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Sample records for lpa-i lpa-i a-ii

  1. Elevated Lipoprotein(a) Levels, LPA> Risk Genotypes, and Increased Risk of Heart Failure in the General Population

    DEFF Research Database (Denmark)

    Kamstrup, Pia R; Nordestgaard, Børge G

    2016-01-01

    OBJECTIVES: This study sough to test whether elevated lipoprotein(a) levels and corresponding LPA risk genotypes (low number of kringle IV type 2 repeats, rs3798220 and rs10455872, minor allele carriers) are associated with an increased risk of heart failure (HF). BACKGROUND: Elevated lipoprotein...

  2. Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures

    International Nuclear Information System (INIS)

    Chang, Y.F.; Hargest, V.; Chen, J.S.

    1988-01-01

    L-lysine and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice. L-Lysine of L-Pa i.p. significantly increased clonic and tonic latencies in a dose-dependent manner against 90 mg/kg PTZ-induced seizures. L-Lysine but not L-Pa enhanced the anticonvulsant effect of diazepam (DZ). L-Pa i.c.v. showed a slight decrease in clonic latency; it did not enhance the antiseizure activity of DZ; it caused seizures at 0.6 mmol/kg. D-PA i.c.v. displayed an opposite effect compared to its L-isomer. The anticonvulsant effect of L-lysine in terms of increase in seizure latency and survival was even more amplified when tested with a submaximal PTZ concentration. L-Lysine showed an enhancement of specific 3 H-flunitrazepam(FZ) binding to mouse brain membranes both in vitro an din vivo. The possibility of L-lysine acting as a modulator for the GABA/benzodiazepine receptors was demonstrated. Since L-PA showed enhancement of 3 H-FZ binding only in vitro but not in vivo, the anticonvulsant effect of L-PA may not be linked to the GABA/benzodiazepine receptor

  3. Bioinformatic Analysis of Plasma Apolipoproteins A-I and A-II Revealed Unique Features of A-I/A-II HDL Particles in Human Plasma

    Science.gov (United States)

    Kido, Toshimi; Kurata, Hideaki; Kondo, Kazuo; Itakura, Hiroshige; Okazaki, Mitsuyo; Urata, Takeyoshi; Yokoyama, Shinji

    2016-01-01

    Plasma concentration of apoA-I, apoA-II and apoA-II-unassociated apoA-I was analyzed in 314 Japanese subjects (177 males and 137 females), including one (male) homozygote and 37 (20 males and 17 females) heterozygotes of genetic CETP deficiency. ApoA-I unassociated with apoA-II markedly and linearly increased with HDL-cholesterol, while apoA-II increased only very slightly and the ratio of apoA-II-associated apoA-I to apoA-II stayed constant at 2 in molar ratio throughout the increase of HDL-cholesterol, among the wild type and heterozygous CETP deficiency. Thus, overall HDL concentration almost exclusively depends on HDL with apoA-I without apoA-II (LpAI) while concentration of HDL containing apoA-I and apoA-II (LpAI:AII) is constant having a fixed molar ratio of 2 : 1 regardless of total HDL and apoA-I concentration. Distribution of apoA-I between LpAI and LpAI:AII is consistent with a model of statistical partitioning regardless of sex and CETP genotype. The analysis also indicated that LpA-I accommodates on average 4 apoA-I molecules and has a clearance rate indistinguishable from LpAI:AII. Independent evidence indicated LpAI:A-II has a diameter 20% smaller than LpAI, consistent with a model having two apoA-I and one apoA-II. The functional contribution of these particles is to be investigated. PMID:27526664

  4. Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II)

    DEFF Research Database (Denmark)

    Lebars, Isabelle; Husson, Clotilde; Yoshizawa, Satoko

    2007-01-01

    The methyltransferase RlmA(II) (formerly TlrB) is found in many Gram-positive bacteria, and methylates the N-1 position of nucleotide G748 within the loop of hairpin 35 in 23S rRNA. Methylation of the rRNA by RlmA(II) confers resistance to tylosin and other mycinosylated 16-membered ring macrolide......RNA substrate indicated that multiple contacts occur between RlmA(II) and nucleotides in stem-loops 33, 34 and 35. RlmA(II) appears to recognize its rRNA target through specific surface shape complementarity at the junction formed by these three helices. This means of recognition is highly similar...

  5. Atypical Porcine Pestivirus: A Possible Cause of Congenital Tremor Type A-II in Newborn Piglets

    NARCIS (Netherlands)

    de Groof, Ad; Deijs, Martin; Guelen, Lars; van Grinsven, Lotte; van Os-Galdos, Laura; Vogels, Wannes; Derks, Carmen; Cruijsen, Toine; Geurts, Victor; Vrijenhoek, Mieke; Suijskens, Janneke; van Doorn, Peter; van Leengoed, Leo; Schrier, Carla; van der Hoek, Lia

    2016-01-01

    Congenital tremor type A-II in piglets has been regarded as a transmissible disease since the 1970s, possibly caused by a very recently-described virus: atypical porcine pestivirus (APPV). Here, we describe several strains of APPV in piglets with clinical signs of congenital tremor (10 of 10 farms

  6. Concentration quenching of F{sub a}(II) emission in KCl:Li

    Energy Technology Data Exchange (ETDEWEB)

    Baldacchini, G.; Giovenale, E. [ENEA, Centro Ricerche Frascati, Rome (Italy). Dip. Innovazione; Grassano, U.M. [Rome Univ. `Tor Vergata` (Italy); Scacco, A. [Rome Univ. `La Sapienza` (Italy)

    1996-12-01

    The concentration quenching of luminescence is a well known phenomenon for the F centers in alkali halides. On the contrary very little is known on this subject for F{sub A} centers which are a class of axial color centers still of some importance both in basic and applied research, for instance as color center laser sources. The authors have studied carefully the optical properties of the F{sub A}(II) centers, especially in KCl:Li in extreme physical conditions, such as high F{sub A} concentration, high optical pumping, low temperatures and high magnetic fields, and, among other results, a new weak luminescence has been found at 1.4 {mu}m. At moment is not yet clear whether this emission is related to the concentration quenching itself or to more complex color centers, among them F{sub A}(I) centers. However, general hypothesis and reliable measurements are proposed in order to clarify the still unknown microscopic mechanisms which reduces the emission intensity of the F{sub A}(II) centers when they are highly concentrated.

  7. Atypical Porcine Pestivirus: A Possible Cause of Congenital Tremor Type A-II in Newborn Piglets.

    Science.gov (United States)

    de Groof, Ad; Deijs, Martin; Guelen, Lars; van Grinsven, Lotte; van Os-Galdos, Laura; Vogels, Wannes; Derks, Carmen; Cruijsen, Toine; Geurts, Victor; Vrijenhoek, Mieke; Suijskens, Janneke; van Doorn, Peter; van Leengoed, Leo; Schrier, Carla; van der Hoek, Lia

    2016-10-04

    Congenital tremor type A-II in piglets has been regarded as a transmissible disease since the 1970s, possibly caused by a very recently-described virus: atypical porcine pestivirus (APPV). Here, we describe several strains of APPV in piglets with clinical signs of congenital tremor (10 of 10 farms tested). Piglets on a farm with no history of congenital tremor were PCR-negative for the virus. To demonstrate a causal relationship between APPV and disease, three gilts were inoculated via intramuscular injection at day 32 of pregnancy. In two of the three litters, vertical transmission of the virus occurred. Clinical signs of congenital tremor were observed in APPV-infected newborns, yet also two asymptomatic carriers were among the offspring. Piglets of one litter were PCR-negative for the virus, and these piglets were all without congenital tremors. Long-term follow up of farm piglets born with congenital tremors showed that the initially high viremia in serum declines at five months of age, but shedding of the virus in feces continues, which explains why the virus remains present at affected farms and causes new outbreaks. We conclude that trans-placental transmission of APPV and subsequent infection of the fetuses is a very likely cause of congenital tremor type A-II in piglets.

  8. 30 CFR 57.22208 - Auxiliary fans (I-A, II-A, III, and V-A mines).

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Auxiliary fans (I-A, II-A, III, and V-A mines... fans (I-A, II-A, III, and V-A mines). (a) Auxiliary fans, except fans used in shops and other areas... applicable requirements of 30 CFR part 18, and be operated so that recirculation is minimized. Auxiliary fans...

  9. 33 CFR 89.25 - Waters upon which Inland Rules 9(a)(ii), 14(d), and 15(b) apply.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Waters upon which Inland Rules 9(a)(ii), 14(d), and 15(b) apply. 89.25 Section 89.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES INLAND NAVIGATION RULES: IMPLEMENTING RULES Waters...

  10. Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity

    Science.gov (United States)

    Smith, CE; Ordovás, JM; Sánchez-Moreno, C; Lee, Y-C; Garaulet, M

    2011-01-01

    Background The interaction between apolipoprotein A-II (APOA2) m265 genotype and saturated fat for obesity traits has been more extensively demonstrated than for any other locus, but behavioural and hormonal mechanisms underlying this relationship are unexplored. In this study, we evaluated relationships between APOA2 and obesity risk with particular focus on patterns of eating and ghrelin, a hormonal regulator of food intake. Design Cross-sectional study. Subjects Overweight and obese subjects (n = 1225) were evaluated at baseline in five weight loss clinics in southeastern Spain. Methods Behavioural data were assessed using a checklist of weight loss obstacles. Logistic regression models were fitted to estimate the risk of a specific behaviour associated with APOA2 genotype. Relationships between APOA2 genotype and saturated fat intakes for anthropometric traits and plasma ghrelin were evaluated by analysis of variance. To construct categorical variables to evaluate interactions, saturated fat intake was dichotomized into high and low according to the population median intake or as tertiles. Results Homozygous minor (CC) subjects were more likely to exhibit behaviours that impede weight loss (‘Do you skip meals’, odds ratio (OR) = 2.09, P=0.008) and less likely to exhibit the protective behaviour of ‘Do you plan meals in advance’ (OR = 0.64, P=0.034). Plasma ghrelin for CC subjects consuming low saturated fat was lower compared with (1) CC subjects consuming high saturated fat, (2) TT + TC carriers consuming low saturated fat and (3) TT+TC carriers consuming high saturated fat (all Pghrelin. Expansion of knowledge of APOA2 and obesity to include modulation of specific behaviours and hormonal mediators not only broadens understanding of gene–diet interactions, but also facilitates the pragmatic, future goal of developing dietary guidelines based on genotype. PMID:21386805

  11. ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator.

    Science.gov (United States)

    Kido, Toshimi; Kondo, Kazuo; Kurata, Hideaki; Fujiwara, Yoko; Urata, Takeyoshi; Itakura, Hiroshige; Yokoyama, Shinji

    2017-11-29

    We recently reported distinct nature of high-density lipoproteins (HDL) subgroup particles with apolipoprotein (apo) A-I but not apoA-II (LpAI) and HDL having both (LpAI:AII) based on the data from 314 Japanese. While plasma HDL level almost exclusively depends on concentration of LpAI having 3 to 4 apoA-I molecules, LpAI:AII appeared with almost constant concentration regardless of plasma HDL levels having stable structure with two apoA-I and one disulfide-dimeric apoA-II molecules (Sci. Rep. 6; 31,532, 2016). The aim of this study is further characterization of LpAI:AII with respect to its role in atherogenesis. Association of LpAI, LpAI:AII and other HDL parameters with apoB-lipoprotein parameters was analyzed among the cohort data above. ApoA-I in LpAI negatively correlated with the apoB-lipoprotein parameters such as apoB, triglyceride, nonHDL-cholesterol, and nonHDL-cholesterol + triglyceride, which are apparently reflected in the relations of the total HDL parameters to apoB-lipoproteins. In contrast, apoA-I in LpAI:AII and apoA-II positively correlated to the apoB-lipoprotein parameters even within their small range of variation. These relationships are independent of sex, but may slightly be influenced by the activity-related CETP mutations. The study suggested that LpAI:AII is an atherogenic indicator rather than antiatherogenic. These sub-fractions of HDL are to be evaluated separately for estimating atherogenic risk of the patients.

  12. Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I

    DEFF Research Database (Denmark)

    Douthwaite, Stephen; Jakobsen, Lene; Yoshizawa, Satoko

    2008-01-01

    of Gram-positive bacteria, including the tylosin-producer Streptomyces fradiae and the pathogen Streptococcus pneumoniae. Recombinant S. pneumoniae RlmA(II) was purified and shown to retain its activity and specificity in vitro when tested on unmethylated 23 S rRNA substrates. RlmA(II) makes multiple......RlmA(II) methylates the N1-position of nucleotide G748 in hairpin 35 of 23 S rRNA. The resultant methyl group extends into the peptide channel of the 50 S ribosomal subunit and confers resistance to tylosin and other mycinosylated macrolide antibiotics. Methylation at G748 occurs in several groups...

  13. 30 CFR 57.22204 - Main fan operation and inspection (I-A, II-A, III, and V-A mines).

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main fan operation and inspection (I-A, II-A, III, and V-A mines). 57.22204 Section 57.22204 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... Main fan operation and inspection (I-A, II-A, III, and V-A mines). Main fans shall be— (a) Provided...

  14. 30 CFR 57.22205 - Doors on main fans (I-A, II-A, III, and V-A mines).

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Doors on main fans (I-A, II-A, III, and V-A... main fans (I-A, II-A, III, and V-A mines). In mines ventilated by multiple main fans, each main fan... reversal through the fan. The doors shall be located so that they are not in direct line with explosive...

  15. Apolipoprotein A-II Plus Lipid Emulsion Enhance Cell Growth via SR-B1 and Target Pancreatic Cancer In Vitro and In Vivo

    Science.gov (United States)

    Thanh LE, Thao N.; Gill, Anthony J.; Bulanadi, Jerikho C.; Patel, Mili; Waddington, Lynne J.; Rye, Kerry-Anne; Moghaddam, Minoo J.; Smith, Ross C.

    2016-01-01

    Background Apolipoprotein A-II (ApoA-II) is down regulated in the sera of pancreatic ductal adenocarcinoma (PDAC) patients, which may be due to increase utilization of high density lipoprotein (HDL) lipid by pancreatic cancer tissue. This study examined the influence of exogenous ApoA-II on lipid uptake and cell growth in pancreatic cancer (PC) both in vitro and in vivo. Methods Cryo transmission electron microscopy (TEM) examined ApoA-II’s influence on morphology of SMOFLipid emulsion. The influence of ApoA-II on proliferation of cancer cell lines was determined by incubating them with lipid+/-ApoA-II and anti-SR-B1 antibody. Lipid was labeled with the fluorophore, DiD, to trace lipid uptake by cancer cells in vitro by confocal microscopy and in vivo in PDAC patient derived xenograft tumours (PDXT) by fluorescence imaging. Scavenger receptor class B type-1(SR-B1) expression in PDAC cell lines and in PDAC PDXT was measured by western blotting and immunohistochemistry, respectively. Results ApoA-II spontaneously converted lipid emulsion into very small unilamellar rHDL like vesicles (rHDL/A-II) and enhanced lipid uptake in PANC-1, CFPAC-1 and primary tumour cells as shown by confocal microscopy. SR-B1 expression was 13.2, 10.6, 3.1 and 2.3 fold higher in PANC-1, MIAPaCa-2, CFPAC-1 and BxPC3 cell lines than the normal pancreatic cell line (HPDE6) and 3.7 fold greater in PDAC tissue than in normal pancreas. ApoA-II plus lipid significantly increased the uptake of labeled lipid and promoted cell growth in PANC-1, MIAPaCa-2, CFPAC-1 and BxPC3 cells which was inhibited by anti SR-B1 antibody. Further, ApoA-II increased the uptake of lipid in xenografts by 3.4 fold. Conclusion Our data suggest that ApoA-II enhance targeting potential of lipid in pancreatic cancer which may have imaging and drug delivery potentialities. PMID:27002321

  16. Pracownia Badań i Konserwacji Tkanin Zabytkowych na Uniwersytecie Papieskim Jana Pawła II w Krakowie

    Directory of Open Access Journals (Sweden)

    Natalia Krupa

    2015-12-01

    Full Text Available Pracownia Badań i Konserwacji Tkanin Zabytkowych utworzona została w 2012 roku na Uniwersytecie Papieskim Jana Pawła II, jako jedna z jednostek Instytutu Historii Sztuki i Kultury na Wydziale Historii i Dziedzictwa Kulturowego. Z dniem podjęcia uchwały przez Senat Uniwersytetu Papieskiego Jana Pawła II pracownia rozpoczęła działalność dydaktyczną, naukowo-badawczą i konserwatorską związaną z opieką nad zbiorami tekstyliów kościelnych z obszaru Krakowa i Małopolski.

  17. Proteomic data show an increase in autoantibodies and alpha-fetoprotein and a decrease in apolipoprotein A-II with time in sera from senescence-accelerated mice

    Energy Technology Data Exchange (ETDEWEB)

    Guo, S.J. [Beijing Institute of Pharmacology and Toxicology, Beijing (China); Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (China); Qi, C.H.; Zhou, W.X.; Zhang, Y.X. [Beijing Institute of Pharmacology and Toxicology, Beijing (China); Zhang, X.M.; Wang, J.; Wang, H.X. [National Center of Biomedical Analysis, Beijing (China)

    2013-04-12

    We evaluated changes in levels by comparing serum proteins in senescence-accelerated mouse-prone 8 (SAMP8) mice at 2, 6, 12, and 15 months of age (SAMP8-2 m, -6 m, -12 m, -15 m) to age-matched SAM-resistant 1 (SAMR1) mice. Mice were sacrificed, and blood was analyzed by 2-dimensional electrophoresis combined with mass spectrometry. Five protein spots were present in all SAMP8 serum samples, but only appeared in SAMR1 samples at 15 months of age except for spot 3, which also showed a slight expression in SAMR1-12 m sera. Two proteins decreased in the sera from SAMP8-2 m, -6 m, and -12 m mice, and divided into 2 spots each in SAMP8-15 m sera. Thus, the total number of altered spots in SAMP8 sera was 7; of these, 4 were identified as Ig kappa chain V region (M-T413), chain A of an activity suppressing Fab fragment to cytochrome P450 aromatase (32C2-A), alpha-fetoprotein, and apolipoprotein A-II. M-T413 is a monoclonal CD4 antibody, which inhibits T cell proliferation. We found that M-T413 RNA level was significantly enhanced in splenocytes from SAMP8-2 m mice. This agreed with serum M-T413 protein alterations and a strikingly lower blood CD4{sup +} T cell count in SAMP8 mice when compared to the age-matched SAMR1 mice, with the latter negatively correlating with serum M-T413 protein volume. Age-related changes in serum proteins favored an increase in autoantibodies and alpha-fetoprotein and a decrease of apolipoprotein A-II, which occurred in SAMP8 mice at 2 months of age and onwards. These proteins may serve as candidate biomarkers for early aging.

  18. Proteomic data show an increase in autoantibodies and alpha-fetoprotein and a decrease in apolipoprotein A-II with time in sera from senescence-accelerated mice

    International Nuclear Information System (INIS)

    Guo, S.J.; Qi, C.H.; Zhou, W.X.; Zhang, Y.X.; Zhang, X.M.; Wang, J.; Wang, H.X.

    2013-01-01

    We evaluated changes in levels by comparing serum proteins in senescence-accelerated mouse-prone 8 (SAMP8) mice at 2, 6, 12, and 15 months of age (SAMP8-2 m, -6 m, -12 m, -15 m) to age-matched SAM-resistant 1 (SAMR1) mice. Mice were sacrificed, and blood was analyzed by 2-dimensional electrophoresis combined with mass spectrometry. Five protein spots were present in all SAMP8 serum samples, but only appeared in SAMR1 samples at 15 months of age except for spot 3, which also showed a slight expression in SAMR1-12 m sera. Two proteins decreased in the sera from SAMP8-2 m, -6 m, and -12 m mice, and divided into 2 spots each in SAMP8-15 m sera. Thus, the total number of altered spots in SAMP8 sera was 7; of these, 4 were identified as Ig kappa chain V region (M-T413), chain A of an activity suppressing Fab fragment to cytochrome P450 aromatase (32C2-A), alpha-fetoprotein, and apolipoprotein A-II. M-T413 is a monoclonal CD4 antibody, which inhibits T cell proliferation. We found that M-T413 RNA level was significantly enhanced in splenocytes from SAMP8-2 m mice. This agreed with serum M-T413 protein alterations and a strikingly lower blood CD4 + T cell count in SAMP8 mice when compared to the age-matched SAMR1 mice, with the latter negatively correlating with serum M-T413 protein volume. Age-related changes in serum proteins favored an increase in autoantibodies and alpha-fetoprotein and a decrease of apolipoprotein A-II, which occurred in SAMP8 mice at 2 months of age and onwards. These proteins may serve as candidate biomarkers for early aging

  19. Metabolism of apolipoproteins A-I and A-II in human high-density lipoprotein: a mathematical approach for analysis of their specific activity decay curves

    International Nuclear Information System (INIS)

    Atmeh, R.F.

    1987-01-01

    The differential rate equations describing the compartmental model of human high-density lipoprotein (HDL) were integrated by means of Laplace transforms and an exponential equation was obtained for each of the three compartments. These equations were used to fit the observed plasma decay data and give estimates for the rate constants of the system by means of a written computer program. Furthermore, these estimates were used to calculate the exponential constants of the integrated equations. Consequently, the amount of label in any of the intravascular, extravascular, and urine compartments can be calculated as a fraction of the original dose of label at any time point. This method was tested using data for the (AI)HDL subclass because it contains only apolipoprotein A-I as the major apolipoprotein and does not contain apolipoprotein A-II. The calculated plasma and urine radioactivity data were compared with the experimentally obtained data from two normolipoproteinemic subjects and found to be in good agreement. The significance of this method is its application to the analysis of the decay data of the individual apolipoproteins of (AI + AII) HDL subclass where the urinary radioactivity data resulting from the individual apolipoprotein breakdown on the native particle cannot be measured experimentally at present. Such data are essential for the detailed calculation of the kinetic parameters of these apolipoproteins

  20. Inteligencia Artificial y Neurología: II Parte

    Directory of Open Access Journals (Sweden)

    Mario Camacho Pinto

    1986-12-01

    Full Text Available

    Algunos comentarios sobre la primera parte me han inducido a ampliar las bases de este trabajo mediante la presentación de aspectos comunes y conceptos disímiles sobre la hipotética relación entre inteligencia artificial (lA e inteligencia humana(IH. El tema es tan complejo que un intento por resumirlo de por sí ya es atrayente además de necesario.

    Microhistoria de la lA. Ciñéndome a una cruda realidad la lA nació en la Conferencia de Darmouth, año 1956, cuando John McCarthy, profesor de ciencia de computador en Stanford Un. acuñó el término de lA. Sin embargo, especulando un poco podemos decir que cierta inquietud existió desde la antigüedad, mucho antes de los computadores y aún de la electrónica (1 cuando el ser humano irresistiblemente mostraba inquietud por crear I fuera del cerebro humano. Se encuentran algunos ejemplos en la Mitología griega: Hefestos. dios del fuego y de los metales, confeccionaba creaciones semihumanas en su forja. Pigmalión desencantado de las mujeres modeló su propia ninfa en mármol y para poder casarse con ella imploró suplicante hasta conseguir que Afrodita le diera vida.

    En la Europa medioeval al papa Silvestre II (apodado el hechicero por su sabiduría, año 909 D.C. se le atribuye que construía cabezas parlantes. En el siglo XVI Para celso clamó haber inventado un homúnculo. Y el rabino checo Jundo ben Loew esculpió un hombre en arcilla, José Golem, y lo constituyó espía en Praga. En 1854 el matemático británico George Boole propuso un sistema para describir lógica (2 -las leyes del pensamiento en términos matemáticos: “álgebra booliana”, “mathematical logics” que representa procesos lógicos con dos dígitos, 9 y 1.

    En 1937 Alan Turing demostró que una máquina binaria podía ser programada para realizar cualquier tarea algorítmica. Esta máquina de Turing sólo podía ejecutar dos acciones: dibujar y borrar. En el mismo año Claude Shannon, graduado en el MIT, descubrió que era posible lograr resultados similares con relés eléctricos que integró en circuitos al sistema binario de almacenamiento de información, lo que dio la medida para que en 1943 se construyera el primer computador digital Harvard Mark I para computación matemática con los dígitos O y 1. En 1945 el matemático americano John Von Newman informó sobre su diseño EDV AC (Electronic Discrete Variable Computer de estructura lógica para procesar información y hoy en día se conserva su variable de procesamiento secuencial a la que últimamente se ha agregado otra imitada del cerebro, que es el procesamiento paralelo de que hablé en la primera parte y que ha dado en manos en Brattle Research Co. “velocidad fantástica en procesamiento” (3. En 1948 Wiener del MIT corrigió a Newton porque desde su tiempo los científicos estaban concentrados en un modelo de energía cuya transferencia explicaba eventos y procesos. Wiener cambió este concepto por el de transferencia de información y control denominando este enfoque Cibernética (4. Por intercambio de información dedujo la existencia de similaridades funcionales entre humanos y máquinas, noción invaluable en las tempranas investigaciones sobre IA.

    Con los progresos de la tecnología electrónica Eniac reemplazó los relés de Mark I por tubos al vacío y denominó su computador primera generación (1. La segunda generación fue la basada en el transistor semiconductor. La tercera en los circuitos integrados (IC’s. La cuarta en los circuitos de muy grande escala de integración (VLSI, de los cuales una sola capa delgada o “chip” puede contener cientos de miles de circuitos on and off, O ó 1, lo que significa mejor tecnología pero el concepto permanece el mismo.

    En el verano de 1956 se celebró una conferencia en la sede del Darmouth College, New Hampshire, entre una docena de “revolucionarios” matemáticos, neurólogos, psicólogos e ingenieros eléctricos, eruditos usuarios de computadores que tenían en común el empeño de simular varios aspectos de la IH; decidieron unificar esfuerzos pero no se ponían de acuerdo en la denominación de la nueva ciencia hasta cuando J ohn McCarthy sugirió el término de lA, bautizando así esta rama de la ciencia computada. Organizaron esta conferencia (5 McCarthy de Stanford, Marvin Minsky de Harvard, ambos graduados en Princeton y fundadores de la AAAI (American Association for Artificial Intelligence; Nataniel Rochester de IBM y Claude Shannon de Lab. Bell...

  1. Maailmamajanduse konjunktuur : 2006. a. II ja III kv / B Pulver

    Index Scriptorium Estoniae

    Pulver, B

    2006-01-01

    Lühiülevaade maailmamajanduse konjunktuurist 2006. aasta II ja III kvartalis on koostatud Müncheni Majandusuuringute Instituudi väljaande World Economic Survey nr 92 alusel. 2006. a. aprilli vaatlus näitas maailma majanduskliima paranemist. Tabelid: Ekspertide hinnangud aprillis 2006 (max=9); Arenenud riikide majandusindikaatorid; Konjunktuuribaromeetrite kindlustunde indikaatorid Euroopa Liidu maades

  2. The influence of Na2O on the hydration of C3A II. Suspension hydration

    NARCIS (Netherlands)

    Spierings, G.A.C.M.; Stein, H.N.

    1976-01-01

    The influence of Na2O on the hydration of C3A was studied in suspensions from the start of the reaction onwards. The heat evolution rate in very early stages of the hydration, measured at varying NaOH concentrations, and SEM, indicate that at NaOH concentrations larger then 0.1 M the reaction

  3. Monitoreo neurointensivo en pediatría (II: Pruebas dinámicas

    Directory of Open Access Journals (Sweden)

    Eduardo M. Pleguezuelo Rodríguez

    2001-06-01

    Full Text Available El traumatismo craneoencefálico grave (TCEG continúa siendo la principal causa de muerte y discapacidad en pediatría, de la misma manera es el factor determinante del pronóstico en niños con trauma multisistémico, no sólo al llevar a la desaparición del ser físico, sino que deja en ocasiones en estados limítrofes entre la vida y la muerte como son los llamados estados vegetativos. En las últimas décadas se ha revolucionado el modo de tratamiento de estos pacientes, pasando del tratamiento neuroquirúrgico convencional, el cual se realizaba en salas de neurocirugía y se comportaba con una mortalidad mayor del 70 %, al tratamiento neurointensivo, Unidad de Cuidados Intensivos (UCI, y se define por el neuromonitoreo continuo, intensivo e invasivo, que permite identificar una serie de fenómenos fisiopatológicos que son diferentes para cada paciente y de esta manera tratarlos de forma racional, con lo cual se ha conseguido reducir la mortalidad a niveles inferiores al 30 %. Después de más de 5 años de experiencia con esta metodología, en el Hospital Provincial General de la provincia de Camagüey, y más de 2 años de realizar ésta en el Hospital Pediátrico provincial Docente, se decidió en este trabajo describir detalladamente la forma de realizar el monitoreo, así como los valores normales, utilidad clínica y las principales desviaciones patológicas de las variables más importantes en el neuromonitoreo intensivo, como son: presión intracraneal (PIC, hemodinámicas, metabólicas, las cuales pueden ser realizadas con modestos recursos, disponibles en la mayoría de nuestras salas de terapia intensiva. Este segundo trabajo recoge de forma muy sintética un determinado número de pruebas dinámicas y monitoreo del hemometabolismo cerebral de O2 que podemos realizar en el monitoreo de la PIC a pacientes con traumatismo craneoencefálico grave.Severe carnioencephalic trauma (SCET is still the main cause of death and disability in Pediatrics. It is also the determinant of prognosis in children with multisystemic trauma, producing not only death, but leaving the child in limiting states between life and death as the so-called vegetative states. During the last decades the treatment of these patients has been revolutionized and it has passed from the conventional neurosurgical treatment, which was received at the neurosurgery wards and had a mortality over 70 %, to the neurointensive treatment, which is given at the Intensive Care Unit (ICU and is defined by continuous, intensive and invasive neuromonitoring that allow to identify a series of physiopathological phenomena different for each patient and to treat patients in a rational way. This has made possible to reduce mortality to less than 30 %. After more than 5 years of experience with this methodology at the Provincial General Hospital of Camagüey and more than 2 years of its application in the Provincial Pediatric Teaching Hospital, it was decided to describe in detail in this paper the way to monitor the patient, as well as the normal values, clinical usefulnesss and the main pathological deviations of the most important variables in the neurointensive monitoring, such as: intracranial pressure (ICP, hemodynamic and metabolic variables that may be attained with modest resources available in most of our intensive care units. This second paper includes in a very synthesized way a specific number of dynamic tests and monitoring of the cerebral oxygen hemometabolism that can be made during the monitoring of ICP in patients with severe cranioencephalic trauma.

  4. The ultra-long GRB 111209A. II. Prompt to afterglow and afterglow properties

    Energy Technology Data Exchange (ETDEWEB)

    Stratta, G. [Osservatorio Astronomico di Roma (OAR/INAF), via Frascati 33, I-00040 Monte Porzio Catone (Italy); Gendre, B.; Boër, M. [ARTEMIS, UMR 7250 (CNRS/OCA/UNS), boulevard de l' Observatoire, BP 4229, F-06304 Nice Cedex (France); Atteia, J. L. [Université de Toulouse, UPS-OMP, IRAP, F-31400 Toulouse (France); Coward, D. M.; Howell, E. [School of Physics, University of Western Australia (UWA), Crawley, WA 6009 (Australia); De Pasquale, M.; Oates, S. [Mullard Space Science Laboratory (MSSL), University College London, Holmbury St. Mary, Dorking, Surrey RH5 6NT (United Kingdom); Klotz, A. [IRAP, 14, avenue Edouard Belin, F-31400 Toulouse (France); Piro, L. [Istituto di Astrofisica e Planetologia Spaziali di Roma (IAPS/INAF), via fosso del cavaliere 100, I-00133 Roma (Italy)

    2013-12-10

    The 'ultra-long' gamma-ray burst GRB 111209A at redshift z = 0.677 is the longest GRB ever observed thus far, with a rest frame prompt emission duration of ∼4 hr. In order to explain the burst exceptional longevity, a low-metallicity blue supergiant progenitor was invoked. In this article we further constrain the phenomenology and progenitor properties of this peculiar GRB by performing a multiband temporal and spectral analysis of both the prompt and the afterglow emission. We use proprietary and publicly available data from Swift, Konus WIND, XMM-Newton, and TAROT, as well as from other ground-based optical and radio telescopes. We find some peculiar properties that are possibly connected to the exceptional nature of this burst, namely: (1) an unprecedented large optical delay of 410 ± 50 s between the peak time in gamma-rays and the peak time in the optical of a marked multiwavelength flare; (2) multiwavelength prompt emission spectral modeling requires a certain amount of dust in the circumburst environment. The dust produces a rest frame visual extinction of A{sub V} = 0.3-1.5 mag, and may undergo destruction at late times; and (3) we detect the presence of a hard spectral extra power-law component at the end of the X-ray steep steep decay phase and before the start of the X-ray afterglow, which has never been revealed thus far in past GRBs. The optical afterglow shows more usual properties; it has a flux power-law decay with an index of 1.6 ± 0.1 and a late rebrightening feature observed at ∼1.1 the day after the first Burst Alert Telescope trigger. We discuss our findings in the context of several possible interpretations that have been given thus far of the complex multiband GRB phenomenology and propose a binary channel formation for the blue supergiant progenitor.

  5. The ultra-long GRB 111209A. II. Prompt to afterglow and afterglow properties

    International Nuclear Information System (INIS)

    Stratta, G.; Gendre, B.; Boër, M.; Atteia, J. L.; Coward, D. M.; Howell, E.; De Pasquale, M.; Oates, S.; Klotz, A.; Piro, L.

    2013-01-01

    The 'ultra-long' gamma-ray burst GRB 111209A at redshift z = 0.677 is the longest GRB ever observed thus far, with a rest frame prompt emission duration of ∼4 hr. In order to explain the burst exceptional longevity, a low-metallicity blue supergiant progenitor was invoked. In this article we further constrain the phenomenology and progenitor properties of this peculiar GRB by performing a multiband temporal and spectral analysis of both the prompt and the afterglow emission. We use proprietary and publicly available data from Swift, Konus WIND, XMM-Newton, and TAROT, as well as from other ground-based optical and radio telescopes. We find some peculiar properties that are possibly connected to the exceptional nature of this burst, namely: (1) an unprecedented large optical delay of 410 ± 50 s between the peak time in gamma-rays and the peak time in the optical of a marked multiwavelength flare; (2) multiwavelength prompt emission spectral modeling requires a certain amount of dust in the circumburst environment. The dust produces a rest frame visual extinction of A V = 0.3-1.5 mag, and may undergo destruction at late times; and (3) we detect the presence of a hard spectral extra power-law component at the end of the X-ray steep steep decay phase and before the start of the X-ray afterglow, which has never been revealed thus far in past GRBs. The optical afterglow shows more usual properties; it has a flux power-law decay with an index of 1.6 ± 0.1 and a late rebrightening feature observed at ∼1.1 the day after the first Burst Alert Telescope trigger. We discuss our findings in the context of several possible interpretations that have been given thus far of the complex multiband GRB phenomenology and propose a binary channel formation for the blue supergiant progenitor.

  6. The Ultra-long GRB 111209A. II. Prompt to Afterglow and Afterglow Properties

    Science.gov (United States)

    Stratta, G.; Gendre, B.; Atteia, J. L.; Boër, M.; Coward, D. M.; De Pasquale, M.; Howell, E.; Klotz, A.; Oates, S.; Piro, L.

    2013-12-01

    The "ultra-long" gamma-ray burst GRB 111209A at redshift z = 0.677 is the longest GRB ever observed thus far, with a rest frame prompt emission duration of ~4 hr. In order to explain the burst exceptional longevity, a low-metallicity blue supergiant progenitor was invoked. In this article we further constrain the phenomenology and progenitor properties of this peculiar GRB by performing a multiband temporal and spectral analysis of both the prompt and the afterglow emission. We use proprietary and publicly available data from Swift, Konus WIND, XMM-Newton, and TAROT, as well as from other ground-based optical and radio telescopes. We find some peculiar properties that are possibly connected to the exceptional nature of this burst, namely: (1) an unprecedented large optical delay of 410 ± 50 s between the peak time in gamma-rays and the peak time in the optical of a marked multiwavelength flare; (2) multiwavelength prompt emission spectral modeling requires a certain amount of dust in the circumburst environment. The dust produces a rest frame visual extinction of AV = 0.3-1.5 mag, and may undergo destruction at late times; and (3) we detect the presence of a hard spectral extra power-law component at the end of the X-ray steep steep decay phase and before the start of the X-ray afterglow, which has never been revealed thus far in past GRBs. The optical afterglow shows more usual properties; it has a flux power-law decay with an index of 1.6 ± 0.1 and a late rebrightening feature observed at ~1.1 the day after the first Burst Alert Telescope trigger. We discuss our findings in the context of several possible interpretations that have been given thus far of the complex multiband GRB phenomenology and propose a binary channel formation for the blue supergiant progenitor.

  7. 30 CFR 57.22207 - Booster fans (I-A, II-A, III, and V-A mines).

    Science.gov (United States)

    2010-07-01

    ... requirements of 30 CFR part 18, and be— (1) Provided with an automatic signal device located so that it can be... open automatically when all fans in the installation stop; and (2) Provided with an air lock when...

  8. Novedades sobre el género Pilosella Hill.: (Asteraceae, Lactuceae) en España, II

    OpenAIRE

    Mateo Sanz, Gonzalo

    2016-01-01

    Se comunica la presencia de diversas especies nuevas del género Pilosella Hill. (Asteraceae, Lactuceae) en España. Novelties on the genus Pilosella Hill (Asteraceae, Lactuceae) in Spain, II. Several species of Pilosella Hill (Asteraceae, Lactuceae) found in Spain.

  9. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Science.gov (United States)

    2010-07-01

    ... METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Fire Prevention and Control § 57.22103...

  10. 30 CFR 57.22101 - Smoking (I-A, II-A, III, and V-A mines).

    Science.gov (United States)

    2010-07-01

    ... METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Fire Prevention and Control § 57.22101...

  11. Judgement of November 18, 1980 -7 A II 17/80- (encroachment upon claimant's rights through Atomic Energy Law permits)

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    With its decision of November 18, 1980, the Superior Administrative Court of the Rhineland-Palatinate has dismissed a suit requesting an appeal of licensing for the Muehlheim-Kaerlich nuclear power plant which had already been rejected previously by a lower court. In its decision, the court emphasized the point that all judicial and procedural guarantees for legal action, as defined in the Constitution, article 19, sub-section 4, and as stated in the administrative rules of court procedures, are limited to the protection of individuals against any infringement of their rights. Should the plaintiff, as is here the case, appear as a representative of the common interest, his court action becomes inadmissable, based on the need for a case of general legal protection. In addition, the complaint lacks defined needs for legal aid and protection, the court maintains. The plaintiff was not able to prove a violation of his own rights, and thus would have neither a justifiable interest in determining the validity of the disputed administrative measures (administrative rules of court section 43, sub-section 1) as he could, were he be authorized to contest this decision (administrative rule of court, section 42, sub-section 2). (GA) [de

  12. El deporte y la podología: tendencias actuales en Ortopodología II (segunda parte)

    OpenAIRE

    Céspedes Céspedes, Tomás; Dorca Coll, Adelina; Cuevas Gómez, Rafael; Sacristán Valero, Sergi

    1993-01-01

    Siguiendo el guión expuesto en la primera parte de la ponencia, procederemos a la exposición de varios casos clínicos, a través de los cuales queremos mostrarles los avances e innovaciones más recientes en la ortopodología.

  13. PENGARUH PERLAKUAN DELIGNIFIKASI DENGAN LARUTAN NAOH DAN KONSENTRASI SUBSTRAT JERAMI PADI TERHADAP PRODUKSI ENZIM SELULASE DARI ASPERGILLUS NIGER NRRL A-II, 264

    Directory of Open Access Journals (Sweden)

    IDA BAGUS WAYAN GUNAM

    2010-12-01

    Full Text Available his research was done in order to utilize agricultural waste (rice straw as substrate to produce crude cellulase enzyme from Aspergillus niger. This research was conducted in two stages; the first stage was determination of the initial pH and fermentation time by pH treatment (5, 6 and 7 and fermentation time (7, 9 and 11 days. The second stage was determination of concentration of NaOH treatment and concentration of substrate, namely: concentrations of NaOH (2, 4 and 6% and concentrations of substrate (1, 2 and 3% (w/v. The results showed that the fermentation time of 9 days with the initial pH 6.0 was the optimal condition for production of crude cellulase enzyme from A. niger with rice straw as a substrate. The highest enzyme activity derived from interaction of delignification treatment with NaOH concentration of 6% and 2% rice straw substrate which produces endoglukanase enzyme activity (0.037 units/ml, filter paperase activity (0.033 units/ml, soluble protein (0.362 mg/ml, and specific activity of filter paperase (0.123 units/mg.

  14. Multicolor (UV-IR) Photodetectors Based on Lattice-Matched 6.1 A II/VI and III/V Semiconductors

    Science.gov (United States)

    2015-08-27

    copyright information. 13. SUPPLEMENTARY NOTES. Enter information not included elsewhere such as: prepared in cooperation with; translation of; report...II-VI heterojunctions such as multi-color photodetectors and solar cells [2]. Mixing lattice-matched II-VI and III-V semiconductors could be an...at 77 K, further silicon oxide surface passivation can be done to suppress the surface leakage [10] in the future work. Figure 10 The dark I-V

  15. Studies on the mechanism of the epileptiform activity induced by U18666A. II. concentration, half-life and distribution of radiolabeled U18666A in the brain

    Energy Technology Data Exchange (ETDEWEB)

    Cenedella, R.J.; Sarkar, C.P.; Towns, L.

    1982-06-01

    The concentration, half-life, and distribution in brain of U18666A, a drug that can drastically alter cerebral lipids and induce a chronic epileptiform state, was determined following both acute and chronic drug administration. U18666A specifically labeled with tritium was prepared by custom synthesis. Brain levels of 1 x 10(-6)M and higher were reached soon after giving an acute 10-mg/kg dose (i.p. or s.c.) of U18666A containing 7-/sup 3/H-U18666A of known specific activity. A steady state concentration of 1 to 2 x 10(-6)M was reached with chronic injection of 10 mg/kg every 4th day, a treatment schedule that results in altered brain lipids and induction of epilepsy if begun soon after birth. The disappearance of U18666A from both brain and serum was described by two similar biexponential processes, a brief rapid clearance (t1/2 . 10 h) and a sustained and much slower one (t1/2 . 65 h). Brain levels of the drug were about 10 times higher than serum at all times examined. Few differences were seen in the regional distribution of radiolabeled drug in brain as determined by both direct analysis and by autoradiographic examination; but the drug did concentrate in lipid-rich subcellular fractions. For example, the synaptosome and myelin fractions each contained about 25-35% of both the total /sup 3/H-labeled drug and total lipid in whole brain. The lipid composition of these fractions was drastically altered in treated animals. In conclusion, the chronic epileptiform state induced by U18666A does not appear to involve localization of the drug in a specific brain region or particular cell type. Rather, the condition could involve localization of the drug in lipid-rich membranes and marked changes in the composition of these membranes.

  16. Filme din ţările Puterilor Centrale pe ecranele din Bucureştii ocupaţi (1916–1918. Partea a II-a

    Directory of Open Access Journals (Sweden)

    Ionescu

    2017-10-01

    Full Text Available Once Romania joined the war, alongside with the Allies, by the end of the summer of 1916, the cinema theatres were closed, like all other places of entertainment. This was a significant blow to townsfolk used to spend their free time in theatre halls. However, it did not last long, because on September 11, they are reopened on special schedules, only from 3 to 6 p.m. In the first days of October, patriotic and propaganda films like ”Martiriul Românilor din Ardeal” (The Martyrdom of Romanians in Transylvania, were being run. In the first decade of the next month, it was announced the work on the ”historic and patriotic film the Great War for the Liberation of the Romanian Nation”, which followed to contain scenes of the recent fighting on the front. The film was expected to be released on November 14 at ”Zaharia” cinema theatre. However, the situation on the front was not favourable for the Romanian armies and soon the enemy occupied the south of the country. The German occupational civil and military administration intended to make of Romania an example of good management and judicious care for the welfare and contentment of mind of the residents – even if all this was mere propaganda.

  17. The validity of John Paul II’s concept of education in a family [Aktualność Jana Pawła II koncepcji wychowania w rodzinie

    Directory of Open Access Journals (Sweden)

    Anastazja SORKOWICZ

    2017-11-01

    Full Text Available Searching for a concept of education in a family occupies not only theorists of education but also parents and those persons with a lively interest in practical activities directed to helping families. The Holy Father John Paul II presented a Christian perspective of family and education: He treated the family as an inseparable relationship between a woman and a man, directed from one side towards the good of the spouses and from the other towards the transmission of life to children. Education, as understood by John Paul II, is one of the basic aims of a family, it is one of its most important tasks. The process relies on mutual gift of one’s humanity and takes place during interactions between family members. The success of educational process in a family depends on the quality of relationship between parents: whether spouses – parents take trouble to establish and maintain a true community of persons, whether their relationship is based on mutual trust. Parenthood is understood by John Paul II as a gift and as a task, from which follows the basic right, and simultaneously an obligation, to educate children in accordance with one’s beliefs. This task is of such importance that it should not be appropriated by any other entity. Therefore parents are the first and most important educators of their children, responsible for forming in the younger generation the spirit of universal values. The article is to make the reader more familiar with the teaching of John Paul II concerning education in the family and indicate the elements of this teaching which are especially valid for a human being living at the beginning of the XXIth century and searching for the universal concept of education in the family.

  18. Extensive literature search on cropping practices of host plants of some harmful organisms listed in Annex II A II of Directive 2000/29/EC

    NARCIS (Netherlands)

    Derkx, M.P.M.; Brouwer, J.H.D.; Breda, van P.J.M.; Heijerman-Peppelman, G.; Heijne, B.; Hop, M.E.C.M.; Wubben, C.F.M.

    2014-01-01

    The European Commission is currently seeking advice from EFSA (Mandate M-2012-0272) to assess for Arabis mosaic virus, Raspberry ringspot virus, Strawberry latent ringspot virus, Tomato black ring virus, Strawberry mild yellow edge virus, Strawberry crinkle virus, Daktulosphaira vitifoliae,

  19. U.S. Workshop on the Physics and Chemistry of II-VI Materials (a.k.a. II-VI Workshop) - ARO Research Area 9: Materials Science - Physical Properties of Materials

    Science.gov (United States)

    2015-12-21

    integrated into arrays and can be fabricated on various substrates including glass . This makes it well suited for constructing photodetector-arrays for...energy forming a stable TeO2 , but the Cd 3d doublet remained the same. We also analyzed the diffusion profile of the contact metals that were...The devices in this study were made on Corning® Willow® Glass , which is a highly transparent, flexible, hermetic, and dimensionally stable

  20. Pavlov (okr. Břeclav). Okolí obce-lokality Pavlov I a II. zpracování nového materiálu (paleoantropologie)

    Czech Academy of Sciences Publication Activity Database

    Svoboda, Jiří; Novák, Martin; Čulíková, Věra; Kovanda, J.; Roszková, A.

    2010-01-01

    Roč. 2010, č. 51 (2010), s. 290-294 ISSN 1211-7250 R&D Projects: GA ČR GA404/08/0045 Institutional research plan: CEZ:AV0Z80010507; CEZ:AV0Z80020508 Keywords : Gravettian * site periphery * environment * dating Subject RIV: AC - Archeology, Anthropology, Ethnology

  1. Prevalencia de los genotipos fimA II y fimA IV de Porphyromonas gingivalis en un grupo de mujeres mexicanas con diabetes gestacional en la región centro de México

    OpenAIRE

    García-Reyna,Roberto Arturo; Terrones Saldivar,María del Carmen; Malacara-Rosas,Angélica María; Zaragoza-Velásquez,Nicolás; Rosas-Cabral,Alejandro; Gutiérrez Campos,Rafael

    2014-01-01

    La diabetes gestacional (DG) es una de las complicaciones médicas que más frecuentemente afectan a las mujeres embarazadas; algunos autores reportan una prevalencia entre el 9,7 y el 13,9%. La DG puede ser causa de efectos adversos como: nacimiento pretérmino, macrosomia, nacimiento por cesárea, hiperbilirrubinemia, hipertensión gestacional, así como la predisposición de desarrollar posteriormente diabetes mellitus tipo 2 y síndrome metabólico. La literatura señala la asociación entre los mic...

  2. Rola wychowania fizycznego w budowaniu świadomości w zakresie aktywności fizycznej uczniów Gimnazjum im. Jana Pawła II w Mroczy = The role of physical education to build awareness of physical activity students Gymnasium named John Paul II in Mrocza

    Directory of Open Access Journals (Sweden)

    Agata Jędrzyńska

    2015-09-01

      Słowa kluczowe: wychowanie fizyczne, aktywność fizyczna, kultura fizyczna, świadomość, edukacja, styl życia, zdrowie.   Abstract The theme of the work is the impact of participation in physical education classes on the process of building awareness of physical activity. The test group is a third grade students Gymnasium named John Paul II in Mrocza. The goal, which prevailed during the adoption of this theme was to examine the extent to which participation in the classes of physical education affects the overall development of a young man in a particular school and the determination of the ratio of teenagers to make physical activity. In the case of third-country students in grades Gymnasium – and you can bet that the problem also applies to the other levels of learning – a large part of students resigns from active participation in lessons of wf, the most trivial of reasons. Imposes on puberty, so a tough time for students in terms of changes in their psyche. It's also a difficult time for parents and educators, requires them to substantial attention and understanding the sources of the behavior of young people. Physical education no doubt is of the utmost importance in the overall educational process. Therefore, it is important that the various levels of education the student in terms of physical activity habits desirable bought and awareness of preventive treatment, because later on in life, in the case of neglect in this area, it will be harder in itself arouse. From the analysis it can be concluded that young people have the potential physical and intellectual, to adulthood to be active and healthy people. However, this condition is conscious of creating habits that in the future it will be condition.   Keywords: physical education, physical activity, physical culture, consciousness, education, lifestyle, health.

  3. Hipervitaminose A experimental no rato. I. Estudo cariometrico do epitelio dos tubulos contorcidos proximal distal e alça de Henle do rim de fetos cujas mães foram tratadas com diferentes dosagens de vitamina A. II. Estudo da relação dose-efeito

    OpenAIRE

    Olinda Maria Gomes da Costa Vilas Boas

    1992-01-01

    Resumo: O presente trabalho teve como objetivo caracterizar morfológica e morfométricamente as alterações de volumes nucleares no epitélio dos túbulos contorcidos e alças de Renle, causadas pela hipervitaminose A em rins de fetos de ratas tratadas com diferentes doses de vitamina A. Para tanto, foram utilizados 42 fetos de ratas que, no décimo dia de prenhez receberam, intraperitonealmente, 30.000 VI, 40.000 VI, 50.000 VI, 70.000 VI, 100.000 VI ou 150.000 VI de vitamina A, sob a forma de palm...

  4. Effects of increasing dietary fiber on digestibility, performance and carcass characteristics: II. prepuberty and puberty gilts/ Efeitos do incremento de fibra dietética sobre digestibilidade, desempenho e características de carcaça: II. fêmeas suínas em prépuberdade e puberdade

    Directory of Open Access Journals (Sweden)

    Soraia Marques Putrino

    2007-08-01

    Full Text Available Female pigs that are intended to be used as sows have to follow a dietary plan that restricts caloric intake. Roughages due to their high content of fiber are low energy sources for swine. This feeding strategy gets around the excessive body fat accumulation. Aiming to study these aspects, prepuberty and puberty gilts were fed isoenergetic and isoproteic rations containing 0; 6.6; 13.2 and 19.8% of neutral detergent fiber (NDF, obtained with the inclusion of coast-cross hay. Twenty crossbred gilts were assigned to a randomized block design experiment which lasted 97 days. Then, the animals were slaughtered. Increment of NDF reduced linearly body weight gain (0.675; 0.607; 0.525; 0.483 g/day; body weight on first physiological heat onset (118.0; 114.0; 102.2; 98.2 kg and worsened feed conversion (3.6; 4.0; 4.7; 5.3. It was observed a quadratic response on the backfat thickness (3.28; 3.34; 2.82; 1.74 cm. There was no effect over the age of first physiological heat onset (203 days and hot carcass yield; however, quadratic response for cold carcass yield was obtained (79.79; 80.24; 79.58; 77.40% and lean meat yield (54.45; 54.35; 55.51; 58.31%. Increasing content of NDF reduced linearly dry matter digestibility (76.23; 67.23; 55.83; 55.73% and NDF digestibility (56.63; 44.24; 34.17; 39.12%; there were quadratic responses to crude protein (72.16; 64.46; 53.52; 62.74% and crude energy digestibilities (71.95; 61.23; 49.21; 53.81%. Gilts body condition was not affected by continuous offering of fibrous ration during prepuberty and puberty phases.Fêmeas suínas destinadas à reprodução devem seguir um plano de restrição alimentar objetivando controlar excessiva ingestão calórica. Emprego de alimentos volumosos, devido ao seu alto teor de fibra, fornece menor aporte de energia para suínos. Esta estratégia alimentar contorna o problema da acumulação excessiva de gordura corporal. Objetivando estudar estes aspectos, fêmeas pré-púberes e púberes foram alimentadas com rações isoenergéticas e isoprotéicas contendo 0; 6,6; 13,2 e 19,8% de fibra em detergente neutro (FDN, obtidas pela inclusão de feno de coast-cross. Vinte marrãs mestiças foram empregadas em um delineamento experimental de blocos casualizados, que durou 97 dias. Após, os animais foram sacrificados. O incremento de FDN na ração diminuiu o ganho de peso linearmente (0,675; 0,607; 0,525; 0,483 g/dia; o peso corporal ao primeiro cio útil (118,0; 114,0; 102,2; 98,2 kg e piorou a conversão alimentar (3,6; 4,0; 4,7; 5,3. Observou-se resposta quadrática na espessura de toucinho (3,28; 3,34; 2,82; 1,74 cm. Não houve efeito sobre a idade de ocorrência do primeiro cio útil (203 dias e no rendimento de carcaça quente; entretanto, foram obtidas respostas quadráticas para o rendimento de carcaça fria (79,79; 80,24; 79,58; 77,40% e de carne magra (54,45; 54,35; 55,51; 58,31%. Níveis crescentes de FDN reduziram linearmente os coeficientes de digestibilidade da matéria seca (76,23; 67,23; 55,83; 55,73% e da fibra em detergente neutro (56,63; 44,24; 34,17; 39,12%; houve respostas quadráticas para a proteína bruta (72,16; 64,46; 53,52; 62,74 % e energia bruta (71,95; 61,23; 49,21; 53,81%. A condição corporal necessária para fêmeas reprodutoras não foi prejudicada pelo oferecimento de ração fibrosa durante as fases de pré-puberdade e puberdade.

  5. La cultura política del ciudadano y la comunicación política en TV en la transición política del plebiscito chileno (octubre 1988. I. Metodología. II. Conclusiones

    Directory of Open Access Journals (Sweden)

    JOSÉ LUIS PIÑUEL RAIGADA

    1990-01-01

    Full Text Available Exposición de la acotación material y formal del objeto al que se destina la investigación realizada, y cuyo campo de observación es la situación histórica brindada con la campaña política del plebiscito chileno del 5 de octubre de 1988. La prefiguración teórica de este objeto es la responsable de la selección y consistencia de los datos que se han recolectado y procesado, y la que ha motivado a escoger como campo de observación la COMUNICACIÓN POLÍTICA televisiva y la CULTURA POLÍTICA del ciudadano en el Chile Plebiscitario. De la investigación se concluye que la Mediación comunicativa del Plebiscito ha implantado en la Transición chilena un proceso de resignificación cuyo sentido radica más en la "afirmación del cambio" que en la "afirmación de opciones contra", curiosamente ligadas estas últimas, por la vía de la comunicación, a la opción política cuya práctica no era de cambio, sino de continuidad.

