The effects of Curcuma longa and curcumin on reproductive systems.

Science.gov (United States)

Mohebbati, R; Anaeigoudari, A; Khazdair, M R

2017-10-26

Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-inflammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an effort on a detailed literature survey concentrated on the protective effects of C. longa and curcumin on the reproductive organs activity. The databases such as, PubMed, Web of Science, Google Scholar, Scopus, and Iran- Medex, were considered. The search terms were "testis" or "ovary" and "Curcuma longa", "curcumin", "antioxidant effect", "anti-inflammatory effect" and "anti-cancer effect". C. longa and curcumin inhibited the production of the tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) and increased the caspases (3, 8 and 9) activities in HL-60 prostate cancer. Furthermore, C. longa and curcumin suppressed the vascular endothelial growth factor (VEGF), phosphorylated signal transducers and activators of the transcription 3 (STAT) and matrix metalloproteinase-9 (MMP-9) in ovarian cancer cell line. C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. C. longa and curcumin have a protective effect on the reproductive organs activity such as, anti-inflammatory, anti-apoptotic, and antioxidant effects in normal cells but showed pro-apoptotic effects in the malignant cells. Therefore, different effects of C. longa and curcumin are dependent on the doses and the type of cells used in various models studied.

Therapeutic uses ofCurcuma longa (turmeric)

OpenAIRE

Luthra, Pratibha Mehta; Singh, Rambir; Chandra, Ramesh

2001-01-01

Curcuma longa commonly known as tumeric is traditionally used as a spice in Indian food. A wide range of biological activities e.g. anticancer, antimicrobial, antiinflammatory and free radical scavenging activity of the plant suggests a logical basis for its traditional use in foodstuff. Various phytothreapeutic uses ofCurcuma longa have been reviewed.

Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation.

Science.gov (United States)

Lee, Kwang-Hee; Kim, Beom-Su; Keum, Ki-Suk; Yu, Hyeon-Hee; Kim, Young-Hoi; Chang, Byoung-Soo; Ra, Ji-Young; Moon, Hae-Dalma; Seo, Bo-Ra; Choi, Na-Young; You, Yong-Ouk

2011-01-01

Curcuma longa (C. longa) has been used as a spice in foods and as an antimicrobial in Oriental medicine. In this study, we evaluated the inhibitory effects of an essential oil isolated from C. longa on the cariogenic properties of Streptococcus mutans (S. mutans), which is an important bacterium in dental plaque and dental caries formation. First, the inhibitory effects of C. longa essential oil on the growth and acid production of S. mutans were tested. Next, the effect of C. longa essential oil on adhesion to saliva-coated hydroxyapatite beads (S-HAs) was investigated. C. longa essential oil inhibited the growth and acid production of S. mutans at concentrations from 0.5 to 4 mg/mL. The essential oil also exhibited significant inhibition of S. mutans adherence to S-HAs at concentrations higher than 0.5 mg/mL. S. mutans biofilm formation was determined by scanning electron microscopy (SEM) and safranin staining. The essential oil of C. longa inhibited the formation of S. mutans biofilms at concentrations higher than 0.5 mg/mL. The components of C. longa essential oil were then analyzed by GC and GC-MS, and the major components were α-turmerone (35.59%), germacrone (19.02%), α-zingiberene (8.74%), αr-turmerone (6.31%), trans-β-elemenone (5.65%), curlone (5.45%), and β-sesquiphellandrene (4.73%). These results suggest that C. longa may inhibit the cariogenic properties of S. mutans. © 2011 Institute of Food Technologists®

Radiaciones electromagnéticas

OpenAIRE

Borrero, Luis M.

2010-01-01

I-La luz; II-El infrarrojo; III-El ultravioleta; IV-Los rayos X. Los rayos gamma. Los rayos intermediarios o de Holweck. Las ondas cortas y las corrientes de alta frecuencia. ResumenIlustraciones: Los rayos cósmicos

Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric).

Science.gov (United States)

Kim, Keunyoung; Kim, Jung-Jun; Jung, Yeryeon; Noh, Ji-Yoon; Syed, Ahmed Shah; Kim, Chul Young; Lee, Moo-Yeol; Lim, Kyung-Min; Bae, Ok-Nam; Chung, Jin-Ho

2017-01-27

Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC 50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product.

La radiación ultravioleta y la piel del deportista

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José Moncada Jiménez

2003-01-01

Full Text Available En este artículo se presenta una revisión de literatura acerca de la relación entre la radiación solar y las lesiones de la piel. Se sabe que una parte de la población se expone diariamente, y a veces durante muchas horas, a la radiación ultravioleta de los rayos solares. Sin embargo, por desconocimiento o por negligencia, muchas personas sufren de lesiones por la exposición aguda o crónica a los rayos solares. En Costa Rica, las lesiones relacionadas con la exposición al sol son comunes; solamente durante el trienio de 1994 a 1996, el cáncer de piel fue el de mayor incidencia entre las mujeres y el segundo entre los hombres. Se ha llegado a determinar que el riesgo para adquirir cáncer de piel aumenta si se poseen ciertas características fenotípicas, como por ejemplo, piel blanca, cabello color rubio o rojo, y ojos color verde o azul. Aún queda por determinar la posible asociación entre la exposición a los rayos ultravioleta en personas que se exponen diariamente durante largos períodos de tiempo a los rayos solares, como por ejemplo los educadores físicos y los deportistas

Physicochemical/photophysical characterization and angiogenic properties of Curcuma longa essential oil.

Science.gov (United States)

Araújo, Lilhian A; Araújo, Rafael G M; Gomes, Flávia O; Lemes, Susy R; Almeida, Luciane M; Maia, Lauro J Q; Gonçalves, Pablo J; Mrué, Fátima; Silva-Junior, Nelson J; Melo-Reis, Paulo R DE

2016-01-01

This study analyzed the physicochemical and photophysical properties of essential oil of Curcuma longa and its angiogenic potential. The results showed that curcumin is the main fluorescent component present in the oil, although the amount is relatively small. The experimental chorioallantoic membrane model was used to evaluate angiogenic activity, showing a significant increase in the vascular network of Curcuma longa and positive control groups when compared to the neutral and inhibitor controls (P Curcuma longa essential oil and the positive control (P >0.05). Histological analysis showed extensive neovascularization, hyperemia and inflammation in the positive control group and Curcuma longa when compared to other controls (P Curcuma longa oil showed considerable proangiogenic activity and could be a potential compound in medical applications.

Estudo de propriedades estruturais e opticas de multicamadas epitaxiais emissoras de luz baseadas em InGaN/GaN

Science.gov (United States)

Pereira, Sergio Manuel de Sousa

Esta tese apresenta os resultados de uma investigacao experimental em filmes epitaxiais emissores de luz baseados em InxGa1-xN. O InxGa1-xN e uma liga semicondutora ternaria do grupo III-N muito utilizada como camada activa numa gama de dispositivos optoelectronicos em desenvolvimento, incluindo diodos emissores de luz (LEDs) e diodos laser (LDs), para operacao na regiao do visivel e ultravioleta do espectro electromagnetico. Neste estudo, caracterizam-se as propriedade opticas e estruturais de camadas simples e pocos quânticos multiplos (Multiple Quantum Wells, MQWs) de InxGa1-xN/GaN, com enfase nas suas propriedades fisicas fundamentais. O objectivo central do trabalho prende-se com a compreensao mais profunda dos processos fisicos que estao por tras das suas propriedades opticas, preenchendo o fosso existente entre aplicacoes tecnologicas e o conhecimento cientifico. Nomeadamente, a tese aborda os problemas da medicao da fraccao de InN (x) em multicamadas ultrafinas sujeitas a tensoes, a influencia da composicao e das tensoes microscopicas nas propriedades opticas e estruturais. A questao relativa a segregacao de fases em multicamadas de InxGa1-xN/GaN e tambem discutida a luz dos resultados obtidos. A metodologia seguida assenta na integracao de resultados obtidos por tecnicas complementares atraves de uma analise sistematica e multidisciplinar. Esta abordagem passa pela combinacao de: 1) Crescimento de amostras por deposicao epitaxial em fase de vapor organometalico (MOVPE) com caracteristicas especificas de forma a tentar isolar parâmetros estruturais, tais como espessura e composicao; 2) Caracterizacao nanoestrutural por microscopia de forca atomica (AFM), microscopica electronica de varrimento (SEM), difraccao de raios-X e retro-dispersao de Rutherford (RBS); 3) Caracterizacao optica a escalas complementares por: espectroscopia de absorcao optica (OA), fotoluminescencia (PL), catodoluminescencia (CL) e microscopia confocal (CM) com analise espectral. Com

Effects of Zingiber officinale, Curcuma longa and Alpinia galanga ...

African Journals Online (AJOL)

Effects of Zingiber officinale, Curcuma longa and Alpinia galanga essential oils on the morphological characteristic of cocoa pod borer, Conopomorpha cramerella. ... Therefore, plant natural product is an alternative for controlling C. cramerella, by using three Zingiberaceae species Zingiberofficinale, Curcuma longa and ...

Light quality management in fruit orchards: physiological and technological aspects Manejo de la calidad de la luz en huertos frutales: Aspectos fisiológicos y tecnológicos

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Richard M. Bastías

2012-12-01

embargo, existe poca información acerca de aspectos fisiológicos y tecnológicos sobre el manejo de la calidad de la luz en cultivos frutales. La composición de luz solar cambia ampliamente en la canopia de los huertos, induciendo diferentes respuestas en la planta mediadas por la actividad del fitocromo (PHY y criptocromo (CRY. Una alta proporción de luz roja-lejana (FR en relación a la roja (R, incrementa la elongación de brotes, mientras que la luz azul (B induce un acortamiento de brotes. La luz R y ultravioleta (UV incrementan la síntesis de antocianinas en la piel de los frutos, mientras que la luz FR muestra un efecto negativo. La luz R y B también pueden alterar caracteres morfo-fisiológicos de la hoja en árboles frutales, tales como grosor de la palizada, apertura estomática y contenido de clorofila. Además de mejorar la disponibilidad de la luz fotosintéticamente activa (PAR, el uso de film reflectantes mejora la proporción de luz UV y R, con efectos positivos sobre respuestas mediadas por el PHY (color de fruto, peso de fruto y crecimiento de brotes, como se reportó en manzano (Malus domestica Borkh., duraznero (Prunus persica L. Batsch y cerezo (Prunus avium (L. L.. Las mallas de color alteran ampliamente la composición espectral de la luz con efectos sobre el crecimiento de planta, rendimiento y calidad en huertos de manzano, duraznero, kiwi (Actinidia deliciosa A. Chev. C.F. Liang & A.R. Ferguson y arándano (Vaccinium corymbosum L.. Los mecanismos de las mallas de color parecen estar asociados a procesos fotosintéticos y morfogenéticos regulados por la disponibilidad de PAR, la proporción de luz B/R, y actividad del CRY. La alteración de la calidad de la luz afecta significantemente respuestas de la planta en árboles frutales y podría ser una herramienta útil para el manejo sostenible (ej. bajo uso de químicos y prácticas laboriosas del rendimiento y calidad en huertos modernos.

De la luz de Roma al oro de Florencia. Luz y legitimación histórica en los humanistas italianos

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Ginés Torres Salinas

2013-06-01

Full Text Available Durante el Renacimiento, desde sus inicios hasta su consolidación, los humanistas utilizaron la contraposición entre luz y oscuridad para legitimar, frente a la medieval, su nueva visión del mundo. En el presente artículo analizaremos el significado concreto con que se dota a la luz en dicha contraposición, así como las diferentes modulaciones que adquiere, dentro de lo que hemos llamado la Edad de la luz.

Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects.

Science.gov (United States)

Wickenberg, Jennie; Ingemansson, Sandra Lindstedt; Hlebowicz, Joanna

2010-10-12

Previous animal studies have shown that Curcuma (C.) longa lowers plasma glucose. C. longa may thus be a promising ingredient in functional foods aimed at preventing type 2 diabetes. The purpose of the study is to study the effect of C. longa on postprandial plasma glucose, insulin levels and glycemic index (GI) in healthy subjects. Fourteen healthy subjects were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with capsules containing a placebo or C. longa. Finger-prick capillary and venous blood samples were collected before, and 15, 30, 45, 60, 90, and 120 min after the start of the OGTT to measure the glucose and insulin levels, respectively. The ingestion of 6 g C. longa had no significant effect on the glucose response. The change in insulin was significantly higher 30 min (P = 0.03) and 60 min (P = 0.041) after the OGTT including C. longa. The insulin AUCs were also significantly higher after the ingestion of C. longa, 15 (P = 0.048), 30 (P = 0.035), 90 (P = 0.03), and 120 (P = 0.02) minutes after the OGTT. The ingestion of 6 g C. longa increased postprandial serum insulin levels, but did not seem to affect plasma glucose levels or GI, in healthy subjects. The results indicate that C. longa may have an effect on insulin secretion.

Physicochemical/photophysical characterization and angiogenic properties of Curcuma longa essential oil

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LILHIAN A. ARAÚJO

Full Text Available ABSTRACT This study analyzed the physicochemical and photophysical properties of essential oil of Curcuma longa and its angiogenic potential. The results showed that curcumin is the main fluorescent component present in the oil, although the amount is relatively small. The experimental chorioallantoic membrane model was used to evaluate angiogenic activity, showing a significant increase in the vascular network of Curcuma longa and positive control groups when compared to the neutral and inhibitor controls (P 0.05. Histological analysis showed extensive neovascularization, hyperemia and inflammation in the positive control group and Curcuma longa when compared to other controls (P <0.05, characteristic factors of the angiogenesis process. In conclusion, Curcuma longa oil showed considerable proangiogenic activity and could be a potential compound in medical applications.

Dosis de radiación ultravioleta en escolares mexicanos

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Castanedo-Cázares Juan Pablo

2003-01-01

Full Text Available OBJETIVO: Determinar la dosis de radiación ultravioleta que reciben los niños y adolescentes durante su asistencia a la escuela primaria, secundaria o preparatoria en la ciudad de San Luis Potosí. MATERIAL Y MÉTODOS: Estudio de cohorte hecho en la ciudad de San Luis Potosí entre mayo de 2001 y abril de 2002. Se evaluaron 80 escolares escogidos al azar de 6 a 19 años de edad, de uno u otro sexo. La dosis se cuantificó durante todo un ciclo escolar mediante el registro del tiempo de exposición solar para cada uno de los alumnos, de modo simultáneo al monitoreo de radiación ultravioleta, para lo cual se utilizaron equipos de radiometría terrestre. Se excluyeron las vacaciones y los fines de semana. Los datos se analizaron en forma univariada y comparativamente, por sexo y meses de exposición; además, se buscó un modelo de regresión para explicar la dosis de exposición solar. RESULTADOS: La dosis promedio ajustada al espectro de eritematógeno acción fue de 16 456 J/m²/año.Hubo diferencias por género: 14 264 J/m²/año/mujeres vs. 18 648 J/m²/año/hombres (Kolmogorov-Smirnof, p=0.003. No hubo diferencias significativas entre grupos, pero sí entre los meses de exposición (Kruskall-Wallis, p=<0.0001. Utilizando la técnica estadística de modelos lineales generalizados, y mediante técnica escalonada y calificación del índice de Akaike se escogió el mejor modelo que explica la dosis de radiación según el mes de exposición, mediante la fórmula 587.20+438.45 (género+500.16(mes-49.65(mes². El resultado muestra mayores dosis de radiación de marzo a septiembre. CONCLUSIONES: Proponemos un marco teórico para la creación de políticas dirigidas a proteger a los alumnos de la sobrexposición solar durante su asistencia a la escuela en México. Se justifica la implantación de medidas preventivas durante al menos el periodo de mayor exposición (marzo a junio, ya que en este lapso se recibe 51% de la dosis anual de radiaci

Nuevas tecnologías aplicadas a la fototerapia y fotodiagnóstico

OpenAIRE

Aguilera-Arjona, Jose

2016-01-01

Desde el descubrimiento de la luz artificial numerosas aplicaciones se han realizado desde el campo de la iluminación artificial para la mejora de la vision en interiores o la visión durante la noche. De forma similar, otras aplicaciones de la luz en el campo de la medicina han desarrollado una larga carrera desde finales del siglo XIX, cuando Niels Finsen inventó el primer sistema de iluminación ultravioleta para la cura de diferentes enfermedades cutaneas. Desde entonces, se han desarrolla...

Estudio genético de la catarata presenil

OpenAIRE

López Valverde, Gloria

2016-01-01

[ES]La catarata es la principal causa de ceguera tratable a nivel mundial. Consiste en una pérdida progresiva de la transparencia del cristalino, por lo general asociada al proceso fisiológico del envejecimiento. Sin embargo, un porcentaje de pacientes presenta cataratas en edades tempranas. La luz solar se ha relacionado como causa de su formación. Existe un grupo de genes que se encarga de la reparación del ADN ante las agresiones externas por agentes como la luz ultravioleta. Hemos est...

Antimicrobial susceptibility of photodynamic therapy (UVA/riboflavin against Staphylococcus aureus Suscetibilidade antimicrobiana da terapia fotodinâmica (UVA/riboflavina contra Staphylococcus aureus

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Renata Tiemi Kashiwabuchi

2012-12-01

Full Text Available PURPOSE: To assess S. aureus in vitro viability after the exposure to ultraviolet light A (UVA and riboflavin (B2. METHODS: Samples of S. aureus in 96 well plates (in triplicate were exposed to riboflavin (B2 and ultraviolet light A (365 nm wavelength at a power density of 3 mW/cm², 8 mm spot diameter, for 30 minutes. Control groups were prepared as well in triplicate: blank control, ultraviolet light A only, riboflavin only and dead bacteria Control. The bacterial viability was measured using fluorescent microscopy. In order to investigate the occurrence of "viable but non-culturable" microorganisms after treatment, the cell viability was also investigated by plate culture procedure onto a broth medium. Statistical analysis was performed using the triplicate values from each experimental condition. RESULTS: No difference was observed among the treatment group and the control samples (p=1. CONCLUSION: The combination of riboflavin 0.1% and ultraviolet light A at 365 nm did not exhibit antimicrobial activity against oxacillin susceptible S. aureus.OBJETIVO: Avaliar a viabilidade celular de S. aureus in vitro após a exposição de riboflavina (B2 e luz ultravioleta A (UVA. MÉTODOS: Amostras de S. aureus colocadas em uma placa de 96 poços (em triplicata foram expostas a riboflavina 0,1% (B2 e luz ultravioleta (comprimento de onda de 365 nm poder de 3 mW/cm², 8 mm de diâmetro, por 30 minutos. Grupos controles foram também preparados em triplicata: controle branco, somente luz ultravioleta A, somente riboflavina e controle morto. A viabilidade bacteriana foi analisada usando microscópio de fluorescência. Para investigar a ocorrência de micro-organismos "viáveis porem não cultiváveis" a viabilidade celular foi avaliada utilizando-se placas de meio de cultivo bacteriano. Analise estatística foi realizada utilizando-se os valores obtidos em triplicata de cada grupo experimental. RESULTADOS: Nenhuma diferença foi observada entre o grupo

Effects of Curcuma longa (turmeric on postprandial plasma glucose and insulin in healthy subjects

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Ingemansson Sandra

2010-10-01

Full Text Available Abstract Background Previous animal studies have shown that Curcuma (C. longa lowers plasma glucose. C. longa may thus be a promising ingredient in functional foods aimed at preventing type 2 diabetes. The purpose of the study is to study the effect of C. longa on postprandial plasma glucose, insulin levels and glycemic index (GI in healthy subjects. Methods Fourteen healthy subjects were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT was administered together with capsules containing a placebo or C. longa. Finger-prick capillary and venous blood samples were collected before, and 15, 30, 45, 60, 90, and 120 min after the start of the OGTT to measure the glucose and insulin levels, respectively. Results The ingestion of 6 g C. longa had no significant effect on the glucose response. The change in insulin was significantly higher 30 min (P = 0.03 and 60 min (P = 0.041 after the OGTT including C. longa. The insulin AUCs were also significantly higher after the ingestion of C. longa, 15 (P = 0.048, 30 (P = 0.035, 90 (P = 0.03, and 120 (P = 0.02 minutes after the OGTT. Conclusions The ingestion of 6 g C. longa increased postprandial serum insulin levels, but did not seem to affect plasma glucose levels or GI, in healthy subjects. The results indicate that C. longa may have an effect on insulin secretion. Trial registration number NCT01029327

Dose-dependent effect of Curcuma longa for the treatment of Parkinson's disease.

Science.gov (United States)

Ma, Xiao-Wei; Guo, Rui-You

2017-05-01

Curcuma longa is a plant that belongs to the ginger family, Zingiberaceae. It has been used in Siddha medicine for thousands of years in Asia. Parkinson's disease (PD) is a degenerative disorder of the central nervous system that affects the motor system of the brain. Death of dopamine-producing cells in the substantia nigra leads to PD. Exposure to salsolinol, which is an endogenous neurotoxin, has been associated with damage to dopamine-producing cells. The present study assessed the toxicity of salsolinol in SH-SY5Y human neuroblastoma cells and subsequently investigated the neuroprotective potential of C. longa extract in salsolinol-induced toxic conditions in SH-SY5Y cells. Sulphorhodamine-B assay showed the protective effect of the anti-apoptotic effect of treated SH-SY5Y cells. Fluorescence microscopy and confocal laser scanning microscope analysis indicated the anti-apoptotic impact of the C. longa extract. Mitochondria-derived reactive oxygen species were reduced in C. longa extract-treated SH-SY5Y cells. Downregulated mRNA expression levels of p53, Bcl-2-associated X protein and caspase 3 were observed in the C. longa extract-treated SH-SY5Y cells. Caspase 3 activity was reduced in the C. longa extract-treated SH-SY5Y cells. In conclusion, the present findings demonstrated that solsolinol is neurotoxic to SH-SY5Y cells, and C. longa extract may be useful in the treatment of PD.

The Effects of Curcuma Longa on the Functionality of Pigmentation for Thin Film Coating

Science.gov (United States)

Marsi, N.; Rus, A. Z. M.; Tan, N. A. M. S.

2017-08-01

This project presents the effects of turmeric (Curcuma Longa) on the functionality of pigmentation was carried out to improve the sustainability, environment impact and reduction of potential cost saving without sacrificing the performance of thin film coating. The Curcuma Longa pigment was extracted by grating the turmeric into small particles at different percentages which is 20%, 40%, 60% and 80% of Curcuma Longa pigment with 3, 6 and 9 layers of coating. The different percentages of Curcuma Longa pigment was formulated and synthesized with polyols by crosslinking agent of glycerol and calcium carbonate into temperature at 140 °C for 2 hours. The results of water droplet test (ASTM D5964) showed the water contact angle was achieved the optimum superhydrophobic characteristic up to 60% of Curcuma Longa at 153°. The formulation of 60% Curcuma Longa was revealed the optimum adhesion resistance test with no flaking and detachment when the coating applied at 9 layers in the classification grading of adhesion test at 5B. It is indicated that the adhesion resistance of thin film coating on metal substrate was obviously increased as the layer of coating as well as the Curcuma Longa pigment percentage up to 60% at 9 layers. This project also highlighted the potential of Curcuma Longa pigment to produce quality in the natural pigmentation as a replacement synthetic pigment which is long-term health hazards.

Solarização do solo com filmes plásticos com e sem aditivo estabilizador de luz ultravioleta Soil solarization with plastic films with and without UV light stabilizers

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Benedito C. Barros

2004-06-01

Full Text Available Visando auxiliar na escolha de filmes plásticos adequados para a solarização, dois experimentos foram instalados em Mogi das Cruzes e Piracicaba (SP, em janeiro e fevereiro de 2000. Três tipos de filmes plásticos transparentes de polietileno de baixa densidade (PEBD, com 100 mm de espessura, produzidos pela empresa Nortène Plásticos Ltda., foram testados: a FES, filme estufa super tricarpa super aditivado, com aditivo estabilizador de luz ultravioleta (baseado em aminas estericamente impedidas; b FSOL, filme para solarização produzido com metade da quantidade do mesmo aditivo e c LT, lona plástica transparente, sem aditivo, além de uma testemunha sem cobertura plástica, em delineamento de blocos casualizados, com quatro repetições. Após a retirada dos plásticos foi conduzida uma safra de alface em ambos os locais. Foi realizada análise química dos solos e das plantas colhidas, além de avaliada a infestação por plantas daninhas e a massa fresca das plantas colhidas. Em Piracicaba também foram realizadas análises microbiológicas dos solos e determinada a viabilidade de Pythium aphanidermattum. Em Mogi das Cruzes foi avaliada a incidência de podridão de esclerotínia, causada por Sclerotinia minor. As temperaturas médias registradas, a 10 cm de profundidade, nos solos sob os diferentes filmes plásticos foram semelhantes, de 44-41ºC nos solos solarizados e de 33,9-30,2ºC nos solos não solarizados de Piracicaba e Mogi das Cruzes, respectivamente. Detectou-se aumento na massa fresca das plantas colhidas nas parcelas solarizadas, de 49% em Piracicaba e 24% em Mogi das Cruzes, independente do plástico testado. Nos dois locais também houve drástica redução na infestação por plantas daninhas nas áreas solarizadas. Nas análises microbianas não foram verificadas alterações na liberação de CO2, no carbono da biomassa microbiana, no quociente metabólico e no número total de bactérias. O número de fungos foi

Estudo da fotodegradação de poliisoprenos naturais (borrachas naturais em radiações específicas do ultravioleta (UV - doi: 10.5102/ucs.v3i2.564

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Kárin Astrid Marques dos Santos

2008-04-01

Full Text Available Filmes de poliisoprenos (PI naturais e sintéticos foram expostos à luz ultravioleta (UV e analisados por espectroscopia de absorção UV, antes e após exposição à radiação UV. Filmes de padrões cis PII foram irradiados separadamente por fontes de luz com comprimentos de ondas iguais a 253 e 300. A fotooxidação foi monitorada observando-se a dependência das intensidades das absorções correspondentes aos modos de estiramento C=C, C=O e O-H e do modo “wagging” =C-H de cis-e trans-PI em função do tempo de exposição. A irradiação em 253 nm levou a reações de reticulação do polímero, impedindo a completa oxidação do filme polimérico. Para irradiação em 300nm, as reações de cisão da cadeia ocorreram preferencialmente, levando à completa oxidação do filme polimérico. Os elastômeros de Hevea brasilienses (HB e Hancornia speciosa (HS foram caracterizadas por espectroscopia de absorção no infravermelho (FTIR como cis-1,4-poliisopreno. A foto-oxidação dos elastômeros apresentou cinética diferente com tempo de indução menor que o observado para os padrões cis-PI. A maior velocidade para o processo de fotodegradação dos filmes de BNs foi atribuída à presença de impurezas, caracterizadas por bandas de absorção nas regiões de estiramento O-H e C=O, mesmo antes da exposição à radiação UV.

Precisiones sobre la luz en el Pantheon de Roma

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Oscar Linares de la Torre

2015-04-01

Full Text Available El Pantheon de Adriano es una de las obras más celebradas de la historia de la arquitectura. Han sido muchas las cuestiones que han cautivado a cuantos han entrado en él, pero es la luz la que ha acaparado el mayor protagonismo: una vez despojado el edificio de su originaria carga simbólica, la manifestación de su luz interior parece ser el único fin de este inmenso espacio-luz que tanto ha fascinado a arquitectos, historiadores del arte, pintores y fotógrafos. Parece difícil poder aportar nada nuevo. Consciente de ello, el autor del presente artículo sólo pretende apuntar algunas cuestiones sobre distintos aspectos de la luz en el Pantheon que considera que no han sido aún suficientemente desarrolladas: el por qué de la orientación solar y urbana del templo con respecto al eje norte-sur; la reconstrucción de la secuencia de luz y sombra que debió de darse en el recorrido original de acceso al interior del templo; la interpretación del haz de luz ocular como reminiscencia inmaterial del soporte central de las falsas cúpulas etruscas, convertida en una columna de materia sutil que, sin alcanzar nunca la vertical, incide de manera variada sobre los paramentos que conforman el interior.

Effects of alcoholic extract of Curcuma longa on Ascaridia infestation affecting chicken.

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Alrubaie, Abdulrazak Labi

2015-07-01

Ascaridia galli, the common intestinal nematode, remains a major cause of economic loss in the poultry industry in developing countries. Treatments using chemicals are not only expensive but also affect host health. Plant extracts as better alternative is gaining significance. Here, we have studied the effects of alcoholic extract of turmeric, Curcuma longa L. (Zingiberaceae) roots, against A. galli infection in chicken. Different concentrations of C. longa root extract were tested in vitro on 5 groups of adults A. galli worms and in vivo on 6 groups of chicks. The results showed that the turmeric root extract @ 60 mg mL(-1) in vitro significantly (P longa had healing effects and restored the integrity of intestinal mucosa. The results have demonstrated the ameliorating effect of C. longa turmeric on A. galli infested chickens.

Dietary Curcuma longa enhances resistance against Eimeria maxima and Eimeria tenella infections in chickens.

Science.gov (United States)

Kim, Duk Kyung; Lillehoj, Hyun S; Lee, Sung Hyen; Jang, Seung I; Lillehoj, Erik P; Bravo, David

2013-10-01

The effects of dietary supplementation with an organic extract of Curcuma longa on systemic and local immune responses to experimental Eimeria maxima and Eimeria tenella infections were evaluated in commercial broiler chickens. Dietary supplementation with C. longa enhanced coccidiosis resistance as demonstrated by increased BW gains, reduced fecal oocyst shedding, and decreased gut lesions compared with infected birds fed a nonsupplemented control diet. The chickens fed C. longa-supplemented diet showed enhanced systemic humoral immunity, as assessed by greater levels of serum antibodies to an Eimeria microneme protein, MIC2, and enhanced cellular immunity, as measured by concanavalin A-induced spleen cell proliferation, compared with controls. At the intestinal level, genome-wide gene expression profiling by microarray hybridization identified 601 differentially expressed transcripts (287 upregulated, 314 downregulated) in gut lymphocytes of C. longa-fed chickens compared with nonsupplemented controls. Based on the known functions of the corresponding mammalian genes, the C. longa-induced intestinal transcriptome was mostly associated with genes mediating anti-inflammatory effects. Taken together, these results suggest that dietary C. longa could be used to attenuate Eimeria-induced, inflammation-mediated gut damage in commercial poultry production.

Reflections about Osteoarthritis and Curcuma longa

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Akuri, Marina Cristina; Barbalho, Sandra Maria; Val, Raíssa Meira; Guiguer, Elen Landgraf

2017-01-01

Osteoarthritis (OA) is a chronic inflammatory degenerative process that affects joints such as the hands, hips, shoulders, feet, spine, and especially knees in millions of people worldwide. Some authors have shown that Curcuma longa components may exhibit benefic effects in the treatment of degenerative diseases as OA. This plant belongs to the family Zingiberaceae and it is popularly known as turmeric or saffron. This review intended to perform a retrospective search to identify studies involving humans and animal models. This review was based on articles linking OA and C. longa. Databases as Medline, Science Direct, and Lilacs were consulted and a retrospective search was carried out in order to identify studies involving humans and animal models. The curcuminoids from C. longa exhibit actions at different locations in the pathogenesis of OA once it may play an important role as anti-inflammatory, down-regulating enzymes as phospholipase A2, cyclooxygenase-2, and lipoxygenases, and reducing tumor necrosis factor-alpha-and interleukins such as interleukin-1β (IL-1β), IL-6, and IL-8. They also act as inducer of apoptosis in synoviocytes, decreasing the inflammation process and may also reduce the synthesis of reactive oxygen species. For these reasons, new pharmaceutical technology and pharmacological studies should be proposed to determine the dose, the best delivery vehicle, pharmaceutical formulation and route of administration of this plant so its use as an adjunct in the treatment of OA may become a reality in clinical practice. PMID:28503046

In vitro antioxidant activity of n-butanol extract of Curcuma longa and ...

African Journals Online (AJOL)

Antioxidant activity of Curcuma longa rhizomes (Turmeric) has been widely investigated in Asia. This work evaluated the antioxidant potential of Nigerian variety of Curcuma longa with the main hypothesis that variation in plant phytochemicals in type and/or amount is a function of geographical location/soil type.

Estratégias para luz natural: sistemas inovadores.

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Juliana Saiter Garrocho

2007-07-01

Full Text Available Diversos sistemas, estratégias e componentesinovadores de alta tecnologia paraa otimização do uso da luz natural noprojeto de arquitetura têm se desenvolvidoatualmente, principalmente na EuropaCentral, nos Estados Unidos e na Austrália.Este artigo apresenta algumas dessasestratégias descrevendo suas principaiscaracterísticas. Palavras-chave: luz natural, estratégias deprojeto, sistemas inovadores de alta tecnologia.

Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin.

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Kaur, Chanchal Deep; Saraf, Swarnlata

2011-12-01

  Ultraviolet radiations generate reactive oxygen species, leading to adverse effects on skin properties. Botanical extracts are multifunctional in nature having various properties like photoprotection, anti-aging, moisturizing, antioxidant, astringent, anti-irritant, and antimicrobial activity.   The aim of this study was to formulate creams having Curcuma longa extract loaded novel vesicular systems (liposomes, ethosomes, and transfersomes) and study their photoprotective effect by assessment of skin hydration (Cutometer) and sebum content (Sebumeter).   The alcoholic C. longa extract loaded liposomes, ethosomes, and transfersomes having 0.5-2.0% w/w extract were prepared, evaluated for size, entrapment efficiency, and incorporated into the cream. Their long-term interaction with skin (6 weeks) was compared in terms of their effects on skin hydration and sebum content.   Vesicular size obtained was in the range 167.3 ± 3.0 to 262.4 ± 2.4 nm with low polydispersity index (0.2-0.3) and high entrapment efficiency. The efficacy was in the order C. longa extract loaded transfersomal creams > C. longa extract loaded ethosomal creams > C. longa extract loaded liposomal creams > C. longa extract loaded creams > Empty transfersome loaded cream > Empty ethosome loaded cream > Empty liposome loaded cream > Base cream.   The photoprotective properties of the constituents of C. longa extract and hydrant, moisturizing lipid components of nano vesicles with better skin penetration resulted in improvement in skin properties like skin hydration and sebum content. The herbal extract loaded nano vesicles incorporated in cream could be used as photoprotective formulations. © 2011 Wiley Periodicals, Inc.

Cromatografía de capa fina

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Blay Llinares, Gonzalo

2011-01-01

Este video explica como preparar y llevar a cabo un análisis mediante cromatografía de capa fina. Se enseña cómo cortar el cromatofolio, preparar las disoluciones de las muestras, depositarlas en el cromatofolio , la elución de las muestras y el revelado del cromatograma a la luz ultravioleta y con un revelador químico.

Absolute Configurations and NO Inhibitory Activities of Terpenoids from Curcuma longa.

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Xu, Jing; Ji, Feifei; Kang, Jing; Wang, Hao; Li, Shen; Jin, Da-Qing; Zhang, Qiang; Sun, Hongwei; Guo, Yuanqiang

2015-06-24

Curcuma longa L., belonging to the Zingiberaceae family, is a perennial herb and has been used as a spice and a pigment in the food industry. In the ongoing search for inhibitory reagents of NO production and survey of the chemical composition of natural vegetable foods, the chemical constituents of C. longa used as spice were investigated. This investigation resulted in the isolation of 2 new terpenoids and 14 known analogues. Their structures were established on the basis of the extensive analyses of 1D and 2D NMR spectroscopic data, and the absolute configurations of 1-4 were elucidated by comparison of the calculated and experimental ECD spectra. Among them, compound 1 is a rare norditerpene with an ent-labdane skeleton, and 2 is a skeletally novel sesquiterpene having an eight-membered ring. All of the compounds were found to possess NO inhibitory activities in murine microglial BV-2 cells. The discovery of two new compounds in this chemical investigation further disclosed the chemical composition of C. longa used a food spice, and the bioassay implied that the natural food spice C. longa, containing terpenoids with NO inhibitory activities, may be potentially promotive to human health.

The life cycle of Ascocotyle (Phagicola) longa (Digenea: Heterophyidae), a causative agent of fish-borne trematodosis.

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Simões, Susana Balmant Emerique; Barbosa, Helene Santos; Santos, Cláudia Portes

2010-03-01

The complete life cycle of the trematode Ascocotyle (Phagicola) longa (Digenea: Heterophyidae) is elucidated by natural observation validated by experimental infections. The natural first intermediate host of A. (P.) longa, an agent of human heterophyiasis in Brazil, is the cochliopid snail Heleobia australis (new first intermediate host). Metacercariae were found encysted in the body musculature, heart, stomach, liver, kidney, spleen, gonads and mesentery of mullets Mugil liza. Hamsters Mesocricetus auratus were experimentally infected with metacercariae of A. (P.) longa obtained from the mullets, and the adults recovered were used to infect the snails H. australis. Rediae and cercariae of A. (P.) longa are described for the first time. The ultrastructure of the tegument of A. (P.) longa shows a change in spination pattern from the cercaria with single-pointed spines to the metacercaria and adult with multipointed, brush-shaped spines. The life cycle of A. (P.) longa is related to estuaries and coastal lagoons where the recruitment of mugilid juveniles occurs. The high prevalence (100%) of A. (P.) longa encysted in the mullets examined within the urban area of Rio de Janeiro indicates the potentially great public health impact of the consumption of raw mullets. Copyright 2009 Elsevier B.V. All rights reserved.

Efeito do filtro de ultravioleta em lentes de contato hidrofílicas de alta hidratação Ultraviolet filter effect on hydrophilic high hydrated contact lenses

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Arlindo José Freire Portes

2008-06-01

Full Text Available A exposição à radiação ultravioleta está relacionada ao aparecimento de patologias oculares como ceratites, cataratas, degenerações maculares ou pterígio. Esta radiação está dividida em 3 tipos de acordo com o seu comprimento de onda: Uv-A (320-400nm, Uv-B (290-320nm e Uv-C (100-290nm. A indústria óptica desenvolveu filtros de ultravioleta para lentes intra-oculares, lentes de contato e lentes de óculos. OBJETIVO: Avaliar a eficácia do filtro de ultravioleta em lentes de contato de alta hidratação. MÉTODOS: Seis grupos de lentes de contato de alta hidratação e de marcas diferentes, contendo 3 unidades novas e iguais foram estudadas, observando-se o percentual de transmissão da energia luminosa de 200 a 400 nm através de um espectofotômetro. RESULTADOS: Os 3 grupos que apresentavam filtro de ultravioleta causaram uma queda abrupta na transmissão da radiação ultravioleta de 400 nm até 340 nm, ocorrendo um aumento na transmissão entre 240 a 300 nm até um nível máximo de 45%. Abaixo de 240 nm e entre 300 e 340 nm, houve um completo bloqueio da transmissão da radiação ultravioleta. Os 3 grupos que não apresentavam filtros de ultravioleta causaram uma queda abrupta na transmissão da radiação ultravioleta abaixo de 240 nm, ocorrendo um bloqueio completo de transmissão abaixo de 220 nm. CONCLUSÃO: As lentes de contato sem filtro Uv testadas não bloquearam com eficácia a radiação Uv-A, B ou C, e as com filtro bloquearam quase totalmente a radiação Uv-B e parcialmente a radiação Uv-A e Uv-C.The exposure to ultraviolet radiation is associated with the beginning of ocular pathologies like keratites, cataract, age-related macular degeneration and pterygium. This radiation is divided in 3 bands according to the wave length: Uv-A (320-400, Uv-B (290-320, Uv-C (100-290. The optic industry developed ultraviolet filters to intraocular lenses, contact lenses and spectacle lenses. PURPOSE: The issue of this work is

EFFECT OF TURMERIC (CURCUMA LONGA SUPPLEMENTATION ON GROWTH AND BLOOD CHEMISTRY OF BROILERS

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Kamdev Sethy

2016-06-01

Full Text Available To access the effect of turmeric (Curcuma longa supplementation on growth and blood chemistry of broiler chickens, seventy five day old straight run coloured synthetic broiler chicks were randomly divided into 3 groups (25 chicks per group. Group I served as control (without any supplementation, where as birds in groups II and III were supplemented with 0.5% and 1.0% Curcuma longa powder respectively and the trail was lasted for 7 weeks, during which weekly body weight changes were recorded. Blood samples were collected at the end of the experiment to study the blood profile of birds. The results indicated that addition of Curcuma longa powder caused significant (P0.05 effect on blood biochemical parameters of bird. The present results confirmed the beneficial effects of dietary Curcuma longa powder to improve body weight and Hb concentration of broiler chickens.

The Effects Of Irradiation On The Active Compounds In Curcuma Longa

International Nuclear Information System (INIS)

Suntararuks, Sumitra; Charoenying, Siravit; Rangkadilok, Nuchanart; Satayavivad, Jutamaad

2005-10-01

Food irradiation is a technology to control spoilage and eliminate food-borne pathogens such as Escherichia coli, salmonella, yeasts and mold. It is also applied to spices, herbs, and natural products including Fahthalai and Curcuma longa (C. longa) products. Therefore, it is important to study the effect of irradiation on the active compounds in these products (two crude and two extracts). The results indicated that HPLC and TLC fingerprints of C. longa samples were similar for both before and after irradiation (2.5, 5, 10, 25 kGy). There were no any new compounds occurred after irradiation and during storage. The curcumin content in C. longa crude (2 samples) was stable during 12 months of this study. However, the curcumin content in 2 extracts trended to increase during storage time. Irradiation process at least 5 kGy can reduce some bacteria and fungi contaminations in natural products to the acceptable level indicated in the quality control methods for medicinal plant materials (WHO, 1998). The amount of microorganism growth were not more than 105, 104, 103 colony forming unit (CFU) of each sample for aerobic bacteria, fungi, and enterobacteriaceae growth, respectively, and E. coli, Salmonella spp. and Staphylococcus aureus were not found in all samples

Estudos sôbre o complemento: II - Análise eletroforética do complemento inativado pelas radiações ultravioleta

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F. Rocha Lagôa

1953-12-01

Full Text Available Foi realizada a análise eletroforética de sôros de cobaio, contendo complemento inativado pelas radiações ultravioleta, sendo verificada a existência de modificação na quantidade de albumina e um acréscimo correspondente da zona eletroforética das alfa-globulinas o que confirma a observação anterior de que a fraçãoo do complemento sensível as radiações ultravioleta, e o seu segundo componente (C2.The electrophoretic analysis of sera from guinea pigs was made with complement inactivated by ultraviolet radiations. It was found that the quantity of albumin changed, and an increase of the corresponding electrophoretic area of the globulins-alpha also took place, therefore, confirming the observations made previously that the fraction of the complement destroyed by ultraviolet radiations is its second component (albumin fraction, C2.

Dietary Curcuma longa enhances resistance against Eimeria maxima and Eimeria tenella infections in chickens

Science.gov (United States)

The effects of dietary supplementation with an organic extract of Curcuma longa on systemic and local immune responses to experimental Eimeria maxima and E. tenella infections were evaluated in commercial broiler chickens. Infected chickens given the C. longa-containing diet had increased body weig...

Protective effect of crude Curcuma longa and its methanolic extract in alloxanized rabbits.

Science.gov (United States)

Ahmad, Mobasher; Kamran, Sairah Hafeez; Mobasher, Afroze

2014-01-01

Curcuma longa (C. longa) is commonly found in different areas of Pakistan. It has been locally utilized as a traditional medicine. The aim of this study was to evaluate the antidiabetic, hepatoprotective and total antioxidant effect of the crude drug and its methanolic extract in rabbits. Diabetes was induced with alloxan (180mg/kg). Two major groups were designed, curative and protective groups. In curative group the crude drug and its methanolic extract was orally administered to the diabetic animals and acute study was performed. On the other hand in protective group the crude drug and its methanolic extract were administered for eight days prior to the diabetes induction. Results indicated that in Curative group the crude and methanolic extract of C. longa significantly improved the levels of serum glucose, serum transaminases and antioxidant activity (AOA). In protective group, serum glucose, serum transaminases were not significantly increased by alloxan, in both crude as well as methanolic extract group. This study shows that C. longa acts as antidiabetic, hepatoprotective and antioxidant in diabetes especially type 1 diabetes.

Uji Daya Hambat Ekstrak Rimpang Kunyit (Curcuma Longa) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Dan Pseudomonas SP.

OpenAIRE

Pangemanan, Andrew; Fatimawali; Budiarso, Fona

2016-01-01

: Turmeric (Curcuma longa) is a plant that is known to have medicinal properties, especially the rhizome. The active compound that contained in the rhizomes are able to work as an antibacterial. This study aimed to measure the inhibitory of turmeric rhizome (Curcuma longa) extract against the growth of Staphylococcus aureus and Pseudomonas sp. This was an experimental laboratory study. The polar extract of turmeric rhizome (Curcuma longa) was tested by well method with concentration of 40%, 2...

Curcuma longa Is Able to Induce Apoptotic Cell Death of Pterygium-Derived Human Keratinocytes.

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Sancilio, Silvia; Di Staso, Silvio; Sebastiani, Stefano; Centurione, Lucia; Di Girolamo, Nick; Ciancaglini, Marco; Di Pietro, Roberta

2017-01-01

Pterygium is a relatively common eye disease that can display an aggressive clinical behaviour. To evaluate the in vitro effects of Curcuma longa on human pterygium-derived keratinocytes, specimens of pterygium from 20 patients undergoing pterygium surgical excision were collected. Pterygium explants were put into culture and derived keratinocytes were treated with an alcoholic extract of 1.3% Curcuma longa in 0.001% Benzalkonium Chloride for 3, 6, and 24 h. Cultured cells were examined for CAM5.2 (anti-cytokeratin antibody) and CD140 (anti-fibroblast transmembrane glycoprotein antibody) expression between 3th and 16th passage to assess cell homogeneity. TUNEL technique and Annexin-V/PI staining in flow cytometry were used to detect keratinocyte apoptosis. We showed that Curcuma longa exerts a proapoptotic effect on pterygium-derived keratinocytes already after 3 h treatment. Moreover, after 24 h treatment, Curcuma longa induces a significant increase in TUNEL as well as Annexin-V/PI positive cells in comparison to untreated samples. Our study confirms previous observations highlighting the expression, in pterygium keratinocytes, of nuclear VEGF and gives evidence for the first time to the expression of nuclear and cytoplasmic VEGF-R1. All in all, these findings suggest that Curcuma longa could have some therapeutic potential in the treatment and prevention of human pterygium.

Curcuma longa Is Able to Induce Apoptotic Cell Death of Pterygium-Derived Human Keratinocytes

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Silvia Sancilio

2017-01-01

Full Text Available Pterygium is a relatively common eye disease that can display an aggressive clinical behaviour. To evaluate the in vitro effects of Curcuma longa on human pterygium-derived keratinocytes, specimens of pterygium from 20 patients undergoing pterygium surgical excision were collected. Pterygium explants were put into culture and derived keratinocytes were treated with an alcoholic extract of 1.3% Curcuma longa in 0.001% Benzalkonium Chloride for 3, 6, and 24 h. Cultured cells were examined for CAM5.2 (anti-cytokeratin antibody and CD140 (anti-fibroblast transmembrane glycoprotein antibody expression between 3th and 16th passage to assess cell homogeneity. TUNEL technique and Annexin-V/PI staining in flow cytometry were used to detect keratinocyte apoptosis. We showed that Curcuma longa exerts a proapoptotic effect on pterygium-derived keratinocytes already after 3 h treatment. Moreover, after 24 h treatment, Curcuma longa induces a significant increase in TUNEL as well as Annexin-V/PI positive cells in comparison to untreated samples. Our study confirms previous observations highlighting the expression, in pterygium keratinocytes, of nuclear VEGF and gives evidence for the first time to the expression of nuclear and cytoplasmic VEGF-R1. All in all, these findings suggest that Curcuma longa could have some therapeutic potential in the treatment and prevention of human pterygium.

Antiviral effects of Curcuma longa L. against dengue virus in vitro and in vivo

Science.gov (United States)

Ichsyani, M.; Ridhanya, A.; Risanti, M.; Desti, H.; Ceria, R.; Putri, D. H.; Sudiro, T. M.; Dewi, B. E.

2017-12-01

Dengue is the most common infective disease caused by dengue virus (DENV) and endemic diseases in tropical and subtropical areas. Until now, there is no specific antiviral for dengue infection. It is known that viral load is related to disease severity. Curcuma longa L. (turmeric) with curcumin as major active compound has been identified for its antiviral effect. This study to determine antiviral effect of C. longa extract on DENV-2 in vitro and in vivo along with its toxicity in liver and kidney of ddY mice. Antiviral activity (IC50) and toxicity (CC50) in vitro was examined on Huh7it-1 cells by focus assay and a MTT assay, respectively. To determine the selectivity index (SI), we used CC50 and IC50 value. The safe doses obtained were used for toxicity tests of liver and kidney with histopathological and biochemical observations. The C. longa extracts was given orally with dose of 0.147 mg/mL for each mice at 2 hours after injected with DENV-2 infected Huh7it-1 cells. Serum was collected from intraorbital at 6 hours and 24 hours after infection and focus assay was used to determine viral load. In this study, the acquired value of IC50 was 17,91 μg/mL whereas the value of CC50 was 85,4 μg/mL. The value of SI of C. longa was 4.8. In vivo, we found that C. longa remarkable reduced of viral load after 24 hour. Histopathological examination showed no specific abnormalities in liver and kidney. There was no significant increase in levels of SGPT, SGOT, urea, and creatinine. From this study it can be concluded that C. longa could potentially be used as antiviral against DENV with low cytotoxicity and effective inhibition.

Curcuma longa and Curcuma mangga leaves exhibit functional food property.

Science.gov (United States)

Liu, Yunbao; Nair, Muraleedharan G

2012-11-15

Although leaves of Curcuma mangga and Curcuma longa are used in food preparations, the bioactive components in it are not known. In this study, antioxidant, antiinflammatory and anticancer activities of leave extracts and its isolates were investigated using established bioassay procedures in our laboratory. The leaf extracts of both plants gave similar bioassay and chromatographic profiles. The methanolic and water extracts of C. mangga (CMM and CMW) and C. longa (CLM and CLW), at 100 μg/mL, inhibited lipid peroxidation (LPO) by 78%, 63%, 81% and 43%, cyclooxygenase enzymes COX-1 by 55%, 33%, 43% and 24% and COX-2 by 65%, 55%, 77% and 69%, respectively. At same concentration, CMM, CMW, CLM and CLW showed growth inhibition of human tumour cell lines by 0-46%. Therefore, a bioassay-guided isolation of water and methanolic extracts of C. longa was carried out and afforded nine isolates. At 25 μg/mL, these compounds inhibited LPO by 11-87%, COX-1 and -2 enzymes by 0-35% and 0-82% and growth of human tumour cells by 0-36%, respectively. Copyright © 2012 Elsevier Ltd. All rights reserved.

Curcuma longa extract as a histological dye for collagen fibres and red blood cells

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Avwioro, O G; Onwuka, S K; Moody, J O; Agbedahunsi, J M; Oduola, T; Ekpo, O E; Oladele, A A

2007-01-01

Crude ethanolic extract and column chromatographic fractions of the Allepey cultivar of Curcuma longa Roxb, commonly called turmeric (tumeric) in commerce, were used as a stain for tissue sections. Staining was carried out under basic, acidic and neutral media conditions. Inorganic and organic dissolution solvents were used. The stain was used as a counterstain after alum and iron haematoxylins. C. longa stained collagen fibres, cytoplasm, red blood cells and muscle cells yellow. It also stained in a fashion similar to eosin, except for its intense yellow colour. Preliminary phytochemical evaluation of the active column fraction revealed that it contained flavonoids, free anthraquinone and deoxy sugar. A cheap, natural dye can thus be obtained from C. longa. PMID:17451535

Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats.

Science.gov (United States)

Agarwal, Renu; Gupta, S K; Agarwal, Puneet; Srivastava, Sushma

2013-10-01

Aqueous extract of C. longa when administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade and aqueous humor (AH) protein level compared to vehicle treated group. Although, prednisolone group showed significantly lower clinical grade, histopathological grades and AH protein levels compared to C. longa group, TNF-alpha levels did not differ significantly. Moreover, when the aqueous extract was administered starting from 3 days before induction of uveitis, the mean clinical and histopathological grade as well as AH protein and TNF-alpha levels were comparable to C. longa group when treatment was administered 4 h after induction of uveitis. It is concluded that topically applied standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity.

O GPS e a velocidade constante da luz

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Paul Marmet

2000-05-01

Full Text Available As transformações de Lorentz e a relatividade especial são incapazes de fornecer uma explicação física realística do comportamento da matéria e da luz. Mostraremos aqui que todos esses fenômenos podem ser explicados usando-se a física de Newton e a conservação da massa-energia, sem apelar para a contração espacial ou a dilatação do tempo. Sabemos que o princípio de conservação da massa-energia requer que os relógios funcionem mais devagar em um referencial móvel, e que os corpos físicos tornam-se maiores devido ao acréscimo do raio de Bohr. Estes resultados nos permitem levantar a seguinte questão: A luz viaja com respeito a quê? Por exemplo, quando nos distanciamos a uma velocidade v de uma fonte emissora de luz, que, por sua vez, se desloca com velocidade c, o movimento relativo da radiação é dado por um deslocamento Doppler. Como podemos explicar logicamente que estes fótons parecem chegar até nós a uma velocidade c e não a uma velocidade (c – v? A explicação convencional remete à relatividade especial, mas isto implica em uma esotérica distorção espaço-temporal, que não é compatível com a lógica. Este artigo fornece uma explicação física de como a velocidade da luz é realmente (c – v com respeito ao observador, mesmo se as ferramentas do observador sempre meçam a velocidade representada pelo número c. Explicamos como este problema é crucial no Global Positioning System (GPS – Sistema de Posicionamento Global e na sincronização dos relógios. As transformações de Lorentz tornam-se desnecessárias. Esta aparente constância da velocidade da luz com respeito a um referencial móvel é a mais fascinante ilusão na ciência.

Novedoso fotodetector selectivo al ultravioleta basado en dióxido de titanio nanocristalino

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H. Wang

2011-01-01

Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Las potencialidades como sensor selectivo de ultravioleta (UV de una celda fotoelectroquímica sellada basada en TiO2 nanocristalino son estudiadas. La componente ultravioleta del espectro solar origina afectaciones en la piel y otras enfermedades; además de provocar limitaciones al desarrollo de los animales y plantas El incremento de la radiación UV exige el uso de sensores para este rango espectral. El TiO2 nanocristalino es un material barato, inocuo y muy estable; actualmente estudiado intensamente debido a sus aplicaciones en celdas solares sensibilizadas. Se describen la obtención y  estructura de los dispositivos y se estudian dos tipos de fotodetectores con diferentes estructuras de capas. Para ello se analizan parámetros característicos del fotodetector tales como la sensibilidad espectral, la eficiencia cuántica externa, la dependencia de la fotocorriente vs la intensidad luminosa y la curva volt-ampérica en oscuridad e iluminada. Los valores de sensibilidad obtenidos y la dependencia lineal de la fotocorriente con la intensidad incidente, unidos a su bajo costo, confieren buenas perspectivas para el desarrollo de este tipo de sensor.

[Dynamic accumulation regulation of curcumin, demethoxycurcumin and bisdemethoxyeurcumin in three strains of curcuma longae rhizome].

Science.gov (United States)

Li, Qing-Miao; Yang, Wen-Yu; Tang, Xue-Mei; Zhang, Mei; Zhou, Xian-Jian; Shu, Guang-Ming; Zhao, Jun-Ning; Fang, Qing-Mao

2014-06-01

The paper is aimed to study the dynamic accumulation regulation of curcumin (Cur), demethoxycurcumin (DMC) and bisdemethoxyeurcumin (BDMC) in three strains of Curcuma longa, and provide scientific references for formalized cultivation, timely harvesting, quality control and breeding cultivation of C. longa. The accumulation regulation of the three curcumin derivatives was basically the same in rhizome of three strains. The relative contents decreased along with plant development growing, while the accumulation per hectare increased with plant development growing. The accumulation of curcuminoids per hectare could be taken as the assessment standard for the best harvest time of C. longa. A3 was the best strain in terms of Cur and BDMC content.

Desinfecção de água de chuva por radiação ultravioleta Disinfection of rainwater by ultraviolet radiation

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Elisabeth Wisbeck

2011-12-01

Full Text Available O objetivo deste trabalho foi avaliar o tratamento de água de chuva, de duas regiões industriais de Joinville (SC, por radiação ultravioleta. O reator operou em processo contínuo, de modo que cada partícula permanecesse sob radiação por 60 segundos. As amostras de água foram analisadas em termos de coliformes totais, coliformes termotolerantes e bactérias heterotróficas antes do tratamento por ultravioleta, após o tratamento e após tratadas e armazenadas por 24, 48 e 72 horas. Verificou-se a eficiência da desinfecção de água de chuva direta e de telhado por radiação ultravioleta com a inativação de 100% dos coliformes totais e dos coliformes termotolerantes e o não recrescimento desses micro-organismos em amostras tratadas e estocados por até 72 horas, no entanto, bactérias heterotróficas persistiram e foram identificadas após 24, 48 e 72 horas ao tratamento.The objective of this study was to evaluate the treatment of rainwater in two industrial regions in Joinville (SC, Brazil by ultraviolet radiation. The reactor was operating in continuous process with each particle remaining under radiation for 60 seconds. The samples were evaluated in terms of total coliforms, fecal coliform and heterotrophic bacteria prior to ultraviolet treatment, after treatment and further treated and stored for 24, 48 and 72 hours. The efficiency of disinfection of direct rainwater and that collected from roofing by ultraviolet radiation was verified with 100% inactivation of total coliforms and fecal coliform and these microorganisms did not reappear in samples treated and stored for up to 72 hours, however, heterotrophic bacteria persisted and were identified after 24, 48 and 72 hours of treatment.

ISOLASI DAN IDENTIFIKASI KAPANG ENDOFIT DARI TANAMAN KUNYIT (Curcuma longa L. SEBAGAI PENGHASIL ANTIOKSIDAN

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Tiwit Widowati

2016-06-01

Full Text Available Endophyte fungi are microbe that living inside the plant tissue without harming the host plant. Endophyte fungi can produce secondary metabolite which can be used as antioxidant, anticancer and antimicobes compound. Endophyte fungi can be found in many plants especially herbs such as turmeric (Curcuma longa L. The aims of this study are to isolate and identify endophyte fungi from stem of C. longa L. which is potential as an antioxidant producer. The endophyte fungi isolated from turmeric stem were 12 isolates. Antioxidant activity was assayed using 1,1-Diphenyl-2-picryl-hydrazyl (DPPH showed that isolate K.Cl.Sb.B1 produced the highest inhibition value (78,81%. Based on molecular identification, the isolate K.Cl.Sb.B1 was Colletotrichum sp.Keywords: Curcuma longa L., endophyte fungi, identification antioxidant ABSTRAKKapang endofit merupakan mikroba yang terdapat di dalam jaringan tanaman tanpa membahayakan tanaman inang. Kapang endofit mampu menghasilkan metabolit sekunder yang dapat dimanfaatkan sebagai senyawa antioksidan, antikanker dan antimikroba. Kapang endofit dapat ditemukan pada berbagai jenis tanaman terutama tanaman obat seperti kunyit (Curcuma longa L. Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi kapang endofit dari batang tanaman kunyit yang berpotensi sebagai penghasil antioksidan. Kapang endofit yang diisolasi dari batang tanaman kunyit diperoleh 12 isolat. Uji antioksidan menggunakan 1,1-Diphenyl-2-picryl-hydrazyl (DPPH menunjukkan bahwa isolat K.Cl.Sb.B1 menghasilkan nilai inhibisi tertinggi (78,81%. Berdasarkan identifikasi molekuler, isolat K.Cl.Sb.B1 merupakan Colletotrichum sp.Kata kunci: Curcuma longa L., identifikasi antioksidan, kapang endofit

Curcuma longa as additive in the diet for Astyanax aff. bimaculatus.

Science.gov (United States)

de Moraes França Ferreira, Pollyanna; Martins, Maria Tatiana Soares; Caldas, Débora Werneck; Gomes, Juliana Rodrigues; de Oliveira, Jerusa Maria; Salaro, Ana Lucia; Rocha, Juliana Silva; Zuanon, Jener Alexandre Sampaio

2017-06-01

The aim of the present study was to evaluate the effect of turmeric (Curcuma longa) as additive in the diet for Astyanax aff. bimaculatus. Fish (0.83 ± 0.04 g) were fed, for 60 days, with six diets containing 0.0, 20.0, 40.0, 60.0, 80.0, and 100.0 g turmeric kg -1 feed. There was an increasing linear effect of turmeric on the thickness of the muscular layer, and height and width of the folds of the intestine. In the liver, a quadratic effect was observed of turmeric on the percentage of hepatocyte cytoplasm and a decreasing linear effect on the percentage of sinusoid capillaries. A quadratic effect was also observed of turmeric on the liver glycogen. There was no effect of turmeric on the antioxidant activity in the liver, carcass composition or productive performance of the fish. Thus, we concluded that Curcuma longa has trophic effects on the epithelium and the muscular layer of the intestine of A. aff. bimaculatus. Additionally, low levels of Curcuma longa cause increased deposition of liver glycogen and high levels cause reduction.

Effect of Turmeric ( Curcuma longa Zingiberaceae ) Extract Cream ...

African Journals Online (AJOL)

... was 88.5% of the standard. Conclusion: The study demonstrates that the extract obtained from the rhizomes of turmeric plant can be used in skin preparations to regulate excessive sebum secretion in persons suffering from acne and related problems. Keywords: Tumeric, Sebum, Curcuma longa, Sebumeter, Skin, Acne ...

Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice.

Science.gov (United States)

Kadri, Yamina; Nciri, Riadh; Brahmi, Noura; Saidi, Saber; Harrath, Abdel Halim; Alwasel, Saleh; Aldahmash, Waleed; El Feki, Abdelfatteh; Allagui, Mohamed Salah

2018-05-07

Cerium chloride (CeCl 3 ) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl 3 , 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days. We then examined mouse behavior, brain tissue damage, and brain oxidative stress parameters. Our results revealed a significant modification in the behavior of the CeCl 3 -treated mice. In addition, CeCl 3 induced a significant increment in lipid peroxidation, carbonyl protein (PCO), and advanced oxidation protein product levels, as well as a significant reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Acetylcholinesterase (AChE) activity remarkably increased in the brain of CeCl 3 -treated mice. Histopathological observations confirmed these results. Curcuma longa attenuated CeCl 3 -induced oxidative stress and increased the activities of antioxidant enzymes. It also decreased AChE activity in the CeCl 3 -damaged mouse brain that was confirmed by histopathology. In conclusion, this study suggests that Curcuma longa has a neuroprotective effect against CeCl 3 -induced damage in the brain.

Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney.

Science.gov (United States)

Mohebbati, Reza; Shafei, Mohammad Naser; Soukhtanloo, Mohammad; Mohammadian Roshan, Noema; Khajavi Rad, Abolfazl; Anaeigoudari, Akbar; Hosseinian, Sara; Karimi, Sareh; Beheshti, Farimah

2016-01-01

Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney. The animals were divided into 6 groups: control (CO), ADR, Adriamycin+ Vitamin C (ADR+VIT C), C. longa extract+ Adriamycin (C.LE+ADR), N. sativa extract+ Adriamycin (N.SE+ADR) and C. longa extract+ N. sativa extract + Adriamycin (N.S+C.L+ADR). ADR (5mg/kg) was injected intravenously, whereas VITC (100mg/kg) and extract of C. longa (1000mg/kg) and N. sativa (200mg/kg) were administrated orally. Finally, the renal tissue, urine and blood samples were collected and submitted to measure of redox markers, osmolarity and renal index. The renal content of total thiol and superoxide dismutase (SOD) activity significantly decreased and Malondialdehyde (MDA) concentration increased in Adriamycin group compared to control group. The renal content of total thiol and SOD activity significantly enhanced and MDA concentration reduced in treated-mixed extract of C. longa and N. sativa along with ADR group compared to ADR group. The mixed extract did not restore increased renal index percentage induced by ADR. There also was no significant difference in urine and serum osmolarity between the groups. hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced oxidative stress and mixed administration of the extracts enhanced the aforementioned therapeutic effect.

The evolution of the Luz y Fuerza del Centro substations. Volume 2; Evolucion de las subestaciones de Luz y Fuerza del Centro. Volumen 2

Energy Technology Data Exchange (ETDEWEB)

Carranza Ramirez, Sergio [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

1997-12-31

This document cites historical background of how the Luz y Fuerza del Centro substations have evolved up to nowadays. A brief description is made of one electric substation, the substation design criteria are mentioned, since it must comply with the requirements of reliability, service continuity, service quality, economy, geographical location, just for mentioning some of them. The more utilized arrangements of the Luz y Fuerza del Centro substations are described. In the same manner, the remote control substations are described mentioning the main elements of this type of substations. Mention is made also of the technological incorporations that have been made to the substations and the perspectives there are from these. One line diagrams of the electric substations are shown, as well as from power plant substations [Espanol] Este documento cita antecedentes historicos de como han evolucionando las subestaciones de Luz y Fuerza del Centro hasta hoy en dia. Se realiza una breve descripcion de una subestacion electrica, se mencionan los criterios de diseno de una subestacion, ya que debe cumplir con los requisitos de confiabilidad, continuidad, calidad del servicio, economia, situacion geografica, por mencionar algunos de estos. Se describen los arreglos de las subestaciones mas utilizados por Luz y Fuerza del Centro. De igual manera se describen las subestaciones telecontroladas mencionando los principales elementos de este tipo de subestaciones. Se mencionan las incorporaciones tecnologicas que se han realizado a las subestaciones y las perspectivas que se tienen de estas. Se muestran diagramas unifilares de subestaciones electricas, al igual que se muestran las plantas de las subestaciones

Effect of Hydroalcholic Extract of Curcuma longa on Adriamycin-Induced Renal Damage in Rats

OpenAIRE

R. Mohebbati; A.A. Abbasnezhad; A. Khajavi Rad; M. Haghshenas; M.R. Khazdeir

2016-01-01

Aims: Adriamycin is one of the anti-cancer medications. Nevertheless, the medication causes renal damage. Curcuma longa has anti-inflammatory and anti-oxidant effects. The aim of this study was to determine the effects of hydroalcoholic extract of Curcuma longa on renal damage due to Adriamycin in the rat. Materials & Methods: In the experimental study, 32 male Wistar rats were studied. Via simple random method, the rats were divided into four groups including control, Adriamycin (5mg/Kg)...

Chemotaxonomic Characterization and in-Vitro Antimicrobial and Cytotoxic Activities of the Leaf Essential Oil of Curcuma longa Grown in Southern Nigeria

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Emmanuel E. Essien

2015-12-01

Full Text Available Curcuma longa (turmeric has been used in Chinese traditional medicine and Ayurvedic medicine for many years. Methods: The leaf essential oil of C. longa from southern Nigeria was obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry (GC-MS. The essential oil was screened for in vitro antibacterial, antifungal, and cytotoxic activities. The major components in C. longa leaf oil were ar-turmerone (63.4%, α-turmerone (13.7%, and β-turmerone (12.6%. A cluster analysis has revealed this to be a new essential oil chemotype of C. longa. The leaf oil showed notable antibacterial activity to Bacillus cereus and Staphylococcus aureus, antifungal activity to Aspergillus niger, and cytotoxic activity to Hs 578T (breast tumor and PC-3 (prostate tumor cells. The ar-turmerone-rich leaf essential oil of C. longa from Nigeria has shown potent biological activity and therapeutic promise.

Chemotaxonomic Characterization and in-Vitro Antimicrobial and Cytotoxic Activities of the Leaf Essential Oil of Curcuma longa Grown in Southern Nigeria

Science.gov (United States)

Essien, Emmanuel E.; Newby, Jennifer Schmidt; Walker, Tameka M.; Setzer, William N.; Ekundayo, Olusegun

2015-01-01

Curcuma longa (turmeric) has been used in Chinese traditional medicine and Ayurvedic medicine for many years. Methods: The leaf essential oil of C. longa from southern Nigeria was obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry (GC-MS). The essential oil was screened for in vitro antibacterial, antifungal, and cytotoxic activities. The major components in C. longa leaf oil were ar-turmerone (63.4%), α-turmerone (13.7%), and β-turmerone (12.6%). A cluster analysis has revealed this to be a new essential oil chemotype of C. longa. The leaf oil showed notable antibacterial activity to Bacillus cereus and Staphylococcus aureus, antifungal activity to Aspergillus niger, and cytotoxic activity to Hs 578T (breast tumor) and PC-3 (prostate tumor) cells. The ar-turmerone-rich leaf essential oil of C. longa from Nigeria has shown potent biological activity and therapeutic promise. PMID:28930216

Genetic diversity of "Pimenta Longa" genotypes (Piper spp., Piperaceae) of the Embrapa Acre germplasm collection

OpenAIRE

Wadt, Lúcia Helena de Oliveira; Ehringhaus, Christiane; Kageyama, Paulo Yoshio

2004-01-01

The commonly known Pimenta longa is a commercially valuable natural resource found wild in Acre, Brazil. Specifically, three Piperaceae species with contested taxonomic status were studied, Piper hispidinervum, Piper aduncum, and Piper hispidum, to assesses the inter- and intra-specific genetic relationship of 49 Piper genotypes kept in the Pimenta longa germplasm collection at Embrapa Acre, using sixty six Random Amplified Polymorphic DNA (RAPD) markers. The DNA polymorphism level detected w...

Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

DEFF Research Database (Denmark)

Dao, Trong Tuan; Won, Ho Keun; Kim, Eun Hee

2012-01-01

The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong...... against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses....

Study on Quality Standard of Processed Curcuma Longa Radix

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Zhimin Chen

2017-01-01

Full Text Available To control the quality of Curcuma Longa Radix by establishing quality standards, this paper increased the contents of extract and volatile oil determination. Meanwhile, the curcumin was selected as the internal marker, and the relative correlation factors (RCFs of demethoxycurcumin and bisdemethoxycurcumin were established by high performance liquid chromatography (HPLC. The contents of multicomponents were calculated based on their RCFs. The rationality and feasibility of the methods were evaluated by comparison of the quantitative results between external standard method (ESM and quantitative analysis of multicomponents by single-marker (QAMS. Ethanol extracts ranged from 9.749 to 15.644% and the mean value was 13.473%. The volatile oil ranged from 0.45 to 0.90 mL/100 g and the mean value was 0.66 mL/100 g. This method was accurate and feasible and could provide a reference for further comprehensive and effective control of the quality standard of Curcuma Longa Radix and its processed products.

Study on Quality Standard of Processed Curcuma Longa Radix

Science.gov (United States)

Zhao, Yongfeng; Quan, Liang; Zhou, Haiting; Cao, Dong; Li, Wenbing; Yang, Zhuo

2017-01-01

To control the quality of Curcuma Longa Radix by establishing quality standards, this paper increased the contents of extract and volatile oil determination. Meanwhile, the curcumin was selected as the internal marker, and the relative correlation factors (RCFs) of demethoxycurcumin and bisdemethoxycurcumin were established by high performance liquid chromatography (HPLC). The contents of multicomponents were calculated based on their RCFs. The rationality and feasibility of the methods were evaluated by comparison of the quantitative results between external standard method (ESM) and quantitative analysis of multicomponents by single-marker (QAMS). Ethanol extracts ranged from 9.749 to 15.644% and the mean value was 13.473%. The volatile oil ranged from 0.45 to 0.90 mL/100 g and the mean value was 0.66 mL/100 g. This method was accurate and feasible and could provide a reference for further comprehensive and effective control of the quality standard of Curcuma Longa Radix and its processed products. PMID:29375640

APLICACIÓN DE LA ESPECTROFOTOMETRÍA ULTRAVIOLETA PARA DETERMINAR EL OXÍGENO DISUELTO EN AGUA POR EL MÉTODO WINKLER

OpenAIRE

Ramírez T., Gustavo

1992-01-01

Se utilizó la espectrofotometría ultravioleta en reemplazo de la titulación convencional con tiosulfato de sodio para determinar el oxígeno disuelto en aguas naturales por el método Winkler. La determinación del oxígeno en aguas de diferente salinidad (Río Manzanares, Ciénaga Grande y Bahía de Santa Marta) no mostró diferencias estadísticas significativas (p

Ultra B2 - Promoção de ligações covalentes do colágeno corneal (Corneal cross-linking) no tratamento de ceratocone: resultados preliminares

OpenAIRE

Jankov, Mirko R; Hafezi, Farhad; Beko, Maja; Ignjatovic, Zora; Djurovic, Branislav; Markovic, Vujica; Schor, Paulo

2008-01-01

OBJETIVO: Apresentar os resultados visuais e ceratométricos, seis meses após tratamento foto-terapêutico com luz ultravioleta (UV) e vitamina B2 (Ultra B2), em pacientes com ceratocone progressivo. MÉTODOS: Vinte e cinco olhos de 20 pacientes (15 homens e 5 mulheres) com ceratocone progressivo, determinado pelo aumento de curvatura em exames seriados de topografia corneal, nos últimos seis meses foram avaliados. Acuidade visual não corrigida (UVA), acuidade visual melhor corrigida com óculos ...

