International Nuclear Information System (INIS)
Dzhabishvili, N.A.; Davitashvili, E.G.; Orlovskij, V.P.; Kargareteli, L.N.
1986-01-01
Reaction between lutetium nitrate and pyrophosphates of sodium, potassium and ammonium in aqueous solution is studied, using the method of residual concentrations. New compounds are isolated, their composition and physicochemical properties are considered. Data on solubility in the systems at 25 deg C are given. All the hydrate pyrophosphates are roentgenoamorphous, they are crystallized only when heated. Thermal decomposition of lutetium pyrophosphate is investigated
Low temperature heat capacity of lutetium and lutetium hydrogen alloys
International Nuclear Information System (INIS)
Thome, D.K.
1977-10-01
The heat capacity of high purity electrotransport refined lutetium was measured between 1 and 20 0 K. Results for theta/sub D/ were in excellent agreement with theta values determined from elastic constant measurements. The heat capacity of a series of lutetium-hydrogen solid solution alloys was determined and results showed an increase in γ from 8.2 to about 11.3 mJ/g-atom-K 2 for hydrogen content increasing from zero to about one atomic percent. Above one percent hydrogen γ decreased with increasing hydrogen contents. The C/T data showed an increase with temperature decreasing below about 2.5 0 K for samples with 0.1 to 1.5 atomic percent hydrogen. This accounts for a large amount of scatter in theta/sub D/ versus hydrogen content in this range. The heat capacity of a bulk sample of lutetium dihydride was measured between 1 and 20 0 K and showed a large increase in theta/sub D/ and a large decrease in γ compared to pure lutetium
Lutetium oxide-based transparent ceramic scintillators
Seeley, Zachary; Cherepy, Nerine; Kuntz, Joshua; Payne, Stephen A.
2016-01-19
In one embodiment, a transparent ceramic of sintered nanoparticles includes gadolinium lutetium oxide doped with europium having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YEu.sub.YO.sub.3, where X is any value within a range from about 0.05 to about 0.45 and Y is any value within a range from about 0.01 to about 0.2, and where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm. In another embodiment, a transparent ceramic scintillator of sintered nanoparticles, includes a body of sintered nanoparticles including gadolinium lutetium oxide doped with a rare earth activator (RE) having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YRE.sub.YO.sub.3, where RE is selected from the group consisting of: Sm, Eu, Tb, and Dy, where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm.
Low-temperature thermal properties and features of the phonon spectrum of lutetium tetraboride
Energy Technology Data Exchange (ETDEWEB)
Novikov, V.V., E-mail: vvnovikov@mail.ru [Bryansk Petrovsky State University, 14 Bezhitskaya St., Bryansk 241037, Russia, (Russian Federation); Mitroshenkov, N.V., E-mail: weerm@yandex.ru [Bryansk Petrovsky State University, 14 Bezhitskaya St., Bryansk 241037, Russia, (Russian Federation); Matovnikov, A.V.; Avdashchenko, D.V. [Bryansk Petrovsky State University, 14 Bezhitskaya St., Bryansk 241037, Russia, (Russian Federation); Morozov, A.V. [Russian Timiryazev State Agrarian University, 49 Timiryazevskaya St., Moscow 127550 (Russian Federation); Pavlova, L.M.; Koltsov, V.B. [National Research University of Electronic Technology “MIET”, Moscow 124498 (Russian Federation)
2014-11-15
Highlights: • The coefficients of thermal expansion (α{sub ‖}, α{sub ⊥}) were measured for lutetium tetraboride. • The simplified Lutetium tetraboride phonon spectrum model is developed. • The Grüneisen parameters Γ, Γ{sub ‖}, Γ{sub ⊥} for lutetium tetraboride is calculated. • The anomalies of Γ{sub ‖}(T), Γ{sub ⊥}(T) at about 25 K are due to Einstein vibrations of boron sublattices. - Abstract: The coefficients of thermal expansion to the c axis (α{sub ‖}, α{sub ⊥}) were measured for lutetium tetraboride over the temperature range 4.2–300 K. The heat capacity data for lutetium tetraboride were used for the calculation of tetraboride phonon spectrum moments and also for the development of a simplified tetraboride spectrum model. The use of the heat capacity and thermal expansion data allowed the temperature changes of the Grüneisen parameters Γ, Γ{sub ‖}, Γ{sub ⊥} for tetraboride to be calculated. As a result of the approximation of Γ{sub ⊥}(T), Γ{sub ‖}(T) temperature dependencies in accordance with the chosen phonon spectrum model have been found: the anomalies of Γ{sub ⊥}(T), Γ{sub ‖}(T) are at about 25 K and then drop at lower temperatures due to the Einstein vibrations of boron sublattices.
International Nuclear Information System (INIS)
Klassen, Nikolay V.; Shmurak, Semion Z.; Shmyt'ko, Ivan M.; Strukova, Galina K.; Derenzo, Stephen E.; Weber, Marvin J.
2005-01-01
Lutetium and yttrium borates doped with europium, terbium, gadolinium, etc. have been synthesized by dissolving initial oxides and nitrates in ammonium nitrate melt and thermal decomposition of the solvent. Annealings in the range of 500-1100 deg. C modified the dimensions of the grains from 2 to 3 nm to more than 100 nm. Significant dependence of the structure of lutetium borate on slight doping with rare earth ions has been found: terbium makes high-temperature vaterite phase preferential at room temperature, whereas europium stabilizes low-temperature calcite phase. Influence of the structure of the borates on the pattern of the luminescence spectra of europium dopant was observed. Possibilities for manufacturing of scintillating lutetium borate ceramics by means of this method of synthesis are discussed
Klassen, Nikolay V.; Shmurak, Semion Z.; Shmyt'ko, Ivan M.; Strukova, Galina K.; Derenzo, Stephen E.; Weber, Marvin J.
2005-01-01
Lutetium and yttrium borates doped with europium, terbium, gadolinium, etc. have been synthesized by dissolving initial oxides and nitrates in ammonium nitrate melt and thermal decomposition of the solvent. Annealings in the range of 500-1100°C modified the dimensions of the grains from 2 to 3 nm to more than 100 nm. Significant dependence of the structure of lutetium borate on slight doping with rare earth ions has been found: terbium makes high-temperature vaterite phase preferential at room temperature, whereas europium stabilizes low-temperature calcite phase. Influence of the structure of the borates on the pattern of the luminescence spectra of europium dopant was observed. Possibilities for manufacturing of scintillating lutetium borate ceramics by means of this method of synthesis are discussed.
PMR investigation into complexes of lanthanum and lutetium with ethylenediaminediacetic acid
International Nuclear Information System (INIS)
Kostromina, N.A.; Novikova, L.B.
1975-01-01
Proton resonance spectra of ethylendiaminediacetic acid (EDDA) and EDDA mixtures with La and Lu as function of pH of solution was studied. Sequence of EDDA (A 2- ) protonation was established; cations H 3 A + and H 4 A 2+ were found; dissociation constants of above mentioned cations were determined. Formation of H 2 LnA 3+ , HLnA 2+ and LnA + complexes in EDDA-Ln (1:1) system was found. Difference in the bonds mobility of lanthanum and lutetium complexes was determined: lanthanum forms complexes with labile, lutetium with non-labile bonds. Information on complexes structure is collected. Acid dissociation constants of protonated complexes of lanthanum with EDDA were determined
Saturated vapor pressure of lutetium tris-acetylacetonate
Energy Technology Data Exchange (ETDEWEB)
Trembovetskij, G.V.; Berdonosov, S.S.; Murav' eva, I.A.; Martynenko, L.I. (Moskovskij Gosudarstvennyj Univ. (USSR))
1983-12-01
By the statical method using /sup 177/Lu radioactive isotope the saturated vapor pressure of anhydrous lutetium acetylacetonate at 130 to 160 deg is determined. The calculations are carried out assuming the vapor to be monomolecular. The equation of lgP versus 1/T takes the form: lg Psub((mmHg))=(8.7+-1.6)-(4110+-690)/T. The thermodynamical characteristics of LuA/sub 3/ sublimation are calculated to be ..delta..Hsub(subl.)=79+-13 kJ/mol; ..delta..Ssub(subl.)=111+-20 J/kxmol.
First principles study of electronic, elastic and thermal properties of lutetium intermetallics
International Nuclear Information System (INIS)
Pagare, Gitanjali; Chouhan, Sunil Singh; Soni, Pooja; Sanyal, S.P.; Rajagopalan, M.
2011-01-01
In the present work, the electronic, elastic and thermal properties of lutetium intermetallics LuX have been studied theoretically by using first principles calculations based on density functional theory (DFT) with the generalized gradient approximation (GCA)
International Nuclear Information System (INIS)
Wu, Hong; Engelhard, Mark H.; Wang, Jun; Fisher, Darrell R.; Lin, Yuehe
2008-01-01
We report a novel approach for synthesizing LuPO4/apoferritin core-shell nanoparticles based on an apoferritin template, conjugated to the protein biotin. To prepare the nanoparticle conjugates, we used non-radioactive lutetium as a model target or surrogate for radiolutetium (177Lu). The central cavity, multi-channel structure, and chemical properties of apoferritin are well-suited for sequentially diffusing lutetium and phosphate ions into the cavity--resulting in a stable core-shell composite. We characterized the synthesized LuPO4/apoferritin nanoparticle using transmission electron microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). We tested the pre-targeting capability of biotin-modified lutetium/apoferritin nanoparticle using streptavidin-modified magnetic beads and streptavidin-modified fluorescein isothiocyanate (FITC) tracer. This paper presents a simple, fast, and efficient method for synthesizing LuPO4/apoferritin nanoparticle conjugates with biotin for potential applications in radioimmunotherapy and radioimmunoimaging of cancer
Lutetium(III) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex
Energy Technology Data Exchange (ETDEWEB)
Sessa, Francesco; D’Angelo, Paola, E-mail: p.dangelo@uniroma1.it [Dipartimento di Chimica, Università di Roma “La Sapienza,” P. le A. Moro 5, 00185 Roma (Italy); Spezia, Riccardo [CNRS, UMR 8587, Laboratoire Analyse et Modelisation Pour la Biologie et l’Environnement, Université d’Evry Val d’Essonne, Blvd. F. Mitterrand, 91025 Evry Cedex (France)
2016-05-28
The structure and dynamics of the lutetium(III) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(III) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(III) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.
International Nuclear Information System (INIS)
Warmińska, Dorota; Wawer, Jarosław
2012-01-01
Highlights: ► Sequence of volumes and compressibilities of Ln 3+ ions in DMSO is: La 3+ > Gd 3+ 3+ . ► Sequence of the partial molar volumes do not change with temperature. ► These results are the consequence of nature of the ion–solvent bonding. - Abstract: Temperature dependencies of the densities of dimethylsulfoxide solutions of lanthanum, gadolinium and lutetium trifluoromethanesulfonates have been determined over a wide range of concentrations. The apparent molar volumes and partial molar volumes of the salts at infinite dilution, as well as the expansibilities of the salts, have been calculated from density data. Additionally, the apparent molar isentropic compressibilities of lanthanum, gadolinium and lutetium trifluoromethanesulfonates have been calculated from sound velocity data at 298.15 K. The data obtained have been interpreted in terms of ion−solvent interactions.
Determination of Kps and β1,H in a wide interval of initial concentrations of lutetium
International Nuclear Information System (INIS)
Lopez-G, H.; Jimenez R, M.; Solache R, M.; Rojas H, A.
2006-01-01
The solubility product constants and the first of lutetium hydrolysis in the interval of initial concentration of 3.72 X 10 -5 to 2.09 X 10 -3 M of lutetium, in a 2M of NaCIO 4 media, at 303 K and under conditions free of CO 2 its were considered. The solubility diagrams (pLu (ac) -pC H ) by means of a radiochemical method were obtained, and starting from its the pC H values that limit the saturation and no-saturation zones of the solutions were settled down. Those diagrams allowed, also, to calculate the solubility product constants of Lu(OH) 3 . The experimental data to the polynomial solubility equation were adjusted, what allowed to calculate those values of the solubility product constants of Lu(OH) 3 and to determine the first hydrolysis constant. The value of precipitation pC H diminishes when the initial concentration of the lutetium increases, while the values of K ps and β 1,H its remain constant. (Author)
Thermal decomposition of lutetium propionate
DEFF Research Database (Denmark)
Grivel, Jean-Claude
2010-01-01
The thermal decomposition of lutetium(III) propionate monohydrate (Lu(C2H5CO2)3·H2O) in argon was studied by means of thermogravimetry, differential thermal analysis, IR-spectroscopy and X-ray diffraction. Dehydration takes place around 90 °C. It is followed by the decomposition of the anhydrous...... °C. Full conversion to Lu2O3 is achieved at about 1000 °C. Whereas the temperatures and solid reaction products of the first two decomposition steps are similar to those previously reported for the thermal decomposition of lanthanum(III) propionate monohydrate, the final decomposition...... of the oxycarbonate to the rare-earth oxide proceeds in a different way, which is here reminiscent of the thermal decomposition path of Lu(C3H5O2)·2CO(NH2)2·2H2O...
Laser resonance ionization spectroscopy on lutetium for the MEDICIS project
Energy Technology Data Exchange (ETDEWEB)
Gadelshin, V., E-mail: gadelshin@uni-mainz.de [University of Mainz, Institute of Physics (Germany); Cocolios, T. [KU Leuven, Institute for Nuclear and Radiation Physics (Belgium); Fedoseev, V. [CERN, EN Department (Switzerland); Heinke, R.; Kieck, T. [University of Mainz, Institute of Physics (Germany); Marsh, B. [CERN, EN Department (Switzerland); Naubereit, P. [University of Mainz, Institute of Physics (Germany); Rothe, S.; Stora, T. [CERN, EN Department (Switzerland); Studer, D. [University of Mainz, Institute of Physics (Germany); Duppen, P. Van [KU Leuven, Institute for Nuclear and Radiation Physics (Belgium); Wendt, K. [University of Mainz, Institute of Physics (Germany)
2017-11-15
The MEDICIS-PROMED Innovative Training Network under the Horizon 2020 EU program aims to establish a network of early stage researchers, involving scientific exchange and active cooperation between leading European research institutions, universities, hospitals, and industry. Primary scientific goal is the purpose of providing and testing novel radioisotopes for nuclear medical imaging and radionuclide therapy. Within a closely linked project at CERN, a dedicated electromagnetic mass separator system is presently under installation for production of innovative radiopharmaceutical isotopes at the new CERN-MEDICIS laboratory, directly adjacent to the existing CERN-ISOLDE radioactive ion beam facility. It is planned to implement a resonance ionization laser ion source (RILIS) to ensure high efficiency and unrivaled purity in the production of radioactive ions. To provide a highly efficient ionization process, identification and characterization of a specific multi-step laser ionization scheme for each individual element with isotopes of interest is required. The element lutetium is of primary relevance, and therefore was considered as first candidate. Three two-step excitation schemes for lutetium atoms are presented in this work, and spectroscopic results are compared with data of other authors.
Laser resonance ionization spectroscopy on lutetium for the MEDICIS project
Gadelshin, V.; Cocolios, T.; Fedoseev, V.; Heinke, R.; Kieck, T.; Marsh, B.; Naubereit, P.; Rothe, S.; Stora, T.; Studer, D.; Van Duppen, P.; Wendt, K.
2017-11-01
The MEDICIS-PROMED Innovative Training Network under the Horizon 2020 EU program aims to establish a network of early stage researchers, involving scientific exchange and active cooperation between leading European research institutions, universities, hospitals, and industry. Primary scientific goal is the purpose of providing and testing novel radioisotopes for nuclear medical imaging and radionuclide therapy. Within a closely linked project at CERN, a dedicated electromagnetic mass separator system is presently under installation for production of innovative radiopharmaceutical isotopes at the new CERN-MEDICIS laboratory, directly adjacent to the existing CERN-ISOLDE radioactive ion beam facility. It is planned to implement a resonance ionization laser ion source (RILIS) to ensure high efficiency and unrivaled purity in the production of radioactive ions. To provide a highly efficient ionization process, identification and characterization of a specific multi-step laser ionization scheme for each individual element with isotopes of interest is required. The element lutetium is of primary relevance, and therefore was considered as first candidate. Three two-step excitation schemes for lutetium atoms are presented in this work, and spectroscopic results are compared with data of other authors.
Separation of thulium, ytterbium and lutetium from uranium
International Nuclear Information System (INIS)
Lopez, G.H.
1987-01-01
The behaviour at different temperatures, shaking times and hydrochloric acid concentrations on the solvent extraction system UO 2 2+ - (Tm 3+ , Yb 3+ , Lu 3+ ) - H 2 O - HCl - TBP was studied. Quantitative determinations of the elements were performed by visible spectrophotometry and X-ray fluorescence. The uranyl ion was efficiently extracted by TBP from an aqueous hydrochloric acid solution (4-7M) shaken during 10 minutes at room temperature. On these conditions the separation factors for uranium from thulium and ytterbium were found to be 3000 and from lutetium 140. (author)
International Nuclear Information System (INIS)
Koca, Atif; Ceyhan, Tanju; Erbil, Mehmet K.; Ozkaya, Ali Riza; Bekaroglu, Ozer
2007-01-01
In this study, electrochemical, electrochromic and spectroelectrochemical properties of a tert-butylcalix[4]arene bridged bis double-decker lutetium(III) phthalocyanine (Lu 2 Pc 4 2) were investigated explicitly as compared with a tert-butylcalix[4]arene bridged dimeric lutetium(III) phthalocyanine [Lu 2 Pc 2 (OAc) 2 1]. Distinctive differences between electrochemical and electrochromic properties of 1 and 2 were detected. Moreover, the properties of 1 and 2 were compared with previously reported S 4 (CH 2 ) 4 bridged Lu 2 Pc 2 (OAc) 2 and Lu 2 Pc 4 . The calixarene bridged phthalocyanine (Pc) compounds, 1 and 2 showed well-defined electrochromic behaviour with green-blue and blue-purple colour transitions. The enhanced electrochromic properties of 2, as compared to 1, were attributed to its double-decker structure, probably allowing the formation of suitable ion channels for the counter ion movement in the solid film
Independent fissile inventory verification in a large tank employing lutetium double spikes
International Nuclear Information System (INIS)
Carter, J.A.; Walker, R.L.; May, M.P.; Smith, D.H.; Hebble, T.L.
1987-01-01
A 3000-liter feed adjustment tank containing over 2400 L of uranium solution was assayed for its contents using the double spiking technique of isotope dilution mass spectrometry. Lutetium was the double spike, with the natural element used as the initial spike and enriched 176-Lu as the second. The ability of a remote sampling system was evaluated for its ability to introduce the lutetium and also to produce homogeneous sample solutions. The system was found to be satisfactory. Volumes of the tank can be measured to a precision of about 0.2%. The concentration of uranium was measured as 154.5 g/L uranium, thus giving a total of 382.3 kg in the tank as compared to the plant's best estimate of 383 kg. Uranium measurements were subjected to internal calibration calculations, with 233-U and 236-U being used as the reference isotopes. A diversion of 5% of the tank contents was simulated to evaluate the method's sensitivity in this regard. The ability of this method to give timely results of good precision makes it a strong candidate for use in material balance and inventory accountability applications; it also has potential use in quality assurance areas
DOTA-TATE peptides labelling with Lutetium 177: Preliminary study
International Nuclear Information System (INIS)
Aliaga, Eleazar; Robles, Anita; Ramos, Bertha; Martinez, Flor
2014-01-01
he peptide DOTA-TATE was labeled with lutetium 177 according to the methodology provided under the regional project RLA/6/074, sponsored by the IAEA. The labeling was done in 0.26 M gentisic acid solution in 0.8 M sodium acetate buffer, pH 5, at 100 °C for 30 minutes in a dry heating block. The radiochemical purity was assessed by thin layer chromatography, using ITLC SG strips and a mixture of 0.15 M ammonium acetate - methanol (1:1) as solvent. The radiolabeled peptide 177 Lu-DOTA-TATE reached a radiochemical purity of 98 % with a specific activity of 2,8 mCi/µg of peptide. (authors).
Energy Technology Data Exchange (ETDEWEB)
Koca, Atif [Chemical Engineering Department, Engineering Faculty, Marmara University, TR34722 Goeztepe, Istanbul (Turkey); Ceyhan, Tanju; Erbil, Mehmet K. [Department of Biochemistry, Division of Organic Chemistry, Guelhane Medical Academy (GATA), Ankara (Turkey); Ozkaya, Ali Riza [Department of Chemistry, Marmara University, TR34722 Goeztepe, Istanbul (Turkey)], E-mail: aliozkaya@marmara.edu.tr; Bekaroglu, Ozer [Department of Chemistry, Technical University of Istanbul, TR34469 Maslak, Istanbul (Turkey)], E-mail: obek@itu.edu.tr
2007-11-09
In this study, electrochemical, electrochromic and spectroelectrochemical properties of a tert-butylcalix[4]arene bridged bis double-decker lutetium(III) phthalocyanine (Lu{sub 2}Pc{sub 4}2) were investigated explicitly as compared with a tert-butylcalix[4]arene bridged dimeric lutetium(III) phthalocyanine [Lu{sub 2}Pc{sub 2}(OAc){sub 2}1]. Distinctive differences between electrochemical and electrochromic properties of 1 and 2 were detected. Moreover, the properties of 1 and 2 were compared with previously reported S{sub 4}(CH{sub 2}){sub 4} bridged Lu{sub 2}Pc{sub 2}(OAc){sub 2} and Lu{sub 2}Pc{sub 4}. The calixarene bridged phthalocyanine (Pc) compounds, 1 and 2 showed well-defined electrochromic behaviour with green-blue and blue-purple colour transitions. The enhanced electrochromic properties of 2, as compared to 1, were attributed to its double-decker structure, probably allowing the formation of suitable ion channels for the counter ion movement in the solid film.
Effect of pressure on the bandstructure and superconductivity in lutetium
International Nuclear Information System (INIS)
Asokamani, R.; Natarajan, S.; Rajagopalan, M.; Sundararajan, V.; Suvasini, M.B.; Iyakutti, K.
1984-08-01
The detailed bandstructure and superconducting behaviour of lutetium at 230 kbar pressure is reported here. The electronic contribution eta to the electron-phonon mass enhancement lambda is studied within the rigid muffin-tin (RMT) approximation. The pd and df matrix elements are expressed in terms of 'd' bandwidth, Fermi energy and muffin-tin zero. The variations of Grueneisen parameter and Debye temperature with pressure are studied and applied in the calculation of Tsub(c). The calculated Tsub(c) value agrees fairly well with the experimental value. The changes in the conduction bandwidth and the electronic specific heat coefficient with pressure are found to be in agreement with theoretical prediction. (author)
International Nuclear Information System (INIS)
Jimenez R, M.; Solache R, M.J.; Ramirez G, J.J.; Rojas H, A.
1997-01-01
With the purpose to complete information about the lutetium (III) hydrolysis constants here is used the potentiometric method to determine those in the middle of ion force 1M sodium chloride at 303 K. (Author)
Cerium-doped single crystal and transparent ceramic lutetium aluminum garnet scintillators
International Nuclear Information System (INIS)
Cherepy, Nerine J.; Kuntz, Joshua D.; Tillotson, Thomas M.; Speaks, Derrick T.; Payne, Stephen A.; Chai, B.H.T.; Porter-Chapman, Yetta; Derenzo, Stephen E.
2007-01-01
For rapid, unambiguous isotope identification, scintillator detectors providing high-resolution gamma ray spectra are required. We have fabricated Lutetium Aluminum Garnet (LuAG) using transparent ceramic processing, and report a 2-mm thick ceramic exhibiting 75% transmission and light yield comparable to single-crystal LuAG:Ce. The LuAG:Ce luminescence peaks at 550 nm, providing an excellent match for Silicon Photodiode readout. LuAG is dense (6.67 g/cm 3 ) and impervious to water, exhibits good proportionality and a fast decay (∼40 ns), and we measure light yields in excess of 20,000 photons/MeV
X-ray fluorescence analysis of lutetium oxide/oxalate for rare earth impurities
International Nuclear Information System (INIS)
Chandola, L.C.; Khanna, P.P.
1985-01-01
An X-ray fluorescence spectrometric method for the analysis of lutetium oxide is described. The sample in the oxalate form is mixed with boric acid binding material and pressed into a pellet over supporting pellet of boric acid. A Philips PW 1220 wavelength dispersive semiautomatic X-ray fluorescence spectrometer is used for the analysis. The minimum determination limit is 0.002 percent for Y, Er and Yb and 0.005 percent for Tm. Calculations for theoretical minimum detection limits and percent standard deviations at each concentration of the standard are carried out. (author)
Hyperfine interactions in 111Cd-doped lutetium sesquioxide
International Nuclear Information System (INIS)
Errico, L.A.; Renteria, M.; Bibiloni, A.G.; Requejo, F.G.
1999-01-01
We report here first Perturbed Angular Correlation (PAC) results of the electric field gradient (EFG) characterisation at 111 Cd impurities located at both non-equivalent cation sites of the bixbyite structure of Lutetium sesquioxide, between room temperature (RT) and 1273 K. The comparison with results coming from a systematic 111 Cd PAC study in bixbyites and with point-charge model (PCM) predictions shows the presence of a trapped defect at RT in the neighbourhood of the asymmetric cation site, which is completely removed at T > 623 K. The anomalous EFG temperature dependence in Lu 2 O 3 can be described in the frame of a 'two-state' model with fluctuating interactions, which enables the experimental determination of the acceptor energy level introduced by the Cd impurity in the band-gap of the semiconductor and the estimation of the oxygen vacancy density in the sample
Study of lutetium nitrate reaction with orthophosphates of alkali metals and ammonium
International Nuclear Information System (INIS)
Davitashvili, E.G.; Dzhabishvili, N.A.; Orlovskij, V.P.; Kargareteli, L.N.
1986-01-01
The process of lutetium phosphate precipitation in systems Lu(NO 3 ) 3 - M 3 PO 4 -H 2 O, where M=K + , Na, NH 4 , at 25 deg was studied. Compounds LuPO 4 x2H 2 O, 5LuPO 4 xNa 3 PO 4 x16H 2 O, 2LuPO 4 xK 3 PO 4 x6H 2 O and 2LuPO 4 (NH 4 ) 3 PO 4 x6H 2 O were isolated. The compounds prepared are roentgenoamorphous. Results of thermal decomposition of the compounds are presented
Optical emission spectrographic analysis of lutetium oxide for rare earth impurities
International Nuclear Information System (INIS)
Chandola, L.C.; Dixit, V.S.
1986-01-01
An optical emission spectrographic (OES) method has been developed for the analysis of high purity lutetium oxide to determine rare earths Er, Tm, Yb and Y. The spectra are excited by a d.c. arc run at 10 A current after mixing the sample with graphite buffer in the weight ratio 1:1. A 1200 grooves/mm grating blazed at 3300 A is used for dispersion and a Kodak SA-1 plate for recording the spectrum. The detection limit is 0.001 per cent for Tm, Yb and Y while it is 0.005 per cent for Er. The relative standard deviation of the method is ± 13.4 per cent. (author)
International Nuclear Information System (INIS)
Warmińska, Dorota; Fuchs, Anna; Lundberg, Daniel
2013-01-01
Highlights: ► In DMF the sequence values of both volumes and compressibilities of Ln 3+ ions are: La 3+ ≈ Gd 3+ > Lu 3+ . ► In DMA the ionic volumes of lanthanoid(III) metal ions are, within error limits, identical. ► Obtained results are the consequence of an ion–solvent bonding nature. -- Abstract: The concentration and temperature dependencies of density of lanthanum, gadolinium, lutetium and sodium trifluoromethanesulfonates in N,N-dimethylformamide (DMF) and N,N-dimethylacetamide (DMA) have been determined. From density data the apparent molar volumes and partial molar volumes of the salts at infinite dilution as well as the expansibilities have been evaluated. The apparent molar isentropic compressibilities of lanthanum, gadolinium, lutetium and sodium trifluoromethanesulfonates in DMF and DMA have been calculated from sound velocity data obtained at 298.15 K. The results have been discussed in terms of ion–solvent interactions
Hyperfine interactions in {sup 111}Cd-doped lutetium sesquioxide
Energy Technology Data Exchange (ETDEWEB)
Errico, L.A.; Renteria, M.; Bibiloni, A.G.; Requejo, F.G. [Universidad Nacional de La Plata, Programa TENAES (CONICET), Departamento de Fisica, Facultad de Ciencias Exactas (Argentina)
1999-09-15
We report here first Perturbed Angular Correlation (PAC) results of the electric field gradient (EFG) characterisation at {sup 111}Cd impurities located at both non-equivalent cation sites of the bixbyite structure of Lutetium sesquioxide, between room temperature (RT) and 1273 K. The comparison with results coming from a systematic {sup 111}Cd PAC study in bixbyites and with point-charge model (PCM) predictions shows the presence of a trapped defect at RT in the neighbourhood of the asymmetric cation site, which is completely removed at T > 623 K. The anomalous EFG temperature dependence in Lu{sub 2}O{sub 3} can be described in the frame of a 'two-state' model with fluctuating interactions, which enables the experimental determination of the acceptor energy level introduced by the Cd impurity in the band-gap of the semiconductor and the estimation of the oxygen vacancy density in the sample.
Neutron capture cross section measurements: case of lutetium isotopes
International Nuclear Information System (INIS)
Roig, O.; Meot, V.; Belier, G.
2011-01-01
The neutron radiative capture is a nuclear reaction that occurs in the presence of neutrons on all isotopes and on a wide energy range. The neutron capture range on Lutetium isotopes, presented here, illustrates the variety of measurements leading to the determination of cross sections. These measurements provide valuable fundamental data needed for the stockpile stewardship program, as well as for nuclear astrophysics and nuclear structure. Measurements, made in France or in United-States, involving complex detectors associated with very rare targets have significantly improved the international databases and validated models of nuclear reactions. We present results concerning the measurement of neutron radiative capture on Lu 173 , Lu 175 , Lu 176 and Lu 177m , the measurement of the probability of gamma emission in the substitution reaction Yb 174 (He 3 ,pγ)Lu 176 . The measurement of neutron cross sections on Lu 177m have permitted to highlight the process of super-elastic scattering
Arora, Geetanjali; Singh, Manoranjan; Jha, Pragati; Tripathy, Sarthak; Bal, Chandrasekhar; Mukherjee, Anirban; Shamim, Shamim A
2017-07-01
Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, followed by in-vitro and in-vivo characterization. Stannous chloride (SnCl2) solution and Lu were heated together, the pH was adjusted, and the particles were recovered by centrifugation. The heating time and amount of SnCl2 were varied to optimize the labeling protocol. The labeling efficiency (LE) and radiochemical purity (RCP) of the product were determined. The size and shape of the particles were determined by means of electron microscopy. In-vitro stability was tested in PBS and synovial fluid, and in-vivo stability was tested in humans. LE and RCP were greater than 95% and ∼99% (Rf=0-0.1), respectively. Aggregated colloidal particles were spherical (mean size: 241±47 nm). The product was stable in vitro for up to 7 days in PBS as well as in synovial fluid. Injection of the product into the infected knee joint of a patient resulted in its homogenous distribution in the intra-articular space, as seen on the scan. No leakage of activity was seen outside the knee joint even 7 days after injection, indicating good tracer binding and in-vivo stability. Lu-Sn colloid was successfully prepared with a high LE (>95%) and high RCP (99%) under optimized reaction conditions. Because of the numerous benefits of Lu and the ease of preparation of tin colloid particles, Lu-Sn colloid particles are significantly superior to its currently available counterparts for use in radiosynovectomy.
International Nuclear Information System (INIS)
Hu, Andrew Teh; Hu Tenyi; Liu Lungchang
2003-01-01
Both photoelectric and electrochromic effects on lutetium tetrakis(tert-butyl)bisphthalocyaninate (Lu(TBPc) 2 ) have been carried out in this study. Lu(TBPc) 2 is known for its electrochromic performance, but its photoelectric effect has not mentioned in the literature. The electrochromic properties of Lu(TBPc) 2 have been measured by cyclic voltammetry (CV) and UV-Vis spectrometer at the same time. It takes less than 1.5 s for the color to change from red to green under 0.9 V. Its cycle life is at least over 500 times. Furthermore, we also investigate its photoelectric conversion properties. Its photoelectric cell exhibits a positive photo-electricity conversion effect with a short-circuit photocurrent (46.4 μA/cm 2 ) under illumination of white light (1.201 mW/cm 2 )
Electrochromism of solid films of blue form of lutetium phthalocyanine complexe
Energy Technology Data Exchange (ETDEWEB)
Gavrilov, V I; Konstantinov, A P; Luk' yanets, E A; Shelepin, I V
1986-12-01
Results of spectral-electrochemical study on electrochromic films of blue form of tret-butyl-substituted lutetium diphthalocyanine deposited on the surface of an electrode contacting with electrolyte aqueous solution are presented. In the 0.2-1.15 V potential range sweep of the electrode potential is followed by reversible change of the film colour in the following succession: blue reversible green reversible red. Electrochromic properties of the film confirm the corresponding spectral transitions from the initial state to monoelectron-oxidized and further on to the product of two-electron oxidation. Under potential sweeping towards the anode in the 1.4 V range and irreversible wave arises; potential achievement of this wave brings about complete change in the form of j, E-curves. The consequent electrode processes are followed by change in the film colour green - red that is associated witn mechanical fracture of the film.
Labelling of the peptide Dota-Octreotate with Lutetium 177
International Nuclear Information System (INIS)
Hernandez B, C.A.
2004-01-01
In this work is described the optimization of the reaction conditions to obtain the complex 177 Lu-Dota-TATE with a radiochemical purity > 95%, even so the studies of stability In vitro to the dilution in saline solution, stability in human serum and challenge to the cystein. The biodistribution studies are presented in mice Balb-C and the tests of biological recognition using one lines cellular of pancreatic adenoma (AR42-J). The obtained results show a high stability of the radio complex in vitro, since it doesn't suffer trans chelation from the Lutetium-177 to plasmatic proteins. The biodistribution tests in mice Balb-C demonstrated an appropriate lipophilly of the complex to be excreted in more proportion by the kidneys without significant accumulation in healthy tissues. It is necessary to mention that the drop activity specifies (3.54 μg / 37 MBq) obtained in the irradiation of 176 Lu 2 O 3 it allowed to verify the union of the 177 Lu-Dota-Tate to membrane receivers but without being able to obtain the saturation curves and competition required to characterize quantitatively the biological recognition. (Author)
Energy Technology Data Exchange (ETDEWEB)
Loeser, Anastassia
2016-09-28
The {sup 177}lutetium-DOTATATE peptide radio-receptor therapy is a promising approach for the palliative treatment of patients with inoperable endocrine neoplasm. The individually variable biological dispersion and the tumor uptake including the protection of critical organs require a precise and reliable organ and tumor dosimetry. The HERMES Hybrid dosimetry module has appeared as reliable and user-friendly tool for clinical application. The next step is supposed to by the complete integration of 3D SPECT imaging.
Energy Technology Data Exchange (ETDEWEB)
Lopez-G, H.; Jimenez R, M.; Solache R, M. [ININ. Apdo. Postal 18-1027, Mexico D.F. (Mexico); Rojas H, A. [UAM-I, A.P. 55-534, 09340, Mexico. D.F. (Mexico)
2006-07-01
solubility product constants and the first of lutetium hydrolysis in the interval of initial concentration of 3.72 X 10{sup -5} to 2.09 X 10{sup -3} M of lutetium, in a 2M of NaCIO{sub 4} media, at 303 K and under conditions free of CO{sub 2} its were considered. The solubility diagrams (pLu{sub (ac)}-pC{sub H}) by means of a radiochemical method were obtained, and starting from its the pC{sub H} values that limit the saturation and no-saturation zones of the solutions were settled down. Those diagrams allowed, also, to calculate the solubility product constants of Lu(OH){sub 3}. The experimental data to the polynomial solubility equation were adjusted, what allowed to calculate those values of the solubility product constants of Lu(OH){sub 3} and to determine the first hydrolysis constant. The value of precipitation pC{sub H} diminishes when the initial concentration of the lutetium increases, while the values of K{sub ps} and {beta}{sub 1,H} its remain constant. (Author)
International Nuclear Information System (INIS)
Parra, Vicente; Bouvet, Marcel; Brunet, Jerome; Rodriguez-Mendez, Maria Luz; Saja, Jose Antonio de
2008-01-01
In this article, we present new experimental data regarding the influence of ammonia (NH 3 ) and water (from wet atmospheres) in the conducting properties of lutetium bisphthalocyanine (LuPc 2 )-based films in two very different structural features, namely Langmuir-Blodgett (LB) and vacuum evaporated (VE) films, deposited onto interdigitated electrodes. We pay particular attention to the effect of the mass flow rate ratios of the active gases, which certainly influence the mechanism of conduction of the chemiresistors. The particular trends observed are discussed on the basis of two main contributions: the electronic effects and the competition between gases in the adsorption process
Energy Technology Data Exchange (ETDEWEB)
Parra, Vicente [Ecole Superieure de Physique et Chimie Industrielles (ESPCI) and Laboratoire de Chimie Inorganique et Materiaux Moleculaires-CNRS UMR 7071, Universite Pierre et Marie Curie (Paris 6) (France); Bouvet, Marcel [Ecole Superieure de Physique et Chimie Industrielles (ESPCI) and Laboratoire de Chimie Inorganique et Materiaux Moleculaires-CNRS UMR 7071, Universite Pierre et Marie Curie (Paris 6) (France)], E-mail: marcel.bouvet@espci.fr; Brunet, Jerome [Universite Blaise Pascal, LASMEA-CNRS UMR 6602, Clermont-Ferrand (France); Rodriguez-Mendez, Maria Luz [Dept. Quimica Fisica y Quimica Inorganica, Escuela Tecnica Superior de Ingenieros Industriales (E.T.S.I.I), Universidad de Valladolid (Spain); Saja, Jose Antonio de [Dept. Fisica de la Materia Condensada, Facultad de Ciencias, Universidad de Valladolid (Spain)
2008-10-31
In this article, we present new experimental data regarding the influence of ammonia (NH{sub 3}) and water (from wet atmospheres) in the conducting properties of lutetium bisphthalocyanine (LuPc{sub 2})-based films in two very different structural features, namely Langmuir-Blodgett (LB) and vacuum evaporated (VE) films, deposited onto interdigitated electrodes. We pay particular attention to the effect of the mass flow rate ratios of the active gases, which certainly influence the mechanism of conduction of the chemiresistors. The particular trends observed are discussed on the basis of two main contributions: the electronic effects and the competition between gases in the adsorption process.
Mostapha, S; Berthon, C; Fontaine-Vive, F; Gaysinski, M; Guérin, L; Guillaumont, D; Massi, L; Monfardini, I; Solari, P L; Thomas, O P; Charbonnel, M C; Den Auwer, C
2014-02-01
Although the physiological impact of the actinide elements as nuclear toxicants has been widely investigated for half a century, a description of their interactions with biological molecules remains limited. It is however of primary importance to better assess the determinants of actinide speciation in cells and more generally in living organisms to unravel the molecular processes underlying actinide transport and deposition in tissues. The biological pathways of this family of elements in case of accidental contamination or chronic natural exposure (in the case of uranium rich soils for instance) are therefore a crucial issue of public health and of societal impact. Because of the high chemical affinity of those actinide elements for phosphate groups and the ubiquity of such chemical functions in biochemistry, phosphate derivatives are considered as probable targets of these cations. Among them, nucleotides and in particular adenosine mono- (AMP) and triphosphate (ATP) nucleotides occur in more chemical reactions than any other compounds on the earth's surface, except water, and are therefore critical target molecules. In the present study, we are interested in trans-plutonium actinide elements, in particular americium and curium that are more rarely considered in environmental and bioaccumulation studies than early actinides like uranium, neptunium and plutonium. A first step in this strategy is to work with chemical analogues like lanthanides that are not radioactive and therefore allow extended physical chemical characterization to be conducted that are difficult to perform with radioactive materials. We describe herein the interaction of lutetium(III) with adenosine AMP and ATP. With AMP and ATP, insoluble amorphous compounds have been obtained with molar ratios of 1:2 and 1:1, respectively. With an excess of ATP, with 1:2 molar ratio, a soluble complex has been obtained. A combination of spectroscopic techniques (IR, NMR, ESI-MS, EXAFS) together with quantum
Lutetium 177-Labeled Cetuximab Evaluation for Radioimmunotherapeutic Applications
Directory of Open Access Journals (Sweden)
Kamal Yavari
2012-06-01
Full Text Available Background & Objectives: The monoclonal antibody cetuximab binds to EGFR and thus provides an opportunity to create both imaging and therapeutic modalities that target this receptor. The potential of cetuximab as a radioimmunoconjugate was investigated and quality control tests (in vitro and in vivo were performed as a first step in the production of a new radiopharmaceutical. Methods : Cetuximab solution was dialyzed and concentrated using an Amicon Ultra-15 filter. Purified antibody was labeled with lutetium-177 using the acyclic bifunctional chelator, DOTA-NHS, and radioimmunoconjugates were purified by PD10 columns. Radiochemical purity and stability in buffer and human blood serum were determined using thin layer chromatography. Integrity of the radiolabeled complex was checked by SDS-PAGE. Preliminary biodistribution studies in normal mice model performed to determine radioimmunoconjugates distribution up to 72h. Results: The radiochemical purity of the complex was 98±1%. The stabilities in phosphate buffer and in human blood serum at 96 hours post-preparation were 96±2 % and 78±4%, respectively. All of the samples, controls and radiolabeled antibodies, showed a similar pattern of migration in the gel electrophoresis. Biodistribution of Lu177-cetuximab was evaluated in normal mice and the highest ID/g% was observed in the blood (13.2±1.3% at 24 hours and the liver (9.1±1.3% at 24 hours. Conclusion: Our results show that DOTA-cituximab can be labeled with 177Lu. Lu177-cetuximab has sufficient stability and retains its integrity. The new complex could be considered for further evaluation in animals and possibly in humans as a new radiopharmaceutical for use in radioimmunotherapy of cancers.
Enthalpies of mixing in binary liquid alloys of lutetium with 3d metals
Energy Technology Data Exchange (ETDEWEB)
Ivanov, Michael; Berezutski, Vadim [National Academy of Sciences, Kyiv (Ukraine). I. Frantsevich Institute for Problems of Materials Science; Usenko, Natalia; Kotova, Natalia [Taras Shevchenko National Univ., Kyiv (Ukraine). Dept. of Chemistry
2017-01-15
The enthalpies of mixing in binary liquid alloys of lutetium with chromium, cobalt, nickel and copper were determined at 1 773 - 1 947 K by isoperibolic calorimetry. The enthalpies of mixing in the Lu-Cr melts (measured up to 40 at.% Cr) demonstrate endothermic effects (ΔH = 6.88 ± 0.66 kJ . mol{sup -1} at x{sub Lu} = 0.60), whereas significant exothermic enthalpies of mixing have been established within a wide composition region for the Co-Lu, Ni-Lu and Cu-Lu liquid alloys. Minimum values of the integral enthalpy of mixing are as follows: ΔH{sub min} = -23.57 ± 1.41 kJ . mol{sup -1} at x{sub Lu} = 0.38 for the Co-Lu system; ΔH{sub min} = -48.65 ± 2.83 kJ . mol{sup -1} at x{sub Lu} = 0.40 for the Ni-Lu system; ΔH{sub min} = -24.63 ± 1.52 kJ . mol{sup -1} at x{sub Lu} = 0.37 for the Cu-Lu system.
International Nuclear Information System (INIS)
Silva, Giovana Pasqualini da
2008-01-01
The - emitter 177 Lu is a promising therapeutic radioisotope for the curative treatment of cancer using labelled proteins. It has a half - life of 6.71 day and maximum and average (3 energies of 421 and 133 keV, respectively, resulting in a short range of irradiation of tissue. The decay is accompanied by the emission of low energy -radiation of 208.3 keV (11%) and 113 keV (6.4%), suitable for simultaneous imaging. Lu can be produced by two different routes, namely, by irradiation of natural Lu 2 O 3 target ( 176 Lu, 2.6%) or enriched (in 176 Lu) Lu 2 O 3 target, and also by irradiation of Yb target (Yb 2 O 3 ) followed by radiochemical separation of Lu from Yb isotopes. The objective of this work is the development of a method of the production of 177 Lu through of the (n, gamma) nuclear reaction, by the direct and indirect method of production. Targets of lutetium oxide and ytterbium oxide were irradiated for evaluation of the activity produced and the chemical separation of lutetium and ytterbium was studied using different ion exchange resins. For the direct method, the best results were obtained using the target Lu 2 O 3 enriched in 39.6%. The best results for the indirect method were achieved with the process of separation using 0.25M - HlBA as eluent. The results showed that it is possible to produce 177 Lu of low specific activity for labeling molecules used for bone pain relief and in radiosynoviortesy. (author)
Optical Fibre NO2 Sensor Based on Lutetium Bisphthalocyanine in a Mesoporous Silica Matrix
Directory of Open Access Journals (Sweden)
Marc Debliquy
2018-03-01
Full Text Available In this article, we describe a NO2 sensor consisting of a coating based on lutetium bisphthalocyanine (LuPc2 in mesoporous silica. The sensor exploits the absorption spectrum change of this material which strongly and reversibly decreases in contact with NO2. NO2 is measured by following the amplitude change in the reflected spectrum of the coating deposited on the tip of a silica fibre. As diffusion of NO2 in LuPc2 is slow, the response time could be slow. To reduce it, the active molecules are dispersed in a mesoporous silica matrix deposited by a sol-gel process (Evaporation Induced Self Assembly avoiding the formation of large crystals. Doing so, the response is fairly fast. As the recovery is slow at room temperature, the recovery time is reduced by exposure to UV light at 365 nm. This UV light is directly introduced in the fibre yielding a practical sensor sensitive to NO2 in the ppm range suitable for pollution monitoring.
International Nuclear Information System (INIS)
Noro, Junji; Sekine, Tatsuya.
1992-01-01
The solvent extraction of lanthanum(III), europium(III), lutetium(III), scandium(III), and indium(III) in 0.1 mol dm -3 sodium nitrate solutions with 2-thenoyltrifluoroacetone (Htta) in the absence and presence of tetrabutylammonium ions (tba + ) into carbon tetrachloride was measured. The extraction of lanthanum(III), europium(III), and lutetium(III) was greatly enhanced by the addition of tba + ; this could be explained in terms of the extraction of a ternary complex, M(tta) 4 - tba + . However, the extractions of scandium(III) and indium(III) were nearly the same when tba + was added. The data were treated on the basis of the formation equilibrium of the ternary complex from the neutral chelate, M(tta) 3 , with the extracted ion-pairs of the reagents, tta - tba + , in the organic phase. It was concluded that the degree of association of M(tta) 3 with the ion-pair, tta - tba + , is greater in the order La(tta) 3 ≅ Eu(tta) 3 > Lu(tta) 3 , or that the stability of the ternary complex in the organic phase is higher in the order La(tta) 4 - tba + ≅ Eu(tta) 4 - tba + > Lu(tta) 4 - tba + . This is similar to those of adduct metal chelates of Htta with tributylphosphate (TBP) in synergistic extraction systems. (author)
Photodynamic therapy with motexafin lutetium for rectal cancer: a preclinical model in the dog.
Ross, H M; Smelstoys, J A; Davis, G J; Kapatkin, A S; Del Piero, F; Reineke, E; Wang, H; Zhu, T C; Busch, T M; Yodh, A G; Hahn, S M
2006-10-01
Local recurrence of rectal cancer remains a significant clinical problem despite multi-modality therapy. Photodynamic Therapy (PDT) is a cancer treatment which generates tumor kill through the production of singlet oxygen in cells containing a photosensitizing drug when exposed to laser light of a specific wavelength. PDT is a promising modality for prevention of local recurrence of rectal cancer for several reasons: tumor cells may selectively retain photosensitizer at higher levels than normal tissues, the pelvis after mesorectal excision is a fixed space amenable to intra-operative illumination, and PDT can generate toxicity in tissues up to 1 cm thick. This study evaluated the safety, tissue penetration of 730 nm light, normal tissue toxicity and surgical outcome in a dog model of rectal resection after motexafin lutetium-mediated photodynamic therapy. Ten mixed breed dogs were used. Eight dogs underwent proctectomy and low rectal end to end stapled anastomosis. Six dogs received the photosensitizing agent motexafin lutetium (MLu, Pharmacyclics, Inc., Sunnyvale, CA) of 2 mg/kg preoperatively and underwent subsequent pelvic illumination of the transected distal rectum of 730 nm light with light doses ranging from 0.5 J/cm(2) to 10 J/cm(2) three hours after drug delivery. Two dogs received light, but no drug, and underwent proctectomy and low-rectal stapled anastomosis. Two dogs underwent midline laparotomy and pelvic illumination. Light penetration in tissues was determined for small bowel, rectum, pelvic sidewall, and skin. Clinical outcomes were recorded. Animals were sacrificed at 14 days and histological evaluation was performed. All dogs recovered uneventfully. No dog suffered an anastomotic leak. Severe tissue toxicity was not seen. Histological findings at necropsy revealed mild enteritis in all dogs. The excitation light penetration depths were 0.46 +/- 0.18, 0.46 +/- 0.15, and 0.69 +/- 0.39 cm, respectively, for rectum, small bowel, and peritoneum in
Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System.
Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J
2015-01-01
Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 ((90)Y) and lutetium-177 ((177)Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. All syntheses were carried out using the Eckert & Ziegler Eurotope's Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) (177)Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. A total of 17 [(177)Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [(177)Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. The automated synthesis of [(177)Lu]-DOTATATE using Eckert & Ziegler Eurotope's Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA (177)Lu and almost negligible radiation exposure of the operators.
Displaying of formation of atomic clusters in radioactive lutetium oxide films
International Nuclear Information System (INIS)
Kartashov, V.M.; Troitskata, A.G.
2002-01-01
We earlier reported the results of our investigations of electron spectra of radioactive lutetium oxide films on the magnetic β-spectrometer π√2 with momentum resolution 0.04-0.1 %. The researches were conducted many times during ≅15 years, and a lot of the data has resulted us in the conclusion about possible formation of toroidal structures in these films. It is impossible to consider a radioactive oxide layer, deposited on metallic foil support having the electric potential of its foil support on all its depth because of its high dielectric properties. There is the potential gradient (≅10 6 -10 7 V/c) on its depth because of constant outflow of electrons from its surface. Our experiments included in itself also giving a potential, accelerating for electrons, to the metallic foil support. In this case we received a capability to watch the segments of auto emission and low energy Auger electrons. The analysis of the threshold relations and behavior (in time) of the M 4 NN and M 5 NN Auger electron intensities have resulted us in the conclusion that the greatest contribution to structure formations of these oxide films is introduced by electrons of M 4 -, M 5 - and N-sub-shell of ytterbium atoms (being formed as the result of radioactive decay of the lutetium fraction with half-times from 140 to 1200 days). The auto emission electron spectrum testifies to composite scission of M4 and M5 stationary states of the atom. It is possible to offer as the explanation a quantum flat rotator. If the particle orbit un-compresses the solenoid with a magnetic flux Φ, power condition of a rotator E m =h 2 (m-Φ/Φ 0 ) 2 /(8πm e R 0 2 ), where m e - electron mass, R 0 - an electron orbit radius; m - a magnetic quantum number, a Φ 0 =h c/e - a quantum of magnetic flux. At a quantum flow Φ=nΦ 0 (n - integer) and the power spectrum does not differ from a spectrum without the solenoid. The behavior (in time) of the experimental auto emission electron spectrum responds
2010-07-01
... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Evaluation. 150.4 Section 150...(a)(2) § 150.4 Evaluation. (a) Upon submission of a request by a foreign government for the issuance... Director to initiate independently an evaluation pursuant to § 150.2(a) of this part, a notice will be...
Energy Technology Data Exchange (ETDEWEB)
Hernandez B, C.A
2004-07-01
In this work is described the optimization of the reaction conditions to obtain the complex {sup 177} Lu-Dota-TATE with a radiochemical purity > 95%, even so the studies of stability In vitro to the dilution in saline solution, stability in human serum and challenge to the cystein. The biodistribution studies are presented in mice Balb-C and the tests of biological recognition using one lines cellular of pancreatic adenoma (AR42-J). The obtained results show a high stability of the radio complex in vitro, since it doesn't suffer trans chelation from the Lutetium-177 to plasmatic proteins. The biodistribution tests in mice Balb-C demonstrated an appropriate lipophilly of the complex to be excreted in more proportion by the kidneys without significant accumulation in healthy tissues. It is necessary to mention that the drop activity specifies (3.54 {mu}g / 37 MBq) obtained in the irradiation of {sup 176} Lu{sub 2}O{sub 3} it allowed to verify the union of the {sup 177}Lu-Dota-Tate to membrane receivers but without being able to obtain the saturation curves and competition required to characterize quantitatively the biological recognition. (Author)
2010-01-01
..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.150 Goat. Goat means meat produced from goats. ... 7 Agriculture 3 2010-01-01 2010-01-01 false Goat. 65.150 Section 65.150 Agriculture Regulations of...