  6. Critical thinking and accuracy of nurses' diagnoses. Part II: application of cognitive skills and guidelines for self-development Pensamiento crítico y precisión de los diagnósticos de enfermería. II Parte: aplicación de habilidades cognitivas y guia para el autodesarrollo Pensamento crítico e acurácia dos diagnósticos de enfermagem. Parte II: aplicação de habilidades cognitivas e guia para o auto-desenvolvimento

    Directory of Open Access Journals (Sweden)

    Margaret Lunney

    2003-09-01

    Full Text Available Part I of this article, the author explained the difficulties of achieving accuracy of nurses' diagnoses, the relevance of critical thinking to the achievement of accuracy, and newer views of critical thinking. In Part II, the critical thinking dimensions identified as important for nursing practice are applied in the diagnostic process using a case study of a 16 year old girl with type 1 diabetes. Application of seven cognitive skills and ten habits of mind illustrate the importance of using critical thinking for accuracy of nurses' diagnoses. Ten strategies are proposed for self-development of critical thinking abilities.En la I Parte del artículo, el autor explicó las dificultades para alcanzar la precisión de los diagnósticos de enfermería, la relevancia del pensamiento crítico en el logro de esa precisión y las nuevas perspectivas de ese pensamiento. En la II Parte las dimensiones del pensamiento crítico, consideradas como importantes para la práctica de enfermería, son aplicadas en el estudio de caso de una joven de 16 años con Diabetes de tipo 1. La aplicación de las siete habilidades cognitivas y de las diez formas de pensar, ilustra la importancia del uso del pensamiento crítico para la precisión de los diagnósticos de enfermería. Se proponen diez estratégias para el auto-desarrollo de habilidades volcadas al pensamiento crítico.Na Parte I deste artigo, o autor explicou as dificuldades em alcançar a acurácia dos diagnósticos de enfermagem, a relevância do pensamento crítico no alcance dessa acurácia e as mais novas perspectivas desse pensamento. Na Parte II, as dimensões do pensamento crítico identificadas como importantes para a prática de enfermagem são aplicadas em um estudo de caso de uma menina de 16 anos com Diabetes do tipo 1. A aplicação das sete habilidades cognitivas e das dez formas de pensar ilustram a importância do uso do pensamento crítico para a acurácia dos diagnósticos de enfermagem. Dez estratégias são propostas para o auto-desenvolvimento de habilidades para o pensamento crítico.

  7. Phase diagrams for systems Cu2S-AIIS (AII=Mg, Ca, Sr, Ba)

    International Nuclear Information System (INIS)

    Andreev, O.V.; Sikerina, N.V.; Solov'eva, A.V.

    2005-01-01

    By the methods of physicochemical analysis phase diagrams of Cu 2 S-A II S (A II =Mg, Ca, Sr, Ba) systems are studied. The system Cu 2 S-SrS is of eutectic type with eutectic coordinates 1095 K and 21.5 mol.% of SrS. Solubility of SrS in Cu 2 S is 2 mol.% at 1095 K. Regularities of phase diagram changes of Cu 2 S-A II S (A II =Mg, Ca, Sr, Ba) system are determined. Thermodynamic analysis is done [ru

  8. Dicty_cDB: CFG476 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lts*pkvkkfhsqfh*nht lihhllmmvihtiqlafhfkdsiexilcyysi Translated Amino Acid sequence (All Frames) Frame A: ii...pststf*vlkksfqilklts*pkvkkfhsqfh*nht lihhllmmvihtiqlafhfkdsiexilcyysi Frame C: ns*NLFFIVLNIFFKMKKIILFLTVLLVL

  9. 77 FR 69613 - International Energy Agency Meeting

    Science.gov (United States)

    2012-11-20

    ... Policy and Conservation Act (42 U.S.C. 6272(c)(1)(A)(i)) (EPCA), the following notice of meeting is... the IEA 2. IEA Emergency Response Policies, Market Assessment, Industry Perspective 3. IEA Oil Data...)(A)(ii) of the Energy Policy and Conservation Act (42 U.S.C. 6272(c)(1)(A)(ii)), the meeting of the...

  10. Introductory statement: Of receptors and analogs in renin-angiotensin-aldosterone and adrenergic systems

    International Nuclear Information System (INIS)

    Eliahou, H.E.; Iaina, A.

    1980-01-01

    This article reports on the role of the octapeptides angiotensin II (A II)-effector and its receptor on hypertensive patients and in animal experiments. By applying the A-II-receptor blockers, vasodilates drugs, β-receptor blockers and by sodium depletion, the behaviour of the blood pressure, the plasmareninactivity, and of the aldosteron were investigated; a comparative investigation between the A II and A III effectors was also carried out. The iodo-hippurate uptake was reduced with an artificially produced renal arterial ischemia. In general, this investigation provided new viewpoints in the understanding of the possible pathogenetic mechanism of essential hypertonism. (APR) [de

  11. U. S. Pacific Fleet. Central Pacific Force. Operation Plan Number Cen 1-43

    Science.gov (United States)

    1943-10-25

    Wareagle Snowflake Stork Beagle v Jocko Bagdad Frolic Locust Tycoon Vulture Dodger Husky Trojan Harpoon Designation or Commander A-II-2 COMM. A...Tiptop Killnrney Saskatoon Dodger Boar lake Titvdllow Beagle Huniboldt Moonglow Raiiisgate COIJ2!. A-II GOMI. A-II OPERATIONfPI^M No. Cen 1-43 ANNEX A...Daytona Decatur Delaware Denmark Del Rio Democrat DeSoto Dingbct Dodger Dogwood Dolores Ship or Unit TG 54.1 CTG 54.6 CTF 51 LST 78 Hq

  12. Maatehingute arvu langus osutus suurimaks / Dea Hüvonen

    Index Scriptorium Estoniae

    Hüvonen, Dea

    2007-01-01

    BPE Kinnisvaraeksperdi uuest turuülevaatest selgub, et Eesti majanduskasvu aeglustumine on mõjutanud kinnisvarasektorit. Diagramm: Elamumaa hinnad Tallinnas ning lähiomavalitsustes 2006. a I kv - 2007. a II kv (keskmine tehinguhind, kr/m2)

  13. 77 FR 55880 - Prudential Short Duration High Yield Fund, Inc. and Prudential Investments LLC; Notice of...

    Science.gov (United States)

    2012-09-11

    ... Fund and has responsibility for the implementation of the Initial Fund's overall investment strategy... disclosure required by condition 2(a)(ii) above, as an exhibit to its next filed Form N-CSR; and (c) The Fund...

  14. 75 FR 62401 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-10-08

    .... Physician, therapeutic, ancillary, and social support services are provided in the participant's residence... and 42 CFR 413.24; Use: In accordance with sections 1815(a), 1833(e), and 1861(v)(A)(ii) of the Social...

  15. Palgaralli aeglustub ja inflatsioon tõuseb / Vello Kutsar

    Index Scriptorium Estoniae

    Kutsar, Vello

    2007-01-01

    2007. aastal kasvas brutokuupalk keskmiselt 20,4 protsenti, järgmisel aastal palgakasv aeglustub ja inflatsioon kasvab, mis mõjutab enim väikesepalgalisi. Joonised: 1. Brutopalk II kvartalis aastatel 2000-2007 (kr) ja selle kasvud protsentides; 2. Keskmine brutopalk maakonniti 2006. ja 2007. a. II kvartalis (kr) ja kasv (%); Tabelid: 1. Keskmine brutokuupalk tegevusalade lõikes 2006. ja 2007. a. II kvartalis (kr) ja kasv protsentides; 2. Rahandusministeeriumi 2007. aasta suvine majandusprognoos

  16. RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility.

    Science.gov (United States)

    Shoji, Tatsuma; Takaya, Akiko; Sato, Yoshiharu; Kimura, Satoshi; Suzuki, Tsutomu; Yamamoto, Tomoko

    2015-10-15

    Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmA(II) enhances binding of telithromycin (TEL) to A752 in Streptococcus pneumoniae. We have found that another intrinsic methylation of the adjacent uridine at position 747 enhances G748 methylation by RlmA(II), rendering TEL susceptibility. U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. Inactivation of RlmCD reduced N1-methylated level of G748 by RlmA(II) in vivo, leading to TEL resistance when the nucleotide A2058, located in domain V of 23S rRNA, was dimethylated by the dimethyltransferase Erm(B). In vitro methylation of rRNA showed that RlmA(II) activity was significantly enhanced by RlmCD-mediated pre-methylation of 23S rRNA. These results suggest that RlmCD-mediated U747 methylation promotes efficient G748 methylation by RlmA(II), thereby facilitating TEL binding to the ribosome. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. Problems of genetic diagnosis: serological markers in the prognosis of the development of human speed abilities

    Directory of Open Access Journals (Sweden)

    Serhiyenko Leonid Prokopovich

    2011-10-01

    Full Text Available The article deals with the study of correlation between blood groups system AB0 and Rh with the peculiarities of the development of human speed abilities. Complex of genetic markers is defined. It is possible to use this complex in the individual prognosis of the development of human motor abilities. With 0(I and A(II blood groups and Rh+ have a high inclination to the physical development. Better identify trends in the phenotypic expression of high-speed abilities in people with 0(I and A(II blood groups in comparison with people with the AB(IV and B(III blood group. The pattern of decreasing susceptibility to the development of high-speed abilities as follows: 0(I>A(II>B(III>AB (IV. It is established that a complex system of genetic markers AB0 and Rh blood has no gender differences.

  18. Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men

    DEFF Research Database (Denmark)

    Ooi, Esther M M; Watts, Gerald F; Chan, Dick C

    2009-01-01

    cholesterol and HDL cholesterol (ptriglyceride, NEFA, insulin, glucose, HOMA score or adiponectin concentrations. Plasma apoM was positively associated with both apoA-I and apoA-II concentrations (r=0.406, p...%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D(3)-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. RESULTS: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL...... apoM and triglycerides were significant, independent predictors of HDL apoA-I FCR (adjusted R(2)=16%, p

  19. 29 CFR 2509.96-1 - Interpretive bulletin relating to participant investment education.

    Science.gov (United States)

    2010-07-01

    ... horizons and risk profiles, where: (i) Such models are based on generally accepted investments theories... 2510.3-21(c) to communications with fiduciaries of participant-directed individual account pension plan... section 3(21)(A)(ii) of ERISA. (3) Asset Allocation Models. Information and materials (e.g., pie charts...

  20. 26 CFR 1.955-1 - Shareholder's pro rata share of amount of previously excluded subpart F income withdrawn from...

    Science.gov (United States)

    2010-04-01

    .... Pursuant to section 951(a)(1)(A)(ii) and the regulations thereunder, a United States shareholder of a... countries at the close of the taxable year, minus (ii) The amount (if any) by which recognized losses on...) The sum of the controlled foreign corporation's earnings and profits (or deficit in earnings and...

  1. Tema 3. Inducción electromagnética (Resumen) (Curso 2010-2011)

    OpenAIRE

    Alvarez, Mariela L.; Beléndez, Augusto; Hernández Prados, Antonio

    2011-01-01

    Resumen del "Tema 3. Inducción electromagnética" de la asignatura Fundamentos Físicos de la Ingeniería II del Grado en Ingeniería en Sonido e Imagen que se imparte en la Escuela Politécnica Superior.

  2. 46 CFR 193.50-5 - Classification.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Classification. 193.50-5 Section 193.50-5 Shipping COAST... Details § 193.50-5 Classification. (a) Hand portable fire extinguishers and semiportable fire...) Classification Type Size Soda-acid and water, gals. Foam, gals. Carbon dioxide, lbs. Dry chemical, lbs. A II 21/2...

  3. Parameter Estimation for the Blind Restoration of Blurred Imagery.

    Science.gov (United States)

    1986-09-01

    4 Ii. Image Restoration Theory . ............. 5 Linear Space Invariant Systems.... .... 5 Imaging System .. ............ ... 5 Image Restoration...transformation and inversion, and image file input/output. - o A IiI. Image Restoration Theory Linear Space Invariant Systems We can think of a system as a

  4. 46 CFR 108.495 - Spare charges.

    Science.gov (United States)

    2010-10-01

    ... exit. Stairway and elevator enclosure None required. Corridors A-II 1 in each corridor not more than... propelling machinery spaces B-II 1 for each 1,000 brake horsepower but not less than 2 nor more than 6 in...

  5. 76 FR 78578 - Amendment to the International Traffic in Arms Regulations: Registration and Licensing of Brokers...

    Science.gov (United States)

    2011-12-19

    ..., 22 U.S.C. 2778(b)(1)(A)(ii)). Background The Arms Export Control Act was amended in 1996 (Pub. L. 104... cover certain sensitive defense articles and services (e.g., man- portable air defense systems or... and ultimately identifies a foreign government in Southeast Asia that wishes to procure the defense...

  6. 75 FR 78320 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change, as...

    Science.gov (United States)

    2010-12-15

    ... Complex Order Strategy in Rule 1080.08(a)(ii), but fits better in the definition of Complex Order. \\9...), the Exchange is also revising the definition of Complex Order Strategy, in addition to moving the pricing language, as explained above, to expressly state in the rule that each such strategy is assigned a...

  7. Porphyromonas gingivalis Fim-A genotype distribution among Colombians

    Science.gov (United States)

    Jaramillo, Adriana; Parra, Beatriz; Botero, Javier Enrique; Contreras, Adolfo

    2015-01-01

    Introduction: Porphyromonas gingivalis is associated with periodontitis and exhibit a wide array of virulence factors, including fimbriae which is encoded by the FimA gene representing six known genotypes. Objetive: To identify FimA genotypes of P. gingivalis in subjects from Cali-Colombia, including the co-infection with Aggregatibacter actinomycetemcomitans, Treponema denticola, and Tannerella forsythia. Methods: Subgingival samples were collected from 151 people exhibiting diverse periodontal condition. The occurrence of P. gingivalis, FimA genotypes and other bacteria was determined by PCR. Results: P. gingivalis was positive in 85 patients. Genotype FimA II was more prevalent without reach significant differences among study groups (54.3%), FimA IV was also prevalent in gingivitis (13.0%). A high correlation (p= 0.000) was found among P. gingivalis, T. denticola, and T. forsythia co-infection. The FimA II genotype correlated with concomitant detection of T. denticola and T. forsythia. Conclusions: Porphyromonas gingivalis was high even in the healthy group at the study population. A trend toward a greater frequency of FimA II genotype in patients with moderate and severe periodontitis was determined. The FimA II genotype was also associated with increased pocket depth, greater loss of attachment level, and patients co-infected with T. denticola and T. forsythia. PMID:26600627

  8. 26 CFR 801.3 - Measuring employee performance.

    Science.gov (United States)

    2010-04-01

    ..., will be composed of elements that support the organizational measures of Customer Satisfaction, Employee Satisfaction, and Business Results; however, such organizational measures will not directly...), employee has the meaning as defined in 5 U.S.C. 2105(a). (ii) For purposes of the limitation contained in...

  9. 76 FR 43350 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance and...

    Science.gov (United States)

    2011-07-20

    ... Motivation, Inc., Greenville, OH: June 13, 2010. TA-W-80,236; Unimin Corporation, Green Mountain, NC: June 15... the requirements of 246(a)(3)(A)(ii) have not been met for the reasons specified. The Department has... the eligibility criteria for worker adjustment assistance have not been met for the reasons specified...

  10. 26 CFR 53.4945-3 - Influencing elections and carrying on voter registration drives.

    Science.gov (United States)

    2010-04-01

    ... section 501(c) (3) and exempt from taxation under section 501(a); (ii) The activities of the organization... year and during each preceding taxable year beginning after December 31, 1969. (4) Advance rulings. An organization will be given an advance ruling that it is an organization described in section 4945(f) for its...

  11. 77 FR 68151 - Agency Information Collection Activities; Submission for OMB Review; Comment Request: Main Fan...

    Science.gov (United States)

    2012-11-15

    ... for OMB Review; Comment Request: Main Fan Operation and Inspection (I-A, II-A, III, and V-A Mines... Administration (MSHA) sponsored information collection request (ICR) titled, ``Main Fan Operation and Inspection...: Potentially gassy (explosive) conditions underground are largely controlled by main fans. When accumulations...

  12. 78 FR 74197 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

    Science.gov (United States)

    2013-12-10

    ... proposed rule change as described in Items I, II and III below, which Items have been prepared by the self... definitions section of the General and Floor Rules of the NYSE MKT Equities Rules, and ATP Holders, as that... defined in Rule 123B.30(a)(ii)(B)-- Equities and NYSE Amex Options Rule 900.2NY(77); and (iii) non- member...

  13. 40 CFR 721.185 - Limitation or revocation of certain notification requirements.

    Science.gov (United States)

    2010-07-01

    ... reexamined the test data or other information or analysis supporting its decision to add the substance to... its finding under section 5(e)(1)(A)(ii)(I) of the Act, and has concluded that a rational basis no... affected person may request modification or revocation of significant new use notification requirements for...

  14. 75 FR 46847 - Halosulfuron-methyl; Pesticide Tolerances

    Science.gov (United States)

    2010-08-04

    ...; vegetables, tuberous and corm, subgroup 1C; bushberry, subgroup 13-07B; apple; rhubarb; and okra at 0.05 ppm... food) only if EPA determines that the tolerance is ``safe.'' Section 408(b)(2)(A)(ii) of FFDCA defines ``safe'' to mean that ``there is a reasonable certainty that no harm will result from aggregate exposure...

  15. 26 CFR 301.6104(a)-2 - Public inspection of material relating to pension and other plans.

    Science.gov (United States)

    2010-04-01

    ... pension and other plans. 301.6104(a)-2 Section 301.6104(a)-2 Internal Revenue INTERNAL REVENUE SERVICE... and Returns Returns and Records § 301.6104(a)-2 Public inspection of material relating to pension and...— (i) A pension, profit-sharing, or stock bonus plan under section 401(a), (ii) An annuity plan under...

  16. 77 FR 26052 - Invesco Total Property Market Income Fund, et al.; Notice of Application

    Science.gov (United States)

    2012-05-02

    ... level of current income. It is currently contemplated that the common shares of the Property Fund and... disclosure required by condition 2(a)(ii) above, as an exhibit to its next filed Form N-CSR; and (c) The Fund...

  17. 26 CFR 1.956-1T - Shareholder's pro rata share of a controlled foreign corporation's increase in earnings invested...

    Science.gov (United States)

    2010-04-01

    ... exchange for $10x of CFC stock and $90x cash. US2's transfer of its stock to CFC is described in section 351, US2 recognizes no gain in the exchange under section 1032(a), and CFC's basis in the US2 stock acquired in the exchange is determined under section 362(a). (ii) Analysis. The US2 stock acquired by CFC...

  18. 26 CFR 305.7871-1 - Indian tribal governments treated as States for certain purposes.

    Science.gov (United States)

    2010-04-01

    ... for taxes); (3) Section 511(a)(2)(B) (relating to the taxation of colleges and universities which are... scholarships and fellowship grants); (7) Section 403(b)(1)(A)(ii) (relating to the taxation of contributions of... transaction involves the exercise of an essential governmental function of the Indian tribal government, as...

  19. 33 CFR 385.5 - Guidance memoranda.

    Science.gov (United States)

    2010-07-01

    ... ability of the Corps of Engineers, the South Florida Water Management District, and other non-Federal... § 385.5 Guidance memoranda. (a) General. (1) Technical guidance for internal management of Corps of...) General format and content of Project Implementation Reports (§ 385.26(a)); (ii) Instructions for...

  20. 40 CFR 63.8000 - What are my general requirements for complying with this subpart?

    Science.gov (United States)

    2010-07-01

    ...) [Reserved] (ii) You must determine the calibration gases and reporting units for TOC CEMS in accordance with... maintenance activities are being performed. An operating block is a period of time from the beginning to end... all maintenance performed on the CPMS as specified in § 63.998(c)(1)(ii)(A). (ii) When subpart SS of...

  1. 21 CFR 801.420 - Hearing aid devices; professional and patient labeling.

    Science.gov (United States)

    2010-04-01

    ...) Maintenance and care of the hearing aid, including the procedure to follow in washing the earmold, when... with a physician, e.g., skin irritation and accelerated accumulation of cerumen (ear wax). (viii) A.... (ii) History of active drainage from the ear within the previous 90 days. (iii) History of sudden or...

  2. 37 CFR 1.555 - Information material to patentability in ex parte reexamination and inter partes reexamination...

    Science.gov (United States)

    2010-07-01

    ... publications, a prima facie case of unpatentability of a claim; or (2) It refutes, or is inconsistent with, a... (ii) Asserting an argument of patentability. A prima facie case of unpatentability of a claim pending... duty of candor and good faith in dealing with the Office, which includes a duty to disclose to the...

  3. 45 CFR 1355.53 - Conditions for approval of funding.

    Science.gov (United States)

    2010-10-01

    ... title IV-A, (ii) National Child Abuse and Neglect Data Systems (NCANDS), (iii) Systems operated under title XIX, and (iv) Systems operated under title IV-D; (3) Support the provisions of section 422(a) by... system, which is effective and efficient, to improve the program management and administration of the...

  4. Legal action initiated by a municipality in order to prevent installation of a nuclear power station

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    A municipality is authorized to appeal against the licensing of a nuclear power plant which is about to be installed in the neighbourhood of the municipality in order to protect its water treatment plant. (Non-official headnotes) OVG Rheinland-Pfalz, interlocutary decree of June 3, 1986 - 7 A II 2/85 - (appealable). (orig./HSCH) [de

  5. 30 CFR 925.16 - Required program amendments.

    Science.gov (United States)

    2010-07-01

    ... CSR 40-3.240 by providing performance standards that address air quality in a manner no less effective than the Federal regulations at 30 CFR 817.95(a). (5)-(19) [Reserved] (20) At 10 CSR 40-8.070(2)(C)1.A(II)(a) and (b) to revise the definition of cumulative measurement period to provide appropriate dates...

  6. Xanthophylls, phytosterols and pre-β1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study.

    Science.gov (United States)

    Niesor, Eric J; Gauthamadasa, Kekulawalage; Silva, R A Gangani D; Suchankova, Gabriela; Kallend, David; Gylling, Helena; Asztalos, Bela; Damonte, Elisabetta; Rossomanno, Simona; Abt, Markus; Davidson, W Sean; Benghozi, Renee

    2013-12-01

    Fenofibrate and extended-release (ER) niacin similarly raise high-density lipoprotein cholesterol (HDL-C) concentration but their effects on levels of potent plasma antioxidant xanthophylls (lutein and zeaxanthin) and phytosterols obtained from dietary sources, and any relationship with plasma lipoproteins and pre-β1-HDL levels, have not been investigated. We studied these parameters in 66 dyslipidemic patients treated for 6 week with fenofibrate (160 mg/day) or ER-niacin (0.5 g/day for 3 week, then 1 g/day) in a cross-over study. Both treatments increased HDL-C (16 %) and apolipoprotein (apo) A-I (7 %) but only fenofibrate increased apoA-II (28 %). Lutein and zeaxanthin levels were unaffected by fenofibrate but inversely correlated with percentage change in apoB and low-density lipoprotein cholesterol and positively correlated with end of treatment apoA-II. ApoA-II in isolated HDL in vitro bound more lutein than apoA-I. Xanthophylls were increased by ER-niacin (each ~30 %) without any correlation to lipoprotein or apo levels. Only fenofibrate markedly decreased plasma markers of cholesterol absorption; pre-β1-HDL was significantly decreased by fenofibrate (-19 %, p xanthophylls, phytosterols and pre-β1-HDL differed markedly, suggesting differences in intestinal lipidation of HDL. In addition, the in vitro investigations suggest an important role of plasma apoA-II in xanthophyll metabolism.

  7. 7 CFR 1215.50 - Budget and expenses.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... forth in paragraph (g) of this section; (2) A statement of the objectives and strategy for each program... marketing activities. (f) As stated in section 75(f)(4)(A)(ii) of the Act, the Board shall reimburse the...

  8. 27 CFR 1.60 - Use of distilled spirits.

    Science.gov (United States)

    2010-04-01

    ... educational organization described in 26 U.S.C. 170(b)(1)(A)(ii) which is exempt from income tax under 26 U.S.C. 501(a), or for the use of any scientific university or college of learning; (2) For any...

  9. Increased intra-abdominal fat may lower HDL levels by increasing the fractional catabolic rate of Lp A-I in postmenopausal women.

    Science.gov (United States)

    Vajo, Zoltan; Terry, James G; Brinton, Eliot A

    2002-02-01

    High-density lipoprotein (HDL) particles without apolipoprotein A-II (Lp A-I) may be more anti-atherogenic than HDL with apo A-II (Lp A-I/AII) and Lp A-I is reported selectively to be reduced in cases of intra-abdominal obesity. We explored the mechanisms of this reduction by studying the turnover of Lp A-I and Lp A-I/A-II in postmenopausal women well characterized for total body, regional and sub-regional adiposity by body mass index (BMI), truncal girth ratio, and abdominal magnetic resonance imaging (MRI), respectively. We tested for possible cause-effect relationships by measuring inter-correlations among these variables. Intra-abdominal fat area correlated strongly and positively with the fractional catabolic rate (FCR) of Lp A-I (r=0.98, P=0.003). Intra-abdominal fat only showed a non-significant trend toward correlation with the FCR of Lp A-I/A-II (r=0.84, P=0.07), and had no correlation with the production or transport rate (TR) of either Lp A-I or Lp A-I/A-II (r=0.48 and 0.02, respectively, P>0.1). Subjects were studied both with and without estrogen replacement, allowing exploration of a possible interaction of adiposity with estrogen effects on HDL turnover. Response of HDL turnover to estrogen did not correlate with adiposity, except for a parameter of waist to hip ratio (WHR), which predicted the increase in LP A-I TR with estrogen (r=0.84, P=0.04). We conclude that intra-abdominal fat may lower HDL levels by increasing the FCR of Lp A-I, suggesting a mechanism by which central adiposity may be proatherogenic.

  10. Angiotensin II up-regulates PAX2 oncogene expression and activity in prostate cancer via the angiotensin II type I receptor.

    Science.gov (United States)

    Bose, Sudeep K; Gibson, Willietta; Giri, Shailendra; Nath, Narender; Donald, Carlton D

    2009-09-01

    Paired homeobox 2 gene (PAX2) is a transcriptional regulator, aberrantly expressed in prostate cancer cells and its down-regulation promotes cell death in these cells. The molecular mechanisms of tumor progression by PAX2 over-expression are still unclear. However, it has been reported that angiotensin-II (A-II) induces cell growth in prostate cancer via A-II type 1 receptor (AT1R) and is mediated by the phosphorylation of mitogen activated protein kinase (MAPK) as well as signal transducer and activator of transcription 3 (STAT3). Here we have demonstrated that A-II up-regulates PAX2 expression in prostate epithelial cells and prostate cancer cell lines resulting in increased cell growth. Furthermore, AT1R receptor antagonist losartan was shown to inhibit A-II induced PAX2 expression in prostate cancer. Moreover, analysis using pharmacological inhibitors against MEK1/2, ERK1/2, JAK-II, and phospho-STAT3 demonstrated that AT1R-mediated stimulatory effect of A-II on PAX2 expression was regulated in part by the phosphorylation of ERK1/2, JAK II, and STAT3 pathways. In addition, we have showed that down-regulation of PAX2 by an AT1R antagonist as well as JAK-II and STAT3 inhibitors suppress prostate cancer cell growth. Collectively, these findings show for the first time that the renin-angiotensin system (RAS) may promote prostate tumorigenesis via up-regulation of PAX2 expression. Therefore, PAX2 may be a novel therapeutic target for the treatment of carcinomas such as prostate cancer via the down-regulation of its expression by targeting the AT1R signaling pathways.

  11. A cross-linking study on the particle species of human plasma high density lipoproteins.

    Science.gov (United States)

    Yachida, Y; Minari, O

    1983-08-01

    The present investigation was on the particle species of human plasma high density lipoprotein (HDL) characterized by the stoichiometry of their apoprotein components. HDL2-1, HDL2-2, HDL3-1, and HDL3-2 isolated from normal human plasma by sequential ultracentrifugal flotation were further subfractionated by Bio Gel A-5m gel chromatography or hydroxyapatite column chromatography, and three distinct subfractions were obtained. Subfraction 1 was obtained from all the HDL fractions and it contained mostly apolipoprotein A-I (A-I). Subfraction 2 was obtained from HDL2-2 and HDL3-1 and it contained A-I and apolipoprotein A-II (A-II) in the molar ratio of one to one, and subfraction 3 from HDL2-2 and HDL3-1 contained A-I and apolipoprotein C (C). Each subfraction was treated with bifunctional cross-linking reagents, and the intraparticle cross-linked products of apolipoproteins were examined by SDS-polyacrylamide gel electrophoresis. The results of the cross-linking studies indicated that the HDL2 fraction consisted mainly of lipoprotein particles of the (A-I)4 type and a few of the (A-I)5, (A-I)2(A-II)2, and (A-I)4(C)2 types, and that the HDL3 fraction consisted mainly of (A-I)2(A-II)2 type particles and a few (A-I)4, (A-I)3, (A-I)2, (A-I), and (A-I)3(C)2 type particles. From the results of analyses of the lipid components in the HDL of each type, it was suggested that the function of the particle species of the (A-I)n type (n = 1--5), which contained more cholesteryl ester than the (A-I)2(A-II)2 type, was concerned mainly with cholesterol metabolism.

  12. Chemical Constituents of Piper betle Linn. (Piperaceae Roots

    Directory of Open Access Journals (Sweden)

    T. Bhattacharya

    2005-08-01

    Full Text Available Column chromatography of the alcoholic extract of Piper betle roots furnished aristololactam A-II and a new phenyl propene, characterized as 4-allyl resorcinol, while the petroleum-ether extract yielded a diketosteroid, viz. stigmast-4-en-3,6-dione. All these compounds were characterized by spectroscopic means. Isolation of these compounds from this source is being reported here for the first time.

  13. Chemical constituents of Piper betle Linn. (Piperaceae) roots.

    Science.gov (United States)

    Ghosh, K; Bhattacharya, T K

    2005-08-31

    Column chromatography of the alcoholic extract of Piper betle roots furnished aristololactam A-II and a new phenyl propene, characterized as 4-allyl resorcinol, while the petroleum-ether extract yielded a diketosteroid, viz. stigmast-4-en-3,6-dione. All these compounds were characterized by spectroscopic means. Isolation of these compounds from this source is being reported here for the first time.

  14. A new hydroxychavicol dimer from the roots of Piper betle.

    Science.gov (United States)

    Lin, Chwan-Fwu; Hwang, Tsong-Long; Chien, Chun-Chien; Tu, Huei-Yu; Lay, Horng-Liang

    2013-02-26

    A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

  15. A New Hydroxychavicol Dimer from the Roots of Piper betle

    Directory of Open Access Journals (Sweden)

    Huei-Yu Tu

    2013-02-01

    Full Text Available A new hydroxychavicol dimer, 2-(g'-hydroxychavicol-hydroxychavicol (1, was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2, aristololactam A II (3, aristololactam B II (4, piperolactam A (5 and cepharadione A (6. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

  16. Large-Scale Separation and Wake Closure/Reattachment - The Cascade Problem,

    Science.gov (United States)

    1983-05-01

    7.3b-d) gives, for all x > xsep K (X) = u(u-l)dy + 1se (11-7.7) 44 UTRC83-13 where Isep is the integrated momentum deficit at separation, from (II...with c1 = (K: o 2/b - Isep /b) positive. So (II-7.5a) requires the underlying form -g ~-1/2_ +- g go (G) + x -1()+..+x 2 (a)+ .... (II-7.10a) for g

  17. HMPT: Basic Radioactive Material Transportation

    Energy Technology Data Exchange (ETDEWEB)

    Hypes, Philip A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-29

    Hazardous Materials and Packaging and Transportation (HMPT): Basic Radioactive Material Transportation Live (#30462, suggested one time) and Test (#30463, required initially and every 36 months) address the Department of Transportation’s (DOT’s) function-specific [required for hazardous material (HAZMAT) handlers, packagers, and shippers] training requirements of the HMPT Los Alamos National Laboratory (LANL) Labwide training. This course meets the requirements of 49 CFR 172, Subpart H, Section 172.704(a)(ii), Function-Specific Training.

  18. Annual Scientific Report, Grant AFOSR-81-0205.

    Science.gov (United States)

    1984-12-01

    avoid a ii uber of raditional issues in simulationi: pseudo- randomi niumber generation, " tat istic’al an-alysis or the outputs etc. Methods...scheme is a funCtion of the system state. In this case conflict resolution will be unfair . Fairness equires that the states that obtain when conflicts... eating simultaneously. TIhe drinkers probl’m allows iu’igldmors to drink simultaneously provided t hal t hey are drinkinig froum dilleretit ILot tles

  19. 26 CFR 1.367(b)-1 - Other transfers.

    Science.gov (United States)

    2010-04-01

    ... its successor in interest) that the shareholder is making the election described in § 1.367(b)-3(c)(3... paragraph (c)(2)— (i) A shareholder described in § 1.367(b)-3(b)(1) that realizes income in a transaction described in § 1.367(b)-3(a); (ii) A shareholder that makes the election described in § 1.367(b)-3(c)(3...

  20. The planar algebra associated to a Kac algebra

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Given a Kac algebra H and a II1 factor M, there is a well-known construction of a ... We have attempted to render this paper 'accessible' and self-contained to a person ..... Define Pk(L) to be the vector-space with basis given by the collection of 'k-tangles ..... The assertions (i), (iii) and (iv) are immediate consequences of the ...

  1. Laboratory skinpatches and smart cards based on foils.

    Science.gov (United States)

    Ruano-López, Jesús M; Laouenan, Florian; Agirregabiria, Maria; Rodriguez, Sonia; Krüger, Jan; Flavin, Diarmuid

    2011-01-01

    This paper presents: (i) a hand held system consisting of a portable platform and disposable polymeric Lab-on-a-card capable of performing a nucleic acid concentration, amplification and detection with reagents inside; and a (ii) wearable diagnostic Lab-on-a-Paper skinpatch system, capable of performing in-situ sweat sampling, analyte pre-concentration, and immunoassay analysis. The skinpatch works in conjunction with a hand-held optoelectronic reader / micro PC fluorescence analysis interface.

  2. 77 FR 73937 - Spirodiclofen; Pesticide Tolerances

    Science.gov (United States)

    2012-12-12

    ...-dichlorophenyl)-2-oxo-1- oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate in or on apple, wet pomace and grape..., in or on apple, wet pomace and grape, raisin from 2.0 and 4.0 parts per million (ppm) respectively... EPA determines that the tolerance is ``safe.'' Section 408(b)(2)(A)(ii) of FFDCA defines ``safe'' to...

  3. 78 FR 12803 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-02-25

    ... certainty with respect to execution fees at groups of away options exchanges. Under its flat fee structure...-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule... 240.19b-4. \\3\\ 15 U.S.C. 78s(b)(3)(A)(ii). \\4\\ 17 CFR 240.19b-4(f)(2). I. Self-Regulatory Organization...

  4. Operational Implementation Design for the Earth System Prediction Capability (ESPC): A First-Look

    Science.gov (United States)

    2014-02-20

    developed column model containing 4 bulk soil layers described by their water and ice content and their temperature. The vegetation cover information...time-integration scheme to numerically integrate the governing equations of the physical processes of the soil- vegetation -snowpack medium. Noah has...GRACE-A ii. 5 COSMIC FM1-6 (FM3 has failed) iii. 2 GRAS iv. Terra and TanDEM SAR-X v. CORISS e. IR Sounding Radiances i. IASI ii. AIRS iii

  5. Integrability in the theory of Schroedinger operator and harmonic analysis

    International Nuclear Information System (INIS)

    Chalykh, O.A.; Veselov, A.P.

    1993-01-01

    The algebraic integrability for the Schroedinger equation in R n and the role of the quantum Calogero-Sutherland problem and root systems in this context are discussed. For the special values of the parameters in the potential the explicit formula for the eigenfunction of the corresponding Sutherland operator is found. As an application the explicit formula for the zonal spherical functions on the symmetric spaces SU 2 * n /Sp n (type A II in Cartan notations) is presented. (orig.)

  6. Production site of radiation-induced pulmonary fibrosis

    International Nuclear Information System (INIS)

    Song Liangwen; Cui Xuemei; Gao Yabing; Yang Ruibiao; Xia Guowei; Wang Dewen

    1997-01-01

    Production site development and alterations of early pulmonary fibrosis were studied. Single irradiation was made at right thorax of rats with 0, 15 and 30 Gy of γ-irradiation, respectively. The rats were divided into three groups which were sacrificed 1, 3, 5 months post irradiation. Hydroxyproline in lungs was measured by biochemical method. Pulmonary type I and III collagens were measured by polarization method. Distribution of angiotensin II (A II) in pulmonary tissues was displayed by immunohistochemical method. Extent of pulmonary fibrosis relatively increased with irradiation dose and time elapse after irradiation. Ratio of type I to type III collagens increased with increasing fibrosis. Proliferating collagen fibers mainly came from fibroblasts of pulmonary bronchial and arterial adventitia, and extended into pulmonary parenchyma. Meanwhile, type I collagen substituted for type III collagen in interstitium of pulmonary alveoli. A II was positive for fibroblasts and macrophages in pulmonary interstitium. Irradiation can stimulate fibroblasts in interstitium proliferation, and type I collagen substitutes for type III collagen. Expression and synthesis of A II in interstitium may promote the course of pulmonary fibrosis

  7. Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity.

    Directory of Open Access Journals (Sweden)

    Jinze Qian

    2010-05-01

    Full Text Available Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II deposits as amyloid fibrils (AApoAII and can be transmitted from one animal to another both by the feces and milk excreted by mice with amyloidosis. Thus, mouse AApoAII amyloidosis has been demonstrated to be a "transmissible disease". In this study, to further characterize the transmissibility of amyloidosis, AApoAII amyloid fibrils were injected into transgenic Apoa2(cTg(+/- and normal R1.P1-Apoa2(c mice to induce AApoAII systemic amyloidosis. Two months later, AApoAII amyloid deposits were found in the skeletal muscles of amyloid-affected mice, primarily in the blood vessels and in the interstitial tissues surrounding muscle fibers. When amyloid fibrils extracted from the skeletal muscles were subjected to Western blot analysis, apoA-II was detected. Amyloid fibril fractions isolated from the muscles not only demonstrated the structure of amyloid fibrils but could also induce amyloidosis in young mice depending on its fibril conformation. These findings present a possible pathogenesis of amyloidosis: transmission of amyloid fibril conformation through muscle, and shed new light on the etiology involved in amyloid disorders.

  8. High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy.

    Directory of Open Access Journals (Sweden)

    Laxman Yetukuri

    Full Text Available In a recent FIELD study the fenofibrate therapy surprisingly failed to achieve significant benefit over placebo in the primary endpoint of coronary heart disease events. Increased levels of atherogenic homocysteine were observed in some patients assigned to fenofibrate therapy but the molecular mechanisms behind this are poorly understood. Herein we investigated HDL lipidomic profiles associated with fenofibrate treatment and the drug-induced Hcy levels in the FIELD substudy. We found that fenofibrate leads to complex HDL compositional changes including increased apoA-II, diminishment of lysophosphatidylcholines and increase of sphingomyelins. Ethanolamine plasmalogens were diminished only in a subgroup of fenofibrate-treated patients with elevated homocysteine levels. Finally we performed molecular dynamics simulations to qualitatively reconstitute HDL particles in silico. We found that increased number of apoA-II excludes neutral lipids from HDL surface and apoA-II is more deeply buried in the lipid matrix than apoA-I. In conclusion, a detailed molecular characterization of HDL may provide surrogates for predictors of drug response and thus help identify the patients who might benefit from fenofibrate treatment.

  9. Floodplain Assessment for the Middle Los Alamos Canyon Aggregate Area Investigations in Technical Area 02 at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Hathcock, Charles Dean [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-22

    The proposed action being assessed in this document occurs in TA-02 in the bottom of Los Alamos Canyon. The DOE proposes to conduct soil sampling at AOC 02-011 (d), AOC 02- 011(a)(ii), and SWMU 02-005, and excavate soils in AOC 02-011(a)(ii) as part of a corrective actions effort. Additional shallow surface soil samples (soil grab samples) will be collected throughout the TA-02 area, including within the floodplain, to perform ecotoxicology studies (Figures 1 and 2). The excavation boundaries in AOC 02-011(a)(ii) are slightly within the delineated 100-year floodplain. The project will use a variety of techniques for soil sampling and remediation efforts to include hand/digging, standard hand auger/sampling, excavation using machinery such as backhoe and front end loader and small drill rig. Heavy equipment will traverse the floodplain and spoils piles will be staged in the floodplain within developed or previously disturbed areas (e.g., existing paved roads and parking areas). The project will utilize and maintain appropriate best management practices (BMPs) to contain excavated materials, and all pollutants, including oil from machinery/vehicles. The project will stabilize disturbed areas as appropriate at the end of the project.

  10. ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity

    Science.gov (United States)

    Trotter, Justin H.; Klein, Martin; Jinwal, Umesh K.; Abisambra, Jose F.; Dickey, Chad A.; Tharkur, Jeremy; Masiulis, Irene; Ding, Jindong; Locke, Kirstin G.; Rickman, Catherine Bowes; Birch, David G.; Weeber, Edwin J.; Herz, Joachim

    2011-01-01

    The cellular and molecular mechanisms responsible for the development of inner retinal circuitry are poorly understood. Reelin and apolipoprotein E (apoE), ligands of apoE receptor 2 (ApoER2), are involved in retinal development and degeneration, respectively. Here we describe the function of ApoER2 in the developing and adult retina. ApoER2 expression was highest during postnatal inner retinal synaptic development and was considerably lower in the mature retina. Both during development and in the adult ApoER2 was expressed by A-II amacrine cells. ApoER2 knockout (KO) mice had rod bipolar morphogenic defects, altered A-II amacrine dendritic development, and impaired rod-driven retinal responses. The presence of an intact ApoER2 NPxY motif, necessary for binding disabled-1 (Dab1) and transducing the Reelin signal, was also necessary for development of the rod bipolar pathway while the alternatively-spliced exon19 was not. Mice deficient in another Reelin receptor, very low-density lipoprotein receptor (VLDLR), had normal rod bipolar morphology but altered A-II amacrine dendritic development. VLDLR KO mice also had reductions in oscillatory potentials and delayed synaptic response intervals. Interestingly, age-related reductions in rod and cone function were observed in both ApoER2 and VLDLR KOs. These results support a pivotal role for ApoER2 in the establishment and maintenance of normal retinal synaptic connectivity. PMID:21976526

  11. Characterization of insulin-like growth factor I and insulin receptors on cultured bovine adrenal fasciculata cells. Role of these peptides on adrenal cell function

    International Nuclear Information System (INIS)

    Penhoat, A.; Chatelain, P.G.; Jaillard, C.; Saez, J.M.

    1988-01-01

    We have characterized insulin-like growth factor I (IGF-I) and insulin receptors in cultured bovine adrenal cells by binding and cross-linking affinity experiments. At equilibrium the dissociation constant and the number of binding sites per cell for IGF-I were 1.4 +/- (SE) 0.3 x 10(-9) M and 19,200 +/- 2,100, respectively. Under reduction conditions, disuccinimidyl suberate cross-linked [ 125 I]iodo-IGF-I to one receptor complex with an Mr of 125,000. Adrenal cells also contain specific insulin receptors with an apparent dissociation constant (Kd) of 10(-9) M. Under reduction conditions [ 125 I]iodo-insulin binds to one band with an approximate Mr of 125,000. IGF-I and insulin at micromolar concentrations, but not at nanomolar concentrations, slightly stimulated DNA synthesis, but markedly potentiated the mitogenic action of fibroblast growth factor. Adrenal cells cultured in a serum-free medium containing transferrin, ascorbic acid, and insulin (5 micrograms/ml) maintained fairly constant angiotensin-II (A-II) receptor concentration per cell and increased cAMP release on response to ACTH and their steroidogenic response to both ACTH and A-II. When the cells were cultured in the same medium without insulin, the number of A-II receptors significantly decreased to 65% and the increased responsiveness was blunted. Treatment of such cells for 3 days with increasing concentrations of IGF-I (1-100 ng/ml) produced a 2- to 3-fold increase in A-II receptors and enhanced the cAMP response (3- to 4-fold) to ACTH and the steroidogenic response (4- to 6-fold) to ACTH and A-II. These effects were time and dose dependent (ED50 approximately equal to 10(-9) M). Insulin at micromolar concentrations produced an effect similar to that of IGF-I, but at nanomolar concentrations the effect was far less

  12. Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.

    Science.gov (United States)

    Takaya, Akiko; Sato, Yoshiharu; Shoji, Tatsuma; Yamamoto, Tomoko

    2013-08-01

    Several posttranscriptional modifications of bacterial rRNAs are important in determining antibiotic resistance or sensitivity. In all Gram-positive bacteria, dimethylation of nucleotide A2058, located in domain V of 23S rRNA, by the dimethyltransferase Erm(B) results in low susceptibility and resistance to telithromycin (TEL). However, this is insufficient to produce high-level resistance to TEL in Streptococcus pneumoniae. Inactivation of the methyltransferase RlmA(II), which methylates the N-1 position of nucleotide G748, located in hairpin 35 of domain II of 23S rRNA, results in increased resistance to TEL in erm(B)-carrying S. pneumoniae. Sixteen TEL-resistant mutants (MICs, 16 to 32 μg/ml) were obtained from a clinically isolated S. pneumoniae strain showing low TEL susceptibility (MIC, 2 μg/ml), with mutation resulting in constitutive dimethylation of A2058 because of nucleotide differences in the regulatory region of erm(B) mRNA. Primer extension analysis showed that the degree of methylation at G748 in all TEL-resistant mutants was significantly reduced by a mutation in the gene encoding RlmA(II) to create a stop codon or change an amino acid residue. Furthermore, RNA footprinting with dimethyl sulfate and a molecular modeling study suggested that methylation of G748 may contribute to the stable interaction of TEL with domain II of 23S rRNA, even after dimethylation of A2058 by Erm(B). This novel finding shows that methylation of G748 by RlmA(II) renders S. pneumoniae TEL susceptible.

  13. Influence of Peripheral Artery Disease and Statin Therapy on Apolipoprotein Profiles

    Directory of Open Access Journals (Sweden)

    Andrew W. Gardner

    2013-01-01

    Full Text Available Apolipoprotein B is a stronger predictor of myocardial infarction than LDL cholesterol, and it is inversely related to physical activity and modifiable with exercise training. As such, apolipoprotein measures may be of particular relevance for subjects with PAD and claudication. We compared plasma apolipoprotein profiles in 29 subjects with peripheral artery disease (PAD and intermittent claudication and in 39 control subjects. Furthermore, we compared the plasma apolipoprotein profiles of subjects with PAD either treated (n=17 or untreated (n=12 with statin medications. For the apolipoprotein subparticle analyses, subjects with PAD had higher age-adjusted Lp-B:C (P<0.05 and lower values of Lp-A-I:A-II (P<0.05 than controls. The PAD group taking statins had lower age-adjusted values for apoB (P<0.05, Lp-A-II:B:C:D:E (P<0.05, Lp-B:E + Lp-B:C:E (P<0.05, Lp-B:C (P<0.05, and Lp-A-I (P<0.05 than the untreated PAD group. Subjects with PAD have impaired apolipoprotein profiles than controls, characterized by Lp-B:C and Lp-A-I:A-II. Furthermore, subjects with PAD on statin medications have a more favorable risk profile, particularly noted in multiple apolipoprotein subparticles. The efficacy of statin therapy to improve cardiovascular risk appears more evident in the apolipoprotein sub-particle profile than in the more traditional lipid profile of subjects with PAD and claudication. This trial is registered with ClinicalTrials.gov NCT00618670.

  14. Preliminary analysis of variability in concentration of fine particulate matter - PM1.0, PM2.5 and PM10 in area of Poznań city

    Directory of Open Access Journals (Sweden)

    Sówka Izabela

    2018-01-01

    Full Text Available It is commonly known, that suspended particulate matter pose a threat to human life and health, negatively influence the flora, climate and also materials. Especially dangerous is the presence of high concentration of particulate matter in the area of cities, where density of population is high. The research aimed at determining the variability of suspended particulate matter concentration (PM1.0, PM2.5 and PM10 in two different thermal seasons, in the area of Poznań city. As a part of carried out work we analyzed the variability of concentrations and also performed a preliminary analysis of their correlation. Measured concentrations of particulate matter were contained within following ranges: PM10 – 8.7-69.6 μg/m3, PM2.5 – 2.2-88.5 μg/m3, PM1.0 – 2.5-22.9 μg/m3 in the winter season and 1.0-42.8 μg/m3 (PM10, 1.2-40.3 μg/m3 (PM2.5 and 2.7-10.4 (PM1.0 in the summer season. Preliminary correlative analysis indicated interdependence between the temperature of air, the speed of wind and concentration of particulate matter in selected measurement points. The values of correlation coefficients between the air temperature, speed of wind and concentrations of particulate matter were respectively equal to: for PM10: -0.59 and -0.55 (Jana Pawła II Street, -0.53 and -0.53 (Szymanowskiego Street, for PM2.5: -0.60 and -0.53 (Jana Pawła II Street and for PM1.0 -0.40 and -0.59 (Jana Pawła II Street.

  15. Zucchini yellow mosaic virus: biological properties, detection procedures and comparison of coat protein gene sequences.

    Science.gov (United States)

    Coutts, B A; Kehoe, M A; Webster, C G; Wylie, S J; Jones, R A C

    2011-12-01

    Between 2006 and 2010, 5324 samples from at least 34 weed, two cultivated legume and 11 native species were collected from three cucurbit-growing areas in tropical or subtropical Western Australia. Two new alternative hosts of zucchini yellow mosaic virus (ZYMV) were identified, the Australian native cucurbit Cucumis maderaspatanus, and the naturalised legume species Rhyncosia minima. Low-level (0.7%) seed transmission of ZYMV was found in seedlings grown from seed collected from zucchini (Cucurbita pepo) fruit infected with isolate Cvn-1. Seed transmission was absent in >9500 pumpkin (C. maxima and C. moschata) seedlings from fruit infected with isolate Knx-1. Leaf samples from symptomatic cucurbit plants collected from fields in five cucurbit-growing areas in four Australian states were tested for the presence of ZYMV. When 42 complete coat protein (CP) nucleotide (nt) sequences from the new ZYMV isolates obtained were compared to those of 101 complete CP nt sequences from five other continents, phylogenetic analysis of the 143 ZYMV sequences revealed three distinct groups (A, B and C), with four subgroups in A (I-IV) and two in B (I-II). The new Australian sequences grouped according to collection location, fitting within A-I, A-II and B-II. The 16 new sequences from one isolated location in tropical northern Western Australia all grouped into subgroup B-II, which contained no other isolates. In contrast, the three sequences from the Northern Territory fitted into A-II with 94.6-99.0% nt identities with isolates from the United States, Iran, China and Japan. The 23 new sequences from the central west coast and two east coast locations all fitted into A-I, with 95.9-98.9% nt identities to sequences from Europe and Japan. These findings suggest that (i) there have been at least three separate ZYMV introductions into Australia and (ii) there are few changes to local isolate CP sequences following their establishment in remote growing areas. Isolates from A-I and B

  16. Análise cinemática das ações ofensivas no goalball em situação de jogo : deslocamento do jogador e arremesso

    OpenAIRE

    Thiago Pinguelli Magalhães

    2015-01-01

    Resumo: O goalball é um esporte coletivo praticado por pessoas com deficiência visual e baseado na troca de arremessos entre as equipes, vencendo a equipe que marcar o maior número de gols. Embora o goalball tenha sido criado após a II Guerra, assim como outros esportes paralímpicos, são relativamente escassos estudos da análise do jogo ou das ações dos jogadores nas partidas. Nesse sentido, a videogrametria apresenta-se como uma possiblidade para a análise quantitativa do jogo de maneira mai...

  17. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 6. NDDL Processor Product Specification. Section 3.10.9 through 4.2.

    Science.gov (United States)

    1985-11-01

    132 M1 .2 * 125 ŕ.4 1.6 MICROCOPY RESOLUTION TEST CHART NATKIOAt BUREAU OF STANDARDS 1963-A - -W -o - 4w " " " lE FILE CUBe -. a II j AFVAL-TR-66...a 12- ----- le ------- 37+ - -----21+ - -----90+ 3-1176 I*LL A -A S * - S PS 620141100 1 November 1985 61 ICPYDES I I I I I I... VERRELI I +---+--- 4---+---- ----- f---, IVERENTI IUERRORI IVERRCI +----- 14+ --... 3+ +--+--+ I I I ft--ft---+ I ERRPRO I 3-1196 !V PS 620141100 1

  18. Suicídio na infância e adolescência

    OpenAIRE

    Kuczynski, Evelyn

    2014-01-01

    O presente ensaio é a transcrição da aula ministrada durante a II Jornada sobre Suicídio do Laboratório de Estudos sobre a Morte, ocorrida em 22 de maio de 2013 (Brasil). Propõe-se a abordar aspectos históricos e epidemiológicos do suicídio na infância e na adolescência, além de se concentrar nas abordagens preconizadas para este fenômeno. This essay is the transcription of a class given during the II Workshop on Suicide of ...

  19. Alkane Soluble Transition Metal Complexes.

    Science.gov (United States)

    1983-10-01

    lCam ludoalNm’s W S. has aA F. . Hadley. uppokli *mvahs Capm amAe Hall. 1~i. 6. 08 o.. ILDuataA ulpmr. Cai. 1d. CAM 4. 111aII. lop C Themm. - hftupvtm of...phoahines.3 descrbed previously.’ In this analyuis a series of assumption . isre onadc Our reasons for doing this were twofold. in order to enable a lhoea...nalytical method to be used. It sii be w-me First, pfmospftane complexes have been widely used as be. apparent that the assumptions that must be made

  20. Relation between plasma and brain lipids

    DEFF Research Database (Denmark)

    Wellington, Cheryl L; Frikke-Schmidt, Ruth

    2016-01-01

    : Plasma levels of traditional lipids and lipoproteins are not consistently associated with risk of dementia even though low plasma levels of apolipoprotein E, through unknown mechanisms, robustly predict future dementia. Experimental evidence suggests neuroprotective roles of several brain...... and cerebrospinal fluid apolipoproteins. Whether plasma levels of apolipoprotein E, or any other apolipoprotein with possible central nervous system and/or blood-brain barrier functions (apolipoproteins J, A-I, A-II, A-IV, D, C-I, and C-III) may become accessible biomarker components that improve risk prediction...

  1. Sobre a produção de valor: a recente circulação do poema “Viva Vaia”, de Augusto de Campos

    Directory of Open Access Journals (Sweden)

    Luciana Salazar Salgado

    2016-01-01

    Full Text Available Este artículo propone algunas consideraciones sobre el estatuto del material literario en la contemporaneidad desde un estudio de caso: un poema utilizado como ilustración de material periodístico. Movilizando categorías discursivas, pretende: i contribuir para investigaciones sobre los flujos de texto en cibercultura, y se la entiende como una c ultura hegemónica en el período actual, en la que se complejifica la problemática de la autoría; ii contribuir para el enfoque de los materiales literarios en sus formas de inscripción actuales o actualizadas.

