Swirl Coaxial Injector Testing with LOX/RP-J

Science.gov (United States)

Greene, Sandra Elam; Casiano, Matt

2013-01-01

Testing was conducted at NASA fs Marshall Space Flight Center (MSFC) in the fall of 2012 to evaluate the operation and performance of liquid oxygen (LOX) and kerosene (RP ]1) in an existing swirl coaxial injector. While selected Russian engines use variations of swirl coaxial injectors, component level performance data has not been readily available, and all previously documented component testing at MSFC with LOX/RP ]1 had been performed using a variety of impinging injector designs. Impinging injectors have been adequate for specific LOX/RP ]1 engine applications, yet swirl coaxial injectors offer easier fabrication efforts, providing cost and schedule savings for hardware development. Swirl coaxial elements also offer more flexibility for design changes. Furthermore, testing with LOX and liquid methane propellants at MSFC showed that a swirl coaxial injector offered improved performance compared to an impinging injector. So, technical interest was generated to see if similar performance gains could be achieved with LOX/RP ]1 using a swirl coaxial injector. Results would allow such injectors to be considered for future engine concepts that require LOX/RP ]1 propellants. Existing injector and chamber hardware was used in the test assemblies. The injector had been tested in previous programs at MSFC using LOX/methane and LOX/hydrogen propellants. Minor modifications were made to the injector to accommodate the required LOX/RP ]1 flows. Mainstage tests were performed over a range of chamber pressures and mixture ratios. Additional testing included detonated gbombs h for stability data. Test results suggested characteristic velocity, C*, efficiencies for the injector were 95 ]97%. The injector also appeared dynamically stable with quick recovery from the pressure perturbations generated in the bomb tests.

LOX is a novel mitotic spindle-associated protein essential for mitosis.

Science.gov (United States)

Boufraqech, Myriem; Wei, Darmood; Weyemi, Urbain; Zhang, Lisa; Quezado, Martha; Kalab, Petr; Kebebew, Electron

2016-05-17

LOX regulates cancer progression in a variety of human malignancies. It is overexpressed in aggressive cancers and higher expression of LOX is associated with higher cancer mortality. Here, we report a new function of LOX in mitosis. We show that LOX co-localizes to mitotic spindles from metaphase to telophase, and p-H3(Ser10)-positive cells harbor strong LOX staining. Further, purification of mitotic spindles from synchronized cells show that LOX fails to bind to microtubules in the presence of nocodazole, whereas paclitaxel treated samples showed enrichment in LOX expression, suggesting that LOX binds to stabilized microtubules. LOX knockdown leads to G2/M phase arrest; reduced p-H3(Ser10), cyclin B1, CDK1, and Aurora B. Moreover, LOX knockdown significantly increased sensitivity of cancer cells to chemotherapeutic agents that target microtubules. Our findings suggest that LOX has a role in cancer cell mitosis and may be targeted to enhance the activity of microtubule inhibitors for cancer therapy.

Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments.

Science.gov (United States)

Felker, A; Mosimann, C

2016-01-01

Spatiotemporal transgene regulation by transgenic DNA recombinases is a central tool for reverse genetics in multicellular organisms, with excellent applications for misexpression and lineage tracing experiments. One of the most widespread technologies for this purpose is Cre recombinase-controlled lox site recombination that is attracting increasing interest in the zebrafish field. Tol2-mediated zebrafish transgenesis provides a stable platform to integrate lox cassette transgenes, while the amenability of the zebrafish embryo to drug treatments makes the model an ideal candidate for tamoxifen-inducible CreERT2 experiments. In addition, advanced transgenesis technologies such as phiC31 or CRISPR-Cas9-based knock-ins are even further promoting zebrafish transgenesis for Cre/lox applications. In this chapter, we will first introduce the basics of Cre/lox methodology, CreERT2 regulation by tamoxifen, as well as the utility of Tol2 and other contemporary transgenesis techniques for Cre/lox experiments. We will then outline in detail practical experimental steps for efficient transgenesis toward the creation of single-insertion transgenes and will introduce protocols for 4-hydroxytamoxifen-mediated CreERT2 induction to perform spatiotemporal lox transgene regulation experiments in zebrafish embryos. Last, we will discuss advanced experimental applications of Cre/lox beyond traditional lineage tracing approaches. Copyright © 2016 Elsevier Inc. All rights reserved.

Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations.

Science.gov (United States)

McLellan, Micheal A; Rosenthal, Nadia A; Pinto, Alexander R

2017-03-02

The cre-loxP-mediated recombination system (the "cre-loxP system") is an integral experimental tool for mammalian genetics and cell biology. Use of the system has greatly expanded our ability to precisely interrogate gene function in the mouse, providing both spatial and temporal control of gene expression. This has been largely due to the simplicity of its use and its adaptability to address diverse biological questions. While the use of the cre-loxP system is becoming increasingly widespread, in particular because of growing availability of conditional mouse mutants, many considerations need to be taken into account when utilizing the cre-loxP system. This review provides an overview of the cre-loxP system and its various permutations. It addresses the limitations of cre-loxP technology and related considerations for experimental design, and it discusses alternative strategies for site-specific genetic recombination and integration. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

Options for human ``return to the moon'' using tomorrow's SSTO, ISRU, and LOX-augmented NTR technologies

Science.gov (United States)

Borowski, Stanley K.

1996-03-01

The feasibility of conducting human missions to the Moon is examined assuming the use of three ``high leverage'' technologies: (1) a single-stage-to-orbit (SSTO) launch vehicle, (2) ``in-situ'' resource utilization (ISRU)—specifically ``lunar-derived'' liquid oxygen (LUNOX), and (3) LOX-augmented nuclear thermal rocket (LANTR) propulsion. Lunar transportation system elements consisting of a LANTR-powered lunar transfer vehicle (LTV) and a chemical propulsion lunar landing/Earth return vehicle (LERV) are configured to fit within the ``compact'' dimensions of the SSTO cargo bay (diameter: 4.6 m/length: 9.0 m) while satisfying an initial mass in low Earth orbit (IMLEO) limit of ˜60 t (3 SSTO launches). Using ˜8 t of LUNOX to ``reoxidize'' the LERV for a ``direct return'' flight to Earth reduces its size and mass allowing delivery to LEO on a single 20 t SSTO launch. Similarly, the LANTR engine's ability to operate at any oxygen/hydrogen mixture ratio from 0 to 7 with high specific impulse (˜940 to 515 s) is exploited to reduce hydrogen tank volume, thereby improving packaging of the LANTR LTV's ``propulsion'' and ``propellant modules''. Expendable and reusable, piloted and cargo missions and vehicle designs are presented along with estimates of LUNOX production required to support the different mission modes.

Ex Luna Scientia: The Lunar Occultation Explorer (LOX)

Science.gov (United States)

Miller, Richard

2017-01-01

The Lunar Occultation Explorer (LOX) is a next-generation mission concept that provides new capabilities for time-domain astrophysics and established the Moon as a platform for nuclear astrophysics. Performance requirements are driven by Type-Ia supernova (SNeIa) science goals that seek to revel details of these profoundly radioactive objects, including their diversity. Primary science objectives include, but are not limited to, probing the fundamental thermonuclear physics processes, performing a census of progenitors and their explosion mechanisms, and evaluating the environmental conditions and intrinsic systematics of these enigmatic objects. LOX provides new capabilities for all-sky, continuous monitoring in the MeV regime (0.1-10 MeV) by leveraging the Lunar Occultation Technique (LOT). Key benefits of the LOX/LOT approach include maximizing the ratio of sensitive-to-total deployed mass, low implementation risk, and demonstrated operational simplicity that leverages extensive experience with planetary orbital geochemistry investigations; LOX also enables long-term monitoring of MeV gamma-ray sources, a critical capability for SNeIa science. Proof-of-principle efforts validated all aspects of the mission using previously deployed lunar science assets, and led to the first high-energy gamma-ray source detected at the Moon. LOX mission performance, development progress, and expectations for science investigations will be presented.

The potential for targeting extracellular LOX proteins in human malignancy

DEFF Research Database (Denmark)

Mayorca Guiliani, Alejandro Enrique; Erler, Janine T

2013-01-01

The extracellular matrix (ECM) is the physical scaffold where cells are organized into tissues and organs. The ECM may be modified during cancer to allow and promote proliferation, invasion, and metastasis. The family of lysyl oxidase (LOX) enzymes cross-links collagens and elastin and, therefore......, is a central player in ECM deposition and maturation. Extensive research has revealed how the LOX proteins participate in every stage of cancer progression, and two family members, LOX and LOX-like 2, have been linked to metastasis, the final stage of cancer responsible for over 90% of cancer patient deaths...

Liquid Oxygen Rotating Friction Ignition Testing of Aluminum and Titanium with Monel and Inconel for Rocket Engine Propulsion System Contamination Investigation

Science.gov (United States)

Peralta, S.; Rosales, Keisa R.; Stoltzfus, Joel M.

2009-01-01

Metallic contaminant was found in the liquid oxygen (LOX) pre-valve screen of the shuttle main engine propulsion system on two orbiter vehicles. To investigate the potential for an ignition, NASA Johnson Space Center White Sands Test Facility performed (modified) rotating friction ignition testing in LOX. This testing simulated a contaminant particle in the low-pressure oxygen turbo pump (LPOTP) and the high-pressure oxygen turbo pump (HPOTP) of the shuttle main propulsion system. Monel(R) K-500 and Inconel(R) 718 samples represented the LPOTP and HPOTP materials. Aluminum foil tape and titanium foil represented the contaminant particles. In both the Monel(R) and Inconel(R) material configurations, the aluminum foil tape samples did not ignite after 30 s of rubbing. In contrast, all of the titanium foil samples ignited regardless of the rubbing duration or material configuration. However, the titanium foil ignitions did not propagate to the Monel and Inconel materials.

Human lunar mission capabilities using SSTO, ISRU and LOX-augmented NTR technologies: A preliminary assessment

Science.gov (United States)

Borowski, Stanley K.

1995-10-01

The feasibility of conducting human missions to the Moon is examined assuming the use of three 'high leverage' technologies: (1) a single-stage-to-orbit (SSTO) launch vehicle, (2) 'in-situ' resource utilization (ISRU)--specifically 'lunar-derived' liquid oxygen (LUNOX), and (3) LOX-augmented nuclear thermal rocket (LANTR) propulsion. Lunar transportation system elements consisting of a LANTR-powered lunar transfer vehicle (LTV) and a chemical propulsion lunar landing/Earth return vehicle (LERV) are configured to fit within the 'compact' dimensions of the SSTO cargo bay (diameter: 4.6 m/length: 9.0 m) while satisfying an initial mass in low Earth orbit (IMLEO) limit of approximately 60 t (3 SSTO launches). Using approximately 8 t of LUNOX to 'reoxidize' the LERV for a 'direct return' flight to Earth reduces its size and mass allowing delivery to LEO on a single 20 t SSTO launch. Similarly, the LANTR engine's ability to operate at any oxygen/ hydrogen mixture ratio from 0 to 7 with high specific impulse (approximately 940 to 515 s) is exploited to reduce hydrogen tank volume, thereby improving packaging of the LANTR LTV's 'propulsion' and 'propellant modules'. Expendable and reusable, piloted and cargo missions and vehicle designs are presented along with estimates of LUNOX production required to support the different mission modes. Concluding remarks address the issue of lunar transportation system costs from the launch vehicle perspective.

Total Hydrocarbon Content (THC) Testing in Liquid Oxygen (LOX)

Science.gov (United States)

Meneghelli, B. J.; Obregon, R. E.; Ross, H. R.; Hebert, B. J.; Sass, J. P.; Dirschka, G. E.

2016-01-01

The measured Total Hydrocarbon Content (THC) levels in liquid oxygen (LOX) systems at Stennis Space Center (SSC) have shown wide variations. Examples of these variations include the following: 1) differences between vendor-supplied THC values and those obtained using standard SSC analysis procedures; and 2) increasing THC values over time at an active SSC test stand in both storage and run vessels. A detailed analysis of LOX sampling techniques, analytical instrumentation, and sampling procedures will be presented. Additional data obtained on LOX system operations and LOX delivery trailer THC values during the past 12-24 months will also be discussed. Field test results showing THC levels and the distribution of the THC's in the test stand run tank, modified for THC analysis via dip tubes, will be presented.

Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy

Science.gov (United States)

Chen, Mingyi; Qiu, Hong; Lin, Xin; Nam, David; Ogbu-Nwobodo, Lucy; Archibald, Hannah; Joslin, Amelia; Wun, Ted; Sawamura, Tatsuya; Green, Ralph

2017-01-01

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL. Increased expression of LOX-1 has been demonstrated in atherosclerotic lesions and diabetic vasculopathy. In this study, we investigate the expression of LOX-1 receptor in sickle cell disease (SCD) vasculopathy. Expression of LOX-1 in brain vascular endothelium is markedly increased and LOX-1 gene expression is upregulated in cultured human brain microvascular endothelial cells by incubation with SCD erythrocytes. Also, the level of circulating soluble LOX-1 concentration is elevated in the plasma of SCD patients. Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of SCD vasculopathy. Soluble LOX-1 concentration in SCD may provide a novel biomarker for risk stratification of sickle cell vascular complications. PMID:27519944

Virtual Dual inhibition of COX-2 / 5-LOX enzymes based on binding properties of alpha-amyrins, the anti-inflammatory compound as a promising anti-cancer drug

Science.gov (United States)

Ranjbar, Mohammad Mehdi; Assadolahi, Vahideh; Yazdani, Mohsen; Nikaein, Donya; Rashidieh, Behnam

2016-01-01

Hydro-alcoholic fruit extract of Cordia myxa was considerably effective on curing acute inflammation in mouse model. Previous studies suggested significant anti-inflammatory activities as well as potential anticancer agent of α-amyrins in seeds. Inhibition of Cyclooxygenase-2 (COX-2) and 5-Lipooxygenase (5-LOX) is significant in cancer prevention and therapeutics although this inhibition with chemo-drugs has its own side-effects. It is shown that these enzymes pathways are related to several cancers including colon, breast and lung cancer. This study was conducted based on Cordia species' α-amyrins as a safer natural anti-cancer compound for inhibition of COX-2 and 5-LOX enzymes by molecular docking. The X-ray crystal structure of COX2 / 5-LOX enzymes and α-amyrins was retrieved and energetically minimized respectively. The binding site and surface of enzymes were detected. Docking studies were performed by AutoDock 4.2 using Lamarckian genetic algorithm (LGA). Finally drug likeness, molecular pharmacokinetic properties and toxicity of α-amyrins was calculated. Molecular Docking revealed hydrogen and hydrophobic interactions between α-amyrins with both active sites of COX-2 and 5-LOX enzymes. Interestingly, it covalently bonded to Fe cofactor of 5-LOX enzyme and chelated this molecule. Base on binding energies (∆G) α-amyrin has more inhibitory effects on 5-LOX (-10.45 Kcal/mol) than COX-2 (-8.02 Kcal/mol). Analysis of molecular pharmacokinetic parameters suggested that α-amyrins complied with most sets of Lipinski's rules, and so it could be a suitable ligand for docking studies. Eventually, bioactivity score showed α-amyrins possess considerable biological activities as nuclear receptor, enzyme inhibitor, GPCR and protease inhibitor ligand. These results clearly demonstrate that α-amyrins could act as potential highly selective COX-/5-LOX inhibitor. Also, it is a safe compound in comparison with classical non-steroidal anti-inflammatory drugs (NSAIDs

Role of LOX3 Gene in Alleviating Adverse Effects of Drought and Pathogens in Rice

Institute of Scientific and Technical Information of China (English)

LIU Nan-nan; JIANG Ling; ZHANG Wen-wei; LIU Ling-long; ZHAI Hu-qu; WAN Jian-min

2008-01-01

Lipoxygenase 3 (LOX3) is a major component of the LOX isozymes in mature rice seeds. To investigate the role of LOX3 gene under stresses, a plant expression vector containing antisense cDNA of LOX3 was constructed. Rice varieties Wuyunjing 7 and Kasalath were transformed by the Agrobacterium-mediated method and transgenic rice plants were generated. PCR and Southern blot results showed that the antisense LOX3 gene was integrated into the rice genome. Analyses of embryo LOX3 deletion and semi-quantitative RT-PCR confirmed the antisense suppression of LOX3 gene in transgenic plants. The T2 antisense plants of LOX3 were sensitive to drought stress, rice blast and bacterial blight compared with non-transgenic plants. These results suggest that the LOX3 gene might function in response to stresses.

[Discover potential inhibitors of 5-LOX and LTA4H from Rhei Radix et Rhizoma, Notopterygii Rhizoma et Radix and Genitana Macrophyllae Radix based on molecular simulation methods].

Science.gov (United States)

Gu, Yu; Zhang, Xu; Chen, Yan-Kun; Zhao, Bo-Wen; Zhang, Yan-Ling

2017-12-01

5-lipoxygenase (5-LOX) and leukotriene A4 hydrolase (LTA4H), as the major targets of 5-LOX branch in the arachidonic acid (AA) metabolic pathway, play an important role in the treatment of inflammation. Rhei Radix et Rhizoma, Notopterygii Rhizoma et Radix and Genitana Macrophyllae Radix have clear anti-inflammation activities. In this paper, the targets of 5-LOX and LTA4H were used as the research carrier, and Hiphop module in DS4.0 (Discovery studio) was used to construct ingredients database for preliminary screening of three traditional Chinese medicines based on target inhibitor pharmacophore, so as to obtain 5-LOX and LTA4H potential active ingredients. The ingredients obtained in initial pharmacophore screening were further screened by using CDOCKER module, and the screening rules were established based on the score of initial compound and the key amino acids to obtain 12 potential 5-LOX inhibitors and 7 potential LTA4H inhibitors. To be more specific, the potential 5-LOX inhibitors included 6 ingredients in Rhei Radix et Rhizoma, such as procyanidins B2-3,3'-O-double gallate and revandchinone 2; four ingredients in notopterygium, such as dodecanoic acid and so on. On the other hand, potential LTA4H inhibitors included revandchinone 1, revandchinone 4 in Rhei Radix et Rhizoma, tridecanoic acid, tetracosanoic acid and methyl eicosanoate in Notopterygii Rhizoma et Radix, montanic acid methyl ester and N-docosanoyl-O-aminobenzoate in Genitana Macrophyllae Radix and so on. The molecular simulation methods were highly efficient and time-saving to obtain the potential inhibitors of 5-LOX and LTA4H, which could provide assistance for discovering the chemical quality indicators of anti-inflammatory efficacy of three Chinese herbs, and may be helpful to promote the whole-process quality control of three Chinese herbs. Copyright© by the Chinese Pharmaceutical Association.

Fish's Muscles Distortion and Pectoral Fins Propulsion of Lift-Based Mode

Science.gov (United States)

Yang, S. B.; Han, X. Y.; Qiu, J.

As a sort of MPF(median and/or paired fin propulsion), pectoral fins propulsion makes fish easier to maneuver than other propulsion, according to the well-established classification scheme proposed by Webb in 1984. Pectoral fins propulsion is classified into oscillatory propulsion, undulatory propulsion and compound propulsion. Pectoral fins oscillatory propulsion, is further ascribable to two modes: drag-based mode and lift-based mode. And fish exhibits strong cruise ability by using lift-based mode. Therefore to robot fish design using pectoral fins lift-based mode will bring a new revolution to resources exploration in blue sea. On the basis of the wave plate theory, a kinematic model of fish’s pectoral fins lift-based mode is established associated with the behaviors of cownose ray (Rhinoptera bonasus) in the present work. In view of the power of fish’s locomotion from muscle distortion, it would be helpful benefit to reveal the mechanism of fish’s locomotion variation dependent on muscles distortion. So this study puts forward the pattern of muscles distortion of pectoral fins according to the character of skeletons and muscles of cownose ray in morphology and simulates the kinematics of lift-based mode using nonlinear analysis software. In the symmetrical fluid field, the model is simulated left-right symmetrically or asymmetrically. The results qualitatively show how muscles distortion determines the performance of fish locomotion. Finally the efficient muscles distortion associated with the preliminary dynamics is induced.

Total hydrocarbon content (THC) testing in liquid oxygen (LOX) systems

Science.gov (United States)

Meneghelli, B. J.; Obregon, R. E.; Ross, H. R.; Hebert, B. J.; Sass, J. P.; Dirschka, G. E.

2015-12-01

The measured Total Hydrocarbon Content (THC) levels in liquid oxygen (LOX) systems at Stennis Space Center (SSC) have shown wide variations. Examples of these variations include the following: 1) differences between vendor-supplied THC values and those obtained using standard SSC analysis procedures; and 2) increasing THC values over time at an active SSC test stand in both storage and run vessels. A detailed analysis of LOX sampling techniques, analytical instrumentation, and sampling procedures will be presented. Additional data obtained on LOX system operations and LOX delivery trailer THC values during the past 12-24 months will also be discussed. Field test results showing THC levels and the distribution of the THC's in the test stand run tank, modified for THC analysis via dip tubes, will be presented.

Numerical analysis of flow and heat transfer in the VAFB LOX storage Dewar tank

Science.gov (United States)

Tam, L. T.; Singhal, A. K.

1984-01-01

The present report describes numerical simulation of three-dimensional transient distributions of velocity and temperature of liquid oxygen (LOX) in the LOX Dewar tank of Vendenberg Air Force Base (VAFB). The present analyses cover the replenish time period only. Four test cases have been considered. For all four cases, the input boundary conditions are comprised of LOX facility heat loads, drain flow rates, recirculation flow rates and dewar heating. All the quantities are prescribed as functions of time. The first two test cases considered sensitivity of results to the computational grid. In Case 3, system heat load was changed, while in Case 4, a lower LOX level was specified. Cases 1 and 2 showed that the temperatures were not sensitive to the grid refinement. This provided a basic check on the numerical model. Cases 3 and 4 showed that the thermal boundary layer motion near the tank surface becomes more significant at the late time, e.g., 5 1/2 hours from replenish start. Comparison between results of Cases 3 and 4 showed, as expected, that the smaller initial LOX volume given in Case 4, results in higher temperature level. All calculated velocity and temperature distributions were found to be plausible.

[Spectral analysis of polyphenol oxidase (PPO) and lipoxygenase (LOX) treated by pulsed electric field].

Science.gov (United States)

Luo, Wei; Zhang, Ruo-Bing; Chen, Jie; Wang, Li-Ming; Guan, Zhi-Cheng; Jia, Zhi-Dong

2009-08-01

Inactivation effect of pulsed electric field (PEF) on polyphenol oxidase (PPO) and lipoxygenase (LOX) was investigated using a laboratory PEF system with a coaxial treatment chamber. Circular dichroism (CD) and fluorescence analysis were used to study the conformation change of the protein. The experimental results show that PPO and LOX can be effectively inactivated by the PEF treatment. Inactivation effect of PPO and LOX increases with the increase in the applied electric strength and the treatment time. Activity of PPO and LOX can be reduced by 60.3% and 21.7% at 20 kV x cm(-1) after being treated for 320 micros respectively. The decrease of the negative peaks (208 and 215 nm in PPO spectra, 208 nm and 218 nm in LOX spectra) in CD spectra of PPO and LOX shows that PEF treatment caused a loss of alpha-helix and increase in beta-sheet content, indicating that conformation changes occur in the secondary structure of PPO and LOX enzyme. This effect was strengthened as the applied electric field increased: alpha-helical content of PPO and LOX was 56% and 29% after being treated at 8 kV x cm(-1), however, when the electric field was increased up to 20 kV x cm(-1), alpha-helical content of PPO and LOX decreased to 21% and 16% respectively. The decrease rate of alpha-helix and increase rate of beta-sheet in PPO are higher than LOX, indicating that the second conformation of PPO is less resistant to PEF treatment than LOX. The fluorescence intensity of LOX increases after PEF treatment. At the same time, increasing the applied pulsed electric field increases the fluorescence intensity emitted. Fluorescence measurements confirm that tertiary conformation changes occur in the local structure of LOX. However the possible mechanism of the conformation change induced by the PEF treatment is beyond the scope of the present investigation.

Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype.

Science.gov (United States)

Tsai, Ching-Yi; Poon, Yan-Yuen; Chen, Chang-Han; Chan, Samuel H H

2017-10-01

The last two decades have seen the emergence of Cre-Lox recombination as one of the most powerful and versatile technologies for cell-specific genetic engineering of mammalian cells. Understandably, the primary concerns in the practice of Cre-Lox recombination are whether the predicted genome has been correctly modified and the targeted phenotypes expressed. Rarely are the physiological conditions of the animals routinely examined because the general assumption is that they are normal. Based on corroborative results from radiotelemetric recording, power spectral analysis, and magnetic resonance imaging/diffusion tensor imaging in brain-derived neurotrophic factor-floxed mice, the present study revealed that this assumption requires amendment. We found that despite comparable blood pressure and heart rate with C57BL/6 or Cre mice under the conscious state, floxed and Cre-Lox mice exhibited diminished baroreflex-mediated sympathetic vasomotor tone and cardiac vagal baroreflex. We further found that the capacity and plasticity of baroreflex of these two strains of mice under isoflurane anesthesia were retarded, as reflected by reduced connectivity between the nucleus tractus solitarii and rostral ventrolateral medulla or nucleus ambiguus. The identification of anomalous baroreflex functionality inherent in floxed and Cre-Lox mice points to the importance of incorporating physiological phenotypes into studies that engage gene manipulations such as Cre-Lox recombination. NEW & NOTEWORTHY We established that anomalous baroreflex functionality is inherent in floxed and Cre-Lox mice. These two mouse strains exhibited diminished baroreflex-mediated sympathetic vasomotor tone and cardiac vagal baroreflex under the conscious state, retarded capacity and plasticity of baroreflex under isoflurane anesthesia, and reduced connectivity between key nuclei in the baroreflex neural circuits. Copyright © 2017 the American Physiological Society.

Fission-Based Electric Propulsion for Interstellar Precursor Missions

International Nuclear Information System (INIS)

HOUTS, MICHAEL G.; LENARD, ROGER X.; LIPINSKI, RONALD J.; PATTON, BRUCE; POSTON, DAVID; WRIGHT, STEVEN A.

1999-01-01

This paper reviews the technology options for a fission-based electric propulsion system for interstellar precursor missions. To achieve a total ΔV of more than 100 km/s in less than a decade of thrusting with an electric propulsion system of 10,000s Isp requires a specific mass for the power system of less than 35 kg/kWe. Three possible configurations are described: (1) a UZrH-fueled,NaK-cooled reactor with a steam Rankine conversion system,(2) a UN-fueled gas-cooled reactor with a recuperated Brayton conversion system, and (3) a UN-fueled heat pipe-cooled reactor with a recuperated Brayton conversion system. All three of these systems have the potential to meet the specific mass requirements for interstellar precursor missions in the near term. Advanced versions of a fission-based electric propulsion system might travel as much as several light years in 200 years

The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease

Directory of Open Access Journals (Sweden)

M. W Twigg

2012-01-01

Full Text Available Cardiovascular disease is the leading cause of death. The disease is due to atherosclerosis which is characterized by lipid and fat accumulation in arterial blood vessel walls. A key causative event is the accumulation of oxidised low density lipoprotein particles within vascular cells, and this is mediated by scavenger receptors. One such molecule is the LOX-1 scavenger receptor that is expressed on endothelial, vascular smooth muscle, and lymphoid cells including macrophages. LOX-1 interaction with OxLDL particles stimulates atherosclerosis. LOX-1 mediates OxLDL endocytosis via a clathrin-independent internalization pathway. Transgenic animal model studies show that LOX-1 plays a significant role in atherosclerotic plaque initiation and progression. Administration of LOX-1 antibodies in cellular and animal models suggest that such intervention inhibits atherosclerosis. Antiatherogenic strategies that target LOX-1 function using gene therapy or small molecule inhibitors would be new ways to address the increasing incidence of vascular disease in many countries.

LOX: Inferring level of expression from diverse methods of census sequencing

KAUST Repository

Zhang, Zhang

2010-06-10

Summary: We present LOX (Level Of eXpression) that estimates the Level Of gene eXpression from high-throughput-expressed sequence datasets with multiple treatments or samples. Unlike most analyses, LOX incorporates a gene bias model that facilitates integration of diverse transcriptomic sequencing data that arises when transcriptomic data have been produced using diverse experimental methodologies. LOX integrates overall sequence count tallies normalized by total expressed sequence count to provide expression levels for each gene relative to all treatments as well as Bayesian credible intervals. © The Author 2010. Published by Oxford University Press. All rights reserved.

LOX: Inferring level of expression from diverse methods of census sequencing

KAUST Repository

Zhang, Zhang; Ló pez-Girá ldez, Francesc Francisco; Townsend, Jeffrey P.

2010-01-01

Summary: We present LOX (Level Of eXpression) that estimates the Level Of gene eXpression from high-throughput-expressed sequence datasets with multiple treatments or samples. Unlike most analyses, LOX incorporates a gene bias model that facilitates integration of diverse transcriptomic sequencing data that arises when transcriptomic data have been produced using diverse experimental methodologies. LOX integrates overall sequence count tallies normalized by total expressed sequence count to provide expression levels for each gene relative to all treatments as well as Bayesian credible intervals. © The Author 2010. Published by Oxford University Press. All rights reserved.

Double transduction of a Cre/LoxP lentiviral vector: a simple method to generate kidney cell-specific knockdown mice.

Science.gov (United States)

Nam, Bo Young; Kim, Dong Ki; Park, Jung Tak; Kang, Hye-Young; Paeng, Jisun; Kim, Seonghun; Park, Jimin; Um, Jae Eun; Oh, Hyung Jung; Han, Seung Hyeok; Yoo, Tae-Hyun; Kang, Shin-Wook

2015-12-15

In a lentivirus-based gene delivery system, the incorporated gene is continuously expressed for a long time. In this study, we devised a simple way to knock down a specific gene in a kidney cell-specific pattern in adult mice by lentivirus-assisted transfer of short hairpin RNA (shRNA). Kidney collecting duct (CD)-specific aquaporin-3 (AQP3)-knockdown mice were generated by consecutive injection of Hoxb7-Cre-expressing lentivirus (LV-Hoxb7 Cre) and loxP-AQP3 shRNA-expressing lentivirus (LV-loxP shAQP3) in adult C57BL6/J mice. LV-Hoxb7 Cre was designed to express mCherry, while LV-loxP shAQP3 was designed with a floxed enhanced green fluorescent protein (EGFP)-tagged stop sequence, and thus EGFP would be expressed only in the absence of Cre recombination. In mice treated with LV-Hoxb7 Cre alone, mCherry protein expression, which indicates the presence of Cre recombinase, occurred only in CD cells. However, LV-loxP shAQP3 injection alone resulted in an increase in EGFP expression in all kidney cells, indicating the transcription of the floxed region. When LV-Hoxb7 Cre and LV-loxP shAQP3 were sequentially transduced, EGFP expression was attenuated while mCherry expression was sustained in CD cells, demonstrating a CD cell-specific recombination of the floxed region. AQP3 expression in mice injected with LV-Hoxb7 Cre or LV-loxP shAQP3 alone did not differ, but consecutive injection of LV-Hoxb7 Cre and LV-loxP shAQP3 significantly reduced AQP3 expression in CD cells. However, the expression levels of AQP3 were not altered in other cell types. Double transduction of Cre- and loxP-based lentivirus can easily generate kidney cell-specific knockdown mice, and this method might be applicable to other species. Copyright © 2015 the American Physiological Society.

LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis

DEFF Research Database (Denmark)

Cox, Thomas R; Bird, Demelza; Baker, Ann-Marie

2013-01-01

of metastastic tumor cells. We show that LOX-dependent collagen crosslinking is involved in creating a growth-permissive fibrotic microenvironment capable of supporting metastatic growth by enhancing tumor cell persistence and survival. We show that therapeutic targeting of LOX abrogates not only the extent...... to which fibrosis manifests, but also prevents fibrosis-enhanced metastatic colonization. Finally, we show that the LOX-mediated collagen crosslinking directly increases tumor cell proliferation, enhancing metastatic colonization and growth manifesting in vivo as increased metastasis. This is the first...... time that crosslinking of collagen I has been shown to enhance metastatic growth. These findings provide an important link between ECM homeostasis, fibrosis, and cancer with important clinical implications for both the treatment of fibrotic disease and cancer....

An Airbreathing Launch Vehicle Design with Turbine-Based Low-Speed Propulsion and Dual Mode Scramjet High-Speed Propulsion

Science.gov (United States)

Moses, P. L.; Bouchard, K. A.; Vause, R. F.; Pinckney, S. Z.; Ferlemann, S. M.; Leonard, C. P.; Taylor, L. W., III; Robinson, J. S.; Martin, J. G.; Petley, D. H.

1999-01-01

Airbreathing launch vehicles continue to be a subject of great interest in the space access community. In particular, horizontal takeoff and horizontal landing vehicles are attractive with their airplane-like benefits and flexibility for future space launch requirements. The most promising of these concepts involve airframe integrated propulsion systems, in which the external undersurface of the vehicle forms part of the propulsion flowpath. Combining of airframe and engine functions in this manner involves all of the design disciplines interacting at once. Design and optimization of these configurations is a most difficult activity, requiring a multi-discipline process to analytically resolve the numerous interactions among the design variables. This paper describes the design and optimization of one configuration in this vehicle class, a lifting body with turbine-based low-speed propulsion. The integration of propulsion and airframe, both from an aero-propulsive and mechanical perspective are addressed. This paper primarily focuses on the design details of the preferred configuration and the analyses performed to assess its performance. The integration of both low-speed and high-speed propulsion is covered. Structural and mechanical designs are described along with materials and technologies used. Propellant and systems packaging are shown and the mission-sized vehicle weights are disclosed.

Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.

Science.gov (United States)

Reddy, Nimmanapalli P; Aparoy, Polamarasetty; Reddy, T Chandra Mohan; Achari, Chandrani; Sridhar, P Ramu; Reddanna, Pallu

2010-08-15

Ten novel mono- and di-O-prenylated chalcone derivatives were designed on the basis of a homology derived molecular model of 5-lipoxygenase (5-LOX). The compounds were docked into 5-LOX active site and the binding characteristics were quantified using LUDI. To verify our theoretical assumption, the molecules were synthesized and tested for their 5-LOX inhibitory activities. The synthesis was carried out by Claisen-Schmidt condensation reaction of mono- and di-O-prenylated acetophenones with appropriate aldehydes. 5-LOX in vitro inhibition assay showed higher potency of di-O-prenylated chalcones than their mono-O-prenylated chalcone analogs. Compound 5e exhibited good inhibition with an IC(50) at 4 microM. The overall trend for the binding energies calculated and LUDI score was in good qualitative agreement with the experimental data. Further, the compound 5e showed potent anti-proliferative effects (GI(50) at 9 microM) on breast cancer cell line, MCF-7. Copyright 2010 Elsevier Ltd. All rights reserved.

Northrop Grumman TR202 LOX/LH2 Deep Throttling Engine Technology Project Status

Science.gov (United States)

Gromski, Jason; Majamaki, Annik; Chianese, Silvio; Weinstock, Vladimir; Kim, Tony S.

2010-01-01

NASA's Propulsion and Cryogenic Advanced Development (PCAD) project is currently developing enabling propulsion technologies in support of future lander missions. To meet lander requirements, several technical challenges need to be overcome, one of which is the ability for the descent engine(s) to operate over a deep throttle range with cryogenic propellants. To address this need, PCAD has enlisted Northrop Grumman Aerospace Systems (NGAS) in a technology development effort associated with the TR202 engine. The TR202 is a LOX/LH2 expander cycle engine driven by independent turbopump assemblies and featuring a variable area pintle injector similar to the injector used on the TR200 Apollo Lunar Module Descent Engine (LMDE). Since the Apollo missions, NGAS has continued to mature deep throttling pintle injector technology. The TR202 program has completed two series of pintle injector testing. The first series of testing used ablative thrust chambers and demonstrated igniter operation as well as stable performance at discrete points throughout the designed 10:1 throttle range. The second series was conducted with calorimeter chambers and demonstrated injector performance at discrete points throughout the throttle range as well as chamber heat flow adequate to power an expander cycle design across the throttle range. This paper provides an overview of the TR202 program, describing the different phases and key milestones. It describes how test data was correlated to the engine conceptual design. The test data obtained has created a valuable database for deep throttling cryogenic pintle technology, a technology that is readily scalable in thrust level.

TALEN-Based Mutagenesis of Lipoxygenase LOX3 Enhances the Storage Tolerance of Rice (Oryza sativa) Seeds.

Science.gov (United States)

Ma, Lei; Zhu, Fugui; Li, Zhenwei; Zhang, Jianfu; Li, Xin; Dong, Jiangli; Wang, Tao

2015-01-01

The deterioration of rice grain reduces the quality of rice, resulting in serious economic losses for farmers. Lipoxygenases (LOXs) catalyze the dioxygenation of polyunsaturated fatty acids with at least one cis,cis-1,4-pentadiene to form hydroperoxide, which is a major factor influencing seed longevity and viability. Recently, genome editing, an essential tool employed in reverse genetics, has been used experimentally to investigate basic plant biology or to modify crop plants for the improvement of important agricultural traits. In this study, we performed targeted mutagenesis in rice using transcription activator-like effector nucleases (TALENs) to improve seed storability. A modified ligation-independent cloning method (LIC) was employed to allow for the quick and efficient directional insertion of TALEN monomer modules into destination vectors used in plants. We demonstrated the feasibility and flexibility of the technology by developing a set of modular vectors for genome editing. After construction and validation, the TALEN pairs were used to create stable transgenic rice lines via Agrobacterium-mediated transformation. One heterozygous mutant (4%) was recovered from 25 transgenic NPTII-resistant lines, and the mutation was transmitted to the next generation. Further molecular and protein level experiments verified LOX3 deficiency and demonstrated the improvement of seed storability. Our work provides a flexible genome editing tool for improving important agronomic traits, as well as direct evidence that Lox3 has only a limited impact on seed longevity.

TALEN-Based Mutagenesis of Lipoxygenase LOX3 Enhances the Storage Tolerance of Rice (Oryza sativa Seeds.

Directory of Open Access Journals (Sweden)

Lei Ma

Full Text Available The deterioration of rice grain reduces the quality of rice, resulting in serious economic losses for farmers. Lipoxygenases (LOXs catalyze the dioxygenation of polyunsaturated fatty acids with at least one cis,cis-1,4-pentadiene to form hydroperoxide, which is a major factor influencing seed longevity and viability. Recently, genome editing, an essential tool employed in reverse genetics, has been used experimentally to investigate basic plant biology or to modify crop plants for the improvement of important agricultural traits. In this study, we performed targeted mutagenesis in rice using transcription activator-like effector nucleases (TALENs to improve seed storability. A modified ligation-independent cloning method (LIC was employed to allow for the quick and efficient directional insertion of TALEN monomer modules into destination vectors used in plants. We demonstrated the feasibility and flexibility of the technology by developing a set of modular vectors for genome editing. After construction and validation, the TALEN pairs were used to create stable transgenic rice lines via Agrobacterium-mediated transformation. One heterozygous mutant (4% was recovered from 25 transgenic NPTII-resistant lines, and the mutation was transmitted to the next generation. Further molecular and protein level experiments verified LOX3 deficiency and demonstrated the improvement of seed storability. Our work provides a flexible genome editing tool for improving important agronomic traits, as well as direct evidence that Lox3 has only a limited impact on seed longevity.

Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.

Science.gov (United States)

Betz, U A; Vosshenrich, C A; Rajewsky, K; Müller, W

1996-10-01

The analysis of gene function based on the generation of mutant mice by homologous recombination in embryonic stem cells is limited if gene disruption results in embryonic lethality. Mosaic mice, which contain a certain proportion of mutant cells in all organs, allow lethality to be circumvented and the potential of mutant cells to contribute to different cell lineages to be analyzed. To generate mosaic animals, we used the bacteriophage P1-derived Cre-loxP recombination system, which allows gene alteration by Cre-mediated deletion of loxP-flanked gene segments. We generated nestin-cre transgenic mouse lines, which expressed the Cre recombinase under the control of the rat nestin promoter and its second intron enhancer. In crosses to animals carrying a loxP-flanked target gene, partial deletion of the loxP-flanked allele occurred before day 10.5 post coitum and was detectable in all adult organs examined, including germ-line cells. Using this approach, we generated mosaic mice containing cells deficient in the gamma-chain of the interleukin-2 receptor (IL-2R gamma); in these animals, the IL-2R gamma-deficient cells were underrepresented in the thymus and spleen. Because mice deficient in DNA polymerase beta die perinatally, we studied the effects of DNA polymerase beta deficiency in mosaic animals. We found that some of the mosaic polymerase beta-deficient animals were viable, but were often reduced in size and weight. The fraction of DNA polymerase beta-deficient cells in mosaic embryos decreased during embryonic development, presumably because wild-type cells had a competitive advantage. The nestin-cre transgenic mice can be used to generate mosaic animals in which target genes are mutated by Cre-mediated recombination of loxP-flanked target genes. By using mosaic animals, embryonic lethality can be bypassed and cell lineages for whose development a given target gene is critical can be identified. In the case of DNA polymerase beta, deficient cells are already

Activated human mast cells induce LOX-1-specific scavenger receptor expression in human monocyte-derived macrophages.