2010-01-01
... 7 Agriculture 3 2010-01-01 2010-01-01 false Containers. 58.150 Section 58.150 Agriculture... Identification § 58.150 Containers. (a) The size, style, and type of packaging used for dairy products shall be commercially acceptable containers and packaging materials which will satisfactorily cover and protect the...
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Settlement. 150.413 Section 150.413 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.413 Settlement. CMS has exclusive...
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 60.150 Section 60.150 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Quality Assurance § 60.150 Scope. As used in this part, quality assurance comprises all those planned and systematic...
β- decay of 150Ce to odd-odd 150Pr
International Nuclear Information System (INIS)
Kojima, Yasuaki; Shibata, Michihiro; Kosuga, Kazuto; Shima, Yosuke; Taniguchi, Akihiro; Hayashi, Hiroaki
2015-01-01
The β - decay of 150 Ce having a half-life of 6.05(7) s produced by the thermal-neutron-induced fission of 235 U has been studied using the on-line isotope separator at the Kyoto University Research Reactor. A decay scheme containing 18 excited levels and 55 γ-rays was constructed from γ-ray singles and γ-γ coincidence measurements. Of these, 9 levels and 37 γ-rays were newly placed. The dominant β-feeding observed at the 110 keV level of 150 Pr was found to be an allowed unhindered spin-flip transition. On the basis of the systematics of the neighboring nuclides, the Gallagher-Moszkowski coupling rules, and the selection rules for the β-decay of deformed nuclei, the Nilsson configurations of the ground and 110 keV states in 150 Pr were newly proposed to be π5/2 + [413]-ν3/2 - [521] and π5/2 - [532]-ν3/2 - [532], respectively. (author)
2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Reports. 812.150 Section 812.150 Food and Drugs... INVESTIGATIONAL DEVICE EXEMPTIONS Records and Reports § 812.150 Reports. (a) Investigator reports. An investigator shall prepare and submit the following complete, accurate, and timely reports: (1) Unanticipated adverse...
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...
Energy Technology Data Exchange (ETDEWEB)
Hu Shanshan [School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Yang Jun, E-mail: jyang@swu.edu.cn [School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Li Chunxia [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Lin Jun, E-mail: jlin@ciac.jl.cn [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
2012-04-16
Highlights: Black-Right-Pointing-Pointer Uniform and dispersive cubic precursor can be synthesized by sample hydrothermal process. Black-Right-Pointing-Pointer Hydrothermal precursor could transform to Lu{sub 2}O{sub 3}:RE{sup 3+} with its original cubic morphology. Black-Right-Pointing-Pointer Nearly equal intensities of blue, green, and red emissions under single 980 nm laser. Black-Right-Pointing-Pointer Lu{sub 2}O{sub 3}:RE{sup 3+} show bright white light emission, clearly visible to the naked eyes. Black-Right-Pointing-Pointer Chromaticity coordinate is very close to the standard equal energy white light illuminate. - Abstract: Uniform and dispersive Lu{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+}/Tm{sup 3+} nanocubes have been successfully synthesized by hydrothermal process with subsequent calcination at 900 Degree-Sign C. The as-formed RE{sup 3+}-doped lutetium oxide precursor via the hydrothermal process, as a template, could transform to RE{sup 3+}-doped Lu{sub 2}O{sub 3} with their original cubic morphology and slight shrinkage in the size after post-annealing process. The formation mechanism for the lutetium oxide precursor cubes has been proposed. Under single wavelength diode laser excitation of 980 nm, the as-obtained Lu{sub 2}O{sub 3}:3%Yb{sup 3+}/0.5%Er{sup 3+}/0.3%Tm{sup 3+} nanocubes show nearly equal intensities of blue (Tm{sup 3+}: {sup 1}G{sub 4} {yields} {sup 3}H{sub 6}), green (Er{sup 3+}: ({sup 2}H{sub 11/2}, {sup 4}S{sub 3/2}) {yields} {sup 4}I{sub 15/2}), and red (Er{sup 3+}: {sup 4}F{sub 9/2} {yields} {sup 4}I{sub 15/2}) emissions, which produces bright white light emission, clearly visible to the naked eyes. The main pathways to populate the upper emitting states come from the energy-transfer processes from Yb{sup 3+} to Tm{sup 3+}/Er{sup 3+}, respectively. The chromaticity coordinate of the Lu{sub 2}O{sub 3}:3%Yb{sup 3+}/0.5%Er{sup 3+}/0.3%Tm{sup 3+} sample is calculated to be about x = 0.3403 and y = 0.3169, which falls exactly within the
Spectroscopic studies of lutetium pyro-silicates Lu2Si2O7 doped with bismuth and europium
International Nuclear Information System (INIS)
Bretheau-Raynal, Francoise
1981-01-01
Single crystals of thortveitite structure pyro-silicates were grown by a floating zone technique associated with an arc image furnace. The samples were systematically characterized by X-Ray diffraction and microprobe analysis. Thanks to oriented single crystals of Lu 2 Si 2 O 7 , Yb 2 Si 2 O 7 and Sc 2 Si 2 O 7 , the recorded infrared and Raman spectra allow complete attribution of internal and external vibration modes, in good agreement with group theory predictions for C 2h factor group. Spectroscopic studies of Eu 3+ doping ion in Lu 2 Si 2 O 7 confirm C 2 point symmetry for the cationic site. Oscillator strengths and Judd-Ofelt parameters for Eu 3+ were calculated. A three level scheme ( 1 S 0 , 3 P 0 , 3 P 1 ) of Bi 3+ ion is used to explain radiative and non radiative mechanisms in Lu 2 Si 2 O 7 doped with bismuth. Finally, the mechanisms of low temperature (T =9 K) energy transfer between Bi 3+ and Eu 3+ in lutetium pyro-silicate was studied. The transfer occurs by non radiative process, without any diffusion of the excitation energy within the donor system and is due to dipole-dipole interactions between Bi 3+ and Eu 3+ ions. (author) [fr
7 CFR 1726.150 - Headquarters buildings.
2010-01-01
... 7 Agriculture 11 2010-01-01 2010-01-01 false Headquarters buildings. 1726.150 Section 1726.150... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings. This section includes headquarters buildings such as warehouses and equipment service type buildings...
21 CFR 211.150 - Distribution procedures.
2010-04-01
...: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Holding and Distribution § 211.150 Distribution procedures. Written procedures shall be established, and followed, describing the... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Distribution procedures. 211.150 Section 211.150...
45 CFR 150.217 - Preliminary determination.
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Preliminary determination. 150.217 Section 150.217... Are Failing To Substantially Enforce HIPAA Requirements § 150.217 Preliminary determination. If, at... designees). (b) Notifies the State of CMS's preliminary determination that the State has failed to...
45 CFR 150.219 - Final determination.
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Final determination. 150.219 Section 150.219... Are Failing To Substantially Enforce HIPAA Requirements § 150.219 Final determination. If, after... the State a written notice of its final determination. The notice includes the following: (a...
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Citation. 105-1.150 Section 105-1.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.150 Citation. (a...
29 CFR 1926.150 - Fire protection.
2010-07-01
... 29 Labor 8 2010-07-01 2010-07-01 false Fire protection. 1926.150 Section 1926.150 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Fire Protection and Prevention § 1926.150 Fire protection. (a) General requirements. (1) The employer shall be responsible for the development of a fire...
2010-10-01
... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.150 Section 423.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Cost Control and Quality Improvement Requirements...
26 CFR 1.50B-4 - Partnerships.
2010-04-01
... § 1.50A-3, or if the partnership fails to pay comparable wages and such failure is subject to the... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Partnerships. 1.50B-4 Section 1.50B-4 Internal... Credit for Expenses of Work Incentive Programs § 1.50B-4 Partnerships. (a) General rule—(1) In general...
International Nuclear Information System (INIS)
Knapp, F.F. Jr.
2009-01-01
Lutetium-177 (Lu-177) is of broad interest for therapeutic applications where the deposition of localized radiation can benefit from the limited soft tissue penetration of the 0.497 MeV beta particle (max. = 2.76 mm). Examples of Lu-177 therapeutic strategies include treatment of small SS2/SS5-expressing tumors with targeted peptides and radiosynovectomy. Emission of a 208 keV gamma photon (11 %) allows imaging for evaluation of localization and biokinetics, and for targeting applications, correlation of uptake with therapeutic response. A broad spectrum of research reactors with even modest thermal neutron flux (e.g. > 1 x 10 14 ) can produce carrier-added Lu-177 with sufficient specific activity (SA) > 10 Ci/mg Lu by the 'direct' approach by irradiation of Lu-176. For low SA applications, thermal flux of > 10 13 in low-medium flux reactors provides sufficient SA (> 0.5 mCi Lu-177/mg) for preparation of Lu-EDTMP for synovectomy. Although relative Lu-177m/Lu-177 activity levels from 'direct' production can be very low (> 10 -5 ), the Lu-177m impurity levels can present an issue with radioactive waste storage requirements at some institutions. The alternative 'indirect' approach using decay of reactor produced ytterbium-177 available from by neutron irradiation of enriched Yb-176 targets provides no-carrier-added (nca) Lu-177 (theoretical SA = 109 Ci/mg Lu). Purification of the microscopic levels of nca Lu-177 from macroscopic Yb levels at the high multi Curie production level is a more challenging approach, since production yields are relatively low even at high thermal flux (e.g. 2 x 10 15 neutrons/cm 2 /sec). In addition, high mass Lu/Yb separation is especially time consuming, can generate significant waste, and the relatively expensive Yb-176 target material (> 97%, ∼ $ 20/mg) must be recovered, re-purified and used for subsequent target preparation. However, a number of effective methods for the Lu/Yb separation and Yb recovery have been reported, and even
2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Storage. 820.150 Section 820.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES... product to prevent mixups, damage, deterioration, contamination, or other adverse effects pending use or...
2010-07-01
... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The...
Weasel works SA-150: Design study of a 100 to 150 passenger transport aircraft
Alkema, Kevin; Comeaux, Michael; Gilbert, Timothy; Para, Victor; Toepfer, George
1993-01-01
As the year 2000 rapidly approaches, the airlines are faced with an extremely competitive and environmentally restrictive marketplace. In order to survive, commercial air carriers will need to find new ways to lower their direct operating costs, increase load factors and comply with tightening federal and international constraints. The SA-150 has been designed to meet these demands by focusing on the areas of aerodynamic efficiency, an improved level of passenger comfort, and a limited application of advanced technology. The SA-150 has been optimized for a 500 nmi. mission to help the airlines meet the challenges of the short haul, quick turnaround flight. With a maximum capacity of 124 passengers, and full baggage, the SA-150 is also capable of covering a range of 1500 nmi. This additional range capability will provide the airlines with flexibility when scheduling their routes. The aircraft features a 'V' tail, fly-by-wire system and is powered by two turbofans mounted under a twelve aspect ratio wing. The SA-150 will have an initial production run of 800 units and have a purchase price of $37.7 million in 1993 dollars.
32 CFR 150.6 - Signing of papers.
2010-07-01
... 32 National Defense 1 2010-07-01 2010-07-01 false Signing of papers. 150.6 Section 150.6 National... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.6 Signing of papers. All formal papers shall be signed and shall show, typewritten or printed, the signer's name, address, military grade...
21 CFR 160.150 - Frozen egg whites.
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen egg whites. 160.150 Section 160.150 Food... HUMAN CONSUMPTION EGGS AND EGG PRODUCTS Requirements for Specific Standardized Eggs and Egg Products § 160.150 Frozen egg whites. (a) Frozen egg whites, frozen egg albumen is the food prepared by freezing...
Energy Technology Data Exchange (ETDEWEB)
Roig, O.; Meot, V.; Belier, G. [CEA Bruyeres-le-Chatel, 91 (France)
2011-07-15
The neutron radiative capture is a nuclear reaction that occurs in the presence of neutrons on all isotopes and on a wide energy range. The neutron capture range on Lutetium isotopes, presented here, illustrates the variety of measurements leading to the determination of cross sections. These measurements provide valuable fundamental data needed for the stockpile stewardship program, as well as for nuclear astrophysics and nuclear structure. Measurements, made in France or in United-States, involving complex detectors associated with very rare targets have significantly improved the international databases and validated models of nuclear reactions. We present results concerning the measurement of neutron radiative capture on Lu{sup 173}, Lu{sup 175}, Lu{sup 176} and Lu{sup 177m}, the measurement of the probability of gamma emission in the substitution reaction Yb{sup 174}(He{sup 3},p{gamma})Lu{sup 176}. The measurement of neutron cross sections on Lu{sup 177m} have permitted to highlight the process of super-elastic scattering
Two-neutrino double-β decay of 150Nd to excited final states in 150Sm
Kidd, M. F.; Esterline, J. H.; Finch, S. W.; Tornow, W.
2014-11-01
Background: Double-β decay is a rare nuclear process in which two neutrons in the nucleus are converted to two protons with the emission of two electrons and two electron antineutrinos. Purpose: We measured the half-life of the two-neutrino double-β decay of 150Nd to excited final states of 150Sm by detecting the deexcitation γ rays of the daughter nucleus. Method: This study yields the first detection of the coincidence γ rays from the 0 1+ excited state of 150Sm. These γ rays have energies of 333.97 and 406.52 keV and are emitted in coincidence through a 01+→21+→0gs+ transition. Results: The enriched Nd2O3 sample consisted of 40.13 g 150Nd and was observed for 642.8 days at the Kimballton Underground Research Facility, producing 21.6 net events in the region of interest. This count rate gives a half-life of T1 /2=[1 .07-0.25+0.45(stat ) ±0.07 (syst ) ] ×1020 yr. The effective nuclear matrix element was found to be 0.0465 -0.0054+0.0098. Finally, lower limits were obtained for decays to higher excited final states. Conclusions: Our half-life measurement agrees within uncertainties with another recent measurement in which no coincidence was employed. Our nuclear matrix element calculation may have an impact on a recent neutrinoless double-β decay nuclear matrix element calculation which implies that the decay to the first excited state in 150Sm is favored over that to the ground state.
44 CFR 150.3 - Nomination process.
2010-10-01
... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Nomination process. 150.3 Section 150.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Nomination process. (a) The Nominating Officials nominating Firefighters and Civil Defense Officers shall...
40 CFR 1065.150 - Continuous sampling.
2010-07-01
... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Continuous sampling. 1065.150 Section... ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous sampling techniques for measurements that involve raw or dilute sampling. Make sure continuous sampling...
44 CFR 150.7 - Selection process.
2010-10-01
... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Selection process. 150.7 Section 150.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Selection process. (a) President's Award. Nominations for the President's Award shall be reviewed, and...
B 150 civil engineering futures
DEFF Research Database (Denmark)
Foreword B150 –Civil Engineering Futures consists of interviews made, articles written, and projects presented in connection with the 150th anniversary celebrations of the study of civil engineering in Denmark. Instead of a historical retrospect, it was decided to look into the future. What...... challenges will the next 150 years bring civil engineers? Researchers and lecturers at DTU’s Department of Civil Engineering (known as DTU Byg) suggested possible events, and we also consulted civil engineers and their business partners in the building industry. In this way, a programme was put together...... theme in twentieth century architecture. Together, civil engineer Peter Rice and architect Ian Ritchie created a paradigm shift with their revolutionary ideas for glass facades supported by cables. Glued and bolted constructions made entirely of glass are now a reality in small-scale projects, yet...
38 CFR 17.150 - Prosthetic and similar appliances.
2010-07-01
... appliances. 17.150 Section 17.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Prosthetic, Sensory, and Rehabilitative Aids § 17.150 Prosthetic and similar appliances... appliances including invalid lifts and therapeutic and rehabilitative devices, and special clothing made...
The therapeutic threesome, Iodine 131, Lutetium-111 and Rhenium-188 Radionuclide Trifecta
International Nuclear Information System (INIS)
Turner, J.H.
2007-01-01
-limited and manageable. In a physician-sponsored Australian Phase II clinical study grade III/IV haematological toxicity occurred (4% platelets, 16% neutrophils). Objective response rate (ORR) was 76% and Complete Remission (CR) was achieved in 53% (3). The majority of our patients now qualify for outpatient radioimmuno-therapy with 131 Irituximab and monitoring of carer radiation exposure demonstrates that the IAEA and ICRP guidelines of less than 5 mSv per episode of treatment were satisfied in all carers, and visitors to the household were exposed to less than 1 mSv. First-line 131 I-rituximab is now given to patients presenting with newly diagnosed indolent stage IIB, III, IV follicular non-Hodgkin's lymphoma who do not wish to be exposed to the toxic effects of induction chemotherapy. In the INITIAL phase II clinical trial at Fremantle Hospital, after first-line 131 I-rituximab radioimmunotherapy, patients also undergo maintenance rituximab therapy to maintain remission. Clinical ORR is 100% with 80% CR in all patients, as evaluated by 18F-FDG PET imaging at 3 months. This is comparable with the reported ORR of first-line radioimmuno-therapy with 131 I-tositumomab (Bexxar) (4) and achieves the same ORR of standard R-CHOP chemotherapy regimens without the associated toxicity, or any requirement for hospital admission. 2. Lutetium-177 Octreotate Neuroendocrine malignancy is not amenable to chemotherapy and if unresectable due to metastases, usually in liver, the only effective treatment with intent-to cure is radiopeptide therapy. Lutetium-177 octreotate has been demonstrated to achieve ORR 45%, CR 2% (5) which is better than the results of the most effective but relatively more toxic chemotherapy regimen of Streptozotocin + 5FU + Doxorubicin. In an attempt to improve response rates we performed a pilot study of 177 Lu octreotate and capecitabine chemotherapy radiosensitizing therapy comprising 4 cycles of 7.4 GBq 177 Lu-octreotate with 2 weeks 1600 mg/m 2 capecitabine, at
B 150 civil engineering futures
DEFF Research Database (Denmark)
specific climatic challenge or clean the air. With nanotechnology, the artificial and the natural move closer together; this is the perspective for civil engineer Chris McCarthy’s work all over the world. And what is new is not just the way the construction materials are put together; they also require......Foreword B150 –Civil Engineering Futures consists of interviews made, articles written, and projects presented in connection with the 150th anniversary celebrations of the study of civil engineering in Denmark. Instead of a historical retrospect, it was decided to look into the future. What...... challenges will the next 150 years bring civil engineers? Researchers and lecturers at DTU’s Department of Civil Engineering (known as DTU Byg) suggested possible events, and we also consulted civil engineers and their business partners in the building industry. In this way, a programme was put together...
45 CFR 2490.150 - Program accessibility: Existing facilities.
2010-10-01
... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 2490.150 Section 2490.150 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON... ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.150 Program accessibility...
10 CFR 455.150 - Right to administrative review.
2010-01-01
... 10 Energy 3 2010-01-01 2010-01-01 false Right to administrative review. 455.150 Section 455.150 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND BUILDINGS OWNED BY UNITS OF LOCAL GOVERNMENT AND PUBLIC CARE INSTITUTIONS Administrative Review § 455.150 Right to...
Double-β decay Q value of 150Nd
International Nuclear Information System (INIS)
Kolhinen, V. S.; Eronen, T.; Gorelov, D.; Hakala, J.; Jokinen, A.; Kankainen, A.; Moore, I. D.; Rissanen, J.; Saastamoinen, A.; Suhonen, J.; Aeystoe, J.
2010-01-01
The double-β decay Q value of 150 Nd was determined by using the JYFLTRAP Penning trap mass spectrometer. The measured mass difference between 150 Nd and 150 Sm is 3371.38(20) keV. This new value deviates by 3.7 keV from the previously adopted value of 3367.7(22) keV and is a factor of 10 more precise. Accurate knowledge of this Q value is important because 150 Nd is a primary candidate to be used in the search for neutrinoless double-β decay modes in several experiments.
Preparation of A-150 tissue-equivalent plastic films
International Nuclear Information System (INIS)
Saion, E.B.; Shaari, A.H.; Watt, D.E.
1992-01-01
A-150 tissue-equivalent (TE) plastic is widely used as a wall material for tissue-equivalent proportional counters (TEPCS) used in experimental microdosimetry. The objective of this note is to give a technical account of how A-150 TE plastic film can be fabricated in the laboratory from commercially available A-150 TE plastic. (author)
International Nuclear Information System (INIS)
1992-05-01
The main goal of the Carem Project is the introduction of a Inherent Safe Nuclear Power Reactor in the range of low power (15 to 150 MWe). For this low-power application, light-water and low enriched uranium was selected, since using those concepts permits to take full advantage of the special characteristics of low power reactors. INVAP has been involved in the last years in the design and construction of a Carem Reactor, which could cover a range up to 150 MWe, using a multiple-unit approach. It would furnished the 150 MWe, using six Carem Reactors, of proper power, which would share most of the services. INVAP is a reliable supplier of not only the nuclear reactor but also of the fuel
32 CFR 150.5 - Place for filing papers.
2010-07-01
... 32 National Defense 1 2010-07-01 2010-07-01 false Place for filing papers. 150.5 Section 150.5... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.5 Place for filing papers. When the filing of a notice of appearance, brief, or other paper in the office of a Judge Advocate...
International Nuclear Information System (INIS)
Fernandez R, E.
2008-01-01
The stability constants of La 3+ , Pr 3+ , Eu 3+ , Er 3+ and Lu 3+ chloride complexes were determined in perchloric acid media using a liquid-liquid extraction method. The dinonyl napthalene sulfonic acid in n-heptane was used as extractant. The lanthanide (Ln) concentrations were measured by a radiochemical (Eu and Lu) and a spectrophotometric (La, Pr, and Er) methods. In the last method, xylenol orange was used for the determinations at ph 6. The stability constants of lanthanum, praseodymium, erbium and lutetium chloride complexes were determined in 2, 3 and 4 M ionic strength and europium in 1, 2 and 3 M, at 303 K. The fitting of experimental data to the equations for the calculation of the stability constants, was carry out considering both one chemical species (LnCl 2+ ) or two chemical species (LnCl 2+ and LnCl 2 + ). The Specific Ion Interaction Theory was applied to the values of log β I Ln , Cl and the first stability constants at zero ionic strength were calculated by extrapolation. The same theory could not be applied to the log β I Ln , 2Cl , due to its low abundance and the values determined for the stability constants were similar. The distribution diagrams of the chemical species were obtained using the program MEDUSA and considering log β I Ln , CI , log β I Ln , 2CI values obtained in this work and the hydrolysis constants taken from the literature. The lanthanide chloride complexes are present in solution at specific conditions of ionic strength, concentration and in the absence of hydrolysis. The log β I Ln , Cl data were related to the charge density and the corresponding equations were obtained. These equations could be used to determine the stability constants along the lanthanide series. (Author)
International Nuclear Information System (INIS)
Araujo, Bortoleti de; Pujatti, Priscilla Brunelli; Barrio, Ofelia; Caldeira, Jose S.; Mengatti, Jair; Suzuki, Miriam F.
2008-01-01
Pancreatic tumor (PT) is a neuroendocrine neoplasm that usually origin metastases in the respiratory and gastrointestinal tract. In recent years, new developments in targeted therapies have emerged and the presence of peptide receptors at the cell membrane of PT constitutes the basis of the clinical use of specific radiolabeled ligands. Substance P, an 11-amino acid peptide which has an important role in modulating pain transmission trough neurokinin 1 and 2 receptors (NKr), may play a role in the pathogenesis of PT, because approximately 10% of these tumors over express NKr. The aim of the present work was to produce a pure and stable SP analog (DOTA-SP) radiolabeled with Lutetium-177 ( 177 Lu), and to evaluate its in vivo target to AR42J pancreatic tumor cells in Nude mice in other to verify if SP can be used in this pancreatic tumor detection and treatment. 177 Lu (half-life 6.7 days) has both β and γ-emissions suitable for radiotherapy and imaging respectively. Substance P was successfully labeled with high yield (>99%) at optimized conditions and kept stable for more than 72 hours at 4 deg C and 24 hours in human plasma. Biodistribution studies showed that SP excretion was mainly performed by renal pathway. In addition, 177 Lu-DOTA-SP showed higher uptake by tumor than normal pancreas, indicating the presence of NK receptors in AR42J pancreatic tumor. (author)
40 CFR 46.150 - Request for applications.
2010-07-01
... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Request for applications. 46.150 Section 46.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... fellowship applications through electronic and printed announcements or other means designed to inform...
2007-01-01
2007. a. möödub 150 aastat Johann Voldemar Jannseni asutatud Pärnu Postimehe 1. numbri ilmumisest. Selle tähistamiseks avatakse Pärnus Rüütli tänava muulil 5. juunil 2007 Jannseni kuju (skulptor Mati Karmin)
The future of A-150 TE plastic
International Nuclear Information System (INIS)
Goodman, L.J.
1985-01-01
For the past 26 years a large number of laboratories have constructed or purchased ionization chambers, proportional counters, and phantoms made of A-150 tissue-equivalent plastic, and they have amassed a considerable amount of data and experience in its properties and uses. The United States National Bureau of Standards is now considering the desirability of supplying A-150 plastic as a research material with a certified homogeneity. We are, however, faced with a problem since the nylon used in A-150 has been discontinued by the manufacturer and the current stock of A-150 has been estimated to be adequate to supply the demand for only the next 2 or 3 years. Thus, it will be necessary to reformulate the plastic mixture we will be using in the future. This situation offers us the opportunity to change the composition of tissue-equivalent plastic to better conform to present-day requirements. To elucidate just what these requirements are, we have conducted a postal survey of the opinions of neutron dosimetrists and the results are presented and discussed. It is concluded that the present A-150 plastic and a future tissue-equivalent plastic formulation should be made research materials, and that a future tissue-equivalent plastic should be made to conform as closely as possible to the soft tissue composition given in ICRU Report 33
33 CFR 138.150 - Service of process.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Service of process. 138.150... Pollution (Vessels) § 138.150 Service of process. (a) When executing the forms required by this subpart... as its agent for service of process for purposes of this subpart and for receipt of notices of...
40 CFR 82.150 - Purpose and scope.
2010-07-01
...) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.150 Purpose and scope. (a) The purpose of this subpart is to reduce emissions of class I and class II refrigerants and their substitutes... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Purpose and scope. 82.150 Section 82...
Energy Technology Data Exchange (ETDEWEB)
Silva, Giovana Pasqualini da
2008-07-01
The {sup -} emitter {sup 177} Lu is a promising therapeutic radioisotope for the curative treatment of cancer using labelled proteins. It has a half - life of 6.71 day and maximum and average (3 energies of 421 and 133 keV, respectively, resulting in a short range of irradiation of tissue. The decay is accompanied by the emission of low energy -radiation of 208.3 keV (11%) and 113 keV (6.4%), suitable for simultaneous imaging. Lu can be produced by two different routes, namely, by irradiation of natural Lu{sub 2}O{sub 3} target ({sup 176}Lu, 2.6%) or enriched (in {sup 176}Lu) Lu{sub 2}O{sub 3} target, and also by irradiation of Yb target (Yb{sub 2}O{sub 3}) followed by radiochemical separation of Lu from Yb isotopes. The objective of this work is the development of a method of the production of {sup 177} Lu through of the (n, gamma) nuclear reaction, by the direct and indirect method of production. Targets of lutetium oxide and ytterbium oxide were irradiated for evaluation of the activity produced and the chemical separation of lutetium and ytterbium was studied using different ion exchange resins. For the direct method, the best results were obtained using the target Lu{sub 2}O{sub 3} enriched in 39.6%. The best results for the indirect method were achieved with the process of separation using 0.25M - HlBA as eluent. The results showed that it is possible to produce {sup 177} Lu of low specific activity for labeling molecules used for bone pain relief and in radiosynoviortesy. (author)
33 CFR 150.555 - How must cranes be maintained?
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false How must cranes be maintained? 150.555 Section 150.555 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Operations § 150.555 How must cranes be maintained? Cranes must be operated, maintained, and tested in...
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...
2010-10-01
... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...
International Nuclear Information System (INIS)
Awschalom, M.; Rosenberg, I.; Ten Haken, R.K.; Pearson, D.W.; DeLuca, P.M. Jr.; Attix, F.H.
1982-01-01
The average energy necessary to produce an electron-ion pair (anti W) of a gas mixture having an atomic composition very close to that of A-150 plastic has been studied through use in different size ionization chambers made of that plastic in a p(66)Be(49) neutron therapy beam. A tentative value for anti W(A-150-gas) of 27.3 +/ -0.5 J C -1 was derived. The anti W value of the A-150 equivalent gas mixture is compared to those of methane-based tissue-equivalent gas and of air for the p(66)Be(49) neutron beam as well as to corresponding values found in similar experiments using 14.8 MeV monoenergetic neutrons
22 CFR 711.150 - Program accessibility: Existing facilities.
2010-04-01
... result in a fundamental alteration in the nature of a program or activity or in undue financial and....150 Section 711.150 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE PROVISIONS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY...
46 CFR 180.150 - Survival craft embarkation arrangements.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft embarkation arrangements. 180.150 Section... (UNDER 100 GROSS TONS) LIFESAVING EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 180.150 Survival craft embarkation arrangements. (a) A launching appliance approved under approval...
Directory of Open Access Journals (Sweden)
Francesca Messina
2011-08-01
Full Text Available This preview of the Festival della Scienza 2011 focuses on a major initiative celebrating 150 years of Italian scientific research. Run jointly by the Italian Research Council (CNR and the Associazione Festival della Scienza, the project presents outstanding achievements in various fields including neuroscience, web technologies, genetics, chemistry and much more.
5 CFR 1636.150 - Program accessibility: Existing facilities.
2010-01-01
... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens... facilities. 1636.150 Section 1636.150 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL...
21 CFR 150.141 - Artificially sweetened fruit jelly.
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Artificially sweetened fruit jelly. 150.141 Section 150.141 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... locust bean gum), guar gum, gum karaya, gum tragacanth, algin (sodium alginate), sodium...
49 CFR 28.150 - Program accessibility: Existing facilities.
2010-10-01
... 49 Transportation 1 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 28.150 Section 28.150 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28...
33 CFR 150.616 - What are the requirements for lockout?
2010-07-01
... lockout? 150.616 Section 150.616 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Lockout/tagout § 150.616 What are the requirements for lockout? The deepwater port operator must ensure that, if...
33 CFR 150.617 - What are the requirements for tagout?
2010-07-01
... tagout? 150.617 Section 150.617 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Lockout/tagout § 150.617 What are the requirements for tagout? (a) The deepwater port operator must ensure that, before...
10 CFR 72.150 - Instructions, procedures, and drawings.
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Instructions, procedures, and drawings. 72.150 Section 72... WASTE Quality Assurance § 72.150 Instructions, procedures, and drawings. The licensee, applicant for a... documented instructions, procedures, or drawings of a type appropriate to the circumstances and shall require...
12 CFR 410.150 - Program accessibility: Existing facilities.
2010-01-01
... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Program accessibility: Existing facilities. 410.150 Section 410.150 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY EXPORT-IMPORT BANK OF THE UNITED...
46 CFR 117.150 - Survival craft embarkation arrangements.
2010-10-01
... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft embarkation arrangements. 117.150 Section... EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 117.150 Survival craft embarkation... apparatus when either— (1) The embarkation station for the survival craft is on a deck more than 4.5 meters...
Kurokawa 150-kW wind turbine generator demonstration; 150 kW Kurokawa furyoku hatsudensho ni tsuite
Energy Technology Data Exchange (ETDEWEB)
Okamoto, M; Shinohara, M; Sugiyama, T [Kansai Electric Power Co. Inc., Osaka (Japan)
1996-10-27
This paper presents the 150kW wind turbine generator erected at a site near Kurokawa dam lake of Kansai Electric Power Co. in Hyogo prefecture. This generator is composed of a horizontal-axis propeller with 3 blades of 27m in diameter and 36/27rpm, and a tower of 30m high. Harmony with the environment was also considered because of the site in a natural park area. Its demonstration test started in Oct. 1996 at annual mean wind velocity of 2m/s. Soft start was realized by controlling inrush current and preventing voltage drop in system interconnection by use of a thyristor circuit. The dual operation system was adopted of a 30kW small generator at lower wind velocity and a 150kW large one at higher velocity. Two kinds of brakes are used, and rotor revolution was reduced by air brake (blade tip spoiler). Mechanical disk brake works for the stopped rotor or emergency stopping. Even if the wind turbine was stopped by exterior factor, if no anomaly of the turbine is found, it automatically re-starts after removal of the factor. The generator is controlled from a remote control station 150km apart through NTT communication line. 6 figs., 2 tabs.
Olmstead, Craig; Cruz, Kyle; Stodilka, Robert; Zabel, Pamela; Wolfson, Robert
2015-02-01
Radionuclide therapies, including treatment of neuroendocrine tumors with lutetium-177 (Lu-177) octreotate, often involve hospital admission to minimize radiation exposure to the public. Overnight admission due to Lu-177 octreotate therapy incurs additional cost for the hospital and is an inconvenience for the patient. This study endeavors to characterize the potential radiation risk to caregivers and the public should Lu-177 octreotate therapies be performed on an outpatient basis. Dose rate measurements of radiation emanating from 10 patients were taken 30 min, 4, and 20 h after initiation of Lu-177 octreotate therapy. Instadose radiation dose measurement monitors were also placed around the patients' rooms to assess the potential cumulative radiation exposure during the initial 30 min-4 h after treatment (simulating the hospital-based component of the outpatient model) as well as 4-20 h after treatment (simulating the discharged outpatient portion). The mean recorded dose rate at 30 min, 4, and 20 h after therapy was 20.4, 14.0, and 6.6 μSv/h, respectively. The majority of the cumulative dose readings were below the minimum recordable threshold of 0.03 mSv, with a maximum dose recorded of 0.18 mSv. Given the low dose rate and cumulative levels of radiation measured, the results support that an outpatient Lu-177 octreotate treatment protocol would not jeopardize public safety. Nevertheless, the concept of ALARA still requires that detailed radiation safety protocols be developed for Lu-177 octreotate outpatients to minimize radiation exposure to family members, caregivers, and the general public.
21 CFR 146.150 - Canned concentrated orange juice.
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is not...
10 CFR 150.7 - Persons in offshore waters not exempt.
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Persons in offshore waters not exempt. 150.7 Section 150.7... AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Continued Commission Regulatory Authority in Offshore Waters § 150.7 Persons in offshore waters not exempt. Persons in offshore waters are not exempt...
2010-01-01
... inspected for the fresh avocado market. In addition, each handler shall provide the number of avocados... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Rules and Regulations § 915.150 Reports. (a) Each handler shall file with the Avocado Administrative...
2010-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.150 Submission. (a) The owner or operator shall... processes. The RMP shall be submitted in the method and format to the central point specified by EPA as of...
21 CFR 556.150 - Chlortetracycline.
2010-04-01
... DRUGS, FEEDS, AND RELATED PRODUCTS TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD Specific Tolerances for Residues of New Animal Drugs § 556.150 Chlortetracycline. (a) Acceptable daily intake (ADI... established for the sum of tetracycline residues in tissues of beef cattle, nonlactating dairy cows, calves...
2010-07-01
... FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.150 General. (a) Applicability. This subpart describes the product chemistry data that are required to support the registration... characteristics must be considered. (iv) Certain data are needed as basic or supportive evidence in initiating or...
Application of A150-plastic equivalent gases in microdosimetric measurements
International Nuclear Information System (INIS)
DeLuca, P.M. Jr.; Higgins, P.D.; Pearson, D.W.; Schell, M.; Attix, F.H.
1981-01-01
Neutron dosimetry measurements with ionization chambers, for the most part, employ tissue equivalent plastic-walled cavities (Shonka A150) filled with either air or a methane-base tissue-like gas. The atomic composition of TE-gas and A150 plastic are not matched and are quite dissimilar from muscle. Awschalom and Attix (1980) have partially resolved the problem by formulating a novel A150-plastic equivalent gas. This establishes a homogeneous wall-gas cavity dosimeter for neutron measurements and confines the necessary corrections to the applications of kerma ratios. In this report, we present measurements of applications of two A150-plastic equivalent gases in a low pressure spherical proportional counter. Gas gains and alpha-particle resolutions were determined. For these A150-mixtures as well as a methane-based TE-gas and an Ar-CO 2 mixture, we report measurements of event size distributions from exposure to a beam of 14.8 MeV neutrons
10 CFR 600.150 - Purpose of reports and records.
2010-01-01
... recipient's financial and program performance and the necessary standard reporting forms. They also set... 10 Energy 4 2010-01-01 2010-01-01 false Purpose of reports and records. 600.150 Section 600.150 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform...
International Nuclear Information System (INIS)
Pujatti, Priscilla Brunelli; Barrio, Ofelia; Santos, Josefina da Silva; Mengatti, Jair; Araujo, Elaine Bortoleti de
2008-01-01
Bombesin (BBN), a 14-aminoacid amphibian peptide homologue of mammalian gastrin-releasing peptide (GRP), has demonstrated the ability to bind with high affinity and specificity to GRP receptor, which are overexpressed on a variety of human cancers. A large number of BBN analogs were synthesized for this purpose and have shown to reduce tumor growth in mice. However, most of the studied analogs exhibit high abdominal accumulation, specially in pancreas. This abdominal accumulation may represent a problem in clinical use of radiolabeled bombesin analogs probably due to serious side effects to patients. In this study we describe the results of radiolabeling with lutetium-177 ( 177 Lu) and in vivo biodistribution and pharmacokinetics studies in normal Balb-C mice of a novel bombesin analog (BBNp4) - DOTA-X-BBN(6-14), where X is a spacer of four aminoacids. This spacer was inserted between the chelator and the binding sequence in order to improve bombesin in vivo properties. BBNp4 was successfully labeled with high yield and kept stable for more than 96 hours at 4 deg C and 4 hours in human plasma. Data analysis obtained from the in vivo studies showed that the amount of BBNp4 present in plasma decreased rapidly and became almost undetectable at 60 min p.i., indicating rapid peptide excretion, which is performed mainly by renal pathway. In addition, biodistribution and single photon emission tomography showed low abdominal accumulation of 177 Lu-DOTA-X-BBN(6-14), indicating that this analog is a potential candidate for tumors target therapy. (author)
Bmi-1 confers adaptive radioresistance to KYSE-150R esophageal carcinoma cells
Energy Technology Data Exchange (ETDEWEB)
Wang, Guanyu [Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Liu, Luying [Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou (China); Sharma, Sherven [David Geffen School of Medicine at UCLA, and the Department of Veterans Affairs, Los Angeles, CA (United States); Liu, Hai; Yang, Weifang; Sun, Xiaonan [Department of Radiotherapy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Dong, Qinghua, E-mail: dongqinghua@zju.edu.cn [Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou (China)
2012-08-24
Highlights: Black-Right-Pointing-Pointer Adaptive radioresistant KYSE-150R cells expressed high level of Bmi-1. Black-Right-Pointing-Pointer Bmi-1 depletion sensitized KYSE-150R cells to RT. Black-Right-Pointing-Pointer Bmi-1 depletion increased the generation of ROS in KYSE-150R cells exposed to radiation. Black-Right-Pointing-Pointer Bmi-1 depletion impaired DNA repair capacities in KYSE-150R cells exposed to radiation. -- Abstract: Radiotherapy (RT) is a major modality of cancer treatment. However, tumors often acquire radioresistance, which causes RT to fail. The exact mechanisms by which tumor cells subjected to fractionated irradiation (FIR) develop an adaptive radioresistance are largely unknown. Using the radioresistant KYSE-150R esophageal squamous cell carcinoma (ESCC) model, which was derived from KYSE-150 parental cells using FIR, the role of Bmi-1 in mediating the radioadaptive response of ESCC cells to RT was investigated. The results showed that the level of Bmi-1 expression was significantly higher in KYSE-150R cells than in the KYSE-150 parental cells. Bmi-1 depletion sensitized the KYSE-150R cells to RT mainly through the induction of apoptosis, partly through the induction of senescence. A clonogenic cell survival assay showed that Bmi-1 depletion significantly decreased the radiation survival fraction in KYSE-150R cells. Furthermore, Bmi-1 depletion increased the generation of reactive oxygen species (ROS) and the expression of oxidase genes (Lpo, Noxo1 and Alox15) in KYSE-150R cells exposed to irradiation. DNA repair capacities assessed by {gamma}-H2AX foci formation were also impaired in the Bmi-1 down-regulated KYSE-150R cells. These results suggest that Bmi-1 plays an important role in tumor radioadaptive resistance under FIR and may be a potent molecular target for enhancing the efficacy of fractionated RT.
10 CFR 150.20 - Recognition of Agreement State licenses.
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Recognition of Agreement State licenses. 150.20 Section 150.20 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY... the activities authorized, for an unlimited period of time. (5) Shall comply with all terms and...
Measurement of high energy neutrons via Lu(n,xn) reactions
International Nuclear Information System (INIS)
Henry, E.A.; Becker, J.A.; Archer, D.E.; Younes, W.; Stoyer, M.A.; Slaughter, D.
1997-07-01
High energy neutrons can be assayed by the use of the nuclear diagnostic material lutetium. We are measuring the (n,xn) cross sections for natural lutetium in order to develop it as a detector material. We are applying lutetium to diagnose the high energy neutrons produced in test target/blanket systems appropriate for the Accelerator Production of Tritium Project. 3 refs., 5 figs., 1 tab
The Rijksherbarium, 150 years old
NN,
1979-01-01
On March 29 and 30, 1979, the Rijksherbarium at Leiden commemorated in a modest way its foundation by King William I, 150 years ago. On the first day of the celebration a large company, including several distinguished foreign botanists, gathered in the old central building of the University for a
Prognostic role of microRNA-150 in various carcinomas: a meta-analysis
Directory of Open Access Journals (Sweden)
Wang W
2016-03-01
Full Text Available Wei Wang, Xinshuai Wang, Yali Zhang, Dan Wang, Hui Gao, Lijuan Wang, Shegan Gao Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China Objective: MicroRNA-150 (miR-150 was revealed to be an attractive prognostic biomarker in recent studies. However, the prognostic significance of miR-150 expression in cancer remains inconclusive. The aim of this study was to summarize the global predicting role of miR-150 in survival in patients with various carcinomas.Methods: Eligible studies were identified through multiple search strategies. Data were extracted from the studies by investigating the relationship between miR-150 expression and survival in patients with cancer. A meta-analysis of the hazard ratio (HR was then performed to evaluate the prognostic role of miR-150 in different tumors. Pooled HRs of miR-150 for overall survival and progression-free survival were calculated to measure the effect of miR-150 expression on prognosis.Results: This meta-analysis included nine published studies concerning various carcinomas. Our results indicate that an elevated miR-150 expression is associated with an enhanced overall survival in the digestive tract cancer subgroup (HR =0.57, 95% confidence interval [CI]: 0.37–0.90 and a poor progression-free survival in various cancers (HR =3.08, 95% CI: 2.00–4.75.Conclusion: miR-150 may have the potential to become a new useful prognostic factor to monitor cancer prognosis and progression. However, given the current insufficient relevant data, further clinical studies are needed. Keywords: microRNA-150, carcinomas, prognosis, meta-analysis
32 CFR 150.21 - Appeals by the United States.
2010-07-01
... 32 National Defense 1 2010-07-01 2010-07-01 false Appeals by the United States. 150.21 Section 150... the United States. (a) Restricted filing. Only a representative of the government designated by the Judge Advocate General of the respective service may file an appeal by the United States under Article...
African American Accounting Majors and the 150-hr Requirement
Booker, Quinton; Hill, Cecil L.; Wright, Carl
2010-01-01
The study provides information on African American accounting majors' views regarding 150-hr issues. The authors collected data from 152 students at two schools. Students at one school supported the requirement while those at the other school did not. However, students believed that the 150-hr requirement enhances the quality of certified public…
MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection.
Ouattara, Louise A; Barnable, Patrick; Mawson, Paul; Seidor, Samantha; Zydowsky, Thomas M; Kizima, Larisa; Rodriguez, Aixa; Fernández-Romero, José A; Cooney, Michael L; Roberts, Kevin D; Gettie, Agegnehu; Blanchard, James; Robbiani, Melissa; Teleshova, Natalia
2014-05-01
Recent studies demonstrated that intravaginal rings (IVRs) containing 100 mg of the nonnucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 significantly protect macaques against a chimeric simian-human immunodeficiency virus that expresses the HIV-1 HxB2 reverse transcriptase (SHIV-RT) when present before and after vaginal challenge. The objectives of this study were to (i) evaluate the pharmacodynamics (PD) of MIV-150 in vaginal fluids (VF) and in ectocervical and vaginal tissues following 100-mg MIV-150 IVR exposure and to (ii) gain more insight whether pharmacokinetics (PK) of MIV-150 can predict PD. MIV-150 in VF collected at 1 day and 14 days post-MIV-150 IVR insertion inhibited ex vivo SHIV-RT infection in vaginal biopsy specimens from untreated animals (not carrying IVRs) in a dose-dependent manner. Previous PK studies demonstrated a significant increase of ectocervical and vaginal tissue MIV-150 concentrations 14 days versus 1 day post-IVR insertion, with the highest increase in vaginal tissue. Therefore, we tested PD of MIV-150 in tissues 14 days post-MIV-150 IVR insertion. Ex vivo SHIV-RT infection of vaginal, but not ectocervical, tissues collected 14 days post-MIV-150 IVR insertion was significantly inhibited compared to infection at the baseline (prior to MIV-150 IVR exposure). No changes in vaginal and ectocervical tissue infection were observed after placebo IVR exposure. Overall, these data underscore the use of the ex vivo macaque explant challenge models to evaluate tissue and VF PK/PD of candidate microbicides before in vivo animal efficacy studies. The data support further development of MIV-150-containing IVRs.
33 CFR 150.507 - How must the operator service inflatable lifesaving appliances?
2010-07-01
... inflatable lifesaving appliances? 150.507 Section 150.507 Navigation and Navigable Waters COAST GUARD... Specialty Equipment Inflatable Lifesaving Appliances § 150.507 How must the operator service inflatable lifesaving appliances? (a) The operator must service each inflatable liferaft according to 46 CFR subpart 160...
150 Passenger Commercial Aircraft
Bucovsky, Adrian; Romli, Fairuz I.; Rupp, Jessica
2002-01-01
It has been projected that the need for a short-range mid-sized, aircraft is increasing. The future strategy to decrease long-haul flights will increase the demand for short-haul flights. Since passengers prefer to meet their destinations quickly, airlines will increase the frequency of flights, which will reduce the passenger load on the aircraft. If a point-to-point flight is not possible, passengers will prefer only a one-stop short connecting flight to their final destination. A 150-passenger aircraft is an ideal vehicle for these situations. It is mid-sized aircraft and has a range of 3000 nautical miles. This type of aircraft would market U.S. domestic flights or inter-European flight routes. The objective of the design of the 150-passenger aircraft is to minimize fuel consumption. The configuration of the aircraft must be optimized. This aircraft must meet CO2 and NOx emissions standards with minimal acquisition price and operating costs. This report contains all the work that has been performed for the completion of the design of a 150 passenger commercial aircraft. The methodology used is the Technology Identification, Evaluation, and Selection (TIES) developed at Georgia Tech Aerospace Systems Design laboratory (ASDL). This is an eight-step conceptual design process to evaluate the probability of meeting the design constraints. This methodology also allows for the evaluation of new technologies to be implemented into the design. The TIES process begins with defining the problem with a need established and a market targeted. With the customer requirements set and the target values established, a baseline concept is created. Next, the design space is explored to determine the feasibility and viability of the baseline aircraft configuration. If the design is neither feasible nor viable, new technologies can be implemented to open up the feasible design space and allow for a plausible solution. After the new technologies are identified, they must be evaluated
21 CFR 150.161 - Artificially sweetened fruit preserves and jams.
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Artificially sweetened fruit preserves and jams. 150.161 Section 150.161 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... karaya, gum tragacanth, algin (sodium alginate), sodium carboxymethylcellulose (cellulose gum...
Oncology pharma costs to exceed $150 billion by 2020.
2016-10-01
Worldwide costs of oncology drugs will rise above $150 billion by 2020, according to a report by the IMS Institute for Healthcare Informatics. Many factors are in play, according to IMS, including the new wave of expensive immunotherapies. Pembrolizumab (Keytruda), priced at $150,000 per year per patient, and nivolumab (Opdivo), priced at $165,000, may be harbingers of the market for cancer immunotherapies.
33 CFR 110.150 - Block Island Sound, N.Y.
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island Sound, N.Y. 110.150... ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A 3/4... following coordinates: latitude 41°06′12″ N., longitude 72°00′05″ W., latitude 41°07′40″ N., longitude 72°01...
10 CFR 150.19 - Submission to Commission of tritium reports.
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Submission to Commission of tritium reports. 150.19... Agreement States § 150.19 Submission to Commission of tritium reports. (a)-(b) [Reserved] (c) Except as... authorized to possess tritium shall report promptly to the appropriate NRC Regional Office as shown in...
46 CFR Appendix II to Part 150 - Explanation of Figure 1
2010-10-01
... COMPATIBILITY OF CARGOES Pt. 150, App. II Appendix II to Part 150—Explanation of Figure 1 Definition of a..., aromatic hydrocarbons or paraffins. Others will form hazardous combinations with many groups: For example...
21 CFR 801.150 - Medical devices; processing, labeling, or repacking.
2010-04-01
... originally processed or packed, shall be exempt, during the time of introduction into and movement in... otherwise accounting for the number of units in each shipment to insure that the number of units shipped is... repacking. 801.150 Section 801.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND...
42 CFR 457.150 - CMS review of State plan material.
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false CMS review of State plan material. 457.150 Section... Introduction; State Plans for Child Health Insurance Programs and Outreach Strategies § 457.150 CMS review of State plan material. (a) Basis for action. CMS reviews each State plan and plan amendment to determine...
14 CFR Appendix A to Part 150 - Noise Exposure Maps
2010-01-01
... 150 under § 150.11. For purposes of this part, the tolerances allowed for general purpose, type 2... Y Y Y Y Recreational Outdoor sports arenas and spectator sports Y Y(5) Y(5) N N N Outdoor music... average-daily-basis, the number of aircraft, by type of aircraft, which utilize each flight track, in both...
Directory of Open Access Journals (Sweden)
Nanyu Han
Full Text Available Neuraminidase (NA of influenza is a key target for antiviral inhibitors, and the 150-cavity in group-1 NA provides new insight in treating this disease. However, NA of 2009 pandemic influenza (09N1 was found lacking this cavity in a crystal structure. To address the issue of flexibility of the 150-loop, Hamiltonian replica exchange molecular dynamics simulations were performed on different groups of NAs. Free energy landscape calculated based on the volume of 150-cavity indicates that 09N1 prefers open forms of 150-loop. The turn A (residues 147-150 of the 150-loop is discovered as the most dynamical motif which induces the inter-conversion of this loop among different conformations. In the turn A, the backbone dynamic of residue 149 is highly related with the shape of 150-loop, thus can function as a marker for the conformation of 150-loop. As a contrast, the closed conformation of 150-loop is more energetically favorable in N2, one of group-2 NAs. The D147-H150 salt bridge is found having no correlation with the conformation of 150-loop. Instead the intimate salt bridge interaction between the 150 and 430 loops in N2 variant contributes the stabilizing factor for the closed form of 150-loop. The clustering analysis elaborates the structural plasticity of the loop. This enhanced sampling simulation provides more information in further structural-based drug discovery on influenza virus.
2010-04-01
... is the purpose investment). (B) Recycling of certain payments under purpose investments. A conduit... for all purposes of sections 103 and 141 through 150. (2) Effective date—(i) In general. Except as... obligor on a purpose investment (as defined in § 1.148-1). For example, if an issuer invests proceeds in a...
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation.
Ban, Young Ho; Oh, Se-Chan; Seo, Sang-Hwan; Kim, Seok-Min; Choi, In-Pyo; Greenberg, Philip D; Chang, Jun; Kim, Tae-Don; Ha, Sang-Jun
2017-09-12
MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8 + T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8 + T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8 + T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8 + T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8 + T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
Energy Technology Data Exchange (ETDEWEB)
Boehm, H. [Siemens AG Unternehmensbereich KWU, Erlangen (Germany). Bereich Energieerzeugung
1997-12-01
The development of power plant construction both in the last 150 years and also relative to the deduced major trends for the future is illustrated by the important milestones. In this respect, the important role of modern power stations is very prominent in ensuring enduring economic development. (orig.) [Deutsch] Anhand von wichtigen Meilensteinen wird die Entwicklung im Kraftwerksbau sowohl in den letzten 150 Jahren als auch entsprechend den sich abzeichnenden grossen Trends fuer die Zukunft beleuchtet. Dabei steht die wichtige Rolle moderner Kraftwerke fuer eine nachhaltige Entwicklung im Vordergrund. (orig.)
Neutron flux stabilization in the NG-150 neutron generators
International Nuclear Information System (INIS)
Kuz'min, L.E.; Makarov, S.A.; Pronman, I.M.