  2. Capítulo II. Marco regulatorio de los contratos internacionales de transferencia de tecnología en los países productores de tecnología

    OpenAIRE

    Guerrero Gaitán, Manuel

    2016-01-01

    I. PLANTEAMIENTO 1. En este capítulo se expone la forma en que se implementan los procesos de transferencia de tecnología en el ámbito internacional con el fin de identificar los problemas que se presentan en estos procesos y que impiden la realización de una correcta transferencia tecnológica. Con este propósito se examina el contrato de licencia como paradigma de los contratos de transferencia de tecnología (II), debido a que los elementos esenciales de este contrato se encuentran presentes...

  3. Aerodynamic Characteristics of Airfoils. Volume 4.

    Science.gov (United States)

    1927-01-01

    8-6-4 -2 02a46 a 10 12 14 16is 20 2Angie of Attack in Degrees. Angle of Attack in Deprese . I~r xi N . A rxi (𔃺\\I ) M ITTll IK’ FORi AERONAUT~ICS RFM...8217 ~ 86--20a2 46 a10 12 14 163826 D Aogle of Attack in Deprese . Angle of it tak in Deprese . A II~ il A CHC ARACTERIISTICS OF Al RFOILS-i V 205 nzmuRRCS

  4. Spatial heterogeneity of biofouling under different cross-flow velocities in reverse osmosis membrane systems

    KAUST Repository

    Farhat, Nadia; Staal, M.; Bucs, Szilard; Van Loosdrecht, M.C.M.; Vrouwenvelder, Johannes S.

    2016-01-01

    the spatial heterogeneity of biofilm development over the membrane fouling simulator (MFS) length (inlet and outlet part) at three different cross-flow velocities (0.08, 0.12 and 0.16 m/s). The MFS contained sheets of membrane and feed spacer and simulatedComparison of the inlet and outlet position of the MFS showed a more (i) heterogeneous biofilm distribution and a (ii) higher biological activity at the inlet side (first 2.5 cm) for all cross-flow velocities. The lowest cross-flow velocity had

  5. Synthesis of Benzimidazole Derivatives: As Anti-hypertensive Agents

    Directory of Open Access Journals (Sweden)

    Jat Rakesh Kumar

    2006-01-01

    Full Text Available A new series of non peptide angiotensin(A-II receptor antagonist has been prepared. This N-(biphenyl methyl imidazoles e.g. 5-substituted (amino -2- phenyl-1-(2ʼcarboxy biphenyl-4-yl benzimidazoles differ from the previously reported and related compounds in that they produce a potent hypertensive effect upon oral administration. The earlier series were generally active only when administered intravenously. It has been found that 2’-position of biphenyl is essential. Only ortho substituted acid possess both high affinity for the AII receptor and oral anti-hypertensive potency.

  6. Bibliography on Cold Regions Science and Technology. Volume 35, Part 2

    Science.gov (United States)

    1981-12-01

    miMures [1480. p.»7-91, rus) 35-1088 Arbazov, \\.A. I sing liquid chlorides in wmtet on slippery loads (1480. p 1 I. 21, ■ us...3,-2*J I sing liquid chlondes in winter on slippery roads [ 1480. p, 11. Ryan, U L Safonova, T.A. ii...volumes, ins, 35-858 Problems of the Vulb. a cmieiit bibllographs , IISII. I»«p.rtls) 35-859 Open pit nulling in aistie regions Elm . S.S

  7. The polarized neutron small-angle scattering instrument at BENSC Berlin

    International Nuclear Information System (INIS)

    Keller, T.; Krist, T.; Danzig, A.; Keiderling, U.; Mezei, F.; Wiedenmann, A.

    2000-01-01

    A polarized neutron beam has been installed at the small-angle neutron-scattering instrument V4 at BENSC Berlin. The main component of this new option is a 1.8 m long cavity transmission polarizer. The advantages of this device compared to the conventional bender polarizers are: (i) high transmission (35% of unpolarized beam at λ=6 A); (ii) the polarization is better than 93% in the wavelength band 4 A 3 O 4 particles embedded in a glass matrix) are presented and compared to a measurement with unpolarized neutrons

  8. Isolation and characterization of human apolipoprotein M-containing lipoproteins

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Nielsen, Lars Bo; Axler, Olof

    2006-01-01

    Apolipoprotein M (apoM) is a novel apolipoprotein with unknown function. In this study, we established a method for isolating apoM-containing lipoproteins and studied their composition and the effect of apoM on HDL function. ApoM-containing lipoproteins were isolated from human plasma...... with immunoaffinity chromatography and compared with lipoproteins lacking apoM. The apoM-containing lipoproteins were predominantly of HDL size; approximately 5% of the total HDL population contained apoM. Mass spectrometry showed that the apoM-containing lipoproteins also contained apoJ, apoA-I, apoA-II, apoC-I, apo...

  9. Impact of angiotensin-converting enzyme gene polymorphism on neurohormonal responses to high- versus low-dose enalapril in advanced heart failure.

    Science.gov (United States)

    Tang, W H Wilson; Vagelos, Randall H; Yee, Yin-Gail; Fowler, Michael B

    2004-11-01

    The impact of angiotensin-converting enzyme (ACE) gene polymorphism on neurohormonal dose response to ACE inhibitor therapy is unclear. ACE Insertion (I) or Deletion (D) genotype was determined in 74 patients with chronic heart failure who were randomly assigned to receive either high-dose or low-dose enalapril over a period of 6 months. Monthly pre-enalapril and post-enalapril neurohormone levels (serum ACE activity (sACE), plasma angiotensin II (A-II), plasma renin activity (PRA), and serum aldosterone (ALDO) were compared between genotype subgroups and between patients who received high- or low-dose enalapril within each genotype subgroup. At baseline, predose/postdose sACE and postdose PRA were significantly higher in the DD genotype. At 6-month follow-up, postdose sACE was reduced in a dose-dependent fashion in all three genotypes (P sACE were consistently higher in the DD genotype when compared with ID or II subgroups. Despite a dose-dependent suppression of sACE, there were no observed statistically significant differences in ALDO and A-II suppression or escape with escalating doses of enalapril within each subgroup.

  10. Significance of radionucleid examination of joints in diagnosis of subclinical arthritis background

    International Nuclear Information System (INIS)

    Andersone, D.; Bulina, I.

    2005-01-01

    Background. A large group of inflammation arthritis is represented by seronegative spondyloarthropathies (SpA), including several nosologies: psoriatic arthritis Bechterev's disease, Reiter's disease, etc. One of the most common SpA forms is Reactive arthritis (ReA). Inflammation process in joints is the most characteristic symptom, which determines severeness, course and prognosis of the disease. One of the most sensitive methods of examination of joints is radionucleid (RN) examination. Increased RNV accumulation in the joints is not a specific feature .for a concrete disease, and growth of its accumulation corresponds to the exudative component of inflammation process which reveals the early stage of joint inflammation (subclinical arthritis). Objectives: To find out how often subclinical inflammation processes (subclinical sinovitis) are observed in patients with minimal systemic activity of ReA. To detect in which joints subclinical sinovitis localizes most commonly. To evaluate significance of radionucleid examinations in diagnosis of subclinical arthritis. Material and methods. RN examination of joints was performed in 41 patient with ReA in I stage of activity and in 35 patients with ReA in II stage of activity, when the causative agent of infection - Chlamydia trachomatis - is localized in the urogenital tract. ReA was diagnosed according to diagnostic criteria of French Rheumatologists Association. For clinical description of joints index was used, characterized by pain intensity during joint palpation, and expressed by gradation degree from 0-3. In 76 patients with ReA I activity degree (ReA I) and ReA II activity degree (ReA II) radionucleid examination was done with marked 99 Tc and analysis of the obtained joint scintigrams for SI area. In the control group, 90 joint scintigrams were analyzed for patients with degenerative joint diseases without palpation pain in the examined joints, determining Tc index (Tc ind) in separate joints and summary Tc ind

  11. Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine

    International Nuclear Information System (INIS)

    Zois, Christos E.; Giatromanolaki, Alexandra; Kainulainen, Heikki; Botaitis, Sotirios; Torvinen, Sira; Simopoulos, Constantinos; Kortsaris, Alexandros; Sivridis, Efthimios; Koukourakis, Michael I.

    2011-01-01

    Research highlights: → We investigated the effect 6 Gy of WBI on the autophagic machinery of normal mouse lung. → Irradiation induces dysfunction of the autophagic machinery in normal lung, characterized by decreased transcription of the LC3A/Beclin-1 mRNA and accumulation of the LC3A, and p62 proteins. → The membrane bound LC3A-II protein levels increased in the cytosolic fraction (not in the pellet), contrasting the patterns noted after starvation-induced autophagy. → Administration of amifostine, reversed all the LC3A and p62 findings, suggesting protection of the normal autophagic function. -- Abstract: Purpose: The effect of ionizing irradiation on the autophagic response of normal tissues is largely unexplored. Abnormal autophagic function may interfere the protein quality control leading to cell degeneration and dysfunction. This study investigates its effect on the autophagic machinery of normal mouse lung. Methods and materials: Mice were exposed to 6 Gy of whole body γ-radiation and sacrificed at various time points. The expression of MAP1LC3A/LC3A/Atg8, beclin-1, p62/sequestosome-1 and of the Bnip3 proteins was analyzed. Results: Following irradiation, the LC3A-I and LC3A-II protein levels increased significantly at 72 h and 7 days. Strikingly, LC3A-II protein was increased (5.6-fold at 7 days; p < 0.001) only in the cytosolic fraction, but remained unchanged in the membrane fraction. The p62 protein, was significantly increased in both supernatant and pellet fraction (p < 0.001), suggesting an autophagosome turnover deregulation. These findings contrast the patterns of starvation-induced autophagy up-regulation. Beclin-1 levels remained unchanged. The Bnip3 protein was significantly increased at 8 h, but it sharply decreased at 72 h (p < 0.05). Administration of amifostine (200 mg/kg), 30 min before irradiation, reversed all the LC3A and p62 findings on blots, suggesting restoration of the normal autophagic function. The LC3A and Beclin1 m

  12. The hand of birds revealed by early ostrich embryos

    Science.gov (United States)

    Feduccia, Alan; Nowicki, Julie

    2002-08-01

    The problem of resolving the homology of the digits of the avian hand has been framed as a conflict between paleontological and embryological evidence, the former thought to support a hand composed of digits I, II, III, because of similarity of the phalangeal formulae of the earliest known bird Archaeopteryx to that of Mesozoic pentadactyl archosaurs, while embryological evidence has traditionally favored a II, III, IV avian hand. We have identified the critical developmental period for the major features of the avian skeleton in a primitive bird, the ostrich. Analysis of digit anlagen in the avian hand has revealed those for digits/metacarpals I and V, thus confirming previous embryological studies that indirectly suggested that the avian hand comprises digits II, III, IV, and was primitively pentadactyl.

  13. Effect of excess supply of heavy metals on the absorption and translocation of iron (/sup 59/Fe) in barley

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, C P; Bisht, S S; Agarwala, S C [Lucknow Univ. (India). Dept. of Botany

    1978-03-01

    The effects of an excess supply of manganese, copper, zinc, cobalt, and nickel on the absorption and translocation of iron tagged with /sup 59/Fe were xamined in 15 days old barley seedlings raised in solution culture. Excess heavy metal treatments and /sup 59/Fe were administered in three different ways: (i) both excess heavy metals and iron supplied through roots- Series A; (ii) excess heavy metal supplied as foliar spray and iron through roots- Series B; and (iii) excess heavy metal supplied through roots and iron as foliar spray-Series C. Results obtained revealed that excess concentrations of manganese, zinc, cobalt, and a to a lesser extent copper interfered with the absorption of iron from the rooting medium, but excess nickel enhanced the absorption and translocation of iron. Thus, unlike other metals, a toxic supply of nickel does not induce iron deficiency.

  14. Extremely Low Frequency (ELF) Communications System Bio-Effects Library Development.

    Science.gov (United States)

    1985-10-01

    44 0 I" " I II - I-I -~i it I it LI S oit ’II La S LLa ..5 I it° it L I itS CD L C La .L- 4.-,, .-.5 c i I- i F6 ’n 1-5 ., , -j -! i h- m. it C...aII a - ma U, a"I o aao a - co 9111 aa "L . ’ * Ia a- I’ c a - ,n a , • lit a w a i a l: * -I a". a aa nC-aa a i Li a IM * a;a -a O~~c acca aZ 31 a a a

  15. Alcaloides bencilisoquinolínicos del tallo de piper augustum rudge

    OpenAIRE

    Delgado A., Wilman; Avella M., Eliseo; P. de Díaz, Aura M.

    2010-01-01

    Del extracto etanólico del tallo de P. augustum Rudge se aislaron: 3beta-hidroxi- 24-etil-delta5.22colestadieno (estigmasterol) I ; l,2-metilendioxi-6-metil-4H-dibenzo(deg) quinolina-4,5(6H)diona (Cepharadione A) II; lactama del ácido lO-amino-3,4- dimetoxifenantreno-1-carboxílico (Cepharanone B) n i y el nuevo compuesto natural: lactama del ácido N-metil-lO-amino- 4-hidroxi-2,3-dimetoxifenantreno-1 –carboxílico IV, Todos los compuestos fueron identificados mediante técnicas espectroscópicas ...

  16. Proceedings of Image Understanding Workshop Held in Palo Alto, California on 23-26 May 1989.

    Science.gov (United States)

    1989-05-01

    CL IO r:it ’A I~ ~ pitrI: iic~i a ii it: I, I I I 7tI I’’e i u r’ xrai ri It oT l Ihri e Q i,i \\iiticr~ ’ar I) r’>ero ~ I t. ..c’ enviro -iments to... iot taco i’ixuil-, itiniaL/at tine .I I’’ ’ I I’’’ itir- smnoothness), constrraint-. itfiitiiar% e ke oclsare petrturpict i11L’ m caniera routatioin...containin buildings. tree cover, and hig~h relief features. because the matching aIuorithms do not "ndertand" the three-dimensional nature of these things

  17. NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS (NESHAP) SUBPART H RADIONUCLIDES POTENTIAL TO EMIT CALCULATIONS

    Energy Technology Data Exchange (ETDEWEB)

    EARLEY JN

    2008-07-23

    This document provides an update of the status of stacks on the Hanford Site and the potential radionuclide emissions, i.e., emissions that could occur with no control devices in place. This review shows the calculations that determined whether the total effective dose equivalent (TEDE) received by the maximum public receptor as a result of potential emissions from any one of these stacks would exceed 0.1 millirem/year. Such stacks require continuous monitoring of the effluent, or other monitoring, to meet the requirements of Washington Administrative code (WAC) 246-247-035(1)(a)(ii) and WAC 246-247-075(1), -(2), and -(6). This revised update reviews the potential-to-emit (PTE) calculations of 31 stacks for Fluor Hanford, Inc. Of those 31 stacks, 11 have the potential to cause a TEDE greater than 0.1 mrem/year.

  18. NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS (NESHAP) SUBPART H; RADIONUCLIDES POTENTIAL-TO-EMIT CALCULATIONS

    International Nuclear Information System (INIS)

    EARLEY JN

    2008-01-01

    This document provides an update of the status of stacks on the Hanford Site and the potential radionuclide emissions, i.e., emissions that could occur with no control devices in place. This review shows the calculations that determined whether the total effective dose equivalent (TEDE) received by the maximum public receptor as a result of potential emissions from any one of these stacks would exceed 0.1 millirem/year. Such stacks require continuous monitoring of the effluent, or other monitoring, to meet the requirements of Washington Administrative code (WAC) 246-247-035(1)(a)(ii) and WAC 246-247-075(1), -(2), and -(6). This revised update reviews the potential-to-emit (PTE) calculations of 31 stacks for Fluor Hanford, Inc. Of those 31 stacks, 11 have the potential to cause a TEDE greater than 0.1 mrem/year

  19. Decoro, engenho e maravilha nos largos e igrejas de Santa Bárbara e Catas Altas Decorum, wit and wonder on villages, squares and churches of Santa Bárbara and Catas Altas (Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo Almeida Bastos

    2011-12-01

    Full Text Available O texto é a base da palestra itinerante que encerrou a II Semana de Música Antiga da UFMG (entre 27/10 e 02/11/2009. A palestra se realizou em visita comentada aos povoados, largos e igrejas de Santa Bárbara e Catas Altas, onde foram analisados aspectos como a implantação no sítio, planta, frontispícios e ornamentação, que conformaram sua formosura, seu engenho e sua maravilha.The text is the basis of the speech that closed the Second Week of Early Music of UFMG. The lecture took place in the shape of commented visits to squares and churches of Santa Barbara and Catas Altas (Brazil, analyzing issues such as eployment of the site, blueprint, façades and ornamentation, which shaped their beauty, their wit and their wonder.

  20. Crystal structure of a dinuclear CoII complex with bridging fluoride ligands: di-μ-fluorido-bis{tris[(6-methylpyridin-2-ylmethyl]amine}dicobalt(II bis(tetrafluoridoborate

    Directory of Open Access Journals (Sweden)

    Masataka Inomata

    2014-11-01

    Full Text Available Reaction of Co(BF42·6H2O with tris[(6-methylpyridin-2-ylmethyl]amiine in methanol results in a fluoride abstraction from BF4−, yielding the unexpected title compound, [Co2F2(C21H24N42](BF42. The complex cation consists of two inversion-related [Co(C21H24N4]2+ moieties bridged by a pair of fluoride ligands. The CoII cation is six-coordinated in a distorted octahedral geometry and forms a +II high-spin state. In the crystal, the complex cation and the BF4− anion are connected by C—H...F hydrogen bonds, forming a three-dimensional network. An intramolecular C—H...F hydrogen bond is also observed.

  1. Absorption lineshape of FA centers in alkali halides

    International Nuclear Information System (INIS)

    Baldacchini, G.; Giovenale, E.; De Matteis, F.; Scacco, A.; Somma, F.; Grassano, U.M.

    1988-01-01

    The line shape of the absorption bands of F A centers in alkali halides have been studied for the first time. The new method used for this investigation is based on the determination of the overlap between the F A1 and F A2 bands from luminescence measurements. The experimental results have been compared with calculated values deduced from the theoretical F A bands of different shapes. For both F A (I) centers in KCl:Na + and F A (II) centers in KCl:Li + and RbCl:Li + the absorption lineshape at low temperature is much closer to a sum of two Lorentzian curves than that of two Gaussian or Poissonian bands. This results shows an unexpected difference with the F centers, whose absorption lineshape is known to be Poissonian at the same temperatures

  2. Os Estados Unidos e a transformação da Ásia

    OpenAIRE

    Gaspar, Carlos

    2008-01-01

    Segundo Nicholas Spykman, os Estados Unidos, não obstante a semelhança da sua posição geográfica em relação à Europa e à Asia, seguiam estratégicas diferentes na sua política europeia e asiática. Esse padrão foi confirmado durante a II Guerra Mundial e na Guerra Fria e parece subsistir no pós-Guerra Fria. Os Estados Unidos consolidaram a sua relação com a Europa através da institucionalização da comunidade transatlântica, mas não existe um quadro multilateral para ordenar as suas relações com...

  3. Time Spent in Indirect Nursing Care

    Science.gov (United States)

    1983-09-01

    unable to recognize what needs to be done, or lacking motivation . Likewise, head nurses may spend too much time giving Cdirect care (14.5%). Perhaps more...of the head nurse time might be redirected to teaching, supervising, and motivating other staff members. Although the objective data are reliable, the...S7 9 1 a NO .06 P4 Z& V- N. 4 1 oe a ~~3 00 0I xI %A II I-~~~- Lai - E, zCk u atII C.p UA a 5 P44 d4. Ps4 .- U)2 co Ili L I ao r40 ey . 1a ,o 01 𔃾K

  4. Situational Determinants of Retention Decisions,

    Science.gov (United States)

    1977-01-01

    ist rd !.-~ ted Omit i., lv I’ ,.- I, - I- fl,vm.’I, ( lol l ‘ t ~ ’ ? I ’ m’ Imut ,,l ~~~ ‘ ‘ h i ’ s ,f..r tug t Ime i t ,iise as represented by a...researc h by ex plu.r ln , ’. tilt’ , - ! I ’ - - Ii, ‘‘1 ‘.11,,.,? m , -, a ,,a Ii ,.‘,mu ,- .. ui C he r.-e,, l Ist m, ’nC ‘I.’r Is lo , , pu n i...I, Tile u s t - I l l C c , vih ,ir-h t imer .’ is ,‘oImnunicat ion aund 1 rmms t ammon~ members nIl 0 wo rK w t ‘ .‘r , I S.’ as l n,m.sp

  5. Pre-adolescentes ("tweens") - desde a perspectiva da teoria piagetana a da psicologia economica

    OpenAIRE

    Maria Aparecida Belintane Fermiano

    2010-01-01

    Resumo: Desde a II Guerra Mundial, os pré-adolescentes passam a ocupar uma nova posição na família e, com o fenômeno da globalização, essa tendência se intensifica. A globalização modifica as relações humanas e novas necessidades são mediadas por simbolismos que provocam desejos e consumo, manipulados pelas estratégias de marketing. Os novos símbolos criados passam a ser constituidores da identidade dos pré-adolescentes ou "tweens", que se encontram vulneráveis, uma vez que não possuem estrat...

  6. ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

    DEFF Research Database (Denmark)

    Alanio, Alexandre; Hauser, Philippe M; Lagrou, Katrien

    2016-01-01

    The Fifth European Conference on Infections in Leukaemia (ECIL-5) convened a meeting to establish evidence-based recommendations for using tests to diagnose Pneumocystis jirovecii pneumonia (PCP) in adult patients with haematological malignancies. Immunofluorescence assays are recommended...... a positive test result may indicate other fungal infections. Genotyping using multilocus sequence markers can be used to investigate suspected outbreaks ( A-II: ). The routine detection of dihydropteroate synthase mutations in cases of treatment failure is not recommended ( B-II: ) since these mutations do...... not affect response to high-dose co-trimoxazole. The clinical utility of these diagnostic tests for the early management of PCP should be further assessed in prospective, randomized interventional studies....

  7. Adjuvant treatment or primary topical monotherapy for ocular surface squamous neoplasia: a systematic review

    Directory of Open Access Journals (Sweden)

    Gustavo Arruda Viani

    Full Text Available ABSTRACT In this systematic review, we evaluated studies involving adjuvant and primary topical treatment for ocular surface squamous neoplasia (OSSN. The findings were: (i adjuvant 5-fluorouracil (5-FU reduces the risk of relapse after surgical excision with mild side effects [level Ib, grade of recommendation (GR A]. (ii Primary topical mitomycin (MMC produces a high rate of complete response, low recurrence rate, and mild side effects (level Ib, GR A. (iii Primary chemotherapy versus adjuvant chemotherapy produce similar rates of recurrence, with no significant difference (level IIb, GR B. (iv Adjuvant 5-FU versus MMC showed no significant differences, with mild side effects in both groups and a better toxicity profile for MMC (level III, GR C. (v Primary topical 5-FU versus MMC versus interferon (IFN showed similar rates of tumor recurrence, mild side effects for all drugs, and more severe side effects in the 5-FU arm, followed successively by MMC and IFN (level III, GR C.

  8. Phylogenetic and genomic characterization of a novel atypical porcine pestivirus in China.

    Science.gov (United States)

    Zhang, H; Wen, W; Hao, G; Hu, Y; Chen, H; Qian, P; Li, X

    2018-02-01

    Atypical porcine pestivirus (APPV) has been considered a novel pestivirus and causative agent of congenital tremor type A-II. An APPV CH-GX2016 strain was characterized from newly born piglets with clinical symptoms of congenital tremor in Guangxi, China. The genome of APPV CH-GX 2016 strain was 11,475 bp in length and encoded a polyprotein composed of the 3,635 amino acids. This genome sequence exhibited 88.0% to 90.8% nucleotide sequence homology with other APPV reference sequences in GenBank. Phylogenetic analysis further showed that APPV CH-GX is a novel pestivirus compared with previously described classical pestivirus strains. Therefore, APPV is present in pigs in China. © 2017 Blackwell Verlag GmbH.

  9. Natural Selection in Virulence Genes of Francisella tularensis.

    Science.gov (United States)

    Gunnell, Mark K; Robison, Richard A; Adams, Byron J

    2016-06-01

    A fundamental tenet of evolution is that alleles that are under negative selection are often deleterious and confer no evolutionary advantage. Negatively selected alleles are removed from the gene pool and are eventually extinguished from the population. Conversely, alleles under positive selection do confer an evolutionary advantage and lead to an increase in the overall fitness of the organism. These alleles increase in frequency until they eventually become fixed in the population. Francisella tularensis is a zoonotic pathogen and a potential biothreat agent. The most virulent type of F. tularensis, Type A, is distributed across North America with Type A.I occurring mainly in the east and Type A.II appearing mainly in the west. F. tularensis is thought to be a genome in decay (losing genes) because of the relatively large number of pseudogenes present in its genome. We hypothesized that the observed frequency of gene loss/pseudogenes may be an artifact of evolution in response to a changing environment, and that genes involved in virulence should be under strong positive selection. To test this hypothesis, we sequenced and compared whole genomes of Type A.I and A.II isolates. We analyzed a subset of virulence and housekeeping genes from several F. tularensis subspecies genomes to ascertain the presence and extent of positive selection. Eleven previously identified virulence genes were screened for positive selection along with 10 housekeeping genes. Analyses of selection yielded one housekeeping gene and 7 virulence genes which showed significant evidence of positive selection at loci implicated in cell surface structures and membrane proteins, metabolism and biosynthesis, transcription, translation and cell separation, and substrate binding and transport. Our results suggest that while the loss of functional genes through disuse could be accelerated by negative selection, the genome decay in Francisella could also be the byproduct of adaptive evolution

  10. Monitoreo del sueño en conductores de ómnibus y camiones: factor relevante a considerar para la renovación de la licencia de conducir Sleep monitoring in bus and truck drivers: relevant factor to consider for the renewal of the driving license

    Directory of Open Access Journals (Sweden)

    Jorge Rey de Castro

    2010-06-01

    Full Text Available La información publicada indica que hasta un tercio de los accidentes de tránsito son producidos por la somnolencia del conductor. El síndrome de apnea-hipopnea del sueño (SAHS es una enfermedad orgánica que causa somnolencia. Puede diagnosticarse por medio de un registro del sueño y controlarse con modalidades terapéuticas distintas y de diferente complejidad según su gravedad, lo que determina el costo final del manejo del SAHS. En los pacientes que emplean disciplinadamente la terapia, los resultados son muy buenos y logran controlar la somnolencia, mejoran la calidad de vida del afectado, protegen su salud y disminuyen ostensiblemente el riesgo de accidentes durante la conducción debido a somnolencia. Ponemos en consideración de las autoridades responsables la aplicación de estas pruebas en choferes con sospecha de SAHS que renuevan licencias de conducir de tipo A-II y A-III.The available information indicates that up to one third of the road traffic accidents are produced by the driver’s sleepiness. Sleep apnea-hypopnea syndrome (SAHS is an organic disease that causes sleepiness. It can be diagnosed by a sleep register and can be controlled by different therapeutic means, varying their complexity according to its severity, which determines the final cost of the management of SAHS. In patients using the therapy thoroughly, the results are very good and achieve to control the sleepiness, improve the quality of life of the affected subject, protect his health and markedly decrease the risk of accidents due to sleepiness during driving. We put into consideration of the respective authorities the application of these tests in drivers suspected of having SAHS who renew their driving licenses type A-II and A-III.

  11. Identification and molecular characterization of Cryptosporidium and Giardia in children and cattle populations from the province of Alava, North of Spain

    Energy Technology Data Exchange (ETDEWEB)

    Cardona, Guillermo A. [Livestock Laboratory, Regional Government of Alava, Ctra. de Azua 4, 01520 Vitoria-Gasteiz (Spain); Carabin, Helene [Department of Biostatistics and Epidemiology, College of Public Health, Oklahoma University Health Sciences Center, 801 Northeast 13th Street, Room 309, Oklahoma City, OK 73104 (United States); Goni, Pilar [Department of Microbiology, Preventive Medicine and Public Health, Faculty of Medicine, University of Zaragoza, Domingo Miral s/n, 50009 Zaragoza (Spain); Arriola, Larraitz [Epidemiology Unit, Public Health Division of Guipuzcoa, Basque Government, Av. Navarra 4, 2013 San Sebastian (Spain); Robinson, Guy [UK Cryptosporidium Reference Unit, Public Health Wales, Microbiology ABM, Swansea, Singleton Hospital, Swansea SA2 8QA (United Kingdom); Fernandez-Crespo, Juan C. [Sub-direction of Public Health of Alava, Department of Health, Basque Government, Avda. Santiago 11, 01002 Vitoria-Gasteiz (Spain); Clavel, Antonio [Department of Microbiology, Preventive Medicine and Public Health, Faculty of Medicine, University of Zaragoza, Domingo Miral s/n, 50009 Zaragoza (Spain); Chalmers, Rachel M. [UK Cryptosporidium Reference Unit, Public Health Wales, Microbiology ABM, Swansea, Singleton Hospital, Swansea SA2 8QA (United Kingdom); Carmena, David, E-mail: d.carmena@imperial.ac.uk [MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN (United Kingdom)

    2011-12-15

    The prevalence of and factors associated with the protozoan enteropathogens Cryptosporidium and Giardia have been investigated in selected children and cattle populations from the province of Alava (Northern Spain). The presence of these organisms was detected in fecal samples using commercially available coproantigen-ELISA (CpAg-ELISA) and immunochromatographic (ICT) assays. A total of 327 caregivers of children participants were asked to answer questions on risk factors potentially associated to the prevalence of Cryptosporidium and Giardia, including water-use practices, water sports and contact with domestic or pet animals. Molecular analyses were conducted using a nested-PCR technique to amplify the small-subunit (SSU) rRNA gene of Cryptosporidium and the triosephosphate isomerase (tpi) gene of Giardia. Cryptosporidium oocysts and Giardia cysts were found in 3 and 16 samples using the CpAg-ELISA, and in 5 and 9 samples using the ICT test, respectively. Cryptosporidium and Giardia were also found in 7 and 17 samples by CpAg-ELISA, and 4 and 14 samples by ICT, respectively, of 227 cattle fecal samples. The overall Cryptosporidium and Giardia infection prevalences, based on a Bayesian approach accounting for the imperfect sensitivities and specificities of both diagnostic tests, were estimated to 1.0% (95% BCI: 0.2%-2.8%) and 3.1% (1.5%-5.3%) in children and 3.0% (0.5%-9.2%) and 1.4% (0.0%-6.4%) in cattle, respectively. In humans, a single Cryptosporidium isolate was characterized as C. hominis. Of seven Giardia isolates, four were identified as assemblage B, two as assemblage A-II and one was a mixed assemblage B + A-II infection. No Cryptosporidium or Giardia isolates could be obtained from cattle samples. Although limited, these results seem to suggest that cattle are unlikely to be an important reservoir of zoonotic Cryptosporidium and/or Giardia in the province of Alava.

  12. Prevalence of fimA genotypes of Porphyromonas gingivalis in adolescent orthodontic patients.

    Directory of Open Access Journals (Sweden)

    Shuang Pan

    Full Text Available The placement of fixed orthodontic appliances may alter the composition of oral microbiota and has the potential risk of periodontal complication. Porphyromonas gingivalis fimbriae play a critical role in colonization of P. gingivalis in subgingival regions. In this study, we investigated the association between the prevalence of P. gingivalis-specific fimA genotypes and periodontal health status in adolescent orthodontic patients, to identify the pathogencity of P. gingivalis during orthodontic therapy.Sixty-one adolescent orthodontic patients were enrolled in the case group, while the control group consisted of 56 periodontally healthy adolescents. At baseline (T0, clinical parameter (gingival index was tested, and subgingival plaque samples were obtained from the lower incisors. The incidences of P. gingivalis and fimA genotypes were detected by polymerase chain reaction. All parameters were reassessed after 1 month (T1, 2 months (T2, 3 months (T3, and 6 months (T4 in the case group and then compared with those of the controls.Both microbiological and clinical parameters from orthodontic patients started to increase after placement of fixed appliances. Maximum values were reached at 3 months after placement and followed by their decreases at six months. However, the microbiological and clinical parameters in the case group were significantly higher than those of the control group. The GI of fimA II, IV-positive samples was significantly higher than that of negative samples.P. gingivalis carrying fimA II or IV was closely related to orthodontic gingivitis. In addition, proper oral hygiene control could lead to little increase in dental plaque accumulation, and exert a beneficial effect to periodontal tissues.

  13. Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors.

    Science.gov (United States)

    Morel, Sophia; Leahy, Jade; Fournier, Maryse; Lamarche, Benoit; Garofalo, Carole; Grimard, Guy; Poulain, Floriane; Delvin, Edgard; Laverdière, Caroline; Krajinovic, Maja; Drouin, Simon; Sinnett, Daniel; Marcil, Valérie; Levy, Emile

    2017-05-01

    Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk of developing late cardiometabolic conditions. However, the mechanisms are not fully understood. This study aimed to characterize the plasma lipid profile, Apo distribution, and lipoprotein composition of 80 childhood ALL survivors compared with 22 healthy controls. Our results show that, despite their young age, 50% of the ALL survivors displayed dyslipidemia, characterized by increased plasma triglyceride (TG) and LDL-cholesterol, as well as decreased HDL-cholesterol. ALL survivors exhibited lower plasma Apo A-I and higher Apo B-100 and C-II levels, along with elevated Apo C-II/C-III and B-100/A-I ratios. VLDL fractions of dyslipidemic ALL survivors contained more TG, free cholesterol, and phospholipid moieties, but less protein. Differences in Apo content were found between ALL survivors and controls for all lipoprotein fractions except HDL 3 HDL 2 , especially, showed reduced Apo A-I and raised Apo A-II, leading to a depressed Apo A-I/A-II ratio. Analysis of VLDL-Apo Cs disclosed a trend for higher Apo C-III 1 content in dyslipidemic ALL survivors. In conclusion, this thorough investigation demonstrates a high prevalence of dyslipidemia in ALL survivors, while highlighting significant abnormalities in their plasma lipid profile and lipoprotein composition. Special attention must, therefore, be paid to these subjects given the atherosclerotic potency of lipid and lipoprotein disorders. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

  14. Long-term monitoring of microsporidia, Cryptosporidium and Giardia infections in western Lowland Gorillas (Gorilla gorilla gorilla) at different stages of habituation in Dzanga Sangha Protected Areas, Central African Republic.

    Science.gov (United States)

    Sak, Bohumil; Petrzelkova, Klara J; Kvetonova, Dana; Mynarova, Anna; Shutt, Kathryn A; Pomajbikova, Katerina; Kalousova, Barbora; Modry, David; Benavides, Julio; Todd, Angelique; Kvac, Martin

    2013-01-01

    Infectious diseases pose one of the greatest threats to endangered species, and a risk of gastrointestinal parasite transmission from humans to wildlife has always been considered as a major concern of tourism. Increased anthropogenic impact on primate populations may result in general changes in communities of their parasites, and also in a direct exchange of parasites between humans and primates. To evaluate the impact of close contact with humans on the occurrence of potentially zoonotic protists in great apes, we conducted a long-term monitoring of microsporidia, Cryptosporidium and Giardia infections in western lowland gorillas at different stages of the habituation process, humans, and other wildlife in Dzanga-Sangha Protected Areas in the Central African Republic. We detected Encephalitozoon cuniculi genotypes I and II (7.5%), Enterocytozoon bieneusi genotype D and three novel genotypes (gorilla 1-3) (4.0%), Giardia intestinalis subgroup A II (2.0%) and Cryptosporidium bovis (0.5%) in gorillas, whereas in humans we found only G. intestinalis subgroup A II (2.1%). In other wild and domestic animals we recorded E. cuniculi genotypes I and II (2.1%), G. intestinalis assemblage E (0.5%) and C. muris TS03 (0.5%). Due to the non-specificity of E. cuniculi genotypes we conclude that detection of the exact source of E. cuniculi infection is problematic. As Giardia intestinalis was recorded primarily in gorilla groups with closer human contact, we suggest that human-gorilla transmission has occurred. We call attention to a potentially negative impact of habituation on selected pathogens which might occur as a result of the more frequent presence of humans in the vicinity of both gorillas under habituation and habituated gorillas, rather than as a consequence of the close contact with humans, which might be a more traditional assumption. We encourage to observe the sections concerning hygiene from the IUCN best practice guidelines for all sites where increased human

  15. Study of apoprotein among atomic bomb survivors

    International Nuclear Information System (INIS)

    Takayama, Sadamatsu; Tokunaga, Yutaka; Ishibashi, Shinzo; Mito, Kazuyo; Ito, Chikako; Kato, Masafumi.

    1988-01-01

    In an effort to examine the relationship between A-bomb exposure and arteriosclerosis, the serum concentrations of apoproteins (Apo) were measured in a total of 192 A-bomb survivors, consisting of 28 A-bomb survivors exposed at ≤2,000 m from the hypocenter (the exposed group) and 110 A-bomb survivors exposed at ≥3,000 m and entering the city 9 days or later after A-bombing (the control group). No definitive difference in average serum concentrations of Apo A-I and A-II was found between the exposed and control groups; nor did average serum concentrations of Apo B and B/A-I differ between the groups. According to the age group, Apo A-I was significantly higher in men over the age of 70 in the exposed group than the control group. Apo B tended to be higher in men over the age of 50 in the exposed group than the control group. As for men in the control group, there was a significant negative correlation between age group and both Apo A-I and A-II; however, this tendency was not seen in the exposed group. For women, no correlation between Apo and age group was found in either the exposed or control group. There was a tendency among men towards a higher incidence of hypoapoproteinemia A-I in the exposed group than the control group. The incidence of hyperapoproteinemia B was significantly higher as well for men in the exposed group than the control group. (Namekawa, K.)

  16. Herança da resistência do Híbrido de Timor UFV 443-03 à ferrugem-do-cafeeiro Inheritance of coffee leaf rust resistance in Timor Hybrid UFV 443-03

    Directory of Open Access Journals (Sweden)

    Alexandre Sandri Capucho

    2009-03-01

    Full Text Available O objetivo deste trabalho foi caracterizar a herança da resistência do Híbrido de Timor UFV 443-03 à ferrugem-do-cafeeiro (Hemileia vastatrix. Para isso, a raça II e o patótipo 001 de ferrugem foram inoculados em 246 plantas da população F2, 115 plantas do retrocruzamento suscetível (RC S e 87 plantas do retrocruzamento resistente (RC R, originadas do cruzamento entre o genótipo suscetível cv. Catuaí Amarelo IAC 64 e a fonte de resistência Híbrido de Timor UFV 443-03. Para ambos os inóculos, a cv. Catuaí Amarelo IAC 64 foi suscetível, enquanto o Híbrido de Timor UFV 443-03, a planta representante da geração F1 e as plantas do RC R foram resistentes. As plantas F2, quando inoculadas com a raça II, apresentaram dois padrões de segregação significativos: 15:1 e 61:3. A herança da resistência foi confirmada pela inoculação das plantas do RC S, que segregaram na proporção de 3:1, padrão esperado para herança condicionada por dois genes. A hipótese de segregação 7:1 para três genes foi rejeitada. Resultados semelhantes foram obtidos para o patótipo 001. Dois genes dominantes e independentes conferem a resistência genética do Híbrido de Timor UFV 443-03 à raça II e ao patótipo 001 de H. vastatrix.The aim of this work was to characterize the resistance inheritance of the Timor Hybrid UFV 443-03 to coffee leaf rust (Hemileia vastatrix. For this, the race II and pathotype 001 of coffee leaf rust were inoculated in 246 F2 plants, 115 susceptible backcrossing (BCS plants, and 87 resistant backcrossing (BC R plants, derived from the crossing between the susceptible genotype 'Catuaí Amarelo' IAC 64 and the resistance source Timor Hybrid UFV 443-03. For both inoculums, the 'Catuaí Amarelo' IAC 64 was susceptible, while the Timor Hybrid, the plant representing F1 generation, and the BC R plants were resistant. The F2 plants inoculated with race II presented two significant segregation ratios: 15:1 and 61:3. The

  17. Validity of Three Recently Proposed Prognostic Grading Indexes for Breast Cancer Patients With Radiosurgically Treated Brain Metastases

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Masaaki, E-mail: BCD06275@nifty.com [Katsuta Hospital Mito GammaHouse, Hitachi-naka (Japan); Department of Neurosurgery, Tokyo Women' s Medical University Medical Center E, Tokyo (Japan); Kawabe, Takuya [Katsuta Hospital Mito GammaHouse, Hitachi-naka (Japan); Department of Neurosurgery, Kyoto Prefectural University of Medicine Graduate School of Medical Sciences, Kyoto (Japan); Higuchi, Yoshinori [Department of Neurosurgery, Chiba University Graduate School of Medicine, Chiba (Japan); Sato, Yasunori [Clinical Research Center, Chiba University Graduate School of Medicine, Chiba (Japan); Barfod, Bierta E. [Katsuta Hospital Mito GammaHouse, Hitachi-naka (Japan); Kasuya, Hidetoshi [Department of Neurosurgery, Tokyo Women' s Medical University Medical Center E, Tokyo (Japan); Urakawa, Yoichi [Katsuta Hospital Mito GammaHouse, Hitachi-naka (Japan)

    2012-12-01

    Purpose: We tested the validity of 3 recently proposed prognostic indexes for breast cancer patients with brain metastases (METs) treated radiosurgically. The 3 indexes are Diagnosis-Specific Graded Prognostic Assessment (DS-GPA), New Breast Cancer (NBC)-Recursive Partitioning Analysis (RPA), and our index, sub-classification of RPA class II patients into 3 sub-classes (RPA class II-a, II-b and II-c) based on Karnofsky performance status, tumor number, original tumor status, and non-brain METs. Methods and Materials: This was an institutional review board-approved, retrospective cohort study using our database of 269 consecutive female breast cancer patients (mean age, 55 years; range, 26-86 years) who underwent Gamma Knife radiosurgery (GKRS) alone, without whole-brain radiation therapy, for brain METs during the 15-year period between 1996 and 2011. The Kaplan-Meier method was used to estimate the absolute risk of each event. Results: Kaplan-Meier plots of our patient series showed statistically significant survival differences among patients stratified into 3, 4, or 5 groups based on the 3 systems (P<.001). However, the mean survival time (MST) differences between some pairs of groups failed to reach statistical significance with all 3 systems. Thus, we attempted to regrade our 269 breast cancer patients into 3 groups by modifying our aforementioned index along with the original RPA class I and III, (ie, RPA I+II-a, II-b, and II-c+III). There were statistically significant MST differences among these 3 groups without overlap of 95% confidence intervals (CIs) between any 2 pairs of groups: 18.4 (95% CI = 14.0-29.5) months in I+II-a, 9.2 in II-b (95% CI = 6.8-12.9, P<.001 vs I+II-a) and 5.0 in II-c+III (95% CI = 4.2-6.8, P<.001 vs II-b). Conclusions: As none of the new grading systems, DS-GPS, BC-RPA and our system, was applicable to our set of radiosurgically treated patients for comparing survivals after GKRS, we slightly modified our system for breast cancer

  18. Controlling the directionality of charge transfer in phthalocyaninato zinc sensitizer for a dye-sensitized solar cell: density functional theory studies.

    Science.gov (United States)

    Wan, Liang; Qi, Dongdong; Zhang, Yuexing; Jiang, Jianzhuang

    2011-01-28

    Density functional theory (DFT) calculation on the molecular structures, charge distribution, molecular orbitals, electronic absorption spectra of a series of eight unsymmetrical phthalocyaninato zinc complexes with one peripheral (E)-2-cyano-3-(5-vinylthiophen-2-yl) acrylic acid substituent at 2 or 3 position as an electron-withdrawing group and a different number of electron-donating amino groups at the remaining peripheral positions (9, 10, 16, 17, 23, 24) of the phthalocyanine ring, namely ZnPc-β-A, ZnPc-β-A-I-NH(2), ZnPc-β-A-II-NH(2), ZnPc-β-A-III-NH(2), ZnPc-β-A-I,II-NH(2), ZnPc-β-A-I,III-NH(2), ZnPc-β-A-II,III-NH(2), and ZnPc-β-A-I,II,III-NH(2), reveals the effects of amino groups on the charge transfer properties of these phthalocyanine derivatives with a typical D-π-A electronic structure. The introduction of amino groups was revealed altering of the atomic charge distribution, lifting the frontier molecular orbital level, red-shift of the near-IR bands in the electronic absorption spectra, and finally resulting in enhanced charge transfer directionality for the phthalocyanine compounds. Along with the increase of the peripheral amino groups at the phthalocyanine ring from 0, 2, 4, to 6, the dihedral angle between the phthalocyanine ring and the average plane of the (E)-2-cyano-3-(5-vinylthiophen-2-yl) acrylic acid substituent increases from 0 to 3.3° in an irregular manner. This is in good contrast to the regular and significant change in the charge distribution, destabilization of frontier orbital energies, and red shift of near-IR bands of phthalocyanine compounds along the same order. In addition, comparative studies indicate the smaller effect of incorporating two amino groups onto the 16 and 17 than on 9 and 10 or 23 and 24 peripheral positions of the phthalocyanine ring onto the aforementioned electronic properties, suggesting the least effect on tuning the charge transfer property of the phthalocyanine compound via introducing two

  19. Interrelationships between postprandial lipoprotein B:CIII particle changes and high-density lipoprotein subpopulation profiles in mixed hyperlipoproteinemia.

    Science.gov (United States)

    Saïdi, Y; Sich, D; Camproux, A; Egloff, M; Federspiel, M C; Gautier, V; Raisonnier, A; Turpin, G; Beucler, I

    1999-01-01

    We studied the relationships postprandially between triglyceride-rich lipoprotein (TRL) and high-density lipoprotein (HDL) in 11 mixed hyperlipoproteinemia (MHL) and 11 hypercholesterolemia (HCL) patients. The high and prolonged postprandial triglyceridemia response observed in MHL but not HCL patients was essentially dependent on very-low-density lipoprotein (VLDL) changes. This abnormal response was related to decreased lipoprotein lipase (LPL) activity (-48.7%, P<.01) in MHL compared with HCL subjects. Cholesteryl ester transfer protein (CETP) activity was postprandially enhanced only in MHL patients, and this elevation persisted in the late period (+19% at 12 hours, P<.05), sustaining the delayed enrichment of VLDL with cholesteryl ester (CE). The late postprandial period in MHL patients was also characterized by high levels of apolipoprotein B (apoB)-containing lipoproteins with apoCIII ([LpB:CIII] +36% at 12 hours, P<.01) and decreased levels of apoCIII contained in HDL ([LpCIII-HDL] -34% at 12 hours, P<.01), reflecting probably a defective return of apoCIII from TRL toward HDL. In MHL compared with HCL patients, decreased HDL2 levels were related to both HDL2b and HDL2a subpopulations (-57% and -49%, respectively, P<.01 for both) and decreased apoA-I levels (-53%, P<.01) were equally linked to decreased HDL2 with apoA-I only (LpA-I) and HDL2 with both apoA-I and apoA-II ([LpA-I:A-II] -55% and -52%, respectively, P<.01 for both). The significant inverse correlations between the postprandial magnitude of LpB:CIII and HDL2-LpA-I and HDL2b levels in MHL patients underline the close TRL-HDL interrelationships. Our findings indicate that TRL and HDL abnormalities evidenced at fasting were postprandially amplified, tightly interrelated, and persistent during the late fed period in mixed hyperlipidemia. Thus, these fasting abnormalities are likely postprandially originated and may constitute proatherogenic lipoprotein disorders additional to the HCL in MHL patients.

  20. Long-term monitoring of microsporidia, Cryptosporidium and Giardia infections in western Lowland Gorillas (Gorilla gorilla gorilla at different stages of habituation in Dzanga Sangha Protected Areas, Central African Republic.

    Directory of Open Access Journals (Sweden)

    Bohumil Sak

    Full Text Available BACKGROUND: Infectious diseases pose one of the greatest threats to endangered species, and a risk of gastrointestinal parasite transmission from humans to wildlife has always been considered as a major concern of tourism. Increased anthropogenic impact on primate populations may result in general changes in communities of their parasites, and also in a direct exchange of parasites between humans and primates. AIMS: To evaluate the impact of close contact with humans on the occurrence of potentially zoonotic protists in great apes, we conducted a long-term monitoring of microsporidia, Cryptosporidium and Giardia infections in western lowland gorillas at different stages of the habituation process, humans, and other wildlife in Dzanga-Sangha Protected Areas in the Central African Republic. RESULTS: We detected Encephalitozoon cuniculi genotypes I and II (7.5%, Enterocytozoon bieneusi genotype D and three novel genotypes (gorilla 1-3 (4.0%, Giardia intestinalis subgroup A II (2.0% and Cryptosporidium bovis (0.5% in gorillas, whereas in humans we found only G. intestinalis subgroup A II (2.1%. In other wild and domestic animals we recorded E. cuniculi genotypes I and II (2.1%, G. intestinalis assemblage E (0.5% and C. muris TS03 (0.5%. CONCLUSION: Due to the non-specificity of E. cuniculi genotypes we conclude that detection of the exact source of E. cuniculi infection is problematic. As Giardia intestinalis was recorded primarily in gorilla groups with closer human contact, we suggest that human-gorilla transmission has occurred. We call attention to a potentially negative impact of habituation on selected pathogens which might occur as a result of the more frequent presence of humans in the vicinity of both gorillas under habituation and habituated gorillas, rather than as a consequence of the close contact with humans, which might be a more traditional assumption. We encourage to observe the sections concerning hygiene from the IUCN best

  1. Identification and molecular characterization of Cryptosporidium and Giardia in children and cattle populations from the province of Álava, North of Spain

    International Nuclear Information System (INIS)

    Cardona, Guillermo A.; Carabin, Hélène; Goñi, Pilar; Arriola, Larraitz; Robinson, Guy; Fernández-Crespo, Juan C.; Clavel, Antonio; Chalmers, Rachel M.; Carmena, David

    2011-01-01

    The prevalence of and factors associated with the protozoan enteropathogens Cryptosporidium and Giardia have been investigated in selected children and cattle populations from the province of Álava (Northern Spain). The presence of these organisms was detected in fecal samples using commercially available coproantigen-ELISA (CpAg-ELISA) and immunochromatographic (ICT) assays. A total of 327 caregivers of children participants were asked to answer questions on risk factors potentially associated to the prevalence of Cryptosporidium and Giardia, including water-use practices, water sports and contact with domestic or pet animals. Molecular analyses were conducted using a nested-PCR technique to amplify the small-subunit (SSU) rRNA gene of Cryptosporidium and the triosephosphate isomerase (tpi) gene of Giardia. Cryptosporidium oocysts and Giardia cysts were found in 3 and 16 samples using the CpAg-ELISA, and in 5 and 9 samples using the ICT test, respectively. Cryptosporidium and Giardia were also found in 7 and 17 samples by CpAg-ELISA, and 4 and 14 samples by ICT, respectively, of 227 cattle fecal samples. The overall Cryptosporidium and Giardia infection prevalences, based on a Bayesian approach accounting for the imperfect sensitivities and specificities of both diagnostic tests, were estimated to 1.0% (95% BCI: 0.2%–2.8%) and 3.1% (1.5%–5.3%) in children and 3.0% (0.5%–9.2%) and 1.4% (0.0%–6.4%) in cattle, respectively. In humans, a single Cryptosporidium isolate was characterized as C. hominis. Of seven Giardia isolates, four were identified as assemblage B, two as assemblage A-II and one was a mixed assemblage B + A-II infection. No Cryptosporidium or Giardia isolates could be obtained from cattle samples. Although limited, these results seem to suggest that cattle are unlikely to be an important reservoir of zoonotic Cryptosporidium and/or Giardia in the province of Álava.

  2. Temporal and spatial spectroscopy of the plasma formation in crossed electric and magnetic fields

    International Nuclear Information System (INIS)

    Miljevic, V.I.; Tosic, D.D.

    1980-01-01

    The formation of argon plasma in crossed electric and magnetic fields in a cylindrical diode with an incandescent cathode has been studied by means of the delay time of the anode current pulse and photon pulse (corresponding to the optical transitions) and the shape of the voltage collapse. The working conditions were: pressure p=10 -5 --10 -3 Torr, anode voltage U/sub a/=800 V, and maximum magnetic field B/sub max/=1200 Gs. Photoelectrical recording of spectral lines was performed with a monochromator in the wavelength range 3600--6000 A, and the total optical spectrum was recorded simultaneously on a photoplate in a separate spectrograph in the wavelength range 2000--10 000 A. The delay time of the anode current pulse and photon pulse are approximately the same and are in the millisecond range. The delay time of the photon pulse does not depend on the wavelength. Simultaneously the spectral lines of the working gas (A II), residual gas (O II), and tungsten (W I) appear. Tungsten atoms appear at the moment of breakdown as a result of ion bombardment of the cathode. Neutral atomic lines of the working gas (A I) have not been observed. Radial analysis shows that the delay time of the photon pulse does not depend on the radius. Spectroscopic results have been analyzed in terms of excitation and ionization processes during the formation time. The shape of the voltage collapse suggests the streamer breakdown mechanism

  3. Tracing the evolution of avian wing digits.

    Science.gov (United States)

    Xu, Xing; Mackem, Susan

    2013-06-17

    It is widely accepted that birds are a subgroup of dinosaurs, but there is an apparent conflict: modern birds have been thought to possess only the middle three fingers (digits II-III-IV) of an idealized five-digit tetrapod hand based on embryological data, but their Mesozoic tetanuran dinosaur ancestors are considered to have the first three digits (I-II-III) based on fossil evidence. How could such an evolutionary quirk arise? Various hypotheses have been proposed to resolve this paradox. Adding to the confusion, some recent developmental studies support a I-II-III designation for avian wing digits whereas some recent paleontological data are consistent with a II-III-IV identification of the Mesozoic tetanuran digits. A comprehensive analysis of both paleontological and developmental data suggests that the evolution of the avian wing digits may have been driven by homeotic transformations of digit identity, which are more likely to have occurred in a partial and piecemeal manner. Additionally, recent genetic studies in mouse models showing plausible mechanisms for central digit loss invite consideration of new alternative possibilities (I-II-IV or I-III-IV) for the homologies of avian wing digits. While much progress has been made, some advances point to the complexity of the problem and a final resolution to this ongoing debate demands additional work from both paleontological and developmental perspectives, which will surely yield new insights on mechanisms of evolutionary adaptation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Shield design of concrete wall between decay tank room and primary pump room in TRIGA facility

    International Nuclear Information System (INIS)

    Khan, M. J. H.; Rahman, M.; Haque, A.; Zulquarnain, A.; Ahmed, F. U.; Bhuiyan, S. I.

    2007-01-01

    The objective of this study is to recommend the radiation protection design parameters from the shielding point of view for concrete wall between the decay tank room and the primary pump room in TRIGA Mark-II research reactor facility. The shield design for this concrete wall has been performed with the help of Point-kernel Shielding Code Micro-Shield 5.05 and this design was also validated based on the measured dose rate values with Radiation Survey Meter (G-M Counter) considering the ICRP-60 (1990) recommendations for occupational dose rate limit (10 μSv/hr). The recommended shield design parameters are: (i) thickness of 114.3 cm Ilmenite-Magnetite Concrete (IMC) or 129.54 cm Ordinary Reinforced Concrete (ORC) for concrete wall A (ii) thickness of 66.04 cm Ilmenite-Magnetite Concrete (IMC) or 78.74 cm Ordinary Reinforced Concrete (ORC) for concrete wall B and (iii) door thickness of 3.175 cm Mild Steel (MS) on the entrance of decay tank room. In shielding efficiency analysis, the use of I-M concrete in the design of this concrete wall shows that it reduced the dose rate by a factor of at least 3.52 times approximately compared to ordinary reinforced concrete

  5. Adaptação da “The Resilience Scale” para a população adulta portuguesa

    Directory of Open Access Journals (Sweden)

    Cláudia Alexandra Ferreira de Carvalho Ng Deep

    2012-06-01

    Full Text Available Este artigo descreve a adaptação da “The Resilience Scale” para portugueses adultos. Procedeu-se à retradução e validação psicométrica. Fez-se pré-teste e reteste. Obteve-se equivalência linguística/conceptual e validação psicométrica com alpha de Cronbach 0,868 para 23 itens, sugerindo consistência interna. A análise fatorial agrupou 23 variáveis em 4 fatores: I - Perseverança; II - Sentido de vida; III - Serenidade; IV - Autossuficiência e autoconfiança, com valores alpha de Cronbach satisfatórios para cada fator. Verificou-se sensibilidade dos itens através do coeficiente de assimetria e achatamento e comprovou-se a estabilidade temporal. A escala revela boas características psicométricas aferindo níveis de resiliência nesta população.