Directory of Open Access Journals (Sweden)

Mervi Alanne-Kinnunen

Full Text Available Activated mast cells in atherosclerotic lesions degranulate and release bioactive compounds capable of regulating atherogenesis. Here we examined the ability of activated human primary mast cells to regulate the expression of the major scavenger receptors in cultured human primary monocyte-derived macrophages (HMDMs.Components released by immunologically activated human primary mast cells induced a transient expression of lectin-like oxidized LDL receptor (LOX-1 mRNA in HMDMs, while the expression of two other scavenger receptors, MSR1 and CD36, remained unaffected. The LOX-1-inducing secretory components were identified as histamine, tumor necrosis factor alpha (TNF-α, and transforming growth factor beta (TGF-β1, which exhibited a synergistic effect on LOX-1 mRNA expression. Histamine induced a transient expression of LOX-1 protein. Mast cell -induced increase in LOX-1 expression was not associated with increased uptake of oxidized LDL by the macrophages.Mast cell-derived histamine, TNF-α, and TGF-β1 act in concert to induce a transient increase in LOX-1 expression in human primary monocyte-derived macrophages. The LOX-1-inducing activity potentially endows mast cells a hitherto unrecognized role in the regulation of innate immune reactions in atherogenesis.

Airbreathing engine selection criteria for SSTO propulsion system

Science.gov (United States)

Ohkami, Yoshiaki; Maita, Masataka

1995-02-01

This paper presents airbreathing engine selection criteria to be applied to the propulsion system of a Single Stage To Orbit (SSTO). To establish the criteria, a relation among three major parameters, i.e., delta-V capability, weight penalty, and effective specific impulse of the engine subsystem, is derived as compared to these parameters of the LH2/LOX rocket engine. The effective specific impulse is a function of the engine I(sub sp) and vehicle thrust-to-drag ratio which is approximated by a function of the vehicle velocity. The weight penalty includes the engine dry weight, cooling subsystem weight. The delta-V capability is defined by the velocity region starting from the minimum operating velocity up to the maximum velocity. The vehicle feasibility is investigated in terms of the structural and propellant weights, which requires an iteration process adjusting the system parameters. The system parameters are computed by iteration based on the Newton-Raphson method. It has been concluded that performance in the higher velocity region is extremely important so that the airbreathing engines are required to operate beyond the velocity equivalent to the rocket engine exhaust velocity (approximately 4500 m/s).

'Bimodal' NTR and LANTR propulsion for human missions to Mars/Phobos

International Nuclear Information System (INIS)

Borowski, Stanley K.; Dudzinski, Leonard A.; McGuire, Melissa L.

1999-01-01

The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human missions to Mars due to its high specific impulse (Isp ∼850-1000 s) and attractive engine thrust-to-weight ratio (∼3-10). Because only a miniscule amount of enriched uranium-235 fuel is consumed in a NTR during the primary propulsion maneuvers of a typical Mars mission, engines configured for both propulsive thrust and modest power generation (referred to as 'bimodal' operation) provide the basis for a robust, 'power-rich' stage enabling propulsive Mars capture and reuse capability. A family of modular 'bimodal' NTR (BNTR) vehicles are described which utilize a common 'core' stage powered by three 66.7 kN (∼15 klbf) BNTRs that produce 50 kWe of total electrical power for crew life support, an active refrigeration/reliquification system for long term, 'zero-boiloff' liquid hydrogen (LH 2 ) storage, and high data rate communications. Compared to other propulsion options, a Mars mission architecture using BNTR transfer vehicles requires fewer transportation system elements which reduces mission mass, cost and risk because of simplified space operations. For difficult Mars options, such as a Phobos rendezvous and sample return mission, volume (not mass) constraints limit the performance of the 'all LH 2 ' BNTR stage. The use of ''LOX-augmented' NTR (LANTR) engines, operating at a modest oxygen-to-hydrogen (O/H) mixture ratio (MR) of 0.5, helps to increase 'bulk' propellant density and total thrust during the trans-Mars injection (TMI) burn. On all subsequent burns, the bimodal LANTR engines operate on LH 2 only (MR=0) to maximize vehicle performance while staying within the mass limits of two ∼80 t 'Magnum' heavy lift launch vehicles (HLLVs)

Mesoscopic model of actin-based propulsion.

Directory of Open Access Journals (Sweden)

Jie Zhu

Full Text Available Two theoretical models dominate current understanding of actin-based propulsion: microscopic polymerization ratchet model predicts that growing and writhing actin filaments generate forces and movements, while macroscopic elastic propulsion model suggests that deformation and stress of growing actin gel are responsible for the propulsion. We examine both experimentally and computationally the 2D movement of ellipsoidal beads propelled by actin tails and show that neither of the two models can explain the observed bistability of the orientation of the beads. To explain the data, we develop a 2D hybrid mesoscopic model by reconciling these two models such that individual actin filaments undergoing nucleation, elongation, attachment, detachment and capping are embedded into the boundary of a node-spring viscoelastic network representing the macroscopic actin gel. Stochastic simulations of this 'in silico' actin network show that the combined effects of the macroscopic elastic deformation and microscopic ratchets can explain the observed bistable orientation of the actin-propelled ellipsoidal beads. To test the theory further, we analyze observed distribution of the curvatures of the trajectories and show that the hybrid model's predictions fit the data. Finally, we demonstrate that the model can explain both concave-up and concave-down force-velocity relations for growing actin networks depending on the characteristic time scale and network recoil. To summarize, we propose that both microscopic polymerization ratchets and macroscopic stresses of the deformable actin network are responsible for the force and movement generation.

Magnetohydrodynamic Augmented Propulsion Experiment

Science.gov (United States)

Litchford, Ron J.; Cole, John; Lineberry, John; Chapman, Jim; Schmidt, Harold; Cook, Stephen (Technical Monitor)

2002-01-01

A fundamental obstacle to routine space access is the specific energy limitations associated with chemical fuels. In the case of vertical take-off, the high thrust needed for vertical liftoff and acceleration to orbit translates into power levels in the 10 GW range. Furthermore, useful payload mass fractions are possible only if the exhaust particle energy (i.e., exhaust velocity) is much greater than that available with traditional chemical propulsion. The electronic binding energy released by the best chemical reactions (e.g., LOX/LH2 for example, is less than 2 eV per product molecule (approx. 1.8 eV per H2O molecule), which translates into particle velocities less than 5 km/s. Useful payload fractions, however, will require exhaust velocities exceeding 15 km/s (i.e., particle energies greater than 20 eV). As an added challenge, the envisioned hypothetical RLV (reusable launch vehicle) should accomplish these amazing performance feats while providing relatively low acceleration levels to orbit (2-3g maximum). From such fundamental considerations, it is painfully obvious that planned and current RLV solutions based on chemical fuels alone represent only a temporary solution and can only result in minor gains, at best. What is truly needed is a revolutionary approach that will dramatically reduce the amount of fuel and size of the launch vehicle. This implies the need for new compact high-power energy sources as well as advanced accelerator technologies for increasing engine exhaust velocity. Electromagnetic acceleration techniques are of immense interest since they can be used to circumvent the thermal limits associated with conventional propulsion systems. This paper describes the Magnetohydrodynamic Augmented Propulsion Experiment (MAPX) being undertaken at NASA Marshall Space Flight Center (MSFC). In this experiment, a 1-MW arc heater is being used as a feeder for a 1-MW magnetohydrodynamic (MHD) accelerator. The purpose of the experiment is to demonstrate

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.

Science.gov (United States)

Gregus, Ann M; Dumlao, Darren S; Wei, Spencer C; Norris, Paul C; Catella, Laura C; Meyerstein, Flore G; Buczynski, Matthew W; Steinauer, Joanne J; Fitzsimmons, Bethany L; Yaksh, Tony L; Dennis, Edward A

2013-05-01

Previously, we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilins, which contribute to peripheral inflammation-induced tactile allodynia. However, the enzymatic sources of hepoxilin synthase (HXS) activity in rats remain elusive. Therefore, we overexpressed each of the 6 rat 12/15-LOX enzymes in HEK-293T cells and measured by LC-MS/MS the formation of HXB3, 12-HETE, 8-HETE, and 15-HETE from arachidonic acid (AA) at baseline and in the presence of LOX inhibitors (NDGA, AA-861, CDC, baicalein, and PD146176) vs. vehicle-treated and mock-transfected controls. We detected the following primary intrinsic activities: 12-LOX (Alox12, Alox15), 15-LOX (Alox15b), and HXS (Alox12, Alox15). Similar to human and mouse orthologs, proteins encoded by rat Alox12b and Alox12e possessed minimal 12-LOX activity with AA as substrate, while eLOX3 (encoded by Aloxe3) exhibited HXS without 12-LOX activity when coexpressed with Alox12b or supplemented with 12-HpETE. CDC potently inhibited HXS and 12-LOX activity in vitro (relative IC50s: CDC, ~0.5 and 0.8 μM, respectively) and carrageenan-evoked tactile allodynia in vivo. Notably, peripheral inflammation significantly increased spinal eLOX3; intrathecal pretreatment with either siRNA targeting Aloxe3 or an eLOX3-selective antibody attenuated the associated allodynia. These findings implicate spinal eLOX3-mediated hepoxilin synthesis in inflammatory hyperesthesia and underscore the importance of developing more selective 12-LOX/HXS inhibitors.

Fin Ray Stiffness and Fin Morphology Control Ribbon-Fin-Based Propulsion.

Science.gov (United States)

Liu, Hanlin; Taylor, Bevan; Curet, Oscar M

2017-06-01

Ribbon-fin-based propulsion has rich locomotor capabilities that can enhance the mobility and performance of underwater vehicles navigating in complex environments. Bony fishes using this type of propulsion send one or multiple traveling waves along an elongated fin with the actuation of highly flexible rays that are interconnected by an elastic membrane. In this work, we study how the use of flexible rays and different morphology can affect the performance of ribbon-fin propulsion. We developed a physical model composed of 15 rays that are interconnected with an elastic membrane. We tested four different ray flexural stiffness and four aspect ratios. The robotic model was tested in a low-turbulence flume under two flow conditions ([Formula: see text] wavelength/s). In two experimental sets, we measured fin kinematics, net surge forces, and power consumption. Using these data, we perform a thrust and power analysis of the undulating fin. We present the thrust coefficient, power coefficient, and propulsive efficiency. We find that the thrust generation was linear with the enclosed area swept by the fin, and square of the relative velocity between the incoming flow and traveling wave. The thrust coefficient levels off around 0.5. In addition, for our parameter range, we find that the power consumption scales by the cube of the effective tangential velocity of the rays [Formula: see text] (A is the amplitude of the ray oscillating motion, and [Formula: see text] is the angular velocity). We show that a decay in stiffness decreases both thrust production and power consumption. However, for rays with high flexural stiffness, the difference in thrust compared with rigid rays is minimal. Moreover, our results show that flexible rays can improve the propulsive efficiency compared with a rigid counterpart. Finally, we find that the morphology of ribbon fin affects its propulsive efficiency. For the aspect ratio considered in our experiments, [Formula: see text] was the most

Combustion chamber heat transfer characterization of LOX/hydrocarbon-type propellants

Science.gov (United States)

Schoenman, Leonard

1987-01-01

The gas-side heat transfer rates for LOX/propane and LOX/ethanol are experimentally characterized using a 1000 lb thrust water-cooled calorimeter chamber. The effects of injector element type and fuel film cooling are defined as a function of mixture ratio. The interaction of fuel injected through the resonator cavities on heat transfer and wall soot buildup are displayed as a function of time, axial distance, fuel coolant flow rate, and mixture ratio. Comparisons between clean-burning ethanol and sooting propane show a large difference between the two fuels and significantly higher than expected heat flux levels for ethanol in the throat region.

Human exploration and settlement of the Moon using LUNOX-augmented NTR propulsion

Science.gov (United States)

Borowski, Stanley K.; Culver, Donald W.; Bulman, Melvin J.

1995-10-01

An innovative trimodal nuclear thermal rocket (NTR) concept is described which combines conventional liquid hydrogen (LH2)-cooled NTR, Brayton cycle power generation and supersonic combustion ramjet (scramjet) technologies. Known as the liquid oxygen (LOX) augmented NTR (LANTR), this concept utilizes the large divergent section of the NTR nozzle as an 'afterburner' into which LOX is injected and supersonically combusted with nuclear preheated hydrogen emerging from the LANTR's choked sonic throat--'scramjet propulsion in reverse.' By varying the oxygen-to-hydrogen mixture ratio (MR), the LANTR can operate over a wide range of thrust and specific impulse (Isp) values while the reactor core power level remains relatively constant. As the MR varies from zero to seven, the thrust-to-weight ratio for a 15 thousand pound force (klbf) NTR increases by approximately 440%--from 3 to 13--while the Isp decreases by only approximately 45%--from 940 to 515 seconds. This thrust augmentation feature of the LANTR means that 'big engine' performance can be obtained using smaller more affordable, easier to test NTR engines. 'Reoxidizing' the bipropellant LANTR system in low lunar orbit (LLO) with high density 'lunar-derived' LOX (LUNOX) enables a reusable, reduced size and mass lunar transfer vehicle (LTV) which can be deployed and resupplied using two 66 t-class Shuttle-derived launch vehicles. The reusable LANTR can also transport 200 to 300% more payload on each piloted round trip mission than an expendable 'all LH2' NTR system. As initial outposts grow to eventual lunar settlements and LUNOX production capacity increases, the LANTR concept can also enable a rapid 'commuter' shuttle capable of 36 to 24 hour 'one way' trips to the Moon and back with reasonable size vehicles and initial mass in low Earth orbit (IMLEO) requirements.

Involvement of PLA2, COX and LOX in Rhinella arenarum oocyte maturation.

Science.gov (United States)

Ortiz, Maria Eugenia; Bühler, Marta Inés; Zelarayán, Liliana Isabel

2014-11-01

In Rhinella arenarum, progesterone is the physiological nuclear maturation inducer that interacts with the oocyte surface and starts a cascade of events that leads to germinal vesicle breakdown (GVBD). Polyunsaturated fatty acids and their metabolites produced through cyclooxygenase (COX) and lipoxygenase (LOX) pathways play an important role in reproductive processes. In amphibians, to date, the role of arachidonic acid (AA) metabolites in progesterone (P4)-induced oocyte maturation has not been clarified. In this work we studied the participation of three enzymes involved in AA metabolism - phospholipase A2 (PLA2), COX and LOX in Rhinella arenarum oocyte maturation. PLA2 activation induced maturation in Rhinella arenarum oocytes in a dose-dependent manner. Oocytes when treated with 0.08 μM melittin showed the highest response (78 ± 6% GVBD). In follicles, PLA2 activation did not significantly induce maturation at the assayed doses (12 ± 3% GVBD). PLA2 inhibition with quinacrine prevented melittin-induced GVBD in a dose-dependent manner, however PLA2 inactivation did not affect P4-induced maturation. This finding suggests that PLA2 is not the only phospholipase involved in P4-induced maturation in this species. P4-induced oocyte maturation was inhibited by the COX inhibitors indomethacin and rofecoxib (65 ± 3% and 63 ± 3% GVBD, respectively), although COX activity was never blocked by their addition. Follicles showed a similar response following the addition of these inhibitors. Participation of LOX metabolites in maturation seems to be correlated with seasonal variation in ovarian response to P4. During the February to June period (low P4 response), LOX inhibition by nordihydroguaiaretic acid or lysine clonixinate increased maturation by up to 70%. In contrast, during the July to January period (high P4 response), LOX inhibition had no effect on hormone-induced maturation.

Cloning-free genome engineering in Sinorhizobium meliloti advances applications of Cre/loxP site-specific recombination.

Science.gov (United States)

Döhlemann, Johannes; Brennecke, Meike; Becker, Anke

2016-09-10

The soil-dwelling α-proteobacterium Sinorhizobium meliloti serves as model for studies of symbiotic nitrogen fixation, a highly important process in sustainable agriculture. Here, we report advancements of the genetic toolbox accelerating genome editing in S. meliloti. The hsdMSR operon encodes a type-I restriction-modification (R-M) system. Transformation of S. meliloti is counteracted by the restriction endonuclease HsdR degrading DNA which lacks the appropriate methylation pattern. We provide a stable S. meliloti hsdR deletion mutant showing enhanced transformation with Escherichia coli-derived plasmid DNA and demonstrate that using an E. coli plasmid donor, expressing S. meliloti methyl transferase genes, is an alternative strategy of increasing the transformation efficiency of S. meliloti. Furthermore, we devise a novel cloning-free genome editing (CFGE) method for S. meliloti, Agrobacterium tumefaciens and Xanthomonas campestris, and demonstrate the applicability of this method for intricate applications of the Cre/lox recombination system in S. meliloti. An enhanced Cre/lox system, allowing for serial deletions of large genomic regions, was established. An assay of lox spacer mutants identified a set of lox sites mediating specific recombination. The availability of several non-promiscuous Cre recognition sites enables simultaneous specific Cre/lox recombination events. CFGE combined with Cre/lox recombination is put forward as powerful approach for targeted genome editing, involving serial steps of manipulation to expedite the genetic accessibility of S. meliloti as chassis. Copyright © 2016 Elsevier B.V. All rights reserved.

Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.

Directory of Open Access Journals (Sweden)

Yaíma L Lightfoot

Full Text Available Mitochondria are indispensable in the life and death of many types of eukaryotic cells. In pancreatic beta cells, mitochondria play an essential role in the secretion of insulin, a hormone that regulates blood glucose levels. Unregulated blood glucose is a hallmark symptom of diabetes. The onset of Type 1 diabetes is preceded by autoimmune-mediated destruction of beta cells. However, the exact role of mitochondria has not been assessed in beta cell death. In this study, we examine the role of mitochondria in both Fas- and proinflammatory cytokine-mediated destruction of the human beta cell line, βLox5. IFNγ primed βLox5 cells for apoptosis by elevating cell surface Fas. Consequently, βLox5 cells were killed by caspase-dependent apoptosis by agonistic activation of Fas, but only after priming with IFNγ. This beta cell line undergoes both apoptotic and necrotic cell death after incubation with the combination of the proinflammatory cytokines IFNγ and TNFα. Additionally, both caspase-dependent and -independent mechanisms that require proper mitochondrial function are involved. Mitochondrial contributions to βLox5 cell death were analyzed using mitochondrial DNA (mtDNA depleted βLox5 cells, or βLox5 ρ(0 cells. βLox5 ρ(0 cells are not sensitive to IFNγ and TNFα killing, indicating a direct role for the mitochondria in cytokine-induced cell death of the parental cell line. However, βLox5 ρ(0 cells are susceptible to Fas killing, implicating caspase-dependent extrinsic apoptotic death is the mechanism by which these human beta cells die after Fas ligation. These data support the hypothesis that immune mediators kill βLox5 cells by both mitochondrial-dependent intrinsic and caspase-dependent extrinsic pathways.

Viral Cre-LoxP tools aid genome engineering in mammalian cells.

Science.gov (United States)

Sengupta, Ranjita; Mendenhall, Amy; Sarkar, Nandita; Mukherjee, Chandreyee; Afshari, Amirali; Huang, Joseph; Lu, Biao

2017-01-01

Targeted nucleases have transformed genome editing technology, providing more efficient methods to make targeted changes in mammalian genome. In parallel, there is an increasing demand of Cre-LoxP technology for complex genome manipulation such as large deletion, addition, gene fusion and conditional removal of gene sequences at the target site. However, an efficient and easy-to-use Cre-recombinase delivery system remains lacking. We designed and constructed two sets of expression vectors for Cre-recombinase using two highly efficient viral systems, the integrative lentivirus and non-integrative adeno associated virus. We demonstrate the effectiveness of those methods in Cre-delivery into stably-engineered HEK293 cells harboring LoxP-floxed red fluorescent protein (RFP) and puromycin (Puro) resistant reporters. The delivered Cre recombinase effectively excised the floxed RFP-Puro either directly or conditionally, therefore validating the function of these molecular tools. Given the convenient options of two selections markers, these viral-based systems offer a robust and easy-to-use tool for advanced genome editing, expanding complicated genome engineering to a variety of cell types and conditions. We have developed and functionally validated two viral-based Cre-recombinase delivery systems for efficient genome manipulation in various mammalian cells. The ease of gene delivery with the built-in reporters and inducible element enables live cell monitoring, drug selection and temporal knockout, broadening applications of genome editing.

A Review of Propulsion Industrial Base Studies and an Introduction to the National Institute of Rocket Propulsion Systems

Science.gov (United States)

Doreswamy, Rajiv; Fry, Emma K.

2012-01-01

Over the past decade there have been over 40 studies that have examined the state of the industrial base and infrastructure that supports propulsion systems development in the United States. This paper offers a comprehensive, systematic review of these studies and develops conclusions and recommendations in the areas of budget, policy, sustainment, infrastructure, workforce retention and development and mission/vision and policy. The National Institute for Rocket Propulsion System (NIRPS) is a coordinated, national organization that is responding to the key issues highlighted in these studies. The paper outlines the case for NIRPS and the specific actions that the Institute is taking to address these issues.

The rationale for targeting the LOX family in cancer

DEFF Research Database (Denmark)

Barker, Holly E; Cox, Thomas R; Erler, Janine T

2012-01-01

The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the ......The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours...... and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in tumorigenesis and metastasis. We also discuss how targeting this family of proteins might lead to a new...... avenue of cancer therapeutics....

Summary of LOX/CH4 Thruster Technology Development at NASA/MSFC

Science.gov (United States)

Greene, Sandra Elam

2015-01-01

In recent years, a variety of injectors for liquid oxygen (LOX) and methane (CH4) propellant systems have been designed, fabricated, and demonstrated with hot-fire testing at Marshall Space Flight Center (MSFC). Successful designs for liquid methane (LCH4) and gaseous methane (GCH4) have been developed. A variety of chambers, including a transpiration cooled design, along with uncooled ablatives and refractory metals, have also been hot-fire tested by MSFC for use with LOX/LCH4 injectors. Hot-fire testing has also demonstrated multiple ignition source options. Heat flux data for selected injectors has been gathered by testing with a calorimeter chamber. High performance and stable combustion have been demonstrated, along with designs for thrust levels ranging from 500 to 7,000 lbf. The newest LOX/CH4 injector and chamber developed by MSFC have been fabricated with additive manufacturing techniques and include unique design features to investigate regenerative cooling with methane. This low cost and versatile hardware offers a design for 4,000 lbf thrust and will be hot-fire tested at MSFC in 2015. Its design and operation can easily be scaled for use in systems with thrust levels up to 25,000 lbf.

A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice.

Directory of Open Access Journals (Sweden)

Linghua Qiu

Full Text Available Transgenes flanked by loxP sites have been widely used to generate transgenic mice where the transgene expression can be controlled spatially and temporally by Cre recombinase. Data from this approach has led to important conclusions in cancer, neurodevelopment and neurodegeneration. Using this approach to conditionally express micro RNAs (miRNAs in mice, we found that Cre-mediated recombination in neural progenitor cells caused microcephaly in five of our ten independent transgenic lines. This effect was not associated with the types or the quantity of miRNAs being expressed, nor was it associated with specific target knockdown. Rather, it was correlated with the presence of multiple tandem transgene copies and inverted (head-to-head or tail-to-tail transgene repeats. The presence of these inverted repeats caused a high level of cell death in the ventricular zone of the embryonic brain, where Cre was expressed. Therefore, results from this Cre-loxP approach to generate inducible transgenic alleles must be interpreted with caution and conclusions drawn in previous reports may need reexamination.

Northrop Grumman TR202 LOX/LH2 Deep Throttling Engine Project Status

Science.gov (United States)

Gromski, J.; Majamaki, A. N.; Chianese, S. G.; Weinstock, V. D.; Kim, T.

2010-01-01

NASA's Propulsion and Cryogenic Advanced Development (PCAD) project is currently developing enabling propulsion technologies in support of the Exploration Initiative, with a particular focus on the needs of the Altair Project. To meet Altair requirements, several technical challenges need to be overcome, one of which is the ability for the lunar descent engine(s) to operate over a deep throttle range with cryogenic propellants. To address this need, PCAD has enlisted Northrop Grumman Aerospace Systems (NGAS) in a technology development effort associated with the TR202, a LOX/LH2 expander cycle engine driven by independent turbopump assemblies and featuring a variable area pintle injector similar to the injector used on the TR200 Apollo Lunar Module Descent Engine (LMDE). Since the Apollo missions, NGAS has continued to mature deep throttling pintle injector technology. The TR202 program has completed two phases of pintle injector testing. The first phase of testing used ablative thrust chambers and demonstrated igniter operation as well as stable performance at several power levels across the designed 10:1 throttle range. The second phase of testing was performed on a calorimeter chamber and demonstrated injector performance at various power levels (75%, 50%, 25%, 10%, and 7.5%) across the throttle range as well as chamber heat flux to show that the engine can close an expander cycle design across the throttle range. This paper provides an overview of the TR202 program. It describes the different phases of the program with the key milestones of each phase. It then shows when those milestones were met. Next, it describes how the test data was used to update the conceptual design and how the test data has created a database for deep throttling cryogenic pintle technology that is readily scaleable and can be used to again update the design once the Altair program's requirements are firm. The final section of the paper describes the path forward, which includes

Isolation and characterization of wild-type lipoxygenase LOX(Psa)1 from Pleurotus sapidus.

Science.gov (United States)

Plagemann, Ina; Krings, Ulrich; Berger, Ralf G

2014-01-01

The lipoxygenase LOX(Psa) 1 of Pleurotus sapidus, originally investigated because of its ability to oxidize (+)-valencene to the valuable grapefruit aroma (+)-nootkatone, was isolated from the peptidase-rich lyophilisate using a three-step purification scheme including preparative isoelectric focusing and chromatographic techniques. Nano-liquid chromatography electrospray ionization tandem mass spectrometry (nLC-ESI-MS/MS) of the purified enzyme and peptide mass fingerprint analysis gave 38 peptides of the lipoxygenase from P. sapidus. Nearly 50% of the 643 amino acids long sequence encoded by the cDNA was covered. Both terminal peptides of the native LOX(Psa) 1 were identified by de novo sequencing, and the postulated molecular mass of 72.5 kDa was confirmed. With linoleic acid as the substrate, the LOX(Psa)1 showed a specific activity of 113 U mg(-1) and maximal activity at pH 7.0 and 30 degrees C, respectively.

Laser Propulsion - Quo Vadis

International Nuclear Information System (INIS)

Bohn, Willy L.

2008-01-01

First, an introductory overview of the different types of laser propulsion techniques will be given and illustrated by some historical examples. Second, laser devices available for basic experiments will be reviewed ranging from low power lasers sources to inertial confinement laser facilities. Subsequently, a status of work will show the impasse in which the laser propulsion community is currently engaged. Revisiting the basic relations leads to new avenues in ablative and direct laser propulsion for ground based and space based applications. Hereby, special attention will be devoted to the impact of emerging ultra-short pulse lasers on the coupling coefficient and specific impulse. In particular, laser sources and laser propulsion techniques will be tested in microgravity environment. A novel approach to debris removal will be discussed with respect to the Satellite Laser Ranging (SRL) facilities. Finally, some non technical issues will be raised aimed at the future prospects of laser propulsion in the international community

Ox-LDL increases OX40L in endothelial cells through a LOX-1-dependent mechanism

Energy Technology Data Exchange (ETDEWEB)

Dong, Q.; Xiang, R.; Zhang, D.Y.; Qin, S. [Department of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing (China)

2013-09-19

Oxidative low-density lipoprotein (Ox-LDL) is a key risk factor for the development of atherosclerosis, and it can stimulate the expression of a variety of inflammatory signals. As a new and highly sensitive inflammation index, OX40L may be a key to understanding the mechanisms that regulate interactions between cells within the vessel wall and inflammatory mediators during the development of atherosclerosis. To investigate whether Ox-LDL regulates OX40L expression through an oxidized LDL-1 receptor (LOX-1)-mediated mechanism, we investigated the effect of different concentrations of Ox-LDL (50, 100, 150 µg/mL) on endothelial cell proliferation and apoptosis. Stimulation with Ox-LDL increased OX40L protein 1.44-fold and mRNA 4.0-fold in endothelial cells, and these effects were inhibited by blocking LOX-1. These results indicate that LOX-1 plays an important role in the chronic inflammatory process in blood vessel walls. Inhibiting LOX-1 may reduce blood vessel inflammation and provide a therapeutic option to limit atherosclerosis progression.

Prokaryotic Expression, Purification and Characterization of a Novel Rice Seed Lipoxygenase Gene OsLOX1

Directory of Open Access Journals (Sweden)

Ren Wang

2008-06-01

Full Text Available Lipoxygenase (LOX, EC1.13.11.12 is a key enzyme during the degradation of lipids in animals and even plants, and also the first key enzyme responsible for the biosynthesis of jasmonate. To purify and characterize the OsLOX1 gene from rice seeds, the entire coding region of the OsLOX1 gene was inserted into an expression vector pET30a(+ and transformed into Escherichia coli BL21 (DE3. Expression of the fusion protein was successfully induced by isopropyl-β-D- thiogalactopyranoside (IPTG and the purified recombinant protein was obtained by His·Bind® Kits. Further assay showed that the purified recombinant protein exhibited the LOX activity. The optimum pH was 4.8 (acetate buffer and the optimum temperature was 30°C for the above enzyme. Thus, the recombinant might confer an available usage for the synthesis of jasmonate in vitro, and also provides a possibility for elucidating the inter-relationship between the primary structure of the plant seed lipoxygenase protein and its physiological functions.

Ox-LDL increases OX40L in endothelial cells through a LOX-1-dependent mechanism

International Nuclear Information System (INIS)

Dong, Q.; Xiang, R.; Zhang, D.Y.; Qin, S.

2013-01-01

Oxidative low-density lipoprotein (Ox-LDL) is a key risk factor for the development of atherosclerosis, and it can stimulate the expression of a variety of inflammatory signals. As a new and highly sensitive inflammation index, OX40L may be a key to understanding the mechanisms that regulate interactions between cells within the vessel wall and inflammatory mediators during the development of atherosclerosis. To investigate whether Ox-LDL regulates OX40L expression through an oxidized LDL-1 receptor (LOX-1)-mediated mechanism, we investigated the effect of different concentrations of Ox-LDL (50, 100, 150 µg/mL) on endothelial cell proliferation and apoptosis. Stimulation with Ox-LDL increased OX40L protein 1.44-fold and mRNA 4.0-fold in endothelial cells, and these effects were inhibited by blocking LOX-1. These results indicate that LOX-1 plays an important role in the chronic inflammatory process in blood vessel walls. Inhibiting LOX-1 may reduce blood vessel inflammation and provide a therapeutic option to limit atherosclerosis progression

The Ion Propulsion System for the Solar Electric Propulsion Technology Demonstration Mission

Science.gov (United States)

Herman, Daniel A.; Santiago, Walter; Kamhawi, Hani; Polk, James E.; Snyder, John Steven; Hofer, Richard R.; Parker, J. Morgan

2015-01-01

The Asteroid Redirect Robotic Mission is a candidate Solar Electric Propulsion Technology Demonstration Mission whose main objectives are to develop and demonstrate a high-power solar electric propulsion capability for the Agency and return an asteroidal mass for rendezvous and characterization in a companion human-crewed mission. The ion propulsion system must be capable of operating over an 8-year time period and processing up to 10,000 kg of xenon propellant. This high-power solar electric propulsion capability, or an extensible derivative of it, has been identified as a critical part of an affordable, beyond-low-Earth-orbit, manned-exploration architecture. Under the NASA Space Technology Mission Directorate the critical electric propulsion and solar array technologies are being developed. The ion propulsion system being co-developed by the NASA Glenn Research Center and the Jet Propulsion Laboratory for the Asteroid Redirect Vehicle is based on the NASA-developed 12.5 kW Hall Effect Rocket with Magnetic Shielding (HERMeS0 thruster and power processing technologies. This paper presents the conceptual design for the ion propulsion system, the status of the NASA in-house thruster and power processing activity, and an update on flight hardware.

Coordination and propulsion and non-propulsion phases in 100 meter breaststroke swimming.

Science.gov (United States)

Strzała, Marek; Krężałek, Piotr; Kucia-Czyszczoń, Katarzyna; Ostrowski, Andrzej; Stanula, Arkadiusz; Tyka, Anna K; Sagalara, Andrzej

2014-01-01

The main purpose of this study was to analyze the coordination, propulsion and non-propulsion phases in the 100 meter breaststroke race. Twenty-seven male swimmers (15.7 ± 1.98 years old) with the total body length (TBL) of 247.0 ± 10.60 [cm] performed an all-out 100 m breaststroke bout. The bouts were recorded with an underwater camera installed on a portable trolley. The swimming kinematic parameters, stroke rate (SR) and stroke length (SL), as well as the coordination indices based on propulsive or non-propulsive movement phases of the arms and legs were distinguished. Swimming speed (V100surface breast) was associated with SL (R = 0.41, p study were measured using partial correlations with controlled age. SL interplayed negatively with the limbs propulsive phase Overlap indicator (R = -0.46, p propulsion Glide indicator. The propulsion in-sweep (AP3) phase of arms and their non-propulsion partial air recovery (ARair) phase interplayed with V100surface breast (R = 0.51, p < 0.05 and 0.48 p < 0.05) respectively, displaying the importance of proper execution of this phase (AP3) and in reducing the resistance recovery phases in consecutive ones.

Alternative propulsion for automobiles

CERN Document Server

Stan, Cornel

2017-01-01

The book presents – based on the most recent research and development results worldwide - the perspectives of new propulsion concepts such as electric cars with batteries and fuel cells, and furthermore plug in hybrids with conventional and alternative fuels. The propulsion concepts are evaluated based on specific power, torque characteristic, acceleration behaviour, specific fuel consumption and pollutant emissions. The alternative fuels are discussed in terms of availability, production, technical complexity of the storage on board, costs, safety and infrastructure. The book presents summarized data about vehicles with electric and hybrid propulsion. The propulsion of future cars will be marked by diversity – from compact electric city cars and range extender vehicles for suburban and rural areas up to hybrid or plug in SUV´s, Pick up´s and luxury class automobiles.

Chemistry and propulsion; Chimie et propulsions

Energy Technology Data Exchange (ETDEWEB)

Potier, P [Maison de la Chimie, 75 - Paris (France); Davenas, A [societe Nationale des Poudres et des Explosifs - SNPE (France); Berman, M [Air Force Office of Scientific Research, Arlington, VA (United States); and others

2002-07-01

During the colloquium on chemistry and propulsion, held in march 2002, ten papers have been presented. The proceedings are brought in this document: ramjet, scram-jet and Pulse Detonation Engine; researches and applications on energetic materials and propulsion; advances in poly-nitrogen chemistry; evolution of space propulsion; environmental and technological stakes of aeronautic propulsion; ramjet engines and pulse detonation engines, automobiles thermal engines for 2015, high temperature fuel cells for the propulsion domain, the hydrogen and the fuel cells in the future transports. (A.L.B.)

Hand rim wheelchair propulsion training using biomechanical real-time visual feedback based on motor learning theory principles.

Science.gov (United States)

Rice, Ian; Gagnon, Dany; Gallagher, Jere; Boninger, Michael

2010-01-01

As considerable progress has been made in laboratory-based assessment of manual wheelchair propulsion biomechanics, the necessity to translate this knowledge into new clinical tools and treatment programs becomes imperative. The objective of this study was to describe the development of a manual wheelchair propulsion training program aimed to promote the development of an efficient propulsion technique among long-term manual wheelchair users. Motor learning theory principles were applied to the design of biomechanical feedback-based learning software, which allows for random discontinuous real-time visual presentation of key spatiotemporal and kinetic parameters. This software was used to train a long-term wheelchair user on a dynamometer during 3 low-intensity wheelchair propulsion training sessions over a 3-week period. Biomechanical measures were recorded with a SmartWheel during over ground propulsion on a 50-m level tile surface at baseline and 3 months after baseline. Training software was refined and administered to a participant who was able to improve his propulsion technique by increasing contact angle while simultaneously reducing stroke cadence, mean resultant force, peak and mean moment out of plane, and peak rate of rise of force applied to the pushrim after training. The proposed propulsion training protocol may lead to favorable changes in manual wheelchair propulsion technique. These changes could limit or prevent upper limb injuries among manual wheelchair users. In addition, many of the motor learning theory-based techniques examined in this study could be applied to training individuals in various stages of rehabilitation to optimize propulsion early on.

Nuclear electric propulsion: An integral part of NASA's nuclear propulsion project

International Nuclear Information System (INIS)

Stone, J.R.

1992-01-01

NASA has initiated a technology program to establish the readiness of nuclear propulsion technology for the Space Exploration Initiative (SEI). This program was initiated with a very modest effort identified with nuclear thermal propulsion (NTP); however, nuclear electric propulsion (NEP) is also an integral part of this program and builds upon NASA's Base Research and Technology Program in power and electric propulsion as well as the SP-100 space nuclear power program. Although the Synthesis Group On America's SEI has identified NEP only as an option for cargo missions, recent studies conducted by NASA-Lewis show that NEP offers the potential for early manned Mars missions as well. Lower power NEP is also of current interest for outer planetary robotic missions. Current plans are reviewed for the overall nuclear propulsion project, with emphasis on NEP and those elements of NTP program which have synergism with NEP

Liquid Oxygen/Liquid Methane Integrated Power and Propulsion

Science.gov (United States)

Banker, Brian; Ryan, Abigail

2016-01-01

The proposed paper will cover ongoing work at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) on integrated power and propulsion for advanced human exploration. Specifically, it will present findings of the integrated design, testing, and operational challenges of a liquid oxygen / liquid methane (LOx/LCH4) propulsion brassboard and Solid Oxide Fuel Cell (SOFC) system. Human-Mars architectures point to an oxygen-methane economy utilizing common commodities, scavenged from the planetary atmosphere and soil via In-Situ Resource Utilization (ISRU), and common commodities across sub-systems. Due to the enormous mass gear-ratio required for human exploration beyond low-earth orbit, (for every 1 kg of payload landed on Mars, 226 kg will be required on Earth) increasing commonality between spacecraft subsystems such as power and propulsion can result in tremendous launch mass and volume savings. Historically, propulsion and fuel cell power subsystems have had little interaction outside of the generation (fuel cell) and consumption (propulsion) of electrical power. This was largely due to a mismatch in preferred commodities (hypergolics for propulsion; oxygen & hydrogen for fuel cells). Although this stove-piped approach benefits from simplicity in the design process, it means each subsystem has its own tanks, pressurization system, fluid feed system, etc. increasing overall spacecraft mass and volume. A liquid oxygen / liquid methane commodities architecture across propulsion and power subsystems would enable the use of common tankage and associated pressurization and commodity delivery hardware for both. Furthermore, a spacecraft utilizing integrated power and propulsion could use propellant residuals - propellant which could not be expelled from the tank near depletion due to hydrodynamic considerations caused by large flow demands of a rocket engine - to generate power after all propulsive maneuvers are complete thus utilizing

Distributed Propulsion Vehicles

Science.gov (United States)

Kim, Hyun Dae

2010-01-01

Since the introduction of large jet-powered transport aircraft, the majority of these vehicles have been designed by placing thrust-generating engines either under the wings or on the fuselage to minimize aerodynamic interactions on the vehicle operation. However, advances in computational and experimental tools along with new technologies in materials, structures, and aircraft controls, etc. are enabling a high degree of integration of the airframe and propulsion system in aircraft design. The National Aeronautics and Space Administration (NASA) has been investigating a number of revolutionary distributed propulsion vehicle concepts to increase aircraft performance. The concept of distributed propulsion is to fully integrate a propulsion system within an airframe such that the aircraft takes full synergistic benefits of coupling of airframe aerodynamics and the propulsion thrust stream by distributing thrust using many propulsors on the airframe. Some of the concepts are based on the use of distributed jet flaps, distributed small multiple engines, gas-driven multi-fans, mechanically driven multifans, cross-flow fans, and electric fans driven by turboelectric generators. This paper describes some early concepts of the distributed propulsion vehicles and the current turboelectric distributed propulsion (TeDP) vehicle concepts being studied under the NASA s Subsonic Fixed Wing (SFW) Project to drastically reduce aircraft-related fuel burn, emissions, and noise by the year 2030 to 2035.

Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2.

Science.gov (United States)

Murphy, Jane E; Vohra, Ravinder S; Dunn, Sarah; Holloway, Zoe G; Monaco, Anthony P; Homer-Vanniasinkam, Shervanthi; Walker, John H; Ponnambalam, Sreenivasan

2008-07-01

The LOX-1 scavenger receptor recognises pro-atherogenic oxidised low-density lipoprotein (OxLDL) particles and is implicated in atherosclerotic plaque formation, but this mechanism is not well understood. Here we show evidence for a novel clathrin-independent and cytosolic-signal-dependent pathway that regulates LOX-1-mediated OxLDL internalisation. Cell surface labelling in the absence or presence of OxLDL ligand showed that LOX-1 is constitutively internalised from the plasma membrane and its half-life is not altered upon ligand binding and trafficking. We show that LOX-1-mediated OxLDL uptake is disrupted by overexpression of dominant-negative dynamin-2 but unaffected by CHC17 or mu2 (AP2) depletion. Site-directed mutagenesis revealed a conserved and novel cytoplasmic tripeptide motif (DDL) that regulates LOX-1-mediated endocytosis of OxLDL. Taken together, these findings indicate that LOX-1 is internalised by a clathrin-independent and dynamin-2-dependent pathway and is thus likely to mediate OxLDL trafficking in vascular tissues.

Construction of Marker-Free Transgenic Strains of Chlamydomonas reinhardtii Using a Cre/loxP-Mediated Recombinase System.