1986-01-01
Problem of metal tritium target lifetime increase and neutron flux stabilization in the NG-150 neutron generators is studied. Possibility on neutron flux stabilization using the mass analyzer for low-angle (4 deg and 41 deg) mass separation of a beam in thre components, which fall on a target simultaneously, is confirmed experimentally. Basic generator parameters are: accelerating voltage of 150 kV, total beam current on a target of 1.5 mA, beam current density of 0.3-1.6 mA/cm 2 , beam diameter of 8 mm. The initial neutron flux on the targets of 0.73 mg/cm 2 thick constituted 1.1x10 11 ssup(-1). The neutron flux monitoring was accomplished from recoil proton recording by a plastic scintillator. Flux decrease by more than 5% served as a signel for measuring mass analyzer magnetic field providing beam displacement on a target and restoration of the given flux. The NG-150 generator neutron flux stabilization was attained during 2h
2010-06-17
... Airworthiness Directives; Honeywell International Inc. Auxiliary Power Unit Models GTCP36-150(R) and GTCP36-150...) models GTCP36- 150(R) and GTCP36-150(RR). This AD requires inspecting the fuel control unit (FCU...-150(R) and GTCP36-150(RR). We published the proposed AD in the Federal Register on December 23, 2009...
miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb
Directory of Open Access Journals (Sweden)
Zeyu Chen
2017-09-01
Full Text Available MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb, such as Bcl-2 and Bcl-xL, were also increased, suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit.
21 CFR 139.150 - Noodle products.
2010-04-01
... § 139.150 Noodle products. (a) Noodle products are the class of food each of which is prepared by drying... leaf, or any two or more of these, in a quantity which seasons the food. (2) Salt, in a quantity which... in with the common name of the ingredient; or in the case of bay leaves, the statement “Spiced...
Energy Technology Data Exchange (ETDEWEB)
Li, Jing [Department of Geratory, Linzi District People’s Hospital of Zibo City, Zibo, Shandong (China); Zhang, Suhua, E-mail: drsuhuangzhang@qq.com [Department of HealthCare, Qilu Hospital of Shandong University (Qingdao), Qingdao City, Qingdao (China)
2016-08-05
Transformation of macrophages into foam cells plays a critical role in the pathogenesis of atherosclerosis. The aim of this study was to determine the expression and biological roles of microRNA (miR)-150 in the formation of macrophage foam cells and to identify its functional target(s). Exposure to 50 μg/ml oxidized low-density lipoprotein (oxLDL) led to a significant upregulation of miR-150 in THP-1 macrophages. Overexpression of miR-150 inhibited oxLDL-induced lipid accumulation in THP-1 macrophages, while knockdown of miR-150 enhanced lipid accumulation. apoA-I- and HDL-mediated cholesterol efflux was increased by 66% and 43%, respectively, in miR-150-overexpressing macrophages relative to control cells. In contrast, downregulation of miR-150 significantly reduced cholesterol efflux from oxLDL-laden macrophages. Bioinformatic analysis and luciferase reporter assay revealed adiponectin receptor 2 (AdipoR2) as a direct target of miR-150. Small interfering RNA-mediated downregulation of AdipoR2 phenocopied the effects of miR-150 overexpression, reducing lipid accumulation and facilitating cholesterol efflux in oxLDL-treated THP-1 macrophages. Knockdown of AdipoR2 induced the expression of proliferator-activated receptor gamma (PPARγ), liver X receptor alpha (LXRα), ABCA1, and ABCG1. Moreover, pharmacological inhibition of PPARγ or LXRα impaired AdipoR2 silencing-induced upregulation of ABCA1 and ABCG1. Taken together, our results indicate that miR-150 can attenuate oxLDL-induced lipid accumulation in macrophages via promotion of cholesterol efflux. The suppressive effects of miR-150 on macrophage foam cell formation are mediated through targeting of AdipoR2. Delivery of miR-150 may represent a potential approach to prevent macrophage foam cell formation in atherosclerosis. -- Highlights: •miR-150 inhibits macrophage foam cell formation. •miR-150 accelerates cholesterol efflux from oxLDL-laden macrophages. •miR-150 suppresses macrophage foam cell
Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.
Directory of Open Access Journals (Sweden)
Olga Romanets-Korbut
Full Text Available CD150 (IPO3/SLAM belongs to the SLAM family of receptors and serves as a major entry receptor for measles virus. CD150 is expressed on normal and malignant cells of the immune system. However, little is known about its expression outside the hematopoietic system, especially tumors of the central nervous system (CNS. Although CD150 was not found in different regions of normal brain tissues, our immunohistochemical study revealed its expression in 77.6% of human CNS tumors, including glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, ependymoma, and others. CD150 was detected in the cytoplasm, but not on the cell surface of glioma cell lines, and it was colocalized with the endoplasmic reticulum and Golgi complex markers. In addition to the full length mRNA of the mCD150 splice isoform, in glioma cells we found a highly expressed novel CD150 transcript (nCD150, containing an 83 bp insert. The insert is derived from a previously unrecognized exon designated Cyt-new, which is located 510 bp downstream of the transmembrane region exon, and is a specific feature of primate SLAMF1. Both mCD150 and nCD150 cDNA variants did not contain any mutations and had the leader sequence. The nCD150 transcript was also detected in normal and malignant B lymphocytes, primary T cells, dendritic cells and macrophages; however, in glioma cells nCD150 was found to be the predominant CD150 isoform. Similarly to mCD150, cell surface expression of nCD150 allows wild type measles virus entry to the cell. Our data indicate that CD150 expression in CNS tumors can be considered a new diagnostic marker and potential target for novel therapeutic approaches.
2010-07-01
... detergents, including but not limited to assembly and storage of raw materials, crutching, spray drying... manufacture of spray dried detergents subcategory. 417.150 Section 417.150 Protection of Environment... POINT SOURCE CATEGORY Manufacture of Spray Dried Detergents Subcategory § 417.150 Applicability...
International Nuclear Information System (INIS)
Liu, Liwan; Shao, Chongyun; Zhang, Yu; Liao, Xili; Yang, Qiuhong; Hu, Lili; Chen, Danping
2016-01-01
Ce 3+ -doped Gd 2 O 3 -based scintillation glasses are prepared within an air or CO atmosphere. The effects of fluorine, lutetium, barium, and the melting atmosphere on the optical properties, scintillation properties and irradiation hardness are studied. Absorption spectra, luminescence spectra under UV and X-ray excitation, and the X-ray radiation-induced spectra are presented. The results show that the density can be increased by doping with fluorine, lutetium and barium. The luminescence intensity decreases after X-ray irradiation. Because of charge transfer quenching, fluorine and lutetium enhance the UV-excited and X-ray excited luminescence intensity, but barium decreases. Moreover, fluorine and lutetium are advantageous to irradiation hardness while barium is not. In addition, a non-reducing atmosphere provides a higher irradiation hardness than a reducing atmosphere. Fluorine-doped glass is promising to enhance luminescence intensity, promote irradiation hardness, and increase the density.
Performance of a 150-MW S-band klystron
International Nuclear Information System (INIS)
Sprehn, D.; Phillips, R.M.; Caryotakis, G.
1994-09-01
As part of an international collaboration, the Stanford Linear Accelerator Center (SLAC) klystron group has designed, fabricated, and tested a 60-Hz, 3-μs, 150-MW S-band klystron built for Deutsches Elektronen Synchrotron (DESY). A test diode with a 535-kV, 700-A electron beam was constructed to verify the gun operation. The first klystron was built and successfully met design specifications. The 375-MW electron beam represents a new record for SLAC accelerator klystrons in terms of voltage, current, energy, and ruggedness of design. The rf output power is a 150% increase over the S-band tubes currently used in the two-mile-long linear accelerator at SLAC. This paper discusses design issues and experimental results of the diode and klystron
45 CFR 150.313 - Market conduct examinations.
2010-10-01
..., or the operation of a non-Federal governmental plan, involving the review of one or more (or a combination) of a responsible entity's business or operational affairs, or both, to verify compliance with... Non-Federal Governmental Plans-Civil Money Penalties § 150.313 Market conduct examinations. (a...
24 CFR 943.150 - What procurement standards apply to a PHA's joint venture partner?
2010-04-01
... a PHA's joint venture partner? 943.150 Section 943.150 Housing and Urban Development Regulations... HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT PUBLIC HOUSING AGENCY CONSORTIA AND JOINT VENTURES Subsidiaries, Affiliates, Joint Ventures in Public Housing § 943.150 What procurement standards apply to a PHA...
miR-150-5p inhibits hepatoma cell migration and invasion by targeting MMP14.
Directory of Open Access Journals (Sweden)
Tao Li
Full Text Available Hepatocellular carcinoma (HCC is one of the leading causes of cancer-related mortality worldwide. Despite progress in diagnostics and treatment of HCC, its prognosis remains poor because the molecular mechanisms underlying hepatocarcinogenesis are not well understood. In the study, we focused on identifying the role of miRNAs in HCC progression. miRNA microarray was used to analyze the differentially expressed miRNAs, and the results were validated by qPCR. We found that the miR-150-5p expression is down-regulated in HCC tissues compared with pair non-tumor tissues. miR-150-5p expression is also decreased in metastatic cancer tissues compared with pair primary tissues, indicating that miR-150-5p may be involved in HCC metastasis. Functionally, miR-150-5p inhibition significantly promotes hepatoma cell migration and invasion, whereas miR-150-5p overexpression suppresses cancer cell migration and invasion in vitro. The matrix metalloproteinase 14 (MMP14 is identified as a new target gene of miR-150-5p. miR-150-5p markedly inhibits MMP14 expression in hepatoma cells, and miR-150-5p expression is negative correlation with MMP14 expression in vivo. More important, re-expression of MMP14 in hepatoma cells partially reverses the effect of miR-150-5p in inhibiting cell invasion.
Changes of Dielectric Properties induced by Fast neutrons in Tissue Equivalent Plastic A-150
International Nuclear Information System (INIS)
Abdou, M.S.
2000-01-01
Tissue equivalent plastic A-150 (TEP A-150) samples are exposed to fast neutrons. Dielectric studies for TEP A-150 are carried out in the frequency range from 40 Hz to 4 MHz in the temperature range 295-343 K. The obtained data revealed that, both the dielectric properties and conductivity sigma ac (omega) of TEP A-150 are altered when irradiated by a relatively high fast neutron dose (15 Sv). The values of dielectric constant and conductivity are increased for the irradiated samples to about 24% than the blank samples
MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death
Tang, Yaoping; Wang, Yongchao; Park, Kyoung-mi; Hu, Qiuping; Teoh, Jian-peng; Broskova, Zuzana; Ranganathan, Punithavathi; Jayakumar, Calpurnia; Li, Jie; Su, Huabo; Tang, Yaoliang; Ramesh, Ganesan; Kim, Il-man
2015-01-01
Aims Cardiac injury is accompanied by dynamic changes in the expression of microRNAs (miRs). For example, miR-150 is down-regulated in patients with acute myocardial infarction, atrial fibrillation, dilated and ischaemic cardiomyopathy as well as in various mouse heart failure (HF) models. Circulating miR-150 has been recently proposed as a better biomarker of HF than traditional clinical markers such as brain natriuretic peptide. We recently showed using the β-arrestin-biased β-blocker, carvedilol that β-arrestin1-biased β1-adrenergic receptor cardioprotective signalling stimulates the processing of miR-150 in the heart. However, the potential role of miR-150 in ischaemic injury and HF is unknown. Methods and results Here, we show that genetic deletion of miR-150 in mice causes abnormalities in cardiac structural and functional remodelling after MI. The cardioprotective roles of miR-150 during ischaemic injury were in part attributed to direct repression of the pro-apoptotic genes egr2 (zinc-binding transcription factor induced by ischaemia) and p2x7r (pro-inflammatory ATP receptor) in cardiomyocytes. Conclusion These findings reveal a pivotal role for miR-150 as a regulator of cardiomyocyte survival during cardiac injury. PMID:25824147
Drift velocities of 150-km Field-Aligned Irregularities observed by the Equatorial Atmosphere Radar
Directory of Open Access Journals (Sweden)
Yuichi Otsuka
2013-11-01
Full Text Available Between 130 and 170 km altitude in the daytime ionosphere, the so-called 150-km field-aligned irregularities (FAIs have been observed since the 1960s at equatorial regions with several very high frequency (VHF radars. We report statistical results of 150-km FAI drift velocities on a plane perpendicular to the geomagnetic field, acquired by analyzing the Doppler velocities of 150-km FAIs observed with the Equatorial Atmosphere Radar (EAR at Kototabang, Indonesia during the period from Aug. 2007 to Oct. 2009. We found that the southward/upward perpendicular drift velocity of the 150-km FAIs tends to decrease in the afternoon and that this feature is consistent with that of F-region plasma drift velocities over the magnetic equator. The zonal component of the 150-km FAI drift velocity is westward and decreases with time, whereas the F-region plasma drift velocity observed with the incoherent scatter radar at Jicamarca, Peru, which is westward, reaches a maximum at about noon. The southward/upward and zonal drift velocities of the 150-km FAIs are smaller than that of the F-region plasma drift velocity by approximately 3 m/s and 25 m/s, respectively, on average. The large difference between the 150-km FAI and F-region plasma drift velocities may not arise from a difference in the magnetic latitudes at which their electric fields are generated. Electric fields generated at the altitude at which the 150-km FAIs occur may not be negligible.
33 CFR 165.150 - New Haven Harbor, Quinnipiac River, Mill River.
2010-07-01
... River, Mill River. 165.150 Section 165.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... New Haven Harbor, Quinnipiac River, Mill River. (a) The following is a regulated navigation area: The... 303°T to point D at the west bank of the mouth of the Mill River 41°18′05″ N, 72°54′23″ W thence south...
2010-07-01
... Equipment Manual: Recording information after inspections. 157.150 Section 157.150 Navigation and Navigable... Vessels Inspections § 157.150 Crude Oil Washing Operations and Equipment Manual: Recording information... machines. (2) Revolutions, number of cycles, and length of cycles of each COW machine. (3) Pressure and...
33 CFR 150.705 - What are the requirements for maintaining and inspecting aids to navigation?
2010-07-01
... maintaining and inspecting aids to navigation? 150.705 Section 150.705 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Aids to Navigation § 150.705 What are the requirements for maintaining and inspecting aids to navigation? (a) All...
7 CFR 1260.150 - Duties of the Board.
2010-01-01
... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Cattlemen's Beef Promotion and Research Board § 1260.150 Duties of the Board...
[150 years of medical mycology].
Gemeinhardt, H
1990-04-01
A short survey concerning the development of the medical mycology is presented covering the last 150 years (1839-1989). According to the interpretation of most of the distinguished authors, the year of Schönlein's publication, i.e. 1839, is to be considered as the origin of the medical mycology. Therefore, mycoses were the first infectious diseases the etiology of which were scientifically explained. Monographs and articles in manuals written in the most important world languages represent milestones in the historical development. Over large periods connected to and promoted by dermatology, increasingly this special field has developed to an important and autonomous part of medical microbiology.
40 CFR 265.150 - State assumption of responsibility.
2010-07-01
..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.150 State assumption of responsibility. (a) If a State either assumes legal responsibility for an owner's or operator's compliance with the... 40 Protection of Environment 25 2010-07-01 2010-07-01 false State assumption of responsibility...
40 CFR 264.150 - State assumption of responsibility.
2010-07-01
... FACILITIES Financial Requirements § 264.150 State assumption of responsibility. (a) If a State either assumes legal responsibility for an owner's or operator's compliance with the closure, post-closure care, or... 40 Protection of Environment 25 2010-07-01 2010-07-01 false State assumption of responsibility...
40 CFR 261.150 - State assumption of responsibility.
2010-07-01
... Excluded Hazardous Secondary Materials § 261.150 State assumption of responsibility. (a) If a State either assumes legal responsibility for an owner's or operator's compliance with the closure or liability... 40 Protection of Environment 25 2010-07-01 2010-07-01 false State assumption of responsibility...
40 CFR 267.150 - State assumption of responsibility.
2010-07-01
... STANDARDIZED PERMIT Financial Requirements § 267.150 State assumption of responsibility. (a) If a State either assumes legal responsibility for an owner's or operator's compliance with the closure care or liability... 40 Protection of Environment 26 2010-07-01 2010-07-01 false State assumption of responsibility...
45 CFR 150.203 - Circumstances requiring CMS enforcement.
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Circumstances requiring CMS enforcement. 150.203... CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS CMS Enforcement Processes for... requiring CMS enforcement. CMS enforces HIPAA requirements to the extent warranted (as determined by CMS) in...
2010-07-01
... inflatable lifesaving appliances and marine evacuation systems? 150.506 Section 150.506 Navigation and...: OPERATIONS Emergency and Specialty Equipment Inflatable Lifesaving Appliances § 150.506 When must the operator service inflatable lifesaving appliances and marine evacuation systems? (a) The operator must...
29 CFR 2205.150 - Program accessibility: Existing facilities.
2010-07-01
...; (3) Specify the schedule for taking the steps necessary to achieve compliance with this section and, if the time period of the transition plan is longer than one year, identify steps that will be taken... Section 2205.150 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW...
Studies on the properties of poly(ethylene oxide) R-150 water-swollen hydrogel formed by irradiation
International Nuclear Information System (INIS)
Yang Zhanshan; Zhu Nankang; Yang Shuqin; Qiang Yizhong
2000-01-01
The physical and chemical properties of PEO R-150 water-swollen hydrogel films formed by electron beam irradiation are studied and compared with PEO R-150 hydrogel films. The experimental results show that the irradiation dose and mass fraction of the polymer do not produce a significant effect on the gel fraction, of the PEO R-150 water-swollen hydrogel films (P>0.05). The degrees of swelling of the PEO R-150 water-swollen hydrogel films decrease as the irradiation dose increasing (P 0.05). The results indicate that the saturant crosslinking density, the lowest degree of swelling of the PEO R-150 water-swollen hydrogel films produce and unfavorable effect on their machinery strength
17 CFR 150.6 - Responsibility of contract markets.
2010-04-01
... LIMITS ON POSITIONS § 150.6 Responsibility of contract markets. Nothing in this part shall be construed to affect any provisions of the Act relating to manipulation or corners nor to relieve any contract... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Responsibility of contract...
29 CFR 2706.150 - Program accessibility: Existing facilities.
2010-07-01
...; (3) Specify the schedule for taking the steps necessary to achieve compliance with this section and, if the time period of the transition plan is longer than one year, identify steps that will be taken... Section 2706.150 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW...
Studies of the radiolabeling and biodistribution of substance P using lutetium-177 as a radiotracer
International Nuclear Information System (INIS)
Lima, Clarice Maria de
2011-01-01
Malignant gliomas are primary brain tumors, resistant to various treatments, as chemotherapy, radiotherapy, induction of apoptosis and surgery. An alternative for the treatment of malignant gliomas is the radionuclide therapy. This technique apply radiolabeled molecules that selectively bind to tumor cells producing cytotoxic effect by dose irradiation, and resulting in death of tumor cells. Most protocols for radionuclide therapy of malignant brain tumors involve the administration of peptides labeled with β - emitting radioisotopes. The Substance P (SP) is an 11- amino acid neuropeptide, characterized by the C-terminal sequence Phe-X-Gly-Leu-Met-NH 2 . The use of SP labeled with different radionuclides including 177 Lu, have been proposed for in vivo treatment of tumors. SP is the most important target of neurokinin 1 receptors, over expressed in malignant gliomas. The objective of this work was to study conditions of radiolabeling DOTA-SP with 177 Lu, the stability of labeled compound and in vivo and in vitro, to develop a protocol production and evaluate the potential of the radiopharmaceutical in the therapy of gliomas. The labeling conditions were optimized varying the temperature, reaction time, activity of lutetium-177 chloride and mass of DOTA-SP. The radiochemical purity of preparations were analyzed by chromatographic techniques. The stability of 17L u -DOTA- SP radiolabeled with low activity of 177 Lu was evaluated for different time at 2-8 degree C or incubated in human serum. The stability of the labeled with high activity of 177 Lu was also analyzed in the presence of gentisic acid (6 mg / mL) added after the labeling reaction. The labeled conditions in low and high activity were subjected to evaluation for the ability to cause oxidation of methionine residue, adding the D-L- methionine amino acid to the reaction medium (6 mg / mL) and subsequent chromatographic evaluation. In vitro study with 177 Lu-DOTA-SP, radiolabeled in the absence and presence
The effect of HCV Core protein on the expression of miR-150
Directory of Open Access Journals (Sweden)
Sayad Khanizadeh
2016-09-01
Full Text Available Background : Hepatitis C virus (HCV is considered as one of the major pathogenic agents of chronic liver diseases. Previous studies have shown that HCV proteins can interaction with gene regulatory networks such as microRNAs. The aim of this study was to investigate the effect of HCV core protein on the expression of miR-150 in a cell culture model. Materials and Methods: Plasmids expressing full HCV core protein was transfected into Huh7 cell lines while a GFP expressing plasmid employed as negative control. Subsequently, total RNA extracted and Real-Time PCR performed to measure the expression level of miR-150 expression. Moreover, trypan blue exclusion assay was performed to investigate the effect of core protein on cell viability. Results: The gene expression analysis of miR-150 in Huh7 cells showed that endogenous HCV core protein could significantly down regulation of miR-150 when compared to GFP control plasmid and normal cells (P<0.01. Beside, core protein induced no significant proliferative or cytotoxic effects on hepatic cells as determined by trypan blue exclusion assay (P<0.05. Conclusion: Our study suggests that HCV core protein can led to down regulation of miR-150 expression. This data revealed that HCV protein interactions with cell regulatory machinery may contribute to pathogenesis of chronic liver diseases.
International Nuclear Information System (INIS)
Noro, Junji; Sekine, Tatsuya.
1993-01-01
The solvent extractions of lanthanum(III), europium(III), and lutetium(III) (M 3+ ) in 0.1 moldm -3 sodium nitrate solutions with 5,7-dichloro-8-quinolinol (HA) into chloroform were studied in both the absence and presence of tetrabutylammonium ions (tba + ) or trioctylphosphine oxide (TOPO). In the absence of tba + or TOPO, the extracted species were the MA 3 and MA H A (self-adduct), though MA 4 - tba + was found when tba + was added; MA 3 TOPO and MA 3 (TOPO) 2 were found when TOPO was added in addition to the above mentioned two species. The anionic complex or TOPO adducts greatly enhanced the extraction. The data were statistically analyzed and the equilibrium constants for the extraction of these species, as well as the constants for the association of the HA, the A - tba + , or the TOPO on the MA 3 in the organic phase, were determined. The extraction of the MA 3 is better in the order LaA 3 3 3 . Although the values of the association constant of the HA or the TOPO on the MA 3 are rather similar for the three metal chelates, the constants for A - tba + are larger in the same order as mentioned above. Thus, the separation of these three metal ions by solvent extraction with this chelating extractant is not much affected by the addition of TOPO, but is greatly improved by the addition of tba + . (author)
33 CFR 150.612 - What footwear is required?
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What footwear is required? 150... footwear is required? The deepwater port operator must ensure that while personnel are working in an area... footwear that complies with 29 CFR 1910.136, except for when environmental conditions exist that present a...
Naturally enhanced ion-line spectra around the equatorial 150-km region
Directory of Open Access Journals (Sweden)
J. L. Chau
2009-03-01
Full Text Available For many years strong radar echoes coming from 140–170 km altitudes at low latitudes have been associated to the existence of field-aligned irregularities (FAIs (the so called 150-km echoes. In this work, we present frequency spectra as well as angular distribution of 150-km echoes. When the 150-km region is observed with beams perpendicular to the magnetic field (B the observed radar spectra are very narrow with spectral widths between 3–12 m/s. On the other hand, when few-degrees off-perpendicular beams are used, the radar spectra are wide with spectral widths comparable to those expected from ion-acoustic waves at these altitudes (>1000 m/s. Moreover the off-perpendicular spectral width increases with increasing altitude. The strength of the received echoes is one to two orders of magnitude stronger than the expected level of waves in thermal equilibrium at these altitudes. Such enhancement is not due to an increase in electron density. Except for the enhancement in power, the spectra characteristics of off-perpendicular and perpendicular echoes are in reasonable agreement with expected incoherent scatter spectra at these angles and altitudes. 150-km echoes are usually observed in narrow layers (2 to 5. Bistatic common volume observations as well as observations made few kilometers apart show that, for most of the layers, there is very high correlation on power fluctuations without a noticeable time separation between simultaneous echoes observed with Off-perpendicular and Perpendicular beams. However, in one of the central layers, the echoes are the strongest in the perpendicular beam and absent or very weak in the off-perpendicular beams, suggesting that they are generated by a plasma instability. Our results indicate that most echoes around 150-km region are not as aspect sensitive as originally thought, and they come from waves that have been enhanced above waves in thermal equilibrium.
Naturally enhanced ion-line spectra around the equatorial 150-km region
Directory of Open Access Journals (Sweden)
J. L. Chau
2009-03-01
Full Text Available For many years strong radar echoes coming from 140–170 km altitudes at low latitudes have been associated to the existence of field-aligned irregularities (FAIs (the so called 150-km echoes. In this work, we present frequency spectra as well as angular distribution of 150-km echoes. When the 150-km region is observed with beams perpendicular to the magnetic field (B the observed radar spectra are very narrow with spectral widths between 3–12 m/s. On the other hand, when few-degrees off-perpendicular beams are used, the radar spectra are wide with spectral widths comparable to those expected from ion-acoustic waves at these altitudes (>1000 m/s. Moreover the off-perpendicular spectral width increases with increasing altitude. The strength of the received echoes is one to two orders of magnitude stronger than the expected level of waves in thermal equilibrium at these altitudes. Such enhancement is not due to an increase in electron density. Except for the enhancement in power, the spectra characteristics of off-perpendicular and perpendicular echoes are in reasonable agreement with expected incoherent scatter spectra at these angles and altitudes. 150-km echoes are usually observed in narrow layers (2 to 5. Bistatic common volume observations as well as observations made few kilometers apart show that, for most of the layers, there is very high correlation on power fluctuations without a noticeable time separation between simultaneous echoes observed with Off-perpendicular and Perpendicular beams. However, in one of the central layers, the echoes are the strongest in the perpendicular beam and absent or very weak in the off-perpendicular beams, suggesting that they are generated by a plasma instability. Our results indicate that most echoes around 150-km region are not as aspect sensitive as originally thought, and they come from waves that have been enhanced above waves in thermal equilibrium.
Eugen Bleuler 150: Bleuler's reception of Freud.
Dalzell, Thomas G
2007-12-01
On the 150th anniversary of Eugen Bleuler's birth, this article examines his reception of Sigmund Freud and his use of Freudian theory to understand the symptoms of schizophrenia. In addition, in contrast to earlier interpretations of Bleuler's relationship with Freud in terms of an eventual personal and theoretical incompatibility, the article demonstrates that, although Bleuler did distance himself from the psychoanalytic movement, he remained consistent in his views on Freud's theories.
Reedsport PB150 Deployment and Ocean Test Project
Energy Technology Data Exchange (ETDEWEB)
Hart, Phil [Ocean Power Technologies Inc., Pennington, NJ (United States)
2016-06-03
As the first utility scale wave power project in the US, the Wave Power Demonstration Project at Reedsport (OR) was planned to consist of 10 PowerBuoys (Phase II)1, located 2.5 miles off the coast. U.S. Department of Energy (DOE) funding under a prior DOE Grant (DE-FG36-08GO88017) along with funding from PNGC Power, an Oregon-based electric power cooperative, was utilized for the design completion, fabrication, assembly and factory testing of the first PowerBuoy for the Reedsport project. The design and fabrication of the first PowerBuoy and factory testing of the power take-off subsystem were completed, and the power take-off subsystem was successfully integrated into the spar at the fabricator’s facility in Oregon. The objectives of this follow-on grant were: advance PB150B design from TRL 5/6 to TRL 7/8; deploy a single PB150 and operate autonomously for 2 years; establish O&M costs; collect environmental information; and establish manufacturing methodologies.
29 CFR 780.150 - Scope and limits of “preparation for market.”
2010-07-01
... 29 Labor 3 2010-07-01 2010-07-01 false Scope and limits of âpreparation for market.â 780.150... STANDARDS ACT General Scope of Agriculture Preparation for Market § 780.150 Scope and limits of “preparation for market.” “Preparation for market” is also named as one of the practices which may be included in...
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.
Singer, Rachel; Mawson, Paul; Derby, Nina; Rodriguez, Aixa; Kizima, Larisa; Menon, Radhika; Goldman, Daniel; Kenney, Jessica; Aravantinou, Meropi; Seidor, Samantha; Gettie, Agegnehu; Blanchard, James; Piatak, Michael; Lifson, Jeffrey D; Fernández-Romero, José A; Robbiani, Melissa; Zydowsky, Thomas M
2012-09-05
Microbicides may prevent HIV and sexually transmitted infections (STIs) in women; however, determining the optimal means of delivery of active pharmaceutical ingredients remains a major challenge. We previously demonstrated that a vaginal gel containing the non-nucleoside reverse transcriptase inhibitor MIV-150 partially protected macaques from SHIV-RT (simian/HIV reverse transcriptase) infection, and the addition of zinc acetate rendered the gel significantly protective. We test the activity of MIV-150 without the addition of zinc acetate when delivered from either ethylene vinyl acetate (EVA) or silicone intravaginal rings (IVRs). MIV-150 was successfully delivered, because it was detected in vaginal fluids and tissues by radioimmunoassay in pharmacokinetic studies. Moreover, EVA IVRs significantly protected macaques from SHIV-RT infection. Our results demonstrate that MIV-150-containing IVRs have the potential to prevent HIV infection and highlight the possible use of IVRs for delivering drugs that block HIV and other STIs.
Bioequivalence of fixed-dose combination RIN®-150 to each reference drug in loose combination.
Wang, H F; Wang, R; O'Gorman, M; Crownover, P; Damle, B
2015-03-01
RIN(®)-150 is a fixed-dose combination (FDC) tablet containing rifampicin (RMP, 150 mg) and isoniazid (INH, 75 mg) developed for the treatment of tuberculosis. This study was conducted at a single center: the Pfizer Clinical Research Unit in Singapore. To demonstrate bioequivalence of each drug component between RIN-150 and individual products in a loose combination. This was a randomized, open-label, single-dose, two-way crossover study. Subjects received single doses of RIN-150 or two individual reference products under fasting conditions in a crossover fashion, with at least 7 days washout between doses. The primary measures for comparison were peak plasma concentration (Cmax) and the area under plasma concentration-time curve (AUC). Of 28 subjects enrolled, 26 completed the study. The adjusted geometric mean ratios of Cmax and AUClast between the FDC and single-drug references and 90% confidence intervals were respectively 91.63% (90%CI 83.13-101.01) and 95.45% (90%CI 92.07-98.94) for RMP, and 107.58% (90%CI 96.07-120.47) and 103.45% (90%CI 99.33-107.75) for INH. Both formulations were generally well tolerated in this study. The RIN-150 FDC tablet formulation is bioequivalent to the two single-drug references for RMP and INH at equivalent doses.
Carter : Iisraelil on 150 või enam tuumapommi / Kaivo Kopli
Kopli, Kaivo
2008-01-01
USA endine president Jimmy Carter väitis, et Iisraelil on 150 tuumapommi või rohkemgi. Eri hinnangutest Iisraeli tuumapommide arvu kohta, n.-ö. tunnustatud tuumariigid maailmas. Lisa: Tuumakatsetus 1979. aastal?
2010-07-01
... and examine lifeboat and rescue boat launching appliances? 150.504 Section 150.504 Navigation and...: OPERATIONS Emergency and Specialty Equipment Launching Appliances § 150.504 When must the operator service and examine lifeboat and rescue boat launching appliances? (a) The operator must service launching...
Post-void residual urine under 150 ml does not exclude voiding dysfunction in women
DEFF Research Database (Denmark)
Khayyami, Yasmine; Klarskov, Niels; Lose, Gunnar
2016-01-01
INTRODUCTION AND HYPOTHESIS: It has been claimed that post-void residual urine (PVR) below 150 ml rules out voiding dysfunction in women with stress urinary incontinence (SUI) and provides license to perform sling surgery. The cut-off of 150 ml seems arbitrary, not evidence-based, and so we sough...
Preliminary results from a study of the double beta decay of 150Nd
International Nuclear Information System (INIS)
Perillo, I.M.C.; Chan, Y.D.; Hurley, D.; Lesko, K.T.; McDonald, R.J.; Moorhead, M.E.; Norman, E.B.; Smith, A.R.; Stokstad, R.G.
1996-01-01
We report the preliminary results from a study of the double beta decay of 150 Nd to the first 0 + excited state of 150 Sm. Our data consists of 50 days of counting 5 kg of natural Nd 2 O 3 at the LBNL-Oroville low background facility. The deduced lower limit for the half life of this decay mode is 4.9.10 19 years. (orig.)
Directory of Open Access Journals (Sweden)
Davide Carati
2014-06-01
Full Text Available Aim of the study. Authors investigated first of all the time to onset of first relief of symptoms. Secondary measures included the time to overall relief of symptoms and the reoccurrence rate over the first 45 days after the first visit. Methods. A randomized, open-label, parallel study evaluated 47 women with moderate to severe symptoms of Vulvo Vaginal Candidiasis (VVC. Patients were divided into two groups of treatment: group 1 followed a therapy with Fluconazole 150 mg tablets, while group 2 had a therapy based on Fluconazole 150 mg tablets coadjuvated by Dermoxen Lenitiva cream. Results. The time at which 50% of patients experienced first relief of symptoms was 24.6 hours for Group 1, while for Group 2 it was 12.4 hours (P<0.05. There were significant differences between the two groups in respect to the time of first relief of symptoms and reoccurrence of infection within 45 days of treatment. Conclusions. Combined treatment with Fluconazole 150 mg tablets and by Dermoxen Lenitiva cream provides statistically significant improvement in the time of first relief of symptoms, complete relief of symptoms and relapse time in the treatment of VVC compared to fluconazole 150 mg tablets only.
13 CFR 108.150 - Management and ownership diversity requirement.
2010-01-01
... VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.150... 70 percent of your Regulatory Capital or your Leverageable Capital. (c) Non-affiliation requirement. At least 30 percent of your Regulatory Capital and Leverageable Capital must be owned and controlled...
Directory of Open Access Journals (Sweden)
Dan-dan Xu
2016-11-01
Full Text Available Proliferation, a key feature of cancer cells, accounts for the majority of cancer-related diseases resulting in mortality. MicroRNAs (miRNAs plays important post-transcriptional modulation roles by acting on multiple signaling pathways, but the underlying mechanism in proliferation and tumorigenicity is unclear. Here, we identified the role of miR-150 in proliferation and tumorigenicity in leukemia stem cells (LSCs (CD34+CD38- cells. miR-150 expression was significantly down-regulated in LSCs from leukemia cell lines and clinical samples. Functional assays demonstrated that increased miR-150 expression inhibited proliferation and clonal and clonogenic growth, enhanced chemosensitivity, and attenuated tumorigenic activity of LSCs in vitro. Transplantation animal studies revealed that miR-150 overexpression progressively abrogates tumour growth. Immunohistochemistry assays demonstrated that miR-150 overexpression enhanced caspase-3 level and reduced Ki-67 level. Moreover, luciferase reporter assays indicated Nanog is a direct and functional target of miR-150. Nanog silencing using small interfering RNA recapitulated anti-proliferation and tumorigenicity inhibition effects. Furthermore, miR-150 directly down-regulated the expression of other cancer stem cell factors including Notch2 and CTNNB1. These results provide insights into the specific biological behaviour of miR-150 in regulating LSC proliferation and tumorigenicity. Targeting this miR-150/Nanog axis would be a helpful therapeutic strategy to treat acute myeloid leukemia.
Wang, N; Morra, M; Wu, C; Gullo, C; Howie, D; Coyle, T; Engel, P; Terhorst, C
2001-07-01
Human CD150 (SLAM) is a glycoprotein expressed on the surface of T, B, natural killer, and dendritic cells. The extracellular domain of CD150 is the receptor for measles virus and CD150 acts as a co-activator on T and B cells. We characterized the mouse and human CD150 genes, each of which comprises seven exons spanning approximately 32 kb. Mouse CD150 mRNA was detected in T cells and in most thymocyte subsets, except CD4-8- cells. Surprisingly, the CD4-8- thymocytes of CD3gammadeltanull mice, but not of Ragnull or severe combined immunodeficiency mice, expressed CD150. Whereas high levels of CD150 were found in Th1 cells, only small amounts were detectable in Th2 cells. CD150 expression was up-regulated upon in vitro activation of mouse T cells by anti-CD3. The complete mouse CD150 gene is highly homologous to its human orthologue in terms of nucleotide sequences and intron/exon organization. The human genomic sequences indicate that all isoforms detected so far have arisen from alternative splicing events. As judged by fluorescence in situ hybridization, mouse CD150 mapped to Chromosome (Chr) 1, band 1H2.2-2.3, and human CD150 was found on Chr 1q22. Human and mouse CD150 share sequence homologies with six other genes, five of which - CD84, CD229 (Ly-9), CD244 (2B4), CD48, and 19A - are localized in a 250-kb segment in close proximity to the human gene. Their location and their sequence similarities strongly suggest that the CD150 family of cell surface receptors arose via successive duplications of a common ancestral gene.
2010-01-01
... of personal securities trading transactions? 551.150 Section 551.150 Banks and Banking OFFICE OF... TRANSACTIONS Securities Trading Policies and Procedures § 551.150 How do my officers and employees file reports of personal securities trading transactions? An officer or employee described in § 551.140(d) must...
The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci
International Nuclear Information System (INIS)
Uwada, Junsuke; Tanaka, Niina; Yamaguchi, Yutaro; Uchimura, Yasuhiro; Shibahara, Kei-ichi; Nakao, Mitsuyoshi; Saitoh, Hisato
2010-01-01
The small ubiquitin-related modifier 2/3 (SUMO2/3) can be post-translationally conjugated to a wide variety of proteins constituting chromatin, the platform for genetic and epigenetic regulation. Nevertheless, it is unclear how SUMO2/3 and SUMO2/3-modified proteins are delivered to the chromatin fibers. Here we report that the largest subunit of chromatin assembly factor 1 (CAF-1), human p150, interacts directly and preferentially with SUMO2/3. Amino acid residue of 98-105 in p150 is essential and sufficient for SUMO2/3 interaction. p150-SUMO2/3 interaction coincided with regions that replicate chromatin fibers, because accumulation of the proliferating cell nuclear antigen (PCNA), and incorporation of bromodeoxyuridine (BrdU) were detected at foci co-localized with both p150 and SUMO2/3 during the S-phase in a cell line expressing epitope-tagged p150. Although inhibition of SUMO2/3 expression had only a small effect on p150 deposition on the replication sites, depletion of p150 led to delocalization of SUMO2/3 from the replication foci. Furthermore, p150 mutants deficient in SUMO2/3 interaction, caused a major reduction of SUMO2/3 at the replication foci. Thus, our findings suggest an expanded role of p150 as a SUMO2/3-interacting factor, and raise the intriguing possibility that p150 plays a role in promoting delivery of SUMO2/3 or SUMO2/3-modified proteins (or both) on chromatin fibers during replication.
150 years of Freud-Kraepelin dualism.
Trede, Katharina
2007-09-01
The year 2006 marked the 150th Birthday of Emil Kraepelin and Sigmund Freud. Kraepelin and Freud were two very different yet very similar men. The comparison between their biographies shows many parallels in their lives and personalities. They were, in their time, the two most influential individuals in psychiatry. They wrote and thought about similar topics in the field yet came to quite different conclusions. Both did not show public respect for each other but wrote about the importance of integrating their respective approaches into the study of the mind/brain problem. Psychiatry today continues to struggle with the integration of the biological and psychodynamic approach.
Superdeformation studies in {sup 150}Tb and {sup 153}Ho
Energy Technology Data Exchange (ETDEWEB)
Nisius, D.; Janssens, R.V.F.; Crowell, B. [and others
1995-08-01
There are now over 40 superdeformed (SD) bands known in the A {approximately} 150 region and in most cases the properties of these bands are understood in terms of single-particle excitations in the absence of pairing. By continuing the search for new SD bands we hope to gain insight into (1) the ordering of the proton and neutron orbitals near the Fermi surface in the SD well, (2) the effects that the alignment of those orbitals has on the moments of inertia, and (3) the collective excitations in the SD well. For {sup 150}Tb, which is one proton and one neutron away from the SD doubly-magic nucleus {sup 152}Dy, it should be possible to study SD bands based on both proton and neutron hole excitations. By adding one proton to the {sup 152}Dy nucleus (i.e. {sup 153}Ho) proton excitations above the Z = 66 shell gap can be studied. These excitations are important as calculations suggested that the proton intruder orbital N = 7 might become occupied. Interactions between this orbital and a N = 5 level may result in softness towards octupole vibrations. High spin states in {sup 150}Th and {sup 153}Ho were populated using the {sup 124}Sn({sup 31}P,5n) and {sup 120}Sn({sup 37}Cl,4n) reactions, respectively. In both cases the early implementation phase of Gammasphere was used to detect the decay gamma rays and over 1 x 10{sup 9} triple and higher fold coincidence events were recorded. In {sup 150}Tb, the data analysis is complete and two new SD bands were identified. The fact that Im{sup (2)} moments of inertia are sensitive to the specific high-N intruder content of the SD bands was used to suggest configurations for the two new bands. A paper reporting these results is being prepared. For {sup 153}Ho, data analysis is still in its early stages.
A-150 plastic radiometric calorimeter for charged particles and other radiations
International Nuclear Information System (INIS)
McDonald, J.C.; Domen, S.R.
1986-01-01
A local absorbed dose calorimeter with certain novel features has been designed and constructed of A-150 tissue-equivalent (TE) plastic. The radiation absorption properties of this material and the relative absence of core impurities make the calorimeter suitable for use in a wide variety of radiation beams. The low thermal diffusivity of A-150 plastic led to the development of a unique spiral electrical calibration heater that has a mass of only 0.1% that of the core. The calorimeter can be calibrated in the quasiadiabatic or the heat-loss-compensated mode to test for possible effects caused by temperature gradients. The details of construction and operation are described. (orig.)
14 CFR 1260.150 - Purpose of reports and records.
2010-01-01
... Purpose of reports and records. Sections 1260.151 through 1260.153 set forth the procedures for monitoring and reporting on the recipient's financial and program performance and the necessary standard... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Purpose of reports and records. 1260.150...
33 CFR 150.815 - How must casualties be reported?
2010-07-01
..., gas freeing, dry-docking, or demurrage of the port, vessel, or aircraft. (b) The notice under... (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Reports and Records Reports § 150.815 How must..., operator, or person in charge of a deepwater port must notify the nearest Sector, Marine Safety Unit, or...
The 150 Credit-Hour Requirement and CPA Examination Pass Rates--A Four Year Study
Briggs, Gary P.; He, Lerong
2012-01-01
Debate concerning the minimum educational requirements of certified public accountant (CPA) candidates in the USA has been taking place for decades. This paper compares the sectional pass rates of CPA candidates from jurisdictions requiring 150 credit hours of college study with the pass rates of candidates from jurisdictions not requiring 150…
The 150 ns detector project: Prototype preamplifier results
Warburton, W. K.; Russell, S. R.; Kleinfelder, Stuart A.
1994-08-01
The long-term goal of the 150 ns detector project is to develop a pixel area detector capable of 6 MHz frame rates (150 ns/frame). Our milestones toward this goal are: a single pixel, 1×256 1D and 8×8 2D detectors, 256×256 2D detectors and, finally, 1024 × 1024 2D detectors. The design strategy is to supply a complete electronics chain (resetting preamp, selectable gain amplifier, analog-to-digital converter (ADC), and memory) for each pixel. In the final detectors these will all be custom integrated circuits. The front-end preamplifiers are integrated first, since their design and performance are the most unusual and also critical to the project's success. Similarly, our early work is concentrated on devising and perfecting detector structures. In this paper we demonstrate the performance of prototypes of our integrated preamplifiers. While the final design will have 64 preamps to a chip, including a switchable gain stage, the prototypes were integrated 8 channels to a "Tiny Chip" and tested in 4 configurations (feedback capacitor Cf equal 2.5 or 4.0 pF, output directly or through a source follower). These devices have been tested thoroughly for reset settling times, gain, linearity, and electronic noise. They generally work as designed, being fast enough to easily integrate detector charge, settle, and reset in 150 ns. Gain and linearity appear to be acceptable. Current values of electronic noise, in double-sampling mode, are about twice the design goal of {2}/{3} of a single photon at 6 keV. We expect this figure to improve with the addition of the onboard amplifier stage and improved packaging. Our next test chip will include these improvements and allow testing with our first detector samples, which will be 1×256 (50 μm wide pixels) and 8×8 (1 mm 2 pixels) element detector on 1 mm thick silicon.
Siemens meelitab Eestisse 150 töökohta / Raigo Neudorf
Neudorf, Raigo
2002-01-01
Saksamaa elektroonikafirma Siemens tütarfirma Eestis võistleb selle eest, et tuua Eestisse emafirma 150 pakutavat töökohta majandustarkvara koostavatele spetsialistidele. Tabelid: Siemens Grupp Eesti tähtsamad majandusnäitajad. Siemensi kontsern
21 CFR 1271.150 - Current good tissue practice requirements.
2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Current good tissue practice requirements. 1271... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.150 Current good tissue practice requirements. (a) General. This subpart D and subpart C of this part set...
Applications of Flexible Ultrasonic Transducer Array for Defect Detection at 150 °C
Directory of Open Access Journals (Sweden)
Jiunn-Woei Liaw
2013-01-01
Full Text Available In this study, the feasibility of using a one dimensional 16-element flexible ultrasonic transducer (FUT array for nondestructive testing at 150 °C is demonstrated. The FUT arrays were made by a sol-gel sprayed piezoelectric film technology; a PZT composite film was sprayed on a titanium foil of 75 µm thickness. Since the FUT array is flexible, it was attached to a steel pipe with an outer diameter of 89 mm and a wall thickness of 6.5 mm at 150 °C. Using the ultrasonic pulse-echo mode, pipe thickness measurements could be performed. Moreover, using the ultrasonic pulse-echo and pitch-catch modes of each element of FUT array, the defect detection was performed on an Al alloy block of 30 mm thickness with a side-drilled hole (SDH of f3 mm at 150 °C. In addition, a post-processing algorithm based on the total focusing method was used to process the full matrix of these A-scan signals of each single transmitter and multi-receivers, and then the phase-array image was obtained to indicate this defect- SDH. Both results show the capability of FUT array being operated at 150 °C for the corrosion and defect detections.
33 CFR 150.531 - How many fire pumps must be kept ready for use at all times?
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false How many fire pumps must be kept ready for use at all times? 150.531 Section 150.531 Navigation and Navigable Waters COAST GUARD... Specialty Equipment Miscellaneous Operations § 150.531 How many fire pumps must be kept ready for use at all...
Milestones in 150 years of the chemical industry
International Nuclear Information System (INIS)
Morris, P.J.T.; Campbell, W.A.; Roberts, H.L.
1991-01-01
Milestones in 150 years of the Chemical Industry charts the history of the industry in its crucial role of meetings basic human needs. The book provides on overview of developments in the industry in the fields of health, clothing, energy, materials and information technology and sets the information in an historical context. It will be of interest to chemists in industry, academic, business and to the lay public. (author)
13 CFR 120.150 - What are SBA's lending criteria?
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are SBA's lending criteria... Policies Applying to All Business Loans Credit Criteria for Sba Loans § 120.150 What are SBA's lending... depth of management; (c) Strength of the business; (d) Past earnings, projected cash flow, and future...
The 150 kV cp microfocus X-ray unit
Fontijn, L.A.
1979-01-01
Development of microfocus X-ray technique is defined. Advantages on other methods, principle of operation and the material comprising an intense electron source imaged on an X-ray target by means of a double magnetic lense system, are described. Resolution value at 150 kV is the imaging of a 0.1 mm
Directory of Open Access Journals (Sweden)
Ivan Rattray
Full Text Available A variety of mouse models have been developed that express mutant huntingtin (mHTT leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated a slower striatal growth with a significant difference between wild type (WT and HdhQ150 mice being present even at 15 weeks. Indeed, MRI indicated significant volumetric changes prior to the emergence of the "clinical horizon" of motor impairments at 36 weeks of age. A striatal decrease of 27% was observed over 94 weeks with cortex (12% and hippocampus (21% also indicating significant atrophy. A hypothesis-free analysis using tensor-based morphometry highlighted further regions undergoing atrophy by contrasting brain growth and regional neurodegeneration. Histology revealed the widespread presence of mHTT aggregates and cellular inclusions. However, there was little evidence of correlations between these outcome measures, potentially indicating that other factors are important in the causal cascade linking the molecular pathology to the emergence of behavioral impairments. In conclusion, the HdhQ150 mouse model replicates many aspects of the human condition, including an extended pre-manifest period prior to the emergence of motor impairments.
150 Bulgarian students visit CERN
Alizée Dauvergne
2010-01-01
Between 27 March and 8 April 2010, 150 Bulgarian students from the Astronomical Observatory in Varna visited CERN as part of the “From Galileo to CERN” programme. Bulgarian students participating in the "From Galileo to CERN" educational programme. “It’s interesting to combine astronomy and particle physics”, explains Svejina Dimitrova, organiser of the programme and Director of Varna Astronomical Observatory. The three groups, each one comprising 50 students, first visited Pisa, Padua and other places in Italy related to Galileo’s life. “Thanks to the visit, students understood telescopes and why Galileo is such an important scientist”, says Svejina. After Italy, they came to CERN for three days and visited several sites: Linac, the Computer Centre CCC, etc. Another group of Bulgarian students in their visit to CERN. “They became aware that particle physics is not only the...
Adsorption gas chromatography with 150-ms {sup 216}Po
Energy Technology Data Exchange (ETDEWEB)
Vogt, A [Bern Univ. (Switzerland); Gaeggeler, H W; Tuerler, A [Paul Scherrer Inst. (PSI), Villigen (Switzerland)
1997-09-01
A gas chromatography apparatus was developed, which allows experiments with volatile radionuclides having shorter half-lives than one second. This apparatus was tested with the 150-ms isotope {sup 216}Po. Experimental data were compared with a Monte Carlo model to determine the adsorption enthalpy {Delta}H{sub a}. (author) 2 figs., 2 refs.
20 CFR 655.150 - Interstate clearance of job order.
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Interstate clearance of job order. 655.150... job order. (a) SWA posts in interstate clearance system. The SWA must promptly place the job order in... transmit a copy of its active job order to all States listed in the job order as anticipated worksites...
2010-04-01
...; detention; seizure or other disposition; blocked property. 12.150 Section 12.150 Customs Duties U.S. CUSTOMS...; detention; seizure or other disposition; blocked property. (a) Generally. Merchandise from certain countries... the United States shall be detained until the question of its release, seizure, or other disposition...
Recent experiments at Brookhaven: level structure of N = 86 isotones 156Yb and 150Gd
International Nuclear Information System (INIS)
Sunyar, A.W.
1980-01-01
States of the N = 86 isotones 156 Yb and 150 Gd have been studied by means of the 144 Sm( 16 O,4n) 156 Yb, 113 In( 46 Ti,p2n) 156 Yb, and 124 Sn( 30 Si,4n) 150 Gd reactions. Levels have been established to spin 36 h-bar and over 12.5 MeV in excitation in 150 Gd and to beyond spin 25 h-bar in 156 Yb. The systematics of levels in the N = 86 isotones from 150 Gd to 156 Yb are described, and the near-spherical shell model description for states in this region to near spin 30 h-bar is discussed. A T/sub 1/2/ = 6 ns, 72-keV isomeric transition in 156 Yb has been discovered, and an E1 multipolarity is assigned to this transition. The spin-parity of the isomeric state is established as 11 - . 6 figures
150 Years of Italian CO2 Emissions and Economic Growth
DEFF Research Database (Denmark)
Annicchiarico, Barbara; Bennato, Anna Rita; Chini, Emilio Zanetti
This paper examines the relationship between economic growth and carbon dioxide emissions in Italy considering the developments in a 150-year time span. Using several statistical techniques, we find that GDP growth and carbon dioxide emissions are strongly interrelated, with a dramatic change...