  6. Genetic diversity in natural populations of Buriti (Mauritia flexuosa L. f.

    Directory of Open Access Journals (Sweden)

    Liene Rocha Picanço Gomes

    2011-01-01

    Full Text Available This study aimed to characterize the genetic diversity of buriti populations by AFLP (Amplified Fragment LengthPolymorphism markers. The analysis was performed in four populations used by traditional communities in the state of Amazonia(Bom Jesus do Anamã, Lauro Sodré, Santa Luzia do Buiçuzinho, and Esperança II. From each population 30 plants wererandomly selected. To obtain the markers four primer combinations were used. The percentage of polymorphic loci was estimated,the molecular variance among and within populations analyzed and a dendrogram constructed. The primers detected 339 polymorphicloci ranging from 81.1 % to 91.1 % among populations. Analysis of molecular variance attributed 77.18 % to variation within and22.8 % to variation between populations. The dendrogram indicated the formation of two groups, showing that the populations ofBom Jesus do Anamã and Lauro Sodré are genetically most similar and thet the genetic and geographical distances are notcorrelated.

  7. High-density lipoprotein apolipoproteins in urine: I. Characterization in normal subjects and in patients with proteinuria.

    Science.gov (United States)

    Gomo, Z A; Henderson, L O; Myrick, J E

    1988-09-01

    A high-resolution two-dimensional electrophoretic method for protein, with silver staining, has been used to characterize and identify urinary high-density-lipoprotein apolipoproteins (HDL-Apos) and their isoforms in healthy subjects and in patients with kidney disease. Analytical techniques based on both molecular mass and ultracentrifugal flotation properties were used to isolate urinary lipoprotein particles with characteristics identical to those of HDL in plasma. HDL-Apos identified in urine of normal subjects and patients with glomerular proteinuria were Apos A-I, A-II, and C. Five isoforms of Apo A-I were present. Immunostaining of electroblotted proteins further confirmed the presence of HDL-Apos in urine. Creatinine clearance rate was decreased in the patients with proteinuria, and ranged from 32.5 to 40 mL/min. Concentrations of cholesterol and triglycerides in serum were greater in the patients' group, whereas mean HDL-cholesterol (0.68, SD 0.10 mmol/L) and Apo A-I (0.953, SD 0.095 g/L) were significantly (each P less than 0.01) lower. Results of this study suggest that measurement of urinary Apo A-I will reflect excretion of HDL in urine.

  8. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Leventhal Bros & Co. Inc. - Martinez A M Construction)

    Science.gov (United States)

    1994-03-01

    70I )I() acca I)(T)1(a0ma (00 0(0m( a)0(0(0(In(T)0)(47)(In0In0a) II I(ON I (nl gn (n (fl I(O 1c 00 00 0c4 i,- . . 0A111 IC0ON II 0 0. Oif l ( N I zo c...M ~ 0if 3:n~ a -Qn~D ODn -4(0r -4~O VDDO UtOMýDCJýfa)nOOOY (4) 1 coo M 000 V) o . 11 W 1 33( 00 t’. II - 4- -- 4 - 4- 44 J4 (IL) I too M 11 Li. 11 f6 ...II.0n C MN ýc NID n c- CV)0 CL -4 4 - N CN N% -4 -. CJ C4-4N en~ to f6 - .- If c 40 0 01. N7 1101 r-ICO00 (n 4 a 110100to I coo 00 Co: E rN . 1

  9. The lion in West Africa is critically endangered.

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    Philipp Henschel

    Full Text Available The African lion has declined to 500 km² PAs and compiled evidence of lion presence/absence for a further eight PAs. All PAs were situated within Lion Conservation Units, geographical units designated as priority lion areas by wildlife experts at a regional lion conservation workshop in 2005. Lions were confirmed in only 4 PAs, and our results suggest that only 406 (273-605 lions remain in West Africa, representing <250 mature individuals. Confirmed lion range is estimated at 49,000 km², or 1.1% of historical range in West Africa. PAs retaining lions were larger than PAs without lions and had significantly higher management budgets. We encourage revision of lion taxonomy, to recognize the genetic distinctiveness of West African lions and highlight their potentially unique conservation value. Further, we call for listing of the lion as critically endangered in West Africa, under criterion C2a(ii for populations with <250 mature individuals. Finally, considering the relative poverty of lion range states in West Africa, we call for urgent mobilization of investment from the international community to assist range states to increase management effectiveness of PAs retaining lions.

  10. Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry.

    Science.gov (United States)

    Li, Bing; Sheng, Minjie; Xie, Liqi; Liu, Feng; Yan, Guoquan; Wang, Weifang; Lin, Anjuan; Zhao, Fei; Chen, Yihui

    2014-01-09

    Diabetes mellitus has been shown to be associated with and complicated by dry eye syndrome. We sought to examine and compare the tear film proteome of type 2 diabetic patients with or without dry eye syndrome and normal subjects using two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry (MS)-based proteomics. Tears were collected from eight type 2 diabetes patients with dry eye syndrome, eight type 2 diabetes patients without dry eye syndrome, and eight normal subjects. Tear breakup time (BUT) was determined, and tear proteins were prepared and analyzed using two-dimensional strong cation-exchange/reversed-phase nano-scale liquid chromatography MS. All MS/MS spectra were identified by using SEQUEST against the human International Protein Index (IPI) database and the relative abundance of individual proteins was assessed by spectral counting. Tear BUT was significantly lower in patients with diabetes and dry eye syndrome than in patients with diabetes only and normal subjects. Analysis of spectral counts of tear proteins showed that, compared to healthy controls, patients with diabetes and dry eye syndrome had increased expression of apoptosis-related proteins, like annexin A1, and immunity- and inflammation-related proteins, including neutrophil elastase 2 and clusterin, and glycometabolism-related proteins, like apolipoprotein A-II. Dry eye syndrome in diabetic patients is associated with aberrant expression of tear proteins, and the findings could lead to identification of novel pathways for therapeutic targeting and new diagnostic markers.

  11. ALCALOIDES BENCILISOQUINOLÍNICOS DEL TALLO DE Piper augustum Rudge

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    Wilman Delgado A.

    2010-10-01

    Full Text Available Del extracto etanólico del tallo de P. augustum Rudge se aislaron: 3beta-hidroxi- 24-etil-delta5.22colestadieno (estigmasterol I ; l,2-metilendioxi-6-metil-4H-dibenzo(deg quinolina-4,5(6Hdiona (Cepharadione A II; lactama del ácido lO-amino-3,4- dimetoxifenantreno-1-carboxílico (Cepharanone B n i y el nuevo compuesto natural: lactama del ácido N-metil-lO-amino- 4-hidroxi-2,3-dimetoxifenantreno-1 –carboxílico IV, Todos los compuestos fueron identificados mediante técnicas espectroscópicas (EM, RMN 'H y "C, IR y UV y comparación con datos reportados en la literatura; adicionalmente I y II fueron identificados por comparación con muestras auténticas (CCF, pf, y pf, mixto. El extracto etanólico del tallo de Piper augustum Rudge presentó una moderada actividad biológica (DL50 = 350 ppm según el ensayo de mortalidad de Artemia salina Leach (Brine Shrimp Lethality.

  12. Generic procedures for medical response during a nuclear or radiological emergency. Emergency preparedness and response

    International Nuclear Information System (INIS)

    2005-04-01

    The aim of this publication is to serve as a practical resource for planning the medical response to a nuclear or radiological emergency. It fulfils in part functions assigned to the IAEA under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), namely, to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. Effective medical response is a necessary component of the overall response to nuclear or radiological (radiation) emergencies. In general, the medical response may represent a difficult challenge for the authorities due to the complexity of the situation, often requiring specialized expertise, and special organizational arrangements and materials. To be effective, adequate planning and preparedness are needed. This manual, if implemented, should help to contribute to coherent international response. The manual provides the practical tools and generic procedures for use by emergency medical personnel during an emergency situation. It also provides guidance to be used at the stage of preparedness for development of medical response capabilities. The manual also addresses mass casualty emergencies resulting from malicious acts involving radioactive material. This part was supported by the Nuclear Security Fund. The manual was developed based on a number of assumptions about national and local capabilities. Therefore, it must be reviewed and revised as part of the planning process to match the potential accidents, threats, local conditions and other unique characteristics of the facility where it may be used

  13. State-of-the-art of waste wood supply chain in Germany and selected European countries.

    Science.gov (United States)

    Garcia, Carlos A; Hora, Guido

    2017-12-01

    According to the statistic office of the European Union (Eurostat), Germany is the main producer of waste wood in Europe followed by France, United Kingdom, Italy and Finland. Based on the characteristics of the waste wood, it can be classified in four (4) categories: A I, A II, A III and A IV. This paper focuses in the A I waste wood since is the only category able to be used directly for both material and energy purposes without a previously pre-treatment. Currently, most of this waste wood is used for direct energy production due to the previous government legislation that promoted its use directly in incineration facilities. However, the newest Renewable Energy Act (EEG 2017) may promote the cascade-use of A I waste wood prior to be intended for energy purposes. Nonetheless, the government incentives to the energy sector is not the only bottleneck that the use of A I waste wood as raw material in the wood-based industry has to overcome. The peak availability, collection logistics (collection centers and transportation) and recycling facility location are some of the parameters that must be considered in order to design the "best" supply chain network for A I waste wood. This work presents a detailed description of the effect of the hierarchical strategic decision in the proper design of the waste wood supply chain. Additionally, the global picture of waste wood recycling in different European countries (UK, Italy and Finland) is briefly presented. Copyright © 2017. Published by Elsevier Ltd.

  14. Novel aspects of diluted and digital magnetic heterostructures

    International Nuclear Information System (INIS)

    Bonanni, A.

    1999-04-01

    In the present work novel aspects of diluted and digital II-VI-based heterostructures containing Mn ions are investigated. All the structures under study were fabricated by means of molecular beam epitaxy. Digital magnetic heterostructures have been prepared by incorporating discrete (sub)monolayers of the purely magnetic semiconductor MnTe into otherwise non magnetic CdTe quantum wells embedded in CdMgTe barriers. Formation and binding energy of magnetic polarons have been investigated in these structures and compared with the diluted case. Reflectance difference spectroscopy (RDS) performed ex-situ allowed to distinguish between signals due to the crystal anisotropy solely and those induced by the presence a magnetic elements. The problem of p-type doping of bulk diluted magnetic semiconductors II-VI-based is tackled. During and upon growth of ZnMnTe highly doped with N, in-situ RDS was carried out in order to investigate intra-ion transitions within the half filled 3d shell of Mn. Transport measurements and magnetometry at low temperature were performed to study, on the tracks of recent theoretical works, the influence of free carriers on the interaction between magnetic ions. As expected, indications of ferromagnetic ordering were found for the DMS with the highest concentration of carriers. Special attention was given to the formation of Mn islands on a II-VI substrate and to their change in morphology upon overgrowth with a mismatched material. A rich zoology of regularly shaped nanostructures could be produced. (author)

  15. Effects of feeding fatty acid calcium and the interaction of forage quality on production performance and biochemical indexes in early lactation cow.

    Science.gov (United States)

    Hu, Z Y; Yin, Z Y; Lin, X Y; Yan, Z G; Wang, Z H

    2015-10-01

    Multiparous early lactation Holstein cows (n = 16) were used in a randomized complete block design to determine the effects of feeding fatty acid calcium and the interaction of forage quality on production performance and biochemical indexes in early lactation cow. Treatments were as follows: (i) feeding low-quality forage without supplying fatty acid calcium (Diet A), (ii) feeding low-quality forage with supplying 400 g fatty acid calcium (Diet B), (iii) feeding high-quality forage without supplying fatty acid calcium (Diet C) and (iv) feeding high-quality forage with supplying 400 g fatty acid calcium. This experiment consisted 30 days. The milk and blood samples were collected in the last day of the trail. Intakes were recorded in the last 2 days of the trail. Supplementation of fatty acid calcium decreased significantly dry matter intake (DMI) (p < 0.01). Addition fatty acid calcium decreased milk protein percentage (p < 0.01) and milk SNF percentage (p < 0.01), but increased MUN (p < 0.05). Supplemented fatty acid decreased concentration of blood BHBA (p < 0.05), but increased TG, NEFA, glucagon, GLP-1, CCK, leptin, ApoA-IV, serotonin and MSH concentration in blood, the CCK concentration and feed intake showed a significant negative correlation (p < 0.05). Journal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbH.

  16. OPÇÃO PELOS POBRES: LUZ NO ENSINAMENTO SOCIAL DA IGREJA

    Directory of Open Access Journals (Sweden)

    . Editorial

    1988-01-01

    Full Text Available Para comemorar o vigésimo aniversário da Encíclica Populorum Progressio de Paulo VI, o papa João Paulo II escreveu nova encíclica social. Nela pretende retomar e atualizar o ensinamento da encíclica jubilar. A encíclica Populorum Progreçsio, na década de sessenta, colocou- se no caminho aberto pela Mater et Magistra, de João XXIII, quando a Igreja se preocupa, pela primeira vez de maneira explícita, com as desigualdades e o subdesenvolvimento existentes no mundo. O Terceiro Mundo emerge na consciência da Igreja. Esta preocupação estará presente na Constituição Pastoral Gaudium et Spes, do Concilio Vaticano II, e terá a sua formulação mais explícita e lúcida na Populorum Progressio. Daí o impacto que teve citada encíclica, especialmente no Terceiro Mundo e mais especificamente na América Latina. Um ano após a sua publicação realizava-se a II Conferência Episcopal.

  17. GOVERNAMENTALIDADES NEOLIBERAIS E DISPOSITIVOS DE SEGURANÇA

    Directory of Open Access Journals (Sweden)

    Flávia Cristina Silveira Lemos

    2015-08-01

    Full Text Available Este artigo visa a realizar um debate teórico por meio das análises de Michel Foucault e de Robert Castel, entre outros, a respeito dos mecanismos de segurança e das estratégias de governamentalidade neoliberal, na sociedade contemporânea. Os cursos Em defesa da sociedade, Segurança, território e população e Nascimento da Biopolítica, de Foucault, inauguraram uma discussão relevante a respeito dos racismos de Estado e de sociedade, de seus paradoxos, nas democracias, e de seus efeitos a partir da emergência do neoliberalismo norte-americano e alemão, após a II Guerra Mundial, que foram difundidos em outros países, sobretudo na década de noventa do século XX, com especificidades em cada país, mas com pontos de conexão que nos permitem traçar um diagrama da sociedade de segurança e de como ela opera por táticas de governo das condutas, também denominadas governamentalidades, por Foucault.

  18. Errors in measuring absorbed radiation and computing crop radiation use efficiency

    International Nuclear Information System (INIS)

    Gallo, K.P.; Daughtry, C.S.T.; Wiegand, C.L.

    1993-01-01

    Radiation use efficiency (RUE) is often a crucial component of crop growth models that relate dry matter production to energy received by the crop. RUE is a ratio that has units g J -1 , if defined as phytomass per unit of energy received, and units J J -1 , if defined as the energy content of phytomass per unit of energy received. Both the numerator and denominator in computation of RUE can vary with experimental assumptions and methodologies. The objectives of this study were to examine the effect that different methods of measuring the numerator and denominator have on the RUE of corn (Zea mays L.) and to illustrate this variation with experimental data. Computational methods examined included (i) direct measurements of the fraction of photosynthetically active radiation absorbed (f A ), (ii) estimates of f A derived from leaf area index (LAI), and (iii) estimates of f A derived from spectral vegetation indices. Direct measurements of absorbed PAR from planting to physiological maturity of corn were consistently greater than the indirect estimates based on green LAI or the spectral vegetation indices. Consequently, the RUE calculated using directly measured absorbed PAR was lower than the RUE calculated using the indirect measures of absorbed PAR. For crops that contain senesced vegetation, green LAI and the spectral vegetation indices provide appropriate estimates of the fraction of PAR absorbed by a crop canopy and, thus, accurate estimates of crop radiation use efficiency

  19. Potencial evocado auditivo no córtex do bicho preguiça

    Directory of Open Access Journals (Sweden)

    J. Lacaz de Moraes

    1963-12-01

    Full Text Available Foram estudadas as respostas evocadas no córtex do bicho preguiça (Bradypus tridactylus mediante estimulação auditiva, o que permitiu delimitar, abaixo do sulco supra-silviano, duas áreas auditivas (A-I e A-II, com latência para o início da fase positiva de 20 ms (19-25 ms e 30 ms (27-35 ms, respectivamente. Com anestesia barbitúrica profunda, foram obtidas respostas de longa latência (65-110 ms para o início da fase positiva, distribuídas difusamente no córtex, com predominância no pólo anterior do cérebro. Foi estudada a interação de um som contínuo sôbre a resposta evocada em AI, assim como a resistência da resposta evocada em A-I à asfixia. Alguns animais apresentaram resposta evocada em A-I, mesmo após 25 minutos de asfixia.

  20. Cultured human astrocytes secrete large cholesteryl ester- andtriglyceride-rich lipoproteins along with endothelial lipase

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Lin; Liu, Yanzhu; Forte, Trudy M.; Chisholm, Jeffrey W.; Parks, John S.; Shachter, Neil S.

    2003-12-01

    We cultured normal human astrocytes and characterized their secreted lipoproteins. Human astrocytes secreted lipoproteins in the size range of plasma VLDL (Peak 1), LDL (Peak 2), HDL (Peak 3) and a smaller peak (Peak 4), as determined by gel filtration chromatography, nondenaturing gradient gel electrophoresis and transmission electron microscopy. Cholesterol enrichment of astrocytes led to a particular increase in Peak 1. Almost all Peak 2, 3 and 4 cholesterol and most Peak 1 cholesterol was esterified (unlike mouse astrocyte lipoproteins, which exhibited similar peaks but where cholesterol was predominantly non-esterified). Triglycerides were present at about 2/3 the level of cholesterol. LCAT was detected along with two of its activators, apolipoprotein (apo) A-IV and apoC-I. ApoA-I and apoA-II mRNA and protein were absent. ApoJ was present equally in all peaks but apoE was present predominantly in peaks 3 and 4. ApoB was not detected. The electron microscopic appearance of Peak 1 lipoproteins suggested partial lipolysis leading to the detection of a heparin-releasable triglyceride lipase consistent with endothelial lipase. The increased neuronal delivery of lipids from large lipoprotein particles, for which apoE4 has greater affinity than does apoE3, may be a mechanism whereby the apoE {var_epsilon}4 allele contributes to neurodegenerative risk.

  1. Model evaluation of temperature dependency for carbon and nitrogen removal in a full-scale activated sludge plant treating leather-tanning wastewater.

    Science.gov (United States)

    Görgün, Erdem; Insel, Güçlü; Artan, Nazik; Orhon, Derin

    2007-05-01

    Organic carbon and nitrogen removal performance of a full-scale activated sludge plant treating pre-settled leather tanning wastewater was evaluated under dynamic process temperatures. Emphasis was placed upon observed nitrogen removal depicting a highly variable magnitude with changing process temperatures. As the plant was not specifically designed for this purpose, observed nitrogen removal could be largely attributed to simultaneous nitrification and denitrification presumably occurring at increased process temperatures (T>25 degrees C) and resulting low dissolved oxygen levels (DO<0.5 mgO2/L). Model evaluation using long-term data revealed that the yearly performance of activated sludge reactor could be successfully calibrated by means of temperature dependent parameters associated with nitrification, hydrolysis, ammonification and endogenous decay parameters. In this context, the Arrhenius coefficients of (i) for the maximum autotrophic growth rate, [image omitted]A, (ii) maximum hydrolysis rate, khs and (iii) endogenous heterotrophic decay rate, bH were found to be 1.045, 1.070 and 1.035, respectively. The ammonification rate (ka) defining the degradation of soluble organic nitrogen could not be characterized however via an Arrhenius-type equation.

  2. El elixir de la teoría monetaria Argentina: Apuesta por el error tipo ll o una pasión desenfrenada por la inflación

    Directory of Open Access Journals (Sweden)

    Javier Gerardo Milei

    2010-04-01

    Full Text Available Se hace una reseña de las distintas medidas y afirmaciones realizadas por el Gobierno contrastadas con el manual de prácticas en materia de política económica. En función de ello, se presenta una colección de cuatro ensayos: (i El Rol de las Reservas en una Economía, (ii Independencia del BCRA y Tasa de Inflación, (iii La Visión Monetarista de la Inflación y (iv La Inflación, un Fenómeno Siempre Monetario.Se concluye que, en el corto plazo, existe “trade-off” entre inflación y desempleo. Una política monetaria activa ejerce efectos reales sobre el nivel de actividad y empleo. El efecto se diluye luego de 5 años. Finalmente para períodos mayores a diez años no queda efecto en la actividad y se traslada a una mayor inflación. 

  3. Infant feeding practices and its impact on the prevalence of protein energy malnutrition infant feeding practices and its impact on the prevalence of protein energy malnutrition

    Directory of Open Access Journals (Sweden)

    S Nanda

    1995-09-01

    Full Text Available Protein-Energy-Malnulrition is an important Public Hea Ith Problem among infants and young children. Though poverty is known to be the major fac­tor but faulty feeding habits arising out of ignorance often lead to inadequate intake of essential nutrients by the infant. In order to find out the actual prevailing feeding practices and its impact on the nutritional status of infants this study conducted in one urban andtivo rural units of Varanasi district by adopting appropriate sampling procedure. In a II mothers of360 infants (120 in each study un it were interviewed regarding breastfeeding practices, dilution and nature of top milk, age of introducing supplementaryfeeding etc. It was observed that the o verall prevalence of PEM was sig­nificantly higher in bottle fed group (72.73% than spoonfed group (40.11%. Similarly the prevalence of PEM was 67.86% in late weaned group as compared to 48.38% in optimum weaned group.

  4. Tunability of photoswitchable ruthenium sulfoxide compounds on the basis of ligand substitution

    Energy Technology Data Exchange (ETDEWEB)

    Eicke, Sebastian; Dieckmann, Volker; Springfeld, Kristin; Imlau, Mirco [Deparment of Physics, University of Osnabrueck (Germany)

    2010-07-01

    Photoswitchable ruthenium sulfoxide compounds provide a light-induced linkage isomerization in combination with pronounced changes in characteristic optical properties. As representative of the ruthenium sulfoxide group the molecular compound [Ru(bpy){sub 2}(R-OSO)]{sup +} (OSO: 2-methylsulfinylbenzoate) can be tuned in its optical properties by the substitution of the photoswitchable ligands (R=Bn, BnCl, BnMe). These modified sulfoxides were studied in respect to their photochromic properties and kinetics of the generation and relaxation of the light-induced isomers. The kinetics were determined by pump-probe technique and show in each case two reversible thermal decay processes following Arrhenius law. The two photo-excited states offer lifetimes in the magnitude of {tau}{sub 1}{approx}10{sup 3} s and {tau}{sub 2}{approx}10{sup 4} s at room temperature with activation energies about E{sub A,I}=0.72 eV to 0.92 eV and E{sub A,II}=0.8 eV to 1.00 eV. Another respresentative of the photoswitchable sulfoxides is the [Ru(bpy){sub 2}(pySO)]{sup 2+} compound. This molecule is the first sulfoxide which allows for reversible switching between the ground and metastable states by light exposure. With this compound the sulfoxides are highly qualified for optical data storage on a molecular scale.

  5. Cómo aprenden los estudiantes de odontología que cursan el último año de la carrera

    Directory of Open Access Journals (Sweden)

    Licet Álvarez Loureiro

    Full Text Available Objetivos: 1-Conocer las estrategias de aprendizaje utilizadas por los estudiantes de la Facultad de Odontología de la UdelaR que se encontraban cursando Pediatría II en el año 2010. 2- Describir las características de los docentes referidos por los estudiantes como “significativos para su aprendizaje”. Método: Trabajo exploratorio utilizando una encuesta personal, voluntaria, anónima y auto-administrada. Resultados: 79% de los estudiantes estudia solo, por falta de tiempo o por hábito. Dedican entre 2-4 horas diarias. 29% utiliza el manual virtual y 62% utiliza diferentes fuentes. Las prácticas clínicas supervisadas fueron señaladas como facilitadoras del aprendizaje (80% así como las características humanistas del docente Conclusiones: Conocer cómo aprenden los estudiantes permite adaptar la enseñanza y proponer estrategias de mayor autorregulación. Las características más recordadas de los profesores fueron las humanísticas lo cual demuestra el importante rol que desempeñan los docentes en la práctica profesional

  6. Serum amyloid A protein (SAA) from mink, horse, and man: a comparative study

    International Nuclear Information System (INIS)

    Marhaug, G.; Husby, G.; Husebeck, A.; Sletten, K.

    1986-01-01

    Serum amyloid A protein (SAA) was isolated from mink, horse, and human serum by ultracentrifugation and gel filtration and characterized by two-dimensional gel electrophoresis, Western blotting followed by autoradiography and N-terminal amino acid analysis. SAA was found in similar quantities in the high density lipoprotein (HDL) fraction of serum from a patient suffering from systemic juvenile rheumatoid arthritis (JRA) and mink stimulated with lipopolysaccharide (LPS), and in somewhat smaller quantities in serum from horses stimulated with Escherichia coli cultures. Only very small quantities were present in normal human controls and not detectable in normal mink and horse. Striking similarities were found between human and mink SAA with respect to molecular weight, isolectric point and degree of heterogeneity, while the molecular weight, isolectric point and degree of heterogeneity, while the molecular weight of horse SAA seemed to be somewhat lower, and no obvious heterogeneity could be demonstrated in this protein using two-dimensional gel electrophoresis. Immunologic cross-reactivity between SAA from the three species was not found. In contrast to human and horse HDL, mink HDL was found not to contain apoA-II and only minute amounts of apoC proteins. Normal horse HDL also contained additional apoproteins not present in HDL from the other species. N-terminal amino acids analysis of SAA from mink and horse demonstrated the same similarity with the corresponding AA protein as previously reported for human SAA/AA

  7. Generic Procedures for Response to a Nuclear or Radiological Emergency at Research Reactors

    International Nuclear Information System (INIS)

    2011-01-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. The IAEA publishes the Emergency Preparedness and Response Series to fulfil that function. This publication is part of that series. IAEA Safety Standards Series No. GS-R-2 Preparedness and Response for a Nuclear or Radiological Emergency, contains the following requirement: 'To ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene...'. The IAEA General Conference, in resolution GC(53)/RES/10, continues to encourage Member States '...to enhance, where necessary, their own preparedness and response capabilities for nuclear and radiological incidents and emergencies, by improving capabilities to prevent accidents, to respond to emergencies and to mitigate any harmful consequences...'. This publication is intended to assist Member States meet the requirements of GS-R-2 and enhance their preparedness by providing guidance on the response by facility personnel to emergencies at research reactor facilities.

  8. The Effect of Seaweed Eucheuma cottonii on Superoxide Dismutase (SOD Liver of Hypercholesterolemic Rats

    Directory of Open Access Journals (Sweden)

    TUTIK WRESDIYATI

    2008-09-01

    Full Text Available Intracellular antioxidant superoxide dismutase (SOD was reported decreased in the liver and kidney of hypercholesterolemic rats. This study was conducted to observe the effect of seaweed Eucheuma cottonii powder on the profile of blood cholesterol and the level of SOD in liver tissues of hypercholesterolemic rats by using immunohistochemical technique. Twenty male Wistar rats were used for this study. Those rats were divided into four groups; (i negative control group (A, (ii hypercholesterolemia group treated by 5% seaweed powder (B, (iii hypercholesterolemia group treated by 10% seaweed powder (C, and (iv Positive control group or hypercholesterolemia group (D. The experiment was carried out for 35 days. Hypercholesterolemia condition (> 130 mg/dl, except group A, was achieved by feeding the rats with commercial diet containing 1% cholesterol. Drinking water was given ad libitum for 40 days. The results showed that seaweed powder decreased the total cholesterol, low density lipoprotein (LDL, triglyceride, and increased the level of high density lipoprotein (HDL and SOD status in the liver tissues of hypercholesterolemic rats. The treatment of 10% seaweed powder gave better results than that of 5%. These results suggested that dietary fiber such in the seaweed powder has antioxidant activity.

  9. Characterization of lipoproteins from the turtle, Trachemys scripta elegans, in fasted and fed states.

    Science.gov (United States)

    Cain, William; Song, Li; Stephens, Gregory; Usher, David

    2003-04-01

    The lipid and apolipoprotein composition of VLDL, IDL, LDL, HDL(2) and HDL(3) were examined in the turtle, Trachemys scripta elegans, in fasted and fed states. The lipid composition of turtle lipoproteins was very similar to their human counterparts. The major apolipoprotein found in LDL, IDL and VLDL, which has a molecular weight of approximately 550 kD, is a homologue of apoB100. The major apolipoprotein found in both HDL(2) and HDL(3), has a molecular weight of 28-kD and is homologous to human apoA-I. HDL(3) also contains a 6.5 kD protein that is homologous to apoA-II, while HDL(2) has two low molecular weight proteins of 6 kD and 7 kD which are also found on the triglyceride rich lipoproteins (TRL). The 7 kD protein is homologous to apoC-III, while the 6 kD protein has a similar size and distribution as apoC-II or apoC-I. In addition, HDL(2) also possesses a protein of 15.8 kD that has no obvious mammalian homologue. In both size and apolipoprotein composition, turtle HDL(2) resembles human HDL(2b) while turtle HDL(3) resembles human HDL(3). In the fasted state, turtles contained very little TRL. When fed a high fat diet, the amount of IDL and LDL sized particles increased significantly.

  10. Infant Feeding Practices And Its Impact On The Prevalence Of Protein Energy- Malnutrition

    Directory of Open Access Journals (Sweden)

    S Nanda

    1995-09-01

    Full Text Available Protein-Energy-Malnulrition is an important Public Hea Ith Problem among infants and young children. Though poverty is known to be the major fac­tor but faulty feeding habits arising out of ignorance often lead to inadequate intake of essential nutrients by the infant. In order to find out the actual prevailing feeding practices and its impact on the nutritional status of infants this study conducted in one urban andtivo rural units of Varanasi district by adopting appropriate sampling procedure. In a II mothers of360 infants (120 in each study un it were interviewed regarding breastfeeding practices, dilution and nature of top milk, age of introducing supplementaryfeeding etc. It was observed that the o verall prevalence of PEM was sig­nificantly higher in bottle fed group (72.73% than spoonfed group (40.11%. Similarly the prevalence of PEM was 67.86% in late weaned group as compared to 48.38% in optimum weaned group.

  11. Characteristic differences in essential oil composition of six Zanthoxylum bungeanum Maxim. (Rutaceae) cultivars and their biological significance.

    Science.gov (United States)

    Liu, Shu-Ming; Wang, Shi-Jun; Song, Si-Yao; Zou, Yong; Wang, Jun-Ru; Sun, Bing-Yin

    Great variations have been found in composition and content of the essential oil of Zanthoxylum bungeanum Maxim. (Rutaceae), resulting from various factors such as harvest time, drying and extraction methods (Huang et al., 2006; Shao et al., 2013), solvent and herbal parts used (Zhang, 1996; Cao and Zhang, 2010; Wang et al., 2011). However, in terms of artificial introduction and cultivation, there is little research on the chemical composition of essential oil extracted from Z. bungeanum Maxim. cultivars, which have been introduced from different origins. In this study, the composition and content of essential oil from six cultivars (I-VI) have been investigated. They were introduced and cultivated for 11 years in the same cultivation conditions. Cultivars were as followings: Qin'an (I) cultivar originally introduced from Qin'an City in Gansu Province; Dahongpao A (II) from She County in Hebei Province; Dahongpao B (III) from Fuping County; Dahongpao C (IV) from Tongchuan City; Meifengjiao (V) from Feng County; and, Shizitou (VI) from Hancheng City, in Shaanxi Province, China. This research is expected to provide a theoretical basis for further introduction, cultivation, and commercial development of Z. bungeanum Maxim.

  12. Solvent extraction of Zn(II) from aqueous sulphate media by di(2-ethylhexyl) phosphoric acid in kerosene

    International Nuclear Information System (INIS)

    Begum, D.A.; Alauddin, M.; Rahman, M.S.

    2009-01-01

    The extraction equilibrium studies of Zn(II) from sulphate medium by di(2-ethylhexyl) phosphoric acid (D2EHPA, H/sub 2/A/sub 2/) in kerosene revealed that the distribution ratio (D) decreased with the increase of initial (Zn(A(II) in the aqueous phase and increased with the increase of equilibrium pH and extractant concentration. The equilibration is reached within 2 min. The species extracted into the organic phase is thought to be ZnA2, HA. The pH and extractant dependencies were about 2 and 1.67, respectively. The distribution ratio decreased with the increase in sulphate ion concentration in the aqueous phase. The extraction equilibrium reaction is suggested as Zn/sup 2+/ /sub aq/ +1.5 (H/sub 2/A/sub 2/)org - (ZnA/sub 2/, HA)org +2H/sup +/ /sub aq/. The extraction equilibrium constant (kex) for the above reaction was calculated to be 10-2.26. The extraction process was endothermic in nature having positive DH value of 16.27 kJ/mol. The loading of D2EHPA by Zn(II) is about 4.50 g of Zn(II) by 0.10 M D2EHPA. Possible reaction mechanism has been suggested based on distribution data, extractant concentration and equilibrium pH of the aqueous phase. (author)

  13. [The Role of Internet Parenting for the Internet use of Children in Pre-, Primary and Secondary School].

    Science.gov (United States)

    Festl, Ruth; Langmeyer, Alexandra N

    2018-02-01

    The Role of Internet Parenting for the Internet use of Children in Pre-, Primary and Secondary School The present study analyzes the relationship between mothers' and fathers' Internet parenting and children's Internet use across different age groups (1-15 years). Especially, we looked at the influencing factors of parental mediation strategies and the interplay of mothers' and fathers' Internet parenting. Based on data of the DJI-survey "Growing up in Germany" (Aufwachsen in Deutschland: Alltagswelten, AID:A II 2015, N = 1,196), dyadic structural equation models have shown that across all age groups shared parent-child online activities were important influencing factors of regulating the children's Internet use. Also, the self-perceived Internet education competence of mothers and fathers has been confirmed as a relevant factor influencing a more intense use of parental mediation strategies for school-aged children. While the amount of Internet use among young children (1-6 years) was exclusively influenced by features and strategies of mothers' Internet parenting, the transition to elementary school not only marked changes in the frequency of children's Internet use, but also in the ICT parenting of mothers and fathers. For school-aged children, we indeed found an influence of fathers as well as, in case of the oldest age group, a reduced use of parental mediation strategies. However, parents' attitudes, competences and strategies regarding Internet parenting still stayed important during adolescence.

  14. La infraestructura de las tecnologías de la información y comunicación como mediadoras y el aprendizaje de la biología

    Directory of Open Access Journals (Sweden)

    Ramón Acosta

    2014-01-01

    Full Text Available La introducción de la infraestructura de las Tecnologías de la Información y Comunicación (TIC en la didáctica de la biología promueve el aprendizaje de esta ciencia al utilizar una metodología colaborativa y el modelo pedagógico constructivista. El objetivo de esta investigación documental con diseo bibliográfico fue establecer las relaciones entre la infraestructura de las TIC como mediadoras y el aprendizaje de la biología. Las teorías de apoyo para esto fueron: Marqus (2007, Pimienta (2008, Martínez (2008, García (2008, rea (2009, entre otros. El instrumento estuvo materializado por la hoja de registro y el análisis de los datos el de contenido. Conclusiones: i la Infraestructura de las TIC se relacionan con el aprendizaje de la biología, ii la incorporación de las TIC en educación hace que se establezcan nuevos modelos pedagógicos, iii la infraestructura de las TIC capacita a los estudiantes, para la navegación hipertextual y iv en la infraestructura de las TIC se destacan: Webcam, museos virtuales, colecciones biológicas virtuales, microscopía virtual.

  15. Safety related analysis of the application and operation of electrical components in German nuclear power plants, safeguarding and protection against safety relevant impacts from the grid and other external sources; Sicherheitstechnische Analyse zum Einsatz und Betrieb elektrotechnischer Einrichtungen in deutschen Kernkraftwerken, Ueberwachung und Schutz gegen sicherheitstechnisch bedeutsame Einwirkungen aus dem Verbundnetz sowie anderen aeusseren Quellen

    Energy Technology Data Exchange (ETDEWEB)

    Arians, Robert; Arnold, Simone; Blum, Stefanie; Buchholz, Marcel; Lochthofen, Andre; Quester, Claudia; Sommer, Dagmar

    2015-10-15

    In this report, results and data from examinations concerning software-based electrical components and transmitters are evaluated. As failure modes of software-based com-ponents and failure causes differ fundamentally from non-software-based components, an evaluation of the operating experience of such components was carried out. This evaluation should show whether or not existing approaches for non-software-based components can be directly transferred to software-based components, or if a different approach has to be developed. To include failures in non-safety systems, events not fulfilling the incident reporting criteria of German authorities were also included in this evaluation. The data provided by licensees of six German NPPs (different Boiling Wa-ter Reactors and Pressurized Water Reactors) was recorded for at least 8 years. The software-based components used in the NPPs are identified and their operating experience is analyzed in order to identify relevant failure modes and to establish a II knowledge base for future failure rating. In addition, the state of the art and science concerning the specific components was described.

  16. Biological and genetic characterization of Cryptosporidium spp. and Giardia duodenalis isolates from five hydrographical basins in northern Portugal.

    Science.gov (United States)

    Almeida, André; Moreira, Maria João; Soares, Sónia; de Lurdes Delgado, Maria; Figueiredo, João; Magalhães, Elisabete Silva; Castro, António; Viana Da Costa, Alexandra; Correia da Costa, José Manuel

    2010-06-01

    To understand the situation of water contamination with Cryptosporidium spp. and Giardia spp. in the northern region of Portugal, we have established a long-term program aimed at pinpointing the sources of surface water and environmental contamination, working with the water-supply industry. Here, we describe the results obtained with raw water samples collected in rivers of the 5 hydrographical basins. A total of 283 samples were analyzed using the Method 1623 EPA, USA. Genetic characterization was performed by PCR and sequencing of genes 18S rRNA of Cryptosporidium spp. and beta-giardin of Giardia spp. Infectious stages of the protozoa were detected in 72.8% (206 of 283) of the water samples, with 15.2% (43 of 283) positive for Giardia duodenalis cysts, 9.5% (27 of 283) positive for Cryptosporidium spp. oocysts, and 48.1% (136 of 283) samples positive for both parasites. The most common zoonotic species found were G. duodenalis assemblages A-I, A-II, B, and E genotypes, and Cryptosporidium parvum, Cryptosporidium andersoni, Cryptosporidium hominis, and Cryptosporidium muris. These results suggest that cryptosporidiosis and giardiasis are important public health issues in northern Portugal. To the authors' knowledge, this is the first report evaluating the concentration of environmental stages of Cryptosporidium and Giardia in raw water samples in the northern region of Portugal.

  17. Effects of apolipoproteins on the kinetics of cholesterol exchange

    International Nuclear Information System (INIS)

    Letizia, J.Y.; Phillips, M.C.

    1991-01-01

    The effects of apolipoproteins on the kinetics of cholesterol exchange have been investigated by monitoring the transfer of [ 14 C]cholesterol from donor phospholipid/cholesterol complexes containing human apolipoproteins A, B, or C. Negatively charged discoidal and vesicular particles containing purified apolipoproteins complexed with lipid and a trace of [ 14 C]cholesterol were incubated with a 10-fold excess of neutral, acceptor, small unilamellar vesicles. The donor and acceptor particles were separated by chromatogrphy of DEAE-Sepharose, and the rate of movement of labeled cholesterol was analyzed as a first-order exchange process. The kinetics of exchange of cholesterol from both vesicular and discoidal complexes that contain apoproteins are consistent with an aqueous diffusion mechanism, as has been established previously for PC/cholesterol SUV. Apolipoproteins A-I, A-II, reduced and carboxymethylated A-11, and B-100 present in SUV at the same lipid/protein (w/w) ratio all enhance the rate of cholesterol exchange to about the same degree. Cholesterol molecules exchange more rapidly from discoidal complexes. Generally, as the diameter of apoprotein/phospholipid/cholesterol discs decreases, t 1/2 for cholesterol exchange decreases. Since small bilayer discs have a relatively high ratio of boundary to face surface area, cholesterol molecules desorb more rapidly than from larger discs. The modulation of lipid packing by the apoprotein molecules present at the surface of lipoprotein particles affects the rate of cholesterol exchange from such particles

  18. Acrolein impairs the cholesterol transport functions of high density lipoproteins.

    Science.gov (United States)

    Chadwick, Alexandra C; Holme, Rebecca L; Chen, Yiliang; Thomas, Michael J; Sorci-Thomas, Mary G; Silverstein, Roy L; Pritchard, Kirkwood A; Sahoo, Daisy

    2015-01-01

    High density lipoproteins (HDL) are considered athero-protective, primarily due to their role in reverse cholesterol transport, where they transport cholesterol from peripheral tissues to the liver for excretion. The current study was designed to determine the impact of HDL modification by acrolein, a highly reactive aldehyde found in high abundance in cigarette smoke, on the cholesterol transport functions of HDL. HDL was chemically-modified with acrolein and immunoblot and mass spectrometry analyses confirmed apolipoprotein crosslinking, as well as acrolein adducts on apolipoproteins A-I and A-II. The ability of acrolein-modified HDL (acro-HDL) to serve as an acceptor of free cholesterol (FC) from COS-7 cells transiently expressing SR-BI was significantly decreased. Further, in contrast to native HDL, acro-HDL promotes higher neutral lipid accumulation in murine macrophages as judged by Oil Red O staining. The ability of acro-HDL to mediate efficient selective uptake of HDL-cholesteryl esters (CE) into SR-BI-expressing cells was reduced compared to native HDL. Together, the findings from our studies suggest that acrolein modification of HDL produces a dysfunctional particle that may ultimately promote atherogenesis by impairing functions that are critical in the reverse cholesterol transport pathway.

  19. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.

    Science.gov (United States)

    Thupari, J N; Pinn, M L; Kuhajda, F P

    2001-07-13

    Inhibition of fatty acid synthase (FAS) induces apoptosis in human breast cancer cells in vitro and in vivo without toxicity to proliferating normal cells. We have previously shown that FAS inhibition causes a rapid increase in malonyl-CoA levels identifying malonyl-CoA as a potential trigger of apoptosis. In this study we further investigated the role of malonyl-CoA during FAS inhibition. We have found that: [i] inhibition of FAS with cerulenin causes carnitine palmitoyltransferase-1 (CPT-1) inhibition and fatty acid oxidation inhibition in MCF-7 human breast cancer cells likely mediated by elevation of malonyl-CoA; [ii] cerulenin cytotoxicity is due to the nonphysiological state of increased malonyl-CoA, decreased fatty acid oxidation, and decreased fatty acid synthesis; and [iii] the cytotoxic effect of cerulenin can be mimicked by simultaneous inhibition of CPT-1, with etomoxir, and fatty acid synthesis with TOFA, an acetyl-CoA carboxylase (ACC) inhibitor. This study identifies CPT-1 and ACC as two new potential targets for cancer chemotherapy. Copyright 2001 Academic Press.

  20. Revised Jones Criteria For The Diagnosis of Acute Rheumatic Fever (AHA 2015 - An Indian Perspective

    Directory of Open Access Journals (Sweden)

    KV Sahasranam

    2015-07-01

    Full Text Available Acute Rheumatic Fever (ARF is still a major problem in some developing and low middle income countries though the incidence and prevalence has remarkably reduced in North America and Europe. Ever since T. Duckett Jones in 1944 proposed the Jones criteria, it was modified and later revised by the American Heart Association (AHA in 1992. This was reconfirmed in and AHA sponsored Work shop in 2002. No modification or change was suggested after the introduction of Doppler Echocardiography (DE for the diagnosis of clinical and "subclinical carditis". When a clinical diagnosis by the clinician fails to show evidence of carditis, DE may pick up cases of "subclinical carditis". Moreover, previous recommendations did not include the Classification of Recommendations (Class I, II a, II b, and III and Levels of Evidence (Levels A, B and C. Recently, however, a scientific statement from the American Heart Association (AHA has published an update to the Jones criteria including the use of DE in the diagnosis of ARF.

  1. Biology and Conservation of the Taiwanese Humpback Dolphin, Sousa chinensis taiwanensis.

    Science.gov (United States)

    Wang, John Y; Riehl, Kimberly N; Klein, Michelle N; Javdan, Shiva; Hoffman, Jordan M; Dungan, Sarah Z; Dares, Lauren E; Araújo-Wang, Claryana

    2016-01-01

    The humpback dolphins of the eastern Taiwan Strait were first discovered scientifically in 2002 and since then have received much research attention. We reviewed all information published in peer-reviewed scientific journals on these dolphins and where appropriate and available, peer-reviewed scientific workshop reports and graduate theses were also examined. Recent evidence demonstrated that this population warranted recognition as a subspecies, Sousa chinensis taiwanensis. It is found in a highly restricted and linear strip of coastal waters along central western Taiwan. Numbering fewer than 80 individuals and declining, five main threats (fisheries interactions, habitat loss and degradation, loss of freshwater to estuaries within their habitat, air and water pollution, and noise) threaten the future existence of this subspecies. These dolphins have cultural and religious importance and boast the highest level of legal protection for wildlife in Taiwan. However, despite enormous efforts by local and international non-governmental groups urging immediate conservation actions, there have been no real government efforts to mitigate any existing threats; instead, some of these threats have worsened. Based on recent studies, we suggest the IUCN Red List status be revised to Critically Endangered CR 2a(ii); D for the subspecies. © 2016 Elsevier Ltd. All rights reserved.

  2. Koblenz Higher Administrative Court reproaches complainants with abusing legal protection

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    In its decision of November 18, 1980, the Koblenz Higher Administrative Court of Rhineland-Palatinate dismissed the appeal filed by the complaining party, members of the so-called 'Forum Humanum' against the decisions made by the Koblenz Administrative Court which dismissed their action filed against the partial licence issued for, and the licensing of, the Muelheim-Kaerlich reactor (comp. with first report in 'et' 2/81 p. 145). The complaining party was ordered to pay the costs of the proceedings, including the out-of-court costs of the parties invited to attend (constructor and operator). According to the decision, the value in litigation was fixed at DM 100 000 each for the appeal. Another appeal was not allowed. The substance of both decisions is identical. In decision 7 A II 78/80 it is pointed out that the complaining party appeared in court as a 'public agent' acting in the 'public interest'. Constitutionally, legal protection in administrative matters does not know of any class-action suit. (orig./HSCH) [de

  3. POPULAÇÃO E OCUPAÇÃO DO ESPAÇO: O PAPEL DAS MIGRAÇÕES NO BRASIL

    Directory of Open Access Journals (Sweden)

    Sylvain Souchaud

    2012-07-01

    Full Text Available A população brasileira foi fortemente influenciada em sua distribuição espacial, além de sua estrutura por sexo e idade, por importantes aportes de imigrantes internacionais. Esse aspecto da dinâmica demográfica, no entanto, ficou restrito ao passado, pois, após a II Guerra Mundial, com a diminuição das correntes migratórias internacionais e o intenso crescimento vegetativo da população nacional, foram os próprios brasileiros que orquestraram a distribuição populacional no país por meio das migrações internas em períodos mais recentes. Neste artigo, busca-se apresentar um panorama das migrações no Brasil e suas articulações com diferentes contextos, do século XIX até os dias de hoje. Além disso, destaca-se nos últimos anos a retomada da imigração internacional no Brasil, pois voltaram a surgir migrantes vindos do exterior, ainda pouco numerosos, mas que trazem indícios de que possa haver uma retomada do status de país de imigração.

  4. Solvable Catalyzed Birth-Death-Exchange Competition Model of Three Species

    International Nuclear Information System (INIS)

    Wang Haifeng; Gao Yan; Zhang Heng; Lin Zhenquan

    2009-01-01

    A competition model of three species in exchange-driven aggregation growth is proposed. In the model, three distinct aggregates grow by exchange of monomers and in parallel, birth of species A is catalyzed by species B and death of species A is catalyzed by species C. The rates for both catalysis processes are proportional to kj ν and kj ω respectively, where ν(Ω) is a parameter reflecting the dependence of the catalysis reaction rate of birth (death) on the catalyst aggregate's size. The kinetic evolution behaviors of the three species are investigated by the rate equation approach based on the mean-field theory. The form of the aggregate size distribution of A-species a k (t) is found to be dependent crucially on the two catalysis rate kernel parameters. The results show that (i) in case of μ ≤ 0, the form of a k (t) mainly depends on the competition between self-exchange of species A and species-C-catalyzed death of species A; (ii) in case of ν > 0, the form of a k (t) mainly depends on the competition between species-B-catalyzed birth of species A and species-C-catalyzed death of species A. (interdisciplinary physics and related areas of science and technology)

  5. Assessment of the uncertainty and the proficiency test for accrediting KOLAS of ISO 17025 for a neutron radiography facility

    International Nuclear Information System (INIS)

    Oh, H.; Sim, C.M.; Lim, I.C.; Hong, K.P.; Choi, B.H.

    2004-01-01

    KOLAS(Korea of Lab Accreditation Scheme) is the charter member of ILAS (International Lab Accreditation Scheme) and APLAS (Asia Pacific Lab Accreditation Scheme), which originates from ISO 17025. KATS (Korea Agent of Technology Standard) governs the KOLAS. The KOLAS describes the basis of satisfying those issues related to a quality assurance and management system. The requirements specify an organization, the accommodation and environmental conditions, an uncertainty in the measurement and an inter-laboratory comparison or proficiency test program. The evaluation process of the requirements of certifying KOLAS for HANARO NRF has been proceeded by a neutron radiography laboratory, NRT level II course of SNT-TC-1A II is opened, with 20 persons attending for certification. An inter-laboratory comparison or proficiency test program is conducted through with Kyoto University in accordance with ASTM method for determining the imaging quality in direct thermal neutron radiographic testing (E545-91). In order to determine the uncertainty, dimensional measurements for the calibration fuel pin of the RISO using a profile project is performed with the ASTM practice for thermal neutron radiography of materials (E748-95) (orig.)

  6. Extremely high energy gamma-ray and hadron families with halo (II)

    International Nuclear Information System (INIS)

    Yamashita, S.; Ohsawa, A.; Chinellato, J.A.; Shibuya, E.H.

    1984-01-01

    The five highest energy events with the total observed energy exceeding 10 15 eV, observed by Chacaltaya emulsion chambers, are analysed and their characteristic feature are presented. Those big events are named Andromeda(halo 21,000 TeV and spots 6,140 TeV), Ursa Maior(980 TeV and 1,880 TeV), M.A.I(3,200 TeV and 1,340 TeV), M.A.II(1,300 TeV and 890 TeV) and M.A.III(5,100 TeV and 3,700 TeV). In the energy flow distributions of them, sharp peak indicating concentration of energy is found at small distance from a family center. Such concentration of energy may make a halo. If we represent the characteristic of such concentration of energy as (distance from the family center to the peak) x (energy sum within the distance), its order of magnitude becomes a few GeV.km for each big family. Comparisons are made with the simulation calculation carried out by M. Shibata. (author)

  7. Affinity of serum apolipoproteins for lipid monolayers

    International Nuclear Information System (INIS)

    Ibdah, J.A.

    1987-01-01

    The effects of lipid composition and packing as well as the structure of the protein on the affinities of apolipoproteins for lipid monolayers have been investigated. The adsorption of 14 C-reductively methylated human apolipoproteins A-I and A-II at saturating subphase concentrations to monolayers prepared with synthetic lipids or lipoprotein surface lipids spread at various initial surface pressures has been studied. The adsorption of apolipoproteins is monitored by following the surface radioactivity using a gas flow counter and Wilhelmy plate, respectively. The physical states of the lipid monolayers are evaluated by measurement of the surface pressure-molecular area isotherms using a Langmuir-Adam surface balance. The probable helical regions in various apolipoproteins have been predicted using a secondary structure analysis computer program. The mean residue hydrophobicity and mean residue hydrophobic moment for the predicted helical segments have been calculated. The surface properties of synthetic peptides which are amphipathic helix analogs have been investigated at the air-water and lipid-water interfaces

  8. Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin: a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses.

    Science.gov (United States)

    Filipe, Paulo; Morlière, Patrice; Silva, João N; Mazière, Jean-Claude; Patterson, Larry K; Freitas, João P; Santus, R

    2013-01-01

    There are numerous studies concerning the effect of UVB light on skin cells but fewer on other skin components such as the interstitial fluid. This review highlights high-density lipoprotein (HDL) and low-density lipoprotein (LDL) as important targets of UVB in interstitial fluid. Tryptophan residues are the sole apolipoprotein residues absorbing solar UVB. The UVB-induced one-electron oxidation of Trp produces (•)Trp and (•)O2 (-) radicals which trigger lipid peroxidation. Immunoblots from buffered solutions or suction blister fluid reveal that propagation of photooxidative damage to other residues such as Tyr or disulfide bonds produces intra- and intermolecular bonds in apolipoproteins A-I, A-II, and B100. Partial repair of phenoxyl tyrosyl radicals (TyrO(•)) by α -tocopherol is observed with LDL and HDL on millisecond or second time scales, whereas limited repair of α -tocopherol by carotenoids occurs in only HDL. More effective repair of Tyr and α -tocopherol is observed with the flavonoid, quercetin, bound to serum albumin, but quercetin is less potent than new synthetic polyphenols in inhibiting LDL lipid peroxidation or restoring α -tocopherol. The systemic consequences of HDL and LDL oxidation and the activation and/or inhibition of signalling pathways by oxidized LDL and their ability to enhance transcription factor DNA binding activity are also reviewed.

  9. Plasma Lipoproteins as Mediators of the Oxidative Stress Induced by UV Light in Human Skin: A Review of Biochemical and Biophysical Studies on Mechanisms of Apolipoprotein Alteration, Lipid Peroxidation, and Associated Skin Cell Responses

    Directory of Open Access Journals (Sweden)

    Paulo Filipe

    2013-01-01

    Full Text Available There are numerous studies concerning the effect of UVB light on skin cells but fewer on other skin components such as the interstitial fluid. This review highlights high-density lipoprotein (HDL and low-density lipoprotein (LDL as important targets of UVB in interstitial fluid. Tryptophan residues are the sole apolipoprotein residues absorbing solar UVB. The UVB-induced one-electron oxidation of Trp produces •Trp and O2•- radicals which trigger lipid peroxidation. Immunoblots from buffered solutions or suction blister fluid reveal that propagation of photooxidative damage to other residues such as Tyr or disulfide bonds produces intra- and intermolecular bonds in apolipoproteins A-I, A-II, and B100. Partial repair of phenoxyl tyrosyl radicals (TyrO• by α-tocopherol is observed with LDL and HDL on millisecond or second time scales, whereas limited repair of α-tocopherol by carotenoids occurs in only HDL. More effective repair of Tyr and α-tocopherol is observed with the flavonoid, quercetin, bound to serum albumin, but quercetin is less potent than new synthetic polyphenols in inhibiting LDL lipid peroxidation or restoring α-tocopherol. The systemic consequences of HDL and LDL oxidation and the activation and/or inhibition of signalling pathways by oxidized LDL and their ability to enhance transcription factor DNA binding activity are also reviewed.