Science.gov (United States)

Kasai, Yuki; Harayama, Shigeaki

2016-01-01

The Escherichia coli bacteriophage P1 encodes a site-specific recombinase called Cre and two 34-bp target sites of Cre recombinase called loxP. The Cre/loxP system has been used to achieve targeted insertion and precise deletion in many animal and plant genomes. The Cre/loxP system has particularly been used for the removal of selectable marker genes to create marker-free transgenic organisms. For the first time, we applied the Cre/loxP-mediated site-specific recombination system to Chlamydomonas reinhardtii to construct marker-free transgenic strains. Specifically, C. reinhardtii strains cc4350 and cc124 carrying an aphVIII expression cassette flanked by two direct repeats of loxP were constructed. Separately, a synthetic Cre recombinase gene (CrCRE), the codons of which were optimized for expression in C. reinhardtii, was synthesized, and a CrCRE expression cassette was introduced into strain cc4350 carrying a single copy of the loxP-flanked aphVIII expression cassette. Among 46 transformants carrying the CrCRE expression cassette stably, the excision of aphVIII by CrCre recombinase was observed only in one transformant. We then constructed an expression cassette of an in-frame fusion of ble to CrCRE via a short linker peptide. The product of ble (Ble) is a bleomycin-binding protein that confers resistance to bleomycin-related antibiotics such as Zeocin and localizes in the nucleus. Therefore, the ble-(linker)-CrCRE fusion protein is expected to localize in the nucleus. When the ble-(linker)-CrCRE expression cassette was integrated into the genome of strain cc4350 carrying a single copy of the loxP-flanked aphVIII expression cassette, CrCre recombinase-mediated excision of the aphVIII expression cassette was observed at a frequency higher than that in stable transformants of the CrCRE expression cassette. Similarly, from strain cc124 carrying a single loxP-flanked aphVIII expression cassette, the aphVIII expression cassette was successfully excised after

Size does matter: Cre-mediated somatic deletion efficiency depends on the distance between the target lox-sites

NARCIS (Netherlands)

Coppoolse, E.R.; Vroomen, de M.J.; Gennip, van F.; Hersmus, B.J.M.; Haaren, van M.J.

2005-01-01

Cre/lox recombination in vivo has become an important tool to induce chromosomal rearrangements like deletions. Using a combination of Ds transposition and Cre/lox recombination in two independent experiments on chromosomes 6 and 7 of tomato, two sets of somatic deletions up to a size of 200 kb were

A self-excising Cre recombinase allows efficient recombination of multiple ectopic heterospecific lox sites in transgenic tobacco

NARCIS (Netherlands)

Mlynarova, L.; Nap, J.P.H.

2003-01-01

To study the impact of different DNA configurations on the stability of transgene expression, a variant of the cre gene was developed. This variant allows for the highly efficient in planta removal of its own loxP-flanked coding sequence as well as other DNAs flanked by ectopic heterospecific lox

Liquid oxygen liquid acquisition device bubble point tests with high pressure lox at elevated temperatures

Science.gov (United States)

Jurns, J. M.; Hartwig, J. W.

2012-04-01

When transferring propellant in space, it is most efficient to transfer single phase liquid from a propellant tank to an engine. In earth's gravity field or under acceleration, propellant transfer is fairly simple. However, in low gravity, withdrawing single-phase fluid becomes a challenge. A variety of propellant management devices (PMDs) are used to ensure single-phase flow. One type of PMD, a liquid acquisition device (LAD) takes advantage of capillary flow and surface tension to acquire liquid. The present work reports on testing with liquid oxygen (LOX) at elevated pressures (and thus temperatures) (maximum pressure 1724 kPa and maximum temperature 122 K) as part of NASA's continuing cryogenic LAD development program. These tests evaluate LAD performance for LOX stored in higher pressure vessels that may be used in propellant systems using pressure fed engines. Test data shows a significant drop in LAD bubble point values at higher liquid temperatures, consistent with lower liquid surface tension at those temperatures. Test data also indicates that there are no first order effects of helium solubility in LOX on LAD bubble point prediction. Test results here extend the range of data for LOX fluid conditions, and provide insight into factors affecting predicting LAD bubble point pressures.

Risk Assessment and scaling for the SLS LOx ET

Science.gov (United States)

Osipov, Viatcheslav V.; Hafiychuk, Halyna; Devine, Ekaterina V.; Khasin, Michael; Smelyanskiy, Vadim N.

2012-01-01

In this report we analyze the transpiration cooling by He bubble injection of the long LOx tank feedline heated by the environment heat. We consider possible hazards that can arise in the proposed design of the SLS core stage where the feedline length is much longer than that used in the Space Shuttle.

THE FUTURE OF SPACECRAFT NUCLEAR PROPULSION

OpenAIRE

Jansen, Frank

2014-01-01

This paper summarizes the advantages of space nuclear power and propulsion systems. It describes the actual status of international power level dependent spacecraft nuclear propulsion missions, especially the high power EU-Russian MEGAHIT study including the Russian Megawatt-Class Nuclear Power Propulsion System, the NASA GRC project and the low and medium power EU DiPoP study. Space nuclear propulsion based mission scenarios of these studies are sketched as well.

Nuclear-microwave-electric propulsion

International Nuclear Information System (INIS)

Nordley, G.D.; Brown, W.C.

1986-01-01

Electric propulsion can move more mass through space than chemical propulsion by virtue of the higher exhaust velocities achieved by electric propulsion devices. This performance is achieved at the expense of very heavy power sources or very long trip times, which in turn create technical and economic penalties of varying severity. These penalties include: higher operations costs, delayed availability of the payload, and increased exposure to Van Allen Belt radiation. It is proposed to reduce these penalties by physically separating the power source from the propulsion and use microwave energy beaming technology, recently explored and partially developed/tested for Solar Power Satellite concept studies, as an extension cord. This paper summarizes the state of the art of the technology needed for space based beam microwave power cost/performance trades involved with the use beamed microwave/electric propulsion for some typical orbit transfer missions and offers some suggestions for additional work

Revisiting alpha decay-based near-light-speed particle propulsion

International Nuclear Information System (INIS)

Zhang, Wenwu; Liu, Zhen; Yang, Yang; Du, Shiyu

2016-01-01

Interplanet and interstellar travels require long-term propulsion of spacecrafts, whereas the conventional schemes of propulsion are limited by the velocity of the ejected mass. In this study, alpha particles released by nuclear decay are considered as a potential solution for long-time acceleration. The principle of near-light-speed particle propulsion (NcPP) was elucidated and the stopping and range of ions in matter (SRIM) was used to predict theoretical accelerations. The results show that NcPP by means of alpha decay is feasible for long-term spacecraft propulsion and posture adjustment in space. A practical NcPP sail can achieve a speed >150 km/s and reach the brink of the solar system faster than a mass equivalent solar sail. Finally, to significantly improve the NcPP sail, the hypothesis of stimulated acceleration of nuclear decay (SAND) was proposed, which may shorten the travel time to Mars to within 20 days. - Highlights: • SRIM was used to study the alpha particle penetration depth and efficiency. • Correlation between thickness of decayable foil and propulsion force was established. • With the hypothesis of SAND, the travel time to Mars may be shortened to <20 days.

Simulation of water vapor condensation on LOX droplet surface using liquid nitrogen

Science.gov (United States)

Powell, Eugene A.

1988-01-01

The formation of ice or water layers on liquid oxygen (LOX) droplets in the Space Shuttle Main Engine (SSME) environment was investigated. Formulation of such ice/water layers is indicated by phase-equilibrium considerations under conditions of high partial pressure of water vapor (steam) and low LOX droplet temperature prevailing in the SSME preburner or main chamber. An experimental investigation was begun using liquid nitrogen as a LOX simulant. A monodisperse liquid nitrogen droplet generator was developed which uses an acoustic driver to force the stream of liquid emerging from a capillary tube to break up into a stream of regularly space uniformly sized spherical droplets. The atmospheric pressure liquid nitrogen in the droplet generator reservoir was cooled below its boiling point to prevent two phase flow from occurring in the capillary tube. An existing steam chamber was modified for injection of liquid nitrogen droplets into atmospheric pressure superheated steam. The droplets were imaged using a stroboscopic video system and a laser shadowgraphy system. Several tests were conducted in which liquid nitrogen droplets were injected into the steam chamber. Under conditions of periodic droplet formation, images of 600 micron diameter liquid nitrogen droplets were obtained with the stroboscopic video systems.

α-Fetoprotein promoter-driven Cre/LoxP-switched RNA interference for hepatocellular carcinoma tissue-specific target therapy.

Directory of Open Access Journals (Sweden)

Yuan-Fei Peng

Full Text Available RNA interference (RNAi has recently emerged as a potential treatment modality for hepatocellular carcinoma (HCC therapy, but the lack of cellular targets and sustained efficacy limits its application. The purpose of this study is to develop an HCC tissue-specific RNAi system and investigate its possibility for HCC treatment.Two different HCC-specific RNAi systems in which therapeutic miRNA or shRNA against target gene (Beclin 1 was directly or indirectly driven by alpha-fetoprotein promoter (AFP-miRNA and AFP-Cre/LoxP-shRNA were constructed. Human HCC cell lines (HepG2, Hep3B and HCCLM3 and non-HCC cell lines (L-02, Hela and SW1116 were infected with the systems. The effectiveness and tissue-specificity of the systems were examined by Q-PCR and western blot analysis. The efficacy of the systems was further tested in mouse model of HCC by intravenous or intratumoral administration. The feasibility of the system for HCC treatment was evaluated by applying the system as adjuvant therapy to enhance sorafenib treatment. An AFP-Cre/LoxP-shRNA system targeting Atg5 gene (AFP-Cre/LoxP-shRNA-Atg5 was constructed and its efficacy in sensitizing HCC cells (MHCC97L/PLC to sorafenib treatment was examined by apoptosis assay in vitro and tumorigenesis assay in vivo.The AFP-miRNA system could silence target gene (Beclin 1 but required a high titer which was lethal to target cells. The AFP-Cre/LoxP-shRNA system could efficiently knockdown target gene while maintain high HCC specificity. Intratumoral injection of the AFP-Cre/LoxP-shRNA system could efficiently silence target gene (Beclin 1 in vivo while intravenous administration could not. The AFP-Cre/LoxP-shRNA system target Atg5 gene could significantly sensitize MHCC97L/PLC cells to sorafenib-induced apoptosis in vitro and tumor growth suppression in vivo.An efficient HCC tissue-specific RNAi system (AFP-Cre/LoxP-shRNA was successfully established. The system provides a usable tool for HCC-specific RNAi

The 9-lipoxygenase Osr9-LOX1 interacts with the 13-lipoxygenase-mediated pathway to regulate resistance to chewing and piercing-sucking herbivores in rice.

Science.gov (United States)

Zhou, Guoxin; Ren, Nan; Qi, Jingfeng; Lu, Jing; Xiang, Caiyu; Ju, Hongping; Cheng, Jiaan; Lou, Yonggen

2014-09-01

Oxylipins produced by the 13-lipoxygenase (LOX) have been reported to play an important role in plant defense responses to herbivores. Yet, the role of oxylipins produced by the 9-LOX pathway in this process remains largely unknown. Here we cloned a gene encoding a chloroplast-localized 9-LOX, Osr9-LOX1, from rice. Transcriptional analysis revealed that herbivore infestation, mechanical wounding and jasmonic acid (JA) treatment either repressed or did not enhance the level of Osr9-LOX1 transcripts at early stages but did at later stages, whereas salicylic acid (SA) treatment quickly increased the transcript level of Osr9-LOX1. Antisense expression of Osr9-lox1 (as-r9lox1) decreased the amount of wound-induced (Z)-3-hexenal but increased levels of striped stem borer (SSB)-induced linolenic acid, JA, SA and trypsin protease inhibitors. These changes were associated with increased resistance in rice to the larvae of the SSB Chilo suppressalis. In contrast, although no significant differences were observed in the duration of the nymph stage or the number of eggs laid by female adults between the brown planthopper (BPH) Nilaparvata lugens that fed on as-r9lox1 lines and BPH that fed on wild-type (WT) rice plants, the survival rate of BPH nymphs that fed on as-r9lox1 lines was higher than that of nymphs that fed on WT plants, possibly because of a higher JA level. The results demonstrate that Osr9-LOX1 plays an important role in regulating an herbivore-induced JA burst and cross-talk between JA and SA, and in controlling resistance in rice to chewing and phloem-feeding herbivores. © 2014 Scandinavian Plant Physiology Society.

Operational Issues in the Development of a Cost-Effective Reusable LOX/LH2 Engine

Science.gov (United States)

Ballard, Richard O.

2003-01-01

The NASA Space Launch Initiative (SLI) was initiated in early 2001 to conduct technology development and to reduce the business and technical risk associated with developing the next-generation reusable launch system. In the field of main propulsion, two LOXLH2 rocket engine systems, the Pratt & Whitney / Aerojet Joint Venture (JV) COBRA and the Rocketdyne RS-83, were funded to develop a safe, economical, and reusable propulsion system. Given that a large-thrust reusable rocket engine program had not been started in the U.S. since 1971, with the Space Shuttle Main Engine (SSME), this provided an opportunity to build on the experience developed on the SSME system, while exploiting advances in technology that had occurred in the intervening 30 years. One facet of engine development that was identified as being especially vital in order to produce an optimal system was in the areas of operability and maintainability. In order to achieve the high levels of performance required by the Space Shuttle, the SSME system is highly complex with very tight tolerances and detailed requirements. Over the lifetime of the SSME program, the engine has required a high level of manpower to support the performance of inspections, maintenance (scheduled and unscheduled) and operations (prelaunch and post-flight). As a consequence, the labor- intensive needs of the SSME provide a significant impact to the overall cost efficiency of the Space Transportation System (STS). One of the strategic goals of the SLI is to reduce cost by requiring the engine(s) to be easier (Le. less expensive) to operate and maintain. The most effective means of accomplishing this goal is to infuse the operability and maintainability features into the engine design from the start. This paper discusses some of the operational issues relevant to a reusable LOx/LH2 main engine, and the means by which their impact is mitigated in the design phase.

The Nuclear Cryogenic Propulsion Stage

Science.gov (United States)

Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Borowski, Stanley K.; Scott, John

2014-01-01

The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced Nuclear Electric Propulsion (NEP). Nuclear propulsion can be affordable and viable compared to other propulsion systems and must overcome a biased public fear due to hyper-environmentalism and a false perception of radiation and explosion risk.

Optimal Control Strategy for Marine Ssp Podded Propulsion Motor Based on Strong Tracking-Epf

Directory of Open Access Journals (Sweden)

Yao Wenlong

2015-09-01

Full Text Available Aiming at the non-linearity of state equation and observation equation of SSP (Siemen Schottel Propulsor propulsion motor, an improved particle filter algorithm based on strong tracking extent Kalman filter (ST-EKF was presented, and it was imported into the marine SSP propulsion motor control system. The strong tracking filter was used to update particles in the new algorithm and produce importance densities. As a result, the problems of particle degeneracy and sample impoverishment were ameliorated, the propulsion motor states and the rotor resistance were estimated simultaneously using strong track filter (STF, and the tracking ability of marine SSP propulsion motor control system was improved. Simulation result shown that the improved EPF algorithm was not only improving the prediction accuracy of the motor states and the rotor resistance, but also it can satisfy the requirement of navigation in harbor. It had the better accuracy than EPF algorithm.

Cre-Lox Neurogenetics: 20 Years of Versatile Applications in Brain Research and Counting….

Science.gov (United States)

Tsien, Joe Z

2016-01-01

Defining and manipulating specific neurons in the brain has garnered enormous interest in recent years, because such an approach is now widely recognized as crucial for deepening our understanding of how the brain works. When I started exploring the Cre-loxP recombination for brain research in the early 1990s, it was written off as a dead-end project by a young fool. Yet over the past 20 years, Cre-lox recombination-mediated neurogenetics has emerged as one of the most powerful and versatile technology platforms for cell-specific gene knockouts, transgenic overexpression, Brainbow imaging, neural pathway tracing with retrovirus and CLARITY, chemical genetics, and optogenetics. Its popularity and greater utility in neuroscience research is also largely thanks to the NIH's bold Blueprint for Neuroscience Research Initiative to launch several Cre-driver resource projects, as well as individual laboratories and private research organizations. With newly-discovered, genetically-encoded molecules that are capable of responding to sonar and magnetic stimulation, for sonogenetics or magnetogenetics, respectively, or detecting rapid voltage changes in neurons, Cre-lox neurogenetics will continue to aid brain research for years to come.

NASA's Propulsion Research Laboratory

Science.gov (United States)

2004-01-01

The grand opening of NASA's new, world-class laboratory for research into future space transportation technologies located at the Marshall Space Flight Center (MSFC) in Huntsville, Alabama, took place in July 2004. The state-of-the-art Propulsion Research Laboratory (PRL) serves as a leading national resource for advanced space propulsion research. Its purpose is to conduct research that will lead to the creation and development of innovative propulsion technologies for space exploration. The facility is the epicenter of the effort to move the U.S. space program beyond the confines of conventional chemical propulsion into an era of greatly improved access to space and rapid transit throughout the solar system. The laboratory is designed to accommodate researchers from across the United States, including scientists and engineers from NASA, the Department of Defense, the Department of Energy, universities, and industry. The facility, with 66,000 square feet of useable laboratory space, features a high degree of experimental capability. Its flexibility allows it to address a broad range of propulsion technologies and concepts, such as plasma, electromagnetic, thermodynamic, and propellant propulsion. An important area of emphasis is the development and utilization of advanced energy sources, including highly energetic chemical reactions, solar energy, and processes based on fission, fusion, and antimatter. The Propulsion Research Laboratory is vital for developing the advanced propulsion technologies needed to open up the space frontier, and sets the stage of research that could revolutionize space transportation for a broad range of applications.

Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity.

Directory of Open Access Journals (Sweden)

Silvia Biocca

Full Text Available The human lectin-like oxidized low density lipoprotein receptor 1 LOX-1, encoded by the ORL1 gene, is the major scavenger receptor for oxidized low density lipoprotein in endothelial cells. Here we report on the functional effects of a coding SNP, c.501G>C, which produces a single amino acid change (K>N at codon 167. Our study was aimed at elucidating whether the c.501G>C polymorphism changes the binding affinity of LOX-1 receptor altering its function. The presence of p.K167N mutation reduces ox-LDL binding and uptake. Ox-LDL activated extracellular signal-regulated kinases 1 and 2 (ERK 1/2 is inhibited. Furthermore, ox-LDL induced biosynthesis of LOX-1 receptors is dependent on the p.K167N variation. In human macrophages, derived from c.501G>C heterozygous individuals, the ox-LDL induced LOX-1 46 kDa band is markedly lower than in induced macrophages derived from c.501G>C controls. Investigation of p.K167N mutation through molecular dynamics simulation and electrostatic analysis suggests that the ox-LDL binding may be attributed to the coupling between the electrostatic potential distribution and the asymmetric flexibility of the basic spine residues. The N/N-LOX-1 mutant has either interrupted electrostatic potential and asymmetric fluctuations of the basic spine arginines.

Software To Secure Distributed Propulsion Simulations

Science.gov (United States)

Blaser, Tammy M.

2003-01-01

Distributed-object computing systems are presented with many security threats, including network eavesdropping, message tampering, and communications middleware masquerading. NASA Glenn Research Center, and its industry partners, has taken an active role in mitigating the security threats associated with developing and operating their proprietary aerospace propulsion simulations. In particular, they are developing a collaborative Common Object Request Broker Architecture (CORBA) Security (CORBASec) test bed to secure their distributed aerospace propulsion simulations. Glenn has been working with its aerospace propulsion industry partners to deploy the Numerical Propulsion System Simulation (NPSS) object-based technology. NPSS is a program focused on reducing the cost and time in developing aerospace propulsion engines

Solid propellant ignition motors for LH_2/LOX rocket engine system

OpenAIRE

ARAKI, Tetsuo; AKIBA, Ryojiro; HASHIMOTO, Yasunari; AIHARA, Kenji; TOMITA, Etsu; YASUDA, Seiichi; 荒木, 哲夫; 秋葉, 鐐二郎; 橋本, 保成; 相原, 賢二; 富田, 悦; 安田, 誠一

1983-01-01

Solid propellant ignition motors are used in the series of experiments of the 10 ton LH_2/LOX engine featured by the channel wall thrust chamber, This paper presents design specification, experiments and results obtained by actual applications of those ignition motors.

Efecto in vitro del D-002 sobre la actividad enzimática de la 5-lipoxigenasa (5-LOX Effect of D-002 on 5-lipooxygenase (5-LOX enzyme activity in vitro

Directory of Open Access Journals (Sweden)

Yohani Pérez Guerra

2012-06-01

Full Text Available Introducción: el D-002, mezcla de seis alcoholes alifáticos primarios de alto peso molecular purificada de la cera de abejas, ha mostrado efectos antiinflamatorios, sin gastrotoxicidad secundaria, enmodelos experimentales. El tratamiento oral con D-002 reduce las concentraciones de leucotrieno B4 (LTB4 en exudados pleurales de ratas con pleuresía por carragenina, sugiriendo que podría inhibir la actividad enzimática de la 5-lipooxigenasa (5-LOX, si bien los mecanismos de la acción antiinflamatoria del D-002 no habían sido aún explorados. Objetivo: evaluar el efecto in vitro del D-002 sobre la actividad de la 5-LOX, utilizando la fracción citosólica de homogenatos de hígado de ratas. Métodos: las condiciones de ensayo utilizadas fueron las siguientes: fracción citosólica (50 µg de proteína disuelta en solución reguladora borato 0,2 mol/L (pH 9 y ácido linoleico (7,8-250 mmol/L como sustrato, ensayándose muestras paralelas incubadas con Tween-20/H2O (2 % (vehículo, muestras controles, D-002 (0,9-1 000 µg/mL o Lyprinol (500 µg/mL (sustancia de referencia. La actividad enzimática se evaluó mediante el cambio de absorbancia a 234 nm producido por la formación de dienos conjugados y medido en espectrofotómetro UV-visible. Resultados: la adición in vitro del D-002 produjo una inhibición significativa, dependiente de la dosis (r= 0,980; pIntroduction: D-002, a mixture of six high molecular weight primary aliphatic alcohols purified from beeswax, has been shown to produce anti-inflammatory effects with no secondary gastrotoxicity in experimental models. Oral treatment with D-002 was effective for lowering the concentrations of B4 leukotriene (LTB4 in pleural exudates of rats with carragenin-induced pleurisy, suggesting that it could inhibit 5-lipooxigenase (5-LOX enzyme activity. The mechanisms of the anti-inflammatory action of D-002, however, had not been explored yet. Objective: to evaluate the effects of D-002 on 5-LOX

Characterization of the lipoxygenase (LOX) gene family in the Chinese white pear (Pyrus bretschneideri) and comparison with other members of the Rosaceae.

Science.gov (United States)

Li, Meng; Li, Leiting; Dunwell, Jim M; Qiao, Xin; Liu, Xing; Zhang, Shaoling

2014-06-07

Lipoxygenases (LOXs), a type of non-haem iron-containing dioxygenase, are ubiquitous enzymes in plants and participate in the formation of fruit aroma which is a very important aspect of fruit quality. Amongst the various aroma volatiles, saturated and unsaturated alcohols and aldehydes provide the characteristic aroma of the fruit. These compounds are formed from unsaturated fatty acids through oxidation, pyrolysis and reduction steps. This biosynthetic pathway involves at least four enzymes, including LOX, the enzyme responsible for lipid oxidation. Although some studies have been conducted on the LOX gene family in several species including Arabidopsis, soybean, cucumber and apple, there is no information from pear; and the evolutionary history of this gene family in the Rosaceae is still not resolved. In this study we identified 107 LOX homologous genes from five Rosaceous species (Pyrus bretschneideri, Malus × domestica, Fragaria vesca, Prunus mume and Prunus persica); 23 of these sequences were from pear. By using structure analysis, phylogenic analysis and collinearity analysis, we identified variation in gene structure and revealed the phylogenetic evolutionary relationship of this gene family. Expression of certain pear LOX genes during fruit development was verified by analysis of transcriptome data. 23 LOX genes were identified in pear and these genes were found to have undergone a duplication 30-45 MYA; most of these 23 genes are functional. Specific gene duplication was found on chromosome4 in the pear genome. Useful information was provided for future research on the evolutionary history and transgenic research on LOX genes.

Laser ignition of a multi-injector LOX/methane combustor

Science.gov (United States)

Börner, Michael; Manfletti, Chiara; Hardi, Justin; Suslov, Dmitry; Kroupa, Gerhard; Oschwald, Michael

2018-06-01

This paper reports the results of a test campaign of a laser-ignited combustion chamber with 15 shear coaxial injectors for the propellant combination LOX/methane. 259 ignition tests were performed for sea-level conditions. The igniter based on a monolithic ceramic laser system was directly attached to the combustion chamber and delivered 20 pulses with individual pulse energies of {33.2 ± 0.8 mJ } at 1064 nm wavelength and 2.3 ns FWHM pulse length. The applicability, reliability, and reusability of this ignition technology are demonstrated and the associated challenges during the start-up process induced by the oxygen two-phase flow are formulated. The ignition quality and pressure dynamics are evaluated using 14 dynamic pressure sensors distributed both azimuthally and axially along the combustion chamber wall. The influence of test sequencing on the ignition process is briefly discussed and the relevance of the injection timing of the propellants for the ignition process is described. The flame anchoring and stabilization process, as monitored using an optical probe system close to the injector faceplate connected to photomultiplier elements, is presented. For some of the ignition tests, non-uniform anchoring was detected with no influence onto the anchoring at steady-state conditions. The non-uniform anchoring can be explained by the inhomogeneous, transient injection of the two-phase flow of oxygen across the faceplate. This characteristic is verified by liquid nitrogen cold flow tests that were recorded by high-speed imaging. We conclude that by adapting the ignition sequence, laser ignition by optical breakdown of the propellants within the shear layer of a coaxial shear injector is a reliable ignition technology for LOX/methane combustors without significant over-pressure levels.

Laser ignition of a multi-injector LOX/methane combustor

Science.gov (United States)

Börner, Michael; Manfletti, Chiara; Hardi, Justin; Suslov, Dmitry; Kroupa, Gerhard; Oschwald, Michael

2018-02-01

This paper reports the results of a test campaign of a laser-ignited combustion chamber with 15 shear coaxial injectors for the propellant combination LOX/methane. 259 ignition tests were performed for sea-level conditions. The igniter based on a monolithic ceramic laser system was directly attached to the combustion chamber and delivered 20 pulses with individual pulse energies of {33.2 ± 0.8 mJ } at 1064 nm wavelength and 2.3 ns FWHM pulse length. The applicability, reliability, and reusability of this ignition technology are demonstrated and the associated challenges during the start-up process induced by the oxygen two-phase flow are formulated. The ignition quality and pressure dynamics are evaluated using 14 dynamic pressure sensors distributed both azimuthally and axially along the combustion chamber wall. The influence of test sequencing on the ignition process is briefly discussed and the relevance of the injection timing of the propellants for the ignition process is described. The flame anchoring and stabilization process, as monitored using an optical probe system close to the injector faceplate connected to photomultiplier elements, is presented. For some of the ignition tests, non-uniform anchoring was detected with no influence onto the anchoring at steady-state conditions. The non-uniform anchoring can be explained by the inhomogeneous, transient injection of the two-phase flow of oxygen across the faceplate. This characteristic is verified by liquid nitrogen cold flow tests that were recorded by high-speed imaging. We conclude that by adapting the ignition sequence, laser ignition by optical breakdown of the propellants within the shear layer of a coaxial shear injector is a reliable ignition technology for LOX/methane combustors without significant over-pressure levels.

Examination of 12-lipoxygenase (12-LOX) as a therapeutic target in non-small cell lung cancer (NSCLC): Mechanisms controlling survival and induction of apoptosis following selective inhibition

LENUS (Irish Health Repository)

Cathcart, Mary Clare

2011-06-01

Background: Platelet-type 12-LOX is an arachidonic acid metabolising enzyme resulting in the formation of 12(S)-HETE, which stimulates tumour cell adhesion, invasion and metastasis. This study aimed to examine the expression profile and role of this enzyme in NSCLC, and determine if it is a potential target for intervention. Methods: A panel of retrospective resected lung tumours was stained for 12-LOX expression by IHC. Levels of the 12-LOX metabolite, 12(S)-HETE, were examined in 50 NSCLC serum samples, and correlated with serum VEGF. A panel of NSCLC cell lines were treated with baicalein (10 uM), a selective inhibitor of 12-LOX, or 12(S)-HETE (100 ng\\/ml) and cell survival\\/proliferation examined by BrdU. Apoptosis following 12-LOX inhibition was examined by HCS and validated by FACS and DNA laddering. The effect of 12-LOX inhibition on NSCLC tumour growth and survival was examined in-vivo using an athymic nude mouse model. Gene alterations following 12-LOX inhibition in NSCLC cell lines were assessed by qPCR arrays and validated by RT-PCR. Transient transfection methods were used to examine the effects of 12-LOX overexpression in NSCLC cells. Results: 12-LOX expression was observed to a varying degree in human lung cancers of varying histological subtypes. 12(S)-HETE levels were correlated (p<0.05) with those of VEGF. Baicalein inhibited proliferation\\/survival in all cell lines, while 12(S)-HETE increased proliferation. 12-LOX inhibition increased apoptosis, indicated by a reduction in f-actin content and mitochondrial mass potential. Treatment with baicalein significantly reduced the growth of NSCLC tumours and increased overall survival in athymic nude mice. qPCR array data implicated a number of apoptosis\\/angiogenesis genes regulating these effects, including bcl-2, VEGF, integrin A2 and A4. 12-LOX overexpression resulted in an increase in VEGF secretion, confirming qPCR observations. Conclusions: 12-LOX is a survival factor\\/potential target in

Liquid oxygen LOX compatibility evaluations of aluminum lithium (Al-Li) alloys: Investigation of the Alcoa 2090 and MMC weldalite 049 alloys

Science.gov (United States)

Diwan, Ravinder M.

1989-01-01

The behavior of liquid oxygen (LOX) compatibility of aluminum lithium (Al-Li) alloys is investigated. Alloy systems of Alcoa 2090, vintages 1 to 3, and of Martin Marietta Corporation (MMC) Weldalite 049 were evaluated for their behavior related to the LOX compatibility employing liquid oxygen impact test conditions under ambient pressures and up to 1000 psi. The developments of these aluminum lithium alloys are of critical and significant interest because of their lower densities and higher specific strengths and improved mechanical properties at cryogenic temperatures. Of the different LOX impact tests carried out at the Marshall Space Flight Center (MSFC), it is seen that in certain test conditions at higher pressures, not all Al-Li alloys are LOX compatible. In case of any reactivity, it appears that lithium makes the material more sensitive at grain boundaries due to microstructural inhomogeneities and associated precipitate free zones (PFZ). The objectives were to identify and rationalize the microstructural mechanisms that could be relaxed to LOX compatibility behavior of the alloy system in consideration. The LOX compatibility behavior of Al-Li 2090 and Weldalite 049 is analyzed in detail using microstructural characterization techniques with light optical metallography, scanning electron microscopy (SEM), electron microprobe analysis, and surface studies using secondary ion mass spectrometry (SIMS), electron spectroscopy in chemical analysis (ESCA) and Auger electron spectroscopy (AES). Differences in the behavior of these aluminum lithium alloys are assessed and related to their chemistry, heat treatment conditions, and microstructural effects.

Adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells.

Science.gov (United States)

Long, Qifang; Yang, Ru; Lu, Weixian; Zhu, Weipei; Zhou, Jundong; Zheng, Cui; Zhou, Dongmei; Yu, Ling; Wu, Jinchang

2017-01-01

Cancer stem cells are a small subset of cancer cells that contribute to cancer progression, metastasis, chemoresistance and recurrence. CD133-positive (CD133+) ovarian cancer cells have been identified as ovarian cancer stem cells. Adenovirus-mediated gene therapy is an innovative therapeutic method for cancer treatment. In the present study, we aimed to develop a new gene therapy to specifically eliminate CD133+ ovarian cancer stem cells by targeting CD133. We used the Cre/LoxP system to augment the selective expression of the truncated Bid (tBid) gene as suicide gene therapy in CD133+ ovarian cancer stem cells. The adenovirus (Ad)-CD133-Cre expressing Cre recombinase under the control of the CD133 promoter and Ad-CMV-LoxP-Neo-LoxP-tBid expressing tBid under the control of the CMV promoter were successfully constructed using the Cre/LoxP switching system. The co-infection of Ad-CMV-LoxP-Neo-LoxP-tBid and Ad-CD133-Cre selectively induced tBid overexpression, which inhibited cell growth and triggered the cell apoptosis of CD133+ ovarian cancer stem cells. The Cre/LoxP system-mediated tBid overexpression activated the pro-apoptotic signaling pathway and augmented the cytotoxic effect of cisplatin in CD133+ ovarian cancer stem cells. Furthermore, in xenograft experiments, co-infection with the two recombinant adenoviruses markedly suppressed tumor growth in vivo and promoted cell apoptosis in tumor tissues. Taken together, the present study provides evidence that the adenovirus-mediated tBid overexpression induced by the Cre/LoxP system can effectively eliminate CD133+ ovarian cancer stem cells, representing a novel therapeutic strategy for the treatment of ovarian cancer.

A Conceptual Tree of Laser Propulsion

International Nuclear Information System (INIS)

Pakhomov, Andrew V.; Sinko, John E.

2008-01-01

An original attempt to develop a conceptual tree for laser propulsion is offered. The tree provides a systematic view for practically all possible laser propulsion concepts and all inter-conceptual links, based on propellant phases and phase transfers. It also helps to see which fields of laser propulsion have been already thoroughly explored, where the next effort must be applied, and which paths should be taken with proper care or avoided entirely

NASA Propulsion Sub-System Concept Studies and Risk Reduction Activities for Resource Prospector Lander

Science.gov (United States)

Trinh, Huu P.

2015-01-01

NASA's exploration roadmap is focused on developing technologies and performing precursor missions to advance the state of the art for eventual human missions to Mars. One of the key components of this roadmap is various robotic missions to Near-Earth Objects, the Moon, and Mars to fill in some of the strategic knowledge gaps. The Resource Prospector (RP) project is one of these robotic precursor activities in the roadmap. RP is a multi-center and multi-institution project to investigate the polar regions of the Moon in search of volatiles. The mission is rated Class D and is approximately 10 days, assuming a five day direct Earth to Moon transfer. Because of the mission cost constraint, a trade study of the propulsion concepts was conducted with a focus on available low-cost hardware for reducing cost in development, while technical risk, system mass, and technology advancement requirements were also taken into consideration. The propulsion system for the lander is composed of a braking stage providing a high thrust to match the lander's velocity with the lunar surface and a lander stage performing the final lunar descent. For the braking stage, liquid oxygen (LOX) and liquid methane (LCH4) propulsion systems, derived from the Morpheus experimental lander, and storable bi-propellant systems, including the 4th stage Peacekeeper (PK) propulsion components and Space Shuttle orbital maneuvering engine (OME), and a solid motor were considered for the study. For the lander stage, the trade study included miniaturized Divert Attitude Control System (DACS) thrusters (Missile Defense Agency (MDA) heritage), their enhanced thruster versions, ISE-100 and ISE-5, and commercial-off-the-shelf (COTS) hardware. The lowest cost configuration of using the solid motor and the PK components while meeting the requirements was selected. The reference concept of the lander is shown in Figure 1. In the current reference configuration, the solid stage is the primary provider of delta

Highlights from a Mach 4 Experimental Demonstration of Inlet Mode Transition for Turbine-Based Combined Cycle Hypersonic Propulsion

Science.gov (United States)

Foster, Lancert E.; Saunders, John D., Jr.; Sanders, Bobby W.; Weir, Lois J.

2012-01-01

NASA is focused on technologies for combined cycle, air-breathing propulsion systems to enable reusable launch systems for access to space. Turbine Based Combined Cycle (TBCC) propulsion systems offer specific impulse (Isp) improvements over rocket-based propulsion systems in the subsonic takeoff and return mission segments along with improved safety. Among the most critical TBCC enabling technologies are: 1) mode transition from the low speed propulsion system to the high speed propulsion system, 2) high Mach turbine engine development and 3) innovative turbine based combined cycle integration. To address these challenges, NASA initiated an experimental mode transition task including analytical methods to assess the state-of-the-art of propulsion system performance and design codes. One effort has been the Combined-Cycle Engine Large Scale Inlet Mode Transition Experiment (CCE-LIMX) which is a fully integrated TBCC propulsion system with flowpath sizing consistent with previous NASA and DoD proposed Hypersonic experimental flight test plans. This experiment was tested in the NASA GRC 10 by 10-Foot Supersonic Wind Tunnel (SWT) Facility. The goal of this activity is to address key hypersonic combined-cycle engine issues including: (1) dual integrated inlet operability and performance issues-unstart constraints, distortion constraints, bleed requirements, and controls, (2) mode-transition sequence elements caused by switching between the turbine and the ramjet/scramjet flowpaths (imposed variable geometry requirements), and (3) turbine engine transients (and associated time scales) during transition. Testing of the initial inlet and dynamic characterization phases were completed and smooth mode transition was demonstrated. A database focused on a Mach 4 transition speed with limited off-design elements was developed and will serve to guide future TBCC system studies and to validate higher level analyses.

Simultaneous and Sequential Integration by Cre/loxP Site-Specific Recombination in Saccharomyces cerevisiae.

Science.gov (United States)

Choi, Ho-Jung; Kim, Yeon-Hee

2018-05-28

A Cre/ loxP -δ-integration system was developed to allow sequential and simultaneous integration of a multiple gene expression cassette in Saccharomyces cerevisiae . To allow repeated integrations, the reusable Candida glabrata MARKER ( CgMARKER ) carrying loxP sequences was used, and the integrated CgMARKER was efficiently removed by inducing Cre recombinase. The XYLP and XYLB genes encoding endoxylanase and β-xylosidase, respectively, were used as model genes for xylan metabolism in this system, and the copy number of these genes was increased to 15.8 and 16.9 copies/cell, respectively, by repeated integration. This integration system is a promising approach for the easy construction of yeast strains with enhanced metabolic pathways through multicopy gene expression.

Structural modeling and fuzzy-logic based diagnosis of a ship propulsion benchmark

DEFF Research Database (Denmark)

Izadi-Zamanabadi, Roozbeh; Blanke, M.; Katebi, S.D.

2000-01-01

An analysis of structural model of a ship propulsion benchmark leads to identifying the subsystems with inherent redundant information. For a nonlinear part of the system, a Fuzzy logic based FD algorithm with adaptive threshold is employed. The results illustrate the applicability of structural...

Self-excising Cre/mutant lox marker recycling system for multiple gene integrations and consecutive gene deletions in Aspergillus oryzae.

Science.gov (United States)

Zhang, Silai; Ban, Akihiko; Ebara, Naoki; Mizutani, Osamu; Tanaka, Mizuki; Shintani, Takahiro; Gomi, Katsuya

2017-04-01

In this study, we developed a self-excising Cre/loxP-mediated marker recycling system with mutated lox sequences to introduce a number of biosynthetic genes into Aspergillus oryzae. To construct the self-excising marker cassette, both the selectable marker, the Aspergillus nidulans adeA gene, and the Cre recombinase gene (cre), conditionally expressed by the xylanase-encoding gene promoter, were designed to be located between the mutant lox sequences, lox66 and lox71. However, construction of the plasmid failed, possibly owing to a slight expression of cre downstream of the fungal gene promoter in Escherichia coli. Hence, to avoid the excision of the cassette in E. coli, a 71-bp intron of the A. oryzae xynG2 gene was inserted into the cre gene. The A. oryzae adeA deletion mutant was transformed with the resulting plasmid in the presence of glucose, and the transformants were cultured in medium containing xylose as the sole carbon source. PCR analysis of genomic DNA from resultant colonies revealed the excision of both the marker and Cre expression construct, indicating that the self-excising marker cassette was efficient at removing the selectable marker. Using the marker recycling system, hyperproduction of kojic acid could be achieved in A. oryzae by the introduction of two genes that encode oxidoreductase and transporter. Furthermore, we also constructed an alternative marker recycling cassette bearing the A. nidulans pyrithiamine resistant gene (ptrA) as a dominant selectable marker. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Research on applications of rectangular beam in micro laser propulsion

International Nuclear Information System (INIS)

Jiao, L.; Cai, J.; Ma, H.H.; Li, G.X.; Li, L.; Shen, Z.W.; Tang, Z.P.

2014-01-01

Highlights: • Diode laser bar of 808 nm is introduced into the micro laser propulsion field. • Double base propellant (DBP) coating with BOPP substrate was obtained. • The combination of laser power and energy decides the propulsion performance. • The new rectangular beam prefers to produce higher impulse. - Abstract: Micro laser propulsion is a new technology with brilliant future. In order to reduce the thruster mass and volume further, laser bar is introduced into the micro laser propulsion field. A new kind of 220 × 20 μm rectangular beam of 808 nm was obtained by oval lens compressing the light of diode at fast axes and slow axes. The effect of laser power, energy and coating thickness of double base propellant on propulsion performance was studied. Propulsion performance of double base propellant under static and dynamic mode shows some different characters. Compared to round beam, the new beam prefers to produce higher impulse. Ablation efficiency of DBP shows better performance in short laser duration. The combination of power density and energy density decides the laser propulsion performance. The new rectangular beam is appropriate for millisecond micro-laser propulsion

Use of Cre/loxP recombination to swap cell binding motifs on the adenoviral capsid protein IX

International Nuclear Information System (INIS)

Poulin, Kathy L.; Tong, Grace; Vorobyova, Olga; Pool, Madeline; Kothary, Rashmi; Parks, Robin J.