2016-07-01
The synthesized CNCs were optically very active and demonstrated very bright luminescence even under UV lamp excitation at room...temperature (Fig. 8.15). Fig. 8.16 shows absorption, Fig. 8.15. Visible luminescence from Pb3O2I2 under UV lamp excitation. M. Osiński, High-Performance Low...QCS - low-dimensional quantum confinement system LEDs – light-emitting diodes LuAG – lutetium aluminum garnet LYSO – lutetium yttrium
Budoff, Matthew J; Shinbane, Jerold S; Oudiz, Ronald J; Child, Janis; Carson, Sivi; Chau, Alex; Tseng, Philip; Gao, Yanlin; Mao, Songshou
2005-03-01
The newest generation of electron beam tomographic scanner (e-Speed) has increased spatial and temporal resolution compared with the C-150 XP scanner. The aim of this study was to evaluate coronary artery calcium screening image quality between the e-Speed and C-150 scanners (GE Imatron, San Francisco, CA). Studies from 41 patients (14 women and 27 men) who underwent serial coronary artery calcium screening with the C-150 (first study) and the e-Speed (second study) were analyzed. Individual computed tomography (CT) slices were assessed for coronary artery motion artifacts, and CT Hounsfield units (HU) and noise values (CT HU standard deviation) at 16 discrete cardiac sites were measured and averaged. With the e-Speed scanner, there were significant decreases in right coronary artery motion artifacts compared with the C-150 scanner (0.3% versus 1.8%, P Image quality is significantly improved with use of the e-Speed scanner, due to its improved temporal and spatial resolution, compared with the C-150 scanner.
46 CFR Table II to Part 150 - Grouping of Cargoes
2010-10-01
... solution Potassium oleate Potassium salt of polyolefin acid Propyl acetate Propylene carbonate Propylene... lignosulfonate solution Sodium polyacrylate solution 2 Sodium salt of Ferric hydroxyethylethylenediamine... 46 Shipping 5 2010-10-01 2010-10-01 false Grouping of Cargoes II Table II to Part 150 Shipping...
ORNL 150 keV neutral beam test facility
International Nuclear Information System (INIS)
Gardner, W.L.; Kim, J.; Menon, M.M.; Schilling, G.
1977-01-01
The 150 keV neutral beam test facility provides for the testing and development of neutral beam injectors and beam systems of the class that will be needed for the Tokamak Fusion Test Reactor (TFTR) and The Next Step (TNS). The test facility can simulate a complete beam line injection system and can provide a wide range of experimental operating conditions. Herein is offered a general description of the facility's capabilities and a discussion of present system performance
33 CFR 150.518 - What are the inspection requirements for work vests and immersion suits?
2010-07-01
... requirements for work vests and immersion suits? 150.518 Section 150.518 Navigation and Navigable Waters COAST... vests and immersion suits? (a) All work vests and immersion suits must be inspected by the owner or... a work vest or immersion suit is inspected and is in serviceable condition, then it may remain in...
33 CFR 150.20 - How many copies of the operations manual must be given to the Coast Guard?
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false How many copies of the operations manual must be given to the Coast Guard? 150.20 Section 150.20 Navigation and Navigable Waters COAST... § 150.20 How many copies of the operations manual must be given to the Coast Guard? The draft operations...
International Nuclear Information System (INIS)
Pujatti, Priscilla Brunelli
2009-01-01
Bombesin (BBN) receptors - in particular, the gastrin-releasing peptide (GRP) receptor peptide - have been shown to be massively over expressed in several human tumors types, including prostate cancer, and could be an alternative as target for its treatment by radionuclide therapy (RNT). A large number of BBN analogs had already been synthesized for this purpose and have shown to reduce tumor growth in mice. Nevertheless, most of the studied analogs exhibit high abdominal accumulation, especially in pancreas. This abdominal accumulation may represent a problem in clinical use of radiolabeled bombesin analogs probably due to serious side effects to patients. The goal of the present work was to radiolabel a novel series of bombesin derivatives with lutetium-177 and to evaluate the relationship between their structure and diagnostic-therapeutic activity for prostate tumor. The generic structure of studied peptides is DOTA-Phe-(Gly) n -BBN(6-14), where DOTA is the chelator, n is the number of glycine amino acids of Phe-(Gly) n spacer and BBN(6-14) is the bombesin sequence from the amino acid 6 to the amino acid 14. Preliminary studies were done to establish the ideal labeling conditions for obtaining the highest yield of labeled bombesin derivatives, determined by instant thin layer chromatography (ITLC-SG) and high performance liquid chromatography (HPLC). The stability of the preparations was evaluated either after storing at 2-8 degree C or incubation in human serum at 37 degree C and the partition coefficient was determined in n:octanol:water. In vivo studies were performed in both healthy Balb-c and Nude mice bearing PC-3 xenografts, in order to characterize the biological properties of labeled peptides. In vitro studies involved the evaluation of cold bombesin derivatives effect in PC-3 cells proliferation. Bombesin derivatives were successfully labeled with high yield at optimized conditions and exhibited high stability at 4 degree C. The analysis of the
7 CFR 929.150 - Transfer or assignment of sales history.
2010-01-01
... 7 Agriculture 8 2010-01-01 2010-01-01 false Transfer or assignment of sales history. 929.150... MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE... Transfer or assignment of sales history. (a) If indebtedness is incurred with regard to the acreage to...
‘Praise beyond Words’: Psalm 150 as grand finale of the crescendo in the Psalter
Directory of Open Access Journals (Sweden)
Dirk J. Human
2011-04-01
Full Text Available Without doubt the final hymn of the Psalter can be described as the climax, or grand finale, of the Israelite faith’s most known hymnbook. In this psalm, sound and action are blended into a picture of ecstatic joy. The whole universe is called upon to magnify Yah(weh, the God of Israel. The text poses various exegetical challenges. In the past, Psalm 150 was traditionally analysed as a single text; but with the advent of the canonical and redactionhistorical approaches to the interpretation of the Book of Psalms, Psalm 150 can be interpreted as part of the final Hallel (Pss 146–150, or Book V (Pss 107–150 of the Psalter. This view opens up new possibilities for reading the psalm in broader contexts and its broader literary context(s illuminate its theological significance. This article is an attempt at reflecting on the psalm’s context(s, structure, Gattung and dates of origin, tradition-historical relations to the Pentateuch, Psalms and other Old Testament texts. Ultimately some reflections on the psalm’s theological significance will be suggested.
Directory of Open Access Journals (Sweden)
Hussam E Salhi
2016-12-01
Full Text Available Troponin I (TnI is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit an expected or unexpected functional integration, whereby the function of two phosphorylations are different than that predicted from the combined function of each individual phosphorylation alone. We have shown that TnI Ser-23/24 and Ser-150 phosphorylation exhibit functional integration and are simultaneously increased in response to cardiac stress. In the current study, we investigated the functional integration of TnI Ser-23/24 and Ser-150 to alter cardiac contraction. We hypothesized that Ser-23/24 and Ser-150 phosphorylation each utilize distinct molecular mechanisms to alter the TnI binding affinity within the thin filament. Mathematical modeling predicts that Ser-23/24 and Ser-150 phosphorylation affect different TnI affinities within the thin filament to distinctly alter the Ca2+-binding properties of troponin. Protein binding experiments validate this assertion by demonstrating pseudo-phosphorylated Ser-150 decreases the affinity of isolated TnI for actin, whereas Ser-23/24 pseudo-phosphorylation is not different from unphosphorylated. Thus, our data supports that TnI Ser-23/24 affects TnI-TnC binding, while Ser-150 phosphorylation alters TnI-actin binding. By measuring force development in troponin-exchanged skinned myocytes, we demonstrate that the Ca2+ sensitivity of force is directly related to the amount of phosphate present on TnI. Furthermore, we demonstrate that Ser-150 pseudo-phosphorylation blunts Ser-23/24-mediated decreased Ca2+-sensitive force development whether on the same or different TnI molecule. Therefore, TnI phosphorylations can integrate across troponins along the myofilament. These data demonstrate
2012-06-27
... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Advisory Circular (AC) 150/5345-53D... Advisory Circular (AC) 150/5345-53D, Airport Lighting Equipment Certification Program, is being circulated... on a separate document and not embedded in the draft AC. Additionally, please provide justification...
Design of the free-air ionization chamber, FAC-IR-150, for X-ray dosimetry
Mohammadi, Seyed Mostafa; Tavakoli-Anbaran, Hossein
2018-03-01
The primary standard for X-ray dosimetry is based on the free-air ionization chamber (FAC). Therefore, the Atomic Energy Organization of Iran (AEOI) designed the free-air ionization chamber, FAC-IR-150, for low and medium energy X-ray dosimetry. The purpose of this work is the study of the free-air ionization chamber characteristics and the design of the FAC-IR-150. The FAC-IR-150 dosimeter has two parallel plates, a high voltage plate and a collector plate. A guard electrode surrounds the collector and is separated by an air gap. A group of guard strips is used between up and down electrodes to produce a uniform electric field in all the ion chamber volume. This design involves introducing the correction factors and determining the exact dimensions of the ionization chamber by using Monte Carlo simulation.
Oxidation of UO2 at 150 to 3500C
International Nuclear Information System (INIS)
White, G.D.; Knox, C.A.; Gilbert, E.R.; Johnson, A.B. Jr.
1983-07-01
Oxidation of UO 2 through breached LWR spent fuel rods during interim storage in air atmospheres is a potential mechanism for degradation of cladding integrity. The temperature-time range of published data are inadequate to establish long term behavior under dry storage conditions. Consequently, tests are being conducted in the temperature range of 150 to 350 0 C on unirradiated pellets to evaluate fuel oxidation behavior. The tests have revealed significant-to-minor oxidation at temperatures down to 200 0 C and no measurable oxidation at 150 0 C for times up to 3000 hours. Oxidation at 200 0 C for 2000 hours led to formation of low density particulate U 3 O 8 which destroys pellet integrity. Oxidation of UO 2 pellets at 215 and 250 0 C was signifcantly accelerated by the presence of 1 volume percent NO 2 in the air. NO 2 is a potential constituent of the air, forming by radiolysis in the gamma radiation field associated with spent fuel assemblies. NO 2 reaction with UO 2 pellets leads to accelerated formation of UO 3 and pellet disintegration. 11 references, 15 figures
41 CFR 102-192.150 - What are your general responsibilities as a program level mail manager?
2010-07-01
... responsibilities as a program level mail manager? 102-192.150 Section 102-192.150 Public Contracts and Property... general responsibilities as a program level mail manager? Your responsibilities at the program level include— (a) Working closely with the agency mail manager and mail center managers who handle significant...
TS-05: 150 lines of java with high architectural complexity
DEFF Research Database (Denmark)
Christensen, Henrik Bærbak
2005-01-01
In the short time span available in a software architecture course, it is difficult to find a software system that is both interesting from an architectural perspective and so small that it does not overwhelm the students.We present TS-05 which is a bare 150 line Java "toy-system" that never...
21 CFR 163.150 - Sweet cocoa and vegetable fat coating.
2010-04-01
... preparation of the product, cocoa or a mixture of cocoa and chocolate liquor is used in such quantity that the... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Sweet cocoa and vegetable fat coating. 163.150... (CONTINUED) FOOD FOR HUMAN CONSUMPTION CACAO PRODUCTS Requirements for Specific Standardized Cacao Products...
Redetermination of 3-methylisoquinoline at 150 K
Directory of Open Access Journals (Sweden)
Andrew D. Bond
2010-11-01
Full Text Available The structure of the title compound, C19H9O, has been redetermined at 150 K. The redetermination is of significantly higher precision than a previous room-temperature structure [Ribar et al. (1974. Cryst. Struct. Commun. 3, 323–325]. The C—N bond lengths for this redetermination are much closer to those observed in comparable structures, and the orientation of the methyl group with respect to the isoquinoline plane is clarified. Intermolecular weak C—H...N contacts are present in the crystal.
33 CFR 150.503 - What are the time interval requirements for maintenance on survival craft falls?
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What are the time interval requirements for maintenance on survival craft falls? 150.503 Section 150.503 Navigation and Navigable Waters... maintenance on survival craft falls? (a) Each fall used in a launching device for survival craft or rescue...
MicroRNA-150 Is up-regulated in extranodal marginal zone lymphoma of MALT type.
Gebauer, Niklas; Kuba, Johannes; Senft, Andrea; Schillert, Arne; Bernard, Veronica; Thorns, Christoph
2014-01-01
The mechanisms promoting malignant transformation from chronic Helicobacter pylori-gastritis to gastric extranodal marginal zone lymphoma (MALT lymphoma) are insufficiently characterized. This follow-up study aimed to validate candidate microRNAs (miRs) in the process of neoplastic transformation. MicroRNA expression signatures (n=20) were generated for a total of 60 cases of gastric lesions ranging from Wotherspoon 0-5 employing a quantitative real-time polymerase chain reaction (PCR) approach. Morphological and immunohistochemical characterization of the cohort was supplemented by PCR-based immunoglobulin heavy chain recombination studies. Quantitative expression of miR-150, miR-142.3p, miR-375 and miR-494 was significantly de-regulated in samples from MALT lymphoma compared to those from gastritis. The previously reported up-regulation of miR-150 in marginal zone lymphoma of MALT type was verified in an independent cohort of lymphoma samples employing a modified methodology. This further substantiates the role of miR-150 as a potential oncomiR in MALT lymphoma.
2010-01-01
... fully cooked poultry products and partially cooked poultry breakfast strips. 381.150 Section 381.150... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Entry of Articles Into Official Establishments; Processing...
150 keV intense electron beam accelerator system with high repeated pulse
International Nuclear Information System (INIS)
Qi, Zhang; Tixing, Li; Hongfang, Tang; Nenggiao, Xia; Zhigin, Wang; Baohong, Zheng
1993-01-01
A 150 keV electron beam accelerator system has been developed for wide application of high power particle beams. The new wire-ion-plasma electron gun has been adopted. The parameters are as follows: Output energy - 130-150 keV; Electron beam density - 250 mA/cm 2 ; Pulse duration - 1 μs; Pulse rate 100 pps; Section of electron beam - 5 x 50 cm 2 . This equipment can be used to study repeated pulse CO 2 laser, to be a preionizer of high power discharge excimer laser and to perform radiation curing process, and so on. The first part contains principle and design consideration. Next is a description of experimental arrangement. The remainder is devoted to describing experimental results and its application
'Praise beyond Words': Psalm 150 as grand finale of the crescendo ...
African Journals Online (AJOL)
Test
2010-09-01
Sep 1, 2010 ... historical approaches to the interpretation of the Book of Psalms, Psalm 150 can be interpreted as part of the ..... as the climatic doxology of the final Hallel.16. Text and ...... rhythm and melody, or contact with the divine; they.
Experimental adaptation of wild-type canine distemper virus (CDV to the human entry receptor CD150.
Directory of Open Access Journals (Sweden)
Maria Bieringer
Full Text Available Canine distemper virus (CDV, a close relative of measles virus (MV, is widespread and well known for its broad host range. When the goal of measles eradication may be achieved, and when measles vaccination will be stopped, CDV might eventually cross the species barrier to humans and emerge as a new human pathogen. In order to get an impression how fast such alterations may occur, we characterized required adaptive mutations to the human entry receptors CD150 (SLAM and nectin-4 as first step to infect human target cells. Recombinant wild-type CDV-A75/17(red adapted quickly to growth in human H358 epithelial cells expressing human nectin-4. Sequencing of the viral attachment proteins (hemagglutinin, H, and fusion protein, F genes revealed that no adaptive alteration was required to utilize human nectin-4. In contrast, the virus replicated only to low titres (10(2 pfu/ml in Vero cells expressing human CD150 (Vero-hSLAM. After three passages using these cells virus was adapted to human CD150 and replicated to high titres (10(5 pfu/ml. Sequence analyses revealed that only one amino acid exchange in the H-protein at position 540 Asp→Gly (D540G was required for functional adaptation to human CD150. Structural modelling suggests that the adaptive mutation D540G in H reflects the sequence alteration from canine to human CD150 at position 70 and 71 from Pro to Leu (P70L and Gly to Glu (G71E, and compensates for the gain of a negative charge in the human CD150 molecule. Using this model system our data indicate that only a minimal alteration, in this case one adaptive mutation, is required for adaptation of CDV to the human entry receptors, and help to understand the molecular basis why this adaptive mutation occurs.
Prevalence of Complains and Rehabilitation Needs in 150 Patients
Ahmad Ali Akbari-Kamrani
2001-01-01
Objective: Many studies and researches have been done regarding elderly care health in countries with approved geriatrics as an independent branch. Because geriatrics is a new subject in Iran, this study was done in order to assess about social conditions and prevalence of elderly complaints and their rehabilitation services. Materials & Methods: This is a descriptive study. 150 elderly who were admitted ambulatory in the educational, research and rehabilitation center for older people in...
International Nuclear Information System (INIS)
Mohd Hadzley, A B; Wan Mohd Azahar, W M Y; Izamshah, R; Mohd Shahir, K; Mohd Amran, A; Anis Afuza, A
2016-01-01
This paper presents a study of development the tool life's mathematical model during the milling process on High Thermal Conductivity Steel 150 (HTCS-150) 56 HRC. Using response surface methodology, the mathematical models for tool life have been developed in terms of cutting speed, feed rate and depth of cut. Box-Behnken techniques is a part of Response Surface Methodology (RSM) has been used to carry out the work plan to predict, the tool wear and generate the numerical equation in relation to independent variable parameters by Design Expert software. Dry milling experiments were conducted by using two levels of cutting speed, feed rate and depth of cut. In this study, the variable for the cutting speed, feed rate and depth of cut were in the range of 484-553 m/min, 0.31-0.36 mm/tooth, and 0.1-0.5 mm, width of cut is constantly 0.01mm per passes. The tool wear was measured using tool maker microscope. The effect of input factors that on the responds were identified by using mean of ANOVA. The responds of tool wear then simultaneously optimized. The validation of the test reveals the model accuracy 5% and low tool wear under same experimental condition. (paper)
Mohd Hadzley, A. B.; Mohd Azahar, W. M. Y. Wan; Izamshah, R.; Mohd Shahir, K.; Mohd Amran, A.; Anis Afuza, A.
2016-02-01
This paper presents a study of development the tool life's mathematical model during the milling process on High Thermal Conductivity Steel 150 (HTCS-150) 56 HRC. Using response surface methodology, the mathematical models for tool life have been developed in terms of cutting speed, feed rate and depth of cut. Box-Behnken techniques is a part of Response Surface Methodology (RSM) has been used to carry out the work plan to predict, the tool wear and generate the numerical equation in relation to independent variable parameters by Design Expert software. Dry milling experiments were conducted by using two levels of cutting speed, feed rate and depth of cut. In this study, the variable for the cutting speed, feed rate and depth of cut were in the range of 484-553 m/min, 0.31-0.36 mm/tooth, and 0.1-0.5 mm, width of cut is constantly 0.01mm per passes. The tool wear was measured using tool maker microscope. The effect of input factors that on the responds were identified by using mean of ANOVA. The responds of tool wear then simultaneously optimized. The validation of the test reveals the model accuracy 5% and low tool wear under same experimental condition.
Numerical Investigation for the Plasma Coal Gasifier of 150kW and 1400kW
Energy Technology Data Exchange (ETDEWEB)
Choi, Hyeong Yeong; Suh, Jae Seung [Hannam University, Daejeon (Korea, Republic of); Lho, Tai Hyeop [National Fusion Research Institute, Daejeon (Korea, Republic of)
2016-05-15
This study has verification of simulation for the gasifier of 150kWe and focuses on prediction of performance for the gasifier of 1.4MWe with a computational fluid dynamics (CFD) method. It is possible to predict flow patterns, tracks of particles, combustion characteristics, temperature distributions and chemical distributions using the commercial CFD solver ANSYS/FLUENT. Integrated coal gasification combined cycle (IGCC) has gained a lot of interest because they can produce cleaner gaseous fuels such as hydrogen, carbon monoxide and methane. Therefore, the National Fusion Research Institute (NFRI) plant has been investigating the application of their plasma technology to gasify coal. It is a fusion plasma technology for better efficiency of low-carbon fuels. They recently completed experiment for the gasifier of 150kwe, and are currently trying experiment for the gasifier of 1.4MWe. They have tried to design the gasifier that has cold gases of a higher efficiency. However it is considerably complicated and expensive that performance of gasifier is experimentally studied, because it is difficult to measure or control gases of very high temperature. This study has numerical investigation for the phenomena of coal gasification for coal gasifier of 150kWe and 1.4MWe at experiment operating conditions. This study has verification of simulation for the gasifier of 150kWe, and predicts performance for the gasifier of 1.4MWe. The gasifier of 1.4MWe will have a cold gas of higher efficiency than gasifier of 150kWe because can generate many hydrogen gas. So this gasification has the potential to become cornerstone technology in many hydrogen industries.
33 CFR 150.515 - What are the requirements for weight testing of newly installed or relocated craft?
2010-07-01
... weight testing of newly installed or relocated craft? 150.515 Section 150.515 Navigation and Navigable... testing of newly installed or relocated craft? (a) The operator must perform installation weight testing... (a) of this section, when survival crafts are relocated to another deepwater port. ...
Young, Douglas; Mayer, Franziska; Vidotto, Nella; Schweizer, Tatjana; Berth, Ramon; Abramowski, Dorothee; Shimshek, Derya R.; van der Putten, P. Herman; Schmid, Peter
2013-01-01
Huntington's disease (HD) is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the huntingtin gene. The encoded poly-glutamine stretch renders mutant huntingtin prone to aggregation. HdhQ150 mice genocopy a pathogenic repeat (∼150 CAGs) in the endogenous mouse huntingtin gene and model predominantly pre-manifest HD. Treating early is likely important to prevent or delay HD, and HdhQ150 mice may be useful to assess therapeutic strategies targeting pre-manifest HD. This requires appropriate markers and here we demonstrate, that pre-symptomatic HdhQ150 mice show several dramatic mutant huntingtin gene-dose dependent pathological changes including: (i) an increase of neuronal intra-nuclear inclusions (NIIs) in brain, (ii) an increase of extra-nuclear aggregates in dentate gyrus, (iii) a decrease of DARPP32 protein and (iv) an increase in glial markers of neuroinflammation, which curiously did not correlate with local neuronal mutant huntingtin inclusion-burden. HdhQ150 mice developed NIIs also in all retinal neuron cell-types, demonstrating that retinal NIIs are not specific to human exon-1 R6 HD mouse models. Taken together, the striking and robust mutant huntingtin gene-dose related changes in aggregate-load, DARPP32 levels and glial activation markers should greatly facilitate future testing of therapeutic strategies in the HdhQ150 HD mouse model. PMID:24086450
Directory of Open Access Journals (Sweden)
Nedim Tuno
2015-12-01
Full Text Available Generalna karta Bosne i Hercegovine razmjere 1:150 000 u izdanju Vojnogeografskog instituta u Beču predstavlja jednu od najznačajnijih karata izrađenih na osnovu prvog sistematskog geodetskog premjera BiH. Temeljem analize izvornih kartografskih dokumenata i ostalih dostupnih podataka, u radu su izneseni najbitniji detalji koji karakterišu ovu kartu. Poslije kratkog historijskog osvrta na okolnosti koje su dovele do njenog nastanka, detaljno su analizirani elementi karte. Data je i kratka uporedba primijenjenih rješenja na spomenutoj karti s onima na ranijoj karti razmjere 1:300 000. Na osnovi provedenih istraživanja zaključuje se da je generalna karta BiH prva prava moderna topografska karta te zemlje, koja predstavlja izuzetno vrijednu kartografsku baštinu. : General map of Bosnia and Herzegovina at scale 1:150 000 published by the Military Geographical Institute of Vienna. is one of the most important maps made on the basis of the first systematic geodetic survey of B&H. Based on the analysis of the original cartographic documents and other available data, the paper presents the most important details that characterize this map. The elements of the map are analyzed in details after a brief historical review of the circumstances that led to the creation of the map. A brief comparison of solutions adopted on this map, with those of the previous 1: 300 000 scale map, is also given in the paper. Based on the conducted research it was concluded that the General map of Bosnia and Herzegovina is the first true modern topographic map of the country. This map is a cartographic heritage of exceptional value.
46 CFR 199.150 - Survival craft launching and recovery arrangements; general.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft launching and recovery arrangements... Vessels § 199.150 Survival craft launching and recovery arrangements; general. (a)(1) Each launching...) Unless expressly provided otherwise in this part, each survival craft must be provided with a launching...
46 CFR 133.150 - Survival craft launching and recovery arrangements: General.
2010-10-01
... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft launching and recovery arrangements...) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.150 Survival craft launching and recovery arrangements: General. (a) All survival craft required for abandonment by the total number of...
29 CFR 786.150 - Enforcement policy concerning performance of nonexempt work.
2010-07-01
... 29 Labor 3 2010-07-01 2010-07-01 false Enforcement policy concerning performance of nonexempt work..., DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS MISCELLANEOUS EXEMPTIONS Employers Subject to Part 1 of Interstate Commerce Act § 786.150 Enforcement policy...
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false After learning of a possible violation, what does the Officer in Charge of Marine Inspection do? 150.606 Section 150.606 Navigation and...: OPERATIONS Workplace Safety and Health Safety and Health (general) § 150.606 After learning of a possible...
International Nuclear Information System (INIS)
Pasztor, E.
1976-09-01
The description of the ion-implanter of 150 keV maximum energy designed and built in the Central Research Institute for Physics, Budapest is given. The implanter fulfils all technological and safety requirements of the industry. In addition to B,P and As other elements up to mass-number 76 can also be implanted by help of the Danfysik 911 type ion source. The 3x10 -6 Torr operational pressure is provided by three turbomolecular pumps. The maximum dose is 1 μCb/cm 2 min and to ensure uniformity of the implantation on the 100x105 mm 2 target area the ion beam is swept electrostatically. According to the testing experiments the inhomogenity can be taken to be +-1.3%. (Sz.N.Z.)
46 CFR Table I to Part 150 - Alphabetical List of Cargoes
2010-10-01
... cargo name), see Caustic potash solution 5 2 CPS Potassium oleate 34 POE Potassium salt of polyolefin... Sodium polyacrylate solution 43 2 Sodium salt of Ferric hydroxyethylethylenediaminetriacetic acid... 46 Shipping 5 2010-10-01 2010-10-01 false Alphabetical List of Cargoes I Table I to Part 150...
International Nuclear Information System (INIS)
Gong, Maoqiong; Cheng, Kuiwei; Dong, Xueqiang; Guo, Hao; Zhao, Yanxing; Wu, Jianfeng
2015-01-01
Highlights: • VLE data for (R13I1 + R152a) system were measured at four temperatures. • Experiments were based on the vapor-recirculation method. • VLE data were correlated using PR−VdWs and PR−HV−NRTL models. • Azeotropic behavior can be found. - Abstract: In this paper, isothermal (vapor + liquid) equilibrium (VLE) values for {trifluoroiodomethane (R13I1) + 1,1-difluoroethane (R152a)} at T = (258.150 to 283.150) K are presented. The experimental apparatus was based on a vapor-recirculation method. The VLE measurements were regressed by the Peng–Robinson equation of state with two models, the Van der Waals mixing rules and the Huron–Vidal mixing rules using the NRTL activity coefficient model. The newly measured VLE values satisfied the thermodynamic consistency test. The results have led to that the two models selected are both suitable for the description of the binary system. Azeotropic behavior can be found for the system measured
Prevalence of Complains and Rehabilitation Needs in 150 Patients
Directory of Open Access Journals (Sweden)
Ahmad Ali Akbari-Kamrani
2001-06-01
Full Text Available Objective: Many studies and researches have been done regarding elderly care health in countries with approved geriatrics as an independent branch. Because geriatrics is a new subject in Iran, this study was done in order to assess about social conditions and prevalence of elderly complaints and their rehabilitation services. Materials & Methods: This is a descriptive study. 150 elderly who were admitted ambulatory in the educational, research and rehabilitation center for older people in 1999, were assessed, and required information were taken. Results: 150 elderly patients assessed, 58% female, 42% male, minimum age: 55 years. Maximum age: 100 years, 17.3% were illiterate, 19.3% had college studies. In female group 13% were widows and in male group 1.2% were widowers. 2 women and 1 man had never married. Cardio pulmonary disorders were the most common complaints (63.3%, then musculoskeletal disorders (55.6%, psychological disturbances (24.6%, neurological disorders (18%, 35% of above cases received physiotherapy, 13% occupational therapy and 2% speech therapy. Conclusion: It seems that in our community, rehabilitation services are given less than the countries with approved geriatrics medicine. Perhaps the role of rehabilitation in the quality of elderly life, for both, patients and their physicians is ignored. It is suggested that, rehabilitation disciplinary must be introduced more than before to physicians, especially who are working in the field of geriatrics.
Ce2O3-SO3-H2O system at 150 and 200 deg C
International Nuclear Information System (INIS)
Belokoskov, V.I.; Trofimov, G.V.; Govorukhina, O.A.
1978-01-01
The solubility, solid phase composition and crystal characteristics in the Ce 2 O 3 -SO 3 -H 2 O system have been studied in a broad range of sulfuric acid concentrations (25 to 80% SO 3 ) at temperatures from 150 to 200 deg C. It has been established that in the system the equilibrium had been reached after 15 to 20 days. At 150 deg C, Ce 2 (SO 4 ) 3 x2H 2 O, Ce 2 (SO 4 ) 3 xH 2 O sulfates and Ce 2 (SO 4 ) 3 x3H 2 SO 4 acid salt crystallize in the system. At 200 deg C, the same sulfates crystallize in the system, except that the bisaturation points of the system are shifted, with respect to 150 deg C, into the region of higher SO 3 concentration and correspond to solutions with a SO 3 concentration of 57.8 and 65%. The solubility of cerium(3) at 150 deg C is about 0.5% Ce 2 O 3 . An increase in temperature up to 200 deg C leads to a slightly higher solubility of cerium sulfates
Zhuge, Baozhong; Li, Guohong
2017-12-16
The prevalence of Non-alcoholic fatty liver diseases (NAFLD) increased rapidly in the world. However, the pathogenesis of is still unclear. Hepatic steatosis and insulin resistance are considered to be central to the pathophysiology of NAFLD. MicroRNAs are short non-coding RNAs and has been reported to be involved in pathogenesis of NAFLD and related metabolic diseases. Here, we investigated the mechanisms by which miR-150 regulate hepatic steatosis and insulin resistance in high fat diet (HFD) induced NAFLD model. The expression of miR-150 was up-regulated dramatically in both human NAFLD patients and HFD mice model, as well as in hepatocytes treated with oleic acid. miR-150 deficiency ameliorated the hepatic steatosis and insulin resistance significantly in NAFLD mice. miR-150 deficiency decreased the expression of genes related to fatty acid uptake, synthesis and gluconeogenesis, while increased the expression of genes related to fatty acid β-oxidation. Further, we identified that CFLAR is a direct downstream target of miR-150. Overexpression of miR-150 reduced both the mRNA and protein levels of CFLAR in vitro. And overexpression of miR-150 significantly inhibited the luciferase activity of CFLAR 3'-UTR, while the effect of miR-150 was blocked when the binding site of miR-150 within the CFLAR 3'-UTR was mutated. We also found that miR-150 deficiency decreased the expression of p-Jnk1 and p-Ask1, while the effect of miR-150 on steatosis and insulin signaling was blocked by CFLAR overexpression. In conclusion, our data indicated that miR-150 potentially contributes to the hepatic steatosis and insulin resistance in NAFLD. miR-150/CFLAR pathway may be a new therapeutic strategy against NAFLD. Copyright © 2017 Elsevier Inc. All rights reserved.
International Nuclear Information System (INIS)
Pyartman, A.K.; Kovalev, S.V.; Keskinov, V.A.; Kopyrin, A.A.
1997-01-01
A study was made on extraction of nitrates of lanthanoids (3) of the yttrium group (terbium-lutetium) and yttrium (3) by trialkylbensylammonium nitrate in toluene at T=298.15 K pH 2. Extraction isotherms are described with account of formation of compound of (R 4 N) 2 [Ln(NO 3 ) 5 ] composition in organic phase. Values of extraction constants decreasing in terbium (3)-lutetium (3) series, were calculated. Value of extraction constant for yttrium (3) is close to the value of extraction constant for ytterbium (3). 13 refs., 2 figs., 3 tabs
Directory of Open Access Journals (Sweden)
László Hackler
Full Text Available C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 was mediated by affecting multiple targets as confirmed at transcription and protein level. C-150 effectively reduced the transcription activation of NFkB, inhibited PKC-alpha which are constitutively over-expressed in glioblastoma. The effects of C-150 on the Akt/ Notch signaling were also demonstrated in a Drosophila tumorigenesis model. C-150 reduced the number of tumors in Drosophila with similar efficacy to mitoxantrone. In an in vivo orthotopic glioma model, C-150 significantly increased the median survival of treated nude rats compared to control animals. The multi-target action of C-150, and its preliminary in vivo efficacy would render this curcumin analogue as a potent clinical candidate against glioblastoma.
21 CFR 333.150 - Labeling of first aid antibiotic drug products.
2010-04-01
... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Labeling of first aid antibiotic drug products... First Aid Antibiotic Drug Products § 333.150 Labeling of first aid antibiotic drug products. (a... identifies the product as a “first aid antibiotic.” (b) Indications. The labeling of the product states...
29 CFR 1952.150 - Description of the plan as initially approved.
2010-07-01
... Carolina § 1952.150 Description of the plan as initially approved. (a) The Department of Labor has been designated by the Governor of North Carolina to administer the plan throughout the State. The Department of... are not covered by the Federal act by virtue of section 4(b)(1) thereof, dockside maritime and...
Creation of Nuclear Data Base up to 150 MeV and corresponding scaling approach for ADS
International Nuclear Information System (INIS)
Shubin, Y. N.; Gai, E. V.; Ignatyuk, A. V.; Lunev, V. P.
1997-01-01
The status of nuclear data in the energy region up to 150 MeV is outlined. The specific physical reasons for the detailed investigations of nuclear structure effects is noted out. The necessity of the development of Nuclear Data System for ADS is stressed. The program for the creation of nuclear data base up to 150 MeV and corresponding scaling approach for ADS is proposed. (Author) 14 refs
Smith, Corey L; Matheson, Timothy D; Trombly, Daniel J; Sun, Xiaoming; Campeau, Eric; Han, Xuemei; Yates, John R; Kaufman, Paul D
2014-09-15
Chromatin assembly factor-1 (CAF-1) is a three-subunit protein complex conserved throughout eukaryotes that deposits histones during DNA synthesis. Here we present a novel role for the human p150 subunit in regulating nucleolar macromolecular interactions. Acute depletion of p150 causes redistribution of multiple nucleolar proteins and reduces nucleolar association with several repetitive element-containing loci. Of note, a point mutation in a SUMO-interacting motif (SIM) within p150 abolishes nucleolar associations, whereas PCNA or HP1 interaction sites within p150 are not required for these interactions. In addition, acute depletion of SUMO-2 or the SUMO E2 ligase Ubc9 reduces α-satellite DNA association with nucleoli. The nucleolar functions of p150 are separable from its interactions with the other subunits of the CAF-1 complex because an N-terminal fragment of p150 (p150N) that cannot interact with other CAF-1 subunits is sufficient for maintaining nucleolar chromosome and protein associations. Therefore these data define novel functions for a separable domain of the p150 protein, regulating protein and DNA interactions at the nucleolus. © 2014 Smith et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
Zonal asymmetry of daytime 150-km echoes observed by Equatorial Atmosphere Radar in Indonesia
Directory of Open Access Journals (Sweden)
T. Yokoyama
2009-03-01
Full Text Available Multi-beam observations of the daytime ionospheric E-region irregularities and the so-called 150-km echoes with the 47-MHz Equatorial Atmosphere Radar (EAR in West Sumatra, Indonesia (0.20° S, 100.32° E, 10.36° S dip latitude are presented. 150-km echoes have been frequently observed by the EAR, and their characteristics are basically the same as the equatorial ones, except for an intriguing zonal asymmetry; stronger echoes in lower altitudes in the east directions, and weaker echoes in higher altitudes in the west. The highest occurrence is seen at 5.7° east with respect to the magnetic meridian, and the altitude gradually increases as viewing from the east to west. Arc structures which return backscatter echoes are proposed to explain the asymmetry. While the strength of radar echoes below 105 km is uniform within the wide coverage of azimuthal directions, the upper E-region (105–120 km echoes also show a different type of zonal asymmetry, which should be generated by an essentially different mechanism from the lower E-region and 150-km echoes.
The collectivity and the de-excitation of the yrast superdeformed band in sup 150 Gd
Energy Technology Data Exchange (ETDEWEB)
Fallon, P.; Alderson, A.; Ali, I.; Cullen, D.M.; Forsyth, P.D.; Riley, M.A.; Roberts, J.W.; Sharpey-Schafer, J.F.; Twin, P.J. (Liverpool Univ. (UK). Oliver Lodge Lab.); Bentley, M.A.; Bruce, A.M. (Science and Engineering Research Council, Daresbury (UK). Daresbury Lab.)
1991-03-28
A Doppler shift attenuation measurement has been carried out to determine the collectivity of the superdeformed band in {sup 150}Gd. The data was found to be consistent with a constant inband quadrupole moment of 17+-3 eb. This corresponds to a quadrupole deformation of {beta}{sub 2}{approx equal}0.58. In addition the measurement has resolved important questions regarding the de-excitation of the band, confirming the rapid de-excitation of the superdeformed band in {sup 150}Gd with more than 80% of the band intensity being lost over one transition. (orig.).
150 keV accelerator as pulsed neutron source; Acelerador de 150 keV como fuente de neutrones pulsada
Energy Technology Data Exchange (ETDEWEB)
Cordero, F
1970-07-01
The project of a 150 keV Cockcroft-Walton accelerator built at J.E.N. is described. Beam currents of more than 10 mA, with a neutron intensity of 10{sup 1}1 n.s{sup 1}, are obtained. Also, we report some research made in connection with that project. The role of the contamination in the vacuum system and the performance of the pumps and gauges pumping deuterium gas are studied. Sinusoidal pulses are employed as an analysis method of the discharge in the ion source and the performance of the extracting-focusing system. The parameters of the beam leaving the ion source have been determined; these are used to calculate the electrostatic lenses with the gaussian optics. Measurements concerning deuterium and tritium targets as neutron sources have been made and the processes affecting their practical service life are analyzed. (Author) 71 refs.
Artículos humanísticos en Flora Montiberica (1-50 [Humanistic articles in Flora Montiberica (1-50
Directory of Open Access Journals (Sweden)
José María de Jaime Lorén
2012-07-01
Full Text Available Resumen: Realizamos un breve estudio de los artículos de carácter histórico y humanístico publicados en los cincuenta primeros números de la revista Flora Montiberica, que demuestra notable el interés de la misma por estos temas. También la especialización de ciertos colaboradores, así como el atractivo que para muchos botánicos tienen los aspectos históricos relacionados con la ciencia que estudian. Summary: Humanistic articles in Flora Montiberica (1-50. We´ve carried out a brief study about the articles of historical and humanistic nature published in the first fifty numbers of the journal Flora Montiberica, this one demonstrates significant interest on these issues. Also the specialization of certain contributors, as well as the charm it have for many botanists the historical aspects related to the science they study.
Interfacial (Fiber-matrix) Properties of High-strength Mortar (150 MPa) from Fiber Pullout
DEFF Research Database (Denmark)
Shannag, M.J.; Brincker, Rune; Hansen, Will
1996-01-01
The steel fiber-matrix properties of high-strength mortar (150 MPa), such as DSP (densified small particle), are obtained and compared to an ordinary strength mortar (40 MPa) using a specially designed fiber pullout apparatus. A new method for estimating the debonding energy of the interfacial z......-strength DSP mortar has significantly improved interfacial properties compared to ordinary strength mortar. These results are important in the understanding of the role of steel fibers in improving the tensile properties of high-strength, brittle, cement-matrix composites....... The steel fiber-matrix properties of high-strength mortar (150 MPa), such as DSP (densified small particle), are obtained and compared to an ordinary strength mortar (40 MPa) using a specially designed fiber pullout apparatus. A new method for estimating the debonding energy of the interfacial...
Depleted Monolithic Pixels (DMAPS) in a 150 nm technology: lab and beam results
International Nuclear Information System (INIS)
Obermann, T.; Hemperek, T.; Hügging, F.; Krüger, H.; Pohl, D.-L.; Wermes, N.; Schwenker, B.
2017-01-01
The fully depleted monolithic active pixel sensor (DMAPS) is a new concept integrating full CMOS circuitry onto a fully depletable silicon substrate wafer. The realization of prototypes of the DMAPS concept relies on the availability of multiple well CMOS processes and high resistive substrates. The CMOS foundry ESPROS Photonics offers both and was chosen for prototyping. Two prototypes, EPCB01 and EPCB02, were developed in a 150 nm process on a high resistive n-type wafer of 50 μm thickness. The prototypes have 352 square pixels of 40 μm pitch and small n-well charge collection node with very low capacitance (n + -implantation size: 5 μm by 5 μm) and about 150 transistors per pixel (CSA and discriminator plus a small digital part).
Level Lifetime Measurements in ^150Sm
Barton, C. J.; Krücken, R.; Beausang, C. W.; Caprio, M. A.; Casten, R. F.; Cooper, J. R.; Hecht, A. A.; Newman, H.; Novak, J. R.; Pietralla, N.; Wolf, A.; Zyromski, K. E.; Zamfir, N. V.; Börner, H. G.
2000-10-01
Shape/phase coexistence and the evolution of structure in the region around ^152Sm have recently been of great interest. Experiments performed at WNSL, Yale University, measured the lifetime of low spin states in a target of ^150Sm with the recoil distance method (RDM) and the Doppler-shift attenuation method (DSAM). The low spin states, both yrast and non-yrast, were populated via Coulomb excitation with a beam of ^16O. The experiments were performed with the NYPD plunger in conjunction with the SPEEDY γ-ray array. The SCARY array of solar cells was used to detect backward scattered projectiles, selecting forward flying Coulomb excited target nuclei. The measured lifetimes yield, for example, B(E2) values for transitions such as the 2^+2 arrow 2^+1 and the 2^+3 arrow 0^+_1. Data from the RDM measurment and the DSAM experiment will be presented. This work was supported by the US DOE under grants DE-FG02-91ER-40609 and DE-FG02-88ER-40417.
Directory of Open Access Journals (Sweden)
Eliton da Silva Vasconcelos
2013-12-01
Full Text Available Clavulanic acid (CA is a powerful inhibitor of the beta-lactamases, enzymes produced by bacteria resistants to penicillin and cefalosporin. This molecule is produced industrially by strains of Streptomyces clavuligerus in complex media which carbon and nitrogen resources are supplied by inexpensive compounds still providing high productivity. The genetic production improvement using physical and chemical mutagenic agents is an important strategy in programs of industrial production development of bioactive metabolites. However, parental strains are susceptible to loss of their original productivity due genetic instability phenomenona. In this work, some S. clavuligerus mutant strains obtained by treatment with UV light and with MMS are compared with the wild type (Streptomyces clavuligerus ATCC 27064. The results indicated that the random mutations originated some strains with different phenotypes, most divergent demonstrated by the mutants strains named AC116, MMS 150 and MMS 54, that exhibited lack of pigmentation in their mature spores. Also, the strain MMS 150 presented a larger production of CA when cultivated in semi-synthetics media. Using other media, the wild type strain obtained a larger CA production. Besides, using the modifed complex media the MMS 150 strain showed changes in its lipolitic activity and a larger production of CA. The studies also allowed finding the best conditions for a lipase activity exhibited by wild type S. clavuligerus and the MMS150 mutant.
da Silva Vasconcelos, Eliton; de Lima, Vanderlei Aparecido; Goto, Leandro Seiji; Cruz-Hernández, Isara Lourdes; Hokka, Carlos Osamu
2013-12-01
Clavulanic acid (CA) is a powerful inhibitor of the beta-lactamases, enzymes produced by bacteria resistants to penicillin and cefalosporin. This molecule is produced industrially by strains of Streptomyces clavuligerus in complex media which carbon and nitrogen resources are supplied by inexpensive compounds still providing high productivity. The genetic production improvement using physical and chemical mutagenic agents is an important strategy in programs of industrial production development of bioactive metabolites. However, parental strains are susceptible to loss of their original productivity due genetic instability phenomenona. In this work, some S. clavuligerus mutant strains obtained by treatment with UV light and with MMS are compared with the wild type (Streptomyces clavuligerus ATCC 27064). The results indicated that the random mutations originated some strains with different phenotypes, most divergent demonstrated by the mutants strains named AC116, MMS 150 and MMS 54, that exhibited lack of pigmentation in their mature spores. Also, the strain MMS 150 presented a larger production of CA when cultivated in semi-synthetics media. Using other media, the wild type strain obtained a larger CA production. Besides, using the modifed complex media the MMS 150 strain showed changes in its lipolitic activity and a larger production of CA. The studies also allowed finding the best conditions for a lipase activity exhibited by wild type S. clavuligerus and the MMS150 mutant.
miR-184 and miR-150 promote renal glomerular mesangial cell aging by targeting Rab1a and Rab31.
Liu, Xiujuan; Fu, Bo; Chen, Dapeng; Hong, Quan; Cui, Jing; Li, Jin; Bai, Xueyuan; Chen, Xiangmei
2015-08-15
The molecular mechanism of kidney aging is not well understood, but the abnormal expression of miRNAs with aging is considered to be an important contributor. miR-184 and miR-150 were screened using a miRNA microarray and qRT-PCR and found to be significantly upregulated in 24-month-old rats. Rat renal primary glomerular mesangial cells (GMCs) were isolated from 3-month and 24-month-old rats for the in vitro analysis of the roles of miR-184 and miR-150 in kidney aging. Bioinformatics analyses suggested that Rab1a and Rab31, which are associated with cell autophagy, were targeted by both miR-184 and miR-150. miR-184 and miR-150 were increased significantly in aging GMCs versus young cells, while Rab1a and Rab31 were significantly lower in aging cells. Furthermore, dual luciferase reporter assays revealed that miR-184 and miR-150 bound to the 3'-UTR of Rab1a and Rab31 mRNAs. Transfection of miR-184 and miR-150 mimics into young GMCs suppressed the expression of Rab1a and Rab31. Transfected cells showed lower autophagy activities and higher levels of cellular oxidative products, leading to the aging of young GMCs. However, miR-184 and miR-150 inhibitors promoted autophagy and reduced oxidative damage by upregulating Rab1a and Rab31 in old GMCs. In conclusion, miR-184 and miR-150 inhibited autophagy, promoting GMC aging. Copyright © 2015 Elsevier Inc. All rights reserved.
Method of isolation of traces of americium by using the +6 oxidation state properties
International Nuclear Information System (INIS)
Kwinta, Jean; Michel, Jean-Jacques
1969-05-01
The authors present a method to separate traces of americium from a solution containing fission products and actinides. This method comprises the following steps: firstly, the oxidation of americium at the +6 state by ammonium persulfate and carrying over of actinides and III and IV lanthanides by lanthanum fluoride; secondly, the reduction by hydrazine of the oxidized americium and carrying over of the reduced americium by lutetium fluoride; and thirdly, the americium-lutetium separation by selective extractions either with di 2 ethyl hexyl phosphoric acid, or by fractionated elution on an anionic resin column by a mixture of nitric acid and methanol [fr
Directory of Open Access Journals (Sweden)
Jiang Pi
Full Text Available High levels of intracellular reactive oxygen species (ROS in cells is recognized as one of the major causes of cancer cell apoptosis and has been developed into a promising therapeutic strategy for cancer therapy. However, whether apoptosis associated biophysical properties of cancer cells are related to intracellular ROS functions is still unclear. Here, for the first time, we determined the changes of biophysical properties associated with the ROS-mediated oesophageal cancer KYSE-150 cell apoptosis using high resolution atomic force microscopy (AFM. Oridonin was proved to induce ROS-mediated KYSE-150 cell apoptosis in a dose dependent manner, which could be reversed by N-acetylcysteine (NAC pretreatment. Based on AFM imaging, the morphological damage and ultrastructural changes of KYSE-150 cells were found to be closely associated with ROS-mediated oridonin-induced KYSE-150 cell apoptosis. The changes of cell stiffness determined by AFM force measurement also demonstrated ROS-dependent changes in oridonin induced KYSE-150 cell apoptosis. Our findings not only provided new insights into the anticancer effects of oridonin, but also highlighted the use of AFM as a qualitative and quantitative nanotool to detect ROS-mediated cancer cell apoptosis based on cell biophysical properties, providing novel information of the roles of ROS in cancer cell apoptosis at nanoscale.
Directory of Open Access Journals (Sweden)
Arora S
2014-06-01
Full Text Available Sumit Arora,1 Suresh K Swaminathan,2 Ameya Kirtane,2 Sanjeev K Srivastava,1 Arun Bhardwaj,1 Seema Singh,1 Jayanth Panyam,2 Ajay P Singh1,3 1Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA; 2Department of Pharmaceutics, The University of Minnesota, Minneapolis, USA; 3Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA Abstract: MicroRNAs are small (18–22 nucleotide long noncoding RNAs that play important roles in biological processes through posttranscriptional regulation of gene expression. Their aberrant expression and functional significance are reported in several human malignancies, including pancreatic cancer. Recently, we identified miR-150 as a novel tumor suppressor microRNA in pancreatic cancer. Furthermore, expression of miR-150 was downregulated in the majority of tumor cases, suggesting that its restoration could serve as an effective approach for pancreatic cancer therapy. In the present study, we developed a nanoparticle-based miR-150 delivery system and tested its therapeutic efficacy in vitro. Using double emulsion solvent evaporation method, we developed a poly (D,L-lactide-co-glycolide (PLGA-based nanoformulation of miR-150 (miR-150-NF. Polyethyleneimine (a cationic polymer was incorporated in PLGA matrix to increase the encapsulation of miR-150. Physical characterization of miR-150-NF demonstrated that these nanoparticles had high encapsulation efficiency (~78% and exhibited sustained release profile. Treatment of pancreatic cancer cells with miR-150-NF led to efficient intracellular delivery of miR-150 mimics and caused significant downregulation of its target gene (MUC4 expression. Inhibition of MUC4 correlated with a concomitant decrease in the expression of its interacting partner, HER2, and repression of its downstream signaling. Furthermore, treatment of pancreatic cancer cells with
45 CFR 2544.150 - How will accepted donations be recorded and used?
2010-10-01
... 45 Public Welfare 4 2010-10-01 2010-10-01 false How will accepted donations be recorded and used... FOR NATIONAL AND COMMUNITY SERVICE SOLICITATION AND ACCEPTANCE OF DONATIONS § 2544.150 How will accepted donations be recorded and used? (a) All accepted donations of money and other property will be...
2010-03-10
... DEPARTMENT OF LABOR Employee Benefits Security Administration 150th Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of Meeting Pursuant to the authority... 150th open meeting of the full Advisory Council on Employee Welfare and Pension Benefit Plans will be...
International Nuclear Information System (INIS)
Stierman, R.J.
1982-12-01
Results for pure Sc show that the maximum and minimum in the susceptibility discovered earlier are enhanced as the impurity level of iron in scandium decreases. The Stoner enhancement factor, calculated from low-temperature heat capacity data, susceptibility data, and band-structure calculations show Sc to be a strongly enhanced paramagnet. Below 2 0 K, the magnetic anisotropy between the hard and easy directions of scandium decreases linearly with decreasing temperature, tending toward zero at 0 K. The large increase in the susceptibility of Sc at lower temperatures indicates magnetic ordering. Pure Lu and Lu-H alloys showed an anisotropy in susceptibility vs orientation; thus the samples were not random polycrystalline samples. Pure Lu shows the shallow maximum and minimum, but the increase in susceptibility at low temperatures is larger than previously observed. The susceptibility-composition dependence of the Lu-H alloys also did not match other data. The susceptibility-composition dependence does not match the composition dependence of the electronic specific heat constant below 150 K, showing the electronic specific heat is being affected by terms other than phonon-electron and pure electron-electron interactions
International Nuclear Information System (INIS)
Zhao, Yanxing; Dong, Xueqiang; Zhong, Quan; Gong, Maoqiong; Shen, Jun
2017-01-01
Highlights: • The vapour liquid equilibrium for ammonia + 1,1,1,2-tetrafluoroethane system was studied. • Measurements were based on vapour phase single recirculation method. • A positive azeotropic behaviour was exhibited at the experimental temperature range. - Abstract: To blend ammonia with some hydrofluorocarbons may give these mixed refrigerants lower flammability and global warming potential. In this paper, the isothermal vapour liquid equilibrium (VLE) of (ammonia + 1,1,1,2-tetrafluoroethane) system at temperatures ranging from (243.150 to 283.150) K are presented. Two models were employed to regress the experimental VLE results, namely the Peng–Robinson (PR) equation of state with the simple van der waals (VDW) mixing rule; the Peng–Robinson equation of state combined non-random two-liquid (NRTL) activity coefficient model with the modified Huron-Vidal one-order (MHV1) mixing rule. The maximum average absolute relative deviation of pressure (AARDp) and average absolute deviation of the vapour phase mole fraction (AADy) for PR-VDW are 0.56% and 0.010, respectively, while the maximum AARDp and AADy for PR-MHV1-NRTL are 0.27% and 0.014, respectively. Positive azeotropic behaviour was exhibited at each temperature investigated.
The design and performance of 150-MW S-band klystrons
International Nuclear Information System (INIS)
Sprehn, D.; Phillips, R.M.; Caryotakis, G.