POTENCIAL FISIOLÓGICO DE ESPÉCIES OLERÍCOLAS SUBMETIDAS A DIFERENTES ESPECTROS DE LUZ

Directory of Open Access Journals (Sweden)

Mauricio Ferrari

2016-10-01

Full Text Available O objetivo do trabalho foi avaliar o efeito de diferentes espectros de luz sobre o potencial fisiológico de espécies olerícolas. O experimento foi conduzido em delineamento inteiramente casualizado, no esquema fatorial três por cinco, com quatro repetições. As três espécies testadas foram alface (Lactuca sativa L., rúcula (Eruca sativa Mill. e couve chinesa (Brassica rapa var. pekinensis. Os cinco espectros de luz utilizados foram: vermelho, azul, amarelo, branco e ausência de luz. O teste de germinação foi conduzido em germinador tipo BOD, com temperatura constante de 25°C. Para a alface o espectro azul revela efeito negativo sobre as variáveis primeira contagem, percentual de germinação e comprimento de radícula. Para espécies de rúcula e couve chinesa, o espectro de luz vermelha e amarela apresentaram os melhores resultados para as variáveis estudadas.

Efeitos da aplicação do L.A.S.E.R. HeNe e do ultravioleta B no vitiligo

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Ana Carolina Brandt de Macedo

Full Text Available INTRODUÇÃO: O vitiligo é uma doença crônica despigmentante da pele, ocasionada pela perda funcional dos melanócitos da epiderme. Este estudo teve como objetivo comparar os efeitos da aplicação do L.A.S.E.R. HeNe e do ultravioleta B em pacientes com vitiligo. MÉTODO: Foram selecionados 22 pacientes (11 mulheres e 11 homens, com idade entre 12 e 60 anos (31,68 ± 16,29. Os pacientes foram distribuídos aleatoriamente, de acordo com a ordem de comparecimento no serviço e foram divididos randomicamente em dois grupos: o grupo A (n = 12, submetido à aplicação do L.A.S.E.R. HeNe, para o qual a técnica utilizada foi a pontual com aproximadamente 3 cm de distância entre cada ponto, perpendicularmente à pele, e o grupo B (n = 10, exposto ao Ultravioleta B, aplicado de forma perpendicular com 10 cm de afastamento da pele do paciente. Para mensuração da área tratada, utilizou-se o programa AUTOCAD 2002, no qual foi delimitada a borda da mácula em fotos tiradas no início e no fim do tratamento. RESULTADOS: Inicialmente, no grupo A, a área era de 4,87 cm² ± 3,70 e, após a aplicação, foi de 4,15 cm² ± 2,89, com diferença média de 0,72 cm² (1,89. No grupo B, verificou-se que antes da aplicação a média era de 5,36 cm² ± 6,36 e, a após a aplicação, foi de 4,43 cm² ± 5,17, com diferença média de 0,92 cm² ± 1,29. CONCLUSÃO: Ambos os aparelhos obtiveram resultados significativos na redução da mácula, com maior redução no grupo da ultravioleta.

Effects of Curcuma longa Extract on Telomerase Activity in Lung and Breast Cancer Cells

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Nosratollah Zarghami

2014-10-01

Full Text Available Background: The purpose of this study is to evaluate the effect of Curcuma longa extract on the telomerase gene expression in QU-DB lung cancer and T47D breast cancer cell lines. Materials and Methods: The present study is an experimental research. Using 3 different phases n-hexane, dichloromethane and methanol, total extract of Curcuma longa in a serial dilution was prepared and three phases was analyzed for determining which phase has more curcuminoids. Then the extract cytotoxicity effect was tested on breast cancer cell line (T47D, and lung cancer cell line (QU-DB by 24, 48 and 72 h MTT (Dimethyl thiazolyl diphenyl tetrazolium assay. Then, the cells were treated with serial concentrations of the extract. Finally, total protein was extracted from the control and test groups, its quantity was determined and telomeric repeat amplification protocol (TRAP assay was performed for measurement of possible inhibition of the telomerase activity. Results: Cell viability and MTT-based cytotoxicity assay show that the total extract of Curcuma longa has cytotoxic effect with different IC50s in breast and lung cancer cell lines. Analysis of TRAP assay also shows a significant reduction in telomerase activity on both cancer cells with different levels. Conclusion: Curcuma longa extract has anti-proliferation and telomerase inhibitory effects on QU-DB lung cancer and T47D breast cancer cells with differences in levels of telomerase inhibition.

Histological and immunohistochemical effects of Curcuma longa on activation of rat hepatic stellate cells after cadmium induced hepatotoxicity.

Science.gov (United States)

El-Mansy, A A; Mazroa, S A; Hamed, W S; Yaseen, A H; El-Mohandes, E A

2016-01-01

The liver is a target for toxic chemicals such as cadmium (Cd). When the liver is damaged, hepatic stellate cells (HSC) are activated and transformed into myofibroblast-like cells, which are responsible for liver fibrosis. Curcuma longa has been reported to exert a hepato-protective effect under various pathological conditions. We investigated the effects of C. longa administration on HSC activation in response to Cd induced hepatotoxicity. Forty adult male albino rats were divided into: group 1 (control), group 2 (Cd treated), group 3 (C. longa treated) and group 4 (Cd and C. longa treated). After 6 weeks, liver specimens were prepared for light and electron microscopy examination of histological changes and immunohistochemical localization of alpha smooth muscle actin (αSMA) as a specific marker for activated HSC. Activated HSC with a positive αSMA immune reaction were not detected in groups 1 and 3. Large numbers of activated HSC with αSMA immune reactions were observed in group 2 in addition to Cd induced hepatotoxic changes including excess collagen deposition in thickened portal triads, interlobular septa with hepatic lobulation, inflammatory cell infiltration, a significant increase in Kupffer cells and degenerated hepatocytes. In group 4, we observed a significant decrease in HSC that expressed αSMA with amelioration of the hepatotoxic changes. C. longa administration decreased HSC activation and ameliorated hepatotoxic changes caused by Cd in adult rats.

Effect of Gamma Irradiation on Antioxidant Activity and Curcuminoids of Curcuma longa L

International Nuclear Information System (INIS)

Thongphasuk, Piyanuch; Thongphasuk, Jarunee; Kulchanapakawat, Tiwat; Sajjabut, Surasak; Pongpat, Suchada; Eamsiri, Jaruratana

2007-08-01

Full text: Gamma irradiation at the dose of 10 kGy is one of the methods to reduce microbial contamination of medicinal herbs. Since irradiation may also affect active compounds of the herbs, the objective of this research was to study the effect of gamma irradiation (10 kGy) on antioxidant activity and curcuminoids contents of Curcuma longa L. DPPH (1,1-diphenyl-2-picryl-hydrazyl H) was used to study antioxidant activity and UV-spectrophotometry was used to study curcuminoids contents. The results showed that gamma irradiation at 10 kGy did not significantly affect antioxidant activity and curcuminoids contents of C. longa

Estrés en docentes universitarios. Caso LUZ, URBE y UNICA

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Marhilde Sánchez de Gallardo

2003-01-01

Full Text Available Esta investigación de campo, tipo descriptiva, tuvo como propósito determinar el estrés en docentes universitarios activos, mediante las subvariables: situaciones estresantes, síntomas manifestados, formas de afrontamiento, personalidad típica y motivos sociales (logro, afiliación y poder. Se tomaron muestras utilizando muestreo probabilístico estratificado, de tres Universidades: Universidad del Zulia (n=187, Universidad “Dr. Rafael Belloso Chacín” (n=149, Universidad Católica “Cecilio Acosta” (n=93, participando en el estudio 429 docentes, quienes contestaron las escalas SITESTRÉS, SINTOESTRÉS, AFRONTAESTRÉS, escala de personalidad típica (de Howard L. Glazer e inventario MOSE (Salom, 1992. Subescalas logro afiliación y poder. Los coeficientes de confiabilidad (alfa de Cronbach, División por mitades, corrección Guttman fueron en promedio 0,80. Los datos recabados fueron analizados en función de la media, categorizada según baremo preestablecido, encontrándose puntajes medio bajos en la subescala SITESTRÉS para los grupos de LUZ y URBE a diferencia del grupo de la UNICA, en la categoría media alta, SINTOESTRÉS en la categoría media baja para las tres universidades, AFRONTAESTRÉS medio bajo en LUZ y URBE y medio alto en la UNICA, personalidad típica ADÉBIL en LUZ y URBE y B DÉBIL en UNICA, motivación al logro alta, afiliación media alta y poder medio bajo en LUZ y UNICA y medio alto en URBE.

The inhibitory effect of Curcuma longa extract on telomerase activity ...

African Journals Online (AJOL)

Telomerase is reactivated in lung cancer cells, the most prevalent cancer worldwide, but not normal cells. Therefore, targeting it, preferably with natural compounds derive from medicinal plant such as curcumin, could have important effect on treatment of lung cancer. Curcumin, derived from Curcuma longa rhizome, has ...

Testicular cytoprotective activities of Curcuma longa in STZ-induced ...

African Journals Online (AJOL)

This study was aimed at investigating the cytoprotective activities of Curcuma longa (Turmeric) on the histological structure of the testes in diabetic male rats. Turmeric is commonly called the golden spice, is used as a spice in cooking and also has a long history of medicinal use, dating back nearly 4000 years to the Vedic ...

Exposición a fuentes de radiación ultravioleta en los lugares y situaciones más insospechadas

OpenAIRE

Aguilera, J.

2015-01-01

Antecedentes: Existen determinadas situaciones en las que es común la exposición a fuentes de radiación ultravioleta artificial que normalmente pasa de forma asintomática para la mayoría de las personas. No obstante, existen determinadas fotodermatosis que dan lugar al paciente un grado de sensibildad muy alto a dicha exposición con respuestas anómalas a corto y medio plazo. El conocimiento tanto de la calidad espectral y la intensidad de la radiación a la que el paciente puede estar potencia...

LA RADIACIÓN ULTRAVIOLETA EN EL DOCENTE DE EDUCACIÓN FÍSICA: PREVENCIÓN DE RIESGOS LABORALES

OpenAIRE

José Rizo Agüera; Ángel Bernal Valero; Ester Hernández García

2008-01-01

Los docentes de Educación Física representan un grupo de población que se expone crónicamente a la radiación solar. "La importancia de la radiación ultravioleta (RUV) en la inducción de cáncer cutáneo fue demostrada directamente en 1959 por Blum" (Serra y Tribó, 1994, p. 329). Existen pocas investigaciones descriptivas del cuidado de la piel de los educadores físicos. El presente artículo tiene por objeto la reflexión de los riesgos que de la exposición solar se derivan en la labor docente, t...

The effect of hydro-ethanolic extract of Curcuma longa rhizome and curcumin on total and differential WBC and serum oxidant, antioxidant biomarkers in rat model of asthma.

Science.gov (United States)

Shakeri, Farzaneh; Soukhtanloo, Mohammad; Boskabady, Mohammad Hossein

2017-02-01

The effects of Curcuma longa ( C. longa ) and curcumin on total and differential WBC count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. Total and differential WBC count in the blood, NO 2 , NO 3 , MDA, SOD, CAT and thiol levels in serum were examined in control, asthma, Asthmatic rats treated with C. longa (0.75, 1.50, and 3.00 mg/ml), curcumin (0.15, 0.30, and 0.60 mg/ml), and dexamethasone (1.25 μg/ml) rats. Total and most differential WBC count, NO 2 , NO 3 and MDA were increased but lymphocytes, SOD, CAT and thiol were decreased in asthmatic animals compared to controls ( P longa and curcumin compared to asthmatic group ( P longa and curcumin ( P longa extract and its constituent curcumin in animal model of asthma was observed which suggest a therapeutic potential for the plant and its constituent on asthma.

Inhibitory effect of the essential oil of Curcuma longa L. and curcumin on aflatoxin production by Aspergillus flavus Link.

Science.gov (United States)

Ferreira, Flavio Dias; Kemmelmeier, Carlos; Arrotéia, Carla Cristina; da Costa, Christiane Luciana; Mallmann, Carlos Augusto; Janeiro, Vanderly; Ferreira, Francine Maery Dias; Mossini, Simone Aparecida Galerani; Silva, Expedito Leite; Machinski, Miguel

2013-01-15

Aflatoxins are highly toxic, mutagenic, teratogenic and carcinogenic mycotoxins. Consumption of aflatoxin-contaminated food and commodities poses serious hazards to the health of humans and animals. Turmeric, Curcuma longa L., is a native plant of Southeast Asia and has antimicrobial, antioxidant and antifungal properties. This paper reports the antiaflatoxigenic activities of the essential oil of C. longa and curcumin. The medium tests were prepared with the oil of C. longa, and the curcumin standard at concentrations varied from 0.01% to 5.0%. All doses of the essential oil of the plant and the curcumin standard interfered with mycotoxin production. Both the essential oil and curcumin significantly inhibited the production of aflatoxins; the 0.5% level had a greater than 96% inhibitory effect. The levels of aflatoxin B(1) (AFB(1)) production were 1.0 and 42.7 μg/mL, respectively, for the samples treated with the essential oil of C. longa L. and curcumin at a concentration of 0.5%. Copyright © 2012 Elsevier Ltd. All rights reserved.

Neuropharmacological profile and chemical analysis of fresh rhizome essential oil of Curcuma longa (turmeric) cultivated in Southwest Nigeria.

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Oyemitan, Idris A; Elusiyan, Christianah A; Onifade, Ayoola O; Akanmu, Moses A; Oyedeji, Adebola O; McDonald, Armando G

2017-01-01

Curcuma longa (turmeric) is commonly used as spice and also used to treat fever, cough and febrile convulsions in Nigeria. This study determined the chemical composition of the essential oil of C. longa and evaluated its neuropharmacological activity in mice. Essential oil of C. longa (EOCL) fresh rhizome was obtained by hydrodistillation and its chemical composition determined by GC-MS. Acute toxicity (LD 50 ) profile of the essential oil was determined orally (p.o.) and intraperitoneally (i.p.); and the EOCL (50-200 mg/kg, i.p.) was evaluated for its behavioural, anxiolytic, sedative and anticonvulsant activities using appropriate models in Albino mice (Vom Strain, Jos, Nigeria). Analysis of the oil showed the presence of 23 compounds with turmerone (35.9%) being the major component. The LD 50 values obtained for the mice were 2154 mg/kg, p.o., and 693 mg/kg, i.p. The EOCL (50-200 mg/kg, i.p.) caused significant (p longa species was turmerone; the oil was slightly toxic orally but moderately toxic intraperitoneally in mice; exhibited significant anxiolytic, sedative and anticonvulsant activities in mice.

Inhibition of 12/15 lipoxygenase by curcumin and an extract from Curcuma longa L.

Science.gov (United States)

Bezáková, Lýdia; Košťálová, Daniela; Obložinský, Marek; Hoffman, Peter; Pekárová, Mária; Kollárová, Renáta; Holková, Ivana; Mošovská, Silvia; Sturdík, Ernest

2014-02-01

Curcumin (diferuloylmethane) is an orange-yellow secondary metabolic compound from the rhizome of turmeric (Curcuma longa L.), a spice often found in curry powder. It is one of the major curcuminoids of turmeric. For centuries, curcumin has been used in some medicinal preparations or as a food colouring agent. A variety of enzymes that are closely associated with inflammation and cancer were found to be modulated by curcumin. This paper summarized the results of the inhibitory effect of curcumin and a Curcuma longa L. ethanolic extract on lipoxygenase from the rat lung cytosolic fraction. The positional specificity determination of arachidonic acid dioxygenation by RP- and SP-HPLC methods showed that in a purified enzyme preparation from the rat lung cytosol the specific form of lipoxygenase (LOX) is present exhibiting 12/15-LOX dual specificity (with predominant 15-LOX activity). The inhibitory activity of curcumin and Curcuma longa extract on LOX from cytosolic fraction of rat lung was expressed in the percentage of inhibition and as IC50. Lineweaver-Burk plot analysis has indicated that curcumin is the competitive inhibitor of 12/15 LOX from the rat lung cytosolic fraction.

Luz y gravedad (Reflexiones geométricas sobre cáusticas y lentes gravitacionales

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Elena Ortiz García

2011-04-01

Full Text Available Cuando los rayos de luz iluminan una taza de café en una tardesoleada, podemos observar la curva que más brilla sobre la superficie del líquido. Quizá sea ésta una oportunidad para plantearse el siguiente experimento mental: ¿cómo juegan los rayos de luz al reflejarse en diferentes “tazas” geométricas? Esta comunicación pretende proseguir esta discusión con algunas consideraciones sencillas que nos sitúen ante el fenómeno de las lentes gravitacionales, allí donde los efectos de la gravedad afectan, incluso, a la manera de propagarse de la luz, mostrando un sistema dinámico idealizado que resulta, a la vez, sencilloy (matemáticamente caótico.

Las escalas de la luz

OpenAIRE

Beckers, Benoit

2009-01-01

Variando con el paso del día y del año, la luz del Sol y del cielo modula, visual y energéticamente, los territorios, las ciudades y los edificios. ¿Cómo sintetizar y manejar en el proyecto estas informaciones donde se mezcla el azar de las nubes pasajeras con la regularidad astronómica de los trayectos solares? En cuanto a las herramientas de simulación, el mayor avance de estos últimos años se ha producido en los programas de renderización, con los cuales nos vemos forzados a construi...

The inhibitory effect of Curcuma longa extract on telomerase activity ...

African Journals Online (AJOL)

STORAGESEVER

2010-02-08

Feb 8, 2010 ... curcumin, could have important effect on treatment of lung cancer. Curcumin ... study inhibitory effect of C. longa total extract on telomerase in A549 lung cancer cell line as in vitro model of ..... If A > 2× (OD of negative control), then, telomerase activity ... radiation, chemotherapy, laser therapy, photodynamic.

Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats.

Science.gov (United States)

Nwozo, Sarah Onyenibe; Osunmadewa, Damilola Adeola; Oyinloye, Babatunji Emmanuel

2014-01-01

The present study is aimed at evaluating the protective effects of oils from Zingiber officinale (ginger) and Curcuma longa (turmeric) on acute ethanol-induced fatty liver in male Wistar rats. Ferric reducing antioxidant power activity and oxygen radical absorbance capacity of the oils were evaluated ex vivo. Rats were pretreated for 28 d with standard drug (Livolin Forte) and oils from Z. officinale and C. longa before they were exposed to 45% ethanol (4.8 g/kg) to induce acute fatty liver. Histological changes were observed and the degree of protection was measured by using biochemical parameters such as alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities. Serum triglyceride (TG) level, total cholesterol (TC) level and the effects of both oils on reduced gluthatione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and hepatic malondialdehyde (MDA) levels were estimated. Oils from Z. officinale and C. longa at a dose of 200 mg/kg showed hepatoprotection by decreasing the activities of serum enzymes, serum TG, serum TC and hepatic MDA, while they significantly restored the level of GSH as well as GST and SOD activities. Histological examination of rats tissues was related to the obtained results. From the results it may be concluded that oils from Z. officinale and C. longa (200 mg/kg) exhibited hepatoprotective activity in acute ethanol-induced fatty liver and Z. officinale oil was identified to have better effects than C. longa oil.

The Challenges of Rehabilitating the Hercilio Luz Suspension Bridge

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Hermes Carvalho

Full Text Available Abstract The Hercílio Luz suspension bridge, built in 1926, has been out of service since 1991 due to high corrosion levels and structural element impairment. A complete rehabilitation project was developed which included the replacement of the impaired items and foundation strengthening. For this, an auxiliary structure was employed to support the central span during the rehabilitation process. A carefully studied load transfer process, where the central span loading is transferred from the eye-bar towards the auxiliary structure will be performed. For this purpose, a synchronized jacking sequence will be used, which was predefined by means of numerical model analysis. All structural elements had their designs evaluated and some geometric changes were implemented. This paper presents all the methodology developed in the rehabilitation project of Hercilio Luz bridge, as well as the development stages up to the present date.

Influence of curcumin (Curcuma longa as a natural anticoccidial alternative in adult rabbits: first results

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María Eugenia Cervantes-Valencia

2015-07-01

Full Text Available Coccidiosis is one of the most common ailments in rabbits farming and is usually treated with drugs that can produce resistance; therefore, a natural alternative was sought. The objective of the current study was to evaluate the efficacy of the aqueous extract of curcumin (Curcuma longa on the excretion of oocysts of Eimeria spp. in New Zealand white rabbits. Twenty-four eight-month-old rabbits were divided into four groups of six animals to be C. longa extract administered at 0 (Control, 10, 25 or 40 mg/kg body weight (BW. Rabbit weights were recorded and faeces samples were collected on d 0, 7, 14, 21, 28, 35 and 42. The McMaster technique was used for quantifying Eimeria spp. oocysts. Results were analysed using multivariate analysis of variance for repeated observations. Statistically significant differences (P<0.05 from d 28 were observed among the Control, the group of 25 mg/kg BW and that of 40 mg/kg BW. At d 42, statistically difference (P<0.05 among the Control group and the other three groups was observed. It could be concluded that C. longa decreased Eimeria spp. oocysts excretion efficiently at a dose of 40 mg/kg BW with 80.1, 63.7 and 64.9% for d 28, 35 and 42, respectively, with reducing concentration of eggs per gram of faeces with about 20.1, 15.6 and 17.8 for d 14, 21 and 35, respectively. However, further studies are needed to assess and confirm the antiparasitic activity of C. longa.

Quantitative determination of curcuminoids from the Roots of Curcuma longa, Curcuma species and dietary supplements using an UPLC-UV-MS method

Science.gov (United States)

A simple, fast UPLC-UV-MS method was developed for the determination of curcuminoids from roots of Curcuma longa L., Curcuma species (C. zedoaria, C. phaecaulis, C. wenyujin and C. kwangsiensis) and dietary supplements claiming to contain C. longa. The total content of curcuminoids (curcumin, desmet...

O tratado sobre a luz de Huygens: comentários

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Sonia Krapas

2011-01-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2011v28n1p123 Huygens é conhecido no ensino introdutório de Física por dar conta da refração segundo um modelo ondulatório. Livros didáticos lhe rendem homenagens atribuindo seu nome a um princípio, mas em sua obra máxima, Tratado sobre a luz, é possível se ver muito mais: sua inventividade na defesa de um modelo ondulatório para a luz como alternativo ao modelo corpuscular. Neste trabalho, tenta-se evidenciar o raciocínio de Huygens, mostrando que, apesar de ter sido publicada há mais de trezentos anos, a obra está escrita numa linguagem relativamente acessível.

In Vitro Antioxidant Activity of N-Butanol Extract Of Curcuma Longa

African Journals Online (AJOL)

Bulus et al.

of these findings in the usage of Curcuma longa as food additives ... because active principles from these plants are thought to play important roles in ... turmeric, possesses wide spectrum of biological properties including .... nutrition and chemotherapy. ... their staple food and also in the management of local ailments.

Cultivo in vitro de cana-de-açúcar exposta a diferentes fontes de luz

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Felipe Aarão Maluta

2013-09-01

Full Text Available O objetivo deste trabalho foi avaliar o efeito de diferentes comprimentos de onda no desenvolvimento in vitro de mudas de cana-de-açúcar. Explantes foram submetidos a quatro tratamentos de diodos emissores de luz (LED: 100% azul; 70% azul + 30% vermelha; 30% azul + 70% vermelha; 100% vermelha, além do controle com lâmpada fluorescente branca. As plântulas foram avaliadas quanto a: número de brotações; altura; massa de matéria fresca e seca; e conteúdo de carotenoides e das clorofilas a e b. Observou-se desmanche dos tilacoides nos cloroplastos, proporcional ao aumento na incidência de luz vermelha. O porte das mudas diminui com o aumento na incidência de luz vermelha.

The Inhibitory Effects of Curcuma longa L. Essential Oil and Curcumin on Aspergillus flavus Link Growth and Morphology

Science.gov (United States)

Mossini, Simone Aparecida Galerani; Ferreira, Francine Maery Dias; Arrotéia, Carla Cristina; da Costa, Christiane Luciana; Nakamura, Celso Vataru; Machinski Junior, Miguel

2013-01-01

The essential oil from Curcuma longa L. was analysed by GC/MS. The major components of the oil were ar-turmerone (33.2%), α-turmerone (23.5%) and β-turmerone (22.7%). The antifungal activities of the oil were studied with regard to Aspergillus flavus growth inhibition and altered morphology, as preliminary studies indicated that the essential oil from C. longa inhibited Aspergillus flavus Link aflatoxin production. The concentration of essential oil in the culture media ranged from 0.01% to 5.0% v/v, and the concentration of curcumin was 0.01–0.5% v/v. The effects on sporulation, spore viability, and fungal morphology were determined. The essential oil exhibited stronger antifungal activity than curcumin on A. flavus. The essential oil reduced the fungal growth in a concentration-dependent manner. A. flavus growth rate was reduced by C. longa essential oil at 0.10%, and this inhibition effect was more efficient in concentrations above 0.50%. Germination and sporulation were 100% inhibited in 0.5% oil. Scanning electron microscopy (SEM) of A. flavus exposed to oil showed damage to hyphae membranes and conidiophores. Because the fungus is a plant pathogen and aflatoxin producer, C. longa essential oil may be used in the management of host plants. PMID:24367241

The Inhibitory Effects of Curcuma longa L. Essential Oil and Curcumin on Aspergillus flavus Link Growth and Morphology

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Flávio Dias Ferreira

2013-01-01

Full Text Available The essential oil from Curcuma longa L. was analysed by GC/MS. The major components of the oil were ar-turmerone (33.2%, α-turmerone (23.5% and β-turmerone (22.7%. The antifungal activities of the oil were studied with regard to Aspergillus flavus growth inhibition and altered morphology, as preliminary studies indicated that the essential oil from C. longa inhibited Aspergillus flavus Link aflatoxin production. The concentration of essential oil in the culture media ranged from 0.01% to 5.0% v/v, and the concentration of curcumin was 0.01–0.5% v/v. The effects on sporulation, spore viability, and fungal morphology were determined. The essential oil exhibited stronger antifungal activity than curcumin on A. flavus. The essential oil reduced the fungal growth in a concentration-dependent manner. A. flavus growth rate was reduced by C. longa essential oil at 0.10%, and this inhibition effect was more efficient in concentrations above 0.50%. Germination and sporulation were 100% inhibited in 0.5% oil. Scanning electron microscopy (SEM of A. flavus exposed to oil showed damage to hyphae membranes and conidiophores. Because the fungus is a plant pathogen and aflatoxin producer, C. longa essential oil may be used in the management of host plants.

The inhibitory effects of Curcuma longa L. essential oil and curcumin on Aspergillus flavus link growth and morphology.

Science.gov (United States)

Dias Ferreira, Flávio; Mossini, Simone Aparecida Galerani; Dias Ferreira, Francine Maery; Arrotéia, Carla Cristina; da Costa, Christiane Luciana; Nakamura, Celso Vataru; Machinski, Miguel

2013-01-01

The essential oil from Curcuma longa L. was analysed by GC/MS. The major components of the oil were ar-turmerone (33.2%), α -turmerone (23.5%) and β -turmerone (22.7%). The antifungal activities of the oil were studied with regard to Aspergillus flavus growth inhibition and altered morphology, as preliminary studies indicated that the essential oil from C. longa inhibited Aspergillus flavus Link aflatoxin production. The concentration of essential oil in the culture media ranged from 0.01% to 5.0% v/v, and the concentration of curcumin was 0.01-0.5% v/v. The effects on sporulation, spore viability, and fungal morphology were determined. The essential oil exhibited stronger antifungal activity than curcumin on A. flavus. The essential oil reduced the fungal growth in a concentration-dependent manner. A. flavus growth rate was reduced by C. longa essential oil at 0.10%, and this inhibition effect was more efficient in concentrations above 0.50%. Germination and sporulation were 100% inhibited in 0.5% oil. Scanning electron microscopy (SEM) of A. flavus exposed to oil showed damage to hyphae membranes and conidiophores. Because the fungus is a plant pathogen and aflatoxin producer, C. longa essential oil may be used in the management of host plants.

Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review.

Science.gov (United States)

Hosseini, Azar; Hosseinzadeh, Hossein

2018-03-01

Curcuma longa is a rhizomatous perennial herb that belongs to the family Zingiberaceae, native to South Asia and is commonly known as turmeric. It is used as herbal remedy due to the prevalent belief that the plant has medical properties. C. longa possesses different effects such as antioxidant, anti-tumor, antimicrobial, anti-inflammatory, wound healing, and gastroprotective activities. The recent studies have shown that C. longa and curcumin, its important active ingredient, have protective effects against toxic agents. In this review article, we collected in vitro and animal studies which are related to protective effects of turmeric and its active ingredient against natural and chemical toxic agents. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Einstein, la luz, el espacio-tiempo y los cuantos

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Fernando Barbero G., J.

2015-10-01

Full Text Available The study of light, its nature and properties was a central topic in the works of Albert Einstein. This paper discusses the role of light in the formulation of special relativity, in particular as a tool to provide operational definitions of the basic kinematic concepts. It also discusses the role of light in understanding general relativity and ends by briefly considering its quantum behaviour.El estudio de la luz, su naturaleza y sus propiedades ocupó un lugar central en los trabajos de Albert Einstein. En este artículo se discute el papel de la luz en la formulación de la relatividad especial, en particular como instrumento para la definición operacional de las magnitudes cinemáticas básicas, se muestra su importancia para la comprensión de la relatividad general y, por último, se considera brevemente su comportamiento cuántico.

Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum

Science.gov (United States)

Zhang, Fusheng; Chen, Qin; Chen, Cheng; Yu, Xiaorui; Liu, Qingya; Bao, Jinku

2018-01-01

Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase. PMID:29543859

Luz natural na micropropagação do abacaxizeiro (Ananas comosus L. Merr)

OpenAIRE

Bortolotti da Silva, Adriano; Pasqual, Moacir; Mauro de Castro, Evaristo; Yuriko Miyata, Luzia; Amaral de Melo, Lucas; Tavares Braga, Francyane

2008-01-01

Brotações de Ananas comosus cv. Imperial, foram enraizadas in vitro em diferentes condições ambientais (luz artificial e natural) e após dois meses as plântulas foram transferidas para substrato comercial (Plantmax®) em casa de vegetação. O crescimento das plantas e anatomia foliar foram avaliados em diferentes tempos (0, 7, 15, 30 e 60 dias) do processo de aclimatização. O emprego de luz natural durante a fase de enraizamento in vitro proporciona melhor desempenho agronômico e anatômico das ...

Extraction of curcumin from Curcuma longa L. using ultrasound assisted supercritical carbon dioxide

Science.gov (United States)

Kimthet, Chhouk; Wahyudiono, Kanda, Hideki; Goto, Motonobu

2017-05-01

Curcumin is one of phenolic compounds, which has been recently shown to have useful pharmacological properties such as anti-inflammatory, anti-bacterial, anti-carcinogenic, antifungal, and antimicrobial activities. The objective of this research is to extract the curcumin from Curcuma longa L. using ultrasound assisted supercritical carbon dioxide extraction (USC-CO2). The extraction was performed at 50°C, 25 MPa, CO2 flow rate of 3 mL/min with 10% cosolvent. The result of extraction, thermogravimetry (TG), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) showed that ultrasound power could disrupt cell wall and release the target compounds from Curcuma longa L. USC-CO2 could provide higher curcumin content in the extracts and faster extraction compared to SC-CO2 extraction without ultrasound.

Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus.

Science.gov (United States)

Yuksel, Nilay; Bilgihan, Kamil; Hondur, Ahmet M

2011-12-01

To describe a case of herpetic keratitis after corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A for progressive keratoconus. A 31-year-old woman with rapidly progressive keratoconus in the left eye was treated with CXL. Four days postoperatively, a dendritic ulcer developed in the treated eye. The diagnosis was confirmed with polymerase chain reaction analysis of the corneal swab for herpes simplex. The patient had no prior history of herpetic eye disease or cold sores. The keratitis resolved in 10 days with treatment. At 1 month, the visual acuity was stable, but a mild superficial opacity was noted. Herpetic keratitis can be induced by CXL even in patients with no history of previous herpetic eye disease. Early diagnosis and proper treatment can facilitate successful management of this rare but important complication.

Luz natural en el espacio interior. Estudios de estados lumínicos en el Stata Center

Directory of Open Access Journals (Sweden)

Andrés Pinzón Latorre

2008-05-01

Full Text Available El ver, es el resultado de la interaccion entre el cerebro, las fuentes luminicas del entorno inmediato y los objetos que se observan. Los ojos perciben la luz y su encuentro con los materiales, las texturas y las formas que definen una arquitectura. Las cualidades de un estado lumínico tienen un efecto directo en la habitabilidad de un espacio interior, que será el ambiente para a lo largo del tiempo, la luz natural se interne, y se mueva a través de éste modificando su apariencia. Con el propósito de conocer y predecir la transformacion de luz en un espacio determinado, es necesario entender sus características como fenomeno natural. Mas allá de describir sus cualidades y calificar su presencia de acuerdo a los sentidos, es necesario cuantificar sus valores inherentes establecidos por cantidades y unidades cientificas desarrolladas para tal fin. Esto permitirá encontrar y aplicar metodos apropiados para corregir deficiencias en los espacios proyectados. Este articulo presenta un caso de estudio específico que atiende al tema de la luz natural, su importancia en arquitectura, y su desempeño en un espacio interior de un edificio educativo. Las actividades realizadas a diario por los usuarios de dicho espacio, son el punto de partida para reflexionar sobre el fenomeno de la luz en sí, entender su complejidad, y establecer estrategias de mejoramiento en los estados actuales de iluminación.

Morphological and molecular identification of the fish-borne metacercaria of Ascocotyle (Phagicola) longa Ransom, 1920 in Mugil liza from Argentina.

Science.gov (United States)

Martorelli, S R; Lino, A; Marcotegui, P; Montes, M M; Alda, P; Panei, C J

2012-12-21

This is the first report of Ascocotyle (Phagicola) longa Ransom, 1920 (Digenea: Heterophyidae) in Argentina confirmed by morphological and molecular studies. The metacercaria was found encysted in myotomal musculature, heart and mesentery of the mullet Mugil liza (Pisces: Mugilidae) from Samborombon bay. We provide a morphological description of the metacercaria which we identified using species-specific primers for A. (Phagicola) longa and nucleotid sequence. This worldwide parasite has been reported as one of the causative agents of heterophyiosis, an emerging fish-borne disease of humans, contracted by the consumption of raw mullet. The discovery of A. (Phagicola) longa in Argentina represents a warning of the potentially great impact of this parasite on public health. Copyright © 2012 Elsevier B.V. All rights reserved.

The process of implantation of the 'Programa Luz para Todos' in Ubatuba, Sao Paulo; O processo de implantacao do Programa Luz para Todos em Ubatuba, Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Fernando Selles; Yoshino, Shinji [Furnas Centrais Eletricas, Sao Paulo, SP (Brazil)], Emails: fselles@uol.com.br, shinji.yoshino@uol.com.br; Ribeiro, Tina Bimestre Selles [Universidade de Sao Paulo (IEE-USP), SP (Brazil). Inst. de Eletrotecnica e Energia], E-mail: tina@iee.usp.br

2009-07-01

The municipality of Ubatuba is covered by a rain forest Mata Atlantica preserved in most of the territory. There are many communities that demand electricity in this area, including traditional communities like culture named 'caicara' and the remnants of slaves from Brazil colony named 'quilombos'. They are all very poor and are involved by the interest of environmental agencies. The process of rural electrification in Ubatuba, through the 'Programa Luz para Todos' found difficult to overcome issues of regularization of habitations particularly environmental issues. This work shows that solutions were found through negotiation between the parts, intermediated by an officer known as 'Agente Luz para Todos'. It shows also that without the participation of this agent would have been very difficult exceed some of the barriers. (author)

AUMENTO DEL ÍNDICE SOLAR ULTRAVIOLETA CON LA ALTURA SOLAR ULTRAVIOLET INDEX INCREASE WITH ALTITUDE

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Miguel Rivas A

2008-09-01

Full Text Available En este trabajo se presentan los resultados obtenidos al realizar comparaciones entre mediciones experimentales de Índice solar ultravioleta (IUV obtenido a partir de datos experimentales y también de resultados teóricos proveniente del cálculo del IUV mediante el modelo TUV (modelo ultravioleta troposféricol. En especial se destacan los aumentos de la irradianza solar ultravioleta B (UVB 280-320 nm que se reciben a nivel del suelo debido a los aumentos de la altitud del lugar sobre el nivel del mar (efecto altitudinal. Los cálculos mediante el modelo TUV se realizaron en un período comprendido entre los años 1996-2003, introduciendo los parámetros de los lugares geográficos en que se hicieron las mediciones experimentales. Dado que una de las variables importantes de la que depende el IUV es la altitud sobre el nivel del mar y considerando que la zona norte de Chile es un lugar con características especiales para realizar este tipo de estudios, es que se han realizado experimentos para medir la irradianza solar UVB entre 0-3.200 m de altura, y a partir de estos datos se ha obtenido el IUV. La importancia de estos resultados radica en el hecho que a partir de ellos se pueden cuantificar el incremento de la irradianza UVB por cada 1.000 m de altitud sobre el nivel del mar. Un número creciente de personas se desplazan continuamente entre el nivel del mar y altitudes cercanas a los 5.000 m, debido a trabajos relacionados con: minería, turismo, transporte. En todos estos casos estas personas reciben importantes incrementos de irradianza solar UV, que pueden afectar gravemente su salud si no se informan de los riesgos para que puedan tomar precauciones.In this work we present results from ultraviolet solar index (IUV comparisons between values obtained from experimental measurements, with theoretical results obtained from tropospherical ultraviolet model (TUV. It is important to emphasise the observed increase in solar ultraviolet B (UVB

Anticoccidial activity of Curcuma longa L. in broilers

OpenAIRE

Abbas,Rao Zahid; Iqbal,Zafar; Khan,Muhammad Nisar; Zafar,Muhammad Arif; Zia,Muhammad Anjum

2010-01-01

Comparative efficacy of turmeric (Curcuma longa L.) crude powder and salinomycin sodium on the occurrence of coccidiosis and growth performance of broiler was evaluated. A total of 90, day-old chicks were randomly divided into six groups. From first day onward, ration was supplemented with 1, 2 and 3 % turmeric powder in groups 2, 3 and 4, respectively, group 1 received salinomycin sodium @ 12 g 50 kg-1 feed while groups 5 and 6 were kept as infected un-medicated and uninfected un-medicated c...

LA RADIACIÓN ULTRAVIOLETA EN EL DOCENTE DE EDUCACIÓN FÍSICA: PREVENCIÓN DE RIESGOS LABORALES

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José Rizo Agüera

2008-01-01

Full Text Available Los docentes de Educación Física representan un grupo de población que se expone crónicamente a la radiación solar. "La importancia de la radiación ultravioleta (RUV en la inducción de cáncer cutáneo fue demostrada directamente en 1959 por Blum" (Serra y Tribó, 1994, p. 329. Existen pocas investigaciones descriptivas del cuidado de la piel de los educadores físicos. El presente artículo tiene por objeto la reflexión de los riesgos que de la exposición solar se derivan en la labor docente, tomando conciencia de los mismos y estableciendo una serie de recomendaciones preventivas.

Contrasting effects of ultraviolet-A and ultraviolet B exposure on induction of contact sensitivity in human skin

DEFF Research Database (Denmark)

Skov, Lone; Hansen, Henrik; Barker, J. N.

1997-01-01

Ultraviolet-B (UVB), in addition to direct effects on DNA, induces immunological changes in the skin that predispose to the development of skin cancer. Whether ultraviolet-A (UVA) induces similar changes is unknown. This effect can be investigated in humans in vivo using epicutaneous antigens...... as a model of tumour antigens. Volunteers (n = 46) were randomly assigned to received no sensitization, sensitization with the allergen diphenylcyclopropenone (DPCP) on non-UV-exposed normal skin, or sensitization with DPCP on skin exposed to three minimal erythema doses (MED) of either UVA or UVB radiation...... the immunization rate compared with sensitization on non-irradiated skin (P UVA radiation did not result in a decreased immunization rate compared with non-irradiated skin. These results indicate that in humans erythemagenic...

Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta

Science.gov (United States)

Cirigliano, D.; Vial, J.-C.; Rovira, M.

Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

Green biosynthesis of silver nanoparticles using Curcuma longa tuber powder

Science.gov (United States)

Shameli, Kamyar; Ahmad, Mansor Bin; Zamanian, Ali; Sangpour, Parvanh; Shabanzadeh, Parvaneh; Abdollahi, Yadollah; Zargar, Mohsen

2012-01-01

Green synthesis of noble metal nanoparticles is a vastly developing area of research. Metallic nanoparticles have received great attention from chemists, physicists, biologists, and engineers who wish to use them for the development of a new-generation of nanodevices. In this study, silver nanoparticles were biosynthesized from aqueous silver nitrate through a simple and eco-friendly route using Curcuma longa tuber-powder extracts, which acted as a reductant and stabilizer simultaneously. Characterizations of nanoparticles were done using different methods, which included ultraviolet-visible spectroscopy, powder X-ray diffraction, transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray fluorescence spectrometry, and Fourier-transform infrared spectroscopy. The ultraviolet-visible spectrum of the aqueous medium containing silver nanoparticles showed an absorption peak at around 415 nm. Transmission electron microscopy showed that mean diameter and standard deviation for the formation of silver nanoparticles was 6.30 ± 2.64 nm. Powder X-ray diffraction showed that the particles are crystalline in nature, with a face-centered cubic structure. The most needed outcome of this work will be the development of value-added products from C. longa for biomedical and nanotechnology-based industries. PMID:23341739

Fresnel: O formulador matemático da teoria ondulatória da luz

OpenAIRE

Bassalo, José Maria Filardo

1988-01-01

Neste artigo, apresentamos alguns aspectos da vida de Fresnel, engenheiro e físico francês que se notabilizou pela formulação matemática da teoria ondulatória da luz, e cujo bicentenário de nascimento transcorre neste ano de 1988. Realçamos, neste trabalho, suas principais pesquisas relacionadas com o estudo da difração, dupla-refração e reflexão da luz, nas quais utilizou a idéia revolucionária de transversalidade da onda luminosa para deduzir equações, as quais explicaram alg...

Effects of topical application of Curcuma longa extract in the treatment of early periodontal diseases

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Vikrant Sharma

2016-01-01

Full Text Available Background: Treatment of plaque-induced periodontal disease is largely based on the mechanical debridement of the tooth surface and meticulous maintenance of oral hygiene thereafter. Various chemical plaque control agents are used as adjuncts along with the mechanical plaque control methods for this treatment. Most of these chemical plaque control agents have varied side effects. This has led to the search of natural products which are highly effective in controlling plaque microbes while being biocompatible. Turmeric is one such well-known plant product, known for its varied medicinal value. Aim: The aim of this study is to evaluate the clinical efficacy of Curcuma longa oral formulation in treatment of infective inflammatory early periodontal diseases. Materials and Methods: This clinical study comprised twenty individuals presenting with clinical features of plaque-induced gingivitis and mild periodontitis. Three groups were randomly made in mouth of each patient selected for the study. Group I was treated with scaling and root planing (SCRP only. Group II was treated with SCRP plus C. longa oral formulation topical application for 2 weeks. Group III was treated only with topical application of C. longa extract oral formulation for 2 weeks. Gingival index, sulcus bleeding index, and plaque index were scored in each group before and after the treatment. Results: The results showed statistically significant improvement with respect to all the clinical parameters in all the three groups. However, Group II showed the maximum improvement (P < 0.001, followed by Group I (P < 0.001 and Group III (P < 0.05. The intergroup difference between the three groups for the improvements in clinical parameters was statistically nonsignificant. Conclusion: The oral formulation containing C. longa extract is effective in treating early infective-inflammatory periodontal diseases not only when used as an adjunct to SCRP but also when used alone.

Brief history and objectives of the Laboratorio Nacional de Luz Sincrotron

International Nuclear Information System (INIS)

Silva, C.E.T.G. da

1988-01-01

The construction in Brazil of a synchrotron light source was first discussed in 1981. The brief history and objectives of the Laboratorio Nacional de Luz Sincrotron are presented and discussed. (A.C.A.S.) [pt

Luz e tempo na melancolia I

Directory of Open Access Journals (Sweden)

Cláudio Soares Braga Furtado

2009-12-01

Full Text Available A comparação entre as artes possibilita figurar o tempo como elemento comum entre a gravura renascentista de Dürer, a escultura romana de Laocoonte e o conto de Guimarães Rosa. A partir da leitura dessas artes distantes em forma, meios, época e lugar, descobrem-se mistérios aludidos em sutis sinais, que, se ainda não despertos na consciência criativa, estimulam interpretações. O papel da luz como unificadora das entidades tempo/espaço restabelece o princípio clássico da ut pictura poesis na leitura moderna.

Plasticidad fenotípica de poblaciones de chile silvestre (Capsicum annuum var. glabriusculum) en respuesta a disponibilidad de luz

OpenAIRE

Hernández-Verdugo, Sergio; González-Sánchez, Ramón A.; Porras, Flor; Parra-Terraza, Saúl; Valdez-Ortiz, Angel; Pacheco-Olvera, Antonio; López-España, Ricardo Guillermo

2015-01-01

La plasticidad fenotípica permite a las plantas lidiar con ambientes heterogéneos. Capsicum annuum silvestre es un valioso recurso genético que habita en sitios que difieren en la disponibilidad de luz. Evaluamos la variación genética entre poblaciones, la plasticidad fenotípica y su variación en respuesta a tres niveles de luz (alto, 100%; medio, 50%; y bajo, 25% de luz solar) de cinco poblaciones de Capsicum annuum silvestre del noroeste de México. Las características medidas fueron: altura...

Síntesis hidrotérmica del Estanato de Cinc (Zn2SnO4)

OpenAIRE

Solís, José; Naupa, Alexander

2011-01-01

Se sintetizó el estanato de cinc, Zn2SnO4 (ZTO), por el método hidrotérmico empleando una temperatura de 200 °C durante 16 h. El material obtenido fue caracterizado por difracción de rayos X (DRX) y microscopia electrónica de transmisión (MET). El tamaño de grano calculado empleando el software Topas Academic fue de 30 nm. La actividad fotocatalítica del ZTO fue evaluada estudiando la degradación del colorante anaranjado de metilo en solución acuosa bajo iluminación de luz ultravioleta. Los r...

Carcinoma de células escamosas em bovinos, ovinos e eqüinos: estudo de 50 casos no sul do Rio Grande do Sul

OpenAIRE

Adriano Tony Ramos; Diego Mollerke Norte; Fabiana Elias; Cristina Gevehr Fernandes

2007-01-01

O carcinoma de células escamosas (CCE) é um tumor maligno dos queratinócitos. O desenvolvimento desse tipo de tumor está associado a muitos fatores, incluindo a exposição prolongada à luz ultravioleta, falta de pigmento na epiderme, perda de pêlos ou cobertura de pêlos muito esparsa nos locais afetados. Realizou-se um estudo retrospectivo dos casos de carcinoma de células escamosas em animais de produção (bovinos, ovinos e eqüinos) de 1978 a 2002. O material foi obtido nos arquivos do Laborat...

Annual report - Companhia Paulista de Forca e Luz - 1996

International Nuclear Information System (INIS)

1997-01-01

The annual report of 1996 of Companhia Paulista de Forca e Luz - Brazilian electric power company - introduces the next main topics: Brazilian economy and the electric sector; market features and evolution; electric energy tariffs; economic performance; social balance; CPFL shares performance; financial management; investments; human resources; concern for the environment; new business; perspectives for 1997; and financial statements

Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue.

Directory of Open Access Journals (Sweden)

Audrey M Neyrinck

Full Text Available Supra-nutritional doses of curcumin, derived from the spice Curcuma longa, have been proposed as a potential treatment of inflammation and metabolic disorders related to obesity. The aim of the present study was to test whether Curcuma longa extract rich in curcumin and associated with white pepper (Curcuma-P®, at doses compatible with human use, could modulate systemic inflammation in diet-induced obese mice. We questioned the potential relevance of changes in adiposity and gut microbiota in the effect of Curcuma-P® in obesity.Mice were fed either a control diet (CT, a high fat (HF diet or a HF diet containing Curcuma longa extract (0.1 % of curcumin in the HF diet associated with white pepper (0.01 % for four weeks. Curcumin has been usually combined with white pepper, which contain piperine, in order to improve its bioavailability. This combination did not significantly modify body weight gain, glycemia, insulinemia, serum lipids and intestinal inflammatory markers. Tetrahydrocurcumin, but not curcumin accumulated in the subcutaneous adipose tissue. Importantly, the co-supplementation in curcuma extract and white pepper decreased HF-induced pro-inflammatory cytokines expression in the subcutaneous adipose tissue, an effect independent of adiposity, immune cells recruitment, angiogenesis, or modulation of gut bacteria controlling inflammation.These findings support that nutritional doses of Curcuma longa, associated with white pepper, is able to decrease inflammatory cytokines expression in the adipose tissue and this effect could be rather linked to a direct effect of bioactive metabolites reaching the adipose tissue, than from changes in the gut microbiota composition.

Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue.

Science.gov (United States)

Neyrinck, Audrey M; Alligier, Maud; Memvanga, Patrick B; Névraumont, Elodie; Larondelle, Yvan; Préat, Véronique; Cani, Patrice D; Delzenne, Nathalie M

2013-01-01

Supra-nutritional doses of curcumin, derived from the spice Curcuma longa, have been proposed as a potential treatment of inflammation and metabolic disorders related to obesity. The aim of the present study was to test whether Curcuma longa extract rich in curcumin and associated with white pepper (Curcuma-P®), at doses compatible with human use, could modulate systemic inflammation in diet-induced obese mice. We questioned the potential relevance of changes in adiposity and gut microbiota in the effect of Curcuma-P® in obesity. Mice were fed either a control diet (CT), a high fat (HF) diet or a HF diet containing Curcuma longa extract (0.1 % of curcumin in the HF diet) associated with white pepper (0.01 %) for four weeks. Curcumin has been usually combined with white pepper, which contain piperine, in order to improve its bioavailability. This combination did not significantly modify body weight gain, glycemia, insulinemia, serum lipids and intestinal inflammatory markers. Tetrahydrocurcumin, but not curcumin accumulated in the subcutaneous adipose tissue. Importantly, the co-supplementation in curcuma extract and white pepper decreased HF-induced pro-inflammatory cytokines expression in the subcutaneous adipose tissue, an effect independent of adiposity, immune cells recruitment, angiogenesis, or modulation of gut bacteria controlling inflammation. These findings support that nutritional doses of Curcuma longa, associated with white pepper, is able to decrease inflammatory cytokines expression in the adipose tissue and this effect could be rather linked to a direct effect of bioactive metabolites reaching the adipose tissue, than from changes in the gut microbiota composition.

Metabolomic and Lipidomic Analysis of Serum Samples following Curcuma longa Extract Supplementation in High-Fructose and Saturated Fat Fed Rats.

Science.gov (United States)

Tranchida, Fabrice; Shintu, Laetitia; Rakotoniaina, Zo; Tchiakpe, Léopold; Deyris, Valérie; Hiol, Abel; Caldarelli, Stefano

2015-01-01

We explored, using nuclear magnetic resonance (NMR) metabolomics and fatty acids profiling, the effects of a common nutritional complement, Curcuma longa, at a nutritionally relevant dose with human use, administered in conjunction with an unbalanced diet. Indeed, traditional food supplements have been long used to counter metabolic impairments induced by unbalanced diets. Here, rats were fed either a standard diet, a high level of fructose and saturated fatty acid (HFS) diet, a diet common to western countries and that certainly contributes to the epidemic of insulin resistance (IR) syndrome, or a HFS diet with a Curcuma longa extract (1% of curcuminoids in the extract) for ten weeks. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) on the serum NMR profiles and fatty acid composition (determined by GC/MS) showed a clear discrimination between HFS groups and controls. This discrimination involved metabolites such as glucose, amino acids, pyruvate, creatine, phosphocholine/glycerophosphocholine, ketone bodies and glycoproteins as well as an increase of monounsaturated fatty acids (MUFAs) and a decrease of n-6 and n-3 polyunsaturated fatty acids (PUFAs). Although the administration of Curcuma longa did not prevent the observed increase of glucose, triglycerides, cholesterol and insulin levels, discriminating metabolites were observed between groups fed HFS alone or with addition of a Curcuma longa extract, namely some MUFA and n-3 PUFA, glycoproteins, glutamine, and methanol, suggesting that curcuminoids may act respectively on the fatty acid metabolism, the hexosamine biosynthesis pathway and alcohol oxidation. Curcuma longa extract supplementation appears to be beneficial in these metabolic pathways in rats. This metabolomic approach highlights important serum metabolites that could help in understanding further the metabolic mechanisms leading to IR.

Radiación ultravioleta y lesiones melanocíticas. Implicación en prevención y diagnóstico precoz de melanoma.

OpenAIRE

Carrera Álvarez, Cristina

2013-01-01

La radiación ultravioleta (RUV) juega un papel fundamental en el desarrollo de lesiones melanocíticas adquiridas, benignas y malignas, siendo al igual que la presencia de nevus, los principales factores de riesgo para el desarrollo de melanoma. Asimismo, las nuevas clasificaciones moleculares del melanoma han suscitado un creciente interés por el papel etiopatogénico de la RUV. A pesar de los revolucionarios avances en terapéutica, la prevención continúa siendo la pieza clave de la lucha con...

[Screening of anti-lung cancer bioactive compounds from Curcuma longa by target cell extraction and UHPLC/LTQ Orbitrap MS].

Science.gov (United States)

Zhou, Jian-Liang; Wu, Ye-Qing; Tan, Chun-Mei; Zhu, Ming; Ma, Lin-Ke

2016-10-01

A target cell extraction-chemical profiling method based on human alveolar adenocarcinoma cell line (A549 cells) and UHPLC/LTQ Orbitrap MS for screening the anti-lung cancer bioactive compounds from Curcuma longa has been developed in this paper. According to the hypothesis that when cells are incubated together with the extract of Curcuma longa, the potential bioactive compounds in the extract should selectively combine with the cells, then the cell-binding compounds could be separated and analyzed by LC-MS. The bioactive compounds in C. longa are lipophilic components. They intend to be absorbed on the inner wall of cell culture flask when they were incubated with A549 cells, which will produce interference in the blank solution. In this paper, by using cells digestion and multi-step centrifugation and transfer strategy, the interference problem has been solved. Finally, using the developed method, three cell-binding compounds were screened out and were identified as bisdemethoxycurcumin, demethoxycurcumin, and curcumin. These compounds are the main bioactive compounds with anti-lung cancer bioactivity in C. longa. The improved method developed in this paper could avoid the false positive results due to the absorption of lipophilic compounds on the inner wall of cell culture flask, which will to be an effective complementary method for current target cell extraction-chemical profiling technology. Copyright© by the Chinese Pharmaceutical Association.

Anti-glycation and anti-oxidation properties of Capsicum frutescens and Curcuma longa fruits: possible role in prevention of diabetic complication.

Science.gov (United States)

Khan, Ibrar; Ahmad, Haroon; Ahmad, Bashir

2014-09-01

The accumulation of advanced glycationend products (AGE's) in the body, due to the non-enzymatic glycation of proteins is associated with several pathological conditions like aging and diabetes mellitus. Hence a plant having anti-glycation and anti-oxidation potentials may serve as therapeutic agent for diabetic complications and aging. In this study the anti-glycation and anti-oxidation properties of crude methanolic extracts of fruits of Capsicum frutescens and Curcuma longa were investigated. Among the two C. frutescens had more anti-glycation ability with a minimum inhibitory concentration (MIC50) of 90βg/mLas compared to 324βg/mL MIC50 of C. longa. Curcuma longa had the more anti-oxidation potential i.e. 35.01, 30.83 and 28.08% at 0.5mg, 0.25mg and 0.125mg respectively.

RUPTURA DE LA DORMICIÓN Y EXIGENCIAS DE LUZ PARA LA GERMINACIÓN DE SEMILLAS DE Juglans nigra

Directory of Open Access Journals (Sweden)

P. FLORES

2017-12-01

Full Text Available Se evaluaron métodos para superar la dormición y determinar las necesidades de luz en la germinación de Juglans nigra. Para superar la latencia y dureza del endocarpio se realizó Estratificación en caliente (T1, Inmersión en ácido giberélico (T2 y Estratifi cación en frío húmedo (T3. Para la necesidad de luz se evaluó alternancia de oscuridad/luz y oscuridad permanente. Se analizó el Porcentaje Germinación (% de G, Índice Velocidad de Germinación (IVG, Tiempo Medio Germinación Máxima (TMG, % Plántulas Normales, % Semillas sin germinar, Peso Seco Medio de plántulas (PSM y el Índice de Germinación Relativo a la luz (GRL. En T1 no hubo germinación y en T2 irrelevante. T3 produjo diferencias altamente significativas en todas las variables analizadas, siendo el período de 4 meses de estratifi cación el mejor para romper la dormición. Al no ser la luz un factor determinante en la germinación, esta especie se clasifi caría como fotoblástica neutra.

Effects of Curcuma longa extracts on mortality and fecundity of Bactrocera zonata (Diptera: Tephritidae Efeitos dos extratos de Curcuma longa sobre mortalidade e fecundidade de Bactrocera zonata (Diptera: Tephritidae

Directory of Open Access Journals (Sweden)

Abdul Rauf Siddiqi

2011-12-01

Full Text Available The peach fruit fly, Bactrocera zonata, is a significant pest of fruit and vegetable crops in South East Asia and Pacific region. Ccontrol strategies of fruit flies, relying chiefly on insecticides, have serious environmental consequences, disturbing the agro-ecosystem as well as eliminating natural enemies. This study was oriented at exploring the potential of turmeric, Curcuma longa, extracts to control the peach fruit fly. Freshly emerged female adults of Bactrocera zonata were continuously fed for 16 days on diet containing 1000, 500 and 250 ppm of acetone extract of Curcuma longa separately in laboratory cages. The extract caused 85.00, 66.67 and 56.67 percent mortality at 1000, 500 and 250 ppm respectively. The surviving females were mated and allowed to reproduce on clean guava fruits in separate cages. The inhibition in pupal progeny was 67.90, 60.74 and 51.96 percent in the flies fed on 1000, 500 and 250 ppm, the inhibition observed in adult progeny was 84.68, 79.03 and 67.74 percent, respectively.A mosca do pêssego, Bactrocera zonata, é uma importante praga das frutas e produtos hortícolas no Sudeste Asiático e Pacífico. As estratégias de controle de moscas-das-frutas, que se baseia principalmente no uso de inseticidas, têm consequências ambientais graves, perturbando o agroecossistema, bem como eliminando os inimigos naturais. Este estudo foi orientado a explorar as potencialidades dos extratos de açafrão Curcuma longa para controle de B. zonata. Após a emergência, adultos de fêmeas de B. zonata foram continuamente alimentados, durante 16 dias, com dieta contendo 1000, 500 e 250 ppm de extrato acetônico de C. longa separadamente em gaiolas no laboratório. O extrato causou 85,00, 66,67 e 56,67 % de mortalidade em 1000, 500 e 250 ppm, respectivamente. As fêmeas foram acasaladas e postas para ovipositar separadamente em goiabas dentro das gaiolas. A inibição na progênie pupal foi 67,90, 60,74 e 51,96 % nos insetos

La radiación ultravioleta en el docente de Educación Física: Prevención de Riesgos Laborales

OpenAIRE

Rizo Agüera, José; Bernal Valero, Ángel; Hernández García, Ester

2008-01-01

Los docentes de Educación Física representan un grupo de población que se expone crónicamente a la radiación solar. “La importancia de la radiación ultravioleta (RUV) en la inducción de cáncer cutáneo fue demostrada directamente en 1959 por Blum” (Serra y Tribó, 1994, p. 329). Existen pocas investigaciones descriptivas del cuidado de la piel de los educadores físicos. El presente artículo tiene por objeto la reflexión de los riesgos que de la exposición solar se derivan en la labor docente...

Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line

Science.gov (United States)

Kurapati, Kesava Rao V.; Samikkannu, Thangavel; Kadiyala, Dakshayani B.; Zainulabedin, Saiyed M.; Gandhi, Nimisha; Sathaye, Sadhana S.; Indap, Manohar A.; Boukli, Nawal; Rodriguez, Jose W.; Nair, Madhavan P.N.

2015-01-01

Background Many plant-derived products exhibit potent chemopreventive activity against animal tumor models as well as rodent and human cancer cell lines. They have low side effects and toxicity and presumably modulate the factors that are critical for cell proliferation, differentiation, senescence and apoptosis. The present study investigates the effects of some medicinal plant extracts from generally recognized as safe plants that may be useful in the prevention and treatment of cancer. Methods Clonogenic assays using logarithmically-growing cells were performed to test the effect. The cytotoxic effects of Curcuma longa and Zingiber officinale were studied using sulforhodamine B assay, tetrazolium dye assay, colony morphology and microscopic analysis. Results Out of the 13 lyophilized plant-derived extracts evaluated for growth-inhibitory effects on the PC-3M prostate cancer cell line, two extracts derived from C. longa and Z. officinale showed significant inhibitory effects on colony-forming ability. The individual and augmentative effects of these two extracts were tested for their narrow range effective lower concentration on PC-3M in clonogenic assays. At relatively lower concentrations, C. longa showed significant inhibition of colony formation in clonogenic assays; whereas at same concentrations Z. officinale showed only moderate inhibitory effects. However, when both the agents were tested together at the same concentrations, the combined effects were much more significant than their individual ones. On normal prostate epithelial cells both C. longa and Z. officinale had similar effects but at a lower magnitude. These observations were confirmed by several cytotoxicity assays involving the morphological appearance of the colonies, microscopic observations, per cent inhibition in comparison to control by sulforhodamine B and tetrazolium dye assay. Conclusions From these observations, it was concluded that the combined effects of C. longa and Z. officinale

Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp

Science.gov (United States)

Ichthyophthirius multifiliis (Ich) is a ciliated parasite that elicits great economic losses in aquaculture. In the present study, a polyphenol compound, curcumin, was obtained from the rhizome of Curcuma longa by bioassay-guided isolation based on the efficacy of anti-Ich theronts. Anti-Ich efficac...

Gamma ionization of Phagicola longa (Trematoda:Heterophyidae) in Mugilidae (pisces) in Sao Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Antunes, S.A.; Wiendl, F.M.; Almeida Dias, E.R.; Arthur, V.; Daniotti, C. (Sao Paulo Univ., SP (Brazil))

The mullet (Mugilidae) is a fish caught in large quantities in brackish and marine waters of the southern Brazilian coast, which in consequence of its raw consumption as ''sashimi'', a typical Japanese dish, has led to ten cases of human infection by Phagicola longa in Sao Paulo, Brazil. The mullet acts as a second intermediate host for the parasite, as in human heterophyiasis in the Near and Far East. In order to control these infections under commercial storage conditions and in raw consumption, the radiolysis of P. longa was studied in three mullet species - the silver mullet (Mugil curema), the grey mullet (M. platanus) and the ''paratipema'' (Mugil sp.) -subjected to ionization ranging from 1.0 to 10.0 kGy (2.21 kGy/h). It was observed that 1.0 and 2.0 kGy caused a motility decrease in silver mullet parasites from 100% to 15% and 17%, and that doses of 4.0 and 10.0 kGy caused metacercaria inviability. The parasite motility decreased in the grey mullet treated with doses of 2.0, 2.5, 3.0 and 3.5 kGy, from 56% to 31%, 9%, 18% and 5%, respectively, 4.0 kGy tending to be the control dose for P. Longa. This dose also controls other metacercaria found in the ''parati-pema'', without changing the odor, color or appearance of the treated mullet. (author).

Gamma ionization of Phagicola longa (Trematoda:Heterophyidae) in Mugilidae (pisces) in Sao Paulo, Brazil

International Nuclear Information System (INIS)

Antunes, S.A.; Wiendl, F.M.; Almeida Dias, E.R.; Arthur, V.; Daniotti, C.

1993-01-01

The mullet (Mugilidae) is a fish caught in large quantities in brackish and marine waters of the southern Brazilian coast, which in consequence of its raw consumption as ''sashimi'', a typical Japanese dish, has led to ten cases of human infection by Phagicola longa in Sao Paulo, Brazil. The mullet acts as a second intermediate host for the parasite, as in human heterophyiasis in the Near and Far East. In order to control these infections under commercial storage conditions and in raw consumption, the radiolysis of P. longa was studied in three mullet species - the silver mullet (Mugil curema), the grey mullet (M. platanus) and the ''paratipema'' (Mugil sp.) -subjected to ionization ranging from 1.0 to 10.0 kGy (2.21 kGy/h). It was observed that 1.0 and 2.0 kGy caused a motility decrease in silver mullet parasites from 100% to 15% and 17%, and that doses of 4.0 and 10.0 kGy caused metacercaria inviability. The parasite motility decreased in the grey mullet treated with doses of 2.0, 2.5, 3.0 and 3.5 kGy, from 56% to 31%, 9%, 18% and 5%, respectively, 4.0 kGy tending to be the control dose for P. Longa. This dose also controls other metacercaria found in the ''parati-pema'', without changing the odor, color or appearance of the treated mullet. (author)

Atenuação da intensidade de luz e profundidade de polimerização de resinas compostas

OpenAIRE

Werlang, Jean Felipe Garlet; Dalfovo, Ricardo João; Neiva, Ivana Froede; Obici, Andresa Carla

2016-01-01

Objetivo: Avaliar a atenuação da luz através de diferentes espessuras de resina composta e a profundidade de polimerização. Materiais e Métodos: Foram utilizadas as resinas Opallis e Llis de esmalte (E) e de dentina (D), na cor A3. Para atenuação da luz foram empregadas matrizes metálicas (6,0mm de diâmetro e espessuras de 0,5, 1,0, 1,5 e 2,0mm), as quais foram posicionadas na janela de leitura do radiômetro e a intensidade de luz medida antes e após a interposição do material. A profundidade...

Estudio espectroscópico de la radiación electromagnética ultravioleta, visible e infrarroja cercana sobre la obra pictórica.

OpenAIRE

D'ANTONI, PABLO LUIS

2013-01-01

La Tesis "Estudio Espectroscópico de la Radiación Electromagnética, Ultravioleta Visible e Infrarroja cercana sobre la Obra Pictórica" de Pablo D'Antoni desarrolla un método no invasivo para caracterizar, medir y predecir daños a los pigmentos y aglutinantes en obras pictóricas, probablemente por la radiación electromagnética (REM). Usando 3 formas de Espectroscopia: 1) Irradiancia, 2) FORS(Espectroscopía de Reflectancia (y Absorbancia) con Fibra Optica, se analizan los efectos producidos por...

Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

DEFF Research Database (Denmark)

Dao, Trong Tuan; Won, Ho Keun; Kim, Eun Hee

2012-01-01

The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong in...

Treatment of Bothrops alternatus envenomation by Curcuma longa and Calendula officinalis extracts and ar-turmerone Tratamento local do envenenamento por Bothrops alternatus com extrato de Curcuma longa e Calendula officinalis e ar-turmerone

Directory of Open Access Journals (Sweden)

M.M. Melo

2005-02-01

Full Text Available It was investigated the efficiency of two extracts of plants and one fraction of their properties against the local effects of bothropic envenomation. Bothrops alternatus venom (1.25µg diluted in 100µl of sterile saline solution was inoculated (intradermally into the shaved dorsal back skin of 30 New Zealand rabbits. The animals were divided in six groups receiving the following treatments: group I: subcutaneous application of Curcuma longa extract (1.0ml; group II: topic treatment of Curcuma longa hydroalcoholic extract (1.0ml; group III: topic application of ar-turmerone in vaseline (1.0g; group IV: topic application of Curcuma longa methanolic extract (1.0ml; group V: topic application of Calendula officinalis ointment (1.0g; group VI: topic application of saline (1.0ml. These treatments were done at 30 minutes, and at 2, 4, 24 and 72 hours after venom inoculation. Intensity of local edema, hemorrhagic halo and necrosis were evaluated until 168h after that. Additionally, seven days after the Bothrops venom inoculation, blood was collected from heart with and without EDTA (10% for hemogram and biochemical parameters (total protein, blood urea nitrogen, creatinine, and fibrinogen and all the animals were anesthetized, sacrificed by ether inhalation and submitted to necropsy. Fragments of tissues were taken for histopathological evaluation. The most efficient treatment for inhibition of edema, necrosis and local hemorrhage after Bothrops alternatus venom was the topic application of ar-turmerone.Investigou-se a eficácia do extrato de plantas no tratamento local do envenenamento botrópico. Veneno de serpentes Bothrops alternatus (1,25µg diluído em 100µl de solução salina estéril foi inoculado (via intradérmica entre as escápulas de 30 coelhos. Os animais foram divididos em seis grupos (tratamentos: grupo I: tratamento subcutâneo com extrato de Curcuma longa; grupo II: tratamento tópico com extrato hidroalcoólico de Curcuma longa

The process of implantation of the 'Programa Luz para Todos' in Ubatuba, Sao Paulo; O processo de implantacao do Programa Luz para Todos em Ubatuba, Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Fernando Selles; Yoshino, Shinji [Furnas Centrais Eletricas, Sao Paulo, SP (Brazil)], Emails: fselles@uol.com.br, shinji.yoshino@uol.com.br; Ribeiro, Tina Bimestre Selles [Universidade de Sao Paulo (IEE-USP), SP (Brazil). Inst. de Eletrotecnica e Energia], E-mail: tina@iee.usp.br

2009-07-01

The municipality of Ubatuba is covered by a rain forest Mata Atlantica preserved in most of the territory. There are many communities that demand electricity in this area, including traditional communities like culture named 'caicara' and the remnants of slaves from Brazil colony named 'quilombos'. They are all very poor and are involved by the interest of environmental agencies. The process of rural electrification in Ubatuba, through the 'Programa Luz para Todos' found difficult to overcome issues of regularization of habitations particularly environmental issues. This work shows that solutions were found through negotiation between the parts, intermediated by an officer known as 'Agente Luz para Todos'. It shows also that without the participation of this agent would have been very difficult exceed some of the barriers. (author)

Production of Gentisyl Alcohol from Phoma herbarum Endophytic in Curcuma longa L. and Its Antagonistic Activity Towards Leaf Spot Pathogen Colletotrichum gloeosporioides.

Science.gov (United States)

Gupta, Suruchi; Kaul, Sanjana; Singh, Baljinder; Vishwakarma, Ram A; Dhar, Manoj K

2016-11-01

Endophytes from medicinal plants represent a potential source of bioactive compounds. During the present investigation, fungal endophytes were isolated from turmeric (Curcuma longa), an important medicinal plant. A total of 207 endophytic fungal isolates were obtained from the rhizome of C. longa L. They were grouped into seven genera based on morphological and molecular data. The fungal endophytes of C. longa were evaluated for antifungal activity against Colletotrichum gloeosporioides, the causal organism of leaf spot of turmeric. The disease is a major cause for economic loss in turmeric cultivation. Endophytic Phoma herbarum showed significant activity against C. gloeosporioides and was therefore selected for further studies. A compound gentisyl alcohol was isolated from P. herbarum which showed effective antagonism against C. gloeosporioides. The organism could therefore be used as a biocontrol agent against C. gloeosporioides.

Isolation and characterization of bacterial endophytes of Curcuma longa L.

OpenAIRE

Kumar, Ajay; Singh, Ritu; Yadav, Akhilesh; Giri, D. D.; Singh, P. K.; Pandey, Kapil D.