2011-01-01

We used Cre/loxP recombination to swap targeting ligands present on the adenoviral capsid protein IX (pIX). A loxP-flanked sequence encoding poly-lysine (pK-binds heparan sulfate proteoglycans) was engineered onto the 3'-terminus of pIX, and the resulting fusion protein allowed for routine virus propagation. Growth of this virus on Cre-expressing cells removed the pK coding sequence, generating virus that could only infect through alternative ligands, such as a tyrosine kinase receptor A (TrkA)-binding motif engineered into the capsid fibre protein for enhanced infection of neuronal cells. We used a similar approach to swap the pK motif on pIX for a sequence encoding a single-domain antibody directed towards CD66c for targeted infection of cancer cells; Cre-mediated removal of the pK-coding sequence simultaneously placed the single-domain antibody coding sequence in frame with pIX. Thus, we have developed a simple method to propagate virus lacking native viral tropism but containing cell-specific binding ligands. - Highlights: → We describe a method to grow virus lacking native tropism but containing novel cell-binding ligands. → Cre/loxP recombination was used to modify the adenovirus genome. → A targeting ligand present on capsid protein IX was removed or replaced using recombination. → Cre-loxP was also used to 'swap' the identity of the targeting ligand present on pIX.

Distributed propulsion for ships

OpenAIRE

Nylund, Vilde

2017-01-01

It is anticipated that using distributed electric propulsion (DEP) on conventional ships will increase the total propulsive efficiency. This is mainly due to two reasons; firstly, because the total propeller disk area can be increased. Secondly, because each propeller can be optimised for the local wake where it is operating. In this work, the benefits of using DEP has been investigated for a 14 000 TEU container ship. Based on a literary study of the present state of propeller modelling ...

Propulsive efficiency of frog swimming with different feet and swimming patterns

Directory of Open Access Journals (Sweden)

Fan Jizhuang

2017-04-01

Full Text Available Aquatic and terrestrial animals have different swimming performances and mechanical efficiencies based on their different swimming methods. To explore propulsion in swimming frogs, this study calculated mechanical efficiencies based on data describing aquatic and terrestrial webbed-foot shapes and swimming patterns. First, a simplified frog model and dynamic equation were established, and hydrodynamic forces on the foot were computed according to computational fluid dynamic calculations. Then, a two-link mechanism was used to stand in for the diverse and complicated hind legs found in different frog species, in order to simplify the input work calculation. Joint torques were derived based on the virtual work principle to compute the efficiency of foot propulsion. Finally, two feet and swimming patterns were combined to compute propulsive efficiency. The aquatic frog demonstrated a propulsive efficiency (43.11% between those of drag-based and lift-based propulsions, while the terrestrial frog efficiency (29.58% fell within the range of drag-based propulsion. The results illustrate the main factor of swimming patterns for swimming performance and efficiency.

Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

OpenAIRE

Chu, Chih-Sheng; Wang, Yu-Chen; Lu, Long-Sheng; Walton, Brian; Yilmaz, H. Ramazan; Huang, Roger Y.; Sawamura, Tatsuya; Dixon, Richard A. F.; Lai, Wen-Ter; Chen, Chu-Huang; Lu, Jonathan

2013-01-01

Objectives Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1. Methods and Results Plasma LDL sa...

Propulsion Systems Panel deliberations

Science.gov (United States)

Bianca, Carmelo J.; Miner, Robert; Johnston, Lawrence M.; Bruce, R.; Dennies, Daniel P.; Dickenson, W.; Dreshfield, Robert; Karakulko, Walt; Mcgaw, Mike; Munafo, Paul M.

1993-01-01

The Propulsion Systems Panel was established because of the specialized nature of many of the materials and structures technology issues related to propulsion systems. This panel was co-chaired by Carmelo Bianca, MSFC, and Bob Miner, LeRC. Because of the diverse range of missions anticipated for the Space Transportation program, three distinct propulsion system types were identified in the workshop planning process: liquid propulsion systems, solid propulsion systems and nuclear electric/nuclear thermal propulsion systems.

Nuclear merchant ship propulsion

International Nuclear Information System (INIS)

Schroeder, E.; Jager, W.; Schafstall, H.G.

1977-01-01

The operation of about 300 nuclear naval vessels has proven the feasibility of nuclear ship propulsion. Until now six non military ships have been built or are under construction. In the Soviet Union two nuclear icebreakers are in operation, and a third one is under construction. In the western world three prototype merchant ships have been built. Of these ships only the NS OTTO HAHN is in operation and provides valuable experience for future large scale use of nuclear merchant ship propulsion. In many countries studies and plans are made for future nuclear merchant ships. Types of vessels investigated are large containerships, tankers and specialized ships like icebreakers or ice-breaking ships. The future of nuclear merchant ship propulsion depends on three interrelated items: (1) nuclear ship technology; (2) economy of nuclear ship propulsion; (3) legal questions. Nuclear merchant ship technology is based until now on standard ship technology and light water reactor technology. Except for special questions due to the non-stationary type of the plant entirely new problems do not arise. This has been proven by the recent conceptual licensing procedure for a large nuclear containership in Germany. The economics of nuclear propulsion will be under discussion until they are proven by the operation of privately owned lead ships. Unsolved legal questions e.g. in connection with port entry permissions are at present another problem for nuclear shipping. Efforts are made to solve these questions on an international basis. The future development of nuclear energy electricity production in large land based plants will stimulate the employment of smaller units. Any future development of long distance sea transport will have to take this opportunity of a reliable and economic energy supply into account

Arabidopsis CPR5 independently regulates seed germination and postgermination arrest of development through LOX pathway and ABA signaling.

Directory of Open Access Journals (Sweden)

Guilan Gao

Full Text Available The phytohormone abscisic acid (ABA and the lipoxygenases (LOXs pathway play important roles in seed germination and seedling growth and development. Here, we reported on the functional characterization of Arabidopsis CPR5 in the ABA signaling and LOX pathways. The cpr5 mutant was hypersensitive to ABA in the seed germination, cotyledon greening and root growth, whereas transgenic plants overexpressing CPR5 were insensitive. Genetic analysis demonstrated that CPR5 gene may be located downstream of the ABI1 in the ABA signaling pathway. However, the cpr5 mutant showed an ABA independent drought-resistant phenotype. It was also found that the cpr5 mutant was hypersensitive to NDGA and NDGA treatment aggravated the ABA-induced delay in the seed germination and cotyledon greening. Taken together, these results suggest that the CPR5 plays a regulatory role in the regulation of seed germination and early seedling growth through ABA and LOX pathways independently.

The mechanism of long non-coding RNA MEG3 for neurons apoptosis caused by hypoxia: mediated by miR-181b-12/15-LOX signaling pathway

Directory of Open Access Journals (Sweden)

Xiaomin Liu

2016-09-01

Full Text Available Objective: lncRNAs are recently thought to play a significant role in cellular homeostasis during pathological process of diseases by competing inhibiting miRNA function. The aim of present study was to assess the function of long non-coding RNA (lncRNA MEG3 and its functional interaction with microRNA-181b in cerebral ischemic infarct of mice and hypoxia-induced neurons apoptosis. Methods: To address this question, we performed the experiments with in vivo middle cerebral artery occlusion (MCAO mice model and in vitro oxygen-glucose deprivation (OGD-cultured neuronal HT22 cell line. Relative expression of MEG3, miR-181b and 12/15-LOX (lipoxygenase mRNA was determined using quantitative RT-PCR. Western blot was used to evaluate 12/15-LOX protein expression. TUNEL assay was performed to assess cell apoptosis.Results: In both MCAO mice and OGD-cultured HT22 cell, ischemia or hypoxia treatment results in a time-dependent increase in MEG3 and 12/15-LOX expression and decrease in miR-181b expression. Knockdown of MEG3 contributes to attenuation of hypoxia-induced apoptosis of HT22 cell. Also, expression level of MEG3 negatively correlated with miR-181b expression and positively correlated with 12/15-LOX expression. In contrary to MEG3, miR-181b overexpression attenuated hypoxia-induced HT22 cell apoptosis, as well as suppressed hypoxia-induced increase in 12/15-LOX expression. By luciferase reporter assay, we concluded that miR-181b directly binds to 12/15-LOX 3’-UTR, thereby negatively regulates 12/15-LOX expression. Conclusion: Our data suggested that long non-coding RNA MEG3 functions as a competing endogenous RNA for miR-181b to regulate 12/15-LOX expression in middle cerebral artery occlusion-induced ischemic infarct of brain nerve cells.

Propulsion Laboratory

Data.gov (United States)

Federal Laboratory Consortium — The Propulsion Lab simulates field test conditions in a controlled environment, using standardized or customized test procedures. The Propulsion Lab's 11 cells can...

LOX Gene Transcript Accumulation in Olive (Olea europaea L. Fruits at Different Stages of Maturation: Relationship between Volatile Compounds, Environmental Factors, and Technological Treatments for Oil Extraction

Directory of Open Access Journals (Sweden)

Innocenzo Muzzalupo

2012-01-01

Full Text Available The quality of olive oil is influenced by genetic and environmental factors and by the maturation state of drupes, but it is equally affected by technological treatments of the process. This work investigates the possible correlation between olive LOX gene transcript accumulation, evaluated in fruits collected at different stages of maturation, and chemical biomarkers of its activity. During olive fruit ripening, the same genotype harvested from two different farms shows a positive linear trend between LOX relative transcript accumulation and the content of volatile compounds present in the olive oil aroma. Interestingly, a negative linear trend was observed between LOX relative transcript accumulation and the content of volatile compounds present in the olive pastes obtained from olive fruits with and without malaxation. The changes in the olive LOX transcript accumulation reveal its environmental regulation and suggest differential physiological functions for the LOXs.

Recent Advances in Airframe-Propulsion Concepts with Distributed Propulsion

OpenAIRE

Isikveren , A.T.; Seitz , A.; Bijewitz , J.; Hornung , M.; Mirzoyan , A.; Isyanov , A.; Godard , J.L.; Stückl , S.; Van Toor , J.

2014-01-01

International audience; This paper discusses design and integration associated with distributed propulsion as a means of providing motive power for future aircraft concepts. The technical work reflects activities performed within a European Commission funded Framework 7 project entitled Distributed Propulsion and Ultra-high By-Pass Rotor Study at Aircraft Level, or, DisPURSAL. In this instance, the approach of distributed propulsion includes one unique solution that integrates the fuselage wi...

Magnesium-Based Micromotors: Water-Powered Propulsion, Multifunctionality, and Biomedical and Environmental Applications.

Science.gov (United States)

Chen, Chuanrui; Karshalev, Emil; Guan, Jianguo; Wang, Joseph

2018-06-01

The new capabilities and functionalities of synthetic micro/nanomotors open up considerable opportunities for diverse environmental and biomedical applications. Water-powered micromachines are particularly attractive for realizing many of these applications. Magnesium-based motors directly use water as fuel to generate hydrogen bubbles for their propulsion, eliminating the requirement of common toxic fuels. This Review highlights the development of new Mg-based micromotors and discusses the chemistry that makes it extremely attractive for micromotor applications. Understanding these Mg properties and its transient nature is essential for controlling the propulsion efficiency, lifetime, and overall performance. The unique and attractive behavior of Mg offers significant advantages, including efficient water-powered movement, remarkable biocompatibility, controlled degradation, convenient functionalization, and built-in acid neutralization ability, and has paved the way for multifunctional micromachines for diverse real-life applications, including operation in living animals. A wide range of such Mg motor-based applications, including the detection and destruction of environmental threats, effective in-vivo cargo delivery, and autonomous release, have been demonstrated. In conclusion, the current challenges, future opportunities, and performance improvements of the Mg-based micromotors are discussed. With continuous innovation and attention to key challenges, it is expected that Mg-based motors will have a profound impact on diverse biomedical and environmental applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation of 12-Lipoxygenase (12-LOX and Plasminogen Activator Inhibitor 1 (PAI-1 as Prognostic Markers in Prostate Cancer

Directory of Open Access Journals (Sweden)

Tomasz Gondek

2014-01-01

Full Text Available In carcinoma of prostate, a causative role of platelet 12-lipoxygenase (12-LOX and plasminogen activator inhibitor 1 (PAI-1 for tumor progression has been firmly established in tumor and/or adjacent tissue. Our goal was to investigate if 12-LOX and/or PAI-1 in patient’s plasma could be used to predict outcome of the disease. The study comprised 149 patients (age 70±9 divided into two groups: a study group with carcinoma confirmed by positive biopsy of prostate (n=116 and a reference group (n=33 with benign prostatic hyperplasia (BPH. The following parameters were determined by the laboratory test in plasma or platelet-rich plasma: protein level of 12-LOX, PAI-1, thromboglobulin (TGB, prostate specific antigen (PSA, C-reactive protein (CRP, hemoglobin (HGB, and hematocrit (HCT, as well as red (RBC and white blood cells (WBC, number of platelets (PLT, international normalized ratio of blood clotting (INR, and activated partial thromboplastin time (APTT. The only difference of significance was noticed in the concentration of 12-LOX in platelet rich plasma, which was lower in cancer than in BPH group. Standardization to TGB and platelet count increases the sensitivity of the test that might be used as a biomarker to assess risk for prostate cancer in periodically monitored patients.

Saturn V First Stage S-1C LOX Fuel Tanks

Science.gov (United States)

1960-01-01

This photograph shows the Saturn V assembled LOX (Liquid Oxygen) and fuel tanks ready for transport from the Manufacturing Engineering Laboratory at Marshall Space Flight Center in Huntsville, Alabama. The tanks were then shipped to the launch site at Kennedy Space Center for a flight. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

Cre recombinase activity is inhibited in vivo but not ex vivo by a mutation in the asymmetric spacer region of the distal loxP site.

Science.gov (United States)

Arguello, Tania; Moraes, Carlos T

2015-11-01

The cre/loxP recombination system is a valuable tool used to generate tissue specific genomic rearrangements in mouse models. The deletion of a region of interest flanked by two loxP sites is accomplished by the recombinase (cre) enzyme, which binds to the inverted repeat segments of two loxP sites and recognition of a conserved TA sequence in the asymmetric central spacer region "ATAACTTCGTATA -NNNTANNN-TATACGAAGTTAT. In vivo, we found that a single T to C mutation at position 4 of the central spacer region in the distal (3') loxP site, completely inhibited the recombination reaction in two conditional mouse models. These mice were generated using a mitochondrial methionyl-tRNA formyltransferase (Mtfmt) gene targeted construct and cre transgene under the control of tissue-specific promoters: calcium/calmodulin-dependent kinase II alpha (Camk2a-cre) and myosin light polypeptide 1 (Myl1-cre). Surprisingly, transient transfection of a plasmid expressing cre in dermal fibroblasts derived from the same mutant floxed Mtfmt((loxP/loxP)) mice line, successfully deleted the region of interest. This study demonstrates the sequence specificity required in vivo, the possibility of bypassing this limitation by expressing high levels of cre recombinase ex vivo and raises concerns related to the quality control of large scale production of gene targeted constructs and mice. genesis 53:695-700, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool.

Science.gov (United States)

Yang, Fayu; Liu, Changbao; Chen, Ding; Tu, Mengjun; Xie, Haihua; Sun, Huihui; Ge, Xianglian; Tang, Lianchao; Li, Jin; Zheng, Jiayong; Song, Zongming; Qu, Jia; Gu, Feng

2017-06-16

Cre-loxP, as one of the site-specific genetic manipulation tools, offers a method to study the spatial and temporal regulation of gene expression/inactivation in order to decipher gene function. CRISPR/Cas9-mediated targeted genome engineering technologies are sparking a new revolution in biological research. Whether the traditional site-specific genetic manipulation tool and CRISPR/Cas9 could be combined to create a novel genetic tool for highly specific gene editing is not clear. Here, we successfully generated a CRISPR/Cas9-loxP system to perform gene editing in human cells, providing the proof of principle that these two technologies can be used together for the first time. We also showed that distinct non-homologous end-joining (NHEJ) patterns from CRISPR/Cas9-mediated gene editing of the targeting sequence locates at the level of plasmids (episomal) and chromosomes. Specially, the CRISPR/Cas9-mediated NHEJ pattern in the nuclear genome favors deletions (64%-68% at the human AAVS1 locus versus 4%-28% plasmid DNA). CRISPR/Cas9-loxP, a novel site-specific genetic manipulation tool, offers a platform for the dissection of gene function and molecular insights into DNA-repair pathways. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Nuclear propulsion for orbital transfer

International Nuclear Information System (INIS)

Beale, G.A.; Lawrence, T.J.

1989-01-01

The state of the art in nuclear propulsion for orbital transfer is discussed. Cryogenic propulsion, electric propulsion, solar-thermal propulsion and direct nuclear propulsion are examined in this context. New technologies with exceptional promise are addressed, emphasizing the particle test bed nuclear engine

Nuclear thermal propulsion workshop overview

International Nuclear Information System (INIS)

Clark, J.S.

1991-01-01

NASA is planning an Exploration Technology Program as part of the Space Exploration Initiative to return U.S. astronauts to the moon, conduct intensive robotic exploration of the moon and Mars, and to conduct a piloted mission to Mars by 2019. Nuclear Propulsion is one of the key technology thrust for the human mission to Mars. The workshop addresses NTP (Nuclear Thermal Rocket) technologies with purpose to: assess the state-of-the-art of nuclear propulsion concepts; assess the potential benefits of the concepts for the mission to Mars; identify critical, enabling technologies; lay-out (first order) technology development plans including facility requirements; and estimate the cost of developing these technologies to flight-ready status. The output from the workshop will serve as a data base for nuclear propulsion project planning

Materials Advance Chemical Propulsion Technology

Science.gov (United States)

2012-01-01

In the future, the Planetary Science Division of NASA's Science Mission Directorate hopes to use better-performing and lower-cost propulsion systems to send rovers, probes, and observers to places like Mars, Jupiter, and Saturn. For such purposes, a new propulsion technology called the Advanced Materials Bipropellant Rocket (AMBR) was developed under NASA's In-Space Propulsion Technology (ISPT) project, located at Glenn Research Center. As an advanced chemical propulsion system, AMBR uses nitrogen tetroxide oxidizer and hydrazine fuel to propel a spacecraft. Based on current research and development efforts, the technology shows great promise for increasing engine operation and engine lifespan, as well as lowering manufacturing costs. In developing AMBR, ISPT has several goals: to decrease the time it takes for a spacecraft to travel to its destination, reduce the cost of making the propulsion system, and lessen the weight of the propulsion system. If goals like these are met, it could result in greater capabilities for in-space science investigations. For example, if the amount (and weight) of propellant required on a spacecraft is reduced, more scientific instruments (and weight) could be added to the spacecraft. To achieve AMBR s maximum potential performance, the engine needed to be capable of operating at extremely high temperatures and pressure. To this end, ISPT required engine chambers made of iridium-coated rhenium (strong, high-temperature metallic elements) that allowed operation at temperatures close to 4,000 F. In addition, ISPT needed an advanced manufacturing technique for better coating methods to increase the strength of the engine chamber without increasing the costs of fabricating the chamber.

Utility of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) in the postmortem diagnosis of ischemic heart disease.

Science.gov (United States)

Takasu, Shojiro; Matsumoto, Sari; Kanto, Yuko; Iwadate, Kimiharu

2018-04-01

Ischemic heart disease (IHD) is a major cause of death in developed countries. Postmortem IHD diagnosis using biochemical markers is difficult because of the postmortem changes. In the present study, we investigated the utility of soluble lectin-like low-density lipoprotein receptor-1 (sLOX-1) in body fluids obtained from forensic autopsy cases. We measured pericardial fluid, urine, and serum sLOX-1 levels; these samples were obtained from medicolegal autopsy cases (n = 149, postmortem interval fluid and urine of patients with acute IHD had higher sLOX-1 levels (p fluid and urine samples obtained postmortem are useful markers of acute IHD. Copyright © 2018 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Propulsion for CubeSats

Science.gov (United States)

Lemmer, Kristina

2017-05-01

At present, very few CubeSats have flown in space featuring propulsion systems. Of those that have, the literature is scattered, published in a variety of formats (conference proceedings, contractor websites, technical notes, and journal articles), and often not available for public release. This paper seeks to collect the relevant publically releasable information in one location. To date, only two missions have featured propulsion systems as part of the technology demonstration. The IMPACT mission from the Aerospace Corporation launched several electrospray thrusters from Massachusetts Institute of Technology, and BricSAT-P from the United States Naval Academy had four micro-Cathode Arc Thrusters from George Washington University. Other than these two missions, propulsion on CubeSats has been used only for attitude control and reaction wheel desaturation via cold gas propulsion systems. As the desired capability of CubeSats increases, and more complex missions are planned, propulsion is required to accomplish the science and engineering objectives. This survey includes propulsion systems that have been designed specifically for the CubeSat platform and systems that fit within CubeSat constraints but were developed for other platforms. Throughout the survey, discussion of flight heritage and results of the mission are included where publicly released information and data have been made available. Major categories of propulsion systems that are in this survey are solar sails, cold gas propulsion, electric propulsion, and chemical propulsion systems. Only systems that have been tested in a laboratory or with some flight history are included.

Effect of workload setting on propulsion technique in handrim wheelchair propulsion.

Science.gov (United States)

van Drongelen, Stefan; Arnet, Ursina; Veeger, Dirkjan H E J; van der Woude, Lucas H V

2013-03-01

To investigate the influence of workload setting (speed at constant power, method to impose power) on the propulsion technique (i.e. force and timing characteristics) in handrim wheelchair propulsion. Twelve able-bodied men participated in this study. External forces were measured during handrim wheelchair propulsion on a motor driven treadmill at different velocities and constant power output (to test the forced effect of speed) and at power outputs imposed by incline vs. pulley system (to test the effect of method to impose power). Outcome measures were the force and timing variables of the propulsion technique. FEF and timing variables showed significant differences between the speed conditions when propelling at the same power output (p propulsion technique parameters despite an overall constant power output. Copyright © 2012 IPEM. Published by Elsevier Ltd. All rights reserved.

High-Payoff Space Transportation Design Approach with a Technology Integration Strategy

Science.gov (United States)

McCleskey, C. M.; Rhodes, R. E.; Chen, T.; Robinson, J.

2011-01-01

A general architectural design sequence is described to create a highly efficient, operable, and supportable design that achieves an affordable, repeatable, and sustainable transportation function. The paper covers the following aspects of this approach in more detail: (1) vehicle architectural concept considerations (including important strategies for greater reusability); (2) vehicle element propulsion system packaging considerations; (3) vehicle element functional definition; (4) external ground servicing and access considerations; and, (5) simplified guidance, navigation, flight control and avionics communications considerations. Additionally, a technology integration strategy is forwarded that includes: (a) ground and flight test prior to production commitments; (b) parallel stage propellant storage, such as concentric-nested tanks; (c) high thrust, LOX-rich, LOX-cooled first stage earth-to-orbit main engine; (d) non-toxic, day-of-launch-loaded propellants for upper stages and in-space propulsion; (e) electric propulsion and aero stage control.

Centralized versus distributed propulsion

Science.gov (United States)

Clark, J. P.

1982-01-01

The functions and requirements of auxiliary propulsion systems are reviewed. None of the three major tasks (attitude control, stationkeeping, and shape control) can be performed by a collection of thrusters at a single central location. If a centralized system is defined as a collection of separated clusters, made up of the minimum number of propulsion units, then such a system can provide attitude control and stationkeeping for most vehicles. A distributed propulsion system is characterized by more numerous propulsion units in a regularly distributed arrangement. Various proposed large space systems are reviewed and it is concluded that centralized auxiliary propulsion is best suited to vehicles with a relatively rigid core. These vehicles may carry a number of flexible or movable appendages. A second group, consisting of one or more large flexible flat plates, may need distributed propulsion for shape control. There is a third group, consisting of vehicles built up from multiple shuttle launches, which may be forced into a distributed system because of the need to add additional propulsion units as the vehicles grow. The effects of distributed propulsion on a beam-like structure were examined. The deflection of the structure under both translational and rotational thrusts is shown as a function of the number of equally spaced thrusters. When two thrusters only are used it is shown that location is an important parameter. The possibility of using distributed propulsion to achieve minimum overall system weight is also examined. Finally, an examination of the active damping by distributed propulsion is described.

Definition of an arcjet propulsion sub-system

International Nuclear Information System (INIS)

Price, T.W.

1989-01-01

An engineering flight demonstration of a 100 kW3 Space Reactor Power System is planned for the mid to late 1990s. An arcjet based propulsion subsystem will be included on the flight demonstraction as a secondary experiment. Two studies, sponsored by the Kay Technologies Directorate of the SDI Organization and managed by the Jet Propulsion Laboratory are currently under way to define that propulsion subsystem. The principal tasks of those contracts and the plans for two later phases, an experimental verification of the concept and a flight qualification/delivery of a flight unit, are described. 9 refs

Design and Activation of a LOX/GH Chemical Steam Generator

Science.gov (United States)

Saunders, G. P.; Mulkey, C. A.; Taylor, S. A.

2009-01-01

The purpose of this paper is to give a detailed description of the design and activation of the LOX/GH fueled chemical steam generator installed in Cell 2 of the E3 test facility at Stennis Space Center, MS (SSC). The steam generator uses a liquid oxygen oxidizer with gaseous hydrogen fuel. The combustion products are then quenched with water to create steam at pressures from 150 to 450 psig at temperatures from 350 to 750 deg F (from saturation to piping temperature limits).

LOX/hydrocarbon rocket engine analytical design methodology development and validation. Volume 2: Appendices

Science.gov (United States)

Niiya, Karen E.; Walker, Richard E.; Pieper, Jerry L.; Nguyen, Thong V.

1993-05-01

This final report includes a discussion of the work accomplished during the period from Dec. 1988 through Nov. 1991. The objective of the program was to assemble existing performance and combustion stability models into a usable design methodology capable of designing and analyzing high-performance and stable LOX/hydrocarbon booster engines. The methodology was then used to design a validation engine. The capabilities and validity of the methodology were demonstrated using this engine in an extensive hot fire test program. The engine used LOX/RP-1 propellants and was tested over a range of mixture ratios, chamber pressures, and acoustic damping device configurations. This volume contains time domain and frequency domain stability plots which indicate the pressure perturbation amplitudes and frequencies from approximately 30 tests of a 50K thrust rocket engine using LOX/RP-1 propellants over a range of chamber pressures from 240 to 1750 psia with mixture ratios of from 1.2 to 7.5. The data is from test configurations which used both bitune and monotune acoustic cavities and from tests with no acoustic cavities. The engine had a length of 14 inches and a contraction ratio of 2.0 using a 7.68 inch diameter injector. The data was taken from both stable and unstable tests. All combustion instabilities were spontaneous in the first tangential mode. Although stability bombs were used and generated overpressures of approximately 20 percent, no tests were driven unstable by the bombs. The stability instrumentation included six high-frequency Kistler transducers in the combustion chamber, a high-frequency Kistler transducer in each propellant manifold, and tri-axial accelerometers. Performance data is presented, both characteristic velocity efficiencies and energy release efficiencies, for those tests of sufficient duration to record steady state values.

Propulsion of space ships by nuclear explosion

Science.gov (United States)

Linhart, J. G.; Kravárik, J.

2005-01-01

Recent progress in the research on deuterium-tritium (D-T) inertially confined microexplosions encourages one to reconsider the nuclear propulsion of spaceships based on the concept originally proposed in the Orion project. We discuss first the acceleration of medium-sized spaceships by D-T explosions whose output is in the range of 0.1 10 t of TNT. The launching of such a ship into an Earth orbit or beyond by a large nuclear explosion in an underground cavity is sketched out in the second section of the paper, and finally we consider a hypothetical Mars mission based on these concepts. In the conclusion it is argued that propulsion based on the Orion concept only is not the best method for interplanetary travel owing to the very large number of nuclear explosion required. A combination of a super gun and subsequent rocket propulsion using advanced chemical fuels appears to be the best solution for space flights of the near future.

A photoactivatable Cre-loxP recombination system for optogenetic genome engineering.

Science.gov (United States)

Kawano, Fuun; Okazaki, Risako; Yazawa, Masayuki; Sato, Moritoshi

2016-12-01

Genome engineering techniques represented by the Cre-loxP recombination system have been used extensively for biomedical research. However, powerful and useful techniques for genome engineering that have high spatiotemporal precision remain elusive. Here we develop a highly efficient photoactivatable Cre recombinase (PA-Cre) to optogenetically control genome engineering in vivo. PA-Cre is based on the reassembly of split Cre fragments by light-inducible dimerization of the Magnet system. PA-Cre enables sharp induction (up to 320-fold) of DNA recombination and is efficiently activated even by low-intensity illumination (∼0.04 W m -2 ) or short periods of pulsed illumination (∼30 s). We demonstrate that PA-Cre allows for efficient DNA recombination in an internal organ of living mice through noninvasive external illumination using a LED light source. The present PA-Cre provides a powerful tool to greatly facilitate optogenetic genome engineering in vivo.

CORBASec Used to Secure Distributed Aerospace Propulsion Simulations

Science.gov (United States)

Blaser, Tammy M.

2003-01-01

The NASA Glenn Research Center and its industry partners are developing a Common Object Request Broker (CORBA) Security (CORBASec) test bed to secure their distributed aerospace propulsion simulations. Glenn has been working with its aerospace propulsion industry partners to deploy the Numerical Propulsion System Simulation (NPSS) object-based technology. NPSS is a program focused on reducing the cost and time in developing aerospace propulsion engines. It was developed by Glenn and is being managed by the NASA Ames Research Center as the lead center reporting directly to NASA Headquarters' Aerospace Technology Enterprise. Glenn is an active domain member of the Object Management Group: an open membership, not-for-profit consortium that produces and manages computer industry specifications (i.e., CORBA) for interoperable enterprise applications. When NPSS is deployed, it will assemble a distributed aerospace propulsion simulation scenario from proprietary analytical CORBA servers and execute them with security afforded by the CORBASec implementation. The NPSS CORBASec test bed was initially developed with the TPBroker Security Service product (Hitachi Computer Products (America), Inc., Waltham, MA) using the Object Request Broker (ORB), which is based on the TPBroker Basic Object Adaptor, and using NPSS software across different firewall products. The test bed has been migrated to the Portable Object Adaptor architecture using the Hitachi Security Service product based on the VisiBroker 4.x ORB (Borland, Scotts Valley, CA) and on the Orbix 2000 ORB (Dublin, Ireland, with U.S. headquarters in Waltham, MA). Glenn, GE Aircraft Engines, and Pratt & Whitney Aircraft are the initial industry partners contributing to the NPSS CORBASec test bed. The test bed uses Security SecurID (RSA Security Inc., Bedford, MA) two-factor token-based authentication together with Hitachi Security Service digital-certificate-based authentication to validate the various NPSS users. The test

Manual wheelchair propulsion patterns on natural surfaces during start-up propulsion.

Science.gov (United States)

Koontz, Alicia M; Roche, Bailey M; Collinger, Jennifer L; Cooper, Rory A; Boninger, Michael L

2009-11-01

To classify propulsion patterns over surfaces encountered in the natural environment during start-up and compare selected biomechanical variables between pattern types. Case series. National Veterans Wheelchair Games, Minneapolis, MN, 2005. Manual wheelchair users (N=29). Subjects pushed their wheelchairs from a resting position over high-pile carpet, over linoleum, and up a ramp with a 5 degrees incline while propulsion kinematics and kinetics were recorded with a motion capture system and an instrumented wheel. Three raters classified the first 3 strokes as 1 of 4 types on each surface: arc, semicircular (SC), single looping over propulsion (SL), and double looping over propulsion (DL). The Fisher exact test was used to assess pattern changes between strokes and surface type. A multiple analysis of variance test was used to compare peak and average resultant force and moment about the hub, average wheel velocity, stroke frequency, contact angle, and distance traveled between stroke patterns. SL was the most common pattern used during start-up propulsion (44.9%), followed by arc (35.9%), DL (14.1%), and SC (5.1%). Subjects who dropped their hands below the rim during recovery achieved faster velocities and covered greater distances (.016propulsion patterns is a difficult task that should use multiple raters. In addition, propulsion patterns change during start-up, with an arc pattern most prevalent initially. The biomechanical findings in this study agree with current clinical guidelines that recommend training users to drop the hand below the pushrim during recovery.

Resistance to Fusarium verticillioides and fumonisin accumulation in maize inbred lines involves an earlier and enhanced expression of lipoxygenase (LOX) genes.

Science.gov (United States)

Maschietto, Valentina; Marocco, Adriano; Malachova, Alexandra; Lanubile, Alessandra

2015-09-01

Fusarium verticillioides causes ear rot in maize and contaminates the kernels with the fumonisin mycotoxins. It is known that plant lipoxygenase (LOX)-derived oxylipins regulate defence against pathogens and that the host-pathogen lipid cross-talk influences the pathogenesis. The expression profiles of fifteen genes of the LOX pathway were studied in kernels of resistant and susceptible maize lines, grown in field condition, at 3, 7 and 14 days post inoculation (dpi) with F. verticillioides. Plant defence responses were correlated with the pathogen growth, the expression profiles of fungal FUM genes for fumonisin biosynthesis and fumonisin content in the kernels. The resistant genotype limited fungal growth and fumonisin accumulation between 7 and 14 dpi. Pathogen growth became exponential in the susceptible line after 7 dpi, in correspondence with massive transcription of FUM genes and fumonisins augmented exponentially at 14 dpi. LOX pathway genes resulted strongly induced after pathogen inoculation in the resistant line at 3 and 7 dpi, whilst in the susceptible line the induction was reduced or delayed at 14 dpi. In addition, all genes resulted overexpressed before infection in kernels of the resistant genotype already at 3 dpi. The results suggest that resistance in maize may depend on an earlier activation of LOX genes and genes for jasmonic acid biosynthesis. Copyright © 2015 Elsevier GmbH. All rights reserved.

Integrated Main Propulsion System Performance Reconstruction Process/Models

Science.gov (United States)

Lopez, Eduardo; Elliott, Katie; Snell, Steven; Evans, Michael

2013-01-01

The Integrated Main Propulsion System (MPS) Performance Reconstruction process provides the MPS post-flight data files needed for postflight reporting to the project integration management and key customers to verify flight performance. This process/model was used as the baseline for the currently ongoing Space Launch System (SLS) work. The process utilizes several methodologies, including multiple software programs, to model integrated propulsion system performance through space shuttle ascent. It is used to evaluate integrated propulsion systems, including propellant tanks, feed systems, rocket engine, and pressurization systems performance throughout ascent based on flight pressure and temperature data. The latest revision incorporates new methods based on main engine power balance model updates to model higher mixture ratio operation at lower engine power levels.

Tools for advanced simulations to nuclear propulsion systems in rockets

International Nuclear Information System (INIS)

Torres Sepulveda, A.; Perez Vara, R.

2004-01-01

While chemical propulsion rockets have dominated space exploration, other forms of rocket propulsion based on nuclear power, electrostatic and magnetic drive, and other principles besides chemical reactions, have been considered from the earliest days of the field. The goal of most of these advanced rocket propulsion schemes is improved efficiency through higher exhaust velocities, in order to reduce the amount of fuel the rocket vehicle needs to carry, though generally at the expense of high thrust. Nuclear propulsion seems to be the most promising short term technology to plan realistic interplanetary missions. The development of a nuclear electric propulsion spacecraft shall require the development of models to analyse the mission and to understand the interaction between the related subsystems (nuclear reactor, electrical converter, power management and distribution, and electric propulsion) during the different phases of the mission. This paper explores the modelling of a nuclear electric propulsion (NEP) spacecraft type using EcosimPro simulation software. This software is a multi-disciplinary simulation tool with a powerful object-oriented simulation language and state-of-the-art solvers. EcosimPro is the recommended ESA simulation tool for environmental Control and Life Support Systems (ECLSS) and has been used successfully within the framework of the European activities of the International Space Station programme. Furthermore, propulsion libraries for chemical and electrical propulsion are currently being developed under ESA contracts to set this tool as standard usage in the propulsion community. At present, there is not any workable NEP spacecraft, but a standardized-modular, multi-purpose interplanetary spacecraft for post-2000 missions, called ISC-2000, has been proposed in reference. The simulation model presented on this paper is based on the preliminary designs for this spacecraft. (Author)

Operational Issues in the Development of a Cost-Effective Reusable LOX/LH2 Engine

Science.gov (United States)

Ballard, Richard O.

2005-01-01

Contents include the following: SLI initiated under NASA Research Announcement (NRA) 8-30. Strategic Objectives. Make spaceflight safer (1 in 10000 mission LOV). Make spaceflight cheaper ($1000/lb payload). Two prototype LOX/LH2 engine systems funded under Cycle-1 of NRA8-30. COBRA (Pratt & Whitney / Aerojet). RS-83 (Rocketdyne).

The SMPR for the naval propulsion; Les RPMP pour la propulsion navale

Energy Technology Data Exchange (ETDEWEB)

Gauducheau, B. [Technicatome, Centre d' Etudes Nucleaires de Saclay, 91 - Gif sur Yvette (France)

2002-07-01

The first controlled application of the fissile energy was the american nuclear reactor for the ship propulsion. Since the sixties, the France begun researches to secure the independence of its nuclear propulsion program. The historical aspects, the french program management and the perspectives of the ship nuclear propulsion, are discussed in this paper. (A.L.B.)

Observer-based FDI for Gain Fault Detection in Ship Propulsion Benchmark

DEFF Research Database (Denmark)

Lootsma, T.F.; Izadi-Zamanabadi, Roozbeh; Nijmeijer, H.

2001-01-01

A geometric approach for input-affine nonlinear systems is briefly described and then applied to a ship propulsion benchmark. The obtained results are used to design a diagnostic nonlinear observer for successful FDI of the diesel engine gain fault......A geometric approach for input-affine nonlinear systems is briefly described and then applied to a ship propulsion benchmark. The obtained results are used to design a diagnostic nonlinear observer for successful FDI of the diesel engine gain fault...

Observer-based FDI for Gain Fault Detection in Ship Propulsion Benchmark

DEFF Research Database (Denmark)

Lootsma, T.F.; Izadi-Zamanabadi, Roozbeh; Nijmeijer, H.

2001-01-01

A geometric approach for input-affine nonlinear systems is briefly described and then applied to a ship propulsion benchmark. The obtained results are used to design a diagnostic nonlinear observer for successful FDI of the diesel engine gain fault.......A geometric approach for input-affine nonlinear systems is briefly described and then applied to a ship propulsion benchmark. The obtained results are used to design a diagnostic nonlinear observer for successful FDI of the diesel engine gain fault....

Nuclear propulsion technology development - A joint NASA/Department of Energy project

Science.gov (United States)

Clark, John S.

1992-01-01

NASA-Lewis has undertaken the conceptual development of spacecraft nuclear propulsion systems with DOE support, in order to establish the bases for Space Exploration Initiative lunar and Mars missions. This conceptual evolution project encompasses nuclear thermal propulsion (NTP) and nuclear electric propulsion (NEP) systems. A technology base exists for NTP in the NERVA program files; more fundamental development efforts are entailed in the case of NEP, but this option is noted to offer greater advantages in the long term.

Nuclear electric propulsion for planetary science missions: NASA technology program planning

International Nuclear Information System (INIS)

Doherty, M.P.

1993-05-01

This paper presents the status of technology program planning to develop those Nuclear Electric Propulsion technologies needed to meet the advanced propulsion system requirements for planetary science missions in the next century. The technology program planning is based upon technologies with significant development heritage: ion electric propulsion and the SP-100 space nuclear power technologies. Detailed plans are presented for the required ion electric propulsion technology development and demonstration. Closer coordination between space nuclear power and space electric propulsion technology programs is a necessity as technology plans are being further refined in light of NEP concept definition and possible early NEP flight activities

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly

DEFF Research Database (Denmark)

Miller, Bryan W; Morton, Jennifer P; Pinese, Mark

2015-01-01

of a cure, but most will die of recurrent or metastatic disease. Hence, preventing metastatic disease in these patients would be of significant benefit. Using principal component analysis (PCA), we identified a LOX/hypoxia signature associated with poor patient survival in resectable patients. We found...

Computational fluid dynamics for propulsion technology: Geometric grid visualization in CFD-based propulsion technology research

Science.gov (United States)

Ziebarth, John P.; Meyer, Doug

1992-01-01

The coordination is examined of necessary resources, facilities, and special personnel to provide technical integration activities in the area of computational fluid dynamics applied to propulsion technology. Involved is the coordination of CFD activities between government, industry, and universities. Current geometry modeling, grid generation, and graphical methods are established to use in the analysis of CFD design methodologies.

The USAF Electric Propulsion Program

National Research Council Canada - National Science Library

Spores, Ronald

1999-01-01

...: Propulsion Directorate and Air Force Office of Scientific Research (AFOSR). The Propulsion Directorate conducts electric propulsion efforts in basic research, engineering development, and space experiments...

Advanced Propulsion Study

National Research Council Canada - National Science Library

Davis, Eric

2004-01-01

... that show promise of leading to a major advance in Earth-to-orbit (ETO) propulsion. The study also reviewed and evaluated a select number of credible far-term breakthrough propulsion physics concepts pertaining...