1994-09-01
As part of an international collaboration, the Stanford Linear Accelerator Center (SLAC) klystron group has designed, fabricated and tested a 60 Hz, 3 μs, 150 MW klystron built for Deutsches Elektronen Synchrotron (DESY). A test diode with a 535 kV, 700 A electron beam was constructed to verify the gun operation. The first klystron was built and successfully met design specifications. This paper discusses design issues and experimental results of the diode and klystron including the suppression of gun oscillations
Studies on the properties of poly (ethylene oxide) R-150 hydrogel films formed by irradiation graft
International Nuclear Information System (INIS)
Yang Zhanshan; Zhu Nankang; Yang Shuqin; Qiang Yizhong
1999-01-01
In order to improve the mechanical properties of poly (ethylene oxide) (PEO) hydrogel film was used as wound dressing. The chemical and physical properties of the PEO R-150 graft hydrogel film formed by blends of electron beam irradiated-PEO R-150 and poly(vinyl alcohol) (PVA) were studied. The experimental results showed that the crosslinking densities of the PEO R-150 graft hydrogel increased along with the increasing of the irradiation doses and decreased with the increasing of the blend concentrations. While the PVA graft proportions did not produce obvious effects on the crosslinking density of the graft hydrogel. The crosslinking density of the graft hydrogel were obviously lower than that of the pure PVA hydrogel. The equilibrium water content of the graft hydrogel decrease as the irradiation dose and the PVA graft proportion increased; but they increased as the blend concentration increased. The equilibrium water content of the graft hydrogel was obviously higher than those of the pure PVA hydrogel. The hardness of the PVA hydrogel film increased with the irradiation dose. The hardness of the graft hydrogel decreased with the blend concentration, whereas it increased with the PVA graft proportion. The results suggest the PVA produces a main effect on the crosslinking density of the graft hydrogel, the PEO R-150 produces a main effect on the equilibrium water content of the graft hydrogel, and the both polymers have double effects on the hardness of the graft hydrogel
Directory of Open Access Journals (Sweden)
F. S. Rodrigues
2013-10-01
Full Text Available Previous studies showed that conventional coherent backscatter radar measurements of the Doppler velocity of the so-called 150 km echoes can provide an alternative way of estimating ionospheric vertical plasma drifts during daytime hours (Kudeki and Fawcett, 1993; Chau and Woodman, 2004. Using observations made by a small, low-power 30 MHz coherent backscatter radar located in the equatorial site of São Luís (2.59° S, 44.21° W; −2.35° dip lat, we were able to detect and monitor the occurrence of 150 km echoes in the Brazilian sector. Using these measurements we estimated the local time variation of daytime vertical ionospheric drifts in the eastern American sector. Here, we present a few interesting cases of 150 km-echoes observations made by the São Luís radar and estimates of the diurnal variation of vertical drifts. These cases exemplify the variability of the vertical drifts in the Brazilian sector. Using same-day 150 km-echoes measurements made at the Jicamarca Radio Observatory in Peru, we also demonstrate the variability of the equatorial vertical drifts across the American sector. In addition to first estimates of the absolute vertical plasma drifts in the eastern American (Brazilian sector, we also present observations of abnormal drifts detected by the São Luís radar associated with the 2009 major sudden stratospheric warming event.
[150 cases of vedio-laparoscopic gynecologic surgery].
Liu, Y; Hui, N
1994-04-01
From September 1992 to September 1993, 150 patients aged 15-68 years underwent laparoscopic gynecologic surgery. These patients included 63 patients with acute abdominal diseases (46 had ectopic pregnancy, 9 rupture of ovary, and 8 torsion of ovarian cyst), which consisted of 90% of total patients with acute abdomen in corresponding period, 63 patients with mass of adnexa, which made up 72% of total patients with ovarian tumors, and 24 patients with uterine diseases. We successfully performed laparoscopic salpingostomy, fallotomy, removal of ovarian cyst, oophorosalpingectomy, myomectomy and laparoscopy assisted vaginal hysterectomy (LAVH) with 2-4 puncture technic after general anesthesia. The largest ovarian tumor and the enlarged uterus were 14 and 16 cm in diameter respectively. Four patients had laparotomy because of severe pelvic adhesions and the laparotomy rate was about 2.6%. The procedure lasted 20-240 minutes and bleeding was less than 200ml. No major surgical complication was encountered.
International Nuclear Information System (INIS)
Guo, Hao; Gong, Maoqiong; Dong, Xueqiang; Wu, Jianfeng
2012-01-01
Highlights: ► VLE data for the {R152a + R134} system were measured. ► The experiment is based on the static–analytic method. ► The VLE data were correlated using the PR–HV–NRTL model. ► A negative azeotropic behaviour was found. - Abstract: (Vapour + liquid) equilibrium (VLE) data for the {1,1-difluoroethane (R152a) + 1,1,2,2-Tetrafluoroethane (R134)} system were measured at T = (258.150 to 288.150) K. The experiment is based on a static–analytic method. Experimental data were correlated with the Peng–Robinson equation of state (PR EoS) and the Huron–Vidal (HV) mixing rule involving the NRTL activity coefficient model. The results show good agreement with experimental results for the binary system at each temperature. It was found that the system has a negative azeotropic behaviour within the temperature range measured here.
Electronics system for the 150 kV negative ion test stand at BNL
International Nuclear Information System (INIS)
Larson, R.A.
1977-01-01
The 150 kV test stand at BNL is being used to investigate the extraction, acceleration and transport problems associated with the development of intense negative ion beams. The power supplies associated with these functions as well as the control and monitoring electronics are described
Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer
DEFF Research Database (Denmark)
McLeod, David G; Iversen, Peter; See, William A
2006-01-01
To evaluate, in the ongoing Early Prostate Cancer (EPC) trial programme, the efficacy and tolerability of bicalutamide 150 mg once daily in addition to standard care for localized or locally advanced, nonmetastatic prostate cancer....
High-spin states in the transitional odd-odd nuclei 150Eu and 152Tb
International Nuclear Information System (INIS)
Barneoud, D.; Foin, C.; Pinston, J.A.; Monnand, E.
1983-06-01
The ( 7 Li, 5n) and ( 11 B, 5n) reactions have been used to study the high-spin states in the two odd-odd nuclei 150 Eu and 152 Tb. Three decoupled bands have been evidenced in each nucleus belonging to the same configurations [f 7/2]sub(n) [h 11/2]sub(p), [h 9/2]sub(n) [h 11/2 ]sub(p) and [i 13/2]sub(n) [h 11/2]sub(p). The latter one is well developped and improves our knowledge of this system between the spherical and deformed region. The analysis of the collective moment of inertia and transition ratios strongly suggests an increase of the deformation when the rotational frequency increases in these two transitional nuclei 150 Eu and 152 Tb
Directory of Open Access Journals (Sweden)
Lulu Farhana
Full Text Available MicroRNAs have been implicated in many critical cellular processes including apoptosis. We have previously found that apoptosis in pancreatic cancer cells was induced by adamantyl retinoid-related (ARR molecule 3-Cl-AHPC. Here we report that 3-Cl-AHPC-dependent apoptosis involves regulating a number of microRNAs including miR-150* and miR-630. 3-Cl-AHPC stimulated miR-150* expression and caused decreased expression of c-Myb and IGF-1R in the pancreatic cancer cells. 3-Cl-AHPC-mediated reduction of c-Myb resulted in diminished binding of c-Myb with IGF-1R and Bcl-2 promoters, thereby causing repression of their transcription and protein expression. Over-expression of miR-150* also resulted in diminished levels of c-Myb and Bcl-2 proteins. Furthermore, the addition of the miRNA inhibitor 2'-O-methylated miR-150 blocked 3-Cl-AHPC-mediated increase in miR-150* levels and abrogated loss of c-Myb protein. Knockdown of c-Myb in PANC-1 cells resulted in enhanced apoptosis both in the presence or absence of 3-Cl-AHPC confirming the anti-apoptotic property of c-Myb. Overexpression of miR-630 also induced apoptosis in the pancreatic cancer cells and inhibited target protein IGF-1R mRNA and protein expression. Together these results implicate key roles for miR-150* and miR-630 and their targeting of IGF-1R to promote apoptosis in pancreatic cancer cells.
International Nuclear Information System (INIS)
Yang, Lixiang; Gong, Maoqiong; Guo, Hao; Dong, Xueqiang; Wu, Jianfeng
2015-01-01
Highlights: • VLE data for (R152a + R245fa) system were measured at temperatures. • The experiments were based on the static-analytic method. • VLE data were correlated using PR–vdWs and PR–HV–NRTL models. - Abstract: In this paper, (vapour + liquid) equilibrium (VLE) for the {1,1-difluoroethane (R152a) + 1,1,1,3,3-pentafluoropropane (R245fa)} system was determined by a static-analytical method at T = (323.150 to 353.150) K. Values of the VLE were correlated by the Peng–Robison equation of state (PR EoS) using two different models, the van der Waals (vdWs) mixing rule and the Huron–Vidal (HV) mixing rule involving the non-random two-liquid (NRTL) activity coefficient model. The correlated results show good agreement with the experimental values. For the two models, the maximum average absolute deviations of the vapour phase mole fraction are 0.0034 and 0.0035, respectively.
DEFF Research Database (Denmark)
Tyrrell, C J; Kaisary, A V; Iversen, P
1998-01-01
To evaluate the efficacy and tolerability of 'Casodex' monotherapy (150 mg daily) for metastatic and locally advanced prostate cancer.......To evaluate the efficacy and tolerability of 'Casodex' monotherapy (150 mg daily) for metastatic and locally advanced prostate cancer....
45 CFR 150.317 - Factors CMS uses to determine the amount of penalty.
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Factors CMS uses to determine the amount of... RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS CMS Enforcement With Respect to Issuers and Non-Federal Governmental Plans-Civil Money Penalties § 150.317 Factors CMS...
Evolution of deformation in neutron-rich Ba isotopes up to A =150
Licǎ, R.; Benzoni, G.; Rodríguez, T. R.; Borge, M. J. G.; Fraile, L. M.; Mach, H.; Morales, A. I.; Madurga, M.; Sotty, C. O.; Vedia, V.; De Witte, H.; Benito, J.; Bernard, R. N.; Berry, T.; Bracco, A.; Camera, F.; Ceruti, S.; Charviakova, V.; Cieplicka-Oryńczak, N.; Costache, C.; Crespi, F. C. L.; Creswell, J.; Fernandez-Martínez, G.; Fynbo, H.; Greenlees, P. T.; Homm, I.; Huyse, M.; Jolie, J.; Karayonchev, V.; Köster, U.; Konki, J.; Kröll, T.; Kurcewicz, J.; Kurtukian-Nieto, T.; Lazarus, I.; Lund, M. V.; Mǎrginean, N.; Mǎrginean, R.; Mihai, C.; Mihai, R. E.; Negret, A.; Orduz, A.; Patyk, Z.; Pascu, S.; Pucknell, V.; Rahkila, P.; Rapisarda, E.; Regis, J. M.; Robledo, L. M.; Rotaru, F.; Saed-Samii, N.; Sánchez-Tembleque, V.; Stanoiu, M.; Tengblad, O.; Thuerauf, M.; Turturica, A.; Van Duppen, P.; Warr, N.; IDS Collaboration
2018-02-01
The occurrence of octupolar shapes in the Ba isotopic chain was recently established experimentally up to N =90 . To further extend the systematics, the evolution of shapes in the most neutron-rich members of the Z =56 isotopic chain accessible at present, Ba,150148, has been studied via β decay at the ISOLDE Decay Station. This paper reports on the first measurement of the positive- and negative-parity low-spin excited states of 150Ba and presents an extension of the β -decay scheme of 148Cs. Employing the fast timing technique, half-lives for the 21+ level in both nuclei have been determined, resulting in T1 /2=1.51 (1 ) ns for 148Ba and T1 /2=3.4 (2 ) ns for 150Ba. The systematics of low-spin states, together with the experimental determination of the B (E 2 :2+→0+) transition probabilities, indicate an increasing collectivity in Ba-150148, towards prolate deformed shapes. The experimental data are compared to symmetry conserving configuration mixing (SCCM) calculations, confirming an evolution of increasingly quadrupole deformed shapes with a definite octupolar character.
International Nuclear Information System (INIS)
Langen, K M; Binns, P J; Schreuder, A N; Lennox, A J; Deluca, P M Jr.
2003-01-01
The ICRU tissue to A-150 tissue equivalent plastic kerma ratio is needed for neutron therapy dosimetry. The current ICRU protocol for neutron dosimetry recommends using a common conversion factor of 0.95 at all high-energy neutron therapy facilities. In an effort to determine facility specific ICRU tissue to A-150 plastic kerma ratios, an experimental approach was pursued. Four low pressure proportional counters that differed in wall materials (i.e. A-150, carbon, zirconium and zirconium-oxide) were used as dosimeters and integral kerma ratios were determined directly in the clinical beam. Measurements were performed at two p(66)Be facilities: iThemba LABS near Cape Town and Fermilab near Chicago. At the iThemba facility the clinical neutron beam is routinely filtered by a flattening and hardening filter combination. The influence of beam filtration on the kerma ratio was evaluated. Using two recent gas-to-wall dose conversion factor (r m,g value) evaluations a mean ICRU tissue to A-150 plastic kerma ratio of 0.93 ± 0.05 was determined for the clinical beam at iThemba LABS. The respective value for the Fermilab beam is 0.95 ± 0.05. The experimentally determined ICRU tissue to A-150 plastic kerma ratios for the two clinical beams are in agreement with theoretical evaluations. Beam filtration reduces the kerma ratio by 3 ± 2%
15.0 MeV/u He2+ ion-induced low energy electrons from water vapor
International Nuclear Information System (INIS)
Okada, Y.; Sato, Y.; Soga, F.; Ohsawa, D.
2005-01-01
We present the absolute doubly differential cross sections (DDCS) of low-energy electrons and their angular distributions (20deg - 160deg ) produced in the collisions of 15.0 MeV/u He 2+ ions with water vapor. Details of the experiments by 6.0 and 10.0 MeV/u He 2+ ions were already reported in our previous paper, in which the total uncertainty (±13%) was discussed. This paper shows the absolute DDCS data (1 - 100 eV) by 15.0 MeV/u He 2+ ions, in which the cover surrounding the interaction region was changed to μ-metal from Cu, in order to suppress the residual magnetic field for measuring the low-energy electrons effectively. (author)
Directory of Open Access Journals (Sweden)
Xiao-ke Shi
2017-05-01
Full Text Available Recent studies indicate that mitochondrial pathways of apoptosis are potential chemotherapeutic target for the treatment of esophageal cancer. Azoxystrobin (AZOX, a methoxyacrylate derived from the naturally occurring strobilurins, is a known fungicide acting as a ubiquinol oxidation (Qo inhibitor of mitochondrial respiratory complex III. In this study, the effects of AZOX on human esophageal squamous cell carcinoma KYSE-150 cells were examined and the underlying mechanisms were investigated. AZOX exhibited inhibitory effects on the proliferation of KYSE-150 cells with inhibitory concentration 50% (IC50 of 2.42 μg/ml by 48 h treatment. Flow cytometry assessment revealed that the inhibitory effect of AZOX on KYSE-150 cell proliferation occurred with cell cycle arrest at S phase and increased cell apoptosis in time-dependent and dose-dependent manners. Cleaved poly ADP ribose polymerase (PARP, caspase-3 and caspase-9 were increased significantly by AZOX. It is worth noted that the Bcl-2/Bax ratios were decreased because of the down-regulated Bcl-2 and up-regulated Bax expression level. Meanwhile, the cytochrome c release was increased by AZOX in KYSE-150 cells. AZOX-induced cytochrome c expression and caspase-3 activation was significantly blocked by Bax Channel Blocker. Intragastric administration of AZOX effectively decreased the tumor size generated by subcutaneous inoculation of KYSE-150 cells in nude mice. Consistently, decreased Bcl-2 expression, increased cytochrome c and PARP level, and activated caspase-3 and caspase-9 were observed in the tumor samples. These results indicate that AZOX can effectively induce esophageal cancer cell apoptosis through the mitochondrial pathways of apoptosis, suggesting AZOX or its derivatives may be developed as potential chemotherapeutic agents for the treatment of esophageal cancer.
A 150 kV Isolation Transformer for a Neutron Generator
International Nuclear Information System (INIS)
Dechthummarong, C.; Pratumtip, P.; Thongleurm, C.; Vichaimongkol, P.; Charoennugul, R.; Vilaithong, T.
1998-01-01
The work aims at the design and construction of a 150 kV isolation transformer for a neutron generator. The transformer windings are designed to use cylindrical layers with circular enamel copper wires. The insulation of the dry type transformer uses the epoxy resin for encapsulated winding. This insulation is non-flammable under temperature 350 degree celsius and the breakdown voltage is 10-18 kV/mm. This insulation is suitable for insulating high voltage. The design of provides the temperature rise of winding not exceeding 65 degree celsius for protection of the cracking of epoxy resin due to the expansion of winding
2010-04-30
... CAN USA, Inc., Harvey, Louisiana; General License Pursuant to 10 CFR 150.20; Confirmatory Order (Effective Immediately) I CAN USA, Inc. (CAN USA or Licensee) is the holder of State of Louisiana Materials..., pursuant to 10 CFR 150.20(a)(1), CAN USA is granted a general license by the U.S. Nuclear Regulatory...
International Nuclear Information System (INIS)
Lopez G, H.D.
2005-01-01
The behavior of lanthanum (III), praseodymium (III), and lutetium (III) was studied in 2 M NaClO 4 (aq) and 2 M NaCl (aq) at 303 K and free -CO 2 conditions. Solubility diagrams (p Ln(aq)-pC H ) were obtained by means of a radiochemical method. The pC H borderlines of saturation and unsaturation zones of the solutions and solubility product constants for Ln(OH) 3 were determined from these diagrams. The fitting of the solubility equation to the experimental values of p Ln(aq)-pC H diagrams allowed the calculation of the first hydrolysis and solubility product constants. Independently, the stability constants for the first species of hydrolysis were determined by means of pH titrations, the data were treated with the program SUPERQUAD and fitted to the mean ligand number equation. The stability constants for the species LnCl 2+ were as well calculated in 2M ionic strength and 303 K from the hydrolysis constant values obtained in both perchlorate and chloride media. The values obtained for La, Pr and Lu were: logK ps : 21.11 ± 0.09, 19.81 ± 0.11 and 18.10 ± 0.13 in 2M NaClO 4 ; logK ps : 22.22 ± 0.09, 21.45 ± 0.14 and 18.52 ± 0.29 in 2M NaCl; log β 1 : - 8.64 ± 0.02, - 8.37 ± 0.01 and - 7.95 ± 0.11 in 2M NaClO 4 ; log β 1 / : - 9.02 ± 0.11, - 8.75 ± 0.01 and - 8.12 ± 0.03 in 2M NaCl and the values for log β 1,Cl were - 0.0255, - 0.155 and - 0.758, respectively. (Author)
Stability of A-150 plastic ionization chamber response over a ∼30 year period
International Nuclear Information System (INIS)
Kroc, Thomas K.; Lennox, Arlene J.
2007-01-01
At the NIU Institute for Neutron Therapy at Fermilab, the clinical tissue-equivalent ionization chamber response is measured every treatment day using a cesium source that was configured to match readings obtained at the National Bureau of Standards. Daily measurements are performed in air using the air-to-tissue dose conversion factors given in AAPM Report no. 7. The measured exposure calibration factors have been tabulated and graphed as a function of time from 1978 to present. For A-150 plastic ionization chambers, these factors exhibit a sinusoidal variation with a period of approximately one year and amplitude of ± 1%. This variation, attributable to the hygroscopic nature of A-150 plastic, is correlated with the relative humidity of the facility, and is greater than the humidity corrections for gas described in the literature. Our data suggest that chamber calibration should be performed at least weekly to accommodate these variations
26 CFR 1.50B-1 - Definitions of WIN expenses and WIN employees.
2010-04-01
... employee. (c) Trade or business expenses. The term “WIN expenses” includes only salaries and wages which... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Definitions of WIN expenses and WIN employees. 1... INCOME TAXES Rules for Computing Credit for Expenses of Work Incentive Programs § 1.50B-1 Definitions of...
A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.
Barnable, Patrick; Calenda, Giulia; Ouattara, Louise; Gettie, Agegnehu; Blanchard, James; Jean-Pierre, Ninochka; Kizima, Larisa; Rodríguez, Aixa; Abraham, Ciby; Menon, Radhika; Seidor, Samantha; Cooney, Michael L; Roberts, Kevin D; Sperling, Rhoda; Piatak, Michael; Lifson, Jeffrey D; Fernandez-Romero, Jose A; Zydowsky, Thomas M; Robbiani, Melissa; Teleshova, Natalia
2014-01-01
To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M) and zinc acetate dihydrate (ZA) in carrageenan (CG) (MZC) inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV)-RT in macaques, we evaluated safety and anti-SHIV-RT activity of MZC and related gel formulations ex vivo in macaque mucosal explants. In addition, safety was further evaluated in human ectocervical explants. The gels did not induce mucosal toxicity. A single ex vivo exposure to diluted MZC (1∶30, 1∶100) and MC (1∶30, the only dilution tested), but not to ZC gel, up to 4 days prior to viral challenge, significantly inhibited SHIV-RT infection in macaque vaginal mucosa. MZC's activity was not affected by seminal plasma. The antiviral activity of unformulated MIV-150 was not enhanced in the presence of ZA, suggesting that the antiviral activity of MZC was mediated predominantly by MIV-150. In vivo administration of MZC and CG significantly inhibited ex vivo SHIV-RT infection (51-62% inhibition relative to baselines) of vaginal (but not cervical) mucosa collected 24 h post last gel exposure, indicating barrier effect of CG. Although the inhibitory effect of MZC (65-74%) did not significantly differ from CG (32-45%), it was within the range of protection (∼75%) against vaginal SHIV-RT challenge 24 h after gel dosing. Overall, the data suggest that evaluation of candidate microbicides in macaque explants can inform macaque efficacy and clinical studies design. The data support advancing MZC gel for clinical evaluation.
A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.
Directory of Open Access Journals (Sweden)
Patrick Barnable
Full Text Available To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M and zinc acetate dihydrate (ZA in carrageenan (CG (MZC inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV-RT in macaques, we evaluated safety and anti-SHIV-RT activity of MZC and related gel formulations ex vivo in macaque mucosal explants. In addition, safety was further evaluated in human ectocervical explants. The gels did not induce mucosal toxicity. A single ex vivo exposure to diluted MZC (1∶30, 1∶100 and MC (1∶30, the only dilution tested, but not to ZC gel, up to 4 days prior to viral challenge, significantly inhibited SHIV-RT infection in macaque vaginal mucosa. MZC's activity was not affected by seminal plasma. The antiviral activity of unformulated MIV-150 was not enhanced in the presence of ZA, suggesting that the antiviral activity of MZC was mediated predominantly by MIV-150. In vivo administration of MZC and CG significantly inhibited ex vivo SHIV-RT infection (51-62% inhibition relative to baselines of vaginal (but not cervical mucosa collected 24 h post last gel exposure, indicating barrier effect of CG. Although the inhibitory effect of MZC (65-74% did not significantly differ from CG (32-45%, it was within the range of protection (∼75% against vaginal SHIV-RT challenge 24 h after gel dosing. Overall, the data suggest that evaluation of candidate microbicides in macaque explants can inform macaque efficacy and clinical studies design. The data support advancing MZC gel for clinical evaluation.
DEFF Research Database (Denmark)
See, W; Iversen, P; Wirth, M
2003-01-01
To evaluate the effect of bicalutamide ('Casodex') 150mg (in addition to standard care), on the risk of prostate-specific antigen (PSA) progression, in patients with early prostate cancer.......To evaluate the effect of bicalutamide ('Casodex') 150mg (in addition to standard care), on the risk of prostate-specific antigen (PSA) progression, in patients with early prostate cancer....
Measurement of photon showers in lead produced by electrons of 150 MeV
International Nuclear Information System (INIS)
Goeringer, H.; Eyss, H.J. von; Schoch, B.
1976-01-01
The photon energy spectra induced by 150 MeV electrons in lead were measured in the energy range from 40 MeV up to the primary electron energy. The target thickness was varied between 0.1 and 2.5 radiation lengths X 0 . The photons were analyzed by use of a technique based on deuteron photodisintegration. Differential and integral shower spectra are presented and compared with Monte Carlo calculations of Nagel and Messel et al., both interpolated to our primary energy of 150 MeV. The measured spectra show good agreement with these Monte Carlo calculations for the thickest target of 2.5X 0 and with calculated bremsstrahlung spectra for the thinnest target of 0.1X 0 . Considerable discrepancies, however, are found for medium target thicknesses in the range 0 . Around the shower maxima, the shower spectra are narrower and the maxima are shifted about 0.3-0.4X 0 to lower target thicknesses, furthermore the number of photons at the shower maxima are up to 50% higher than calculated. (Auth.)
DEFF Research Database (Denmark)
Støving, René K; Hangaard, Jørgen; Hagen, Claus
2003-01-01
women with AN at the time of diagnosis and after partial weight recovery and in 6 healthy age-matched women serving as controls. RESULTS: Patients with AN had low levels of ALS and IGFBP-3 contained in the 150-kD ternary complex and in the non-150-kD fraction. Following partial weight recovery, the 150......-kD IGFBP-3 ternary complex was fully normalized, despite only partial normalization of serum GH and IGF-I levels. Patients with AN did not present with IGFBP-3 proteolysis different from controls. CONCLUSION: The present data indicate a pivotal role of the nutritional status in the regulation...
DEFF Research Database (Denmark)
Iversen, P; Tyrrell, C J; Kaisary, A V
1998-01-01
To compare the efficacy, tolerability, and quality of life benefits of bicalutamide (Casodex) 150-mg/day monotherapy and castration in previously untreated nonmetastatic (M0) advanced prostate cancer....
Molecular beam (1-50eV) production by duoplasmatron source
International Nuclear Information System (INIS)
Delmas, M.; Gautherin, G.; Lejeune, C.
1974-01-01
The duoplasmatron discharge is commonly used to produce intense ion beams. A theoretical model of this discharge has been previously developed. The analysis of charge exchange processes between ions and neutral within the discharge shows that the source is able to deliver intense neutral beams (10 16 part s -1 ), the energy being in the range 1-50 eV. The intensity and energy distribution may be controlled from the discharge parameter variations. An experimental device has been realized in order to separate the neutral beam and the flux of charged particles; these latter are injected axially in a toroidal magnetic field configuration [fr
Development of Wave Dragon from Scale 1:50 to Prototype
DEFF Research Database (Denmark)
Soerensen, H. C.; Friis-Madsen, E.; Panhauser, W.
2003-01-01
The Wave Dragon is a 4 to 11 MW offshore wave energy converter of the overtopping type. It basically consists of two wave reflectors focusing the waves towards a ramp, a reservoir for collecting the overtopping water and a number of hydro turbines for converting the pressure head into power....... In the period from 1998 to 2001 extensive testing on a scale 1:50 model was carried out. During the last month, testing has started on a prototype of the Wave Dragon in Nissum Bredning, Denmark (wave climate in scale 1:4.5 of the North Sea). The prototype has been grid connected in June 2003 as the world...
γ-Radiation (0-150 kGy) Effects on HDPE/LDPE Blends
International Nuclear Information System (INIS)
Albano, C.
2006-01-01
In the present work, irradiation with 60 C o source was employed to study the effect of γ-rays on some physical properties of HDPE/LDPE blends (0/100, 10/90, 25/75, 50/50, 75/25, 100/0), using various doses: 0, 50, 150 kGy. The blends were prepared by extrusion and plates were compression molded employing fast and slow cooling methods from the melt. Density, degree of crystallinity and mechanical properties were dependant on the cooling rate used and blend composition. Better properties were found for HDPE-rich blends. Mechanical properties showed no significant variations in tensile modulus and yield stress. Instead, a decrease in elongation at break, due to molecular crosslinking or branching reaction effects, with the raise of radiation dose was obtained. Density measurements and differential scanning calorimetry results failed to exhibit significant changes with radiation dose. Some qualitative aspects included changes in endotherms shape. These were attributed to the variation of in crystallite sizes, probably due to structural changes originated by crosslinking and chain scission reactions occurring as a result of γ-rays exposure. On the other hand, there was an abrupt reduction of the melt flow index (MFI) from the range of 16-9 dg/min for 0 kGy to non-fluidity for an exposure of 150 kGy; this behavior is another sign of high crosslinking, impairing the viscous fluidity of the blends
Fission product poisoning in KS-150 reactor operation
International Nuclear Information System (INIS)
Rana, S.B.
1978-01-01
A three-dimensional model of the KS-150 reactor was used to study reactivity changes induced by reactor poisoning with fission products Xe 135 and Sm 149 . A comparison of transients caused by the poisoning showed the following differences: (1) the duration of the transient Xe poisoning (2 days) is shorter by one order of magnitude than the duration of Sm poisoning (20 days); however, the level of Xe poisoning is greater approximately by one order than the level of the Sm poisoning; (2) the level of steady-state Xe poisoning depends on the output level of the reactor; steady-state Sm poisoning does not depend on this level; (3) following reactor shutdown Xe poisoning may increase to the maximum value of up to Δrhosub(Xe)=20% and will then gradually decrease; Sm poisoning may reach maximum values of up to Δrhosub(Sm)=2% and does not decrease. (J.B.)
Directory of Open Access Journals (Sweden)
Inna Gordiienko
Full Text Available Cell surface expression of CD150 and CD180 receptors in chronic lymphocytic leukemia (CLL associates with mutational IGHV status and favourable prognosis. Here we show a direct correlation between cell surface expression and colocalization of these receptors on CLL B cells. In the absence of CD150 and CD180 on the cell surface both receptors were expressed in the cytoplasm. The CD150 receptor was colocalized with markers of the endoplasmic reticulum, the Golgi apparatus and early endosomes. In contrast, CD180 was detected preferentially in early endosomes. Analysis of CD150 isoforms differential expression revealed that regardless of CD150 cell surface expression the mCD150 isoform with two ITSM signaling motifs was a predominant CD150 isoform in CLL B cells. The majority of CLL cases had significantly elevated expression level of the soluble sCD150, moreover CLL B cells secrete this isoform. CD150 or CD180 crosslinking on CLL B cells alone led to activation of Akt, mTORC1, ERK1/2, p38MAPK and JNK1/2 networks. Both CD150 and CD180 target the translation machinery through mTOR independent as well as mTOR dependent pathways. Moreover, both these receptors transmit pro-survival signals via Akt-mediated inhibition of GSK3β and FOXO1/FOXO3a. Unexpectedly, coligation CD150 and CD180 receptors on CLL B cells led to mutual inhibition of the Akt and MAPK pathways. While CD150 and CD180 coligation resulted in reduced phosphorylation of Akt, ERK1/2, c-Jun, RSK, p70S6K, S6RP, and 4E-BP; it led to complete blocking of mTOR and p38MAPK phosphorylation. At the same time coligation of CD150 and CD40 receptors did not result in Akt and MAPK inhibition. This suggests that combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed.
150 Mb/s wifi transmission over 50m large core diameter step index POF
Shi, Y.; Nieto Munoz, M.; Okonkwo, C.M.; Boom, van den H.P.A.; Tangdiongga, E.; Koonen, A.M.J.
2011-01-01
We demonstrate successful transmission of WiFi signals over 50m step-index plastic optical fibre with 1mm core diameter employing an eye-safe resonant cavity light emitting diode and an avalanche photodetector. The EVM performance of 4.1% at signal data rate of 150Mb/s is achieved.
International Nuclear Information System (INIS)
Jing Zhao; Gong Ling; Xie Congying; Zhang Li; Su Huafang; Deng Xia; Wu Shixiu
2009-01-01
Background and purpose: The purpose of our study is to examine the capacity of cetuximab to reverse radiation resistance and investigate molecular mechanisms in human radiation-resistant esophageal carcinoma cell line KYSE-150R. Materials and methods: The radioresistant cell line KYSE-150R was established by using fractionated irradiation (FIR). The KYSE-150R cell line was exposed to radiation, treatment with cetuximab, and combined treatment. Cell cycle distribution and apoptosis were analyzed using flow cytometry. Radiation survival was analyzed using clonogenic assays. RT 2 profiler TM PCR array was performed to analyze EGF/PDGF signaling pathway genes. Results: The established esophageal carcinoma cell line KYSE-150R showed higher radioresistance than parental cell line. Cetuximab could reverse the radiation resistance of KYSE-150R cells. Cell cycle analysis showed that combination with radiation and cetuximab resulted in the accumulation of cells in G1 and G2/M phases, with the reduction of cells within the S phase. Cetuximab enhanced the apoptosis induced by radiation. RT 2 profiler TM array showed that some intracellular signaling genes deriving from EGF/PDGF signaling pathway regulated by cetuximab. Conclusions: Irradiation combined with EGFR blocked by cetuximab may reverse the resistance to radiation in radioresistant esophageal carcinoma cell. The mechanisms may include cell cycle perturbation and enhancement of radiation-induced apoptosis. Further studies are needed to evaluate the role of cetuximab in combination with radiotherapy in the management of esophageal carcinoma.
International Nuclear Information System (INIS)
Boutiche, M.
1995-01-01
Chemical interactions between electrolytic solutions commonly used i drilling muds and clays have been studies under P-T conditions similar to those of drillings (150 deg C) in order to determine the eventual consequences on the stability of clay rich formations. The experimental work has been carried out using several solutions (water, NaOH (pH 8, 10, 12), KCI (0,1, 1 2 mol./l), sea water, and K 2 CO 3 ) and clay minerals with low to high amounts of swelling layers (smectite (Na, Na-Ca, Ca), mixed layered illite-smectite minerals). Run products are studied by X-ray diffraction and electronic microprobe. Smectite layers show series of mineralogical changes (cation exchange in the interlayer site, formation of non-swelling layers, hydrolysis), which, however, do not yield to the formation of new minerals, except in the case of the interaction with K 2 CO 3 at 150 deg C (zeolite crystallisation). Cation exchange in the interlayer depends on the nature of the cation, cation concentration in the solution, exchange constants, and liquid/solid ratio. In dilute solutions ( 1 mol./l), because they favour the collapse of swelling layers, and dispersion. Solutions of K 2 CO 3 at 150 deg C are at the origin of the transformation of smectite to zeolites, and high pH - highly saline solutions are rather aggressive, and would probably not stabilize the argilites. (author)
The double beta decay spectra of 82Se, 100Mo, and 150Nd
International Nuclear Information System (INIS)
Nelson, M.A.; Moe, M.K.; Vient, M.A.; Elliott, S.R.
1992-01-01
The double beta decay electron energy spectra of 82 Se, 100 Mo, and 150 Nd have been measured with a time projection chamber, and departures from the expected two-neutrino spectral shapes have been observed. Efforts to reduce possible background contamination have been made, and tests are now being done in an effort to determine whether the anomalous signals are real effects, or simply experimental artifacts
Sapteka, A. A. N. G.; Narottama, A. A. N. M.; Winarta, A.; Amerta Yasa, K.; Priambodo, P. S.; Putra, N.
2018-01-01
Solar energy utilized with solar panel is a renewable energy that needs to be studied further. The site nearest to the equator, it is not surprising, receives the highest solar energy. In this paper, a modelling of electrical characteristics of 150-Watt peak solar panels using Boltzmann sigmoid function under various temperature and irradiance is reported. Current, voltage, temperature and irradiance data in Denpasar, a city located at just south of equator, was collected. Solar power meter is used to measure irradiance level, meanwhile digital thermometer is used to measure temperature of front and back panels. Short circuit current and open circuit voltage data was also collected at different temperature and irradiance level. Statistically, the electrical characteristics of 150-Watt peak solar panel can be modelled using Boltzmann sigmoid function with good fit. Therefore, it can be concluded that Boltzmann sigmoid function might be used to determine current and voltage characteristics of 150-Watt peak solar panel under various temperature and irradiance.
International Nuclear Information System (INIS)
Yasumune, Takashi; Takayama, Nobuyasu; Maehata, Keisuke; Ishibashi, Kenji; Umeno, Takahiro
2008-01-01
In this work, the direct-bandgap compound semiconductor materials are irradiated by α particles emitted from 241 Am for the detection of scintillation light at the temperature of 150 mK. For the irradiation experiment, two disk shaped samples were fabricated from an epoxy resin mixed with the powder of PbI 2 and CuI, respectively. Each disk-samples was cooled down to 150 mK by a compact liquid helium-free dilution refrigerator. A Si avalanche photodiode (APD) was employed for detecting the scintillation light emitted from the disk-sample inside the refrigerator. The detection signal current of Si APD was converted into the voltage pulses by a charge sensitive preamplifier. The voltage pulses of the scintillation light emitted from the direct-bandgap semiconductors were observed at the temperature of 150 mK. (author)
PERSPECTIVES OF MODERNIZATION OF WIRE MILL OF HOT ROLLING 150 AT RUP “BMZ”
Directory of Open Access Journals (Sweden)
A. V. Gontarj
2004-01-01
Full Text Available The offered modernization of the mill presumes the increase of capacity of the small-sort wire mill of hot milling 150 approximately till 40% at reduction of cost of the produced on it rolled wire by 15%, that will allow in future as well to grow the volumes of hardware production.
Superdeformation in the A=150 and A=190 regions
International Nuclear Information System (INIS)
Carpenter, M. P.
1998-01-01
Superdeformation has been established for over a decade in the mass 150 region and nearly as long in the A=190 region. The first measurements directed at nuclei in these regions concentrated on mapping out the superdeformed (SD) islands by identifying SD rotational bands in γ-ray coincidence data. These early studies provided new insights into the physics of superdeformation, but also raised unexpected issues. The new gamma-ray arrays (Gammasphere, Eurogam/Euroball and Gasp) have provided a wealth of new data on properties of SD states in these two mass regions. This paper highlights some of the more recent results from the large arrays which have addressed the outstanding issues in the field, namely, ΔI = 4 staggering, identical bands, SD vibrational bands, and questions about the feeding into and the decay out of the SD well
Study of 150 cases of acute appendicitis in children
Directory of Open Access Journals (Sweden)
Fallahi Gh
1998-06-01
Full Text Available Acute appendicitis is the most common condidition, requiring emergency operation in children. Late appendicitis is still a major sours of morbidity and potential mortality. The charts of all pediatric appendectomy patients (150 cases treated between 1367-1373 (Iranian calender in Amir Kabir Medical Center were reviewed. Mean hospital stay was 4.7 days. Mean ages of patients was 8.5 years. Male to female ratio was 1.2/1. Most common symptom was abdominal pain (100% and deep tenderness in right lower quadrant in 94.6%. Mean temprature was 37.2 and leucocytosis (more than 10000 were in the 76.3%. 14 patients had perforated appendicitis and most common pathology was acut supporative appendicitis. Accuracy of diagnosis was 96.6% and post operative pelvic abccess was 2%. Mortality occurred in one case (0.6%
Superdeformation in the A=150 and A=190 regions.
Energy Technology Data Exchange (ETDEWEB)
Carpenter, M. P.
1998-12-01
Superdeformation has been established for over a decade in the mass 150 region and nearly as long in the A=190 region. The first measurements directed at nuclei in these regions concentrated on mapping out the superdeformed (SD) islands by identifying SD rotational bands in {gamma}-ray coincidence data. These early studies provided new insights into the physics of superdeformation, but also raised unexpected issues. The new gamma-ray arrays (Gammasphere, Eurogam/Euroball and Gasp) have provided a wealth of new data on properties of SD states in these two mass regions. This paper highlights some of the more recent results from the large arrays which have addressed the outstanding issues in the field, namely, {Delta}I = 4 staggering, identical bands, SD vibrational bands, and questions about the feeding into and the decay out of the SD well.
An operational 150 kV microfocus rod anode X-ray system for nondestructive testing
International Nuclear Information System (INIS)
Fontijn, E.A.
1978-01-01
This paper describes an operational state of the art 150 kV microfocus rod anode X-ray system having ultra-high radiographic resolution capabilities. A cocal spot size of 0.050 mm is provided. Heretofore unattainable long rod anode lengths coupled with very small diameters are now possible using mini-magnetic lens technology. Over-all rod anode diameters as small as 9 mm with useful lengths of 1 m or more are possible, permitting panoramic inspections where previously only lower resolution radioisotope radiographic techniques were possible. Radiographic sensitivity of better than 1% has been reported with film-focal-distances on the order of 8 mm through 3 mm of steel. The system has been successfully applied to steam generator and heat exchanger tube-to-tubesheet weldments in both Europe and the USA. Other application areas include marine and aircraft jet engine inspection and numerous other applications where high reliability requirements indicate the use of a ultra-sensitive radiographic technique as is routinely demonstrated with the 150 kV Microfocus Rod Anode X-ray System. (orig.) [de
Luminescent determination of trace amounts of terbium using diantipyrylmethane and salicylic acid
Energy Technology Data Exchange (ETDEWEB)
Tishchenko, M A; Gerasimenko, G I; Poluehktov, N S [AN Ukrainskoj SSR, Odessa. Inst. Obshchej i Neorganicheskoj Khimii
1978-01-01
To elucidate the possibility of using pyrazolone-5-diantipyril-methane (DAM) derivative for determination of terbium microimpurities, the conditions have been studied of luminescent determination of terbium in complex compounds containing an ion of rare-earth element, diantipyrilmethane, and salicylic acid (Sal.). The ratio between the components in the complex REE-DAM-Sal is 1:1:3. La, Y, Gd do not affect the luminescence intensity of terbium complex. A luminescent method of determining terbium traces in highly pure oxides of lanthanum, gadolinium, lutetium, and yttrium has been developed in which suspensions of complex precipitation are used. The amount of terbium determined in oxide of lanthanum, gadolinium, and lutetium is (1-5)x10/sup -6/% and (2-3)x10/sup -5/% in yttrium oxide.
Analysis of AC and DC Lighting Systems with 150-Watt Peak Solar Panel in Denpasar Based on NASA Data
Narottama, A. A. N. M.; Amerta Yasa, K.; Suwardana, I. W.; Sapteka, A. A. N. G.; Priambodo, P. S.
2018-01-01
Solar energy on the Earth’s surface has different magnitudes on every longitude and latitude. National Aeronautics and Space Administration (NASA) provides surface meteorology and solar energy database which can be accessed openly online. This database delivers information about Monthly Averaged Insolation Incident On A Horizontal Surface, Monthly Averaged Insolation Incident On A Horizontal Surface At Indicated GMT Times and also data about Equivalent Number Of No-Sun Or Black Days for any latitude and longitude. Therefore, we investigate the lighting systems with 150-Watt peak solar panel in Denpasar City, the capital province of Bali. Based on NASA data, we analyse the received wattage by a unit of 150-Watt peak solar panel in Denpasar City and the sustainability of 150-Watt peak solar panel to supply energy for 432-Watt hour/day AC and 360-Watt hour/day DC lighting systems using 1.2 kWh battery. The result shows that the maximum received wattage by a unit of 150-Watt peak solar panel is 0.76 kW/day in October. We concluded that the 1.2 kWh installed battery has higher capacity than the battery capacity needed in March, the month with highest no-sun days, for both AC and DC lighting systems. We calculate that the installed battery can be used to store the sustainable energy from sun needed by AC and DC lighting system for about 2.78 days and 3.51 days, consecutively.
SPS Injection and Beam Quality for LHC Heavy Ions With 150 ns Kicker Rise Time
Goddard, Brennan; Ducimetière, Laurent; Kotzian, Gerd; Uythoven, Jan; Velotti, Francesco
2016-01-01
As part of the LHC Injectors Upgrade project for LHC heavy ions, the SPS injection kicker system rise time needs reduction below its present 225 ns. One technically challenging option under consideration is the addition of fast Pulse Forming Lines in parallel to the existing Pulse Forming Networks for the 12 kicker magnets MKP-S, targeting a system field rise time of 100 ns. An alternative option is to optimise the system to approach the existing individual magnet field rise time (2-98%) of 150 ns. This would still significantly increase the number of colliding bunches in LHC while minimising the cost and effort of the system upgrade. The observed characteristics of the present system are described, compared to the expected system rise time, together with results of simulations and measurements with 175 and 150 ns injection batch spacing. The expected beam quality at injection into LHC is quantified, with the emittance growth and simulated tail population taking into account expected jitter and synchronisatio...
International Nuclear Information System (INIS)
Calzada, V.
2011-01-01
This Master thesis presented at the University of the Oriental Republic of Uruguay, School of Chemistry studies the following topics: quality control in nuclear medicine, radiopharmaceuticals such as technetium and lutetium
Measurement and Evaluation of the Activation Resonance Integral of 146Nd, 148Nd and 150Nd
International Nuclear Information System (INIS)
Ricabarra, M. D.; Turjanski, R.; Ricabarra, G. H.
2012-01-01
Values of the ratio of the reduced activation resonance integral to the thermal cross section, I'/σ 0 of 146 Nd, 148 Nd and 150 Nd were determined relative to gold by measuring cadmium ratios. A lithium-drifted germanium gamma ray spectrometer was used to resolve the activities of the irradiated samples. The results are for 146 Nd I'/σ 0 = 1.42±0.1 0 and with an assumed σ 0 = 1.4 barn, I' = 1 .99±0.20; for 148 Nd I'/ σ 0 = 4.22±0.1 4 and with an assumed σ 0 = 2.5 barn, I' = 10.5±0. 9 barn, and for 150 Nd I'/σ 0 = 13.7±0. 8 and with an assumed σ 0 = 1.2 barn, I' = 16.4±2.8. The resolved and unresolved epithermal integrals of 146 Nd, 148 Nd and 150 Nd were calculated. Values of the spectral correction factor were also calculated, so the resonance integral could be obtained from the epithermal integral data measured in our reactor spectrum in this experiment. Epithermal integral and spectral correction factors are listed in the text. The most important result of this investigation is that the 148 Nd activation reduced resonance integral is about half of the previously recommended value and consequently the radiative width for 148 Nd is also about half of the previously accepted value. (author)
Energy Technology Data Exchange (ETDEWEB)
Li, G; Nishino, T [UT MD Anderson Cancer Center, Houston, TX (United States); Greene, T [Radiation Services, Inc., Dover, FL (United States); Willis, C [MD Anderson Cancer Center, Bellaire, TX (United States)
2015-06-15
Purpose: To determine the consistency of digital detector (DR) tests recommended by AAPM TG150 and tests provided by commercially available DirectView Total Quality Tool (TQT). Methods: The DR tests recommended by the TG150 Detector Subgroup[1] were performed on 4 new Carestream DRX-Revolution and one Carestream DRX1C retrofit of a GE AMX-4 that had been in service for three years. After detector calibration, flat-field images plus images of two bar patterns oriented parallel and perpendicular to the A-C axis, were acquired at conditions recommended by TG150. Raw images were harvested and then analyzed using a MATLAB software previously validated[2,3,4]. Data were analyzed using ROIs of two different dimensions: 1) 128 x 128 ROIs matching the detector electronics; and 2) 256 x 256 ROIs, each including 4 adjacent smaller ROIs. TG150 metrics from 128 x 128 ROIs were compared to TQT metrics, which are also obtained from 128 x 128 ROIs[5]. Results: The results show that both TG150 and TQT measurements were consistent among these detectors. Differences between TG150 and TQT values appear systematic. Compared with 128 x 128 ROIs, noise and SNR non-uniformity were lower with 256 x 256 ROIs, although signal non-uniformity was similar, indicating detectors were appropriately calibrated for gain and offset. MTF of the retrofit unit remained essentially the same between 2012 and 2015, but was inferior to the new units. The older generator focal spot is smaller (0.75mm vs. 1.2mm), and the SID for acquisition is 182cm as well, so focal spot dimensions cannot explain the difference. The difference in MTF may be secondary to differences in generator X-ray spectrum or by unannounced changes in detector architecture. Further investigation is needed. Conclusion: The study shows that both TG150 and TQT tests are consistent. The numerical value of some metrics are dependent on ROI size.
Superdeformation in the A=150 and A=190 regions
International Nuclear Information System (INIS)
Carpenter, M. P.; Janssens, R. V. F.
1999-01-01
Superdeformation has been established for over a decade in the mass 150 region and nearly as long in the A=190 region. The first measurements directed at nuclei in these regions concentrated on mapping out the superdeformed (SD) islands by identifying SD rotational bands in γ-ray coincidence data. These early studies provided new insights into the physics of superdeformation, but also raised unexpected issues. The new gamma-ray arrays (Gammasphere, Eurogam/Euroball and Gasp) have provided a wealth of new data on properties of SD states in these two mass regions. This paper highlights some of the more recent results from the large arrays which have addressed the outstanding issues in the field, namely, ΔI=4 staggering, identical bands, SD vibrational bands, and questions about the feeding into and the decay out of the SD well. (c) 1999 American Institute of Physics
Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.
Teo, Adrian Kee Keong; Kulkarni, Rohit N
2012-10-17
Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.
Raber-Durlacher, J. E.; Weijl, N. I.; Abu Saris, M.; de Koning, B.; Zwinderman, A. H.; Osanto, S.
2000-01-01
The incidence and the severity of chemotherapy-associated oral mucositis were determined in a retrospective analysis of 150 patients with various solid tumors. In addition, possible risk factors for the development of mucositis were identified. Patients were treated with chemotherapeutic regimens
Directory of Open Access Journals (Sweden)
Lisette Martínez Miranda
2004-08-01
Full Text Available Dentro del proceso global de la liberación de un fármaco, la disolución constituye el paso más importante pues se encuentra íntimamente relacionada con los procesos de absorción, determinantes en la biodisponibilidad de un medicamento administrado por vía oral. En el presente trabajo se realizaron los perfiles de disolución de 3 lotes de Zantac® (GlaxoWellcome, medicamento líder del principio activo ranitidina (DCI y de 3 lotes de ranitidina 150 mg de producción nacional. Para el estudio de disolución se utilizó el método descrito en la USP 23. Los datos de porcentaje de principio activo liberado contra tiempo fueron sometidos a un estudio de ajuste a 4 modelos comunes a perfiles de disolución mediante el programa CurveExpert. Todos los lotes estudiados cumplen con los criterios de la Food and Drug Administration (FDA para los estudios de bioequivalencia in vitro.Dissolution is the most important step in the global release process of a drug , since it is closely related to the absorption processes, which are determinant in the bioavailability of a drug administered by oral route. The dissolution profiles of 3 batches of Zantac® (Glaxo Wellcome, a leading drug of the ranitidine active principle (DCI, and of 3 batches of ranitidine 150 mg of national production were performed. The method described in the USP 23 was used for the dissolution test. The percentage data of the active principle released against time were subjected to a study of adjustment of 4 models to common disssolution profiles by the CurveExpert program. All the studied batches fulfilled the criteria of the Food and Drug Administration (FDA for the in vitro bioequivalence studies.
Kuusk, Priit, 1938-
2002-01-01
Wagneri ooperite "Festtage" Berliinis. Lihavõtteaegu toimunud kontsertidest Luzernis, Viinis, Salzburgis, Hamburgis ja Londonis. Soome ooperiloo esimesest ooperist Fredrik Paciuse "Kuningas Karli jahiretk" sünnist on möödunud 150
33 CFR 150.628 - How must the operator label, tag, and mark a container of hazardous material?
2010-07-01
... Workplace Safety and Health Hazard Communication Program § 150.628 How must the operator label, tag, and..., reactive and other special condition hazard warnings. The only exception is for portable containers that...
CFD simulation of combustion in a 150 MW{sub e} CFB boiler
Energy Technology Data Exchange (ETDEWEB)
Zhang, Nan; Wang, Wei; Li, Jinghai [Chinese Academy of Sciences, Beijing (China). State Key Lab. of Multiphase Complex Systems
2013-07-01
Eulerian granular multiphase model with meso-scale modeling of drag coefficient and mass transfer coefficient, based on the energy minimization multi-scale (EMMS) model, was presented to simulate a 150 MW{sub e} CFB boiler. The three-dimensional (3D), time-dependent simulation results were presented in terms of the profiles of pressure, the distributions of carbon and oxygen, as well as the temperature. The EMMS-based sub-grid modeling allows using coarse grid with proven accuracy, and hence it is suitable for simulation of such large-scale industrial reactors.
DEFF Research Database (Denmark)
Stroes, Erik; Guyton, John R; Lepor, Norman
2016-01-01
controlled hypercholesterolemia and not on statin (majority with statin-associated muscle symptoms), receiving treatment with fenofibrate, ezetimibe, or diet alone. METHODS AND RESULTS: Patients were randomly assigned to placebo, alirocumab 150 mg Q4W or 75 mg Q2W (calibrator arm), with dose adjustment......: Alirocumab 150 mg Q4W can be considered in patients not on statin with inadequately controlled hypercholesterolemia as a convenient option for lowering LDL-C. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02023879....