  10. PTA and stenting for various types of Budd-Chiari syndrome

    International Nuclear Information System (INIS)

    Zhang Xinbao

    2011-01-01

    Objective: To investigate and evaluate PTA and stenting for various types of Budd-Chiari syndrome (BCS). Methods: 89 patients with BCS were diagnosed and treated during 7 years. The interventional procedures included: Percutaneous balloon dilatation (PBD) of inferior vena cava (IVC), PBD and stent placement for IVC, hepatic vein angioplasty via trans jugular vein, hepatic vein angioplasty via transhepatic and trans jugular approach, accessory hepatic vein angioplasty, percutaneous dual balloon dilatation for IVC and hepatic vein, and percutanous dual stent placement for IVC and hepatic vein. Results: The achievement ratio of PTA and stent placement was 96% and the mortality was 0%. The serious complication of PTA and stent placement of BCS was penetration into the pericardium, endovascular stent migration into right atrium. Conclusion: 1. PTA is a reliable procedures in treating type I a, II and III BCS, and TIPPS is useful for type I b BCS. But PTA and stenting is necessary for patients with type IV BCS. 2. Thrombolysis is needed for patients with type III, IV BCS. 3. Guiding of Color Doppler Ultrasound can improve the success of percutanous hepatic vein and reduce complications. (authors)

  11. Serum lipid levels and steroidal hormones in women runners with irregular menses.

    Science.gov (United States)

    Thompson, D L; Snead, D B; Seip, R L; Weltman, J Y; Rogol, A D; Weltman, A

    1997-02-01

    This study compared the lipid profile of women runners with menstrual cycle irregularities with their normally menstruating counterparts. Relationships among selected steroid hormones and serum lipid levels in 10 eumenorrheic (EU) and 8 oligo-/amenorrheic (O/A) women runners and 6 eumenorrheic controls (CON) were examined. Serum 17 beta-estradiol (E2), progesterone (Prog), and dehydroepiandrosterone-sulfate (DHEAS) concentrations were determined in daily blood samples for 21 days, and integrated concentrations were calculated. Fasting blood samples were analyzed for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), HDL2, HDL3, triglycerides (Trig), and apolipoproteins A-1, A-II, and B. The O/A group had significantly lower E2 and Prog than EU or CON groups. Women in the CON group had lower HDL-C and HDL3 than the runners. With all women grouped together, E2 was not significantly correlated with any measured blood lipid parameters. On the other hand, DHEAS was significantly correlated with HDL-C, HDL2, and apolipoprotein A-I. These data demonstrate that women runners, regardless of menstrual cycle status, exhibit higher HDL-C concentrations than CON and supports previous research reporting a positive association between DHEAS and HDL-C.

  12. Differential expression of P-type ATPases in intestinal epithelial cells: Identification of putative new atp1a1 splice-variant

    International Nuclear Information System (INIS)

    Rocafull, Miguel A.; Thomas, Luz E.; Barrera, Girolamo J.; Castillo, Jesus R. del

    2010-01-01

    P-type ATPases are membrane proteins that couple ATP hydrolysis with cation transport across the membrane. Ten different subtypes have been described. In mammalia, 15 genes of P-type ATPases from subtypes II-A, II-B and II-C, that transport low-atomic-weight cations (Ca 2+ , Na + , K + and H + ), have been reported. They include reticulum and plasma-membrane Ca 2+ -ATPases, Na + /K + -ATPase and H + /K + -ATPases. Enterocytes and colonocytes show functional differences, which seem to be partially due to the differential expression of P-type ATPases. These enzymes have 9 structural motifs, being the phosphorylation (E) and the Mg 2+ ATP-binding (H) motifs the most preserved. These structural characteristics permitted developing a Multiplex-Nested-PCR (MN-PCR) for the simultaneous identification of different P-type ATPases. Thus, using MN-PCR, seven different cDNAs were cloned from enterocytes and colonocytes, including SERCA3, SERCA2, Na + /K + -ATPase α1-isoform, H + /K + -ATPase α2-isoform, PMCA1, PMCA4 and a cDNA-fragment that seems to be a new cassette-type splice-variant of the atp1a1 gen. PMCA4 in enterocytes and H + /K + -ATPase α2-isoform in colonocytes were differentially expressed. This cell-specific expression pattern is related with the distinctive enterocyte and colonocyte functions.

  13. Self-sustained spin-polarized current oscillations in multiquantum well structures

    Energy Technology Data Exchange (ETDEWEB)

    Escobedo, Ramon [Departamento de Matematica Aplicada y Ciencias de la Computacion, Universidad de Cantabria, 39005 Santander (Spain); Carretero, Manuel; Bonilla, Luis L [G. Millan Institute, Fluid Dynamics, Nanoscience and Industrial Mathematics, Universidad Carlos III de Madrid, 28911 Leganes (Spain); Platero, Gloria [Instituto de Ciencia de Materiales, CSIC, 28049 Cantoblanco (Spain)], E-mail: escobedo@unican.es, E-mail: manuel.carretero@uc3m.es, E-mail: bonilla@ing.uc3m.es, E-mail: gplatero@icmm.csic.es

    2009-01-15

    Nonlinear transport through diluted magnetic semiconductor nanostructures is investigated. We have considered a II-VI multiquantum well nanostructure whose wells are selectively doped with Mn. The response to a dc voltage bias may be either a stationary or an oscillatory current. We have studied the transition from stationary to time-dependent current as a function of the doping density and the number of quantum wells. Analysis and numerical solution of a nonlinear spin transport model shows that the current in a structure without magnetic impurities is stationary, whereas current oscillations may appear if at least one well contains magnetic impurities. For long structures having two wells with magnetic impurities, a detailed analysis of nucleation of charge dipole domains shows that self-sustained current oscillations are caused by repeated triggering of dipole domains at the magnetic wells and motion towards the collector. Depending on the location of the magnetic wells and the voltage, dipole domains may be triggered at both wells or at only one. In the latter case, the well closer to the collector may inhibit domain motion between the first and the second well inside the structure. Our study could allow design of oscillatory spin-polarized current injectors.

  14. In vitro incorporation of radiolabeled cholesteryl esters into high and low density lipoproteins

    International Nuclear Information System (INIS)

    Terpstra, A.H.; Nicolosi, R.J.; Herbert, P.N.

    1989-01-01

    We have developed and validated a method for in vitro incorporation of radiolabeled cholesteryl esters into low density (LDL) and high density lipoproteins (HDL). Radiolabeled cholesteryl esters dissolved in absolute ethanol were mixed with LDL or HDL in the presence of lipoprotein-deficient serum (LPDS) as a source of core lipid transfer activity. The efficiency of incorporation was dependent on: (a) the core lipid transfer activity and quantity of LPDS, (b) the mass of added radiolabeled cholesteryl esters, (c) the length of incubation, and (d) the amount of acceptor lipoprotein cholesterol. The tracer incorporation was documented by repeat density gradient ultracentrifugation, agarose gel electrophoresis, and precipitation with heparin-MnCl2. The radiolabeling conditions did not affect the following properties of the lipoproteins: (1) chemical composition, (2) electrophoretic mobility on agarose gels, (3) hydrated density, (4) distribution of apoproteins on SDS gels, (5) plasma clearance rates, and (6) immunoprecipitability of HDL apoproteins A-I and A-II. Rat HDL containing radiolabeled cholesteryl esters incorporated in vitro had plasma disappearance rates identical to HDL radiolabeled in vivo

  15. Molecular epidemiology and multilocus sequence analysis of potentially zoonotic Giardia spp. from humans and dogs in Jamaica.

    Science.gov (United States)

    Lee, Mellesia F; Cadogan, Paul; Eytle, Sarah; Copeland, Sonia; Walochnik, Julia; Lindo, John F

    2017-01-01

    Giardia spp. are the causative agents of intestinal infections in a wide variety of mammals including humans and companion animals. Dogs may be reservoirs of zoonotic Giardia spp.; however, the potential for transmission between dogs and humans in Jamaica has not been studied. Conventional PCR was used to screen 285 human and 225 dog stool samples for Giardia targeting the SSU rDNA gene followed by multilocus sequencing of the triosephosphate isomerase (tpi), glutamate dehydrogenase (gdh), and β-giardin (bg) genes. Prevalence of human infections based on PCR was 6.7 % (19/285) and canine infections 19.6 % (44/225). Nested PCR conducted on all 63 positive samples revealed the exclusive presence of assemblage A in both humans and dogs. Sub-assemblage A-II was responsible for 79.0 % (15/19) and 70.5 % (31/44) of the infections in humans and dogs, respectively, while sub-assemblage A-I was identified at a rate of 15.8 % (3/19) and 29.5 % (13/44) in humans and dogs, respectively. The predominance of a single circulating assemblage among both humans and dogs in Jamaica suggests possible zoonotic transmission of Giardia infections.

  16. AFM, SEM and in situ RHEED study of Cu texture evolution on amorphous carbon by oblique angle vapor deposition

    International Nuclear Information System (INIS)

    Tang, F.; Gaire, C.; Ye, D.-X.; Karabacak, T.; Lu, T.-M.; Wang, G.-C.

    2005-01-01

    The evolution of the crystal orientation of a Cu film grown on an amorphous carbon substrate without intentional heating under 75±6 deg. oblique angle vapor deposition was investigated ex-situ by atomic force microscopy (AFM) and scanning electron microscopy (SEM), and in-situ by reflection high-energy electron diffraction (RHEED). At the initial stage of growth ( ∼100 nm thick) the diffraction pattern started to break symmetrically from the middle of the (111) and (200) rings representing the absence of (111) and (200) planes parallel to the substrate. However, after this transition stage, at the thickness of ∼410 nm, the intensity distribution of diffraction patterns appeared asymmetric about the middle of the rings, which is interpreted as the appearance of a tilted (111) texture. Finally the diffraction patterns developed into separated short arcs and showed only a II-O (two-orientation) texture. By comparing RHEED patterns with the SEM and AFM images of the final film, we argue that the tilted columns having tilted (111) top faces dominate in the later stage of growth. Furthermore, considering the geometry of crystals and shadowing effects, we argue that the vertices of columns having the highest growth velocity normal to the substrate and therefore receiving the maximum flux will dominate the film growth and determine the tilt angle of the texture and the preference of the azimuthal angle orientation

  17. A network model of correlated growth of tissue stiffening in pulmonary fibrosis

    International Nuclear Information System (INIS)

    Oliveira, Cláudio L N; Suki, Béla; Bates, Jason H T

    2014-01-01

    During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not lead to significant increases in the bulk modulus of the lung until these local remodeled regions have become sufficiently numerous and extensive to percolate in a continuous path across the entire tissue (Bates et al 2007 Am. J. Respir. Crit. Care Med. 176 617). This model, however, did not include the possibility of spatially correlated deposition of collagen. In the present study, we investigate whether spatial correlations influence the bulk modulus in a two-dimensional elastic network model of lung tissue. Random collagen deposition at a single site is modeled by increasing the elastic constant of the spring at that site by a factor of 100. By contrast, correlated collagen deposition is represented by stiffening the springs encountered along a random walk starting from some initial spring, the rationale being that excess collagen deposition is more likely in the vicinity of an already stiff region. A combination of random and correlated deposition is modeled by performing random walks of length N from randomly selected initial sites, the balance between the two processes being determined by N. We found that the dependence of bulk modulus, B(N,c), on both N and the fraction of stiff springs, c, can be described by a strikingly simple set of empirical equations. For c<0.3, B(N,c) exhibits exponential growth from its initial value according to B(N,c)≈B 0 exp(2c)[1+c β ln(N a I )], where β=0.994± 0.024 and a I =0.54±0.026. For intermediate concentrations of stiffening, 0.3⩽c⩽0.8, another exponential rule describes the bulk modulus as B(N,c)=4B 0 exp[a II (c−c c )], where a II and c c are parameters that depend on N. For c>0.8, B(N,c) is linear in c and independent of N, such that B(N,c)=100 B 0 −100a III (1−c)B 0

  18. Evaluation of the use of organic acids in the conservation of sorghum grains (Sorghum bicolor L. Moench during storage/ Avaliação do uso de ácidos orgânicos na conservação de grãos de sorgo (Sorghum bicolor L. Moench durante o armazenamento

    Directory of Open Access Journals (Sweden)

    Marcelo Zafalon Peter

    2008-08-01

    Full Text Available The objective of this work was to study the use of organic acids in storage of sorghum grains, as an efficient alternative for small and medium producers, that lack structures for artificial drying and technical storage. The grains were stored in bulk in wood boxes, for six months, consisting of five treatments: I dried grains (13.15% of moisture, without incorporation of acids; II humid grains (21,54% of moisture without incorporation of acids; II-A; II-P and II-M, the latter three, with incorporation of acetic acid, propionic and the mixture of both, in the proportion of 1:1, respectively, in the dosis of 2 kg of acid per 100 kg of grains. Evaluation of grains was made at 1, 60, 120 and 180 days of storage, analysing humidity, carboydrate, crude protein, ether extract, ash, volumetric weight and incidence of insects. For the storage of 180 days, under the same environment conditions, it is concluded that: 1 the incorporation of acids at the moment of storage of humid sorghum grains allows superior preservative effects when compared to dry grains; 2 the mixture of acids, showed superior quantitative and qualitative preservative effects of the grains, followed by propionic acid, and acetic, respectively; 3 the storage of humid grains, without addition of acids, does not allow adequate grain conservation, not even for a period lesser than 60 days.O objetivo deste trabalho foi estudar a utilização de ácidos orgânicos no armazenamento de grãos de sorgo, como alternativa eficiente para pequenos e médios produtores, que não dispõem de estruturas de secagem artificial e armazenamento tecnificado. Os grãos foram armazenados a granel, em caixas de madeira, por seis meses, consistindo de cinco tratamentos: I grãos secos (13,15% de umidade, sem incorporação de ácidos; II grãos úmidos (21,54% de umidade, sem incorporação de ácidos; II-A; II-P e II-M, sendo os três últimos grãos úmidos (21,54% de umidade, com incorporação de

  19. Impact of an angiotensin analogue in treating thermal and combined radiation injuries

    Science.gov (United States)

    Jadhav, Sachin Suresh

    Background: In recent years there has been a growing concern regarding the use of nuclear weapons by terrorists. Such incidents in the past have shown that radiation exposure is often accompanied by other forms of trauma such as burns, wounds or infection; leading to increased mortality rates among the affected individuals. This increased risk with combined radiation injury has been attributed to the delayed wound healing observed in this injury. The Renin-Angiotensin System (RAS) has emerged as a critical regulator of wound healing. Angiotensin II (A-II) and Angiotensin (1-7) [A(1-7)] have been shown to accelerate the rate of wound healing in different animal models of cutaneous injury. Nor-Leu3-Angiotensin (1-7) [Nor-Leu3-A (1-7)], an analogue of A(1-7), is more efficient than both A-II and A(1-7) in its ability to improve wound healing and is currently in phase III clinical trials for the treatment of diabetic foot ulcers. Aims: The three main goals of this study were to; 1) Develop a combined radiation and burn injury (CRBI) model and a radiation-induced cutaneous injury model to study the pathophysiological effects of these injuries on dermal wound healing; 2) To treat thermal and CRBI injuries using Nor-Leu 3-A (1-7) and decipher the mechanism of action of this peptide and 3) Develop an in-vitro model of CRBI using dermal cells in order to study the effect of CRBI on individual cell types involved in wound healing. Results: CRBI results in delayed and exacerbated apoptosis, necrosis and inflammation in injured skin as compared to thermal injury by itself. Radiation-induced cutaneous injury shows a radiation-dose dependent increase in inflammation as well as a chronic inflammatory response in the higher radiation exposure groups. Nor-Leu3-A (1-7) can mitigate thermal and CRBI injuries by reducing inflammation, oxidative stress and DNA damage while increasing the rate of proliferation of dermal stem cells and re-epithelialization of injured skin. The in

  20. Preparation, Conduct and Evaluation of Exercises to Test Preparedness for a Nuclear or Radiological Emergency

    International Nuclear Information System (INIS)

    2010-01-01

    The aim of this publication is to serve as a practical tool for the preparation, conduct and evaluation of exercises to test preparedness for response to a nuclear or radiological emergency. It fulfils in part the functions assigned to the IAEA under Article 5.a(ii) of the Convention on Assistance in Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), namely, to collect and disseminate to States Parties and Member States information concerning the methodologies, techniques and available results of research on such emergencies. To ensure effective response to radiation emergencies when needed, provisions should be made for regular training of emergency response personnel. As stated in Preparedness and Response for a Nuclear or Radiological Emergency (Safety Requirements, Safety Standard Series No. GS-R-2), 'The operator and the response organizations shall make arrangements for the selection of personnel and training to ensure that the personnel have the requisite knowledge, skills, abilities, equipment, procedures and other arrangements to perform their assigned response functions'. A further requirement is that 'Exercise programmes shall be conducted to ensure that all specified functions required to be performed for emergency response and all organizational interfaces for facilities in threat category I, II or III and the national level programmes for threat category IV or V are tested at suitable intervals'. In 2004 the IAEA General Conference, in resolution GC(48)/RES/10 encouraged Member States to 'implement the Safety Requirements for Preparedness and Response to a Nuclear or Radiological Emergency'. This document is published as part of the IAEA Emergency Preparedness and Response Series to assist in meeting these requirements and to fulfil Article 5 of the Assistance Convention. It was developed based on a number of assumptions about national and local capabilities. Therefore, the exercise structure, terms and scenarios must be

  1. The influence of continuous and intermittent traffic noise on sleep

    Science.gov (United States)

    Eberhardt, J. L.; Stråle, L.-O.; Berlin, M. H.

    1987-08-01

    The effects of road traffic noise on sleep were studied in the laboratory using nine young male adults (aged 20-26). The subjects were exposed to noise with different temporal characteristics: (i) continuous traffic noise of 36 dB(A) or 45 dB(A), (ii) intermittent noise of 50 truck passages with L pmax = 45 dB(A) ( L eq = 29 dB(A)) or L pmax = 55 dB(A) ( L eq = 36 dB(A)), and (iii) a combination of continuous (45 dB(A)) and intermittent ( L pmax = 55 dB(A)) traffic noise. For one noise condition (intermittent 55 dB(A)) the effect of the use of ear plugs was also studied. The intermittent noise of L pmax = 45 dB(A) caused transitions towards lighter sleep, whereas 55 dB(A) was needed to induce awakening effects. It could be shown that the probability for arousal reactions depends on the emergence of the noise peaks from the background, rather than the absolute noise peak level. Continuous traffic noise of 45 dB(A) caused REM sleep deficits, while intermittent traffic noise of L pmax = 45 dB(A) caused stage III+IV deficits. The night with ear plugs was virtually undisturbed. After nights with REM sleep deficits the subjective sleep quality was rated lower and mood was influenced adversely. For the types of exposure used in the present investigation L eq alone is not an adequate descriptor of the noise dose, relating to the sleep disturbances observed. From the present experiment, together with other existing data, it might be concluded that the WHO recommendation of L eq = 35 dB(A) is adequate, but should be supplemented with a maximum noise level, as expressed for example in L pmax or LI, that should not be exceeded.

  2. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme, Training Materials

    International Nuclear Information System (INIS)

    2013-01-01

    The aim of these training materials is to provide a practical tool for emergency planning for a State embarking on a nuclear power programme, and to fulfil, in part, functions assigned to the IAEA under the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the Assistance Convention). Under Article 5.a(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. One of the concerns associated with nuclear power is the possibility that a State embarking on a nuclear power programme might not have sufficient capabilities and therefore would not be adequately prepared to respond to a radiation emergency caused by severe accident conditions. Protecting the public, the environment and property in the event of a failure of any level of defence in depth is the most important safety objective. A robust framework for emergency preparedness and response to a radiation emergency forms the last level of defence in depth and, as such, must be developed and implemented by any State embarking on a nuclear power programme, using best international practices. The establishment of capabilities and arrangements for emergency preparedness and response to severe accident conditions is one of the principal tasks in the development of a national infrastructure for nuclear power. State of the art emergency preparedness and response is a key element in achieving overall plant safety. This training course complements the IAEA publication 'Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme' (EPR-Embarking 2012). These materials are designed to help States apply the guidance in EPR-Embarking 2012, in order to develop the capability to adequately prepare for and respond to a radiation emergency after the commissioning and start of

  3. Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial.

    Science.gov (United States)

    Chiva-Blanch, G; Magraner, E; Condines, X; Valderas-Martínez, P; Roth, I; Arranz, S; Casas, R; Navarro, M; Hervas, A; Sisó, A; Martínez-Huélamo, M; Vallverdú-Queralt, A; Quifer-Rada, P; Lamuela-Raventos, R M; Estruch, R

    2015-01-01

    Moderate alcohol consumption exerts a cardioprotective effect, but no studies have evaluated the alcohol-independent cardiovascular effects of the non-alcoholic components of beer. We aimed to evaluate the effects of ethanol and the phenolic compounds of beer on classical and novel cardiovascular risk factors. Thirty-three high risk male volunteers were included in a randomized, crossover feeding trial. After a washout period, all subjects received beer (30 g alcohol/d, 660 mL), the equivalent amount of polyphenols as non-alcoholic beer (990 mL), and gin (30 g alcohol/d, 100 mL) for 4 weeks. All outcomes were evaluated before and after each intervention period. Moderate alcohol consumption increased serum HDL-cholesterol (∼5%), ApoA-I (∼6%), ApoA-II (∼7%) and adiponectin (∼7%), and decreased serum fibrinogen (∼8%), and interleukin (IL)-5 (∼14%) concentrations, whereas the non-alcoholic fraction of beer (mainly polyphenols) increased the receptor antagonist of IL-1 (∼24%), and decreased lymphocyte expression of lymphocyte function-associated antigen-1 (∼11%), lymphocyte and monocyte expression of Sialil-Lewis X (∼16%) and monocyte expression of CCR2 (∼31%), and tumor necrosis factor (TNF)-β (∼14%) and IL-15 (∼22%) plasma concentrations. No changes were observed in glucose metabolism parameters or in body weight and adiposity parameters. The phenolic content of beer reduces leukocyte adhesion molecules and inflammatory biomarkers, whereas alcohol mainly improves the lipid profile and reduces some plasma inflammatory biomarkers related to atherosclerosis. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Steam Reforming of Acetic Acid over Co-Supported Catalysts: Coupling Ketonization for Greater Stability

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Stephen D. [Energy and Environmental; Spies, Kurt A. [Energy and Environmental; Mei, Donghai [Energy and Environmental; Kovarik, Libor [Energy and Environmental; Kutnyakov, Igor [Energy and Environmental; Li, Xiaohong S. [Energy and Environmental; Lebarbier Dagle, Vanessa [Energy and Environmental; Albrecht, Karl O. [Energy and Environmental; Dagle, Robert A. [Energy and Environmental

    2017-09-11

    We report on the markedly improved stability of a novel 2-bed catalytic system, as compared to a conventional 1-bed steam reforming catalyst, for the production of H2 from acetic acid. The 2-bed catalytic system comprises of i) a basic oxide ketonization catalyst for the conversion of acetic acid to acetone, and a ii) Co-based steam reforming catalyst, both catalytic beds placed in sequence within the same unit operation. Steam reforming catalysts are particularly prone to catalytic deactivation when steam reforming acetic acid, used here as a model compound for the aqueous fraction of bio-oil. Catalysts comprising MgAl2O4, ZnO, CeO2, and activated carbon (AC) both with and without Co-addition were evaluated for conversion of acetic acid and acetone, its ketonization product, in the presence of steam. It was found that over the bare oxide support only ketonization activity was observed and coke deposition was minimal. With addition of Co to the oxide support steam reforming activity was facilitated and coke deposition was significantly increased. Acetone steam reforming over the same Co-supported catalysts demonstrated more stable performance and with less coke deposition than with acetic acid feedstock. DFT analysis suggests that over Co surface CHxCOO species are more favorably formed from acetic acid versus acetone. These CHxCOO species are strongly bound to the Co catalyst surface and could explain the higher propensity for coke formation from acetic acid. Based on these findings, in order to enhance stability of the steam reforming catalyst a dual-bed (2-bed) catalyst system was implemented. Comparing the 2-bed and 1-bed (Co-supported catalyst only) systems under otherwise identical reaction conditions the 2-bed demonstrated significantly improved stability and coke deposition was decreased by a factor of 4.

  5. Injection dexamethasone in preventing postoperative nausea and vomiting: a comparison with placebo in the patients undergoing laparoscopic cholecystectomy

    International Nuclear Information System (INIS)

    Kashmiri, Z.U.A.; Sheikh, Z.; Haider, S.

    2006-01-01

    To determine the efficacy of intravenous dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy (lap-chole) and comparing it with normal saline (placebo). After the approval of the hospital's ethical committee, the study was conducted on 60 patients who were randomly divided into two groups, each group containing 30 patients. All belonged to A.S.A-I and A.S.A-II. Randomization was done by envelope draw method. Injections dexamethasone (8 mg in 2mls) and normal saline ( 2 mls ) were given intravenously to respective groups just before induction of anesthesia. Fisher's exact test was applied to compare proportion of PONV between two groups for the recovery room data, while Chi-square test was applied to compare the proportion of PONV between two groups during first 12 hours and second 12 hours. The p-value was calculated at the level of significance chosen as 0.05. In the recovery room where the patient stayed for one hour 10% of patients in the dexamethasone group in comparison with 33% of the patients in the placebo group experienced PONV (p=0.028). In the ward, during first 12 hours observation period, 27% of the patients in the dexamethasone group in comparison with 43% of the patients in the placebo group experienced PONV (p=0.176). During the second 12 hours observation period, 30% of the patients in the dexamethasone in comparison with 80% of the patients in the placebo group experienced PONV (p<0.001). (author)

  6. CdCl2 passivation of polycrystalline CdMgTe and CdZnTe absorbers for tandem photovoltaic cells

    Science.gov (United States)

    Swanson, Drew E.; Reich, Carey; Abbas, Ali; Shimpi, Tushar; Liu, Hanxiao; Ponce, Fernando A.; Walls, John M.; Zhang, Yong-Hang; Metzger, Wyatt K.; Sampath, W. S.; Holman, Zachary C.

    2018-05-01

    As single-junction silicon solar cells approach their theoretical limits, tandems provide the primary path to higher efficiencies. CdTe alloys can be tuned with magnesium (CdMgTe) or zinc (CdZnTe) for ideal tandem pairing with silicon. A II-VI/Si tandem holds the greatest promise for inexpensive, high-efficiency top cells that can be quickly deployed in the market using existing polycrystalline CdTe manufacturing lines combined with mature silicon production lines. Currently, all high efficiency polycrystalline CdTe cells require a chloride-based passivation process to passivate grain boundaries and bulk defects. This research examines the rich chemistry and physics that has historically limited performance when extending Cl treatments to polycrystalline 1.7-eV CdMgTe and CdZnTe absorbers. A combination of transmittance, quantum efficiency, photoluminescence, transmission electron microscopy, and energy-dispersive X-ray spectroscopy clearly reveals that during passivation, Mg segregates and out-diffuses, initially at the grain boundaries but eventually throughout the bulk. CdZnTe exhibits similar Zn segregation behavior; however, the onset and progression is localized to the back of the device. After passivation, CdMgTe and CdZnTe can render a layer that is reduced to predominantly CdTe electro-optical behavior. Contact instabilities caused by inter-diffusion between the layers create additional complications. The results outline critical issues and paths for these materials to be successfully implemented in Si-based tandems and other applications.

  7. The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine.

    Directory of Open Access Journals (Sweden)

    Scarlett B Pinnock

    2010-10-01

    Full Text Available The formation of new neurons continues into adult life in the dentate gyrus of the rat hippocampus, as in many other species. Neurogenesis itself turns out to be highly labile, and is regulated by a number of factors. One of these is the serotoninergic system: treatment with drugs (such as the SSRI fluoxetine markedly stimulates mitosis in the progenitor cells of the dentate gyrus. But this process has one remarkable feature: it takes at least 14 days of continuous treatment to be effective. This is despite the fact that the pharmacological action of fluoxetine occurs within an hour or so of first administration. This paper explores the role of BDNF in this process, using the effect of a Trk antagonist (K252a on the labelling of progenitor cells with the mitosis marker Ki67 and the associated expression of pCREB and Wnt3a. These experiments show that (i Fluoxetine increased Ki67 counts, as well as pCREB and Wnt3a expression in the dentate gyrus. The action of fluoxetine on the progenitor cells and on pCREB (but not Wnt3a depends upon Trk receptor activation, since it was prevented by icv infusion of K252a. (ii These receptors are required for both the first 7 days of fluoxetine action, during which no apparent change in progenitor mitosis occurs, as well as the second 7 days. Increased pCREB was always associated with progenitor cell mitosis, but Wnt3a expression may be necessary but not sufficient for increased progenitor cell proliferation. These results shed new light on the action of fluoxetine on neurogenesis in the adult dentate gyrus, and have both clinical and experimental interest.

  8. The lion in West Africa is critically endangered.

    Science.gov (United States)

    Henschel, Philipp; Coad, Lauren; Burton, Cole; Chataigner, Beatrice; Dunn, Andrew; MacDonald, David; Saidu, Yohanna; Hunter, Luke T B

    2014-01-01

    The African lion has declined to African lions from other extant African populations. Interventions to save West African lions are urgently required. However formulating effective conservation strategies has been hampered by a lack of data on the species' current distribution, status, and potential management deficiencies of protected areas (PAs) harboring lions. Our study synthesized available expert opinion and field data to close this knowledge gap, and formulate recommendations for the conservation of West African lions. We undertook lion surveys in 13 large (>500 km²) PAs and compiled evidence of lion presence/absence for a further eight PAs. All PAs were situated within Lion Conservation Units, geographical units designated as priority lion areas by wildlife experts at a regional lion conservation workshop in 2005. Lions were confirmed in only 4 PAs, and our results suggest that only 406 (273-605) lions remain in West Africa, representing lion range is estimated at 49,000 km², or 1.1% of historical range in West Africa. PAs retaining lions were larger than PAs without lions and had significantly higher management budgets. We encourage revision of lion taxonomy, to recognize the genetic distinctiveness of West African lions and highlight their potentially unique conservation value. Further, we call for listing of the lion as critically endangered in West Africa, under criterion C2a(ii) for populations with lion range states in West Africa, we call for urgent mobilization of investment from the international community to assist range states to increase management effectiveness of PAs retaining lions.

  9. Genotypic and phenotypic characterization of Clostridium perfringens isolates from Darmbrand cases in post-World War II Germany.

    Science.gov (United States)

    Ma, Menglin; Li, Jihong; McClane, Bruce A

    2012-12-01

    Clostridium perfringens type C strains are the only non-type-A isolates that cause human disease. They are responsible for enteritis necroticans, which was termed Darmbrand when occurring in post-World War II Germany. Darmbrand strains were initially classified as type F because of their exceptional heat resistance but later identified as type C strains. Since only limited information exists regarding Darmbrand strains, this study genetically and phenotypically characterized seven 1940s era Darmbrand-associated strains. Results obtained indicated the following. (i) Five of these Darmbrand isolates belong to type C, carry beta-toxin (cpb) and enterotoxin (cpe) genes on large plasmids, and express both beta-toxin and enterotoxin. The other two isolates are cpe-negative type A. (ii) All seven isolates produce highly heat-resistant spores with D(100) values (the time that a culture must be kept at 100°C to reduce its viability by 90%) of 7 to 40 min. (iii) All of the isolates surveyed produce the same variant small acid-soluble protein 4 (Ssp4) made by type A food poisoning isolates with a chromosomal cpe gene that also produce extremely heat-resistant spores. (iv) The Darmbrand isolates share a genetic background with type A chromosomal-cpe-bearing isolates. Finally, it was shown that both the cpe and cpb genes can be mobilized in Darmbrand isolates. These results suggest that C. perfringens type A and C strains that cause human food-borne illness share a spore heat resistance mechanism that likely favors their survival in temperature-abused food. They also suggest possible evolutionary relationships between Darmbrand strains and type A strains carrying a chromosomal cpe gene.

  10. Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.

    Science.gov (United States)

    Voitychuk, Oleg I; Strutynskyi, Ruslan B; Yagupolskii, Lev M; Tinker, Andrew; Moibenko, Olexiy O; Shuba, Yaroslav M

    2011-02-01

    A class of drugs known as K(ATP) -channel openers induce cardioprotection. This study examined the effects of the novel K(ATP) -channel opener, the fluorine-containing pinacidil derivative, flocalin, on cardiac-specific K(ATP) -channels, excitability of native cardiac myocytes and on the ischaemic heart. The action of flocalin was investigated on: (i) membrane currents through cardiac-specific K(ATP) -channels (I(KATP) ) formed by K(IR) 6.2/SUR2A heterologously expressed in HEK-293 cells (HEK-293(₆.₂/₂A) ); (ii) excitability and intracellular Ca²(+) ([Ca²(+) ](i) ) transients of cultured rat neonatal cardiac myocytes; and (iii) functional and ultrastructural characteristics of isolated guinea-pig hearts subjected to ischaemia-reperfusion. Flocalin concentration-dependently activated a glibenclamide-sensitive I(KATP) in HEK-293(₆.₂/₂A) cells with an EC₅₀= 8.1 ± 0.4 µM. In cardiac myocytes, flocalin (5 µM) hyperpolarized resting potential by 3-5 mV, markedly shortened action potential duration, reduced the amplitude of [Ca²(+) ](i) transients by 2-3-fold and suppressed contraction. The magnitude and extent of reversibility of these effects depended on the type of cardiac myocytes. In isolated hearts, perfusion with 5 µmol·L⁻¹ flocalin, before inducing ischaemia, facilitated restoration of contraction during reperfusion, decreased the number of extrasystoles, prevented the appearance of coronary vasoconstriction and reduced damage to the cardiac tissue at the ultrastructural level (state of myofibrils, membrane integrity, mitochondrial cristae structure). Flocalin induced potent cardioprotection by activating cardiac-type K(ATP) -channels with all the benefits of the presence of fluorine group in the drug structure: higher lipophilicity, decreased toxicity, resistance to oxidation and thermal degradation, decreased metabolism in the organism and prolonged therapeutic action. © 2011 The Authors. British Journal of Pharmacology © 2011 The

  11. Nanostructured interfaces with site-specific bioreceptors for immunosensing

    Energy Technology Data Exchange (ETDEWEB)

    Paiva, Telmo O.; Almeida, Inês; Marquês, Joaquim T. [Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Edifício C8, 1749-016 Lisboa (Portugal); Liu, Wei [NML, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190 (China); Institute of Microelectronics, Tsinghua University, Beijing 100084 (China); Niu, Yu [NML, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190 (China); Jin, Gang, E-mail: gajin@imech.ac.cn [NML, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190 (China); School of Engineering Science, University of Chinese Academy of Sciences, Beijing 100049 (China); Viana, Ana S., E-mail: anaviana@fc.ul.pt [Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Edifício C8, 1749-016 Lisboa (Portugal)

    2017-08-01

    Highlights: • Innovative and simple strategy to create sensitive immunosensing platforms. • Gold surface modification with dithiocarbamate nanoconjugates of protein A. • CS{sub 2} strongly adsorbed on gold able to block protein nonspecific adsorption. • High performance for antigen detection by properly oriented antibodies. - Abstract: In this work, we propose a simple and effective approach to build nanostructured immunosensor platforms. The one-step strategy relies on i) the in situ formation of dithiocarbamates from the reaction between carbon disulfide and amine groups, present on protein A, ii) their attachment to gold nanoparticles (AuNPs), and iii) the linkage of the modified AuNPs to the electrode surface, which depends on the strong interaction between gold substrates and sulfur moieties. AuNPs and protein A are used to increase the surface coverage of Immunoglobulin G (IgG) and promote the oriented immobilization of the antibodies on the immunosensing interface. The modified gold surfaces with biomolecules were thoroughly characterized by a combination of techniques: UV–vis spectrophotometry, conventional ellipsometry and atomic force microscopy. The immunosensor performance was assessed in real-time, by surface plasmon resonance and by the highly sensitive total internal reflection imaging ellipsometry, through the specific biorecognition between anti-IgG and the immobilized IgG molecules. We demonstrate that the presence of AuNPs improves the sensitivity of the anti-IgG specific detection, whereas the presence of co-adsorbed CS{sub 2} is responsible for blocking the undesired protein nonspecific adsorption to the gold substrate. Overall, we report a simple and innovative one-step method, to chemically modify gold surfaces with protein A and AuNPs, able to specifically detect antigen/antibody interactions with capability of preventing protein nonspecific adsorption.

  12. Detection of virulence-associated genes in pathogenic and commensal avian Escherichia coli isolates.

    Science.gov (United States)

    Paixão, A C; Ferreira, A C; Fontes, M; Themudo, P; Albuquerque, T; Soares, M C; Fevereiro, M; Martins, L; Corrêa de Sá, M I

    2016-07-01

    Poultry colibacillosis due to Avian Pathogenic Escherichia coli (APEC) is responsible for several extra-intestinal pathological conditions, leading to serious economic damage in poultry production. The most commonly associated pathologies are airsacculitis, colisepticemia, and cellulitis in broiler chickens, and salpingitis and peritonitis in broiler breeders. In this work a total of 66 strains isolated from dead broiler breeders affected with colibacillosis and 61 strains from healthy broilers were studied. Strains from broiler breeders were typified with serogroups O2, O18, and O78, which are mainly associated with disease. The serogroup O78 was the most prevalent (58%). All the strains were checked for the presence of 11 virulence genes: 1) arginine succinyltransferase A (astA); ii) E.coli hemeutilization protein A (chuA); iii) colicin V A/B (cvaA/B); iv) fimbriae mannose-binding type 1 (fimC); v) ferric yersiniabactin uptake A (fyuA); vi) iron-repressible high-molecular-weight proteins 2 (irp2); vii) increased serum survival (iss); viii) iron-uptake systems of E.coli D (iucD); ix) pielonefritis associated to pili C (papC); x) temperature sensitive haemaglutinin (tsh), and xi) vacuolating autotransporter toxin (vat), by Multiplex-PCR. The results showed that all genes are present in both commensal and pathogenic E. coli strains. The iron uptake-related genes and the serum survival gene were more prevalent among APEC. The adhesin genes, except tsh, and the toxin genes, except astA, were also more prevalent among APEC isolates. Except for astA and tsh, APEC strains harbored the majority of the virulence-associated genes studied and fimC was the most prevalent gene, detected in 96.97 and 88.52% of APEC and AFEC strains, respectively. Possession of more than one iron transport system seems to play an important role on APEC survival. © 2016 Poultry Science Association Inc.

  13. Algebraic structure of Robinson–Trautman and Kundt geometries in arbitrary dimension

    International Nuclear Information System (INIS)

    Podolský, J; Švarc, R

    2015-01-01

    We investigate the Weyl tensor algebraic structure of a fully general family of D-dimensional geometries that admit a non-twisting and shear-free null vector field k. From the coordinate components of the curvature tensor we explicitly derive all Weyl scalars of various boost weights. This enables us to give a complete algebraic classification of the metrics in the case when the optically privileged null direction k is a (multiple) Weyl aligned null direction (WAND). No field equations are applied, so the results are valid not only in Einstein's gravity, including its extension to higher dimensions, but also in any metric gravitation theory that admits non-twisting and shear-free spacetimes. We prove that all such geometries are of type I(b), or more special, and we derive surprisingly simple necessary and sufficient conditions under which k is a double, triple or quadruple WAND. All possible algebraically special types, including the refinement to subtypes, are thus identified, namely II(a), II(b), II(c), II(d), III(a), III(b), N, O, II i , III i , D, D(a), D(b), D(c), D(d), and their combinations. Some conditions are identically satisfied in four dimensions. We discuss both important subclasses, namely the Kundt family of geometries with the vanishing expansion (Θ=0) and the Robinson–Trautman family (Θ ≠ 0, and in particular Θ=1/r). Finally, we apply Einstein's field equations and obtain a classification of all Robinson–Trautman vacuum spacetimes. This reveals fundamental algebraic differences in the D>4 and D=4 cases, namely that in higher dimensions there only exist such spacetimes of types D(a) ≡ D(abd), D(c) ≡ D(bcd) and O. (paper)

  14. Cryptosporidium spp. and Giardia duodenalis as pathogenic contaminants of water in Galicia, Spain: the need for safe drinking water.

    Science.gov (United States)

    Castro-Hermida, José Antonio; González-Warleta, Marta; Mezo, Mercedes

    2015-01-01

    The objectives of this cross-sectional study were to detect the presence of Cryptosporidium spp. and Giardia duodenalis in drinking water treatments plants (DWTPs) in Galicia (NW Spain) and to identify which species and genotype of these pathogenic protozoans are present in the water. Samples of untreated water (surface or ground water sources) and of treated drinking water (in total, 254 samples) were collected from 127 DWTPs and analysed by an immunofluorescence antibody test (IFAT) and by PCR. Considering the untreated water samples, Cryptosporidium spp. were detected in 69 samples (54.3%) by IFAT, and DNA of this parasite was detected in 57 samples (44.8%) by PCR, whereas G. duodenalis was detected in 76 samples (59.8%) by IFAT and in 56 samples (44.0%) by PCR. Considering the treated drinking water samples, Cryptosporidium spp. was detected in 52 samples (40.9%) by IFAT, and the parasite DNA was detected in 51 samples (40.1%) by PCR, whereas G. duodenalis was detected in 58 samples (45.6%) by IFAT and in 43 samples (33.8%) by PCR. The percentage viability of the (oo)cysts ranged between 90.0% and 95.0% in all samples analysed. Cryptosporidium andersoni, C. hominis, C. parvum and assemblages A-I, A-II, E of G. duodenalis were identified. The results indicate that Cryptosporidium spp. and G. duodenalis are widespread in the environment and that DWTPs are largely ineffective in reducing/inactivating these pathogens in drinking water destined for human and animal consumption in Galicia. In conclusion, the findings suggest the need for better monitoring of water quality and identification of sources of contamination. Copyright © 2014 Elsevier GmbH. All rights reserved.

  15. Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors.

    Science.gov (United States)

    Yang, Guanghua; Si-Tayeb, Karim; Corbineau, Sébastien; Vernet, Rémi; Gayon, Régis; Dianat, Noushin; Martinet, Clémence; Clay, Denis; Goulinet-Mainot, Sylvie; Tachdjian, Gérard; Tachdjian, Gérard; Burks, Deborah; Vallier, Ludovic; Bouillé, Pascale; Dubart-Kupperschmitt, Anne; Weber, Anne

    2013-07-19

    Human pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine. However, the safety of cell therapy using differentiated hPSC derivatives must be improved through methods that will permit the transplantation of homogenous populations of a specific cell type. To date, purification of progenitors and mature cells generated from either embryonic or induced pluripotent stem cells remains challenging with use of conventional methods. We used lentivectors encoding green fluorescent protein (GFP) driven by the liver-specific apoliprotein A-II (APOA-II) promoter to purify human hepatic progenitors. We evaluated both integrating and integration-defective lentivectors in combination with an HIV integrase inhibitor. A human embryonic stem cell line was differentiated into hepatic progenitors using a chemically defined protocol. Subsequently, cells were transduced and sorted at day 16 of differentiation to obtain a cell population enriched in hepatic progenitor cells. After sorting, more than 99% of these APOA-II-GFP-positive cells expressed hepatoblast markers such as α-fetoprotein and cytokeratin 19. When further cultured for 16 days, these cells underwent differentiation into more mature cells and exhibited hepatocyte properties such as albumin secretion. Moreover, they were devoid of vector DNA integration. We have developed an effective strategy to purify human hepatic cells from cultures of differentiating hPSCs, producing a novel tool that could be used not only for cell therapy but also for in vitro applications such as drug screening. The present strategy should also be suitable for the purification of a broad range of cell types derived from either pluripotent or adult stem cells.

  16. The caesium oxygen interactions in the crystalline solids

    International Nuclear Information System (INIS)

    Leclaire, Andre

    2008-01-01

    Through the study of the Cs-O bonds registered in the literature one observes that: (i)the bond lengths range from 2.46 to 3.60 A; (ii)the preferential coordination numbers adopted by the caesium ions are 8, 9 and 10 but values from 1 to 12 also exist; (iii)the average bond lengths increase with the coordination (CN) of the caesium ions with the following values: 2.714 A (CN=1), 2.98 A (CN=2), 3.057 A (CN=3), 3.104 A (CN=4), 3.149 A (CN=5), 3.188 A (CN=6), 3.224 A (CN=7), 3.245 A (CN=8), 3.261 A (CN=9), 3.269 A (CN=10), 3.293 A (CN=11) and 3.323 A (CN=12). A new R ij =2.469 constant is determined with all the caesium coordination polyhedra to compute electrostatic bond valence sums. The U eq values of caesium in crystal structure are about 0.03 and generally less than 0.06 similar to those of the oxygen atoms and often bigger. - Graphical abstract: A survey of more than 1000 of oxygen polyhedrons around caesium ions shows bond lengths ranging from 2.46 to 3.60 A with 32% of the shortest bonds in the polyhedrons less than 3.00 A. Coordination numbers from 1 to 12 are observed, in which the average bond lengths increase from 2.714 to 3.323 A with the coordination, and with a preference for 8, 9 and 10-fold surrounding

  17. Overview of the Life Science Glovebox (LSG) Facility and the Research Performed in the LSG

    Science.gov (United States)

    Cole, J. Michael; Young, Yancy

    2016-01-01

    The Life Science Glovebox (LSG) is a rack facility currently under development with a projected availability for International Space Station (ISS) utilization in the FY2018 timeframe. Development of the LSG is being managed by the Marshal Space Flight Center (MSFC) with support from Ames Research Center (ARC) and Johnson Space Center (JSC). The MSFC will continue management of LSG operations, payload integration, and sustaining following delivery to the ISS. The LSG will accommodate life science and technology investigations in a "workbench" type environment. The facility has a.Ii enclosed working volume that is held at a negative pressure with respect to the crew living area. This allows the facility to provide two levels of containment for handling Biohazard Level II and lower biological materials. This containment approach protects the crew from possible hazardous operations that take place inside the LSG work volume. Research investigations operating inside the LSG are provided approximately 15 cubic feet of enclosed work space, 350 watts of28Vdc and l IOVac power (combined), video and data recording, and real time downlink. These capabilities will make the LSG a highly utilized facility on ISS. The LSG will be used for biological studies including rodent research and cell biology. The LSG facility is operated by the Payloads Operations Integration Center at MSFC. Payloads may also operate remotely from different telescience centers located in the United States and different countries. The Investigative Payload Integration Manager (IPIM) is the focal to assist organizations that have payloads operating in the LSG facility. NASA provides an LSG qualification unit for payload developers to verify that their hardware is operating properly before actual operation on the ISS. This poster will provide an overview of the LSG facility and a synopsis of the research that will be accomplished in the LSG. The authors would like to acknowledge Ames Research Center, Johnson

  18. Six rapid tests for direct detection of Clostridium difficile and its toxins in fecal samples compared with the fibroblast cytotoxicity assay.

    Science.gov (United States)

    Turgeon, David K; Novicki, Thomas J; Quick, John; Carlson, LaDonna; Miller, Pat; Ulness, Bruce; Cent, Anne; Ashley, Rhoda; Larson, Ann; Coyle, Marie; Limaye, Ajit P; Cookson, Brad T; Fritsche, Thomas R

    2003-02-01

    Clostridium difficile is one of the most frequent causes of nosocomial gastrointestinal disease. Risk factors include prior antibiotic therapy, bowel surgery, and the immunocompromised state. Direct fecal analysis for C. difficile toxin B by tissue culture cytotoxin B assay (CBA), while only 60 to 85% sensitive overall, is a common laboratory method. We have used 1,003 consecutive, nonduplicate fecal samples to compare six commercially available immunoassays (IA) for C. difficile detection with CBA: Prima System Clostridium difficile Tox A and VIDAS Clostridium difficile Tox A II, which detect C. difficile toxin A; Premier Cytoclone A/B and Techlab Clostridium difficile Tox A/B, which detect toxins A and B; and ImmunoCard Clostridium difficile and Triage Micro C. difficile panels, which detect toxin A and a species-specific antigen. For all tests, Triage antigen was most sensitive (89.1%; negative predictive value [NPV] = 98.7%) while ImmunoCard was most specific (99.7%; positive predictive value [PPV] = 95.0%). For toxin tests only, Prima System had the highest sensitivity (82.2%; NPV = 98.0%) while ImmunoCard had the highest specificity (99.7%; PPV = 95.0%). Hematopoietic stem cell transplant (HSCT) patients contributed 44.7% of all samples tested, and no significant differences in sensitivity or specificity were noted between HSCT and non-HSCT patients. IAs, while not as sensitive as direct fecal CBA, produce reasonable predictive values, especially when both antigen and toxin are detected. They also offer significant advantages over CBA in terms of turnaround time and ease of use.

  19. Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice

    Directory of Open Access Journals (Sweden)

    J. A. Lenzi

    1987-01-01

    Full Text Available Modification of the immune response to schistosomal infection in children or offspring born to mother R infected with Schistosoma mansoni has been demonstrated in human and in experimental schistosomiasis. One of the hypothesis to explain this fact could be the transfer of circulating antigens and antibodies from mother to foetus through the placenta or from mother to child by milk. The results of this spontaneous transference are controversial in the literature. In an attempt to investigate these questions, we studied one hundred and twenty offspring (Swiss mice, sixty born to infected-mothers (group A and sixty born to non-infected mothers (group B. These were percutaneously infected with 50 cercariae/mouse, and divided in six sub-groups (20 mice/sub-group, according to the following schedule: after birth (sub-groups A.I and B.I, 10 days old (sub-groups A.II and B.II and 21 days old (sub-groups A.III and B.III. After the exposure period, the young mice returned to their own mothers for nursing. Six weeks later, the mice were killed. We obtained the following results: 1 There is transference of antibody to cercariae (CAP, adult worms (SWAP and egg antigens (SEA from the infected mothers to the offspring, probably through placenta and milk; 2 Offspring born to infected mothers exhibit much less coagulative hepatic necrosis and show a lower number of eggs in the small intestine and a less intense and predominant exsudative stage of the hepatic granulomas when compared with the exsudative-productive stage of the control groups. The findings suggest that congenital and nursing factors can interfere on the development of the schistosomiasis infection, causing an hyporesponse to the eggs.

  20. Effects of 17β-estradiol and 2-methoxyestradiol on the oxidative stress-hypoxia inducible factor-1 pathway in hypoxic pulmonary hypertensive rats.

    Science.gov (United States)

    Wang, Li; Zheng, Quan; Yuan, Yadong; Li, Yanpeng; Gong, Xiaowei

    2017-05-01

    The present study aimed to investigate the effects of 17β-estradiol (E2) and 2-methoxyestradiol (2ME) on the oxidative stress-hypoxia inducible factor-1 (OS-HIF-1) pathway in hypoxic pulmonary hypertensive rats. Female Sprague-Dawley rats were divided randomly into 4 groups, as follows: i) Control (Group A); ii) ovariectomy (OVX) + hypoxia (Group B); iii) OVX + hypoxia + E2 injection (Group C); and iv) 2ME injection (Group D). The rats were maintained under hypoxic conditions for 8 weeks, and mean pulmonary artery pressure (mPAP) and pulmonary arteriole morphology were measured. The reactive oxygen species, superoxide dismutase (SOD), manganese superoxide dismutase (MnSOD), and copper-zinc superoxide dismutase (Cu/ZnSOD) levels in serum were also measured. MnSOD and HIF-1α expression levels in lung tissue were determined by western blotting and reverse transcription-quantitative polymerase chain reaction. The mPAP and arterial remodeling index were significantly elevated following chronic hypoxia exposure; however, experimental data revealed a reduced response in E2 and 2ME intervention rats. Compared with Group A, Group B had significantly elevated oxidative stress levels, as illustrated by increased serum ROS levels, decreased serum SOD and MnSOD levels and decreased MnSOD mRNA and protein expression levels in lung tissue. Furthermore, HIF-1α mRNA and protein expression in Group B was significantly elevated compared with Group A. E2 and 2ME intervention significantly attenuated the aforementioned parameter changes, suggesting that E2 and 2ME partially ameliorate hypoxic pulmonary hypertension. The underlying mechanism of this may be associated with the increase in MnSOD activity and expression and reduction in ROS level, which reduces the levels of transcription and translation of HIF-1α.

  1. Additional physical access and new technologies for strengthened safeguards

    International Nuclear Information System (INIS)

    Tuley, N.

    1999-01-01

    For States with additional protocols, the Agency may request complementary access for any of the following reasons: (a) to ensure the absence of undeclared nuclear material and activities at sites of facilities or locations outside facilities (LOFs) or at other locations declared under Article 2 as containing nuclear material (Article 4.a.i); (b) to resolve a question relating to the correctness and completeness of the information provided pursuant to Article 2 or to resolve an inconsistency relating to that information (Article 4.a.ii); and (c) to confirm, for safeguards purposes, the State's declaration of the decommissioned status of a facility or of a LOF where nuclear material was used (Article 4.a.iii). Under additional protocols, the activities that the Agency may carry out in a State include visual observation, environmental sampling and non-destructive measurement. Agency guidelines for complementary access are being developed. In the late 1980s and in the 1990s, new technologies became available enabling the IAEA to detect even minute trace indicators of various types of nuclear activities. This technique which is known as environmental sampling, contributes to the confirmation of the absence of undeclared nuclear material or nuclear activities. Collection of environmental samples at or near a nuclear site combined with ultra-sensitive analytical techniques can reveal signatures of post and current activities in locations where nuclear material is being handled. Another important new technology is remote monitoring which makes use of unattended safeguards instrument systems and ships off-site the data gathered from those instruments to IAEA Headquarters. Cost effectiveness is a prime justification for adding this feature to unattended monitoring systems such as optical surveillance and advanced optical seals. (author)

  2. Elevated plasma low-density lipoprotein and high-density lipoprotein cholesterol levels in amenorrheic athletes: effects of endogenous hormone status and nutrient intake.

    Science.gov (United States)

    Friday, K E; Drinkwater, B L; Bruemmer, B; Chesnut, C; Chait, A

    1993-12-01

    To determine the interactive effects of hormones, exercise, and diet on plasma lipids and lipoproteins, serum estrogen and progesterone levels, nutrient intake, and plasma lipid, lipoprotein, and apolipoprotein concentrations were measured in 24 hypoestrogenic amenorrheic and 44 eumenorrheic female athletes. When compared to eumenorrheic athletes, amenorrheic athletes had higher levels of plasma cholesterol (5.47 +/- 0.17 vs. 4.84 +/- 0.12 mmol/L, P = 0.003), triglyceride (0.75 +/- 0.06 vs. 0.61 +/- 0.03 mmol/L, P = 0.046), low-density lipoprotein (LDL; 3.16 +/- 0.15 vs. 2.81 +/- 0.09 mmol/L, P = 0.037), high-density lipoprotein (HDL; 1.95 +/- 0.07 vs. 1.73 +/- 0.05 mmol/L, P = 0.007), and HDL2 (0.84 +/- 0.06 vs. 0.68 +/- 0.04 mmol/L, P = 0.02) cholesterol. Plasma LDL/HDL cholesterol ratios, very low-density lipoprotein and HDL3 cholesterol, and apolipoprotein A-I and A-II levels were similar in the two groups. Amenorrheic athletes consumed less fat than eumenorrheic subjects (52 +/- 5 vs. 75 +/- 3 g/day, P = 0.02), but similar amounts of calories, cholesterol, protein, carbohydrate, and ethanol. HDL cholesterol levels in amenorrheic subjects correlated positively with the percent of dietary calories from fat (r = 0.42, n = 23, P = 0.045) but negatively with the percent from protein (r = -0.49, n = 23, P = 0.017). Thus, exercise-induced amenorrhea may adversely affect cardiovascular risk by increasing plasma LDL and total cholesterol. However, cardioprotective elevations in plasma HDL and HDL2 cholesterol may neutralize the risk of cardiovascular disease in amenorrheic athletes.