Ultrasonic propulsion of kidney stones.

Science.gov (United States)

May, Philip C; Bailey, Michael R; Harper, Jonathan D

2016-05-01

Ultrasonic propulsion is a novel technique that uses short bursts of focused ultrasonic pulses to reposition stones transcutaneously within the renal collecting system and ureter. The purpose of this review is to discuss the initial testing of effectiveness and safety, directions for refinement of technique and technology, and opinions on clinical application. Preclinical studies with a range of probes, interfaces, and outputs have demonstrated feasibility and consistent safety of ultrasonic propulsion with room for increased outputs and refinement toward specific applications. Ultrasonic propulsion was used painlessly and without adverse events to reposition stones in 14 of 15 human study participants without restrictions on patient size, stone size, or stone location. The initial feasibility study showed applicability in a range of clinically relevant situations, including facilitating passage of residual fragments following ureteroscopy or shock wave lithotripsy, moving a large stone at the ureteropelvic junction with relief of pain, and differentiating large stones from a collection of small fragments. Ultrasonic propulsion shows promise as an office-based system for transcutaneously repositioning kidney stones. Potential applications include facilitating expulsion of residual fragments following ureteroscopy or shock wave lithotripsy, repositioning stones prior to treatment, and repositioning obstructing ureteropelvic junction stones into the kidney to alleviate acute renal colic.

Component Data Base for Space Station Resistojet Auxiliary Propulsion

Science.gov (United States)

Bader, Clayton H.

1988-01-01

The resistojet was baselined for Space Station auxiliary propulsion because of its operational versatility, efficiency, and durability. This report was conceived as a guide to designers and planners of the Space Station auxiliary propulsion system. It is directed to the low thrust resistojet concept, though it should have application to other station concepts or systems such as the Environmental Control and Life Support System (ECLSS), Manufacturing and Technology Laboratory (MTL), and the Waste Fluid Management System (WFMS). The information will likely be quite useful in the same capacity for other non-Space Station systems including satellite, freeflyers, explorers, and maneuvering vehicles. The report is a catalog of the most useful information for the most significant feed system components and is organized for the greatest convenience of the user.

Liquid Rocket Engine Testing Overview

Science.gov (United States)

Rahman, Shamim

2005-01-01

Contents include the following: Objectives and motivation for testing. Technology, Research and Development Test and Evaluation (RDT&E), evolutionary. Representative Liquid Rocket Engine (LRE) test compaigns. Apollo, shuttle, Expandable Launch Vehicles (ELV) propulsion. Overview of test facilities for liquid rocket engines. Boost, upper stage (sea-level and altitude). Statistics (historical) of Liquid Rocket Engine Testing. LOX/LH, LOX/RP, other development. Test project enablers: engineering tools, operations, processes, infrastructure.

NASA's nuclear electric propulsion technology project

International Nuclear Information System (INIS)

Stone, J.R.; Sovey, J.S.

1992-07-01

The National Aeronautics and Space Administration (NASA) has initiated a program to establish the readiness of nuclear electric propulsion (NEP) technology for relatively near-term applications to outer planet robotic science missions with potential future evolution to system for piloted Mars vehicles. This program was initiated in 1991 with a very modest effort identified with nuclear thermal propulsion (NTP); however, NEP is also an integral part of this program and builds upon NASA's Base Research and Technology Program in power and electric propulsion as well as the SP-100 space nuclear power program. The NEP Program will establish the feasibility and practicality of electric propulsion for robotic and piloted solar system exploration. The performance objectives are high specific impulse (200 greater than I(sub sp) greater than 10000 s), high efficiency (over 0.50), and low specific mass. The planning for this program was initially focussed on piloted Mars missions, but has since been redirected to first focus on 100-kW class systems for relatively near-term robotic missions, with possible future evolution to megawatt-and multi-megawatt-class systems applicable to cargo vehicles supporting human missions as well as to the piloted vehicles. This paper reviews current plans and recent progress for the overall nuclear electric propulsion project and closely related activities. 33 refs

Options for development of space fission propulsion systems

International Nuclear Information System (INIS)

Houts, Mike; Van Dyke, Melissa; Godfroy, Tom; Pedersen, Kevin; Martin, James; Dickens, Ricky; Salvail, Pat; Hrbud, Ivana

2001-01-01

Fission technology can enable rapid, affordable access to any point in the solar system. Potential fission-based transportation options include high specific power continuous impulse propulsion systems and bimodal nuclear thermal rockets. Despite their tremendous potential for enhancing or enabling deep space and planetary missions, to date space fission systems have only been used in Earth orbit. The first step towards utilizing advanced fission propulsion systems is development of a safe, near-term, affordable fission system that can enhance or enable near-term missions of interest. An evolutionary approach for developing space fission propulsion systems is proposed

Comparison of Aero-Propulsive Performance Predictions for Distributed Propulsion Configurations

Science.gov (United States)

Borer, Nicholas K.; Derlaga, Joseph M.; Deere, Karen A.; Carter, Melissa B.; Viken, Sally A.; Patterson, Michael D.; Litherland, Brandon L.; Stoll, Alex M.

2017-01-01

NASA's X-57 "Maxwell" flight demonstrator incorporates distributed electric propulsion technologies in a design that will achieve a significant reduction in energy used in cruise flight. A substantial portion of these energy savings come from beneficial aerodynamic-propulsion interaction. Previous research has shown the benefits of particular instantiations of distributed propulsion, such as the use of wingtip-mounted cruise propellers and leading edge high-lift propellers. However, these benefits have not been reduced to a generalized design or analysis approach suitable for large-scale design exploration. This paper discusses the rapid, "design-order" toolchains developed to investigate the large, complex tradespace of candidate geometries for the X-57. Due to the lack of an appropriate, rigorous set of validation data, the results of these tools were compared to three different computational flow solvers for selected wing and propulsion geometries. The comparisons were conducted using a common input geometry, but otherwise different input grids and, when appropriate, different flow assumptions to bound the comparisons. The results of these studies showed that the X-57 distributed propulsion wing should be able to meet the as-designed performance in cruise flight, while also meeting or exceeding targets for high-lift generation in low-speed flight.

A comparison of propulsion systems for potential space mission applications

International Nuclear Information System (INIS)

Harvego, E.A.; Sulmeisters, T.K.

1987-01-01

A derivative of the NERVA nuclear rocket engine was compared with a chemical propulsion system and a nuclear electric propulsion system to assess the relative capabilities of the different propulsion system options for three potential space missions. The missions considered were (1) orbital transfer from low earth orbit (LEO) to geosynchronous earth orbit (GEO), (2) LEO to a lunar base, and (3) LEO to Mars. The results of this comparison indicate that the direct-thrust NERVA-derivative nuclear rocket engine has the best performance characteristics for the missions considered. The combined high thrust and high specific impulse achievable with a direct-thrust nuclear stage permits short operating times (transfer times) comparable to chemical propulsion systems, but with considerably less required propellant. While nuclear-electric propulsion systems are more fuel efficient than either direct-nuclear or chemical propulsion, they are not stand-alone systems, since their relatively low thrust levels require the use of high-thrust ferry or lander stages in high gravity applications such as surface-to-orbit propulsion. The extremely long transfer times and inefficient trajectories associated with electric propulsion systems were also found to be a significant drawback

Nuclear electric propulsion for planetary science missions: NASA technology program planning

International Nuclear Information System (INIS)

Doherty, M.P.

1993-01-01

This paper presents the status of technology program planning to achieve readiness of Nuclear Electric Propulsion technologies needed to meet the advanced propulsion system requirements for planetary science missions in the next century. The technology program planning is based upon technologies of significant maturity: ion electric propulsion and the SP-100 space nulcear power technologies. Detailed plans are presented herein for the required ion electric propulsion technology development and demonstration. Closer coordination between space nuclear power and space electric propulsion technology programs is a necessity as technology plans are being further refined in light of NEP concept definition and possible early NEP flight activities

Antimatter Requirements and Energy Costs for Near-Term Propulsion Applications

Science.gov (United States)

Schmidt, G. R.; Gerrish, H. P.; Martin, J. J.; Smith, G. A.; Meyer, K. J.

1999-01-01

The superior energy density of antimatter annihilation has often been pointed to as the ultimate source of energy for propulsion. However, the limited capacity and very low efficiency of present-day antiproton production methods suggest that antimatter may be too costly to consider for near-term propulsion applications. We address this issue by assessing the antimatter requirements for six different types of propulsion concepts, including two in which antiprotons are used to drive energy release from combined fission/fusion. These requirements are compared against the capacity of both the current antimatter production infrastructure and the improved capabilities that could exist within the early part of next century. Results show that although it may be impractical to consider systems that rely on antimatter as the sole source of propulsive energy, the requirements for propulsion based on antimatter-assisted fission/fusion do fall within projected near-term production capabilities. In fact, a new facility designed solely for antiproton production but based on existing technology could feasibly support interstellar precursor missions and omniplanetary spaceflight with antimatter costs ranging up to $6.4 million per mission.

Controllable Solid Propulsion Combustion and Acoustic Knowledge Base Improvements

Science.gov (United States)

McCauley, Rachel; Fischbach, Sean; Fredrick, Robert

2012-01-01

Controllable solid propulsion systems have distinctive combustion and acoustic environments that require enhanced testing and analysis techniques to progress this new technology from development to production. In a hot gas valve actuating system, the movement of the pintle through the hot gas exhibits complex acoustic disturbances and flow characteristics that can amplify induced pressure loads that can damage or detonate the rocket motor. The geometry of a controllable solid propulsion gas chamber can set up unique unsteady flow which can feed acoustic oscillations patterns that require characterization. Research in this area aids in the understanding of how best to design, test, and analyze future controllable solid rocket motors using the lessons learned from past government programs as well as university research and testing. This survey paper will give the reader a better understanding of the potentially amplifying affects propagated by a controllable solid rocket motor system and the knowledge of the tools current available to address these acoustic disturbances in a preliminary design. Finally the paper will supply lessons learned from past experiences which will allow the reader to come away with understanding of what steps need to be taken when developing a controllable solid rocket propulsion system. The focus of this survey will be on testing and analysis work published by solid rocket programs and from combustion and acoustic books, conference papers, journal articles, and additionally from subject matter experts dealing currently with controllable solid rocket acoustic analysis.

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia

OpenAIRE

Gregus, Ann M.; Dumlao, Darren S.; Wei, Spencer C.; Norris, Paul C.; Catella, Laura C.; Meyerstein, Flore G.; Buczynski, Matthew W.; Steinauer, Joanne J.; Fitzsimmons, Bethany L.; Yaksh, Tony L.; Dennis, Edward A.

2013-01-01

Previously, we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilins, which contribute to peripheral inflammation-induced tactile allodynia. However, the enzymatic sources of hepoxilin synthase (HXS) activity in rats remain elusive. Therefore, we overexpressed each of the 6 rat 12/15-LOX enzymes in HEK-293T cells and measured by LC-MS/MS the formation of HXB3, 12-HETE, 8-HETE, and 15-HETE from arachidonic acid (AA) at baseline and in the presenc...

A Brief Review of the Need for Robust Smart Wireless Sensor Systems for Future Propulsion Systems, Distributed Engine Controls, and Propulsion Health Management

Science.gov (United States)

Hunter, Gary W.; Behbahani, Alireza

2012-01-01

Smart Sensor Systems with wireless capability operational in high temperature, harsh environments are a significant component in enabling future propulsion systems to meet a range of increasingly demanding requirements. These propulsion systems must incorporate technology that will monitor engine component conditions, analyze the incoming data, and modify operating parameters to optimize propulsion system operations. This paper discusses the motivation towards the development of high temperature, smart wireless sensor systems that include sensors, electronics, wireless communication, and power. The challenges associated with the use of traditional wired sensor systems will be reviewed and potential advantages of Smart Sensor Systems will be discussed. A brief review of potential applications for wireless smart sensor networks and their potential impact on propulsion system operation, with emphasis on Distributed Engine Control and Propulsion Health Management, will be given. A specific example related to the development of high temperature Smart Sensor Systems based on silicon carbide electronics will be discussed. It is concluded that the development of a range of robust smart wireless sensor systems are a foundation for future development of intelligent propulsion systems with enhanced capabilities.

Development of CRTEIL and CETRIZ, Cre-loxP-Based Systems, Which Allow Change of Expression of Red to Green or Green to Red Fluorescence upon Transfection with a Cre-Expression Vector

Directory of Open Access Journals (Sweden)

Masato Ohtsuka

2009-01-01

Full Text Available We developed Cre-loxP-based systems, termed CRTEIL and CETRIZ, which allow gene switching in a noninvasive manner. Single transfection with pCRTEIL resulted in predominant expression of red fluorescence. Cotransfection with pCRTEIL and Cre-expression plasmid (pCAG/NCre caused switching from red to green fluorescence. Similarly, cotransfection with pCETRIZ and pCAG/NCre resulted in change of green to red fluorescence. These noninvasive systems will be useful in cell lineage analysis, since descendants of cells exhibiting newly activated gene expression can be continuously monitored in noninvasive fashion.

Advanced propulsion system for hybrid vehicles

Science.gov (United States)

Norrup, L. V.; Lintz, A. T.

1980-01-01

A number of hybrid propulsion systems were evaluated for application in several different vehicle sizes. A conceptual design was prepared for the most promising configuration. Various system configurations were parametrically evaluated and compared, design tradeoffs performed, and a conceptual design produced. Fifteen vehicle/propulsion systems concepts were parametrically evaluated to select two systems and one vehicle for detailed design tradeoff studies. A single hybrid propulsion system concept and vehicle (five passenger family sedan)were selected for optimization based on the results of the tradeoff studies. The final propulsion system consists of a 65 kW spark-ignition heat engine, a mechanical continuously variable traction transmission, a 20 kW permanent magnet axial-gap traction motor, a variable frequency inverter, a 386 kg lead-acid improved state-of-the-art battery, and a transaxle. The system was configured with a parallel power path between the heat engine and battery. It has two automatic operational modes: electric mode and heat engine mode. Power is always shared between the heat engine and battery during acceleration periods. In both modes, regenerative braking energy is absorbed by the battery.

Brief review on pulse laser propulsion

Science.gov (United States)

Yu, Haichao; Li, Hanyang; Wang, Yan; Cui, Lugui; Liu, Shuangqiang; Yang, Jun

2018-03-01

Pulse laser propulsion (PLP) is an advanced propulsion concept can be used across a variety of fields with a wide range of applications. PLP reflects superior payload as well as decreased launch costs in comparison with other conventional methods of producing thrust, such as chemical propulsion or electric propulsion. Numerous researchers have attempted to exploit the potential applications of PLP. This paper first reviews concepts relevant to PLP, including the propulsion modes, breakdown regimes, and propulsion efficiency; the propulsion targets for different materials with the pulse laser are then discussed in detail, including the propulsion of solid and liquid microspheres. PLP applications such as the driven microsatellite, target surface particle removal, and orbital debris removal are also discussed. Although the PLP has been applied to a variety of fields, further research is yet warranted to establish its application in the aerospace field.

NASA Electric Propulsion System Studies

Science.gov (United States)

Felder, James L.

2015-01-01

An overview of NASA efforts in the area of hybrid electric and turboelectric propulsion in large transport. This overview includes a list of reasons why we are looking at transmitting some or all of the propulsive power for the aircraft electrically, a list of the different types of hybrid-turbo electric propulsion systems, and the results of 4 aircraft studies that examined different types of hybrid-turbo electric propulsion systems.

Hybrid Propulsion Systems for Remotely Piloted Aircraft Systems

Directory of Open Access Journals (Sweden)

Mithun Abdul Sathar Eqbal

2018-03-01

Full Text Available The development of more efficient propulsion systems for aerospace vehicles is essential to achieve key objectives. These objectives are to increase efficiency while reducing the amount of carbon-based emissions. Hybrid electric propulsion (HEP is an ideal means to maintain the energy density of hydrocarbon-based fuels and utilize energy-efficient electric machines. A system that integrates different propulsion systems into a single system, with one being electric, is termed an HEP system. HEP systems have been studied previously and introduced into Land, Water, and Aerial Vehicles. This work presents research into the use of HEP systems in Remotely Piloted Aircraft Systems (RPAS. The systems discussed in this paper are Internal Combustion Engine (ICE–Electric Hybrid systems, ICE–Photovoltaic (PV Hybrid systems, and Fuel-Cell Hybrid systems. The improved performance characteristics in terms of fuel consumption and endurance are discussed.

28th Joint Propulsion Conference and Exhibit

International Nuclear Information System (INIS)

Stone, J.R.; Sovey, J.S.

1992-07-01

The National Aeronautics and Space Administration (NASA) has initiated a program to establish the readiness of nuclear electric propulsion (NEP) technology for relatively near-term applications to outer planet robotic science missions with potential future evolution to system for piloted Mars vehicles. This program was initiated in 1991 with a very modest effort identified with nuclear thermal propulsion (NTP); however, NEP is also an integral part of this program and builds upon NASA's Base Research and Technology Program in power and electric propulsion as well as the SP-100 space nuclear power program. The NEP Program will establish the feasibility and practicality of electric propulsion for robotic and piloted solar system exploration. The performance objectives are high specific impulse (200 greater than I(sub sp) greater than 10000 s), high efficiency (over 0.50), and low specific mass. The planning for this program was initially focussed on piloted Mars missions, but has since been redirected to first focus on 100-kW class systems for relatively near-term robotic missions, with possible future evolution to megawatt- and multi-megawatt-class systems applicable to cargo vehicles supporting human missions as well as to the piloted vehicles. This paper reviews current plans and recent progress for the overall nuclear electric propulsion project and closely related activities

Project ARGO: The design and analysis of an all-propulsive and an aeroassisted version of a manned space transportation vehicle

Science.gov (United States)

Wang, H.; Seifert, D.; Waidelich, J.; Mileski, M.; Herr, D.; Wilks, M.; Law, G.; Folz, A.

1989-01-01

The Senior Aerospace System Design class at the University of Michigan undertook the design of a manned space transportation vehicle (STV) that would transport payloads between low earth orbit (LEO) and geosynchronous earth orbit (GEO). Designated ARGO after the ship of the Greek adventurer Jason, two different versions of an STV that would be based, refueled, and serviced at the Space Station Freedom were designed and analyzed by the class. With the same 2-man/7-day nominal mission of transporting a 10,000-kg payload up to GEO and bringing a 5000-kg payload back to LEO, the two versions of ARGO differ in the manner in which the delta V is applied to insert the vehicle into LEO upon return from GEO. The all-propulsive ARGO (or CSTV for chemical STV) uses thrust from its LH2/LOX rocket engines to produce the delta V during all phases of its mission. While the aeroassisted ARGO (or ASTV for aeroassisted STV) also uses the same engines for the majority of the mission, the final delta V used to insert the ASTV into LEO is produced by skimming the Earth's atmosphere and using the drag on the vehicle to apply the required delta V. This procedure allows for large propellant, and thus cost, savings, but creates many design problems such as the high heating rates and decelerations experienced by a vehicle moving through the atmosphere at hypersonic velocities. The design class, consisting of 43 senior aerospace engineering students, was divided into one managerial and eight technical groups. The technical groups consisted of spacecraft configuration and integration, mission analysis, atmospheric flight, propulsion, power and communications, life support and human factors, logistics and support, and systems analysis. Two committees were set up with members from each group to create the scale models of the STV's and to produce the final report.

Optimum cycle frequencies in hand-rim wheelchair propulsion. Wheelchair propulsion technique

NARCIS (Netherlands)

van der Woude, L H; Veeger, DirkJan (H. E. J.); Rozendal, R H; Sargeant, A J

1989-01-01

To study the effect of different cycle frequencies on cardio-respiratory responses and propulsion technique in hand-rim wheelchair propulsion, experienced wheelchair sportsmen (WS group; n = 6) and non-wheelchair users (NW group; n = 6) performed wheelchair exercise tests on a motor-driven

Effect of workload setting on propulsion technique in handrim wheelchair propulsion

NARCIS (Netherlands)

van Drongelen, Stefan; Arnet, Ursina; Veeger, DirkJan (H E. J); van der Woude, Lucas H. V.

Objective: To investigate the influence of workload setting (speed at constant power, method to impose power) on the propulsion technique (i.e. force and timing characteristics) in handrim wheelchair propulsion. Method: Twelve able-bodied men participated in this study. External forces were measured

Critical Propulsion Components. Volume 1; Summary, Introduction, and Propulsion Systems Studies

Science.gov (United States)

2005-01-01

Several studies have concluded that a supersonic aircraft, if environmentally acceptable and economically viable, could successfully compete in the 21st century marketplace. However, before industry can commit to what is estimated as a 15 to 20 billion dollar investment, several barrier issues must be resolved. In an effort to address these barrier issues, NASA and Industry teamed to form the High-Speed Research (HSR) program. As part of this program, the Critical Propulsion Components (CPC) element was created and assigned the task of developing those propulsion component technologies necessary to: (1) reduce cruise emissions by a factor of 10 and (2) meet the ever-increasing airport noise restrictions with an economically viable propulsion system. The CPC-identified critical components were ultra-low emission combustors, low-noise/high-performance exhaust nozzles, low-noise fans, and stable/high-performance inlets. Propulsion cycle studies (coordinated with NASA Langley Research Center sponsored airplane studies) were conducted throughout this CPC program to help evaluate candidate components and select the best concepts for the more complex and larger scale research efforts. The propulsion cycle and components ultimately selected were a mixed-flow turbofan (MFTF) engine employing a lean, premixed, prevaporized (LPP) combustor coupled to a two-dimensional mixed compression inlet and a two-dimensional mixer/ejector nozzle. Due to the large amount of material presented in this report, it was prepared in four volumes; Volume 1: Summary, Introduction, and Propulsion System Studies, Volume 2: Combustor, Volume 3: Exhaust Nozzle, and Volume 4: Inlet and Fan/ Inlet Acoustic Team.

Propulsive efficiency of a biomorphic pulsed-jet underwater vehicle

International Nuclear Information System (INIS)

Moslemi, Ali A; Krueger, Paul S

2010-01-01

The effect of the velocity program and duty cycle (St L ) on the propulsive efficiency of pulsed-jet propulsion was studied experimentally on a self-propelled, pulsed-jet underwater vehicle, dubbed Robosquid due to the similarity of essential elements of its propulsion system with squid jet propulsion. Robosquid was tested for jet slug length-to-diameter ratios (L/D) in the range 2-6 and St L in the range 0.2-0.6 with jet velocity programs commanded to be triangular or trapezoidal. Digital particle image velocimetry was used for measuring the impulse and energy of jet pulses to calculate the pulsed-jet propulsive efficiency and compare it with an equivalent steady jet system. Robosquid's Reynolds number (Re) based on average vehicle velocity and vehicle diameter ranged between 1300 and 2700 for the conditions tested. The results indicated better propulsive efficiency of the trapezoidal velocity program (up to 20% higher) compared to the triangular velocity program. Also, an increase in the ratio of the pulsed-jet propulsive efficiency to the equivalent steady jet propulsive efficiency (η P /η P,ss ) was observed as St L increased and L/D decreased. For cases of short L/D and high St L , η P /η P,ss was found to be as high as 1.2, indicating better performance of pulsed jets. This result demonstrates a case where propulsion using essential elements of a biological locomotion system can outperform the traditional mechanical system equivalent in terms of efficiency. It was also found that changes in St L had a proportionately larger effect on propulsive efficiency compared to changes in L/D. A simple model is presented to explain the results in terms of the contribution of over-pressure at the nozzle exit plane associated with the formation of vortex rings with each jet pulse.

Cre/lox system to develop selectable marker free transgenic tobacco plants conferring resistance against sap sucking homopteran insect.

Science.gov (United States)

Chakraborti, Dipankar; Sarkar, Anindya; Mondal, Hossain A; Schuermann, David; Hohn, Barbara; Sarmah, Bidyut K; Das, Sampa

2008-10-01

A binary expression vector was constructed containing the insecticidal gene Allium sativum leaf agglutinin (ASAL), and a selectable nptII marker gene cassette, flanked by lox sites. Similarly, another binary vector was developed with the chimeric cre gene construct. Transformed tobacco plants were generated with these two independent vectors. Each of the T(0) lox plants was crossed with T(0) Cre plants. PCR analyses followed by the sequencing of the target T-DNA part of the hybrid T(1) plants demonstrated the excision of the nptII gene in highly precised manner in certain percentage of the T(1) hybrid lines. The frequency of such marker gene excision was calculated to be 19.2% in the hybrids. Marker free plants were able to express ASAL efficiently and reduce the survivability of Myzus persiceae, the deadly pest of tobacco significantly, compared to the control tobacco plants. Results of PCR and Southern blot analyses of some of the T(2) plants detected the absence of cre as well as nptII genes. Thus, the crossing strategy involving Cre/lox system for the excision of marker genes appears to be very effective and easy to execute. Documentation of such marker excision phenomenon in the transgenic plants expressing the important insecticidal protein for the first time has a great significance from agricultural and biotechnological points of view.

Electric vehicle propulsion alternatives

Science.gov (United States)

Secunde, R. R.; Schuh, R. M.; Beach, R. F.

1983-01-01

Propulsion technology development for electric vehicles is summarized. Analytical studies, technology evaluation, and the development of technology for motors, controllers, transmissions, and complete propulsion systems are included.

Fuel Effective Photonic Propulsion

Science.gov (United States)

Rajalakshmi, N.; Srivarshini, S.

2017-09-01

With the entry of miniaturization in electronics and ultra-small light-weight materials, energy efficient propulsion techniques for space travel can soon be possible. We need to go for such high speeds so that the generation’s time long interstellar missions can be done in incredibly short time. Also renewable energy like sunlight, nuclear energy can be used for propulsion instead of fuel. These propulsion techniques are being worked on currently. The recently proposed photon propulsion concepts are reviewed, that utilize momentum of photons generated by sunlight or onboard photon generators, such as blackbody radiation or lasers, powered by nuclear or solar power. With the understanding of nuclear photonic propulsion, in this paper, a rough estimate of nuclear fuel required to achieve the escape velocity of Earth is done. An overview of the IKAROS space mission for interplanetary travel by JAXA, that was successful in demonstrating that photonic propulsion works and also generated additional solar power on board, is provided; which can be used as a case study. An extension of this idea for interstellar travel, termed as ‘Star Shot’, aims to send a nanocraft to an exoplanet in the nearest star system, which could be potentially habitable. A brief overview of the idea is presented.

Numerical Propulsion System Simulation (NPSS): An Award Winning Propulsion System Simulation Tool

Science.gov (United States)

Stauber, Laurel J.; Naiman, Cynthia G.

2002-01-01

The Numerical Propulsion System Simulation (NPSS) is a full propulsion system simulation tool used by aerospace engineers to predict and analyze the aerothermodynamic behavior of commercial jet aircraft, military applications, and space transportation. The NPSS framework was developed to support aerospace, but other applications are already leveraging the initial capabilities, such as aviation safety, ground-based power, and alternative energy conversion devices such as fuel cells. By using the framework and developing the necessary components, future applications that NPSS could support include nuclear power, water treatment, biomedicine, chemical processing, and marine propulsion. NPSS will dramatically reduce the time, effort, and expense necessary to design and test jet engines. It accomplishes that by generating sophisticated computer simulations of an aerospace object or system, thus enabling engineers to "test" various design options without having to conduct costly, time-consuming real-life tests. The ultimate goal of NPSS is to create a numerical "test cell" that enables engineers to create complete engine simulations overnight on cost-effective computing platforms. Using NPSS, engine designers will be able to analyze different parts of the engine simultaneously, perform different types of analysis simultaneously (e.g., aerodynamic and structural), and perform analysis in a more efficient and less costly manner. NPSS will cut the development time of a new engine in half, from 10 years to 5 years. And NPSS will have a similar effect on the cost of development: new jet engines will cost about a billion dollars to develop rather than two billion. NPSS is also being applied to the development of space transportation technologies, and it is expected that similar efficiencies and cost savings will result. Advancements of NPSS in fiscal year 2001 included enhancing the NPSS Developer's Kit to easily integrate external components of varying fidelities, providing

In-Space Propulsion Technology Program Solar Electric Propulsion Technologies

Science.gov (United States)

Dankanich, John W.

2006-01-01

NASA's In-space Propulsion (ISP) Technology Project is developing new propulsion technologies that can enable or enhance near and mid-term NASA science missions. The Solar Electric Propulsion (SEP) technology area has been investing in NASA s Evolutionary Xenon Thruster (NEXT), the High Voltage Hall Accelerator (HiVHAC), lightweight reliable feed systems, wear testing, and thruster modeling. These investments are specifically targeted to increase planetary science payload capability, expand the envelope of planetary science destinations, and significantly reduce the travel times, risk, and cost of NASA planetary science missions. Status and expected capabilities of the SEP technologies are reviewed in this presentation. The SEP technology area supports numerous mission studies and architecture analyses to determine which investments will give the greatest benefit to science missions. Both the NEXT and HiVHAC thrusters have modified their nominal throttle tables to better utilize diminished solar array power on outbound missions. A new life extension mechanism has been implemented on HiVHAC to increase the throughput capability on low-power systems to meet the needs of cost-capped missions. Lower complexity, more reliable feed system components common to all electric propulsion (EP) systems are being developed. ISP has also leveraged commercial investments to further validate new ion and hall thruster technologies and to potentially lower EP mission costs.

Modeling of Ship Propulsion Performance

DEFF Research Database (Denmark)

Pedersen, Benjamin Pjedsted; Larsen, Jan

2009-01-01

Full scale measurements of the propulsion power, ship speed, wind speed and direction, sea and air temperature, from four different loading conditions has been used to train a neural network for prediction of propulsion power. The network was able to predict the propulsion power with accuracy...

Three-Dimensional Numerical Analysis of LOX/Kerosene Engine Exhaust Plume Flow Field Characteristics

Directory of Open Access Journals (Sweden)

Hong-hua Cai

2017-01-01

Full Text Available Aiming at calculating and studying the flow field characteristics of engine exhaust plume and comparative analyzing the effects of different chemical reaction mechanisms on the engine exhaust plume flow field characteristics, a method considering fully the combustion state influence is put forward, which is applied to exhaust plume flow field calculation of multinozzle engine. On this basis, a three-dimensional numerical analysis of the effects of different chemical reaction mechanisms on LOX/kerosene engine exhaust plume flow field characteristics was carried out. It is found that multistep chemical reaction can accurately describe the combustion process in the LOX/kerosene engine, the average chamber pressure from the calculation is 4.63% greater than that of the test, and the average chamber temperature from the calculation is 3.34% greater than that from the thermodynamic calculation. The exhaust plumes of single nozzle and double nozzle calculated using the global chemical reaction are longer than those using the multistep chemical reaction; the highest temperature and the highest velocity on the plume axis calculated using the former are greater than that using the latter. The important influence of chemical reaction mechanism must be considered in the study of the fixing structure of double nozzle engine on the rocket body.

Theoretical Acoustic Absorber Design Approach for LOX/LCH4 Pintle Injector Rocket Engines

Science.gov (United States)

Candelaria, Jonathan

Liquid rocket engines, or LREs, have served a key role in space exploration efforts. One current effort involves the utilization of liquid oxygen (LOX) and liquid methane (LCH4) LREs to explore Mars with in-situ resource utilization for propellant production. This on-site production of propellant will allow for greater payload allocation instead of fuel to travel to the Mars surface, and refueling of propellants to travel back to Earth. More useable mass yields a greater benefit to cost ratio. The University of Texas at El Paso's (UTEP) Center for Space Exploration and Technology Research Center (cSETR) aims to further advance these methane propulsion systems with the development of two liquid methane - liquid oxygen propellant combination rocket engines. The design of rocket engines, specifically liquid rocket engines, is complex in that many variables are present that must be taken into consideration in the design. A problem that occurs in almost every rocket engine development program is combustion instability, or oscillatory combustion. It can result in the destruction of the rocket, subsequent destruction of the vehicle and compromise the mission. These combustion oscillations can vary in frequency from 100 to 20,000 Hz or more, with varying effects, and occur from different coupling phenomena. It is important to understand the effects of combustion instability, its physical manifestations, how to identify the instabilities, and how to mitigate or dampen them. Linear theory methods have been developed to provide a mathematical understanding of the low- to mid-range instabilities. Nonlinear theory is more complex and difficult to analyze mathematically, therefore no general analytical method that yields a solution exists. With limited resources, time, and the advice of our NASA mentors, a data driven experimental approach utilizing quarter wave acoustic dampener cavities was designed. This thesis outlines the methodology behind the design of an acoustic

Regional gene expression of LOX-1, VCAM-1, and ICAM-1 in aorta of HIV-1 transgenic rats

DEFF Research Database (Denmark)

Hag, Anne Mette Fisker; Kristoffersen, Ulrik Sloth; Pedersen, Sune Folke

2009-01-01

endpoints, studies in animal models could be attractive alternatives. METHODOLOGY/PRINCIPAL FINDINGS: We evaluated gene expression of lectin-like oxidized-low-density-lipoprotein receptor-1 (LOX-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in HIV-1...... transgenic (HIV-1Tg) rats; these genes are all thought to play important roles in early atherogenesis. Furthermore, the plasma level of sICAM-1 was measured. We found that gene expressions of LOX-1 and VCAM-1 were higher in the aortic arch of HIV-1Tg rats compared to controls. Also, the level of sICAM-1......-infection per se may cause atherosclerosis. This transgenic rat model may be a very promising model for further studies of the pathophysiology behind HIV-associated cardiovascular disease....

LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies

Science.gov (United States)

Rizzacasa, Barbara; Morini, Elena; Pucci, Sabina; Murdocca, Michela; Novelli, Giuseppe; Amati, Francesca

2017-01-01

Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA) splicing sites are differentially selected to diversify the protein isoform population. Changes in AS patterns have an essential role in normal development, differentiation and response to physiological stimuli. It is documented that AS can generate both “risk” and “protective” splice variants that can contribute to the pathogenesis of several diseases including atherosclerosis. The main endothelial receptor for oxidized low-density lipoprotein (ox-LDLs) is LOX-1 receptor protein encoded by the OLR1 gene. When OLR1 undergoes AS events, it generates three variants: OLR1, OLR1D4 and LOXIN. The latter lacks exon 5 and two-thirds of the functional domain. Literature data demonstrate a protective role of LOXIN in pathologies correlated with LOX-1 overexpression such as atherosclerosis and tumors. In this review, we summarize recent developments in understanding of OLR1 AS while also highlighting data warranting further investigation of this process as a novel therapeutic target. PMID:28146073

Maturing the M10A 25,000lbf Liquid Oxygen/Methane Broadsword Engine

Data.gov (United States)

National Aeronautics and Space Administration — Masten’s effort will advance development of a full-scale additive manufactured aluminum thrust chamber assembly for a 25,000 lbf LOX/LCH4 dual expander propulsion...

Wheelchairs propulsion analysis: review

Directory of Open Access Journals (Sweden)

Yoshimasa Sagawa Júnior

Full Text Available OBJECTIVES: To analyze aspects related with wheelchair propulsion. MATERIALS AND METHODS: In order to delineate this review the search for information was carried out within electronics databases, using the following descriptors: "wheelchair propulsion", "wheelchair biomechanics" e "wheelchair users". Full papers published in English and French were included in the study. RESULTS: The wheelchair propulsion is a complex movement that requires the execution of repeated bi manual forces applications during a short time period. In this movement high levels of force must be produced due to the bad mechanical performance of the wheelchair. Could be characterized that wheelchair users are not satisfied with their wheelchair, the places are not adapted to their presence and lack of specific criteria for the adjustment of this equipment. The main points to look at are the seat height in relation to elbow flexion (100-120 degrees with his hand in the propulsion rim and tire pressure. The semicircular mode of technique propulsion seems to be more appropriate; in this pattern the wheelchair user returns his hand under the rim after propulsion. Efforts in wheelchairs are high and the incidence of injuries in wheelchair users is high. CONCLUSION: One can conclude that in spite of researchers’ efforts there are still many divergences between topics and methods of evaluation, what makes difficult to apply the experimental results to the wheelchairs users’ daily life.

Ion Beam Propulsion Study

Science.gov (United States)

2008-01-01

The Ion Beam Propulsion Study was a joint high-level study between the Applied Physics Laboratory operated by NASA and ASRC Aerospace at Kennedy Space Center, Florida, and Berkeley Scientific, Berkeley, California. The results were promising and suggested that work should continue if future funding becomes available. The application of ion thrusters for spacecraft propulsion is limited to quite modest ion sources with similarly modest ion beam parameters because of the mass penalty associated with the ion source and its power supply system. Also, the ion source technology has not been able to provide very high-power ion beams. Small ion beam propulsion systems were used with considerable success. Ion propulsion systems brought into practice use an onboard ion source to form an energetic ion beam, typically Xe+ ions, as the propellant. Such systems were used for steering and correction of telecommunication satellites and as the main thruster for the Deep Space 1 demonstration mission. In recent years, "giant" ion sources were developed for the controlled-fusion research effort worldwide, with beam parameters many orders of magnitude greater than the tiny ones of conventional space thruster application. The advent of such huge ion beam sources and the need for advanced propulsion systems for exploration of the solar system suggest a fresh look at ion beam propulsion, now with the giant fusion sources in mind.

Nuclear propulsion systems for orbit transfer based on the particle bed reactor

International Nuclear Information System (INIS)

Powell, J.R.; Ludewig, H.; Horn, F.L.

1987-01-01

The technology of nuclear direct propulsion orbit transfer systems based on the Particle Bed Reactor (PBR) is described. A 200 megawatt illustrative design is presented for LEO to GEO and other high ΔV missions. The PBR-NOTV can be used in a one-way mode with the shuttle or an expendable launch vehicle, e.g., the Titan 34D7, or as a two-way reusable space tug. In the one-way mode, payload capacity is almost three times greater than that of chemical OTV's. PBR technology status is described and development needs outlined

Development costs for a nuclear electric propulsion stage.

Science.gov (United States)

Mondt, J. F.; Prickett, W. Z.

1973-01-01

Development costs are presented for an unmanned nuclear electric propulsion (NEP) stage based upon a liquid metal cooled, in-core thermionic reactor. A total of 120 kWe are delivered to the thrust subsystem which employs mercury ion engines for electric propulsion. This study represents the most recent cost evaluation of the development of a reactor power system for a wide range of nuclear space power applications. These include geocentric, and outer planet and other deep space missions. The development program is described for the total NEP stage, based upon specific development programs for key NEP stage components and subsystems.

A propulsion technology challenge — An abortable. Continuous use vehicle

Science.gov (United States)

Czysz, Paul A.; Froning, H. David

1996-02-01

Propulsion is the enabling technology for an abortable, continuous use vehicle. Propulsion performance purchases margin in the other material, structural, and system requirements. But what is abortability, and continuous use? Why is it necessary? What are its characteristics? And, what specifically is required in the propulsion system to enable these characteristics? Is the cost of the launcher really trivial, or is that the incomplete cost analysis limited to expendables and rebuilt, reusables. This paper identifies what constitutes an abortable, continuous use vehicle, the propulsion characteristics required, and the technology necessary to provide those characteristics. The proposition resulting is that this is not a technology issue, it is a concept of operation and a bureaucratic issue. The required goal is not as distant as some might propose, and the technology not as unprepared for commercial application as some assumed. The conclusion is that clearly we cannot continue to base the next century's orbital operations on an expendable rebuilt for reuse concept. What is required is a rocket based combined cycle (RBCC) engine based on those now in space operation 1,2; not a combination of cycles that remains to be shown as a practical, achievable reality.

Computational Fluid Dynamics (CFD) applications in rocket propulsion analysis and design

Science.gov (United States)

Mcconnaughey, P. K.; Garcia, R.; Griffin, L. W.; Ruf, J. H.

1993-01-01

Computational Fluid Dynamics (CFD) has been used in recent applications to affect subcomponent designs in liquid propulsion rocket engines. This paper elucidates three such applications for turbine stage, pump stage, and combustor chamber geometries. Details of these applications include the development of a high turning airfoil for a gas generator (GG) powered, liquid oxygen (LOX) turbopump, single-stage turbine using CFD as an integral part of the design process. CFD application to pump stage design has emphasized analysis of inducers, impellers, and diffuser/volute sections. Improvements in pump stage impeller discharge flow uniformity have been seen through CFD optimization on coarse grid models. In the area of combustor design, recent CFD analysis of a film cooled ablating combustion chamber has been used to quantify the interaction between film cooling rate, chamber wall contraction angle, and geometry and their effects of these quantities on local wall temperature. The results are currently guiding combustion chamber design and coolant flow rate for an upcoming subcomponent test. Critical aspects of successful integration of CFD into the design cycle includes a close-coupling of CFD and design organizations, quick turnaround of parametric analyses once a baseline CFD benchmark has been established, and the use of CFD methodology and approaches that address pertinent design issues. In this latter area, some problem details can be simplified while retaining key physical aspects to maintain analytical integrity.

Performance Criteria of Nuclear Space Propulsion Systems

Science.gov (United States)

Shepherd, L. R.