The Barley Magnesium Chelatase 150-kD Subunit Is Not an Abscisic Acid Receptor1[OA
Müller, André H.; Hansson, Mats
2009-01-01
Magnesium chelatase is the first unique enzyme of the chlorophyll biosynthetic pathway. It is composed of three gene products of which the largest is 150 kD. This protein was recently identified as an abscisic acid receptor in Arabidopsis (Arabidopsis thaliana). We have evaluated whether the barley (Hordeum vulgare) magnesium chelatase large subunit, XanF, could be a receptor for the phytohormone. The study involved analysis of recombinant magnesium chelatase protein as well as several induced chlorophyll-deficient magnesium chelatase mutants with defects identified at the gene and protein levels. Abscisic acid had no effect on magnesium chelatase activity and binding to the barley 150-kD protein could not be shown. Magnesium chelatase mutants showed a wild-type response in respect to postgermination growth and stomatal aperture. Our results question the function of the large magnesium chelatase subunit as an abscisic acid receptor. PMID:19176716
150th Anniversary of the Astronomical Observatory Library of Sciences
Solntseva, T.
The scientific library of the Astronomical observatory of Kyiv Taras Shevchenko University is one of the oldest ones of such a type in Ukraine. Our Astronomical Observatory and its scientific library will celebrate 150th anniversary of their foundation. 900 volumes of duplicates of Olbers' private library underlay our library. These ones were acquired by Russian Academy of Sciences for Poulkovo observatory in 1841 but according to Struve's order were transmitted to Kyiv Saint Volodymyr University. These books are of great value. There are works edited during Copernicus', Kepler's, Galilei's, Newton's, Descartes' lifetime. Our library contains more than 100000 units of storage - monographs, periodical astronomical editions from the first (Astronomische Nachrichten, Astronomical journal, Monthly Notices etc.), editions of the majority of the astronomical observatories and institutions of the world, unique astronomical atlases and maps
Microscopic study of superdeformation in the A = 150 mass region
Energy Technology Data Exchange (ETDEWEB)
Rigollet, C.; Gall, B. [CNRS, Strasbourg (France); Bonche, P. [CEN Saclay, Gif sur Yvette (France)] [and others
1996-12-31
The authors are presently investigating the properties of superdeformed (SD) nuclear states in the A=150 mass region. For that purpose, they use the cranked HFB method in which pairing correlations are treated dynamically by means of the Lipkin-Nogami prescription. Their goal is to take advantage of the large amount of experimental data to test the predictive power of their microscopic approach and of the effective interaction. In the present communication, they focus on {sup 152}Dy and {sup 153}Dy for which there are recent experimental data. In particular lifetime measurements have allowed to extract electric quadrupole moments. The new Skyrme effective force SLy4 is used to describe the nucleon-nucleon interaction, while for the pairing channel the authors use a density-dependent zero-range interaction.
Jung, T.W.; Lee, K.T.; Lee, M.W.; Ka, K.H.
2012-01-01
Endoplasmic reticulum (ER) stress has been implicated in the pathology of type 2 diabetes mellitus (T2DM). Although SIRT1 has a therapeutic effect on T2DM, the mechanisms by which SIRT1 ameliorates insulin resistance (IR) remain unclear. In this study, we investigated the impact of SIRT1 on palmitate-induced ER stress in HepG2 cells and its underlying signal pathway. Treatment with resveratrol, a SIRT1 activator significantly inhibited palmitate-induced ER stress, leading to the protection against palmitate-induced ER stress and insulin resistance. Resveratrol and SIRT1 overexpression induced the expression of oxygen-regulated protein (ORP) 150 in HepG2 cells. Forkhead box O1 (FOXO1) was involved in the regulation of ORP150 expression because suppression of FOXO1 inhibited the induction of ORP150 by SIRT1. Our results indicate a novel mechanism by which SIRT1 regulates ER stress by overexpression of ORP150, and suggest that SIRT1 ameliorates palmitate-induced insulin resistance in HepG2 cells via regulation of ER stress.
The joint PNC-ORNL tank calibration experiment of 1991
International Nuclear Information System (INIS)
Smith, D.H.; Bostick, D.A.; McBay, E.H.; Carter, J.A.; Ehinger, M.H.
1991-11-01
A tank calibration experiment was carried out using the lutetium double spike technique as part of the joint PNC-DOE effort to establish nuclear safeguards at reprocessing plants. The experiment used a 3000 liter tank containing about 100g/L depleted uranium. Results were less than ideal, but the reasons for this are understood. The discussions between the two organizations were highly beneficial. The experiment served to identify two problems in the procedure that must be solved before anything else is tried: 1. Quantitative mixing of tracer of tank contents has not been achieved at PNC. This must be corrected. 2. A chemical procedure to isolate lutetium in a form compatible with good mass spectrometric analysis must be developed. It must be amenable to use in a hot cell. 6 refs., 6 figs., 2 tabs
Laser melting of groove defect repair on high thermal conductivity steel (HTCS-150)
Norhafzan, B.; Aqida, S. N.; Fazliana, F.; Reza, M. S.; Ismail, I.; Khairil, C. M.
2018-02-01
This paper presents laser melting repair of groove defect on HTCS-150 surface using Nd:YAG laser system. Laser melting process was conducted using JK300HPS Nd:YAG twin lamp laser source with 1064 nm wavelength and pulsed mode. The parameters are pulse repetition frequency (PRF) that is set from 70 to 100 Hz, average power ( P A) of 50-70 W, and laser spot size of 0.7 mm. HTCS-150 samples were prepared with groove dimension of 0.3 mm width and depths of 0.5 mm using EDM wire cut. Groove defect repaired using laser melting process on groove surface area with various parameters' process. The melted surface within the groove was characterized for subsurface hardness profile, roughness, phase identification, chemical composition, and metallographic study. The roughness analysis indicates high PRF at large spot size caused high surface roughness and low surface hardness. Grain refinement of repaired layer was analyzed within the groove as a result of rapid heating and cooling. The hardness properties of modified HTCS inside the groove and the bulk surface increased two times from as received HTCS due to grain refinement which is in agreement with Hall-Petch equation. These findings are significant to parameter design of die repair for optimum surface integrity and potential for repairing crack depth and width of less than 0.5 and 0.3 mm, respectively.
van Lith, Sanne A M; Roodink, Ilse; Verhoeff, Joost J C; Mäkinen, Petri I; Lappalainen, Jari P; Ylä-Herttuala, Seppo; Raats, Jos; van Wijk, Erwin; Roepman, Ronald; Letteboer, Stef J; Verrijp, Kiek; Leenders, William P J
2016-11-01
Diffuse gliomas are primary brain cancers that are characterised by infiltrative growth. Whereas high-grade glioma characteristically presents with perinecrotic neovascularisation, large tumor areas thrive on pre-existent vasculature as well. Clinical studies have revealed that pharmacological inhibition of the angiogenic process does not improve survival of glioblastoma patients. Direct targeting of tumor vessels may however still be an interesting therapeutic approach as it allows pinching off the blood supply to tumor cells. Such tumor vessel targeting requires the identification of tumor-specific vascular targeting agents (TVTAs).Here we describe a novel TVTA, C-C7, which we identified via in vivo biopanning of a llama nanobody phage display library in an orthotopic mouse model of diffuse glioma. We show that C-C7 recognizes a subpopulation of tumor blood vessels in glioma xenografts and clinical glioma samples. Additionally, C-C7 recognizes macrophages and activated endothelial cells in atherosclerotic lesions. By using C-C7 as bait in yeast-2-hybrid (Y2H) screens we identified dynactin-1-p150Glued as its binding partner. The interaction was confirmed by co-immunostainings with C-C7 and a commercial anti-dynactin-1-p150Glued antibody, and via co-immunoprecipitation/western blot studies. Normal brain vessels do not express dynactin-1-p150Glued and its expression is reduced under anti-VEGF therapy, suggesting that dynactin-1-p150Glued is a marker for activated endothelial cells.In conclusion, we show that in vivo phage display combined with Y2H screenings provides a powerful approach to identify tumor-targeting nanobodies and their binding partners. Using this combination of methods we identify dynactin-1-p150Glued as a novel targetable protein on activated endothelial cells and macrophages.
2010-10-01
... arrangements are unavailable. (b) Refusal to work when an acceptable form of child care is available is not... penalized because a parent refuses to work because (s)he cannot find child care? 286.150 Section 286.150... a parent refuses to work because (s)he cannot find child care? (a) If the individual is a single...
Utilization of new 150-MeV neutron and proton evaluations in MCNP
International Nuclear Information System (INIS)
Little, R.C.; Frankle, S.C.; Hughes, H.G. III; Prael, R.E.
1997-01-01
MCNP trademark and LAHET trademark are two of the codes included in the LARAMIE (Los Alamos Radiation Modeling Interactive Environment) code system. Both MCNP and LAHET are three-dimensional continuous-energy Monte Carlo radiation transport codes. The capabilities of MCNP and LAHET are currently being merged into one code for the Accelerator Production of Tritium (APT) program at Los Alamos National Laboratory. Concurrently, a significant effort is underway to improve the accuracy of the physics in the merged code. In particular, full nuclear-data evaluations (in ENDF6 format) for many materials of importance to APT are being produced for incident neutrons and protons up to an energy of 150-MeV. After processing, cross-section tables based on these new evaluations will be available for use fin the merged code. In order to utilize these new cross-section tables, significant enhancements are required for the merged code. Neutron cross-section tables for MCNP currently specify emission data for neutrons and photons only; the new evaluations also include complete neutron-induced data for protons, deuterons, tritons, and alphas. In addition, no provision in either MCNP or LAHET currently exists for the use of incident charged-particle tables other than for electrons. To accommodate the new neutron-induced data, it was first necessary to expand the format definition of an MCNP neutron cross-section table. The authors have prepared a 150-MeV neutron cross-section library in this expanded format for 15 nuclides. Modifications to MCNP have been implemented so that this expanded neutron library can be utilized
Properties of PZT-Based Piezoelectric Ceramics Between -150 and 250 C
Hooker, Matthew W.
1998-01-01
The properties of three PZT-based piezoelectric ceramics and one PLZT electrostrictive ceramic were measured as a function of temperature. In this work, the dielectric, ferroelectric polarization versus electric field, and piezoelectric properties of PZT-4, PZT-5A, PZT-5H, and PLZT-9/65/35 were measured over a temperature range of -150 to 250 C. In addition to these measurements, the relative thermal expansion of each composition was measured from 25 to 600 C and the modulus of rupture of each material was measured at room temperature. This report describes the experimental results and compares and contrasts the properties of these materials with respect to their applicability to intelligent aerospace systems.
Czech Academy of Sciences Publication Activity Database
Guzik, M.; Pejchal, Jan; Yoshikawa, A.; Ito, A.; Goto, T.; Siczek, M.; Lis, T.; Boulon, J.
2014-01-01
Roč. 14, č. 7 (2014), 3327 -3334 ISSN 1528-7483 Institutional support: RVO:68378271 Keywords : lutetium oxide * structure * crystal growth * ceramics Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 4.891, year: 2014
International Nuclear Information System (INIS)
Caurel, J.
1990-01-01
The glass R7T7 is chosen in France for vitrification of solution from reprocessing. Safety requires the knowledge of R7T7 long term behavior in deep geologic formations. Temperature dependence of leaching between 50 and 300 0 C is studied by static tests for 7 days. An activation energy of 30kJ/Mole is calculated between 50; 75 or 100 0 C and 250 0 C. Results suggest similar corrosion mechanisms between 90-100 and 250 0 C by a complete change between 250 and 275 0 C. Glass corrosion kinetics at 150 0 C and 250 0 C between 1 day and 1 year evidence the precipitation of aluminosilicates and formation of thick amorphous gels progressively enriched with silica. Glass dissolution at 150 0 C and 250 0 C is simulated with the geochemical DISSOL code. Results suggest that dissolution kinetics are controlled by activity of H 4 SiO 4 in solution only. Silica contained into the gel controls corrosion kinetics different from 0. Even if the nature of dissolution mechanisms does not seem modified between 150 and 250 0 C, sample cracking at 250 0 C induces an increase of dissolved glass that does not allow a direct comparison of corrosion kinetics between 150 and 250 0 C [fr
Walukow, Stephy B.; Manjang, Salama; Zainuddin, Zahir; Samman, Faizal Arya
2018-03-01
This research is to analyze design of ceramic and polymer 150 kV insulators for the tropical area. The use of an insulator certainly requires an electric field. The leakage current and breakdown voltage this happens the contaminant on the surface of the insulator. This type of contaminant can be rain, dust, salt air, extreme weather (much in tropical climates), industrial pollutants and cracks on the surface resulting in collisions. The method used in this research is magnetic field and electric field isolator using Quicfield software. To get the test results variation ranges 20 kV, 70 kV and 150 kV. Side effects of magnetic and electric fields around the insulator. The simulation results show the accumulated contaminants on the surface. Planning should be done in insulator insulator on unstable insulator. Thus, the approach using this commercially available software can be applied to. Therefore, the development of further simulations on the different types of composite insulators used on.
Free electron laser facilities employing a 150-MeV linac injector for Saga synchrotron light source
International Nuclear Information System (INIS)
Tomimasu, T.; Yasumoto, M.; Ochiai, Y.; Ishibashi, M.; Murayama, T.
1999-01-01
Free electron laser (FEL) facilities as the FELI FEL Facility are proposed, for which a 150-MeV linac type injector for a Saga synchrotron light source (SLS) is employed in FEL mode. The linac has two operating modes; short macropulse mode a 1 μs at 150 MeV for injection to a 1 - 1.3-GeV third generation type storage ring and long macropulse mode of 12 μs at 100 MeV for four FEL Facilities. The macropulse beam consists of a train of several ps, 0.6 nC microbunches (peak current 100 A) repeating at 89.25 MHz. We are aiming to supply high power level photon beams covering an attractive wavelength range from 0.05 nm (25 keV) to 200 μm (0.006 eV) for scientific researches, bio-medical and industrial applications, using the Saga third generation type SLS with a superconducting wiggler and the proposed four FEL Facilities. (author)
Energy loss of 107Ag, 109Ag and 150Sm in Ni and Au
International Nuclear Information System (INIS)
Ribas, R.V.; Seale, W.A.; Roney, W.M.; Szanto, E.M.
1979-01-01
The stopping power of 107 Ag, 109 Ag and 150 Sm in nickel and gold was measured as a preliminary test of a new technique for measuring energy loss based on the γ-ray Dopppler shift. The analysis of the data was based on the theories of Lindhard, Scharff and Schiott for nuclear and electronic stopping. The results are compared with the semi-empirical predictions of Northcliffe and Schilling. (author) [pt
Experimental J/psi hadronic production from 150 to 280 GeV/c
International Nuclear Information System (INIS)
Burgun, G.; Charpentier, P.; Gandois, B.; Le Du, P.; Rahal, G.; Siegrist, P.; Hagelberg, R.; Hansroul, M.; Kienzle, W.; Michelini, A.; Runolfsson, O.; Timmermans, J.; Crozon, M.; Delpierre, P.; Leray, T.; Maillard, J.; Tilquin, A.; Valentin, J.; Boucrot, J.; Callot, O.; Decamp, D.; Lefrancois, J.
1983-01-01
A detailed study of J/psi hadronic production has been performed in a high statistics experiment (more than 1.5 10 6 J/psi observed in their dimuon decay mode). Data have been taken with incident πsup(+-), Ksup(+-), psup(+-), on hydrogen and platinum targets, at 150, 200 and 280 GeV/c. We find from the observed nuclear dependance of the cross sections, that about 18% of the J/psi are produced diffractively. Using known structure functions of the quarks in the nucleon and in the pion, we derive estimations for the gluon structure functions. (orig.)
Energy Technology Data Exchange (ETDEWEB)
Fernandez R, E [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)
2008-07-01
The stability constants of La{sup 3+}, Pr{sup 3+}, Eu{sup 3+}, Er{sup 3+} and Lu{sup 3+} chloride complexes were determined in perchloric acid media using a liquid-liquid extraction method. The dinonyl napthalene sulfonic acid in n-heptane was used as extractant. The lanthanide (Ln) concentrations were measured by a radiochemical (Eu and Lu) and a spectrophotometric (La, Pr, and Er) methods. In the last method, xylenol orange was used for the determinations at ph 6. The stability constants of lanthanum, praseodymium, erbium and lutetium chloride complexes were determined in 2, 3 and 4 M ionic strength and europium in 1, 2 and 3 M, at 303 K. The fitting of experimental data to the equations for the calculation of the stability constants, was carry out considering both one chemical species (LnCl{sup 2+}) or two chemical species (LnCl{sup 2+} and LnCl{sub 2}{sup +}). The Specific Ion Interaction Theory was applied to the values of log {beta}{sup I}{sub Ln},{sub Cl} and the first stability constants at zero ionic strength were calculated by extrapolation. The same theory could not be applied to the log {beta}{sup I}{sub Ln},{sub 2Cl}, due to its low abundance and the values determined for the stability constants were similar. The distribution diagrams of the chemical species were obtained using the program MEDUSA and considering log {beta}{sup I}{sub Ln},{sub CI}, log {beta}{sup I}{sub Ln},{sub 2CI} values obtained in this work and the hydrolysis constants taken from the literature. The lanthanide chloride complexes are present in solution at specific conditions of ionic strength, concentration and in the absence of hydrolysis. The log {beta}{sup I}{sub Ln},{sub Cl} data were related to the charge density and the corresponding equations were obtained. These equations could be used to determine the stability constants along the lanthanide series. (Author)
DEFF Research Database (Denmark)
Ade, P. A. R.; Aghanim, N.; Arnaud, M.
2015-01-01
We present the results of approximately three years of observations of Planck Sunyaev-Zeldovich (SZ) sources with the Russian-Turkish 1.5m telescope (RTT150), as a part of the optical follow-up programme undertaken by the Planck collaboration. During this time period approximately 20% of all dark...
Luminescence and scintillation properties of rare-earth-doped LuF.sub.3./sub. scintillation crystals
Czech Academy of Sciences Publication Activity Database
Pejchal, Jan; Fukuda, K.; Kurosawa, S.; Yokota, Y.; Yoshikawa, A.
2015-01-01
Roč. 41, Mar SI (2015), s. 58-62 ISSN 0925-3467 Institutional support: RVO:68378271 Keywords : lutetium fluoride * scintillator * scintillator * VUV luminescence Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.183, year: 2015
Energy Technology Data Exchange (ETDEWEB)
Fallon, P.; Alderson, A.; Bentley, M.A.; Bruce, A.M.; Forsyth, P.D.; Howe, D.; Roberts, J.W.; Sharpey-Schafer, J.F.; Twin, P.J.; Beck, F.A.
1989-02-16
Rotational bands, characteristic of a superdeformed prolate shape (epsilon approx. = 0.6) and extending to above spin 60 Planck constant, have been observed in both /sup 150/Gd and /sup 151/Tb. The magnitudes of the moments of inertia I/sup (2)/ were found to vary with frequency and the variation greatly exceeded that seen in /sup 148,149/Gd and /sup 151,152/Dy. The differences in the I/sup (2)/'s are attributed to the occupation of particular high-N orbitals. Moreover, contrary to the previous examples the bands in both /sup 150/Gd and /sup 151/Tb de-excited at a much higher rotational frequency of Planck constant..omega.. approx. = 0.4 MeV and this may indicate that the pair gap extends to higher frequencies in /sup 150/Gd and /sup 151/Tb.
Neutron and gamma-ray spectra measurement on the model of the KS-150 reactor radial shielding
International Nuclear Information System (INIS)
Holman, M.; Hogel, J.; Marik, J.; Kovarik, K.; Franc, L.; Vespalec, R.
1977-01-01
A shortened model of the peripheral region of the KS-150 reactor core consisting of two rows of fuel elements and a reflector was constructed from the peripheral fuel elements of the KS-150 reactor core in an experiment on the TR-0 reactor. The mockup of the thermal shield (10 cm of steel), the pressure vessel (15 cm of steel) and the inner wall of the water biological shielding (2 cm of steel) of the KS-150 reactor were erected outside the TR-0 vessel. Fast neutron and gamma spectra were measured with a stilbene crystal scintillation spectrometer. The resonance neutron spectra were measured with 197 Au, 63 Cu and 23 Na resonance activation detectors. Fast neutron spectra inside the reactor were measured with a 10 mm diameter by 10 mm thick stilbene crystal spectrometer, outside the reactor with a 10 mm diameter by 10 mm thick and a 20 mm diameter by 20 mm thick stilbene crystal spectrometer. Neutron spectra in the energy regions of 1 eV to 3 keV and 0.6 MeV to 0.8 MeV were obtained on the core periphery, on the reflector half-thickness and in front of and behind the reactor thermal shield. Gamma spectra were obtained in front of and behind the thermal shield. It was found that the attenuation of neutron fluxes by the reflector and the thermal shield increased with increasing energy while gamma radiation attenuation decreased with increasing energy. It was not possible to obtain the neutron spectrum in the 10 to 600 keV energy range because suitable detection instrumentation was not available. (J.P.)
Spin wave eigenmodes in single and coupled sub-150 nm rectangular permalloy dots
Energy Technology Data Exchange (ETDEWEB)
Carlotti, G., E-mail: giovanni.carlotti@fisica.unipg.it; Madami, M. [Dipartimento di Fisica e Geologia, Università di Perugia, Perugia (Italy); Tacchi, S. [Istituto Officina dei Materiali del CNR (CNR-IOM), Dipartimento di Fisica e Geologia, Perugia (Italy); Gubbiotti, G.; Dey, H.; Csaba, G.; Porod, W. [Center for Nano Science and Technology, Department of Electrical Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States)
2015-05-07
We present the results of a Brillouin light scattering investigation of thermally excited spin wave eigenmodes in square arrays of either isolated rectangular dots of permalloy or twins of dipolarly coupled elements, placed side-by-side or head-to-tail. The nanodots, fabricated by e-beam lithography and lift-off, are 20 nm thick and have the major size D in the range between 90 nm and 150 nm. The experimental spectra show the presence of two main peaks, corresponding to modes localized either at the edges or in the center of the dots. Their frequency dependence on the dot size and on the interaction with adjacent elements has been measured and successfully interpreted on the basis of dynamical micromagnetic simulations. The latter enabled us also to describe the spatial profile of the eigenmodes, putting in evidence the effects induced by the dipolar interaction between coupled dots. In particular, in twinned dots the demagnetizing field is appreciably modified in proximity of the “internal edges” if compared to the “external” ones, leading to a splitting of the edge mode. These results can be relevant for the exploitation of sub-150 nm magnetic dots in new applications, such as magnonic metamaterials, bit-patterned storage media, and nano-magnetic logic devices.
2010-10-12
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Alabama Power Company; Project No. 349-150--Alabama Martin Dam Hydroelectric Project; Notice of Proposed Restricted Service List for a... the Martin Dam Hydroelectric Project. The Programmatic Agreement, when executed by the Commission, the...
Towards Superheavies: Spectroscopy of 94 < Z < 98, 150 < N < 154 Nuclei
Directory of Open Access Journals (Sweden)
Chowdhury P.
2016-01-01
nuclear structure studies are important testing grounds for theoretical models that aim to describe superheavy nuclei. To study the highest neutron orbitals (150 ≤ N ≤ 154, we have populated high angular momentum states in a series of Pu (Z = 94, Cm (Z = 96 and Cf (Z = 98 nuclei, via inelastic and transfer reactions, with heavy beams on long-lived radioactive actinide targets. Multiple collective excitation modes and structures were identified, and their configurations deduced. Quasiparticle alignments are mapped, with odd-A band structures helping identify specific orbital contributions via blocking arguments. Higher-order multipole shapes are observed to play a significant role in disentangling competing neutron and proton alignments. The N > 152 data provide new perspectives on physics beyond the N = 152 sub-shell gap.
Energy Technology Data Exchange (ETDEWEB)
Waliczek, Sven; Raddatz, Ulrich [Sandvik Mining and Construction Central Europe GmbH, Essen (Germany)
2010-09-15
Prince Herrmann Ludwig Heinrich von Pueckler-Muskau, a landscape gardening genius, built the Muskau Park in the Lusatia region in 1817 - it is part of a UNESCO world heritage site today. In the same era, 1850, the first lignite was mined in the region and still today, Vattenfall, the Swedish company, extracts lignite without subsidies - in Jaenschwalde among other places, one out of the five opencast mines currently in operation. As one of the largest employers and apprenticing companies in East Germany, Vattenfall currently employs almost 8000 employees and about 800 apprentices. Sandvik Mining and Construction also plays a leading role - in the literal sense. At the Jaenschwalde location there are 320 sets of 5-roller garlands of HM150 formed rollers in action on the overburden conveyor bridge AFB 60m (Figure 1) - on belt five, the main belt conveyor (belt type 3000 ST3000-18:8, idler spacing approx. 800 mm) and on belt eight, the stockpile belt conveyor (belt type 2750 ST2500-18:8, idler spacing approx. 800 mm). It all began in the spring of 2004. Bernhard Hofmayer, Production Manager at Sandvik, introduced the HM150 formed roller to Vattenfall. The engineers were impressed by the completely new design and the innovative assembly technique. The discussion about the advantages and disadvantages of the component optimised formed roller were ready to begin. (orig.)
A Wavelet-Modified ESPRIT Hybrid Method for Assessment of Spectral Components from 0 to 150 kHz
Directory of Open Access Journals (Sweden)
Luisa Alfieri
2017-01-01
Full Text Available Waveform distortions are an important issue in distribution systems. In particular, the assessment of very wide spectra, that include also components in the 2–150 kHz range, has recently become an issue of great interest. This is due to the increasing presence of high-spectral emission devices like end-user devices and distributed generation systems. This study proposed a new sliding-window wavelet-modified estimation of signal parameters by rotational invariance technique (ESPRIT method, particularly suitable for the spectral analysis of waveforms that have very wide spectra. The method is very accurate and requires reduced computational effort. It can be applied successfully to detect spectral components in the range of 0–150 kHz introduced both by distributed power plants, such as wind and photovoltaic generation systems, and by end-user equipment connected to grids through static converters, such as fluorescent lamps.
RCV-150 remotely operated vehicle and its operation in the hostile undersea environment
International Nuclear Information System (INIS)
Billet, A.B.
1984-01-01
The past decade has shown a dramatic increase in the use of unmanned tethered vehicles in worldwide marine fields. These are used for inspection, debris removal and object retrieval. The RCV-150/sup chemical bond/ system is an example of these advanced technology vehicles. With the requirements of high maneuverability and unusual inspection a responsive, high performance, compact hydraulic system was developed. The hydraulic system is powered by an electric motor-driven pump which provides hydraulic power to the four thruster motors and to the five-function manipulator work arm
Effective atomic number, electron density and kerma of gamma ...
Indian Academy of Sciences (India)
rare element optical glass with oxides of tungsten, tantalum and thorium. ... Similarly, gadolinium and lutetium exhibit only +3 oxidation state because .... (σa) and effective molecular cross-section (σm) are related by the following equation: σa =.
Calculating the energy spectrum of neutrons from tritium target of the NG-150 type generator
International Nuclear Information System (INIS)
Bortash, A.I.; Kuznetsov, V.S.
1987-01-01
Calculation procedure of neutron spectra yielding from the NG-150 generator target chamber with regard to deutron moderation is suggested. Using the suggested procedure, neutron spectra for different escape angles formed in the tritium target are calculated. The spectrum of neutrons scattered in cooling water is calculated. The mean energy of neutrons escaping at the angle of 0 deg equalling 14.5 MeV is obtained
Design, fabrication, test, and evaluation of a prototype 150-foot long composite wind turbine blade
Gewehr, H. W.
1979-01-01
The design, fabrication, testing, and evaluation of a prototype 150 foot long composite wind turbine blade is described. The design approach and material selection, compatible with low cost fabrication methods and objectives, are highlighted. The operating characteristics of the blade during rotating and nonrotating conditions are presented. The tensile, compression, and shear properties of the blade are reported. The blade fabrication, tooling, and quality assurance are discussed.
150 years of Sigmund Freud: What would Freud have said about the obesity epidemic?
Bornstein, S R; Wong, M-L; Licinio, J
2006-12-01
The 150th birthday of Sigmund Freud has triggered widespread interest and media coverage on his unique contribution and impact on society. Recent evidence from neuroscience and advanced imaging technology has provided support for some of his major concepts including the unconscious and the key role of early life events. In this perspective, we attempt to write on his behalf an updated version of a Freudian way of thinking focused on the current high rates of obesity and depression.
Direct Imaging of a Toroidal Magnetic Field in the Inner Jet of NRAO 150
Directory of Open Access Journals (Sweden)
Sol N. Molina
2016-11-01
Full Text Available Most formation models and numerical simulations cause a helical magnetic field to form, accelerate and collimate jets in active galactic nuclei (AGN. For this reason, observational direct evidence for the existence of these helical magnetic fields is of special relevance. In this work, we present ultra- high-resolution observations of the innermost regions of the jet in the quasar NRAO150. We study the polarization structure and report evidence of a helical magnetic field.
Directory of Open Access Journals (Sweden)
S. Aggrey-Smith
2016-03-01
Full Text Available This paper compares the attenuation coefficients of 20 tropical hard wood species based on their linear and mass attenuation and half value layer (HVL properties for X-rays of energy 50–150 keV using a narrow collimated beam from a Cs-137 source. The narrow collimated beam method made corrections from multiple and small-angle scatterings of photons unnecessary. The attenuation depended on the chemical composition and densities of the wood species. The linear attenuation coefficients of wood species at 50–150 keV were highest for Pterygota macrocarpa (4.53 m−1 and lowest for Antiaris africana (1.24 m−1; the mass attenuation coefficient was highest for Triplochiton scleroxylon (17.62 m2/kg and lowest for Nesogordonia papaverifera (2.27 m2/kg.The HVL was highest for Antiaris africana (0.27 m and lowest for Pterygota macrocarpa (0.149 m. Pterygota macrocarpa of about 0.36 m thickness could serve as a more affordable radiation shielding material against secondary scatter and leakage radiations in place of lead, copper or concrete for low X-ray radiations up to 150 keV.
Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression
Czech Academy of Sciences Publication Activity Database
Aherne, S.T.; Madden, S.F.; Hughes, D. J.; Pardini, B.; Naccarati, A.; Levý, M.; Vodička, Pavel; Neary, P.; Dowling, P.; Clynes, M.
2015-01-01
Roč. 15, apr 30 (2015), s. 2-13 ISSN 1471-2407 R&D Projects: GA ČR GAP304/10/1286 Institutional support: RVO:68378041 Keywords : colorectal cancer * circulating miRNAs * miR-34a * miR-150 * miR-923 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.265, year: 2015
Single event upsets calculated from new ENDF/B-VI proton and neutron data up to 150 MeV
International Nuclear Information System (INIS)
Chadwick, M.B.
1999-01-01
Single-event upsets (SEU) in microelectronics are calculated from newly-developed silicon nuclear reaction recoil data that extend up to 150 MeV, for incident protons and neutrons. Calculated SEU cross sections are compared with measured data
Advanced ACTPol Multichroic Polarimeter Array Fabrication Process for 150 mm Wafers
Duff, S. M.; Austermann, J.; Beall, J. A.; Becker, D.; Datta, R.; Gallardo, P. A.; Henderson, S. W.; Hilton, G. C.; Ho, S. P.; Hubmayr, J.; Koopman, B. J.; Li, D.; McMahon, J.; Nati, F.; Niemack, M. D.; Pappas, C. G.; Salatino, M.; Schmitt, B. L.; Simon, S. M.; Staggs, S. T.; Stevens, J. R.; Van Lanen, J.; Vavagiakis, E. M.; Ward, J. T.; Wollack, E. J.
2016-08-01
Advanced ACTPol (AdvACT) is a third-generation cosmic microwave background receiver to be deployed in 2016 on the Atacama Cosmology Telescope (ACT). Spanning five frequency bands from 25 to 280 GHz and having just over 5600 transition-edge sensor (TES) bolometers, this receiver will exhibit increased sensitivity and mapping speed compared to previously fielded ACT instruments. This paper presents the fabrication processes developed by NIST to scale to large arrays of feedhorn-coupled multichroic AlMn-based TES polarimeters on 150-mm diameter wafers. In addition to describing the streamlined fabrication process which enables high yields of densely packed detectors across larger wafers, we report the details of process improvements for sensor (AlMn) and insulator (SiN_x) materials and microwave structures, and the resulting performance improvements.
Anomalous increase of solar anisotropy above 150GV in 1981-1983
International Nuclear Information System (INIS)
Ueno, H.; Fujii, Z.; Mori, S.; Morishita, I.; Nagashima, K.
1985-01-01
An analysis was carried out of the observed data with Nagoya (surface). Misato (34mwe) and Sakashita (80mwe) multi-directional muon telescopes for the solar activity maximum period of 1978-1983. These data respond to primaries extending over the median rigidity range 60GV to 600GV. The amplitude observed at the Sakashita station in 1981-1983 increased, especially in 1982; the amplitude is twice as large as that in 1978-1980, when those at Nagoya and Misato stations are nearly the same as those in 1978-1980. Uni-directional anisotropy is derived by the best fit method by assuming a flat rigidity spectrum with the upper coutoff rigidity Pu. The value of Pu obtained is 270GV in 1981-1983 and 150GV in 1978-1980
Giacobbi, Nicholas S; Sluis-Cremer, Nicolas
2017-07-01
Rilpivirine (RPV), dapivirine (DPV), and MIV-150 are in development as microbicides. It is not known whether they will block infection of circulating nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant human immunodeficiency virus type 1 (HIV-1) variants. Here, we demonstrate that the activity of DPV and MIV-150 is compromised by many resistant viruses containing single or double substitutions. High DPV genital tract concentrations from DPV ring use may block replication of resistant viruses. However, MIV-150 genital tract concentrations may be insufficient to inhibit many resistant viruses, including those harboring K103N or Y181C. Copyright © 2017 American Society for Microbiology.
New channeling effects in the radiative emission of 150 GeV electrons in a thin germanium crystal
International Nuclear Information System (INIS)
Belkacem, A.; Chevallier, M.; Gaillard, M.J.; Genre, R.; Kirsch, R.; Poizat, J.C.; Remillieux, J.; Bologna, G.; Peigneux, J.P.; Sillou, D.; Spighel, M.; Cue, N.; Kimball, J.C.; Marsh, B.; Sun, C.R.
1986-01-01
The orientation dependence of the radiative emission of 150 GeV electrons and positrons incident at small angles with respect to the axial direction of a thin (0.185 mm) Ge crystal has been observed. The processes are well understood, except for channeled electrons, which radiate unexpected high energy photons. (orig.)
2011-07-06
... Exemptions for Advisers to Venture Capital Funds, Private Fund Advisers With Less Than $150 Million in Assets... Investment Advisers Registration Act of 2010--the new rules define ``venture capital fund'' and provide an... Venture Capital Strategy 8. Is a Private Fund 9. Application to Non-U.S. Advisers 10. Grandfathering...
International Nuclear Information System (INIS)
Rana, S.B.; Pecho, J.
1975-01-01
The in-core flux mapping system in the KS-150 reactor using mapping fuel elements with self-powered detectors is described. Experimental data evaluation using the Fourier analysis and determination of important operation parameters from the detectors and temperature field distribution using thermocouples for measuring coolant outlet temperatures and fuel temperatures are given. The DPZ-1 detectors used, mapping fuel elements and the method of signal registration are described. The results of operation of mapping fuel elements during the 2nd period of the KS-150 reactor commissioning are given. (author)
Efficient biostorage below -150 °C, without sacrificial cryogen
Spoor, Philip S.
2017-12-01
Biostorage is a multi-billion dollar business worldwide and growing rapidly; yet the commercially available options force the user to choose either optimal storage temperature (below -137 °C, the “glass transition temperature” of water) or convenience (no cryogen refill). Passive liquid-nitrogen freezers (storage Dewars with liquid nitrogen pooled at the bottom) provide very cold storage (-190 °C) but the LN2 must be replenished as it boils off. The alternative, so-called “ultra-low” vapor-compression freezers, have no cryogens to replenish and are convenient to use, but only reach storage temperatures above -90 °C. In addition, these tend to be inefficient and costly. Chart Industries is introducing a novel combination of a storage Dewar with a cryocooler (the “Fusion” freezer), that can maintain storage temperatures below -150 °C without the need to replenish any cryogen, while drawing less electricity than any ultra-low on the market. This new product also fits into a relatively narrow “demand window” where on-site cryocooling is not merely more convenient, but also more costeffective than liquid nitrogen delivery.
Test facility for the development of 150-keV, multi-megawatt neutral beam systems
International Nuclear Information System (INIS)
Haughian, W.; Baker, W.R.; Biagi, L.A.; Hopkins, D.B.
1975-11-01
The next generation of CTR experiments, such as the Tokamak Fusion Test Reactor (TFTR), will require neutral-beam injection systems that produce multi-megawatt, 120-keV deuterium-beam pulses of 0.5-second duration. Since present injection systems are operating in the 10- to 40-keV range, an intensive development effort is in progress to meet a 150-keV requirement. The vacuum system and power supplies that make up a test facility to be used in the development of these injectors are described
Energy Technology Data Exchange (ETDEWEB)
Roy, CH
1996-02-07
In this work, we present a study concerning some collective phenomena in highly central Au (150 - 400 A MeV) + Au collisions, measured with the FOPI detector. The selection of the central reactions is performed by applying a criterion whose definition is based on the concept that low impact parameter reactions imply the non-existence of projectile and target remnants. The analysis of the center-of-mass polar angular distributions indicates that fragments (Z {<=} 3) are emitted preferentially in the direction transverse to the be beam axis. The shape of these distributions depends strongly on the degree of stopping of the nuclear matter. In the Quantum Molecular Dynamics (QMD) calculations, this phenomenon is mainly parameterized with the nucleon-nucleon cross-section ({sigma}{sub nn}). The comparison of the experimental polar angle distributions with those predicted by QMD suggests a value of 30 mb for {sigma}{sub nn} to reproduce the experimental trend observed at 150 A MeV incident energy. A simulation of a thermal source whose expansion is partially governed by a transverse flow indicates that the collective energy represents about 75 % of the total transverse energy ({approx} 65 % at 250 and 400 A MeV). (author). 102 refs.
Helical tomotherapy. Experiences of the first 150 patients in Heidelberg
Energy Technology Data Exchange (ETDEWEB)
Sterzing, F.; Schubert, K.; Sroka-Perez, G.; Kalz, J.; Debus, J.; Herfarth, K. [Dept. of Radiation Oncology, Univ. of Heidelberg (Germany)
2008-01-15
Background and purpose: helical tomotherapy was introduced into clinical routine at the Department of Radiation Oncology, University Hospital of Heidelberg, Germany, in July 2006. This report is intended to describe the experience with the first 150 patients treated with helical tomotherapy. Patient selection, time effort, handling of daily image guidance with megavoltage (MV) CT, and quality of radiation plans shall be assessed. Patients and methods: between July 2006 and May 2007, 150 patients were treated with helical tomotherapy in the University Hospital of Heidelberg. Mean age was 60 years with a minimum of 30 years and a maximum of 85 years. 79 of these patients received radiotherapy as a part of multimodal treatment pre- or postoperatively, 17 patients received treatment as a combined radiochemotherapy. 76% were treated with curative intent. Radiotherapy sites were central nervous system (n = 7), head and neck (n = 28), thoracic (n = 37), abdominal (n = 58) and skeletal system (n = 20). Most common tumor entities were prostate cancer (n = 28), breast cancer (n = 17), gastrointestinal tumors (n = 19), pharyngeal carcinoma (n = 14), lymphoma (n = 13), metastatic disease (bone n = 14, liver n = 6, lung n = 4, lymph node n = 2), sarcoma (n = 8), malignant pleural mesothelioma (n = 5), ovarian cancer treated with whole abdominal irradiation (n = 4), lung cancer (n = 3), skin malignancies (n = 3), chordoma (n = 2), meningioma (n = 2), one ependymoma and one medulloblastoma treated with craniospinal axis irradiation (n = 2), and others (n = 4). Nine patients were treated with single-fraction radiosurgery, nine with image-guided spinal reirradiation, and twelve patients were treated at multiple targets simultaneously. A pretreatment MV-CT scan was performed in 98.2% of the 3,026 fractions applied. After matching with the kilovoltage planning CT, corrections for translations and rotation around longitudinal axis (roll) were done. Results: mean time on table was 24
Mikamo, Hiroshige; Matsumizu, Miyako; Nakazuru, Yoshiomi; Okayama, Akifumi; Nagashima, Masahito
2015-07-01
Vulvovaginal candidiasis is the second most common cause of vaginal infections following bacterial vaginosis. For the treatment of vulvovaginal candidiasis, antifungal agents are used either as topical (vaginal tablets and cream) or oral formulations. A single oral 150 mg dose of fluconazole has been recommended as the standard therapy for uncomplicated, acute vulvovaginal candidiasis in global guidelines; however, in Japan oral fluconazole therapy has not been approved. We conducted a phase 3 study to evaluate the efficacy and safety of a single oral 150 mg dose of fluconazole in Japanese subjects with vulvovaginal candidiasis for regulatory submission. A total of 157 subjects received a single oral 150 mg dose of fluconazole. Candida species (104 strains) were identified by fungal culture from 102 subjects at baseline, including Candida albicans (100 strains). The efficacy rate for the therapeutic outcome (assessed based on a comprehensive evaluation of the clinical and mycological efficacy in each subject) was 74.7% (74/99) on Day 28 in the modified Intent-To-Treat (m-ITT) population. Concerning the clinical and mycological efficacy on Day 28 in the m-ITT population, the cure, cure or improvement, and eradication rates were 81.6%, 95.9%, and 85.9%, respectively. The most common treatment-related adverse events were diarrhea and nausea (1.9% for each). No clinically significant safety issues were reported. A single oral 150 mg dose of fluconazole demonstrated excellent therapeutic efficacy and was well tolerated in Japanese subjects with vulvovaginal candidiasis. NCT01806623. Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Body size, skills, and income: evidence from 150,000 teenage siblings.
Lundborg, Petter; Nystedt, Paul; Rooth, Dan-Olof
2014-10-01
We provide new evidence on the long-run labor market penalty of teenage overweight and obesity using unique and large-scale data on 150,000 male siblings from the Swedish military enlistment. Our empirical analysis provides four important results. First, we provide the first evidence of a large adult male labor market penalty for being overweight or obese as a teenager. Second, we replicate this result using data from the United States and the United Kingdom. Third, we note a strikingly strong within-family relationship between body size and cognitive skills/noncognitive skills. Fourth, a large part of the estimated body-size penalty reflects lower skill acquisition among overweight and obese teenagers. Taken together, these results reinforce the importance of policy combating early-life obesity in order to reduce healthcare expenditures as well as poverty and inequalities later in life.
Generating an AC amplitude magnetic flux density value up to 150 μT at a frequency up to 100 kHz
Ulvr, Michal; Polonský, Jakub
2017-05-01
AC magnetic field analyzers with a triaxial coil probe are widely used by health and safety professionals, in manufacturing, and in service industries. For traceable calibration of these analyzers, it is important to be able to generate a stable, homogeneous reference AC magnetic flux density (MFD). In this paper, the generating of AC amplitude MFD value of 150 μT by single-layer Helmholtz type solenoid, described in previous work, was expanded up to a frequency of 100 kHz using the effect of serial resonance. A programmable capacitor array has been developed with a range of adjustable values from 50 pF to 51225 pF. In addition, the multi-layer search coil with a nominal area turns value of 1.3m2, used for adjusting AC MFD in the solenoid, has been modified by a transimpedance amplifier for use in a wider frequency range than up to 3 kHz. The possibility of using the programmable capacitor array up to 150 kHz has also been tested. An AC amplitude MFD value of 150 μT can be generated with expanded uncertainty better than 0.6% up to 100 kHz.
Reaction Dynamics of CH{sub 3} + HBr → CH{sub 4} + Br at 150-1000 K
Energy Technology Data Exchange (ETDEWEB)
Ree, Jongbaik [Chonnam National Univ., Gwangju (Korea, Republic of); Kim, Yoo Hang [Inha Univ., Incheon (Korea, Republic of); Shin, Hyung Kyu [Univ. of Nevado, Nevado (United States)
2013-08-15
The kinetics of the radical-polar molecule reaction CH{sub 3} + HBr → CH{sub 4} + Br has been studied at temperatures between 150 and 1000 K using classical dynamics procedures. Potential energy surfaces constructed using analytical forms of inter- and intramolecular interaction energies show a shallow well and barrier in the entrance channel, which affect the collision dynamics at low temperatures. Different collision models are used to distinguish the reaction occurring at low- and high-temperature regions. The reaction proceeds rapidly via a complex-mode mechanism below room temperature showing strong negative temperature dependence, where the effects of molecular attraction, H-atom tunneling and recrossing of collision complexes are found to be important. The temperature dependence of the rate constant between 400 and 1000 K is positive, the values increasing in accordance with the increase of the mean speed of collision. The rate constant varies from 7.6 Χ 10{sup -12} at 150 K to 3.7 Χ 10{sup -12} at 1000 K via a minimum value of 2.5 Χ 10{sup -12} cm{sup 3} molecule{sup -1} s{sup -1} at 400 K.
Molecular findings and clinical data in a cohort of 150 patients with anophthalmia/microphthalmia.
Chassaing, N; Causse, A; Vigouroux, A; Delahaye, A; Alessandri, J-L; Boespflug-Tanguy, O; Boute-Benejean, O; Dollfus, H; Duban-Bedu, B; Gilbert-Dussardier, B; Giuliano, F; Gonzales, M; Holder-Espinasse, M; Isidor, B; Jacquemont, M-L; Lacombe, D; Martin-Coignard, D; Mathieu-Dramard, M; Odent, S; Picone, O; Pinson, L; Quelin, C; Sigaudy, S; Toutain, A; Thauvin-Robinet, C; Kaplan, Josseline; Calvas, Patrick
2014-10-01
Anophthalmia and microphthalmia (AM) are the most severe malformations of the eye, corresponding respectively to reduced size or absent ocular globe. Wide genetic heterogeneity has been reported and different genes have been demonstrated to be causative of syndromic and non-syndromic forms of AM. We screened seven AM genes [GDF6 (growth differentiation factor 6), FOXE3 (forkhead box E3), OTX2 (orthodenticle protein homolog 2), PAX6 (paired box 6), RAX (retina and anterior neural fold homeobox), SOX2 (SRY sex determining region Y-box 2), and VSX2 (visual system homeobox 2 gene)] in a cohort of 150 patients with isolated or syndromic AM. The causative genetic defect was identified in 21% of the patients (32/150). Point mutations were identified by direct sequencing of these genes in 25 patients (13 in SOX2, 4 in RAX, 3 in OTX2, 2 in FOXE3, 1 in VSX2, 1 in PAX6, and 1 in GDF6). In addition eight gene deletions (five SOX2, two OTX2 and one RAX) were identified using a semi-quantitative multiplex polymerase chain reaction (PCR) [quantitative multiplex PCR amplification of short fluorescent fragments (QMPSF)]. The causative genetic defect was identified in 21% of the patients. This result contributes to our knowledge of the molecular basis of AM, and will facilitate accurate genetic counselling. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Radiation hardness evaluation of the commercial 150 nm CMOS process using 60Co source
International Nuclear Information System (INIS)
Carna, M; Havranek, M; Hejtmanek, M; Janoska, Z; Marcisovsky, M; Neue, G; Tomasek, L; Vrba, V
2014-01-01
We present a study of radiation effects on MOSFET transistors irradiated with a 60 Co source to a total absorbed dose of 1.5 Mrad. The transistor test structures were manufactured using a commercial 150 nm CMOS process and are composed of transistors of different types (NMOS and PMOS), dimensions and insulation from the bulk material by means of deep n-wells. We have observed a degradation of electrical characteristics of both PMOS and NMOS transistors, namely a large increase of the leakage current of the NMOS transistors after irradiation
Simple model for deriving sdg interacting boson model Hamiltonians: 150Nd example
Devi, Y. D.; Kota, V. K. B.
1993-07-01
A simple and yet useful model for deriving sdg interacting boson model (IBM) Hamiltonians is to assume that single-boson energies derive from identical particle (pp and nn) interactions and proton, neutron single-particle energies, and that the two-body matrix elements for bosons derive from pn interaction, with an IBM-2 to IBM-1 projection of the resulting p-n sdg IBM Hamiltonian. The applicability of this model in generating sdg IBM Hamiltonians is demonstrated, using a single-j-shell Otsuka-Arima-Iachello mapping of the quadrupole and hexadecupole operators in proton and neutron spaces separately and constructing a quadrupole-quadrupole plus hexadecupole-hexadecupole Hamiltonian in the analysis of the spectra, B(E2)'s, and E4 strength distribution in the example of 150Nd.
Simple model for deriving sdg interacting boson model Hamiltonians: 150Nd example
International Nuclear Information System (INIS)
Devi, Y.D.; Kota, V.K.B.
1993-01-01
A simple and yet useful model for deriving sdg interacting boson model (IBM) Hamiltonians is to assume that single-boson energies derive from identical particle (pp and nn) interactions and proton, neutron single-particle energies, and that the two-body matrix elements for bosons derive from pn interaction, with an IBM-2 to IBM-1 projection of the resulting p-n sdg IBM Hamiltonian. The applicability of this model in generating sdg IBM Hamiltonians is demonstrated, using a single-j-shell Otsuka-Arima-Iachello mapping of the quadrupole and hexadecupole operators in proton and neutron spaces separately and constructing a quadrupole-quadrupole plus hexadecupole-hexadecupole Hamiltonian in the analysis of the spectra, B(E2)'s, and E4 strength distribution in the example of 150 Nd
Hong, Gyu-Sang; Lee, Byeongjun; Wee, Jungwon; Chun, Hyeyeon; Kim, Hyungsup; Jung, Jooyoung; Cha, Joo Young; Riew, Tae-Ryong; Kim, Gyu Hyun; Kim, In-Beom; Oh, Uhtaek
2016-07-06
Touch sensation or proprioception requires the transduction of mechanical stimuli into electrical signals by mechanoreceptors in the periphery. These mechanoreceptors are equipped with various transducer channels. Although Piezo1 and 2 are mechanically activated (MA) channels with rapid inactivation, MA molecules with other inactivation kinetics have not been identified. Here we report that heterologously expressed Tentonin3 (TTN3)/TMEM150C is activated by mechanical stimuli with distinctly slow inactivation kinetics. Genetic ablation of Ttn3/Tmem150c markedly reduced slowly adapting neurons in dorsal-root ganglion neurons. The MA TTN3 currents were inhibited by known blockers of mechanosensitive ion channels. Moreover, TTN3 was localized in muscle spindle afferents. Ttn3-deficient mice exhibited the loss of coordinated movements and abnormal gait. Thus, TTN3 appears to be a component of a mechanosensitive channel with a slow inactivation rate and contributes to motor coordination. Identification of this gene advances our understanding of the various types of mechanosensations, including proprioception. Copyright © 2016 Elsevier Inc. All rights reserved.
DEFF Research Database (Denmark)
Poon, Anna Fong-Yee; Schmid, Benjamin; Pires, Carlota
2016-01-01
a familial AD patient carrying a L150P point mutation in PSEN1. Here we used CRISPR/Cas9 gene editing to correct for the single base pair mutation. This gene-corrected line, L150P-GC-hiPSC, serves as an isogenic control to the mutant line for future investigation of mechanisms and cellular phenotypes altered...
International Nuclear Information System (INIS)
Radon, M.R.; Kaduthodil, M.J.; Jagdish, J.; Matthews, S.; Hill, C.; Bull, M.J.; Morcos, S.K.
2011-01-01
Aim: To assess the feasibility of producing diagnostic multidetector computed tomography (MDCT) pulmonary angiography with low iodine concentration contrast media (150 mg iodine/ml) in patients with suspected acute pulmonary embolism. Materials and methods: Ninety-five randomized patients underwent MDCT (64 row) pulmonary angiography with 100 ml iopromide either at low concentration (LC) of 150 mg iodine/ml (n = 45) or high concentration (HC) of 300 mg iodine/ml (n = 50), delivered at the rate of 5 ml/s via a power injector. Two experienced radiologists, blinded to the concentration used, subjectively assessed the diagnostic quality and confidence using a four-point scale [1 = poor (not diagnostic), 2 = satisfactory, 3 = good, 4 = excellent]. Attenuation values (in HU) were measured in the main proximal branches of the pulmonary arteries. Results: The median diagnostic quality score for both observers was 3.5 (interquartile range 3-4) in the HC group and 2.5 (interquartile range 1.5-3) in the LC group (p < 0.01). The median diagnostic confidence score for both observers was 4 (interquartile range 3-4) in the HC group and 3 (interquartile range 1.5-4) in the LC group (p < 0.01). Both observers rated examinations as diagnostic in 69% of cases in the LC group, compared with 96% of cases in the HC group. Good interobserver agreement was found in both groups (K value 0.72 in the LC group and 0.73 in the HC). Obesity, poor scan timing, and dilution by venous return of non-opacified blood were the main reasons for a reduction in diagnostic quality of examinations in the LC group. Conclusion: Despite a 50% reduction of contrast medium dose in comparison to the standard technique, 150 mg iodine/ml can produce diagnostic MDCT pulmonary angiogram studies in the absence of obesity or high cardiac output and hyper-dynamic pulmonary circulation. Reducing the dose of contrast media would minimize the risk of contrast nephropathy in patients at risk of this complication
Ostroveanu, Anghelus; Van der Zee, Eddy A.; Dolga, Amalia M.; Luiten, Paul G. M.; Eisel, Ulrich L. M.; Nijholt, Ingrid M.