2016-01-01

Fourteen endophytic bacterial isolates were isolated from the rhizome of Curcuma longa L. were characterized on the basis of morphology, biochemical characteristics and 16S rRNA gene sequence analysis. The isolates were identified to six strains namely Bacillus cereus (ECL1), Bacillus thuringiensis (ECL2), Bacillus sp. (ECL3), Bacillus pumilis (ECL4), Pseudomonas putida (ECL5), and Clavibacter michiganensis (ECL6). All the strains produced IAA and solubilized phosphate and only two strains pr...

Curcumin longa extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release.

Science.gov (United States)

Ahn, Min Young; Hwang, Jung Seok; Lee, Su Bi; Ham, Sun Ah; Hur, Jinwoo; Kim, Jun Tae; Seo, Han Geuk

2017-01-01

High mobility group box 1 (HMGB1) is a well-known damage-related alarmin that participates in cellular inflammatory responses. However, the mechanisms leading to HMGB1 release in inflammatory conditions and the therapeutic agents that could prevent it remain poorly understood. This study attempted to examine whether the Curcumin longa herb, which is known to have anti-inflammatory property, can modulate cellular inflammatory responses by regulating HMGB1 release. The murine macrophage RAW264.7 cells were treated with lipopolysaccharide (LPS) and/or a C. longa extract-loaded nanoemulsion (CLEN). The levels of released HMGB1, nitric oxide (NO) production, inducible NO synthase (iNOS) expression, and phosphorylation of mitogen-activated protein kinases were analyzed in RAW264.7 macrophages. The effects of CLEN on survival of endotoxemic model mice, circulating HMGB1 levels, and tissue iNOS expression were also evaluated. We have shown that a nanoemulsion loaded with an extract from the C. longa rhizome regulates cellular inflammatory responses and LPS-induced systemic inflammation by suppressing the release of HMGB1 by macrophages. First, treatment of RAW264.7 macrophages with the nanoemulsion significantly attenuated their LPS-induced release of HMGB1: this effect was mediated by inhibiting c-Jun N-terminal kinase activation, which in turn suppressed the NO production and iNOS expression of the cells. The nanoemulsion did not affect LPS-induced p38 or extracellular signal-regulated kinase activation. Second, intraperitoneal administration of the nanoemulsion improved the survival rate of LPS-injected endotoxemic mice. This associated with marked reductions in circulating HMGB1 levels and tissue iNOS expression. The present study shows for the first time the mechanism by which C. longa ameliorates sepsis, namely, by suppressing NO signaling and thereby inhibiting the release of the proinflammatory cytokine HMGB1. These observations suggest that identification of

Curcumin longa extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release

Directory of Open Access Journals (Sweden)

Min Young Ahn

2017-09-01

Full Text Available Background High mobility group box 1 (HMGB1 is a well-known damage-related alarmin that participates in cellular inflammatory responses. However, the mechanisms leading to HMGB1 release in inflammatory conditions and the therapeutic agents that could prevent it remain poorly understood. This study attempted to examine whether the Curcumin longa herb, which is known to have anti-inflammatory property, can modulate cellular inflammatory responses by regulating HMGB1 release. Methods The murine macrophage RAW264.7 cells were treated with lipopolysaccharide (LPS and/or a C. longa extract-loaded nanoemulsion (CLEN. The levels of released HMGB1, nitric oxide (NO production, inducible NO synthase (iNOS expression, and phosphorylation of mitogen-activated protein kinases were analyzed in RAW264.7 macrophages. The effects of CLEN on survival of endotoxemic model mice, circulating HMGB1 levels, and tissue iNOS expression were also evaluated. Results We have shown that a nanoemulsion loaded with an extract from the C. longa rhizome regulates cellular inflammatory responses and LPS-induced systemic inflammation by suppressing the release of HMGB1 by macrophages. First, treatment of RAW264.7 macrophages with the nanoemulsion significantly attenuated their LPS-induced release of HMGB1: this effect was mediated by inhibiting c-Jun N-terminal kinase activation, which in turn suppressed the NO production and iNOS expression of the cells. The nanoemulsion did not affect LPS-induced p38 or extracellular signal-regulated kinase activation. Second, intraperitoneal administration of the nanoemulsion improved the survival rate of LPS-injected endotoxemic mice. This associated with marked reductions in circulating HMGB1 levels and tissue iNOS expression. Discussion The present study shows for the first time the mechanism by which C. longa ameliorates sepsis, namely, by suppressing NO signaling and thereby inhibiting the release of the proinflammatory cytokine HMGB1

Green synthesis of ZnO nanoparticles via complex formation by using Curcuma longa extract

Energy Technology Data Exchange (ETDEWEB)

Fatimah, Is, E-mail: isfatimah@uii.ac.id; Yudha, Septian P.; Mutiara, Nur Afisa Lintang [Chemistry Department, Islamic University of Indonesia Kampus Terpadu UII, Jl. Kaliurang Km 14, Sleman, Yogyakarta (Indonesia)

2016-02-08

Synthesis of ZnO nanoparticles(NPs) were conducted via Zn(II) complex formation by using Curcuma longa extract as template. Curcuma longa extract has the ability to form zinc ions complex with curcumin as ligating agent. Study on synthesis was conducted by monitoring thermal degradation of the material. Successful formation of zinc oxide nanoparticles was confirmed by employing x-ray diffraction, surface area analysis and transmission electron microscopy(TEM) studies. From the XRD analysis it is denoted that ZnO in hexagonal wurtzite phase was formed and particle size was varied as varied temperature. The data are also confirmed by TEM analysis which shows the particle sie at the range 20-80nm. The NPs exhibited excelent photocatalytic activity for methylene blue degradation and also significant antibacterial activity for Eschericia coli. The activity in methylene blue degradation was also confirmed from fast chemical oxygen demand (COD) reduction.

Green synthesis of ZnO nanoparticles via complex formation by using Curcuma longa extract

International Nuclear Information System (INIS)

Fatimah, Is; Yudha, Septian P.; Mutiara, Nur Afisa Lintang

2016-01-01

Synthesis of ZnO nanoparticles(NPs) were conducted via Zn(II) complex formation by using Curcuma longa extract as template. Curcuma longa extract has the ability to form zinc ions complex with curcumin as ligating agent. Study on synthesis was conducted by monitoring thermal degradation of the material. Successful formation of zinc oxide nanoparticles was confirmed by employing x-ray diffraction, surface area analysis and transmission electron microscopy(TEM) studies. From the XRD analysis it is denoted that ZnO in hexagonal wurtzite phase was formed and particle size was varied as varied temperature. The data are also confirmed by TEM analysis which shows the particle sie at the range 20-80nm. The NPs exhibited excelent photocatalytic activity for methylene blue degradation and also significant antibacterial activity for Eschericia coli. The activity in methylene blue degradation was also confirmed from fast chemical oxygen demand (COD) reduction

Green synthesis of ZnO nanoparticles via complex formation by using Curcuma longa extract

Science.gov (United States)

Fatimah, Is; Yudha, Septian P.; Mutiara, Nur Afisa Lintang

2016-02-01

Synthesis of ZnO nanoparticles(NPs) were conducted via Zn(II) complex formation by using Curcuma longa extract as template. Curcuma longa extract has the ability to form zinc ions complex with curcumin as ligating agent. Study on synthesis was conducted by monitoring thermal degradation of the material. Successful formation of zinc oxide nanoparticles was confirmed by employing x-ray diffraction, surface area analysis and transmission electron microscopy(TEM) studies. From the XRD analysis it is denoted that ZnO in hexagonal wurtzite phase was formed and particle size was varied as varied temperature. The data are also confirmed by TEM analysis which shows the particle sie at the range 20-80nm. The NPs exhibited excelent photocatalytic activity for methylene blue degradation and also significant antibacterial activity for Eschericia coli. The activity in methylene blue degradation was also confirmed from fast chemical oxygen demand (COD) reduction.

The effect of hydro-ethanolic extract of Curcuma longa rhizome and curcumin on total and differential WBC and serum oxidant, antioxidant biomarkers in rat model of asthma

OpenAIRE

Farzaneh Shakeri; Mohammad Soukhtanloo; Mohammad Hossein Boskabady

2017-01-01

Objective(s): The effects of Curcuma longa (C. longa) and curcumin on total and differential WBC count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. Materials and Methods: Total and differential WBC count in the blood, NO2, NO3, MDA, SOD, CAT and thiol levels in serum were examined in control, asthma, Asthmatic rats treated with C. longa (0.75, 1.50, and 3.00 mg/ml), curcumin (0.15, 0.30, and 0.60 mg/ml), and dexamethasone (1.25 ?g/ml) rats. Results: Total and mo...

Annual report - Companhia Paulista de Forca e Luz - 1998

International Nuclear Information System (INIS)

1999-03-01

The annual report of 1998 of Companhia Paulista de Forca e Luz - Brazilian electric power company - introduces the next main topics: management's report; economic scenario; the new brazilian energy sector; market strategy; business opportunities - electricity tariffs, economic and financial performance; financial aspects - domestic market, international market, capital subscriptions; investments; performance of CPFL; investors' relations, human resources; contribution to the community - personnel, cultural events, social contribution; environmental concern; and financial statements

Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice.

Science.gov (United States)

Sengupta, Mahuya; Sharma, Gauri Dutta; Chakraborty, Biswajit

2011-06-01

To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl4 intoxicated Swiss albino mice. First group of mice (n=5) received CCl4 treatment at a dose of 0.5 mL/kg bw (i.p.) for 7 days. Second group was fed orally the aqueous extract of turmeric at a dose of 50 mg/kg bw for 15 days. The third group was given both the turmeric extract (for 15 days, orally) and CCl4 (for last 7 days, i.p.). The fourth group was kept as a control. To study the liver function, the transaminase enzymes (SGOT and SGPT) and bilirubin level were measured in the serum of respective groups. For assaying the immunotherapeutic action of Curcuma longa (C. longa), non specific host response parameters like morphological alteration, phagocytosis, nitric oxide release, myeloperoxidase release and intracellular killing capacity of peritoneal macrophages were studied from the respective groups. The result of present study suggested that CCl4 administration increased the level of SGOT and SGPT and bilirubin level in serum. However, the aqueous extract of turmeric reduced the level of SGOT, SGPT and bilirubin in CCl4 intoxicated mice. Apart from damaging the liver system, CCl4 also reduced non specific host response parameters like morphological alteration, phagocytosis, nitric oxide release, myeloperoxidase release and intracellular killing capacity of peritoneal macrophages. Administration of aqueous extract of C. longa offered significant protection from these damaging actions of CCl4 on the non specific host response in the peritoneal macrophages of CCl4 intoxicated mice. In conclusion, the present study suggests that C. longa has immunotherapeutic properties along with its ability to ameliorate hepatotoxicity.

Gamma ionization of Phagicola longa (Trematoda:Heterophyidae) in Mugilidae (pisces) in São Paulo, Brazil

Science.gov (United States)

Antunes, S. A.; Wiendl, F. M.; Almeida Dias, E. R.; Arthur, V.; Daniotti, C.

1993-07-01

The mullet (Mugilidae) is a fish caught in large quantities in brackish and marine waters of the southern Brazilian coast, which in consequence of its raw consumption as "sashimi", a typical Japanese dish, has led to ten cases of human infection by Phagicola longa in São Paulo, Brazil. The mullet acts as a second intermediate host for the parasite, as in human heterophysiasis in the Near and Far East. In order to control these infections under commercial storage conditions and in raw consumption, the radiolysis of P. longa was studied in three mullet species-the silver mullet ( Mugil curema), the grey mullet ( M. platanus) and the "paratipema" ( Mugil sp.) - subjected to ionization ranging from 1.0 to 10.0 kGy (2.21 kGy/h). It was observed that 1.0 and 2.0 kGy caused a motility decrease in silver mullet parasites from 100% to 15% and 17%, and that doses of 4.0 and 10.0 kGy caused metacercaria inviability. The parasite motility decreased in the grey mullet treated with doses of 2.0, 2.5, 3.0 and 3.5 kGy, from 56% to 31%, 9%, 18% and 5%, respectively, 4.0 kGy tending to be the control dose for P. longa. This dose also controls other metacercaria found in the "parati-pema", without changing the odor, color or appearance of the treated mullet.

Alexandre Grandazzi, Alba Longa. Histoire d’une légende

OpenAIRE

Richard, Jean-Claude

2012-01-01

Il libro di A. Grandazzi si segnala per le dimensioni e per la portata della ricerca : circa mille pagine, distribuite su due volumi di pari ampiezza, sviluppano, per la prima volta in modo esaustivo, il vessato problema storiografico relativo alla genesi della leggenda romana di Alba Longa. L’autore mostra con chiarezza che le prime scoperte archeologiche sui Colli Albani, risalenti al 1816-1817, riportarono in auge un’antica questione, sentita già in epoca romana : l’esatta localizzazione d...

EVALUACIÓN DE LA ACTIVIDAD ANTIOXIDANTE DE ACEITES ESENCIALES EN EMULSIONES DEGRADADAS POR RADIACIÓN ULTRAVIOLETA

Directory of Open Access Journals (Sweden)

Geovanna Tafur

2008-03-01

Full Text Available En este trabajo se evaluaron las actividades antioxidantes in vitro de los aceites esenciales de Origanum vulgare L., Rosmarinusofficinalis L. y Coriandrum sativum L., en emulsiones de agua en aceite (Ag/Ac y aceite en agua (Ac/Ag, sometidas al deterioro oxidativo por medio de la radiación ultravioleta A-visible (UVAVIS.En la emulsión de Ag/Ac (margarina, el aceite esencial de orégano presentó actividad antioxidante superior a la del cilantro y el romero, e incluso a la de la vitamina E, en concentraciones de 1, 10 y 20 g/kg. Se estableció además, que la acción antioxidante in vitro de los aceitesesenciales de orégano y cilantro aumentaba con su concentración en la margarina.Por último, el aceite esencial de orégano presentó una acción protectora más baja en la emulsión de Ac/Ag.

Dietary Intake of Curcuma longa and Emblica officinalis Increases Life Span in Drosophila melanogaster

Directory of Open Access Journals (Sweden)

Shilpa Rawal

2014-01-01

Full Text Available Intake of food and nutrition plays a major role in affecting aging process and longevity. However, the precise mechanisms underlying the ageing process are still unclear. To this respect, diet has been considered to be a determinant of ageing process. In order to better illustrate this, we used Drosophila melanogaster as a model and fed them orally with different concentrations of two commonly used Indian medicinal plant products, Curcuma longa (rhizome and Emblica officinalis (fruit. The results revealed significant increase in life span of Drosophila flies on exposure to both the plant products, more efficiently by C. Longa than by E. officinalis. In order to understand whether the increase in lifespan was due to high-antioxidant properties of these medicinal plants, we performed enzymatic assays to assess the SOD and catalase activities in case of both treated and control Drosophila flies. Interestingly, the results support the free radical theory of aging as both these plant derivatives show high reactive oxygen species (ROS scavenging activities.

Phototoxic action of light emitting diode in the in vitro viability of Trichophyton rubrum Ação fototóxica do diodo emissor de luz na viabilidade de Trichophyton rubrum in vitro

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José Cláudio Faria Amorim

2012-04-01

Full Text Available BACKGROUND: Trichophyton rubrum is the most common agent of superficial mycosis of the skin and nails causing long lasting infections and high recurrence rates. Current treatment drawbacks involve topical medications not being able to reach the nail bed at therapeutic concentrations, systemic antifungal drugs failing to eradicate the fungus before the nails are renewed, severe side effects and selection of resistant fungal isolates. Photodynamic therapy (PDT has been a promising alternative to conventional treatments. OBJECTIVES: This study evaluated the in vitro effectiveness of toluidine blue O (TBO irradiated by Light emitting diode (LED in the reduction of T. rubrum viability. METHODS: The fungal inoculums' was prepared and exposed to different TBO concentrations and energy densities of Light emitting diode for evaluate the T. rubrum sensibility to PDT and production effect fungicidal after photodynamic treatment. In addition, the profiles of the area and volume of the irradiated fungal suspensions were also investigated. RESULTS: A small reduction, in vitro, of fungal cells was observed after exposition to 100 µM toluidine blue O irradiated by 18 J/cm² Light emitting diode. Fungicidal effect occurred after 25 µM toluidine blue O irradiation by Light emitting diode with energy density of 72 J/cm². The analysis showed that the area and volume irradiated by the Light emitting diode were 52.2 mm² and 413.70 mm³, respectively. CONCLUSION: The results allowed to conclude that Photodynamic therapy using Light emitting diode under these experimental conditions is a possible alternative approach to inhibit in vitro T. rubrum and may be a promising new treatment for dermatophytosis caused by this fungus.FUNDAMENTOS: Trichophyton rubrum é o agente mais comum das micoses superficiais de pele e unhas causando infecções de longa duração e altas taxas de recidiva. As desvantagens do tratamento atual envolvem medicações tópicas as quais n

Isolation and spectroscopic studies of curcumin from Philippine Curcuma longa L

International Nuclear Information System (INIS)

Torres, Rosalinda C.; Bonifacio, Teresita S.; Herrera, Celia L.; Lanto, Eduardo A.

1998-01-01

Curcumin, the yellow coloring matter was isolated from the rhizomes of Philippine Curcuma longa L. (turmeric) by Soxhlet extraction with toluene followed by concentration and slow crystallization. The isolated curcumin was then subjected to chromatographic and spectroscopic studies with the Merck curcumin standard. The infra red and UV-vis spectra of both compounds were found to be almost identical indicating a high purity of the isolate. The % yield obtained was 2-3%. (Author)

Antidermatophytic Properties of Ar-Turmerone, Turmeric Oil, and Curcuma longa Preparations

OpenAIRE

Jankasem, Mukda; Wuthi-udomlert, Mansuang; Gritsanapan, Wandee

2013-01-01

Curcuma longa L. or turmeric of the family Zingiberaceae is widely used in Thai traditional medicines for the treatment of rash, itching, tinea, and ringworm. Previous studies on turmeric oil reported effective antifungal activity against dermatophytes, a group of fungi that causes skin diseases. In this study, turmeric creams containing 6 and 10%?w/w turmeric oil were prepared and tested against clinical strains of dermatophytes using broth dilution technique. Minimum fungicidal concentratio...

PHYTOPHARMACEUTICAL POTENTIAL AND MICROSCOPIC ANALYSIS OF RHIZOMES OF CURCUMA LONGA AND ZINGIBER OFFICINALE (ZINGIBERACEAE

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Abdullahi Alanamu ABDULRAHAMAN

2015-12-01

Full Text Available Turmeric and ginger are spices derived from the rhizomes of Curcuma longa and Zingiber officinale respectively. The rhizomes of C. longa and Z. officinale were extracted in hexane, ethyl acetate, methanol and water. Phytochemical screening was carried out on each of the extracts. Proximate analysis to determine the extractive values, moisture content, total ash, crude fibre, acid insoluble ash and water soluble ash were carried out on the rhizomes of fresh and dried turmeric and ginger. The rhizomes of C. longa revealed alcohol extractive value 22.79%, water extractive value 26.44%, moisture content 11.56 ± 0.04%, total ash 13.24±0.03%, crude fiber 6.40±0.20%, acid insoluble ash 1.02±0.02% and water soluble ash 4.32±0.07%. Extractive values for ginger were recorded as alcohol 2.7% and water 2.1%, fresh and dried ginger rhizomes afforded, moisture content 72.63 ±0.09%, 10.03±0.09%, total ash 2.50 ±0.06%, 7.30±0.10%, acid insoluble ash 0.57±0.03%, 2.03±0.09%, and water soluble ash 1.23±0.03%, 3.87±0.09% respectively. Observations on the microscopic studies of the fresh rhizomes of turmeric and ginger revealed possession of oil duct and spiral xylem vessels. Similarly phytomorphology of the powdered rhizomes of ginger and turmeric revealed the presence of tracheid and compartment of vessels. Presence of similar anatomical features in both the fresh and ground samples confirmed the authenticity or adulterous of the powdered samples.

Proteção à radiação ultravioleta: recursos disponíveis na atualidade em fotoproteção Ultraviolet radiation protection: current available resources in photoprotection

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Tatiana Santana Balogh

2011-08-01

Full Text Available A radiação ultravioleta pode provocar danos ao DNA, imunossupressão, alterações químicas e histológicas na epiderme, envelhecimento precoce, cataratas e carcinogênese, dentre outras deteriorações. A fotoproteção previne estes e outros efeitos danosos da radiação ultravioleta. Protetores solares, vestimentas, acessórios adequados e exposição segura ao sol são ferramentas essenciais da fotoproteção. Neste artigo, são apresentadas e discutidas as principais formas de fotoproteção, incluindo os protetores solares com filtros inorgânicos e orgânicos, a avaliação da eficácia dos mesmos e atualizações envolvendo o temaUltraviolet radiation can damage the DNA, cause immunosuppression, chemical and histological alterations in the epidermis, early photoaging, cataracts and carcinogenesis, among others. Photoprotection prevents these and other harmful effects of ultraviolet radiation. Sunscreens, protective clothing, proper accessories and safe sun exposure are essential photoprotection tools. The main forms of photoprotection are presented and discussed in this article, including sunscreens containing organic and inorganic filters, the assessment of their efficacy and current developments on the topic

The distribution systems of the Luz y Fuerza del Centro; Sistemas de distribucion en Luz y Fuerza del Centro

Energy Technology Data Exchange (ETDEWEB)

Espinosa y Lara, Roberto [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

1997-12-31

In this document are described the distribution systems that have been utilized in Mexico, to satisfy the electric energy demand. Mention is made of the areas of influence these systems have, its structure, the electric infrastructure that Luz y Fuerza del Centro has to satisfy the demand and in this way be in position of planning the distribution networks. As in other activities the aspects related to the protection of the environment exert a growing influence on the development of the energy sector, for this reason three themes are mentioned to which special attention must be paid. A table is shown with the per capita consumption, another one with the number of transformers and its capacity. Also the underground networks in operation and under construction are shown and a flow diagram of the distribution system planning [Espanol] En este documento se describen los sistemas de distribucion que se han realizado en Mexico, para satisfacer la demanda electrica, se mencionan las areas de influencia que tienen estos sistemas, su estructuracion, la infraestructura electrica con la que cuenta Luz y Fuerza del Centro para satisfacer las demandas y asi poder planear las redes de distribucion. Como en otras actividades, los aspectos relacionados con el cuidado del ambiente ejercen una influencia creciente sobre el desenvolvimiento del sector de energia, es por eso que se mencionan tres temas a los que se les debe de poner especial atencion. Se muestra una tabla de consumo per capita, otra del numero de transformadores y su capacidad. Tambien se ilustran las redes subterraneas en operacion y construccion y un flujograma de planeacion del sistema de distribucion

Occurrence of curcuminoids in Curcuma longa : A quality standardization by HPTLC

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M Paramasivam

2008-06-01

Full Text Available A simple high performance thin layer chromatographic (HPTLC method has been developed for the simultaneous determination of the pharmacologically important active Curcuminoids viz. curcumin, demthoxycurcumin and bis-demethoxycurcumin in Curcuma longa L. The assay combines the separation and quantification of the analytes on silica gel 60 GF254 HPTLC plates with visualisation under UV and scanning at 425 nm. Using this technique, the alkaloidal content of different parts of the title plant has been determined.

Effectiveness of composite resin polymerization using light-emitting diodes (LEDs or halogen-based light-curing units Efetividade de polimerização de uma resina composta fotopolimerizada por diodos emissores de luz (LEDs ou luz halógena

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Bianca Micali

2004-09-01

Full Text Available The clinical performance of composite resins is greatly influenced by the quality of the light-curing unit used. The aim of this study was to compare the efficiency of a commercial light-emitting diode (LED with that of a halogen-based light-curing unit by means of dye penetration of a micro hybrid composite resin. The composite resin evaluated was Filtek Z250 (3M Dental. The composite was filled into acrylic moulds that were randomly polymerized for 40 seconds by each of the light-emitting systems: light-emitting diode Ultraled (Dabi Atlante or halogen light Degulux (Degussa Hüls curing units. Immediately after polymerization, each specimen was individually immersed in 1 ml of 2% methylene blue solution at 37°C ± 2°C. After 24 hours, the specimens were rinsed under running distilled water for 1 minute and stored at 37°C ± 2°C at relative humidity for 24 hours. The composite resins were removed from the moulds and individually triturated before being immersed in new test tubes containing 1 ml of absolute alcohol for 24 hours. The solutions were filtered and centrifuged for 3 minutes at 4,000 rpm and the supernatant was used to determine absorbance in a spectrophotometer at 590 nm. To verify the differences between groups polymerized by LED or halogen light t-test was applied. No significant differences were found between composite resins light-cured by LED or halogen light-curing unit (p > 0.05. The commercially LED-based light-curing unit is as effective to polymerize hybrid composite resins as the halogen-based unit.A longevidade clínica das resinas compostas é grandemente influenciada pela qualidade do aparelho fotopolimerizador utilizado. O objetivo deste trabalho foi comparar a eficácia de um aparelho fotopolimerizador de diodos emissores de luz e a de um de luz halógena através do grau de penetração de um corante em uma resina composta micro-híbrida. A resina composta utilizada (Filtek Z250/3M Dental foi inserida em matrizes

Interferência da disponibilidade de luz na resposta à adubação de plantios de enriquecimento com leguminosas arbóreas

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Marco Aurélio de Carvalho Silva

2013-03-01

Full Text Available O objetivo deste trabalho foi avaliar a interferência da disponibilidade de luz na resposta à adubação de plantios de enriquecimento da capoeira com leguminosas arbóreas. As espécies Hymenaea courbaril, Stryphnodendron guianense, Parkia platycephala e Stryphnodendron microstachyum foram plantadas em capoeira, sob três tratamentos de fertilização: adubação orgânica, adubação orgânica acrescida de mineral e ausência de adubação. A disponibilidade de luz condicionou a resposta de P. platycephala e H. courbaril à fertilização. A aleatorização não foi suficiente para garantir condições semelhantes de luz nos plantios de enriquecimento. A variação na quantidade de luz incidente no sub‑bosque compromete a correta avaliação dos tratamentos de fertilização.

Termitarium-Inhabiting Bacillus spp. Enhanced Plant Growth and Bioactive Component in Turmeric (Curcuma longa L.).

Science.gov (United States)

Chauhan, Ankit Kumar; Maheshwari, Dinesh Kumar; Dheeman, Shrivardhan; Bajpai, Vivek K

2017-02-01

Curcumin (diferuloyl methane) is the main bioactive component of turmeric (Curcuma longa L.) having remarkable multipotent medicinal and therapeutic applications. Two Bacilli isolated from termitarium soil and identified as Bacillus endophyticus TSH42 and Bacillus cereus TSH77 were used for bacterization of rhizome for raising C. longa ver. suguna for growth and enhancement. Both the strains showed remarkable PGP activities and also chemotactic in nature with high chemotactic index. Turmeric plants bacterized with strains B. endophyticus TSH42 and B. cereus TSH77 individually and in combination increased plant growth and turmeric production up to 18% in field trial in comparison to non-bacterized plants. High-performance liquid chromatography analysis was performed to determine the content of curcumin, which showed concentration of curcumin in un-inoculated turmeric as 3.66 g which increased by 13.6% (4.16 g) when combination of TSH42 and TSH77 was used.

Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity

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Ana Claudia F. Amaral

2014-01-01

Full Text Available Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory concentration (MIC. In addition, cellular alterations of treated promastigotes were investigated under transmission and scanning electron microscopies. LipoRHIC and LipoRHIWC presented lower MIC, 5.5 and 12.5 μg/mL, when compared to nonencapsulated fractions (125 and 250 μg/mL, respectively, and to ar-turmerone (50 μg/mL. Parasite growth inhibition was demonstrated to be dose-dependent. Important morphological changes as rounded body and presence of several roles on plasmatic membrane could be seen on L. amazonensis promastigotes after treatment with subinhibitory concentration (2.75 μg/mL of the most active LipoRHIC. In that sense, the hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation (LipoRHIC could represent good strategy for the development of new antileishmanial agent.

Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity

Science.gov (United States)

Amaral, Ana Claudia F.; Gomes, Luciana A.; Silva, Jefferson Rocha de A.; Ferreira, José Luiz P.; Ramos, Aline de S.; Rosa, Maria do Socorro S.; Vermelho, Alane B.; Rodrigues, Igor A.

2014-01-01

Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory concentration (MIC). In addition, cellular alterations of treated promastigotes were investigated under transmission and scanning electron microscopies. LipoRHIC and LipoRHIWC presented lower MIC, 5.5 and 12.5 μg/mL, when compared to nonencapsulated fractions (125 and 250 μg/mL), respectively, and to ar-turmerone (50 μg/mL). Parasite growth inhibition was demonstrated to be dose-dependent. Important morphological changes as rounded body and presence of several roles on plasmatic membrane could be seen on L. amazonensis promastigotes after treatment with subinhibitory concentration (2.75 μg/mL) of the most active LipoRHIC. In that sense, the hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation (LipoRHIC) could represent good strategy for the development of new antileishmanial agent. PMID:25045693

Vertical distribution, feeding and vulnerability to tactile predation in Metridia longa (Copepoda, Calanoida)

KAUST Repository

Vestheim, Hege

2013-12-01

We assessed the vertical distribution and feeding of the calanoid copepod Metridia longa in the Oslofjord, Norway during winter and spring 2006. Adult females of Metridia longa inhabited the whole 200 m deep-water column. Their distribution was shallower at night than during the day. Enumeration of egested faecal pellets suggested that feeding activity was greater at night than during the day and that more pellets were produced by individuals collected at shallow depths vs. by individuals found deeper. There was no pronounced difference between months in feeding activity. Although the hypothesis is that they prey on Calanus eggs and nauplii, scanning of Metridia faecal pellets by PCR using Calanus-specific primers did not confirm the presence of any Calanus prey DNA. Most pellets had a greenish colour, implying herbivorous feeding. Feeding is related to swimming, and the actively swimming Metridia would presumably be vulnerable to tactile invertebrate predators. However, predation experiments where the carnivorous copepod Pareuchaeta norvegica was offered similar-sized Metridia and Calanus proved that Pareuchaeta consumed the less-active Calanus, but not the Metridia. © 2013 Copyright Taylor and Francis Group, LLC.

Facile synthesis of Curcuma longa tuber powder engineered metal nanoparticles for bioimaging applications

Science.gov (United States)

Sankar, Renu; Rahman, Pattanathu K. S. M.; Varunkumar, Krishnamoorthy; Anusha, Chidambaram; Kalaiarasi, Arunachalam; Shivashangari, Kanchi Subramanian; Ravikumar, Vilwanathan

2017-02-01

Nanomaterials based fluorescent agents are rapidly becoming significant and promising transformative tools for improving medical diagnostics for extensive in vivo imaging modalities. Compared with conventional fluorescent agents, nano-fluorescence has capabilities to improve the in vivo detection and enriched targeting efficiencies. In our laboratory we synthesized fluorescent metal nanoparticles of silver, copper and iron using Curcuma longa tuber powder by simple reduction. The physicochemical properties of the synthesized metal nanoparticles were attained using UV-visible spectrophotometry, scanning electron microscopy with EDAX spectroscopy, dynamic light scattering, Fourier-transform infrared spectroscopy and X-ray diffraction. The Curcuma longa tuber powder has one of the bioactive compound Curcumin might act as a capping agent during the synthesis of nanoparticles. The synthesized metal nanoparticles fluorescence property was confirmed by spectrofluorometry. When compared with copper and iron nanoparticles the silver nanoparticles showed high fluorescence intensity under spectrofluorometry. Moreover, in vitro cell images of the silver nanoparticles in A549 cell lines also correlated with the results of spectrofluorometry. These silver nanoparticles show inspiring cell-imaging applications. They enter into cells without any further modifications, and the fluorescence property can be utilized for fluorescence-based cell imaging applications.

Testing Extended Accounts in Scheduled Conservation of Open Woodlands with Permanent Livestock Grazing: Dehesa de la Luz Estate Case Study, Arroyo de la Luz, Spain

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Pablo Campos

2017-11-01

Full Text Available Standard Economic Accounts for Agriculture and Forestry do not measure the ecosystem services and intermediate products embedded in the final products recorded, and omit the private non-commercial intermediate products and self-consumption of private amenities. These limitations of the standard accounts are addressed by the extended Agroforestry Accounting System, which is being tested at the publicly-owned Dehesa de la Luz agroforestry estate. The extended accounts simulate conservation forestry of holm oak and cork oak for the current as well as successive rotation cycles during which scheduled conservation of the cultural woodland landscape of the Dehesa de la Luz is carried out, improving the natural physical growth of the firewood and cork. The estimated results for 2014 reveal that private ecosystem services make up 50% of the firewood and grazing products consumed; the private environmental income accounts for 13% of the total private income; and the private environmental asset represents 53% of the total opening capital. The net value added is more than 2.3 times the amount estimated using the standard accounts. The landowner donates intermediate products of non-commercial services at a value of 85 €/ha, which are used to enhance the supply of public products.

Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists.

Science.gov (United States)

de Souza Tavares, Wagner; Akhtar, Yasmin; Gonçalves, Gabriel Luiz Padoan; Zanuncio, José Cola; Isman, Murray B

2016-11-02

Curcuma longa has well-known insecticidal and repellent effects on insect pests, but its impact on Trichoplusia ni is unknown. In this study, the compound ar-turmerone, extracted and purified from C. longa rhizomes, was identified, and its insecticidal effects, along with turmeric powder, curcuminoid pigments and crude essential oil were evaluated against this important agricultural pest. The role of natural (sesamol and piperonal) and synthetic [piperonyl butoxide (PBO)] synergists under laboratory and greenhouse conditions were also evaluated. The concentration of ar-turmerone in C. longa rhizomes harvested was 0.32% (dwt). Turmeric powder and its derivatives caused 10-20% mortality in third instar T. ni at a very low dose (10 μg/larva). Addition of PBO increased toxicity of turmeric powder and its derivatives (90-97% mortality) in most binary combinations (5 μg of turmeric powder or its derivatives +5 μg of PBO), but neither piperonal nor sesamol were active as synergists. The compound ar-turmerone alone and the combination with PBO reduced larval weight on treated Brassica oleracea in the laboratory and in greenhouse experiments, compared with the negative control. The compound ar-turmerone could be used as a low cost botanical insecticide for integrated management of cabbage looper in vegetable production.

De Novo Transcriptome Assembly (NGS) of Curcuma longa L. Rhizome Reveals Novel Transcripts Related to Anticancer and Antimalarial Terpenoids

Science.gov (United States)

Jayakumar, Vasanthan; Damodaran, Anand C.; Rao, Sudha Narayana; Katta, Mohan A. V. S. K.; Gopinathan, Sreeja; Sarma, Santosh Prasad; Senthilkumar, Vanitha; Niranjan, Vidya; Gopinath, Ashok; Mugasimangalam, Raja C.

2013-01-01

Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuma longa L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been attributed to lower incidences of gastrointestinal cancers. Curcumin, a secondary metabolite isolated from the rhizomes of this plant has been shown to have significant anticancer properties, in addition to antimalarial and antioxidant effects. We sequenced the transcriptome of the rhizome of the 3 varieties of Curcuma longa L. using Illumina reversible dye terminator sequencing followed by de novo transcriptome assembly. Multiple databases were used to obtain a comprehensive annotation and the transcripts were functionally classified using GO, KOG and PlantCyc. Special emphasis was given for annotating the secondary metabolite pathways and terpenoid biosynthesis pathways. We report for the first time, the presence of transcripts related to biosynthetic pathways of several anti-cancer compounds like taxol, curcumin, and vinblastine in addition to anti-malarial compounds like artemisinin and acridone alkaloids, emphasizing turmeric's importance as a highly potent phytochemical. Our data not only provides molecular signatures for several terpenoids but also a comprehensive molecular resource for facilitating deeper insights into the transcriptome of C. longa. PMID:23468859

De Novo transcriptome assembly (NGS of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids.

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Ramasamy S Annadurai

Full Text Available Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuma longa L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been attributed to lower incidences of gastrointestinal cancers. Curcumin, a secondary metabolite isolated from the rhizomes of this plant has been shown to have significant anticancer properties, in addition to antimalarial and antioxidant effects. We sequenced the transcriptome of the rhizome of the 3 varieties of Curcuma longa L. using Illumina reversible dye terminator sequencing followed by de novo transcriptome assembly. Multiple databases were used to obtain a comprehensive annotation and the transcripts were functionally classified using GO, KOG and PlantCyc. Special emphasis was given for annotating the secondary metabolite pathways and terpenoid biosynthesis pathways. We report for the first time, the presence of transcripts related to biosynthetic pathways of several anti-cancer compounds like taxol, curcumin, and vinblastine in addition to anti-malarial compounds like artemisinin and acridone alkaloids, emphasizing turmeric's importance as a highly potent phytochemical. Our data not only provides molecular signatures for several terpenoids but also a comprehensive molecular resource for facilitating deeper insights into the transcriptome of C. longa.

Curcuminoid content of Curcuma longa L. and Curcuma xanthorrhiza rhizome based on drying method with NMR and HPLC-UVD

Science.gov (United States)

Hadi, S.; Artanti, A. N.; Rinanto, Y.; Wahyuni, D. S. C.

2018-04-01

Curcuminoid, consisting of curcumin, demethoxycurcumin and bis demethoxycurcumin, is the major compound in Curcuma longa L. and Curcuma xanthorrhiza rhizome. It has been known to have a potent antioxidants, anticancer, antibacteria activity. Those rhizomes needs to be dried beforehand which influenced the active compounds concentration. The present work was conducted to assess the curcuminoid content of C. longa L. and C. xanthorrhiza based on drying method with Nuclear Magnetic Resonance (NMR) and High Pressure Liquid Chromatography (HPLC)-UVD. Samples were collected and dried using freeze-drying and oven method. The latter is the common method applied in most drying method at herbal medicine preparation procedure. All samples were extracted using 96% ethanol and analyzed using NMR and HPLC-UVD. Curcuminoid as a bioactive compound in the sample exhibited no significant difference and weak significant difference in C. xanthorrhiza and C. longa L., respectively. HLPC-UVD as a reliable analytical method for the quantification is subsequently used to confirm of the data obtained by NMR. It resulted that curcuminoid content showed no significant difference in both samples. This replied that curcuminoids content in both samples were stable into heating process. These results are useful information for simplicia standardization method in pharmaceutical products regarding to preparation procedure.

Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Science.gov (United States)

de Souza Tavares, Wagner; Akhtar, Yasmin; Gonçalves, Gabriel Luiz Padoan; Zanuncio, José Cola; Isman, Murray B.

2016-01-01

Curcuma longa has well-known insecticidal and repellent effects on insect pests, but its impact on Trichoplusia ni is unknown. In this study, the compound ar-turmerone, extracted and purified from C. longa rhizomes, was identified, and its insecticidal effects, along with turmeric powder, curcuminoid pigments and crude essential oil were evaluated against this important agricultural pest. The role of natural (sesamol and piperonal) and synthetic [piperonyl butoxide (PBO)] synergists under laboratory and greenhouse conditions were also evaluated. The concentration of ar-turmerone in C. longa rhizomes harvested was 0.32% (dwt). Turmeric powder and its derivatives caused 10–20% mortality in third instar T. ni at a very low dose (10 μg/larva). Addition of PBO increased toxicity of turmeric powder and its derivatives (90–97% mortality) in most binary combinations (5 μg of turmeric powder or its derivatives +5 μg of PBO), but neither piperonal nor sesamol were active as synergists. The compound ar-turmerone alone and the combination with PBO reduced larval weight on treated Brassica oleracea in the laboratory and in greenhouse experiments, compared with the negative control. The compound ar-turmerone could be used as a low cost botanical insecticide for integrated management of cabbage looper in vegetable production. PMID:27804972

De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids.

Science.gov (United States)

Annadurai, Ramasamy S; Neethiraj, Ramprasad; Jayakumar, Vasanthan; Damodaran, Anand C; Rao, Sudha Narayana; Katta, Mohan A V S K; Gopinathan, Sreeja; Sarma, Santosh Prasad; Senthilkumar, Vanitha; Niranjan, Vidya; Gopinath, Ashok; Mugasimangalam, Raja C

2013-01-01

Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuma longa L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been attributed to lower incidences of gastrointestinal cancers. Curcumin, a secondary metabolite isolated from the rhizomes of this plant has been shown to have significant anticancer properties, in addition to antimalarial and antioxidant effects. We sequenced the transcriptome of the rhizome of the 3 varieties of Curcuma longa L. using Illumina reversible dye terminator sequencing followed by de novo transcriptome assembly. Multiple databases were used to obtain a comprehensive annotation and the transcripts were functionally classified using GO, KOG and PlantCyc. Special emphasis was given for annotating the secondary metabolite pathways and terpenoid biosynthesis pathways. We report for the first time, the presence of transcripts related to biosynthetic pathways of several anti-cancer compounds like taxol, curcumin, and vinblastine in addition to anti-malarial compounds like artemisinin and acridone alkaloids, emphasizing turmeric's importance as a highly potent phytochemical. Our data not only provides molecular signatures for several terpenoids but also a comprehensive molecular resource for facilitating deeper insights into the transcriptome of C. longa.

La luz del origen del universo

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Casas, Alberto

2015-10-01

Full Text Available Penzias and Wilson discovered the cosmic microwave background, a luminous echo of the Big Bang, in 1965. The amount of information encoded in this relic of the early universe is truly extraordinary. At present, the most precise data about the origin and structure of the universe comes from the study of this primordial light, the full potential of which has yet to be explored.En 1965 se descubrió el fondo de radiación de microondas, un eco luminoso de la Gran Explosión (Big Bang. La cantidad de información contenida en esta reliquia del universo primitivo es verdaderamente extraordinaria. En la actualidad los datos más precisos sobre el origen y estructura del universo provienen del estudio de esta luz primigenia, que aún no ha sido explorada en todo su potencial.

Dimensão da maturidade à luz da logoterapia

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Libardi, Tadeu Antonio

2008-01-01

Full Text Available O artigo aborda o tema da maturidade humana à luz da logoterapia, fundada por Viktor Emil Frankl. Nos dias de hoje, existe a frustração existencial, não mais a sexual, como analisada por Freud. Cada ser humano, como pessoa livre e responsável e tendo como meta a busca da maturidade, vai percorrendo seu próprio caminho, que o leva à ceitação de si, de seus limites e potencialidades e ao relacionamento social e religioso, capacitando-o ao confronto com o sofrimento humano

Aparente sencillez. Luz y dispositivos en la arquitectura japonesa

OpenAIRE

Diana Errazti, Argiñe

2018-01-01

Cada cultura, cada individuo y cada arquitectura, responden a determinados eventos que a lo largo de la historia han modelado su carácter y su personalidad. En el caso de Japón, la arquitectura ha sido modelada, principalmente, por la existencia y desarrollo de su religión nativa, el Sintoísmo, que le ha otorgado una traducción muy particular del concepto de luz y de sombra, lo que ha llevado, además, a un desarrollo muy particular de las formas y del espacio arquitectóni...

SOBRE LOS EVENTOS QUE SE DESATAN CUANDO LA LUZ INCIDE SOBRE UNA NANOESTRUCTURA

Directory of Open Access Journals (Sweden)

Álvaro Morales

2016-03-01

Full Text Available La interacción de la radiación con la materia es un hecho cotidiano en la naturaleza, se pueden recordar  fenómenos como la fotosíntesis, interacción de la luz solar con las plantas para generar alimento y la generación de la vitamina D en nuestra piel. Con la formación de sistemas masivos, galaxias, estrellas, planetas, en los albores del universo, se establece la radiación electromagnética, la cual se caracteriza por contener ondas con longitudes desde los kilómetros, ondas de radio, hasta longitudes menores que 10-12 m, rayos gama, pasando por la radiación visible detectada por nuestra retina. En este artículo divulgativo, dirigido al público en general, basado en la investigación de Duque et al [1], se va a tratar acerca de los conceptos involucrados en la interacción de la luz con nanoestructuras semiconductoras.

Employment and income generation within the framework of the 'Luz para todos' program in the State of Amazonas, Brazil; Geracao de emprego e renda no ambito do programa Luz para Todos no estado do Amazonas

Energy Technology Data Exchange (ETDEWEB)

Souza, Rubem Cesar Rodrigues; Moraes, Betsy Eddy Praia; Souza, Cristiane Daliassi Ramos de [Universidade Federal do Amazonas (UFAM), Manaus, AM (Brazil). Centro de Desenvolvimento Energetico Amazonico

2008-07-01

The low level of the electric demand to be accomplished in the isolated Amazon communities, associated to the low purchasing power of those populations and the high costs for electrification of these, they impose the implementation of concrete actions of generation of job and income when it intend to assure the universalization of the electric power service in isolated Amazon communities, as ir the case of the program 'Luz para Todos'. The present article shows that is being developed by the committee state manager of the program 'Luz para Todos' in the amazon state, demonstrating that it is possible to assure good results since the effective involvement of several agents is made possible. (author)

Anti-Inflammatory Activity of Polysaccharide Fraction of Curcuma longa Extract (NR-INF-02).

Science.gov (United States)

Illuri, Ramanaiah; Bethapudi, Bharathi; Anandakumar, Senthilkumar; Murugan, Sasikumar; Joseph, Joshua A; Mundkinajeddu, Deepak; Agarwal, Amit; Chandrasekaran, C V

2015-01-01

The aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction (F1) of Curcuma longa extract (NR-INF-02) in classical rodent models of inflammation. F1 was evaluated for its acute oral toxicity and found to be safe upto 5000 mg/kg body weight in rats. The anti-inflammatory activity of F1 was evaluated in acute (carrageenan - induced paw edema; xylene - induced ear edema) and chronic (cotton pellet - induced granuloma) models of inflammation. The results of the study demonstrated that F1 significantly (p ≤ 0.05) inhibited carrageenan-induced paw edema at 1 h and 3 h at doses of 11.25, 22.5 and 45 mg/kg body weight in rats. Also, F1 at doses of 15.75, 31.5 and 63 mg/kg significantly inhibited the xylene induced ear edema in mice. In a chronic model, F1 at 11.25, 22.5 and 45 mg/kg doses produced significant reduction of wet and dry weights of cotton pellets in rats. Overall results indicated that F1 of NR-INF-02 significantly attenuated acute and chronic inflammation in rodent models. This study emphasizes on the importance of Curcuma longa polysaccharide's role in acute and chronic inflammation.

Bioactive chemical constituents of Curcuma longa L. rhizomes extract inhibit the growth of human hepatoma cell line (HepG2).

Science.gov (United States)

Abdel-Lateef, Ezzat; Mahmoud, Faten; Hammam, Olfat; El-Ahwany, Eman; El-Wakil, Eman; Kandil, Sherihan; Abu Taleb, Hoda; El-Sayed, Mortada; Hassenein, Hanaa

2016-09-01

The present study was designed to identify the chemical constituents of the methanolic extract of Curcuma longa L. rhizomes and their inhibitory effect on a hepatoma cell line. The methanolic extract was subjected to GC-MS analysis to identify the volatile constituents and the other part of the same extract was subjected to liquid column chromatographic separation to isolate curcumin. The inhibition of cell growth in the hepatoma cell line and the cytopathological changes were studied. GC-MS analysis showed the presence of fifty compounds in the methanolic extract of C. longa. The major compounds were ar-turmerone (20.50 %), β-sesquiphellandrene (5.20 %) and curcumenol (5.11 %). Curcumin was identified using IR, 1H and 13C NMR. The inhibition of cell growth by curcumin (IC50 = 41.69 ± 2.87 μg mL-1) was much more effective than that of methanolic extract (IC50 = 196.12 ± 5.25 μg mL-1). Degenerative and apoptotic changes were more evident in curcumin- treated hepatoma cells than in those treated with the methanol extract. Antitumor potential of the methanolic extract may be attributed to the presence of sesquiterpenes and phenolic constituents including curcumin (0.051 %, 511.39 μg g-1 dried methanol extract) in C. longa rhizomes.

Effect of gamma irradiation on curcuminoids and volatile oils of fresh turmeric (Curcuma longa)

Energy Technology Data Exchange (ETDEWEB)

Dhanya, R. [P.G. Department of Botany and Research Centre, Sir Syed College, Taliparamba 670142, Kerala (India); Mishra, B.B. [Food Technology Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Khaleel, K.M., E-mail: khaleelchovva@yahoo.co.in [P.G. Department of Botany and Research Centre, Sir Syed College, Taliparamba 670142, Kerala (India)

2011-11-15

In our earlier study a radiation dose of 5 kGy was reported to be suitable for microbial decontamination and shelf life extension of fresh turmeric (Curcuma longa), while maintaining its quality attributes. In continuation of that work, the effect of gamma radiation on curcuminoids and volatile oil constituents in fresh turmeric was studied. Fresh peeled turmeric rhizomes were gamma irradiated at doses of 1, 3 and 5 kGy. Curcuminoid content and volatile oils were analyzed by reverse phase HPLC and GC-MS, respectively. The curcuminoid content was slightly increased by gamma irradiation. No statistically significant changes were observed due to irradiation in majority of the volatile oil constituents. - Highlights: > Effect of gamma radiation on curcuminoids and volatile oil constituents in fresh turmeric (Curcuma longa) was studied. > Fresh peeled turmeric rhizomes were gamma irradiated at doses of 1, 3 and 5 kGy. > Curcuminoid content and the volatile oils were analyzed by reverse phase HPLC and GC-MS, respectively. > Curcuminoid content was slightly increased by gamma irradiation. > No statistically significant changes were observed due to irradiation in majority of the volatile oil constituents.

Effect of gamma irradiation on curcuminoids and volatile oils of fresh turmeric (Curcuma longa)

International Nuclear Information System (INIS)

Dhanya, R.; Mishra, B.B.; Khaleel, K.M.

2011-01-01

In our earlier study a radiation dose of 5 kGy was reported to be suitable for microbial decontamination and shelf life extension of fresh turmeric (Curcuma longa), while maintaining its quality attributes. In continuation of that work, the effect of gamma radiation on curcuminoids and volatile oil constituents in fresh turmeric was studied. Fresh peeled turmeric rhizomes were gamma irradiated at doses of 1, 3 and 5 kGy. Curcuminoid content and volatile oils were analyzed by reverse phase HPLC and GC-MS, respectively. The curcuminoid content was slightly increased by gamma irradiation. No statistically significant changes were observed due to irradiation in majority of the volatile oil constituents. - Highlights: → Effect of gamma radiation on curcuminoids and volatile oil constituents in fresh turmeric (Curcuma longa) was studied. → Fresh peeled turmeric rhizomes were gamma irradiated at doses of 1, 3 and 5 kGy. → Curcuminoid content and the volatile oils were analyzed by reverse phase HPLC and GC-MS, respectively. → Curcuminoid content was slightly increased by gamma irradiation. → No statistically significant changes were observed due to irradiation in majority of the volatile oil constituents.

A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity

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Minakshi Rana

2016-07-01

Full Text Available The TLR/IL-1R pathway is a critical signaling module that is misregulated in pathologies like inflammation and cancer. Extracts from turmeric (Curcuma longa L. enriched in curcumin and carbonyls like turmerones have been shown to exert potent anti-inflammatory effects. The present study evaluated the anti-inflammatory activity, cytotoxic effect and the underlying mechanism of a novel chemically modified, non-carbonyl compound enriched Curcuma longa L. (C. longa extract (CMCE. CMCE (1 or 10 µg/mL; 14 h significantly decreased LPS (50-100 ng/mL induced TNF-α and IL-1β production in THP-1 cells, human, and mouse whole blood as measured by ELISA. LPS-induced IRAK1, MAPK activation, TLR4 expression, TLR4-MyD88 interaction and IκBα degradation were significantly reduced in CMCE pre-treated THP-1 cells as assessed by Western blotting. CMCE (30, 100 and 300 mg/kg; 10 days p.o. pre-treated and LPS (10 mg/kg challenged Swiss mice exhibited attenuated plasma TNF-α, IL-1β, nitrite, aortic iNOS expression and vascular dysfunction. In a PI permeability assay, cell lines derived from acute myeloid leukemia were most sensitive to the cytotoxic effects of CMCE. Analysis of Sub-G1 phase, Annexin V-PI positivity, loss of mitochondrial membrane potential, increased caspase-3 and PARP-1 activation confirmed CMCE induced apoptosis in HL-60 cells. IRAK inhibition also sensitized HL-60 cells to CMCE induced cytotoxicity. The present study defines the mechanism underlying the action of CMCE and suggests a therapeutic potential for its use in sepsis and leukemia.

A critical analysis of the 'Programa Luz Para Todos' for the electrification of remote communities in the Amazon region; Uma analise critica do Programa Luz Para Todos para a eletrificacao de comunidades isoladas na regiao Amazonica

Energy Technology Data Exchange (ETDEWEB)

Teixeira, Andre Frazao [Fundacao de Amparo a Pesquisa do Estado do Amazonas (FAPEAM), Manaus, AM (Brazil); Lopes, Davi Gabriel; Cavaliero, Carla Kazue Nakao [Universidade Estadual de Campinas (FEM/UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica

2010-07-01

This article presents a critical review of 'Luz para Todos' (LpT) as a rural electricity deployment program and its viability as a starter for a development process to isolated communities from Amazon region. We analyzed the functionality using data from the beginning of the program until 2009, as well the methodology and organization of the investments over 'Luz para Todos' program as a development starter, preferably sustainable, for the isolated communities from Amazon region. We concluded that a discussion is mandatory, as well a review of some important points, such as estimation of available financial resources; mechanisms used to motivate electric utilities that serve the isolated communities especially in the Amazon region; and the relationship between energy and development proposed by the program. (author)

Curcuma longa extract – Haldi: A safe, eco-friendly natural cytoplasmic stain

OpenAIRE

Suryawanshi, Hema; Naik, Rupali; Kumar, Pramod; Gupta, Rolly

2017-01-01

Background: Eosin is most widely used synthetic dye belonging to the xanthene group. These dyes are efficient but are hazardous to human and animal health. With the increasing awareness of a green earth, it is advisable to use more of eco-friendly and biodegradable material which can be effectively achieved by the use of natural dyes obtained from plants and other natural sources. Turmeric, available as Curcuma longa (domestic), has long been in use in the subcontinent as a spice and flavorin...

UHV equipment for light line of the Laboratorio Nacional de Luz Sincrotron - LNLS

International Nuclear Information System (INIS)

Pacheco, J.G.; Fonseca, P.T.; Castro, A.R.B. de

1991-01-01

The construction of light line for spectral range from 12 to 310 eV of Laboratorio Nacional de Luz Sincrotron (LNLS) is presented. The basic parameters of light line are shown. The components of UHV constructed in the LNLS considering installation aspects and final results are exposed. (M.C.K.)

Merger of aspects of the 'Programa Luz para Todos' in the regulation of ANEEL; Incorporacao de aspectos do Programa Luz para Todos na regulacao da ANEEL

Energy Technology Data Exchange (ETDEWEB)

Camargo, Ednaldo Jose Silva de [Universidade de Sao Paulo (IEE/USP), SP (Brazil). Inst. de Eletrotecnica e Energia; Ribeiro, Fernando Selles [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica

2009-07-01

This study aims to examine the relationship between concessionaire and requesting public service of electric energy from the changes brought about by the 'Programa Luz para Todos', for residents of rural areas. The concept of access to electricity as a right for all Brazilians and as an essential right of citizenship, also studying processing of legislation in order to accomplish this right. Examines the advances offered by the 'Programa Luz para Todos' - both in terms of social inclusion which provides, as the increase in energy demand and consequent increase of the distribution market - which regulation is based on document entitled 'Manual de Operationalizacao' and was formally accepted by utilities to distribute power and cooperatives in rural electrification. Presents a discussion about the same subject under the 'Poder Legislativo', in a bill in the 'Camara Federal' procedure. Demonstrates the existence of a desire for maintaining the progress achieved in various spheres of government. Proposes ANEEL's incorporation of some aspects of the modern setting, in particular with regard to the concept of the 'Ponto de Entrega' as defined in Article 9 of Resolution 456/00. (author)

The Effects of Different Doses of Curcuma longa Aqueous Extract on Memory Retention and Retrieval in Male Mice

Directory of Open Access Journals (Sweden)

2016-12-01

Full Text Available Background and Objectives: Curcumin belongs to ginger family, which is used as food and drug from ancient times. Different studies have shown beneficial effects of curcumin on peptic ulcer, rheumatoid arthritis, asthma, and various types of cancer. In this study, the effect of different doses of Curcuma longa aqueous extract on memory retention and retrieval of mice, was investigated using passive avoidance apparatus. Methods: Mice were divided into 6 groups of 8 each for memory retention test and 6 groups of 8 each for memory retrieval test {experimental groups receiving the extract intraperitoneally at doses of 100, 200, 400, 800mg/kg, blank group, and control group}. In memory retention test, the curcumin extract was administered immediately after electric shock, while in the memory retrieval test, it was administered 24 h after receiving electric shock. To compare the complete stepping in the experiment days, One-way ANOVA and post-test LSD were used. The level of significance was considered p<0.05. Results: In this study, curcuma longa aqueous extract significantly increased memory retention and retrieval on the 4th day compared to blank and control groups. The best response for memory retention was obtained at the dose of 100mg/kg and for memory retrieval at the dose of 200mg/kg. Conclusion: According to the results of this study, it seems that Curcuma longa aqueous extract improves memory retention and retrieval in healthy mice.  

RuBisCO in Non-Photosynthetic Alga Euglena longa: Divergent Features, Transcriptomic Analysis and Regulation of Complex Formation

Czech Academy of Sciences Publication Activity Database

Záhonová, K.; Füssy, Z.; Oborník, Miroslav; Eliáš, M.; Yurchenko, V.

2016-01-01

Roč. 11, č. 7 (2016), e0158790 E-ISSN 1932-6203 Institutional support: RVO:61388971 Keywords : FLAGELLATE ASTASIA-LONGA * OXYGENASE SMALL SUBUNIT * A/B-BINDING-PROTEIN Subject RIV: EE - Microbiology, Virology Impact factor: 2.806, year: 2016

Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes.

Science.gov (United States)

Ponnusamy, Sudha; Zinjarde, Smita; Bhargava, Shobha; Rajamohanan, P R; Ravikumar, Ameeta

2012-12-15

Curcuma longa rhizome is used extensively in culinary preparations in Far East and South-East Asia. Health benefits of curcuminoids from C. longa as antioxidants, anti-cancer and anti-inflammatory molecules have been well documented. We report here for the first time that Bisdemethoxycurcumin (BDMC) from C. longa, acts as an inhibitor to inactivate human pancreatic α-amylase, a therapeutic target for oral hypoglycemic agents in type-2 diabetes. Bioactivity guided isolation of rhizome isopropanol extract led to the identification by HPLC and NMR of BDMC as a lead small molecule inhibitor of porcine and human pancreatic α-amylase with an IC(50) value of 0.026 and 0.025 mM, respectively. Kinetic analysis revealed that using starch as the substrate, HPA exhibited an uncompetitive mode of inhibition with an apparent K(i) of 3.0 μM. The study gains importance as BDMC could be a good drug candidate in development of new inhibitors of HPA and of functional foods for controlling starch digestion in order to reduce post-prandial hyperglycemia. Copyright © 2012 Elsevier Ltd. All rights reserved.

Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling.

Science.gov (United States)

Nam, Sung Min; Choi, Jung Hoon; Yoo, Dae Young; Kim, Woosuk; Jung, Hyo Young; Kim, Jong Whi; Yoo, Miyoung; Lee, Sanghee; Kim, Chul Jung; Yoon, Yeo Sung; Hwang, In Koo

2014-06-01

Aging is a progressive process, and it may lead to the initiation of neurological diseases. In this study, we investigated the effects of wild Indian Curcuma longa using a Morris water maze paradigm on learning and spatial memory in adult and D-galactose-induced aged mice. In addition, the effects on cell proliferation and neuroblast differentiation were assessed by immunohistochemistry for Ki67 and doublecortin (DCX) respectively. The aging model in mice was induced through the subcutaneous administration of D-galactose (100 mg/kg) for 10 weeks. C. longa (300 mg/kg) or its vehicle (physiological saline) was administered orally to adult and D-galactose-treated mice for the last three weeks before sacrifice. The administration of C. longa significantly shortened the escape latency in both adult and D-galactose-induced aged mice and significantly ameliorated D-galactose-induced reduction of cell proliferation and neuroblast differentiation in the subgranular zone of hippocampal dentate gyrus. In addition, the administration of C. longa significantly increased the levels of phosphorylated CREB and brain-derived neurotrophic factor in the subgranular zone of dentate gyrus. These results indicate that C. longa mitigates D-galactose-induced cognitive impairment, associated with decreased cell proliferation and neuroblast differentiation, by activating CREB signaling in the hippocampal dentate gyrus.

Refração por retinoscopia com luz em faixa em cães

OpenAIRE

Ranzani,J.J.T.; Mobricci,L.A.L.; Carvalho,L.R.; Brandão,C.V.S.

2008-01-01

A refração ocular por retinoscopia com luz em faixa em 10 cães normais, sem raça definida, demonstrou que a maioria dos animais, independentemente do porte, apresentou tendência à hipermetropia, além de anisometropia e astigmatismo.

Como queimar um papel à luz de Sírio

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Guilherme de Almeida

2013-07-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2013v30n2p440 É bem conhecida a experiência de queimar um papel com uma lupa. Será possível, com uma lupa gigantesca, fazer o mesmo utilizando a luz de uma outra estrela? Que requisitos serão necessários? Este artigo aborda as diversas perspectivas sobre o assunto, mostrando as limitações e as possibilidades práticas de tal procedimento. Trata-se de uma exploração conceitual e não de um projeto construtivo.

From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation.

Science.gov (United States)

Frank, Annika; Abu-Lafi, Saleh; Adawi, Azmi; Schwed, Johannes S; Stark, Holger; Rayan, Anwar

2017-10-01

The aim was to evaluate the activity of seven medicinal, anti-inflammatory plants at the hH 4 R with focus on defined chemical compounds from Curcuma longa. Activities were analyzed with membrane preparations from Sf9 cells, transiently expressing the hH 4 R, G αi2 and G β1γ2 subunits. From the methanolic extract of C. longa curcumin (1), demethoxycurcumin (2) and bis(4-hydroxy-cinnamoyl)methane (3) were isolated, purified with HPLC (elution-time 10.20, 9.66, 9.20 min, respectively) and together with six additional extracts, were characterized via radioligand binding studies at the hH 4 R. Compounds from C. longa were the most potent ligands at the hH 4 R. They exhibited estimated K i values of 4.26-6.26 µM (1.57-2.31 µg/mL) (1); 6.66--8.97 µM (2.26-3.04 µg/mL) (2) and 10.24-14.57 µM (3.16-4.49 µg/mL) (3) (95% CI). The estimated K i value of the crude extract of curcuma was 0.50-0.81 µg/mL. Fractionated curcumin and the crude extract surpassed the effect of pure curcumin with a K i value of 5.54 µM or 2.04 µg/mL [95% CI (4.47-6.86 µM), (1.65-2.53 µg/mL)]. Within this study, defined compounds of C. longa were recognized as potential ligands and reasonable lead structures at the hH 4 R. The mode of anti-inflammatory action of curcumin was further elucidated and the role of extracts in traditional phytomedicine was strengthened.

Curcuma longa extract - Haldi: A safe, eco-friendly natural cytoplasmic stain.

Science.gov (United States)

Suryawanshi, Hema; Naik, Rupali; Kumar, Pramod; Gupta, Rolly

2017-01-01

Eosin is most widely used synthetic dye belonging to the xanthene group. These dyes are efficient but are hazardous to human and animal health. With the increasing awareness of a green earth, it is advisable to use more of eco-friendly and biodegradable material which can be effectively achieved by the use of natural dyes obtained from plants and other natural sources. Turmeric, available as Curcuma longa (domestic), has long been in use in the subcontinent as a spice and flavoring agent in most food preparations. Its health benefit as a natural antibiotic and anti-inflammatory has been successfully established by several researchers. The intense yellow color imparted by turmeric inspired us to explore its efficacy as a potential alternative for eosin in routine histopathological procedures. The aim of this was to explore the efficacy of turmeric extract as a stand-alone counterstain for hematoxylin and its comparative assessment with routine H and E staining. The rhizomes of C. longa were cut into small pieces, dried and milled. This powder was dissolved into alcohol and centrifuged using a centrifugal machine. The supernatant was then collected with the help of micropipette. This supernatant was used as a counterstain for hematoxylin. The data were analyzed using Mann-Whitney U test with Statistical Package for the Social Sciences version 15.0 (SPSS Inc.,). The P value obtained was statistically insignificant ( P > 0.05). Although eosin is the most efficient counterstain for hematoxylin, turmeric can also be used as an alternative for eosin.

Relações interpessoais à luz do psicodrama/The interpersonal relations in view of psychodrama

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Marinalva Imaculada Cuzin

Full Text Available CUZIN, M. I. As relações interpessoais à luz do psicodrama.389fl.2008. Tese (Doutorado em Educação – Faculdade de Educação, Universidade Estadual de Campinas, Campinas. 2008.

Relación de la radiación ultravioleta y el pterigión primario Relation of ultraviolet radiation and primary pterygium

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Belmary Aragonés Cruz

2009-06-01

Full Text Available El pterigión está presente a nivel mundial, pero es más común en climas cálidos y secos, predomina en países comprendidos entre 0º y 30º de latitud norte y sur. Existe evidencia epidemiológica en estudios poblacionales experimentales y observacionales que confirman que la radiación ultravioleta es el desencadenante inicial en la aparición del pterigión y un factor de riesgo significativo en su desarrollo. Los fenómenos físicos y climatológicos que explican la patogenia del pterigión son poco conocidos. La epidemiología del pterigión es una herramienta básica para conocer tanto su incidencia como su prevalencia. A partir de esta revisión nos propusimos reflexionar acerca del pterigión como marcador del grado de insolación del organismo y enfatizar en cuanto a la importancia de protección ante la posible exposición a la radiación ultravioleta en el resultado final de una cirugía de pterigión.Pterygium is present worldwide but it is more common in dry warm climates and predominates in countries situated 0º and 30º on North and South latitudes. There are epidemiological pieces of evidence in experimental and observational population studies that confirm that ultraviolet radiation is the initial unleashing factor in occurrence of pterygium and a significant risk factor for its development. The physical and climate phenomena accounting for the pathogeny of pterygium are almost unknown. Pterygium epidemiology is a basic tool for identifying its incidence and prevalence. On the basis of this review, we intended to make reflections on pterygium as a marker of degree of insolation of the human body and to emphasize the importance of protection against possible exposure to ultraviolet radiations in the final outcome of pterygium surgery.

Evaluating in-home water purification methods for communities in Texas on the border with Mexico Evaluación de métodos domésticos de purificación de agua para comunidades de Texas fronterizas con México

Directory of Open Access Journals (Sweden)

Patrick L. Gurian

2006-12-01

Full Text Available This study evaluated user preferences among three alternative in-home water treatment technologies suitable for households relying on trucked water in El Paso County, Texas, which is on the border with Mexico. The three technologies were: chlorination of household storage tanks, small-scale batch chlorination, and point-of-use ultraviolet disinfection. Fifteen households used each of the three technologies in succession for roughly four weeks each during April through June of 2004. Data were collected on treated water quality, and a face-valid survey was administered orally to assess user satisfaction with the technologies on a variety of attributes. Treatment with a counter-top ultraviolet disinfection system received statistically significantly higher ratings for taste and odor and likelihood of future use than the other two approaches. Ultraviolet disinfection and small-scale batch chlorination both received significantly higher ratings for ease of use than did storage tank chlorination. Over-chlorination was a common problem with both batch chlorination and storage tank chlorination. Water quality in the households using trucked water is now higher than was reported by a previous study, suggesting that water quality has improved over time.Este estudio evaluó las preferencias de los consumidores de tres tecnologías domésticas para el tratamiento del agua, apropiadas para viviendas del condado de El Paso, Texas, situado en la frontera con México, que dependen del agua transportada en camiones. Las tres tecnologías fueron cloración de los tanques domésticos de almacenamiento, cloración de pequeños lotes de agua y desinfección mediante luz ultravioleta en el punto de dispensación. Quince viviendas utilizaron sucesivamente cada una de las tres tecnologías durante aproximadamente cuatro semanas entre abril y junio de 2004. Se registraron los datos sobre la calidad del agua tratada y se realizó una encuesta oral aceptada por los

Uma leitura intertextual da poesia de Alberto Caeiro à luz da sabedoria zen-budista

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Márcia Munir Miguel Feitosa

2011-10-01

Full Text Available Análise da poesia de Alberto Caeiro, heterônimo de Fernando Pessoa, à luz da filosofia zen-budista, tanto no que concerne ao culto da natureza, como no que diz respeito à questão do eu, inerente ao poeta português e à filosofia Zen. O estudo ainda inclui o levantamento das possíveis afinidades formais e estilísticas entre a poesia japonesa, representada pelos hai-kais, e a poesia sensacionalista de Caeiro.Análisis de la poesia de Alberto Caeiro, heterónimo de Fernando Pessoa a la luz de la filosofía zen-budista, tanto que concierne al culto de la naturaleza, como que dice respecto a la cuestión del yo, inherente al poeta portugués y a la filosofía zen. El estúdio aún incluye las posibles afinidades formales y estilísticas entre la poesia japonesa, representada por los hai-kais, y la poesia sensacionista de Caeiro.

Josef Svoboda: la luz construida = Josef Svoboda: the light constructed

Directory of Open Access Journals (Sweden)

Eugenio Bargueño Gómez

2012-09-01

Full Text Available Resumen Josef Svoboda (1920-2002, fue escenógrafo, arquitecto y director artístico de la Linterna Mágica en Praga. Es difícil encontrar en los últimos cien años un escenógrafo que haya aportado tanto al mundo de la escena por su desbordante capacidad creativa. Siempre estuvo dispuesto a resolver problemas con planteamientos novedosos de diseño introduciendo para ello aportaciones tecno­lógicas del momento. Indagó con imaginación sobre otros elementos escenográficos que no fuesen los clásicos diseños basados en corpóreos arquitectónicos, bastidores, etc., pero que determinaban de igual modo un espacio escénico. Amplió la espacialidad en la escena adjudicando capacidades al sonido y a la luz para conseguir una corporeidad psicológica al servicio de la dramaturgia y la estética. Introdujo en el diseño de sus escenografías imágenes con múltiples perspectivas que se percibían con un solo golpe de vista. También utilizó a los espectadores haciéndoles participes de lo que estaba sucediendo en escena. Creó los sistemas de polivisión y poliecrán, que combinaban el teatro y el ballet. Es responsable de la famosa cortina de luz blanca creada por unos focos diseñados por él y que reciben su nombre. Las proyecciones sobre espejos, técnica difícil de manejar en escena, fue otra de las innovaciones que Svoboda manejó magistralmente en sus escenografías. Palabras clave: Diseño escenográfico, Josef Svoboda, poliecrán, focos Svo­boda, cortina de luz, proyecciones sobre espejo permeable, Laterna Magika. Abstract Josef Svoboda (1920-2002 has been a scenographer, architect and artistic director of the Magic Lantern in Prague. It's difficult to find, in the last 100 years a scenographer that had contributed to the theater with his abundant creative ability. He has always been ready to solve problems with new design's approaches, introducing technological contributions just at that moment. He has investigated with imagination

Development of somatic embryos for genetic transformation in Curcuma longa L. and Curcuma mangga Valeton & Zijp

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Vachiraporn Pikulthong

2016-07-01

Full Text Available Buds from rhizomes of Curcuma longa L. variety ‘Chumphon’ and Curcuma mangga Valeton & Zijp variety ‘Phetchaburi’ were cultured on Murashige and Skoog (MS medium supplemented with 2.0 mg/L N6-benzyladenine (BA for multiple shoot induction. Their shoots were cultured on MS medium supplemented with various concentrations of one of two plant growth regulators or a combination of both—2,4-dichlorophenoxyacetic acid (2,4-D and naphthaleneacetic acid (NAA. Interestingly, the medium containing both auxins (5 mg/L 2,4-D and 5 mg/L NAA was best for somatic embryo induction after culturing for 4 weeks. Somatic embryo formation reached 87.50% for Curcuma longa and 95.83% for Curcuma mangga with a high quality of loose, friable and yellowish characters. The best conditions for the formation of shootlets occurred after transferring the somatic embryo to MS medium supplemented with 3.0 mg/L BA, 0.5 mg/L NAA and 3% maltose. The shootlets were rooted by transferring to MS medium containing 3.0 mg/L NAA. This is the first report of a complete in vitro regeneration system from somatic embryos of C. longa and C. mangga which was further used for gene manipulation in these plants. Diketide CoA synthase (DCS and curcumin synthase (CURS genes, which are the two genes involved in curcuminoid biosynthesis in turmeric, were cloned and transferred to these two species using Agrobacterium-mediated transformation. The presence of both target and marker genes, hpt, in the transformed somatic embryos was confirmed by polymerase chain reaction assay. After culturing, the transformed somatic embryos could survive for 4 weeks.