Future exploration of the solar system on a major scale will require propulsion systems capable of performance far greater than is achievable with the present generation of rocket engines using chemical propellants. Viable missions going deeper into interstellar space will be even more demanding. Propulsion systems based on nuclear energy sources, fission or (eventually) fusion offer the best prospect for meeting the requirements. The most obvious gain coming from the application of nuclear reactions is the possibility, at least in principle, of obtaining specific impulses a thousandfold greater than can be achieved in chemically energised rockets. However, practical considerations preclude the possibility of exploiting the full potential of nuclear energy sources in any engines conceivable in terms of presently known technology. Achievable propulsive power is a particularly limiting factor, since this determines the acceleration that may be obtained. Conventional chemical rocket engines have specific propulsive powers (power per unit engine mass) in the order of gigawatts per tonne. One cannot envisage the possibility of approaching such a level of performance by orders of magnitude in presently conceivable nuclear propulsive systems. The time taken, under power, to reach a given terminal velocity is proportional to the square of the engine's exhaust velocity and the inverse of its specific power. An assessment of various nuclear propulsion concepts suggests that, even with the most optimistic assumptions, it could take many hundreds of years to attain the velocities necessary to reach the nearest stars. Exploration within a range of the order of a thousand AU, however, would appear to offer viable prospects, even with the low levels of specific power of presently conceivable nuclear engines.

Space transportation propulsion USSR launcher technology, 1990

Science.gov (United States)

1991-01-01

Space transportation propulsion U.S.S.R. launcher technology is discussed. The following subject areas are covered: Energia background (launch vehicle summary, Soviet launcher family) and Energia propulsion characteristics (booster propulsion, core propulsion, and growth capability).

Conditional and inducible transgene expression in endothelial and hematopoietic cells using Cre/loxP and tetracycline-off systems.

Science.gov (United States)

Liu, Ju; Deutsch, Urban; Fung, Iris; Lobe, Corrinne G

2014-11-01

In the present study, the tetracycline-off and Cre/ loxP systems were combined to gain temporal and spatial control of transgene expression. Mice were generated that carried three transgenes: Tie2-tTA, tet-O-Cre and either the ZEG or ZAP reporter. Tie2-tTA directs expression of tetracycline-controlled transactivator (tTA) in endothelial and hematopoietic cells under the control of the Tie2 promoter. Tet-O-Cre produces Cre recombinase from a minimal promoter containing the tet-operator (tetO). ZEG or ZAP contains a strong promoter and a loxP -flanked stop sequence, followed by an enhanced green fluorescence protein (EGFP) or human placental alkaline phosphatase (hPLAP) reporter. In the presence of tetracycline, the tTA transactivator produced by Tie-2-tTA is disabled and Cre is not expressed. In the absence of tetracycline, the tTA binds tet-O-Cre to drive the expression of Cre, which recombines the loxP sites of the ZEG or ZAP transgene and results in reporter gene expression. In the present study, the expression of the ZEG or ZAP reporter genes in embryos and adult animals with and without tetracycline treatment was examined. In the presence of tetracycline, no reporter gene expression was observed. When tetracycline was withdrawn, Cre excision was activated and the reporter genes were detected in endothelial and hematopoietic cells. These results demonstrate that this system may be used to bypass embryonic lethality and access adult phenotypes.

Planetary explorer liquid propulsion study

Science.gov (United States)

Mckevitt, F. X.; Eggers, R. F.; Bolz, C. W.

1971-01-01

An analytical evaluation of several candidate monopropellant hydrazine propulsion system approaches is conducted in order to define the most suitable configuration for the combined velocity and attitude control system for the Planetary Explorer spacecraft. Both orbiter and probe-type missions to the planet Venus are considered. The spacecraft concept is that of a Delta launched spin-stabilized vehicle. Velocity control is obtained through preprogrammed pulse-mode firing of the thrusters in synchronism with the spacecraft spin rate. Configuration selection is found to be strongly influenced by the possible error torques induced by uncertainties in thruster operation and installation. The propulsion systems defined are based on maximum use of existing, qualified components. Ground support equipment requirements are defined and system development testing outlined.

Reactors for nuclear electric propulsion

Energy Technology Data Exchange (ETDEWEB)

Buden, D.; Angelo, J.A. Jr.

1981-01-01

Propulsion is the key to space exploitation and power is the key to propulsion. This paper examines the role of nuclear fission reactors as the primary power source for high specific impulse electric propulsion systems for space missions of the 1980s and 1990s. Particular mission applications include transfer to and a reusable orbital transfer vehicle from low-Earth orbit to geosynchronous orbit, outer planet exploration and reconnaissance missions, and as a versatile space tug supporting lunar resource development. Nuclear electric propulsion is examined as an indispensable component in space activities of the next two decades.

Reactors for nuclear electric propulsion

International Nuclear Information System (INIS)

Buden, D.; Angelo, J.A. Jr.

1981-01-01

Propulsion is the key to space exploitation and power is the key to propulsion. This paper examines the role of nuclear fission reactors as the primary power source for high specific impulse electric propulsion systems for space missions of the 1980s and 1990s. Particular mission applications include transfer to and a reusable orbital transfer vehicle from low-Earth orbit to geosynchronous orbit, outer planet exploration and reconnaissance missions, and as a versatile space tug supporting lunar resource development. Nuclear electric propulsion is examined as an indispensable component in space activities of the next two decades

Prediction of applied forces in handrim wheelchair propulsion.

Science.gov (United States)

Lin, Chien-Ju; Lin, Po-Chou; Guo, Lan-Yuen; Su, Fong-Chin

2011-02-03

Researchers of wheelchair propulsion have usually suggested that a wheelchair can be properly designed using anthropometrics to reduce high mechanical load and thus reduce pain and damage to joints. A model based on physiological features and biomechanical principles can be used to determine anthropometric relationships for wheelchair fitting. To improve the understanding of man-machine interaction and the mechanism through which propulsion performance been enhanced, this study develops and validates an energy model for wheelchair propulsion. Kinematic data obtained from ten able-bodied and ten wheelchair-dependent users during level propulsion at an average velocity of 1m/s were used as the input of a planar model with the criteria of increasing efficiency and reducing joint load. Results demonstrate that for both experienced and inexperienced users, predicted handrim contact forces agree with experimental data through an extensive range of the push. Significant deviations that were mostly observed in the early stage of the push phase might result from the lack of consideration of muscle dynamics and wrist joint biomechanics. The proposed model effectively verified the handrim contact force patterns during dynamic propulsion. Users do not aim to generate mechanically most effective forces to avoid high loadings on the joints. Copyright © 2010 Elsevier Ltd. All rights reserved.

Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP

OpenAIRE

Cox, Brandon C.; Liu, Zhiyong; Lagarde, Marcia M. Mellado; Zuo, Jian

2012-01-01

In recent years, there has been significant progress in the use of Cre-loxP technology for conditional gene expression in the inner ear. Here, we introduce the basic concepts of this powerful technology, emphasizing the differences between Cre and CreER. We describe the creation and Cre expression pattern of each Cre and CreER mouse line that has been reported to have expression in auditory and vestibular organs. We compare the Cre expression patterns between Atoh1-CreERTM and Atoh1-CreERT2 a...

Additive Manufacturing of Aerospace Propulsion Components

Science.gov (United States)

Misra, Ajay K.; Grady, Joseph E.; Carter, Robert

2015-01-01

The presentation will provide an overview of ongoing activities on additive manufacturing of aerospace propulsion components, which included rocket propulsion and gas turbine engines. Future opportunities on additive manufacturing of hybrid electric propulsion components will be discussed.

Using Additive Manufacturing to Print a CubeSat Propulsion System

Science.gov (United States)

Marshall, William M.

2015-01-01

CubeSats are increasingly being utilized for missions traditionally ascribed to larger satellites CubeSat unit (1U) defined as 10 cm x 10 cm x 11 cm. Have been built up to 6U sizes. CubeSats are typically built up from commercially available off-the-shelf components, but have limited capabilities. By using additive manufacturing, mission specific capabilities (such as propulsion), can be built into a system. This effort is part of STMD Small Satellite program Printing the Complete CubeSat. Interest in propulsion concepts for CubeSats is rapidly gaining interest-Numerous concepts exist for CubeSat scale propulsion concepts. The focus of this effort is how to incorporate into structure using additive manufacturing. End-use of propulsion system dictates which type of system to develop-Pulse-mode RCS would require different system than a delta-V orbital maneuvering system. Team chose an RCS system based on available propulsion systems and feasibility of printing using a materials extrusion process. Initially investigated a cold-gas propulsion system for RCS applications-Materials extrusion process did not permit adequate sealing of part to make this a functional approach.

Development of superconducting ship propulsion system

International Nuclear Information System (INIS)

Sakuraba, Junji; Mori, Hiroyuki; Hata, Fumiaki; Sotooka, Koukichi

1991-01-01

When we plan displacement-type monohull high speed vessels, it is difficult to get the hull form with the wave-making resistance minimum, because the stern shape is restricted by arrangement of propulsive machines and shafts. A small-sized and light-weight propulsive machines will reduce the limit to full form design. Superconducting technology will have capability of realizing the small-sized and light-weight propulsion motor. The superconducting electric propulsion system which is composed of superconducting propulsion motors and generators, seems to be an ideal propulsion system for future vehicles. We have constructed a 480 kW superconducting DC homopolar laboratory test motor for developing this propulsion system. The characteristic of this motor is that it has a superconducting field winding and a segmented armature drum. The superconducting field winding which operates in the persistent current mode, is cooled by a condensation heat exchanger and helium refigerating system built into the cryostat of the superconducting field winding. The operating parameters of this motor agreed well with the design parameters. Using the design concepts of this motor, we have conceptually designed a 150,000-200,000 PS superconducting electric propulsive system for a displacement-type monohull high speed ship. (author)

Fusion propulsion systems

International Nuclear Information System (INIS)

Haloulakos, V.E.; Bourque, R.F.

1989-01-01

The continuing and expanding national efforts in both the military and commercial sectors for exploration and utilization of space will require launch, assembly in space, and orbital transfer of large payloads. The currently available delivery systems, utilizing various forms of chemical propulsion, do not have the payload capacity to fulfill the planned missions. National planning documents such as Air Force Project Forecast II and the National Commission on Space Report to the President contain numerous missions and payload delivery schedules that are beyond the present capabilities of the available systems, such as the Space Shuttle and the Expendable Launch Vehicles (ELVs). The need, therefore, is very pressing to design, develop, and deploy propulsion systems that offer a quantum level increase in delivered performance. One such potential system is fusion propulsion. This paper summarizes the result of an Air Force Astronautics Laboratory (AFAL) sponsored study of fusion propulsion conducted by the McDonnell Douglas Astronautics Company (MDAC), and its subcontractor General Atomics This study explored the potential of fusion propulsion for Air Force missions. Fusion fuels and existing confinement concepts were evaluated according to elaborate criteria. Two fuels, deuterium-tritium and deuterium-helium 3 (D- 3 He) were considered worthy of further consideration. D- 3 He was selected as the most attractive for this Air Force study. The colliding translating compact torus confinement concept was evaluated in depth and found to possibly possess the low mass and compactness required. Another possible concept is inertial confinement with the propellant surrounding the target. 5 refs., 5 figs., 8 tabs

Cold inducible promoter driven Cre-lox system proved to be highly efficient for marker gene excision in transgenic barley.

Science.gov (United States)

Éva, Csaba; Téglás, Flóra; Zelenyánszki, Helga; Tamás, Cecília; Juhász, Angéla; Mészáros, Klára; Tamás, László

2018-01-10

A Cre-lox based auto-excision strategy has been adapted for barley, capable of cre and selectable marker gene (SMG) removal. The cold inducible wheat promoter called wcs120 was utilised for driving Cre expression. The binary vector was carrying the transgene (uidA) and a so called 'recombination cassette' flanked by the lox sequences. This part included both the recombinase gene and the SMG (bar) under the control of a constitutive promoter. T 0 , T 1 and T 2 transgenic plants were subjected to low temperature (at 4°C, 10°C and 12°C) at different developmental stages to induce recombination. The presence of uidA, cre, and bar genes and recombination footprints were studied by PCR and DNA sequencing, while cre transcription was followed by qRT-PCR. These analyses indicated that, cold treatment of the germinating seeds (4°C for 3days) followed by plant growing at higher temperature (24°C) has been the most efficient (90-100%), and this treatment lead to heritable changes in the genome. Thermal separation of Cre accumulation (at low temperature) from Cre enzyme activity (at higher temperature) could have prevented the premature excision of its own encoding gene, and lead to high expression level thereby increasing recombination frequency. Copyright © 2017 Elsevier B.V. All rights reserved.

Cold Gas Micro Propulsion

NARCIS (Netherlands)

Louwerse, M.C.

2009-01-01

This thesis describes the development of a micro propulsion system. The trend of miniaturization of satellites requires small sized propulsion systems. For particular missions it is important to maintain an accurate distance between multiple satellites. Satellites drift apart due to differences in

Efecto in vitro del D-002 sobre la actividad enzimática de la 5-lipoxigenasa (5-LOX

Directory of Open Access Journals (Sweden)

Yohani Pérez Guerra

2012-06-01

Full Text Available Introducción: el D-002, mezcla de seis alcoholes alifáticos primarios de alto peso molecular purificada de la cera de abejas, ha mostrado efectos antiinflamatorios, sin gastrotoxicidad secundaria, enmodelos experimentales. El tratamiento oral con D-002 reduce las concentraciones de leucotrieno B4 (LTB4 en exudados pleurales de ratas con pleuresía por carragenina, sugiriendo que podría inhibir la actividad enzimática de la 5-lipooxigenasa (5-LOX, si bien los mecanismos de la acción antiinflamatoria del D-002 no habían sido aún explorados. Objetivo: evaluar el efecto in vitro del D-002 sobre la actividad de la 5-LOX, utilizando la fracción citosólica de homogenatos de hígado de ratas. Métodos: las condiciones de ensayo utilizadas fueron las siguientes: fracción citosólica (50 µg de proteína disuelta en solución reguladora borato 0,2 mol/L (pH 9 y ácido linoleico (7,8-250 mmol/L como sustrato, ensayándose muestras paralelas incubadas con Tween-20/H2O (2 % (vehículo, muestras controles, D-002 (0,9-1 000 µg/mL o Lyprinol (500 µg/mL (sustancia de referencia. La actividad enzimática se evaluó mediante el cambio de absorbancia a 234 nm producido por la formación de dienos conjugados y medido en espectrofotómetro UV-visible. Resultados: la adición in vitro del D-002 produjo una inhibición significativa, dependiente de la dosis (r= 0,980; p< 0,001 (IC50= 95,34 µg/mL e incompetitiva de la actividad de la 5-LOX, cuya inhibición máxima (70 % se alcanzó con 500 µg/mL. Conclusiones: con este estudio se demuestra que el D-002 es capaz de inhibir la actividad enzimática de la 5-LOX, efecto que podría explicar, al menos parcialmente, su acción antiinflamatoria en modelos experimentales in vivo.

Efecto in vitro del D-003 sobre la actividad enzimática de la 5-lipoxigenasa (5-LOX

Directory of Open Access Journals (Sweden)

Yohani Pérez Guerra

Full Text Available Introducción: el D-003, mezcla de ácidos alifáticos primarios superiores purificada de la cera de la caña, inhibe la síntesis de colesterol. Trabajos recientes han demostrado que el D-003 resulta efectivo en modelos experimentales de osteoartritis y que inhibe la actividad de las enzimas COX1 y COX2, preferentemente la COX1, sin producir gastrotoxicidad. Ha sido referido que los inhibidores duales de las enzimas COX y 5-LOX presentan efectos antinflamatorios desprovistos de gastrotoxicidad o que incluso, pueden resultar gastroprotectores. De acuerdo con estos antecedentes, el D-003 podría ser un inhibidor dual de dichas enzimas. Objetivo: investigar el efecto in vitro del D-003 sobre la actividad enzimática de la 5-LOX, utilizando la fracción citosólica de leucocitos polimorfonucleares de ratas. Métodos: se utilizaron las condiciones de ensayo siguientes: fracción citosólica (50 µg de proteína disuelta en solución reguladora borato 0,2 mol/L (pH 9 y ácido linoleico (7,8-250 mmol/L como sustrato, ensayándose muestras paralelas incubadas con Tween-20/H2O (2 % (vehículo, D-003 (0,6-6 000 µg/mL o extracto de Perna canaliculus (50 µg/mL (sustancia de referencia. Se evaluó la actividad enzimática mediante el cambio de absorbancia a 234 nm producido por la formación de dienos conjugados y medido en espectrofotómetro UV-visible. Resultados: la adición de D-003 produjo una inhibición dosis dependiente de la actividad enzimática de la 5-LOX (r= 0,975; p< 0,05 (CI50= 23,06 µg/mL in vitro. La magnitud de esta inhibición fue moderada, ya que la inhibición máxima, alcanzada a partir de 1 250 µg/mL, resultó de solo un 30 %. Conclusiones: el estudio demuestra que el D-003 es capaz de inhibir la actividad enzimática de la 5-LOX in vitro, pero moderadamente.

Nuclear thermal propulsion engine based on particle bed reactor using light water steam as a propellant

Science.gov (United States)

Powell, James R.; Ludewig, Hans; Maise, George

1993-01-01

In this paper the possibility of configuring a water cooled Nuclear Thermal Propulsion (NTP) rocket, based on a Particle Bed Reactor (PBR) is investigated. This rocket will be used to operate on water obtained from near earth objects. The conclusions reached in this paper indicate that it is possible to configure a PBR based NTP rocket to operate on water and meet the mission requirements envisioned for it. No insurmountable technology issues have been identified.

Nuclear thermal propulsion engine based on particle bed reactor using light water steam as a propellant

International Nuclear Information System (INIS)

Powell, J.R.; Ludewig, H.; Maise, G.

1993-01-01

In this paper the possibility of configuring a water cooled Nuclear Thermal Propulsion (NTP) rocket, based on a Particle Bed Reactor (PBR) is investigated. This rocket will be used to operate on water obtained from near earth objects. The conclusions reached in this paper indicate that it is possible to configure a PBR based NTP rocket to operate on water and meet the mission requirements envisioned for it. No insurmountable technology issues have been identified

The influence of speed and grade on wheelchair propulsion hand pattern.

Science.gov (United States)

Slowik, Jonathan S; Requejo, Philip S; Mulroy, Sara J; Neptune, Richard R

2015-11-01

The hand pattern used during manual wheelchair propulsion (i.e., full-cycle hand path) can provide insight into an individual's propulsion technique. However, previous analyses of hand patterns have been limited by their focus on a single propulsion condition and reliance on subjective qualitative characterization methods. The purpose of this study was to develop a set of objective quantitative parameters to characterize hand patterns and determine the influence of propulsion speed and grade of incline on the patterns preferred by manual wheelchair users. Kinematic and kinetic data were collected from 170 experienced manual wheelchair users on an ergometer during three conditions: level propulsion at their self-selected speed, level propulsion at their fastest comfortable speed and graded propulsion (8%) at their level self-selected speed. Hand patterns were quantified using a set of objective parameters, and differences across conditions were identified. Increased propulsion speed resulted in a shift away from under-rim hand patterns. Increased grade of incline resulted in the hand remaining near the handrim throughout the cycle. Manual wheelchair users change their hand pattern based on task-specific constraints and goals. Further work is needed to investigate how differences between hand patterns influence upper extremity demand and potentially lead to the development of overuse injuries and pain. Copyright © 2015 Elsevier Ltd. All rights reserved.

Coil-On-Plug Ignition for Oxygen/Methane Liquid Rocket Engines in Thermal-Vacuum Environments

Science.gov (United States)

Melcher, John C.; Atwell, Matthew J.; Morehead, Robert L.; Hurlbert, Eric A.; Bugarin, Luz; Chaidez, Mariana

2017-01-01

A coil-on-plug ignition system has been developed and tested for Liquid Oxygen (LOX)/liquid methane (LCH4) rocket engines operating in thermal vacuum conditions. The igniters were developed and tested as part of the Integrated Cryogenic Propulsion Test Article (ICPTA), previously tested as part of the Project Morpheus test vehicle. The ICPTA uses an integrated, pressure-fed, cryogenic LOX/LCH4 propulsion system including a reaction control system (RCS) and a main engine. The ICPTA was tested at NASA Glenn Research Center's Plum Brook Station in the Spacecraft Propulsion Research Facility (B-2) under vacuum and thermal vacuum conditions. A coil-on-plug ignition system has been developed to successfully demonstrate ignition reliability at these conditions while preventing corona discharge issues. The ICPTA uses spark plug ignition for both the main engine igniter and the RCS. The coil-on-plug configuration eliminates the conventional high-voltage spark plug cable by combining the coil and the spark plug into a single component. Prior to ICPTA testing at Plum Brook, component-level reaction control engine (RCE) and main engine igniter testing was conducted at NASA Johnson Space Center (JSC), which demonstrated successful hot-fire ignition using the coil-on-plug from sea-level ambient conditions down to 10(exp -2) torr. Integrated vehicle hot-fire testing at JSC demonstrated electrical and command/data system performance. Lastly, hot-fire testing at Plum Brook demonstrated successful ignitions at simulated altitude conditions at 30 torr and cold thermal-vacuum conditions at 6 torr. The test campaign successfully proved that coil-on-plug technology will enable integrated LOX/LCH4 propulsion systems in future spacecraft.

A Review of Laser Ablation Propulsion

International Nuclear Information System (INIS)

Phipps, Claude; Bohn, Willy; Lippert, Thomas; Sasoh, Akihiro; Schall, Wolfgang; Sinko, John

2010-01-01

Laser Ablation Propulsion is a broad field with a wide range of applications. We review the 30-year history of laser ablation propulsion from the transition from earlier pure photon propulsion concepts of Oberth and Saenger through Kantrowitz's original laser ablation propulsion idea to the development of air-breathing 'Lightcraft' and advanced spacecraft propulsion engines. The polymers POM and GAP have played an important role in experiments and liquid ablation fuels show great promise. Some applications use a laser system which is distant from the propelled object, for example, on another spacecraft, the Earth or a planet. Others use a laser that is part of the spacecraft propulsion system on the spacecraft. Propulsion is produced when an intense laser beam strikes a condensed matter surface and produces a vapor or plasma jet. The advantages of this idea are that exhaust velocity of the propulsion engine covers a broader range than is available from chemistry, that it can be varied to meet the instantaneous demands of the particular mission, and that practical realizations give lower mass and greater simplicity for a payload delivery system. We review the underlying theory, buttressed by extensive experimental data. The primary problem in laser space propulsion theory has been the absence of a way to predict thrust and specific impulse over the transition from the vapor to the plasma regimes. We briefly discuss a method for combining two new vapor regime treatments with plasma regime theory, giving a smooth transition from one regime to the other. We conclude with a section on future directions.

Analysis of conditional gene deletion using probe based Real-Time PCR

Directory of Open Access Journals (Sweden)

Lyko Frank

2010-12-01

Full Text Available Abstract Following publication of this article 1 the authors noticed that an incorrect probe reference was cited on page 3, 4, 5 and 6 ("UP #69, Roche Applied Science". The correct probe that was used for the 1lox/2lox allele ratio analysis in the paper is as follows Probe for 1lox/2lox allele quantification: 5'-6-FAM-atAaCtTCgtatagCATaCattatac-BHQ-1 -3' (uppercase letters = LNA bases Manufacturer: EUROGENTEC, Seraing, Belgium All other information and reaction conditions in the paper are correct as stated.

Cooling of Electric Motors Used for Propulsion on SCEPTOR

Science.gov (United States)

Christie, Robert J.; Dubois, Arthur; Derlaga, Joseph M.

2017-01-01

NASA is developing a suite of hybrid-electric propulsion technologies for aircraft. These technologies have the benefit of lower emissions, diminished noise, increased efficiency, and reduced fuel burn. These will provide lower operating costs for aircraft operators. Replacing internal combustion engines with distributed electric propulsion is a keystone of this technology suite, but presents many new problems to aircraft system designers. One of the problems is how to cool these electric motors without adding significant aerodynamic drag, cooling system weight or fan power. This paper discusses the options evaluated for cooling the motors on SCEPTOR (Scalable Convergent Electric Propulsion Technology and Operations Research): a project that will demonstrate Distributed Electric Propulsion technology in flight. Options for external and internal cooling, inlet and exhaust locations, ducting and adjustable cowling, and axial and centrifugal fans were evaluated. The final design was based on a trade between effectiveness, simplicity, robustness, mass and performance over a range of ground and flight operation environments.

Numerical simulation of the flow around a steerable propulsion unit

International Nuclear Information System (INIS)

Pacuraru, F; Lungu, A; Ungureanu, C; Marcu, O

2010-01-01

Azimuth propulsion units have become during the last decade a more and more popular solution for all kinds of vessels. Azimuth thruster system, combining the propulsion and steering units of conventional ships replaces traditional propellers and lengthy drive shafts and rudders ensuring an excellent vessel steering. In many cases the interaction between the propeller and other components of the propulsion system strongly affects the inflow to the propeller and therefore its performance. The correct estimation of this influence is important for propulsion systems which consist of more than one element, such as pods (shaft, gondola and propeller), ducted propellers (duct, struts and propeller) or bow thrusters (ship form, tunnel, gondola and propeller). The paper proposes a numerical investigation based on RANS computation for solving the viscous flow around an azimuth thruster system to provide a detailed insight into the critical flow regions for determining the optimum inclination angle for struts, for studying the hydrodynamic interactions between various components of the system, for predicting the hydrodynamic performance of the propulsion system and to investigate regions with possible flow separations.

Solar System Exploration Augmented by In-Situ Resource Utilization: Mercury and Saturn Propulsion Investigations

Science.gov (United States)

Palaszewski, Bryan

2016-01-01

Human and robotic missions to Mercury and Saturn are presented and analyzed with a range of propulsion options. Historical studies of space exploration, in-situ resource utilization (ISRU), and industrialization all point to the vastness of natural resources in the solar system. Advanced propulsion benefitted from these resources in many ways. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear pulse propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Updated analyses based on these historical visions will be presented. Nuclear thermal propulsion and ISRU enhanced chemical propulsion landers are assessed for Mercury missions. At Saturn, nuclear pulse propulsion with alternate propellant feed systems and Titan exploration with chemical propulsion options are discussed. In-situ resource utilization was found to be critical in making Mercury missions more amenable for human visits. At Saturn, refueling using local atmospheric mining was found to be difficult to impractical, while refueling the Saturn missions from Uranus was more practical and less complex.

Propulsive efficiency and non- expert swimmers performance

Directory of Open Access Journals (Sweden)

Tiago Barbosa

2009-12-01

Full Text Available Propulsive efficiency is one of the most interesting issues for competitive swimming researchers, has it presents significant relationships with the swimmer’s biophysical behavior and his/her performance. Although propulsive efficiency is a variable that has been quite studied in elite swimmers, there is no research on this issue in young and non-expert swimmers. Thus, the aim of this study was to: (i estimate the propulsive efficiency on non-expert swimmers; (ii identify biomechanical and anthropometrical parameters that are associated with propulsive efficiency; (iii identify the association between the propulsive efficiency and swim performance. Twenty-eight non-expert swimmers participated on this study. It was assessed the propulsive efficiency, biomechanical and anthropometrical parameters, as well as, the swim performance. The propulsive efficiency of non-expert swimmers is lower than data reported in the literature to higher competitive levels swimmers and there are no significant differences between boys and girls. It was also noted that several biomechanical and anthropometrical parameters, as well as, the swim performance are associated with the propulsive efficiency.

RSMASS-D nuclear thermal propulsion and bimodal system mass models

Science.gov (United States)

King, Donald B.; Marshall, Albert C.

1997-01-01

Two relatively simple models have been developed to estimate reactor, radiation shield, and balance of system masses for a particle bed reactor (PBR) nuclear thermal propulsion concept and a cermet-core power and propulsion (bimodal) concept. The approach was based on the methodology developed for the RSMASS-D models. The RSMASS-D approach for the reactor and shield sub-systems uses a combination of simple equations derived from reactor physics and other fundamental considerations along with tabulations of data from more detailed neutron and gamma transport theory computations. Relatively simple models are used to estimate the masses of other subsystem components of the nuclear propulsion and bimodal systems. Other subsystem components include instrumentation and control (I&C), boom, safety systems, radiator, thermoelectrics, heat pipes, and nozzle. The user of these models can vary basic design parameters within an allowed range to achieve a parameter choice which yields a minimum mass for the operational conditions of interest. Estimated system masses are presented for a range of reactor power levels for propulsion for the PBR propulsion concept and for both electrical power and propulsion for the cermet-core bimodal concept. The estimated reactor system masses agree with mass predictions from detailed calculations with xx percent for both models.

RF emission-based health monitoring for hybrid and/or all electric aircraft distributed propulsion systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Future aircraft propulsion is destined to be electric. All electric aircraft propulsion systems promise significant improvements in energy efficiency,...

Sensorless control of ship propulsion interior permanent magnet synchronous motor based on a new sliding mode observer.

Science.gov (United States)

Ren, Jun-Jie; Liu, Yan-Cheng; Wang, Ning; Liu, Si-Yuan

2015-01-01

This paper proposes a sensorless speed control strategy for ship propulsion interior permanent magnet synchronous motor (IPMSM) based on a new sliding-mode observer (SMO). In the SMO the low-pass filter and the method of arc-tangent calculation of extended electromotive force (EMF) or phase-locked loop (PLL) technique are not used. The calculation of the rotor speed is deduced from the Lyapunov function stability analysis. In order to reduce system chattering, sigmoid functions with switching gains being adaptively updated by fuzzy logic systems are innovatively incorporated into the SMO. Finally, simulation results for a 4.088 MW ship propulsion IPMSM and experimental results from a 7.5 kW IPMSM drive are provided to verify the effectiveness of the proposed SMO method. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

Research Opportunities in Space Propulsion

Science.gov (United States)

Rodgers, Stephen L.

2007-01-01

Rocket propulsion determines the primary characteristics of any space vehicle; how fast and far it can go, its lifetime, and its capabilities. It is the primary factor in safety and reliability and the biggest cost driver. The extremes of heat and pressure produced by propulsion systems push the limits of materials used for manufacturing. Space travel is very unforgiving with little room for errors, and so many things can go wrong with these very complex systems. So we have to plan for failure and that makes it costly. But what is more exciting than the roar of a rocket blasting into space? By its nature the propulsion world is conservative. The stakes are so high at every launch, in terms of payload value or in human life, that to introduce new components to a working, qualified system is extremely difficult and costly. Every launch counts and no risks are tolerated, which leads to the space world's version of Catch-22:"You can't fly till you flown." The last big 'game changer' in propulsion was the use of liquid hydrogen as a fuel. No new breakthrough, low cost access to space system will be developed without new efficient propulsion systems. Because there is no large commercial market driving investment in propulsion, what propulsion research is done is sponsored by government funding agencies. A further difficulty in propulsion technology development is that there are so few new systems flying. There is little opportunity to evolve propulsion technologies and to update existing systems with results coming out of research as there is in, for example, the auto industry. The biggest hurdle to space exploration is getting off the ground. The launch phase will consume most of the energy required for any foreseeable space exploration mission. The fundamental physical energy requirements of escaping earth's gravity make it difficult. It takes 60,000 kJ to put a kilogram into an escape orbit. The vast majority (-97%) of the energy produced by a launch vehicle is used

Propulsion System and Orbit Maneuver Integration in CubeSats: Trajectory Control Strategies Using Micro Ion Propulsion

Science.gov (United States)

Hudson, Jennifer; Martinez, Andres; Petro, Andrew

2015-01-01

The Propulsion System and Orbit Maneuver Integration in CubeSats project aims to solve the challenges of integrating a micro electric propulsion system on a CubeSat in order to perform orbital maneuvers and control attitude. This represents a fundamentally new capability for CubeSats, which typically do not contain propulsion systems and cannot maneuver far beyond their initial orbits.

An Overview of the NASA Aviation Safety Program Propulsion Health Monitoring Element

Science.gov (United States)

Simon, Donald L.

2000-01-01

The NASA Aviation Safety Program (AvSP) has been initiated with aggressive goals to reduce the civil aviation accident rate, To meet these goals, several technology investment areas have been identified including a sub-element in propulsion health monitoring (PHM). Specific AvSP PHM objectives are to develop and validate propulsion system health monitoring technologies designed to prevent engine malfunctions from occurring in flight, and to mitigate detrimental effects in the event an in-flight malfunction does occur. A review of available propulsion system safety information was conducted to help prioritize PHM areas to focus on under the AvSP. It is noted that when a propulsion malfunction is involved in an aviation accident or incident, it is often a contributing factor rather than the sole cause for the event. Challenging aspects of the development and implementation of PHM technology such as cost, weight, robustness, and reliability are discussed. Specific technology plans are overviewed including vibration diagnostics, model-based controls and diagnostics, advanced instrumentation, and general aviation propulsion system health monitoring technology. Propulsion system health monitoring, in addition to engine design, inspection, maintenance, and pilot training and awareness, is intrinsic to enhancing aviation propulsion system safety.

Mirror fusion propulsion system - A performance comparison with alternate propulsion systems for the manned Mars mission

International Nuclear Information System (INIS)

Deveny, M.; Carpenter, S.; O'connell, T.; Schulze, N.

1993-06-01

The performance characteristics of several propulsion technologies applied to piloted Mars missions are compared. The characteristics that are compared are Initial Mass in Low Earth Orbit (IMLEO), mission flexibility, and flight times. The propulsion systems being compared are both demonstrated and envisioned: Chemical (or Cryogenic), Nuclear Thermal Rocket (NTR) solid core, NTR gas core, Nuclear Electric Propulsion (NEP), and a mirror fusion space propulsion system. The proposed magnetic mirror fusion reactor, known as the Mirror Fusion Propulsion System (MFPS), is described. The description is an overview of a design study that was conducted to convert a mirror reactor experiment at Lawrence Livermore National Lab (LLNL) into a viable space propulsion system. Design principles geared towards minimizing mass and maximizing power available for thrust are identified and applied to the LLNL reactor design, resulting in the MFPS. The MFPS' design evolution, reactor and fuel choices, and system configuration are described. Results of the performance comparison shows that the MFPS minimizes flight time to 60 to 90 days for flights to Mars while allowing continuous return-home capability while at Mars. Total MFPS IMLEO including propellant and payloads is kept to about 1,000 metric tons. 50 refs

Concept Study of Radio Frequency (RF Plasma Thruster for Space Propulsion

Directory of Open Access Journals (Sweden)

Anna-Maria Theodora ANDREESCU

2016-12-01

Full Text Available Electric thrusters are capable of accelerating ions to speeds that are impossible to reach using chemical reaction. Recent advances in plasma-based concepts have led to the identification of electromagnetic (RF generation and acceleration systems as able to provide not only continuous thrust, but also highly controllable and wide-range exhaust velocities. For Future Space Propulsion there is a pressing need for low pressure, high mass flow rate and controlled ion energies. This paper explores the potential of using RF heated plasmas for space propulsion in order to mitigate the electric propulsion problems caused by erosion and gain flexibility in plasma manipulation. The main key components of RF thruster architecture are: a feeding system able to provide the required neutral gas flow, plasma source chamber, antenna/electrodes wrapped around the discharge tube and optimized electromagnetic field coils for plasma confinement. A preliminary analysis of system performance (thrust, specific impulse, efficiency is performed along with future plans of Space Propulsion based on this new concept of plasma mechanism.

Carbon Nanotube Based Electric Propulsion Thruster with Low Power Consumption, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Field emission electric propulsion (FEEP) thrusters have gained considerable attention for spacecrafts disturbance compensation because of excellent characteristics....

CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing.

Science.gov (United States)

Ma, Yuanwu; Yu, Lei; Pan, Shuo; Gao, Shan; Chen, Wei; Zhang, Xu; Dong, Wei; Li, Jing; Zhou, Rui; Huang, Lan; Han, Yunlin; Bai, Lin; Zhang, Li; Zhang, Lianfeng

2017-10-01

The rat is an important laboratory animal for physiological, toxicological and pharmacological studies. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) is a simple and efficient tool to generate precise genetic modifications in rats, which will promote the accumulation of genetic resources and enable more precise studies of gene function. To monitor Cre-loxP-mediated excision in vivo, we generated a Cre reporter rat strain (Rosa26-imCherry) by knockin of a Cre reporter cassette at the Rosa26 locus using CRISPR/Cas9. Rosa26-imCherry rats exhibited inducible expression of the mCherry cassette (imCherry) using the Cre-loxP system, whereas normal rats exhibited ubiquitous expression of eGFP but not mCherry in the whole body. Injection of adeno-associated virus serotype 9-Cre into the hippocampus and skeletal muscle resulted in mCherry expression in virus-infected cells. Cre-loxP-mediated mCherry expression was then evaluated by crossing Rosa26-imCherry rats with transgenic rats ubiquitously expressing CAG-Cre, heart-specific α-MHC-Cre transgenic rats and liver-specific Alb-Cre knockin rats. Finally, using the established system the expression pattern of Cre driven by two endogenous gene promoters (Wfs1-Cre knockin rat, FabP2-Cre knockin rat) was traced. In summary, we demonstrated excision of the loxP-flanked allele in Rosa26-imCherry rats via activation of mCherry expression in the presence of Cre recombinase. This newly established Rosa26-imCherry rat strain represents a useful tool to facilitate Cre-expression pattern determination and tracing experiments. © 2017 Federation of European Biochemical Societies.

Alternative Hydrocarbon Propulsion for Nano / Micro Launch Vehicle, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The technical innovation proposed here is the application of an alternative hydrocarbon fuel – densified propylene, in combination with liquid oxygen (LOX) – that...

Distributed propulsion.

OpenAIRE

Lindström, Robin; Rosvall, Tobias

2013-01-01

En prestandaanalys utfördes på en SAAB 2000 som referensobjekt. Olika metoder för att driva flygplan på ett miljövänligare sätt utvärderades tillsammans med distributed propulsion. Efter undersökningar valdes elmotorer tillsammans med Zink-luft batterier för att driva SAAB 2000 med distributed propulsion. En prestandaanalys utfördes på detta plan på samma sätt som för den ursprungliga SAAB 2000. Resultaten jämfördes och slutsatsen blev att räckvidden var för kort för att konfigurationen skull...

Web-Based Distributed Simulation of Aeronautical Propulsion System

Science.gov (United States)

Zheng, Desheng; Follen, Gregory J.; Pavlik, William R.; Kim, Chan M.; Liu, Xianyou; Blaser, Tammy M.; Lopez, Isaac

2001-01-01

An application was developed to allow users to run and view the Numerical Propulsion System Simulation (NPSS) engine simulations from web browsers. Simulations were performed on multiple INFORMATION POWER GRID (IPG) test beds. The Common Object Request Broker Architecture (CORBA) was used for brokering data exchange among machines and IPG/Globus for job scheduling and remote process invocation. Web server scripting was performed by JavaServer Pages (JSP). This application has proven to be an effective and efficient way to couple heterogeneous distributed components.

Vehicle with inclinable caterpillar propulsion units

International Nuclear Information System (INIS)

Clar, G.

1991-01-01

This vehicle usable in hostile environment such nuclear industry has four propulsion units with a caterpillar track and two integrated motors: one for advancing the caterpillar track and the other for inclining the propulsion unit when overcoming obstacles. Each propulsion unit is easily replaceable because there are no mechanical parts in the body of the vehicle [fr

Vehicle and Mission Design Options for the Human Exploration of Mars/Phobos Using "Bimodal" NTR and LANTR Propulsion

Science.gov (United States)

Borowski, Stanley K.; Dudzinski, Leonard A.; McGuire, Melissa L.

2002-12-01

available in Mars orbit grows to 150 kWe compared to 30 kWe for the DRM. Propulsive capture also eliminates the complex, higher risk aerobraking and capture maneuver which is replaced by a simpler reentry using a standardized, lower mass "aerodescent" shell. The attractiveness of the "all BNTR" option is further increased by the substitution of the lightweight, inflatable "TransHab" module in place of the heavier, hard-shell hab module. Use of TransHab introduces the potential for propulsive recovery and reuse of the BNTR / Earth return vehicle (ERV). It also allows the crew to travel to and from Mars on the same BNTR transfer vehicle thereby cutting the duration of the ERV mission in half--from approximately 4.7 to 2.5 years. Finally, for difficult Mars options, such as Phobos rendezvous and sample return missions, volume (not mass) constraints limit the performance of the "all LH2" BNTR stage. The use of "LOX-augmented" NTR (LANTR) engines, operating at a modest oxygen-to-hydrogen mixture ratio (MR) of 0.5, helps to increase "bulk" propellant density and total thrust during the TMI burn. On all subsequent burns, the bimodal LANTR engines operate on LH2 only (MR=0) to maximize vehicle performance while staying within the mass limits of two Magnum launches.

Propulsion Utilizing Laser-Driven Ponderomotive Fields for Deep-Space Missions

International Nuclear Information System (INIS)

Williams, George J.; Gilland, James H.

2009-01-01

The generation of large amplitude electric fields in plasmas by high-power lasers has been studied for several years in the context of high-energy particle acceleration. Fields on the order of GeV/m are generated in the plasma wake of the laser by non-linear ponderomotive forces. The laser fields generate longitudinal and translational electron plasma waves with phase velocities close to the speed of light. These fields and velocities offer the potential to revolutionize spacecraft propulsion, leading to extended deep space robotic probes. Based on these initial calculations, plasma acceleration by means of laser-induced ponderomotive forces appears to offer significant potential for spacecraft propulsion. Relatively high-efficiencies appear possible with proper beam conditioning, resulting in an order of magnitude more thrust than alternative concepts for high I SP (>10 5 s) and elimination of the primary life-limiting erosion phenomena associated with conventional electric propulsion systems. Ponderomotive propulsion readily lends itself to beamed power which might overcome some of the constraints of power-limited propulsion concepts. A preliminary assessment of the impact of these propulsion systems for several promising configurations on mission architectures has been conducted. Emphasizing interstellar and interstellar-precursor applications, performance and technical requirements are identified for a number of missions. The use of in-situ plasma and gas for propellant is evaluated as well.