2007-01-01
A-kinase anchoring proteins (AKAPs) form large macromolecular signaling complexes that specifically target cAMP-dependent protein kinase (PKA) to unique subcellular compartments and thus, provide high specificity to PKA signaling. For example, the AKAP79/150 family tethers PKA, PKC and PP2B to
Addendum 2 to CSER 79-002: Extension of the 150 gram fissile limit used in room 187 of PFP
International Nuclear Information System (INIS)
Friar, D.E.
1994-01-01
The PFP operating organization requests that the limit set permitting 150 grams fissile be extended to the Hoods 4 and 5 of Room 187. The request for the limit change is explained in the attached request for analysis
Prominent transverse flow of clusters in stopped Au(150AMeV)+Au reactions
International Nuclear Information System (INIS)
Coffin, J.P.; Kuhn, C.; Roy, C.; Cerruti, C.; Crochet, P.; Fintz, P.; Guillaume, G.; Houari, A.; Jundt, F.; Rami, F.; Tizniti, L.; Wagner, P.; Konopka, J.; Stoecker, H.
1995-01-01
Stopped Au(150AMeV)+Au collisions have been measured with the FOPI-Detector at GSI by imposing an upper limit on the ratio of the global longitudinal momentum to the collected charge within an event. The ejectiles, in particular those with Z>3, have a rapidity close to mid-rapidity and exhibit angular distributions in the centre-of-mass strongly peaking around 90 thus suggesting an enhancement of the flow in the transverse direction. Fits to the data and comparisons with QMD calculations indicate an averaged collective velocity in the transverse direction equal to 0.12c. Significance of the determined velocity and temperature values is discussed. ((orig.))
Underground trials on a newly developed EDW 150-2 L unit
Energy Technology Data Exchange (ETDEWEB)
Wille, G.; Klimek, K.H.
1982-01-01
Coal-getting from medium thick coalbeds (> 1.7 m) requires high-performance shearer-loaders. Machine length and adjustability have to be such as to permit smooth cutting through geological faults. Furthermore they should be suitable to cut out niches for the AFC drives so that gateroads can be driven along with the face line. The newly developed EDW 150-2 L shearer-loader meets these expectations after various mechanical and electrical improvements. The unit proved its usefulness from the beginning and in the most difficult geological conditions where other shearer-loaders normally available for the range of coalbed thickness would mostly have failed. The multiple requirements and disturbances have led to a number of separate improvements and disturbances have led to a number of separate improvements which together contribute to a basic improvement of the machine concept as far as applications, operational flexibility and safety are concerned.
Photon multiplicity in the hard radiation of 150 GeV electrons in an aligned germanium crystal
International Nuclear Information System (INIS)
Belkacem, A.; Chevallier, M.; Gaillard, M.J.; Genre, R.; Kirsch, R.; Poizat, J.C.; Remillieux, J.; Bologna, G.; Peigneux, J.P.; Sillou, D.; Spighel, M.; Cue, N.; Kimball, J.C.; Marsh, B.B.; Sun, C.R.
1988-01-01
Mean values m of photon multiplicity in the radiation of 150 GeV electrons directed at and near the axis of a 0.185 mm thick Ge crystal cooled to 100 K have been deduced from the measurements of pair conversion probabilities. Depending on the distribution of multiplicity assumed, values of m ranging from 3.8 to 4.3 are obtained for the previously reported anomalous radiation peak. (orig.)
Rotational-mode component of the density of levels of nuclei with A approx-lt 150
International Nuclear Information System (INIS)
Rastopchin, E.M.; Svirin, M.I.; Smirenkin, G.N.
1992-01-01
Some difficulties which arise in the use of the generalized superfluid model to describe the density of levels in the region A approx-lt 150, as the result of an imperfect understanding of collective nuclear excitations, are discussed. One possible way to overcome these difficulties is examined. The idea is to depart from the conventional classification of collective nuclear properties and make use of small static deformations predicted theoretically and a corresponding rotational-mode component of the density of levels of these nuclei
76 FR 31230 - Safety Zone; M.I.T.'s 150th Birthday Celebration Fireworks, Charles River, Boston, MA
2011-05-31
...-AA00 Safety Zone; M.I.T.'s 150th Birthday Celebration Fireworks, Charles River, Boston, MA AGENCY... regulated area on the Charles River around the fireworks launch barge during the fireworks display... portions of the Charles River during a fireworks display. This rule will not have a significant economic...
150-MW S-Band klystron program at the Stanford Linear Accelerator Center
Energy Technology Data Exchange (ETDEWEB)
Sprehn, D.; Caryotakis, G.; Phillips, R.M. [Stanford Linear Accelerator Center, Stanford Univ., Stanford, CA (United States)
1997-04-01
Two S-Band klystrons operating at 150 MW have been designed, fabricated and tested at the Stanford Linear Accelerator Center (SLAC) during the past two years for use in an experimental accelerator at Deutsches Elektronen Synchrotron (DESY) in Hamburg, Germany. Both klystrons operate at the design power, 60 Hz repetition rate, 3 {mu}s pulsewidth, with an efficiency > 40%, and agreement between the experimental results and simulations is excellent. The 535 kV, 700 A electron gun was tested by constructing a solenoidal focused beam-stick which identified a source of oscillation, subsequently engineered out of the klystron guns. Design of the beam-stick and the two klystrons is discussed, along with observation and suppression of spurious oscillations. Differences in design and the resulting performance of the klystrons is emphasized. (author)
Anomalously weak Labrador Sea convection and Atlantic overturning during the past 150 years.
Thornalley, David J R; Oppo, Delia W; Ortega, Pablo; Robson, Jon I; Brierley, Chris M; Davis, Renee; Hall, Ian R; Moffa-Sanchez, Paola; Rose, Neil L; Spooner, Peter T; Yashayaev, Igor; Keigwin, Lloyd D
2018-04-01
The Atlantic meridional overturning circulation (AMOC) is a system of ocean currents that has an essential role in Earth's climate, redistributing heat and influencing the carbon cycle 1, 2 . The AMOC has been shown to be weakening in recent years 1 ; this decline may reflect decadal-scale variability in convection in the Labrador Sea, but short observational datasets preclude a longer-term perspective on the modern state and variability of Labrador Sea convection and the AMOC 1, 3-5 . Here we provide several lines of palaeo-oceanographic evidence that Labrador Sea deep convection and the AMOC have been anomalously weak over the past 150 years or so (since the end of the Little Ice Age, LIA, approximately AD 1850) compared with the preceding 1,500 years. Our palaeoclimate reconstructions indicate that the transition occurred either as a predominantly abrupt shift towards the end of the LIA, or as a more gradual, continued decline over the past 150 years; this ambiguity probably arises from non-AMOC influences on the various proxies or from the different sensitivities of these proxies to individual components of the AMOC. We suggest that enhanced freshwater fluxes from the Arctic and Nordic seas towards the end of the LIA-sourced from melting glaciers and thickened sea ice that developed earlier in the LIA-weakened Labrador Sea convection and the AMOC. The lack of a subsequent recovery may have resulted from hysteresis or from twentieth-century melting of the Greenland Ice Sheet 6 . Our results suggest that recent decadal variability in Labrador Sea convection and the AMOC has occurred during an atypical, weak background state. Future work should aim to constrain the roles of internal climate variability and early anthropogenic forcing in the AMOC weakening described here.
International Nuclear Information System (INIS)
Zietara, R.
1980-01-01
Experimental studies were carried out on 120 white, male Wistar rats weighing 180-220 g, aged 3-4 months. Animals were divided in 4 groups. In the 1 group only a wound involving skin and muscles was produced. In the 2 group animals after injury received cysteamine in a single dose of 120 mg per kg of body weight. In the 3 group animals after injury were irradiated up to the dose of 150 R. In the 4 group injured animals received cysteamine in dose of 120 mg per kg of body weight and were subsequently irradiated up to the dose 150 R. It was observed that cysteamine given intraperitoneally in dose of 120 mg per kg of body weight 15-20 minutes prior to irradiation provides a normal course of damage and effort periods of healing and proper granulation of the cutanomuscular wound. (author)
Inter-comparison of High Energy Files (neutron-induced, from 20 to 150 MeV)
Energy Technology Data Exchange (ETDEWEB)
Lee, Young-Ouk; Fukahori, Tokio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment
1998-11-01
Recent new applications using accelerator-driven system require well-tested nuclear data when modeling the interaction of neutrons above 20 MeV. This work is aimed to review evaluation methods applied in currently available neutron high energy files above 20 to 150 MeV, to inter-compare their evaluated cross sections on some important isotopes, and to analyze resulting discrepancies. Through out these, integrities and consistencies of the high energy files are checked, applicability of physics models and evaluation methodologies are assessed, and some directions are derived to improve and expand current JENDL High Energy File. (author)
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
DEFF Research Database (Denmark)
Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent
2017-01-01
or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...
Optimize of Deuteron Current of 150 keV, 1 mA Neutron Generator
International Nuclear Information System (INIS)
Sri Sulamdari; Djasiman
2003-01-01
It has been characterized a 150 keV/1 mA Neutron Generator. It has been used some local components, except accelerator tube and vacuum system. To produce neutron, it has been used a deuterium gas bombarded into tritium target through reaction 3 H(d,n) 4 He. For preliminary experiment, we used the air as an ion source. The beam current of deuteron as a function of process parameters are presented in this paper. It's found that the optimum beam current of deuteron was 1000 μA, and this conditions was achieved at accelerations voltage 30 kV, extraction voltage 5 kV, guide voltage -11 kV and vacuum 10 -6 mbar. (author)
Hooper, Carole
2011-01-01
This article provides an historical account of how fee-charging Victorian schools have marketed themselves over the past 150 years (via the use of advertisements, brochures, and prospectuses) in order to promote those aspects of schooling believed to be of most importance to potential customers (parents). While some of the features--most notably…
Validation of GEANT3 simulation studies with a dual-head PMT ClearPET TM prototype
Ziemons, K; Streun, M; Pietrzyk, U
2004-01-01
The ClearPET TM project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2/sup nd/ generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET TM camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0% the simulated intrinsic resolution is about (...
Pan, Liangjie; Jiang, Benxue; Fan, Jintai; Yang, Qiuhong; Zhou, Chunlin; Zhang, Pande; Mao, Xiaojian; Zhang, Long
2015-01-01
The synthesis of pure and well dispersed lutetium aluminum garnet (LuAG) powder is crucial and important for the preparation of LuAG transparent ceramics. In this paper, high purity and well dispersed LuAG powders have been synthesized via co-precipitation method with lutetium nitrate and aluminum nitrate as raw materials. Ammonium hydrogen carbonate (AHC) was used as the precipitant. The influence of aging time, pH value, and dripping speed on the prepared LuAG powders were investigated. It showed that long aging duration (>15 h) with high terminal pH value (>7.80) resulted in segregation of rhombus Lu precipitate and Al precipitate. By decreasing the initial pH value or accelerating the dripping speed, rhombus Lu precipitate was eliminated and pure LuAG nano powders were synthesized. High quality LuAG transparent ceramics with transmission >75% at 1064 nm were fabricated using these well dispersed nano LuAG powders. PMID:28793510
Directory of Open Access Journals (Sweden)
Liangjie Pan
2015-08-01
Full Text Available The synthesis of pure and well dispersed lutetium aluminum garnet (LuAG powder is crucial and important for the preparation of LuAG transparent ceramics. In this paper, high purity and well dispersed LuAG powders have been synthesized via co-precipitation method with lutetium nitrate and aluminum nitrate as raw materials. Ammonium hydrogen carbonate (AHC was used as the precipitant. The influence of aging time, pH value, and dripping speed on the prepared LuAG powders were investigated. It showed that long aging duration (>15 h with high terminal pH value (>7.80 resulted in segregation of rhombus Lu precipitate and Al precipitate. By decreasing the initial pH value or accelerating the dripping speed, rhombus Lu precipitate was eliminated and pure LuAG nano powders were synthesized. High quality LuAG transparent ceramics with transmission >75% at 1064 nm were fabricated using these well dispersed nano LuAG powders.
Response of Inorganic Scintillators to Neutrons of 3 and 15 MeV Energy
Lucchini, M; Pizzichemi, M; Chipaux, R; Jacquot, F; Mazue, H; Wolff, H; Lecoq, P; Auffray, E
2014-01-01
In the perspective of the development of future high energy physics experiments, homogeneous calorimeters based on inorganic scintillators can be considered for the detection of hadrons (e.g., calorimeter based on dual-readout technique). Although of high importance in the high energy physics framework as well as for homeland security applications, the response of these inorganic scintillators to neutrons has been only scarcely investigated. This paper presents results obtained using five common scintillating crystals (of size around 2x2x2 cm 3), namely lead tungstate (PbWO4), bismuth germanate (BGO), cerium fluoride (CeF3), Ce-doped lutetium-yttrium orthosilicate (LYSO:Ce) and lutetium aluminum garnet (LuAG:Ce) in a pulsed flux of almost mono-energetic (similar to 3 MeV and similar to 15 MeV) neutrons provided by the Van de Graff accelerator SAMES of CEA Valduc. Energy spectra have been recorded, calibrated and compared with Geant4 simulations computed with different physics models. The neutron detection eff...
Content analysis of 150 years of British periodicals.
Lansdall-Welfare, Thomas; Sudhahar, Saatviga; Thompson, James; Lewis, Justin; Cristianini, Nello
2017-01-24
Previous studies have shown that it is possible to detect macroscopic patterns of cultural change over periods of centuries by analyzing large textual time series, specifically digitized books. This method promises to empower scholars with a quantitative and data-driven tool to study culture and society, but its power has been limited by the use of data from books and simple analytics based essentially on word counts. This study addresses these problems by assembling a vast corpus of regional newspapers from the United Kingdom, incorporating very fine-grained geographical and temporal information that is not available for books. The corpus spans 150 years and is formed by millions of articles, representing 14% of all British regional outlets of the period. Simple content analysis of this corpus allowed us to detect specific events, like wars, epidemics, coronations, or conclaves, with high accuracy, whereas the use of more refined techniques from artificial intelligence enabled us to move beyond counting words by detecting references to named entities. These techniques allowed us to observe both a systematic underrepresentation and a steady increase of women in the news during the 20th century and the change of geographic focus for various concepts. We also estimate the dates when electricity overtook steam and trains overtook horses as a means of transportation, both around the year 1900, along with observing other cultural transitions. We believe that these data-driven approaches can complement the traditional method of close reading in detecting trends of continuity and change in historical corpora.
Sindagi, S. C.; Sandhu, B. S.
2015-04-01
With the increased load on highways, today there is a need to develop alternate ways to transport goods within the sovereignty. The use of ships to transport goods has always been the primary method of transporting goods across the seas but it can also be used to transport goods within the country. This way we can reduce the load on highways which at this point of time serve as the primary method of transportation. Worldwide very few ferries are in operation which transports 100-150 Trailers between two ports. Catching on this opportunity for design, construction and operation of vessels, a survey for possible routes in United States of America which will transport 150 Trailers has been conducted by various authorities and organizations. The challenge here is to determine the parameters of the vessel and design a fleet of vessels that could carry trailers along with their tractors within the least possible time and in with least possible freight between Jacksonville, FL and Bridgeport, CT of United States of America. The primary aim of the work presented here is to propose a design with fleet in such a way that each day 150 trailers could be loaded and unloaded at each of the two mentioned ports. An analysis of the route between the ports brought out various primary parameters like the distance, weather, different load lines to be encountered and also several size constraints that the vessel needs to adhere to, in order to ply smoothly on this route. The vessel is designed as per the Guidelines for ships operating in international waters. The economic analysis of the project was performed spanning over 20 years and the best freight was found out which would be most profitable for the company as well as be a good value for money for the customers.
Sub-arcsecond imaging of Arp 299-A at 150 MHz with LOFAR: Evidence for a starburst-driven outflow
Ramírez-Olivencia, N.; Varenius, E.; Pérez-Torres, M.; Alberdi, A.; Pérez, E.; Alonso-Herrero, A.; Deller, A.; Herrero-Illana, R.; Moldón, J.; Barcos-Muñoz, L.; Martí-Vidal, I.
2018-03-01
We report on the first sub-arcsecond (0.44 × 0.41 arcsec2) angular resolution image at 150 MHz of the A-nucleus in the luminous infrared galaxy Arp 299, from International Low Frequency Array (LOFAR) Telescope observations. The most remarkable finding is that of an intriguing two-sided, filamentary structure emanating from the A-nucleus, which we interpret as an outflow that extends up to at least 14 arcsec from the A-nucleus in the N-S direction ( ≈5 kpc deprojected size) and accounts for almost 40% of the extended emission of the entire galaxy system. We also discuss HST/NICMOS [FeII] 1.64 μm and H2 2.12 μm images of Arp 299-A, which show similar features to those unveiled by our 150 MHz LOFAR observations, providing strong morphological support for the outflow scenario. Finally, we discuss unpublished Na I D spectra that confirm the outflow nature of this structure. From energetic arguments, we rule out the low-luminosity active galactic nucleus in Arp 299-A as a driver for the outflow. On the contrary, the powerful, compact starburst in the central regions of Arp 299-A provides plenty of mechanical energy to sustain an outflow, and we conclude that the intense supernova (SN) activity in the nuclear region of Arp 299-A is driving the observed outflow. We estimate that the starburst wind can support a mass-outflow rate in the range (11-63 M⊙ yr-1) at speeds of up to 370-890 km s-1, and is relatively young, with an estimated kinematic age of 3-7 Myr. Those results open an avenue to the use of low-frequency (150 MHz), sub-arcsecond imaging with LOFAR to detect outflows in the central regions of local luminous infrared galaxies.
International Nuclear Information System (INIS)
Niita, Koji; Nara, Yasushi; Takada, Hiroshi; Nakashima, Hiroshi; Chiba, Satoshi; Ikeda, Yujiro
1999-09-01
We are developing a nucleon-meson transport code NMTC/JAM, which is an upgraded version of NMTC/JAERI. NMTC/JAM implements the high energy nuclear reaction code JAM for the infra-nuclear cascade part. By using JAM, the upper limits of the incident energies in NMTC/JAERI, 3.5 GeV for nucleons and 2.5 GeV for mesons, are increased drastically up to several hundreds GeV. We have modified the original JAM code in order to estimate the residual nucleus and its excitation energy for nucleon or pion induced reactions by assuming a simple model for target nucleus. As a result, we have succeeded in lowering the applicable energies of JAM down to about 150 MeV. In this report, we describe the main components of JAM code, which should be implemented in NMTC/JAM, and compare the results calculated by JAM code with the experimental data and with those by LAHET2.7 code for proton induced reactions from 150 MeV to several 10 GeV. It has been found that the results of JAM can reproduce quite well the experimental double differential cross sections of neutrons and pions emitted from the proton induced reactions from 150 MeV to several 10 GeV. On the other hand, the results of LAHET2.7 show the strange behavior of the angular distribution of nucleons and pions from the reactions above 4 GeV. (author)
Directory of Open Access Journals (Sweden)
Dorothee Rempfer
2008-03-01
Full Text Available Florence Hervé, Dozentin, freie Journalisten und Autorin, hat in diesem anlässlich des Jubiläums erschienenen Band mit Texten von und über Clara Zetkin einen thematisch gegliederten biographischen Überblick vorgelegt. Hervé ordnet die Politikerin und Frauenrechtlerin anhand der Materialien in historische Zusammenhänge ein und setzt sich kritisch mit ihren Gedanken und Theorien auseinander. Dabei vertritt sie den Anspruch, Zetkin auch von ihren bisher weniger bekannten Seiten zu zeigen. Dies gelingt ihr jedoch nur ansatzweise.Lecturer, independent journalist, and author Florence Hervé provides a thematically structured biographical overview for this volume of texts from and about Clara Zetkin, which appeared in conjunction with the celebration of her 150th birthday. Hervé classifies the politician and women’s right activist according to materials in historical context and critical approaches Zetkin’s thoughts and theories. In so doing, she asserts the necessity of displaying Zetkin’s lesser-known aspects. However, the author only partially achieves this goal.
Energy Technology Data Exchange (ETDEWEB)
Pfeilschifter, J. [Heidelberg Univ., Radiologische Klinik (Germany). Abt. fuer Nuklearmedizin; Elser, H. [Medizinische Universitaetsklinik und Poliklinik Heidelberg (Germany). Abt. fuer Innere Medizin I; Haufe, S. [Medizinische Universitaetsklinik und Poliklinik Heidelberg (Germany). Abt. fuer Innere Medizin I; Ziegler, R. [Heidelberg Univ., Radiologische Klinik (Germany). Abt. fuer Nuklearmedizin; Georgi, P. [Medizinische Universitaetsklinik und Poliklinik Heidelberg (Germany). Abt. fuer Innere Medizin I
1997-04-01
Aim: We examined the impact of several pretreatment variables on thyroid size and function in 61 patients with Graves` disease one year after a standardized [131]I treatment with 150 Gray. Methods: FT3, FT4, and TSH serum concentrations were determined before and 1.5, 3, 6, and 12 months after therapy. Thyroid size was measured by ultrasound and scintigraphy before and one year after therapy. Results: One year after therapy, 30% of the patients had latent or manifest hyperthyroidism, 24% were euthyroid, and 46% had developed latent or manifest hypothyroidism. Age and initial thyroid volume were major predictors of posttherapeutical thyroid function. Thus, persistent hyperthyroidism was observed in 70% of the patients age 50 years and older with a thyroid size of more than 50 ml. With few exception, thyroid size markedly decreased after therapy. Initial thyroid size and age were also major predictors of posttherapeutical thyroid volume. Thyroid size normalized in all patients younger than 50 years of age, independent from initial thyroid size. Conclusion: Radioiodine treatment with 150 Gray causes a considerable decrease in thyroid size in most patients with Graves` disease. Age and initial thyroid volume are important determinants of thyroid function and size after therapy and should be considered in dose calculation. (orig.) [Deutsch] Ziel: Bei 61 Patienten mit einem Morbus Basedow haben wir den Einfluss praetherapeutischer Variablen auf die Funktion und das Volumen der Schilddruese ein Jahr nach einer {sup 131}J-Therapie mit 150 Gray untersucht. Methoden: FT3, FT4, und TSH wurden vor Therapie und eineinhalb, 3, 6 und 12 Monate nach Therapie gemessen. Das Schilddruesenvolumen wurde vor Therapie und ein Jahr nach Therapie sonographisch und szintigraphisch bestimmt. Ergebnisse: Ein Jahr nach Therapie waren 30% der Patienten latent oder manifest hyperthyreot, 24% euthyreot, und 46% latent oder manifest hypothyreot. Lebensalter und Ausgangsvolumen der Schilddruese
International Nuclear Information System (INIS)
Petti, P.L.
1985-01-01
The purpose of this thesis is to provide a 1% measurement of omega, the energy required to produce an ion pair, for 150 MeV protons in various gases. Such a measurement should improve the accuracy of proton ionization chamber dosimetry at the Harvard Cyclotron Laboratory. Currently, no measurements of omega exist in the energy range of 30 to 150 MeV, and present ionization chamber dosimetry at the Cyclotron relies on average values of measurements at lower and higher energies (i.e. for E < 3 MeV and E = 340 MeV). Contrary to theoretical expectations, these low and high energy data differ by as much as 9% in some gases. The results of this investigation demonstrate that the existing high energy data is probably in error, and current proton ionization chamber dosimetry underestimates omega, and hence the proton dose, by 5%
Experimental alteration of R7T7 glass in salt brines at 90 deg C and 150 deg C
International Nuclear Information System (INIS)
Godon, N.; Vernaz, E.; Gin, S.; Beaufort, D.; Thomassin, J.H.
1991-01-01
Static experiments have been developed to investigate the R7T7 glass corrosion in four natural salt brines (brines 1 and 3: pure halite, brines 2 and 4: high Mg, K fluid inclusions rich halite), at 90 deg C and 150 deg C with 0.7 cm -1 S/V ratio and at 11 different running times. Analysis of brines after alteration (pHmeter and ICP) added to a detailed study of the crystalline phases developed at the interface glass-brine (XRD,SEM and Microprobe), showed that the influence of the compositional difference is more important on the nature of the secondary phases formed than on the corrosion rate of the glass. After 91 days of alteration at 150 deg C stady states to be reached (after 40 days at 90 deg C). A long term experiment (1 year) is necessary to confirm this hypothesis. 7 refs., 7 figs., 2 tabs
International Nuclear Information System (INIS)
2013-01-01
This Resolution is about the need to adapt the quality control regulation of liquid carburant approved by Resolution of the URSEA N. 150/2008. ANCAP has informed to URSEA the incorporation and reformularization of alcohol carburant in the gasoline
Full Scale Test on a 100km, 150kV AC Cable
DEFF Research Database (Denmark)
Faria da Silva, Filipe Farria; Wiechowski, W.; Bak, Claus Leth
2010-01-01
phenomena is conducted. The cases analysed in this paper are: Zero-missing phenomenon, Ferranti effect, energisation transient, effect of the cable's connection in the busbar voltage and cable disconnection. For all the phenomena described in the paper measurement data are presented and it is verified......This paper presents some of the results obtained from the electrical measurements on a 99.7 km, 150 kV three-phase AC cable, connecting 215 MW offshore wind farm Horns Rev 2, located in Denmark west coast, to Denmark's 400 kV transmission network. The measurements were performed at nominal voltage...... if the obtained results are in accordance with the theory and also with simulations performed in PSCAD/EMTDC. With the exception of the cable disconnection, for all the remaining cases introduced in this paper the measurements confirmed the theoretical expectations. Depending on the cable disconnection sequence...
Czech Academy of Sciences Publication Activity Database
Almáši, M.; Zeleňák, V.; Opanasenko, Maksym; Císařová, I.
2015-01-01
Roč. 243, APR 2015 (2015), s. 184-194 ISSN 0920-5861 R&D Projects: GA ČR GA14-07101S Institutional support: RVO:61388955 Keywords : cerium(III) * lutetium(III) * Benzene-1,3,5-tricarboxylate Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.312, year: 2015
The high squareness Sm-Co magnet having Hcb=10.6 kOe at 150°C
Directory of Open Access Journals (Sweden)
Hiroaki Machida
2017-05-01
Full Text Available The relationship between magnetic properties and magnetic domain structures of Sm(Fe, Cu, Zr, Co7.5 magnet was investigated. The developed Sm-Co magnet, which is conducted homogenization heat treatment at ingot state, high temperature short time sintering and long time solid solution heat treatment showed the maximum energy product, [BH]m of 34.0 MGOe and the coercivity, Hcb of 11.3 kOe at 20°C respectively. Moreover, Hcb of 10.6 kOe at 150°C was achieved. Heat treated ingot has clear 1-7 phase in mother phase from optical microscope observation. Kerr effect microscope with magnetic field applied was used to investigate magnetic domain structure. Reverse magnetic domains were generated evenly but generation of them from inside grain were not observed. Cell structure was observed by scanning transmission electron microscope and composition analysis was conducted by energy dispersive X-ray spectroscopy. Cell size was approximately 150 ∼ 300 nm, Fe and Cu were clearly separated and concentrated to 2-17 phase and 1-5 phase respectively. Moreover, Cu concentration went up to 40 at% in 1-5 phase. That means the gap of domain wall energy between 1-5 phase and 2-17 phase was increased due to microstructure control by conducting heat treatment for compositional homogeneity.
Directory of Open Access Journals (Sweden)
Andita Noor Shafira
2017-01-01
Full Text Available Listrik merupakan suatu kebutuhan mutlak yang harus dipenuhi untuk menjamin keberlangsungan hidup masyarakat masa kini. Kebutuhan ini terus meningkat seiring dengan pertumbuhan beban yang semakin bertambah dari tahun ke tahun. Pertumbuhan beban yang diikuti dengan peningkatan permintaan suplai daya reaktif akibat beban bersifat induktif meningkat menyebabkan perencanaan dan operasi dari sistem interkoneksi menjadi lebih kompleks sehingga kualitas sistem menjadi kurang dapat diandalkan. Aliran daya reaktif dapat menyebabkan drop tegangan dan kerugian daya dalam sistem transmisi. Untuk itu dilakukan penentuan letak dan kapasitas kapasitor shunt untuk mengurangi kerugian daya dengan menggunakan Newton-Raphson dan metode optimisasi Artificial Bee Colony Algorithm. Pada percobaan ini dilakukan pemasangan lima kapasitor dengan jumlah koloni sebesar 50 dan Max Cycle Number sebesar 150. Hasil simulasi menggunakan metode Artificial Bee Colony Algorithm menunjukkan bahwa pemasangan kapasitor pada Jaring Transmisi 150 kV Sumatera Utara dapat menurunkan kerugian daya aktif sebesar 8,37%.
Pi, Jiang; Jin, Hua; Jiang, Jinhuan; Yang, Fen; Cai, Huaihong; Yang, Peihui; Cai, Jiye; Chen, Zheng W
2017-05-01
As the active anticancer component of Rabdosia Rubescens, oridonin has been proved to show strong anticancer activity in cancer cells, which is also found to be closely related to its specific inhibition effects on the EGFR tyrosine kinase activity. In this study, atomic force microscopy based single molecule force spectroscopy (AFM-SMFS) was used for real-time and in-situ detection of EGF-EGFR interactions in living esophageal cancer KYSE-150 cells to evaluate the anticancer activity of oridonin for the first time. Oridonin was found to induce apoptosis and also reduce EGFR expression in KYSE-150 cells. AFM-SMFS results demonstrated that oridonin could inhibit the binding between EGF and EGFR in KYSE-150 cells by decreasing the unbinding force and binding probability for EGF-EGFR complexes, which was further proved to be closely associated with the intracellular ROS level. More precise mechanism studies based on AFM-SMFS demonstrated that oridonin treatment could decrease the energy barrier width, increase the dissociation off rate constant and decrease the activation energy of EGF-EGFR complexes in ROS dependent way, suggesting oridonin as a strong anticancer agent targeting EGF-EGFR interactions in cancer cells through ROS dependent mechanism. Our results not only suggested oridonin as a strong anticancer agent targeting EGF-EGFR interactions in ROS dependent mechanism, but also highlighted AFM-SMFS as a powerful technique for pharmacodynamic studies by detecting ligand-receptor interactions, which was also expected to be developed into a promising tool for the screening and mechanism studies of drugs. Copyright © 2016 Elsevier Ltd. All rights reserved.
Directory of Open Access Journals (Sweden)
Lilia GÎRLA
2016-11-01
Full Text Available Scopul acestui studiu constă în: cercetarea ştiinţifică a portretului psihologic al victimei determinării la sinucidere (art.150 CP RM prin oferirea explicaţiilor psihologo-psihiatrice, precum şi medico-legale relevante momentului formării şi luării deciziei suicidare la victimă. În special, mesajul este dedicat aspectelor contradictorii de delimitare a suicidului voluntar, a determinării la sinucidere de omorul intenţionat al victimei săvârşit prin forţa lui fizică. În acest sens, autorul a aderat la opiniile doctrinare care promovează ideea că factorii interni (cum ar fi patologia psihiatrică la victimă este una determinativă la săvârşirea actului suicidar „voluntar”, iar factorii sociali (externi sunt caracteristici determinării la sinucidere în sensul art.150 CP RM, cu condiţia că aceşti factori sunt „necesari” şi „suficienţi” (condiţie sine qua non pentru luarea deciziei suicidare. În cazul în care decizia de a se sinucide nu se află în legătură de cauzalitate cu comportamentul făptuitorului, fiind o reacţie imprevizibilă, irelevantă şi excesivă, componenţa infracţională prevăzută la art.150 CP RM va lipsi. Problema sinuciderii în cadrul eutanasiei nu constituie obiectul de cercetare al acestui articol.Pentru a obţine concluzii relevante şi superioare celor precedente în doctrină, se va purcede la o analiză multiaspectuală a conceptului de suicid, la o abordare pluridisciplinară (drept penal, psihologie, psihiatrie, medicina legală, criminologie, sociologie a acestui fenomen, precum şi vor fi utilizate anumite concluzii relevante din practica CtEDO, practica judiciară a Republicii Moldova şi cea a României.victim of the inducement to suicide (art.150 Cc rm: psychological and psychiatric explanations concerning the final decision-making in the suicideThe basic purpose of present study consists in scientific research of the psychological portrait of
Future Automotive Aftertreatment Solutions: The 150°C Challenge Workshop Report
Energy Technology Data Exchange (ETDEWEB)
Zammit, Michael; DiMaggio, Craig L.; Kim, Chang H.; Lambert, Christine; Muntean, George G.; Peden, Charles HF; Parks, James E.; Howden, Ken
2013-10-15
With future fuel economy standards enacted, the U.S. automotive manufacturers (OEMs) are committed to pursuing a variety of high risk/highly efficient stoichiometric and lean combustion strategies to achieve superior performance. In recognition of this need, the U.S. Department of Energy (DOE) has partnered with domestic automotive manufacturers through U.S. DRIVE to develop these advanced technologies. However, before these advancements can be introduced into the U.S. market, they must also be able to meet increasingly stringent emissions requirements. A significant roadblock to this implementation is the inability of current catalyst and aftertreatment technologies to provide the required activity at the much lower exhaust temperatures that will accompany highly efficient combustion processes and powertrain strategies. Therefore, the goal of this workshop and report is to create a U.S. DRIVE emission control roadmap that will identify new materials and aftertreatment approaches that offer the potential for 90% conversion of emissions at low temperature (150°C) and are consistent with highly efficient combustion technologies currently under investigation within U.S. DRIVE Advanced Combustion and Emission Control (ACEC) programs.
International Nuclear Information System (INIS)
Bhatnagar, Parijat; Panda, Siddhartha; Edleman, Nikki L.; Allen, Scott D.; Wise, Richard; Mahorowala, Arpan
2007-01-01
We have developed a reactive ion etch (RIE) process in borophosphosilicate glass (BPSG) for 150 nm line-and-space features, where line-edge roughness (LER) complemented with RIE lag becomes a major issue. Effect of flow rates and carbon-to-fluorine atomic ratio of fluorohydrocarbon gases was utilized to achieve acceptable process window allowing lower radio frequency powers therefore obtaining acceptable LER and RIE lag in the high-resolution features etched into BPSG
Competition between pairing and quadrupole deformation in the yrast sequence of sup(150,152)Dy
International Nuclear Information System (INIS)
Aberg, S.
1984-05-01
The yrast spectra are investigated for the non-collective nuclei sup(150,152)Dy using the Nilsson-Strutinsky + blocked BCS model. The separate effects from the pairing force and the quadrupole force (deformation changes) are studied. It is found that the pairing force is most important in describing the yrast line up to Iproportional30, while the quadrupole force is most important for I> or approx.20. The calculated increase of the oblate deformation with increasing spin is explained as an antipairing effect when only valence nucleons are building the total spin and as a polarization effect when the core becomes excited. (orig.)
Maloney, K C; Ferguson, T S; Stewart, H D; Myers, A A; De Ceulaer, K
2017-11-01
Background Epidemiological studies in systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups. Although systemic lupus erythematosus in Jamaica has been described in the past, there has not been a detailed evaluation of systemic lupus erythematosus patients in urban Jamaica, a largely Afro-Caribbean population. The goal of this study was to describe the clinical features, particularly disease activity, damage index and immunological features, of 150 systemic lupus erythematosus subjects. Methods 150 adult patients (≥18 years) followed in rheumatology clinic at a tertiary rheumatology hospital centre (one of two of the major public referral centres in Jamaica) and the private rheumatology offices in urban Jamaica who fulfilled Systemic Lupus International Collaborating Clinics (SLICC) criteria were included. Data were collected by detailed clinical interview and examination and laboratory investigations. Hence demographics, SLICC criteria, immunological profile, systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) and SLICC/American College of Rheumatology (ACR) damage index (SDI) were documented. Results Of the 150 patients, 145 (96.7%) were female and five (3.3%) were male. The mean age at systemic lupus erythematosus onset was 33.2 ± 10.9. Mean disease duration was 11.3 ± 8.6 years. The most prevalent clinical SLICC criteria were musculoskeletal, with 141 (94%) of subjects experiencing arthralgia/arthritis, followed by mucocutaneous manifestations of alopecia 103 (68.7%) and malar rash 46 (30.7%), discoid rash 45 (30%) and photosensitivity 40 (26.7%). Lupus nephritis (biopsy proven) occurred in 42 (28%) subjects and 25 (16.7%) met SLICC diagnostic criteria with only positive antinuclear antibodies/dsDNA antibodies and lupus nephritis on renal biopsy. The most common laboratory SLICC criteria were positive antinuclear antibodies 136 (90.7%) followed by anti-dsDNA antibodies 95 (63.3%) and
Rachman, Noviadi Arief; Risdiyanto, Agus; Ramdan, Ade
2013-01-01
Charge Simulation Method is one of the field theory that can be used as an approach to calculate the electromagnetic distribution on the electrical conductor. This paper discussed electric field modeling around power transformator by using Matlab to find the safety distance. The safe distance threshold of the electric field to human health refers to WHO and SNI was 5 kV/m. The specification of the power transformator was three phases, 150/20 kV, and 100 MVA. The basic concept is to change the...
How the Sun Knocks Out My Cell Phone from 150 Million Kilometers Away
Ladbury, Ray
2014-01-01
Large solar particle events (SPE) threaten many elements of critical infrastructure. A 2013 study by Lloyds of London and Atmospheric and Environmental Research recently found that if a worst-case solar event like the 1859 Carrington Event struck our planet now, it could result on $0.6-$2.36 trillion in damages to the economy. In March 2014, researchers Y. D. Liu et al. revealed that just such an event had narrowly missed Earth in July 2012. The event was observed by the STEREO A spacecraft. In this presentation, we examine how the sun can pack such a punch from 150 million km away, the threats such solar particle events pose, their mechanisms and the efforts NASA and other space agencies are carrying out to understand and mitigate such risks.
Effects of electronic excitation in 150 keV Ni ion irradiation of metallic systems
Zarkadoula, Eva; Samolyuk, German; Weber, William J.
2018-01-01
We use the two-temperature model in molecular dynamic simulations of 150 keV Ni ion cascades in nickel and nickel-based alloys to investigate the effect of the energy exchange between the atomic and the electronic systems during the primary stages of radiation damage. We find that the electron-phonon interactions result in a smaller amount of defects and affect the cluster formation, resulting in smaller clusters. These results indicate that ignoring the local heating due to the electrons results in the overestimation of the amount of damage and the size of the defect clusters. A comparison of the average defect production to the Norgett-Robinson-Torrens (NRT) prediction over a range of energies is provided.
Energy Technology Data Exchange (ETDEWEB)
Rossi, P; Pavone, P; Castrucci, M; Piscitelli, G
1988-05-01
The results of a comparative double-blind clinical trial involving peripheral intra-arterial DSA performed with low iodine iopamidol concentrations (150 and 200 mg. I/ml) are reported. Forty-six patients were examined for vital signs, local (heat and pain sensations) and systemic reactions and monitored throughout the procedure. No untoward effect was observed apart from mild local reactions, which on the other hand did not produce any movement artifacts. Image quality was good to optimal in 98% of the cases. In no case were higher concentrations of contrast medium (cm) needed. No significant differences between the two concentrations of cm used were observed with respect to either contrast ability of tolerability.
Two neutrino double-β decay of 94 ≤ A ≤ 150 nuclei for the 0{sup +} → 2{sup +} transition
Energy Technology Data Exchange (ETDEWEB)
Singh, Yash Kaur; Chandra, R. [Babasaheb Bhimrao Ambedkar University, Department of Applied Physics, Lucknow (India); Raina, P.K. [Indian Institute of Technology, Department of Physics, Ropar, Rupnagar (India); Rath, P.K. [University of Lucknow, Department of Physics, Lucknow (India)
2017-12-15
Within the PHFB approach, the 0{sup +} → 2{sup +} transition of two neutrino double-β decay of {sup 94,96}Zr, {sup 100}Mo, {sup 104}Ru, {sup 110}Pd, {sup 128,130}Te and {sup 150}Nd isotopes is studied employing wave functions generated with four different parametrizations of the pairing plus multipole type of two-nucleon interaction and the summation method. In comparison to the 0{sup +} → 0{sup +} transition, the nuclear transition matrix elements M{sub 2ν} (2{sup +}) are quite sensitive to the deformation of the yrast 2{sup +} state. Consideration of the available theoretical and experimental results suggests that the observation of the 0{sup +} → 2{sup +} transition of 2νβ{sup -}β{sup -} decay may be possible in {sup 96}Zr, {sup 100}Mo, {sup 130}Te and {sup 150}Nd isotopes. The effect of deformation on the M{sub 2ν} (2{sup +}) is also studied. (orig.)
Directory of Open Access Journals (Sweden)
Kyle T Greenway
Full Text Available Neuraminidase inhibitors are the main pharmaceutical agents employed for treatments of influenza infections. The neuraminidase structures typically exhibit a 150-cavity, an exposed pocket that is adjacent to the catalytic site. This site offers promising additional contact points for improving potency of existing pharmaceuticals, as well as generating entirely new candidate inhibitors. Several inhibitors based on known compounds and designed to interact with 150-cavity residues have been reported. However, the dynamics of any of these inhibitors remains unstudied and their viability remains unknown. This work reports the outcome of long-term, all-atom molecular dynamics simulations of four such inhibitors, along with three standard inhibitors for comparison. Each is studied in complex with four representative neuraminidase structures, which are also simulated in the absence of ligands for comparison, resulting in a total simulation time of 9.6 µs. Our results demonstrate that standard inhibitors characteristically reduce the mobility of these dynamic proteins, while the 150-binders do not, instead giving rise to many unique conformations. We further describe an improved RMSD-based clustering technique that isolates these conformations--the structures of which are provided to facilitate future molecular docking studies--and reveals their interdependence. We find that this approach confers many advantages over previously described techniques, and the implications for rational drug design are discussed.
Ultrafine coal classification using 150 mm gMax cyclone circuits
Energy Technology Data Exchange (ETDEWEB)
Honaker, R.Q.; Boaten, F.; Luttrell, G.H. [University of Kentucky, Lexington, KY (United States). Dept. of Mineral Engineering
2007-11-15
A two-stage classification circuit using 150 mm diameter gMax cyclones was installed and evaluated in a coal preparation plant in an effort to achieve a clean coal product without the use of froth flotation. Particle size separations of around 37 {mu}m were achieved while limiting ultrafine bypass to less than 10% in the circuit underflow stream. As a result, approximately 81% of the ash-bearing material in the circuit feed was rejected to the circuit overflow stream. The feed ash content was reduced from around 50% to values in the range of 22-30% in the circuit underflow stream with a mass recovery of about 30%. Further reductions in the coarse product ash content were limited due to the particle density effect and the remaining presence of a significant quantity of high-ash slime material in the coarse product. The typical D{sub 50} for the coal particles was 40 {mu} m while the estimated value for mineral matter was 17 {mu} m. Based on the findings of the study, the use of classification to recover a low-ash, coarse fraction in the feed of a fine coal circuit is limited by the density effect regardless of the ability to eliminate ultrafine bypass.
Czech Academy of Sciences Publication Activity Database
Jarý, Vítězslav; Nikl, Martin; Kurosawa, S.; Shoji, Y.; Mihóková, Eva; Beitlerová, Alena; Pazzi, G.P.; Yoshikawa, A.
2014-01-01
Roč. 118, č. 46 (2014), s. 26521-26529 ISSN 1932-7447 R&D Projects: GA MŠk(CZ) LH14266 Institutional support: RVO:68378271 Keywords : lutetium silicate sci ntillators * floating-zone growth * electronic-structure * yttrium content * lyso crystals Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 4.772, year: 2014
DEFF Research Database (Denmark)
Allebrod, Frank; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg
2014-01-01
A new type of alkaline electrolysis cells with nickel foam based gas diffusion electrodes and KOH (aq) immobilized in mesoporous SrTiO3 has been developed and tested at temperatures of 150 C, 200 C and 250 C at a pressure of 40 bar. Two cells have been characterized during the 270 h long test...
Kenney, Jessica; Singer, Rachel; Derby, Nina; Aravantinou, Meropi; Abraham, Ciby J; Menon, Radhika; Seidor, Samantha; Zhang, Shimin; Gettie, Agegnehu; Blanchard, James; Piatak, Michael; Lifson, Jeffrey D; Fernández-Romero, José A; Zydowsky, Thomas M; Robbiani, Melissa
2012-11-01
Previously we showed that repeated vaginal application of a MIV-150/zinc acetate carrageenan (MIV-150/ZA/CG) gel and a zinc acetate carrageenan (ZA/CG) gel significantly protected macaques from vaginal simian human immunodeficiency virus reverse transcriptase (SHIV-RT) infection. Gels were applied either daily for 2 weeks or every other day for 4 weeks, and the animals were challenged 4-24 h later. Herein, we examined the effects of a single vaginal dose administered either before or after virus challenge. Encouraged by the vaginal protection seen with MIV-150/ZA/CG, we also tested it rectally. Vaginal applications of MIV-150/ZA/CG, ZA/CG, and CG gel were performed once 8-24 h before, 1 h after, or 24 h before and 1 h after vaginal challenge. Rectal applications of MIV-150/ZA/CG and CG gel were performed once 8 or 24 h before rectal challenge. While vaginal pre-challenge and pre/post-challenge application of MIV-150/ZA/CG gel offered significant protection (88%, pinfection prechallenge, but not significantly, and the effect was completely lost post-challenge. Rectal application of MIV-150/ZA/CG gel afforded limited protection against rectal challenge when applied 8-24 h before challenge. Thus, MIV-150/ZA/CG gel is a highly effective vaginal microbicide that demonstrates 24 h of protection from vaginal infection and may demonstrate efficacy against rectal infection when given close to the time of HIV exposure.
International Nuclear Information System (INIS)
Dinh, Tru-Khang T.; Fendler, Wojciech; Chałubińska-Fendler, Justyna; Acharya, Sanket S.; O’Leary, Colin; Deraska, Peter V.; D’Andrea, Alan D.; Chowdhury, Dipanjan; Kozono, David
2016-01-01
Risk of normal tissue toxicity limits the amount of thoracic radiation therapy (RT) that can be routinely prescribed to treat non-small cell lung cancer (NSCLC). An early biomarker of response to thoracic RT may provide a way to predict eventual toxicities—such as radiation pneumonitis—during treatment, thereby enabling dose adjustment before the symptomatic onset of late effects. MicroRNAs (miRNAs) were studied as potential serological biomarkers for thoracic RT. As a first step, we sought to identify miRNAs that correlate with delivered dose and standard dosimetric factors. We performed miRNA profiling of plasma samples obtained from five patients with Stage IIIA NSCLC at five dose-points each during radical thoracic RT. Candidate miRNAs were then assessed in samples from a separate cohort of 21 NSCLC patients receiving radical thoracic RT. To identify a cellular source of circulating miRNAs, we quantified in vitro miRNA expression intracellularly and within secreted exosomes in five NSCLC and stromal cell lines. miRNA profiling of the discovery cohort identified ten circulating miRNAs that correlated with delivered RT dose as well as other dosimetric parameters such as lung V20. In the validation cohort, miR-29a-3p and miR-150-5p were reproducibly shown to decrease with increasing radiation dose. Expression of miR-29a-3p and miR-150-5p in secreted exosomes decreased with radiation. This was concomitant with an increase in intracellular levels, suggesting that exosomal export of these miRNAs may be downregulated in both NSCLC and stromal cells in response to radiation. miR-29a-3p and miR-150-5p were identified as circulating biomarkers that correlated with delivered RT dose. miR-150 has been reported to decrease in the circulation of mammals exposed to radiation while miR-29a has been associated with fibrosis in the human heart, lungs, and kidneys. One may therefore hypothesize that outlier levels of circulating miR-29a-3p and miR-150-5p may eventually help
Magnetic structures of holmium-lutetium alloys and superlattices
DEFF Research Database (Denmark)
Swaddling, P.P.; Cowley, R.A.; Ward, R.C.C.
1996-01-01
Alloys and superlattices of Ho and Lu have been grown using molecular beam epitaxy and their magnetic structures determined using neutron-scattering techniques. The 4f moments in the alloys form a helix at all compositions with the moments aligned in the basal plane perpendicular to the wave vector...... of the helix remaining coherent through the nonmagnetic Lu blocks. The neutron scattering from the superlattices is consistent with a model in which there are different phase advances of the helix turn angle through the Ho and Lu blocks, but with a localized moment on the Ho sites only. A comparison...... of Ho and Lu. At low temperatures, for superlattices with fewer than approximately twenty atomic planes of Ho, the Ho moments within a block undergo a phase transition from helical to ferromagnetic order, with the coupling between successive blocks dependent on the thickness of the Lu spacer....
E2,M1 multipole mixing ratios in even-even nuclei, 58< or =A< or =150
International Nuclear Information System (INIS)
Krane, K.S.
1977-01-01
A survey is presented of E2,M1 multipole mixing ratios of gamma-ray transitions in even-even nuclei in the mass range 58< or =A< or =150. Angular distribution and correlation data from the literature are analyzed in terms of a consistent choice of the phase relationship between the E2 and M1 matrix elements. A set of recommended values of the mixing ratios is included based on averages of results from various studies. The survey includes data available in the literature up to December 1976
Luhmann, Andrew J.; Tutolo, Benjamin M.; Bagley, Brian C.; Mildner, David F. R.; Scheuermann, Peter P.; Feinberg, Joshua M.; Ignatyev, Konstantin; Seyfried, William E.
2017-10-01
Two flow-through experiments were conducted to assess serpentinization of intact dunite cores. Permeability and fluid chemistry indicate significantly more reaction during the second experiment at 200 °C than the first experiment at 150 °C. Permeability decreased by a factor of 2.4 and 25 during the experiments at 150 and 200 °C, respectively. Furthermore, hydrogen and methane concentrations exceeded 600 μmol/kg and 300 μmol/kg during the 200 °C experiment, and were one and two orders of magnitude higher, respectively, than the 150 °C experiment. Fe K-edge X-ray absorption near edge structure analyses of alteration minerals demonstrated Fe oxidation that occurred during the 200 °C experiment. Vibrating sample magnetometer measurements on post-experimental cores indicated little to no magnetite production, suggesting that the hydrogen was largely generated by the oxidation of iron as olivine was converted to ferric iron (Fe(III)) serpentine and/or saponite. Scanning electron microscopy images suggested secondary mineralization on the post-experimental core from the 200 °C experiment, portraying the formation of a secondary phase with a honeycomb-like texture as well as calcite and wollastonite. Scanning electron microscopy images also illustrated dissolution along linear bands through the interiors of olivine crystals, possibly along pathways with abundant fluid inclusions. Energy dispersive X-ray spectroscopy identified Cl uptake in serpentine, while Fourier transform-infrared spectroscopy suggested the formation of serpentine, saponite, and talc. However, no change was observed when comparing pre- and post-experimental X-ray computed tomography scans of the cores. Furthermore, (ultra) small angle neutron scattering datasets were collected to assess changes in porosity, surface area, and fractal characteristics of the samples over the ≈ 1 nm- to 10 μm-scale range. The results from the 200 °C post-experimental core generally fell within the range of
Evaluation of n+Mn-55 cross section data up to 150 MeV neutron energy
International Nuclear Information System (INIS)
Pereslavtsev, P.; Fischer, U.
2008-01-01
A new evaluation was performed for the reaction system n + 55 Mn in the neutron energy range from 0.001 to 150 MeV. The evaluation is based on the use of the ECIS96 and GNASH codes. A good description of available experimental data was achieved. A very limited set of existing evaluated data from the available international nuclear data libraries was used for the evaluation. The final general purpose data file was prepared in standard ENDF-6 format and was verified with standard format checking utilities. The data file will undergo benchmark testing and will be finally integrated into the JEFF-3.2 data library. (authors)
A study on the safety of TBP(150A) with forming analysis and strength test
International Nuclear Information System (INIS)
Lee, Sung Ho; Kim, Hei Song
2008-01-01
For this study, the forming analyses and body strength tests of TBP were performed on the main pipe size 150A(KS D3507, KS D 3576 10S). The branched pipe sizes utilized were 25A, 32A, 40A, 50A, 65A, 80A, 100A and 125A. A general FEM program, ABAQUS, was used as the forming analyses method of TBP. Using the results, the strength of TBP was then tested in order to determine the safety of TBP when the working pressure was applied. The results indicate that TBP may be safely used in water-based fire protection pipe systems in terms of the strength
Para-ter-butyl of calix(4)arene with acetamide-ether as inorganic-organic receiver
International Nuclear Information System (INIS)
Ramirez, F.M. de; Scopelliti, R.; Muller, G.; Buenzli J, C.G.; Charbonniere, L.