Essential oil from waste leaves of Curcuma longa L. alleviates skin inflammation.

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Kumar, Anant; Agarwal, Karishma; Singh, Monika; Saxena, Archana; Yadav, Pankaj; Maurya, Anil Kumar; Yadav, Anju; Tandon, Sudeep; Chanda, Debabrata; Bawankule, Dnyaneshwar U

2018-02-10

Curcuma longa L. is an important industrial crop used by medicinal and cosmetic industries in the world. Its leaves are a waste material after harvesting rhizomes. The aim of the study was to evaluate the chemical and pharmacological profile of essential oil from waste leaves of Curcuma longa (EOCl) against skin inflammation. EOCl was subjected to gas chromatography (GC) analysis for identification of essential oil constituents and its anti-inflammatory evaluation through in vitro and in vivo models. Chemical fingerprinting using GC and GC-MS analysis of EOCl revealed the presence of 11 compounds, representing 90.29% of the oil, in which terpinolene (52.88%) and α-phellandrene (21.13%) are the major components. In the in vitro testing EOCl inhibited the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) in lipopolysaccharide (LPS) and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the human keratinocyte cell line (HaCaT). Topical application of EOCl produced anti-inflammatory effects by reducing ear thickness, ear weight and ameliorating the level of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) at protein and mRNA levels as well as regulating the overproduction of oxidative markers and restoring the histopathological damage in a TPA-induced mouse model of inflammation. These findings of topical anti-inflammatory properties of EOCl provide a scientific basis for medicinal use of this plant material against inflammatory disorders.

Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach.

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Joshi, Deepmala; Mittal, Deepak Kumar; Shukla, Sangeeta; Srivastav, Sunil Kumar; Dixit, Vaibhav A

2017-07-05

The present investigation has been conducted to evaluate the therapeutic potential of Curcuma longa (200mgkg -1 , po) and curcumin (80mgkg -1 , po) for their hepatoprotective efficacy against mercuric chloride (HgCl 2 : 12μmolkg -1 , ip; once only) hepatotoxicity. The HgCl 2 administration altered various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides and cholesterol contents with a concomitant decline in protein and albumin concentration in serum which were restored towards control by therapy of Curcuma longa or curcumin. On the other hand, both treatments showed a protective effect on drug metabolizing enzymes viz. aniline hydroxylase (AH) and amidopyrine-N-demethylase (AND), hexobarbitone induced sleep time and BSP retention. Choleretic, 1,1-diphenyl-2-picryl-hydrazil (DPPH)-free radical scavenging activities and histological studies also supported the biochemical findings. The present study concludes that Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by HgCl 2 in rats. Copyright © 2017 Elsevier GmbH. All rights reserved.

[Study on extracting and separating curcuminoids from Curcuma longa rhizome using ultrasound strengthen by microemulsion].

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Yue, Chun-Hua; Zheng, Li-Tao; Guo, Qi-Ming; Li, Kun-Ping

2014-05-01

To establish a new method for the extraction and separation of curcuminoids from Curcuma longa rhizome by cloud-point preconcentration using microemulsions as solvent. The spectrophotometry was used to detect the solubility of curcumin in different oil phase, emulsifier and auxiliary emulsifier, and the microemulsion prescription was used for false three-phase figure optimization. The extraction process was optimized by uniform experiment design. The curcuminoids were separated from microemulsion extract by cloud-point preconcentration. Oil phase was oleic acid ethyl ester; Emulsifier was OP emulsifier; Auxiliary emulsifier was polyethylene glycol(peg) 400; The quantity of emulsifier to auxiliary emulsifier was the ratio of 5: 1; Microemulsion prescription was water-oleic acid ethyl ester-mixed emulsifier (0.45:0.1:0.45). The optimum extraction process was: time for 12.5 min, temperature of 52 degrees C, power of 360 W, frequency of 400 kHz, and the liquid-solid ratio of 40:1. The extraction rate of curcuminoids was 92.17% and 86.85% in microemulsion and oil phase, respectively. Curcuminoids is soluble in this microemulsion prescription with good extraction rate. This method is simple and suitable for curcuminoids extraction from Curcuma longa rhizome.

Influência de temperatura, luz e giberelina na germinação de sementes de Thlaspi caerulescens J. Presl & C. Presl (Brassicaceae

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Marcelo de Almeida Guimarães

2010-06-01

Full Text Available Thlaspi caerulescens é espécie hiperacumuladora de metais como Cd2+, Ni2+ e Zn2+, considerada como uma plantamodelo para estudar a acumulação e tolerância a metais pesados. No entanto, a baixa produção de sementes em nossas condições climáticas tornam necessária a determinação de condições que possam maximizar a germinação e o vigor de suas sementes. Para identificar as melhores condições para a germinação, sementes de T. caerulescens foram colocadas na presença (15 mmol.m-2.s-1, 8 h luz/16 h escuro ou ausência de luz nas temperaturas de 10, 15, 20 e 25 ºC, em papel germitest previamente umedecido com solução de ácido giberélico (GA3 a 0,05% ou água destilada. Foram avaliados a porcentagem de germinação (%G e o índice de velocidade de germinação (IVG. Maior porcentagem de germinação (66% foi observada nos tratamentos com GA3 e temperaturas de 15 e 20 ºC, na presença de luz. Maiores valores do IVG foram obtidos com a utilização de GA3 nas temperaturas de 15 e 20 ºC, tanto na presença quanto na ausência de luz. Maiores germinação e IVG de T. caerulescens foram observados com uso de GA3 na presença de luz nas temperaturas de 15 e 20 ºC.

Synergistic mosquito-repellent activity of Curcuma longa, Pogostemon heyneanus and Zanthoxylum limonella essential oils.

Science.gov (United States)

Das, N G; Dhiman, Sunil; Talukdar, P K; Rabha, Bipul; Goswami, Diganta; Veer, Vijay

2015-01-01

Mosquito repellents play an important role in preventing man-mosquito contact. In the present study, we evaluated the synergistic mosquito-repellent activity of Curcuma longa, Pogostemon heyneanus and Zanthoxylum limonella essential oils. The mosquito repellent efficacies of three essential oils were evaluated separately and in combination under laboratory and field conditions. N,N-Diethylphenylacetamide (DEPA) and dimethylphthalate (DMP) were used for comparison of the protection time of the mixture of essential oils. At an optimum concentration of 20%, the essential oils of C. longa, Z. limonella and P. heyneanus provided complete protection times (CPTs) of 96.2, 91.4 and 123.4 min, respectively, against Aedes albopictus mosquitoes in the laboratory. The 1:1:2 mixture of the essential oils provided 329.4 and 391.0 min of CPT in the laboratory and field trials, respectively. The percent increases in CPTs for the essential oil mixture were 30 for DMP and 55 for N,N-diethylphenylacetamide (DEPA). The synergistic repellent activity of the essential oils used in the present study might be useful for developing safer alternatives to synthetic repellents for personal protection against mosquitoes. Copyright © 2015 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.

Identificação dos parâmetros de design de dutos de luz solar através do emprego da simulação computacional

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Gandhi Escajadillo Toledo

2013-12-01

Full Text Available Os dutos de luz solar podem reduzir o consumo de energia gasta em iluminação, como também melhorar o conforto visual nos ambientes. Para a previsão do desempenho lumínico destes sistemas, recomenda-se a utilização de simulações computacionais, como o programa Troplux. O presente artigo tem como objetivo determinar os parâmetros de design para os dutos de luz solar através da simulação computacional. O método aplicado neste trabalho foi dividido em duas etapas. Na primeira etapa foi comparado o desempenho luminoso de três modelos virtuais de dutos de luz solar, com características ópticas iguais, mas com geometrias diferentes, visando identificar a geometria de duto mais eficiente. Na segunda etapa foi simulado o desempenho do duto de luz eleito, tendo como referência as especificações da CIE (Comissão Internacional de Iluminação para os tipos de céu e incidência solar. Os resultados das simulações foram então empregados para identificar os principais parâmetros de design para o os dutos de luz solar.

Identificação dos parâmetros de design de dutos de luz solar através do emprego da simulação computacional

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Gandhi Escajadillo Toledo

2013-08-01

Full Text Available Os dutos de luz solar podem reduzir o consumo de energia gasta em iluminação, como também melhorar o conforto visual nos ambientes. Para a previsão do desempenho lumínico destes sistemas, recomenda-se a utilização de simulações computacionais, como o programa Troplux. O presente artigo tem como objetivo determinar os parâmetros de design para os dutos de luz solar através da simulação computacional. O método aplicado neste trabalho foi dividido em duas etapas. Na primeira etapa foi comparado o desempenho luminoso de três modelos virtuais de dutos de luz solar, com características ópticas iguais, mas com geometrias diferentes, visando identificar a geometria de duto mais eficiente. Na segunda etapa foi simulado o desempenho do duto de luz eleito, tendo como referência as especificações da CIE (Comissão Internacional de Iluminação para os tipos de céu e incidência solar. Os resultados das simulações foram então empregados para identificar os principais parâmetros de design para o os dutos de luz solar.

Emisión de luz: espectro de frecuencias y ley del cuadrado de la distancia

OpenAIRE

Miret Marí, Juan José; Caballero Caballero, María Teresa; Pérez Rodríguez, Jorge; Espinosa Tomás, Julián

2009-01-01

Guión de la práctica de laboratorio de Física "EMISIÓN DE LUZ: ESPECTRO DE FRECUENCIAS Y LEY DEL CUADRADO DE LA DISTANCIA" Objetivos: Visualizar y realizar medidas sobre el espectro visible. Comprobar la ley del cuadrado de la distancia.

Perfil cognitivo de idosos residentes em Instituições de Longa Permanência de Brasília-DF

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Luzia Sousa Ferreira

2014-04-01

Full Text Available O envelhecimento expõe os indivíduos a uma série de limitações, como a capacidade física, nutricional e cognitiva, as quais podem leválos a internação em Instituições de Longa Permanência. Neste estudo, objetivou-se avaliar o perfil cognitivo de idosos institucionalizados por meio de três instrumentos. Sessenta idosos institucionalizados em Instituições de Longa Permanência foram submetidos à avaliação dos instrumentos Mini Exame do Estado Mental (MEEM, Teste de Trilha A e a Escala de Demência (CDR. Verificou-se que o percentual de idosos com perda cognitiva por meio do MEEM foi de 30% da amostra, sendo mais prevalente em mulheres (36,2% de perda cognitiva, quando comparado aos homens (7,7% de perda cognitiva. Não houve consistência entre os resultados verificados por meio do MEEM com os demais instrumentos testados.

Development, characterization and cross species amplification of polymorphic microsatellite markers from expressed sequence tags of turmeric (Curcuma longa L.).

Science.gov (United States)

Siju, S; Dhanya, K; Syamkumar, S; Sasikumar, B; Sheeja, T E; Bhat, A I; Parthasarathy, V A

2010-02-01

Expressed sequence tags (ESTs) from turmeric (Curcuma longa L.) were used for the screening of type and frequency of Class I (hypervariable) simple sequence repeats (SSRs). A total of 231 microsatellite repeats were detected from 12,593 EST sequences of turmeric after redundancy elimination. The average density of Class I SSRs accounts to one SSR per 17.96 kb of EST. Mononucleotides were the most abundant class of microsatellite repeat in turmeric ESTs followed by trinucleotides. A robust set of 17 polymorphic EST-SSRs were developed and used for evaluating 20 turmeric accessions. The number of alleles detected ranged from 3 to 8 per loci. The developed markers were also evaluated in 13 related species of C. longa confirming high rate (100%) of cross species transferability. The polymorphic microsatellite markers generated from this study could be used for genetic diversity analysis and resolving the taxonomic confusion prevailing in the genus.

Ultraviolet radiation response of two heterotropy Antarctic marine bacterial; Respuesta a la radiacion ultravioleta de dos cepas bacterianas marinas heterotrofas antarticas

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Hernandez, Edgardo A [Buenos Aires Univ. (Argentina). Facultad de Farmacia y Bioquimica; Ferreyra, Gustavo A; Mac Cormack, Walter P [Direccion Nacional del Antartico, Buenos Aires (Argentina). Instituto Antartico Argentino

2004-07-01

Two Antarctic marine bacterial strains, were exposed to different irradiance of ultraviolet (UV) solar radiation using several experimental protocols and interferential filters. Results showed that both, UV-A and UV-B radiation produce deleterious effects on two tested bacterial strains. The mortality values under UVB treatments were higher than those observed under UVA treatments. UVvi strain proved to be more resistant to UV radiation than the UVps strain. (author) [Spanish] Dos cepas marinas antarticas fueron expuestas a diferentes irradiancias de radiacion solar ultravioleta (UV) utilizando diferentes protocolos experimentales y filtros interferenciales. Los resultados mostraron que tanto la radiacion UV-A como UV-B produce efectos deletereos sobre las dos cepas bacterianas analizadas. Los valores de mortalidad bajo tratamiento UV-B fueron mayores que los observados bajo tratamiento UV-A. La cepa UVvi mostro mayor resistencia a la radiacion UV que la cepa UVps. (autor)

Curcuma longa extract – Haldi: A safe, eco-friendly natural cytoplasmic stain

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Suryawanshi, Hema; Naik, Rupali; Kumar, Pramod; Gupta, Rolly

2017-01-01

Background: Eosin is most widely used synthetic dye belonging to the xanthene group. These dyes are efficient but are hazardous to human and animal health. With the increasing awareness of a green earth, it is advisable to use more of eco-friendly and biodegradable material which can be effectively achieved by the use of natural dyes obtained from plants and other natural sources. Turmeric, available as Curcuma longa (domestic), has long been in use in the subcontinent as a spice and flavoring agent in most food preparations. Its health benefit as a natural antibiotic and anti-inflammatory has been successfully established by several researchers. The intense yellow color imparted by turmeric inspired us to explore its efficacy as a potential alternative for eosin in routine histopathological procedures. Aim: The aim of this was to explore the efficacy of turmeric extract as a stand-alone counterstain for hematoxylin and its comparative assessment with routine H and E staining. Materials and Methods: The rhizomes of C. longa were cut into small pieces, dried and milled. This powder was dissolved into alcohol and centrifuged using a centrifugal machine. The supernatant was then collected with the help of micropipette. This supernatant was used as a counterstain for hematoxylin. Results: The data were analyzed using Mann–Whitney U test with Statistical Package for the Social Sciences version 15.0 (SPSS Inc.,). The P value obtained was statistically insignificant (P > 0.05). Conclusion: Although eosin is the most efficient counterstain for hematoxylin, turmeric can also be used as an alternative for eosin. PMID:29391705

Fatty Acids Composition and Antibacterial Activity of Aristolochia longa L. and Bryonia dioïca Jacq. Growing Wild in Tunisia.

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Dhouioui, Mouna; Boulila, Abdennacer; Jemli, Maroua; Schiets, Fréderic; Casabianca, Hervé; Zina, Mongia Saïd

2016-08-01

The composition of the fatty acids of the roots and aerial parts of Aritolochia longa (Aristolacheae) and Bryonia dioïca (Cucurbutaceae) was analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The oils extracted from the aerial parts of both species were rich in polyunsaturated fatty acids with the essential linolenic and linoleic acids being the most prominent compounds. Oleic and linoleic acids were the majors fatty acids in the roots of both species. Whatever the plant part analyzed and the species, the saturated fatty acids were predominantly composed of palmitic and stearic acids. The antibacterial activity, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the lipid extracts were determined against a panel of five bacterial strains. The results showed that the sensitivity to the lipid extracts was different for the test bacterial strains, and the susceptibility of gram positive bacteria was found to be greater than gram negative bacteria. The antibacterial activity of the root lipid extracts was particularly important against Enterococcus feacium (CMI value of 125 µg/mL; CMB values > 250 µg/mL) and Streptococcus agalactiae (CMI value of 125 µg/mL; CMB values 250 µg/mL for A. longa roots). These results indicate that A. longa and B. dioïca could be considered as good sources of essential fatty acids which can act as natural antibacterial agents.

Curcuma longa polyphenols improve insulin-mediated lipid accumulation and attenuate proinflammatory response of 3T3-L1 adipose cells during oxidative stress through regulation of key adipokines and antioxidant enzymes.

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Septembre-Malaterre, Axelle; Le Sage, Fanny; Hatia, Sarah; Catan, Aurélie; Janci, Laurent; Gonthier, Marie-Paule

2016-07-08

Plant polyphenols may exert beneficial action against obesity-related oxidative stress and inflammation which promote insulin resistance. This study evaluated the effect of polyphenols extracted from French Curcuma longa on 3T3-L1 adipose cells exposed to H2 O2 -mediated oxidative stress. We found that Curcuma longa extract exhibited high amounts of curcuminoids identified as curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which exerted free radical-scavenging activities. Curcuma longa polyphenols improved insulin-mediated lipid accumulation and upregulated peroxisome proliferator-activated receptor-gamma gene expression and adiponectin secretion which decreased in H2 O2 -treated cells. Curcuminoids attenuated H2 O2 -enhanced production of pro-inflammatory molecules such as interleukin-6, tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and nuclear factor κappa B. Moreover, they reduced intracellular levels of reactive oxygen species elevated by H2 O2 and modulated the expression of genes encoding superoxide dismutase and catalase antioxidant enzymes. Collectively, these findings highlight that Curcuma longa polyphenols protect adipose cells against oxidative stress and may improve obesity-related metabolic disorders. © 2016 BioFactors, 42(4):418-430, 2016. © 2016 International Union of Biochemistry and Molecular Biology.

Production of L- and D-lactic acid from waste Curcuma longa biomass through simultaneous saccharification and cofermentation.

Science.gov (United States)

Nguyen, Cuong Mai; Kim, Jin-Seog; Nguyen, Thanh Ngoc; Kim, Seul Ki; Choi, Gyung Ja; Choi, Yong Ho; Jang, Kyoung Soo; Kim, Jin-Cheol

2013-10-01

Simultaneous saccharification and cofermentation (SSCF) of Curcuma longa waste biomass obtained after turmeric extraction to L- and D-lactic acid by Lactobacillus coryniformis and Lactobacillus paracasei, respectively, was investigated. This is a rich, starchy, agro-industrial waste with potential for use in industrial applications. After optimizing the fermentation of the biomass by adjusting nitrogen sources, enzyme compositions, nitrogen concentrations, and raw material concentrations, the SSCF process was conducted in a 7-l jar fermentor at 140 g dried material/L. The maximum lactic acid concentration, average productivity, reducing sugar conversion and lactic acid yield were 97.13 g/L, 2.7 g/L/h, 95.99% and 69.38 g/100 g dried material for L-lactic acid production, respectively and 91.61 g/L, 2.08 g/L/h, 90.53% and 65.43 g/100 g dried material for D-lactic acid production, respectively. The simple and efficient process described in this study could be utilized by C. longa residue-based lactic acid industries without requiring the alteration of plant equipment. Copyright © 2013 Elsevier Ltd. All rights reserved.

Los pigmentos fotosintéticos, algo más que la captación de luz para la fotosíntesis

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Manrique Reol, Esteban

2003-01-01

La luz representa uno de los factores más heterogéneos, espacial y temporalmente, de entre los que afectan a las plantas. La luz, por su naturaleza energética, representa además un factor de riesgo añadido en las plantas que la requieren para el proceso fotosintético. Mientras mantienen unos pigmentos como principales responsables de la absorción energética (clorofilas) también han desarrollado otros mecanismos en los que se ven involucrados pigmentos accesorios para disipar de forma...

DJ Jesus Luz?! Controvérsias, capital subcultural e performance de gosto em uma cena de música eletrônica

OpenAIRE

Pereira de Sá, Simone; Universidade Federal Fluminense; Polivanov, Beatriz; Universidade Federal Fluminense

2015-01-01

O artigo tem como questão central discutir questões de gosto, valor, e disputas simbólicas (Bourdieu; 2008, Thornton;1996; Frith; 1996) de atores de uma cena de música eletrônica brasileira (Straw; 1991). Para tal, focamos nossa análise no caso do modelo Jesus Luz, que namorou Madonna e posteriormente se tornou DJ, suscitando uma série de polêmicas relacionadas à autenticidade de suas performances. O caso de Jesus Luz será tratado como uma controvérsia (Latour; 1994; 2005) que nos permite apr...

Influencia del tipo e intensidad de luz en la formación y multiplicación de embriones somáticos de soya

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Jorge Liusvert Pérez Pérez

2012-07-01

Full Text Available Título en ingles: Influence of light type and intensity on induction and proliferation of somatic embryos in soybean Resumen: La embriogénesis somática representa una alternativa para la regeneración de plantas, sobre la cual influyen diversos factores durante el cultivo in vitro. Entre estos, las condiciones de iluminación durante la formación de embriones somáticos es determinante. Sin embargo, no existen trabajos que refieran el efecto de la luz solar en la formación de embriones somáticos de soya. Este trabajo tuvo como objetivo evaluar el efecto del tipo e intensidad de luz en la formación y multiplicación de embriones somáticos de soya cultivar INCASoy-27. Para ello, cotiledones inmaduros de 3,0-4,0 mm de longitud fueron colocados en medio de cultivo con 40 mg.l-1 de ácido 2,4-diclorofenoxiacético, sacarosa 3% y pH 7,0 en cámaras de crecimiento con luz artificial e intensidades luminosas de 5-10 µmol.m-2.s-1 y 68-73 µmol.m-2.s-1, y en cámaras de crecimiento con luz solar con 50-65µmol.m-2.s-1. El mayor número de cotiledones embriogénicos (95,31 se obtuvo en condiciones de luz artificial con alta intensidad luminosa. La mayor formación de embriones somáticos se obtuvo en luz artificial (9,65 y luz solar (8,45 respectivamente con alta intensidad luminosa. No se encontraron diferencias significativas en la multiplicación de los embriones somáticos, al emplear ambas fuente de luz con alta intensidad luminosa. Esta es la primera referencia sobre formación y multiplicación de embriones somáticos de soya con empleo de luz solar. Palabras clave: Cultivo de tejido; embriogénesis somática; fotoperíodo; Glycine max. Abstract: The somatic embryogenesis represents an alternative for the regeneration of plants, in which influence diverse factors during the cultivation. Among these factors, the conditions of illumination during the induction of somatic embryos are determinant. However, works not exist that refer the effect

Genetic diversity of "Pimenta Longa" genotypes (Piper spp., Piperaceae of the Embrapa Acre germplasm collection

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Lúcia Helena de Oliveira Wadt

2004-01-01

Full Text Available The commonly known Pimenta longa is a commercially valuable natural resource found wild in Acre, Brazil. Specifically, three Piperaceae species with contested taxonomic status were studied, Piper hispidinervum, Piper aduncum, and Piper hispidum, to assesses the inter- and intra-specific genetic relationship of 49 Piper genotypes kept in the Pimenta longa germplasm collection at Embrapa Acre, using sixty six Random Amplified Polymorphic DNA (RAPD markers. The DNA polymorphism level detected was high (96.97%, but the marker frequencies for each species showed polymorphism levels of 79.4% for Piper hispidinervum and 5.3% for P. aduncum. The genetic similarity clustering analysis resulted in three distinct groups corresponding to Piper hispidinervum, Piper aduncum, and Piper hispidum. Four and nine characteristic RAPD markers were identified for P. hispidinervum and P. aduncum, respectively, supporting the existence of two separate species. However, six genotypes collected in Tarauacá county formed a distinct subgroup within the P. hispidinervum group and may be considered as an ecotype of this species or an intermediate between the P. hispidinervum and P. aduncum groups. More extensive sampling of both P. hispidinervum and P. aduncum populations throughout the region are needed to further establish their relation and its implication for breeding efforts.

Adaptation mechanisms of Escherichia Coli to the ultraviolet light I. Isolation of mutants resistant to ultraviolet light; Mecanismos de adaptacion de Escherichia Coli a la luz ultravioleta I. Aislamiento de mutantes resistentes a luz ultravioleta

Energy Technology Data Exchange (ETDEWEB)

Alcantara D, D [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

1995-09-15

The objective of this work is to study the adaptation mechanisms of Escherichia coli to the ultraviolet light of 254 nm (W), a component of the solar light that induces a variety of damages in the DNA of the cells exposed, which should be eliminated in order to avoid its lethal and mutagenic effects. Inside this first report, the results obtained about the resistance to UV radiation of 5 independent populations of Escherichia coli, which were subjected in parallel form to 80 successive exposures of UV light with inserted periods of growth are reported. (Author)

Dietary Capsicum and Curcuma longa oleoresins alter the intestinal microbiome and Necrotic Enteritis Severity in three commercial broiler breeds

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Three commercial broiler breeds were fed from hatch with a diet supplemented with Capsicum and Curcuma longa oleoresins, and co-infected with Eimeria maxima and Clostridium perfringens to induce necrotic enteritis (NE). Pyrotag deep sequencing of bacterial 16S rRNA showed that gut microbiota compos...

Interaction of turmeric (Curcuma longa L.) with beneficial microbes: a review.

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Kumar, Ajay; Singh, Amit Kishore; Kaushik, Manish Singh; Mishra, Surabhi Kirti; Raj, Pratima; Singh, P K; Pandey, K D

2017-12-01

Curcuma longa L., commonly known as turmeric, is a rhizomatous herb of the family Zingiberaceae. It is mostly used as a spice, a coloring agent and broadly used in traditional medicine such as Ayurveda, Unani, etc., Turmeric rhizomes interact with a large numbers of rhizosphere-associated microbial species, and some enter the plant tissue and act as endophytes. Both rhizospheric and endophytic species are directly or indirectly involved in growth promotion and disease management in plants and also play an important role in the modulation of morphological growth, secondary metabolite production, curcumin content, antioxidant properties, etc. The present review focuses on the rhizobacterial and endophytic bacterial and fungal populations associated with the turmeric.

Teorías de la luz y el color en la época de las Luces. De Newton a Goethe

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Pimentel, Juan

2015-10-01

Full Text Available This article opens with a review of Isaac Newton’s theory of light, focusing on the controversial character of his crucial experiment. It then proceeds to examine certain aspects of his legacy in a century that was perhaps more Newtonian than his own optics. We analyse some of the metaphors connected with light and the symbolic role of light as the metaphor for knowledge. The article concludes with Goethe’s colour theory, his challenge to Newtonian theory, and his reinstatement of human beings and the history of science in order to achieve a better understanding not only of light, the eye and chromatic phenomena, but also of scientific activity as a whole.En este artículo comenzamos por revisar la teoría de la luz de Isaac Newton, centrándonos en el carácter controvertido del experimento crucial. Después nos detenemos en algunos aspectos de su legado en un siglo quizás más newtoniano que su propia óptica, analizando algunas metáforas bajo las que fue entendida la luz, así como el papel simbólico de la luz, metáfora del conocimiento por excelencia. Finalmente repasamos la teoría de los colores de Goethe, su impugnación de la óptica newtoniana y su empeño en recuperar al ser humano y la historia de la ciencia para entender mejor no sólo qué son la luz, el ojo o los fenómenos cromáticos, sino la actividad científica en su conjunto.

Detecção de oocistos de Cryptosporidium spp. e cistos de Giardia spp. em amostras de esgoto bruto ou tratado: avaliação crítica dos métodos Detection of Cryptosporidium spp. oocysts and Giardia spp. cysts in raw and effluent wastewater: critical evaluation of methods

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Luciana Urbano dos Santos

2011-06-01

Full Text Available Neste trabalho, avaliou-se a eficiência dos métodos centrífugo-concentração e filtração em membrana, na detecção de oocistos de Cryptosporidium spp. e cistos de Giardia spp. em amostras de esgoto bruto e tratado, provenientes de um sistema de lodos ativados (estação de tratamento de esgoto, Samambaia, Campinas, em São Paulo. As amostras foram coletadas quinzenalmente por dois anos: 53 amostras de esgoto bruto (AFL, 53 de efluente tratado sem desinfecção por luz ultravioleta (EFL e 38 de efluente tratado e desinfetado por luz ultravioleta (EFL+UV. Cistos de Giardia spp. foram encontrados em 90,5% das amostras AFL; em 96,2%, de EFL; e em 94,7%, de EFL+UV. Oocistos de Cryptosporidium spp. foram detectados em 6,4% das amostras AFL e em 2,6 % de EFL+UV. Ambos os métodos mostraram-se eficientes na detecção destes protozoários em todos os tipos de amostras, além de apresentarem baixo custo por análise.In this study, the efficiency of centrifuge-concentration and membrane filtrated methods was evaluated in the detection of Cryptosporidium spp. oocysts and Giardia spp. cysts in raw or treated wastewater samples, from activated sludge systems (ETE - Samambaia, Campinas, in São Paulo. The samples were collected once a fortnight for two years: 53 samples of influent (AFL, 53 samples of treated effluent without ultraviolet disinfection (EFL, and 38 samples of treated effluent with ultraviolet disinfection (EFL+UV. Giardia spp. cysts were found in 90.5% of the AFL samples; in 96.2% of the samples, EFL; and in 94.7%, EFL+UV. Cryptosporidium spp. oocysts were detected in 6.4% of AFL samples and 2.6% of EFL+UV. Both methods showed efficiency when detecting protozoa in all types of samples, besides having low costs by analysis.

Survival and mutant production induced by mutagenic agents in Metarhizium anisopliae Sobrevivência e obtenção de mutantes induzidos por agentes mutagênicos em Metarhizium anisopliae

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V. Kava - Cordeiro

1995-12-01

Full Text Available A wild strain of Metarhizium anisopliae, an entomopathogenic fungus, was submitted to three mutagenic agents: gamma radiation, ultraviolet light and nitrous acid. Survival curves were obtained and mutants were selected using different mutagenic doses which gave 1 to 5% survival. Morphological and auxotrophic mutants were isolated. Morphological mutants were grouped in a class with yellow conidia and other with pale vinaceous conidia as opposed to the green wild type conidia. Auxotrophic mutants had requirements for vitamin and aminoacid biosynthesis. More than 58% of the total auxotrophk mutants required proline/aipnine. Gamma radiation showed to be the most efficient mutagenic agent giving 0.2% of auxotrophk mutants followed by ultraviolet light (0.12% and nitrous acid (0.06%.The conidial colour and auxotrophk mutants isolated until now from M. anisopliae were reviewed.Uma linhagem selvagem do fungo entomopatogênico Metarhizium anisopliae foi submetida à ação de três agentes mutagênicos: radiação gama, luz ultravioleta e ácido nitroso. Curvas de sobrevivência foram obtidas para cada mutagênicos utilizado e mutantes foram selecionados a partir de doses dos mutagênicos que proporcionassem de 1 a 5% de sobrevivência. Mutantes morfológicos para a coloração de conídios e mutantes auxotróficos foram isolados. Mutantes para coloração de conidios foram agrupados em duas classes, uma com conídios amarelos e outra com conídios vinho pálido. Os mutantes auxotróficos obtidos foram deficientes para aminoácidos e vitaminas e mais de 58% deles eram auxotróficos para prolina/argmina. Radiação gama foi o mutagênico mais eficiente com uma porcentagem de obtenção de mulantes auxotróficos de aproximadamente 0,2%, seguido pela luz ultravioleta (0.12% e pelo ácido nitroso (0.06%.Os mulantes morfológicos e auxotróficos obtidos até o momento em Metarhizium anisopliae foram revistos.

Metagenomics of Bacterial Diversity in Villa Luz Caves with Sulfur Water Springs

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Giuseppe D’Auria

2018-01-01

Full Text Available New biotechnology applications require in-depth preliminary studies of biodiversity. The methods of massive sequencing using metagenomics and bioinformatics tools offer us sufficient and reliable knowledge to understand environmental diversity, to know new microorganisms, and to take advantage of their functional genes. Villa Luz caves, in the southern Mexican state of Tabasco, are fed by at least 26 groundwater inlets, containing 300–500 mg L-1 H2S and <0.1 mg L-1 O2. We extracted environmental DNA for metagenomic analysis of collected samples in five selected Villa Luz caves sites, with pH values from 2.5 to 7. Foreign organisms found in this underground ecosystem can oxidize H2S to H2SO4. These include: biovermiculites, a bacterial association that can grow on the rock walls; snottites, that are whitish, viscous biofilms hanging from the rock walls, and sacks or bags of phlegm, which live within the aquatic environment of the springs. Through the emergency food assistance program (TEFAP pyrosequencing, a total of 20,901 readings of amplification products from hypervariable regions V1 and V3 of 16S rRNA bacterial gene in whole and pure metagenomic DNA samples were generated. Seven bacterial phyla were identified. As a result, Proteobacteria was more frequent than Acidobacteria. Finally, acidophilic Proteobacteria was detected in UJAT5 sample

La luz gótica. Paisaje religioso y arquitectónico de la época de las catedrales

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Medina del Río, Juan Manuel

2013-06-01

Full Text Available The history of Gothic architecture has travelled intrinsically close to the searching of the light. The present study gets in the composition of this light so singular that helped, across the colored windows, to catechize people who could not speak, thank you of a visual complete system inserted inside an architectural revolutionary complex, the Gothic cathedral. The knowledge of this light, its composition, adjectives and symbolism, might be an important determining to initiate any restoration in the cathedral’s heritage, trying to be respectful to its essence as a magic way of catechizing.La historia de la arquitectura gótica ha viajado intrínsecamente unida a la búsqueda de la luz. El presente estudio se introduce en la composición de esa luz tan singular que ayudó, a través de las vidrieras coloreadas, a catequizar un pueblo que no sabía hablar, gracias de un sistema visual completo insertado dentro de un complejo arquitectónico revolucionario, la catedral gótica. El conocimiento de esa luz, su composición, cualidades y simbología, debe ser un condicionante inexcusable para afrontar cualquier intervención en el patrimonio catedralicio, en aras de respetar su esencia viva como elemento único de catequización.

Modulation of adipogenesis and glucose uptake by Curcuma longa extract in 3T3L1 and L6 cell lines - An in vitro study

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A. Prathapan

2012-05-01

Full Text Available Objective: To evaluate the effects of ethyl acetate extract of Curcuma longa against modulation of glucose uptake and adipogenesis in cell line models. Methods: We used 3T3L1 and L6 cells to investigate cytotoxicity, glucose uptake with 2-NBDG as probe and adipogenesis. All the analysis was done with flowcytometry. Results: The results showed that the extract did not possess any significant glucose uptake activity but it exhibited significant adipocyte differentiation potential. Conclusions: Ethyl acetate extract of Curcuma longa exhibits significant antiadipogenesis and can be used as an effective drug for the treatment of obesity and other associated complications.

Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa.

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Maehara, Shoji; Ikeda, Michiteru; Haraguchi, Hiroyuki; Kitamura, Chinami; Nagoe, Tetsuro; Ohashi, Kazuyoshi; Shibuya, Hirotaka

2011-01-01

We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5).

Effect of Eucommia ulmoides Oliv., Gynostemma pentaphyllum (Thunb.) Makino, and Curcuma longa L. on Th1- and Th2-cytokine responses and human leukocyte antigen-DR expression in peripheral blood mononuclear cells of septic patients.

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Wu, Huang-Pin; Lin, Yin-Ku

2018-05-10

Many traditional Chinese medicines (TCM), such as Eucommia ulmoides Oliv., Gynostemma pentaphyllum (Thunb.) Makino, and Curcuma longa L., have been reported to have various immune-modulatory effects. To determine the effects of extracts from these three TCM on type 1 T help (Th1)- and Th2-cytokine responses and human leukocyte antigen (HLA)-DR expression in peripheral blood mononuclear cells (PBMCs) obtained from septic patients. Lipopolysaccharide (LPS)-stimulated PBMCs of healthy controls and septic patients were cultured for 48 hs with or without 0.05/0.1 mg/ml of TCM extract. HLA-DR expression in monocytes was detected using flow cytofluorimetry. The interferon [IFN]-γ, tumor necrosis factor [TNF]-α, interleukin (IL)- 2, IL-5, IL-10, and IL-13 levels in supernatants were measured with a human enzyme-linked immunosorbent assay. Treatment with either 0.05 or 0.1 mg/ml of C. longa L. extract significantly restored the percentage of HLA-DR-positive monocytes, which was decreased by LPS in control and patient groups. Treatment with 0.05 or 0.1 mg/ml E. ulmoides Oliv. and C.longa L. extract decreased IL-10 production from LPS-stimulated PBMCs of controls and patients. In patients with sepsis, C. longa L. extract decreased IL-10 production to a greater degree than did E. ulmoides Oliv extract. Although IFN-γ, TNF-α, or IL-13 productions from LPS-stimulated PBMCs were influenced by E. ulmoides Oliv., G. pentaphyllum (Thunb.) Makino, or C. longa L. in control or sepsis groups in this study, only the influence of IL-10 was consistent in both control and sepsis groups. By enhancing monocyte HLA-DR expression and decreasing IL-10 production, C. longa L. might help restore inflammatory responses in septic patients to eradicate pathogens. Copyright © 2018 Elsevier B.V. All rights reserved.

Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model.

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Han, Jong-Min; Lee, Jin-Seok; Kim, Hyeong-Geug; Seol, In-Chan; Im, Hwi-Jin; Cho, Jung-Hyo; Son, Chang-Gue

2015-09-15

The medicinal plants Artemisia iwayomogi and Curcuma longa radix are both used to treat hyperlipidemia in traditional Korean and Chinese medicine. To evaluate the anti-hyperlipidemic effects of the 30% ethanol extracts of A. iwayomogi (AI), C. longa (CL), and the mixture of A. iwayomogi and C. longa (ACE), using a high-fat diet-induced hyperlipidemia model. Six of seven groups of C57BL/6N male mice (i.e., not including the naïve group) were fed a high-fat diet freely for 10 weeks. Of these six groups, five (i.e., not including the control group) were administered a high-fat diet supplemented with AI (100mg/kg), CL (100mg/kg), ACE (50 or 100mg/kg), or Lipitor (20mg/kg). Serum lipid profiles, obesity-related markers, hepatic steatosis, hepatic gene expression, and oxidative stress markers were analyzed. AI, CL, and ACE were associated with significant effects on serum lipid profiles (total cholesterol [TC] and triglyceride), body, liver and peritoneal adipose tissue weights, hepatic lipid accumulation, and oxidative stress biomarkers. ACE at 100mg/kg was associated with significantly greater improvements in serum TC and triglyceride, hepatic triglyceride, epididymal adipocyte size, and oxidative stress biomarkers, compared with AI and CL. AI, CL and ACE normalized lipid synthesis-associated gene expression (peroxisome proliferator-activated receptor gamma, fatty acid synthase, sterol regulatory element-binding transcription factor-1c, and peroxisome proliferator-activated receptor alpha). ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Resistência ao fluxo de gases através das cânulas de intubação de dupla luz

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Lustosa Klaus Carvalho

2002-01-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: As cânulas de dupla luz podem impor resistências distintas ao fluxo. Esta disparidade pode acarretar ventilação pulmonar não homogênea. O objetivo deste trabalho é comparar o padrão resistivo da cânula de intubação de dupla luz 37 FR com o das cânulas convencionais, utilizadas em nosso meio, quando submetidas a fluxos diferentes. MÉTODO: Foram utilizadas cânulas de intubação orotraqueal com diâmetros internos de 7, 7,5, 8 e 8,5 mm e de dupla luz 37 FR. Os fluxos foram gerados e mantidos por aparelho de anestesia. A pressão resistiva gerada nas cânulas foi aferida por um pneumotacógrafo de orifício variável e convertida para sistema digital. As resistências foram obtidas dividindo-se as pressões medidas pelos fluxos empregados. Os dados foram submetidos à análise de variância (ANOVA e comparados pelo teste de Tukey. RESULTADOS: Foram registradas cinco medidas obtidas aleatoriamente. Todas as cânulas estavam abertas para o meio-ambiente. Resistências estão em cmH2O.L-1.s-1. A resistência aumenta de forma linear com elevação do fluxo. A cânula 37 FR dupla luz mostrou padrão resistivo semelhante ao da cânula com diâmetro interno de 7,5 mm. A oclusão dos ramos da sonda 37 FR eleva significativamente a resistência ao fluxo. Os fluxos de 0,1 a 0,2 L.s-1 resultaram em pressões resistivas semelhantes para uma mesma sonda de intubação, exceto para cânula 7 mm ou para a 37 FR com oclusão (p < 0,001. CONCLUSÕES: Os padrões resistivos da cânulas 37 FR e 7,5 mm mostraram-se bastante próximos. A oclusão de algum ramo da sonda de dupla luz eleva significativamente a resistência, mas de modo indistinto entre ambos ramos para fluxos abaixo de 0,5 L.s-1. Os resultados do presente estudo sugerem a redução de fluxos inspiratórios como parâmetro para diminuir a resistência do sistema de ventilação, quando um dos lumens de um tubo de dupla luz for obstruído.

Curcumin profiing and genetic diversity of different accessions of Curcuma longa L.

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Neelam Arya

2016-01-01

Full Text Available Objective: To investigate the genetic diversity and variation in active compound of turmeric rhizomes collected from different niches of Uttarakhand. Methods: Genetic diversity and relationship of Curcuma longa accessions was evaluated by random amplification polymorphism DNA analysis and curcumin profiling was evaluated by high performance liquid chromatography method. Results: The curcumin contents in 20 accessions of turmeric rhizomes were found to be in the range of 0.90% to 3.26%. All accessions were separated into six groups (92% genetic similarity by using 10 decamer oligonucleotide primers for the amplification of genomic DNA. Conclusions: The results indicated the possibility of selecting high quality clones for large scale production.

Cytotoxic active constituents of essential oils of Curcuma longa and Curcuma zanthorrhiza.

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Schmidt, Erich; Ryabchenko, Boris; Wanner, Juergen; Jäger, Walter; Jirovetz, Leopold

2015-01-01

The polar and apolar fractions of Curcuma longa and C. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the HeLa cell line. Actinomycin D and curcumin were used as reference samples, both known for their cytotoxic properties. Amongst all fractions tested, the xanthorrizol fraction (CC50: 26.1 ± 1.9 μM) showed the strongest cytotoxic properties similar to those of curcumin (CC50: 8.1 ± 1.7 μM). Further studies also revealed that the cytotoxic effects of the extracts and pure compounds are caused by apoptosis induction identified by the cleaved form of PARP protein.

Analgesic and antipyretic activity of Curcuma longa rhizome extracts in wister rats

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S. Neha

Full Text Available The study was carried out to ascertain analgesic and antipyretic activities of rhizome extracts of Curcuma longa in Wister rats. Both aqueous and alcoholic extracts at 100 and 200 mg/kg by oral, single dose treatment for seven days revealed significant difference (P<0.05, 0.01 in reaction time in terms of analgesic activity before and after treatments which was comparable to analgin (10 mg/kg b wt. and were ineffective in reversal of brewers yeast induced pyrexia. Solvent yield of these extracts was 20 percent and color dark brown and reddish brown with solid and semisolid consistency respectively. [Vet World 2009; 2(8.000: 304-306

Respostas ecofisiológicas de Cybistax antisyphilitica Mart. (Ipê verde) em função das alterações na intensidade de luz

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Freitas, Fernanda Monteiro de

2016-01-01

Luz apresenta uma ampla variação em ambientes florestais do Bioma Cerrado. Cybistax antisyphilitica (ipê-verde), ocupa fisionomias de cerrado sentido restrito, cerradões, além de áreas alteradas. Objetivou-se nesse trabalho compreender como plantas jovens de C. antisyphilitica, responde morfológica e fisiologicamente às alterações na intensidade de luz. Aos cinco meses de idade, 90 mudas de C. antisyphilitica foram levadas para um fragmento de floresta estacional semidecidual, ...

Isolation and characterization of NBS-LRR- resistance gene candidates in turmeric (Curcuma longa cv. surama).

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Joshi, R K; Mohanty, S; Subudhi, E; Nayak, S

2010-09-08

Turmeric (Curcuma longa), an important asexually reproducing spice crop of the family Zingiberaceae is highly susceptible to bacterial and fungal pathogens. The identification of resistance gene analogs holds great promise for development of resistant turmeric cultivars. Degenerate primers designed based on known resistance genes (R-genes) were used in combinations to elucidate resistance gene analogs from Curcuma longa cultivar surama. The three primers resulted in amplicons with expected sizes of 450-600 bp. The nucleotide sequence of these amplicons was obtained through sequencing; their predicted amino acid sequences compared to each other and to the amino acid sequences of known R-genes revealed significant sequence similarity. The finding of conserved domains, viz., kinase-1a, kinase-2 and hydrophobic motif, provided evidence that the sequences belong to the NBS-LRR class gene family. The presence of tryptophan as the last residue of kinase-2 motif further qualified them to be in the non-TIR-NBS-LRR subfamily of resistance genes. A cluster analysis based on the neighbor-joining method was carried out using Curcuma NBS analogs together with several resistance gene analogs and known R-genes, which classified them into two distinct subclasses, corresponding to clades N3 and N4 of non-TIR-NBS sequences described in plants. The NBS analogs that we isolated can be used as guidelines to eventually isolate numerous R-genes in turmeric.

Synergistic potential of Zingiber officinale and Curcuma longa to ameliorate diabetic-dyslipidemia.

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Hussain, Naveed; Hashmi, Abu-Saeed; Wasim, Muhammad; Akhtar, Tauqeer; Saeed, Shagufta; Ahmad, Toheed

2018-03-01

To find the cure of world's one of the leading morbid and mortal disorders; diabetes mellitus and its most prevalent complication, 'diabetic-dyslipidemia', is one of the leading health challenges of 21st century. The use of phytomedicine is a glimmer of hope in this scenario. Studies of current decade have shown that methanolic extracts of Zingiber officinale and Curcuma longa have highly effective therapeutic potentials against the aforesaid disorders, however, which of the extracts has more potential is still unclear. Furthermore, synergistic effect of the extracts has never been studied. Forty-eight Albino adult rats of either sex were randomly divided into eight groups. A-D groups were containing healthy rats while E-H groups were of induced diabetic-dyslipidemic rats. For forty-two days, rats of each group were given either distilled water or Zingiber officinale methanolic extract (ZOME) or Curcuma longa methanolic extract (CLME) or ZOME+CLME therapies at dose rate of 300mg/100 mL dist. H 2 O/kg body wt/day. FPG and lipid profiles were estimated before and after the trial, and were statistically analyzed by one-way ANOVA along with Post-hoc Tukey's multiple comparison tests. Although, ZOME and CLME significantly (P<0.05) lowered fasting plasma glucose (FPG) levels and controlled lipid profiles in diabetic-dyslipidemic rats; yet, synergistic therapy of both extracts (ZOME+CLME) most significantly (P<0.05) controlled all parameters of diabetic-dyslipidemia (78.00±1.06mg/dL FPG, 62.00±0.58mg/dL TG, 66.50±0.76mg/dL cholesterol, 32.00±0.36mg/dL HDL, 22.43±0.64 mg/dL LDL, and 12.40±0.12mg/dL VLDL). Our findings may be useful to formulate new medicines having multiple potentials to control diabetes mellitus, dyslipidemia, and diabetic-dyslipidemia.

The role of the seed coat in the light sensivity in Raphanus sativus L. cv. redondo gigante seeds O papel do tegumento na sensibilidade à luz em sementes de Raphanus sativus L. cv. redondo gigante

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Maura Lúcia Costa Gonçalves

1997-07-01

Full Text Available The role of the seed coat in the light sensitivity of seeds of Raphanus sativus L. cv. redondo gigante was analysed by germination tests of intact and naked seeds. Far-red light caused high inhibition of seed germination, while under white and red lights low inhibition was found. Naked seeds presented no light sensitivity with high percentage germination under light and darkness. However, incubation of naked seeds in -0.6MPa polyethylene glycol solution resulted in light inhibition as observed in intact seeds. The analysis of the seed coat transmitted light indicated that the filtered light presented the same photoequilibrium of phytochrome when compared to the white light, with a decrease of only 33% in the light irradiance which reaches the embryo.O papel do tegumento sobre a sensibilidade à luz em sementes de Raphanus sativus L. cv. redondo gigante foi analisado por testes de germinação de sementes intactas e nuas. A luz vermelho-extremo inibiu fortemente a germinação, enquanto as luzes branca e vermelha apresentaram baixa inibição. Por outro lado, sementes nuas não apresentaram sensibilidade à luz, com alta porcentagem de germinação tanto na luz como no escuro. Entretanto, a incubação das sementes nuas em condições de estresse em solução de polietilenoglicol a -0,6MPa, resultou em inibição na luz, como observadas em sementes intactas. A análise da luz transmitida pelo tegumento das sementes indicou que a luz filtrada apresenta o mesmo fotoequilíbrio teórico do fitocromo obtido na luz branca, com um decréscimo em apenas 33% da irradiância que atinge o embrião.

Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.

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Katsuyama, Yohei; Kita, Tomoko; Horinouchi, Sueharu

2009-09-03

Curcuminoids are pharmaceutically important compounds isolated from the herb Curcuma longa. Two additional type III polyketide synthases, named CURS2 and CURS3, that are capable of curcuminoid synthesis were identified and characterized. In vitro analysis revealed that CURS2 preferred feruloyl-CoA as a starter substrate and CURS3 preferred both feruloyl-CoA and p-coumaroyl-CoA. These results suggested that CURS2 synthesizes curcumin or demethoxycurcumin and CURS3 synthesizes curcumin, bisdemethoxycurcumin and demethoxycurcumin. The availability of the substrates and the expression levels of the three different enzymes capable of curcuminoid synthesis with different substrate specificities might influence the composition of curcuminoids in the turmeric and in different cultivars.

Extratos de Curcuma longa L. e Kalanchoe brasiliensis Camb. no tratamento local do envenenamento por Bothrops alternatus

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F. V. Fonseca

Full Text Available Este trabalho teve como objetivo a utilização dos extratos aquosos das plantas Curcuma longa e Kalanchoe brasiliensis na terapêutica tópica complementar do envenenamento botrópico experimental em camundongos, visando a antagonização dos efeitos locais (edema, hemorragia e necrose provocados pelo veneno. O experimento mostrou que os melhores resultados foram obtidos com o extrato de Kalanchoe brasiliensis.

Adsorption capacity of Curcuma longa for the removal of basic green 1 dye--equilibrium, kinetics and thermodynamic study.

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Roopavathi, K V; Shanthakumar, S

2016-09-01

In the present study, Curcuma longa (turmeric plant) was used as an adsorbent to remove Basic Green 1 (BG) dye. Batch study was carried out to evaluate the adsorption potential of C. longa and influencing factors such as pH (4-10), adsorbent dose (0.2-5 g l-1), initial dye concentration (50-250 mg l-1) and temperature (30-50°C) on dye removal were analysed. The characterisation of adsorbent was carried out using fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and Brunauer, Emmett and Teller (BET) method. Isotherm models that included Langmuir, Freundlich, Tempkin and Dubinin-Radushkevich, and kinetic models such as pseudo first order, pseudo second-order, Elovich and intraparticle diffusion models were studied. A maximum removal percentage (82.76%) of BG dye from aqueous solution was obtained with optimum conditions of pH 7, 1g l-1 adsorbent dose and 30°C temperature, for 100 mg l-1 initial dye concentration. The equilibrium and kinetic study revealed that the experimental data fitted suitably the Freundlich isotherm and Pseudo second order kinetic model. Thermodynamic analysis proved that adsorption system in this study was spontaneous, feasible and endothermic in nature.

La forma del invernadero contemporáneo y la incidencia de la luz solar

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María Sanz Sánchez

2017-07-01

Full Text Available La incidencia de la luz es uno de los aspectos más importantes en el diseño de un invernadero, debido a su función de recrear en su interior un clima diferente al de la latitud en la que se encuentra. Sin embargo, aunque pueda parecer que éste es el factor determinante en la configuración formal de un invernadero, como en todo edificio, existen otros muchos parámetros a considerar. En este artículo se analizan tres invernaderos de referencia posteriores a la Segunda Guerra Mundial, y se observan los aspectos que, en cada caso, han predominado sobre la que sería la forma ideal en lo que respecta a la incidencia de la luz solar. En el primer invernadero, la cuestión se centrará en la imposición de una forma y sistema estructural concretos, en el segundo, en la composición dinámica del conjunto, y en el tercero, en la integración del invernadero en su emplazamiento. Los tres casos tienen en común el compromiso que presenta su solución entre unos y otros parámetros.

A biomarker model of sublethal genotoxicity (DNA single-strand breaks and adducts) using the sentinel organism Aporrectodea longa in spiked soil

International Nuclear Information System (INIS)

Martin, Francis L.; Piearce, Trevor G.; Hewer, Alan; Phillips, David H.; Semple, Kirk T.

2005-01-01

There is a need to develop risk biomarkers during the remediation of contaminated land. We employed the earthworm, Aporrectodea longa (Ude), to determine whether genotoxicity measures could be applied to this organism's intestinal tissues. Earthworms were added, for 24 h or 7 days, to soil samples spiked with benzo[a]pyrene (B[a]P) and/or lindane. After exposure, intestinal tissues (crop/gizzard or intestine) were removed prior to the measurement in disaggregated cells of DNA single-strand breaks (SSBs) by the alkaline comet assay. Damage was quantified by comet tail length (CTL, μm). B[a]P 24-h exposure induced dose-related increases (P 32 P-postlabelling, showed a two-adduct-spot pattern. This preliminary investigation suggests that earthworm tissues may be incorporated into genotoxicity assays to facilitate hazard identification within terrestrial ecosystems. - Sublethal genotoxicity in the sentinel organism A. longa can be used to monitor the effects of contaminants in soil

Distribution of heavy metals in Lumbricus terrestris, Aporrectodea longa and A. rosea measured by atomic absorption and X-ray fluorescence spectrometry

International Nuclear Information System (INIS)

Andersen, C.; Laursen, J.

1982-01-01

Distribution of Ca, Pb, Cd, Zn, Fe and Mn has been investigated in the earthworm species Lumbricus terrestris, Aporectodea longa and A. rosea by atomic absorption and X-ray fluorescence spectrometry measurements. The material of L. terrestris originated from the garden of the Royal Veterinary and Agricultural University in central Copenhagen. Material of the other two species was sampled in sewage sludge treated plots. It was found that lead and cadmium are accumulated in the gut wall and from here transferred to waste nodules (brown bodies). In L. terrestris more lead was transferred to waste nodules than cadmium. Also large amounts of zinc were accumulated in the gut wall. Analyses of L. terrestris calciferous glands showed that these take part in regulation and excretion of a number of heavy metals. Lead and cadmium content was low in the ventral nerve chord and seminal vesicles. A. longa with poorly developed calciferous glands seems to rely more on waste nodule formation in the ultimate immobilization of lead. (author)

Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus.

Science.gov (United States)

Lu, Pei Shan; Inbaraj, Baskaran Stephen; Chen, Bing Huei

2018-01-01

Curcuminoid from Curcuma longa Linnaeus has been demonstrated to be effective in anti-cancer and anti-inflammation. The objectives of the present study were to prepare curcuminoid dispersion and nanoemulsion from C. longa and determine their oral bioavailabilities in rats. After curcuminoid extraction using 99.5% ethanol, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and curcumin were separated within 10 min by high-performance liquid chromatography using an Eclipse XDB-C18 column (Agilent, Palo Alto, CA, USA) and a gradient mobile phase of 0.1% aqueous formic acid and acetonitrile, with a flow rate of 1 mL min -1 , column temperature of 35 °C and detection wavelength of 425 nm. Curcuminoid nanoemulsion at a particle size of 12.1 nm and encapsulation efficiency 98.8% was prepared using lecithin, Tween 80 and water. A pharmacokinetic study in rats revealed that the parameters including T max , C max , t 1/2 and the area under the curve were higher for curcuminoid nanoemulsions than for curcuminoid dispersion at the same dose employed for gavage administration, whereas, for intravenous injection, an opposite trend was shown. The oral bioavailabilities of BDMC, DMC, curcumin and total curcuminoids in nanoemulsion and dispersion were 34.39 and 4.65%, 39.93 and 5.49%, 47.82 and 9.38%, and 46 and 8.7%, respectively. The results of the present study demonstrate a higher oral bioavailability after incorporation of curcuminoid into nanoemulsion, facilitating its application as a botanic drug. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Anti-apoptotic effects of Curcuma longa L. extract and its curcuminoids against blue light-induced cytotoxicity in A2E-laden human retinal pigment epithelial cells.

Science.gov (United States)

Park, Sang-Il; Lee, Eun Hye; Kim, So Ra; Jang, Young Pyo

2017-03-01

The purpose of the study was to investigate the protective effect of the Curcuma longa L. extract (CLE) and its curcuminoids against blue light-induced cytotoxicity in human retinal pigment epithelial (RPE) cells laded with A2E. A2E has been concerned in age-related macular degeneration (AMD). To perform this study, A2E-accumulated ARPE-19 cells were exposed to blue light to induce cytotoxicity. The cytotoxicity and apoptotic gene expression levels were evaluated using a lactate dehydrogenase (LDH) assay and real-time PCR analysis, respectively. Curcuma longa L. extract was found to exert a protective effect in a dose-dependent manner. At a concentration of 15 μm, curcumin, demethoxycurcumin and bisdemethoxycurcumin exerted significant protective effects against blue light-induced cytotoxicity. Treatment with CLE and curcuminoids meaningfully reduced the mRNA levels of c-Abl and p53, which was known to be augmented in apoptotic RPE cells. Demethoxycurcumin and bisdemethoxycurcumin were found to inhibit p38 expression, which is increased in blue light-irradiated A2E-accumulated RPE cells. Curcuma longa L. extract and its curcuminoids provided significant protection against photooxidative damage and apoptosis in the RPE cells. Our results suggest that curcuminoids may show potential in the treatment of AMD. © 2017 Royal Pharmaceutical Society.

Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes.

Science.gov (United States)

Lekshmi, P C; Arimboor, Ranjith; Indulekha, P S; Menon, A Nirmala

2012-11-01

Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than the reference standard drug acarbose. Drying of rhizomes was found to enhance α-glucosidase (IC₅₀ = 1.32-0.38 μg/ml) and α-amylase (IC₅₀ = 64.7-34.3 μg/ml) inhibitory capacities of volatile oils. Ar-Turmerone, the major volatile component in the rhizome also showed potent α-glucosidase (IC₅₀ = 0.28 μg) and α-amylase (IC₅₀ = 24.5 μg) inhibition.

Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)

OpenAIRE

Akbar, Abdul; Kuanar, Ananya; Joshi, Raj K.; Sandeep, I. S.; Mohanty, Sujata; Naik, Pradeep K.; Mishra, Antaryami; Nayak, Sanghamitra

2016-01-01

The drug yielding potential of turmeric (Curcuma longa L.) is largely due to the presence of phyto-constituent ‘curcumin’. Curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. Lack of requisite high curcumin containing genotypes and variation in the curcumin content of turmeric at different agro climatic regions are the major stumbling blocks in commercial production of turmeric. Curcumin content of turmeric is greatly influe...

INVITRO STUDIES ON THE EFFECT OF CURCUMA LONGA METHANOL EXTRACTS IN COLORECTAL HCT – 116 CELL LINES

OpenAIRE

Madhuri B S , Dinesh Bhaskar , Balasubramanian Sathyamurthy*

2017-01-01

The leaves of Curcuma longa is commonly known as gummy gardenia/cambi gum tree. It is traditional medicinal plant grown in India, have many medicinal and therapeutic properties in diseases such as inflammatory bowel disease, pancreatitis, arthritis, and chronic anterior uveitis. This leaf extracts are found to have antioxidant, chemopreventive agents, anti-inflammatory and anti cancer activities. Curcumin is the active principle which is responsible for anticancer effects. This work was aimed...

Comparación de dos métodos de colecta para Anophelinos (Cebo humano y trampa de luz CDC, durante la época seca y lluviosa, Yurimaguas, Perú 2005.

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Neil Salazar C

2006-04-01

Full Text Available Objetivo: Evaluar la efectividad de dos métodos de colectas para Anofelinos adultos (cebo humano y trampas de luz CDC, en el intra y peridomicilio durante la época lluviosa y seca entre enero a junio de 2005 en una localidad endémica de malaria del distrito de Yurimaguas, Loreto, Perú. Materiales y métodos: Las colectas de los mosquitos adultos con cebo humano y trampas de luz CDC se realizó en cinco barrios: San Juan, Santa Rosa, Central, San Antonio y Florida de la localidad de Munichis, Yurimaguas. Se seleccionaron nueve casas por cada método de colecta. Se estimaron ecuaciones de regresión lineal, cuadrática y cúbica para calcular el número de anofelinos colectados por cebo humano a partir de datos de captura por trampas de luz. Resultados: Se capturó 7790 anofelinos en cebos humanos y 1525 en trampas de luz. Durante toda la evaluación se encontraron nueve especies de Anopheles, siendo las cuatro más abundantes: Anopheles benarrochi Gabaldon, Cova & López, 1941 (85,2%, Anopheles rangeli Gabaldon, Cova & López, 1940 (7,3%, Anopheles konderi Galvao & Damasceno, 1942 (4,0% y Anopheles triannulatus Neiva & Pinto, 1922 (3,1%. La trampa de luz CDC capturó 16,4; 15,3; y 17,1% de anofelinos totales, en el intradomicilio y en el peridomicilio, respectivamente en comparación con los capturados por cebo humano. No existieron diferencias entre la época seca y lluviosa en ninguno de los parámetros evaluados. Conclusiones: Se proponen tres modelos de regresión para estimar el número de anofelinos colectados en cebos humanos intra y peridomiciliarios a partir de trampas de luz CDC.

EFECTO DE LA LUZ Y DEL ÁCIDO GIBERÉLICO (AG3) EN LA GERMINACIÓN DE Minthostachys mollis KUNTH. GRISEB.(LABIATAE) Effect of Light and Giberellic Acid (AG3) on the Germination of Minthostachys mollis Kunth. Griseb. (Labiatae)

OpenAIRE

DIEGO SUÁREZ; JOSÉ LUIS FERNÁNDEZ ALONSO; LUZ MARINA MELGAREJO

2011-01-01

Minthostachys mollis (Kunth) Griseb., es un arbusto perenne que crece en la región andina de Colombia; es ampliamente utilizada por las comunidades rurales donde es valorado por sus propiedades medicinales. El objetivo de este estudio fue determinar el efecto de la luz (luz roja, luz blanca y luz natural) y del ácido giberélico (0, 5, 15, 25 ppm) en el proceso de germinación de M. mollis. Se encontró inhibición de la germinación bajo condiciones de oscuridad. No se observó efecto de AG3 sobre...

Effect of rutin on virus inactivation by AMT in combination with ultraviolet-A irradiation in platelet concentrates

Energy Technology Data Exchange (ETDEWEB)

Yamada, Yoshiko; Abe, Hideki; Ikebuchi, Kenji; Sekiguchi, Sadayoshi [Hokkaido Red Cross Blood Center, Sapporo (Japan)

1999-10-01

Treatment with psoralens and ultraviolet-A (UVA) irradiation have been found to be effective for virus sterilization of platelet concentrates (PCs). We report here a virus inactivation method using a combination of psoralen derivative 4'-aminomethyl-4,5', 8-trimethylpsoralen (AMT) and UVA irradiation (AMT/UVA). Further, we also investigated the effect of rutin, a radical scavenger, on the inactivation of vesicular stomatitis virus (VSV) as a model virus administered in PCs and platelet functions were investigated. Spiked VSV (about 5log{sub 10}) in PCs was inactivated by a combination of AMT (50 {mu}g/ml) and 5.2 J/cm{sup 2} UVA irradiation in the absence of rutin. To obtain equivalent levels of VSV kill in the presence of 0.35 mM rutin, treatment with 13.0 J/cm{sup 2} of UVA irradiation with AMT was performed. When PCs were treated under each condition in which 5log{sub 10} VSV was inactivated by AMT/UVA with or without rutin, platelet aggregation function was maintained for more than 80% of untreated platelets. These findings indicate that the presence of rutin during AMT/UVA treatment conferred no beneficial effect. In addition, overnight storage of PCs with AMT induced 40% loss of platelet aggregation in response to 10{mu}M ADP. The findings suggest that UVA irradiation is required immediately after the addition of AMT. (author)

El xeroderma pigmentoso en su fase de proliferación cutánea tumoral

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Ernesto Melardo Taño Espinosa

2012-03-01

Full Text Available El xeroderma pigmentoso es una enfermedad dermatológica rara, autosómica recesiva, y su etiología está relacionada con el déficit congénito de una endonucleasa que impide la reparación de ADN de las células de la piel que mutan por la incidencia de los rayos ultravioletas. La enfermedad transcurre por 3 etapas clínicas evolutivas y morfológicas. Si no están totalmente protegidos de la luz solar, los enfermos sufren un envejecimiento acelerado de la piel, y desarrollan inevitablemente lesiones oculares y dérmicas que pueden conducir a múltiples lesiones cancerosas. No existe actualmente ningún tratamiento curativo. El diagnóstico precoz y la protección frente a la radiación ultravioleta son los factores imprescindibles en el tratamiento de los pacientes afectados. Se describe la evolución clínica de una niña de 10 años con xeroderma pigmentoso, la cual presenta una fase muy avanzada de la enfermedad, con importante crecimiento de carcinomas cutáneos. El objetivo de la presente publicación es presentar un caso clínico poco frecuente de xeroderma pigmentoso, y al mismo tiempo, realizar una revisión bibliográfica con el fin de orientar el diagnóstico precoz y el tratamiento oportuno en este tipo de casos.

Diseño y fabricación de un sistema electrónico para la caracterización óptica de diodos emisores de luz

OpenAIRE

Fernández Lucas, Jorge

2015-01-01

El propósito de este Trabajo Fin de Grado es el diseño y construcción de un sistema para automatizar la caracterización óptica de diodos emisores de luz. La realización se llevará a cabo mediante un monocromador controlado por una aplicación software que gestiona el movimiento del motor paso a paso, incluido en el monocromador, y un fotodiodo que mide la intensidad de luz que atraviesa el monocromador. Grado en Ingeniería de Tecnologías de Telecomunicación

Esporulação de Pyricularia grisea em diferentes meios de cultura e regimes de luz Sporulation of Pyricularia grisea on different culture media and light regimes

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Maria Fernanda Antunes da Cruz

2009-08-01

Full Text Available Diferentes fatores influenciam o crescimento e a esporulação dos fungos, tais como: composição do meio de cultivo, temperatura e luz. O objetivo do trabalho foi determinar o melhor meio de cultivo e regime de luz para a esporulação de Pyricularia grisea. Um isolado deste, obtido da cultivar de trigo 'BRS 194', foi repicado por disco micelial em oito meios de cultivo (farinha integral de arroz, aveia, centeio, cevada, trigo, triticale; BSA e extrato de tomate e submetido a três regimes de luz (escuro, fotoperíodo de 12h e luz contínua. As placas permaneceram por 10 dias, em câmara de crescimento sob temperatura de 23-25°C. Em seguida, o número de conídios foi determinado em câmara de Neubauer. O meio de cultivo à base de farinha integral de trigo propiciou a maior esporulação do fungo em todos os regimes de luz, e a maior esporulação ocorreu em regime de luz contínua para todos os meios de cultivos testados. Os meios de arroz e BSA propiciaram uma menor produção de conídios pelo fungo.A set of conditions is necessary for the growth and sporulation of fungi, particularly the composition of culture media, temperature and light. The objective of this research was to determine the ideal culture medium and light regime for the sporulation of P. grisea. Micelial discs of an isolate, obtained from cultivar 'BRS 194' of wheat, were transferred to eight culture media (rice wholemeal, oat, rye, barley, wheat, triticale, PSA and tomato sauce and kept in the dark, under continuous light and 12h of light. In a growing chamber, for 10 days at 23-25°C. Then, the number of conidia was determined in a Neubauer chamber. The higher sporulation, regardless of light regime, was observed on wheat wholemeal culture medium. The continuous light provided higher sporulation this fungus in all culture medium. The lowest production of conidia was observed on rice wholemeal and PSA culture media.

Análisis comparativo de dos técnicas para el transporte vertical de la luz natural

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Gerardo Ramírez González

2018-01-01

Full Text Available Este trabajo tiene como objetivo primordial comparar y establecer las relaciones de efectividad entre dos técnicas de diseño para el transporte vertical de la luz natural en el interior de las edificaciones. En primer lugar, se diseñó, construyó y utilizó un equipo experimental tipo concentrador domótico, con distribución a través de fibra óptica hacia un espacio interior sin ninguna iluminación natural tradicional, para monitorizar su efectividad por medio de un luxómetro digital y un recopilador de datos (Datalogger de entrada múltiple. En segundo lugar, se monitorizó el rendimiento lumínico de un lucernario tradicional durante un periodo de seis meses. Finalmente, se realizó un estudio por medio de la Simulación Generada por Computadora (SGC, para establecer la relación entre las proporciones tridimensionales de los ductos de luz y la tasa de degradación de la iluminancia obtenida en el interior del espacio arquitectónico. En términos de resultados, el sistema de iluminación natural por fibra óptica (SINFO no alcanza la efectividad lumínica del lucernario, sin embargo, presenta un rendimiento más uniforme y constante. La idea central es utilizar un criterio de comparación validado, tal como el factor de aprovechamiento de luz diurna (Daylight Factor y otras métricas complementarias, para establecer una relación básica de efectividad entre ambas técnicas. Por último, se establecen recomendaciones de diseño con relación a la utilización de cada una de las técnicas.

Maxwell: la teoría electromagnética de la luz

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Gabàs Masip, Joel

2015-10-01

Full Text Available This article aims to explain the context in which the electromagnetic wave theory was developed and light was identified as an electromagnetic wave. With this aim, it explores Maxwell’s life and times, focusing in particular on the state of knowledge of optics, electricity and magnetism.Este artículo pretende explicar en qué contexto se desarrolló la teoría de las ondas electromagnéticas y se identificó la luz como una de ellas. Para ello se hace un análisis de la figura de Maxwell y su tiempo, haciendo especial hincapié en el estado del conocimiento en óptica, electricidad y magnetismo.

Turmeric (Curcuma Longa: An Underutilized Phytogenic Additive in Poultry Nutrition

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Olumuyiwa Joseph Olarotimi

2018-02-01

Full Text Available The aim of this review paper is to explore the available information from research findings on the use of Turmeric (Curcuma longa as a reliable phytogenic antibiotic for poultry production in the tropics especially in Nigeria and other countries. A wide range of phytogenic additives has found a growing interest in fortification of poultry diets. Supplementation of natural alternatives to antibiotic growth promoters in order to maintain both birds’ performance and health in the tropics will be a welcome development. Turmeric has reportedly been widely supplemented in poultry diets as natural alternative antibiotics in several studies with outstanding performances. The nutritional, medicinal, haematological and phyto-toxicological effects of turmeric were reviewed in this paper. Hence, turmeric supplementation at recommended inclusion rate in poultry feeds without posing any deleterious effects to the birds’ performances as well as the consumers of the products, and ultimately, leading to better profitability on the part of the farmers, will be a nutritional breakthrough for the farmers in the tropics.

Nematicide and nematostatic potential of Curcuma longa on Meloidogyne incognita

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Thaísa Muriel Mioranza

2016-08-01

Full Text Available The root knot nematodes can reduce yield potential of plants, thus requiring searching control methods that are effective and eco-friendly. The purpose of this study was to analyze the efficiency of turmeric rhizome aqueous extract (Curcuma longa on hatching, immobilization and mortality of juveniles of Meloidogyne incognita. A completely randomized design was used, with concentrations of 1%, 5%, 10% and 15% of turmeric extract and distilled water as a control treatment, with four replications. The juveniles of nematodes were directly exposed to turmeric extract for 24 h, while eggs were exposed during 15 days. The turmeric extract on J2 of Meloidogyne incognita, in vitro tests, promoted from the concentration of 10% total paralysis of nematodes and in the concentration of 15% more than 90% mortality. All tested concentrations caused reduction in juveniles hatching. Thereby, the turmeric aqueous extract has nematicidal potential against M. incognita, encouraging its study in the interaction plant-nematode.