Distributed propulsion and future aerospace technologies

OpenAIRE

Ameyugo, Gregorio

2007-01-01

This thesis describes an Engineering Doctorate project in Distributed Propulsion carried out from 2004 to 2007 at Cranfield University. Distributed propulsion is a propulsion system arrangement that consists in spreading the engine thrust along the aircraft span. This can be accomplished by distributing a series of driven fans or the engines themselves. The aim of this project is to determine the feasibility of ...

Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.

Science.gov (United States)

Tognatta, Reshmi; Sun, Wenjing; Goebbels, Sandra; Nave, Klaus-Armin; Nishiyama, Akiko; Schoch, Susanne; Dimou, Leda; Dietrich, Dirk

2017-02-01

NG2 expressing oligodendroglial precursor cells are ubiquitous in the central nervous system and the only cell type cycling throughout life. Previous fate mapping studies have remained inconsistent regarding the question whether NG2 cells are capable of generating certain types of neurons. Here, we use CNP-Cre mice to map the fate of a sub-population of NG2 cells assumed to be close to differentiation. When crossing these mice with the ROSA26/YFP Cre-reporter line we discovered large numbers of reporter-expressing pyramidal neurons in the piriform and dorsal cortex. In contrast, when using Z/EG reporter mice to track the fate of Cnp-expressing NG2 cells only oligodendroglial cells were found reporter positive. Using BrdU-based birth dating protocols and inducible NG2CreER:ROSA26/YFP mice we show that YFP positive neurons are generated from radial glial cells and that these radial glial cells display temporary and low level activity of certain oligodendroglial genes sufficient to recombine the Cre-inducible reporter gene in ROSA26/YFP but not in Z/EG mice. Taken together, we did not obtain evidence for generation of neurons from NG2 cells. Our results suggest that with an appropriate reporter system Cnp activity can be used to define a proliferative subpopulation of NG2 cells committed to generate oligodendrocytes. However, the strikingly different results obtained from ROSA26/YFP versus Z/EG mice demonstrate that the choice of Cre-reporter line can be of crucial importance for fate mapping studies and other applications of the Cre-lox technology. GLIA 2017;65:342-359. © 2016 Wiley Periodicals, Inc.

The multidisciplinary design optimization of a distributed propulsion blended-wing-body aircraft

Science.gov (United States)

Ko, Yan-Yee Andy

The purpose of this study is to examine the multidisciplinary design optimization (MDO) of a distributed propulsion blended-wing-body (BWB) aircraft. The BWB is a hybrid shape resembling a flying wing, placing the payload in the inboard sections of the wing. The distributed propulsion concept involves replacing a small number of large engines with many smaller engines. The distributed propulsion concept considered here ducts part of the engine exhaust to exit out along the trailing edge of the wing. The distributed propulsion concept affects almost every aspect of the BWB design. Methods to model these effects and integrate them into an MDO framework were developed. The most important effect modeled is the impact on the propulsive efficiency. There has been conjecture that there will be an increase in propulsive efficiency when there is blowing out of the trailing edge of a wing. A mathematical formulation was derived to explain this. The formulation showed that the jet 'fills in' the wake behind the body, improving the overall aerodynamic/propulsion system, resulting in an increased propulsive efficiency. The distributed propulsion concept also replaces the conventional elevons with a vectored thrust system for longitudinal control. An extension of Spence's Jet Flap theory was developed to estimate the effects of this vectored thrust system on the aircraft longitudinal control. It was found to provide a reasonable estimate of the control capability of the aircraft. An MDO framework was developed, integrating all the distributed propulsion effects modeled. Using a gradient based optimization algorithm, the distributed propulsion BWB aircraft was optimized and compared with a similarly optimized conventional BWB design. Both designs are for an 800 passenger, 0.85 cruise Mach number and 7000 nmi mission. The MDO results found that the distributed propulsion BWB aircraft has a 4% takeoff gross weight and a 2% fuel weight. Both designs have similar planform shapes

Carbon Nanotube Based Electric Propulsion Thruster with Low Power Consumption, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This SBIR project is to develop field emission electric propulsion (FEEP) thruster using carbon nanotubes (CNT) integrated anode. FEEP thrusters have gained...

Enabling Electric Propulsion for Flight

Science.gov (United States)

Ginn, Starr Renee

2015-01-01

Team Seedling project AFRC and LaRC 31ft distributed electric propulsion wing on truck bed up 75 miles per hour for coefficient of lift validation. Convergent Aeronautic Solutions project, sub-project Convergent Electric Propulsion Technologies AFRC, LaRC and GRC, re-winging a 4 passenger Tecnam aircraft with a 31ft distributed electric propulsion wing. Advanced Air Transport Technologies (Fixed Wing), Hybrid Electric Research Theme, developing a series hybrid ironbird and flight sim to study integration and performance challenges in preparation for a 1-2 MW flight project.

Economic effects of propulsion system technology on existing and future transport aircraft

Science.gov (United States)

Sallee, G. P.

1974-01-01

The results of an airline study of the economic effects of propulsion system technology on current and future transport aircraft are presented. This report represents the results of a detailed study of propulsion system operating economics. The study has four major parts: (1) a detailed analysis of current propulsion system maintenance with respect to the material and labor costs encountered versus years in service and the design characteristics of the major elements of the propulsion system of the B707, b727, and B747. (2) an analysis of the economic impact of a future representative 1979 propulsion system is presented with emphasis on depreciation of investment, fuel costs and maintenance costs developed on the basis of the analysis of the historical trends observed. (3) recommendations concerning improved methods of forecasting the maintenance cost of future propulsion systems are presented. A detailed method based on the summation of the projected labor and material repair costs for each major engine module and its installation along with a shorter form suitable for quick, less detailed analysis are presented, and (4) recommendations concerning areas where additional technology is needed to improve the economics of future commercial propulsion systems are presented along with the suggested economic benefits available from such advanced technology efforts.

Aeroelastic Wing Shaping Using Distributed Propulsion

Science.gov (United States)

Nguyen, Nhan T. (Inventor); Reynolds, Kevin Wayne (Inventor); Ting, Eric B. (Inventor)

2017-01-01

An aircraft has wings configured to twist during flight. Inboard and outboard propulsion devices, such as turbofans or other propulsors, are connected to each wing, and are spaced along the wing span. A flight controller independently controls thrust of the inboard and outboard propulsion devices to significantly change flight dynamics, including changing thrust of outboard propulsion devices to twist the wing, and to differentially apply thrust on each wing to change yaw and other aspects of the aircraft during various stages of a flight mission. One or more generators can be positioned upon the wing to provide power for propulsion devices on the same wing, and on an opposite wing.

A motor learning approach to training wheelchair propulsion biomechanics for new manual wheelchair users: A pilot study.

Science.gov (United States)

Morgan, Kerri A; Tucker, Susan M; Klaesner, Joseph W; Engsberg, Jack R

2017-05-01

Developing an evidence-based approach to teaching wheelchair skills and proper propulsion for everyday wheelchair users with a spinal cord injury (SCI) is important to their rehabilitation. The purpose of this project was to pilot test manual wheelchair training based on motor learning and repetition-based approaches for new manual wheelchair users with an SCI. A repeated measures within-subject design was used with participants acting as their own controls. Six persons with an SCI requiring the use of a manual wheelchair participated in wheelchair training. The training included nine 90-minute sessions. The primary focus was on wheelchair propulsion biomechanics with a secondary focus on wheelchair skills. During Pretest 1, Pretest 2, and Posttest, wheelchair propulsion biomechanics were measured using the Wheelchair Propulsion Test and a Video Motion Capture system. During Pretest 2 and Posttest, propulsion forces using the WheelMill System and wheelchair skills using the Wheelchair Skills Test were measured. Significant changes in area of the push loop, hand-to-axle relationship, and slope of push forces were found. Changes in propulsion patterns were identified post-training. No significant differences were found in peak and average push forces and wheelchair skills pre- and post-training. This project identified trends in change related to a repetition-based motor learning approach for propelling a manual wheelchair. The changes found were related to the propulsion patterns used by participants. Despite some challenges associated with implementing interventions for new manual wheelchair users, such as recruitment, the results of this study show that repetition-based training can improve biomechanics and propulsion patterns for new manual wheelchair users.

Visions of the Future: Hybrid Electric Aircraft Propulsion

Science.gov (United States)

Bowman, Cheryl L.

2016-01-01

The National Aeronautics and Space Administration (NASA) is investing continually in improving civil aviation. Hybridization of aircraft propulsion is one aspect of a technology suite which will transform future aircraft. In this context, hybrid propulsion is considered a combination of traditional gas turbine propulsion and electric drive enabled propulsion. This technology suite includes elements of propulsion and airframe integration, parallel hybrid shaft power, turbo-electric generation, electric drive systems, component development, materials development and system integration at multiple levels.

MW-Class Electric Propulsion System Designs

Science.gov (United States)

LaPointe, Michael R.; Oleson, Steven; Pencil, Eric; Mercer, Carolyn; Distefano, Salvador

2011-01-01

Electric propulsion systems are well developed and have been in commercial use for several years. Ion and Hall thrusters have propelled robotic spacecraft to encounters with asteroids, the Moon, and minor planetary bodies within the solar system, while higher power systems are being considered to support even more demanding future space science and exploration missions. Such missions may include orbit raising and station-keeping for large platforms, robotic and human missions to near earth asteroids, cargo transport for sustained lunar or Mars exploration, and at very high-power, fast piloted missions to Mars and the outer planets. The Advanced In-Space Propulsion Project, High Efficiency Space Power Systems Project, and High Power Electric Propulsion Demonstration Project were established within the NASA Exploration Technology Development and Demonstration Program to develop and advance the fundamental technologies required for these long-range, future exploration missions. Under the auspices of the High Efficiency Space Power Systems Project, and supported by the Advanced In-Space Propulsion and High Power Electric Propulsion Projects, the COMPASS design team at the NASA Glenn Research Center performed multiple parametric design analyses to determine solar and nuclear electric power technology requirements for representative 300-kW class and pulsed and steady-state MW-class electric propulsion systems. This paper describes the results of the MW-class electric power and propulsion design analysis. Starting with the representative MW-class vehicle configurations, and using design reference missions bounded by launch dates, several power system technology improvements were introduced into the parametric COMPASS simulations to determine the potential system level benefits such technologies might provide. Those technologies providing quantitative system level benefits were then assessed for technical feasibility, cost, and time to develop. Key assumptions and primary

Applying design principles to fusion reactor configurations for propulsion in space

International Nuclear Information System (INIS)

Carpenter, S.A.; Deveny, M.E.; Schulze, N.R.

1993-01-01

The application of fusion power to space propulsion requires rethinking the engineering-design solution to controlled-fusion energy. Whereas the unit cost of electricity (COE) drives the engineering-design solution for utility-based fusion reactor configurations; initial mass to low earth orbit (IMLEO), specific jet power (kW(thrust)/kg(engine)), and reusability drive the engineering-design solution for successful application of fusion power to space propulsion. Three design principles (DP's) were applied to adapt and optimize three candidate-terrestrial-fusion-reactor configurations for propulsion in space. The three design principles are: provide maximum direct access to space for waste radiation, operate components as passive radiators to minimize cooling-system mass, and optimize the plasma fuel, fuel mix, and temperature for best specific jet power. The three candidate terrestrial fusion reactor configurations are: the thermal barrier tandem mirror (TBTM), field reversed mirror (FRM), and levitated dipole field (LDF). The resulting three candidate space fusion propulsion systems have their IMLEO minimized and their specific jet power and reusability maximized. A preliminary rating of these configurations was performed, and it was concluded that the leading engineering-design solution to space fusion propulsion is a modified TBTM that we call the Mirror Fusion Propulsion System (MFPS)

The Space Nuclear Thermal Propulsion Program: Propulsion for the twenty first century

International Nuclear Information System (INIS)

Bleeker, G.; Moody, J.; Kesaree, M.

1993-01-01

As mission requirements approach the limits of the chemical propulsion systems, new engines must be investigated that can meet the advanced mission requirements of higher payload fractions, higher velocities, and consequently higher specific Impulses (Isp). The propulsion system that can meet these high demands is a nuclear thermal rocket engine. This engine generates the thrust by expanding/existing the hydrogen, heated from the energy derived from the fission process in a reactor, through a nozzle. The Department of Defense (DoD), however, initiated a new nuclear rocket development program in 1987 for ballistic missile defense application. The Space Nuclear Thermal Propulsion (SNTP) Program that seeks to improve on the technology of ROVER/NERVA grew out of this beginning and has been managed by the Air Force, with the involvement of DoE and NASA. The goal of the SNTP Program is to develop an engine to meet potential Air Force requirements for upper stage engine, bimodal propulsion/power applications, and orbital transfer vehicles, as well as the NASA requirements for possible missions to the Moon and Mars. During the entire life of the program, the DoD has considered safety to be of paramount importance, and is following all national environmental policies

Experimental approach of plasma supersonic expansion physics and of Hall effect propulsion systems

International Nuclear Information System (INIS)

Mazouffre, Stephane

2009-01-01

This report for accreditation to supervise research (HDR) proposes a synthesis of scientific and research works performed by the author during about ten years. Thus, a first part addresses studies on plasma rarefied supersonic flows: expansion through a sonic hole and through a Laval nozzle. The next part addresses the study of plasma propulsion for spacecraft, and more particularly electric propulsion based on the Hall effect: phenomena of ionic and atomic transport, characteristics of the electric field, energy deposition on walls, basic scale laws, related works, hybrid Hall-RF propulsion systems. The third part presents perspectives and projects related to propulsion by Hall effect (research topics, planned researches, a European project on high power, hybrid Hall-RF propulsion) and to ions-ions plasma (the PEGASES concept, the NExET test installation, RF source of negative ions and magnetic trap)

Operations of a Radioisotope-based Propulsion System Enabling CubeSat Exploration of the Outer Planets

Energy Technology Data Exchange (ETDEWEB)

Dr. Steven Howe; Nathan Jerred; Troy Howe; Adarsh Rajguru

2014-05-01

Exploration to the outer planets is an ongoing endeavor but in the current economical environment, cost reduction is the forefront of all concern. The success of small satellites such as CubeSats launched to Near-Earth Orbit has lead to examine their potential use to achieve cheaper science for deep space applications. However, to achieve lower cost missions; hardware, launch and operations costs must be minimized. Additionally, as we push towards smaller exploration beds with relative limited power sources, allowing for adequate communication back to Earth is imperative. Researchers at the Center for Space Nuclear Research are developing the potential of utilizing an advanced, radioisotope-based system. This system will be capable of providing both the propulsion power needed to reach the destination and the additional requirements needed to maintain communication while at location. Presented here are a basic trajectory analysis, communication link budget and concept of operations of a dual-mode (thermal and electric) radioisotope-based propulsion system, for a proposed mission to Enceladus (Saturnian icy moon) using a 6U CubeSat payload. The radioisotope system being proposed will be the integration of three sub-systems working together to achieve the overall mission. At the core of the system, stored thermal energy from radioisotope decay is transferred to a passing propellant to achieve high thrust – useful for quick orbital maneuvering. An auxiliary closed-loop Brayton cycle can be operated in parallel to the thrusting mode to provide short bursts of high power for high data-rate communications back to Earth. Additionally, a thermal photovoltaic (TPV) energy conversion system will use radiation heat losses from the core. This in turn can provide the electrical energy needed to utilize the efficiency of ion propulsion to achieve quick interplanetary transit times. The intelligent operation to handle all functions of this system under optimized conditions adds

Powered Flight The Engineering of Aerospace Propulsion

CERN Document Server

Greatrix, David R

2012-01-01

Whilst most contemporary books in the aerospace propulsion field are dedicated primarily to gas turbine engines, there is often little or no coverage of other propulsion systems and devices such as propeller and helicopter rotors or detailed attention to rocket engines. By taking a wider viewpoint, Powered Flight - The Engineering of Aerospace Propulsion aims to provide a broader context, allowing observations and comparisons to be made across systems that are overlooked by focusing on a single aspect alone. The physics and history of aerospace propulsion are built on step-by-step, coupled with the development of an appreciation for the mathematics involved in the science and engineering of propulsion. Combining the author’s experience as a researcher, an industry professional and a lecturer in graduate and undergraduate aerospace engineering, Powered Flight - The Engineering of Aerospace Propulsion covers its subject matter both theoretically and with an awareness of the practicalities of the industry. To ...

Operationally Efficient Propulsion System Study (OEPSS): OEPSS Video Script

Science.gov (United States)

Wong, George S.; Waldrop, Glen S.; Trent, Donnie (Editor)

1992-01-01

The OEPSS video film, along with the OEPSS Databooks, provides a data base of current launch experience that will be useful for design of future expendable and reusable launch systems. The focus is on the launch processing of propulsion systems. A brief 15-minute overview of the OEPSS study results is found at the beginning of the film. The remainder of the film discusses in more detail: current ground operations at the Kennedy Space Center; typical operations issues and problems; critical operations technologies; and efficiency of booster and space propulsion systems. The impact of system architecture on the launch site and its facility infrastucture is emphasized. Finally, a particularly valuable analytical tool, developed during the OEPSS study, that will provide for the "first time" a quantitative measure of operations efficiency for a propulsion system is described.

In-Space Propulsion (346620) Technology Project

Data.gov (United States)

National Aeronautics and Space Administration — Technologies include, but are not limited to, electric and advanced chemical propulsion, propellantless propulsion such as aerocapture and solar sails, sample return...

Powersail High Power Propulsion System Design Study

Science.gov (United States)

Gulczinski, Frank S., III

2000-11-01

A desire by the United States Air Force to exploit the space environment has led to a need for increased on-orbit electrical power availability. To enable this, the Air Force Research Laboratory Space Vehicles Directorate (AFRL/ VS) is developing Powersail: a two-phased program to demonstrate high power (100 kW to 1 MW) capability in space using a deployable, flexible solar array connected to the host spacecraft using a slack umbilical. The first phase will be a proof-of-concept demonstration at 50 kW, followed by the second phase, an operational system at full power. In support of this program, the AFRL propulsion Directorate's Spacecraft Propulsion Branch (AFRL/PRS ) at Edwards AFB has commissioned a design study of the Powersail High Power Propulsion System. The purpose of this study, the results of which are summarized in this paper, is to perform mission and design trades to identify potential full-power applications (both near-Earth and interplanetary) and the corresponding propulsion system requirements and design. The design study shall farther identify a suitable low power demonstration flight that maximizes risk reduction for the fully operational system. This propulsion system is expected to be threefold: (1) primary propulsion for moving the entire vehicle, (2) a propulsion unit that maintains the solar array position relative to the host spacecraft, and (3) control propulsion for maintaining proper orientation for the flexible solar array.

Recent Electric Propulsion Development Activities for NASA Science Missions

Science.gov (United States)

Pencil, Eric J.

2009-01-01

(The primary source of electric propulsion development throughout NASA is managed by the In-Space Propulsion Technology Project at the NASA Glenn Research Center for the Science Mission Directorate. The objective of the Electric Propulsion project area is to develop near-term electric propulsion technology to enhance or enable science missions while minimizing risk and cost to the end user. Major hardware tasks include developing NASA s Evolutionary Xenon Thruster (NEXT), developing a long-life High Voltage Hall Accelerator (HIVHAC), developing an advanced feed system, and developing cross-platform components. The objective of the NEXT task is to advance next generation ion propulsion technology readiness. The baseline NEXT system consists of a high-performance, 7-kW ion thruster; a high-efficiency, 7-kW power processor unit (PPU); a highly flexible advanced xenon propellant management system (PMS); a lightweight engine gimbal; and key elements of a digital control interface unit (DCIU) including software algorithms. This design approach was selected to provide future NASA science missions with the greatest value in mission performance benefit at a low total development cost. The objective of the HIVHAC task is to advance the Hall thruster technology readiness for science mission applications. The task seeks to increase specific impulse, throttle-ability and lifetime to make Hall propulsion systems applicable to deep space science missions. The primary application focus for the resulting Hall propulsion system would be cost-capped missions, such as competitively selected, Discovery-class missions. The objective of the advanced xenon feed system task is to demonstrate novel manufacturing techniques that will significantly reduce mass, volume, and footprint size of xenon feed systems over conventional feed systems. This task has focused on the development of a flow control module, which consists of a three-channel flow system based on a piezo-electrically actuated

Overview of GX launch services by GALEX

Science.gov (United States)

Sato, Koji; Kondou, Yoshirou

2006-07-01

Galaxy Express Corporation (GALEX) is a launch service company in Japan to develop a medium size rocket, GX rocket and to provide commercial launch services for medium/small low Earth orbit (LEO) and Sun synchronous orbit (SSO) payloads with a future potential for small geo-stationary transfer orbit (GTO). It is GALEX's view that small/medium LEO/SSO payloads compose of medium scaled but stable launch market due to the nature of the missions. GX rocket is a two-stage rocket of well flight proven liquid oxygen (LOX)/kerosene booster and LOX/liquid natural gas (LNG) upper stage. This LOX/LNG propulsion under development by Japan's Aerospace Exploration Agency (JAXA), is robust with comparable performance as other propulsions and have future potential for wider application such as exploration programs. GX rocket is being developed through a joint work between the industries and GX rocket is applying a business oriented approach in order to realize competitive launch services for which well flight proven hardware and necessary new technology are to be introduced as much as possible. It is GALEX's goal to offer “Easy Access to Space”, a highly reliable and user-friendly launch services with a competitive price. GX commercial launch will start in Japanese fiscal year (JFY) 2007 2008.

Radioisotope electric propulsion for robotic science missions to near-interstellar space

International Nuclear Information System (INIS)

Noble, R.J.

1994-10-01

The use of radioisotope electric propulsion for sending small robotic probes on fast science missions several hundred astronomical units (AU) from the Sun is investigated. Such missions would address a large variety of solar, interstellar, galactic and cosmological science themes from unique vantage points at 100 to 600 AU, including parallax distance measurements for the entire Milky Way Galaxy, sampling of the interstellar medium and imaging of cosmological objects at the gravitational lens foci of the Sun (≥ 550 AU). Radioisotope electric propulsion (REP) systems are low-thrust, ion propulsion units based on multi-hundred watt, radioisotope electric generators and ion thrusters. In a previous work, the flight times for rendezvous missions to the outer planets (< 30 AU) using REP were found to be less than fifteen years. However fast prestellar missions to several hundred AU are not possible unless the probe's energy can be substantially increased in the inner Solar System so as to boost the final hyperbolic excess velocity. In this paper an economical hybrid propulsion scheme combining chemical propulsion and gravity assist in the inner Solar System and radioisotope electric propulsion in the outer Solar System is studied which enables fast prestellar missions. Total hyperbolic excess velocities of 15 AU/year and flight times to 550 AU of about 40 years are possible using REP technology that may be available in the next decade

Optimization of extended propulsion time nuclear-electric propulsion trajectories

Science.gov (United States)

Sauer, C. G., Jr.

1981-01-01

This paper presents the methodology used in optimizing extended propulsion time NEP missions considering realistic thruster lifetime constraints. These missions consist of a powered spiral escape from a 700-km circular orbit at the earth, followed by a powered heliocentric transfer with an optimized coast phase, and terminating in a spiral capture phase at the target planet. This analysis is most applicable to those missions with very high energy requirements such as outer planet orbiter missions or sample return missions where the total propulsion time could greatly exceed the expected lifetime of an individual thruster. This methodology has been applied to the investigation of NEP missions to the outer planets where examples are presented of both constrained and optimized trajectories.

Breakthrough Propulsion Physics Project: Project Management Methods

Science.gov (United States)

Millis, Marc G.

2004-01-01

To leap past the limitations of existing propulsion, the NASA Breakthrough Propulsion Physics (BPP) Project seeks further advancements in physics from which new propulsion methods can eventually be derived. Three visionary breakthroughs are sought: (1) propulsion that requires no propellant, (2) propulsion that circumvents existing speed limits, and (3) breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis is to identify credible research that will make measurable progress toward these goals in the near-term. The management techniques to address this challenge are presented, with a special emphasis on the process used to review, prioritize, and select research tasks. This selection process includes these key features: (a) research tasks are constrained to only address the immediate unknowns, curious effects or critical issues, (b) reliability of assertions is more important than the implications of the assertions, which includes the practice where the reviewers judge credibility rather than feasibility, and (c) total scores are obtained by multiplying the criteria scores rather than by adding. Lessons learned and revisions planned are discussed.

An Overview of Cube-Satellite Propulsion Technologies and Trends

Directory of Open Access Journals (Sweden)

Akshay Reddy Tummala

2017-12-01

Full Text Available CubeSats provide a cost effective means to perform scientific and technological studies in space. Due to their affordability, CubeSat technologies have been diversely studied and developed by educational institutions, companies and space organizations all over the world. The CubeSat technology that is surveyed in this paper is the propulsion system. A propulsion system is the primary mobility device of a spacecraft and helps with orbit modifications and attitude control. This paper provides an overview of micro-propulsion technologies that have been developed or are currently being developed for CubeSats. Some of the micro-propulsion technologies listed have also flown as secondary propulsion systems on larger spacecraft. Operating principles and key design considerations for each class of propulsion system are outlined. Finally, the performance factors of micro-propulsion systems have been summarized in terms of: first, a comparison of thrust and specific impulse for all propulsion systems; second, a comparison of power and specific impulse, as also thrust-to-power ratio and specific impulse for electric propulsion systems.

Concept designs for NASA's Solar Electric Propulsion Technology Demonstration Mission

Science.gov (United States)

Mcguire, Melissa L.; Hack, Kurt J.; Manzella, David H.; Herman, Daniel A.

2014-01-01

Multiple Solar Electric Propulsion Technology Demonstration Mission were developed to assess vehicle performance and estimated mission cost. Concepts ranged from a 10,000 kilogram spacecraft capable of delivering 4000 kilogram of payload to one of the Earth Moon Lagrange points in support of future human-crewed outposts to a 180 kilogram spacecraft capable of performing an asteroid rendezvous mission after launched to a geostationary transfer orbit as a secondary payload. Low-cost and maximum Delta-V capability variants of a spacecraft concept based on utilizing a secondary payload adapter as the primary bus structure were developed as were concepts designed to be co-manifested with another spacecraft on a single launch vehicle. Each of the Solar Electric Propulsion Technology Demonstration Mission concepts developed included an estimated spacecraft cost. These data suggest estimated spacecraft costs of $200 million - $300 million if 30 kilowatt-class solar arrays and the corresponding electric propulsion system currently under development are used as the basis for sizing the mission concept regardless of launch vehicle costs. The most affordable mission concept developed based on subscale variants of the advanced solar arrays and electric propulsion technology currently under development by the NASA Space Technology Mission Directorate has an estimated cost of $50M and could provide a Delta-V capability comparable to much larger spacecraft concepts.

A physiological and biomechanical comparison of over-ground, treadmill and ergometer wheelchair propulsion.

Science.gov (United States)

Mason, Barry; Lenton, John; Leicht, Christof; Goosey-Tolfrey, Victoria

2014-01-01

The purpose of the study was to determine which laboratory-based modality provides the most valid physiological and biomechanical representation of over-ground sports wheelchair propulsion. Fifteen able-bodied participants with previous experience of wheelchair propulsion performed a 3-minute exercise trial at three speeds (4, 6 and 8 km ∙ h(-1)) in three testing modalities over separate sessions: (i) over-ground propulsion on a wooden sprung surface; (ii) wheelchair ergometer propulsion; (iii) treadmill propulsion at four different gradients (0%, 0.7%, 1.0% and 1,3%). A 0.7% treadmill gradient was shown to best reflect the oxygen uptake (7.3 to 9.1% coefficient of variation (CV)) and heart rate responses (4.9 to 6.4% CV) of over-ground propulsion at 4 and 6 km ∙ h(-1). A 1.0% treadmill gradient provided a more valid representation of oxygen uptake during over-ground propulsion at 8 km ∙ h(-1) (8.6% CV). Physiological demand was significantly underestimated in the 0% gradient and overestimated in the 1.3% gradient and wheelchair ergometer trials compared to over-ground trials (Ppropulsion at lower speeds (4 and 6 km ∙ h(-1)) whereas a 1.0% gradient may be more suitable at 8 km ∙ h(-1).

Propulsion of liposomes using bacterial motors

International Nuclear Information System (INIS)

Zhang Zhenhai; Li Kejie; Li Zhifei; Yu Wei; Xie Zhihong; Shi Zhiguo

2013-01-01

Here we describe the utilization of flagellated bacteria as actuators to propel spherical liposomes by attaching bacteria to the liposome surface. Bacteria were stably attached to liposomes using a cross-linking antibody. The effect of the number of attached bacteria on propulsion speed was experimentally determined. The effects of bacterial propulsion on the bacteria–antibody–liposome complex were stochastic. We demonstrated that liposomal mobility increased when bacteria were attached, and the propulsion speed correlated with the number of bacteria. (paper)

Development of Propulsion Inverter Control System for High-Speed Maglev based on Long Stator Linear Synchronous Motor

Directory of Open Access Journals (Sweden)

Jeong-Min Jo

2017-02-01

Full Text Available In the case of a long-stator linear drive, unlike rotative drives for which speed or position sensors are a single unit attached to the shaft, these sensors extend along the guideway. The position signals transmitted from a maglev vehicle cannot meet the need of the real-time propulsion control in the on-ground inverter power substations. In this paper the design of the propulsion inverter control system with a position estimator for driving a long-stator synchronous motor in a high-speed maglev train is proposed. The experiments have been carried out at the 150 m long guideway at the O-song test track. To investigate the performance of the position estimator, the propulsion control system with, and without, the position estimator are compared. The result confirms that the proposed strategy can meet the dynamic property needs of the propulsion inverter control system for driving long-stator linear synchronous motors.

Exotic power and propulsion concepts

International Nuclear Information System (INIS)

Forward, R.L.

1990-01-01

The status of some exotic physical phenomena and unconventional spacecraft concepts that might produce breakthroughs in power and propulsion in the 21st Century are reviewed. The subjects covered include: electric, nuclear fission, nuclear fusion, antimatter, high energy density materials, metallic hydrogen, laser thermal, solar thermal, solar sail, magnetic sail, and tether propulsion

Operationally efficient propulsion system study (OEPSS) data book. Volume 6; Space Transfer Propulsion Operational Efficiency Study Task of OEPSS

Science.gov (United States)

Harmon, Timothy J.

1992-01-01

This document is the final report for the Space Transfer Propulsion Operational Efficiency Study Task of the Operationally Efficient Propulsion System Study (OEPSS) conducted by the Rocketdyne Division of Rockwell International. This Study task studied, evaluated and identified design concepts and technologies which minimized launch and in-space operations and optimized in-space vehicle propulsion system operability.

Nuclear propulsion: to go to the moon in 24 hours; Propulsion nucleaire: aller sur la lune en 24 heures

Energy Technology Data Exchange (ETDEWEB)

Freeman, M

1999-10-01

Nuclear propulsion is a necessary step to give to man the opportunity of developing activities in space. This technique enables rockets to go farther, more quickly and to transport more load than the classical chemical propulsion. Space travel requires huge quantities of energy. An equivalent quantity of energy can be extracted from 13 tons of liquid hydrogen-oxygen, from 20 g of uranium (fission), from 0.5 g of deuterium (fusion) and from 0.02 g of anti-hydrogen-hydrogen (annihilation). The concept of nuclear thermal rocket (NTR) is based on an embarked nuclear reactor whose purpose is to heat hydrogen to 3000 K temperature. The thrust can be increased by injecting liquid oxygen in the nozzle to react with supersonic hydrogen. (A.C.)

Main Propulsion Test Article (MPTA)

Science.gov (United States)

Snoddy, Cynthia

2010-01-01

Scope: The Main Propulsion Test Article integrated the main propulsion subsystem with the clustered Space Shuttle Main Engines, the External Tank and associated GSE. The test program consisted of cryogenic tanking tests and short- and long duration static firings including gimbaling and throttling. The test program was conducted on the S1-C test stand (Position B-2) at the National Space Technology Laboratories (NSTL)/Stennis Space Center. 3 tanking tests and 20 hot fire tests conducted between December 21 1 1977 and December 17, 1980 Configuration: The main propulsion test article consisted of the three space shuttle main engines, flightweight external tank, flightweight aft fuselage, interface section and a boilerplate mid/fwd fuselage truss structure.

NASA's Nuclear Thermal Propulsion Project

Science.gov (United States)

Houts, Michael G.; Mitchell, Doyce P.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Clement, Steven; Borowski, Stanley K.;

Design of an Electric Propulsion System for SCEPTOR

Science.gov (United States)

Dubois, Arthur; van der Geest, Martin; Bevirt, JoeBen; Clarke, Sean; Christie, Robert J.; Borer, Nicholas K.

2016-01-01

The rise of electric propulsion systems has pushed aircraft designers towards new and potentially transformative concepts. As part of this effort, NASA is leading the SCEPTOR program which aims at designing a fully electric distributed propulsion general aviation aircraft. This article highlights critical aspects of the design of SCEPTOR's propulsion system conceived at Joby Aviation in partnership with NASA, including motor electromagnetic design and optimization as well as cooling system integration. The motor is designed with a finite element based multi-objective optimization approach. This provides insight into important design tradeoffs such as mass versus efficiency, and enables a detailed quantitative comparison between different motor topologies. Secondly, a complete design and Computational Fluid Dynamics analysis of the air breathing cooling system is presented. The cooling system is fully integrated into the nacelle, contains little to no moving parts and only incurs a small drag penalty. Several concepts are considered and compared over a range of operating conditions. The study presents trade-offs between various parameters such as cooling efficiency, drag, mechanical simplicity and robustness.

Propulsive options for a manned Mars transportation system

International Nuclear Information System (INIS)

Braun, R.D.; Blersch, D.J.

1989-01-01

In this investigation, five potential manned Mars transportation systems are compared. These options include: (1) a single vehicle, chemically propelled (CHEM) option, (2) a single vehicle, nuclear thermal propulsion (NTP) option, (3) a single vehicle solar electric propulsion (SEP) option, (4) a single vehicle hybrid nuclear electric propulsion (NEP)/CHEM option, and (5) a dual vehicle option (NEP cargo spacecraft and CHEM manned vehicle). In addition to utilizing the initial vehicle weight in low-earth orbit as a measure of mission feasibility, this study addresses the major technological barriers each propulsive scenario must surpass. It is shown that instead of a single clearly superior propulsion system, each means of propulsion may be favored depending upon the specified program policy and the extent of the desired manned flight time. Furthermore, the effect which aerobraking and multiple transfer cycles have upon mission feasibility is considered. 18 refs

Concept Design and Risk Assessment of Nuclear Propulsion Ship

International Nuclear Information System (INIS)

Gil, Youngmi; Yoo, Seongjin; Kim, Yeontae; Oh, June; Byun, Yoonchul; Woo, Ilguk; Kim, Jiho; Choi, Suhn

2014-01-01

The nuclear propulsion ships (hereinafter referred to as 'nuclear ships') have been considered as an eco-friendly ship. There have historically been warship and submarine with the source of nuclear power. The use of nuclear ships has been recently extending to the icebreaker, the deep-water exploration ship, and the floating nuclear power plant. Prior to developing the new ship, we evaluated the economics of various types of ships and concluded that the container ship could be appropriate for the nuclear propulsion. In order to verify its safety, we performed the ship calculation based on the optimal arrangement of the nuclear reactor. Finally, we verified its safety by the HAZID. In the former research, we confirmed the applicability of the nuclear propulsion system for the large container ship. In this study, we verified the safety of the nuclear ships according to the HAZID analysis. We expect that this research will lead to safe design of the nuclear ships

Concept Design and Risk Assessment of Nuclear Propulsion Ship

Energy Technology Data Exchange (ETDEWEB)

Gil, Youngmi; Yoo, Seongjin; Kim, Yeontae; Oh, June; Byun, Yoonchul; Woo, Ilguk [Daewoo Shipbuilding and Marine Engineering Co. Ltd., Seoul (Korea, Republic of); Kim, Jiho; Choi, Suhn [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2014-05-15

The nuclear propulsion ships (hereinafter referred to as 'nuclear ships') have been considered as an eco-friendly ship. There have historically been warship and submarine with the source of nuclear power. The use of nuclear ships has been recently extending to the icebreaker, the deep-water exploration ship, and the floating nuclear power plant. Prior to developing the new ship, we evaluated the economics of various types of ships and concluded that the container ship could be appropriate for the nuclear propulsion. In order to verify its safety, we performed the ship calculation based on the optimal arrangement of the nuclear reactor. Finally, we verified its safety by the HAZID. In the former research, we confirmed the applicability of the nuclear propulsion system for the large container ship. In this study, we verified the safety of the nuclear ships according to the HAZID analysis. We expect that this research will lead to safe design of the nuclear ships.

Comparing handrim biomechanics for treadmill and overground wheelchair propulsion

Science.gov (United States)

Kwarciak, Andrew M.; Turner, Jeffrey T.; Guo, Liyun; Richter, W. Mark

2010-01-01

Study design Cross-sectional study. Objectives To compare handrim biomechanics recorded during overground propulsion to those recorded during propulsion on a motor-driven treadmill. Setting Biomechanics laboratory. Methods Twenty-eight manual wheelchair users propelled their own wheelchairs, at a self-selected speed, on a low-pile carpet and on a wheelchair accessible treadmill. Handrim biomechanics were recorded with an OptiPush instrumented wheelchair wheel. Results Across the two conditions, all handrim biomechanics were found to be similar and highly correlated (r > 0.85). Contact angle, peak force, average force, and peak axle moment differed by 1.6% or less across the two conditions. While not significant, power output and cadence tended to be slightly higher for the treadmill condition (3.5% and 3.6%, respectively), due to limitations in adjusting the treadmill grade. Conclusion Based on the results of this study, a motor-driven treadmill can serve as a valid surrogate for overground studies of wheelchair propulsion. PMID:21042332

Improved CVD Coatings for Carbide Based Nuclear Thermal Propulsion Fuel Elements, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — One of the great hurdles to further development and evaluation of nuclear thermal propulsion systems is the issue surrounding the release of radioactive material...

A novel nuclear-powered propulsion system for ship

International Nuclear Information System (INIS)

Liu Tao; Han Weishi

2003-01-01

A novel nuclear-powered propulsion system for ship is presented in this paper. In this system, a minitype liquid sodium-cooled reactor is used as power; alkali-metal thermal-to-electric conversion (AMTEC) cells are utilized to transform the heat energy to electric energy and superconducting magneto-hydrodynamic (MHD) work as propulsion. This nuclear-powered propulsion system has great advantages in low noise, high speed, long survivability and simple manipulation. It has great significance for the development of propulsion system. (author)

Center for Advanced Space Propulsion Second Annual Technical Symposium Proceedings

Science.gov (United States)

1990-01-01

The proceedings for the Center for Advanced Space Propulsion Second Annual Technical Symposium are divided as follows: Chemical Propulsion, CFD; Space Propulsion; Electric Propulsion; Artificial Intelligence; Low-G Fluid Management; and Rocket Engine Materials.

Improving the performance of LOX/kerosene upper stage rocket engines

Directory of Open Access Journals (Sweden)

IgorN. Nikischenko

2017-09-01

Full Text Available Improved liquid rocket engine cycles were proposed and analyzed via comparison with existing staged combustion and gas-generator cycles. The key features of the proposed cycles are regenerative cooling of thrust chamber by oxygen and subsequent use of this oxygen for driving one or two oxygen pumps. The fuel pump(s are driven in a conventional manner, for example, using a fuel-rich gas-generator cycle. Comparison with staged combustion cycle based on oxygen-rich pre-burner showed that one of the proposed semi-expander cycles has a specific impulse only on 0.4% lower while providing much lower oxygen temperature, more efficient tank pressurizing system and built-in roll control. This semi-expander cycle can be considered as a more reliable and cost-effective alternative of staged combustion cycle. Another semi-expander cycle can be considered as an improvement of gas-generator cycle. All proposed semi-expander cycles were developed as a derivative of thrust chamber regenerative cooling performed by oxygen. Analysis of existing oxygen/kerosene engines showed that replacing of kerosene regenerative cooling with oxygen allows a significant increase of achievable specific impulse, via optimization of mixture ratio. It is especially the case for upper stage engines. The increasing of propellants average density can be considered as an additional benefit of mixture ratio optimization. It was demonstrated that oxygen regenerative cooling of thrust chamber is a feasible and the most promising option for oxygen/kerosene engines. Combination of oxygen regenerative cooling and semi-expander cycles potentially allows creating the oxygen/kerosene propulsion systems with minimum specific impulse losses. It is important that such propulsion systems can be fully based on inherited and well-proven technical solutions. A hypothetic upper stage engine with thrust 19.6 kN was chosen as a prospective candidate for theoretical analysis of the proposed semi

Phase 1 space fission propulsion system design considerations

International Nuclear Information System (INIS)

Houts, Mike; Van Dyke, Melissa; Godfroy, Tom; Pedersen, Kevin; Martin, James; Dickens, Ricky; Salvail, Pat; Hrbud, Ivana; Carter, Robert

2002-01-01

Fission technology can enable rapid, affordable access to any point in the solar system. If fission propulsion systems are to be developed to their full potential; however, near-term customers must be identified and initial fission systems successfully developed, launched, and operated. Studies conducted in fiscal year 2001 (IISTP, 2001) show that fission electric propulsion (FEP) systems operating at 80 kWe or above could enhance or enable numerous robotic outer solar system missions of interest. At these power levels it is possible to develop safe, affordable systems that meet mission performance requirements. In selecting the system design to pursue, seven evaluation criteria were identified: safety, reliability, testability, specific mass, cost, schedule, and programmatic risk. A top-level comparison of three potential concepts was performed: an SP-100 based pumped liquid lithium system, a direct gas cooled system, and a heatpipe cooled system. For power levels up to at least 500 kWt (enabling electric power levels of 125-175 kWe, given 25-35% power conversion efficiency) the heatpipe system has advantages related to several criteria and is competitive with respect to all. Hardware-based research and development has further increased confidence in the heatpipe approach. Successful development and utilization of a 'Phase 1' fission electric propulsion system will enable advanced Phase 2 and Phase 3 systems capable of providing rapid, affordable access to any point in the solar system

An Investigation of Bilateral Symmetry During Manual Wheelchair Propulsion.