2001-01-01
A new functionalized calix(4)arene was designed and constructed with predetrmined properties to form lanthanides complexes and to sensibilize its luminescent properties. This, in addition to sensibilize that photophysical property and once formed the complex resulted a good receiver of organic molecules as it is demonstrated the crystal structure of the lutetium complex. (Author)
Czech Academy of Sciences Publication Activity Database
Pejchal, Jan; Babin, Vladimir; Beitlerová, Alena; Kučerková, Romana; Pánek, D.; Barta, J.; Čuba, V.; Yamaji, A.; Kurosawa, S.; Mihóková, Eva; Ito, A.; Goto, T.; Nikl, Martin; Yoshikawa, A.
2016-01-01
Roč. 53, Mar (2016), s. 54-63 ISSN 0925-3467 R&D Projects: GA ČR GA13-09876S; GA MŠk(CZ) LH14266 Institutional support: RVO:68378271 Keywords : lutetium-aluminium-garnet * spark-plasma-sintering * nanoceramics * scintillator * Ce-doping Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.238, year: 2016
The evolution of deserts with climatic changes in China since 150 ka B.P.
Institute of Scientific and Technical Information of China (English)
董光荣; 陈惠忠; 王贵勇; 李孝泽; 邵亚军; 金炯
1997-01-01
According to the bioclimatic zones, dune mobility and the fabric characteristics of stratigraphic sedimentary facies, the deserts in China are divided into Eastern, Western, Central and Northwestern deserts. Based on the records of stratigraphical facies, climatic proxies, historical data, etc. in each desert region, the evolution of deserts with climatic changes in time and space since 150 ka B. P. in China are dealt with; then the evolution of deserts in relation to the glacial climatic fluctuations caused by solar radiation changes, underlying surface variation and their feedback mechanism is discussed through comparison with global records; finally, in consideration of global wanning due to increasing of greenhouse gases such as CO2, the possible tendency of the evolution of deserts and the climatic changes is discussed.
A portable Compton spectrometer for clinical X-ray beams in the energy range 20-150 keV
International Nuclear Information System (INIS)
Vieira, A.A.; Linke, A.; Yoshimura, E.M.; Terini, R.A.; Herdade, S.B.
2011-01-01
Primary beam spectra were obtained for an X-ray industrial equipment (40-150 kV), and for a clinical mammography apparatus (25-35 kV) from beams scattered at angles close to 90 o , measured with a CdTe Compton spectrometer. Actual scattering angles were determined from the Compton energy shift of characteristic X-rays or spectra end-point energy. Evaluated contribution of coherent scattering amounts to more than 15% of fluence in mammographic beams. This technique can be used in clinical environments.
Vries, de W.; Leeters, E.E.J.M.
2001-01-01
A nationwide assessment of the chemical composition of the humus layer, mineral topsoil (0-30 cm) and soil solution in both topsoil and subsoil (60-100 cm) was made for 150 forest stands in the year 1990. The stands, which were part of the national forest inventory on vitality, included seven tree
Energy Technology Data Exchange (ETDEWEB)
Lima, Clarice Maria de
2011-07-01
Malignant gliomas are primary brain tumors, resistant to various treatments, as chemotherapy, radiotherapy, induction of apoptosis and surgery. An alternative for the treatment of malignant gliomas is the radionuclide therapy. This technique apply radiolabeled molecules that selectively bind to tumor cells producing cytotoxic effect by dose irradiation, and resulting in death of tumor cells. Most protocols for radionuclide therapy of malignant brain tumors involve the administration of peptides labeled with {beta}{sup -} emitting radioisotopes. The Substance P (SP) is an 11- amino acid neuropeptide, characterized by the C-terminal sequence Phe-X-Gly-Leu-Met-NH{sub 2}. The use of SP labeled with different radionuclides including {sup 177}Lu, have been proposed for in vivo treatment of tumors. SP is the most important target of neurokinin 1 receptors, over expressed in malignant gliomas. The objective of this work was to study conditions of radiolabeling DOTA-SP with {sup 177}Lu, the stability of labeled compound and in vivo and in vitro, to develop a protocol production and evaluate the potential of the radiopharmaceutical in the therapy of gliomas. The labeling conditions were optimized varying the temperature, reaction time, activity of lutetium-177 chloride and mass of DOTA-SP. The radiochemical purity of preparations were analyzed by chromatographic techniques. The stability of {sup 17L}u -DOTA- SP radiolabeled with low activity of {sup 177}Lu was evaluated for different time at 2-8 degree C or incubated in human serum. The stability of the labeled with high activity of {sup 177}Lu was also analyzed in the presence of gentisic acid (6 mg / mL) added after the labeling reaction. The labeled conditions in low and high activity were subjected to evaluation for the ability to cause oxidation of methionine residue, adding the D-L- methionine amino acid to the reaction medium (6 mg / mL) and subsequent chromatographic evaluation. In vitro study with {sup 177}Lu
Directory of Open Access Journals (Sweden)
Tiago Nunes da Silva
2018-04-01
Full Text Available Non-functional pancreatic neuroendocrine tumours (NETs can present with advanced local or distant (metastatic disease limiting the possibility of surgical cure. Several treatment options have been used in experimental neoadjuvant settings to improve the outcomes in such cases. Peptide receptor radionuclide therapy (PPRT using beta emitting radiolabelled somatostatin analogues has been used in progressive pancreatic NETs. We report a 55-year-old female patient with a 12.8 cm pancreatic NET with significant local stomach and superior mesenteric vein compression and liver metastases. The patient underwent treatment with [177Lutetium-DOTA0,Tyr3]octreotate (177Lu-octreotate for the treatment of local and metastatic symptomatic disease. Six months after 4 cycles of 177lutetium-octreotate, resolution of the abdominal complaints was associated with a significant reduction in tumour size and the tumour was rendered operable. Histology of the tumour showed a 90% necrotic tumour with abundant hyalinized fibrosis and haemorrhage compatible with PPRT-induced radiation effects on tumour cells. This report supports that PPRT has a role in unresectable and metastatic pancreatic NET.
The Properties of Sintered Calcium Phosphate with [Ca]/[P] = 1.50
Directory of Open Access Journals (Sweden)
Moo-Chin Wang
2012-10-01
Full Text Available In order to obtain the properties of the sintered as-dried calcium phosphate with [Ca]/[P] = 1.50, the characteristics of sintered pellets have been investigated using X-ray diffraction (XRD, inductively coupled plasma-mass spectrometry (ICP-MS, Fourier-transform infrared (FT-IR spectra, Vickers hardness indentation and scanning electron microscopy (SEM. When the pellet samples were sintered between 700 °C and 1200 °C for 4 h, the hydroxyapatite (Ca10(PO46(OH2, HA still maintained the major phase, accompanied with the rhenanite (NaCaPO4 as the secondary phase and β-tricalcium phosphate (β-Ca3(PO42, β-TCP as the minor phases. In addition, the HA partially transformed to α-tricalcium phosphate (α-Ca3(PO42, α-TCP and tetracalcium phosphate (Ca4(PO42O, TTCP, when the pellet samples were sintered at 1300 °C and 1400 °C, respectively, for 4 h. The maximum density and Vickers Hardness (HV of sintered pellet samples were 2.85 g/cm3 (90.18% theoretical density (T.D. and 407, which appeared at 1200 °C and 900 °C, respectively.
Fink, D; Hotchkis, M
2000-01-01
We have measured the low-energy yield of sup 3 sup 6 Cl from Ti for proton energies from 35 to 150 MeV. Thin Ti foil irradiations were performed at the Harvard University Cyclotron Laboratory and sup 3 sup 6 Cl concentrations were determined using the ANTARES AMS facility at ANSTO. Cross-sections ranged smoothly with energy from 0.32+-0.05 mb at 35 MeV to 5.3+-0.4 mb at 150 MeV. Results for E<110 MeV are new, while the upper region from 110 to 150 MeV agrees well with overlapping data from other studies. The in-situ production rate for sup 3 sup 6 Cl from Ti at the earth's surface and high latitude based on this excitation function and calculations of Masarik and Reedy (normalised to the mean measured yield of sup 3 sup 6 Cl from Ca) is estimated at approx(13+-3) atoms sup 3 sup 6 Cl (g Ti yr) sup - sup 1. We thus conclude that in Ti-rich, Ca-poor rocks or in typical basalts, sup 3 sup 6 Cl yield from Ti can amount to approx 5-10% of total. This is similar to the contribution from slow muon capture on sup ...
Study of the effects of a prenatal or postnatal irradiation of 150 rads in adult rats
International Nuclear Information System (INIS)
Coffigny, H.; Pasquier, C.
Pregnant females and newborn rats were exposed to a gamma irradiation of 150 rads. The stage of gestation at the time of irradiation varied from 14 to 21 days. The newborn rats were irradiated at 0, 1 and 2 days of age. The effect of irradiation of foetus and newborn rats depends on the age of the animal at the time of irradiation. This effect was specially important at the beginning of the foetal life. Neonatal mortality, growth of body weight and adult brain development were investigated. A modification of germ cell radiosensitivity during the period studied, was emphasized [fr
International Nuclear Information System (INIS)
Brittingham, J.N.
1979-01-01
The feasibility of using magnetic-gradient and electrostatic accelerators to launch a 0.1-g projectile to hypervelocities (150 km/s or more) is studied. Such hypervelocity projectiles could be used to ignite deuterium-tritium fuel pellets in a fusion reactor. For the magnetic-gradient accelerator, several types of projectile were studied: shielded and unshielded copper, ferromagnetic, and superconducting. The calculations revealed the superconducting projectile to be the best of those materials. It would require a 3.2-km-long magnetic-gradient accelerator and achieve a 92% efficiency. This accelerator-projectile combination would be the one most likely to launch a 0.1-g projectile to 150 km/s or more. Its components would cost $58.9 million. The electrostatic accelerator was found to be impractical because of its excessive length of 23 km
Application of the pM'-pCH diagrams in the determination of hydrolysis constants of the lanthanides
International Nuclear Information System (INIS)
Lopez G, H.; Jimenez R, M.; Solache R, M.; Rojas H, A.
2001-01-01
The pM ' -pC H diagrams allowed to determine the saturation and non-saturation zones of Lu(OH) 3 in solid phase and those were applied for determining the hydrolysis and lutetium solubility constants, using the radioactive isotope Lu-177. The first constant of hydrolysis was also determined by the potentiometric method in absence of solid phase. (Author)
International Nuclear Information System (INIS)
Yamshchikov, L.F.; Zyapaev, A.A.; Raspopin, S.P.
2003-01-01
Published data on thermodynamic characteristics of lanthanides in liquid-metal melts of gallium, indium and zinc were systematized. The monotonous change from lanthanum to lutetium was ascertained for activity values and activity coefficients of trivalent lanthanides in the melts, which permits calculating the values for the systems of fusible metals, where no experimental data are available [ru
Nikolaeva, E. A.; Bikmaev, I. F.; Shimansky, V. V.; Sakhibullin, N. A.
2017-06-01
We investigate parameters of two high-mass X-ray binary systems IGR J17544-2619 and IGR J21343+4738 discovered by INTEGRAL space observatory by using optical data of Russian Turkish Telescope (RTT-150). Long-term optical observations of X-ray binary systems IGR J17544-2619 and IGR J21343+4738 were carried out in 2007-2015. Based on the RTT-150 data we estimated orbital periods of these systems. We have modeled the profiles of line HeI 6678 Å in spectra of studied optical stars and obtain the parameters of the star's atmosphere.
Alpha particle spectra in coincidence with normal and superdeformed states in {sup 150}Tb
Energy Technology Data Exchange (ETDEWEB)
Viesti, G.; Lunardon, M.; Bazzacco, D. [dell`Universita, Padova (Italy)]|[INFN, Padova (Italy)] [and others
1996-12-31
The study of correlations between particle evaporation from highly excited compound nuclei at large angular momenta and the states in the final evaporation residues (ER) is a field of investigation which has been opened, in the last years, with the advent of the new large {gamma}-ray arrays. It is now possible to correlate the evaporation spectra to various bands with shapes ranging from spherical to superdeformed (SD) in the same final nucleus. It is generally accepted that the particle evaporation from the compound nucleus is chaotic and that only in the near-yrast {gamma} cascade, where the feeding of different classes of states takes place, the ordered motion is restored. The sensitivity of the particle spectra on the feeding of specific states in the residual nuclei can be taken as an indication that additional degrees of freedom might be important in the evaporation process or that particular regions of the phase space open to the decay populate preferentially some selected structures in the final cold nucleus. This latter point is important for the understanding of the feeding mechanism of SD states. Several experiments performed so far did not find a clear dependence of the shapes of the particle spectra on the excited states having different deformations in the ER. For example, the proton spectra in coincidence with transitions in the SD bands of {sup 133}Nd and {sup 152}Dy nuclei were found to be similar to those in coincidence with transitions in the normal deformed (ND) bands. Alpha particles have been proposed since long as a sensitive probe of the deformation of the emitting nucleus. Results are presented here of an experiment in which the authors have measured the energy spectra of alpha particles associated with different classes of states (ND and SD) in the {sup 150}Tb nucleus populated in the reaction {sup 37}Cl({sup 120}Sn, {alpha}3n{gamma}){sup 150}Tb.
Institute of Scientific and Technical Information of China (English)
潘静; 张清华
2012-01-01
Objective To analyzes prognova compatibility mifepristone and misoprostol on the curative effect of missed abortion. Methods 150 cases of missed abortion patients oral prognova 3 mg three times a day, and at the same time, graded and clothing mifepristone 50 mg a day secondary x3 day, a total of 300 mg, The fourth day meal suit misoprostol 600 ug, after observation abdominal pain, bleeding, organization content discharge and the qing dynasty palace, etc.Results Complete abortion rate 93.07%, incomplete abortion rate 4.6%, not abortion is 2.3%.Conclusion prognova compatibility mifepristone and misoprostol for missed abortion patients safe, effective, convenient.% 目的:探讨补佳乐配伍米非司酮、米索前列醇对稽留流产的疗效.方法:150例稽留流产患者口服补佳乐3 mg 一日三次,同时分次加服米非司酮50 mg 一日二次 x3天,共计300mg,第4天顿服米索前列醇600ug,用药后观察腹痛、出血、组织物排出及清宫等情况.结果:完全流产率93.07%,不全流产率4.6%,未流产者占2.3%.结论:补佳乐配伍米非司酮、米索前列醇对稽留流产患者安全、有效、方便.
Irradiation performance of oxide dispersion strengthened copper alloys to 150 dpa at 415 degree C
International Nuclear Information System (INIS)
Edwards, D.J.; Kumar, A.S.; Anderson, K.R.; Stubbins, J.F.; Garner, F.A.; Hamilton, M.L.
1991-11-01
Results have been obtained on the post-irradiation properties of various oxide dispersion strengthened copper alloys irradiated from 34 to 150 dpa at 415 degrees C in the Fast Flux Test Facility. The GlidCop alloys strengthened by Al 2 O 3 continue to outperform other alloys with respect to swelling resistance, and retention of both electrical conductivity and yield strength. Several castable ODS alloys and a Cr 2 O 3 -strengthened alloy show increasingly poor resistance to radiation, especially in their swelling behavior. A HfO 2 -strengthened alloy retains most of its strength and its electrical conductivity reaches a constant level after 50 dpa, but it exhibits a higher residual radioactivity
Indication for a K/sup π/ = 0- octupole band in 150Nd from electron scattering
International Nuclear Information System (INIS)
Creswell, C.; Hirsch, A.; Bertozzi, W.; Heisenberg, J.; Kowalski, S.; Sargent, C.P.; Turchinetz, W.; Dieperink, A.
1978-01-01
Recent electron scattering results on the 0.850 MeV level of 150 Nd, when analyzed in terms of the interacting boson model, are inconsistent with the interpretation of this level as a pure J/sup π/(K) = 2 + (0) state. Very recent (n,n'γ) work has shown this level to be a 1 - , 2 + doublet. Assuming this level to be the band head of a ''K/sup π/ = 0 - '' octupole band, a simple model is used to predict electron scattering form factors for the 0.850 MeV state and a 3 - octupole level observed at 0.931 MeV. Comparison is made between these predicted form factors and recent electron scattering data
The Orgueil meteorite: 150 years of history
Gounelle, Matthieu; Zolensky, Michael E.
2014-10-01
The goal of this paper is to summarize 150 yr of history of a very special meteorite. The Orgueil meteorite fell near Montauban in southwestern France on May 14, 1864. The bolide, which was the size of the full Moon, was seen across Western France, and almost immediately made the news in local and Parisian newspapers. Within a few weeks of the fall, a great diversity of analyses were performed under the authority of Gabriel Auguste Daubrée, geology professor at the Paris Museum, and published in the Comptes Rendus de l'Académie des Sciences. The skilled scientists reported the presence of iron sulfides, hydrated silicates, and carbonates in Orgueil. They also characterized ammonium salts which are now gone, and observed sulfates being remobilized at the surface of the stone. They identified the high water and carbon contents, and noted similarities with the Alais meteorite, which had fallen in 1806, 300 km away. While Daubrée and his colleagues noted the similarity of the Orgueil organic matter with some terrestrial humus, they were cautious not to make a direct link with living organisms. One century later, Nagy and Claus were less prudent and announced the discovery of "organized" elements in some samples of Orgueil. Their observations were quickly discredited by Edward Anders and others who also discovered that some pollen grains were intentionally placed into the rock back in the 1860s. Orgueil is now one of the most studied meteorites, indeed one of the most studied rocks of any kind. Not only does it contain a large diversity of carbon-rich compounds, which help address the question of organo-synthesis in the early solar system but its chemical composition is also close to that of the Sun's photosphere and serves as a cosmic reference. Secondary minerals, which make up 99% of the volume of Orgueil, were probably formed during hydrothermal alteration on the parent-body within the first few million years of the solar system; their study is essential to our
Energy Technology Data Exchange (ETDEWEB)
Tyrrell, Chris J [Derriford Hospital, Plymouth (United Kingdom); Payne, Heather [Middlesex Hospital, London (United Kingdom); See, William A [Medical College of Wisconsin, Milwaukee, WI (United States); McLeod, David G [Walter Reed Army Medical Center, Washington, DC (United States); Wirth, Manfred P [Department of Urology, Technical University of Dresden (Germany); Iversen, Peter [Department of Urology, Rigshospitalet, Copenhagen (Denmark); Armstrong, Jon [AstraZeneca, Macclesfield (United Kingdom); Morris, Clive [AstraZeneca, Macclesfield (United Kingdom)
2005-07-01
Background and purpose: The ongoing Early Prostate Cancer (EPC) programme is assessing bicalutamide ('Casodex') 150 mg, either alone or as adjuvant to treatment of curative intent, in patients with localised or locally advanced prostate cancer (n=8113). This paper presents an exploratory analysis of the subgroup of the EPC programme who received radiotherapy with curative intent (n=1370) in order to determine the efficacy (in terms of progression-free survival [PFS]) and tolerability of bicalutamide 150 mg in this setting. Patients and methods: 1370 patients with T1-4, M0, any N prostate cancer received bicalutamide 150 mg or placebo adjuvant to radiotherapy of curative intent. This analysis was undertaken at median 5.3 years' follow-up. Results: In patients with locally advanced disease (n=305), bicalutamide adjuvant to radiotherapy significantly increased PFS by 53% (event-time ratio 1.53; 95% confidence intervals [CI] 1.16, 2.02) compared with placebo and reduced the risk of disease progression by 42% (hazard ratio [HR] 0.58; 95% CI 0.41, 0.84; P=0.00348). In these patients, objective progression was experienced by 33.5% of those randomised to bicalutamide versus 48.6% for those randomised to placebo. The between-group difference in patients with localised disease (n=1065) failed to reach statistical significance (HR 0.80; 95% CI 0.62, 1.03; P=0.088). The most common adverse events were breast pain (74.8%) and gynaecomastia (66.6%), which were mild to moderate in >90% of cases. Conclusions: Bicalutamide 150 mg/day given as adjuvant to radiotherapy significantly improved PFS in patients with locally advanced prostate cancer. For patients with localised disease, the results at this stage from the radiotherapy subgroup and the overall EPC programme suggest that adjuvant hormonal therapy is currently not appropriate. There were no unexpected tolerability findings.
International Nuclear Information System (INIS)
Koning, A.J.; Chadwick, M.B.; MacFarlane, R.E.; Mashnik, S.; Wilson, W.B.
1998-05-01
New transmutation-activation nuclear data libraries for neutrons and protons up to 150 MeV have been created. These data are important for simulation calculations of radioactivity, and transmutation, in accelerator-driven systems such as the production of tritium (APT) and the transmutation of waste (ATW). They can also be used to obtain cross section predictions for the production of proton-rich isotopes in (p,xn) reactions, for radioactive ion beam (RIB) target-design studies. The nuclear data in these libraries stem from two sources: for neutrons below 20 MeV, we use data from the European activation and transmutation file, EAF97; For neutrons above 20 MeV and for protons at all energies we have isotope production cross sections with the nuclear model code HMS-ALICE. This code applies the Monte Carlo Hybrid Simulation theory, and the Weisskopf-Ewing theory, to calculate cross sections. In a few cases, the HMS-ALICE results were replaced by those calculated using the GNASH code for the Los Alamos LA150 transport library. The resulting two libraries, AF150.N and AF150.P, consist of 766 nuclides each and are represented in the ENDF6-format. An outline is given of the new representation of the data. The libraries have been checked with ENDF6 preprocessing tools and have been processed with NJOY into libraries for the Los Alamos transmutation/radioactivity code CINDER. Numerous benchmark figures are presented for proton-induced excitation functions of various isotopes compared with measurements. Such comparisons are useful for validation purposes, and for assessing the accuracy of the evaluated data. These evaluated libraries are available on the WWW at: http://t2.lanl.gov/. 21 refs
Muschla, Judith A; Muschla, Erin
2011-01-01
Easy to apply lessons for reteaching difficult algebra concepts Many students have trouble grasping algebra. In this book, bestselling authors Judith, Gary, and Erin Muschla offer help for math teachers who must instruct their students (even those who are struggling) about the complexities of algebra. In simple terms, the authors outline 150 classroom-tested lessons, focused on those concepts often most difficult to understand, in terms that are designed to help all students unravel the mysteries of algebra. Also included are reproducible worksheets that will assist teachers in reviewing and r
Energy Technology Data Exchange (ETDEWEB)
Sapienza, Marcelo Tatit; Willegaignon, Jose; Ono, Carla Rachel; Watanabe, Tomoco; Guimaraes, Maria Ines Calil Cury; Buchpiguel, Carlos Alberto [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina. Servico de Medicina Nuclear; Gutterres, Ricardo Fraga; Marechal, Maria Helena da Hora [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)
2009-07-01
Purpose: To evaluate exposure and dosimetry to family members and environment due to outpatient radioiodine therapy of differentiated thyroid carcinoma. Methods: Twenty patients were treated with 100-150 mCi of iodine-131 on an out-patient basis. Family members dosimetry (n = 27) and potential doses inside the house were measured with thermoluminescent dosimeters. Surface contamination and radioactive wastes were also monitored. Results: Less than 1.0 mSv doses were found in 26 co-habitants and 2.8 mSv in a single case (inferior to the acceptable value of 5.0 mSv/procedure). Potential doses in the houses were inferior to 0.25 mSv, excluding the patients bedroom (mean value = 0.69 mSv). Surface contamination (mean = 4.2 Bq.cm{sup -2}) were below clearance levels. Radioactive wastes generated had a volume of 2.5 liters and a total activity estimated in 90 {mu}Ci, with a calculated exposure close to the background radiation levels. Conclusions: No radiological impact was detected after iodine therapy with 100-150 mCi on an out-patient basis followed by experienced professionals. (author)
Localized Corrosion Susceptibility Of Alloy 22 In Na-K-Cl()NO3 Brines At 110 To 150?C
International Nuclear Information System (INIS)
Lian, T; Felker, S J; Hailey, P D; Staggs, K J; Gdowski, G E
2006-01-01
Electrochemical cyclic potentiodynamic polarization experiments were conducted to assess crevice corrosion of Alloy 22 in de-aerated aqueous solutions of chloride and nitrate salts of potassium and sodium in the temperature range 110-150 C. The tests were run in neutral and slightly acidic aqueous solutions. The Alloy 22 specimens were multiple creviced weld prisms. No evidence of crevice corrosion was observed in the range 125-150 C. In the 120 to 160 C temperature range, the anionic concentration of stable aqueous solutions is dominated by nitrate relative to chloride. At nominally 120 C, the minimum nitrate to chloride ratio is about 4.5, and it increases to about 22 at nominally 155 C. The absence of localized corrosion susceptibility in these solutions is attributed to the known inhibiting effect of the nitrate anion. Aqueous solution chemistry studies indicate that nitrate to chloride ratios of less than 0.5 are possible for temperatures up to nominally 116 C. At 110 C, aqueous solutions can have dissolved chloride well in excess of nitrate. Localized corrosion was observed at nitrate to chloride ratios up to 1.0, the highest ratio tested. The extent of localized corrosion was confined to the crevice region of the samples, and was limited for nitrate to chloride ratios greater than or equal to 0.3
Deformational behaviour of fly-ash based geopolymer concrete at temperatures of up to 150°c
Directory of Open Access Journals (Sweden)
Junaid M Talha
2017-01-01
Full Text Available The use of Geopolymer Concrete (GP*C has been on the rise over the last few decades owing to its lower carbon emissions as compared to Ordinary Portland Cement Concrete (OPC. Recent research has also established the superior thermal properties of GPC and makes it an ideal construction material for specialized application. However, the deformational behaviour of GPC at elevated temperatures has not fully understood. If GPC is to be used as a main stream construction material for specialized applications, the exact deformational behaviour of the material under thermal loading needs to be investigated. This paper looks into the deformational characteristics of GPC (with natural crushed siliceous aggregates when dry heated up to 150°C at near zero loading. The deformations recorded using a clip-on extensometer are used to determine the strains developed in the GPC samples due to thermal loads. Coefficient of thermal expansion (CTE for the tested GPC samples was found and was comparable to OPC concrete at the tested temperatures. Between ambient (20°C and 80°C the CTE for GPC was determined to be between 10.3-10.9x10−6mm/mm/°C which is similar to OPC concretes. CTE for temperatures between 80°C and 150°C was determined to be 9.3-10.0x10−6 mm/mm/°C. First heating cycles resulted in much lower CTE which may be due to the presence of evaporable water in the samples. Like OPC, GPC is a non-homogeneous material and the variation in the materials between samples account for the slight variation in the CTE values determined.
Development of in-core measurements in the reactor KS-150
International Nuclear Information System (INIS)
Rana, S.B.
1977-01-01
Mapping of the neutron flux density distribution and of the neutron fluence distribution in the KS-150 reactor core was carried out using an in-core measuring system. The system allows the in-service monitoring of important operating properties of the reactor core and fuel elements and consists of a mapping fuel element assembly with built-in SPN detectors, of transmission paths and a computer facility. The measurement of the neutron flux, neutron fluence and temperature fields in the reactor core was carried out during the power start-up of the reactor using self-powered DPZ-1 detectors. The obtained data are given and the axial distribution of neutron flux is graphically represented for different values of burnup at the same configuration of regulating rods, as is the axial distribution of neutron fluence for different configurations of the regulating rods during operation, and the in-service neutron fluence distribution. The maximal fuel temperature of 500.2 degC was found at a distance of 291.2 cm from the upper boundary of the reactor core, at a neutron flux of 1.46x10 14 n/cm 2 s. In comparison with other methods, this method proved easy and quick, the results reliable, reactivity perturbance negligible and the fuel element cost increase a negligible 4%. Neutron flux mapping using in-core self-powered detectors will be performed on a wider scale. (J.P./J.O.)
Fabrication and Analysis of 150 mm Aperture Nb$_{3}$Sn LARP MQXF Coils
Holik, E F; Anerella, M; Bossert, R; Cavanna, E; Cheng, D; Dietderich, D R; Ferracin, P; Ghosh, A K; Izquierdo Bermudez, S; Krave, S; Nobrega, A; Perez, J C; Pong, I; Rochepault; Sabbi, G L; Schmalzle, J; Yu, M
2016-01-01
The US LHC Accelerator Research Program (LARP) and CERN are combining efforts for the HiLumi-LHC upgrade to design and fabricate 150 mm aperture, interaction region quadrupoles with a nominal gradient of 130 T/m using Nb$_{3}$Sn. To successfully produce the necessary long MQXF triplets, the HiLumi-LHC collaboration is systematically reducing risk and design modification by heavily relying upon the experience gained from the successful 120 mm aperture LARP HQ program. First generation MQXF short (MQXFS) coils were predominately a scaling up of the HQ quadrupole design allowing comparable cable expansion during Nb$_{3}$Sn formation heat treatment and increased insulation fraction for electrical robustness. A total of 13 first generation MQXFS coils were fabricated between LARP and CERN. Systematic differences in coil size, coil alignment symmetry, and coil length contraction during heat treatment are observed and likely due to slight variances in tooling and insulation/cable systems. Analysis of coil cross sect...
150 years of the New York Academy of Medicine: a series of exhibitions.
Black, L F; North, M J
1996-01-01
As the New York Academy of Medicine celebrates its 150th year as a leader in the field of urban health, it is instructive to review the events and decisions that influenced and shaped it. Since its inception, the Academy has taken an active role in lobbying state and local governments to enact more-effective public health laws and in educating the public about improving health conditions. During 1996 and 1997, the Academy Library's Historical Collections is mounting a series of six exhibitions that are intended to tell the story of public health in New York as influenced by the New York Academy of Medicine. The story will be told using printed books, pamphlets, posters, photographs, and manuscripts drawn from the Library's collections, as well as the Academy's archives. Each exhibition will highlight the Academy's accomplishments in the subject areas presented. In this article, we summarize all six of the exhibitions and offer an in-depth look at the first two exhibitions.
Ellwood, Michael J.; Bowie, Andrew R.; Baker, Alex; Gault-Ringold, Melanie; Hassler, Christel; Law, Cliff S.; Maher, William A.; Marriner, Andrew; Nodder, Scott; Sander, Sylvia; Stevens, Craig; Townsend, Ashley; van der Merwe, Pier; Woodward, E. Malcolm S.; Wuttig, Kathrin; Boyd, Philip W.
2018-02-01
Iron, phosphate, and nitrate are essential nutrients for phytoplankton growth, and hence, their supply into the surface ocean controls oceanic primary production. Here we present a GEOTRACES zonal section (GP13; 30-33°S, 153°E-150°W) extending eastward from Australia to the oligotrophic South Pacific Ocean gyre outlining the concentrations of these key nutrients. Surface dissolved iron concentrations are elevated at >0.4 nmol L-1 near continental Australia (west of 165°E) and decreased eastward to ≤0.2 nmol L-1 (170°W-150°W). The supply of dissolved iron into the upper ocean (nitrate concentrations averaged 5 ± 4 nmol L-1 between 170°W and 150°W, while surface water phosphate concentrations averaged 58 ± 30 nmol L-1. The supply of nitrogen into the upper ocean is primarily from deeper waters (24-1647 μmol m-2 d-1) with atmospheric deposition and nitrogen fixation contributing leading to almost quantitative removal of nitrate. The supply stoichiometry for iron and nitrogen relative to phosphate at and above the DCM declines eastward leading to two biogeographical provinces: one with diazotroph production and the other without diazotroph production.
Di Stefano, Giuseppe
2016-01-01
Reseña de Emilio Pasquini, ed., Studi e problemi di critica testuale: 1960-2010. Per i 150 anni della Commissione per i testi di lingua, Commissione per i testi di lingua (Collezione di opere inedite o rare, 169), Bologna, 2012, x + 320 pp. ISBN: 9788898096152.
First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC
Ambrosio, G; Wanderer, P; Ferracin, P; Sabbi, G
2017-01-01
The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb$_{3}$Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.
First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC
Energy Technology Data Exchange (ETDEWEB)
Ambrosio, G. [Fermilab; Chlachidze, G. [Fermilab; Wanderer, P. [Brookhaven; Ferracin, P. [CERN; Sabbi, G. [LBNL, Berkeley
2016-10-06
The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.
Wang, Xinyu; Ren, Yanli; Wang, Zhiqiong; Xiong, Xiangyu; Han, Sichong; Pan, Wenting; Chen, Hongwei; Zhou, Liqing; Zhou, Changchun; Yuan, Qipeng; Yang, Ming
2015-12-21
5S rRNA plays an important part in ribosome biology and is over-expression in multiple cancers. In this study, we found that 5S rRNA is a direct target of miR-150 and miR-383 in esophageal squamous cell carcinoma (ESCC). Overexpression of miR-150 and miR-383 inhibited ESCC cell proliferation in vitro and in vivo. Moreover, 5S rRNA silencing by miR-150 and miR-383 might intensify rpL11-c-Myc interaction, which attenuated role of c-Myc as an oncogenic transcriptional factor and dysregulation of multiple c-Myc target genes. Taken together, our results highlight the involvement of miRNAs in ribosomal regulation during tumorigenesis. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Tornack, Julia; Kawano, Yohei; Garbi, Natalio; Hämmerling, Günter J; Melchers, Fritz; Tsuneto, Motokazu
2017-09-01
The pool of hematopoietic stem cells (HSCs) in the bone marrow is a mixture of resting, proliferating, and differentiating cells. Long-term repopulating HSCs (LT-HSC) are routinely enriched as Lin - Sca1 + c-Kit + CD34 - Flt3 - CD150 + CD48 - cells. The Flt3 ligand (Flt3L) and its receptor Flt3 are important regulators of HSC maintenance, expansion and differentiation. Using Flt3L-eGFP reporter mice, we show that endogenous Flt3L-eGFP-reporter RNA expression correlates with eGFP-protein expression. This Flt3L-eGFP-reporter expression distinguishes two LT-HSC populations with differences in gene expressions and reconstituting potential. Thus, Flt3L-eGFP-reporter low cells are identified as predominantly resting HSCs with long-term repopulating capacities. In contrast, Flt3L-eGFP-reporter high cells are in majority proliferating HSCs with only short-term repopulating capacities. Flt3L-eGFP-reporter low cells express hypoxia, autophagy-inducing, and the LT-HSC-associated genes HoxB5 and Fgd5, while Flt3L-eGFP-reporter high HSCs upregulate genes involved in HSC differentiation. Flt3L-eGFP-reporter low cells develop to Flt3L-eGFP-reporter high cells in vitro, although Flt3L-eGFP-reporter high cells remain Flt3L-eGFP-reporter high . CD150 + Flt3L-eGFP-reporter low cells express either endothelial protein C receptor (EPCR) or CD41, while Flt3L-eGFP-reporter high cells do express EPCR but not CD41. Thus, FACS-enrichment of Flt3/ Flt3L-eGFP-reporter negative, Lin - CD150 + CD48 - EPCR + CD41 + HSCs allows a further 5-fold enrichment of functional LT-HSCs. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
DEFF Research Database (Denmark)
Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent
2017-01-01
Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...... or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high...
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
DEFF Research Database (Denmark)
Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent
2017-01-01
Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome...... or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...
1981-06-01
The process development continued, with a total of nine crystal growth runs. One of these was a 150 kg run of 5 crystals of approximately 30 kg each. Several machine and process problems were corrected and the 150 kg run was as successful as previous long runs on CG2000 RC's. The accelerated recharge and growth will be attempted when the development program resumes at full capacity in FY '82. The automation controls (Automatic Grower Light Computer System) were integrated to the seed dip temperature, shoulder, and diameter sensors on the CG2000 RC development grower. Test growths included four crystals, which were grown by the computer/sensor system from seed dip through tail off. This system will be integrated on the Mod CG2000 grower during the next quarter. The analytical task included the completion and preliminary testing of the gas chromatograph portion of the Furnace Atmosphere Analysis System. The system can detect CO concentrations and will be expanded to oxygen and water analysis in FY '82.
1981-01-01
The goals in this program for advanced czochralski growth process to produce low cost 150 kg silicon ingots from a single crucible for technology readiness are outlined. To provide a modified CG2000 crystal power capable of pulling a minimum of five crystals, each of approximately 30 kg in weight, 150 mm diameter from a single crucible with periodic melt replenishment. Crystals to have: resistivity of 1 to 3 ohm cm, p-type; dislocation density below 1- to the 6th power per cm; orientation (100); after growth yield of greater than 90%. Growth throughput of greater than 2.5 kg per hour of machine operation using a radiation shield. Prototype equipment suitable for use as a production facility. The overall cost goal is $.70 per peak watt by 1986. To accomplish these goals, the modified CG2000 grower and development program includes: (1) increased automation with a microprocessor based control system; (2) sensors development which will increase the capability of the automatic controls system, and provide technology transfer of the developed systems.
Railgun accelerators for launching 0.1-g payloads at velocities greater than 150 km/s
International Nuclear Information System (INIS)
Hawke, R.S.
1979-01-01
The promise of an abundant energy supply has inspired many approaches to controlling thermal nuclear fusion. One approach to initiating fusion is to use a hypervelocity projectile to impact a deuterium--tritium (DT) pellet. For this purpose, magnetic accelerators have been propsed for accelerating macroparticles to velocities greater than 100 km/s. This paper summarizes a portion of a study that assesses the feasibility of accelerating a 0.1-g payload to a velocity of 150 km/s or more. In that study it was concluded that magnetic-gradient and railgun accelerators could achieve the goal. The critical factors that limit the design and operation of railgun accelerators are discussed. These factors are combined with a simulation code to assess potential railgun performance in this regime
International Nuclear Information System (INIS)
Cortez, B.; LoSecco, J.; Sulak, L.; Soukas, A.; Weng, W.
1981-01-01
We report on a sensitive search for neutrino oscillation. A pure nu/sub μ/ beam of low energy was constructed at the Brookhaven AGS. The appearance of any nu/sub e/ in the beam would signify oscillations. To maximize sensitivity the energy of the neutrino beam was reduced to 150 MeV. The existing neutrino beam line and a 30T liquid scintillation calorimeter used in previous nu p scattering experiments were utilized
The 150 ns detector project: progress with small detectors
International Nuclear Information System (INIS)
Warburton, W.K.; Russell, S.R.; Kleinfelder, Stuart A.; Segal, Julie
1994-01-01
This project's long term goal is to develop a pixel area detector capable of 6 MHz frame rates (150 ns/frame). Our milestones toward this goal are: a single pixel, 1x256 1D and 8x8 2D detectors, 256x256 2D detectors and, finally, 1024x1024 2D detectors. The design strategy is to supply a complete electronics chain (resetting preamp, selectable gain amplifier, analog-to-digital converter (ADC), and memory) for each pixel. In the final detectors these will all be custom integrated circuits. The front end preamplifiers are being integrated first, since their design and performance are both the most unusual and also critical to the project's success. Similarly, our early work is also concentrating on devising and perfecting detector structures which are thick enough (1 mm) to absorb over 99% of the incident X-rays in the energy range of interest. In this paper we discuss our progress toward the 1x256 1D and 8x8 2D detectors. We have fabricated sample detectors at Stanford's Center for Integrated Systems and are preparing both to test them individually and to wirebond them to the preamplifier samples to produce our first working small 1D and 2D detectors. We will describe our solutions to the design problems associated with collecting charge in less than 30 ns from 1 mm thick pixels in high resistivity silicon. We have constructed and tested the front end of our preamplifier design using a commercial 1.2 μm CMOS technology and are moving on to produce a few channels of the complete preamplifier, including a switchable gain stage and output stage. We will discuss both the preamplifier design and our initial test results. ((orig.))
[Anaerobic bacteria 150 years after their discovery by Pasteur].
García-Sánchez, José Elías; García-Sánchez, Enrique; Martín-Del-Rey, Ángel; García-Merino, Enrique
2015-02-01
In 2011 we celebrated the 150th anniversary of the discovery of anaerobic bacteria by Louis Pasteur. The interest of the biomedical community on such bacteria is still maintained, and is particularly focused on Clostridium difficile. In the past few years important advances in taxonomy have been made due to the genetic, technological and computing developments. Thus, a significant number of new species related to human infections have been characterised, and some already known have been reclassified. At pathogenic level some specimens of anaerobic microflora, that had not been isolated from human infections, have been now isolated in some clinical conditions. There was emergence (or re-emergence) of some species and clinical conditions. Certain anaerobic bacteria have been associated with established infectious syndromes. The virulence of certain strains has increased, and some hypotheses on their participation in certain diseases have been given. In terms of diagnosis, the routine use of MALDI-TOF has led to a shortening of time and a cost reduction in the identification, with an improvement directly related to the improvement of data bases. The application of real-time PCR has been another major progress, and the sequencing of 16srRNA gene and others is currently a reality for several laboratories. Anaerobes have increased their resistance to antimicrobial agents, and the emergence of resistance to carbapenems and metronidazole, and multi-resistance is a current reality. In this situation, linezolid could be an effective alternative for Bacteroides. Fidaxomicin is the only anti-anaerobic agent introduced in the recent years, specifically for the diarrhoea caused by C.difficile. Moreover, some mathematical models have also been proposed in relation with this species. Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
The 150 ns detector project: progress with small detectors
Energy Technology Data Exchange (ETDEWEB)
Warburton, W.K. (X-ray Instrumentation Associates, 2513 Charleston Rd, Ste 207, Mountain View, CA 94043 (United States)); Russell, S.R. (X-ray Instrumentation Associates, 2513 Charleston Rd, Ste 207, Mountain View, CA 94043 (United States)); Kleinfelder, Stuart A. (VLSI Physics, 19 Drury Lane, Berkeley, CA 94705 (United States)); Segal, Julie (Integrated Ckts Lab., Dept. of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States))
1994-09-01
This project's long term goal is to develop a pixel area detector capable of 6 MHz frame rates (150 ns/frame). Our milestones toward this goal are: a single pixel, 1x256 1D and 8x8 2D detectors, 256x256 2D detectors and, finally, 1024x1024 2D detectors. The design strategy is to supply a complete electronics chain (resetting preamp, selectable gain amplifier, analog-to-digital converter (ADC), and memory) for each pixel. In the final detectors these will all be custom integrated circuits. The front end preamplifiers are being integrated first, since their design and performance are both the most unusual and also critical to the project's success. Similarly, our early work is also concentrating on devising and perfecting detector structures which are thick enough (1 mm) to absorb over 99% of the incident X-rays in the energy range of interest. In this paper we discuss our progress toward the 1x256 1D and 8x8 2D detectors. We have fabricated sample detectors at Stanford's Center for Integrated Systems and are preparing both to test them individually and to wirebond them to the preamplifier samples to produce our first working small 1D and 2D detectors. We will describe our solutions to the design problems associated with collecting charge in less than 30 ns from 1 mm thick pixels in high resistivity silicon. We have constructed and tested the front end of our preamplifier design using a commercial 1.2 [mu]m CMOS technology and are moving on to produce a few channels of the complete preamplifier, including a switchable gain stage and output stage. We will discuss both the preamplifier design and our initial test results. ((orig.))
Oxidation of UO2 at 150 to 3500C
International Nuclear Information System (INIS)
Gilbert, E.R.; White, G.D.; Knox, C.A.
1985-02-01
Tests were performed on nonirradiated UO 2 pellets from 150 to 350 0 C in atmospheric air and controlled environments and on spent light-water reactor (LWR) fuel fragments at 200 and 230 0 C in atmospheric air to determine the variables that affect oxidation behavior under dry storage conditions. The weight of spent fragments increased 50 to 100 times faster than the weight of nonirradiated UO 2 pellets at 230 0 C. Non-irradiated pellet fragments gained weight 5 to 7 times faster than nonirradiated pellets. The fragments simulated fuel fragmented by thermal gradients during reactor power changes. Low-density powder (U 3 O 8 ) formed at 0.05 and 0.3% weight gain for nonirradiated pellets and fragments, respectively, but had not formed at 3% weight gain for spent fuel fragments with a burnup of 29,000 MWd/MTU. Canadian investigators had found that powder formed at intermediate levels of weight gain in CANDU spent fuel fragments with an approximate burnup of 8000 MWd/MTU. The combined effects of the high rate of weight gain in spent fuel and the burnup dependence of weight gain at powder formation resulted in a minimum in a plot of the time for the onset of powder formation versus burnup. The minimum in powder induction time occurs at or below burnup levels typical of CANDU spent fuel and spent fuel at the ends of some LWR rods. The results are described in terms of thermal and neutron irradiation-induced changes in UO 2 pellet structure and chemical composition. Other tests were performed at up to 275 0 C with spent fuel fragments and nonirradiated UO 2 pellets in moist nitrogen to determine the suitability of nitrogen as a cover gas. No measurable weight gain or visible physical changes occurred during the first 2 months of testing. 22 figures, 7 tables
Czech Academy of Sciences Publication Activity Database
Buryi, Maksym; Laguta, Valentyn; Rosa, Jan; Nikl, Martin
2016-01-01
Roč. 90, Jul (2016), s. 23-26 ISSN 1350-4487 R&D Projects: GA ČR GAP204/12/0805; GA MŠk(CZ) LM2011029; GA MŠk LO1409 Institutional support: RVO:68378271 Keywords : electron paramagnetic resonance * scintillators * lutetium oxyorthosilicate * exchange coupled ions * cerium ions Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.442, year: 2016
International Nuclear Information System (INIS)
Rabatin, J.G.
1984-01-01
Oxyhalides of lanthanum, gadolinium and lutetium coactivated with a first activator selected from bismuth and samarium to provide the color of light emission and a second coactivator (e.g. terbium or praseodymium) which increases the amount of stored energy in a stored radiographic latent image are found to be superior in their conversion efficiency of x-rays to visible light. (author)
Assignment of 4f-5d absorption bands in Ce-doped RAlO.sub.3./sub. (R=La, Gd, Y, Lu) perovskites
Czech Academy of Sciences Publication Activity Database
Mihóková, Eva; Nikl, Martin; Bacci, M.; Dušek, Michal; Petříček, Václav
2009-01-01
Roč. 79, č. 19 (2009), 1951309/1-1951309/7 ISSN 1098-0121 R&D Projects: GA MŠk ME 903; GA AV ČR IAA100100810 Institutional research plan: CEZ:AV0Z10100521 Keywords : cerium * EHT calculations * gadolinium compounds * lanthanum compounds * lutetium compounds * ultraviolet spectra * yttrium compounds Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.475, year: 2009
Czech Academy of Sciences Publication Activity Database
Pejchal, Jan; Fujimoto, Y.; Chani, V.; Yanagida, T.; Yokota, Y.; Yoshikawa, A.; Nikl, Martin; Beitlerová, Alena
2012-01-01
Roč. 360, SI (2012), 127–130 ISSN 0022-0248 R&D Projects: GA MŠk(CZ) 1M06002 Grant - others:AVČR(CZ) M100100910 Institutional research plan: CEZ:AV0Z10100521 Keywords : Ti-doping * micro-pulling-down * barium lutetium fluoride * lithium aluminate * neutron scintillator Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.552, year: 2012
DEFF Research Database (Denmark)
Bak, Claus Leth; Sigurbjörnsson, Ragnar; Bukh, Bjarne
2016-01-01
are interconnected in a simple way but via transformers and infeed from remaining parts of the network. Distance relay measured fault loop impedance shows wide ranges of variations for both phase-phase loops as well as phase-earth loops. No simple relations exist. Simulation models can be used to study fault loop...... impedance for combined faults and thereby shed light on relay trips. This study uses actual fault records, analytical method and PSCAD simulation studies to analyse combined faults in an existing 400 and 150 kV transmission line owned by Danish TSO Energinet.dk. The results clearly show that an accurate...
Directory of Open Access Journals (Sweden)
Giuseppe Di Stefano
2016-01-01
Full Text Available Reseña de Emilio Pasquini, ed., Studi e problemi di critica testuale: 1960-2010. Per i 150 anni della Commissione per i testi di lingua, Commissione per i testi di lingua (Collezione di opere inedite o rare, 169, Bologna, 2012, x + 320 pp. ISBN: 9788898096152.
Test of Bjorken scaling in deep inelastic muon scattering at 150 and 56.3 GeV
International Nuclear Information System (INIS)
Watanabe, Y.
1975-01-01
A test of Bjorken scaling has been made at Fermilab in deep inelastic muon scattering by comparing two sets of data taken at 150 and 56 GeV. The muon beam was obtained from the decay of pions and kaons produced by letting the 300 GeV extracted proton beam strike the production target. The incident muon beam was detected by proportional chambers and the scattered muons from the iron target were reconstructed from a spectrometer consisting of wire spark chambers, scintillation counters and toroidal iron magnets. The apparatus had a large aperture and an azimuthally symmetric acceptance. It was designed so that the events with the same values of scaling variables, e.g., x = Q 2 /2Mν and y = ν/E 0 , go through the same region of the detectors at the two energies. Most of the systematic uncertainties cancel in comparing the two sets of data, thus increasing the sensitivity to the scaling behavior. The kinematic range investigated is Q 2 up to 40 (GeV/c) 2 and ν up to 100 GeV. The Q 2 dependence of the ratio of 150 and 56 GeV data was corrected by Monte Carlo calculations to take out remaining nonscaling contributions. A possible breakdown of scaling was expressed in the propagator form, νW 2 (x,Q 2 ) = νW 2 (x). N/(1 + Q 2 /Λ 2 ) 2 . By constraining N to 1 +- 0.05, Λ -2 = (27 +- 36) . 10 -4 (GeV/c 2 ) -2 (9.3 percent confidence) was obtained and a lower limit to Λ was obtained to be 10 GeV/c 2 in 95 percent confidence. Thus the result presented here is consistent with the scaling prediction. It is emphasized however, that the result is based on subsets of data analyzed assuming a particular form of breakdown
Co-firing straw and coal in a 150-MWe utility boiler: in situ measurements
DEFF Research Database (Denmark)
Hansen, P. F.B.; Andersen, Karin Hedebo; Wieck-Hansen, K.
1998-01-01
A 2-year demonstration program is carried out by the Danish utility I/S Midtkraft at a 150-MWe PF-boiler unit reconstructed for co-firing straw and coal. As a part of the demonstration program, a comprehensive in situ measurement campaign was conducted during the spring of 1996 in collaboration...... with the Technical University of Denmark. Six sample positions have been established between the upper part of the furnace and the economizer. The campaign included in situ sampling of deposits on water/air-cooled probes, sampling of fly ash, flue gas and gas phase alkali metal compounds, and aerosols as well...... deposition propensities and high temperature corrosion during co-combustion of straw and coal in PF-boilers. Danish full scale results from co-firing straw and coal, the test facility and test program, and the potential theoretical support from the Technical University of Denmark are presented in this paper...
International Nuclear Information System (INIS)
Bray, Igor; Konovalov, D.A.; McCarthy, I.E.
1991-04-01
A coupled-channel optical method for electron-atom scattering is applied to elastic electron-sodium scattering at energies of 20, 22.1, 54.4, 100, and 150 eV. It is demonstrated that the effect of all the inelastic channels on elastic scattering may be well reproduced by the 'ab initio' calculated complex non-local polarization potential. Whilst the experiments generally agree at small angles and therefore agree on the total elastic cross section, there is considerable discrepancy at intermediate and backward angles. 9 refs., 2 tabs., 1 fig
Electroluminescence from a single InGaN quantum dot in the green spectral region up to 150 K
International Nuclear Information System (INIS)
Kalden, J; Sebald, K; Gutowski, J; Tessarek, C; Figge, S; Kruse, C; Hommel, D
2010-01-01
We present electrically driven luminescence from single InGaN quantum dots embedded into a light emitting diode structure grown by metal-organic vapor-phase epitaxy. Single sharp emission lines in the green spectral region can be identified. Temperature dependent measurements demonstrate thermal stability of the emission of a single quantum dot up to 150 K. These results are an important step towards applications like electrically driven single-photon emitters, which are a basis for applications incorporating plastic optical fibers as well as for modern concepts of free space quantum cryptography.
Radiation hard pixel sensors using high-resistive wafers in a 150 nm CMOS processing line
Pohl, D.-L.; Hemperek, T.; Caicedo, I.; Gonella, L.; Hügging, F.; Janssen, J.; Krüger, H.; Macchiolo, A.; Owtscharenko, N.; Vigani, L.; Wermes, N.
2017-06-01
Pixel sensors using 8'' CMOS processing technology have been designed and characterized offering the benefits of industrial sensor fabrication, including large wafers, high throughput and yield, as well as low cost. The pixel sensors are produced using a 150 nm CMOS technology offered by LFoundry in Avezzano. The technology provides multiple metal and polysilicon layers, as well as metal-insulator-metal capacitors that can be employed for AC-coupling and redistribution layers. Several prototypes were fabricated and are characterized with minimum ionizing particles before and after irradiation to fluences up to 1.1 × 1015 neq cm-2. The CMOS-fabricated sensors perform equally well as standard pixel sensors in terms of noise and hit detection efficiency. AC-coupled sensors even reach 100% hit efficiency in a 3.2 GeV electron beam before irradiation.