Optimization of the extraction of curcumin from Curcuma longa rhizomes

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Viviane P. Paulucci

2012-10-01

Full Text Available The aim of this work was to study the effect of dynamic maceration factors upon the curcumin content of Curcuma longa L., Zingiberaceae, extracts and to determine the optimum set of parameters for the extraction of curcumin using a 2(5 full factorial design and the response surface methodology. Under the established conditions, the content of soluble solids and curcumin in the extracts ranged from 0.8 to 3.4%, and from 0.1 to 1.8%, respectively. The most influential variable observed for the extraction was the ethanolic strength of the solvent. The optimized condition involves an extraction time of 12 h, agitation speed of 30 rpm, drug to solvent ratio of 1/6, extraction temperature of 80 ºC and the solvent with ethanolic strength of 70%. The data reported herein are useful for further developments of curcuma phytopharmaceutical intermediate products with optimized characteristics.

Effect of gamma irradiation on curcuminoids and volatile oils of fresh turmeric ( Curcuma longa)

Science.gov (United States)

Dhanya, R.; Mishra, B. B.; Khaleel, K. M.

2011-11-01

In our earlier study a radiation dose of 5 kGy was reported to be suitable for microbial decontamination and shelf life extension of fresh turmeric ( Curcuma longa), while maintaining its quality attributes. In continuation of that work, the effect of gamma radiation on curcuminoids and volatile oil constituents in fresh turmeric was studied. Fresh peeled turmeric rhizomes were gamma irradiated at doses of 1, 3 and 5 kGy. Curcuminoid content and volatile oils were analyzed by reverse phase HPLC and GC-MS, respectively. The curcuminoid content was slightly increased by gamma irradiation. No statistically significant changes were observed due to irradiation in majority of the volatile oil constituents.

Avaliação da bioatividade dos extratos de cúrcuma (Curcuma longa L., Zingiberaceae em Artemia salina e Biomphalaria glabrata

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Carlos R. M. da Silva Filho

Full Text Available A cúrcuma é o rizoma limpo, em boas condições, seco e moído da Curcuma longa L., uma planta herbácea da família Zingiberaceae. Visando novas alternativas para o controle da esquistossomose, os extratos de Curcuma longa L. foram testados para a avaliação da atividade moluscicida contra caramujos adultos da espécie Biomphalaria glabrata, e toxicidade (ensaio de letalidade com Artemia salina. A oleoresina e o óleo essencial de cúrcuma foram ativos contra Artemia salina (CL50 = 80,43 e CL50 = 319,82 μg/mL, respectivamente e também ativos contra os indivíduos adultos de Biomphalaria glabrata (CL50 = 58,3 e CL50 = 46,73 μg/mL, respectivamente. A partir dos resultados obtidos pôde ser concluído que ambos os extratos podem constituir uma alternativa no controle da população desses caramujos e na redução da esquistossomose.

Highly uniform ultraviolet-A quantum-confined AlGaN nanowire LEDs on metal/silicon with a TaN interlayer

KAUST Repository

Priante, Davide; Janjua, Bilal; Prabaswara, Aditya; Subedi, Ram Chandra; Elafandy, Rami T.; Lopatin, Sergei; Anjum, Dalaver H.; Zhao, Chao; Ng, Tien Khee; Ooi, Boon S.

2017-01-01

In this paper, we describe ultraviolet-A (UV-A) light-emitting diodes (LEDs) emitting at 325 nm based on a highly uniform structure of quantum-confined AlGaN quantum-disk nanowires (NWs). By incorporating a 20 nm TaN interlayer between a Ti pre-orienting layer and the silicon substrate, we eliminated the potential barrier for carrier injection and phonon transport, and inhibited the formation of interfacial silicide that led to device failure. Compared to previous reports on metal substrate, we achieved a 16 × reduction in root-mean-square (RMS) roughness, from 24 nm to 1.6 nm, for the samples with the Ti/TaN metal-bilayer, owing to the effective diffusion barrier characteristic of TaN. This was confirmed using energy dispersive X-ray spectroscopy (EDXS) and electron energy loss spectroscopy (EELS). We achieved a considerable increase in the injection current density (up to 90 A/cm2) compared to our previous studies, and an optical power of 1.9 μW for the 0.5 × 0.5 mm2 NWs-LED. This work provides a feasible pathway for both a reliable and stable UV-A device operation at elevated current injection, and eventually towards low-cost production of UV devices, leveraging on the scalability of silicon substrates.

Highly uniform ultraviolet-A quantum-confined AlGaN nanowire LEDs on metal/silicon with a TaN interlayer

KAUST Repository

Priante, Davide

2017-11-02

In this paper, we describe ultraviolet-A (UV-A) light-emitting diodes (LEDs) emitting at 325 nm based on a highly uniform structure of quantum-confined AlGaN quantum-disk nanowires (NWs). By incorporating a 20 nm TaN interlayer between a Ti pre-orienting layer and the silicon substrate, we eliminated the potential barrier for carrier injection and phonon transport, and inhibited the formation of interfacial silicide that led to device failure. Compared to previous reports on metal substrate, we achieved a 16 × reduction in root-mean-square (RMS) roughness, from 24 nm to 1.6 nm, for the samples with the Ti/TaN metal-bilayer, owing to the effective diffusion barrier characteristic of TaN. This was confirmed using energy dispersive X-ray spectroscopy (EDXS) and electron energy loss spectroscopy (EELS). We achieved a considerable increase in the injection current density (up to 90 A/cm2) compared to our previous studies, and an optical power of 1.9 μW for the 0.5 × 0.5 mm2 NWs-LED. This work provides a feasible pathway for both a reliable and stable UV-A device operation at elevated current injection, and eventually towards low-cost production of UV devices, leveraging on the scalability of silicon substrates.

The effects of combining Artemisia annua and Curcuma longa ethanolic extracts in broilers challenged with infective oocysts of Eimeria acervulina and E. maxima

Science.gov (United States)

Due to an increasing demand for natural products to control coccidiosis in broilers we investigated the effects of supplementing a combination of ethanolic extracts of Artemisia annua and Curcuma longa in drinking water. Three different dosages of this herbal mixture were compared with a negative co...

Contenido fenólico y capacidad antioxidante de fresa mínimamente procesada sometida a tratamientos de conservación por pulsos de luz de alta intensidad

OpenAIRE

Chordi Barrufet, Silvia

2013-01-01

La utilización de tratamientos de luz pulsada es efectiva para la descontaminación de productos vegetales al tener poder antimicrobiano. El tratamiento con pulsos de luz en fresa mínimamente procesada provocó una ligera disminución del contenido de compuestos fenólicos totales, pero no afectó a la capacidad antioxidante ni al contenido de antocianinas totales. El tiempo de almacenamiento y la presencia de antioxidantes produjeron cambios en la composición de los compuestos bioactivos presente...

Effect of concentration of Curcuma longa L. on chitosan-starch based edible coating

Science.gov (United States)

Yusof, N. M.; Jai, J.; Hamzah, F.; Yahya, A.; Pinijsuwan, S.

2017-08-01

The ability of chitosan-starch based coating to extend shelf life of strawberry were studied. The main objectives of this paper is to study the effects of different concentrations (20, 15, 10 and 5 µL) of Curcuma longa L. (CUR) essential oil into chitosan-based edible coating on surface tension in order to increase the effectiveness of the coating. CUR or turmeric is one of the commercially planted herbs in Malaysia for its phytochemical benefits. Application of edible coating using dipping technique has been analysed and evaluated for their effectiveness in extending shelf life of fruits. Surface tension was analysed to investigate the adhesion properties. The best CUR concentration was 15 µL with the optimum surface tension was found to be 31.92 dynes/cm.

β2-agonista de longa duração na doença pulmonar obstrutiva crônica (DPOC

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CAMPOS LUIZ EDUARDO MENDES

2000-01-01

Full Text Available No paciente com DPOC, os β2-agonistas de longa duração são capazes de produzir broncodilatação de intensidade semelhante à dos anticolinérgicos, mas, devido a sua propriedade lipofílica, a ação se prolonga por um período até 12 horas após a sua administração. Estudos comparativos entre salmeterol e formoterol sugerem eqüipotência entre 50mcg de salmeterol e 24 ou 12mcg de formoterol quando este é administrado respectivamente através do aerossol dosimetrado ou turbuhaler. É preciso considerar o tipo de inalador para se estabelecer a eqüipotência entre os dois agentes. Até mesmo pacientes com DPOC e cardiopatia associada podem fazer uso dos β2-agonistas de longa duração com segurança. O salmeterol, por ser agonista parcial, é mais seguro nesses casos de maior risco. A terapia broncodilatadora escalonada na DPOC pode ser revista. Brometo de tiotrópio é um novo anticolinérgico cuja ação pode se prolongar por mais de 1-3 dias e talvez seja o novo broncodilatador mais promissor na DPOC

A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng.

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Fung, Foon Yin; Wong, Wan Hui; Ang, Seng Kok; Koh, Hwee Ling; Kun, Mei Ching; Lee, Lai Heng; Li, Xiaomei; Ng, Heng Joo; Tan, Chuen Wen; Zhao, Yan; Linn, Yeh Ching

2017-08-15

Herbs with "blood-activating" properties by traditional medicine theory often raise concerns for their possible anti-platelet or anticoagulation effects based on reports from in vitro studies. Such herbs have been implicated for bleeding manifestations based on only anecdotal reports. In particular, the combination of such herbs with anti-platelet agents is often empirically advised against despite lack of good clinical evidence. Here we studied 3 commonly used herbal preparations Curcuma longa, Angelica sinensis and Panax ginseng on their respective anti-platelet and anticoagulation effect, alone and in combination with aspirin. This is a randomized, double-blind, placebo-controlled trial involving 25 healthy volunteers for each herbal preparation. Each subject underwent 3 phases comprising of herbal product alone, aspirin alone and aspirin with herbal product, where each phase lasted for 3 weeks with 2 weeks of washout between phases. PT/APTT, platelet function by light transmission aggregometry and thrombin generation assay by calibrated automated thrombogram were measured at baseline and after each phase. Information on adverse reaction including bleeding manifestations was collected after each phase. On the whole there was no clinically relevant impact on platelet and coagulation function. With the exception of 5 of 24 subjects in the Curcuma longa group, 2 of 24 subjects in the Angelica sinensis group and 1 of 23 subjects in the Panax ginseng group who had an inhibition in arachidonic-acid induced platelet aggregation, there was no effect of these 3 herbals products on platelet aggregation by other agonists. Combination of these herbal products with aspirin respectively did not further aggravate platelet inhibition caused by aspirin. None of the herbs impaired PT/APTT or thrombin generation. There was no significant bleeding manifestation. This study on healthy volunteers provides good evidence on the lack of bleeding risks of Curcuma longa, Angelica sinensis

Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus

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Chang HB

2015-08-01

Full Text Available Hong-Bin Chang,1 Bing-Huei Chen1,21Department of Food Science, 2Graduate Institute of Medicine, Fu Jen Catholic University, Taipei, TaiwanAbstract: The objectives of this study were to explore the inhibition mechanism of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus. In addition, human bronchus epithelial cell line BEAS-2B (normal cell was selected for comparison. A high-performance liquid chromatography (HPLC method was developed to separate and quantify the various curcuminoids in C. longa extract, including curcumin (1,714.5 µg/mL, demethoxycurcumin (1,147.4 µg/mL, and bisdemethoxycurcumin (190.2 µg/mL. A high-stability nanoemulsion composed of Tween 80, water, and curcuminoid extract was prepared, with mean particle size being 12.6 nm. The cell cycle was retarded at G2/M for both the curcuminoid extract and nanoemulsion treatments; however, the inhibition pathway may be different. H460 cells were more susceptible to apoptosis than A549 cells for both curcuminoid extract and nanoemulsion treatments. Growth of BEAS-2B remained unaffected for both the curcuminoid extract and nanoemulsion treatments, with a concentration range from 1 to 4 µg/mL. Also, the activities of caspase-3, caspase-8, and caspase-9 followed a dose-dependent increase for both A549 and H460 cells for both the treatments, accompanied by a dose-dependent increase in cytochrome C expression and a dose-dependent decrease in CDK1 expression. Interestingly, a dose-dependent increase in cyclin B expression was shown for A549 cells for both the treatments, while a reversed trend was found for H460 cells. Both mitochondria and death receptor pathways may be responsible for apoptosis of both A549 and H460 cells.Keywords: curcuminoid extract, curcuminoid nanoemulsion, Curcuma longa Linnaeus, lung cancer cell, cell cycle, apoptosis mechanism

A CULTURA DO AÇAFRÃO (Curcuma longa L. EM GOIÁS - CONTRIBUIÇÕES PARA A SUSTENTABILIDADE THE TURMERIC CULTURE (Curcuma longa L. IN GOIÁS - CONTRIBUTIONS TO SUSTAINABILITY

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Alzirene de Vasconcelos Milhomem

2007-09-01

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O açafrão (Curcuma longa L., amplamente utilizado como corante natural e condimento, além de agente terapêutico, é cultivado por pequenos produtores familiares, em Goiás, no município de Mara Rosa. Visando a oferecer subsídios à pesquisa sobre a cultura, o processamento e a qualidade do produto final, este trabalho foi realizado com o objetivo de promover a sustentabilidade e pluriatividade da agricultura familiar no estado. O estudo atesta a importância de se viabilizarem processos alternativos para o manejo da cultura, beneficiamento com qualidade, além de descrever aspectos socio-econômicos da atividade, em uma região caracterizada pela concentração de pobreza.

PALAVRAS-CHAVE: Agricultura familiar; tecnologias; processamento; custos de produção.

Turmeric (Curcuma longa L., widely used as a natural colorific and spice, besides as a therapeutic agent, is cultivated by important group of small family farmers, in Mara Rosa, Goiás, Brazil. In an attempt to offer subsidies to a research project with the crop and product processing, with quality, this research was developed, among the objectives to promote sustainability and pluriactivity of family farms in the Goiás State. The study confirms the importance of alternatives for crop management and processing with quality, besides describing socio-economic aspects of the activity, in a region characterized by concentration of poverty.

Estudos sôbre o complemento: I - Ação das radiações de Roentgen e ultravioleta

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F. Rocha Lagôa

1953-12-01

Full Text Available Foram procedidas verificações experimentais sôbre o complemento de vários animais (cão, coelho, cobaio, homem, cavalo e boi, visando se determinar a sensibilidade dos mesmos às radiações de Roentgen e ultravioleta. Foi verificado que a temperatura constante de + 10° C, os complementos examinados, não apresentam modificações mesmo após terem sofrido a ação de 112.500 r. Outrossim, o mesmo não acontece quando são êles submetidos às radiações ultravioleta, a inativação que então se processa, varia em tempo de acôrdo com o grau de diluição do complemento no momento da irradiação. A seguir, se demonstrou que a fração complementar sensível a essas radiações é a fração albumina termolabil (segundo componente C2. Os complementos, assim, inativados podem readquirir as suas propriedades mediante a adição da fração albumina proveniente de complemento íntegro, não irradiado. A fração regeneradora pode pertencer a complemento de animal da mesma espécie, e, em alguns casos, a espécies diversas. Assim, a fração albumina do complemento de cobaio, se mostrou capaz de regenerar o complemento inativado do próprio cobaio, do homem, do cão e, parcialmente, o do coelho, não sendo, no entanto ,regenerado por frações albumina originárias de complementos de nenhum dos referidos animais. A fração albumina do complemento humano se revelou capaz de regenerar o próprio complemento humano, o do boi e do cavalo, não sendo, no entanto, regenerado pela fração albumina íntegra proveniente de complemento dêsses dois animais.Where realized experimental observations about some animals complements (dogs, rabbits,guines pigs, mens, horses and cows, verificated the action of roentgen radiations and ultraviolet radiations about than. It was found that the studied complements in constant temperature of 10°C, were not destroyed by the roentgen radiations (112.500 r. The same thing did not happen those submited under

Reflexiones sobre el silencio y el lenguaje a la luz de oriente y occidente

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Román López, María Teresa

2012-01-01

Nuestra intención es apuntar hacia un marco de reflexión sobre el papel del silencio y el lenguaje a la luz del pensamiento de Oriente y Occidente. La «Comunidad del lenguaje» se interpone siempre entre nosotros y la «realidad», glosándola, desarrollando todo tipo de filigranas semánticas, filtrándola y modelándola a la medida de las necesidades de una humanidad desfondada y perdida en sus preguntas y respuestas. Nuestra experiencia del mundo y de nosotros mismos es...

DISPERSIÓN DE LUZ POR UNA NANOPARTÍCULA DE PLATA CON FORMA ESFEROIDAL PROLATA

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Alejandro Castellanos Jaramillo

2016-06-01

Full Text Available Usando el método de diferencias finitas en el dominio del tiempo se estudia la incidencia y dispersión de radiación electromagnética de una nanopartícula de plata con forma esferoidal prolata. Se obtiene la distribución de frecuencias del vector de Poynting dispersado en el régimen casi estacionario y se estudia el estado de radiación de la nanopartícula cuando el pulso de luz ha dejado de perturbarla. Los resultados son de interés didáctico

DISPERSIÓN DE LUZ POR UNA NANOPARTÍCULA DE PLATA CON FORMA ESFEROIDAL PROLATA

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Alejandro Castellanos Jaramillo; Arnulfo Castellanos Moreno

2016-01-01

Usando el método de diferencias finitas en el dominio del tiempo se estudia la incidencia y dispersión de radiación electromagnética de una nanopartícula de plata con forma esferoidal prolata. Se obtiene la distribución de frecuencias del vector de Poynting dispersado en el régimen casi estacionario y se estudia el estado de radiación de la nanopartícula cuando el pulso de luz ha dejado de perturbarla. Los resultados son de interés didáctico

Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function.

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Pan, Min-Hsiung; Wu, Jia-Ching; Ho, Chi-Tang; Badmaev, Vladimir

2017-05-12

Background Immunity and Longevity Methods A water extract of Curcuma longa (L.) [vern. Turmeric] roots (TurmericImmune™) standardized for a minimum 20 % of turmeric polysaccharides ukonan A, B, C and D was evaluated for its biological properties in in vitro tissue culture studies. Results The water extract of turmeric (TurP) exhibited induced-nitric oxide (NO) production in RAW264.7 macrophages. These results suggested the immunomodulatory effects of TurP. In addition, the polysaccharides up-regulated function of telomerase reverse transcriptase (TERT) equally to the phenolic compound from turmeric, curcumin. Conclusions The ukonan family of polysaccharides may assist in promoting cellular immune responses, tissue repair and lifespan by enhancing immune response and telomere function.

Componentes de condução da luz natural em edifícios multifamiliares: análise de um código de obras

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Guilherme Nóbrega de Castro

Full Text Available O uso da luz natural como fonte de iluminação, além dos impactos positivos no bem-estar físico e mental do homem, possui vantagens econômicas. Estas, contudo, dependem da obtenção do nível de iluminação requerido para a tarefa. Neste estudo, o potencial de aproveitamento da luz natural foi analisado considerando-se as dimensões mínimas de sistemas de iluminação natural permitidas para ambientes residenciais, tendo como critério o Código de Obras da cidade de João Pessoa. Os sistemas de iluminação natural analisados consistem em componentes de passagem com componentes de condução. Simulação computacional feita com o software Daysim foi adotada para analisar o comportamento da luz natural. Realizaram-se 480 simulações para cinco ambientes, associando três variáveis no componente de condução: peitoril transparente e opaco (i, componente de condução saliente e encravado (ii, cinco profundidades (iii a três variáveis do entorno: máxima ocupação do solo (i, duas alturas de pavimento (ii, quatro orientações (iii. Os parâmetros de análise foram: iluminância natural útil (INU e autonomia da luz natural (ALN. Com os resultados, percebe-se que os limites mínimos dos critérios do Código não favorecem o aproveitamento da iluminação natural: 40% dos modelos simulados apresentam iluminação natural insuficiente. Os ambientes iluminados através de janelas altas têm os piores resultados.

[In vitro antibacterial activity of Curcuma longa (Zingiberaceae) against nosocomial bacteria in Montería, Colombia].

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Méndez Álvarez, Nelson; Angulo Ortíz, Alberto; Contreras Martínez, Orfa

2016-09-01

Bacterial resistance is a growing health problem worldwide that has serious economic and social impacts, compromising public health, and the therapeutic action of current antibiotics. Therefore, the search for new compounds with antimicrobial properties is relevant in modern studies, particularly against bacteria of clinical interest. In the present study, in vitro antibacterial activity of the ethanol extract and essential oil of Curcuma longa (Zingiberaceae) was evaluated against nosocomial bacteria, using the microdilution method. Escherichia coli strains, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus sp. were used, Salmonella sp. and Bacillus sp., isolated from nosocomial infections in a hospital in the city of Monteria and reference strains of S. aureus ATCC 43300, S. aureus ATCC 29213, S. aureus ATCC 25923, P. aeruginosa ATCC 27853, E. coli ATCC 25922 and K. pneumonia ATCC 700603. The ethanol extract antibacterial profile was more efficient at higher concentrations (1 000 ppm), obtaining significant percentages of reduction of more than 50 % against K. pneumoniae ATCC 700603 and a clinical isolate of E. coli; while compared to Bacillus clinical isolate, was more active than the essential oil. For the rest of microorganisms, the reduction percentages obtained at a concentration of 1 000 ppm varied between 17 and 42 % with ethanolic extract, and 8 to 43 % with essential oil. At concentrations of 100 and 500 ppm antibacterial activity of the extracts was lower. The results indicated that the ethanolic extract and essential oil of C. longa rhizomes have active compounds with antibacterial properties that could be used in future research as a therapeutic alternative for the treatment of infections caused by nosocomial pathogens.

Isolation and characterization of bacterial endophytes of Curcuma longa L.

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Kumar, Ajay; Singh, Ritu; Yadav, Akhilesh; Giri, D D; Singh, P K; Pandey, Kapil D

2016-06-01

Fourteen endophytic bacterial isolates were isolated from the rhizome of Curcuma longa L. were characterized on the basis of morphology, biochemical characteristics and 16S rRNA gene sequence analysis. The isolates were identified to six strains namely Bacillus cereus (ECL1), Bacillus thuringiensis (ECL2), Bacillus sp. (ECL3), Bacillus pumilis (ECL4), Pseudomonas putida (ECL5), and Clavibacter michiganensis (ECL6). All the strains produced IAA and solubilized phosphate and only two strains produced siderophore (ECL3 and ECL5) during plant growth promoting trait analysis. All the endophytic strains utilized glucose, sucrose and yeast extract as a carbon source where as glycine, alanine, cystine and glutamine as nitrogen source. The strains were mostly sensitive to antibiotic chloramphenicol followed by erythromycin while resistant to polymixin B. The endophytic strains effectively inhibit the growth of Escherichia coli, Klebsiella pneumoniae and some of the fungal strain like Fusarium solani and Alterneria alternata. The strain ECL2 and ECL4 tolerated maximum 8 % of NaCl concentration where as strains ECL5 and ECL6 6 % in salinity tolerance.

Simultaneous screening of four epidermal growth factor receptor antagonists from Curcuma longa via cell membrane chromatography online coupled with HPLC-MS.

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Sun, Meng; Ma, Wei-na; Guo, Ying; Hu, Zhi-gang; He, Lang-chong

2013-07-01

The epidermal growth factor receptors (EGFRs) are significant targets for screening active compounds. In this work, an analytical method was established for rapid screening, separation, and identification of EGFRs antagonists from Curcuma longa. Human embryonic kidney 293 cells with a steadily high expression of EGFRs were used to prepare the cell membrane stationary phase in a cell membrane chromatography model for screening active compounds. Separation and identification of the retention chromatographic peaks was achieved by HPLC-MS. The active sites, docking extents and inhibitory effects of the active compounds were also demonstrated. The screening result found that ar-turmerone, curcumin, demethoxycurcumin, and bisdemethoxycurcumin from Curcuma longa could be active components in a similar manner to gefitinib. Biological trials showed that all of four compounds can inhibit EGFRs protein secretion and cell growth in a dose-dependent manner, and downregulate the phosphorylation of EGFRs. This analytical method demonstrated fast and effective characteristics for screening, separation and identification of the active compounds from a complex system and should be useful for drug discovery with natural medicinal herbs. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 1: Achillea millefolium-Curcuma longa.

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Calapai, Gioacchino; Miroddi, Marco; Minciullo, Paola L; Caputi, Achille P; Gangemi, Sebastiano; Schmidt, Richard J

2014-07-01

This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 1: Achillea millefolium L.-Curcuma longa L. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

APA/APAGS Award for Distinguished Graduate Student in Professional Psychology: Luz Maria Garcini.

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2016-11-01

The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2016 award winners is Luz Maria Garcini, whose commitment to the health and mental health of those recently immigrated has led to research and service that "have greatly benefited the lives of undocumented individuals in the border area of southern California." Garcini's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress.

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Lee, Hwa-Young; Kim, Seung-Wook; Lee, Geum-Hwa; Choi, Min-Kyung; Chung, Han-Wool; Lee, Yong-Chul; Kim, Hyung-Ryong; Kwon, Ho Jeong; Chae, Han-Jung

2017-07-26

For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl 4 treatment) and chronic-stress (every other day/4week CCl 4 treatment). Compared with acute stress, in which the antioxidant system functioned properly and aspartate transaminase (AST) and ROS production increased, chronic stress increased AST, alanine aminotransferase (ALT), hepatic enzymes, and ROS more significantly, and the antioxidant system became impaired. We also found that ER-originated ROS accumulated in the chronic model, another difference between the two conditions. ER stress was induced consistently, and oxidative intra-ER protein folding status, representatively PDI, was impaired, especially in chronic stress. The PDI-associated client protein hepatic apoB accumulated with the PDI-binding status in chronic stress, and curcumin recovered the altered ER folding status, regulating ER stress and the resultant hepatic dyslipidemia. Throughout this study, curcumin and curcumin-rich Curcuma longa L. extract promoted recovery from CCl 4 -induced hepatic toxicity in both stress conditions. For both stress-associated hepatic dyslipidemia, curcumin and Curcuma longa L. extract might be recommendable to recover liver activity.

Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.

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Kuroda, Minpei; Mimaki, Yoshihiro; Nishiyama, Tozo; Mae, Tatsumasa; Kishida, Hideyuki; Tsukagawa, Misuzu; Takahashi, Kazuma; Kawada, Teruo; Nakagawa, Kaku; Kitahara, Mikio

2005-05-01

The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A(y) mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-gamma ligand-binding activity in a GAL4-PPAR-gamma chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-gamma ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-gamma activation.

Buscando luz en la tierra: bajo las bóvedas del Baño Real del Palacio de Comares

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Miguel Guitart

2015-05-01

Full Text Available A lo largo de la cultura islámica se han producido soluciones espaciales de enorme riqueza arquitectónica y refinamiento estético, que no necesariamente material. El baño o hammam es con probabilidad uno de los más singulares. Procedente de las pautas establecidas por las termas romanas, estos baños se convirtieron en salas fundamentales de la vida social del mundo islámico. Cabría destacar en España ejem­plos tan relevantes como los Baños de Alí en Jaén del siglo X, el Bañuelo del Albaicín en Granada del siglo XI, o el más representativo de todos ellos, el Baño de Comares en el palacio-fortaleza de la Alhambra del siglo XIV. Todos ellos se caracterizan por sus bóvedas perforadas a modo de grandes moldes de luz que, si bien cumplían una misión funcional como la de introducir luz natural y regular la temperatura y la cantidad de vapor de agua en el interior, también transformaban por completo el espacio por medio de la luz y las sombras, haciendo de estas salas lugares muy característicos de su propia cultura. El hammam del Baño del Palacio de Comares, también conocido como Baño Real por haber sido de uso particular de los Reyes Católicos, se remonta a la época de Yusuf I (1333-1354. El Baño Real o de Comares constituye uno de los espacios de mayor interés dentro del conjunto de la Alhambra, con uno de los hammam en mejor estado de conservación hasta la fecha en Occidente, prácticamente íntegro a pesar de algunas modificaciones estructurales y un mantenimiento más testimonial que funcional. Podríamos asumir que el baño del Palacio de Comares se experimenta desde una doble estrategia: la del estatismo del baño como espacio consolidado y no cam­biante, relacionado por su masa y la condición original de la tierra de la que surge y sobre la que se asienta, que se infunde de vida al ser intervenida por la luz esce­nográfica del filtro de sus bóvedas; y la del movimiento establecido, del recorrido del visitante

Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

Science.gov (United States)

Kim, Ji Hye; Kim, Ok-Kyung; Yoon, Ho-Geun; Park, Jeongjin; You, Yanghee; Kim, Kyungmi; Lee, Yoo-Hyun; Choi, Kyung-Chul; Lee, Jeongmin; Jun, Woojin

2016-01-01

Background Even though Curcuma longa L. possesses various biological activities, it has strong flavor and taste, which decrease consumer palatability and limit industrial applications in food. Objective The present study investigates the effects of C. longa L. fermented with Aspergillus oryzae supplementation in 60% high-fat diet-induced obese rats measured by the activation of adipogenesis and lipolysis. Design Rats were divided into four groups (n=6 per group) after 1 week of acclimatization: a normal diet group comprised rats fed the AIN76A rodent diet; a high-fat diet-induced obese group with rats fed a 60% high-fat diet; a Garcinia cambogia treated group (positive control) with rats fed a 60% high-fat diet with G. cambogia 500 g/kg body weight (b.w.)/day; and an fermented C. longa L. 50% ethanolic extract treated group (FCE50) with rats fed a 60% high-fat diet with FCE50 500 g/kg b.w./day. Each group received the appropriate vehicle or sample daily by gastric intubation for 12 weeks. Results We found that FCE50 administration suppressed b.w. gain and reduced white adipose tissue weight, serum triglyceride (TG), and cholesterol in high-fat diet-induced obese rats. These results can be associated with the suppression of adipocyte differentiation and lipogenesis with a decrease in the mRNA expressions of fatty acid synthase, acetyl-CoA carboxylase, adipocyte protein 2, and lipoprotein lipase induced by FCE50 administration. In addition, FCE50 increased lipolysis and β-oxidation by up-regulating the expression of lipases such as adipose triglyceride lipase, hormone-sensitive lipase, adiponectin, and AMP-activated protein kinase. Conclusions These results suggest that FCE50 can be a candidate for the prevention of obesity via suppressing adipogenesis and promoting lipolysis. PMID:26822962

Antibacterial efficacy of Melaleuca alternifolia (Tea tree oil, Curcuma longa (Turmeric, 2% chlorhexidine, and 5% sodium hypochlorite against Enterococcus faecalis: An in vitro study

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Dakshita Joy Sinha

2015-01-01

Full Text Available Aim: To evaluate and compare the antibacterial efficacy of Melaleuca alternifolia (tea tree oil, Curcumalonga (turmeric, 2% chlorhexidine (CHX, and 5% sodium hypochlorite (NaOCl against Enterococcus faecalis. Materials and Methods: Agar plates were prepared using tryptone soya agar. Cultures of E. faecalis were grown in tryptone soya broth. Agar well diffusion method was performed and the plates were incubated at 37΀C for 24 h. The zones of inhibition were recorded. The readings were subjected to statistical analysis using analysis of variance (ANOVA and Tukey′s post hoc test. P-value was considered significant at P < 0.05. Results: Maximum antibacterial efficacy was exhibited by 2% CHX, followed by 5% NaOCl and C. longa with no statistically significant difference between them. It was followed by M. alternifolia (Tea tree oil. Ethanol and saline showed the least antibacterial action. Conclusion: According to the results of this study, C. longa and M. alternifolia can be used as an alternative root canal irrigant, although long-term in vivo studies are warranted.

MECHANISMS OF ACTION OF THE POWDER OF CURCUMA LONGA RHIZOME PLANT ON A CARBOHYDRATE METABOLISM AT ALLOXAN-INDUCED DIABETIC RATS

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R. I. Aizman

2014-01-01

Full Text Available Aim. The effects of the powder of Curcuma longa plant rhizome as food additive on different processes of carbohydrate metabolism: glucose concentration in whole blood, concentration of hormones – insulin and C-peptide in plasma, content of glycogen in the liver, structural and functional organization of the islet apparatus of the pancreas in rats with alloxan-induced diabetes mellitus were studied.Material and methods. The study was conducted on Wistar adult male rats. All animals were divided into 4 groups: 1 and 2 – the controls, 3 and 4 – the rats with alloxan-induced model of diabetes mellitus. Animals of groups 1 and 3 were kept on standard chow, whereas the rats of groups 2 and 4 were feeded with additive of powder from Curcuma longa plant rhizome (2% by weight of feed.The concentration of glucose in blood and perfused solution was determined with picric acid method by intensity of colour reaction on spectrofotometer. Concentration of hormones (insulin, C-peptide was defined by immunoenzyme method with standard sets on tablet spectrofotometer. The morphological structure of a pancreas was studied by a method of light microscopy. Content of glycogen in a liver was measured by means of Shick-reaction on the Mac-Manus method with measurement of colour intensity on spectrofotometer.Results. Intake of the turmeric rhizomes powder by rats with diabetes, as compared with the diabetic animals on a standard diet, resulted in the lower increase of the glucose concentration in blood, the decrease of glucose absorption in the gut, higher concentration of the insulin and C-peptide in plasma and significant increase of glycogen content in the liver. The microstructure of pancreatic tissue samples of experimental animals using turmeric intake, was characterized by the better preservation of the islet apparatus in comparison with a group of animals on a standard diet.Conclusion. The results indicate the positive effect of the Curcuma longa

Características cefalométricas do padrão face longa Cephalometric characteristics assessment of long face pattern

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Mauricio de Almeida Cardoso

2005-04-01

Full Text Available Este estudo determinou as características cefalométricas dos indivíduos portadores de Padrão Face Longa em comparação com indivíduos Padrão I. Um total de 73 telerradiografias em norma lateral, sendo 34 Padrão Face Longa e 39 Padrão I, foram selecionadas com base na morfologia facial, não considerando as relações oclusais e sagitais. Foram avaliados: padrão de crescimento facial, alturas faciais anteriores e posterior, relação maxilo-mandibular, além das relações dentárias com suas bases apicais. De uma forma geral, os indivíduos Padrão Face Longa apresentaram grandes desvios em relação aos indivíduos Padrão I, sendo a doença decorrente de um desequilíbrio entre os componentes verticais. Pôde-se observar que os valores das grandezas AFAT, AFAI, AFATperp, AFAIperp, 1-PP, 6-PP, 1-PM, SNB, ANB, ângulo goníaco, ângulo plano mandibular, além das proporções AFAI/AFAT e AFAIperp/AFATperp, estavam significantemente alterados para os indivíduos Padrão Face Longa. Com base nos resultados obtidos neste estudo, verificou-se que esses indivíduos caracterizavam-se pelo padrão de crescimento vertical e por um aumento da altura facial anterior inferior - conseqüentemente, da altura facial anterior total - estando a deformidade localizada abaixo do plano palatino. Foram observados ainda um retrognatismo maxilar e mandibular, além da presença de extrusão dentária anterior (superior e inferior e póstero-superior, com os incisivos superiores bem posicionados em suas bases e os inferiores lingualizados.This study aimed to determine cephalometric characteristics of long face pattern patients in comparison to Class I pattern patients. A total of 73 lateral norm telerradiographs, 34 long face pattern and 39 Class I pattern individuals, were selected and compared with regards to facial morphology, not considering occlusal and sagital relationships. Additionally, evaluations were also made on facial growth pattern, anterior

Una unidad didáctica centrada en la comprensión de la percepción de la luz y la visión

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Elsa Noemi Meinardi Belluscio

2011-02-01

Full Text Available En nuestra experiencia como docentes hemos detectado que los fenómenos relacionados con la luz y la visión son de difícil comprensión para las y los estudiantes de cualquier nivel educativo. Con el fin de que los alumnos/as puedan responder adecuadamente a la pregunta acerca de cómo vemos, desde un modelo de la luz como rayo, que permita relacionarla con los objetos y el ojo del observador, formulamos una propuesta innovadora de enseñanza que ensayamos con alumnos/as de 12 años (primer año de la Educación Secundaria Básica, en Argentina. La unidad didáctica tiene como objetivo que las y los estudiantes puedan construir explicaciones progresivamente más potentes acerca de los fenómenos que involucran la percepción de la luz y la visión. Para ello, formulamos actividades que buscan dar cuenta de las concepciones alternativas que los alumnos/as poseen al respecto, muchas de las cuales se constituyen en obstáculos a la hora de aproximarse a los modelos científicos. De allí que la secuencia propuesta está centrada en la identificación y la superación de dichos obstáculos, de manera que las y los estudiantes logren considerar inadecuadas las muy frecuentes concepciones acerca de que vemos porque ";;;;;;algo";;;;;; procede del ojo y que los objetos iluminados emiten luz, en vez de reflejarla. La puesta en práctica de esta unidad didáctica promovió la elicitación de las ideas alternativas de los alumnos/as, en tanto que las actividades desarrolladas permitieron ponerlas en discusión, desestabilizarlas y lograr que los modelos científicos presentados cobraran plausibilidad y potencia explicativa, lo que se evidenció a través de la reformulación de las formas argumentativas usadas para dar cuenta de los fenómenos.

Secagem do açafrão (Curcuma longa L. em diferentes cortes geométricos Drying of Curcuma longa L. in different shapes

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Carlos Alberto Almeida Vilela

2008-06-01

Full Text Available O processo de secagem de açafrão, atualmente utilizado pela grande maioria dos produtores agrícolas, consiste na exposição deste produto ao ar livre sobre uma lona plástica estendida sobre o solo, utilizando a radiação solar como fonte de energia para a secagem, sem nenhum tipo de aparato técnico para proteção contra a ação do tempo ou de animais. Sob estas condições de secagem, em um ambiente onde praticamente não há nenhum tipo de controle de temperatura e umidade, surgem vários problemas durante o processo, dentre os quais pode-se destacar o tempo demasiado longo para atingir o ponto final desejado, e paralelamente a isto o desenvolvimento de microrganismos nocivos à saúde e a alta deterioração do produto. Por estar sendo utilizado um ambiente ao ar livre e sem proteção contra a ação do tempo, fica também difícil a previsão do tempo de secagem. Desta forma, o período de secagem pode chegar a 25 dias, o qual é muito longo do ponto de vista industrial. Este trabalho apresenta um levantamento das curvas de secagem do açafrão para diferentes condições de temperatura, velocidade do ar e cortes do rizoma. Tais curvas apresentam a influência da casca, do tipo de corte, da temperatura e da velocidade do ar nos tempos de secagem, parâmetros importantes ao desenvolvimento de novos equipamentos e processos de secagem.The process currently used by most agricultural producers for drying Curcuma longa L. consists in the exposure of the product to atmospheric conditions, on a plastic film on the ground, using solar radiation as energy source for drying, without the use of any kind of apparatus for protection against the weather or animals. Under these drying conditions, in an ambient with practically no temperature and moisture control, various problems can arise, such as an excessively long time to reach desired moisture content, with the concomitant growth of microorganisms harmful to health and high product

Crecimiento y supervivencia de plántulas de cinco especies de Acacia (Fabaceae, que coexisten en bosques secos neotropicales de Argentina, en distintas condiciones de disponibilidad de luz y agua

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Paula Venier

2013-06-01

Full Text Available El establecimiento de la plántula es una de las etapas más riesgosas para las plantas, especialmente en zonas áridas y semiáridas donde la sequía y alta radiación solar influyen sobre su emergencia, desarrollo y supervivencia. Se evaluó en invernadero la supervivencia y variables de crecimiento en plántulas sometidas a estrés hídrico y a distintas condiciones de luz, en cinco especies de Acacia (A. aroma, A. caven, A. atramentaria, A. gilliesii y A. praecox que coexisten en los bosques xerófilos de Córdoba, Argentina. Aunque se encontraron diferencias entre las especies (F=5.66, p=0.001, todas tuvieron altos porcentajes de supervivencia en las distintas condiciones de luz y agua, sugiriendo que serían tolerantes al estrés hídrico y podrían establecerse bajo luz o sombra. Si bien todas las especies mejoraron el crecimiento con luz y sin estrés hídrico, A. aroma, A. caven y A. atramentaria mostraron una tendencia hacia un mayor crecimiento en la mayoría de las variables consideradas (F=41.9, p<0.0001; F=7.06, p<0.0001; F=53.59, p<0.0001. Estos resultados sumados a otros ya reportados indicarían una diferenciación de nichos regenerativos favoreciendo la coexistencia regional de estas especies en los bosques xerófilos de Córdoba.

Antidermatophytic Properties of Ar-Turmerone, Turmeric Oil, and Curcuma longa Preparations.

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Jankasem, Mukda; Wuthi-Udomlert, Mansuang; Gritsanapan, Wandee

2013-01-01

Curcuma longa L. or turmeric of the family Zingiberaceae is widely used in Thai traditional medicines for the treatment of rash, itching, tinea, and ringworm. Previous studies on turmeric oil reported effective antifungal activity against dermatophytes, a group of fungi that causes skin diseases. In this study, turmeric creams containing 6 and 10% w/w turmeric oil were prepared and tested against clinical strains of dermatophytes using broth dilution technique. Minimum fungicidal concentrations of 6 and 10% w/w turmeric creams were found to be 312  μ g/mL. Ar-turmerone, a major compound separated from turmeric oil, promoted more effective antidermatophytic activity with the MICs of 1.56-6.25  μ g/mL, compared to 3.90-7.81  μ g/mL of standard ketoconazole. The results indicated that 6% w/w turmeric oil in the cream was suitable to be formulated as antidermatophytic preparation. Further research should be done on long-term chemical and antifungal stabilities of the preparation.

Efecto del pH, la luz y la concentración de sacarosa en la Embriogénesis somática de cacao (Theobroma cacao L.

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Lisette Valverde Cerdas

2016-03-01

Full Text Available Se llevó a cabo una investigación con el fin de establecer la metodología adecuada para inducir embriogénesis somática en cacao, a partir de semillas maduras. Se estudió el efecto del pH, la luz y la concentración de sacarosa sobre la respuesta embriogénica. Los dos cultivares mostraron diferente respuesta morfogénica y en ambos, estuvo influenciada por el pH, la luz y la concentración de sacarosa. La mejor respuesta embriogénica se obtuvo con un pH de 6,7. El número de embriones producidos fue mayor bajo condiciones de oscuridad que en presencia de luz. La formación de callo y la diferenciación de embriones somáticos estuvo directamente influenciada por la concentración de azúcar en el medio de cultivo. La mayor cantidad de embriones se obtuvo con niveles de sacarosa entre 4% y 6% para el híbrido UF-613xIMC-67 y niveles entre 2% y 4% de sacarosa para el cultivar CATIE-1000. Se presento una embriogénesis somática directa. Los resultados obtenidos sugieren la necesidad de continuar realizando estudios con esta especie.

La Cooperativa de Luz y Fuerza de Río Tercero: una institución al servicio de su comunidad, 1933- 1953

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María Elena Rodríguez

2006-01-01

Full Text Available En nuestro país, las cooperativas eléctricas surgieron a partir de la década de 1920 como reacción popular frente a las elevadas tarifas y al deficiente servicio proporcionado por las empresas de capital extranjero que tenían a su cargo la generación y la distribución de energía. La provincia de Córdoba no fue ajena a este fenómeno, en este artículo nos proponemos mostrar las circunstancias en que surgió la Cooperativa de Luz y Fuerza de Río Tercero en 1933, la que a diferencia de otras de la provincia de Córdoba no generaba la energía que distribuía sino que la compraba a la usina hidráulica del dique Río Tercero, y al mismo tiempo resaltar también su evolución y las repercusiones de su gestión durante las dos primeras décadas de vida en las que prestó el servicio de energía eléctrica y comenzó con las gestiones encaminadas a concretar la provisión de agua corriente a la población de Río Tercero, convirtiéndose en la Cooperativa de Luz y Fuerza y Agua Potable de Río Tercero Limitada inaugurando ese servicio en 1953.In our country, the electric cooperatives appeared in the 1920's decade as a popular reaction against the high bills and deficient service given by the enterprices of abroad capital that were in charge of energy generation and distribution.The Córdoba's province was not indifferent to this phenomenon, in this article we have the purpose to show the circumstances in which have place the Cooperativa de Luz y Fuerza de Río Tercero in 1933, this was different from the others in Córdoba's province because it did not generate the energy that distributed but bought it to the hydraulic usine of Rio Tercero's dock, and at the same time we want to rebound its evolution and the repercussions of its work during its first two decades of life in which it supplied of electric energy and began to negotiate to bring running water to the population of Rio Tercero, inaugurating that service in 1953 and becoming

Aplicación de Dispositivos Móviles en la Medición de los Niveles de Radiación Ultravioleta y su Validación en el Distrito de Chulucanas Región Piura Perú

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Lorena Rubio Rubio

2017-02-01

Full Text Available Se denomina App a una aplicación de software que se instala en dispositivos móviles con la finalidad de facilitar al usuario la consecución de tareas, operaciones o gestiones del día a día. La presente investigación desarrolla un análisis sobre la eficiencia de las aplicaciones móviles en la medición de niveles de radiación ultravioleta en el distrito de Chulucanas, con el objetivo de verificar la confiabilidad de los datos obtenidos y fomentar una cultura de prevención a la sobreexposición solar en la población chulucanense para evitar enfermedades relacionadas a la radiación UV. La metodología empleada considera la información procedente de tres aplicaciones móviles previamente seleccionadas, World UV, Uv-Indeks y NoTeQuemes descargadas gratuitamente. La toma de datos es realizada en tres puntos georreferenciados del distrito de Chulucanas que son, ciudad de Chulucanas, caserío Chapica Campanas y caserío Papelillo, la medición se efectúa cinco veces al día cada dos horas, iniciándose a las 8:00 a.m y culminando a las 4:00 p.m, por un período de un mes. Los resultados obtenidos indican la influencia horaria y diaria sobre el desarrollo del nivel de radiación ultravioleta. En los sectores observados se determina que la hora de mayor impacto ocurre al medio día solar, en cuanto al tipo de aplicación móvil más adecuada se considera a UV Indeks por ser el de mejor respuesta de acuerdo a los resultados obtenidos en la bibliografía consultada.

ANÁLISE DE UMA ORGANIZAÇÃO FAMILIAR À LUZ DO MODELO MULTIDIMENSIONAL-REFLEXIVO

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Isabela Neves Ferraz

2015-10-01

Full Text Available O principal objetivo deste trabalho consiste em analisar, a partir da realização de um estudo de caso, uma organização familiar, tendo como referência o Modelo Multidimensional-Reflexivo de Alves (2003. Todos os característicos retratados no presente artigo, obtidos através da pesquisa documental, entrevistas e observação não-participante, e analisados por meio da técnica de análise de conteúdo, permitiram, como principal achado, o enquadramento da empresa familiar analisada como uma organização, de fato, equiparativo-adaptadora, à luz do modelo formulado por Alves (2003.

Simão José da Luz Soriano e o liberalismo moderado (1858-1860)

OpenAIRE

Silva, Júlio Rodrigues da

2016-01-01

Simão José da Luz Soriano (1802-1891) é principalmente conhecido pelos livros que escreveu sobre a guerra civil de 1828-1834 e a implantação do liberalismo em Portugal. As reflexões po­líticas realizadas em 1858 e em 1860 revelam-nos uma outra faceta da sua obra: a crítica apai­xonada dos erros do regime constitucional. Contudo, as suas observações só podem ser enten­didas se forem relacionadas com o liberalismo moderado da segunda metade do século XIX. O presente artigo pretende fazer a anál...

Análise da ritmicidade circadiana nas transições do horário de verão

OpenAIRE

Guilherme Silva Umemura

2015-01-01

O ciclo claro/escuro gerado pela rotação da Terra tem uma duração razoavelmente regular ao longo ano todo, mas a duração do dia e da noite se altera com o passar das estações, sendo que no inverno a fase clara do dia é mais curta e no verão mais longa e a fase da noite vice-versa. Com o objetivo de tirar um maior proveito da luz solar nos dias mais longos, foi criado o horário de verão, caracterizado pela mudança em uma hora do relógio. Apesar de haver uma suposta economia de energia elétrica...

USO DE GEOTECNOLOGIAS PARA AVALIAÇÃO DE MUDANÇAS NA COBERTURA VEGETAL DO ENTORNO DA ILHA DA LUZ

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Caroline Tavares Firmino

2017-04-01

Full Text Available Os impactos decorrentes da ação antrópica podem ser vistos no solo, nas águas, na flora e na fauna. Como meio de monitorar esses impactos tem sido utilizada técnicas por meio do geoprocessamento, as quais são de suma importância, por fornecerem a possibilidade de monitorar as questões ambientais através de imagens obtidas via sensores orbitais. Objetivou-se analisar as mudanças ocorridas na formação vegetacional do entorno da Ilha da Luz em Cachoeiro de Itapemirim a partir da apreciação de duas imagens do Google Earth. Para a realização da análise temporal as imagens orbitais selecionadas foram importadas do Google Earth para o Autocad, onde foram realizadas as demarcações e medições das formações vegetacionais do entorno da Ilha. Constatou-se um aumento de 1127.0002m² da área vegetacional da Ilha da Luz entre as duas imagens, decorrente da agregação de fragmentos, demonstrando que as ferramentas computacionais são relevantes para avaliação de impactos ambientais.

Influência do tipo de ponteira condutora de luz na microdureza de uma resina composta Influence of the different light-curing TIPS in the microhardness of a composite resin

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Máx Dobrovolski

2010-01-01

Full Text Available O objetivo desta pesquisa foi avaliar a influência do tipo de ponteira condutora de luz na microdureza de uma resina composta micro-híbrida. Foram confeccionados 14 corpos de prova da resina composta Opallis (FGM com dimensões: 5 x 2 mm, divididos em dois grupos de acordo com a ponteira condutora de luz do aparelho fotoativador de lâmpada halógena Optilight Plus - GNATUS/300 mW.cm-2. GI - ponteira condutora de luz de fibra óptica; GII - ponteira condutora de luz de polímero. Após 24 horas, as medidas de microdureza foram efetuadas com um microdurômetro HMV 2000 (Shimadzu Japão. Cinco penetrações foram efetuadas em cada superfície (topo e base totalizando 10 penetrações para cada corpo de prova. A análise estatística dos resultados realizada por meio do teste de ANOVA não apresentou diferenças significativas entre os tipos de ponta condutora de luz nas superfícies avaliadas. A análise estatística demonstrou diferença significativa nos valores médios de microdureza superficial entre as superfícies de topo e de base, para ambas as ponteiras. Com base nos resultados obtidos, foi possível concluir que as ponteiras de luz não interferem na microdureza da resina composta, e que ambas apresentaram diferenças estatisticamente significativas nos valores de microdureza das superfícies topo e base.The aim of this study is to evaluate the influence of the light-curing tips on the microhardness of a micro-hybrid composite resin. Fourteen samples of Opallis (FGM composite resin with 5 x 2 mm were prepared. The specimens were divided into two groups according to the light-curing tips from a halogen light curing unit (Optilight Plus -GNATUS/300 mW.cm-2: GI - optical fiber light-curing; GII - polymer light-curing. After 24 hours, the microhardness measurements were determined using the HMV 2000 (Shimadzu Japan. Five measurements were made on each surface (top and bottom totalizing 10 indentations for each sample. Statistical analysis

Monumento Estela de Luz: disputas en torno a los usos públicos de la historia en el México del Bi/Centenario

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Sebastián Vargas Álvarez

2016-12-01

Full Text Available Este artículo parte de la premisa de que actualmente es imprescindible para los historiadores reconocer la importancia de la vida pública y de los usos públicos de la historia, e involucrarse activamente en los debates sobre la representación del pasado en contextos que exceden la práctica disciplinar y los espacios académicos. Para ello, se propone un caso de estudio concreto: la Estela de Luz, monumento erigido en México, en el 2010, ocasión del Bicentenario de la Independencia y Centenario de la Revolución. Un examen de la historicidad de la Estela –de su planeamiento y ejecución; de sus críticas y resignificaciones–, permite dar cuenta de las maneras en que diversos actores sociales contienden en la arena pública por el sentido de la historia.   Palabras clave: Monumento, Usos públicos de la historia, México, Bi/Centenario, Estela de Luz.

A ESTRUTURA ARGUMENTATIVA E AS CARACTERÍSTICAS DOS ARGUMENTOS NO TEXTO QUE ABORDA A "NOVA TEORIASOBRE LUZ E CORES" DE ISAAC NEWTON

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Fábio Marineli

Full Text Available O presente trabalho busca analisar a estrutura argumentativa e as características dos argumentos que aparecem no texto em que Isaac Newton descreve sua "Nova teoria sobre luz e cores", escrito em 1672. Para tanto, o padrão de Toulmin é utilizado como ferramenta analítica. A identificação da estrutura argumentativa de um texto científico pode ajudar na compreensão da construção do argumento na ciência e servir de apoio à utilização da argumentação na educação científica, inclusive na elaboração de textos didáticos. A análise realizada caracterizou os argumentos apresentados no texto e mostrou como se relacionam na elaboração da explicação de Newton para o fenômeno da formação de cores devido à refração da luz em um prisma.

Structural and Spectral Properties of Curcumin and Metal- Curcumin Complex Derived from Turmeric (Curcuma longa)

Science.gov (United States)

Bich, Vu Thi; Thuy, Nguyen Thi; Binh, Nguyen Thanh; Huong, Nguyen Thi Mai; Yen, Pham Nguyen Dong; Luong, Tran Thanh

Structural and spectral properties of curcumin and metal- curcumin complex derived from turmeric (Curcuma longa) were studied by SEM and vibrational (FTIR and Raman) techniques. By comparison between curcumin commercial, fresh turmeric and a yellow powder obtained via extraction and purification of turmeric, we have found that this insoluble powder in water is curcumin. The yellow compound could complex with certain ion metal and this metal-curcumin coloring complex is water soluble and capable of producing varying hues of the same colors and having antimicrobial, cytotoxicity activities for use in foodstuffs and pharmacy. The result also demonstrates that Micro-Raman spec-troscopy is a valuable non-destructive tool and fast for investigation of a natural plant even when occurring in low concentrations.

Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.

Science.gov (United States)

Kalaycıoğlu, Zeynep; Gazioğlu, Işıl; Erim, F Bedia

2017-12-01

Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity. Antidiabetic activity of curcuminoids was evaluated by their α-glucosidase inhibitory activities. All curcuminoids show activities with decreasing order as BDMC > curcumin > DMC. The significant activities of BDMC compared to its isomers and examination of chemical structures of isomers might be a starting point in designing new drugs for Alzheimer's and Diabetes Mellitus.

El índice ultravioleta en el ámbito laboral: un instrumento educativo Ultraviolet index in the workspace: a learning tool

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Antonio Javier Cortés Aguilera

2011-12-01

Full Text Available Introducción: La exposición a la radiación ultravioleta del sol es un riesgo que sigue sin ser del todo conocido. Este riesgo, al cual está sometida toda la población en general, es especialmente importante para los trabajadores que realizan tareas a la intemperie, ya que a la posible exposición extralaboral (especialmente en los meses de verano se suma una exposición laboral intensa durante muchos meses del año. Esta doble vertiente de exposición al riesgo debe ser tenida en cuenta, por tanto, por los Servicios de Prevención de Riesgos Laborales: desde la perspectiva puramente laboral, a través de las evaluaciones de riesgos y la vigilancia de la salud, y desde la perspectiva extralaboral, a través de campañas / programas de promoción de la salud. Objetivos: Dar a conocer el Índice Ultravioleta (en adelante, IUV como instrumento educativo para la población laboral e integrarlo a nivel individual y colectivo para la adopción de medias preventivas frente a este riesgo dentro y fuera del trabajo. Metodología: Se describen el IUV, los tipos básicos de piel para población europea, el tiempo máximo de exposición solar y el factor de protección solar, para citar las recomendaciones en función del IUV diario, el tipo de piel y el factor de protección. Además, se detallan las medidas para integrar el IUV en la empresa. Conclusiones: El IUV es un instrumento que nos permite llevar el conocimiento y la toma de decisiones basados en él a todos nuestros empleados de una forma clara y sencilla y éstos a su entorno.Introduction: Exposure to ultraviolet radiation (UVR from sunlight is still a risk which is not fully understood. This risk, to which is subject all the general population, is especially important for outdoor workers, because to the possible exposure outside work (especially in summer months we have to add an intense occupational exposure during many months a year. This dual risk of exposure should therefore be taken

APLICACIÓN DE LA ENERGIA SOLAR Y LA LUZ ULTRAVIOLETA EN LA POTABILIZACION DEL AGUA EN ESCUELAS PRIMARIAS

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Antonio Sarmiento Sera

2011-02-01

Full Text Available En un reporte anterior, se expusieron resultados de la aplicación de la energía solar fotovoltaica y la luzultravioleta para la desinfección del agua en el ámbito de experimentos de laboratorio.En el presente informe se presentan características energéticas solares vinculadas con la captación deenergía por los paneles fotovoltaicos y relacionadas con las facilidades energéticas que poseen lasescuelas primarias rurales en Cuba.También se reportan los resultados de la primera etapa experimental en condiciones naturales de tresescuelas primarias rurales del Municipio de Consolación del Sur, Pinar del Río, en la desinfección delagua que utilizan los alumnos para el consumo directo.Los resultados expuestos reflejan el comportamiento satisfactorio del método utilizado, así como susposibilidades para la proyección o generalización en todo el municipio.  In a previous report, results of the application of the photovoltaic solar energy and ultravioletlight were showed for laboratory disinfecting water experiments.In this paper, solar energy characteristics are presented linked with the energy reception by thephotovoltaic panels and related with the energy facilities that the rural primary schools have inCuba.The results of the first experimental stage are also reported under natural conditions of threerural primary schools of the Municipality of Consolación del Sur, Pinar del Río, in the waterdisinfection of the water that the students use for the direct consumption.The exposed results reflect the satisfactory behavior of the utilized method, as well as theirpossibilities for the projection or generalization in the whole municipality.

The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice.

Science.gov (United States)

Eun, Cheong-Su; Lim, Jong-Soon; Lee, Jihye; Lee, Sam-Pin; Yang, Seun-Ah

2017-07-17

Curcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented C. longa (FCL) has not been reported. Therefore, in this study, the effectiveness of FCL for the regulation of memory dysfunction was investigated in two brain cell lines (rat glioma C6 and murine microglia BV2) and scopolamine-treated mice. C. longa powder was fermented by 5% Lactobacillus plantarum K154 containing 2% (w/v) yeast extract at 30 °C for 72 h followed by sterilization at 121 °C for 15 min. The protective effects of fermented C. longa (FCL) on oxidative stress induced cell death were analyzed by MTT assay in C6 cells. The anti-inflammatory effects of FCL were investigated by measuring the production of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) as well as the expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated BV2 cells. The step-through passive avoidance test, Morris water maze test, acetylcholinesterase (AChE) activity, and expression of cAMP response element-binding protein (CREB) and brain-derived neurotropic factor (BDNF) were employed to determine the effects of FCL on scopolamine-induced memory deficit in mice. The contents of curcuminoids were analyzed through LC/MS. Pretreatment with FCL effectively prevented the cell death induced by oxidative stress in C6 cells. Moreover, FCL inhibited the production NO and PGE 2 via the inhibition of iNOS and COX-2 expression in BV2 cells. FCL significantly attenuated scopolamine-induced memory impairment in mice and prevented scopolamine-induced AChE activity in the hippocampus. Additionally, FCL reversed the reduction of CREB and BDNF expression. The curcuminoids content in FCL was 1.44%. FCL pretreatment could alleviate scopolamine-induced memory impairment in mice, as well as oxidative stress and inflammation in C6 and BV2 cells, respectively. Thus, FCL might be a

Antioxidant Properties of Popular Turmeric (Curcuma longa Varieties from Bangladesh

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E. M. Tanvir

2017-01-01

Full Text Available We investigated the aqueous and ethanolic extracts of different forms (local names: mura and chora of turmeric (Curcuma longa from the Khulna and Chittagong divisions of Bangladesh for their antioxidant properties and polyphenol, flavonoid, tannin, and ascorbic acid contents. The antioxidant activity was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH free radical-scavenging activity and ferric reducing antioxidant power (FRAP values. The ethanolic extract of Chittagong’s mura contained the highest concentrations of polyphenols (16.07%, flavonoids (9.66%, and ascorbic acid (0.09 mg/100 g and chora resulted in high yields (17.39%. The ethanolic extract of Khulna’s mura showed a higher DPPH radical-scavenging activity with the lowest 50% inhibitory concentration (IC50 (1.08 μg/mL, while Khulna’s chora had the highest FRAP value (4204.46±74.48 μM Fe [II] per 100 g. Overall, the ethanolic extract had higher antioxidant properties than those in the aqueous extract. However, the tannin concentration was lower in the ethanolic extract. We conclude that the turmeric varieties investigated in this study are useful sources of natural antioxidants, which confer significant protection against free radical damage.

Nanoparticles containing curcuminoids (Curcuma longa: development of topical delivery formulation

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Cristina M. Zamarioli

Full Text Available Solid lipid nanoparticles incorporating Curcuma longa L., Zingiberaceae, curcuminoids were produced by the hot melt emulsion method. A Box–Behnken factorial design was adopted to study the nanoparticles production at different levels of factors such as the percentage of curcuminoids, time of homogenization and surfactant ratio. The optimized nanoparticles were incorporated into hydrogels for stability, drug release and skin permeation tests. The average nanoparticle sizes were 210.4 nm; the zeta potential of −30.40 ± 4.16; the polydispersivity was 0.222 ± 0.125. The average encapsulation efficiency of curcumin and curcuminoids was 52.92 ± 5.41% and 48.39 ± 6.62%, respectively. Solid lipid nanocapsules were obtained with curcumin load varying from 14.2 to 33.6% and total curcuminoids load as high as 47.7%. The topical formulation containing SLN-Curcuminoids showed good spreadability and stability when subjected to mechanical stress test remained with characteristic color, showed no phase separation and no significant change in pH. As a result of slow release, the nanoparticles were able to avoid permeation or penetration in the pig ear epidermis/dermis during 18 h. The topical formulation is stable and can be used in further in vivo studies for the treatment of inflammatory reactions, in special for radiodermitis.

DIFFERENTIATION OF Curcuma longa, Curcuma xanthorrhiza and Zingiber cassumunar BY THIN LAYER CHROMATOGRAPHY FINGERPRINT ANALYSIS

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Mohamad Rafi

2011-07-01

Full Text Available Turmeric (Curcuma longa, java turmeric (Curcuma xanthorrhiza and cassumunar ginger (Zingiber cassumunar are widely used in traditional Indonesian medicine. These three herbs have relatively similar rhizomes colour so it is difficult to be differentiated especially if they are in powder form. A rapid and reliable method, thin layer chromatography (TLC fingerprint, has been developed in order to identify, authenticate and differentiate these three herbs through fingerprint profile of chemical compounds. TLC fingerprints of the three herbs were obtained by visualization of separate zones with visible and UV (254 and 366 nm light. The TLC fingerprint pattern is different each other and showed a specific marker zones respectively. Therefore, TLC fingerprint can be utilized for identification, authentication and differentiation method in quality control of the three herbs tested.

Magnetic purification of curcumin from Curcuma longa rhizome by novel naked maghemite nanoparticles.

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Magro, Massimiliano; Campos, Rene; Baratella, Davide; Ferreira, Maria Izabela; Bonaiuto, Emanuela; Corraducci, Vittorino; Uliana, Maíra Rodrigues; Lima, Giuseppina Pace Pereira; Santagata, Silvia; Sambo, Paolo; Vianello, Fabio

2015-01-28

Naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (SAMNs), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification processes for biomolecules in complex matrices. Polyphenolic molecules presenting functionalities with different proclivities toward iron chelation were studied as probes for testing SAMN suitability for magnetic purification. Thus, the binding efficiency and reversibility on SAMNs of phenolic compounds of interest in the pharmaceutical and food industries, namely, catechin, tyrosine, hydroxytyrosine, ferulic acid, coumaric acid, rosmarinic acid, naringenin, curcumin, and cyanidin-3-glucoside, were evaluated. Curcumin emerged as an elective compound, suitable for magnetic purification by SAMNs from complex matrices. A combination of curcumin, demethoxycurcumin, and bis-demethoxycurcumin was recovered by a single magnetic purification step from extracts of Curcuma longa rhizomes, with a purity >98% and a purification yield of 45%, curcumin being >80% of the total purified curcuminoids.

Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011.

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Solange Missagia Matos

2013-03-01

Full Text Available DISSERTAÇÃO DE MESTRADOMATTOS, Solange Missagia. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011. 115 folhas. Dissertação (Mestrado – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

Efecto de la radiación ultravioleta y la colonización micorrízica en árboles pioneros de la región oriental de América del Norte

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Nilsen Lasso-Rivas

2015-03-01

Full Text Available Las plantas están expuestas a múltiples factores de estrés que causan alteraciones en su fisiología. Sin embargo, la evidencia sugiere que lasrelaciones mutualistas con microorganismos pueden ayudar a las plantas a superar los efectos perjudiciales de algunos factores de estrés abiótico.El objetivo de esta investigación fue analizar los efectos individuales e interactivos de los rayos ultravioleta (UV (280-400 nm y la simbiosis micorrizíca arbuscular (MA en el crecimiento vegetativo en plántulas de tres especies de árboles pioneros. Se cultivaron en invernadero plántulas de Populusdeltoides, Betula nigra y Salix nigra usando un diseño factorial 2 × 2, con dos condiciones de radiación UV (con y sin radiación UV y dos tratamientosMA (inóculo MA vivo o inóculo MA previamente autoclavado. Después de tres meses, las plantas se cosecharon y se registraron crecimiento, morfología y asignación de biomasa; se evaluó porcentaje de colonización MA mediante técnica de cuadricula. Se encontró que las plántulas expuestasa la radiación UV tenían menor peso seco de la raíz, diámetro del tallo, y relación raíz parte aérea (R/A, y mayor área foliar específica (AFEy razón de área foliar (RAF que aquellas plantas cultivadas en ausencia de radiación UV. La colonización MA no evidenció aumento en el crecimientode las plantas. La radiación ultravioleta redujo el porcentaje de raíz colonizada por hongos MA en plántulas de P. deltoides y S. nigra. Se evidencióque niveles ambientales de radiación UV pueden ejercer un efecto indirecto sobre la micorrización MA en plántulas de árboles pioneros.

Influence of blue light spectrum filter on short-wavelength and standard automated perimetries Influência de filtro para o espectro azul da luz na perimetria computadorizada branco-branco e azul-amarelo

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Leonardo Cunha Castro

2006-10-01

Full Text Available PURPOSE: To evaluate the influence of a blue light spectrum filter (BLSF, similar in light spectrum transmittance to the intraocular lens Acrysof NaturalTM, on standard automated perimetry (SAP and short-wavelength automated perimetry (SWAP. METHODS: Twenty young individuals (OBJETIVO: Avaliar a influência de um filtro para o espectro azul da luz, semelhante à lente intra-ocular Acrysof Natural®, nos exames de perimetria automatizada padrão (branco-no-branco e de comprimento de onda curto (azul-no-amarelo. MÉTODOS: Vinte pacientes jovens sem alterações oculares (20 olhos realizaram seqüência de 4 exames de campo visual: perimetria automatizada padrão e azul-no-amarelo com e sem o filtro para o espectro azul da luz. Os índices de limiar foveal (FT, desvio médio (MD e desvio-padrão (PSD obtidos em todos os exames e a diferença causada pela excentricidade nos exames de perimetria automatizada azul-no-amarelo foram analisados. Variabilidade interindivíduos (desvio-padrão dos pontos testados foi calculada. RESULTADOS: Observou-se redução estatisticamente significante no desvio médio (p<0.001 e no limiar foveal (p<0.001 medidos pela perimetria automatizada azul-no-amarelo com o uso do filtro para o espectro azul da luz comparado quando realizado sem o filtro. Nenhum outro índice avaliado apresentou diferença estatisticamente significante nos exames de perimetria automatizada padrão ou azul-no-amarelo. Foi notado aumento da variabilidade interindivíduos com a excentricidade nos exames de perimetria automatizada azul-no-amarelo com e sem o uso do filtro para o espectro azul da luz, assim como a diferença de sensibilidade entre os hemisférios inferior e superior (hemisfério inferior menos superior, mas não houve diferença estatisticamente significante quando comparados os exames com e sem o uso do filtro. Quando foram comparados os 4 pontos mais inferiores e os 4 pontos mais superiores, a diferença inferior-superior aumentou

Anti-giardial therapeutic potential of dichloromethane extracts of Zingiber officinale and Curcuma longa in vitro and in vivo.

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Dyab, Ahmad K; Yones, Doaa A; Ibraheim, Zedan Z; Hassan, Tasneem M

2016-07-01

Giardiosis is one of the common parasitic diarrhoea in humans, especially in children, worldwide. Many drugs are used for its treatment, but there is evidence of drug resistance, insufficient efficacy and unpleasant side effects. Natural products are good candidates for discovering more effective anti-giardial compounds. This study evaluated the activity of extracts of Zingiber officinale (ginger) and Curcuma longa (curcumin) against Giardia lamblia in vitro and in vivo. Giardia cyst suspension was prepared from children faecal specimens. For the in vitro experiment, 1, 10 and 50 mg⁄mL dichloromethane extracts of ginger and curcumin separately were incubated with Giardia cysts for 5, 10, 30 and 60 min. The viability was distinguished by 0.1 % eosin and a haemocytometer. For the in vivo experiments, Balb/c mice were infected with Giardia cyst suspension containing 10,000 cysts/mL. Infected mice were administered 10 and 20 mg kg(-1) day(-1) ginger and curcumin extracts separately for 7 days post-infection. The effectiveness of the extracts was evaluated by faecal cyst and intestinal trophozoite counts and histopathological examination of the small intestine. In vitro ginger extract had a higher significant effect on cyst viability than curcumin, in a dose- and time-dependent manner. In vivo ginger (more effective) and curcumin extracts significantly treated infected mice, and this was evidenced by the faecal cyst and intestinal trophozoite counts reduction, in addition to evident improvement of intestinal mucosal damages induced by Giardia infection. Z. officinale and C. longa extracts may represent effective and natural therapeutic alternatives with low side effects and without drug resistance in the treatment of giardiosis.

Stability indicating HPLC-UV method for detection of curcumin in Curcuma longa extract and emulsion formulation.

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Syed, Haroon Khalid; Liew, Kai Bin; Loh, Gabriel Onn Kit; Peh, Kok Khiang

2015-03-01

A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma longa extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K'), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N>6500, Tcurcumin were ⩽0.87% and ⩽2.0%, while the inter-day precision and accuracy values were ⩽2.1% and ⩽-1.92. Curcumin degraded in emulsion under acid, alkali and UV light. In conclusion, the stability-indicating method could be employed to determine curcumin in bulk and emulsions. Copyright © 2014 Elsevier Ltd. All rights reserved.

Espectrofotometria de lentes oftálmicas filtrantes coloridas sob radiação ultravioleta a e luz visível Spectrophotometry of ophthalmic filtering color lenses under ultraviolet radiation and visible light

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Luís Felipe Fornaciari Ramos

2003-06-01

Full Text Available OBJETIVO: Determinar a transmitância das lentes oftálmicas filtrantes coloridas submetidas à radiação UV A e luz visível e comparar seus resultados na faixa de comprimento de onda compreendida entre 320 e 800 nanômetros (nm. MÉTODOS: Análise espectrofotométrica das lentes filtrantes amarela 1, laranja, verde e fumê da marca "Danny" e amarela 2 da marca "Rio de Janeiro", disponíveis em nosso meio, utilizando-se espectrofotômetro Modelo 6.400, marca JEM Way. RESULTADOS: Todas as lentes estudadas apresentaram padrões de transmitância bastante individualizados, com curvas variáveis para os diversos comprimentos de onda. Na faixa es- pectrofotométrica de 320 a 400 nm, todas as lentes apresentaram transmitância inferior a 4% sendo que a lente amarela 1 apresentou a maior média (3,7 % ao passo que a fumê apresentou a menor média 0,45%. Contudo não foi observado uma diferença estatisticamente significativa entre estas lentes; a lente amarela 2 mostrou melhor proteção em comparação à lente amarela 1 e a laranja. Na análise espectrofotométrica realizada em diferentes posições da mesma lente constatou-se diversidade na curva de variância, apesar de não demonstrar diferença estatisticamente significativa. CONCLUSÕES: Para se indicar um filtro com segurança, as propriedades espectrais do filtro devem ser determinadas pela análise espectrofotométrica. É mais importante a capacidade de filtrar radiações luminosas do que somente ser colorido ou não.PURPOSE: Determination of transmittance curves through spetrophotometric measurementes of color filtering lenses submitted to UVA and light visible radiation, and comparison of the results in the band between 320 and 800 nanometres (nm. METHODS: The filtering color of Danny yellow 1, orange, green and grey and Rio de Janeiro yellow 2 lenses have been analyzed using JEM Way model 6.400 spectrophotometer. RESULTS: All lenses showed distinct and variable transmittance in the

Radiación ultravioleta. Análisis de su comportamiento estacional en diferentes sectores de la región Piura. Costa Norte del Perú

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Dedios Mimbela Ninell Janett

2016-07-01

Full Text Available Se denomina radiación solar a los conjuntos de radiaciones electromagnéticas emitidas por el sol. Esta energía juega un papel determinante en diversos procesos en la biosfera, siendo uno de los factores importantes en los cambios de clima terrestre. Teniendo en cuenta sus beneficios, también existen los daños que puede causar en animales, plantas y humanos al tener una exposición prolongada. En las últimas dos décadas, se comprobó una disminución gradual de la capa de ozono estimada de 0.4 s 0.5 % por año. En búsqueda de una respuesta sobre el nivel de daño y su dinamismo estacional sobre una región del norte del Perú es por el cual se realiza el análisis del comportamiento del índice de radiación ultravioleta (UV-B. Los resultados, representan una herramienta y una alerta a fin de informar a la población sobre las formas de cómo evitar los problemas e impactos en la piel.