  3. Preparation, conduct and evaluation of exercises to test preparedness for a nuclear or radiological emergency. Emergency preparedness and response

    International Nuclear Information System (INIS)

    2005-04-01

    The aim of this publication is to serve as a practical tool for the preparation, conduct and evaluation of exercises to test preparedness for response to a nuclear or radiological emergency. It fulfils in part the functions assigned to the IAEA under Article 5.a(ii) of the Convention on Assistance in Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), namely, to collect and disseminate to States Parties and Member States information concerning the methodologies, techniques and available results of research on such emergencies. To ensure effective response to radiation emergencies when needed, provisions should be made for regular training of emergency response personnel. As stated in Preparedness and Response for a Nuclear or Radiological Emergency (Safety Requirements, Safety Standard Series No. GS-R-2), 'The operator and the response organizations shall make arrangements for the selection of personnel and training to ensure that the personnel have the requisite knowledge, skills, abilities, equipment, procedures and other arrangements to perform their assigned response functions'. A further requirement is that 'Exercise programmes shall be conducted to ensure that all specified functions required to be performed for emergency response and all organizational interfaces for facilities in threat category I, II or III and the national level programmes for threat category IV or V are tested at suitable intervals'. In 2004 the IAEA General Conference, in resolution GC(48)/RES/10 encouraged Member States to 'implement the Safety Requirements for Preparedness and Response to a Nuclear or Radiological Emergency'. This document is published as part of the IAEA Emergency Preparedness and Response Series to assist in meeting these requirements and to fulfil Article 5 of the Assistance Convention. It was developed based on a number of assumptions about national and local capabilities. Therefore, the exercise structure, terms and scenarios must be

  4. Seismic stratigraphy of the Heuksan mud belt in the southeastern Yellow Sea, Korea

    Science.gov (United States)

    Lee, Gwang-Soo; Yoo, Dong Geun; Bae, Sung Ho; Min, Gun-Hong; Kim, Seong-Pil; Choi, Hunsoo

    2015-12-01

    To establish the seismic stratigraphy of the Heuksan mud belt (HMB) and reconstruct its depositional history, approximately 1,600 km of high-resolution seismic data were newly obtained using chirp acoustic sub-bottom profiler, sparker, and air-gun seismic systems. Based on seismic stratigraphic analysis, the HMB can be divided into three major seismic units (I, II, and III, from top to bottom) and four subunits (II-a, II-b, III-a, and III-b) overlying transgressive sands, pre-last glacial maximum (LGM) deposits, and the acoustic basement. Each unit and subunit show different seismic facies and geometry, being clearly separated from each other by bounding surfaces formed since the LGM. The spatial distribution, thicknesses and volumes of the seismic units were determined and plotted to document the sequential formation of the HMB. The correlation between deep drill core data (HMB-101, HMB-102, HMB-103, YSDP-101, and YSDP-102) and the seismic data suggests that subunits III-b and III-a were formed by the continuous accumulation of fine-grained sediment with partial sandy sediment in an estuarine/deltaic environment during the early to middle transgressive stage, accompanied by landward migration of the shoreline. Subunits II-b and II-a were probably formed by re-deposition of large volumes of sediment eroded from unit III during the middle transgressive to early highstand stage. Unit I is interpreted as the most recent mud deposit representing the highstand systems tract when sea-level rise terminated. The careful definition of seismic units and their interpretation proposed in this study, on the basis of the large and partly new seismic dataset covering the entire HMB together with deep drill core data, have been instrumental in reconstructing the depositional environment and formation mechanisms of the HMB.

  5. Hyperosmotic nanoemulsions: Development and application of a new antimicrobial treatment for wound care

    Science.gov (United States)

    Connell, Sean

    Wound healing is the intricate process that restores function to damaged skin. The process consists of the inflammatory, proliferative and remodeling phases that orchestrate dynamic cellular responses to regenerate the cutaneous barrier. However, microbial contamination of the wound site stimulates a deleterious inflammatory response with the production of endotoxins, exotoxins and proteases that result in secondary injury. The end result is delayed healing, protracted debilitation and increased health care costs. Controlling contamination is critical for proper wound management and reduced burden on the healthcare system. Based on this concern, we developed and applied a new antimicrobial therapeutic that relies on hyperosmotic nanoemulsions (HNE). The biomechanical process consists of a high-energy nanoemulsion component that permeates the protective microbial membrane and a (ii) nonionic hyperosmoticum that facilitates intracellular water extraction to critically dehydrate the pathogen. HNE was shown to be effective against a multitude of pathogens including bacteria, antibiotic-resistant variants, fungi and viruses. Reported non-clinical studies demonstrate that the membrane disrupting nanoemulsion and hyperosmotic component act synergistically to enhance microbicidal activity. Further, results illustrate that pathogen inactivation was rapid as determined by ion and macromolecule leakage assays. Application of HNE in a pre-clinical animal model of wound healing demonstrated the treatment actively promoted healing to reduce treatment times. HNE mitigated wound infection to reduce the inflammatory response and mechanically debrided the wound to facilitate wound closure. Recent work further enhanced the stability of the nanoemulsion component with the addition of surfactant stabilizers using a low-energy spontaneous emulsification process. The refined nanoemulsion composition was stable against physical stressors and long-term storage without disrupting the

  6. Release of antibiotics from collagen dressing.

    Science.gov (United States)

    Grzybowski, J; Antos-Bielska, M; Ołdak, E; Trafny, E A

    1997-01-01

    Our new collagen dressing has been developed recently. Three types (A, B, and C) of the dressing were prepared in this study. Each type contained bacitracin, neomycin or colistin. The antibiotic was input into: i. collagen sponge (CS)--type A, ii. layer of limited hydrophobicity (LLH)--type B, and iii. into both CS and LLH layers--type C. The final concentration of the antibiotic that resulted from the loading level was 2 mg/cm2 for the dressings of type A and B and 4 mg/cm2 for the dressing of type C. The antibiotics were then extracted from the pieces of dressings for two days through dialysis membrane. Susceptibility of 54 bacterial strains (S. aureus, P. aeruginosa, and Acinetobacter) isolated from burn wounds were tested to the three antibiotics used for preparation of the dressings. The results of the study evidenced that efficiency of released of antibiotics into the extracts depended on the kind of antibiotic and on the type of dressing. The concentration of the antibiotics proved to be much higher than MIC90 values of the bacterial isolates tested in respect to their susceptibility. The dressing containing mixture of the three antibiotics in two layers--CS and LLH is now considered as potentially effective for care of infected wounds. It may be useful for the treatment of infected wounds or for profilaxis of contaminated wounds, ensuring: i. sufficient antimicrobial activity in wound, and ii. optimal wound environment for the presence of collagenic biomaterial on the damaged tissue.

  7. Rerouting of carbon flux in a glycogen mutant of cyanobacteria assessed via isotopically non-stationary 13 C metabolic flux analysis.

    Science.gov (United States)

    Hendry, John I; Prasannan, Charulata; Ma, Fangfang; Möllers, K Benedikt; Jaiswal, Damini; Digmurti, Madhuri; Allen, Doug K; Frigaard, Niels-Ulrik; Dasgupta, Santanu; Wangikar, Pramod P

    2017-10-01

    Cyanobacteria, which constitute a quantitatively dominant phylum, have attracted attention in biofuel applications due to favorable physiological characteristics, high photosynthetic efficiency and amenability to genetic manipulations. However, quantitative aspects of cyanobacterial metabolism have received limited attention. In the present study, we have performed isotopically non-stationary 13 C metabolic flux analysis (INST- 13 C-MFA) to analyze rerouting of carbon in a glycogen synthase deficient mutant strain (glgA-I glgA-II) of the model cyanobacterium Synechococcus sp. PCC 7002. During balanced photoautotrophic growth, 10-20% of the fixed carbon is stored in the form of glycogen via a pathway that is conserved across the cyanobacterial phylum. Our results show that deletion of glycogen synthase gene orchestrates cascading effects on carbon distribution in various parts of the metabolic network. Carbon that was originally destined to be incorporated into glycogen gets partially diverted toward alternate storage molecules such as glucosylglycerol and sucrose. The rest is partitioned within the metabolic network, primarily via glycolysis and tricarboxylic acid cycle. A lowered flux toward carbohydrate synthesis and an altered distribution at the glucose-1-phosphate node indicate flexibility in the network. Further, reversibility of glycogen biosynthesis reactions points toward the presence of futile cycles. Similar redistribution of carbon was also predicted by Flux Balance Analysis. The results are significant to metabolic engineering efforts with cyanobacteria where fixed carbon needs to be re-routed to products of interest. Biotechnol. Bioeng. 2017;114: 2298-2308. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  8. New tools for chloroplast genetic engineering allow the synthesis of human growth hormone in the green alga Chlamydomonas reinhardtii.

    Science.gov (United States)

    Wannathong, Thanyanan; Waterhouse, Janet C; Young, Rosanna E B; Economou, Chloe K; Purton, Saul

    2016-06-01

    In recent years, there has been an increasing interest in the exploitation of microalgae in industrial biotechnology. Potentially, these phototrophic eukaryotes could be used for the low-cost synthesis of valuable recombinant products such as bioactive metabolites and therapeutic proteins. The algal chloroplast in particular represents an attractive target for such genetic engineering, both because it houses major metabolic pathways and because foreign genes can be targeted to specific loci within the chloroplast genome, resulting in high-level, stable expression. However, routine methods for chloroplast genetic engineering are currently available only for one species-Chlamydomonas reinhardtii-and even here, there are limitations to the existing technology, including the need for an expensive biolistic device for DNA delivery, the lack of robust expression vectors, and the undesirable use of antibiotic resistance markers. Here, we describe a new strain and vectors for targeted insertion of transgenes into a neutral chloroplast locus that (i) allow scar-less fusion of a transgenic coding sequence to the promoter/5'UTR element of the highly expressed endogenous genes psaA or atpA, (ii) employ the endogenous gene psbH as an effective but benign selectable marker, and (iii) ensure the successful integration of the transgene construct in all transformant lines. Transformation is achieved by a simple and cheap method of agitation of a DNA/cell suspension with glass beads, with selection based on the phototrophic rescue of a cell wall-deficient ΔpsbH strain. We demonstrate the utility of these tools in the creation of a transgenic line that produces high levels of functional human growth hormone.

  9. Structural peculiarities and point defects of bulk-ZnO single crystals

    International Nuclear Information System (INIS)

    Kaurova, I.A.; Kuz’micheva, G.M.; Rybakov, V.B.; Cousson, A.; Gayvoronsky, V.Ya.

    2014-01-01

    Highlights: • ZnO single crystals of different color were grown by the hydrothermal method. • Point defects in ZnO have been firstly investigated by neutron diffraction. • Presence of additional reflections caused by kinetic growth effects was revealed. • The relationship between the color and zinc and oxygen vacancies was found. • Photoinduced variation of transmittance versus the CW laser intensity was analyzed. - Abstract: ZnO single crystals are related to promising direct wide band gap semiconductor materials belonging to the A II B VI type of compounds with wurtzite structure. “Unintentional” n-type conductivity in ZnO may be caused by zinc and oxygen vacancies, and interstitial zinc atoms. To date, the comprehensive structural investigation and analysis of point defects in ZnO is absent in literature. Green, light green and almost colorless ZnO single crystals grown by the hydrothermal method in concentrated alkali solutions 4M(KOH) + 1M(LiOH) + 0.1M(NH 4 OH) on monohedral seeds [0 0 0 1] at crystallization temperatures in the range of 330–350 °C and pressures in the range of 30–50 MPa have been firstly investigated by neutron diffraction. It was revealed the presence of additional reflections (∼12–∼16%) for all the crystals caused by kinetic growth effects that give grounds to assign them to the space group P3 rather than to P6 3 mc. Analysis of the refined compositions together with the color of ZnO crystals does not rule out the relationship between the color and vacancies in the zinc and oxygen positions whose concentration decreases with the discoloration of the samples. The analysis of the photoinduced variation of the total and on-axis transmittance versus the CW laser intensity showed that the colored samples have profound deep defects related to oxygen vacancies

  10. Differential expression of P-type ATPases in intestinal epithelial cells: Identification of putative new atp1a1 splice-variant

    Energy Technology Data Exchange (ETDEWEB)

    Rocafull, Miguel A., E-mail: mrocaful@ivic.ve [Lab. Fisiologia Molecular, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 20632, Caracas 1020-A (Venezuela, Bolivarian Republic of); Thomas, Luz E.; Barrera, Girolamo J.; Castillo, Jesus R. del [Lab. Fisiologia Molecular, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 20632, Caracas 1020-A (Venezuela, Bolivarian Republic of)

    2010-01-01

    P-type ATPases are membrane proteins that couple ATP hydrolysis with cation transport across the membrane. Ten different subtypes have been described. In mammalia, 15 genes of P-type ATPases from subtypes II-A, II-B and II-C, that transport low-atomic-weight cations (Ca{sup 2+}, Na{sup +}, K{sup +} and H{sup +}), have been reported. They include reticulum and plasma-membrane Ca{sup 2+}-ATPases, Na{sup +}/K{sup +}-ATPase and H{sup +}/K{sup +}-ATPases. Enterocytes and colonocytes show functional differences, which seem to be partially due to the differential expression of P-type ATPases. These enzymes have 9 structural motifs, being the phosphorylation (E) and the Mg{sup 2+}ATP-binding (H) motifs the most preserved. These structural characteristics permitted developing a Multiplex-Nested-PCR (MN-PCR) for the simultaneous identification of different P-type ATPases. Thus, using MN-PCR, seven different cDNAs were cloned from enterocytes and colonocytes, including SERCA3, SERCA2, Na{sup +}/K{sup +}-ATPase {alpha}1-isoform, H{sup +}/K{sup +}-ATPase {alpha}2-isoform, PMCA1, PMCA4 and a cDNA-fragment that seems to be a new cassette-type splice-variant of the atp1a1 gen. PMCA4 in enterocytes and H{sup +}/K{sup +}-ATPase {alpha}2-isoform in colonocytes were differentially expressed. This cell-specific expression pattern is related with the distinctive enterocyte and colonocyte functions.

  11. Evolution and ecophysiology of the industrial producer Hypocrea jecorina (Anamorph Trichoderma reesei and a new sympatric agamospecies related to it.

    Directory of Open Access Journals (Sweden)

    Irina S Druzhinina

    Full Text Available BACKGROUND: Trichoderma reesei, a mitosporic green mould, was recognized during the WW II based on a single isolate from the Solomon Islands and since then used in industry for production of cellulases. It is believed to be an anamorph (asexual stage of the common pantropical ascomycete Hypocrea jecorina. METHODOLOGY/PRINCIPAL FINDINGS: We combined molecular evolutionary analysis and multiple methods of phenotype profiling in order to reveal the genetic relationship of T. reesei to H. jecorina. The resulting data show that the isolates which were previously identified as H. jecorina by means of morphophysiology and ITS1 and 2 (rRNA gene cluster barcode in fact comprise several species: i H. jecorina/T. reesei sensu stricto which contains most of the teleomorphs (sexual stages found on dead wood and the wild-type strain of T. reesei QM 6a; ii T. parareesei nom. prov., which contains all strains isolated as anamorphs from soil; iii and two other hypothetical new species for which only one or two isolates are available. In silico tests for recombination and in vitro mating experiments revealed a history of sexual reproduction for H. jecorina and confirmed clonality for T. parareesei nom. prov. Isolates of both species were consistently found worldwide in pantropical climatic zone. Ecophysiological comparison of H. jecorina and T. parareesei nom. prov. revealed striking differences in carbon source utilization, conidiation intensity, photosensitivity and mycoparasitism, thus suggesting adaptation to different ecological niches with the high opportunistic potential for T. parareesei nom. prov. CONCLUSIONS: Our data prove that T. reesei belongs to a holomorph H. jecorina and displays a history of worldwide gene flow. We also show that its nearest genetic neighbour--T. parareesei nom. prov., is a cryptic phylogenetic agamospecies which inhabits the same biogeographic zone. These two species thus provide a so far rare example of sympatric speciation

  12. Inactivation of enterohemorrhagic Escherichia coli in rumen content- or feces-contaminated drinking water for cattle.

    Science.gov (United States)

    Zhao, Tong; Zhao, Ping; West, Joe W; Bernard, John K; Cross, Heath G; Doyle, Michael P

    2006-05-01

    Cattle drinking water is a source of on-farm Escherichia coli O157:H7 transmission. The antimicrobial activities of disinfectants to control E. coli O157:H7 in on-farm drinking water are frequently neutralized by the presence of rumen content and manure that generally contaminate the drinking water. Different chemical treatments, including lactic acid, acidic calcium sulfate, chlorine, chlorine dioxide, hydrogen peroxide, caprylic acid, ozone, butyric acid, sodium benzoate, and competing E. coli, were tested individually or in combination for inactivation of E. coli O157:H7 in the presence of rumen content. Chlorine (5 ppm), ozone (22 to 24 ppm at 5 degrees C), and competing E. coli treatment of water had minimal effects (rumen content at water-to-rumen content ratios of 50:1 (vol/wt) and lower. Four chemical-treatment combinations, including (i) 0.1% lactic acid, 0.9% acidic calcium sulfate, and 0.05% caprylic acid (treatment A); (ii) 0.1% lactic acid, 0.9% acidic calcium sulfate, and 0.1% sodium benzoate (treatment B); (iii) 0.1% lactic acid, 0.9% acidic calcium sulfate, and 0.5% butyric acid (treatment C); and (iv) 0.1% lactic acid, 0.9% acidic calcium sulfate, and 100 ppm chlorine dioxide (treatment D); were highly effective (>3 log CFU/ml reduction) at 21 degrees C in killing E. coli O157:H7, O26:H11, and O111:NM in water heavily contaminated with rumen content (10:1 water/rumen content ratio [vol/wt]) or feces (20:1 water/feces ratio [vol/wt]). Among them, treatments A, B, and C killed >5 log CFU E. coli O157:H7, O26:H11, and O111:NM/ml within 30 min in water containing rumen content or feces, whereas treatment D inactivated approximately 3 to 4 log CFU/ml under the same conditions. Cattle given water containing treatment A or C or untreated water (control) ad libitum for two 7-day periods drank 15.2, 13.8, and 30.3 liters/day, respectively, and cattle given water containing 0.1% lactic acid plus 0.9% acidic calcium sulfate (pH 2.1) drank 18.6 liters/day. The

  13. Training of support afferentation in postmenopausal women.

    Science.gov (United States)

    Bazanova, O M; Kholodina, N V; Nikolenko, E D; Payet, J

    2017-12-01

    We have recently shown a diminishing of the Menopause Index in old-aged women who underwent special training directed at the enhancement of support afferentation by increasing the plantar forefoot sensitivity (Bazanova et al., 2015). Based on these results we hypothesized, that purposeful training of support afferentation through stimulation of plantar graviceptors by Aikido practice will decrease excessive postural and psychoemotional tension not only in rest condition, but during cognitive and manual task performance too. Fluency of cognitive and motor task performance, EEG alpha power as an index of neuronal efficiency of cognitive control, amount of alpha power suppression as a visual activation measure and EMG power of forehead muscles as a sign of psychoemotional tension were compared in three groups of post-menopausal women: i) 8years training with forefeet support afferentation with Aikido practice (A), ii) 8years fitness training (F) and iii) no dedicated fitness training for past 8years (N). Simultaneous stabilometry, EEG, and frontal EMG recording were performed in sitting and standing up position in eyes closed and eyes open condition. Recording done at rest and while performing cognitive and finger motor tasks. We compared studied parameters between groups with one- and two-way analyses of variance (ANOVAs) with Bonferroni correction for multiple comparisons, followed by post hoc two-tailed unpaired t-tests. The fluency of tasks performance, EMG and alpha-EEG-activity displayed similar values in all groups in a sitting position. Center of pressure (CoP) sway length, velocity and energy demands for saving balance increased when standing up, more in group N than in groups F and A (all contrasts p values0.89). Post hoc t-tests showed increased fluency in standing in both Aikido (p0.77). Fluency in motor task and alpha EEG power decreased, but frontal EMG power increased in response to standing in untrained women (group N) and did not change in F group

  14. A reforma do setor elétrico no Brasil, Argentina e México: contrastes e perspectivas em debate

    Directory of Open Access Journals (Sweden)

    Alessandro André Leme

    2009-06-01

    Full Text Available A década de 1990 foi marcada por um movimento global de Reformas do Estado, principalmente nos países em desenvolvimento. Nesse processo, as orientações das agências multilaterais fizeram-se mais presentes. O conjunto de reformas liberalizantes transferiu para o setor privado setores até então em mãos do Estado. Dentre esses setores destacamos o caso da infra-estrutura energética. O setor elétrico no Brasil, na Argentina e no México consolidou-se após a II Guerra Mundial, sendo majoritariamente ligado ao Estado. Na década de 1990, nesses três países, esse setor passa por mudanças privatizantes. O quadro de fundo (plano político-econômico era muito similar entre os países, embora preservassem particularidades econômicas e político-institucionais. A crise de hiperinflação na década de 1980 e as fortes pressões dos organismos multilaterais para a realização de reformas para o mercado (privatização e flexibilização, dentre outros aspectos levou a mudanças no setor elétrico desses países. Partimos, neste trabalho, de uma abordagem histórico-estrutural e estratégica. Analisamos as reformas no setor elétrico brasileiro em diálogo com as ocorridas na Argentina e no México. Concluímos definindo as principais semelhanças e diferenças entre as políticas liberalizantes do setor elétrico no Brasil, Argentina e México e delimitamos os principais fatores dessas variações, ressaltando a não existência de unicidade histórica na escolhas de estratégias, mas sim composição de estratégias de desenvolvimento decorrentes do embate entre as diversas forças políticas presentes e atuantes num determinado espaço (Estado com suas variantes nacionais e internacionais.

  15. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  16. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme. Publication Date: June 2013 (French Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  17. Actions to Protect the Public in an Emergency due to Severe Conditions at a Light Water Reactor. Date Effective: May 2013 (Russian Edition)

    International Nuclear Information System (INIS)

    2015-01-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the 'Assistance Convention'), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to a nuclear or radiological emergency. This publication is intended to help fulfil in part these functions assigned to the IAEA in the Assistance Convention. The aim of this publication is to provide those persons who are responsible for making and for acting on decisions in the event of an emergency at a light water reactor with an understanding of the actions that are necessary to protect the public. The publication provides a basis for developing the tools and criteria at the preparedness stage that would be needed in taking protective actions and other actions in response to such an emergency. The publication applies the safety principles stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and it will be of assistance to Member States in meeting the requirements established in IAEA Safety Standards Series No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. The application of these requirements is intended to minimize the consequences for people and the environment in any nuclear or radiological emergency. This guidance should be adapted to fit the State's organizational arrangements, language, terminology, concept of operation and capabilities. The IAEA General Conference, in resolution GC(55)/RES/9: 'Emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the Agency's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for

  18. Manual for first responders to a radiological emergency. Emergency preparedness and response. Publication date: June 2007

    International Nuclear Information System (INIS)

    2007-08-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. As stated in IAEA Safety Standards Series No. GS-R-2 'Preparedness and Response for a Nuclear or Radiological Emergency', which establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, 'first responders shall take all practicable and appropriate actions to minimize the consequences of a nuclear or radiological emergency'. The IAEA General Conference, in resolution GC(49)/RES/9, continues to encourage Member States 'to adopt the relevant Agency standards, procedures and practical tools' and underlines 'the need for first responders to have appropriate training for dealing with ionizing radiation during nuclear and radiological emergencies'. This publication is intended to assist in meeting these requirements and to fulfil Article 5 of the Assistance Convention. Its aim is to provide practical guidance for those who will respond during the first few hours to a radiological emergency (referred to here as 'first responders') and for national officials who would support this early response. It provides guidance in the form of action guides, instructions, and supporting data that can be easily applied by a State to build a basic capability to respond to a radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This report, published as part of the IAEA Emergency Preparedness and Response Series, replaces and builds on IAEA-TECDOC-1162 in the area of early response and first responders' actions. It takes account of the

  19. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (Spanish Edition); Comunicacion con el publico en caso de emergencia nuclear o radiologica. Preparacion y respuesta en caso de emergenicia

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-04-15

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  20. Chemické úlohy se školními měřicími systémy: motivační orientace žáků v badatelsky orientovaných úlohách

    Directory of Open Access Journals (Sweden)

    Petr Šmejkal

    2016-07-01

    Questionnaire (MSLQ a (ii Intrinsic Motivation Inventory (IMI. Dotazníky byly statisticky zpracovány – analýzou úrovně reliability (Cronbachovo alfa, analýzou rozptylu (jednoprůchodová ANOVA a shlukovou analýzou. Výsledky ukázaly, že většina žáků byla již před laboratorní prací dostatečně motivována, jejich motivace se po realizaci cvičení ještě zvýšila. Studované aktivity byly hodnoceny nadprůměrně, zvláště pak ty, které se vztahovaly bezprostředně k lidskému tělu (účinnost antacid či medializovaným tématům (plynová chromatografie – methanolová aféra. Analýza rozptylu pak ukázala, že ze sledovatelných faktorů ovlivňující motivační orientace žáků je převážně škola, kterou žák navštěvuje, a potažmo učitel chemie. Naopak, minimálně ovlivňuje motivační orientace pohlaví či realizovaná aktivita. Práce na aktivitách a se školními měřicími systémy žáky ve většině bavila a celkově lze říci, že žáci jsou nakloněni implementaci měřicích systémů do výuky, které tak mají ve výuce přírodních věd nepochybně své místo.

  1. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (Chinese Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  2. Thermal Expansivity Between 150 and 800°C of Hydrothermally Altered Conduit Dyke Samples from USDP-4 Drill Core (Mt Unzen, Shimabara, Japan)

    Science.gov (United States)

    Yilmaz, T. I.; Hess, K. U.; Vasseur, J.; Wadsworth, F. B.; Gilg, H. A.; Nakada, S.; Dingwell, D. B.

    2017-12-01

    When hot magma intrudes the crust, the surrounding rocks expand. Similarly, the cooling magma contracts. The expansion and contraction of these multiphase materials is not simple and often requires empirical constraint. Therefore, we constrained the thermal expansivity of Unzen dome and conduit samples using a NETZSCH® DIL 402C. Following experiments, those samples were scanned using a Phoenix v|tome|x m to observe the cracks that may have developed during the heating and cooling. The dome samples do not show petrological or chemical signs of alteration. However, the alteration of the conduit dykes is represented by the occurrence of the main secondary phases such as chlorite, sulfides, carbonates, R1 (Reichweite parameter) illite-smectite, and kaolinite. These alteration products indicate an (I) early weak to moderate argillic magmatic alteration, and a (II) second stage weak to moderate propylitic hydrothermal alteration. The linear thermal expansion coefficient aL of the dome material is K-1 between 150° and 800°C and shows a sharp peak of up to K-1 around the alpha-beta-quartz-transition ( 573°C). In contrast, aL of the hydrothermally altered conduit samples starts to increase around 180° and reaches K-1 at 400°C. We interpret this effect as being due to the water content of the kaolinite and the R1 illite-smectite, which induces larger expansions per degree temperature change. Furthermore, the altered conduit samples show a more pronounced increases of aL between 500 and 650°C of up to peaks at K-1, which is generated by the breakdown of chlorite, iron-rich dolomite solid solutions, calcite, and pyrite. We use a 1D conductive model of heat transfer to explore how the country rock around the Unzen conduit zone would heat up after intrusion. In turn, we convert these temperature profiles to thermal stress profiles, assuming the edifice is largely undeformable. We show that these high linear thermal expansion coefficients of the hydrothermally altered

  3. Solubility of lead and copper in biochar-amended small arms range soils: influence of soil organic carbon and pH.

    Science.gov (United States)

    Uchimiya, Minori; Bannon, Desmond I

    2013-08-14

    Biochar is often considered a strong heavy metal stabilizing agent. However, biochar in some cases had no effects on, or increased the soluble concentrations of, heavy metals in soil. The objective of this study was to determine the factors causing some biochars to stabilize and others to dissolve heavy metals in soil. Seven small arms range soils with known total organic carbon (TOC), cation exchange capacity, pH, and total Pb and Cu contents were first screened for soluble Pb and Cu concentrations. Over 2 weeks successive equilibrations using weak acid (pH 4.5 sulfuric acid) and acetate buffer (0.1 M at pH 4.9), Alaska soil containing disproportionately high (31.6%) TOC had nearly 100% residual (insoluble) Pb and Cu. This soil was then compared with sandy soils from Maryland containing significantly lower (0.5-2.0%) TOC in the presence of 10 wt % (i) plant biochar activated to increase the surface-bound carboxyl and phosphate ligands (PS450A), (ii) manure biochar enriched with soluble P (BL700), and (iii) unactivated plant biochars produced at 350 °C (CH350) and 700 °C (CH500) and by flash carbonization (corn). In weak acid, the pH was set by soil and biochar, and the biochars increasingly stabilized Pb with repeated extractions. In pH 4.9 acetate buffer, PS450A and BL700 stabilized Pb, and only PS450A stabilized Cu. Surface ligands of PS450A likely complexed and stabilized Pb and Cu even under acidic pH in the presence of competing acetate ligand. Oppositely, unactivated plant biochars (CH350, CH500, and corn) mobilized Pb and Cu in sandy soils; the putative mechanism is the formation of soluble complexes with biochar-borne dissolved organic carbon. In summary, unactivated plant biochars can inadvertently increase dissolved Pb and Cu concentrations of sandy, low TOC soils when used to stabilize other contaminants.

  4. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (Chinese Edition)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-09-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  5. Signature proteins for the major clades of Cyanobacteria

    Directory of Open Access Journals (Sweden)

    Mathews Divya W

    2010-01-01

    Full Text Available Abstract Background The phylogeny and taxonomy of cyanobacteria is currently poorly understood due to paucity of reliable markers for identification and circumscription of its major clades. Results A combination of phylogenomic and protein signature based approaches was used to characterize the major clades of cyanobacteria. Phylogenetic trees were constructed for 44 cyanobacteria based on 44 conserved proteins. In parallel, Blastp searches were carried out on each ORF in the genomes of Synechococcus WH8102, Synechocystis PCC6803, Nostoc PCC7120, Synechococcus JA-3-3Ab, Prochlorococcus MIT9215 and Prochlor. marinus subsp. marinus CCMP1375 to identify proteins that are specific for various main clades of cyanobacteria. These studies have identified 39 proteins that are specific for all (or most cyanobacteria and large numbers of proteins for other cyanobacterial clades. The identified signature proteins include: (i 14 proteins for a deep branching clade (Clade A of Gloebacter violaceus and two diazotrophic Synechococcus strains (JA-3-3Ab and JA2-3-B'a; (ii 5 proteins that are present in all other cyanobacteria except those from Clade A; (iii 60 proteins that are specific for a clade (Clade C consisting of various marine unicellular cyanobacteria (viz. Synechococcus and Prochlorococcus; (iv 14 and 19 signature proteins that are specific for the Clade C Synechococcus and Prochlorococcus strains, respectively; (v 67 proteins that are specific for the Low B/A ecotype Prochlorococcus strains, containing lower ratio of chl b/a2 and adapted to growth at high light intensities; (vi 65 and 8 proteins that are specific for the Nostocales and Chroococcales orders, respectively; and (vii 22 and 9 proteins that are uniquely shared by various Nostocales and Oscillatoriales orders, or by these two orders and the Chroococcales, respectively. We also describe 3 conserved indels in flavoprotein, heme oxygenase and protochlorophyllide oxidoreductase proteins that

  6. Using Vegetation Maps to Provide Information on Soil Distribution

    Science.gov (United States)

    José Ibáñez, Juan; Pérez-Gómez, Rufino; Brevik, Eric C.; Cerdà, Artemi

    2016-04-01

    Many different types of maps (geology, hydrology, soil, vegetation, etc.) are created to inventory natural resources. Each of these resources is mapped using a unique set of criteria, including scales and taxonomies. Past research has indicated that comparing the results of different but related maps (e.g., soil and geology maps) may aid in identifying deficiencies in those maps. Therefore, this study was undertaken in the Almería Province (Andalusia, Spain) to (i) compare the underlying map structures of soil and vegetation maps and (ii) to investigate if a vegetation map can provide useful soil information that was not shown on a soil map. To accomplish this soil and vegetation maps were imported into ArcGIS 10.1 for spatial analysis. Results of the spatial analysis were exported to Microsoft Excel worksheets for statistical analyses to evaluate fits to linear and power law regression models. Vegetative units were grouped according to the driving forces that determined their presence or absence (P/A): (i) climatophilous (climate is the only determinant of P/A) (ii); lithologic-climate (climate and parent material determine PNV P/A); and (iii) edaphophylous (soil features determine PNV P/A). The rank abundance plots for both the soil and vegetation maps conformed to Willis or Hollow Curves, meaning the underlying structures of both maps were the same. Edaphophylous map units, which represent 58.5% of the vegetation units in the study area, did not show a good correlation with the soil map. Further investigation revealed that 87% of the edaphohygrophylous units (which demand more soil water than is supplied by other soil types in the surrounding landscape) were found in ramblas, ephemeral riverbeds that are not typically classified and mapped as soils in modern systems, even though they meet the definition of soil given by the most commonly used and most modern soil taxonomic systems. Furthermore, these edaphophylous map units tend to be islands of biodiversity

  7. Proteomic Analysis of Peripheral Blood Mononuclear Cells after a High-Fat, High-Carbohydrate Meal with Orange Juice.

    Science.gov (United States)

    Chaves, Daniela F S; Carvalho, Paulo C; Brasili, Elisa; Rogero, Marcelo M; Hassimotto, Neuza A; Diedrich, Jolene K; Moresco, James J; Yates, John R; Lajolo, Franco M

    2017-11-03

    Oxidative stress and inflammation play a role in the physiopathology of insulin resistance, diabetes and cardiovascular disease. A single high-fat, high-carbohydrate (HFHC) meal induces an increase in inflammatory and oxidative stress markers in peripheral blood mononuclear cells (PBMC). Previous studies have shown that orange juice is able to prevent this response by inhibiting toll like receptors (TLR) expression and endotoxemia. Our goal was to study the proteome response in PBMC after the consumption of a HFHC meal consumed with water, orange juice or an isocaloric beverage (water with glucose). Twelve healthy individuals completed the protocol in a crossover design, and blood samples were obtained before and 1, 3, and 5 h after consumption. Proteomic profile, glucose, insulin, lipid and cytokines levels were investigated. The glycemic and insulinemic response was higher when the meal was consumed with glucose, while there was no difference in the response between water and orange juice. Proteome analysis in PBMC was carried out using TMT ten-plex. A total of 3813 proteins, originating from 15 662 peptides were identified. Three proteins showed significantly altered expression in the three treatments: apolipoprotein A-II, ceruloplasmin and hemopexin. When the HFHC meal was consumed with water there was an increase in some inflammatory pathways such as the Fc-gamma receptor dependent phagocytosis and the complement cascade, but the immune system as a whole was not significantly altered. However, when the meal was consumed with glucose, the immune system was up regulated. Among the pathways induced after 3 h were those of the adaptive immune system and cytokine signaling. Five hours after the meal, pathways of the complement cascade and classical antibody mediated complement activation were up regulated. When the meal was consumed with orange juice there was an up regulation of proteins involved in signal transduction, DNA replication and cell cycle. The

  8. Manual for first responders to a radiological emergency. Emergency preparedness and response. Publication date: October 2006

    International Nuclear Information System (INIS)

    2006-10-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. As stated in IAEA Safety Standards Series No. GS-R-2 'Preparedness and Response for a Nuclear or Radiological Emergency', which establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, 'first responders shall take all practicable and appropriate actions to minimize the consequences of a nuclear or radiological emergency'. The IAEA General Conference, in resolution GC(49)/RES/9, continues to encourage Member States 'to adopt the relevant Agency standards, procedures and practical tools' and underlines 'the need for first responders to have appropriate training for dealing with ionizing radiation during nuclear and radiological emergencies'. This publication is intended to assist in meeting these requirements and to fulfil Article 5 of the Assistance Convention. Its aim is to provide practical guidance for those who will respond during the first few hours to a radiological emergency (referred to here as 'first responders') and for national officials who would support this early response. It provides guidance in the form of action guides, instructions, and supporting data that can be easily applied by a State to build a basic capability to respond to a radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This report, published as part of the IAEA Emergency Preparedness and Response Series, replaces and builds on IAEA-TECDOC-1162 in the area of early response and first responders' actions. It takes account of the

  9. Actions to Protect the Public in an Emergency due to Severe Conditions at a Light Water Reactor. Date Effective: May 2013 (Spanish Edition)

    International Nuclear Information System (INIS)

    2016-01-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the 'Assistance Convention'), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to a nuclear or radiological emergency. This publication is intended to help fulfil in part these functions assigned to the IAEA in the Assistance Convention. The aim of this publication is to provide those persons who are responsible for making and for acting on decisions in the event of an emergency at a light water reactor with an understanding of the actions that are necessary to protect the public. The publication provides a basis for developing the tools and criteria at the preparedness stage that would be needed in taking protective actions and other actions in response to such an emergency. The publication applies the safety principles stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and it will be of assistance to Member States in meeting the requirements established in IAEA Safety Standards Series No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. The application of these requirements is intended to minimize the consequences for people and the environment in any nuclear or radiological emergency. This guidance should be adapted to fit the State's organizational arrangements, language, terminology, concept of operation and capabilities. The IAEA General Conference, in resolution GC(55)/RES/9: 'Emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the Agency's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other

  10. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme (Spanish Edition); Consideraciones sobre preparación y respuesta para casos de emergencia destinadas a un Estado que inicie un programa nucleoeléctrico

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-07-15

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  11. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme (Russian Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  12. SU-F-T-155: Validation of a Commercial Monte Carlo Dose Calculation Algorithm for Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Saini, J; Wong, T [SCCA Proton Therapy Center, Seattle, WA (United States); St James, S; Stewart, R; Bloch, C [University of Washington, Seattle, WA (United States); Traneus, E [Raysearch Laboratories AB, Stockholm. (Sweden)

    2016-06-15

    Purpose: Compare proton pencil beam scanning dose measurements to GATE/GEANT4 (GMC) and RayStation™ Monte Carlo (RMC) simulations. Methods: Proton pencil beam models of the IBA gantry at the Seattle Proton Therapy Center were developed in the GMC code system and a research build of the RMC. For RMC, a preliminary beam model that does not account for upstream halo was used. Depth dose and lateral profiles are compared for the RMC, GMC and a RayStation™ pencil beam dose (RPB) model for three spread out Bragg peaks (SOBPs) in homogenous water phantom. SOBP comparisons were also made among the three models for a phantom with a (i) 2 cm bone and a (ii) 0.5 cm titanium insert. Results: Measurements and GMC estimates of R80 range agree to within 1 mm, and the mean point-to-point dose difference is within 1.2% for all integrated depth dose (IDD) profiles. The dose differences at the peak are 1 to 2%. All of the simulated spot sigmas are within 0.15 mm of the measured values. For the three SOBPs considered, the maximum R80 deviation from measurement for GMC was −0.35 mm, RMC 0.5 mm, and RPB −0.1 mm. The minimum gamma pass using the 3%/3mm criterion for all the profiles was 94%. The dose comparison for heterogeneous inserts in low dose gradient regions showed dose differences greater than 10% at the distal edge of interface between RPB and GMC. The RMC showed improvement and agreed with GMC to within 7%. Conclusion: The RPB dosimetry show clinically significant differences (> 10%) from GMC and RMC estimates. The RMC algorithm is superior to the RPB dosimetry in heterogeneous media. We suspect modelling of the beam’s halo may be responsible for a portion of the remaining discrepancy and that RayStation will reduce this discrepancy as they finalize the release. Erik Traneus is employed as a Research Scientist at RaySearch Laboratories. The research build of the RayStation TPS used in the study was made available to the SCCA free of charge. RaySearch did not provide

  13. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (Arabic Edition)

    International Nuclear Information System (INIS)

    2014-01-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  14. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme (Arabic Edition)

    International Nuclear Information System (INIS)

    2014-01-01

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  15. Manual for first responders to a radiological emergency. Emergency preparedness and response

    International Nuclear Information System (INIS)

    2008-01-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. As stated in IAEA Safety Standards Series No. GS-R-2 'Preparedness and Response for a Nuclear or Radiological Emergency', which establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, 'first responders shall take all practicable and appropriate actions to minimize the consequences of a nuclear or radiological emergency'. The IAEA General Conference, in resolution GC(49)/RES/9, continues to encourage Member States 'to adopt the relevant Agency standards, procedures and practical tools' and underlines 'the need for first responders to have appropriate training for dealing with ionizing radiation during nuclear and radiological emergencies'. This publication is intended to assist in meeting these requirements and to fulfil Article 5 of the Assistance Convention. Its aim is to provide practical guidance for those who will respond during the first few hours to a radiological emergency (referred to here as 'first responders') and for national officials who would support this early response. It provides guidance in the form of action guides, instructions, and supporting data that can be easily applied by a State to build a basic capability to respond to a radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This report, published as part of the IAEA Emergency Preparedness and Response Series, replaces and builds on IAEA-TECDOC-1162 in the area of early response and first responders' actions. It takes account of the

  16. [Orthogonal design method to optimize rehabilitation prescription of pulsed electric field at Jiaji (EX-B 2) points for spinal cord injury].

    Science.gov (United States)

    Zhang, Lifeng; Zhang, Hui; Wang, Lin; Liu, Yanyan; Sun, Xianyue; Li, Lingyan; Hou, Jing

    2015-01-01

    By using orthogonal design method to optimnize prescription of pulsed electric field at Jiaji (EX- B 2) points for spinal cord injury (SCI). Fifty six patients of SCI were selected, in which 36 cases were divided into orthogonal design trial and 20 cases were into clinical verification. With 36 patients who received orthogonal design trial, Frankel grading scale was used as observation index to screen optimal prescription of pulsed electric field. Pulse frequency (factor A) included low frequency (factor A(I), 10(2) Hz). moderate frequency (factor A(II), 10(4) Hz) and high frequency (factor A(III), 10(3) Hz); pulse amplitude (factor B) included 0-30 V (factor B ), 0-60 V (factor B(II)) and 0-90 V (factor B(III)); pulse width (factor C) included 0.1 ms (factor C(I)). 0.6 ms (factor C(II)) and 0.9 ms (factor C(III)); acupuncture time (factor D) included one month (DI), three months (D(II)) and five months (D(III)). Twenty patients were used for clinical efficacy observation and the effects of screened optimal pre scription of pulsed electric field at Jiaji (EX-B 2) points combined with regular rehabilitation training on spasm se- verity, score of sensory and motor functions, Barthel index and Frankel score were observed. (1) As results of orthogonal design trial, the optimal prescription was A(III) B(III), C(I), D(III), which were high frequency (10(3) Hz), 0-90 V of pulse amplitude, 0.4 ms of pulse width and 5 months of treatment time. (2) As results of 20 patient clinical verification, Ashworth score, tendon reflex and clonus were all significantly improved (Ppulsed electric field at Jiaji (EX-B 2) points for spinal cord injury is high frequency (10& Hz), 0-90 V of pulse amplitude, 0.4 ms of pulse width and 5 months of treatment time. The optimal prescription of pulsed electric field at Jiaji (EX-B 2) points combined with regular rehabilitation could obviously improve spasm severity, enhance senso- ry and motor functions, and ameliorate activity of daily life and

  17. Metabolic hormones, apolipoproteins, adipokines, and cytokines in the alveolar lining fluid of healthy adults: compartmentalization and physiological correlates.

    Directory of Open Access Journals (Sweden)

    Carlos O Mendivil

    Full Text Available Our current understanding of hormone regulation in lung parenchyma is quite limited. We aimed to quantify a diverse array of biologically relevant protein mediators in alveolar lining fluid (ALF, compared to serum concentrations, and explore factors associated with protein compartmentalization on either side of the air-blood barrier.Participants were 24 healthy adult non-smoker volunteers without respiratory symptoms or significant medical conditions, with normal lung exams and office spirometry. Cell-free bronchoalveolar lavage fluid and serum were analyzed for 24 proteins (including enteric and metabolic hormones, apolipoproteins, adipokines, and cytokines using a highly sensitive multiplex ELISA. Measurements were normalized to ALF concentrations. The ALF:serum concentration ratios were examined in relation to measures of protein size, hydrophobicity, charge, and to participant clinical and spirometric values.ALF measurements from 24 individuals detected 19 proteins, including adiponectin, adipsin, apoA-I, apoA-II, apoB, apoC-II, apoC-III, apoE, C-reactive protein, ghrelin, glucose-dependent insulinotropic peptide (GIP, glucagon-like peptide-1 (GLP-1, glucagon, insulin, leptin, monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, resistin, and visfatin. C-peptide and serpin E1 were not detected in ALF for any individual, and IL-6, IL-10, and TNF-alpha were not detected in either ALF or serum for any individual. In general, ALF levels were similar or lower in concentration for most proteins compared to serum. However, ghrelin, resistin, insulin, visfatin and GLP-1 had ALF concentrations significantly higher compared to serum. Importantly, elevated ALF:serum ratios of ghrelin, visfatin and resistin correlated with protein net charge and isoelectric point, but not with molecular weight or hydrophobicity.Biologically relevant enteric and metabolic hormones, apolipoproteins, adipokines, and cytokines can be detected in the ALF of

  18. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (Russian Edition)

    International Nuclear Information System (INIS)

    2014-01-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  19. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (French Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  20. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response

    International Nuclear Information System (INIS)

    2012-05-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  1. Science-based design of stable quantum dots for energy-efficient lighting

    Energy Technology Data Exchange (ETDEWEB)

    Martin, James E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rohwer, Lauren E. S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); van Swol, Frank B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Zhou, Xiaowang [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lu, Ping [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    II-VI quantum dots, such as CdSe and CdTe, are attractive as downconversion materials for solid-state lighting, because of their narrow linewidth, tunable emission. However, for these materials to have acceptable quantum yields (QYs) requires that they be coated with a II-VI shell material whose valence band offset serves to confine the hole to the core. Confinement prevents the hole from accessing surface traps that lead to nonradiative decay of the exciton. Examples of such hole-confined core/shell QDs include CdTe/CdSe and CdSe/CdS. Unfortunately, the shell can also cause problems due to lattice mismatch, which ranges from 4-6% for systems of interest. This lattice mismatch can create significant interface energies at the heterojunction and places the core under radial compression and the shell under tangential tension. At elevated temperatures (~240°C) interfacial diffusion can relax these stresses, as can surface reconstruction, which can expose the core, creating hole traps. But such high temperatures favor the hexagonal Wurtzite structure, which has lower QY than the cubic zinc blende structure, which can be synthesized at lower temperatures, ~140°C. In the absence of alloying the core/shell structure can become metastable, or even unstable, if the shell is too thick. This can cause result in an irregular shell or even island growth. But if the shell is too thin thermallyactivated transport of the hole to surface traps can occur. In our LDRD we have developed a fundamental atomistic modeling capability, based on Stillinger-Weber and Bond-Order potentials we developed for the entire II-VI class. These pseudo-potentials have enabled us to conduct large-scale atomistic simulations that have led to the computation of phase diagrams of II-VI QDs. These phase diagrams demonstrate that at elevated temperatures the zinc blende phase of CdTe with CdSe grown on it epitaxially becomes thermodynamically unstable due to alloying. This is accompanied by a loss of hole

  2. Population pharmacokinetics of recombinant coagulation factor VIII-SingleChain in patients with severe hemophilia A.

    Science.gov (United States)

    Zhang, Y; Roberts, J; Tortorici, M; Veldman, A; St Ledger, K; Feussner, A; Sidhu, J

    2017-06-01

    Essentials rVIII-SingleChain is a unique recombinant factor VIII (FVIII) molecule. A population pharmacokinetic model was based on FVIII activity of severe hemophilia A patients. The model was used to simulate factor VIII activity-time profiles for various dosing scenarios. The model supports prolonged dosing of rVIII-SingleChain with intervals of up to twice per week. Background Single-chain recombinant coagulation factor VIII (rVIII-SingleChain) is a unique recombinant coagulation factor VIII molecule. Objectives To: (i) characterize the population pharmacokinetics (PK) of rVIII-SingleChain in patients with severe hemophilia A; (ii) identify correlates of variability in rVIII-SingleChain PK; and (iii) simulate various dosing scenarios of rVIII-SingleChain. Patients/Methods A population PK model was developed, based on FVIII activity levels of 130 patients with severe hemophilia A (n = 91 for ≥ 12-65 years; n = 39 for  85% and > 93% of patients were predicted to maintain FVIII activity level above 1 IU dL -1 , at all times with three-times-weekly dosing (given on days 0, 2, and 4.5) at the lowest (20 IU kg -1 ) and highest (50 IU kg -1 ) doses, respectively. For twice weekly dosing (days 0 and 3.5) of 50 IU kg -1 rVIII-SingleChain, 62-80% of patients across all ages were predicted to maintain a FVIII activity level above 1 IU dL -1 at day 7. Conclusions The population PK model adequately characterized rVIII-SingleChain PK, and the model can be utilized to simulate FVIII activity-time profiles for various dosing scenarios. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

  3. Actions to Protect the Public in an Emergency due to Severe Conditions at a Light Water Reactor. Date Effective: May 2013

    International Nuclear Information System (INIS)

    2013-01-01

    Under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the 'Assistance Convention'), one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to a nuclear or radiological emergency. This publication is intended to help fulfil in part these functions assigned to the IAEA in the Assistance Convention. The aim of this publication is to provide those persons who are responsible for making and for acting on decisions in the event of an emergency at a light water reactor with an understanding of the actions that are necessary to protect the public. The publication provides a basis for developing the tools and criteria at the preparedness stage that would be needed in taking protective actions and other actions in response to such an emergency. The publication applies the safety principles stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and it will be of assistance to Member States in meeting the requirements established in IAEA Safety Standards Series No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. The application of these requirements is intended to minimize the consequences for people and the environment in any nuclear or radiological emergency. This guidance should be adapted to fit the State's organizational arrangements, language, terminology, concept of operation and capabilities. The IAEA General Conference, in resolution GC(55)/RES/9: 'Emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the Agency's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other

  4. High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration.

    Directory of Open Access Journals (Sweden)

    Laura Pertl

    Full Text Available High-density lipoproteins (HDL have long been implicated in the pathogenesis of age-related macular degeneration (AMD. However, conflicting results have been reported with regard to the associations of AMD with HDL-cholesterol levels. The present study is the first to assess HDL composition and metrics of HDL function in patients with exudative AMD and control patients.Blood samples were collected from 29 patients with exudative AMD and 26 age-matched control patients. Major HDL associated apolipoproteins were determined in apoB-depleted serum by immunoturbidimetry or ELISA, HDL-associated lipids were quantified enzymatically. To get an integrated measure of HDL quantity and quality, we assessed several metrics of HDL function, including cholesterol efflux capacity, anti-oxidative and anti-inflammatory activities using apoB-depleted serum from study participants.In our study, we observed that the HDL associated acute phase protein serum amyloid A (SAA was significantly increased in AMD patients (p<0.01, whereas all other assessed apolipoproteins including ApoA-I, apoA-II, apoC-II, apoC-III and apoE as well as major HDL associated lipids were not altered. HDL efflux capacity, anti-oxidative capacity and arylesterase activity were not different in AMD patients when compared with the control group. The ability of apoB-depleted serum to inhibit monocyte NF-κB expression was significantly improved in AMD patients (mean difference (MD -5.6, p<0.01. Moreover, lipoprotein-associated phospholipase A2 activity, a marker of vascular inflammation, was decreased in AMD subjects (MD -24.1, p<0.01.The investigated metrics of HDL composition and HDL function were not associated with exudative AMD in this study, despite an increased content of HDL associated SAA in AMD patients. Unexpectedly, anti-inflammatory activity of apoB-depleted serum was even increased in our study. Our data suggest that the investigated parameters of serum HDL function showed no

  5. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme. Publication Date: August 2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-09-15

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  6. The National Socialist State in the View of Norbert Frei O estado nacional-socialista na ótica de Norbert Frei

    Directory of Open Access Journals (Sweden)

    Marco Pais Neves dos Santos

    2012-04-01

    Full Text Available This article has as context World War II, the largest and bloodiest conflict in human history, and is the conception of the National Socialist State produced by Norbert Frei, one of the most influential historians of our time, in his work: The State of Hitler: The national Socialist power from 1933 to 1945. It has as object how Norbert Frei conceives German history between the years of 1933-1945, and his critical eye on the National Socialist State, analysing not only from the standpoint of ideological crime and Social Darwinism, but also through the political and social history, including questioning the involvement and acceptance by society of Hitler's German government, revealing that despite Norbert Frei was born in Germany , he has never been hostage to the past, and always sought to open the debate, countering the difficulty of many Germans to remember Nazism, for whom "German guilt" of a pact with the regime, especially in the Holocaust, led them to hide for a few decades their recent past, what includes the intellectual circuits.Este artigo tem como perspetiva enquadrante a II Guerra Mundial, o maior e mais sangrento conflito da história da humanidade, e trata a conceção do Estado Nacional-Socialista produzida por Norbert Frei, um dos mais influentes historiadores da atualidade, na sua obra: O Estado de Hitler: o poder nacional-socialista de 1933 a 1945. Tem como objeto a forma como Norbert Frei concebe a história alemã, entre os anos de 1933-1945, e o seu olhar crítico sobre o Estado Nacional-Socialista, analisando-o não só do ponto de vista do crime ideológico, do darwinismo social, mas também através da história política e social, inclusive, questionando a participação e aceitação pela sociedade alemã da governação de Hitler, revelando que, apesar de ser um historiador natural da Alemanha, nunca esteve refém do passado e sempre procurou abrir o debate, contrariando a dificuldade de muitos alemães em recordarem o

  7. Communication with the Public in a Nuclear or Radiological Emergency. Emergency Preparedness and Response (Spanish Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The aim of this publication is to provide practical guidance for public information officers on the preparation for and response to a nuclear or radiological emergency, and to fulfil in part functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), as well as meeting requirements stated in IAEA Safety Standards Series No. SF-1, Fundamental Safety Principles, and in IAEA Safety Standards No. GS-R-2, Preparedness and Response for a Nuclear or Radiological Emergency. Under Article 5(a)(ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and results of research relating to response to nuclear or radiological emergencies. IAEA Safety Standards Series No. GS-R-2 establishes the requirements for an adequate level of preparedness for and response to a nuclear or radiological emergency in any State, and specifies that 'All practicable steps shall be taken to provide the public with useful, timely, truthful, consistent and appropriate information throughout a nuclear or radiological emergency' in the response phase. It also requires 'responding to incorrect information and rumours; and responding to requests for information from the public and from the news and information media'. This publication provides guidance in the form of action guides and information sheets that can be easily applied by a State to build a basic capability to respond to a nuclear or radiological emergency. This guidance should be adapted to fit the user State's organizational arrangements, language, terminology, concept of operation and capabilities. This publication is published as part of the IAEA's Emergency Preparedness and Response series and complements the Manual for First Responders to a Radiological Emergency in the parts related to the tasks of public information officers. It takes

  8. Development of Zinc Tin Nitride for Application as an Earth Abundant Photovoltaic Absorber

    Science.gov (United States)

    Fioretti, Angela N.