CONCRETO TRANSLÚCIDO – LUZ NATURAL PARA AMBIENTES FECHADOS

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Sayonara Michelle Mesquita Paiva Paiva

2017-08-01

Full Text Available RESUMO: O concreto por ter ampla utilização na construção civil, é constantemente objeto de pesquisas entre os estudiosos, sempre com o intuito de melhorar suas propriedades e aumentar seu uso nas edificações. O concreto é uma mistura de aglomerantes, agregados, aditivos e água. O concreto trouxe para a construção civil a possibilidade de projetar e executar as mais variadas formas, no entanto sempre foi um desafio para arquitetos e engenheiros a questão da iluminação nos ambientes fechados. Foi diante dessa dificuldade que surgiu um novo material no mercado, um concreto capaz de aliar as propriedades do concreto convencional com a iluminação natural, o Concreto Translúcido. O Concreto Translúcido é composto por concreto convencional e fibras ópticas, são essas fibras que permitem a passagem de luz através do concreto, conferindo assim um material favorável ao meio ambiente, tendo em vista que o consumo de energia pode ser reduzido. Este trabalho tem por objetivo mostrar as características desse novo material, suas vantagens e desvantagens e suas aplicações no Brasil e no mundo.

Legitimidade e não legitimidade das experiências dos sofrimentos e adoecimentos de longa duração

OpenAIRE

Canesqui, Ana Maria

2018-01-01

Resumo Discute-se a legitimidade e não legitimidade das experiências de adoecimentos e sofrimentos de longa duração selecionados, considerados ou não doenças pelos diagnósticos médicos, como a dor, a fadiga crônica e a “pressão alta”, usando pesquisas internacionais e nacionais sociológicas e antropológicas em saúde. As análises dos relatos de adoecidos ou de profissionais de saúde nas pesquisas consideradas exploram o assunto, suas implicações, reflexos e ambiguidades geradas nos sujeitos e ...

Simulação computacional integrada para a consideração da luz natural na avaliação do desempenho energético de edificações

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Evelise Leite Didoné

Full Text Available A luz natural é uma importante estratégia para redução do consumo de energia em edificações. Para sua previsão, recomenda-se a utilização de programas de simulação que empregam arquivos climáticos e processam as simulações com o conceito do Daylight Coefficients. O EnergyPlus, programa para simulação termoenergética, é uma dessas ferramentas. Porém, este software possui limitações no módulo de iluminação natural que superestimam a luz natural em ambientes internos. Para contornar essas limitações, o presente trabalho propõe uma metodologia para avaliação da eficiência energética, considerando o aproveitamento da luz natural, através da utilização de dois programas. A metodologia consiste na avaliação do desempenho luminoso e energético através de simulação com os programas Daysim e EnergyPlus. O Daysim produz um relatório que descreve o controle da iluminação artificial que é utilizado na simulação energética do EnergyPlus, que calcula o consumo energético final dos ambientes analisados. Os resultados indicam que a metodologia proposta mostrou-se adequada para suprir as limitações do EnergyPlus e para a avaliação da eficiência energética em edificações, considerando o aproveitamento da luz natural. Este trabalho mostra um caminho alternativo e confiável para a consideração do aproveitamento da iluminação natural na avaliação da eficiência energética de edificações.

Potencial evocado auditivo de longa latência: diferenças na forma de contagem do estímulo raro

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Rubia Soares Bruno

2016-02-01

Full Text Available RESUMO Objetivo: identificar se existe diferença nos achados do Potencial Evocado Auditivo de Longa Latência em relação à latência e amplitude, em diferentes modos de contagem do estimulo raro, sendo contando mentalmente ou marcando no papel (sem memorizar. Métodos: esse estudo teve caráter prospectivo e transversal. A amostra foi composta por conveniência sendo constituída por 49 indivíduos, sendo 29 do gênero feminino e 20 do gênero masculino. Foram realizados os seguintes procedimentos: Inspeção Visual do Meato Acústico Externo, Audiometria Tonal Liminar, Medidas de Imitância Acústica e Potencial Evocado Auditivo de Longa Latência, o qual foi realizado duas vezes, uma após a outra, com os indivíduos atentando ao estímulo raro, começando sempre contando mentalmente e após marcando em um papel. Resultados: houve diferença estatisticamente significante entre as orelhas para as latências de P1, P2 e amplitude de N1 para o método de marcação no papel, da latência de N1 para o método de contagem mental dos estímulos raros, e da amplitude de P2 em ambos os métodos, porém com todos os valores dentro da faixa de normalidade. Além disso, a diferença estatisticamente significante também foi evidente na comparação entre os gêneros, sendo encontrados valores de latência maiores de P2 e N2 para o gênero masculino em ambos os métodos de contagem dos estímulos raros. A amplitude de P1, P2 e P3 foi menor no gênero masculino nas diferentes formas de contagem, sendo no P2 a diferença apenas no método contando mentalmente. Ao compararmos os métodos, houve diferença estatisticamente significante apenas para a latência de P2, a qual foi maior para o método marcando no papel. Conclusão: não houve diferença para as latências e amplitudes dos potenciais evocados auditivos de longa latência na comparação da contagem do estímulo raro (contando mentalmente e marcando no papel para quase todos os potenciais, com

Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).

Science.gov (United States)

Funk, Janet L; Frye, Jennifer B; Oyarzo, Janice N; Zhang, Huaping; Timmermann, Barbara N

2010-01-27

Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was nontoxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO.

Avaliação de sistemas de janela para suporte a decisões de projeto quanto ao equilíbrio de ganhos de luz e calor

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Kamila Mendonça de Lima

Full Text Available O projeto de janelas considera os efeitos do meio externo, tais como o ganho de calor solar e a iluminação natural, os quais podem ser conflitantes. Este trabalho avalia o desempenho de diferentes alternativas de sistemas de janela para suporte a decisões de projeto quanto ao equilíbrio de ganhos de luz e calor no ambiente interno, com ênfase no uso de escritório no contexto do clima quente e úmido. Para isso, simulações computacionais integradas utilizando os programas Daysim e EnergyPlus foram realizadas, considerando-se o acionamento das lâmpadas apenas quando a luz natural não é suficiente para atender ao uso do ambiente. Foram variados o percentual de área de abertura, o tipo de vidro e o ângulo de sombreamento, simultaneamente, identificando-se soluções de compromisso quanto aos critérios de disponibilidade e uniformidade da luz e demanda de energia elétrica no ambiente. O controle solar pelo uso de dispositivo de proteção solar apresentou resultados substancialmente melhores que o controle solar apenas pela redução da transmissão da radiação solar do vidro. A avaliação realizada contribui para o aprofundamento da compreensão do impacto de diferentes variáveis de projeto nos fenômenos que caracterizam o desempenho da abertura de uma edificação.

Optimización de un juego de reactivo para determinar fósforo por método ultravioleta Determination of phosphorus presence by UV method and the of a reactant kit optimization

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Lisandra García Borges

2009-08-01

Full Text Available Cada día, en la medicina clínica, cobra mayor auge el estudio de las enfermedades relacionadas con la formación del esqueleto y el metabolismo de los minerales, de gran importancia en afecciones renales y las relacionadas con la nutrición, donde desempeña una función primordial el ion fósforo. Con vistas a ofertar a los laboratorios clínicos de Cuba un diagnosticador para determinar fósforo por un método ultravioleta, se formuló un monorreactivo listo para su uso, realizando la optimización de este, así como de la técnica de análisis diseñada para su determinación, la cual es aplicable en los laboratorios clínicos de la red de salud que cuentan con el equipamiento tecnológico para la lectura en el espectro ultravioleta. Se optimizó cada uno de los componentes del monorreactivo, así como la técnica analítica mediante diseños experimentales, y quedaron establecidos los valores óptimos de cada uno. Adicionalmente, se realizó una evaluación con el reactivo optimizado donde se obtuvo una curva lineal en el intervalo de interés clínico y un coeficiente de variación menor del 3 %.Every day, in clinical medicine, increase the interest for the diseases study related to skeletal development and the mineral metabolism, very important in renal affections and those related to nutrition, where it has an essential role the phosphorus ion. To offer Cuban clinical laboratories with diagnosis tool to determine the presence of phosphorus by a UV method, we formulated a monoreactive component ready for use, performing its optimization, as well as of the analysis technique designed to its assessment, which is applicable in clinical laboratories of health network with the technological equipment to read in UV spectrum. Each monoreactive component was optimized, as well as the analytical technique by means of experimental designs, staying the optimal values of each. Also, we performed an assessment using optimized reactive obtaining a

In Silico and In Vitro Anticancer Activity of Isolated Novel Marker Compound from Chemically Modified Bioactive Fraction from Curcuma longa (NCCL).

Science.gov (United States)

Naqvi, Arshi; Malasoni, Richa; Gupta, Swati; Srivastava, Akansha; Pandey, Rishi R; Dwivedi, Anil Kumar

2017-10-01

Turmeric ( Curcuma longa ) is reported to possess wide array of biological activities. Herbal Medicament (HM) is a standardized hexane-soluble fraction of C. longa and is well known for its neuroprotective effect. In this study, we attempted to synthesize a novel chemically modified bioactive fraction from HM (NCCL) along with isolation and characterization of a novel marker compound (I). NCCL was prepared from HM. The chemical structure of the marker compound isolated from NCCL was determined from 1D/2D nuclear magnetic resonance, mass spectroscopy, and Fourier transform infrared. The compound so isolated was subjected to in silico and in vitro screenings to test its inhibitory effect on estrogen receptors. Molecular docking studies revealed that the binding poses of the compound I was energetically favorable. Among NCCL and compound I taken for in vitro studies, NCCL had exhibited good anti-cancer activity over compound I against MCF-7, MDA-MB-231, DU-145, and PC-3 cells. This is the first study about the synthesis of a chemically modified bioactive fraction which used a standardized extract since the preparation of the HM. It may be concluded that NCCL fraction having residual components induce more cell death than compound I alone. Thus, NCCL may be used as a potent therapeutic drug. In the present paper, a standardized hexane soluble fraction of Curcuma longa (HM) was chemically modified to give a novel bioactive fraction (NCCL). A novel marker compound was isolated from NCCL and was characerized using various spectral techniques. The compound so isolated was investigated for in-silico screenings. NCCL and isolated compound was subjected to in-vitro anti-cancer screenings against MCF 7, MDA MB 231 (breast adenocarcinoma) and DU 145 and PC 3 cell lines (androgen independent human prostate cancer cells). The virtual screenings reveals that isolated compound has shown favourable drug like properties. NCCL fraction having residual components induces more cell

Prospective of curcumin, a pleiotropic signalling molecule from Curcuma longa in the treatment of Glioblastoma.

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Luthra, Pratibha Mehta; Lal, Neetika

2016-02-15

GBM (Glioblastoma) is the most malignant human brain tumor with median survival of one year. The treatment involves surgery, radiotherapy and adjuvant chemotherapy mostly with the alkylation agents such as temozolomide (TMZ). Dietary polyphenol curcumin, isolated from the rhizome of the Curcuma longa (turmeric), has emerged as remarkable anti-cancer agent in the treatment of various peripheral cancers such as blood, lymphomas, multiple myeloma, melanoma as well as skin, lung, prostate, breast, ovarian, bladder, liver, gastrointestinal tract, pancreatic and colorectal epithelial cancers with a pleiotropic mode of action and also showed promise in alleviation of GBM. In this review, the mechanism of anticancer effect of curcumin in GBM has been discussed extensively. The clinical safety and pharmacokinetics of curcumin has been scrutinized to combat the challenges for the treatment of GBM. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Herbal composition of Cinnamomum cassia, Pinus densiflora, Curcuma longa and Glycyrrhiza glabra prevents atherosclerosis by upregulating p27 (Kip1) expression.

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Lee, Jung-Jin; Lee, Ji-Hye; Cho, Won-Kyung; Han, Joo-Hui; Ma, Jin Yeul

2016-07-28

Kiom-18 is a novel composition of Cinnamomum cassia, Pinus densiflora, Curcuma longa and Glycyrrhiza glabra. Curcuma longa and Glycyrrhiza glabra, which are traditional medicines in Asia, have been reported to demonstrate preventive effects against atherosclerosis; however, they have not yet been developed into functional atherosclerosis treatments. We therefore studied the anti-atherosclerotic effects and possible molecular mechanisms of Kiom-18 using vascular smooth muscle cells (VSMCs). To assess the anti-proliferative effect of Kiom-18 in vitro, we performed thymidine incorporation, cell cycle progression, immunoblotting and immunofluorescence assays in VSMCs stimulated by platelet derived-growth factor (PDGF)-BB. In addition, we used LDLr knockout mice to identify the effects of Kiom-18 as a preliminary result in an atherosclerosis animal model. Kiom-18 inhibited platelet-derived growth factor (PDGF)-BB-stimulated-VSMC proliferation and DNA synthesis. Additionally, Kiom-18 arrested the cell cycle transition of G0/G1 stimulated by PDGF-BB and its cell cycle-related proteins. Correspondingly, the level of p27(kip1) expression was upregulated in the presence of the Kiom-18 extract. Moreover, in an atherosclerosis animal model of LDLr knockout mice, Kiom-18 extract showed a preventive effect for the formation of atherosclerotic plaque and suppressed body weight, fat weight, food treatment efficiency, neutrophil count, and triglyceride level. These results indicate that Kiom-18 exerts anti-atherosclerotic effects by inhibiting VSMC proliferation via G0/G1 arrest, which upregulates p27(Kip1) expression.

Anticoccidial activity of Curcuma longa L. in broilers

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Rao Zahid Abbas

2010-02-01

Full Text Available Comparative efficacy of turmeric (Curcuma longa L. crude powder and salinomycin sodium on the occurrence of coccidiosis and growth performance of broiler was evaluated. A total of 90, day-old chicks were randomly divided into six groups. From first day onward, ration was supplemented with 1, 2 and 3 % turmeric powder in groups 2, 3 and 4, respectively, group 1 received salinomycin sodium @ 12 g 50 kg-1 feed while groups 5 and 6 were kept as infected un-medicated and uninfected un-medicated controls. First five groups were infected with Eimeria tenella sporulated oocysts @ 1,00,000/chick at the age of 20 days. Body weight gain, feed consumption, feed conversion ratio were investigated throughout the experimental period, and bloody diarrhea and oocysts excretions were investigated at the first and the second week after infection. Maximum coccidiostatic effect was observed with turmeric (3% showing mild bloody diarrhea as compared to other infected groups receiving turmeric containing rations. This effect was comparable with a standard coccidiostat i.e., salinomycin sodium. Similarly, the weight gain in the groups treated with salinomycin sodium (2280g and 3% turmeric (2293g were also significantly higher (p < 0.05 than that of infected control group (1955g. In the groups treated with ration supplemented with 3% turmeric powder and salinomycin sodium, the peak excretion of oocysts was delayed about 1 or 2 days relative to the control infected group. Concentration-dependent coccidiostatic effect of turmeric suggested that further studies should be carried out to determine the possible maximum safe levels of turmeric with least toxic effects to be used as coccidiostat.

Methodology of technical analysis to reduce cost in the planning of the works of 'Energy for All' program in Sao Paulo, Brazil; Metodologia de analise tecnica para reducao de custo no planejamento das obras do programa 'Luz para Todos' em Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Betiol Junior, Genesio; Strazzi, Paulo Ernesto; Carmo, Jose R. do; Ribeiro, Fernando Selles [Comissao de Eletrificacao Rural do Estado de Sao Paulo (CERESP), SP (Brazil)

2006-07-01

This article relates the development of a research about low cost for rural electrification projects, which have been used like a base to develop a technical analysis in whole projects of the program 'Luz para Todos'. This program was made in 2002 with the purpose to offer electricity for whole people in Brazilian rural area. This method was developed seeking in to achieve cost reduction in the planning made by electric companies in Sao Paulo state. At first, were analyzed the rural electric projects made by electricity companies in the program 'Luz da Terra', in front of to the commitment in achieving cost reduction in the rural electric projects. The program 'Luz da Terra' was made whit a social purpose and it was developed in the whole Sao Paulo state, during 1996 until 2004. One of the main demands to achieve reasonable costs and to allow the program's viability was the previous analyses of rural distribution projects, before them changing to work of electricity, checking out if they had well defined. social, technical and economics methods. For that, were chosen quantitative and non-quantitative indicators, agreement whit a comparative analysis of each company performance in the program 'Luz da Terra', in agreement whit historical series, based on the group of the final result of each distribution electricity project. In a second moment, the same methodology was adjusted to confront the plans data of each company's future works in the program 'Luz para Todos', using the results of the first program. The research allowed the identification of some planner's tendencies when developing from a more rigorous model of low cost, like was the program 'Luz da Terra', to the actual program 'Luz para Todos'. Applied to all companies in the Sao Paulo state, the study served as a support to renegotiate budgets, what provided savings of more than US$ 10,000.000 in a total of 42

An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro.

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Mohankumar, Sureshkumar; McFarlane, James R

2011-03-01

Curcuma longa (turmeric) has been used widely as a spice, particularly in Asian countries. It is also used in the Ayurvedic system of medicine as an antiinflammatory and antimicrobial agent and for numerous other curative properties. The aim of this study was to investigate the effects of an aqueous extract of Curcuma longa (AEC) on tissues involved in glucose homeostasis. The extract was prepared by soaking 100 g of ground turmeric in 1 L of water, which was filtered and stored at -20°C prior to use. Pancreas and muscle tissues of adult mice were cultured in DMEM with 5 or 12 mmol/L glucose and varying doses of extract. The AEC stimulated insulin secretion from mouse pancreatic tissues under both basal and hyperglycaemic conditions, although the maximum effect was only 68% of that of tolbutamide. The AEC induced stepwise stimulation of glucose uptake from abdominal muscle tissues in the presence and absence of insulin, and the combination of AEC and insulin significantly potentiated the glucose uptake into abdominal muscle tissue. However, this effect was attenuated by wortmannin, suggesting that AEC possibly acts via the insulin-mediated glucose uptake pathway. In summary, water soluble compounds of turmeric exhibit insulin releasing and mimicking actions within in vitro tissue culture conditions. Copyright © 2010 John Wiley & Sons, Ltd.

Educação permanente: instrumento de trabalho do enfermeiro na instituição de longa permanência

OpenAIRE

Silva, Bárbara Tarouco da; Barlem, Edison Luiz Devos; Lunardi, Valeria Lerch; Santos, Silvana Sidney Costa

2008-01-01

A questão educacional na enfermagem é ampla, podendo referir-se à educação formal em cursos técnicos, de graduação e de pós-graduação, ou à educação em saúde voltada aos treinamentos em serviço. Ante a problemática do envelhecimento populacional, as características da sociedade moderna e o uso crescente de Instituições de Longa Permanência (ILPs) como residência dos idosos, a proposta deste texto reflexivo é enfatizar a relevância e necessidade da educação permanente para os trabalhadores que...

Tipo de luz na multiplicação in vitro de framboeseira (Rubus idaeus L. 'Batum' Light type in the in vitro multiplication of raspberry plants (Rubus idaeus L. 'Batum'

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Alan Cristiano Erig

2005-12-01

Full Text Available O objetivo deste trabalho foi determinar um possível tipo de luz mais ativo que a luz branca, de forma a aumentar a eficiência da multiplicação in vitro de framboeseira 'Batum', em relação ao número de brotos, de folhas e a taxa de multiplicação. Para isso, os tratamentos consistiram em cinco diferentes tipos de luz sob os quais os explantes cresceram (branca - testemunha, vermelha, amarela, azul e verde, fornecidas por meio da modificação do espectro luminoso das lâmpadas fluorescentes brancas-frias, utilizando filtros coloridos de acetato celulose, do tipo Lee Filters (Walworth Ind. Estate, Andover, England. O meio de cultura constituiu-se dos sais e vitaminas de MS, adicionado de mioinositol (100mgL-1, sacarose (30gL-1, ágar (6gL-1 e de BAP (4,44µM. A eficiência da multiplicação in vitro de framboeseira 'Batum', em relação às variáveis analisadas, aumentou com a utilização da luz verde. A luz vermelha também incrementou o número médio de brotos; no entanto, sua morfologia foi modificada, com uma menor expansão das folhas, os brotos finos e os entrenós alongados.The aim of this work was to determine a possible light type more active than the white light, in way to increase the efficiency of the in vitro multiplication of raspberry 'Batum', in relation to the shoots and leaves number, and the multiplication rate. For that, the treatments consisted of five different light types (white - control, red, yellow, blue and green, under which the explants grew, supplied through the modification of the luminous spectrum of the white-cold fluorescent lamps, using colored filters of acetate cellulose, Lee Filters type (Walworth Ind. Estate, Andover, England. The culture medium was constituted of MS salts and vitamins, added of myo-inositol (100mgL-1, sucrose (30gL-1, agar (6gL-1 and BAP (4.44µM. The efficiency of the in vitro multiplication of raspberry 'Batum', in relation to the analyzed variables, increased with the use of

Difracción de luz a través de una pluma de ave

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Hugo Pérez García

2012-01-01

Full Text Available Se ha utilizado una pluma de ave para estudiar la difracción de la luz, tanto de forma cualitativa como cuantitativa. La medida experimental de la separación entre los puntos luminosos del patrón de difracción obtenido con un puntero láser ha permitido determinar el espaciado entre las barbas y entre las bárbulas de la pluma. Los resultados obtenidos muestran un acuerdo satisfactorio con los correspondientes a la estructura típica de una pluma. Los materiales empleados, los conceptos involucrados y los resultados experimentales convierten a esta experiencia en un excelente recurso didáctico para el estudio de la difracción, tanto en los primeros cursos universitarios como en los últimos cursos del Bachillerato.

Tomate longa vida desidratado em diferentes temperaturas de secagem = Drying of tomato at different temperatures

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Aurélio Vinicius Borsato

2007-01-01

Full Text Available A demanda no consumo de tomate desidratado cresceu nos últimos anos,principalmente pela justificativa de que o tomate contém substâncias bioativas. A pesquisa realizada objetivou avaliar três condições de secagem (80oC; 100oC; 100oC por 3h seguida de 80oC, aplicadas ao tomate longa vida cv. Carmem para obtenção de produto desidratadocom umidade residual projetada para 60% do seu peso. Foi usado um secador de pouca capacidade, contendo circulação forçada de ar e cinco bandejas. Os tomates frescos, fatiados e inteiros, renderam em peso de produto desidratado 12,2-13,6% e 7,5-8,5%, respectivamente. O tratamento que aplicou a temperatura de 100ºC por 3h seguida de 80ºCpor 4h e 24min, com a porta fechada do secador, resultou em produto desidratado de boa aparência e sem nenhuma fatia queimada, por isso foi o recomendado para a secagem de fatias de tomate longa vida a cv. Carmem.The demand for the consumption of dried tomatoes has grown in recent years, especially under the justification that tomatoes contain allegedly healthy bioactive substances. The research aimed to evaluatethree drying conditions (80oC; 100oC; 100oC for 3h followed by 80oC applied to cv. Carmem long-life tomatoes in order to obtain a dehydrated product with a projected residual humidity of 60% in weight. A small-capacity dryer was used, equipped with forcedaircirculation and five trays. The fresh tomatoes, both sliced and whole, yielded 12.2-13.6% and 7.5-8.5% in weight of dehydrated product, respectively. The treatment consisting in the application of a temperature of 100ºC for 3h followed by 80ºC for 4h and 24min, with the door of the dryer closed, resulted in a dehydrated product with good appearance and without any burned slices; therefore, it was recommended for drying cv. Carmem long-life tomato slices.

Acid hydrolysis of Curcuma longa residue for ethanol and lactic acid fermentation.

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Nguyen, Cuong Mai; Nguyen, Thanh Ngoc; Choi, Gyung Ja; Choi, Yong Ho; Jang, Kyoung Soo; Park, Youn-Je; Kim, Jin-Cheol

2014-01-01

This research examines the acid hydrolysis of Curcuma longa waste, to obtain the hydrolysate containing lactic acid and ethanol fermentative sugars. A central composite design for describing regression equations of variables was used. The selected optimum condition was 4.91% sulphuric acid, 122.68°C and 50 min using the desirability function under the following conditions: the maximum reducing sugar (RS) yield is within the limited range of the 5-hydroxymethylfurfural (HMF) and furfural concentrations. Under the condition, the obtained solution contained 144 g RS/L, 0.79 g furfural/L and 2.59 g HMF/L and was directly fermented without a detoxification step. The maximum product concentration, average productivity, RS conversion and product yield were 115.36 g/L, 2.88 g/L/h, 89.43% and 64% for L-lactic acid; 113.92 g/L, 2.59 g/L/h, 88.31% and 63.29% for D-lactic acid; and 55.03 g/L, 1.38 g/L/h, 42.66 and 30.57%, respectively, for ethanol using a 7-L jar fermenter. Copyright © 2013. Published by Elsevier Ltd.

Processamento radiográfico - câmara escura portátil: relação entre filtro de luz e densidade de base + véu

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TAMBURÚS José Roberto

1999-01-01

Full Text Available O objetivo desta pesquisa foi avaliar o efeito sobre a densidade de base + véu de filmes radiográficos, decorrente do uso da luz filtrada pelo polímero acrílico utilizado nas câmaras portáteis para processamento radiográfico. Filmes Kodak Ultra-speed e Ektaspeed Plus foram colocados no interior de uma câmara desse tipo e submetidos durante cinco minutos às condições de iluminação natural e artificial em que elas são rotineiramente utilizadas. Depois disso, os filmes foram processados pelo método temperatura-tempo em câmara escura convencional, juntamente com filmes dos mesmos grupos de sensibilidade que serviram como controle. Os valores densitométricos obtidos das amostras dos filmes foram analisados pelo teste de Mann-Whitney que indicou ao nível de 1% de significância, que os filmes submetidos às condições da câmara portátil apresentaram densidades de base + véu maiores em relação aos grupos controle. Os resultados mostraram que o filme Ektaspeed Plus apresentou valores maiores de densidade de base + véu em comparação com o filme Ultra-speed e que, embora o acrílico filtre a luz de forma similar ao filtro Kodak GBX 2, a maior intensidade de luz no interior da câmara escura portátil ocasionou o aumento na densidade de base + véu.

Fórum das instituições filantrópicas de longa permanência para idosos: parceria em rede de apoio no cuidado institucional ao idoso

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Rosamaria Rodrigues Garcia

Full Text Available Resumo O artigo descreve o histórico, a metodologia e a evolução do Fórum das Instituições Filantrópicas de Longa Permanência para Idosos (ILPI da Região Metropolitana de São Paulo, e contextualiza sua trajetória diante dos avanços normativos que regulamentam essas instituições atualmente. Foi realizado um estudo retrospectivo, descritivo, de abordagem qualitativa, por meio da leitura e análise das atas das reuniões no período entre 1999 e 2015. Observou-se que a articulação em rede, proporcionada pelas reuniões ao longo dos 16 anos de atividade, pode auxiliar a organização, o planejamento e a manutenção das ILPI, contribuindo para melhorar a qualidade da prestação dos serviços conforme a legislação vigente, promovendo aproximação e engajamento de parceiros na busca pela profissionalização dos cuidados institucionais de longa duração e pela excelência na assistência ao idoso, e no aprimoramento e capacitação dos profissionais, processos e protocolos institucionais.

Termitarium-inhabiting Bacillus endophyticus TSH42 and Bacillus cereus TSH77 colonizing Curcuma longa L.: isolation, characterization, and evaluation of their biocontrol and plant-growth-promoting activities.

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Chauhan, Ankit Kumar; Maheshwari, Dinesh Kumar; Kim, Kangmin; Bajpai, Vivek K

2016-10-01

Bacillus strains were isolated from termitarium soil and screened for their antifungal activity through the production of diffusible and volatile metabolites. Further, the bacterial strains that showed antifungal activity were evaluated for their biocontrol potential on the basis of their plant-growth-promoting attributes. Termitarium-inhabiting Bacillus strains TSH42 and TSH77 significantly reduced the growth of pathogenic fungus Fusarium solani, controlled the symptoms of rhizome rot in turmeric (Curcuma longa L.), and demonstrated various plant-growth-promoting traits in different in vitro assays. On the basis of morphological, physiological, biochemical, and 16S rDNA characteristics, isolates TSH42 and TSH77 were identified as Bacillus endophyticus (KT379993) and Bacillus cereus (KT379994), respectively. Through liquid chromatography - mass spectrometry analysis, acidified cell-free culture filtrate (CFCF) of B. cereus TSH77 was shown to contain surfactin and fengycin, while CFCF of B. endophyticus TSH42 contained iturin in addition to surfactin and fengycin. Treatment of the turmeric (C. longa L.) plants with TSH42 and TSH77 significantly reduced the percentage incidence of rhizome rot disease caused by F. solani. The same treatment also increased the fresh rhizome biomass and plant growth in greenhouse conditions.

As representações sociais de funcionários de uma Instituição de Longa Permanência sobre violência no interior de Minas Gerais

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Alcione Tavora Kullok

Full Text Available O Brasil está passando por um processo de envelhecimento populacional rápido e intenso, estimando-se que 1% dos idosos brasileiros esteja institucionalizado. Apesar dos avanços investigativos na área da geriatria e gerontologia da última década, os estudos acerca das Instituições de longa permanência no país ainda são incipientes, deparando-se com sérios problemas relacionados à qualidade do cuidado. Neste artigo, de abordagem qualitativa e cunho exploratório-descritivo, foram investigadas as representações sociais de funcionários sobre violência em uma instituição de longa permanência de um município de Minas Gerais. Os dados, oriundos da transcrição das entrevistas, foram processados por meio de análise de conteúdo. Os entrevistados referiram-se à violência e relataram suas experiências sinceras e profundas como vitimas, porém, quanto aos idosos, era como se a violência sempre acontecesse extramuro, nunca dentro da Instituição, percebendo-se, às vezes, uma denúncia velada, mas não revelada.

ESTUDIO CINÉTICO DE LA FOTODEGRADACIÓN DEL NARANJA DE METILO EN PRESENCIA DE TiO2: EFECTO DE LA FUENTE DE RADIACIÓN U.V., CONCENTRACIÓN DEL AZO-COLORANTE Y DEL CATALIZADOR

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Juan M. Hernández

2012-01-01

Full Text Available En este trabajo se estudió la degradación fotocatalítica de soluciones acuosas de naranja de metilo con óxido de titanio (Degussa P-25 iluminado con luz ultravioleta artificial y/o solar. Se realizaron experimentos para investigar el efecto de variables de operación tales como fuente de radiación U.V., concentración del azo- colorante y concentración del catalizador. Los resultados mostraron que la velocidad de degradación se vio afectada por parámetros experimentales tales como la concentración del colorante y/o la concentración del catalizador. La cinética de degradación cambia cuando se difiere en la fuente de radiación U.V., siendo de orden 0.5 en el caso de la radiación U.V. proporcionada por una lámpara de 150 W y de orden cero cuando se utilizó radiación U.V. solar. La degradación del azo-compuesto alcanzó el 100% en todos los casos.

Un gene con intrones en vez de exones / Envejecimiento Prematuro de la Piel

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Tobías Mojica

1996-04-01

Full Text Available Un gene con intrones en vez de exones. La noción de que los genes son discontinuos (compuestos de exones e intrones en forma alterna y en cuya organización los exones representan regiones presentes, por medio del código genético en las proteínas, y los intrones nadie sabe todavía que representan produjo una cierta cantidad de desasosiego entre los genetistas mayores de edad, pero hoy día es ampliamente aceptada, con poco o ningún dolor, y se ha convertido en parte del cánon científico. / Envejecimiento Prematuro de la Piel. La exposición a largo plazo de la piel a la luz ultravioleta proveniente del sol resulta en daño al colágeno de la piel y a la elastina de la matriz extracelular; se cree que este daño es responsable de la apariencia típicamente arrugadita de la piel expuesta al sol por mucho tiempo (como en los vaqueros de los comerciales de la televisión.

Gas chromatography coupled with mass spectrometric characterization of Curcuma longa: Protection against pathogenic microbes and lipid peroxidation in rat's tissue homogenate.

Science.gov (United States)

Hassan, Waseem; Gul, Shehnaz; Rehman, Shakilla; Kanwal, Farina; Afridi, Muhammad Siddique; Fazal, Hina; Shah, Ziarat; Rahman, Ataur; da Rocha, Joao B T

2016-03-01

The present study was designed to investigate the mineral content and antimicrobial activity of Curcuma Longa extracts and its essential oil. We also determined the lipid peroxidation inhibition activity of the ethanolic extract against sodium nitroprusside (SNP) induced thiobarbituric acid reactive species (TBARS) formation in rat's brain, kidney and liver homogenates. Major constituents of essential oil identified by gas chromatography and mass spectrometry (GCMS) were beta-sesquiphellandrene (38.69%), alpha-curcumene (18.44%) and p-mentha-1,4 (8)-diene (16.29%). Atomic absorption spectroscopy (AAS) was used for the quantitative estimation of Calcium (Ca), Magnesium (Mg), Iron (Fe), Copper (Cu), Zinc (Zn), Chromium (Cr), Nickel (Ni) and Manganese (Mn). The extract showed highest Mg (49.4 mg/l) concentration followed by Ca (35.42 mg/l) and Fe (1.27 mg/l). Our data revealed that the ethanolic extract of Curcuma Longa at 1-10 mg/kg significantly inhibited TBARS production in all tested homogenates. Crude extracts and essential oil were tested against three gram positive bacteria i.e. Bacillus subtilis, Bacillus atrophoeus, Staphylococcus aureus, six gram negative bacteria i.e. Escherichia coli, Klebsiella pneumonias, Salmonella typhi, Pseudomonas aeruginosa, Erwinia carotovora, Agrobacterium tumefaciens and one fungal strain namely Candida albicans by disc diffusion assay. Essential oil showed highest anti-microbial activity as compared to the crude extracts. The present study confirms the significant antimicrobial and antioxidant potential of the studied plant, which can be considered as a diet supplement for a variety of oxidative stress induced or infectious diseases.

Estrés oxidativo, alimentación y suplementación antioxidante en patología ocular: historia breve y visión futura Oxidative stress, feeding and antioxidant supplementation in ocular pathology: brief history and future vision

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Alfredo Gutiérrez Maydata

2007-12-01

Full Text Available Los ojos están en riesgo particular de daño oxidativo debido a su alta exposición al oxígeno, gran cantidad de ácidos grasos oxidables en la retina y su también alta exposición a la luz, los contaminantes ambientales y los rayos ultravioleta. En el presente trabajo se discuten las evidencias encontradas del posible papel del daño oxidativo en la patogenia de diversos trastornos oculares (glaucoma, cataratas, retinopatía diabética, degeneración macular; y de la dieta y la suplementación con antioxidantes en su prevención y tratamiento. De momento las actuales recomendaciones se inclinan a la importancia de una dieta variada, alta en frutas y vegetales, no fumar, evitar el exceso de exposición al sol y a las radiaciones ultravioletas y en los pacientes diabéticos mantener un estricto control de la glicemia como la estrategia antioxidante más efectiva, mientras se investigan los beneficios probados de suplementos antioxidantes.The eyes are at risk of suffering oxidative damage due to their high exposure to oxygen, a great deal of fatty acids in the retina and also to light, environmental pollutants and ultraviolet rays. The present paper discussed the evidence found about the possible role of oxidative damage in the pathogenesis of several eye diseases (glaucoma, cataract, diabetic retinopathy, macular degeneration and the role of diet and antioxidant supplements in the prevention and treatment of such diseases. At present, the current recommendations cover the importance of a varied diet with high contents of fruits and vegetables, non-smoking, avoiding excessive exposure to the sun and ultraviolet radiations and a stict control of glycemic levels in diabetic patients as the most effective antioxidant strategy. The proven benefits of antioxidant supplements are being researched at present.

Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa.

Science.gov (United States)

Packiavathy, Issac Abraham Sybiya Vasantha; Priya, Selvam; Pandian, Shunmugiah Karutha; Ravi, Arumugam Veera

2014-04-01

Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such as Escherichia coli, Pseudomonas aeruginosa PAO1, Proteus mirabilis and Serratia marcescens, possibly by interfering with their QS systems. The antibiofilm potential of curcumin on uropathogens as well as its efficacy in disturbing the mature biofilms was examined under light microscope and confocal laser scanning microscope. The treatment with curcumin was also found to attenuate the QS-dependent factors, such as exopolysaccharide production, alginate production, swimming and swarming motility of uropathogens. Furthermore, it was documented that curcumin enhanced the susceptibility of a marker strain and uropathogens to conventional antibiotics. Copyright © 2012 Elsevier Ltd. All rights reserved.

Da escuridão para a luz: origem e extensão da Bíblia em braille no Brasil. Dissertação

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Marcos Adriano Lovera

2013-12-01

Full Text Available LOVERA, Marcos Adriano. Da escuridão para a luz: origem e extensão da Bíblia em braille no Brasil. Dissertação (Mestrado 2013. 176p. - Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte

Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus.

Science.gov (United States)

Chang, Hong-Bin; Chen, Bing-Huei

2015-01-01

The objectives of this study were to explore the inhibition mechanism of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus. In addition, human bronchus epithelial cell line BEAS-2B (normal cell) was selected for comparison. A high-performance liquid chromatography (HPLC) method was developed to separate and quantify the various curcuminoids in C. longa extract, including curcumin (1,714.5 μg/mL), demethoxycurcumin (1,147.4 μg/mL), and bisdemethoxycurcumin (190.2 μg/mL). A high-stability nanoemulsion composed of Tween 80, water, and curcuminoid extract was prepared, with mean particle size being 12.6 nm. The cell cycle was retarded at G2/M for both the curcuminoid extract and nanoemulsion treatments; however, the inhibition pathway may be different. H460 cells were more susceptible to apoptosis than A549 cells for both curcuminoid extract and nanoemulsion treatments. Growth of BEAS-2B remained unaffected for both the curcuminoid extract and nanoemulsion treatments, with a concentration range from 1 to 4 μg/mL. Also, the activities of caspase-3, caspase-8, and caspase-9 followed a dose-dependent increase for both A549 and H460 cells for both the treatments, accompanied by a dose-dependent increase in cytochrome C expression and a dose-dependent decrease in CDK1 expression. Interestingly, a dose-dependent increase in cyclin B expression was shown for A549 cells for both the treatments, while a reversed trend was found for H460 cells. Both mitochondria and death receptor pathways may be responsible for apoptosis of both A549 and H460 cells.

O Idoso residente em ILPI (Instituição de Longa Permanência do Idoso e o que isso representa para o sujeito idoso

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Maria Carla Nunes de Souza Costa

2013-12-01

Full Text Available Existem termos bem conhecidos para definir o tipo de residência para uma pessoa idosa, dentre eles, Asilo, Casa de Repouso, Abrigo, Instituição de Longa Permanência. Atualmente o termo mais utilizado é ILPI - Instituição de Longa Permanência do Idoso. Este último utilizado não como simples sinônimo de Asilo, mas é termo que implica uma nova organização e gestão de moradia para idosos. Este artigo tem como proposta discutir a velhice abrigada em moradia coletiva, fundamentalmente a do idoso residente em ILPI, e o que representa para esse sujeito o fato de residir nesse tipo de instituição. Para entender o morar do idoso em uma ILPI, buscamos primeiramente entender questões relacionadas à velhice em suas formas mais diversas, como por exemplo, o significado de ser velho em nossa sociedade, ligado a uma construção sociocultural, o corpo como revelador da velhice, e a memória como sustentadora da identidade. Para entender uma ILPI, pesquisamos um pouco sobre a história desse tipo de instituição, de como atualmente ela é interpretada pelas Ciências Sociais e pela Gerontologia, enfatizando seu cotidiano e buscando compreender novas formas de organizações para o morar do idoso.

Response of spores and young gametophytes of Cyathea delgadii Sternb. (Cyatheaceae and Blechnum brasiliense Desv. (Blechnaceae to different light levels Resposta de esporos e gametófitos jovens de Cyathea delgadii Sternb. (Cyatheaceae e Blechnum brasiliense Desv. (Blechnaceae aos diferentes níveis de luz

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Rosane Hiendlmeyer

2007-12-01

Full Text Available Light is a limiting factor for fern stablishment because it controls germination of light sensitive spores. The aim of this work was to study the effect of light levels on spore germination in two ornamental ferns native to the Atlantic forest, under natural conditions. Cyathea delgadii is a tree fern and Blechnum brasiliense, a subarborescent fern. The effect of light levels was analyzed in April and July/2003, in Florianópolis, Santa Catarina state, Brazil. Sterilized spores were sown in Erlenmeyer flasks containing mineral culture medium with macronutrients, iron, and benomyl 0.01%. The Erlenmeyer flasks were kept in 50 cm³ boxes covered with black shade netting, which gave 5, 22, 42, and 62% natural light. Irradiance and temperature were scored daily at 14:00 h during the study period. Higher percentages of germination were observed at 5 and 22% light for both species. Germination of Cyathea delgadii spores at 22% light reached 76% and mean germination time was 19.7 days; at 5% light, germination reached 83.5% and mean germination time was 20.16 days. Germination of Blechnum brasiliense at 22% light reached 76% and mean germination time was 9.06 days; at 5% light, germination reached 84% and mean germination time was 13.18 days. The highest light levels inhibited spore germination and the gametophytes died during the test period.Luz é um dos fatores limitantes para o estabelecimento das pteridófitas, pois controla a germinação de esporos fotossensíveis. O objetivo deste trabalho foi estudar o efeito de níveis de luz na germinação de esporos de duas pteridófitas ornamentais nativas da Floresta Atlântica, sob condições ambientais. Cyathea delgadii é uma samambaia arbórea e Blechnum brasiliense, subarborescente. O efeito dos níveis de luz foi analisado em abril e em junho/2003, em Florianópolis, SC, Brasil. Esporos esterilizados foram inoculados em "erlenmeyers" contendo meio de cultura composto pormacronutrientes, ferro e

LA TEORÍA DE LA ECOLOGÍA POBLACIONAL EXAMINADA A LA LUZ DE TEORÍAS ADAPTACIONISTAS

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Joaquín Garcilazo

2011-06-01

Full Text Available La idea de cambio radical en las organizaciones se ha discutido mayormente desde dos posturas teóricas. Una, impulsada por las teorías adaptacionistas, sostiene que el cambio es posible porque el ambiente no es algo inmodificable y los gerentes pueden ser agentes activos del mismo. La otra, soportada por la teoría de la ecología poblacional, sostiene que el cambio es imposible dada la inercia estructural a la que se enfrenta toda organización. En este trabajo se revisan cada una de estas aproximaciones y se discuten las implicancias de la teoría de la ecología poblacional a la luz de las teorías adaptacionistas.

Application of the business model Canvas in Microenterprises from Partners of the Savings and Credit Cooperative Luz del Valle

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Francisco Javier Monroy Espinosa

2017-12-01

Full Text Available The "Luz del Valle" Savings and Credit Cooperative is a financial institution with five thousand microentrepreneurial partners who have business units. These business units, generally informal, do not have a defined organizational structure or adequate management tools, which influences in the presence of economic problems such as arrears and non-payment of contracted obligations, mainly as a result of a low level of sales. Due to this situation, it is important for cooperatives to support their partners in finding solutions. This is part of the cooperative principles and values of mutual aid, social responsibility and education, training and information for its members, team leaders, managers and employees; these universal principles established by the International Cooperative Alliance (ICA are considered by the savings and credit cooperative "Luz del Valle" as strategies to accompany its partners in the development and growth of their business units. The cooperative organizes a Christmas Fair annually, where 60 microentrepreneurs participate. This event was the opportunity to develop, together with the Metropolitan University of Ecuador, a project that, in its first phase, trained in the formulation of strategies based on the application of the Business Model Canvas; the teaching of this tool, which allows creating, capturing and providing value for clients, was supported by the university community and the program of linkage with society that develops the aforementioned institution; the evaluation of the impact and the economic results are contemplated in a second phase.

Síntese do piperonal a partir do óleo essencial de pimenta longa (Piper hispidinervium C. DC. Synthesis of piperonal from essential oil of long-pepper (Piper hispidinervium C. DC.

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Marco Aurélio Cremasco

2012-06-01

Full Text Available O óleo essencial de pimenta longa (Piper hispidinervum C. DC é rico em safrol, tornando-o suscetível à reação de isomerização para a obtenção de cis, trans-isosafrol. O presente artigo apresenta a etapa de eletroxidação dos isômeros cis, trans-isosafrol advindos da isomerização direta do óleo essencial de pimenta longa, apresentando 99,7% de conversão em isosafrol glicol, o qual é sujeito à oxidação com conversão de 99% em piperonal, este apresentando 84,9% de pureza.The essential oil of long-pepper (Piper hispidinervum C. DC is rich in safrole, then susceptible to isomerization reaction to obtain cis, trans-isosafrole. In this paper it is presented the eletroxidation of cis, trans-isosafrole from direct isomerization of essential oil of long-pepper, with 99,7% of convertion to isosafrole glicol, that it is react by oxidation to convert 99% into piperonal with 84,9% purity.

Contribuições ao uso de diodos emissores de luz em iluminação pública

OpenAIRE

Rodrigues, Cláudio Roberto Barbosa Simões

2012-01-01

No intuito de aportar contribuições ao uso de diodos emissores de luz (ou LEDs, do inglês Light Emmiting Diodes) em sistemas de iluminação pública, cobrindo lacunas existentes no cenário nacional, este trabalho traz uma ampla análise sobre este tema. São apresentados conceitos básicos da fotometria clássica e um estudo sobre adaptações da fotometria para baixos níveis de luminância, que é a condição observada nas vias públicas durante o período noturno. Propõe-se a utilização d...

La junta luz di Juan Gelman: un oratorio contro il silenzio

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Arianna Fiore

2014-12-01

Full Text Available Juan Gelman is generally considered by critics to be one of the most important poets of modern Argentina. Born in Buenos Aires in 1930 from Russian-Jewish parents, he published his first collection of poems (Violín y otras cuestiones in 1956. He is a member of the generación del 60, made up of intellectuals influenced in their critical realism by the charisma of Raúl González Tuñón, forerunner of Argentina’s social and political poetry. This group was politically very active, as demonstrated by their experimental language and iconoclastic lyricism. Gelman’s later life was marked by his exile in the wake of the 1976 dictatorship, and by the desaparición of his son Marcelo Ariel, his daughter-in-law Claudia and his grand-daughter Andrea (born in prison. Since then, it was impossible for Juan Gelman to separate his personal plight from Argentina’s historical-political situation, and his poetry became more and more intimate and lyrical, marked by human drama. La junta luz, the author’s only theatre play, was written and published in this second phase.

O estudo da cultura organizacional por meio das práticas: uma proposta à luz do legado de Bourdieu

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Souza, Eda Castro Lucas de; Fenili, Renato Ribeiro

2016-01-01

Resumo O objetivo deste artigo é propor o estudo da cultura organizacional por meio das práticas de gestão, à luz do quadro teórico de Bourdieu. Para tanto, apresenta-se como objetivo secundário analisar o estado da arte dos estudos organizacionais que empregam esse quadro teórico. Inicialmente, é apresentada uma categorização das tendências predominantes no estudo da cultura e discorre-se sobre esse conceito, salientando sua abordagem como diretamente relacionada às práticas. O foco do estud...

Luz industrial e imagen tecnificada: de Moholy Nagy al C.A.V.S. (Center for Advanced Visual Studies)

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Quiroga Fernández, Sofía

2016-01-01

El desarrollo de la tecnología de la luz implicará la transformación de la vida social, cultural y económica. Tanto las consideraciones espaciales del Movimiento Moderno, como los efectos producidos por la segunda Guerra Mundial, tendrán efectos visibles en las nuevas configuraciones espaciales y en la relación simbiótica y recíproca que se dará entre ideología y tecnología. La transformación en la comprensión de la articulación espacial, asociada al desarrollo tecnológico, afectará al modo ...

[Extraction Optimization of Rhizome of Curcuma longa by Response Surface Methodology and Support Vector Regression].

Science.gov (United States)

Zhou, Pei-pei; Shan, Jin-feng; Jiang, Jian-lan

2015-12-01

To optimize the optimal microwave-assisted extraction method of curcuminoids from Curcuma longa. On the base of single factor experiment, the ethanol concentration, the ratio of liquid to solid and the microwave time were selected for further optimization. Support Vector Regression (SVR) and Central Composite Design-Response Surface Methodology (CCD) algorithm were utilized to design and establish models respectively, while Particle Swarm Optimization (PSO) was introduced to optimize the parameters of SVR models and to search optimal points of models. The evaluation indicator, the sum of curcumin, demethoxycurcumin and bisdemethoxycurcumin by HPLC, were used. The optimal parameters of microwave-assisted extraction were as follows: ethanol concentration of 69%, ratio of liquid to solid of 21 : 1, microwave time of 55 s. On those conditions, the sum of three curcuminoids was 28.97 mg/g (per gram of rhizomes powder). Both the CCD model and the SVR model were credible, for they have predicted the similar process condition and the deviation of yield were less than 1.2%.

Inflação inercial como um processo de longa memória: análise a partir de um modelo Arfima-Figarch

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Erik Alencar de Figueiredo

2009-06-01

Full Text Available O objetivo principal deste estudo é investigar a dependência de longo prazo da inflação brasileira, descrevendo-a como um processo fracionariamente integrado tanto na média quanto na variância. A metodologia empregada baseia-se na estimação de um modelo ARFIMA-FIGARCH, capaz de detectar a presença de memória longa em altas defasagens de um processo autorregressivo. Os principais resultados alcançados indicam que, para o período pós-Plano Real, a inflação brasileira exibe um comportamento estacionário em seus dois primeiros momentos com lento decaimento hiperbólico. Há indícios de longa memória na média e na variância do processo. Além disso, constatou-se, para esse período, uma recíproca influência entre a volatilidade e a taxa média de inflação.The aim of this paper is search for the long memory in the Brazilian inflation rate, describing it as a fractionally integrated process in the first and second moments. So, it is employed the more recent methodology of ARFIMA-FIGARCH models. The main result endorses the hypothesis of inertial inflation in the short and long run, and the Friedman's hypothesis of interaction between mean and volatility of price inflation.

GerminaÃÃo e crescimento de plÃntulas de Libidibia ferrea Mart. ex. Tul. em funÃÃo do peso de semente e condiÃÃes de temperatura e luz

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Fernanda Melo Gomes

2014-01-01

O objetivo deste trabalho foi estudar a germinaÃÃo de sementes e o estabelecimento de plÃntulas de Libidibia ferrea em funÃÃo do peso de semente, temperatura e luz. As sementes de L. ferrea foram separadas em trÃs classes de peso (leves, mÃdias e pesadas) e foram realizados em laboratÃrio os bioensaios de temperatura e luz, alÃm do experimento de sombreamento em casa de vegetaÃÃo. Para o experimento em laboratÃrio, o crescimento da parte aÃrea de plÃntulas apresentou melhor desempenho sob a a...

O bairro da Luz em São Paulo: questões antropológicas sobre o fenômeno da gentrification El barrio de la Luz en São Paulo: cuestiones antropológicas sobre el fenómeno de la gentrification The Luz district in São Paulo: anthropological questions on the phenomenon of gentrification

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Heitor Frúgoli Jr

2009-12-01

Full Text Available Esse artigo explora, numa perspectiva etnográfica, o alcance do conceito de gentrification com relação às mudanças (e também permanências sociais e urbanas em curso no bairro da Luz, localizado na área central da cidade de São Paulo, situado numa confluência entre processos de preservação patrimonial de instituições culturais, intervenções urbanísticas e um uso histórico por parte de vários grupos provenientes das classes populares. Tais questões serão tratadas com atenção aos seguintes tópicos: políticas locais de intervenção em áreas marcadas pela estigmatização, quando ocupadas predominantemente pelas classes populares; a revisão da oposição "práticas de intervenção" vs. "resistência dos grupos atingidos" (marcadas por certas divisões do ponto de vista analítico; por fim, a busca de definições mais precisas dos termos de comparação com outros casos emblemáticos (evitando perspectivas apriorísticas.Este artículo explora, en una perspectiva etnográfica, el alcance del concepto de gentrification con relación a los cambios (y también permanencias sociales y urbanos en curso en el barrio de la Luz , localizado en la área central de la ciudad de São Paulo, situado en una confluencia entre procesos de preservación patrimonial de instituciones culturales, intervenciones urbanísticas y un uso histórico por parte de varios grupos provenientes de las clases populares. Tales cuestiones serán tratadas con atención a los siguientes tópicos: políticas locales de intervención en áreas marcadas por la estigmatización, cuando ocupadas predominantemente por las clases populares; revisión de la oposición "prácticas de intervención" vs. "resistencia de los grupos afectados" (marcadas por ciertas divisiones del punto de vista analítico; y, por fin, la búsqueda de definiciones más precisas de los términos de comparación con otros casos emblemáticos (evitando perspectivas aprior

Antimicrobial effect of turmeric (Curcuma longa on chicken breast meat contamination

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TC Lourenço

2013-06-01

Full Text Available The aim of this study was to evaluate the efficacy of turmeric (Curcuma longa, also known in Brazil as saffron, on the reduction of Staphylococcus aureus and Escherichia coli counts in chicken meat. Forty breast meat samples were divided in two groups (A and B. In group A, 10³-10(4E. coli (ATCC 25922 cells were inoculated and group B samples were inoculated with 10(4-10(5S. aureus (ATCC 9801 cells, after which each group was divided in three samples. The first sample was analyzed immediately after inoculation. The second sample (control group was stored at 4 ºC for 48 hours and turmeric at 1% (w/w was added to the third sample, which was homogenized and then stored under the same conditions as the second sample. E. coli and S. aureus were enumerated in all samples. Mean bacterial counts determined for the control samples and for the samples with turmeric addition after 48h of storage were 1.83 x 10(4 CFU g-1 and 1.80 x 10(4 CFU g-1 for S. aureus, and 9.36 x 10³ CFU g-1 and 7.25 x 10³ CFU g-1 for E. coli, respectively. The results showed that there was no significant reduction in bacterial counts with the addition of 1% turmeric to chicken breast meat.

EXTRAÇÃO DE OLEORESINA DE CÚRCUMA (Curcuma longa L COM CO2 SUPERCRÍTICO

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A. Luis M. CHASSAGNEZ

1997-12-01

Full Text Available Dentre as fontes de corantes naturais mais utilizadas na indústria de alimentos, encontra-se a cúrcuma (Curcuma longa L, um rizoma do qual podem ser obtidas substâncias como a curcumina, demetoxicurcumina e bis-demetoxicurcumina. Estes pigmentos possuem coloração amarela e capacidade de substituir corantes artificiais. Com a finalidade de verificar a influência do pré-tratamento de secagem na extração, foram realizados experimentos de extração de oleoresina de cúrcuma com CO2 supercrítico, na unidade de extração do Laboratório de Engenharia Química da Universidade Federal do Pará, submetendo-se a matéria-prima a uma secagem nas temperaturas de 70 e 105oC. As extrações foram feitas a pressões de 200, 250 e 300 bar, e na temperatura de 45oC. Os resultados estão apresentados em tabelas e gráficos, em termos de rendimentos totais e teor de curcumina presente na oleoresina. A secagem a 70oC favoreceu a extração de oleoresina em termos de tempo de extração, e contribuiu para a manutenção de curcumina na matéria-prima.Turmeric (Curcuma longa L is one of the most used source of natural color in the food industry. Curcuminoids can be obtained from the roots of this plant. These pigments impact a yellow color and they might be able to substitute synthetic dyes. Turmeric oleoresin extraction experiments have been carried out with supercritical CO2 to investigate the influences of the pretreatment of the rhizomes on oleoresin. The extractions were conducted at the Department of Chemical Engineering of the Federal University of Pará (Universidade Federal do Pará. Turmeric was dried at 70ºC and 105ºC. Extractions have been carried out at pressures of 200, 250 and 300 bar and a temperature of 45ºC. Results shown the total yield and the content of curcumin present in the oleoresin. Amount of oleoresin extracted from the material dried at 70ºC was larger while most of the curcuminoids remained in the solid material.

Respuesta plástica a la luz y al agua en cuatro especies mediterráneas del género Quercus (Fagaceae Plastic response to light and water in four Mediterranean Quercus species (Fagaceae

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JOSÉ L QUERO

2008-09-01

Full Text Available La luz y el agua son dos de los principales factores que regulan el crecimiento y la supervivencia de las plantas leñosas mediterráneas. El objetivo de este estudio es conocer el nivel de respuesta plástica de plántulas de cuatro especies de Quercus a tratamientos de sombra y sequía. Además queremos evaluar qué variables son más plásticas a uno u otro factor, y probar la hipótesis de que los rasgos fisiológicos son más plásticos que los rasgos estructurales. Se cultivaron en condiciones controladas plántulas de Quercus ilex subsp. ballota, Q. súber, Q. pyrenaica y Q. canariensis en tres tratamientos de luz (100, 27 y 3 % de luz incidente y con agua abundante. A partir de mediados de primavera, a la mitad de las plántulas se les suprimió el agua, de forma que recibieron dos tratamientos de agua (riego versus no riego dentro de cada tratamiento de luz. Se analizaron distintos rasgos fisiológicos como la tasa de fotosíntesis y respiración, el punto de compensación y de saturación a la luz, la conductancia estomática, la eficiencia en el uso del agua y de nitrógeno y la eficiencia fotosintética a la luz. También se estudiaron distintos rasgos morfológicos o estructurales, como el área foliar, el área específica foliar, las concentraciones foliares de N y C, y un índice de clorofila. En general, la respuesta plástica de las variables estructurales al factor agua fue muy baja, mientras que la respuesta de las fisiológicas fue relativamente alta. Con la luz, no se detectaron diferencias significativas en la respuesta plástica entre las variables estructurales y fisiológicas. En estas especies de Quercus mediterráneos, la mayor respuesta plástica a la luz podría estar ligada con una estrategia de tolerancia a la sombra, mientras que la baja respuesta plástica al agua (i.e., canalización respondería a una estrategia de tolerancia a la sequía, indicando que la tolerancia a bajos niveles de recursos puede ser

Molecular cloning and characterization of novel phytocystatin gene from turmeric, Curcuma longa.

Science.gov (United States)

Chan, Seow-Neng; Abu Bakar, Norliza; Mahmood, Maziah; Ho, Chai-Ling; Shaharuddin, Noor Azmi

2014-01-01

Phytocystatin, a type of protease inhibitor (PI), plays major roles in plant defense mechanisms and has been reported to show antipathogenic properties and plant stress tolerance. Recombinant plant PIs are gaining popularity as potential candidates in engineering of crop protection and in synthesizing medicine. It is therefore crucial to identify PI from novel sources like Curcuma longa as it is more effective in combating against pathogens due to its novelty. In this study, a novel cDNA fragment encoding phytocystatin was isolated using degenerate PCR primers, designed from consensus regions of phytocystatin from other plant species. A full-length cDNA of the phytocystatin gene, designated CypCl, was acquired using 5'/3' rapid amplification of cDNA ends method and it has been deposited in NCBI database (accession number KF545954.1). It has a 687 bp long open reading frame (ORF) which encodes 228 amino acids. BLAST result indicated that CypCl is similar to cystatin protease inhibitor from Cucumis sativus with 74% max identity. Sequence analysis showed that CypCl contains most of the motifs found in a cystatin, including a G residue, LARFAV-, QxVxG sequence, PW dipeptide, and SNSL sequence at C-terminal extension. Phylogenetic studies also showed that CypCl is related to phytocystatin from Elaeis guineensis.

CURCUMA LONGA AS MEDICINAL HERB IN THE TREATMENT OF DIABET- IC COMPLICATIONS.

Science.gov (United States)

Karlowicz-Bodalska, Katarzyna; Han, Stanislaw; Freier, Julia; Smolenski, Michal; Bodalska, Agnieszka

2017-03-01

Curcuma longa L. (turmeric) of ginger family (Zingiberaceae) belongs to the group of oldest cultivated spice plants in the south-east Asian countries. For many years rhizome of this plant has been used also as a safe and active drug for the treatment of various.chronic diseases, especially of diabetes mellitus (DM). The active substance of turmeric - curcumin (diferuloylmethane), possesses multiple therapeutic properties. In recent years, many detailed research (tests in vito and in vivo) along with clinical trials have revealed its very valuable biological activities related to its anti-inflammatory, antioxidant and cancer preventive properties, which are presented in numerous publications (1-6). At the molecular level it has been stated that curcumin inhibits cell proliferation, metastasis creation and apoptosis. Currently, great attention has been focused on curcumin as a blocker of TNF-s, which are the principal mediators of most inflammation-related disturbances (7). The main cause of blocking the broadly extended pharmacological and clinical investigations of curcumin is its extremely low solubility in water and in organ fluids. This feature consequently limits its systemic bioavailability and makes use of curcumin as a therapeutic remedy (to date) difficult. The primary aim of presently conducted research is to achieve increased solubilization and bioavailability of this promising nontoxic agent.

Curcumin, an active component of turmeric (Curcuma longa), and its effects on health.

Science.gov (United States)

Kocaadam, Betül; Şanlier, Nevin

2017-09-02

Turmeric (Curcuma longa) is a type of herb belonging to ginger family, which is widely grown in southern and south western tropical Asia region. Turmeric, which has an importance place in the cuisines of Iran, Malesia, India, China, Polynesia, and Thailand, is often used as spice and has an effect on the nature, color, and taste of foods. Turmeric is also known to have been used for centuries in India and China for the medical treatments of illnesses such as dermatologic diseases, infection, stress, and depression. Turmeric's effects on health are generally centered upon an orange-yellow colored, lipophilic polyphenol substance called "curcumin," which is acquired from the rhizomes of the herb. Curcumin is known recently to have antioxidant, anti-inflammatory, anticancer effects and, thanks to these effects, to have an important role in prevention and treatment of various illnesses ranging notably from cancer to autoimmune, neurological, cardiovascular diseases, and diabetic. Furthermore, it is aimed to increase the biological activity and physiological effects of the curcumin on the body by synthesizing curcumin analogues. This article reviews the history, chemical and physical features, analogues, metabolites, mechanisms of its physiological activities, and effects on health of curcumin.

Una cohorte hispana en el desierto del Néguev, a la luz de un hallazgo reciente

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Figueras, Pau

2000-12-01

Full Text Available A fragmented statue with a bilingual inscription, found in the Negev desert, throws new light on the Roman military presence in the ancient Nabataean kingdom. The statue's features identify the Greek war goddess with the Nabataean goddess Alat. The Latin inscription mentions a soldier from the very little known Cohors VI Hispanorum.Una estatua fragmentaria con inscripción dedicatoria bilingüe, encontrada en el desierto del Néguev, arroja nueva luz sobre la presencia militar romana en el antiguo territorio nabateo. Por sus atributos, la estatua identifica a la diosa griega de la guerra con la diosa nabatea Alat. La parte latina de la inscripción menciona a un soldado de la muy poco conocida cohors VI Hispanorum.

Antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea and leaves of Annona muricata.

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Arroyo-Acevedo, Jorge; Franco-Quino, Cesar; Ruiz-Ramirez, Eliberto; Chávez-Asmat, Roberto; Anampa-Guzmán, Andrea; Raéz-González, Ernesto; Cabanillas-Coral, José

2016-01-01

Allergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. However, these drugs have many adverse effects. The use of medicinal plants could be an option, but they need to be evaluated. This study was designed to evaluate the antiallergic effect of the atomized extract of rhizome of Curcuma longa , flowers of Cordia lutea , and leaves of Annona muricata . Twenty-four New Zealand white albino rabbits were randomized into 2 groups. Group A received the atomized extract diluted in physiological saline (APS) and group B received it diluted in Freund's adjuvant (FA). Then, the back of each rabbit was divided into 4 quadrants. The A-I quadrant received only physiological saline. The A-I quadrants of each rabbit conformed the PS group. The following 3 quadrants received the APS in 10 μg/mL, 100 μg/mL, and 1,000 μg/mL, respectively. The B-I quadrant received only FA. The B-I quadrants of each rabbit conformed the FA group. The following 3 quadrants received the AFA in 10 μg/mL, 100 μg/mL, and 1,000 μg/mL, respectively. The occurrence of erythema and edema was recorded according to the Draize scoring system and the primary irritation index. After 72 hours, biopsies were performed. The AFA group presented significantly less erythema and edema compared to the FA group ( P <0.05). The histopathologic evaluation at 72 hours showed normal characteristics in the APS group. Considering the clinical and histopathological signs, we conclude that the administration of the atomized extract of rhizome of C. longa , flowers of C. lutea , and leaves of A. muricata lacks antigenic effect but could have an antiallergenic effect in a model of dermal irritation in rabbits.

Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba.

Science.gov (United States)

Yimam, Mesfin; Lee, Young-Chul; Moore, Breanna; Jiao, Ping; Hong, Mei; Nam, Jeong-Bum; Kim, Mi-Ran; Hyun, Eu-Jin; Chu, Min; Brownell, Lidia; Jia, Qi

2016-01-01

Though the initial etiologies of arthritis are multifactorial, clinically, patients share the prime complaints of the disease, pain. Here the authors assessed the analgesic and anti-inflammatory effects of UP1304, a composite that contains a standardized blend of extracts from the rhizome of Curcuma longa and the root bark of Morus alba, on rats with carrageenan-induced paw edema. A plant library was screened for bradykinin receptor antagonists. In vivo, the anti-inflammatory and analgesic effects of the standardized composite, UP1304, were evaluated in rats with carrageenan-induced paw edema using oral dose ranges of 100-400 mg/kg. Ibuprofen, at a dose of 200 mg/kg, was used as a reference compound. In vitro, cyclooxygenase (COX) and lipoxygenase (LOX) inhibition assays were performed to evaluate the degree of inflammation. Statistically significant improvements in pain resistance and paw edema suppression were observed in animals treated with UP1304, when compared to vehicle-treated rats. Results from the highest dose of UP1304 (400 mg/kg) were similar to those achieved by ibuprofen treatment at 200 mg/kg. In vitro, UP1304 showed dose-dependent inhibition of the enzymatic activities of COX and LOX. A half-maximal inhibitory concentration of 9.6 μg/mL for bradykinin B1 inhibition was calculated for the organic extract of C. longa. Curcumin showed Ki values of 2.73 and 58 μg/mL for bradykinin receptors B1 and B2, respectively. Data presented here suggest that UP1304, analgesic and anti-inflammatory agent of botanical origin, acted as a bradykinin receptor B1 and B2 antagonist, and inhibited COX and LOX enzyme activities. This compound should be considered for the management of symptoms associated with arthritis.

Distúrbios causados pelo frio e pelo calor durante corridas de longa distância

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1999-06-01

Full Text Available Muitos corredores amadores e de elite participam todos os anos de corridas de longa distância. Quando estes eventos ocorrem em temperaturas altas ou baixas, aumenta o risco de distúrbios térmicos. Contudo, a hipertermia induzida pelo exercício, a hipotermia, a desidratação e outros problemas relacionados podem ser minimizados através de esclarecimentos e um preparo antes do evento. Este documento fornece recomendações para o diretor médico e outras autoridades da organização das corridas nas seguintes áreas: planejamento, profissionais envolvidos na organização, instalações, suprimentos, equipamento e comunicação; fornecimento de esclarecimentos aos participantes; avaliação do estresse térmico; fornecimento de líquidos; e prevenção de questões legais em potencial. Este posicionamento oficial também descreve as condições predisponentes, as formas de diagnóstico e o tratamento dos quatro distúrbios ambientais mais comuns: exaustão pelo calor, colapso pelo calor, hipotermia e congelamento de extremidades. Os objetivos deste documento são: 1 Educar os organizadores e os participantes de corridas de longa distância a respeito das formas mais comuns de distúrbios térmicos incluindo as condições predisponentes, sinais de alerta, suscetibilidade e a redução de sua incidência; 2 Alertar os organizadores sobre as suas responsabilidades civis em potencial no que concerne à segurança do evento e à prevenção de lesões; 3 Recomendar que os organizadores consultem arquivos locais de meteorologia e planejem eventos em horas que provavelmente causem menos estresse térmico de modo a minimizar os efeitos deletérios sobre os participantes; 4 Estimular os organizadores a alertar os participantes sobre o estresse térmico no dia da corrida e as suas implicações no que tange aos distúrbios causados pelo frio e pelo calor; 5 Informar os organizadores sobre as ações preventivas que podem reduzir a incidência dos

The use of Curcuma longa extract to control Edwardsiella tarda infection on Clarias sp.

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Dinamella Wahjuningrum

2015-05-01

Full Text Available ABSTRACT  Target production of catfish in aquaculture can be reached by suppressing the pathogenic bacterial infection. Previous works had shown that turmeric Curcuma longa has antibacterial activity. The objectives of this research were to determine the best method of extraction and to evaluate the efficacy of turmeric extract as feed additive to control Edwardsiella tarda disease in catfish culture. Briefly, the objective was achieved through in vitro assay based on inhibition ability of extraction method against E. tarda, while the following objective was obtained through in vivo assay based on their survival during challenge test either as preventive or curative measurement. A complete randomized design with three replications was used for each assay. Furthermore, challenge test was done by mean intraperitoneal injection at concentration 106 cfu/mL of E. tarda (LD50. The results showed that 15 minutes decoction method allowed the best inhibition with diameter 7.42 mm of clear zone and then curative measurement using turmeric extract could be the best application against E. tarda since it gave 86.67% of survival. Clinical signs such as swelling, hemoraghic, body ulcer, gastroentritis and gaseous captivity were observed on challenged fish. However, there were no significant different among treatments for specific growth, body weight, and absolute length parameters.  Keywords: Edwardsiella tarda, extraction, turmeric, catfish, inhibition zone  ABSTRAK Peningkatan produksi ikan lele dapat dicapai melalui pencegahan infeksi penyakit bakterial. Hasil beberapa penelitian membuktikan bahwa kunyit Curcuma longa terbukti memiliki zat aktif yang bersifat antibakteri. Penelitian ini bertujuan untuk mencari metode ekstraksi terbaik dan mengevaluasi efektivitas penambahan ekstrak kunyit pada pakan untuk pengendalian patogen Edwardsiella tarda pada ikan lele. Metoda ekstraksi kunyit diuji secara in vitro dengan metoda zona hambat, sedangkan efikasi

Corpo, poder e o ato de partejar: reflexões à luz das relações de gênero

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Costa, Lúcia Helena Rodrigues

2000-01-01

O presente trabalho pretende contribuir com uma reflexão e discussão de alguns pontos sobre as questões relativas ao corpo feminino e o poder que perpassam o ato de partejar, compreendido este como o momento no qual através do trabalho do(a) outro(a), uma mulher "dá a luz".Discute a perspectiva da dominação masculina tomando como referência a violência simbólica em Bourdieu, propondo que a humanização do parto passa pelo aprofundamento da discussão da dominação de gênero, e não apenas do sexo...