    In recent years, many new potential absorber materials based on earth-abundant and non-toxic elements have been predicted. These materials, often made in thin film form and known to absorb light 10-1000 times more e ciently than crystalline silicon, could lower module cost and enable broader solar deployment. One such material is zinc tin nitride (ZnSnN 2), a II-IV-nitride analog of the III-nitride materials, which was identified as a suitable solar absorber due to its direct bandgap, large absorption coefficient, and disorder-driven bandgap tunability. Despite these desirable properties, initial attempts at synthesis resulted in degenerate n-type carrier density. Computational work on the point defect formation energies for this material revealed three donor defects were likely the cause; specifically SnZn antisites, VN sites, and ON substitutions. Given this framework, a defect-driven hypothesis was proposed as a starting point for the present work: if each donor defect could be addressed by tuning deposition parameters, n-type degeneracy may be defeated. By using combinatorial co- sputtering to grow compositionally-graded thin film samples, n-type carrier density was reduced by two orders of magnitude compared to state-of-the-art. This reduction in carrier density was observed for zinc-rich samples, which supported the defect-driven hypothesis initially proposed. These results and their implications are the topic of Chapter 2. Further carrier density control in zinc-rich ZTN was achieved via hydrogen incorporation and post-growth annealing. This strategy was hypothesized to operate by passivating acceptor defects to avoid self-compensation, which were then activated by hydrogen drive- out upon annealing. Carrier density was reduced another order of magnitude using this technique, which is presented in Chapter 3. After defeating n-type degeneracy, a deeper understanding of the electronic structure was pursued. Photoluminescence (PL) was used to study electronic

  9. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme. Publication Date: August 2012

    International Nuclear Information System (INIS)

    2012-01-01

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  10. Considerations in Emergency Preparedness and Response for a State Embarking on a Nuclear Power Programme (Spanish Edition)

    International Nuclear Information System (INIS)

    2014-01-01

    The aim of this publication is to provide a practical tool for emergency planning for States embarking on a nuclear power programme and to fulfil, in part, functions assigned to the IAEA in the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency ('Assistance Convention'). Under Article 5.a (ii) of the Assistance Convention, one function of the IAEA is to collect and disseminate to State Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. As established in the publication Preparedness and Response for a Nuclear or Radiological Emergency (IAEA Safety Standards Series No. GS-R-2), the practical goal of emergency response is 'to ensure that arrangements are in place for a timely, managed, controlled, coordinated and effective response at the scene, and at the local, regional, national and international level, to any nuclear or radiological emergency'. In 2011 the IAEA General Conference, in resolution GC(55)/RES/9, encouraged States 'embarking on new nuclear power programmes to take timely and proactive steps, based upon gradual and systematic application of IAEA safety standards, to establish and sustain a strong safety culture'. It also 'emphasizes the importance for all Member States to implement emergency preparedness and response mechanisms and develop mitigation measures at a national level, consistent with the IAEA's Safety Standards, for improving emergency preparedness and response, facilitating communication in an emergency and contributing to harmonization of national criteria for protective and other actions'. This publication, issued in the IAEA Emergency Preparedness and Response Series, is intended to assist on steps to be taken by States embarking on a nuclear power programme to establish effective national capabilities and arrangements of preparedness for and response to a nuclear or radiological emergency (hereinafter referred to as

  11. [GeSIDA/National AIDS Plan: Consensus document on antiretroviral therapy in adults infected by the human immunodeficiency virus (Updated January 2014)].

    Science.gov (United States)

    2014-01-01

    This consensus document is an update of combined antiretroviral therapy (cART) guidelines for HIV-1 infected adult patients. To formulate these recommendations a panel composed of members of the Grupo de Estudio de Sida and the Plan Nacional sobre el Sida reviewed the efficacy and safety advances in clinical trials, cohort and pharmacokinetic studies published in medical journals (PubMed and Embase) or presented in medical scientific meetings. Recommendations strength and the evidence in which they are supported are based on modified criteria of the Infectious Diseases Society of America. In this update, antiretroviral therapy (ART) is recommended for all patients infected by type 1 human immunodeficiency virus (HIV-1). The strength and grade of the recommendation varies with the clinical circumstances: CDC stage B or C disease (A-I), asymptomatic patients (depending on the CD4+ T-lymphocyte count: 500 cells/μL, B-III), comorbid conditions (HIV nephropathy, chronic hepatitis caused by HBV or HCV, age >55years, high cardiovascular risk, neurocognitive disorders, and cancer, A-II), and prevention of transmission of HIV (mother-to-child or heterosexual, A-I; men who have sex with men, A-III). The objective of ART is to achieve an undetectable plasma viral load. Initial ART should always comprise a combination of 3 drugs, including 2 nucleoside reverse transcriptase inhibitors and a third drug from a different family (non-nucleoside reverse transcriptase inhibitor, protease inhibitor, or integrase inhibitor). Some of the possible initial regimens have been considered alternatives. This update presents the causes and criteria for switching ART in patients with undetectable plasma viral load and in cases of virological failure where rescue ART should comprise 2 or 3 drugs that are fully active against the virus. An update is also provided for the specific criteria for ART in special situations (acute infection, HIV-2 infection, and pregnancy) and with comorbid

  12. Sposób prowadzenia badań archeologiczno-architektonicznych, a możliwości wykorzystania ich wyników w procesie projektowym na przykładzie byłego Szpitala im. Babińskiego we Wrocławiu.

    Directory of Open Access Journals (Sweden)

    Justyna Kleszcz

    2018-04-01

    Full Text Available Niniejszy artykuł stanowi omówienie zagadnienia trybu i sposobu prowadzenia badań archeologiczno-architektonicznych ze szczególnym uwzględnieniem możliwości prawnych oraz analizę skutków (pozytywnych i negatywnych wyboru poszczególnych form na sposób, w jaki prowadzone są prace projektowe oraz możliwości ekspozycji odsłoniętych reliktów. Zagadnienia te zostaną omówione głównie na przykładzie prac prowadzonych od 2015 roku na obszarze byłego szpitala im. Babińskiego przy placu Jana Pawła II we Wrocławiu przez zespół badawczy pod kierunkiem dr inż. arch. Piotra Kmiecika oraz dr Roberta Szweda, przy współudziale dr Czesława Lasoty. Teren byłego Szpitala był zdecydowanie jednym z najciekawszych pod względem archeologiczno – architektonicznym we Wrocławiu, jednocześnie jednak również jednym z najbardziej skomplikowanych. Na stopień skomplikowania miało wpływ nie tyle nagromadzenie warstw kulturowych i spodziewanych odkryć, a samo położenie oraz nawarstwienie ciągłych przekształceń obszaru, skutkujące gęstą zabudową, a także nagromadzeniem czynnych magistrali sieciowych o znaczeniu tranzytowym, ukształtowaniem powiązań komunikacyjnych w obrębie rozległego obszaru i ukształtowaniem zieleni objętej ochroną prawną. Jednoczesne wystąpienie tylu czynników spowodowało niemożliwość oszacowania zakresu i wielkości prowadzonych prac przed ich rozpoczęciem, wymusiło elastyczność oraz konieczność zaaranżowania badań z uwzględnieniem udziału ekip budowlanych w ich trakcie. Poziom komplikacji wymuszał także pewne modyfikacje w trybie prowadzonych prac, co ukazuje konieczność weryfikacji podejścia do restrykcyjnego podziału, oraz ukazuje szereg możliwości, jakie daje ściślejsza współpraca na linii architekt-archeolog-urząd konserwatora zabytków-budowa.

  13. Risky future for Mediterranean forests unless they undergo extreme carbon fertilization.

    Science.gov (United States)

    Gea-Izquierdo, Guillermo; Nicault, Antoine; Battipaglia, Giovanna; Dorado-Liñán, Isabel; Gutiérrez, Emilia; Ribas, Montserrat; Guiot, Joel

    2017-07-01

    Forest performance is challenged by climate change but higher atmospheric [CO 2 ] (c a ) could help trees mitigate the negative effect of enhanced water stress. Forest projections using data assimilation with mechanistic models are a valuable tool to assess forest performance. Firstly, we used dendrochronological data from 12 Mediterranean tree species (six conifers and six broadleaves) to calibrate a process-based vegetation model at 77 sites. Secondly, we conducted simulations of gross primary production (GPP) and radial growth using an ensemble of climate projections for the period 2010-2100 for the high-emission RCP8.5 and low-emission RCP2.6 scenarios. GPP and growth projections were simulated using climatic data from the two RCPs combined with (i) expected c a ; (ii) constant c a  = 390 ppm, to test a purely climate-driven performance excluding compensation from carbon fertilization. The model accurately mimicked the growth trends since the 1950s when, despite increasing c a , enhanced evaporative demands precluded a global net positive effect on growth. Modeled annual growth and GPP showed similar long-term trends. Under RCP2.6 (i.e., temperatures below +2 °C with respect to preindustrial values), the forests showed resistance to future climate (as expressed by non-negative trends in growth and GPP) except for some coniferous sites. Using exponentially growing c a and climate as from RCP8.5, carbon fertilization overrode the negative effect of the highly constraining climatic conditions under that scenario. This effect was particularly evident above 500 ppm (which is already over +2 °C), which seems unrealistic and likely reflects model miss-performance at high c a above the calibration range. Thus, forest projections under RCP8.5 preventing carbon fertilization displayed very negative forest performance at the regional scale. This suggests that most of western Mediterranean forests would successfully acclimate to the coldest climate change scenario

  14. Compartmental Modeling and Dosimetry of in Vivo Metabolic Studies of Leucine and Three Secretory Proteins in Humans Using Radioactive Tracers

    Science.gov (United States)

    Venkatakrishnan, Vaidehi

    1995-01-01

    Physical and mathematical models provide a systematic means of looking at biological systems. Radioactive tracer kinetic studies open a unique window to study complex tracee systems such as protein metabolism in humans. This research deals with compartmental modeling of tracer kinetic data on leucine and apolipoprotein metabolism obtained using an endogenous tritiated leucine tracer administered as a bolus, and application of compartmental modeling techniques for dosimetric evaluation of metabolic studies of radioiodinated apolipoproteins. Dr. Waldo R. Fisher, Department of Medicine, was the coordinating research supervisor and the work was carried out in his laboratory. A compartmental model for leucine kinetics in humans has been developed that emphasizes its recycling pathways which were examined over two weeks. This model builds on a previously published model of Cobelli et al, that analyzed leucine kinetic data up to only eight hours. The proposed model includes different routes for re-entry of leucine from protein breakdown into plasma accounting for proteins which turn over at different rates. This new model successfully incorporates published models of three secretory proteins: albumin, apoA-I, and VLDL apoB, in toto thus increasing its validity and utility. The published model of apoA-I, based on an exogenous radioiodinated tracer, was examined with data obtained using an endogenous leucine tracer using compartmental techniques. The analysis concludes that the major portion of apoA-I enters plasma by a fast pathway but the major fraction of apoA-I in plasma resides with a second slow pathway; further the study is suggestive of a precursor-product relationship between the two plasma apoA-I pools. The possible relevance of the latter suggestion to the aberrant kinetics of apoA-I in Tangier disease is discussed. The analysis of apoA-II data resulted in similar conclusions. A methodology for evaluating the dosimetry of radioiodinated apolipoproteins by

  15. 链脲佐菌素诱导的小鼠糖尿病视网膜病模型及促血管新生分子的表达%Streptozotocin induced diabetic retinopathy in C57 mice and the expression of some pro-angiogenic molecules

    Institute of Scientific and Technical Information of China (English)

    余增洋; 陆宾; 龚陈媛; 季莉莉

    2016-01-01

    AIM: To estabIish the mice modeI of streptozotocin (STZ)-induced proIiferative diabetic retinopathy (PDR), and observe the aItered expression of some pro -angiogenic moIecuIes such as vascuIar endotheIiaI growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2), and matrix metaIIoproteinase ( MMP2 and MMP9 ) during the deveIopment of PDR. METHODS:C57BL/6J mice were intraperitoneaI injected with STZ (55 mg/kg) for 5 consecutive days, and bIood gIucose concentrations were measured after 7d of the injection. The diabetic mice were further housed for 3, 4, 5mo respectiveIy after the deveIopment of diabetes. HistoIogicaI evaIuation of retinas was performed. The retinaI vesseIs were detected by immunofIuorescence staining with the cIuster of differentiation 31 ( CD31 ) . The mRNA expression of VEGF, VEGFR1, VEGFR2, MMP2 and MMP9 in mice retinas was detected by ReaI-time PCR anaIysis. RESULTS: RetinaI histoIogicaI observation and CD31 staining both demonstrate that there are more vesseIs in diabetic mice than in normaI controI mice at 5mo after the deveIopment of diabetes. As compared with normaI controI, the mRNA expression of VEGF, VEGFR1, VEGFR2, MMP2 and MMP9 are aII increased in diabetic mice at 5mo after the deveIopment of diabetes. CONCLUSION: This study demonstrates that PDR is occurred at 5mo after the deveIopment of diabetes in STZ-induced diabetic mice. In addition, the mRNA expression of VEGF, VEGFR1, VEGFR2, MMP2 and MMP9 are aII increased after the deveIopment of PDR.%目的::建立链脲佐菌素( streptozotocin, STZ)诱导的小鼠增殖性糖尿病视网膜病( proliferative diabetic retinopathy, PDR)动物模型,并观察在增殖性糖尿病视网膜病发生、发展过程中血管内皮生长因子( vascular endothelial growth factor, VEGF)及其受体(VEGFR1, VEGFR2),金属基质蛋白酶(matrix metalloproteinase, MMP)2, MMP9表达的变化。方法:C57 BL/6 J小鼠连续5 d腹腔注射STZ (55 mg/kg )。末次注射后7d检测血糖浓度。

  16. Autotransfusão de coleta pré-operatória em cirurgia cardíaca Pré-operative blood sampling for autotransfusion during cardiac surgery

    Directory of Open Access Journals (Sweden)

    Fábio B Jatene

    1988-04-01

    Full Text Available A autotransfusão (AT que utiliza a reposição de sangue autógeno constitui uma alternativa para a redução das complicações da transfusão de sangue homólogo, já que, em cirurgias eletivas, existe a possibilidade da coleta de sangue no período pré-operatório. Foi realizado um estudo comparativo prospectivo para tentar estabelecer os parâmetros ideais da AT pré-operatória, referentes ao volume, intervalo de tempo prévio à cirurgia e benefício aos pacientes, entre outros. Foram considerados, para o estudo, 96 pacientes consecutivos a serem submetidos a revascularização miocárdica. As cirurgias foram eletivas e os pacientes não apresentavam hipoproteinemia, anemia, infecções, operações cardíacas prévias, outras cirurgias recentes, ou, então, mais de 70 anos de idade. Foram divididos em 4 grupos; Grupo I: sem AT pré (controle, 41 pacientes; Grupo II: Coleta de 500 a 600 ml, sendo Grupo II-A até 7 dias antes da operação (35 pacientes e Grupo II B de 8 a 15 dias antes (14 pacientes e Grupo III com coleta realizada acima de 30 dias da operação, com reinfusão e nova coleta a cada 15 dias (6 pacientes. A idade média e o hematócrito foram comparáveis, nos 4 grupos. Em alguns pacientes, utilizou-se, também, a AT no pós-operatório. Os resultados revelaram que 63% do Grupo I, 26% no Grupo II-A, 43% no Grupo II-B e 67% no Grupo III receberam sangue homólogo. A média de sangue autógeno recebido foi de 534 ml/paciente no Grupo II-A, 539 ml/paciente no Grupo II-B e 908 ml/paciente no Grupo III. O hematócrito, no pós-operatório, foi comparável nos 4 grupos, por ocasião da alta. Não houve óbitos. Os autores concluem que um menor número de pacientes do Grupo II-A recebeu sangue homólogo (ES p = 0,008 e não houve diferença estatística (ES entre os grupos II-A, II-B e III, com relação ao volume de sangue homólogo recebido. Além disto, não houve aumento de complicações, particularmente sangramento, em

  17. Diagnósticos de enfermagem de idosos que utilizam múltiplos medicamentos Diagnósticos de enfermería de ancianos polimedicados Nursing diagnoses of elderly patients using multiple drugs

    Directory of Open Access Journals (Sweden)

    Maria José Sanches Marin

    2010-03-01

    Full Text Available Considerando que os idosos que utilizam múltiplos medicamentos são propensos à maior vulnerabilidade nas condições de saúde, propomo-nos, neste estudo: identificar os diagnósticos de enfermagem, segundo a taxonomia II de NANDA, de um grupo de idosos que utilizam cinco ou mais medicamentos. Foram selecionados 67 idosos, a partir da Avaliação Geriátrica Ampla (AGA entre 301 residentes na área de abrangência de um Programa de Saúde da Família (PSF. Os 67 idosos apresentaram 16 categorias diagnósticas, em média 5,2 diagnósticos/idoso, sendo os mais frequentes a dor crônica, presente em 59,7% dos idosos; 58,2% têm a mobilidade física prejudicada; 47,7%, nutrição desequilibrada (mais que as necessidades corporais, e 47,7% têm um controle ineficaz do regime terapêutico. Tais diagnósticos revelam a necessidade de medidas envolvendo mudanças no estilo de vida, além do acompanhamento sistemático dessas pessoas.Considerando que los ancianos que utilizan múltiples medicamentos son propensos a una mayor vulnerabilidad en sus condiciones de salud, nos proponemos en este estudio identificar los diagnósticos de enfermería según la taxonomía II de NANDA, de un grupo de ancianos que utilizan cinco o más medicamentos. Fueron seleccionados 67 ancianos, a partir de la Avaliação Geriátrica Ampla (AGA, entre 301 residentes en el área comprendida por un Programa de Salud Familiar (PSF. Los 67 ancianos presentaron 16 categorías diagnósticas, con una media de 5,2 diagnósticos/anciano, siendo los más frecuentes el dolor crónico (afectando a un 59,7%, la movilidad física reducida (58,2%, nutrición desequilibrada -por encima de las necesidades corporales- (47,7% y control ineficaz del régimen terapéutico (47,7%. Tales diagnósticos determinan la necesidad de medidas que implican cambios sustanciales en el estilo de vida, además del seguimiento médico sistemático de dichas personas.Considering that elderly people using

  18. Znaczenie snu i sposoby poprawy jego jakości u sportowców = Impact of sleep and methods to improve its quality in the context of sporting activities

    Directory of Open Access Journals (Sweden)

    Aleksandra Frydrych-Szymonik

    2016-05-01

    2Section of Sports Medicine and Human Nutrition, Faculty of Physical Education and Sport, The University of Physical Education in Krakow   Aleksandra Frydrych-Szymonik, afrydrychszymonik@gmail.com, tel. 601 146 509 AWF w Krakowie, Al. Jana Pawła II 78, 31-571 Kraków     Słowa kluczowe: deficyt snu, drzemka, odnowa biologiczna sportowców, używki Key words: sleep disorders, nap, athletic recovery, drugs   Streszczenie Cel Pracy Celem pracy było określenie znaczenia snu i wskazanie sposobów poprawy jego jakości u sportowców na podstawie przeglądu piśmiennictwa naukowego. Materiał i Metody Do analizy wybrano zagraniczne artykuły opublikowane w latach 2005 do 2015, korzystając z bazy danych: Medline EBSCO, Medline Ovid, PubMed oraz internetową wyszukiwarkę artykułów naukowych – Google Scholar. W przeglądzie uwzględniono prace oryginalne, zawierające w temacie (subjects pojęcia: „sleep” i „athletes”. Z analizy wykluczono prace dotyczące medycznych zaburzeń snu oraz te, które nie mają związku ze sportem. Wyniki Zaburzenia snu stają się coraz częstszą przyczyną obniżania sprawności psychofizycznej zawodników, a biorą się one głównie z niewielkiej wiedzy na temat higieny snu. Zbyt mała liczba godzin snu powoduje szereg negatywnych zmian w organizmie, co w konsekwencji ma związek z obniżeniem zdolności wysiłkowej sportowców. Wnioski Należy dbać o prawidłową jakość i ilość snu oraz wprowadzać odpowiednio zaplanowane drzemki regeneracyjne w odnowie biologicznej zawodników. W działaniach optymalizujących sen sportowców należy również brać pod uwagę fakt, iż dieta, nawyki żywieniowe oraz używki mają znaczący wpływ na jakość i ilość snu człowieka.   Abstract The aim of the study was to define the impact of sleep and identify methods to improve its quality in athletes , drawing on a review of the scientific literature. Methods Foreign literature published from 2005 to 2015 was reviewed

  19. Gonadotropin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction.

    Science.gov (United States)

    McCabe, M J; Tarulli, G A; Laven-Law, G; Matthiesson, K L; Meachem, S J; McLachlan, R I; Dinger, M E; Stanton, P G

    2016-04-01

    Are Sertoli cell tight junctions (TJs) disrupted in men undergoing hormonal contraception? Localization of the key Sertoli cell TJ protein, claudin-11, was markedly disrupted by 8 weeks of gonadotropin suppression, the degree of which was related to the extent of adluminal germ cell suppression. Sertoli cell TJs are vital components of the blood-testis barrier (BTB) that sequester developing adluminal meiotic germ cells and spermatids from the vascular compartment. Claudin-11 knockout mice are infertile; additionally claudin-11 is spatially disrupted in chronically gonadotropin-suppressed rats coincident with a loss of BTB function, and claudin-11 is disorganized in various human testicular disorders. These data support the Sertoli cell TJ as a potential site of hormonal contraceptive action. BTB proteins were assessed by immunohistochemistry (n = 16 samples) and mRNA (n = 18 samples) expression levels in available archived testis tissue from a previous study of 22 men who had undergone 8 weeks of gonadotropin suppression and for whom meiotic and post-meiotic germ cell numbers were available. The gonadotropin suppression regimens were (i) testosterone enanthate (TE) plus the GnRH antagonist, acyline (A); (ii) TE + the progestin, levonorgestrel, (LNG); (iii) TE + LNG + A or (iv) TE + LNG + the 5α-reductase inhibitor, dutasteride (D). A control group consisted of seven additional men, with three archived samples available for this study. Immunohistochemical localization of claudin-11 (TJ) and other junctional type markers [ZO-1 (cytoplasmic plaque), β-catenin (adherens junction), connexin-43 (gap junction), vinculin (ectoplasmic specialization) and β-actin (cytoskeleton)] and quantitative PCR was conducted using matched frozen testis tissue. Claudin-11 formed a continuous staining pattern at the BTB in control men. Regardless of gonadotropin suppression treatment, claudin-11 localization was markedly disrupted and was broadly associated with the extent of meiotic

  20. Guerra e desenvolvimento biológico: o caso da biotecnologia e da genômica na segunda metade do século XX Warfare and biological development: the case of biotechnology and genomics during the second half of the 20th Century

    Directory of Open Access Journals (Sweden)

    Maria Eneida de Almeida

    2006-09-01

    Full Text Available Desde a década de 1980, a Biotecnologia vem assumindo um papel cada vez mais importante dentro do planejamento estratégico das Grandes Potências, como elemento central para um novo tipo de arma ofensiva de destruição em massa e como paradigma para o planejamento de defesa e proteção de suas populações nacionais. Para defender esta tese, nosso estudo se orientou exatamente na história do deslocamento da Biologia para o centro do planejamento de defesa americano. Nosso objetivo foi investigar a existência de uma estreita relação entre o Desenvolvimento Biotecnológico, da ciência Genômica em particular, e a questão da guerra. Nossa hipótese é que a Biotecnologia se afirmou no campo da guerra, quando foram atingidos um ponto de condensação de fatos políticos e uma confluência de possibilidades biotécnicas que estimularam acentuadamente o interesse político-militar. A metodologia para a investigação desta conexão deu-se por dois caminhos: uma análise teórica, onde encontramos as origens e o mecanismo da Big Science desde a II Guerra Mundial, quando a Física assumiu o eixo central da ciência de ponta na era atômica, e desde a década de 1980, quando a Biologia passou a ocupar um lugar central; e uma análise historiográfica, acompanhando duas trajetórias convergentes que, para a nossa tese, formam o nervo central do Desenvolvimento Biotecnológico, da Guerra Biológica e do Projeto Genoma Humano.Since the 1980's, biotechnology has played an increasingly predominant role in the strategic planning of the super-powers, as the central element of a new type of mass destruction weapon as well as a model for defense planning and protection of their national populations. This study aims to demonstrate the path taken by Biology towards the core of American defense planning and also to investigate the close relationship between biotechnological development, in particular that of Genome Science and war. The specific hypothesis

  1. Niveles de plomo en la población de alto riesgo y su entorno en San Ignacio, Fresnillo, Zacatecas, México Lead levels in high-risk populations and the surrounding environment in San Ignacio, Fresnillo, Zacatecas, México

    Directory of Open Access Journals (Sweden)

    Eduardo Manzanares-Acuña

    2006-06-01

    Full Text Available OBJETIVO: Determinar la concentración de plomo en la sangre de niños y mujeres, en periodo de lactancia o embarazadas, de la comunidad de San Ignacio, Fresnillo, en Zacatecas, así como en matrices de suelo, plantas, ceniza y barro vidriado, para determinar la exposición que genera una empresa recicladora de metales. MATERIAL Y MÉTODOS: El estudio se realizó de diciembre de 2004 al mes de abril de 2005. El Pb en sangre se midió por voltamperometría de redisolución anódica, mientras que se utilizó energía dispersa de fluorescencia por rayos X para las otras matrices. RESULTADOS: Con base en los criterios de la Norma Oficial Mexicana (NOM se encontró que 90% de los menores está en la categoría I, 5% se encuentra en la categoría II y el otro 5% se ubica en la categoría III. El suelo de los terrenos aledaños a la recicladora tiene en promedio 4 940 µg/g, en un intervalo de 73 a 84 238 µg/g. Las mayores concentraciones se localizan en los puntos más cercanos a la empresa. El suelo de San Ignacio tiene en promedio 109 µg/g. Se encontraron valores altos en el barro vidriado y la concentración del Pb en las plantas es superior a los 300 µg/g. CONCLUSIONES: A pesar de que la mayoría de los niños analizados presenta niveles de plomo en sangre que la Norma Mexicana señala como aceptables, varios estudios indican que existen efectos nocivos aun a concentraciones bajas. Los terrenos aledaños a la empresa están contaminados, y en esa medida los alimentos que ahí se producen, al ser consumidos, son una fuente de contaminación, que se agudiza con el uso de barro vidriado.OBJECTIVE:To determine the lead concentration in the blood of children and nursing or pregnant women from San Ignacio, Fresnillo, in Zacatecas, Mexico as well as in soil, plants, ash and lead-glazed pottery, in order to determine exposure due to a metal-recycling facility. MATERIAL AND METHODS: The study was carried out from December 2004 to April 2005. Lead in

  2. Implantação do diagnóstico de enfermagem em unidade de terapia intensiva: uma análise periódica Aplicación de diagnóstico de enfermería en la unidad de cuidados intensivos: una revisión periódica Implementation of nursing diagnosis in the intensive care unit: a periodic review

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    Angelita Paganin

    2010-06-01

    Full Text Available O conhecimento acerca da prevalência dos diagnósticos de enfermagem (DE contribui para a previsão dos cuidados necessários e para a orientação de programas de educação permanente. Estudo com delineamento transversal, que teve por objetivo identificar os principais DE de uma unidade de terapia intensiva (UTI, comparando-se as diferentes categorias entre os pacientes clínicos e cirúrgicos. A análise dos dados foi realizada de acordo com a taxonomia II da North American Nursing Diagnoses Association (NANDA. Nos 150 prontuários avaliados foram encontrados 195 diagnósticos, com uma média de 1,3 DE por paciente, majoritariamente do domínio segurança e proteção (39,5%. Os DE mais freqüentes foram: integridade tissular prejudicada (22%, troca de gases prejudicada (22%, perfusão tissular ineficaz cerebral (8,7%, integridade da pele prejudicada (7,7%, débito cardíaco diminuído (6,7% e perfusão tissular ineficaz cardiopulmonar (6,1%. Os DE mais prevalentes denotam as necessidades fisiológicas como as mais comuns na amostra estudada.El conocimiento acerca de la prevalencia de los diagnósticos de enfermería (DE ayuda a brindar la atención necesaria y la orientación de los programas de educación continua. Estudio que identifico los principales DE prescrito en la unidad de cuidados intensivos (UCI y compararlos entre pacientes médicos y quirúrgicos. Análisis de los datos se realizó de acuerdo a la taxonomía II de la North American Nursing Diagnoses Association (NANDA. En las 150 cartas evaluados fueron encontrados 195 diagnósticos, con un promedio de 1,3 por paciente, principalmente en el campo y la seguridad (39,5%. Los DE más comunes fueron: deterioro de la integridad tisular (22%, deterioro del intercambio gaseoso (22%, ineficacia de la perfusión tisular cerebral (8,7%, alteración de la integridad cutánea (7,7%, disminución del gasto cardíaco (6 , 7% y la perfusión tisular inefectiva cardiopulmonar (6,1%. Lo m

  3. [Infants' attachment security in a vulnerable French sample].

    Science.gov (United States)

    Tereno, S; Guedeney, N; Dugravier, R; Greacen, T; Saïas, T; Tubach, F; Ulgen, S; Matos, I; Guédeney, A

    2017-04-01

    and Infant Protection System) is particularly generous and (b) the effect of this usual system might have been increased by the project intensive assessment protocol (6 visits during 28 months). Secondly, it is possible that the full effect of the intervention had not yet been detected because, when a child's attachment was assessed, only two thirds of the intervention visits had been performed (29 of 44 visits). A "sleeper effect" is still possible: we hope that a more clear result will be seen when children are assessed again, at 48 months, in our follow-up study (CAPEDP-A II). By clarifying the mechanisms involved in the development of a secure attachment, our study aims to contribute and refine the development of early preventive intervention strategies in high perinatal and psychosocial vulnerability contexts. Copyright © 2016 L’Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.

  4. Diagnósticos de enfermagem de idosas carentes de um programa de saúde da família (PSF Diagnósticos de enfermería de ancianas carentes de un programa de salud de la familia (PSF Nursing diagnoses of pauper elderly women of a family health program (FHP

    Directory of Open Access Journals (Sweden)

    Maria José Sanches Marin

    2008-06-01

    Full Text Available Considerando que as mulheres idosas e pobres são propensas à maior vulnerabilidade nas condições de saúde, no presente estudo propôs-se a identificar os diagnósticos de enfermagem, segundo a taxonomia II de NANDA, sobre um grupo de idosas consideradas muito pobres. Foram selecionadas 69 idosas, a partir da aplicação do instrumento de Classificação Econômica Brasil (CCEB em 301 idosos residentes na área de abrangência de um PSF. O estado de saúde das idosas foi avaliado utilizando-se a Avaliação Geriátrica Ampla (AGA, que envolve os aspectos funcionais, emocionais, sociais e ambientais. Foram identificadas 23 categorias diagnósticas nas idosas do estudo e uma média de 7,4 diagnósticos/ idosa. Entre os diagnósticos mais freqüentes destacam-se " Mobilidade física prejudicada","Dor crônica","Manutenção do lar prejudicada". Os diagnósticos revelaram-se impor tantes na caracterização das complexas necessidades apresentadas pelas idosas e no grande avanço no direcionamento da assistência.Considerando que las mujeres ancianas pobres son propensas a mayor vulnerabilidad en las condiciones de salud, proponemos en este estudio identificar los diagnósticos de enfermería según la taxonomía II de NANDA de un grupo de ancianas consideradas muy pobres. Fueran seleccionadas 69 ancianas, a partir de la aplicación del instrumento de Clasificación Económica Brasil (CCEB en 301 ancianos residentes en el área de alcance de un PSF. El estado de salud de las ancianas fue evaluado utilizándose de la Evaluación Geriátrica Amplia (AGA que involucra los aspectos funcionales, emocionales, sociales y ambientales. Fueron encontradas 23 categorías diagnósticas en las ancianas del estudio y un promedio de 7,4 diagnósticos/anciana. Entre los diagnósticos más frecuentes se destacan: " Mobilidad física perjudicada"; "Dolor crónica"; "Manutención del hogar perjudicada". Los diagnósticos se han revelado importantes en la

  5. Perfil de diagnósticos de enfermagem em pessoas com diabetes segundo modelo conceitual de Orem Perfil de diagnósticos de enfermería en personas con diabetes según el modelo conceptual de Orem Nursing diagnoses in people with diabetes mellitus according to Orem's theory of self-care

    Directory of Open Access Journals (Sweden)

    Carla Regina de Souza Teixeira

    2009-01-01

    Full Text Available OBJETIVO: Identificar os diagnósticos de enfermagem em pessoas com diabetes mellitus, segundo o modelo conceitual de Orem. MÉTODOS: Participaram 31 pessoas com diabetes atendidas em um Centro Universitário de Pesquisa e Extensão, do interior paulista, em 2006. Os dados foram obtidos por meio de exame físico e entrevista dirigida de casos múltiplos. Os diagnósticos de enfermagem foram identificados segundo a Taxonomia II da NANDA, mediante o processo de raciocínio diagnóstico de Risner. RESULTADOS: Dos 37 diagnósticos de enfermagem, três apresentaram freqüência superior a 50%: controle ineficaz do regime terapêutico (67%, conhecimento deficiente (51% e integridade da pele prejudicada (51%. Dezoito diagnósticos de enfermagem estavam relacionados aos requisitos para o autocuidado universal, preconizado por Orem CONCLUSÃO: Os diagnósticos de enfermagem mostraram-se indicadores diferenciados para guiar as ações educativas do enfermeiro com enfoque no desenvolvimento das habilidades de autocuidado para pessoas com diabetes.OBJETIVO: Identificar los diagnósticos de enfermería en personas con diabetes mellitus, según el modelo conceptual de Orem. MÉTODOS: Participaron en el estudio 31 personas con diabetes atendidas en un Centro Universitario de Investigación y Extensión, del interior paulista, en el 2006. Los datos fueron obtenidos por medio de examen físico y entrevista dirigida de casos múltiples. Los diagnósticos de enfermería fueron identificados según la Taxonomía II de la NANDA, mediante el proceso de raciocinio diagnóstico de Risner. RESULTADOS: De los 37 diagnósticos de enfermería, tres presentaron frecuencia superior al 50%: control ineficaz del régimen terapéutico (67%, conocimiento deficiente (51% e integridad de la piel perjudicada (51%. Dieciocho diagnósticos de enfermería estaban relacionados a los requisitos para el autocuidado universal, preconizado por Orem. CONCLUSIÓN: Los diagnósticos de

  6. Assistência de enfermagem ao portador de Hanseníase: abordagem transcultural Asistencia de enfermería al portador de Lepra: abordaje transcultural Nursing assistance to a Leprosy-infected patient: transcultural approach

    Directory of Open Access Journals (Sweden)

    Fernando José Guedes da Silva Júnior

    2008-11-01

    Full Text Available Trata-se de um estudo de caso, desenvolvido em um Centro de Saúde em Teresina - PI, que abordou a problemática da assistência de enfermagem prestada a uma paciente com Hanseníase Multibacilar, enfocando o cuidado de Enfermagem Transcultural, Diagnósticos e Intervenções de Enfermagem segundo a Taxonomia II da NANDA. Realizou-se a entrevista semi-estruturada e observação participante, que possibilitaram a coleta dos dados, os quais foram tratados baseados nos padrões normativos, valores e prática diárias, modos de cuidado popular e cuidados requeridos no sistema profissional. Neste estudo, constatou-se que o planejamento da assistência de enfermagem visou, principalmente, contribuir para a adesão ao tratamento da doença, diminuindo os riscos potenciais e utilizando a preservação, negociação e re-padronização do sistema profissional. Observou-se também a adesão ao tratamento e a realização de autocuidado voltado para a hanseníase de forma culturalmente satisfatória.Es un estudio de caso, desarrollado en un centro de salud en Teresina-PI, que abordó la problemática de la asistencia de enfermería dada a una paciente con lepra multibacilar, enfocando el cuidado de Enfermería Transcultural, Diagnósticos, e Intervenciones de Enfermería segundo la Taxonomía II de NANDA. Se realizó una entrevista semi-estructurada y observación participante, que posibilitaron la colecta de los datos, los cuales fueron tratados basados em los padrones normativos, valores y prácticas diárias, modos de cuidado popular y cuidados requeridos en el sistema profesional. En este estudio, se constató que el planeamiento de la asistencia de enfermería objetivó, principalmente, contribuir para la adhesión al tratamiento de la enfermidad, disminuyendo los riscos potenciales y utilizando la preservación, negociación y repradonización del sistema profesional. Se observó también la adhesión al tratamiento y la realización del auto cuidado

  7. Da liberalização cega dos anos 90 à construção estratégica do desenvolvimento From the blind liberalization of the 90's to the strategic building of development

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    Glauco Arbix

    2002-05-01

    Full Text Available Este texto foi apresentado na aula inaugural do curso de Ciências Sociais da USP, realizada no dia 6 de março de 2002. A economia global vem sendo sacudida por alterações profundas que vêm alterando os métodos, a estrutura produtiva de bens e serviços, a política e as instituições em todos os cantos do planeta. Essas mudanças estão sendo mais sentidas nos países que apresentam em sua história uma presença marcante do Estado sobre as economias e a vida social. Na América Latina, essas mudanças orientaram a implantação de um novo modelo de política econômica, como forma de superar a inflação crescente, os déficts comerciais, o fardo da dívida externa, a ineficiência e a falta de competitividade internacional que, supostamente, haviam se configurado como fruto das tradicionais políticas desenvolvimentistas. No entanto, esse novo modelo opera com uma interpretação tortuosa da história dos países em desenvolvimento, jogando no esquecimento ou tornando incompreensível que países como Brasil, Argentina e México, ao lado de outros asiáticos, cresceram após a II Guerra Mundial mais rapidamente que Estados Unidos, Inglaterra, Alemanha, França e Canadá. A elaboração de estratégias de desenvolvimento, incluindo a qualidade da industrialização desejada, da tecnologia, das instituições e da política, continua sendo o principal desafio a ser vencido pelos países atrasados.This paper was presented as the inaugural class for the Social Sciences Course at USP, on the 6th of March of 2002. Global economy has been undergoing a number of sweeping changes that have altered the methods, the organization of the production of goods and services, politics and institutions all over the world. These changes have been more marked in countries where State policies exert strict control over the economy and social life. In Latin America, these changes guided the implementation of a new economic policy model, as a means to overcome

  8. Sumário de atualização da II Diretriz Brasileira de Insuficiência Cardíaca Aguda 2009/2011

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    Marcelo Westerlund Montera

    2012-05-01

    Full Text Available Nos últimos dois anos, observamos diversas modificações na abordagem diagnóstica e terapêutica dos pacientes com Insuficiência Cardíaca aguda (IC aguda, o que nos motivou quanto à necessidade da realização de um sumário de atualização da II Diretriz Brasileira de Insuficiência Cardíaca Aguda de 2009. Na avaliação diagnóstica, o fluxograma diagnóstico foi simplificado e foi fortalecido o papel da avaliação clínica e ecocardiograma. Na avaliação clínico-hemodinâmica admissional, o ecocardiograma hemodinâmico ganhou destaque no auxilio da definição dessa condição no paciente com IC aguda na sala de emergência. Na avaliação prognóstica, os biomarcadores tiveram seu papel mais bem estabelecido, e a síndrome cardiorrenal teve seus critérios e valor prognóstico mais bem definidos. Os fluxogramas de abordagem terapêutica foram revistos, tornando-se mais simples e objetivos. Dentre os avanços na terapêutica medicamentosa destacam-se a segurança e a importância da manutenção ou introdução dos betabloqueadores na terapêutica admissional. A anticoagulação, de acordo com as novas evidências, ganha um espectro maior de indicações. O edema agudo de pulmão tem bem estabelecido os seus modelos hemodinâmicos de apresentação com suas distintas formas de abordagens terapêuticas, com novos níveis de indicação e evidência. No tratamento cirúrgico da IC aguda, a revascularização miocárdica, a abordagem das lesões mecânicas e o transplante cardíaco foram revistos e atualizados. Este sumário de atualização fortalece a II Diretriz Brasileira de Insuficiência Cardíaca Aguda por mantê-la atualizada e rejuvenescida. Todos os clínicos cardiologistas que lidam com pacientes com IC aguda encontrarão na diretriz e em seu sumário de atualização importantes instrumentos no auxílio da prática clínica para o melhor diagnóstico e tratamento de seus pacientes.

  9. Costa Rica’s Marine Protected Areas: status and perspectives

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    Juan José Alvarado

    2012-03-01

    ínea de costa, de las cuales 20 son AMP clasificadas como Parque Nacionales (90.6%, Refugios de Vida Silvestre (6.6%, humedales (1.5%, Reservas Biológicas (1% y una Reserva Natural Absoluta (0.3%. De acuerdo a los criterios de la UICN, 93.7% corresponden a la categoría II, 5% a la IV y 1.3% a la I. El área marina protegida es de 5 296.5km², correspondiendo al 17.5% de las aguas territoriales y al 0.9% de la Zona Económica Exclusiva. La distancia promedio entre AMP es de 22.4km en el Pacífico y 32.9km en el Caribe. El tamaño medio está cercano a los 54km². Las amenazas principales son la falta de coordinación entre agencias gubernamentales, recursos económicos limitados, control y patrullaje restringido, pobre manejo de cuencas y una acelerada alteración costera.

  10. Hemaglutinina de folhas de mandioca (Manihot esculenta Crantz: purificação parcial e toxicidade Hemaglutinin of cassava leaves (Manihot esculenta Crantz: partial purification and toxicity

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    Chrystian Araujo Pereira

    2008-06-01

    Full Text Available Um dos componentes da multimistura para suplementação alimentar de populações carentes é a farinha de folhas de mandioca (FFM que possui elevado conteúdo em proteínas, vitaminas e minerais. Todavia, as folhas de mandioca também apresentam substâncias antinutritivas e/ou tóxicas, como cianeto, polifenóis, nitrato, ácido oxálico, hemaglutinina, saponinas e inibidores de tripsina. Objetivou-se neste trabalho extrair as proteínas da FFM, purificando-as em coluna cromatográfica e determinar sua atividade hemaglutinante e toxicidade. Foram testadas várias estratégias de extração e precipitação das proteínas, sendo que o maior teor protéico e atividade hemaglutinante foi obtido na extração com água destilada na proporção 1:20 (p/v seguida da precipitação com sulfato de amônio a 80% de saturação. As proteínas precipitadas foram purificadas em coluna Q-Sepharose. Das quatro frações obtidas na purificação (I, II, III e IV, a I e a II apresentaram maiores atividades hemaglutinantes. As mesmas frações foram injetadas via intraperitoneal em camundongos com doses de 2mg (fração I, 3mg (fração II, 54mg (fração III e 52mg (fração IV para cada animal com 20g de peso médio, não sendo observadas mortes ou quaisquer efeitos adversos após 120h.One of the components of the multimixture to the feed supplementation of low-income populations is cassava leaf flour (FFM, with high content of proteins, vitamins and minerals. However, cassava leaves also present substance regarded as antinutritive and/or toxic, such as cyanide, polyphenols, nitrate, oxalic acid, hemagglutinin, saponins and trypsin inhibitors. The aim of this work was to extract proteins from FFM, purifying them in chromatographic column and determine their hemagglutinating activity and toxicity. A number of strategies of extraction and precipitation of proteins were tested; the highest protein content and hemagglutinating activity were obtained in the

  11. Bystander effects in radiotherapy of non-small cell lung cancer

    International Nuclear Information System (INIS)

    McKenzie, D.R.

    2011-01-01

    Full text: School of Physics, The University of Sydney, Australia Objectives The bystander effect causes a response in unirradiated cells that are in communication with cells that receive a radiation dose. In recent work we have shown that there are 3 types bystander effect and that the expression of these effects follows a Ii course. The aim of this work is to identify the conditions for the three types of bystander effects in radiotherapy of non-small cell II cancer. A human non small cell lung cancer cell line (NCI-H460) was irradiated with a 6 MV photon beam produced from a Varian I i near accelerator to doses of 2, 4, 6 and 8 Gy. These cells v termed donor cells. At selected time intervals after exposure (5,15 and 60 min), the medium was transferred to receiver cells of the cell line in separate flasks. The clonogenic survival fraction of the receiver cells was determined following 5 days of incubation comparing cells receiving transfer of medium from exposed cells to cell receiving transfer from sham exposed cells. The experimental design controlled for the density of cells in the donor flask, the e of irradiation on the medium alone and on the donor cell metabolites. The results show a strong time course for the bystander signal expression, which is dependent on the density of cells in the donor receiver flasks. Sub lethal doses of radiation resulted in a proliferative response at short time intervals after exposure [15 min] but a toxic response when medium transfer was carried out after 60 min. A higher cell density in the donor flasks produces an increased response in the receiver flasks for the same volume of medium transferred. The latter response corresponds to Bystander Effect type 1 in which a reduced survival is observed in cells receiving medium from cells that receive a high but not lethal dose. The proliferative response, corresponding to Bystander Effect type 3 is more general and is not strongly dependent on dose. Following a lethal dose of

  12. Identificação do risco de quedas em idosos após acidente vascular encefálico Identicación del riesgo de caídas en ancianos después de accidente cerebrovascular Identification of the risk of falls in elderly after stroke

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    Alice Gabrielle de Sousa Costa

    2010-12-01

    Full Text Available O objetivo desse estudo foi identificar a ocorrência do diagnóstico de enfermagem Risco de quedas em indivíduos idosos acometidos por acidente vascular encefálico. Estudo do tipo exploratório, realizado em unidades de reabilitação, no período de novembro de 2007 a março de 2008, por meio de entrevista e exame físico. Utilizou-se a Taxonomia II da Nursing American North Diagnosis Association quanto à nomeação diagnóstica. A população foi composta por 73 idosos com idade média de 69,5 anos, predominância do sexo feminino, baixo nível de escolaridade e renda financeira. Encontrou-se média de 1,6 episódio de acidente vascular encefálico em 2,4 anos. O diagnóstico esteve presente na totalidade dos participantes, e os fatores de risco mais percebidos foram: Força diminuída nas extremidades inferiores, Mobilidade física prejudicada, Dificuldades na marcha e Equilíbrio prejudicado. Assim, a avaliação diagnóstica contínua e individualizada faz-se imprescindível para nortear ações preventivas aos problemas de saúde dos idosos.El estudio tuvo como objetivo identificar la ocurrencia del diagnóstico de enfermería Riesgo de caídas en ancianos con enfermedad cerebrovascular. Estudio exploratorio, desarrollado en unidades de rehabilitación, de noviembre de 2007 a marzo de 2008, por medio de entrevista y examen físico. Se utilizó la Taxonomía II de la Nursing American North Diagnosis Association para la designación del diagnóstico. La populación fue compuesta por 73 ancianos con 69,5 años en media, predominancia de mujeres, bajo nivel educacional y renta financiera. Se encontró media de 1,6 episodios de enfermedad cerebrovascular en 2,4 años. El diagnóstico fue presente en la totalidad de los participantes y los factores de riesgo más percibidos fueron: Disminución de la fuerza en las extremidades inferiores, Movilidad física perjudicada, Dificultades en la marcha y Equilibrio perjudicado. La evaluación diagn

  13. Resolving the velocity and strain fields in the Upper Rhine Graben Area from a Combination of Levelling, GNSS and InSAR

    Science.gov (United States)

    Westerhaus, Malte; Fuhrmann, Thomas; Mayer, Michael; Zippelt, Karl; Heck, Bernhard

    2016-04-01

    velocity field taking into account effects due to different reference frames. As the measurement points of the three techniques do not coincide, appropriate interpolation methods, such as Kriging, are applied in order to calculate the estimates on a common grid. Mean formal errors of the combined solutions are 0.2 mm/a and 0.4 mm/a for the vertical and horizontal components, respectively, while the spatial resolution is considerably increased compared to earlier studies. The results reflect important aspects of the contemporary kinematic behaviour of the URG: (i) NW-SE shortening of the central URG segment of up to 0.5 mm/a, (ii) subsidence of the graben interior coinciding with known quaternary depocentres, (iii) left-lateral shearing resulting in ongoing shear strain accumulation within the graben. In addition, the solution depicts numerous local deformation phenomena due to man-made activities that have been studied in detail. Our results recover the recent intraplate deformation of the URG area with unprecedented accuracy and spatial resolution and provide an improved insight into the underlying processes.