USO DE PATRONES DE DIFRACCIÓN DE LUZ LÁSER Y ANÁLISIS DE IMAGENES PARA DIFERENCIACIÓN DE TRES TIPOS DE COLONIAS BACTERIANAS

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GLORIA ARANGO

2013-01-01

Full Text Available La diferenciación rápida de colonias bacterianas es esencial en muchos campos industriales, científicos y de salud humana y animal. Generalmente esa diferenciación se logra por técnicas microscópicas, bioquímicas o genéticas muy elaboradas que requieren tiempo y entrenamiento. En este estudio se utilizaron técnicas de análisis de imágenes sobre patrones de difracción de luz láser para evaluar su sensibilidad en la diferenciación de colonias bacterianas. Adicionalmente se estudió el efecto del tiempo de crecimiento de las colonias en la generación de estos patrones y se determinó la influencia de la cantidad de medio de cultivo en la difracción de luz láser. Los patrones de difracción del láser se obtuvieron sobre cultivos puros de cinco aislamientos bacterianos B1, B2, B3, B2Ca y B2Cb. En la primera prueba de diferenciación se utilizaron colonias de B2, B3, B2Ca. En el estudio del efecto del tiempo de crecimiento sobre patrones de difracción, las bacterias B1 y B2Cb con uno o dos días de crecimiento. Finalmente, el efecto de la cantidad de medio de cultivo en la difracción de la luz, se evaluó en una prueba en cajas petri con 10, 15 o 20 ml de medio de cultivo estéril sin colonias de bacterias. Mediante un análisis de escalado multidimensional realizado con los parámetros de textura extraídos de las imágenes de los patrones, se obtuvo un agrupamiento adecuado de los patrones asociados a las colonias de cada bacteria evaluada, lo cual indicó que las colonias bacterianas se pueden diferenciar por sus patrones de difracción. Adicionalmente se encontró que no hay variaciones significativas en los patrones de difracción obtenidos de dos aislamientos bacterianos en dos tiempos de crecimiento. El espesor del medio de cultivo afectó la difracción del haz de luz pues patrones obtenidos de cajas petri con 10 ml se separan completamente de los patrones obtenidos con 15 y 20 ml, aunque no hay diferencias entre los dos

Atividade de plasmina e plasminogênio no leite longa vida com alta e baixa contagem de células somáticas durante o armazenamento Activity of plasmin and plasminogen in ultra high temperature milk with high and low somatic cell counts during storage

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Carlos Humberto Corassin

2010-12-01

Full Text Available O objetivo deste estudo foi avaliar o efeito da contagem de células somáticas (CCS do leite na atividade de plasmina e plasminogênio durante o período de armazenamento do leite longa vida integral. Os leites crus foram categorizados em grupos de CCS de baixa (342.000-487.000 células mL-1 e alta contagem (603.000-808.000 células mL-1. Dois lotes de leite longa vida em cada categoria de CCS foram analisados para determinação de plasmina e plasminogênio após 10, 30, 60, 90 e 120 dias de armazenamento em temperatura ambiente. Para a fabricação do leite longa vida, o leite cru foi submetido à pasteurização rápida seguida da esterilização industrial do leite por injeção de vapor pelo método direto e embalagem asséptica do produto. A CCS não apresentou efeitos sobre as características físico-químicas do leite cru, e nem sobre a atividade de plasmina e plasminogênio nos leites cru e longa vida, armazenados por 120 dias. Entretanto, independentemente da CCS, a atividade de plasmina e plasminogênio aumentou no leite longa vida ao longo do armazenamento, indicando a possibilidade de aumento da proteólise no produto durante sua vida de prateleira.This study aimed to evaluate the effect of somatic cell counts (SCC in milk on plasmin and plasminogen activities of ultra high temperature (UHT milk during storage. Raw milks were categorized in SCC groups of low (342,000-487,000 cells mL-1 and high cells (603,000-808,000 cells mL-1. Two replicates of UHT milks within each SCC category were analyzed for plasmin and plasminogen activities after 10, 30, 60, 90 and 120 days of storage at room temperature. For manufacture of UHT milk, raw milk was pasteurized and sterilized by direct vapor injection process, followed by aseptic packaging. SCC had no effect on physical-chemical characteristics of raw milk, and on plasmin or plasminogen activities in raw and UHT milks during 120 days of storage. However, independently of the SCC in raw milk

Efecto de la temperatura y de la luz sobre la germinación de Nicotiana longiflora Cavaniles y Oenothera indecora Camb. Effect of temperature and the light on germination of Nicotiana longiflora Cavaniles and Oenothera indecora Camb.

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D. Faccini

2006-06-01

Full Text Available Nicotiana longiflora y Oenothera indecora son especies de reciente difusión en lotes agrícolas de la región pampeana argentina y se desconocen los factores ambientales que afectan su germinación. El objetivo de este trabajo fue determinar la influencia de la temperatura y de la luz sobre la germinación de ambas especies. Con temperaturas constantes la germinación fue mayor con luz entre los 20 y 35 °C para N. longiflora y entre 10 y 20 °C para O. indecora. Con temperaturas alternadas, N. longiflora presentó mayor germinación en un rango amplio rango con luz, y en oscuridad fue mayor sólo con 10-20 °C. O. indecora germinó sólo con luz en un amplio rango de temperaturas alternadas. La temperatura base en luz y en oscuridad fue de aproximadamente 14 °C para N. longiflora y de aproximadamente 6 °C para O. indecora. A partir de la temperatura base se puede inferir que N. longiflora es una especie con un ciclo de crecimiento primavero-estival y O. indecora otoño-primavero-estival.Nicotiana longiflora and Oenothera indecora are species of recent appearance in croplands in the Argentine humid pampa zone and there is a lack of knowledge about the environmental factors affecting their germination. The temperature and light requirements for germination and the base temperature of both species were determined. Under constant temperatures, germination was higher between 20 and 35 °C for N. longiflora and between 10 and 20 °C for O. indecora. Under fluctuating temperatures, N. longiflora showed higher germination rates in a wide range of temperatures with light. In darkness, germination was higher only between 10-20 °C for N. longiflora, whereas O. indecora germinated only with light, within a wide range of fluctuating temperatures. Base temperature under light and darkness conditions was approximately 14 °C for N. longiflora and approximately 6 °C for O. indecora. Base temperature indicates that N. longiflora is a species with a spring

Viabilidade econômica e tecnológica para a reciclagem das embalagens cartonadas longa vida pós-consumo de Porto Alegre

OpenAIRE

Rafael Batista Zortea

2001-01-01

O trabalho em questão tem como tema verificar a possibilidade do processo de reciclagem das embalagens longa vida pós-consumo geradas em Porto Alegre, baseando-se na infra-estrutura de gestão de resíduos existente na cidade e, em dados e informações de empresas de outras cidades que já começam a incorporar este tipo de resíduo como matériaprima em seus processos de reciclagem. A análise de alternativas, a fim de verificar a possibilidade da criação de recicladoras com o intuito de reaproveita...

Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells.

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Ooko, Edna; Kadioglu, Onat; Greten, Henry J; Efferth, Thomas

2017-01-01

Curcuma longa has long been used in China and India as anti-inflammatory agent to treat a wide variety of conditions and also as a spice for varied curry preparations. The chemoprofile of the Curcuma species exhibits the presence of varied phytochemicals with curcumin being present in all three species but AA only being shown in C. longa . This study explored the effect of a curcumin/AA combination on human cancer cell lines. The curcumin/AA combination was assessed by isobologram analysis using the Loewe additivity drug interaction model. The drug combination showed additive cytotoxicity toward CCRF-CEM and CEM/ADR5000 leukemia cell lines and HCT116p53 +/+ and HCT116p53 -/- colon cancer cell line, while the glioblastoma cell lines U87MG and U87MG.ΔEGFR showed additive to supra-additive cytotoxicity. Gene expression profiles predicting sensitivity and resistance of tumor cells to induction by curcumin and AA were determined by microarray-based mRNA expressions, COMPARE, and hierarchical cluster analyses. Numerous genes involved in transcription ( TFAM, TCERG1, RGS13, C11orf31 ), apoptosis-regulation ( CRADD, CDK7, CDK19, CD81, TOM1 ) signal transduction ( NR1D2, HMGN1, ABCA1, DE4ND4B, TRIM27 ) DNA repair ( TOPBP1, RPA2 ), mRNA metabolism ( RBBP4, HNRNPR, SRSF4, NR2F2, PDK1, TGM2 ), and transporter genes ( ABCA1 ) correlated with cellular responsiveness to curcumin and ascorbic acid. In conclusion, this study shows the effect of the curcumin/AA combination and identifies several candidate genes that may regulate the response of varied cancer cells to curcumin and AA.

A new species of Chaeridiona Baly (Coleoptera: Chrysomelidae: Cassidinae: Oncocephalini) infesting ginger Zingiber officinale Roscoe) and turmeric (Curcuma longa L.) in India and redescription of Chaeridiona pseudometallica Basu.

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Shameem, K M; Prathapan, K D

2014-06-17

Chaeridiona mayuri n. sp. infesting ginger (Zingiber officinale Roscoe) and turmeric (Curcuma longa L.) in southern India is described and illustrated. Cheilocostus speciosus ( J. Koenig) C. D. Specht, Globba sessiliflora Sims and Zingiber zerumbet (L.) Smith are reported as additional host plants. Chaeridiona pseudometallica Basu is redescribed and illustrated. A key to the species of Indian Chaeridiona is provided.

A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production.

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Uchio, Ryusei; Higashi, Yohei; Kohama, Yusuke; Kawasaki, Kengo; Hirao, Takashi; Muroyama, Koutarou; Murosaki, Shinji

2017-01-01

Turmeric ( Curcuma longa ) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury. This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW). Plasma levels of aspartate aminotransferase and alanine aminotransferase were markedly increased in ethanol-treated mice, while the increase of these enzymes was significantly suppressed by prior administration of WEC. The increase of alanine aminotransferase was also significantly suppressed by pretreatment with bisacurone. Compared with control mice, animals given WEC had higher hepatic tissue levels of superoxide dismutase and glutathione, as well as lower hepatic tissue levels of thiobarbituric acid-reactive substances, TNF-α protein and IL-6 mRNA. These results suggest that oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone.

Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats.

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Kim, Yongjae; You, Yanghee; Yoon, Ho-Geun; Lee, Yoo-Hyun; Kim, Kyungmi; Lee, Jeongmin; Kim, Min Soo; Kim, Jong-Choon; Jun, Woojin

2014-05-15

The hepatoprotective effect of fermented Curcuma longa L. (FC) was investigated in rats under CCl4-induced oxidative stress. FC at a dose of 30 or 300 mg/kg body weight (b.w.) was orally administered for 14 days followed by a single dose of CCl4 (1.25 mL/kg b.w. in 20% corn oil) on day 14. Pretreatment with FC drastically prevented the elevated activities of serum AST, ALT, LDH, and ALP caused by CCl4-induced hepatotoxicity. Histopathologically evident hepatic necrosis was significantly ameliorated by FC pretreatment. When compared to the CCl4-alone treated group, rats pretreated with FC displayed the reduced level of malondialdehyde. Furthermore, FC enhanced antioxidant capacities with higher activities of catalase, glutathione-S-transferase, glutathione reductase, and glutathione peroxidase, and level of reduced glutathione. These results suggest that FC could be a candidate used for the prevention against various liver diseases induced by oxidative stress via elevating antioxidative potentials and decreasing lipid peroxidation. Copyright © 2013 Elsevier Ltd. All rights reserved.

Effect of acidity on the energy level of curcumin dye extracted from Curcuma longa L.

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Agustia, Yuda Virgantara; Suyitno, Arifin, Zainal; Sutanto, Bayu

2016-03-01

The purpose of this research is to investigate the effect of acidity on the energy level of curcumin dye. The natural dye, curcumin, was synthesized from Curcuma longa L. using a simple extraction technique. The purification of curcumin dye was conducted in a column of chromatography and its characteristics were studied. Next, the purified curcumin dye was added by benzoic acids until various acidities of 3.0, 3.5, 4.0, 4.5, and 5.0. The absorbance spectra and the functionality groups found in the dyes were detected by ultraviolet-visible spectroscopy and Fourier-transform infrared spectroscopy, respectively. Meanwhile, the energy level of the dyes, EHOMO and ELUMO was measured by cyclic voltammetry. The best energy level of curcumin dye was achieved at pH 3.5 where Ered = -0.37V, ELUMO = -4.28 eV, Eox = 1.15V, EHOMO = -5.83 eV, and Eband gap = 1.55 eV. Therefore, the purified curcumin dye added by benzoic acid was promising for sensitizing the dye-sensitized solar cells.

Genetic diversity of turmeric germplasm (Curcuma longa; Zingiberaceae) identified by microsatellite markers.

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Sigrist, M S; Pinheiro, J B; Filho, J A Azevedo; Zucchi, M I

2011-03-09

Turmeric (Curcuma longa) is a triploid, vegetatively propagated crop introduced early during the colonization of Brazil. Turmeric rhizomes are ground into a powder used as a natural dye in the food industry, although recent research suggests a greater potential for the development of drugs and cosmetics. In Brazil, little is known about the genetic variability available for crop improvement. We examined the genetic diversity among turmeric accessions from a Brazilian germplasm collection comprising 39 accessions collected from the States of Goiás, Mato Grosso do Sul, Minas Gerais, São Paulo, and Pará. For comparison, 18 additional genotypes were analyzed, including samples from India and Puerto Rico. Total DNA was extracted from lyophilized leaf tissue and genetic analysis was performed using 17 microsatellite markers (single-sequence repeats). Shannon-Weiner indexes ranged from 0.017 (Minas Gerais) to 0.316 (São Paulo). Analyses of molecular variance (AMOVA) demonstrated major differences between countries (63.4%) and that most of the genetic diversity in Brazil is found within states (75.3%). Genotypes from São Paulo State were the most divergent and potentially useful for crop improvement. Structure analysis indicated two main groups of accessions. These results can help target future collecting efforts for introduction of new materials needed to develop more productive and better adapted cultivars.

Molecular Cloning and Characterization of Novel Phytocystatin Gene from Turmeric, Curcuma longa

Science.gov (United States)

Chan, Seow-Neng; Abu Bakar, Norliza; Mahmood, Maziah; Ho, Chai-Ling

2014-01-01

Phytocystatin, a type of protease inhibitor (PI), plays major roles in plant defense mechanisms and has been reported to show antipathogenic properties and plant stress tolerance. Recombinant plant PIs are gaining popularity as potential candidates in engineering of crop protection and in synthesizing medicine. It is therefore crucial to identify PI from novel sources like Curcuma longa as it is more effective in combating against pathogens due to its novelty. In this study, a novel cDNA fragment encoding phytocystatin was isolated using degenerate PCR primers, designed from consensus regions of phytocystatin from other plant species. A full-length cDNA of the phytocystatin gene, designated CypCl, was acquired using 5′/3′ rapid amplification of cDNA ends method and it has been deposited in NCBI database (accession number KF545954.1). It has a 687 bp long open reading frame (ORF) which encodes 228 amino acids. BLAST result indicated that CypCl is similar to cystatin protease inhibitor from Cucumis sativus with 74% max identity. Sequence analysis showed that CypCl contains most of the motifs found in a cystatin, including a G residue, LARFAV-, QxVxG sequence, PW dipeptide, and SNSL sequence at C-terminal extension. Phylogenetic studies also showed that CypCl is related to phytocystatin from Elaeis guineensis. PMID:25853138

Molecular Cloning and Characterization of Novel Phytocystatin Gene from Turmeric, Curcuma longa

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Seow-Neng Chan

2014-01-01

Full Text Available Phytocystatin, a type of protease inhibitor (PI, plays major roles in plant defense mechanisms and has been reported to show antipathogenic properties and plant stress tolerance. Recombinant plant PIs are gaining popularity as potential candidates in engineering of crop protection and in synthesizing medicine. It is therefore crucial to identify PI from novel sources like Curcuma longa as it is more effective in combating against pathogens due to its novelty. In this study, a novel cDNA fragment encoding phytocystatin was isolated using degenerate PCR primers, designed from consensus regions of phytocystatin from other plant species. A full-length cDNA of the phytocystatin gene, designated CypCl, was acquired using 5′/3′ rapid amplification of cDNA ends method and it has been deposited in NCBI database (accession number KF545954.1. It has a 687 bp long open reading frame (ORF which encodes 228 amino acids. BLAST result indicated that CypCl is similar to cystatin protease inhibitor from Cucumis sativus with 74% max identity. Sequence analysis showed that CypCl contains most of the motifs found in a cystatin, including a G residue, LARFAV-, QxVxG sequence, PW dipeptide, and SNSL sequence at C-terminal extension. Phylogenetic studies also showed that CypCl is related to phytocystatin from Elaeis guineensis.

DISPONIBILIDAD DE LUZ Y PRODUCCIÓN DE NUEZ DESPUÉS DEL ACLAREO DE ÁRBOLES DE NOGAL PECANERO (Carya illinoensis

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J. G. Arreola Ávila

2010-01-01

Full Text Available El volumen de la copa bien iluminada es uno de los factores clave en la productividad de árboles de nogal pecanero. Cuando las huertas de nogal pecanero con densidades de plantación al menos de 100 árboles por hectárea presentan problemas de sombreo, la penetración de luz dentro de la copa del árbol y entre árboles, el crecimiento y la producción son negativamente afectadas. La investigación realizada para estudiar el efecto del aclareo de árboles de nogal pecanero sobre la disponibilidad de la luz y productividad de la huerta es limitada. El objetivo del presente estudio fue determinar el efecto del aclareo de árboles sobre la disponibilidad de radiación fotosintéticamente activa (RFA dentro de árboles permanentes, crecimiento del brote, producción y calidad de la nuez. Este estudio se llevó a cabo en una huerta madura de nogal pecanero con aclareo de árboles de 25 a 50 % durante el periodo 2004-2008. La disponibilidad de RFA dentro de árboles, longitud de brotes y la producción de nuez fueron afectadas por los tratamientos de aclareo; sin embargo, la calidad (porcentaje de almendra por árbol durante el periodo de tres años de estudio no fue significativamente afectada. Los resultados de este estudio indican que un gradual aclareo en huertas con problemas de sombreo debe realizarse para recuperar el crecimiento y componentes de producción.

The genome-wide expression profile of Curcuma longa-treated cisplatin-stimulated HEK293 cells

Science.gov (United States)

Sohn, Sung-Hwa; Ko, Eunjung; Chung, Hwan-Suck; Lee, Eun-Young; Kim, Sung-Hoon; Shin, Minkyu; Hong, Moochang; Bae, Hyunsu

2010-01-01

AIM The rhizome of turmeric, Curcuma longa (CL), is a herbal medicine used in many traditional prescriptions. It has previously been shown that CL treatment showed greater than 47% recovery from cisplatin-induced cell damage in human kidney HEK 293 cells. This study was conducted to evaluate the recovery mechanisms of CL that occur during cisplatin induced nephrotoxicity by examining the genome wide mRNA expression profiles of HEK 293 -cells. METHOD Recovery mechanisms of CL that occur during cisplatin-induced nephrotoxicity were determined by microarray, real-time PCR, immunofluorescent confocal microscopy and Western blot analysis. RESULTS The results of microarray analysis and real-time PCR revealed that NFκB pathway-related genes and apoptosis-related genes were down-regulated in CL-treated HEK 293 cells. In addition, immunofluorescent confocal microscopy and Western blot analysis revealed that NFκB p65 nuclear translocation was inhibited in CL-treated HEK 293 cells. Therefore, the mechanism responsible for the effects of CL on HEK 293 cells is closely associated with regulation of the NFκB pathway. CONCLUSION CL possesses novel therapeutic agents that can be used for the prevention or treatment of cisplatin-induced renal disorders. PMID:20840446

Qualidade fisiológica de sementes de guanxuma em influência do envelhecimento acelerado e da luz = Influence of accelerated aging and light on the physiological quality of arrowleaf sida seeds

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Denise Bruginski de Carvalho

2009-07-01

Full Text Available O objetivo deste trabalho foi determinar o efeito do envelhecimento acelerado e da presença da luz na qualidade fisiológica de sementes de guanxuma (Sida rhombifolia L.. Foram estudados quatro tempos de envelhecimento acelerado (0, 24, 48 e 72h e a presença ou ausência de luz no teste de germinação. O delineamento experimental adotado foi em blocos casualizados num esquema fatorial 4 x 2, com três repetições. Adotou-se o método de germinação sobre papel em caixa de plástico (Gerbox à temperatura de 25°C. Analisaram-se as variáveis porcentagem de germinação, índice de velocidade de germinação(IVG, tempo médio para germinação (TMG, velocidade média de germinação (VMG e entropia. As avaliações foram realizadas durante 63 dias após a instalação do teste. A ausência de luz favoreceu a germinação e o IVG das sementes de guanxuma. O TMG e a entropiadiminuíram e a VMG aumentou com o aumento do tempo de envelhecimento acelerado e não foram influenciados pela luz. Na presença de luz, a germinação e o IVG foram reduzidos com tempos de envelhecimento acelerado mais longos. Conclui-se que o envelhecimento acelerado de sementes de guanxuma por até 72h proporcionou aumento na qualidade fisiológica das sementes submetidas à germinação no escuro.The objective of this study was to determine the effect ofaccelerated aging and presence of light on the physiological quality of arrowleaf sida (Sida rhombifolia L. seeds. Four accelerated aging times (0, 24, 48 and 72 hours, as well as the presence or absence of light during germination test, were evaluated by using a randomizedblock design, with a 4 x 2 factorial scheme and three replications. Seeds were germinated in germination boxes (Gerbox lined with paper, at 25°C. The variables analyzed were: germination percentage, germination speed index (GSI, average germination time (AGT,average germination speed (AGS and entropy. Evaluations were made 63 days after installation

Corpo, poder e o ato de partejar: reflexões à luz das relações de gênero

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Lúcia Helena Rodrigues Costa

2000-03-01

Full Text Available O presente trabalho pretende contribuir com uma reflexão e discussão de alguns pontos sobre as questões relativas ao corpo feminino e o poder que perpassam o ato de partejar, compreendido este como o momento no qual através do trabalho do(a outro(a, uma mulher "dá a luz".Discute a perspectiva da dominação masculina tomando como referência a violência simbólica em Bourdieu, propondo que a humanização do parto passa pelo aprofundamento da discussão da dominação de gênero, e não apenas do sexo ou da profissão de quem parteja.

Resolução de conflitos em centros integrados de cidadania: uma abordagem à luz da perspectiva sociotécnica de grupos de trabalho

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Almir Cordeiro Júnior

Full Text Available Por meio da análise do modelo de Centro Integrado de Cidadania, implantado em Vitória, e dos equipamentos que o antecederam, busca-se, neste artigo: identificar os serviços que devem estar presentes num equipamento urbano dessa natureza, à luz dos instrumentos governamentais que originaram sua concepção; categorizar os serviços identificados segundo algumas das principais classificações existentes na literatura específica (Chase, 1978; Lovelock, 1983; Schmenner, 1986; discutir as unidades de atendimento como integrantes de um processo de produção induzido pelo cliente, à luz das estruturas básicas propostas por Wild (1977; direcionar o foco da abordagem para as unidades que estão voltadas à resolução pacífica de conflitos, confrontando seus subsistemas técnico e social com os pressupostos da Escola Sociotécnica (Biazzi Júnior, 1994; comparar a atuação dessas unidades com o job design para grupos semiautônomos (Cherns, 1994 e, por fim, comentar a importância da estruturação dessas unidades como grupos autogeridos, mostrando que esta abordagem contribui sobremaneira para a integração operacional e a gestão dessas unidades.

Influencia de la luz privada doméstica sobre la fuente de la contaminación lumínica

OpenAIRE

García Gil, Manuel; González Dorta, Naiara

2016-01-01

Desde el inicio de su estudio más severo, en los años setenta, todos los esfuerzos sobre la contaminación lumínica en la ciudad, se han centrado fundamentalmente en la reducción del flujo contaminante emitido por las luminarias de alumbrado público. Con este trabajo se desvía el punto de atención hacia el análisis de las fuentes de luz privada doméstica, con ello se espera abrir nuevas vías de investigación y ampliar el conocimiento sobre el problema dentro de las ciudades.Se plantea el análi...

Effect of Turmeric Etanol Extract (Curcuma Longa L) on Low Density Lipoprotein Level and Liver Histopathology Image in Type 1 Diabetes Mellitus Rat Model Induced by Streptozotocin

OpenAIRE

Herlina Pratiwi; Djoko Winarso; Nunung Handoyo

2017-01-01

This study was conducted to determine levels of LDL and liver damage in rats (Rattus norvegicus) models of type 1 diabetes mellitus inducted by streptozotocin (STZ) with etanol extract of turmeric (Curcuma Longa L) therapy. Animals used rat (Rattus norvegicus) 3-month-old males who were divided into 5 groups, each group consisting of four mice. The group was divided according to treatment: negative control (not induced by STZ), the positive control group (STZ induced), groups of rats DM 1 wit...

Garrafas de PET para óleo comestível: avaliação da barreira à luz PET bottles for edible oil packaging: evaluation of the light barrier

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Leda Coltro

2004-09-01

Full Text Available Os óleos comestíveis são produtos alimentícios sensíveis à luz, pois estão sujeitos à degradação por foto-oxidação, cujas conseqüências são escurecimento do produto e alteração de aroma e sabor, levando à rejeição do produto. Assim, quando os óleos são acondicionados em embalagens transparentes, a foto-oxidação torna-se a principal causa da deterioração oxidativa devido ao efeito da luz, encurtando a vida-de-prateleira do produto e daí surgindo a necessidade da utilização de absorvedores de UV, substâncias incolores que, quando incorporadas ao material da embalagem, absorvem a energia UV incidente ou inativam cromóforos excitados protegendo o produto. Este estudo foi desenvolvido com o objetivo de avaliar a barreira à luz de embalagens de PET disponíveis no mercado brasileiro utilizadas para o acondicionamento de óleo comestível por meio da obtenção de espectros de transmissão de luz especular no UV-Visível. As embalagens que apresentaram barreira à luz foram submetidas a ensaios analíticos com a finalidade de identificação e quantificação do aditivo utilizado. Os aditivos absorvedores de UV identificados nas embalagens plásticas foram relacionados quanto à restrição de uso e limites de composição estabelecidos pela Resolução 105 da Agência Nacional de Vigilância Sanitária - ANVISA. Com isso foi possível fazer um diagnóstico do uso de absorvedores de UV em embalagens de PET utilizadas para o acondicionamento de óleo comestível disponíveis no mercado brasileiro.The edible oils are light sensitive food products since they degrade by photo-oxidation, which promotes darkening of the product, alteration of its flavor and consequently its rejection. For edible oils packed in transparent packages, photo-oxidation becomes the main cause of the oxidative deterioration due to the light effect, reducing the shelf-life of the product. Then, it is necessary to use UV absorbers, colorless substances

Efeito do tratamento clínico de um corredor de longa distância com broncoespasmo induzido pelo exercício: relato de caso

OpenAIRE

Teixeira,Renata Nakata; Gonçalves,Raquel Calvo; Costa,Luiz Augusto Riani; Silva,Leonardo Borges de Barros e; Martins,Milton de Arruda; Teixeira,Luzimar Raimundo; Carvalho,Celso Ricardo Fernandes

2009-01-01

O broncoespasmo induzido pelo exercício (BIE) é uma condição que se caracteriza pelo estreitamento transitório das vias aéreas durante ou após o esforço físico e afeta principalmente portadores de asma. Em atletas profissionais que praticam esportes de alta intensidade, a prevalência também é alta; no entanto, seu diagnóstico permanece subestimado. O presente estudo descreve o caso de um atleta do sexo masculino, 23 anos, corredor de longa distância sem histórico de asma, que após um teste gr...

Newton versus Huygens: como (não ocorreu a disputa entre suas teorias para a luz

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Breno Arsioli Moura

2016-04-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2016v33n1p111 Este artigo apresenta uma análise crítica da possível disputa entre as teorias sobre luz e cores elaboradas por Newton e Huygens que teria ocorrido entre os séculos XVII e XIX. Com base em diversos estudos historiográficos já realizados sobre o tema, será mostrado que na Historiografia da Ciência a ideia de uma disputa entre as ópticas de Newton e Huygens é considerada ultrapassada. O artigo fornece um apanhado histórico da Óptica no período, oferecendo subsídios para que essa questão seja também problematizada no Ensino, assim como foi na Historiografia da Ciência atual.

O Plano Real à luz da experiência mexicana e argentina

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Paulo Nogueira Batista Jr.

1996-12-01

Full Text Available O trabalho discute os primeiros dois anos do Plano Real e em especial os seus efeitos sobre as relações externas do Brasil, à luz da experiência de programas de estabilização adotados no México, em 1988-1994, e na Argentina, desde 1991. Embora cada experiência nacional apresente as suas peculiaridades, argumenta-se que a economia brasileira vem revivendo a experiência mexicana e argentina em alguns pontos importantes, combinando sucesso no combate à inflação com acentuada e persistente apreciação cambial, elevados déficits no balanço de pagamentos em conta corrente e dependência de fluxos voláteis de capital internacional.This paper discusses the first two years of Brazil's current stabilization programme - known as the Real Plan - and in particular its effects on the country's external economic relations, in the ligth of similar stabilization programmes adopted in Mexico from 1988 to 1994 and in Argentina since 1991. Although each national experience has its peculiarities, it is shown that the Brazilian economy has been reliving the Mexican and Argentinian experience in some important respects, combining success in terms of inflation reduction, with strong and persistent exchange rate appreciation, high deficits in the balance of payments on current account and dependence on volatile international capital flows.

Relato de caso: implante transparietohepático de cateter de longa permanência para diálise Case report: transhepatic insertion of long-term dialysis catheter

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Felipe Nasser

2007-12-01

Full Text Available O implante transhepático de cateteres de diálise de longa permanência é um procedimento de exceção, utilizado para obter um acesso em pacientes com oclusão de veias centrais de membros superiores e inferiores. O caso descrito relata um paciente jovem, com história de 15 anos de diálise, que foi submetido no passado a um transplante renal sem sucesso. Esse paciente encontrava-se em urgência dialítica e oclusão comprovada de veias centrais de membros superiores e de veias ilíacas. Foi realizado o implante do cateter de longa permanência pelo acesso transparietohepático sob anestesia geral. A ponta do cateter foi posicionada ao nível do átrio direito. A diálise foi realizada satisfatoriamente no mesmo dia.Transhepatic insertion of long-term dialysis catheter is an exception procedure used to obtain access in patients with central vein occlusion of lower and upper limbs. We report on a case of a young patient with history of dialysis for 15 years, who was submitted to an unsuccessful renal transplantation. This patient was in dialytic emergency and had confirmed occlusion of upper limb central veins and iliac veins. Transhepatic insertion of a long-term catheter was performed under general anesthesia. The catheter tip was placed at the level of the right atrium. Dialysis was satisfactorily performed on the same day.

Viagens “independentes” de longa duração: política, economia e cultivo da mobilidade

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Igor Monteiro Silva

2016-08-01

Full Text Available As viagens “independentes” de longa duração são caracterizadas, por seus praticantes, a partir da distinção frente às “práticas turísticas institucionalizadas”. Enquanto os primeiros buscam uma experiência de deslocamento mais alargada em termos espaciais e temporais, priorizando o contato íntimo com as comunidades visitadas e demais viajantes, os turistas – segundo os termos desse segmento conhecido popularmente como mochileiro ou backpacker – resignam-se ao abrigo de um tipo de “bolha ambiental”, não prescindindo em suas viagens das mediações de agências e guias. A presente comunicação objetiva, justamente, explorar este universo de práticas e sentidos construído pelos sujeitos das viagens “independentes”, procurando compreender, mais detidamente, a relação estabelecida entre estes viajantes e suas comunidades de origem.

AVALIAÇÃO DA FUNÇÃO PULMONAR EM IDOSOS TABAGISTAS DE LONGA DATA ATIVOS E INSTITUCIONALIZADOS

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Nelson Coimbra RIBEIRO NETO

2016-06-01

Full Text Available Um importante acometimento decorrente do tabagismo é a doença pulmonar obstrutiva crônica (DPOC, que é reconhecida como importante problema de saúde pública. Para tal, esta pesquisa teve a pretensão de avaliar a função pulmonar em idosos tabagistas de longa data ativos e institucionalizados, por meio de um estudo de campo, exploratório e quantitativo, realizado no Clube da Amizade de Castelo (CLAC e no Lar Vila Feliz, ambos localizados no município de Castelo-ES. Foram formados 2 grupos com N=4 em cada, constituindo um grupo de idosos ATIVOS e outro de idosos ITT (institucionalizados. Os dados coletados nos testes de espirometria e manovacuometria foram tabulados e analisados estatisticamente, adotando-se valor de p<0,05. Não foram observadas diferenças significativas entre as amostras, o que não descarta a necessidade de novas e mais amplas pesquisas na área.

Determination of Curcuminoids in Curcuma longa Linn. by UPLC/Q-TOF-MS: An Application in Turmeric Cultivation.

Science.gov (United States)

Ashraf, Kamran; Mujeeb, Mohd; Ahmad, Altaf; Ahmad, Niyaz; Amir, Mohd

2015-09-01

Cucuma longa Linn. (Fam-Zingiberaceae) is a valued medicinal plant contains curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) as major bioactive constituents. Previously reported analytical methods for analysis of curcuminoids were found to suffer from low resolution, lower sensitivity and longer analytical times. In this study, a rapid, sensitive, selective high-throughput ultra high performance liquid chromatography-tandem mass spectrometry (UPLC/Q-TOF-MS) method was developed and validated for the quantification of curcuminoids with an aim to reduce analysis time and enhance efficiency. UPLC/Q-TOF-MS analysis showed large variation (1.408-5.027% w/w) of curcuminoids among different samples with respect to their occurrence of metabolite and their concentration. The results showed that Erode (south province) contains highest quantity of curcuminoids and concluded to be the superior varieties. The results obtained here could be valuable for devising strategies for cultivating this medicinal plant. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Efeito de substratos, luz e sobreposição de papel de filtro na esporulação de Corynespora cassiicola Effect of substrates, light and filter paper on Corynespora cassiicola sporulation

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Márcia Muliterno de Melo

2010-09-01

Full Text Available O experimento foi realizado no Laboratório de Fitopatologia - Micologia, na Faculdade de Agronomia e Medicina Veterinária da Universidade de Passo Fundo, com a finalidade de avaliar a esporulação de Corynespora cassiicola em diferentes substratos. Para isso foram usadas placas de petri com seis diferentes meio de cultura - Batata Dextrose Ágar (BDA, Solução Czapek Ágar, Alimento infantil, Malte Ágar, Farinha de aveia e suco V8 Ágar e quatro combinações (com luz alternada e sobreposição de papel filtro, com luz alternada e sem sobreposição de papel filtro, sem luz com sobreposição de papel filtro e sem luz e sem sobreposição de papel filtro. O delineamento experimental usado foi fatorial triplo (substrato, luz/escuro, com ou sem sobreposição de papel filtro. Na avaliação de esporulação do fungo, foram cortados dois discos de 0,241cm² em cada placa dos diferentes substratos e colocados em tubos de ensaio contendo 10mL de água destilada. Esses tubos foram agitados e de cada um foram retiradas três alíquotas de 10mL para contagem de conídios no microscópio óptico. Os dados foram transformados em número de esporos.cm². A maior esporulação do fungo foi obtida com o substrato Solução Czapek-Ágar, com fotoperíodo de 12 horas e sobreposição de papel filtro.This experiment was carried out in the Laboratory of Phytopathology - Mycology - School of Agronomy and Veterinary Medicine, Passo Fundo University, in order to evaluate Corynespora cassiicola sporulation on different substrates. Thus the used Petri plates contained six different culture media - Potato Dextrose Agar (PDA, Czapek Solution Agar, infant food, Malt Agar, Oatmeal Agar, and V8 juice agar, besides four combinations (with both light and filter paper, with light and without filter paper, with filter paper and without light, and without light and without filter paper. Experimental design was triple factorial (substrate, light / dark, with or without

Attenuation of gentamycin-induced nephrotoxicity in rats by dietary inclusion of ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes.

Science.gov (United States)

Ademiluyi, Adedayo O; Oboh, Ganiyu; Ogunsuyi, Opeyemi B; Akinyemi, Ayodele J

2012-10-01

This study sought to investigate the modulatory effects of dietary inclusion of ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes on antioxidant status and renal damage induced by gentamycin in rats. Renal damage was induced in albino rats pretreated with dietary inclusion of ginger and turmeric (2% and 4%) by intraperitoneal (i.p.) administration of gentamycin (100 mg/kg body weight) for three days. Assays for renal damage biomarkers (plasma creatinine, plasma urea, blood urea nitrogen and plasma uric acid), malondialdehyde (MDA) content and reduced glutathione (GSH) content as well as renal antioxidant enzymes (catalase, glutathione-S-transferase (GST), glutathione peroxidase (GPx) and superoxide dismutase (SOD)) were carried out. The study revealed significant (p turmeric rhizome (2% and 4%) prior to gentamycin administration significantly (p turmeric rhizomes may protect against gentamycin-induced nephrotoxicity and oxidative stress.

Monumento Estela de Luz: disputas en torno a los usos públicos de la historia en el México del Bi/Centenario

OpenAIRE

Sebastián Vargas Álvarez

2016-01-01

Este artículo parte de la premisa de que actualmente es imprescindible para los historiadores reconocer la importancia de la vida pública y de los usos públicos de la historia, e involucrarse activamente en los debates sobre la representación del pasado en contextos que exceden la práctica disciplinar y los espacios académicos. Para ello, se propone un caso de estudio concreto: la Estela de Luz, monumento erigido en México, en el 2010, ocasión del Bicentenario de la Independencia y Centenario...

APLICACIÓN DE LA FOTOCATÁLISIS OXIDATIVA CON ZnO Y LUZ SOLAR PARA EL TRATAMIENTO DE AGUA CONTAMINADA CON COLORANTES INDUSTRIALES

OpenAIRE

ORTIZ ROMERO, DERLY DAVID

2016-01-01

RESUMEN El presente estudio tuvo como objetivo aplicar la fotocatálisis oxidativa con ZnO como fotocatalizador y luz solar para el tratamiento de agua contaminada con colorantes industriales. Para este fin; se validaron las técnicas analíticas necesarias para efectuar la investigación en los colorantes Amarillo Oro K–2R, Ácido Carmínico y Rodamina B; los métodos mostraron respuesta lineal, sensible y precisa para los tres colorantes; asimismo se realizó monitorización de la intensidad de...

Regime de luz em uma floresta estacional semidecídua sob manejo, em Pirenópolis, Goiás

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Fábio Venturoli

2012-12-01

Full Text Available Esta pesquisa foi realizada em um fragmento de floresta estacional semidecídua, localizada em Pirenópolis, Goiás, e investigou as alterações no regime de luz, medida pela densidade de fluxo de fótons, associadas a intervenções silviculturais que visaram, sobretudo, aumentar o crescimento de espécies arbóreas, sem permitir a invasão por espécies oportunistas que poderiam influenciar negativamente a dinâmica da regeneração natural. O delineamento foi em blocos casualizados, em esquema fatorial, testando as diferenças entre tratamentos silviculturais, estações climáticas e alturas de medida no sub-bosque (1,30 m e ao nível do solo. Foram testadas duas intensidades de corte seletivo de indivíduos arbóreos e de cipós na floresta. Os tratamentos foram suficientes para alterar o regime de luz, tanto na estação seca como na estação chuvosa, em acordo com a hipótese testada. O sombreamento na área controle foi de 97% na estação chuvosa e de 86% na estação seca, apresentando diferenças significativas com o sombreamento associado aos tratamentos silviculturais, que variaram de 93% a 94% na chuva e de 77% a 80% na seca. Esse estudo pode auxiliar na validação deste sistema de manejo florestal proposto para as florestas estacionais semidecíduas no Brasil Central, devendo ser associado aos estudos populacionais e de comunidade, preservando os fragmentos florestais encontrados na região e gerando benefícios ambientais e renda extra para a população rural.

Desarrollo de una interfaz gráfica para un sistema electrónico de caracterización óptica de diodos emisores de luz

OpenAIRE

Colino Barrigón, Juan José

2015-01-01

En este Trabajo de Fin de Grado (TFG) se describe el proceso de análisis, diseño y desarrollo de una interfaz gráfica para un sistema de caracterización óptica de diodos emisores de luz (LED del inglés Light-emitting diode). La interfaz ha sido implementada en Python usando la librería gráfica GTK+3 para Linux. Grado en Ingeniería Informática

Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.

Science.gov (United States)

Kitabatake, Tomoko; Tabo, Hiromi; Matsunaga, Hisami; Haginaka, Jun

2013-08-01

A monodisperse molecularly imprinted polymer (MIP) for curcumin was first prepared by precipitation polymerization using methacrylamide (MAM) and 4-vinylpyridine as functional co-monomers, divinylbenzene as a crosslinker, and a mixture of acetonitrile and toluene as a porogen. The use of MAM as the co-monomer resulted in the formation of a monodisperse MIP and non-imprinted polymer (NIP). MIP and NIP, respectively, were monodispersed with a narrow particle size distribution (3.3 ± 0.09 and 3.5 ± 0.10 μm). In addition to shape recognition, hydrophobic and hydrogen-bonding interactions affected the retention and molecular-recognition of curcumin on the MIP. The MIP for curcumin could extract curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in Curcuma longa L.

O DIREITO FUNDAMENTAL À MORADIA COMO MÍNIMO EXISTENCIAL, E A SUA EFETIVAÇÃO À LUZ DO ESTATUTO DA CIDADE

OpenAIRE

Rangel, Helano Márcio Vieira; Universidade Federal do Ceará (UFC); Silva, Jacilene Vieira da; Faculdade Estácio do Ceará

2011-01-01

O presente ensaio analisa o direito à moradia à luz da constitucionalização e repersonalização do Direito Civil, por meio de um enfoque específico sobre o princípio da dignidade da pessoa humana e da função social da propriedade. O objetivo primário da pesquisa é o de demonstrar o direito à moradia como um direito humano consagrado internacionalmente, assim como um direito fundamental social indispensável à composição de um mínimo existencial para uma vida digna. A pesquisa buscou ainda eluci...

Calibración de un sistema electrónico para la caracterización óptica de diodos emisores de luz

OpenAIRE

Vara Lubiano, Mónica

2017-01-01

El objetivo de este trabajo es la calibración de un sistema electrónico capaz de automatizar la obtención de espectros de emisión de fuentes de luz. Se trata de obtener una medida de la irradiancia de la fuente, es decir, potencia suministrada por la misma por unidad de superficie y para cada longitud de onda. En primer lugar se calibró la medida de la longitud de onda. Éste proceso consistió en la comparaci ón directa del espectro obtenido por el sistema con el valor conocido ...

Effect of acidity on the energy level of curcumin dye extracted from Curcuma longa L

Energy Technology Data Exchange (ETDEWEB)

Agustia, Yuda Virgantara, E-mail: yuda.mechanical.engineer@student.uns.ac.id; Suyitno,, E-mail: suyitno@uns.ac.id; Sutanto, Bayu, E-mail: bayu.sutanto@student.uns.ac.id [Department of Mechanical Engineering, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta (Indonesia); Arifin, Zainal, E-mail: zainal-a@uns.ac.id [Department of Mechanical Engineering, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta (Indonesia); Department of Mechanical Engineering, Brawijaya University, Malang (Indonesia)

2016-03-29

The purpose of this research is to investigate the effect of acidity on the energy level of curcumin dye. The natural dye, curcumin, was synthesized from Curcuma longa L. using a simple extraction technique. The purification of curcumin dye was conducted in a column of chromatography and its characteristics were studied. Next, the purified curcumin dye was added by benzoic acids until various acidities of 3.0, 3.5, 4.0, 4.5, and 5.0. The absorbance spectra and the functionality groups found in the dyes were detected by ultraviolet-visible spectroscopy and Fourier-transform infrared spectroscopy, respectively. Meanwhile, the energy level of the dyes, E{sub HOMO} and E{sub LUMO} was measured by cyclic voltammetry. The best energy level of curcumin dye was achieved at pH 3.5 where E{sub red} = −0.37V, E{sub LUMO} = −4.28 eV, E{sub ox} = 1.15V, E{sub HOMO} = −5.83 eV, and E{sub band} {sub gap} = 1.55 eV. Therefore, the purified curcumin dye added by benzoic acid was promising for sensitizing the dye-sensitized solar cells.

In vitro effectiveness of Curcuma longa and Zingiber officinale extracts on Echinococcus protoscoleces.

Science.gov (United States)

Almalki, Esam; Al-Shaebi, Esam M; Al-Quarishy, Saleh; El-Matbouli, Mansour; Abdel-Baki, Abdel-Azeem S

2017-01-01

Hydatid disease is an important economic and human public health problem with a wide geographical distribution. Surgical excision remains the primary treatment and the only hope for complete cure of hydatosis. The most important complications arising from surgical excision, however, is recurrence, which is due to dissemination of protoscolices during the surgery. Pre-surgical inactivation of the contents of the hydatid cyst by injection of scolicidal agent into the cyst has been used as adjunct to surgery in order to overcome the risk of recurrence. In the present study, ethanolic extracts of turmeric ( Curcuma longa ) and ginger ( Zingiber officinale ) were tested as scolicidal agent for Echinococcus protoscoleces. Protoscoleces were collected aseptically from sheep livers containing hydatid cysts. Three concentrations (10, 30 and 50 mg/ml) of each extract were investigated and viability of the protoscoleces was tested by 0.1% eosin staining. Ginger extract showed the strongest scolicidal effect (100%) after 20 min at a concentration of 30 mg/ml and 10 min at 50 mg/ml . The maximum scolicidal effect of turmeric was 93.2% after 30 min at a concentration of 50 mg/ml. It is concluded that turmeric and ginger extracts have high scolicidal activity and could be used as effective scolicidal agents against Echinococcus protoscoleces.

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review.

Science.gov (United States)

Soleimani, Vahid; Sahebkar, Amirhossein; Hosseinzadeh, Hossein

2018-02-26

Curcumin is the major constituent of turmeric (Curcuma longa). Turmeric has been widely used as a spice in foods and for therapeutic applications such as anti-inflammatory, antihyperlipidemic, and antimicrobial activities. Turmeric and curcumin are nonmutagenic and nongenotoxic. Oral use of turmeric and curcumin did not have reproductive toxicity in animals at certain doses. Studies on human did not show toxic effects, and curcumin was safe at the dose of 6 g/day orally for 4-7 weeks. However, some adverse effects such as gastrointestinal upsets may occur. Moreover, oral bioavailable formulations of curcumin were safe for human at the dose of 500 mg two times in a day for 30 days, but there are still few trials and more studies are needed specially on nanoformulations and it should be discussed in a separate article. In addition, curcumin is known as a generally recognized as safe substance. This review discusses the safety and toxicity of turmeric and curcumin in medicine. Turmeric and curcumin are nontoxic for human especially in oral administration. Turmeric and curcumin are also safe in animals. They are nonmutagenic and are safe in pregnancy in animals but more studies in human are needed. Copyright © 2018 John Wiley & Sons, Ltd.

Analysis of the potencial of natural illumination for the savings and efficient use of the energy in buildings located in hot climates; Analisis del potencial de la iluminacion natural para ahorro y uso eficiente de la energia en las edificaciones en climas calidos

Energy Technology Data Exchange (ETDEWEB)

Garcia Chavez, J. R. [Universidad Autonoma Metropolitana-Azcapotzalco, Division de Ciencias y Artes para el Diseno, Departamento de Medio Ambiente, (Mexico)

1997-12-31

Daylight is an essential factor in lightening buildings. Its use is not only oriented to supply illumination to the spaces to provide adequate lightening levels for the optimum execution of their occupants` tasks, but also to supply the appropriate illumination level required in each case for specific functions, as well as to contribute to the psychophysiological health of its users and provide a favorable ambient and the germicide action in the ultraviolet component of the sunlight and besides a portion of vitamin {sup D,} that is needed for people`s health. On the other hand, the rational and efficient use of daylight can contribute to the diminish the consumption of electric power, that is used for the artificial lightning of buildings. This situation is particularly important in hot climates, where the consumption of electricity for lightening interior spaces is huge, mainly in non-dwelling buildings. In this paper the possibilities of the utilization of daylight are explored and analyzed for the purpose of achieving energy savings and the visual thermal and lightning comfort in buildings. [Espanol] La luz natural diurna es un factor indispensable en los edificios. Su uso no solamente esta orientado a proveer de iluminacion a los espacios para proporcionar niveles de iluminancia adecuados para la optima realizacion de las tareas visuales de los ocupantes, sino tambien para proporcionar la calidad luminica que se requiere para cada caso y funcion especificas, asi como contribuir a la salud psicofisiologica de los usuarios al brindarles un ambiente favorable y la accion germicida en la componente ultravioleta luminica y ademas, un contenido de vitamina {sup D,} necesario para la salud de las personas. Por otra parte, el uso sensato y eficiente de la luz natural diurna puede contribuir a reducir el consumo de energia electrica que se utiliza para el alumbrado artificial de los edificios. Esta situacion es de particular importancia en climas calidos, donde los

Analysis of the potencial of natural illumination for the savings and efficient use of the energy in buildings located in hot climates; Analisis del potencial de la iluminacion natural para ahorro y uso eficiente de la energia en las edificaciones en climas calidos

Energy Technology Data Exchange (ETDEWEB)

Garcia Chavez, J R [Universidad Autonoma Metropolitana-Azcapotzalco, Division de Ciencias y Artes para el Diseno, Departamento de Medio Ambiente, (Mexico)

1998-12-31

Daylight is an essential factor in lightening buildings. Its use is not only oriented to supply illumination to the spaces to provide adequate lightening levels for the optimum execution of their occupants` tasks, but also to supply the appropriate illumination level required in each case for specific functions, as well as to contribute to the psychophysiological health of its users and provide a favorable ambient and the germicide action in the ultraviolet component of the sunlight and besides a portion of vitamin {sup D,} that is needed for people`s health. On the other hand, the rational and efficient use of daylight can contribute to the diminish the consumption of electric power, that is used for the artificial lightning of buildings. This situation is particularly important in hot climates, where the consumption of electricity for lightening interior spaces is huge, mainly in non-dwelling buildings. In this paper the possibilities of the utilization of daylight are explored and analyzed for the purpose of achieving energy savings and the visual thermal and lightning comfort in buildings. [Espanol] La luz natural diurna es un factor indispensable en los edificios. Su uso no solamente esta orientado a proveer de iluminacion a los espacios para proporcionar niveles de iluminancia adecuados para la optima realizacion de las tareas visuales de los ocupantes, sino tambien para proporcionar la calidad luminica que se requiere para cada caso y funcion especificas, asi como contribuir a la salud psicofisiologica de los usuarios al brindarles un ambiente favorable y la accion germicida en la componente ultravioleta luminica y ademas, un contenido de vitamina {sup D,} necesario para la salud de las personas. Por otra parte, el uso sensato y eficiente de la luz natural diurna puede contribuir a reducir el consumo de energia electrica que se utiliza para el alumbrado artificial de los edificios. Esta situacion es de particular importancia en climas calidos, donde los

Curcuminoids from Curcuma longaL. reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive, proliferative, anti-inflammatory and antioxidant effects

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Edvande Xavier dos Santos Filho

Full Text Available Introduction: Intestinal mucositis is a frequent limiting factor in anticancer therapy and there is currently no broadly effective treatment targeted to cure this side effect. Objective: This study aimed to evaluate the effects of a mucoadhesive formulation containing curcuminoids (MFC from Curcuma longa L. on the pathogenesis of 5-fluorouracil (5-FU-induced intestinal mucositis. Methods: Three intraperitoneal 5-FU injections (200 mg/kg were used to induce intestinal mucositis in adult Swiss male mice. Treatment was provided orally (MFC 3.75, 7.5 and 15 mg/kg, thirty minutes before 5-FU injections, daily until euthanasia. Duodenal samples were collected to perform morphometric and histopathological analysis, to investigate the expression of Ki-67, p53, Bax and Bcl-2 by immunohistochemistry, to evaluate neutrophil activity myeloperoxidase (MPO-mediated and oxidative stress by malondialdehyde (MDA determination. Mice body weight was assessed as well. Results: As expected, 5-FU induced a significant weight loss (∼17%, P < 0.001, shortening in villi height (∼55.4% and crypts depth (∼47%, and increased (∼64% the histological severity score when compared to other groups (P < 0.05. These pathological changes were markedly alleviated by the three MFC treatment doses (P < 0.05, in special with the dose MFC 15 mg/kg. This dose also stimulated cell proliferation by ∼90% in the epithelial cells lining from villi and crypts (P < 0.05, reduced MPO levels and MDA formation by 60% and 44%, respectively (P < 0.05. Conclusions: Our data suggest the therapeutic potential of the formulation for treating intestinal mucositis in mice. Supplementary studies are underway searching for the elucidation of mechanisms involved in the protective effects of MFC in order to make this formulation a clinical tool for mucositis treatment. Keywords: Mucoadhesive formulation, Curcuminoids, Curcuma longa L, Intestinal mucositis, 5-Fluorouracil

Avaliação da intensidade de luz e da manutenção dos aparelhos fotopolimerizadores utilizados em clínicas odontológicas da cidade do Recife-PE

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Rafael Antonio de Oliveira RIBEIRO

Full Text Available Resumo Objetivo Avaliar os aparelhos fotopolimerizadores utilizados em clínicas da cidade do Recife e a manutenção realizada nesses aparelhos. Método Os profissionais participaram da avaliação de forma voluntária e não foram identificados nos questionários que foram por eles respondidos. Foi perguntado sobre os métodos de desinfecção, a frequência de troca de lâmpadas e a frequência da técnica empregada de manutenção. Também foi realizada a avaliação do aparelho fotopolimerizador, registrando as informações referentes a modelo, marca e data de aquisição. Foi realizada a mensuração da intensidade de luz utilizando-se um radiômetro (Demetron®. Resultado Todos os aparelhos fotopolimerizadores estavam com intensidade de luz inferior a 300 mW/cm2; 96,7% dos profissionais realizavam manutenção técnica de seus aparelhos apenas quando necessário; 100% trocavam a lâmpada só quando a mesma queimava; 40% dos aparelhos fotopolimerizadores encontravam-se acoplados ao equipo; 86,6% dos aparelhos apresentavam detritos na fibra óptica; 50% dos filtros apresentavam fraturas, sendo que 86,66% dos mesmos apresentavam detritos; 60% dos profissionais empregavam apenas álcool 70° como método de desinfecção; 53% dos entrevistados realizavam o método de desinfecção após cada paciente. Conclusão Todos os aparelhos fotopolimerizadores avaliados estavam com intensidade de luz abaixo do preconizado e constatou-se a inexistência de um protocolo de manutenção preventiva periódica.

Control del crecimiento y desarrollo de las plantas por la luz: Funciones fotoperceptivas y mecanismos de acción del fitocromo A

OpenAIRE

Yanovsky, Marcelo Javier

1999-01-01

La luz es un factor ambiental crítico para el crecimiento y desarrollo de las plantas. Provee no solo la energía lumínica necesaria para el proceso fotosíntético, sino también señales informativas que las plantas utilizan para coordinar su crecimiento y desarrollo con el ambiente circundante. La percepción de las señales lumínicas esta mediada por fotorreceptores específicos como los fitocromos. Estos son una pequeña familia de proteínas codificada por cinco genes en Arabidopsis thaliana, FIT...

Hypoglycemic, hypolipidemic and antioxidant properties of combination ofCurcumin fromCurcuma longa, Linn, and partially purified product fromAbroma augusta, Linn. in streptozotocin induced diabetes.

Science.gov (United States)

Ali Hussain, Halim Eshrat M

2002-07-01

Dietary spice components ofCurcuma longa andAbroma augusta have been screened for their protective effect against reactive oxygen species induced lipid peroxidation. They have been found to be efficient antioxidant when administered in combination. The purpose of the study was to investigate the effect of oral administration (300mg/Kg) of the aqueous extract of turmeric whose active ingredient isCurcumin andAbromine powder as a hypoglycemic agent mixed with diet. The effect of this aqueous extract on blood glucose, lipid peroxidation (LPO) and the antioxidant defense system in rat tissues like liver, lung, kidney and brain was studied for 8 weeks in streptozotocin induced diabetic rats. The administration of an aqueous extract of turmeric and abromine powder resulted in a significant reduction in blood glucose and an increase in total haemoglobin. The aqueous extract also resulted in decreased free radical formation in the tissues studied.The decrease in thiobarbituric acid reactive substances (TBARS) and increase in reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) clearly showed the antioxidant property of the mixture. It is suggested that these changes initially counteract the oxidative stress in diabetes however, a gradual decrease in the antioxidative process may be one of the factors which results in chronic diabetes. These results indicate that the mixture of the two plants have shown antidiabetic activity and also reduced oxidative stress in diabetes. A combination ofAbroma augusta and Curcuma longa also restored the other general parameters in diabetic animals. The results were statistically analyzed and indicated that combination of herbal extracts showed better efficacy as compared to individual herbal plant extracts used.

Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition.

Science.gov (United States)

Wright, Laura E; Frye, Jennifer B; Timmermann, Barbara N; Funk, Janet L

2010-09-08

Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague-Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60 mg/kg 3x per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy X-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by microcomputerized tomography (microCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor.

O modelo ondulatório como estratégia de promoção da evolução conceitual em tópicos sobre a luz em nível Médio

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Jales de Aquino Silva

2014-03-01

Full Text Available Este estudo trata da verificação da viabilidade de se promoverem estratégias de ensino de tópicos sobre a luz a partir da sua natureza ondulatória, buscando evidências de aprendizagem em um curso de nível Médio. Um grupo de alunos foi submetido a situações instrucionais, elaboradas na perspectiva da Teoria dos Campos Conceituais de Vergnaud e da Teoria da Aprendizagem Significativa de Ausubel, com o objetivo de criar condições favoráveis à evolução conceitual e, com isso, promover uma maior compreensão, por parte dos alunos, dos fenômenos relacionados ao tema. Apesar das condições de infraestrutura precárias para a realização deste estudo, os resultados nos revelaram evidências de evolução conceitual e a viabilidade de se tratarem tópicos sobre a luz a partir da teoria ondulatória.

Determinação do teor de sílica em madeira por espectroscopia de absorção atômica de chama versus espectroscopia no ultravioleta-visível.

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Laécio Carneiro Rodrigues

2009-10-01

Full Text Available Normal 0 21 MicrosoftInternetExplorer4 O presente trabalho teve como objetivo comparar o desempenho de duas técnicas analíticas, espectroscopia de absorção atômica de chama (FAAS e espectroscopia no ultravioleta-visível (UV-VIS, na determinação do teor de sílica em materiais lignocelulósicos. Os métodos foram testados em amostras de madeira de três árvores de Apuleia leiocarpa (Vog. Macbride. Os resultados mostraram que ambas as técnicas apresentam bons resultados, no entanto, a FAAS apresenta melhor precisão, rapidez e simplicidade operacional. Entretanto, a aplicação da espectroscopia UV-VIS é justificada pelo fato de os custos de aquisição e manutenção de um espectrofotômetro UV-VIS serem muito inferiores àqueles de um espectrômetro de absorção atômica. O uso da técnica FAAS deve ser preferido apenas quando os teores de sílica a serem determinados forem muito baixos, tendo em vista que a espectroscopia UV-VIS, nesses casos, não apresenta boa precisão.

Polyphenolic Composition and Antioxidant Activities of 6 New Turmeric (Curcuma Longa L.) Accessions.

Science.gov (United States)

Chinedum, Eleazu; Kate, Eleazu; Sonia, Chukwuma; Ironkwe, Adanma; Andrew, Igwe

2015-01-01

The phytochemical composition and antioxidant capacities of 6 new NRCRI turmeric (Curcuma longa L.) accessions (39, 35, 60, 30, 50 and 41) were determined using standard techniques. The moisture contents of the tumeric samples ranged from 15.75 to 47.80% and the curcumin contents of the turmeric samples fell within the range of curcumin obtained from turmeric in other countries of the world. Furthermore, the turmeric accessions contained considerable amounts of antioxidants (measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and reducing power assays), alkaloids, flavonoids, anthocyanins, and phenolics. There was significant correlation between the anthocyanin contents of the tumeric accessions versus their alkaloid (0.744) and flavonoid contents (0.986) suggesting an additive effect between the anthocyanins and alkaloids in turmeric; significant correlation between the inhibition of the turmeric accessions on DPPH radical versus their flavonoid (0.892) and anthocyanin (0.949) contents and significant correlation between the reducing power of the turmeric accessions versus their flavonoid (0.973) and anthocyanin (0.974) contents suggesting that anthocyanins as flavonoids largely contribute to the antioxidant activities of turmeric. The positive regression recorded between inhibition of DPPH radical by the turmeric accessions and quercetin versus reducing power (R2 = 0.852) suggest that any of these methods could be used to assess the antioxidant activities of tumeric. Finally, the study indicated the potentials of the turmeric accessions especially accessions 30 and 50 as promising sources of antioxidants.

Análisis de la estrategia de campaña del candidato Antanas Mockus (marzo 2010 - junio 2010) a la luz de las herramientas del marketing político moderno de Philippe Maarek.

OpenAIRE

Fernández Cárdenas, Alejandra Zoé

2012-01-01

En el siguiente documento se hace un análisis de la contienda electoral del 2010 en Colombia, haciendo un mayor énfasis en la campaña del candidato Antanas Mockus a la luz de las herramientas del marketing político moderno según Philippe Maarek.

Influência da maceração carbônica e da irradiação ultravioleta nos níveis de trans-resveratrol em vinhos de uva cabernet sauvignon Influence of the carbonic maceration on the levels of trans-resveratrol in cabernet sauvignon wine

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Silvana Maria Michelin Bertagnolli

2007-03-01

Full Text Available O consumo moderado de vinho reduz significativamente os riscos de doenças cardiovasculares. Este efeito é atribuído aos polifenóis presentes no vinho, em especial ao resveratrol (3,5,4'-triidroxiestilbeno, que é uma fitoalexina encontrada em várias partes da videira, principalmente na casca da uva, assim como em outras espécies de plantas. Uvas da cultivar Cabernet Sauvignon foram submetidas à irradiação com luz ultravioleta e maceração carbônica e após fermentadas. Procedeu-se à coleta de amostras durante todo o experimento, as quais foram posteriormente analisadas quanto ao teor de trans-resveratrol através da Cromatografia Líquida de Alta Eficiência. Os resultados do trabalho demonstram que a evolução do conteúdo de trans-resveratrol foi ascendente durante as fases da fermentação. Diferenças ocorreram no final da fermentação, em que as amostras de vinhos com maceração carbônica apresentaram leve declínio, possivelmente pela atmosfera de CO2 na qual ficaram armazenadas, inibindo a formação do resveratrol. Ao final da fermentação principal a concentração de trans-resveratrol foi de 15 mg.L-1 em todos os tratamentos, chegando a 1,5 mg.L-1, em média, no final do período de estocagem.The moderate consumption of wine reduces the risks of heart diseases significantly. This effect is attributed to the polyphenols found in the wine, in special to resveratrol (3,5,4'-trihidroxistilbene that it is a phytoalexin found in the various parts of the vine, including in the skin of the grape, as well as in other species of plants. Grapes of cultivar Cabernet Sauvignon had been submitted to the irradiation with ultra-violet light and carbonic maceration and after fermented. It was proceeded all collection from samples during the experiment, which later had been analyzed how much to the concentration of trans-resveratrol using the Liquid Chromatography of High Efficiency. The of the content of trans-resveratrol was ascendent

Relação entre atividade de plasmina e frações de caseína durante o armazenamento do leite longa vida Relationship between plasmin activity and casein fractions during storage of UHT milk

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Carlos Humberto Corassin

2013-03-01

Full Text Available Este estudo teve como objetivo correlacionar a atividade da plasmina e as concentrações de frações de caseína no leite longa vida (UAT produzido em usina de beneficiamento do Estado de São Paulo. O leite cru foi submetido à pasteurização (72-76 ºC, 15-20 segundos, seguida da esterilização por processo de injeção direta de vapor (132-136 ºC, 34 segundos, sendo homogeneizado e envasado assepticamente em embalagens cartonadas. Quatro lotes de UAT foram analisados para atividade de plasmina e frações de caseína após 10, 30, 60, 90 e 120 dias de armazenamento. A atividade de plasmina no leite longa vida aumentou durante o armazenamento, correlacionando-se negativamente com a concentração de αs1-caseína. A atividade da plasmina apresenta resistência à esterilização do leite pelo processo UAT e aumenta a proteólise do leite longa vida como consequência da degradação da αs1-caseína.The objective of this study was to correlate the plasmin activity and the concentrations of casein fractions in ultra-high-temperature (UHT milk manufactured in a dairy plant in the State of Sao Paulo, Brazil. Raw milk was pasteurized (72-76 ºC, 15-20 seconds, followed by direct steam injection into the milk (132-136 ºC, 34 seconds, then homogenized and aseptically packaged into cartons. Four replicates of the UHT milk were analyzed for the plasmin activity and casein fractions after 10, 30, 60, 90 and 120 days of storage. Plasmin activity significantly increased in the UHT milk during storage and was negatively correlated with the concentration of αs1-casein. Plasmin is resistant to milk sterilization by the UHT process, and increases proteolysis of the UHT milk as a consequence of αs1-casein degradation.

'Luz para Todos' (Light for Everyone) program: the need for subsidized funding: ELEKTRO case study; Programa luz para todos todos: a necessidade do aporte de recursos subsidiados - estudo de caso ELEKTRO

Energy Technology Data Exchange (ETDEWEB)

Strazzi, Paulo Ernesto [Secretaria de Saneamento e Energia do Estado de Sao Paulo (CERESP), SP (Brazil); Betiol Junior, Genesio [Universidade Cidade de Sao Paulo (UNICID), Tatuape, SP (Brazil); Marques, Fernando [Universidade de Sao Paulo (PIPGE/IEE/USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-Graduacao em Energia; Ribeiro, Fernando Selles [Universidade de Sao Paulo (EP/USP), SP (Brazil). Escola Politecnica; Guerra, Fernando Sinclair Mallet Guy [Universidade Federal do ABC (UFABC), Santo Andre, SP (Brazil)], email: sguerra@ufabc.edu.br

2008-07-01

In this paper we have analysed the Luz Para Todos (Light For Everyone) program in the state of Sao Paulo. We studied the case of ELEKTRO and focused on cost reduction and the economical and financial feasibility of the program. We used the work and experience of the Comissao de Eletrificacao Rural do Estado de Sao Paulo - CERESP (Rural Electric Commission of the Sao Paulo estate) as the basis of this study, which has developed a tool based on the construction plans of companies and cooperatives. This tool aimed to reduce the project costs uses concepts of low cost materials and equipment as well as the concepts of project finance analysis. It considers the funding source, financial statements of the companies and the return of a project. The Light For Everyone project has a social objective to take electricity to rural regions. It fulfils the needs of low income population. The execution of this program requires the participation of a private player which is an electricity distribution company. The economical and financial feasibility of the project is favoured by governmental subsidies. This study shows the dimension of the return obtained by the private player (executing agent). (author)

Synergistic and antimicrobial properties of commercial turmeric (Curcuma longa essential oil against pathogenic bacteria Propriedades antimicrobianas e sinergísticas de óleo essencial comercial de cúrcuma (Curcuma longa contra bactérias patogênicas

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Sara Albino Antunes

2012-09-01

Full Text Available Several studies have shown the antimicrobial and antioxidant properties of turmeric (Curcuma longa, widely used in food industry as a colorant, among other functions. The aim of this study was to determine the antioxidant and antimicrobial properties of turmeric essential oil against pathogenic bacteria and to study the influence of the addition of ascorbic acid on the prevention of polyphenols oxidation. The commercial turmeric essential oil alone did not show bactericidal activity against the microorganisms studied, Listeria monocytogenes and Salmonella typhimurium, but when combined with ascorbic acid, it showed significant antibacterial activity. The highest antimicrobial activity of turmeric essential oil against Salmonella typhimurium was 15.0 ± 1.41 mm at the concentration of 2.30 mg.mL-1 of essential oil and 2.0 mg.mL-1 of ascorbic acid. With regard to Listeria monocytogenes, the largest zone of inhibition (13.7 ± 0.58 mm was obtained at the same concentrations. The essential oil showed antioxidant activity of EC50 = 2094.172 µg.mL-1 for the DPPH radical scavenging method and 29% under the concentration of 1.667 mg.mL-1 for the β-carotene bleaching method.Vários estudos têm demonstrado as propriedades antimicrobianas e antioxidantes da cúrcuma (Curcuma longa, a qual é amplamente utilizada na indústria de alimentos, entre outras funções, para colorir. O objetivo deste estudo foi determinar as atividades antioxidantes e antimicrobianas do óleo essencial comercial de cúrcuma contra bactérias patogênicas, além de estudar a influência do ácido ascórbico na prevenção da oxidação dos polifenóis. O óleo essencial comercial de cúrcuma não apresentou atividade bactericida contra os micro-organismos estudados, Listeria monocytogenes e Salmonella typhimurium, mas, analisado com o ácido ascórbico, apresentou atividade antibacteriana considerável. A maior atividade antimicrobiana do óleo contra Salmonella typhimurium foi

In vitro larvicidal effects of ethanolic extract of Curcuma longa Linn. on Haemonchus larval stage

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Norisal Binti Nasai

2016-04-01

Full Text Available Aim: Gastrointestinal helminthosis is a global problem in small ruminant production. Most parasites have developed resistance to commonly available anthelminthic compounds, and there is currently an increasing need for new compounds with more efficacies. This study evaluated the in vitro effects of ethanolic extract of Curcuma longa (EECL as a biological nematicide against third stage Haemonchus larvae (L3 isolated from sheep. Materials and Methods: Haemonchus L3 were cultured and harvested from the feces of naturally infected sheep. EECL was prepared and three concentrations; 50, 100, and 200 mg/mL were tested for their efficacies on Haemonchus L3. Levamisole at concentration 1.5 and 3 mg/mL were used as positive controls. Results: EECL showed anthelmintic activity in a dose-dependent manner with 78% worm mortality within 24 h of exposure at the highest dose rate of 200 mg/mL. There was a 100% worm mortality rate after 2 h of levamisole (3 mg/mL admisntration. However, there was a comparable larvicidal effect between when levamisole (1.5 mg/mL and EECL (200 mg were administered. Conclusion: The study shows that EECL does exhibit good anthelmintic properties at 200 mg/mL which is comparable with levamisole at 1.5 mg/mL.

Effect of balanced low pressure drying of curcuma longa leaf on skin immune activation activities.

Science.gov (United States)

Choi, Wooseok; Lim, Hye Won; Lee, Hyeon Yong

2014-01-01

The effect of balanced low pressure drying pretreatment associated with ultrasonication extraction (BU) on the enhancement of skin immune modulatory activities of Curcuma longa leaf was studied by comparing with conventional hot air drying (HE), freeze drying (FE) and balanced low pressure drying (BE) pretreatment processes. In considering skin immune activation activities such as the inhibition of hyaluronidase activity, the BU extract showed ca. 10% higher than those of HE, and even higher than that of the FE extract. Nitric oxide production from macrophage of the BU extract in adding 1.0 mg/mL was increased up to 16.5 μM. When measuring inhibition of IL-6 and TNF-a production from the human T lymphocytes (T cell), the BU extract also showed 53% and 78% of inhibition effect, respectively. It is found that the BU extract could effectively suppress the expression levels of skin inflammation related genes such as Cox-2 and iNOS, down to 80% and 85% compared to the control, respectively. Balanced low pressure drying process was especially active on dehydration of the leaves with minimizing the destruction and making easier elution of the bioactive substances, which resulted in higher extraction yield and better biological activities.

Effect of acidity on the energy level of curcumin dye extracted from Curcuma longa L

International Nuclear Information System (INIS)

Agustia, Yuda Virgantara; Suyitno,; Sutanto, Bayu; Arifin, Zainal

2016-01-01

The purpose of this research is to investigate the effect of acidity on the energy level of curcumin dye. The natural dye, curcumin, was synthesized from Curcuma longa L. using a simple extraction technique. The purification of curcumin dye was conducted in a column of chromatography and its characteristics were studied. Next, the purified curcumin dye was added by benzoic acids until various acidities of 3.0, 3.5, 4.0, 4.5, and 5.0. The absorbance spectra and the functionality groups found in the dyes were detected by ultraviolet-visible spectroscopy and Fourier-transform infrared spectroscopy, respectively. Meanwhile, the energy level of the dyes, E_H_O_M_O and E_L_U_M_O was measured by cyclic voltammetry. The best energy level of curcumin dye was achieved at pH 3.5 where E_r_e_d = −0.37V, E_L_U_M_O = −4.28 eV, E_o_x = 1.15V, E_H_O_M_O = −5.83 eV, and E_b_a_n_d _g_a_p = 1.55 eV. Therefore, the purified curcumin dye added by benzoic acid was promising for sensitizing the dye-sensitized solar cells.