  14. Diagnósticos de Enfermagem identificados em gestantes durante o pré-natal Diagnósticos de Enfermería identificados en embarazos durante el prenatal Nursing Diagnoses identified in pregnant patients under prenatal care

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    Sandra Valéria Martins Pereira

    2005-12-01

    Full Text Available Esta pesquisa descritiva objetivou analisar o perfil de Diagnósticos de Enfermagem identificados em gestantes de baixo-risco. Participaram onze gestantes atendidas no pré-natal de uma maternidade segura no estado de Goiás. Os dados foram classificados segundo a taxonomia II da North American Nursing Diagnosis Association (NANDA e analisados à luz de referenciais da obstetrícia. Foram identificados 25 diferentes Diagnósticos de Enfermagem. Todas as gestantes apresentaram: Conhecimento deficiente (diferentes graus e assuntos, Padrão de sono perturbado, Intolerância à atividade percebida, Déficit do autocuidado (banho e higiene, Incontinência urinária por pressão e alguns diagnósticos de risco. Identificar Diagnóstico de Enfermagem da NANDA permite a determinação do grau de risco gestacional, detecção precoce de complicações e individualização da assistência de enfermagem.Este estudio descriptivo pretende analizar el perfil de Diagnósticos de Enfermería identificados en embarazos de bajo riesgo. Participaron once embarazadas atendidas en el prenatal de una maternidad confiable en el estado de Goiás. Los datos fueron clasificados según la taxonomía II de la North American Nursing Diagnosis Association (NANDA/Asociación Norteamericana de Diagnósticos de Enfermería y analizados bajo los referenciales de la obstetricia. Fueron identificados 25 diferentes Diagnósticos de Enfermería. Todas las embarazadas presentaron: Conocimiento insuficiente (diferentes grados y asuntos, Patrón de sueño alterado, Intolerancia a la actividad percibida, falta de auto-higiene (baño e higiene personal, Incontinencia urinaria por presión y algunos diagnósticos de riesgo. Identificar Diagnóstico de Enfermería de NANDA permite la determinación del grado de riego, detección precoz de complicaciones e individualización de la asistencia de enfermería.This descriptive research aimed to analyze the Nursing Diagnoses identified in low

  15. Evaluación de la recuperación de la clase funcional y modificación de los parámetros ecocadiográficos y la morbimortalidad en pacientes con cardiopatía valvular mitral intervenidos en el Hospital San Ignacio

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    Giovanny Ríos D

    2013-04-01

    Full Text Available Objetivo: describir los resultados funcionales y la morbimortalidad en pacientes con cardiopatía valvular mitral que fueron llevados a cirugía en el Hospital San Ignacio entre los anos 2005 a 2009. Métodos: se revisó el registro quirúrgico del servicio de Cirugía Cardiovascular del Hospital San Ignacio durante los anos descritos. A partir de éste se obtuvo información de los documentos de identidad de cada uno de los pacientes para acceder a la información de las historias clínicas. Se revisaron las historias clínicas de pacientes atendidos en el Hospital, durante el periodo comprendido entre enero de 2005 a octubre de 2009, con diagnóstico de cardiopatía valvular mitral al ingreso. A partir de esta documentación y de los datos del seguimiento se obtuvo la estadística. Resultados y conclusiones: la enfermedad valvular cardíaca es una patología frecuente, compleja, que demanda normas claras de evaluación y seguimiento, además de criterios adecuados para llevar al paciente a cirugía en el momento más oportuno, seleccionar el tipo de prótesis que mejor se ajuste a la edad y sopesar el riesgo del manejo anticoagulante tal como lo predicen los estudios internacionales. La edad promedio de los pacientes intervenidos en el Hospital San Ignacio está alrededor de los 60,4 anos. Las mujeres son la población más afectada por valvulopatía mitral. El mayor porcentaje de los pacientes atendidos proviene de Bogotá. La patología mitral más intervenida es la insuficiencia mitral en 74% de los casos. El manejo más frecuente es el cambio valvular mitral, con 58% de los casos, y de éstos con válvula mecánica en 55,5% de los casos. Las prótesis más utilizadas son las mecánicas y de éstas prevalecen las prótesis ONX en 59,8% sobre las mecánicas. Posterior a la cirugía es notable el cambio en la clase funcional I a II en la mayoría de los pacientes. La mejoría de la clínica no se ve representada en un cambio ecocardiogr

  16. Incorporação de lodo de lavanderia industrial na fabricação de tijolos cerâmicos Incorporation of industrial laundry mud in the production of ceramic bricks

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    L. C. S. Herek

    2009-09-01

    Full Text Available O lodo gerado em ETEs de lavanderias industriais é um material não inerte de Classe IIA, devido �� sua solubilidade em água. Este resíduo tem recebido atenção especial devido à grande quantidade produzida e, consequentemente, ao custo demandado para destino em aterros industriais. O objetivo deste trabalho é avaliar a qualidade dos tijolos cerâmicos de vedação, fabricados com lodo de lavanderia industrial incorporado em massa cerâmica vermelha, pelo processo de extrusão, em escala de laboratório (73 x 35 x 55 mm, com os seguintes percentuais de lodo de lavanderia: 0 (modelo, 5, 10, 15 e 20% em peso. Após a queima, em indústria cerâmica, a qualidade dos tijolos foi analisada por meio de ensaios de resistência à compressão, absorção de água, lixiviação e solubilização. Nos resultados obtidos observou-se que a resistência à compressão é inversamente proporcional à quantidade de lodo adicionada, enquanto a absorção de água é diretamente proporcional à mesma quantidade de lodo adicionada na fabricação dos tijolos. No ensaio de lixiviação nenhum dos metais pesados analisados foi lixiviado; para o ensaio de solubilização nenhum dos metais analisados foi detectado, comprovando que o produto é inerte. De acordo com os resultados obtidos, é possível a fabricação de tijolos de vedação com até 20% de resíduo de lavanderias industriais incorporados em argila.The sludge from wastewater treatment in industrial laundries is a II-A class non-inert material, due to its solubility in water. This waste has been paid special attention, due to the large quantities that are produced and therefore the high cost of the final destination in landfills. This way, the objective of this work was to evaluate the quality of sealing ceramic bricks manufactured with sludge from industrial laundry incorporated in red ceramic mass, by the extrusion process, in laboratory scale (73 x 35 x 55 mm, with the following weight

  17. Tendência secular de crescimento em escolares de Paulínia, São Paulo-Brasil (1979/80 - 1993/94 Secular trends of growth of schoolchildren from Paulínia, São Paulo - Brazil (1979/80 - 1993/94

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    Denise Barbieri Marmo

    2004-12-01

    Full Text Available OBJETIVO: Avaliar a tendência secular de altura, peso e da relação peso/altura em escolares de Paulínia, São Paulo, Brasil, entre 1979/80 e 1993/94. MÉTODOS: Medidas antropométricas de peso (P e altura (A e da relação P/A de 1.903 crianças de 6,5 a 12,5 anos (51,5% M e 48,5% F de escolas públicas de Paulínia foram comparadas com dados de estudo anterior realizado na mesma cidade, com intervalo de 15 anos. Calculou-se o incremento por década e alisou-se os dados pela técnica de médias e medianas móveis (3H3H3. RESULTADOS: As médias de altura e peso foram sempre superiores às do estudo anterior, com incrementos positivos. Os incrementos para a altura variaram de 1,13 a 5 cm no sexo masculino e 1,2 a 4,33 cm nas meninas, já para o peso a variação foi de 0,53 a 4,13 kg nos meninos e 0,87 a 3,0 kg nas meninas. Para a relação P/A, as médias dos dois estudos foram muito semelhantes em ambos os sexos. CONCLUSÕES: A tendência secular positiva da estatura e do peso neste período deve-se principalmente ao desenvolvimento econômico, de saneamento básico, de habitação, de educação e na área de saúde ocorrido na cidade de Paulínia. A tendência secular positiva encontrada foi semelhante à observada em países desenvolvidos após a II Guerra Mundial e de outros trabalhos brasileiros.BACKGROUND: The purpose of this study was to evaluate the secular trends in height, weight and weight/height of schoolchildren from the city of Paulínia, São Paulo, Brazil between 1979/80 and 1993/94. METHODS: Anthropometric measurements (height, weight and weight/height of 1,903 children (6.5-12.5y; 51.5% M: 48.5% F, from Paulínia public schools were compared with data from a previous study carried out in the same city 15 years earlier. Decade increments were calculated and data was smoothed by the technique of means and medians (3H3H3. RESULTS: Height and weight mean values were always greater than those of the previous study, with positive

  18. Arteterapia na assistência de enfermagem em oncologia: produções, expressões e sentidos entre pacientes e estudantes de graduação Terapia con arte en la ayuda de enfermería en oncología: producciones, expresiones y sentidos entre pacientes y estudiantes de Graduación Art therapy in oncology's nursing care: productions, expressions and meanings among patients and graduation students

    Directory of Open Access Journals (Sweden)

    Izabel Cristina Falcão Juvenal Barbosa

    2007-06-01

    Full Text Available O objetivo deste artigo é relatar a experiência vivida por um grupo de alunas do Curso de Graduação em Enfermagem da Universidade Federal do Ceará, na disciplina Administração do Processo de Trabalho em Enfermagem II, na administração do ócio dos pacientes em um hospital de Fortaleza-CE. A experiência didática foi uma representação plástica a partir do Quadro de Referência Cognitivo-Comportamental realizado em abril de 2002, e teve como sujeitos sete pacientes e seis alunas de enfermagem. A criatividade artística dos pacientes fluiu em conseqüência do diálogo do artista com sua produção. A análise das produções artísticas foi complementada pelas observações das alunas. As obras produzidas foram interpretadas com a ajuda do teste de cores de Lüscher o que permitiu inferir o comportamento e os sentimentos exteriorizados nas cores variadas selecionadas pelos pacientes.El objetivo de este artículo es relatar la experiencia vivida por un grupo de alumnas del Curso de Graduación en Enfermería de la Universidad Federal del Ceará (Brasil, en la disciplina Administración del Proceso de Trabajo en Enfermería II, en la administración de la ociosidad de los pacientes en un hospital de Fortaleza - Ceára, Brasil. La experiencia didáctica fue una representación plástica desde el Cuadro de Referencia Cognoscitivo y del Comportamiento realizado en abril de 2002, y tenía como sujetos siete pacientes y seis alumnas de enfermería. La creatividad artística de los pacientes fluyó en consecuencia del diálogo del artista con su producción. El análisis de las producciones artísticas fue complementado por las observaciones de las alumnas. Las obras producidas habían sido interpretadas con la ayuda de la prueba de colores de Lüscher que permitió inferir en el comportamiento y en las sensaciones exteriorizadas en los colores variados seleccionados por los pacientesThe objective of this article is to report the experience

  19. MOCVD Growth and Characterization of n-type Zinc Oxide Thin Films

    Science.gov (United States)

    Ben-Yaacov, Tammy

    In the past decade, there has been widespread effort in the development of zinc oxide as a II-V1 semiconductor material. ZnO has potential advantages in optoelectronip device applications due to its unique electrical and optical properties. What stands out among these properties is its wide direct bandgap of 3.37 eV and its high electrical conductivity and transparency in the visible and near-UV regions of the spectrum. ZnO can be grown heteroepitaxially on GaN under near lattice-matched conditions and homoepitaxially as well, as high-quality bulk ZnO substrates are commercially available. This dissertation focuses on the development of the growth of high-quality, single crystal n-type ZnO films, control of n-type conductivity, as well as its application as a transparent contact material in GaN-based devices. The first part of this dissertation is an extensive heteroepitaxial and homoepitaxial growth study presenting the properties of ZnO(0001) layers grown on GaN(0001) templates and ZnO(0001) substrates. We show that deposition on GaN requires a two-step growth technique involving the growth of a low temperature nucleation layer before growing a high temperature epitaxial layer in order to obtain smooth ZnO films with excellent crystal quality and step-flow surface morphology. We obtained homoepitaxial ZnO(0001) films of structural quality and surface morphology that is comparable to the as-received substrates, and showed that a high growth temperature (≥1000°C) is needed in order to achieve step-flow growth mode. We performed n-type doping experiments, and established the conditions for which Indium effectively controls the n-type conductivity of ZnO films grown on GaN(0001) templates. A peak carrier concentration of 3.22x 10 19cm-3 and minimum sheet resistance of 97 O/square was achieved, while simultaneously maintaining good morphology and crystal quality. Finally, we present In-doped ZnO films implemented as p-contacts for GaN-based solar cells and LEDs

  20. Self-care and HIV/aids patients: nursing care systematization El autocuidado y el portador de SIDA: sistematización de la atención de enfermería Autocuidado e o portador do HIV/aids: sitematização da assistência de enfermagem

    Directory of Open Access Journals (Sweden)

    Joselany Áfio Caetano

    2006-06-01

    Full Text Available This research aimed at systematizing nursing care to HIV/aids patients in view of Orem's Self-care Deficit Nursing Theory, using the convergent-care method and the Self-Care Nursing Process. Subjects were thirteen HIV/AIDS patients attended at a non-governmental organization in Fortaleza/CE, Brazil. We used interview techniques, physical examination, observation and information records, with a structured instrument, addressing requisites related to universal self-care, development and health alterations. Self-care deficits corresponded to nineteen nursing diagnoses, named according to NANDA's Taxonomy II, ten of which were based on the requisites for universal self-care, five on the requisites for self-care related to development and four on the requisites for self-care related to health deviations. In care planning, goals were established and the system and health methods were selected, prioritizing support-education actions in order to engage HIV/aids patients in self-care.La finalidad de esta investigación es sistematizar la atención de enfermería al portador de SIDA, bajo la Teoría de Enfermería del Déficit de Auto-cuidado de Orem. Se usó la modalidad convergente asistencial, a través de la operación del Proceso de Enfermería de Auto Cuidado. Los sujetos fueron trece portadores de SIDA, atendidos en una organización no gubernamental en el municipio de Fortaleza/CE, Brasil. Para el desarrollo del estudio, se usaron técnicas de entrevista, de examen físico, de observación y de registro de las informaciones - con un instrumento estructurado - tratando de los requisitos de auto-cuidado universal, los referidos al desarrollo y los de alteraciones de la salud. Los déficit del auto cuidado correspondieron a diecinueve diagnósticos de enfermería, denominados según la Taxonomía II de NANDA, diez de los cuales dentro de los requisitos de auto cuidado universal; cinco en los requisitos de auto cuidado relativos al desarrollo y cuatro

  1. Influencia de factores objetivos y subjetivos en la disciplina Morfofisiología de la Carrera de Estomatología Influence of the objective and subjective factors in Morphology-physiology discipline in Dentistry Studies

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    Maritza Travieso Pérez

    2010-06-01

    Full Text Available La disciplina curricular de Morfofisiología se encuentra bajo la incidencia de los factores objetivos y subjetivos que limitan la estructuración y perfeccionamiento de los nuevos procesos educativos. Objetivo: valorar los factores objetivos y subjetivos que influyen en la dirección del proceso enseñanza aprendizaje de la disciplina Morfofisiología, limitando su estructuración y perfeccionamiento en la Carrera de Estomatología. Método: se realizó un estudio, en la disciplina Morfofisiología, de la Carrera de Estomatología de la provincia de Pinar del Río, en el período comprendido de septiembre de 2007 a enero de 2009. La muestra estuvo constituida por 142 estudiantes, de ellos, 131 de primer año y 101 de segundo. El método empleado fue la revisión y análisis de los documentos. Los datos obtenidos se procesaron utilizando los métodos y procedimientos que brinda la estadística descriptiva. Resultados: se encontraron más bajos niveles de rendimiento académico en la sede central con respecto a las sedes municipales, siendo las asignaturas Morfofisiología II y V las de más bajos resultados. Escasa participación de estudiantes en los exámenes de premio y menor calidad de los mismos en las sedes municipales. Conclusiones: que los resultados académicos en la disciplina Morfofisiología en la provincia de Pinar del Río, indican que el cambio educativo teniendo en cuenta los actuales contextos universitarios, implica necesariamente vincular a los estudiantes a los métodos productivos de enseñanza y a los servicios en la búsqueda de la excelencia educativa.The curricular discipline of Morphology-physiology is under the influence of objective and subjective factors which limit the structuring and improvement of the new educational process. Objective: to assess the objective and subjective factors that influence on the direction of the teaching-learning process of Morphology-physiology which limits its structuring and

  2. El edificio Botines de León. Cómo se hizo

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    González Moreno-Navarro, José Luis

    2002-12-01

    Full Text Available The authors provide historic data on the construction process of the Bolines Building and offer their interpretation of the reasons for the "style" Gaudí used for the facades and the volume of the whole. However; the main part is given over lo describing the structure of the building which they consider surprising. They explain the construction procedures -some of them remarkable-used by the architect in the foundations, structure and roof, including safety margins, according lo the geotechnical report drawn up in 1993, which substantiates the criticism by Gaudi's contemporaries regarding the foundations. It also shows that although the slender walls have stood up lo a hundred years of gravitational force. there is no safety margin. It aII explains that his original system for collecting and channeling rainwater on the roof -correct in it's structural design and construction- was not entirely advantageous for the occupants. The authors also draw attention to the way in which the restorers kept in mind the overall concept of the building and the care they look in its rehabilitation, although they had no alternative but lo correct "young " Gaudi and rectify all his constructional slips.Los autores del articulo aportan algunos datos históricos acerca del proceso de construcción del monumento, ofrecen su interpretación sobre las razones de cómo Gaudí compuso las fachadas y el volumen del conjunto y, principalmente, describen el edificio -al cual califican de sorprendente- desde el punto de vista estructural.Se explican los procedimientos constructivos -algunos bien singulares- utilizados por el arquitecto en cimientos, estructura y cubierta, reflejando el margen de seguridad que ofrecían según el informe geotécnico realizado en 1993. Éste ratifica, por ejemplo. que las criticas que recibieron en su día las cimentaciones eran justificados; demuestra, también, que a pesar de que el comportamiento durante los cien años que han durado las

  3. Diagnósticos de enfermagem em pacientes no período pós-operatório de cirurgias cardíacas Diagnósticos de enfermería en pacientes en el período postoperatorio de cirugías cardíacas Nursing diagnoses in patients in the postoperative period of cardiac surgery

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    Flávia Lamberti Pivoto

    2010-10-01

    Full Text Available OBJETIVO: Identificar, em conjunto com enfermeiras de uma Unidade de Tratamento Intensivo Pós-Operatória Cardiológica, diagnósticos de enfermagem presentes em pacientes no período pós-operatório de cirurgias cardíacas, com vistas à futura implementação do processo de enfermagem nessa unidade. MÉTODOS: Trata-se de um estudo qualitativo, ancorado na pesquisa convergente-assistencial. Os dados foram obtidos, nos registros de enfermagem de 20 pacientes submetidos à cirurgia cardíaca, no mês de abril de 2008, acrescidos da experiência profissional de seis enfermeiras participantes do grupo de convergência reunido durante cinco encontros. RESULTADOS: Foram estabelecidos 15 diagnósticos, segundo a Taxonomia II da North American Nursing Diagnosis Association, corroborados por outros autores. CONCLUSÃO: Identificar diagnósticos de enfermagem comuns em pacientes no pós-operatório de cirurgias cardíacas permite um direcionamento da assistência de enfermagem e subsidia o estabelecimento de intervenções fundamentadas e adequadas às necessidades individuais apresentadas por esses pacientes.OBJETIVO: Identificar en conjunto con las enfermeras, de una Unidad de Tratamiento Intensivo Postoperatorio Cardiológico, los diagnósticos de enfermería realizados en pacientes en el período postoperatorio de cirugías cardíacas, con la finalidad de, futuramente, implementar el proceso de enfermería en esa unidad. MÉTODOS: Se trata de un estudio cualitativo, basado en la investigación convergente-asistencial. Los datos fueron obtenidos de los registros de enfermería de 20 pacientes sometidos a cirugía cardíaca, en el mes de abril de 2008, acrecidos de la experiencia profesional de seis enfermeras participantes del grupo de convergencia que se reunió durante cinco encuentros. RESULTADOS: Fueron establecidos 15 diagnósticos, según la Taxonomía II de la North American Nursing Diagnosis Association, corroborados por otros autores

  4. Timomas malignos: A experiência do IPO do Porto e revisão da literatura Malignant thymomas: The experience of the Portuguese Oncological Institute, Porto, and literature review

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    Berta Sousa

    2007-07-01

    Full Text Available Introdução: Os tumores epiteliais tímicos (TET, a maioria timomas, são neoplasias desenvolvidas a partir das células epiteliais do timo e constituem cerca de 30% das massas do mediastino anterior em adultos. Os timomas são constituídos por células sem características citológicas de malignidade, sendo o comportamento maligno determinado pela invasão da cápsula e estruturas adjacentes. Estes tumores apresentam um amplo espectro de características clínicas e morfológicas, e as pequenas séries de doentes conhecidas tornam difícil o estabelecimento de um tratamento standard. Material e métodos: Efectuou-se um estudo retrospectivo dos doentes admitidos com diagnóstico de timoma no Instituto Português de Oncologia - Centro do Porto (IPO-Porto, de 1983 a 2004. Foram analisadas as suas características clínicas, classificação histológica segundo a OMS, o estadiamento de Masaoka, e a sua relação com as modalidades de tratamento. Procedeu-se à revisão dos registos clínicos destes doentes e revisão do material histológico para a classificação segundo critérios da OMS de 1999. Resultados: No IPO-Porto, entre 1983 e 2004, foram tratados 28 doentes com TET. Destes, 21 eram timomas invasivos, sendo estes o objecto deste estudo. Dos dados demográficos salienta-se que eram 11 homens, 10 mulheres, com uma idade mediana de 55 anos (24-79 anos. A classificação histológica da OMS foi a seguinte: 2 doentes (9,5% Tipo A, 6 (28,6% tipo AB, 4 (19% tipo B1, 2 (9,5% tipo B2, 7 (33,4% tipo B3. O estadiamento segundo Masaoka foi 9 doentes (42,8% com estádio II, 6 (28,6% com estádio III e 6 (28,6% com estádio IVa. A maioria dos doentes apresentava sintomas locais à apresentação, com apenas 1 doente com diagnóstico de aplasia eritrocitária e 5 com Mastenia gravis (MG. Os 6 doentes submetidos apenas a ressecção cirúrgica completa não tiveram evidência de recorrência da doença (2 tipo A-II, 2 tipo AB-II, 1 tipo B1-II, 1 tipo B

  5. Variações na apresentação fenotípica da escoliose idiopática do adolescente Discordancia fenotípica en gemelos monocigóticos Variations in the phenotypic presentation of adolescent idiopathic scoliosis

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    David Del Curto

    2010-03-01

    Full Text Available OBJETIVO: discutir quais elementos, de acordo com a literatura, são responsáveis pela discordância fenotípica em gêmeos monozigóticos. MÉTODOS: foram levantados os dados ambulatoriais de um par de gêmeas monozigóticas, que incluíram: idade no momento do diagnóstico, tipo de curva, ângulo de Cobb da deformidade na consulta inicial, início do tratamento e último acompanhamento, ápice da curva e ângulo de Cobb aferido nas imagens radiográficas em perfil. RESULTADOS: criança I: curva principal lombar à esquerda, com ângulo de Cobb entre T11-L4 de 17°, e curva torácica direita entre T5-T11 de 14°. Os ápices encontravam-se no disco L1-L2 e na vértebra T8, respectivamente. Um ano depois, se detectou progressão significativa da deformidade, com a curva lombar evoluindo para 24° (T11-L4 e a curva torácica para 23° (T5-T11. Criança II: curva toracolombar de pequena magnitude à direita, com ângulo de Cobb entre T9 e L3 de 18°. O ápice situava-se na vértebra de T12. Um ano depois, observou-se aumento da curva, com o ângulo de Cobb progredindo para 40°. CONCLUSÃO: não obstante a evidência da origem genética para o desenvolvimento da escoliose, admite-se a influência de outros fatores para sua manifestação e progressão. Na literatura, encontram-se algumas explicações para o desenvolvimento da doença, referentes à deficiência de tecidos estruturais encontrada em síndromes e condições específicas, crescimento assimétrico dos membros e tronco, alterações da configuração sagital da coluna vertebral e fatores ligados à natureza, como alimentação.OBJETIVO: discutir los elementos que, de acuerdo a la literatura, son responsables por la discordancia fenotípica en gemelos monocigóticos. MÉTODOS: fueron recogidos los datos de un par de pacientes gemelas monocigóticas, que incluyeron la edad al diagnóstico, el tipo de curva, el ángulo de Cobb de la deformidad en la presentación, al inició del

  6. Malignant thymomas – The experience of the Portuguese Oncological Institute, Porto, and literature review

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    Berta Sousa

    2007-07-01

    Full Text Available Introduction: Epithelial thymic tumours (ETT, which comprise the majority of thymomas, are neoplasias developed from the epithelial cells of the thymus and constitute around 30% of anterior mediastinal masses in adults. Thymomas consist of cells with no cytological characteristics of malignity; malignant behaviour is determined by invasion of the capsule and adjacent structures. These tumours present a broad spectrum of clinical and morphological characteristics and the small series of known patients makes establishing a standard treatment difficult. Material and methods: A retrospective study was made into thymoma diagnosed patients admitted to the Portuguese Oncology Institute in Porto (IPOPorto from 1983 to 2004. Clinical characteristics were analysed and a histological classification made in accordance with World Health Organization criteria, Masaoka staging, and their relation to treatment methods. A review of the clinical records of these patients was then made, as well as a review of histological material for classification in line with 1999 WHO criteria. Results: Twenty-eight ETT patients were treated at the IPO-Porto between 1983 and 2004. Of these, 21 had invasive thymomas and these are the subject of this study. Eleven subjects were male and 10 female, with a median age of 55 years (24-79 years. The WHO histological classification was as follows: 2 patients (9.5% type A, 6 (28.6% type AB, 4 (19% type B1, 2 (9.5% type B2, 7 (33.4% type B3. Masaoka staging was 9 patients (42.8% with stage II, 6 (28.6% with stage III and 6 (28.6% with stage IVa. The majority of patients had local symptoms, with only one subject diagnosed with erythrocyte aplasia and five with Myasthenia Gravis (MG.The 6 patients who were given complete surgical resection only showed no evidence of disease recurrence (2 type A-II, 2 type AB-II, 1 type B1-II, 1 type B2- IVa, with follow-up from 8-144 months. Ten patients with complete resection received adjuvant treatment

  7. Timomas malignos – A experiência do IPO do Porto e revisão da literatura

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    Berta Sousa

    2007-07-01

    úrgica completa não tiveram evidência de recorrência da doença (2 tipo A-II, 2 tipo AB-II, 1 tipo B1-II, 1 tipo B2-IVa, com follow-up variando entre 8 e 144 meses. 10 doentes com ressecção completa receberam tratamento adjuvante, 6 radioterapia (4 doentes B3-II, 2 doentes B3-III, 2 quimioterapia (AB-IVa e 2 radioterapia e quimioterapia (B1-IVa, B2-III. Apenas os 2 doentes que efectuaram quimioterapia adjuvante reci-divaram, aos 168 e 46 meses, e morreram aos 168 e 49 meses. Os restantes doentes que efectuaram tratamento adjuvante encontram-se sem evidência de doença. Dos 5 doentes com ressecção incompleta seguido de tratamento complementar (2 doentes AB-III, 2 B1-IVa, 1 B3-III, 3 morreram aos 11 meses (B3-III, aos 12 meses (B1-IVa e aos 241 meses (AB-III, este últi-mo por MG.Conclusões: Apesar de se tratar de uma pequena série, os factores preditivos de mau prognóstico foram a ressecção incompleta, estádio avançado e o subtipo histológico B3. É necessário investigar o papel do tratamento adjuvante e neoadjuvante no grupo de doentes com doença avançada e subtipo histológico B3.Rev Port Pneumol 2007; XIII (4: 553-585 Abstract: Introduction: Epithelial thymic tumours (ETT, which comprise the majority of thymomas, are neoplasias developed from the epithelial cells of the thymus and constitute around 30% of anterior mediastinal masses in adults. Thymomas consist of cells with no cytological characteristics of malignity; malignant behaviour is determined by invasion of the capsule and adjacent structures. These tumours present a broad spectrum of clinical and morphological characteristics and the small series of known patients makes establishing a standard treatment difficult.Material and methods: A retrospective study was made into thymoma diagnosed patients admitted to the Portuguese Oncology Institute in Porto (IPO-Porto from 1983 to 2004. Clinical characteristics were analysed and a histological classification

  8. Proteínas morfogenéticas ósseas associadas a osso esponjoso autógeno na reparação de falhas experimentais na calota craniana de coelhos (Oryctolagus cuniculus Bone morphogenetic proteins associated with autogenous bone graft in the reparation of calvarial experimental defects of rabbits (Oryctolagus cuniculus

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    B.S. Monteiro

    2007-12-01

    Full Text Available Foi avaliada a reparação óssea após implantação de proteínas morfogenéticas ósseas (BMP em diferentes concentrações e períodos de observação, carreadas por auto-enxerto ósseo esponjoso (EOE, em falhas ósseas, produzidas na região fronto-parietal do crânio de 20 coelhas. A falha I não foi preenchida, a II foi completamente preenchida com 3mg de EOE e as falhas III, IV, V e VI foram preenchidas com EOE associado a 0,5; 1; 2 e 5mg de BMP, respectivamente. Nas avaliações mesoscópicas, post mortem, verificou-se que, independentemente do período de tratamento, o preenchimento ósseo iniciou-se a partir das bordas para o centro e do fundo para a superfície das falhas. Na falha I manifestou-se o menor preenchimento ósseo quando comparada com as demais falhas, em todos os períodos, e nas que receberam 2mg de BMP exibiu-se a melhor cobertura óssea. Microscopicamente, verificou-se que, aos sete dias, o preenchimento ósseo iniciou-se a partir das bordas e do fundo da lesão, com mobilização e diferenciação de células provenientes do periósteo e das meninges, respectivamente e, nas avaliações subseqüentes, a atividade osteoblástica originou-se, também, de "ilhas de ossificação" semelhantes a centros de ossificação, localizadas no centro da falha. A formação trabecular aumentou, proporcionalmente, com a concentração utilizada de BMP, e a aposição e organização óssea aumentaram com o tempo de observação. Verificou-se também a presença de tecido cartilaginoso. A BMP associada ao EOE contribuiu para a formação de novo tecido ósseo, promovendo maior mobilização, diferenciação e organização celular, e abreviou o tempo de formação óssea, sugerindo processo de ossificação endocondral. Os melhores resultados foram observados com a associação de 2mg de BMP a 3mg de enxerto, e a adição de BMP, mesmo em menor quantidade, determinou precocidade de formação óssea. A maior quantidade de BMP n

  9. Diagnósticos de enfermagem da NANDA no período pós-parto imediato e tardio Diagnósticos de enfermería NANDA durante el puerperio temprano y tardío Nursing Diagnosis NANDA in Puerperium at the immediate and late

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    Flaviana Vieira

    2010-03-01

    Full Text Available Ao retornar à comunidade, no período pós-parto, a mulher necessita de atendimento de enfermagem sistematizado. Objetivou-se nesta pesquisa analisar a ocorrência de 22 diagnósticos de enfermagem de interesse no puerpério imediato e tardio. Trata-se de estudo descritivo, do qual participaram 40 puérperas. Realizou-se a coleta de dados no período de fevereiro a maio de 2008, no domicílio das participantes, mediante um encontro com entrevista, exame físico e observação. O julgamento clínico dos diagnósticos foi baseado na Taxonomia II da NANDA. Entre os diagnósticos identificados, destacaram-se: conhecimento deficiente; risco para infecção; integridade tissular prejudicada; amamentação eficaz; ansiedade; nutrição desequilibrada, menos do que as necessidades corporais; disposição para processos familiares melhorados; risco de integridade da pele prejudicada; e insônia. Foram encontrados indícios de novos diagnósticos: risco de amamentação interrompida, risco de amamentação ineficaz. Os resultados indicam áreas para o direcionamento das ações de enfermagem no pré-natal e puerpério e a necessidade de acompanhamento mais próximo da puérpera do que o previsto nas políticas de saúde.A su regreso a la comunidad después del parto, las mujeres necesitan cuidados de enfermería de forma sistemática El objetivo de esta investigación fue analizar con qué frecuencia se presentaron 22 diagnósticos de enfermería durante las etapas de puerperio inmediato y tardío. Este es un estudio descriptivo, en el que participaron 40 madres. Los datos fueron recopilados de febrero a mayo de 2008, en el hogar de los participantes, a través de una reunión en donde se realizaron entrevistas, exámenes físicos y observación. El juicio crítico del diagnóstico está basado en la taxonomía II de la North American Nursing Diagnosis Association (NANDA. Entre los diagnósticos identificados, destacaron los siguientes: Conocimientos

  10. Próba ukierunkowania rehabilitacji u pacjentów ze stwardnieniem rozsianym w zależności od typu klinicznego choroby = The attempt conditions for the rehabilitation of patients with multiple sclerosis, depending on the type of clinical disease

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    Wojciech Garczyński

    2016-07-01

      Autor korespondencyjny:   dr n. o zdr. Wojciech Garczyński Indywidualna Praktyka Fizjoterapeutyczna ul. Biskupa Bandurskiego 71/17 71-685 Szczecin w.garczynski@gmail.com   Słowa kluczowe: rehabilitacja, stwardnienie rozsiane.   Key words: rehabilitation, multiple sclerosis.       WSTĘP. Stwardnienie rozsiane (łac. sclerosis multiplex, SM jest to choroba o podłożu zapalno-demielinizacyjnym ośrodkowego układu nerwowego, w której dochodzi do wieloogniskowych zmian. Etiopatogeneza związana jest z uwarunkowaniami genetycznymi i immunologicznymi. Stwardnienie rozsiane może mieć przebieg z rzutami lub bez. Forma kliniczna pierwotnie postępująca (PPMS stwardnienia rozsianego występuje bez rzutów, pozostałe formy kliniczne: rzutowo – remisyjna (RRMS, wtórnie postępująca (SPMS i postępująco – nawracająca (PRMS charakteryzują się pojawianiem się rzutów choroby, forma łagodna (BNMS może występować bez rzutów. CEL BADAŃ. Głównym celem podjętych badań było poszukiwanie zależności pomiędzy zróżnicowaniem funkcji fizycznych chorych na stwardnienie rozsiane a typem klinicznym schorzenia. Ewentualne znalezienie takich zależności w konsekwencji pozwoliłoby na wczesne ukierunkowanie procesu rehabilitacji dostosowanej do potrzeb pacjentów z określonym typem klinicznym  choroby. MATERIAŁ I METODA. W badaniu wzięło udział 313 osób ze zdiagnozowanym stwardnieniem rozsianym, przebywających na czterotygodniowych turnusach rehabilitacyjnych w Centrum Rehabilitacji dla Osób Chorych na Stwardnienie Rozsiane im. Jana Pawła II w Bornym Sulinowie. Zastosowano metodę sondażu diagnostycznego z wykorzystaniem standaryzowanych kwestionariuszy, typowych do oceny funkcji u chorych na stwardnienie rozsiane (EDSS, MFIS, MDST, HADS, EQUI – SCAL. Do obliczeń statystycznych wykorzystano program Statistica 10 firmy StatSoft. WYNIKI. Uzyskano statystycznie istotne różnice w wieku zachorowania na stwardnienie rozsiane oraz w

  11. Strategie radzenia sobie z chorobą nowotworową w okresie chemioterapii = Coping strategies evaluated in oncological patients on chemotherapy treatment

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    Bożena Baczewska

    2017-02-01

      1 Katedra Interny z Zakładem Pielęgniarstwa Internistycznego Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie 2 Katedra Psychoterapii i Psychologii Zdrowia Katolicki Uniwersytet Lubelski im. Jana Pawła II. OTS Lublin 3 Katedra i Zakład Pielęgniarstwa Neurologicznego Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie 4 Katedra Chirurgii i Pielęgniarstwa Chirurgicznego Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie       Słowa kluczowe: strategie radzenia sobie z chorobą, choroba nowotworowa, chemioterapia   Key words: strategies for coping with the disease, cancer, chemotherapy     Streszczenie Wstęp. Chemioterapia będąc długim procesem leczenia, niesie za sobą szereg skutków ubocznych. Wiele skutków ubocznych działania cytostatyków wpływa na psychikę człowieka. Pacjent w tym okresie stosuje różne strategie radzenia sobie z chorobą, które pozwalają mu przetrwać trudne chwile. Materiał i metoda. Badaniem objęto 123 pacjentów poddanych chemioterapii Centrum Onkologii Ziemi Lubelskiej w Lublinie. Zastosowano Skalę Przystosowania Psychicznego do choroby nowotworowej Mini-MAC oraz autorski kwestionariusz. Wyniki badań. Respondenci w 55,5% wykazują cechy zaabsorbowania lękowego. Zdecydowana większość pacjentów ukazuje cechy ducha walki (83,61%. Większość badanych (75,02% nie wykazuje objawów bezradności i beznadziejności. Badani w 79,55% stosują zachowania zakwalifikowane do strategii pozytywnego przewartościowania. Częściej styl konstruktywny stosowały kobiety niż mężczyźni. Największe nasilenie stylu destrukcyjnego zanotowano dla osób chorych na nowotwory: narządów rodnych (36,26,  pęcherza (36,26 oraz sutka/piersi (34,71. Jeśli chodzi o styl konstruktywny, zaistniał on w każdym rodzaju choroby nowotworowej. Wnioski. 1. W badanej grupie pacjentów, poddanych chemioterapii dominują strategie ducha walki i pozytywnego przewartościowania, które są sk

  12. Żydzi w dyskursie Kościoła katolickiego

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    Marzena Makuchowska

    2016-01-01

    . Pozytywny obraz Żydów i judaizmu był konsekwentnie kreowany w naukach papieży Jana Pawła II i Benedykta XVI. Lingwistyczne środki podkreślają wspólnotę chrześcijan i Żydów (więź, bliskość, bracia, braterstwo, razem itd.. Papieże zobowiązują katolików do szanowania Żydów i pamięci Holokaustu, bezpośrednio zakazują jakichkolwiek przejawów antysemityzmu. W Polsce po 1989 roku antyżydowskie tendencje znów ożyły, szczególnie w kręgach tak zwanych radiomaryjnych. Ponownie Żydzi oskarżani są o powodowanie szkód Polsce i Polakom, a język tych twierdzeń bardzo przypomina dyskursy przedsoborowe.

  13. Strategie radzenia sobie z bólem pacjentów z przewlekłą chorobą internistyczną = Strategies of coping with pain in patients with chronic internal disease

    Directory of Open Access Journals (Sweden)

    Bożena Baczewska

    2017-02-01

      1 Katedra Interny z Zakładem Pielęgniarstwa Internistycznego Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie 2 Katedra Psychoterapii i Psychologii Zdrowia Katolicki Uniwersytet Lubelski im. Jana Pawła II. OTS Lublin 3 Katedra i Zakład Pielęgniarstwa Neurologicznego Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie 4 Katedra Chirurgii i Pielęgniarstwa Chirurgicznego Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie     Streszczenie Wstęp. Ból jest cennym objawem diagnostycznym, jednak w chwili kiedy przybiera charakter przewlekły wpływa negatywnie na każdy aspekt życie człowieka, zarówno biologiczny, psychiczny, jak również nie pozwala na pełnienie dotychczasowych ról społecznych. Ból w chorobach internistycznych jest najczęściej wskaźnikiem zaostrzenia choroby i zmusza do podejmowania działań, których celem jest jego łagodzenie. Działania te określa się jako strategie radzenia sobie z bólem. Celem badań było określenie strategii radzenia sobie z bólem pacjentów z przewlekłą chorobą internistyczną. Materiał i metoda. Badaniami objęto 200 pacjentów chorujących na przewlekłe choroby internistyczne, leczonych w Klinice Gastroenterologii z Pracownią Endoskopową oraz pacjentów Poradni Gastroenterologicznej oraz Reumatologicznej Przyklinicznej Przychodni Specjalistycznej Samodzielnego Szpitala Klinicznego Nr 4 w Lublinie. W badaniach posłużono się standaryzowanymi narzędziami badawczymi. W celach badawczych wykorzystano Kwestionariusz Strategii Radzenia Sobie z Bólem (CSQ, Skala wizualno – analogowa VAS oraz Kwestionariusz Autorski.  Wyniki badań. W badanej grupie wystąpiły wszystkie strategie radzenia sobie z bólem, do najczęściej stosowanych strategii należały modlenie się, zwiększona aktywność behawioralna jak również deklarowanie radzenia sobie. W wyniku przeprowadzonych badań stwierdzono istotny związek między nasileniem dolegliwości bólowych, wykszta

  14. Aldosterone synthase gene polymorphism in alimentary obesity, metabolic syndrome components, some secondary forms of arterial hypertension, pathology of the adrenals glands core (literature review

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    S.N. Koval

    2017-08-01

    Full Text Available Hormonal factors of adrenal origin belong to the pathophysiological mechanisms of the formation and progression of arterial hypertension (AH and should be consi­dered while developing differentiated approaches to the treatment and prevention of hypertensive states, their primary, secondary and resistant forms. The first thing we should point up is aldosterone (AL, enzyme aldosterone synthase (AS, which takes a direct part in the formation of this hormone, as well as gene polymorphisms of AS, which have not only molecular genetic, but also differential diagnostic and therapeutic significance for secondary forms of arterial hypertension, abdominal obesity (AO, metabolic syndrome (MS, adrenal pathology and other endocrine disorders. AL is a steroid (mineralocorticoid hormone of the adrenal cortex, which is synthesized from cholesterol (CH, mainly in the glomerular zone of the adrenal glands, is released under the action of angiotensin II (A II and potassium ions (K+. AL acti­vity is mediated through the corresponding mineralocorticoid receptors (MKR. The particular importance in AH and MS development belongs to AL activation and MKR density in adipocytes, this phenomenon is accompanied by increased expression of pro-inflammatory cytokines, leptin, an adipogenic effect, and the inhibition of MCR activity is accompanied by increased production of adiponectin, which is more pronounced in patients with AH. Aldosterone synthase, a mitochondrial human enzyme encoded by the CYP11B2 gene (cytochrome P450, family 11, subfamily B, polypeptide 2 is located on the 8th chromosome. AS belongs to the superfamily of cytochrome P450 and regulates the synthesis of AL hormone. The CYP11B2 gene encodes the key enzyme for the synthesis of AL 18-hydroxylase. In scientific papers, single nucleotide polymorphism (SNP of AS gene is often studied, such as 5312T, Intron 2, Lys-173/Arg; T-344C, 3097 C/A. 227 SNP of the AS gene were identified in different

  15. The San Niccolo' experimental area for studying the hydrology of coastal Mediterranean peatlands

    Science.gov (United States)

    Rossetto, Rudy; Barbagli, Alessio; Sabbatini, Tiziana; Silvestri, Nicola; Bonari, Enrico

    2015-04-01

    Starting from 1930, a large part of the Massaciuccoli Lake coastal area (Tuscany, Italy) has been drained for agricultural purposes by a complex network of artificial drains and pumping stations. In the drained areas, peat soils, with values of organic matter up to 50% in some cases, are largely present (Pistocchi et al., 2012). As a consequence of the human impact, environmental problems arose in the last 50 years: i. the eutrophication status of the Massaciuccoli lake caused by nutrient enrichment (N, P) in surface- and ground-water (Rossetto et al., 2010a); ii. the subsidence (2-3 m in 70 years) of the lake bordering areas due to soil compaction and mineralization (Rossetto et al., 2010b). As a potential solution to improve water quality and to decrease soil organic matter mineralization, a rewetted pilot experimental area of 15 ha with phyto-treatment functionalities has been set up. This pilot, adequately instrumented, now constitutes an open field lab to conduct research on the hydrology of coastal Mediterranean peatlands. Site investigation was performed and data on stratigraphy (from top on average: 1/2 m thick peat layer, 1/3 m organic matter-rich silt, 1/3 m stiff blue-gray clay, up to 30 m thick sand layer) and water (ground- and surface-water) quantity and quality were gathered and related to both local and regional groundwater flows. The inferred hydrological conceptual model revealed the pilot is set in a regional discharge area and the ground-water dependent nature of the agro-ecosystem, with mixing of waters with different origins. The site has been divided in three different phyto-treatment systems: a constructed wetland system, internally and externally banked in order to force water flow to a convoluted pattern where Phragmites australis L. and Thypha angustifolia L. constitute the sparse natural vegetation; a vegetation filter system based on the plantation of seven different no-food crops managed according to a periodic cutting and biomass

  16. Validação do diagnóstico de enfermagem Angústia Espiritual: análise por especialistas Validación del diagnóstico de enfermería Angustia Espiritual: análisis por especialistas Validation of the nursing diagnosis Spiritual Anguish: analysis by experts

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    Erika de Cássia Lopes Chaves

    2010-04-01

    Full Text Available OBJETIVO: Realizar a validação de conteúdo do diagnóstico de enfermagem Angústia espiritual. MÉTODOS: Utilizando o referencial metodológico proposto por Fehring, foi empregado um questionário semi-estruturado, respondido por uma amostra de 72 enfermeiros, para avaliação do título, definição e características definidoras do diagnóstico Angústia espiritual, bem como, sua disposição na Taxonomia II da North American Nursing Diagnosis Association. RESULTADOS: O melhor domínio para classificação do diagnóstico em estudo, segundo os enfermeiros peritos, é o Domínio 10; no entanto, suas classes requerem revisão. Espiritualidade prejudicada demonstrou ser um título adequado ao conceito investigado. A validação das características definidoras identificou sete delas como importantes indicadores clínicos do diagnóstico e apenas a característica não se interessa pela natureza foi considerada pouco relevante. O escore total do diagnóstico foi 0,72, sendo, portanto, considerado validado. CONCLUSÃO: Uma nova proposta apresentada ao fenômeno em estudo foi considerada pertinente. Este estudo pode oferecer subsídios para a validação clínica do diagnóstico investigado.OBJETIVO: Realizar la validación de contenido del diagnóstico de enfermería Angustia espiritual. MÉTODOS: Utilizando el marco metodológico propuesto por Fehring, fue empleado un cuestionario semi-estructurado, respondido por una muestra de 72 enfermeros, para evaluar el título, definición y características definidoras del diagnóstico Angustia espiritual, así como, la clasificación en la Taxonomía II de la North American Nursing Diagnosis Association. RESULTADOS: El mejor dominio para la clasificación del diagnóstico en estudio, según los enfermeros peritos, es el Dominio 10; sin embargo, sus clases requieren revisión. La Espiritualidad perjudicada demostró ser un título adecuado para el concepto investigado. La validación de las caracter

  17. Aspectos funcionais, microbiológicos e morfológicos intestinais em crianças infectadas pelo vírus da imunodeficiência humana Functional, microbiological and morphological intestinal findings among human immunodeficiency virus infected children

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    Christiane Araujo Chaves Leite

    2006-12-01

    Full Text Available RACIONAL: O trato gastrointestinal é freqüentemente acometido nas crianças infectadas pelo vírus da imunodeficiência humana, com importantes repercussões no seu estado nutricional e sobrevida. A maioria dos estudos relacionados a esse tema foi desenvolvida com adultos, sendo menos investigado o problema nas crianças OBJETIVOS: Estudar aspectos digestivo-absortivos, microbiológicos e morfológicos intestinais em crianças infectadas pelo vírus da imunodeficiência humana MATERIAL E MÉTODOS: Onze crianças infectadas pelo vírus da imunodeficiência humana, menores de 13 anos, pertencentes às categorias clínicas A, B ou C, divididas em dois grupos: cinco pacientes com relato atual ou recente de diarréia e seis pacientes sem diarréia nos 30 dias que antecederam à inclusão no estudo. Investigação proposta: biopsia de intestino delgado e reto para análise morfológica e microbiológica, coprocultura, protoparasitológico de fezes, pesquisa de rotavírus, micobactérias e Cryptosporidium; teste da D-xilose RESULTADOS: Todos os pacientes testados (9/11 apresentavam má absorção da D-xilose (8,4-24,4 mg/dL. Os achados histopatológicos de intestino delgado foram inespecíficos, representados em sua maioria, por enteropatia grau I a II (6/10. Em todos os casos foi constatado aumento do infiltrado celular do córion. As alterações histopatológicas do reto também foram inespecíficas, com presença de aumento do infiltrado celular do córion. A pesquisa de microorganismos enteropatogênicos só foi positiva em dois casos, sendo identificado Mycobacterium avium intracellulare e Cryptosporidium nas fezes CONCLUSÕES: Demonstrou-se alta prevalência (100% de má absorção intestinal em crianças infectadas pelo vírus da imunodeficiência humana, com ou sem diarréia. Não foi possível estabelecer correlações quanto à presença de agentes enteropatogênicos, má absorção intestinal, alterações morfológicas intestinais e

  18. Reglarea încărcăturii de rod la pomii de măr de soiul Golden Reinders prin diverse metode de rărire

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    Ananie PEȘTEANU

    2017-12-01

    ând aveau 1,5-2,0 cm în diametru; 3 stropire cu Geramid New, 1,5 l/ha, la căderea a 80% de petale +2-3 zile; 4 stropire cu Geramid New, 2,0 l/ha, la căderea a 80% de petale +2-3 zile; 5 două stropiri cu Geramid New, 1,0 l/ha +1,0 l/ha: prima stropire – la căderea a 80% de petale +2-3 zile, a II-a – la dimensiunea de 6 mm în diametru a fructului central. Cercetările s-au efectuat pe parcursul anilor 2015–2016. Pe parcursul cercetărilor s-a studiat cantitatea de inflorescenţe până la rarire şi după, cantitatea de fructe pe pom şi la 100 de inflorescenţe, producţia, greutatea şi diametrul medii ale unui fruct. S-a stabilit că tratarea cu Geramid New a diminuat cu 41,9-51,5% cantitatea de inflorescenţe legate, ceea ce a permis şi o amplasare mai raţională a fructelor într-o inflorescenţă. Cea mai mare producţie medie de fructe a fost înregistrată în varianta tratată cu Geramid New în doza de 1,5 l/ha – 50,69 t/ha ori cu 85,2% mai mult în comparaţie cu varianta martor.

  19. Method for developing arrangements for response to a nuclear or radiological emergency. Updating IAEA-TECDOC-953. Emergency preparedness and response. Publication date: October 2003

    International Nuclear Information System (INIS)

    2003-09-01

    Response (EPR) series is an update to IAEA-TECDOC-953. It aims to: fulfil in part the IAEA's function under article 5.a(ii) of the Assistance Convention, and to provide a compendium of best practice for planners aiming both to comply with the Requirements and to improve their own capabilities for responding to radiation emergencies, while the Secretariat facilitates consensus on formal guidance for meeting the Safety Requirements. The publication incorporates material from existing IAEA emergency preparedness Safety Guides updating it to be consistent with the Requirements, to incorporate best practice, the results of research and the latest lessons identified in past emergencies, and to reflect relevant issues of international law. It provides a practical source of information relevant to the development of an integrated national, local and operator capability for emergency response based on the potential nature and magnitude of the risk. In order to apply the method described in this publication, emergency planners should have a good understanding of the basic principles for response to a nuclear or radiological emergency. They should review the relevant international guidance beforehand. This publication provides information concerning methodologies, techniques and available results of research relating to response to nuclear or radiological emergencies. It also provides a practical, step-by-step method for developing integrated operator, local and national capabilities for emergency response. It does not provide IAEA endorsed guidance or recommendations because this material has not undergone the process of peer reviews needed to become part of the IAEA Safety Standards Series. This publication concerns preparations for radiation emergencies. The range of potential radiation emergencies of concern is enormous, extending from a major reactor emergency to emergencies involving lost or stolen radioactive material. This method covers planning for the entire range. The

  20. EDITORIAL - ARQUIVOLOGIA

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    José Maria Jardim

    2011-01-01

    Full Text Available Os novos modos de produção, uso e preservação da informação e os desafios políticos e científicos que estes impõem à sociedade e ao Estado são marcas do complexo cenário contemporâneo. Nesse quadro histórico, a Arquivologia talvez vivencie hoje um momento tão relevante quanto o da sua institucionalização no século XIX e sua reconfiguração a partir da metade do século passado.Em países como o Brasil, historicamente à margem das grandes matrizes de pensamento e práticas arquivísticas, constatamos ainda hoje a justaposição desses momentos. Lidamos com dificuldades típicas de arquivos do século XIX, buscamos a adoção de padrões de gestão de documentos desenhados após a II Guerra Mundial e nos confrontamos com as possibilidades e problemas, cotidianamente renovadas, oferecidas pelas tecnologias da informação e da comunicação.No Brasil, se há evidências de crescimento significativo na produção do conhecimento arquivístico nos últimos anos, ainda são ostensivas as lacunas na sua difusão. Contamos com mais teses, dissertações, pesquisas e congressos, paralelamente a uma ampliação significativa dos cursos de graduação em Arquivologia. Supõe-se, portanto, que a demanda por conhecimento arquivístico, nessa nova realidade, seja crescente. Essa produção é fundamental para ampliarmos os instrumentos teóricos e metodológicos que respaldem a adequada intervenção do arquivista num universo empírico cada vez mais complexo.Além desses aspectos, no momento em que a Universidade Federal de Santa Catarina assume a criação do Curso de Graduação em Arquivologia, por iniciativa do Departamento de Ciência da Informação, parece-nos muito oportuno que a Encontros Bibli - Revista Eletrônica de Biblioteconomia e Ciência da Informação dedique um número especial à Arquivologia.Motivados pelos editores da Encontros Bibli, mobilizamos colegas que gentilmente atenderam ao nosso convite e contribuíram com

  1. Editorial - Arquivologia 10.5007/1518-2924.2011v16nesp1pi

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    José Maria Jardim

    2011-06-01

    Full Text Available Arquivologia Os novos modos de produção, uso e preservação da informação e os desafios políticos e científicos que estes impõem à sociedade e ao Estado são marcas do complexo cenário contemporâneo. Nesse quadro histórico, a Arquivologia talvez vivencie hoje um momento tão relevante quanto o da sua institucionalização no século XIX e sua reconfiguração a partir da metade do século passado. Em países como o Brasil, historicamente à margem das grandes matrizes de pensamento e práticas arquivísticas, constatamos ainda hoje a justaposição desses momentos. Lidamos com dificuldades típicas de arquivos do século XIX, buscamos a adoção de padrões de gestão de documentos desenhados após a II Guerra Mundial e nos confrontamos com as possibilidades e problemas, cotidianamente renovadas, oferecidas pelas tecnologias da informação e da comunicação. No Brasil, se há evidências de crescimento significativo na produção do conhecimento arquivístico nos últimos anos, ainda são ostensivas as lacunas na sua difusão. Contamos com mais teses, dissertações, pesquisas e congressos, paralelamente a uma ampliação significativa dos cursos de graduação em Arquivologia. Supõe-se, portanto, que a demanda por conhecimento arquivístico, nessa nova realidade, seja crescente. Essa produção é fundamental para ampliarmos os instrumentos teóricos e metodológicos que respaldem a adequada intervenção do arquivista num universo empírico cada vez mais complexo. Além desses aspectos, no momento em que a Universidade Federal de Santa Catarina assume a criação do Curso de Graduação em Arquivologia, por iniciativa do Departamento de Ciência da Informação, parece-nos muito oportuno que a Encontros Bibli - Revista Eletrônica de Biblioteconomia e Ciência da Informação dedique um número especial à Arquivologia. Motivados pelos editores da Encontros Bibli, mobilizamos colegas que gentilmente atenderam ao nosso convite e

  2. De Fábrica 'fundo de quintal' a empresa multinacional: o caso de uma aliança ítalo-brasileira sob o enfoque da abordagem estruturacionista da estratégia como prática De fábrica 'fondo de patio' a una empresa multinacional: el estudio de caso de una alianza ítalo-brasileña en el enfoque estructuracionista de la estrategia-como-práctica From home industry to multinational company: a case study of an Italian-Brazilian alliance under the focus of the structurationist approach of strategy-as-practice

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    Maísa Gomide Teixeira

    2012-08-01

    Full Text Available O objetivo deste artigo é investigar indícios estruturacionistas, decorrentes de uma aliança estratégica interorganizacional, que possam ter resultado na mudança de uma fábrica fundo de quintal para uma empresa multinacional. Atingiu-se esse objetivo realizando um estudo de caso na empresa subsidiária brasileira do setor de máquinas e componentes para móveis, atual líder do mercado. Atentou-se para as considerações de Johanson e Vahlne (2006, com relação às implicações dos relacionamentos interorganizacionais em termos de aprendizagem e oportunidades. Concordando com as crescentes exigências para elucidar a prática estratégica no cotidiano das empresas, adotou-se a abordagem de estratégia como prática em complementaridade com a teoria da estruturação para balizar o exame à indispensável ligação entre pessoas, atividades e o contexto mais amplo. Os resultados destacam diversas alterações nas atividades da empresa filial permeando as seguintes etapas da aliança: (i pré-aliança; (ii durante a parceria; e (iii após a joint-venture. Para ilustrar como os elementos de práxis, práticas e praticantes estariam relacionados nessas diferentes fases do relacionamento interorganizacional, uma adaptação do gráfico de Whittington (2006 é proposta. Conclui-se apresentando um quadro com as principais atividades e ferramentas envolvidas na adaptação da empresa ao longo da aliança, entre as quais se enfatizam as práticas de mobilidade dos funcionários e do compromisso de relacionamento. Para melhor entender a forma como as alianças estratégicas afetam as empresas de bens de capital e verificar se há um padrão recorrente em termos do envolvimento de práticas, práxis e praticantes nas etapas de relacionamento, semelhante ao que está se propondo, considera-se apropriado realizar um trabalho comparativo. Dessa forma, poder-se-ia fazer inferências sobre as condições de escopo e transferibilidade.El objetivo de este

  3. Freinet en España (1926-1939 - Freinet in Spain (1926-1939

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    José Luis Hernández Huerta

    2012-03-01

    future truncated by the beginning of the civil war. This research is about the Spanish receipt from the Modern School, the advertising and diffusion of those ideas, the itinerary followed by the spanish's freynet movement during it expansion and Franco’s government. Likewise, this paper presents a profile of the freynet’s teachers.Key-words: Freinet; Spain; Second Republic; purificacion; pedagogical renovation; modern school.   FREINET EN ESPAÑA (1926-1939ResumenLos postulados sobre educación de Celestín Freinet, en su empeño de dotar a la Cooperativa de Enseñanza Laica - CEL - de un carácter internacional, trascendieron pronto las fronteras francesas. España no fue ajena a tal influencia y, muy pronto, la propuesta educativa de aquél fue bien acogida, aunque contó, en un primer momento, con escasa difusión y menor aplicación. Fueron los vientos de renovación pedagógica propiciados por la II República quienes dieron impulso y alentaron la práctica de las novedosas técnicas educativas provenientes de Francia. Así, el incipiente movimiento freinetiano español fue tomando cuerpo y, en poco tiempo, contó con un batallón de maestros francotiradores, una sólida organización y un futuro prometedor, truncado por el comienzo de la guerra civil. En esta investigación se indaga, novedosamente, en la recepción española de la Escuela Moderna, en la publicidad y difusión de éstas, en el itinerario seguido por el movimiento freinetiano español en su expansión y en la depuración franquista del mismo. Asimismo, se presenta un bosquejo del perfil de los maestros integrantes del movimiento freinetiano español.Palabras-clave: Freinet; España; II República; depuración; renovación pedagógica; escuela moderna.  FREINET EN ESPAGNE (1926-1939ResuméLes principes de l'éducation de Célestin Freinet, dans un effort pour fournir l'Éducation Coopérative Laïque - CEL - de caractère international, dès trans-cendé les frontières de la France. L

  4. Situación del sarampión en Colombia

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    Gloria Rey

    2004-03-01

    Full Text Available

    Los países de las Américas han realizado grandes progresos en la interrupción de la transmisión del virus autóctono de sarampión. En el 2002 se confirmaron 2584 casos de sarampión y en el 2003 se presenta el registro histórico más bajo en la Región de 104 casos confirmados; hasta la semana epidemiológica 26 del 2004 se han confirmado 85 casos. En 1994 Colombia se comprometió a alcanzar la meta de eliminación del virus de sarampión, basándose básicamente en una estrategia de vacunación que incluye tres componentes: i campaña masiva de puesta al día, ii vacunación de rutina en el programa regular y iii campañas de seguimiento. Desde 1996 hasta el año 2003, las coberturas nacionales de vacunación con triple viral (SRP han oscilado entre el 78.5% en 1999 y el 94% en 1996, con un promedio de 88%; durante los últimos tres años se han hecho grandes esfuerzos para que se mantengan por encima del 90%; es así como se ha alcanzado el 91%, 93.3% y 92.8% en los años 2001, 2002 y 2003 respectivamente. En Colombia en 1993 se presentó una epidemia de 5.000 casos, 48 muertes y una tasa de incidencia de 28 / 100.000 habitantes. Durante los últimos 10 años la notificación de casos sospechosos al sistema de vigilancia de sarampión (MESS ha presentado un promedio de 2132 casos, con un rango de 625 en 1997 a 6311 en 2002. En el periodo de 1996 - 2001 el número de casos confirmados por laboratorio fue inferior a 10 casos por año, en el 2002 se presentó la última epidemia de sarampión en el país con la confirmación de 140 casos. El caso primario se presentó en una niña de 7 años quién había tenido contacto con casos febriles eruptivos en la ciudad de Maracaibo (Venezuela, país que estaba presentando una epidemia de sarampión por reintroducción del virus desde Europa. El último caso confirmado se presentó en la semana 39 del 2002, y finalmente se

  5. Editorial

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    Irene Machado

    2008-11-01

    órico-cultural não propriamente dos meios, mas de procedimentos que colocam numa mesma esfera de construção, novas e velhas mí­dias. Tanto Manovich quanto Ziegfried estudam as novas mí­dias no fluxo das conquistas que marcaram a civilização ocidental. Por isso, os dois estudiosos recorrem à arqueologia. O segundo semestre de 2001 foi particularmente rico de eventos na área dos estudos de comunicação e da semiótica. Dentre as reuniões cientí­ficas realizadas, dois foram noticiados nessa edição. O IV Encontro Internacional sobre o Pragmatismo e o V Congresso Brasileiro de Semiótica. A II Mostra Interpoesia também mereceu espaço nessa sessão. Obras fundamentais foram lançadas enriquecendo os tí­tulos de nossa pesquisa acadêmica. Foram resenhados os livros sobre as matrizes do pensamento, de Lucia Santaella, sobre arquitetura urbana, de Lucrécia Ferrara, sobre a obra de Kellreuter fazem parte dessa galeria. Na sessão de projeto, Paulo Angerami apresenta sua pesquisa fotográfica com câmeras. Embora o projeto editorial de Galáxia tivesse concebido a sessão de notí­cias para o relato de eventos culturais, cientí­ficos e artí­sticos, a revista não se deixa de noticiar as perdas de pessoas ilustres. Com profundo pesar, publicamos aqui a notí­cia do falecimento de Thomas Sebeok, notável semioticista e membro do Comitê Cientí­fico de Galáxia. Sua partida pode nos privar de sua companhia mas não de seus ensinamentos dos quais jamais poderemos abdicar. Irene Machado Editora Cientí­fica