Efficacy of combination herbal product (Curcuma longa and Eugenia jambolana) used for diabetes mellitus.

Science.gov (United States)

Rao, Sadia Saleem; Najam, Rahila

2016-01-01

The purpose of this research was to evaluate the efficacy of a combination herbal product that is traditionally used for managing diabetes mellitus. Herbal drug contains Curcuma longa and Eugenia jambolanain the ratio of 1:1. It was orally administered at the dose of 1082 mg/70 kg twice a day for a period of 6 weeks to alloxan induced diabetic rats and compared with glibenclamide (standard). The effects of drug were observed at intervals, with respect to random and fasting glucose levels. HbA1C was also monitored after the drug treatment to monitor the overall diabetic effect. Results revealed that the combination of two herbs significantly reduced fasting and random glucose levels with HbA1C of less than 6% (p<0.001) in comparison to diabetic control. The control of fasting blood glucose levels by herbal combination is similar to the standard drug, glibenclamide (p<0.05). Random glucose levels by herbal combination is better than standard drug after one week and six weeks of treatment (p<0.01 and p<0.001 respectively) and similar after third week of treatment (p<0.05). Also, herbal drug combination showed HbA1C closer to the standard drug. It shows that this herbal combination can be of potential benefit in managing diabetes mellitus in future.

Improvement in antioxidant functionality and shelf life of yukwa (fried rice snack) by turmeric (Curcuma longa L.) powder addition.

Science.gov (United States)

Lim, Seung-Taik; Han, Jung-Ah

2016-05-15

The physico-chemical, oxidative and sensory characteristics of fried rice snack, yukwa with different amounts of turmeric powder (Curcuma longa) were investigated. The moisture content of the pallet ranged from 16.47% to 19.84%. After frying the pallet, a slight decrease in the degree of expansion was obtained with increasing turmeric powder content. The textural properties of yukwa were not changed until the turmeric powder content reached 5%; however, over 8% addition induced a decrease in the hardness and an increase in the crispiness. Oxidative deterioration was effectively inhibited by turmeric powder addition, and more turmeric powder in yukwa led to higher free radical scavenging activity. Based on the sensory characteristics, a 5% addition of turmeric powder was the most acceptable for the yukwa product. In the correlation results among variables, the moisture content of the pallet proved to be the most important factor for yukwa quality. Copyright © 2015 Elsevier Ltd. All rights reserved.

Mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus.

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Hu, Yichen; Zhang, Jinming; Kong, Weijun; Zhao, Gang; Yang, Meihua

2017-04-01

The antifungal activity and potential mechanisms in vitro as well as anti-aflatoxigenic efficiency in vivo of natural essential oil (EO) derived from turmeric (Curcuma longa L.) against Aspergillus flavus was intensively investigated. Based on the previous chemical characterization of turmeric EO by gas chromatography-mass spectrometry, the substantially antifungal activities of turmeric EO on the mycelial growth, spore germination and aflatoxin production were observed in a dose-dependent manner. Furthermore, these antifungal effects were related to the disruption of fungal cell endomembrane system including the plasma membrane and mitochondria, specifically i.e. the inhibition of ergosterol synthesis, mitochondrial ATPase, malate dehydrogenase, and succinate dehydrogenase activities. Moreover, the down-regulation profiles of turmeric EO on the relative expression of mycotoxin genes in aflatoxin biosynthetic pathway revealed its anti-aflatoxigenic mechanism. Finally, the suppression effect of fungal contamination in maize indicated that turmeric EO has potential as an eco-friendly antifungal agent. Copyright © 2016 Elsevier Ltd. All rights reserved.

Stability of Curcuma longa rhizome lectin: Role of N-linked glycosylation.

Science.gov (United States)

Biswas, Himadri; Chattopadhyaya, Rajagopal

2016-04-01

Curcuma longa rhizome lectin, a mannose-binding protein of non-seed portions of turmeric, is known to have antifungal, antibacterial and α-glucosidase inhibitory activities. We studied the role of complex-type glycans attached to asparagine (Asn) 66 and Asn 110 to elucidate the role of carbohydrates in lectin activity and stability. Apart from the native lectin, the characteristics of a deglycosylated Escherichia coli expressed lectin, high-mannose oligosaccharides at both asparagines and its glycosylation mutants N66Q and N110Q expressed in Pichia pastoris, were compared to understand the relationship between glycosylation and activity. Far UV circular dichroism (CD) spectra, fluorescence emission maximum, hemagglutination assay show no change in secondary or tertiary structures or sugar-binding properties between wild-type and aforementioned recombinant lectins under physiological pH. But reduced agglutination activity and loss of tertiary structure are observed in the acidic pH range for the deglycosylated and the N110Q protein. In thermal and guanidine hydrochloride (GdnCl)-induced unfolding, the wild-type and high-mannose lectins possess higher stability compared with the deglycosylated recombinant lectin and both mutants, as measured by a higher Tm of denaturation or a greater free energy change, respectively. Reversibility experiments after thermal denaturation reveal that deglycosylated proteins tend to aggregate during thermal inactivation but the wild type shows a much greater recovery to the native state upon refolding. These results suggest that N-glycosylation in turmeric lectin is important for the maintenance of its proper folding upon changes in pH, and that the oligosaccharides help in maintaining the active conformation and prevent aggregation in unfolded or partially folded molecules. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Innovación y ruptura en la métrica de la poesía en al-Maqāmāt al-Luzūmiyya de al-Saraqusṭī (s. VI/XII

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Ferrando, Ignacio

2016-06-01

Full Text Available Al-Maqāmāt al-Luzūmiyya, a collection of 50 picaresque-like stories couched in rhymed prose by Abū l-Ṭāhir al-Saraqusṭī in al-Andalus in the VI/XIIth century, were considered by Western scholars, up until the eighties of XXth century, as highly rhetorical pieces with a negligible and irrelevant content. However, some contemporary scholars argued that they contain some degree of social and political criticism, as they constitute a fictional domain in which subversion and irony play a fundamental role. In this paper, we cast some light on the particular use of metrical patterns in Al-Maqāmāt al-Luzūmiyya, which should be considered another subversion field: a poetical rhythm that avoids the most usual Arabic metrical patterns, contributing to provide the maqāma a flavor of the countergenre.Al-Maqāmāt al-Luzūmiyya, la colección de 50 relatos de corte picaresco escritos en una exigente prosa rimada por Abū l-Ṭāhir al-Saraqusṭī en al-Andalus en el siglo VI/XII, han sido consideradas por los críticos occidentales como piezas de alta retórica y de virtuosismo lingüístico en las que el contenido es prácticamente irrelevante. Sin embargo, a partir de los años 80 del siglo pasado, algunos investigadores han tratado de incidir en el hecho de que esta obra contiene cierto grado de crítica social y política, puesto que constituye un espacio ficticio en el que la subversión y la ironía desempeñan un papel fundamental. En este trabajo vamos a tratar de arrojar luz sobre el uso particular de los esquemas métricos por parte de al-Saraqusṭī, tratando de mostrar que los metros constituyen otro más de los ámbitos de subversión tan caros al autor. De hecho, el uso de ritmos “invertidos” o contrarios a los más habituales de la poesía clásica contribuye a darle a la maqāma ese aire de anti género que la puebla.

Luz, substrato e temperatura na germinação de sementes de cedro-vermelho Light, substrate and temperature in the germination of seeds of Cedrela odorata

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Marco Antônio Amaral Passos

2008-02-01

Full Text Available O objetivo deste estudo foi avaliar o tipo de substrato, a temperatura e os regimes de luz mais adequados à germinação de sementes de Cedrela odorata L. O delineamento experimental adotado, em todos os ensaios, foi o inteiramente casualizado com quatro repetições de 25 sementes cada. As temperaturas constantes de 25 e 30ºC, a temperatura alternada de 20-30ºC e os substratos pó de coco e areia são as melhores condições para a germinação das sementes de C. odorata. A germinação das sementes da espécie estudada não se mostrou sensível aos diferentes regimes de luz aplicados.This work aimed to evaluate the kind of substrate, and temperature and light conditions more suitable for seed germination of Cedrela odorata L. The experimental design adopted in all experiments was the completely randomized design with four repetitions of twenty-five seeds each. The constant temperatures (25 and 30ºC, the alternated temperature (20-30ºC, and the coconut fiber and sand substrates are the better conditions for seed germination of C. odorata. Seed germination of the studied specie showed no sensitiveness to the different levels of light applied.

Influence of gamma radiation on the colour strength and fastness properties of fabric using turmeric (Curcuma longa L.) as natural dye

International Nuclear Information System (INIS)

Bhatti, Ijaz A.; Adeel, Shahid; Jamal, M. Asghar; Safdar, Muhammad; Abbas, Muhammad

2010-01-01

The effect of gamma radiation on the dyeing of cotton with extract of turmeric (Curcuma longa L.) powder has been investigated. Cotton fabric and turmeric powder were irradiated to absorbed doses of 1, 2, 3, 4 and 6 kGy using Co-60 gamma irradiator. Dyeing parameters such as temperature, pH and mordant concentration were optimized. Dyeing was performed using un-irradiated and irradiated cotton with the extracts of un-irradiated and irradiated turmeric powder in order to investigate the effect of radiation treatment on the colour strength of dyed fabric. The reported data of un-irradiated and irradiated fabrics dyed with un-irradiated and irradiated dyes were obtained using the spectraflash SF-650. The colourfastness to light, rubbing- and washing-fastness properties showed that gamma irradiation has improved the dyeing characteristics from fair to good.

Influence of gamma radiation on the colour strength and fastness properties of fabric using turmeric (Curcuma longa L .) as natural dye

Science.gov (United States)

Bhatti, Ijaz A.; Adeel, Shahid; Jamal, M. Asghar; Safdar, Muhammad; Abbas, Muhammad

2010-05-01

The effect of gamma radiation on the dyeing of cotton with extract of turmeric ( Curcuma longa L.) powder has been investigated. Cotton fabric and turmeric powder were irradiated to absorbed doses of 1, 2, 3, 4 and 6 kGy using Co-60 gamma irradiator. Dyeing parameters such as temperature, pH and mordant concentration were optimized. Dyeing was performed using un-irradiated and irradiated cotton with the extracts of un-irradiated and irradiated turmeric powder in order to investigate the effect of radiation treatment on the colour strength of dyed fabric. The reported data of un-irradiated and irradiated fabrics dyed with un-irradiated and irradiated dyes were obtained using the spectraflash SF-650. The colourfastness to light, rubbing- and washing-fastness properties showed that gamma irradiation has improved the dyeing characteristics from fair to good.

Influence of gamma radiation on the colour strength and fastness properties of fabric using turmeric (Curcuma longa L.) as natural dye

Energy Technology Data Exchange (ETDEWEB)

Bhatti, Ijaz A., E-mail: ijazchem@yahoo.co [Department of Chemistry, University of Agriculture, Faisalabad 38040 (Pakistan); Adeel, Shahid [Department of Chemistry, University of Agriculture, Faisalabad 38040 (Pakistan); Jamal, M. Asghar [Department of Chemistry, G.C. University, Faisalabad 38040 (Pakistan); Safdar, Muhammad [Department of Chemistry, University of A J and K, Muzaffarabad, Azad Kashmir (Pakistan); Abbas, Muhammad [Haris Dyes and Chemicals, Faisalabad 38040 (Pakistan)

2010-05-15

The effect of gamma radiation on the dyeing of cotton with extract of turmeric (Curcuma longa L.) powder has been investigated. Cotton fabric and turmeric powder were irradiated to absorbed doses of 1, 2, 3, 4 and 6 kGy using Co-60 gamma irradiator. Dyeing parameters such as temperature, pH and mordant concentration were optimized. Dyeing was performed using un-irradiated and irradiated cotton with the extracts of un-irradiated and irradiated turmeric powder in order to investigate the effect of radiation treatment on the colour strength of dyed fabric. The reported data of un-irradiated and irradiated fabrics dyed with un-irradiated and irradiated dyes were obtained using the spectraflash SF-650. The colourfastness to light, rubbing- and washing-fastness properties showed that gamma irradiation has improved the dyeing characteristics from fair to good.

A SÍNDROME DA ALIENAÇÃO PARENTAL DIANTE DO DIVÓRCIO DOS PAIS: UMA PERSPECTIVA À LUZ DA LEI 12.318/10

OpenAIRE

Fernandes, Nathália Nayara Soares; URCA

2013-01-01

A temática do presente artigo tem por escopo mostrar um fenômeno que não é novo, mas que é desconhecido de muitas pessoas e que de certa forma, vem sendo tratado de forma retraída pelo universo jurídico. Trata-se da Síndrome da Alienação Parental (SAP), expressão esta, usada primeiramente por Richard Gardner, para caracterizar a influência que um dos genitores exerce sobre o filho para afastar o outro genitor. À luz de tal anseio, o presente trabalho tem por finalidade apresentar a Síndrome d...

Comportamento germinativo de sementes de leiteiro (Peschiera fuchsiaefolia: efeito da temperatura e luz Seed germination of Peschiera fuchsiaefolia: effects of temperature and light

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Cibele C. Martins

2000-01-01

Full Text Available O leiteiro é uma planta daninha que ocorre em pastagens, de importância crescente no Brasil e que reproduz-se por sementes. Com o objetivo de conhecer o comportamento germinativo dessa espécie, as sementes foram colocadas para germinar sobre papel, em temperaturas constantes de 15, 20, 25, 30, 35 e 40ºC, sem ou com luz (78 µmol s-1m-2/8h. Para a avaliação dos tratamentos, foram contabilizadas, semanalmente, o número de sementes germinadas (G, considerando-se a protrusão de 1cm de raiz primária, até que cessasse a germinação em todos os tratamentos (63 dias após a semeadura e, determinou-se o índice de velocidade de germinação (IVG. Após esse período, as sementesforam transferidas para a temperatura de 30ºC com luz (condição favorável detectada na etapa anterior e realizou-se contagem semanal até que a germinação cessasse novamente, em todos os tratamentos (91 dias após a semeadura, quando foram contabilizadas as sementes mortas (M e as sementes quiescentes (Q. Os resultados indicaram que as sementes de leiteiro foram indiferentes à luz. A temperatura ótima de germinação para a espécie situou-se entre 25 e 30ºC (G=85%, M=15% e IVG=34. Nas temperaturas extremas de 15ºC (G=0%; Q=78%; M=22% e 40 ºC (G=0%; Q=0% e M=100% não houve a germinação das sementes.Peschiera fuchsiaefolia is a pasture weed of great importance in Brazil. The objective of this research was to know the germination of this specie under constant temperatures of 15, 20, 25, 30 e 35ºC with and without light (78 µmol s-1m-2/8h. The germination was evaluated weekly up to 63 days after sowing. After this period all seeds were transferred to 30ºC without light because this condition was the best in previous period. In the new conditions the evaluation reached 91 days after sowing. In the end of the experimental period died seeds and quiescent seeds were evaluated. The best temperature to germination was between 25 and 30ºC with germination

Characteristics of HIV-infected childbearing women in Barbados Características de las mujeres con infección por VIH que dan a luz en Barbados

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Alok Kumar

2003-01-01

contributed significantly to both vertical and horizontal HIV transmission in Barbados. Future studies of HIV incidence and its trend among childbearing women could be important for monitoring the HIV epidemic in this country. Many of the HIV-infected childbearing women in our study were unemployed, sick, and had multiple children. Therefore, to help them to plan for and cope with the disease and also the care of their children beyond the perinatal period, there is a need to provide the women with repeated counseling with continued follow-up and, where necessary, additional economic, social, and medical support.OBJETIVO: Describir el perfil demográfico, las carácterísticas sociales y familiares y los hábitos de vida de las mujeres infectadas por VIH que dan a luz en Barbados, país del Caribe, en comparación con un grupo testigo compuesto de mujeres sin infección por VIH. MÉTODOS: Los datos en que se basa este informe fueron obtenidos del Programa Pediátrico para la Vigilancia del VIH en el Hospital Reina Isabel de Barbados. Los datos abarcaron a todas las mujeres en el país que estaban infectadas por el VIH y que dieron a luz entre 1986 y 2000. Datos similares se obtuvieron de un grupo testigo compuesto de mujeres que dieron a luz pero que no estaban infectadas por el VIH. De las fichas médicas de las mujeres se extrajo la información de tipo general que había sido anotada durante las consultas prenatales. Datos adicionales se recolectaron mediante entrevistas con las mujeres. RESULTADOS:Ciento ochenta y dos mujeres infectadas por el VIH dieron a luz durante el período de estudio, y un grupo de 202 mujeres que dieron a luz sin estar infectadas por el VIH sirvió de testigo. En comparación con las de este último, las mujeres infectadas por el VIH eran más jóvenes, multíparas más a menudo, y más propensas a haber estado sin empleo cuando estaban embarazadas. Las mujeres infectadas por el VIH también habían empezado a tener relaciones sexuales a m

REPENSANDO O DIREITO À SAÚDE E A RESPONSABILIDADE DO ESTADO À LUZ DA TEORIA DE JUSTIÇA DE JOHN RAWLS

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Heloisa Sami Daou

2017-06-01

Full Text Available Artigo que problematiza acerca da responsabilidade do Estado na garantia do direito à saúde à luz da teoria de justiça de John Rawls. Analisa-se, inicialmente, o direito à saúde, sua caracterização e tratamento constitucional. Depois, trata-se da política pública do SUS, bem como de alguns argumentos que negam a garantia do direito à saúde nos moldes concebidos pelo Constituinte. Por fim, com base na teoria de justiça como equidade de John Rawls, delineada na obra Uma teoria da Justiça, suscita-se reflexão envolvendo a responsabilidade do Estado na garantia do direito fundamental social à saúde.

Fine structure of the retinal pigment epithelium and cones of Antarctic fish Notohenia coriiceps Richardson in light and dark-conditions Ultraestrutra do epitélio pigmentar da retina e dos cones do peixe Antártico Notothenia coriiceps Richardson submetido à luz e ao escuro

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Lucélia Donatti

2007-03-01

Full Text Available The Antarctic fish Notothenia coriiceps Richardson, 1844 lives in an environment of daily and annual photic variation and retina cells have to adjust morphologically to environmental luminosity. After seven day dark or seven day light acclimation of two groups of fish, retinas were extracted and processed for light and transmission electron microscopy. In seven day dark adapted, retina pigment epithelium melanin granules were aggregated at the basal region of cells, and macrophages were seen adjacent to the apical microvilli, between the photoreceptors. In seven day light adapted epithelium, melanin granules were inside the apical microvilli of epithelial cells and macrophages were absent. The supranuclear region of cones adapted to seven day light had less electron dense cytoplasm, and an endoplasmic reticulum with broad tubules. The mitochondria in the internal segment of cones adapted to seven day light were larger, and less electron dense. The differences in the morphology of cones and pigment epithelial cells indicate that N. coriiceps has retinal structural adjustments presumably optimizing vision in different light conditions.O peixe Antártico Notothenia coriiceps Richardson, 1844 habita meios com variações fóticas diária e anual e as células da retina se adaptam morfologicamente a esta luminosidade ambiental. Dois grupos de peixes foram aclimatados durante sete dias à luz constante ou ao escuro constante. Após secção medular, as retinas foram extraídas e processadas para microscopia de luz e microscopia eletrônica de transmissão. No epitélio pigmentar da retina adaptado sete dias ao escuro, os pigmentos de melanina agregam-se na base coroidal das células epiteliais pigmentares e macrófagos são encontrados no interior do processos apicais entre as células fotorreceptoras. No epitélio adaptado sete dias à luz os pigmentos de melanina se dispõem ao longo das projeções apicais das células epiteliais pigmentares e os

A comparative evaluation of antibacterial effectiveness of sodium hypochlorite, Curcuma longa, and Camellia sinensis as irrigating solutions on isolated anaerobic bacteria from infected primary teeth

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Neha Shashikant Dhariwal

2016-01-01

Full Text Available Context: In endodontics, most of the commercial intra-canal medicaments have cytotoxic reactions and because of their inability to eliminate bacteria from dentinal tubules, recent medicine has turned its attention to the usage of biologic medication prepared from natural plants. The literature to testify the efficacy of natural alternatives in primary teeth is meagre and its effects as irrigating solutions need to be evaluated. Aim: To evaluate the antibacterial effectiveness of sodium hypochlorite, ethanolic extracts of Curcuma longa (turmeric and Camellia sinensis (green tea as irrigating solutions against the anaerobic bacteria isolated from the root canals of infected primary teeth. Materials and Methods: Thirty patients were selected based on the selected inclusion and exclusion criteria. Preoperative radiographs were taken. Rubber dam isolation and working length estimation were done, following which thirty samples were taken from the root canals of infected primary teeth using sterile absorbent paper points and transferred to tubes containing thioglycolate transport medium. The bacteria were then isolated using standard microbiological protocols and were subjected to antibiotic sensitivity testing using the three test irrigants. Statistical Analysis: SPSS 18 software using Chi-square test was used for statistical analysis. Results: The most commonly isolated bacteria included Porphyromonas sp., Bacteroides fragilis, Peptostreptococcus, and Staphylococcus aureus. Sodium hypochlorite and C. longa (turmeric showed good antibacterial effect and were effective against most of the isolated bacteria. There was statistically significant difference in the antibacterial effect among the three tested groups (P < 0.001. The least effective was C. sinensis (green tea. Conclusion: The infected primary teeth almost always present with a polymicrobial structure with a wide variety of anaerobic bacteria. The chemo-mechanical preparation plays an important

A comparative evaluation of antibacterial effectiveness of sodium hypochlorite, Curcuma longa, and Camellia sinensis as irrigating solutions on isolated anaerobic bacteria from infected primary teeth.

Science.gov (United States)

Dhariwal, Neha Shashikant; Hugar, Shivayogi M; Harakuni, Sheetal; Sogi, Suma; Assudani, Harsha G; Mistry, Laresh Naresh

2016-01-01

In endodontics, most of the commercial intra-canal medicaments have cytotoxic reactions and because of their inability to eliminate bacteria from dentinal tubules, recent medicine has turned its attention to the usage of biologic medication prepared from natural plants. The literature to testify the efficacy of natural alternatives in primary teeth is meagre and its effects as irrigating solutions need to be evaluated. To evaluate the antibacterial effectiveness of sodium hypochlorite, ethanolic extracts of Curcuma longa (turmeric) and Camellia sinensis (green tea) as irrigating solutions against the anaerobic bacteria isolated from the root canals of infected primary teeth. Thirty patients were selected based on the selected inclusion and exclusion criteria. Preoperative radiographs were taken. Rubber dam isolation and working length estimation were done, following which thirty samples were taken from the root canals of infected primary teeth using sterile absorbent paper points and transferred to tubes containing thioglycolate transport medium. The bacteria were then isolated using standard microbiological protocols and were subjected to antibiotic sensitivity testing using the three test irrigants. SPSS 18 software using Chi-square test was used for statistical analysis. The most commonly isolated bacteria included Porphyromonas sp., Bacteroides fragilis, Peptostreptococcus, and Staphylococcus aureus. Sodium hypochlorite and C. longa (turmeric) showed good antibacterial effect and were effective against most of the isolated bacteria. There was statistically significant difference in the antibacterial effect among the three tested groups (P < 0.001). The least effective was C. sinensis (green tea). The infected primary teeth almost always present with a polymicrobial structure with a wide variety of anaerobic bacteria. The chemo-mechanical preparation plays an important role in eradicating the population of predominant micro-organisms in treating these teeth with

VALIDACIÓN DE UNA METODOLOGÍA PARA LA DETERMINACIÓN DE CARBOFURAN EN SUELOS MEDIANTE CROMATOGRAFÍA LÍQUIDA DE ALTA EFICIENCIA CON DETECCIÓN ULTRAVIOLETA (CLAR-UV

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Yenny Valencia

2011-01-01

Full Text Available Se validó una metodología analítica que permite cuantificar residuos de carbofuran en muestras de suelo. La extracción del plaguicida desde la matriz se realizó mediante agitación mecánica empleando acetato de etilo como solvente, los extractos obtenidos se sometieron a extracción en fase sólida (EFS utilizando cartuchos C18, finalmente, la determinación y cuantificación del carbofuran se llevó a cabo mediante cromatografía líquida de alta eficiencia con detección ultravioleta (CLAR-UV a una longitud de onda de 205 nm. La metodología validada es específica y selectiva para el carbofuran, lineal en el rango desde 0,47 hasta 2,36 mgKg-1, precisa con un coeficiente de variación típico (CVtip de 10,78%; exacta brindando un porcentaje de recuperación para la metodología global (porcentaje de R equivalente a 98,25±3,97% y sensible con límites de detección y cuantificación de 0,045 y 0,149 mgKg-1, respectivamente. También se verificó la robustez del método. Se analizaron dos muestras de suelo dedicados al cultivo de café, y se encontraron residuos de carbofuran durante los primeros 30 días después de su aplicación.

High ultraviolet index (UVI in two cities of Antioquia (Colombia Altos índices de radiación ultravioleta en Medellín y en una localidad del oriente antioqueño (Colombia

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German Eduardo Hernández Garzón

2010-05-01

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Discussion and conclusions: This particular population appeared to be exposed to high levels of UV Radiation (UVR all year round. The use of the UVI may be a useful educative tool for the community in regards to the health risks of overexposure to UVR.

Introducción: la incidencia mundial de cáncer de piel se ha incrementado en las últimas dos décadas.

La exposición acumulada o crónica a la radiación ultravioleta es uno de los factores de riesgo más importantes para el desarrollo de melanoma, cáncer no-melanoma y cataratas. El índice ultravioleta (IUV ha sido diseñado para proveer información al público con el fin de inducir un comportamiento de protección hacia el sol.

Soft power, o brilho da espada:o Brasil e a ordem internacional pós 11 de setembro

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Roberto Goulart Menezes

2012-03-01

Full Text Available O objetivo deste artigo é examinar em que medida os eventos de 11 de setembro de 2001 contribuíram para a revisão da inserção internacional do Brasil e de como estes influíram na elaboração de uma nova estratégia no governo Lula da Silva (2003-2010. Entre as principais mudanças na agenda externa do País figuram a derrocada das negociações da ALCA, a busca de uma inserção soberana e o fortalecimento de uma ordem multipolar. Para isso, os eventos de 11 de setembro são discutidos à luz do conceito braudeliano de longa duração, que separa os acontecimentos de curta duração (os episódios daqueles que ressoam e acabam por mudar os rumos da história dos povos e das nações.

Negro é o inferno! Um ensaio sobre as cores dos homens, dos demônios e dos deuses

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Walker Douglas Pincerati

2016-10-01

Full Text Available http://dx.doi.org/10.5007/1984-8420.2016v17n2p46 Problematiza-se o par negro.branco na formação social brasileira, trabalhando a hipótese de que ‘negro’ não é cor, mas a metáfora do corpo do ser infernal. Estatísticas oficiais, a história da formação do Brasil, um enunciado de um Deputado Federal Pastor, o quadro A libertação dos Escravos de Pedro Américo (1889 e a história da construção das catedrais góticas medievais são evocadas para analisá-lo, desde o ponto de vista linguístico-discursivo. Nota-se, destarte, uma longa história do alinhamento dos significantes branco-luz-deuses-céu-liberdade... e negro-escuridão-demônios-inferno-escravidão... atuando ainda no nosso país.

EFFECT OF TURMERIC (CURCUMA LONGA ON OVERWEIGHT HYPERLIPIDEMIC SUBJECTS: DOUBLE BLIND STUDY

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Lekhani Pashine

2012-06-01

Full Text Available Objective: To evaluate the effect of turmeric (Curcuma longa on serum lipid profile in overweight hyperlipidemic subjects. Methods: This was a double blind randomised control study. The study was conducted in the Department of Medicine, CSM Medical University, Lucknow from July 2010-June 2011. A total of 120 subjects were interviewed using a pre-tested semi-structured schedule whose BMI>25 and total cholesterol>200 mg/dl and/or triglyceride>150 mg/dl, were divided randomly using random number table into 2 groups Group-I (Aquous extract of Turmeric-1.4 gm per day (n=53 and Group-II (Placebo (n=52 for three months. They were given the same color capsules without revealing their identity, with the instructions to take the contents of each pack twice a day before meal for 90 days. Subjects were asked to give their 12 hour fasting blood samples on 0, 30, 60 and 90 day. The paired t-test was used to compare the changes amongst follow-ups and unpaired t-test was used to compare between groups. p-value<0.05 was considered as significant. Results: At the baseline, both the groups were similar in anthropometric and clinical parameters. Treatment group produced significant (p<0.0001 reduction in lipid profiles such as serum total cholesterol, triglyceride and LDL-cholesterol and VLDL- cholesterol in hypercholesteremic group from 0 day to 30, 60 and 90 day of follow-ups. However, there was no significant change in the placebo group. The percentage reduction was higher in the subjects of Turmeric group as compared to Placebo. Conclusion: Aquous extract of Turmeric has shown lipid lowering properties among overweight hyperlipidemic subjects.

A reflexão da luz nos periódicos de Ensino de Física: evidenciando tendências e carências de pesquisa a partir de uma revisão bibliográfica

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Jair Lúcio Prados Ribeiro

2016-09-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2016v33n2p355   O artigo apresenta uma revisão bibliográfica acerca da reflexão luminosa. Foram revisados 152 artigos sobre o tema, publicados em revistas acadêmicas brasileiras e internacionais voltadas de forma específica para o ensino de física, entre 1995 e 2015. O diálogo entre os artigos foi estabelecido a partir de dez categorias de classificação dos textos, de acordo com o seu subtema específico: princípios da reflexão, refletância, velocidade da luz, reflexão difusa, imagens reais e virtuais, espelhos planos, espelhos curvos, associações de espelhos, polarização e espelhos relativísticos. A revisão evidenciou grande concentração de esforços de pesquisa em aplicações de espelhos curvos e planos. Por outro lado, temas como refletância, velocidade da luz, espelhos relativísticos e a relação entre os fenômenos da reflexão e da polarização mostraram carência de trabalhos. A revisão mostrou que esses quatro subtemas não são usuais nas publicações de autores brasileiros, demonstrando possibilidades de pesquisas futuras. O uso de materiais cotidianos em atividades experimentais também foi evidenciado, principalmente em artigos voltados para o tratamento da óptica no ensino médio, fato que contribui para a continuidade de pesquisas sobre o tema. Ressalta-se ainda que a celebração do Ano Internacional da Luz (2015 não parece ter alavancado de forma substancial as publicações sobre o tema.

Terceirização do trabalho docente à luz da responsabilidade social da educação superior

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Adolfo Ignacio Calderón

Full Text Available O artigo apresenta a discussão da compreensão da terceirização do trabalho docente no ensino superior privado, realizado por meio de cooperativas de mão de obra, à luz da responsabilidade social da educação superior. Conceitualiza a responsabilidade social, privilegiando duas abordagens: a normativa, de ordem legal, e a ética, direcionada ao desenvolvimento humano. Examina a coerência ética que deve existir na gestão universitária no equacionamento das exigências de maximização de recursos visando a ganhos de competitividade, com os princípios e valores que deveriam nortear os empreendimentos educacionais dentro de um cenário marcado pelas exigências e demandas do Estado e da sociedade por uma maior responsabilidade social da educação superior, principalmente do setor privado.

Profile Triglycerides Japanese Quail (Coturnix coturnix japonica After Giving Turmeric (Curcuma longa Powder

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Sukarman Hadi jaya Putra

2014-12-01

Full Text Available The purpose of this study was to determine the triglyceride profile of Japanese quail (Coturnix coturnix japonica after being given the parameters of turmeric (Curcuma longa powder; feed intake, profiles of liver triglycerides, profiles of serum triglycerides and profiles of meat triglycerides. This study uses an experimental method with A Completely Randomized Design Pattern. Test animals used were 45 female Japanese quails were divided into 3 groups, namely; P0: quail were not given turmeric powder, P1: quail were given turmeric powder a dose of 54 mg/quail/day, P3: quail were given turmeric powder a dose of 108 mg/quail/day. Each group with 5 replications. Each repeat consists of 3 Japanese quails. Provision of treatment every day for 30 days starting from the age of 14 days. Data were analyzed using analysis of variance (ANOVA followed by Duncan's test with 95% confidence interval (α = 0.05 level. Analysis of the data used is software Minitab software 16. Results showed that the levels of turmeric powder are given in Japanese quail significant (P˂0.05 on liver triglyceride levels, serum and Japanese quail meat but had no significant effect (P˃0.05 on consumption feed. The results showed that the optimal dose of turmeric powder to lower triglyceride levels of Japanese quail is 108 mg/quail/day as evidenced by the highest decrease in liver triglyceride profiles, profiles of serum triglycerides and triglyceride profiles of Japanese quail meat compared with other treatments.

Fourier transform infrared spectroscopy combined with chemometrics for discrimination of Curcuma longa, Curcuma xanthorrhiza and Zingiber cassumunar

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Rohaeti, Eti; Rafi, Mohamad; Syafitri, Utami Dyah; Heryanto, Rudi

2015-02-01

Turmeric (Curcuma longa), java turmeric (Curcuma xanthorrhiza) and cassumunar ginger (Zingiber cassumunar) are widely used in traditional Indonesian medicines (jamu). They have similar color for their rhizome and possess some similar uses, so it is possible to substitute one for the other. The identification and discrimination of these closely-related plants is a crucial task to ensure the quality of the raw materials. Therefore, an analytical method which is rapid, simple and accurate for discriminating these species using Fourier transform infrared spectroscopy (FTIR) combined with some chemometrics methods was developed. FTIR spectra were acquired in the mid-IR region (4000-400 cm-1). Standard normal variate, first and second order derivative spectra were compared for the spectral data. Principal component analysis (PCA) and canonical variate analysis (CVA) were used for the classification of the three species. Samples could be discriminated by visual analysis of the FTIR spectra by using their marker bands. Discrimination of the three species was also possible through the combination of the pre-processed FTIR spectra with PCA and CVA, in which CVA gave clearer discrimination. Subsequently, the developed method could be used for the identification and discrimination of the three closely-related plant species.

Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides.

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Nguyen, Thi Thanh Hanh; Si, Jinbeom; Kang, Choongil; Chung, Byoungsang; Chung, Donghwa; Kim, Doman

2017-01-01

Curcuminoids from rhizomes of Curcuma longa possess various biological activities. However, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. In this study, curcuminoids extracted from turmeric powder using stevioside (Ste), rebaudioside A (RebA), or steviol glucosides (SG) were solubilized in water. The optimum extraction condition by Ste, RebA, or SG resulted in 11.3, 9.7, or 6.7mg/ml water soluble curcuminoids. Curcuminoids solubilized in water showed 80% stability at pH from 6.0 to 10.0 after 1week of storage at 25°C. The particle sizes of curcuminoids prepared with Ste, RebA, and SG were 110.8, 95.7, and 32.7nm, respectively. The water soluble turmeric extracts prepared with Ste, RebA, and SG showed the 2,2-diphenyl-1-picrylhydrazyl radical scavenging (SC50) activities of 127.6, 105.4, and 109.8μg/ml, and the inhibition activities (IC50) against NS2B-NS3(pro) from dengue virus type IV of 14.1, 24.0 and 15.3μg/ml, respectively. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Stability study of azithromycin in ophthalmic preparations

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Andréia de Haro Moreno

2009-06-01

Full Text Available A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3 for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 µg/mL. The study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA.O estudo de estabilidade de azitromicina em preparações oftálmicas foi realizado após exposição a diferentes tipos de luz, temperatura e pH, utilizando o método de difusão em ágar (cilindros 3 x 3 para as quantificações. A faixa de concentração foi de 50 a 200 µg/mL. O estudo demonstrou que o fármaco sofreu degradação quando submetido às luzes ultravioleta, germicida e solar, e a soluções ácida, alcalina e de peróxido de hidrogênio. Os resultados foram analisados através da análise da variância (ANOVA.

Desarrollo de un sistema de transformación genética en Paracoccidioides brasiliensis

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Mauricio Corredor

2001-04-01

Full Text Available

La transformación genética es una alternativa para el conocimiento de genes involucrados en la patogenicidad de los hongos. A la fecha se han transformado algunos hongos utilizando técnicas como luz ultravioleta para obtener mutantes auxotróficas. Así mismo, se ha empleado la transformación basada en la introducción de plásmidos que confieren resistencia a antibióticos bien sea por medio de electroporación o imitando un evento que se presenta naturalmente entre plantas y el bacilo gram negativo Agrobacterium tumefaciens y que consiste en la transferencia del T-DNA del plásmido Ti bacteriano a la célula vegetal, con la consecuente aparición de un tumor en el tallo de
la planta. Este mecanismo se ha reproducido con éxito en hongos
filamentosos y en levaduras. En el caso de Paraco ccidioides brasiliensis aún no se dispone de un modelo de transformación. Considerando esta carencia y la necesidad de conocer los genes involucrados en la patogenicidad de este microorganismo, pretendemos desarrollar un sistema de transformación genética para P. brasiliensis utilizando A. tumefaciens.

Respuesta fotosintética de Eucalyptus grandis W. Hill a la disponibilidad de agua en el suelo y a la intensidad de luz

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María Sara Mejía de Tafur

2014-12-01

Full Text Available En condiciones de campo en la Universidad Nacional de Colombia sede Palmira (950 m.s.n.m., 24°C y 75% de humedad relativa se evaluó la respuesta fotosintética de cuatro clones de Eucalyptus grandis (28-3, 18-3, 24A-5, 19-1 al estrés hídrico: capacidad de campo (1 cc, 0.5 cc, 0.25 cc y a la saturación de agua e intensidades lumínicas variables de 1500, 1000, 500, 250, y 0 µmol/m²/s en el primer ensayo y de 1500, 1000, 435, 87, 70, 52, 35, 26, y 0 µmol/m²/s en el segundo. En ambos estudios, se utilizó un diseño experimental de parcelas divididas con cuatro repeticiones, donde la parcela principal correspondió al nivel de humedad en el suelo y la subparcela a los clones. El análisis estadístico mostró que E. grandis reduce la tasa de fotosíntesis de manera significativa cuando se presenta estrés hídrico en el suelo y que el grado de la respuesta depende del clon, lo que sugiere la presencia de mecanismos fisiológicos dependientes del genotipo para responder al estrés hídrico. Se presentaron curvas de luz típicas con puntos de compensación bajos (0.9 - 7.0 µmol/m²/s, tasas de fotosíntesis altas (68 - 39 µmol CO2 /m²/s y alta eficiencia fotosintética (0.0003 - 0.0086 mol CO2 /mol luz

Spatial localisation of curcumin and rapid screening of the chemical compositions of turmeric rhizomes (Curcuma longa Linn.) using Direct Analysis in Real Time-Mass Spectrometry (DART-MS).

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Rahman, A F M Motiur; Angawi, Rihab F; Kadi, Adnan A

2015-04-15

Curcumin is a potent antioxidant agent having versatile biological activities is present in turmeric rhizomes (Curcuma longa Linn.). Powder of turmeric rhizomes is consumes as curry spicy worldwide, especially in Asia. In this study, we demonstrate that, bioactive curcumin and its analog demethoxycurcumin are chiefly concentrated in the pith rather than the other parts of the turmeric rhizomes and it was discovered using modern atmospheric ionisation source 'Direct Analysis in Real Time' (DART) connected with an Ion Trap Mass Spectrometry. In addition, all the major components present in turmeric rhizomes were detected in positive and/or in negative ion mode using DART. Copyright © 2014 Elsevier Ltd. All rights reserved.

Effect of turmeric powder (Curcuma longa L.) and ascorbic acid on physical characteristics and oxidative status of fresh and stored rabbit burgers.

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Mancini, Simone; Preziuso, Giovanna; Dal Bosco, Alessandro; Roscini, Valentina; Szendrő, Zsolt; Fratini, Filippo; Paci, Gisella

2015-12-01

The objective of this study was to evaluate the effect of Curcuma longa powder and ascorbic acid on some quality traits of rabbit burgers. The burgers (burgers control with no additives; burgers with 3.5 g of turmeric powder/100g meat; burgers with 0.1g of ascorbic acid/100g meat) were analyzed at Days 0 and 7 for pH, color, drip loss, cooking loss, fatty acid profile, TBARS, antioxidant capacity (ABTS, DPPH and FRAP) and microbial growth. The addition of turmeric powder modified the meat color, produced an antioxidant capacity similar to ascorbic acid and determined a lower cooking loss than other formulations. Turmeric powder might be considered as a useful natural antioxidant, increasing the quality and extending the shelf life of rabbit burgers. Copyright © 2015 Elsevier Ltd. All rights reserved.

Application of Scion image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa).

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Sotanaphun, Uthai; Phattanawasin, Panadda; Sriphong, Lawan

2009-01-01

Curcumin, desmethoxycurcumin and bisdesmethoxycurcumin are bioactive constituents of turmeric (Curcuma longa). Owing to their different potency, quality control of turmeric based on the content of each curcuminoid is more reliable than that based on total curcuminoids. However, to perform such an assay, high-cost instrument is needed. To develop a simple and low-cost method for the simultaneous quantification of three curcuminoids in turmeric using TLC and the public-domain software Scion Image. The image of a TLC chromatogram of turmeric extract was recorded using a digital scanner. The density of the TLC spot of each curcuminoid was analysed by the Scion Image software. The density value was transformed to concentration by comparison with the calibration curve of standard curcuminoids developed on the same TLC plate. The polynomial regression data for all curcuminoids showed good linear relationship with R(2) > 0.99 in the concentration range of 0.375-6 microg/spot. The limits of detection and quantitation were 43-73 and 143-242 ng/spot, respectively. The method gave adequate precision, accuracy and recovery. The contents of each curcuminoid determined using this method were not significantly different from those determined using the TLC densitometric method. TLC image analysis using Scion Image is shown to be a reliable method for the simultaneous analysis of the content of each curcuminoid in turmeric.

Isolation and characterization of iron chelators from turmeric (Curcuma longa): selective metal binding by curcuminoids.

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Messner, Donald J; Surrago, Christine; Fiordalisi, Celia; Chung, Wing Yin; Kowdley, Kris V

2017-10-01

Iron overload disorders may be treated by chelation therapy. This study describes a novel method for isolating iron chelators from complex mixtures including plant extracts. We demonstrate the one-step isolation of curcuminoids from turmeric, the medicinal food spice derived from Curcuma longa. The method uses iron-nitrilotriacetic acid (NTA)-agarose, to which curcumin binds rapidly, specifically, and reversibly. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin each bound iron-NTA-agarose with comparable affinities and a stoichiometry near 1. Analyses of binding efficiencies and purity demonstrated that curcuminoids comprise the primary iron binding compounds recovered from a crude turmeric extract. Competition of curcuminoid binding to the iron resin was used to characterize the metal binding site on curcumin and to detect iron binding by added chelators. Curcumin-Iron-NTA-agarose binding was inhibited by other metals with relative potency: (>90% inhibition) Cu 2+  ~ Al 3+  > Zn 2+  ≥ Ca 2+  ~ Mg 2+  ~ Mn 2+ (80% by addition of iron to the media; uptake was completely restored by desferoxamine. Ranking of metals by relative potencies for blocking curcumin uptake agreed with their relative potencies in blocking curcumin binding to iron-NTA-agarose. We conclude that curcumin can selectively bind toxic metals including iron in a physiological setting, and propose inhibition of curcumin binding to iron-NTA-agarose for iron chelator screening.

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

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Yue, Grace G. L.; Chan, Ben C. L.; Hon, Po-Ming; Lee, Mavis Y. H.; Fung, Kwok-Pui; Leung, Ping-Chung; Lau, Clara B. S.

2010-01-01

The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (3 curcuminoids and 2 turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0–41.8 μg/ml. Alpha-turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V & propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone were shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. PMID:20438793

Differential effect of soil and environment on metabolic expression of turmeric (Curcuma longa cv. Roma).

Science.gov (United States)

Sandeep, I S; Sanghamitra, Nayak; Sujata, Mohanty

2015-06-01

Curcuma longa (Zingiberaceae) is known for its uses in medicine, cosmetics, food flavouring and textile industries. The secondary metabolites of turmeric like essential oil, oleoresin and curcumin are important for its multipurpose uses. These traits of turmeric vary from place to place due to the influence of environment, soil and agro-climatic conditions. Here, we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals. A high curcumin yielding cultivar i.e., Roma was collected from high altitude research station, Koraput (HARS) and planted in nine agroclimatic regions of Odisha. Analysis of soil texture, pH, organic carbon, micro and macro nutrients were done from all the studied zones up to 2nd generation. Plants grown in their released station i.e., Eastern Ghat High Land showed 5% of curcumin and were taken as control. Plants grown in different agroclimatic zones showed a range of 1.4-5% of curcumin and 0.3-0.7% of rhizome essential oil and 0.3-1% of leaf essential oil content. Gas chromatography and mass spectra analysis showed tumerone and alpha phellandrene as the major compounds in all the zones with 10-20% variation. The present study will be immensely helpful for standardization and management of environmental and ecological factors for high phytochemical yield in turmeric plant.

The positive impact of 'Luz do Campo' program in a rural area: the sericulture in Ribeirao Claro, Parana, Brazil; O impacto positivo do programa 'Luz do campo' na extensao rural: a sericicultura em Ribeirao Claro, Parana, Brazil

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Carmo, Jose R. do; Marques, Rui Manuel B.S.; Betiol Junior, Genesio [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-Graduacao e Energia], e-mail: jrcarmo@iee.usp.br, e-mail: rmanuel@iee.usp.br, e-mail: genesio.betiol@poli.usp.br; Ribeiro, Fernando Selles [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica de Engenharia], e-mail: fribeiro@pea.usp.br

2004-07-01

The 'Luz do Campo' program has created positive and favorable impact to the opening of opportunities in the rural area. It has contributed to facilitate the access of workers to energetic facilities and has contributed to providing them with better social and economical conditions. As a consequence after the accomplishment of the rural electrification process in the settlements of 'Anhumas' and 'Maria Neto' implanted in Ribeirao Claro in Parana, it was possible to come to terms with two projects of Sericiculture in that location. The energy consumption of these projects has not been only restricted to human comfort, but has also been aimed at the production. As a result, the economical success achieved in those settlements in less than a year's time, is due to the transformation actions in the countryside that have lowered poverty and raised the perspectives of better life quality to the settlers. (author)

Germination of seeds of the invasive plant Sesbania virgata (cav. pers. under effects of light, temperature, and dormancy overcoming Germinação de sementes da invasora Sesbania virgata (cav. pers. sob efeito de luz, temperatura e superação de dormência

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Irenice Gomes de Oliveira

2010-12-01

Full Text Available The work had as objectives to evaluate the influence of the light, temperature, and chemical scarification on the germination of seeds of S. virgata, species still little studied and that is invasive in several niches of the caatinga ecosystem. The seeds of S. virgata were collected in the municipal district of Natuba-PB in March/2008. Eight treatments were used as follows: intact seeds in the presence and absence of light, at 25ºC; intact seeds in the presence and absence of light, at 30ºC; submerged seeds in sulfuric acid for five minutes in the presence and absence of light, at 25ºC; submerged seeds in sulfuric acid for five minutes in the presence and absence of light, at 30ºC. The germination tests were accomplished in germination cameras under light and continuous darkness at constant temperatures of 25ºC and 30ºC, in a 12 hours photoperiod. The seeds were put to germinate in plastic boxes (gerbox with filter paper. The seeds of S. virgata have tegument dormancy and show low germination tax when intact, which is a strategy for seed banks formation. The acid scarification increased germination percentage and speed germination index. Este trabalho teve como objetivos avaliar a influência da luz, da temperatura e da escarificação química sobre a germinação de sementes de S. virgata, espécie ainda pouco estudada e que se constata invasora em diversos nichos do bioma Caatinga. Sementes de S. virgata foram coletadas no município de Natuba-PB em março de 2008 e submetidas a oito tratamentos, descritos a seguir: sementes intactas, na presença e ausência de luz, a 25ºC; sementes intactas na presença e ausência de luz, a 30ºC; sementes imersas em ácido sulfúrico por cinco minutos na presença e ausência de luz, a 25ºC; sementes imersas em ácido sulfúrico por cinco minutos na presença e ausência de luz, a 30ºC. Para estimar os efeitos dos tratamentos foram realizados testes de germinação em câmaras de germinação sob

Análisis Diagnóstico de la ecoaldea Aldeafeliz y propuesta de solución a la luz del Paradigma del Desarrollo a Escala Humana

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Amaya Amaya, Juan Sebastian

2014-01-01

El interés de este análisis diagnóstico es examinar, dentro de la nueva ruralidad, los niveles de calidad de vida en un tipo particular de asentamiento denominado ecoaldea. Para ello se realiza una inmersión en campo por medio de la construcción de una bitácora –etnografía-, para luego describir y analizar como se satisfacen las necesidades humanas en la ecoaldea Aldeafeliz (2006-2013) a la luz del Paradigma del Desarrollo a Escala Humana y el concepto mismo de ecoaldea, ent...

Use of Bidens pilosa L. (Asteraceae and Curcuma longa L. (Zingiberaceae to treat intestinal mucositis in mice: Toxico-pharmacological evaluations

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Carla Caroline Cunha Bastos

Full Text Available Introduction: Several studies towards the development of an effective treatment for intestinal mucositis have been reported, since this condition represents a major problem in clinical oncology practice due to cytotoxic effects of chemotherapy. However standardized protocols and universally accepted treatment options are yet to be established. Objectives: Given above, this study evaluated the protective effects of a mucoadhesive formulation containing both Bidens pilosa L. (Asteraceae (BP and curcuminoids from Curcuma longa L. (Zingiberaceae (CL on intestinal mucositis induced by 5-fluoruoacil (5-FU in mice. Results: As expected, animals only treated with 5-FU (200 mg/kg showed a significant reduction of 60.3 and 42.4% in villi and crypts size, respectively, when compared to control. On the other hand, the proposed therapeutic/prophylactic treatment with mucoadhesive formulations managed to reduce histopathologic changes in mice bearing mucositis, especially at 125 mg/kg BP + 15 mg/kg CL dose. The formulation promoted an increase of 275.5% and 148.7% for villi and crypts size, respectively. Moreover, chemotherapy-related weight loss was reduced by 7.4% following the treatment. In addition, an increase of 10 and 30.5% in red and white blood cells was observed when compared to 5-FU group. Furthermore, treatments with the mucoadhesive formulation containing BP/CL up modulated Ki-67 and Bcl-2 expression while reduced pro-apoptotic regulator Bax. The formulation also modulated inflammatory response triggered by 5-FU through reduction of 68% of myeloperoxidase activity and a 4-fold increase in anti-inflammatory IL-10 levels. In parallel, the oxidative stress via lipid peroxidation was reduced as indicated by decrease of 63% of malondialdehyde concentrations. Additionally, the new formulation presented low acute oral systemic toxicity, being classified in the category 5 (2000 mg/kg < LD50 < 5000 mg/kg of the Globally Harmonized

Fluorescent ligand fishing combination with in-situ imaging and characterizing to screen Hsp 90 inhibitors from Curcuma longa L. based on InP/ZnS quantum dots embedded mesoporous nanoparticles.

Science.gov (United States)

Hu, Yue; Fu, Anchen; Miao, Zhaoyi; Zhang, Xiaojing; Wang, Tianlin; Kang, An; Shan, Jinjun; Zhu, Dong; Li, Wei

2018-02-01

Although ligand fishing has been shown to be an efficient technique for the identification of bioactive components from complex mixtures such as natural products, it cannot be applied to biomedical image processing. Herein, a specific fluorescent ligand fishing combined with in situ imaging approach is presented for the identification of heat shock protein 90 (Hsp 90) inhibitors from complex matrixes, Curcuma longa L., using N-terminus immobilized Hsp 90α functionalized InP/ZnS quantum dots embedded mesoporous nanoparticles (i.e. Hsp 90α (NT)-FQDNs) as extraction sorbents and fluorescent tracer. The fished ligands were identified by liquid chromatography time-of-flight/mass spectrometry (LC-TOF/MS) and gas chromatography-mass spectrometry (GC-MS). Moreover, in situ imaging by confocal laser scanning microscopy (CLSM) was applied for evaluating the effect of fished-ligands on bioactivity-induced apoptosis morphologically in HeLa cells. MTT assay verified the bioactivity of the ligands and molecular docking results further provided convincing information to verify the feasible binding mode between ligands and protein. Twelve ligands as potential Hsp 90 inhibitors were ultimately fished and identified from Curcuma longa L. crude extracts. The proposed approach based on Hsp 90α functionalized nanocomposites is superior in the combination of highly specific screening efficiency and concurrent visual in situ imaging, which could have great promise for the development of other plant-derived Hsp 90 inhibitors, and providing a rapid and reliable platform for discovering biologically active molecules in natural products. Copyright © 2017 Elsevier B.V. All rights reserved.

Gerontotecnologia educativa voltada ao idoso estomizado à luz da complexidade Gerontotecnología educativa para el adulto mayor ostomizado a la luz de la complejidad Educational geronto-technology for ostomized seniors from a complexity perspective

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Edaiane Joana Lima Barros

2012-06-01

Full Text Available Objetivou-se apresentar a cartilha educativa como um produto gerontotecnológico útil para o cuidado ao idoso estomizado à luz da complexidade. O trabalho foi realizado, no segundo semestre de 2007, em um hospital universitário do sul do Brasil. Os dados foram coletados através de entrevistas e apresentados na forma de uma cartilha educativa. Esta foi validada por idosos estomizados e por uma enfermeira atuante na área há mais de dezesseis anos. A cartilha apresentou-se como uma gerontotecnologia capaz de facilitar a compreensão da pessoa idosa estomizada e seu familiar sobre os direitos dos estomizados, conceitos e tipos de estomas, cuidados com a estomia e importância da família e do grupo de apoio para o cuidado. Conclui-se que a cartilha educativa apresenta-se como mais um instrumento de promoção da saúde, facilitador do processo educativo em saúde, tornando a pessoa idosa estomizada copartícipe do seu cuidado.Este trabajo tuvo por objetivo presentar el folleto educativo como un producto gerontotecnológico para el cuidado del adulto mayor ostomizado a la luz de la Complejidad. Fue realizado en el segundo semestre de 2007 en un hospital en el sur de Brasil. Los datos fueron recolectados a través de entrevistas y presentado como un folleto educativo. El folleto fue validado por los adultos mayores ostomizados y una enfermera actuante en el área. El folleto fue presentado como una gerontotecnología capaz de facilitar la comprensión de la persona anciana y sus familiares sobre los derechos del ostomizado; conceptos y tipos de estomas; cuidados con la ostomía y la importancia de la familia y del grupo de apoyo para el cuidado. Se concluye que el folleto educativo se presenta como una herramienta facilitadora de promoción de la salud del proceso educativo en salud que hace del adulto mayor ostomizado coparticipante en su cuidado.We aimed to present the educational booklet as a geronto-technological product for caring for

Um sopro de Luz e Letra em meio ao caos

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Marcelo Tomazi

2009-06-01

Full Text Available Enquanto compreende avanços científicos, o homem busca compreender a si mesmo. Partindo da citação de Carl Sagan, vemos que a Arte é um dos caminhos para a humanização, e os vínculos entre ciência (tecnologia e arte são cada vez mais estreitos. Um dos artistas que melhor trabalham dentro do nicho conhecido como “arte tecnológica” é Eduardo Kac. Sua trajetória inicial é apresentada aqui, dos “holopoemas” à “arte da telepresença”. Vemos o artista-teórico completo, profundo conhecedor da história da arte eletrônica. O livro Luz & letra: ensaios de arte, literatura e comunicação, sua obra de referência, é apresentado em essência, situando-se sua importância. É uma das poucas obras no Brasil a discutir, pela ótica de quem fez parte, eventos ligados ao advento da arte tecnológica nos anos 1980.In our quest to understand scientific advances, we seek to understand ourselves. Employing Carl Sagan's insight as a departure point, we see that art is one of the paths for humanization and that the links between science (technology and art are increasingly narrow. One of the artists who best works within the realm known as “art and technology” is Eduardo Kac. This essay explores Kac's early artworks, starting with “holopoems” and arriving at “telepresence art”, and especially his texts. We see a complete artist-theorist, with an unrivaled knowledge of electronic art and literature, in part because his theorizing emerges from having actively participated in the creation of the events he refers to. Of special interest is Kac's book Light & letter: essays in art, literature, and communication, which collects his writings of the 1980s. This is a fundamental work and mandatory reference for the study of the experimental art and literature of the period.

Optimization of Microwave-Assisted Extraction of Curcumin From Curcuma longa L. (Turmeric and Evaluation of Antioxidant Activity in Multi-Test Systems

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Mustafa Bener

2016-03-01

Full Text Available Turmeric ( Curcuma longa L. is a medicinal plant, and its biological activities mainly arise from the main constituent, known as diferuloylmethane or curcumin. In the present paper, microwave-assisted extraction (MAE was investigated for the recovery of curcumin from turmeric in comparison to conventional heat-assisted extraction (CHAE technique. Various experimental conditions, such as solvent concentration (0-100%, v/v, MAE temperature (30-130 oC and MAE time (0-20 min were investigated to optimize the extraction of curcumin from turmeric. The identification and quantification of curcumin in extracts were performed by HPLC-DAD system. Antioxidant potential and radical scavenging abilities of microwave-assisted extract and conventional heat-assisted extract of turmeric (MAET and CHAET were evaluated using different systems including total phenolic content (TPC, total antioxidant capacity (TAC, and radical scavenging activities. MAET and CHAET showed high antioxidant activity in all test systems, but the antioxidant properties of MAET were stronger than those of CHAET.

Detecção de emissão espontânea de luz em ensaios de colimetria aplicados ao monitoramento de efluentes sanitários Spontaneous light emission in coliforms test applied to wastewater monitoring

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Samuel Ricardo dos Santos

2011-03-01

Full Text Available No presente trabalho avaliou-se o potencial do emprego da técnica biofotônica ao monitoramento da qualidade microbiológica de efluentes sanitários, por meio da detecção de emissão ultrafraca de luz em testes envolvendo bactéria do grupo coliforme. Foram acompanhados os padrões de emissão de luz em câmara escura com o uso de efluente doméstico, antes e após tratamento, incubados em meio nutritivo à base de lactose e lauril triptose. O controle foi efetuado com o uso de cepa de Escherichia coli (ATCC 25.922, tendo seu crescimento sido monitorado por emissão de luz em câmara escura com fotomultiplicador acoplado. Os dados demonstraram que o monitoramento microbiológico pode ser efetuado por meio técnica biofotônica, podendo ser aplicado, com respostas rápidas, ao monitoramento microbiológico de efluentes, por meio de testes envolvendo coliformes.The spontaneous light emission of living systems emerge as a promising methodology that applied to microbiological in monitoring water can lead to short-term analysis. The present study evaluated the potential of biophoton measurements applied to wastewater monitoring by using ultraweak light emission in coliform tests. The procedure is based on photon-counting measurements inside a dark-chamber, of wastewater samples, before and after treatment, inoculated in nutrient presence/absence medium (lactose and lauryl triptose broth. Strain of Escherichia coli (ATCC 25,922 was used in control tests by monitoring the light emission inside a dark-chamber with an acoplade photomultiplier. The data showed that microbiological monitoring can be done by photon-counting in real-time applied to microbiological wastewater monitoring using coliform test.

Explorando luz solar en modelos de desarrollo inmobiliario. Aplicaciones en cinco ciudades chilenas.

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Luz Alicia Cárdenas Jirón

2016-06-01

Full Text Available El explosivo crecimiento del stock edificado de los últimos años en las ciudades chilenas se ha visto reflejado en concentraciones inmobiliarias de gran altura, que irrumpen estrepitosamente en la morfología de las ciudades chilenas. Externalidades son observadas en los espacios y edificios vecinos tales como extensas áreas de sombreamiento que afectan las condiciones térmicas y lumínicas. Estas construcciones se realizan aparentemente acordes a la norma urbanística, pero afectan la luz solar incidente en fachadas y suelos, disminuyendo las posibilidades de captación y su uso como energía renovable. El objetivo del presente artículo es explorar mediante modelos espaciales –energéticos, distintas formas de ocupación de suelo, cambiando la altura edificada, pero manteniendo la constructibilidad en cinco ciudades chilenas. Las ciudades seleccionadas se sitúan en el centro sur de Chile, emplazadas tanto en el borde costero como el valle central y han presentado crecimientos inmobiliarios importantes en los últimos años. Los resultados muestran valores de energía más elevados en configuraciones de mayor altura, y menores valores relativos a medida que asciende latitudinalmente. El modelo básico ha sido una manzana de 1 ha como punto de partida, por tanto los resultados no son aplicables a un tejido urbano que es más complejo.

Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats.

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Sharma, Sameer; Kulkarni, Shrinivas K; Chopra, Kanwaljit

2006-10-01

Chronic hyperglycaemia in diabetes leads to the overproduction of free radicals and evidence is increasing that these contribute to the development of diabetic nephropathy. Among the spices, turmeric (Curcuma longa) is used as a flavouring and colouring agent in the indian diet every day and is known to possess anti-oxidant properties. The present study was designed to examine the effect of curcumin, a yellow pigment of turmeric, on renal function and oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ (65 mg/kg) in rats. Four weeks after STZ injection, rats were divided into four groups, namely control rats, diabetic rats and diabetic rats treated with curcumin (15 and 30 mg/kg, p.o.) for 2 weeks. Renal function was assessed by creatinine, blood urea nitrogen, creatinine and urea clearance and urine albumin excretion. Oxidative stress was measured by renal malonaldehyde, reduced glutathione and the anti-oxidant enzymes superoxide dismutase and catalase. Streptozotocin-injected rats showed significant increases in blood glucose, polyuria and a decrease in bodyweight compared with age-matched control rats. After 6 weeks, diabetic rats also exhibited renal dysfunction, as evidenced by reduced creatinine and urea clearance and proteinuria, along with a marked increase in oxidative stress, as determined by lipid peroxidation and activities of key anti-oxidant enzymes. Chronic treatment with curcumin significantly attenuated both renal dysfunction and oxidative stress in diabetic rats. These results provide confirmatory evidence of oxidative stress in diabetic nephropathy and point towards the possible anti-oxidative mechanism being responsible for the nephroprotective action of curcumin.

Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp.

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Liu, Yan-Meng; Zhang, Qi-Zhong; Xu, De-Hai; Fu, Yao-Wu; Lin, De-Jie; Zhou, Sheng-Yu; Li, Jian-Pei

2017-03-15

Ichthyophthirius multifiliis is a ciliated parasite that elicits great economic losses in aquaculture. In the present study, a polyphenol compound, curcumin, was obtained from the rhizome of Curcuma longa by bioassay-guided isolation based on the efficacy of anti-I. multifiliis theronts. Anti-I. multifiliis efficacy of curcumin was evaluated in vitro and in vivo. Curcumin resulted in 100% mortality of I. multifiliis theronts at a concentration of 1mg/L within 21.7±1.2min and killed all tomonts at 8mg/L within 31.0±1.0min. Curcumin at 4mg/L for 16h exposure can completely terminate the reproduction of tomonts. The pretreatment with curcumin at concentrations of 0.5, 0.25, and 0.125mg/L for 2h significantly reduced the infectivity of I. multifiliis theronts. Curcumin at 4mg/L completely cured the infected grass carp and protected naive fish from I. multifiliis infection after 10days exposure. The 4h median effective concentration (EC 50 ) of curcumin to I. multifiliis theronts and the 5h EC 50 of curcumin to I. multifiliis tomonts were 0.303mg/L and 2.891mg/L, respectively. The 96h median lethal concentration (LC 50 ) of curcumin to grass carp was 56.8mg/L, which was approximately 187.4 times EC 50 of curcumin to theronts and 19.6 times EC 50 of curcumin to tomonts. The results demonstrated that curcumin has the potential to be a safe and effective therapeutant for controlling ichthyophthiriasis in aquaculture. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluación del desempeño de cajas portátiles de procesamiento radiográfico en la filtración de luz

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Ferreira Costa, André Luis; Montebello-Filho, Agenor; Ambrosano Bovi, Glaucia; Ortega Villalobos, Ana Isabel

2006-01-01

Este estudio evaluó el desempeño de cajas portátiles de procesamiento radiográfico (CPR) a través del efecto de la luz filtrada por el acrílico empleado en la construcción de las mismas, sobre la densidad base-velamiento (DBV) de radiografías intrabucales. Fueron expuestas a los rayos X, películas radiográficas en conjunto con una lámina de plomo de 4mm de espesor para obtener un área no sensibilizada a la radiación en la radiografía resultante y así determinar la DBV. Posteriormente, las pel...

The neuroprotective effects of an ethanolic turmeric (Curcuma longa L.) extract against trimethyltin-induced oxidative stress in rats.

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Yuliani, Sapto; Mustofa; Partadiredja, Ginus

2018-03-07

Oxidative stress is known to contribute to the pathogenesis of neurodegenerative disorders. An ethanolic turmeric (Curcuma longa L.) extract containing curcumin has been reported to produce antioxidant effects. The present study aims to investigate the possible neuroprotective effects of the ethanolic turmeric extract against trimethyltin (TMT)-induced oxidative stress in Sprague Dawley rats. The ethanolic turmeric extract and citicoline were administered to the TMT exposed rats from day 1 to day 28 of the experiment. The TMT injection was administered on day 8 of the experiment. The plasma and brain malondialdehyde (MDA) and reduced glutathione (GSH) levels, and the activities of the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzymes in the brain were examined at the end of the experiment. The administration of 200 mg/kg bw of the ethanolic turmeric extract prevented oxidative stress by decreasing the plasma and brain MDA levels and increasing the SOD, CAT, and GPx enzyme activities and GSH levels in the brain. These effects seem to be comparable to those of citicoline. The ethanolic turmeric extract at a dose of 200 mg/kg bw may exert neuroprotective effects on TMT-exposed Sprague Dawley rats by preventing them from oxidative stress.

Estudio del efecto fotocrómico que presentan los vidriados opacificados por esfena

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Gimeno, R.

2012-04-01

Full Text Available White glazes opacified by sphene, based on the system SiO₂-CaO-TiO₂, are an alternative to the glazes in which the opacifying phase is zircon. However, it has been observed that this type of glaze displays photochromism (reversible change of colour after exposure to a light source, involving the appearance of a yellowish shade after the glaze has been subjected to sunlight for several hours, which then disappears after a few days. This effect has led to limited use of this type of glaze. In this study, a method of quantifying the photochromic effect by means of a UV light source is established. The microstructural characterisation of glazes with a pronounced tendency to display a photochromic effect has allowed the possible causes of the photochromic effect to be determined. Finally, a series of tests have been conducted that show that the photochromic effect is related to the impurities present in the glaze, as well as to the type and quantity of crystalline phases contained in the glaze.

Los vidriados blancos opacificados por esfena, basados en el sistema SiO₂-CaO-TiO₂, son una alternativa a los vidriados en los que la fase opacificante es el circón. Sin embargo, se ha observado que este tipo de vidriados presentan fotocromismo (cambio de color reversible tras la exposición a una fuente de luz, el cual consiste en la aparición de una tonalidad amarillenta tras someter el vidriado a la luz solar durante varias horas, que desaparece al cabo de varios días. Este efecto hace que la utilización de este tipo de vidriados no se haya generalizado. En el presente trabajo se establece un método para la cuantificación del efecto fotocrómico mediante el uso de una fuente de luz ultravioleta. La caracterización microestructural de vidriados con distinta tendencia a presentar el efecto fotocrómico ha permitido establecer las posibles causas que provocan el efecto fotocrómico. Finalmente, se

Discusión y evaluación de fuentes de luz artificial para la caracterización de dispositivos fotovoltaicos

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Wendy Reyes-Rojas

2014-12-01

Este trabajo se enfocó en analizar los efectos del método de alimentación eléctrica de las bombillas sobre la estabilidad de la luz emitida, la relación entre los cambios de tensión y la intensidad lumínica lograda, y las implicaciones que la potencia disipada pueda tener sobre la distribución espectral obtenida. Se encontró, principalmente, que el uso de tensión variable incide de manera negativa en la estabilidad de la emisión lumínica y, además, que la temperatura de operación del filamento juega un rol de suma importancia en el calentamiento que pueda experimentar el panel, así como en la proporción de energía emitida que el dispositivo fotovoltaico es capaz de aprovechar.

LA FORMACIÓN INVESTIGATIVA DE LOS ESTUDIANTES DEL PROGRAMA DE HUMANIDADES Y EDUCACIÓN DEL NÚCLEO LUZ COSTA ORIENTAL DEL LAGO

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Sunny Perozo

2013-04-01

Full Text Available El propósito de la investigación es describir la formación investigativa de los estudiantes del Programa Humanidades y Educación del Núcleo LUZ-COL, mediante un estudio descriptivo con un diseño de campo.  Teóricamente se sustenta en Tobon (2006, 2007,2009 y Hurtado (2010. La población está conformada por 38 estudiantes, a quienes se les aplica un cuestionario de  84 preguntas de. Los resultados con una media de 43,79 indican que los encuestados poseen un nivel medio de las dimensiones cognitivas, procedimentales y actitudinales en su formación investigativa, ante lo cual se infiere que enfrentan serias dificultades para el desarrollo del proceso de investigación.

Efeito da luz e da temperatura de congelamento sobre a estabilidade das antocianinas da pitanga roxa The effects of light and freezing temperature upon the stability of purple surinam cherry's anthocyanins

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Vera Lúcia Arroxelas G. de Lima

2005-03-01

Full Text Available As antocianinas são corantes naturais que podem ser utilizadas como alternativa em substituição aos corantes sintéticos. Entretanto, a baixa estabilidade destes compostos é o principal fator que dificulta sua aplicação como corante em alimentos. Frente à escassez de estudo sobre o pigmentos antociânicos da pitanga roxa, este trabalho teve como propósito avaliar a sua estabilidade à luz e ao congelamento. Utilizando a leitura de absorbância do extrato antociânico submetido às condições experimentais foi evidenciado que a luz reduziu o seu tempo de meia-vida, enquanto que a temperatura de congelamento exerceu pequeno efeito na degradação dos pigmentos.Anthocyanins are natural colorants that can be used as alternative to synthetic dyes. However, the low stability of these compounds is the main drawback in their application as food colorants. Since the information on anthocyanin pigments in Surinam cherry is scarce, the purpose of this investigation was to assess their stability to light and freezing storage. The anthocyanin extract absorbance, under the experimental conditions, showed that light incidence reduced the half-life of anthocyanin extract; meanwhile the freezing storage had little effect on these pigments degradation.

Curcuma longa (Turmeric) for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Pilot Study.

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Scontre, Vanessa Armenio; Martins, Janine Capobiango; de Melo Sette, Claudia Vaz; Mutti, Haila; Cubero, Daniel; Fonseca, Fernando; Del Giglio, Auro

2017-11-02

Hand-foot syndrome (HFS) is common and frequently occurs in the first cycle of treatment in approximately 40% to 50% of patients who receive capecitabine. Turmeric (Curcuma longa) is a plant used in Ayurvedic medicine with clinical activity in various inflammatory conditions. Our objective was to evaluate whether turmeric was active for the prevention of capecitabine-induced HFS. We included patients older than 18 years of age without previous exposure to capecitabine who were scheduled to receive this medication. Before starting treatment, after three weeks and at the end of six weeks, we evaluated dermatologic toxicity, conducted quality-of-life questionnaires (EORTC-QLQC30 and DLQI) and collected serum inflammatory biomarkers (inerleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), C-reactive protein (CRP), and albumin). We administered turmeric at a dose of 4 g/day (2 pills 12 hours apart) starting at the beginning of capecitabine treatment and lasting six weeks. We included 40 patients whose mean age was 62 years. Most were female (80%), 52% had breast cancer, and 47.5% had GI tumors. After the first cycle of capecitabine treatment, we observed that 11 of 40 patients developed HFS (27.5%; 95% CI [15, 42]), whereas four patients developed HFS equal or superior to grade 2 (10%; 95% CI [3.3, 23]). We did not find any correlations between the inflammatory markers tested and HFS. We show that turmeric combined with capecitabine seems to produce a lower rate of HFS, especially grade 2 or higher. These findings need to be reproduced in larger controlled studies.