Science.gov (United States)

Soltau, Shelby L; Slowik, Jonathan S; Requejo, Philip S; Mulroy, Sara J; Neptune, Richard R

2015-01-01

Studies of manual wheelchair propulsion often assume bilateral symmetry to simplify data collection, processing, and analysis. However, the validity of this assumption is unclear. Most investigations of wheelchair propulsion symmetry have been limited by a relatively small sample size and a focus on a single propulsion condition (e.g., level propulsion at self-selected speed). The purpose of this study was to evaluate bilateral symmetry during manual wheelchair propulsion in a large group of subjects across different propulsion conditions. Three-dimensional kinematics and handrim kinetics along with spatiotemporal variables were collected and processed from 80 subjects with paraplegia while propelling their wheelchairs on a stationary ergometer during three different conditions: level propulsion at their self-selected speed (free), level propulsion at their fastest comfortable speed (fast), and propulsion on an 8% grade at their level, self-selected speed (graded). All kinematic variables had significant side-to-side differences, primarily in the graded condition. Push angle was the only spatiotemporal variable with a significant side-to-side difference, and only during the graded condition. No kinetic variables had significant side-to-side differences. The magnitudes of the kinematic differences were low, with only one difference exceeding 5°. With differences of such small magnitude, the bilateral symmetry assumption appears to be reasonable during manual wheelchair propulsion in subjects without significant upper-extremity pain or impairment. However, larger asymmetries may exist in individuals with secondary injuries and pain in their upper extremity and different etiologies of their neurological impairment.

An overview of the NASA Advanced Propulsion Concepts program

International Nuclear Information System (INIS)

Curran, F.M.; Bennett, G.L.; Frisbee, R.H.; Sercel, J.C.; Lapointe, M.R.

1992-07-01

NASA Advanced Propulsion Concepts (APC) program for the development of long-term space propulsion system schemes is managed by both NASA-Lewis and the JPL and is tasked with the identification and conceptual development of high-risk/high-payoff configurations. Both theoretical and experimental investigations have been undertaken in technology areas deemed essential to the implementation of candidate concepts. These APC candidates encompass very high energy density chemical propulsion systems, advanced electric propulsion systems, and an antiproton-catalyzed nuclear propulsion concept. A development status evaluation is presented for these systems. 45 refs

Experimental Methods for UAV Aerodynamic and Propulsion Performance Assessment

Directory of Open Access Journals (Sweden)

Stefan ANTON

2015-06-01

Full Text Available This paper presents an experimental method for assessing the performances and the propulsion power of a UAV in several points based on telemetry. The points in which we make the estimations are chosen based on several criteria and the fallowing parameters are measured: airspeed, time-to-climb, altitude and the horizontal distance. With the estimated propulsion power and knowing the shaft motor power, the propeller efficiency is determined at several speed values. The shaft motor power was measured in the lab using the propeller as a break. Many flights, using the same UAV configuration, were performed before extracting flight data, in order to reduce the instrumental or statistic errors. This paper highlights both the methodology of processing the data and the validation of theoretical results.

46 CFR 121.620 - Propulsion engine control systems.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Propulsion engine control systems. 121.620 Section 121... Propulsion engine control systems. (a) A vessel must have two independent means of controlling each propulsion engine. Control must be provided for the engine speed, direction of shaft rotation, and engine...

High-Power Hall Propulsion Development at NASA Glenn Research Center

Science.gov (United States)

Kamhawi, Hani; Manzella, David H.; Smith, Timothy D.; Schmidt, George R.

2014-01-01

The NASA Office of the Chief Technologist Game Changing Division is sponsoring the development and testing of enabling technologies to achieve efficient and reliable human space exploration. High-power solar electric propulsion has been proposed by NASA's Human Exploration Framework Team as an option to achieve these ambitious missions to near Earth objects. NASA Glenn Research Center (NASA Glenn) is leading the development of mission concepts for a solar electric propulsion Technical Demonstration Mission. The mission concepts are highlighted in this paper but are detailed in a companion paper. There are also multiple projects that are developing technologies to support a demonstration mission and are also extensible to NASA's goals of human space exploration. Specifically, the In-Space Propulsion technology development project at NASA Glenn has a number of tasks related to high-power Hall thrusters including performance evaluation of existing Hall thrusters; performing detailed internal discharge chamber, near-field, and far-field plasma measurements; performing detailed physics-based modeling with the NASA Jet Propulsion Laboratory's Hall2De code; performing thermal and structural modeling; and developing high-power efficient discharge modules for power processing. This paper summarizes the various technology development tasks and progress made to date

Deployable Propulsion, Power and Communications Systems for Solar System Exploration

Science.gov (United States)

Johnson, L.; Carr, J.; Boyd, D.

2017-01-01

NASA is developing thin-film based, deployable propulsion, power, and communication systems for small spacecraft that could provide a revolutionary new capability allowing small spacecraft exploration of the solar system. By leveraging recent advancements in thin films, photovoltaics, and miniaturized electronics, new mission-level capabilities will be enabled aboard lower-cost small spacecraft instead of their more expensive, traditional counterparts, enabling a new generation of frequent, inexpensive deep space missions. Specifically, thin-film technologies are allowing the development and use of solar sails for propulsion, small, lightweight photovoltaics for power, and omnidirectional antennas for communication.

Monofilament Vaporization Propulsion (MVP) System, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Monofilament Vaporization Propulsion (MVP) is a new propulsion technology targeted at secondary payload applications. It does not compromise on performance while...

Energy Based Control System Designs for Underactuated Robot Fish Propulsion

OpenAIRE

Roper, Daniel

2013-01-01

In nature through millions of years of evolution fish and cetaceans have developed fast efficient and highly manoeuvrable methods of marine propulsion. A recent explosion in demand for sub sea robotics, for conducting tasks such as sub sea exploration and survey has left developers desiring to capture some of the novel mechanisms evolved by fish and cetaceans to increase the efficiency of speed and manoeuvrability of sub sea robots. Research has revealed that interactions with...

Relationship between shoulder roll and hand propulsion in the front crawl stroke.

Science.gov (United States)

Kudo, Shigetada; Sakurai, Yoshihisa; Miwa, Takahiro; Matsuda, Yuji

2017-05-01

This study re-evaluated the magnitude of hand propulsion (HP) in the pull and push phases of the front crawl stroke and investigated the association between the angular velocity of shoulder roll (ω SR ) and hand propulsive lift (HP L ). ω SR was computed in the plane normal to a forward direction for 16 skilled swimmers performing the front crawl stroke at a maximal sprinting pace. HP, hand propulsive drag (HP D ) and HP L were determined by a dynamic pressure approach. HP and HP D in the pull phase were greater than in the push phase (P push phase. Eleven swimmers out of the 16 swimmers had a significant within-swimmers correlation between ω SR and HP L in the push phase (P push phase as the ω SR of rolling back to the neutral position became faster. A swimmer should use more drag for hand propulsion in the pull phase and propulsion from drag and lift equally in the push phase. Based on the relationship between ω SR and HP L in the push phase, a possible stroke technique to enhance HP L using ω SR is discussed.

46 CFR 184.620 - Propulsion engine control systems.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Propulsion engine control systems. 184.620 Section 184... Communications Systems § 184.620 Propulsion engine control systems. (a) A vessel must have two independent means of controlling each propulsion engine. Control must be provided for the engine speed, direction of...

In-Space Propulsion Technologies for Robotic Exploration of the Solar System

Science.gov (United States)

Johnson, Les; Meyer, Rae Ann; Frame, Kyle

2006-01-01

Supporting NASA's Science Mission Directorate, the In-Space Propulsion Technology Program is developing the next generation of space propulsion technologies for robotic, deep-space exploration. Recent technological advancements and demonstrations of key, high-payoff propulsion technologies have been achieved and will be described. Technologies under development and test include aerocapture, solar electric propulsion, solar sail propulsion, and advanced chemical propulsion.

Modifications in Wheelchair Propulsion Technique with Speed.

Science.gov (United States)

Russell, Ian M; Raina, Shashank; Requejo, Philip S; Wilcox, Rand R; Mulroy, Sara; McNitt-Gray, Jill L

2015-01-01

Repetitive loading of the upper limb joints during manual wheelchair (WC) propulsion (WCP) has been identified as a factor that contributes to shoulder pain, leading to loss of independence and decreased quality of life. The purpose of this study was to determine how individual manual WC users with paraplegia modify propulsion mechanics to accommodate expected increases in reaction forces (RFs) generated at the pushrim with self-selected increases in WCP speed. Upper extremity kinematics and pushrim RFs were measured for 40 experienced manual WC users with paraplegia while propelling on a stationary ergometer at self-selected free and fast propulsion speeds. Upper extremity kinematics and kinetics were compared within subject between propulsion speeds. Between group and within-subject differences were determined (α = 0.05). Increased propulsion speed was accompanied by increases in RF magnitude (22 of 40, >10 N) and shoulder net joint moment (NJM, 15 of 40, >10 Nm) and decreases in pushrim contact duration. Within-subject comparison indicated that 27% of participants modified their WCP mechanics with increases in speed by regulating RF orientation relative to the upper extremity segments. Reorientation of the RF relative to the upper extremity segments can be used as an effective strategy for mitigating rotational demands (NJM) imposed on the shoulder at increased propulsion speeds. Identification of propulsion strategies that individuals can use to effectively accommodate for increases in RFs is an important step toward preserving musculoskeletal health of the shoulder and improving health-related quality of life.

Beamed-Energy Propulsion (BEP) Study

Science.gov (United States)

George, Patrick; Beach, Raymond

2012-01-01

The scope of this study was to (1) review and analyze the state-of-art in beamed-energy propulsion (BEP) by identifying potential game-changing applications, (2) formulate a roadmap of technology development, and (3) identify key near-term technology demonstrations to rapidly advance elements of BEP technology to Technology Readiness Level (TRL) 6. The two major areas of interest were launching payloads and space propulsion. More generally, the study was requested and structured to address basic mission feasibility. The attraction of beamed-energy propulsion (BEP) is the potential for high specific impulse while removing the power-generation mass. The rapid advancements in high-energy beamed-power systems and optics over the past 20 years warranted a fresh look at the technology. For launching payloads, the study concluded that using BEP to propel vehicles into space is technically feasible if a commitment to develop new technologies and large investments can be made over long periods of time. From a commercial competitive standpoint, if an advantage of beamed energy for Earth-to-orbit (ETO) is to be found, it will rest with smaller, frequently launched payloads. For space propulsion, the study concluded that using beamed energy to propel vehicles from low Earth orbit to geosynchronous Earth orbit (LEO-GEO) and into deep space is definitely feasible and showed distinct advantages and greater potential over current propulsion technologies. However, this conclusion also assumes that upfront infrastructure investments and commitments to critical technologies will be made over long periods of time. The chief issue, similar to that for payloads, is high infrastructure costs.

A Novel UAV Electric Propulsion Testbed for Diagnostics and Prognostics

Science.gov (United States)

Gorospe, George E., Jr.; Kulkarni, Chetan S.

2017-01-01

This paper presents a novel hardware-in-the-loop (HIL) testbed for systems level diagnostics and prognostics of an electric propulsion system used in UAVs (unmanned aerial vehicle). Referencing the all electric, Edge 540T aircraft used in science and research by NASA Langley Flight Research Center, the HIL testbed includes an identical propulsion system, consisting of motors, speed controllers and batteries. Isolated under a controlled laboratory environment, the propulsion system has been instrumented for advanced diagnostics and prognostics. To produce flight like loading on the system a slave motor is coupled to the motor under test (MUT) and provides variable mechanical resistance, and the capability of introducing nondestructive mechanical wear-like frictional loads on the system. This testbed enables the verification of mathematical models of each component of the propulsion system, the repeatable generation of flight-like loads on the system for fault analysis, test-to-failure scenarios, and the development of advanced system level diagnostics and prognostics methods. The capabilities of the testbed are extended through the integration of a LabVIEW-based client for the Live Virtual Constructive Distributed Environment (LVCDC) Gateway which enables both the publishing of generated data for remotely located observers and prognosers and the synchronization the testbed propulsion system with vehicles in the air. The developed HIL testbed gives researchers easy access to a scientifically relevant portion of the aircraft without the overhead and dangers encountered during actual flight.

Advanced Chemical Propulsion for Science Missions

Science.gov (United States)

Liou, Larry

2008-01-01

The advanced chemical propulsion technology area of NASA's In-Space Technology Project is investing in systems and components for increased performance and reduced cost of chemical propulsion technologies applicable to near-term science missions. Presently the primary investment in the advanced chemical propulsion technology area is in the AMBR high temperature storable bipropellant rocket engine. Scheduled to be available for flight development starting in year 2008, AMBR engine shows a 60 kg payload gain in an analysis for the Titan-Enceladus orbiter mission and a 33 percent manufacturing cost reduction over its baseline, state-of-the-art counterpart. Other technologies invested include the reliable lightweight tanks for propellant and the precision propellant management and mixture ratio control. Both technologies show significant mission benefit, can be applied to any liquid propulsion system, and upon completion of the efforts described in this paper, are at least in parts ready for flight infusion. Details of the technologies are discussed.

Possible configurations for an air independent propulsion (AIP) system for submarines based on fuel cells

International Nuclear Information System (INIS)

Bordallo, C.R.; Moreno, E.; Brey, J.J.; Garcia, C.; Sarmiento, B.; Castro, A.

2004-01-01

'Full text:' Conventional submarines employ an electric propulsion system, based on energy storage in batteries which are recharged using diesel motors connected to generator alternators. This limits their autonomy underwater given that it will be depend on the amount of energy that can be stored in the batteries; currently, a normal value is to have energy to navigate for three days at low speed. As of from the WWII, several shipyards began to carry out research on propulsion systems for submarines that would be capable of operating under anaerobic conditions, independent of the air (AIP Systems). Since then, several proposals have been considered, but there is one option that several navies are currently putting their trust in: fuel cells. The objective of this Project is to stress the different configurations that can be considered to this end, as regards the transportation of hydrogen and oxygen. From the hydrogen point of view, the possibilities of transporting it in metal hydrides or its on-board production through the reforming of different fuels (gas-oil, ethanol, methanol), are analyzed. This study also compares auxiliary systems (including CO2 removers), and proposes solutions, some of which are under development, indicating which are currently being considered to a greater extent. (author)

Possible configurations for an air independent propulsion (AIP) system for submarines based on fuel cells

Energy Technology Data Exchange (ETDEWEB)

Bordallo, C.R.; Moreno, E.; Brey, J.J.; Garcia, C.; Sarmiento, B.; Castro, A. [Hynergreen Technologies, S.A., Seville (Spain)

2004-07-01

'Full text:' Conventional submarines employ an electric propulsion system, based on energy storage in batteries which are recharged using diesel motors connected to generator alternators. This limits their autonomy underwater given that it will be depend on the amount of energy that can be stored in the batteries; currently, a normal value is to have energy to navigate for three days at low speed. As of from the WWII, several shipyards began to carry out research on propulsion systems for submarines that would be capable of operating under anaerobic conditions, independent of the air (AIP Systems). Since then, several proposals have been considered, but there is one option that several navies are currently putting their trust in: fuel cells. The objective of this Project is to stress the different configurations that can be considered to this end, as regards the transportation of hydrogen and oxygen. From the hydrogen point of view, the possibilities of transporting it in metal hydrides or its on-board production through the reforming of different fuels (gas-oil, ethanol, methanol), are analyzed. This study also compares auxiliary systems (including CO2 removers), and proposes solutions, some of which are under development, indicating which are currently being considered to a greater extent. (author)

Propulsion controlled aircraft computer

Science.gov (United States)

Cogan, Bruce R. (Inventor)

2010-01-01

A low-cost, easily retrofit Propulsion Controlled Aircraft (PCA) system for use on a wide range of commercial and military aircraft consists of an propulsion controlled aircraft computer that reads in aircraft data including aircraft state, pilot commands and other related data, calculates aircraft throttle position for a given maneuver commanded by the pilot, and then displays both current and calculated throttle position on a cockpit display to show the pilot where to move throttles to achieve the commanded maneuver, or is automatically sent digitally to command the engines directly.

Fluidic electrodynamics: Approach to electromagnetic propulsion

International Nuclear Information System (INIS)

Martins, Alexandre A.; Pinheiro, Mario J.

2009-01-01

We report on a new methodological approach to electrodynamics based on a fluidic viewpoint. We develop a systematic approach establishing analogies between physical magnitudes and isomorphism (structure-preserving mappings) between systems of equations. This methodological approach allows us to give a general expression for the hydromotive force, thus re-obtaining the Navier-Stokes equation departing from the appropriate electromotive force. From this ground we offer a fluidic approach to different kinds of issues with interest in propulsion, e.g., the force exerted by a charged particle on a body carrying current; the magnetic force between two parallel currents; the Magnus's force. It is shown how the intermingle between the fluid vector fields and electromagnetic fields leads to new insights on their dynamics. The new concepts introduced in this work suggest possible applications to electromagnetic (EM) propulsion devices and the mastery of the principles of producing electric fields of required configuration in plasma medium.

Theoretical and FEM analysis of suspension and propulsion system with HTS hybrid electromagnets in an EMS Maglev model

Energy Technology Data Exchange (ETDEWEB)

Chung, Y.D., E-mail: ydchung@suwon.ac.kr [Department of Electrical Engineering, Suwon University, Bongdang Eup, Hwaseong Si 445-743 (Korea, Republic of); Lee, C.Y. [Korea Railroad Research Institute, Woram Dong, Uiwang Si 437-757 (Korea, Republic of); Jang, J.Y. [Department of Electrical Engineering, Ansan College of Technology, Choji-Dong, Ansan Si 425-792 (Korea, Republic of); Yoon, Y.S. [Department of Electrical and Electronic Engineering, Yonsei University, Sinchon-dong, Seoul 120-749 (Korea, Republic of); Ko, T.K. [Department of Electrical Engineering, Ansan College of Technology, Choji-Dong, Ansan Si 425-792 (Korea, Republic of)

2011-11-15

We examine levitation and propulsion forces of the proto-type maglev vehicle system based on 3D FEM. The levitation force increases over 15% due to AC current of the guideway. The levitation force by HTS electromagnet (EM) and AC current is larger over 30% than that of only HTS EM. We have been constructed a proto-type electromagnetic suspension (EMS) based maglev vehicle system. The maglev concept utilizes magnetic forces for noncontact suspension, guidance and propulsion. The suspension system with high temperature superconducting (HTS) hybrid electromagnet (EM) is composed of HTS coils and normal coils, which consume little power to keep large suspension gap. The magnetic forces realize to guide the vehicle, propel the vehicle along the guide-way and assist in braking action. The proto-type EMS-based Maglev model is designed to keep the suspension gap of 20 mm. This paper presents the theoretical analysis of the maglev vehicle based on the EMS model to obtain the designing parameters for levitation and propulsion forces. The magnetic field distributions of the electromagnetic forces with hybrid EM and propulsion stator coils are analyzed based on three dimension (3D) finite element method (FEM) analysis. From the simulation results, appropriately design parameters of the suspension, guidance and propulsion were obtained.

Theoretical and FEM analysis of suspension and propulsion system with HTS hybrid electromagnets in an EMS Maglev model

International Nuclear Information System (INIS)

Chung, Y.D.; Lee, C.Y.; Jang, J.Y.; Yoon, Y.S.; Ko, T.K.

2011-01-01

We examine levitation and propulsion forces of the proto-type maglev vehicle system based on 3D FEM. The levitation force increases over 15% due to AC current of the guideway. The levitation force by HTS electromagnet (EM) and AC current is larger over 30% than that of only HTS EM. We have been constructed a proto-type electromagnetic suspension (EMS) based maglev vehicle system. The maglev concept utilizes magnetic forces for noncontact suspension, guidance and propulsion. The suspension system with high temperature superconducting (HTS) hybrid electromagnet (EM) is composed of HTS coils and normal coils, which consume little power to keep large suspension gap. The magnetic forces realize to guide the vehicle, propel the vehicle along the guide-way and assist in braking action. The proto-type EMS-based Maglev model is designed to keep the suspension gap of 20 mm. This paper presents the theoretical analysis of the maglev vehicle based on the EMS model to obtain the designing parameters for levitation and propulsion forces. The magnetic field distributions of the electromagnetic forces with hybrid EM and propulsion stator coils are analyzed based on three dimension (3D) finite element method (FEM) analysis. From the simulation results, appropriately design parameters of the suspension, guidance and propulsion were obtained.

The effect of wheelchair propulsion style on changes in time spent in extreme wrist orientations after a bout of fatiguing propulsion.

Science.gov (United States)

Zukowski, Lisa A; Hass, Chris J; Shechtman, Orit; Christou, Evangelos A; Tillman, Mark D

2017-10-01

This study compared how wheelchair propulsion styles affect changes in percentage of time spent in extreme wrist orientations, which have been associated with median nerve injury, after a fatiguing bout of propulsion. Twenty novice, non-disabled adult males learned arcing (ARC) and semicircular (SEMI) propulsion styles and utilised each to perform a wheelchair fatigue protocol. ARC and SEMI did not significantly differ in terms of changes after the fatigue protocol in percentage of time spent in extreme flexion/extension or radial/ulnar deviation at the push phase beginning or end. A pattern was observed, although not significant, of greater increases in percentage of time spent in extreme wrist extension and ulnar deviation during the push phase beginning and ulnar deviation during the push phase end while utilising SEMI relative to ARC. This study evinces that individual differences are greater than observed changes in extreme wrist orientations for both propulsion styles. Practitioner Summary: How wheelchair propulsion styles change with fatigue in terms of extreme wrist orientations was examined. This study evinces that individual differences are greater than observed changes in extreme wrist orientations for both propulsion styles and point towards the need for future research on individual differences utilising propulsion styles.

Development of An Intelligent Flight Propulsion Control System

Science.gov (United States)

Calise, A. J.; Rysdyk, R. T.; Leonhardt, B. K.

1999-01-01

The initial design and demonstration of an Intelligent Flight Propulsion and Control System (IFPCS) is documented. The design is based on the implementation of a nonlinear adaptive flight control architecture. This initial design of the IFPCS enhances flight safety by using propulsion sources to provide redundancy in flight control. The IFPCS enhances the conventional gain scheduled approach in significant ways: (1) The IFPCS provides a back up flight control system that results in consistent responses over a wide range of unanticipated failures. (2) The IFPCS is applicable to a variety of aircraft models without redesign and,(3) significantly reduces the laborious research and design necessary in a gain scheduled approach. The control augmentation is detailed within an approximate Input-Output Linearization setting. The availability of propulsion only provides two control inputs, symmetric and differential thrust. Earlier Propulsion Control Augmentation (PCA) work performed by NASA provided for a trajectory controller with pilot command input of glidepath and heading. This work is aimed at demonstrating the flexibility of the IFPCS in providing consistency in flying qualities under a variety of failure scenarios. This report documents the initial design phase where propulsion only is used. Results confirm that the engine dynamics and associated hard nonlineaaities result in poor handling qualities at best. However, as demonstrated in simulation, the IFPCS is capable of results similar to the gain scheduled designs of the NASA PCA work. The IFPCS design uses crude estimates of aircraft behaviour. The adaptive control architecture demonstrates robust stability and provides robust performance. In this work, robust stability means that all states, errors, and adaptive parameters remain bounded under a wide class of uncertainties and input and output disturbances. Robust performance is measured in the quality of the tracking. The results demonstrate the flexibility of

46 CFR 109.555 - Propulsion boilers.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Propulsion boilers. 109.555 Section 109.555 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Miscellaneous § 109.555 Propulsion boilers. The master or person in charge and the engineer in charge shall...

46 CFR 130.120 - Propulsion control.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Propulsion control. 130.120 Section 130.120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS VESSEL CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Vessel Control § 130.120 Propulsion control. (a) Each vessel must have— (1...

Is effective force application in handrim wheelchair propulsion also efficient?

NARCIS (Netherlands)

Bregman, D.J.J.; van Drongelen, S.V.; Veeger, H.E.J.

2009-01-01

Background: Efficiency in manual wheelchair propulsion is low, as is the fraction of the propulsion force that is attributed to the moment of propulsion of the wheelchair. In this study we tested the hypothesis that a tangential propulsion force direction leads to an increase in physiological cost,

Control of Oscillating Foil for Propulsion of Biorobotic Autonomous Underwater Vehicle (AUV

Directory of Open Access Journals (Sweden)

S. N. Singh

2005-01-01

Full Text Available The paper treats the question of control of a laterally and rotationally oscillating hydrofoil for the propulsion of biologically inspired robotic (biorobotic autonomous underwater vehicles (BAUVs. Sinusoidal oscillations of foils produce maneuvering and propulsive forces. The design is based on the internal model principle. Two springs are used to transmit forces from the actuators to the foil. Oscillating fins produce periodic forces, which can be used for fish-like propulsion and control of autonomous underwater vehicles (AUVs. The equations of motion of the foil include hydrodynamic lift and moment based on linear, unsteady, aerodynamic theory. A control law is derived for the lateral and rotational sinusoidal oscillation of the foil. In the closed-loop system, the lateral displacement and the rotational angle of the foil asymptotically follow sinusoidal trajectories of distinct frequencies and amplitudes independently. Simulation results are presented to show the trajectory tracking performance of the foil for different freestream velocities and sinusoidal command trajectories.

Techno-economic investigation of alternative propulsion plants for Ferries and RoRo ships

International Nuclear Information System (INIS)

Livanos, George A.; Theotokatos, Gerasimos; Pagonis, Dimitrios-Nikolaos

2014-01-01

Highlights: • Alternative Diesel and Gas engine propulsion plants of Ferries and RoRos were studied. • Special focus on marine Natural Gas burning engines and ship waste heat recovery systems. • Significant savings in annual operating costs were predicted in the case of Natural Gas engines. • Environmental and economic optimum propulsion plant alternative was proposed in a specific case study. - Abstract: In this paper, the main alternative propulsion plants based on reciprocating internal combustion engines of a ferry or RoRo ship operating in routes that include Emission Control Areas (ECAs) are comparatively assessed. Specifically, a dual fuel engine propulsion plant is compared with a conventional Diesel engine plant. For both cases, the installation of a waste heat recovery system, which covers a part of the ship electric energy demand, is also considered. The ship main DF engines are assumed to operate using LNG and a small amount of MDO for initiating combustion, whereas low sulphur MDO was regarded as the fuel for the case of the Diesel engine plant. The installation of Selective Catalytic Reduction (SCR) after-treatment unit for reducing the NOx emissions for the case of Diesel engines plant is also taken into account. The propulsion plants were modelled under steady state conditions, and the simulation results were analysed in order to compare the alternative configurations. Furthermore, the Energy Efficiency Design Index (EEDI) values were calculated and the two examined propulsion system cases were compared on EEDI basis. Finally, the Life Cycle Cost for each alternative propulsion plant was calculated and used for completing an economic evaluation of the Dual fuel propulsion plant versus the conventional designs applied in ferries

Close-in characteristics of LH2/LOX reactions

Science.gov (United States)

Riehl, W. A.; Ullian, L. J.

1985-01-01

In deriving shock overpressures from space vehicles employing LH2 and LOX, separate methods of analyses and prediction are recommended, as a function of the distance. Three methods of treatment are recommended. For the Far Field - where the expected shock overpressure is less than 40 psi (lambda = 5) - use the classical PYRO approach to determine TNT yield, and employ classical ordnance (Kingery) curve to obtain the overall value. For the Close-In Range, a suggested limit is 3D, or a zone from a distance of three times the tank diameter to the tank wall. Rather than estimate a specific distance from the center of explosion to the target, it is only necessary to estimate whether this could be within one, two, or three diameters away from the wall; i.e., in the 1, 2, or 3D zone. Then assess whether mixing mode is by the PYRO CBGS (spill) mode or CBM (internal mixing) mode. From the zone and mixing mode, the probability of attaining various shock overpressures is determined from the plots provided herein. For the transition zone, between 40 psi and the 3D distance, it is tentatively recommended that both of the preceding methods be used, and to be conservative, the higher resulting value be used.

Full fuel-cycle comparison of forklift propulsion systems

International Nuclear Information System (INIS)

Gaines, L.L.; Elgowainy, A.; Wang, M.Q.

2008-01-01

Hydrogen has received considerable attention as an alternative to fossil fuels. The U.S. Department of Energy (DOE) investigates the technical and economic feasibility of promising new technologies, such as hydrogen fuel cells. A recent report for DOE identified three near-term markets for fuel cells: (1) Emergency power for state and local emergency response agencies, (2) Forklifts in warehousing and distribution centers, and (3) Airport ground support equipment markets. This report examines forklift propulsion systems and addresses the potential energy and environmental implications of substituting fuel-cell propulsion for existing technologies based on batteries and fossil fuels. Industry data and the Argonne Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation (GREET) model are used to estimate full fuel-cycle emissions and use of primary energy sources, back to the primary feedstocks for fuel production. Also considered are other environmental concerns at work locations. The benefits derived from using fuel-cell propulsion are determined by the sources of electricity and hydrogen. In particular, fuel-cell forklifts using hydrogen made from the reforming of natural gas had lower impacts than those using hydrogen from electrolysis

Full fuel-cycle comparison of forklift propulsion systems.

Energy Technology Data Exchange (ETDEWEB)

Gaines, L. L.; Elgowainy, A.; Wang, M. Q.; Energy Systems

2008-11-05

Hydrogen has received considerable attention as an alternative to fossil fuels. The U.S. Department of Energy (DOE) investigates the technical and economic feasibility of promising new technologies, such as hydrogen fuel cells. A recent report for DOE identified three near-term markets for fuel cells: (1) Emergency power for state and local emergency response agencies, (2) Forklifts in warehousing and distribution centers, and (3) Airport ground support equipment markets. This report examines forklift propulsion systems and addresses the potential energy and environmental implications of substituting fuel-cell propulsion for existing technologies based on batteries and fossil fuels. Industry data and the Argonne Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation (GREET) model are used to estimate full fuel-cycle emissions and use of primary energy sources, back to the primary feedstocks for fuel production. Also considered are other environmental concerns at work locations. The benefits derived from using fuel-cell propulsion are determined by the sources of electricity and hydrogen. In particular, fuel-cell forklifts using hydrogen made from the reforming of natural gas had lower impacts than those using hydrogen from electrolysis.

Lightweight Radiator for in Space Nuclear Electric Propulsion

Science.gov (United States)

Craven, Paul; Tomboulian, Briana; SanSoucie, Michael

2014-01-01

Nuclear electric propulsion (NEP) is a promising option for high-speed in-space travel due to the high energy density of nuclear fission power sources and efficient electric thrusters. Advanced power conversion technologies may require high operating temperatures and would benefit from lightweight radiator materials. Radiator performance dictates power output for nuclear electric propulsion systems. Game-changing propulsion systems are often enabled by novel designs using advanced materials. Pitch-based carbon fiber materials have the potential to offer significant improvements in operating temperature, thermal conductivity, and mass. These properties combine to allow advances in operational efficiency and high temperature feasibility. An effort at the NASA Marshall Space Flight Center to show that woven high thermal conductivity carbon fiber mats can be used to replace standard metal and composite radiator fins to dissipate waste heat from NEP systems is ongoing. The goals of this effort are to demonstrate a proof of concept, to show that a significant improvement of specific power (power/mass) can be achieved, and to develop a thermal model with predictive capabilities making use of constrained input parameter space. A description of this effort is presented.

Heavy Lift Launch Capability with a New Hydrocarbon Engine (NHE)

Science.gov (United States)

Threet, Grady E., Jr.; Holt, James B.; Philips, Alan D.; Garcia, Jessica A.

2011-01-01

The Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center has analyzed over 2000 Ares V and other heavy lift concepts in the last 3 years. These concepts were analyzed for Lunar Exploration Missions, heavy lift capability to Low Earth Orbit (LEO) as well as exploratory missions to other near earth objects in our solar system. With the pending retirement of the Shuttle fleet, our nation will be without a civil heavy lift launch capability, so the future development of a new heavy lift capability is imperative for the exploration and large science missions our Agency has been tasked to deliver. The majority of the heavy lift concepts analyzed by ACO during the last 3 years have been based on liquid oxygen / liquid hydrogen (LOX/LH2) core stage and solids booster stage propulsion technologies (Ares V / Shuttle Derived and their variants). These concepts were driven by the decisions made from the results of the Exploration Systems Architecture Study (ESAS), which in turn, led to the Ares V launch vehicle that has been baselined in the Constellation Program. Now that the decision has been made at the Agency level to cancel Constellation, other propulsion options such as liquid hydrocarbon fuels are back in the exploration trade space. NASA is still planning exploration missions with the eventual destination of Mars and a new heavy lift launch vehicle is still required and will serve as the centerpiece of our nation s next exploration architecture s infrastructure. With an extensive launch vehicle database already developed on LOX/LH2 based heavy lift launch vehicles, ACO initiated a study to look at using a new high thrust (> 1.0 Mlb vacuum thrust) hydrocarbon engine as the primary main stage propulsion in such a launch vehicle.

A cermet fuel reactor for nuclear thermal propulsion

International Nuclear Information System (INIS)

Kruger, G.

1991-01-01

Work on the cermet fuel reactor done in the 1960's by General Electric (GE) and the Argonne National Laboratory (ANL) that had as its goal the development of systems that could be used for nuclear rocket propulsion as well as closed cycle propulsion system designs for ship propulsion, space nuclear propulsion, and other propulsion systems is reviewed. It is concluded that we can have excellent thermal and mechanical performance with cermet fuel. Thousands of hours of testing were performed on the cermet fuel at both GE and AGL, including very rapid transients and some radiation performance history. We conclude that there are no feasibility issues with cermet fuel. What is needed is reactivation of existing technology and qualification testing of a specific fuel form. We believe this can be done with a minimum development risk

Overview and future prospects of laser plasma propulsion technology

International Nuclear Information System (INIS)

Zheng Zhiyuan; Lu Xin; Zhang Jie

2003-01-01

Due to its high cost, low efficiency, complex operation and unsatisfactory recycling, traditional rocket propulsion by chemical fuels has hindered the exploration of outer space to further limits. With the rapid development of laser and space technology, the new technology of laser propulsion exhibits unique advantages and prospects. The mechanism and current development of laser plasma propulsion are reviewed, with mention of the technical problems and focus issues of laser plasma in micro-flight propulsion

Fitting aerodynamics and propulsion into the puzzle

Science.gov (United States)

Johnston, Patrick J.; Whitehead, Allen H., Jr.; Chapman, Gary T.

1987-01-01

The development of an airbreathing single-stage-to-orbit vehicle, in particular the problems of aerodynamics and propulsion integration, is examined. The boundary layer transition on constant pressure surfaces at hypersonic velocities, and the effects of noise on the transition are investigated. The importance of viscosity, real-gas effects, and drag at hypersonic speeds is discussed. A propulsion system with sufficient propulsive lift to enhance the performance of the vehicle is being developed. The difficulties of engine-airframe integration are analyzed.

Advanced Chemical Propulsion System Study

Science.gov (United States)

Portz, Ron; Alexander, Leslie; Chapman, Jack; England, Chris; Henderson, Scott; Krismer, David; Lu, Frank; Wilson, Kim; Miller, Scott

2007-01-01

A detailed; mission-level systems study has been performed to show the benefit resulting from engine performance gains that will result from NASA's In-Space Propulsion ROSS Cycle 3A NRA, Advanced Chemical Technology sub-topic. The technology development roadmap to accomplish the NRA goals are also detailed in this paper. NASA-Marshall and NASA-JPL have conducted mission-level studies to define engine requirements, operating conditions, and interfaces. Five reference missions have been chosen for this analysis based on scientific interest, current launch vehicle capability and trends in space craft size: a) GTO to GEO, 4800 kg, delta-V for GEO insertion only approx.1830 m/s; b) Titan Orbiter with aerocapture, 6620 kg, total delta V approx.210 m/s, mostly for periapsis raise after aerocapture; c) Enceladus Orbiter (Titan aerocapture) 6620 kg, delta V approx.2400 m/s; d) Europa Orbiter, 2170 kg, total delta V approx.2600 m/s; and e) Mars Orbiter, 2250 kg, total delta V approx.1860 m/s. The figures of merit used to define the benefit of increased propulsion efficiency at the spacecraft level include propulsion subsystem wet mass, volume and overall cost. The objective of the NRA is to increase the specific impulse of pressure-fed earth storable bipropellant rocket engines to greater than 330 seconds with nitrogen tetroxide and monomothylhydrazine propellants and greater than 335 , seconds with nitrogen tetroxide and hydrazine. Achievement of the NRA goals will significantly benefit NASA interplanetary missions and other government and commercial opportunities by enabling reduced launch weight and/or increased payload. The study also constitutes a crucial stepping stone to future development, such as pump-fed storable engines.

Wheelchair propulsion kinematics in beginners and expert users: influence of wheelchair settings.

Science.gov (United States)

Gorce, P; Louis, N

2012-01-01

Biomechanical studies have linked the handrim wheelchair propulsion with a prevalence of upper limb musculoskeletal disorders. The purpose of this study was to examine the influence of the wheelchair settings on upper limb kinematics during wheelchair propulsion. Recordings were made under various wheelchair configuration conditions to understand the effect of wheelchair settings on kinematics parameters such shoulder, elbow and wrist angles. Ten experts and ten beginners' subjects propelled an experimental wheelchair on a roller ergometer system at a comfortable speed. Twelve wheelchair configurations were tested. Kinematics were recorded for each configuration. Based on the hand position relatively to the handrim, the main kinematic parameters of wheelchair propulsion were investigated on the whole propulsion cycle and a key event such as handrim contact and release. Compared to the beginner subjects, all the experts' subjects generally present higher joint amplitude and propulsion speeds. Seat height and antero-posterior axle position influence usage of the hand-rim, timing parameters and configurations of upper limb joints. Results seem to confirm that low and backward seat position allow a greater efficiency. Nevertheless, according that proximity of joint limit is a well known factor of musculoskeletal disorders, our results let us think that too low and backward seat position, increasing joints positions and amplitudes, could increase the risk of upper limb injuries in relation with manual wheelchair propulsion. Kinematic differences highlight that future studies on wheelchair propulsion should only be done with impaired experienced subjects. Furthermore, this study provides indications on how wheelchair settings can be used for upper limb injury prevention. Copyright © 2011 Elsevier Ltd. All rights reserved.

Thermo-hydraulic characteristics of ship propulsion reactor in the conditions of ship motions and safety assessment

International Nuclear Information System (INIS)

Kobayashi, Michiyuki; Aya, Izuo; Inasaka, Fujio; Murata, Hiroyuki; Odano, Naoteru; Shiozaki, Koki

1998-01-01

A research project from 1995-1999 had a plan to make experimental studies on (1) safety of nuclear ship loaded with an integral ship propulsion reactor (2) effects of pulsating flow on the thermo-hydraulic characteristics of ship propulsion reactor and (3) thermo-hydraulic behaviors of the reactor container at the time of accident in a passively safe ship propulsion reactor. Development of a data base for ship propulsion reactor was attempted using previous experimental data on the thermo-hydraulic characteristics of the reactor in the institute in addition to the present results aiming to make general analytical evaluation for the safety of the engineering-simulation system for nuclear ship. A general data base was obtained by integrating the data list and the analytical program for static characteristics. A test equipment which allows to visualize the pulsating flow was produced and visualization experiments have started. (M.N.)

Hybrid-electric propulsion for automotive and aviation applications

OpenAIRE

Friedrich, C; Robertson, Paul Andrew

2014-01-01

In parallel with the automotive industry, hybrid-electric propulsion is becoming a viable alternative propulsion technology for the aviation sector and reveals potential advantages including fuel savings, lower pollution, and reduced noise emission. Hybrid-electric propulsion systems can take advantage of the synergy between two technologies by utilizing both internal combustion engines and electric motors together, each operating at their respective optimum conditions...

Electric Motors for Vehicle Propulsion

OpenAIRE

Larsson, Martin

2014-01-01

This work is intended to contribute with knowledge to the area of electic motorsfor propulsion in the vehicle industry. This is done by first studying the differentelectric motors available, the motors suitable for vehicle propulsion are then dividedinto four different types to be studied separately. These four types are thedirect current, induction, permanent magnet and switched reluctance motors. Thedesign and construction are then studied to understand how the different typesdiffer from ea...

A Power-Efficient Propulsion Method for Magnetic Microrobots

Directory of Open Access Journals (Sweden)

Gioia Lucarini

2014-07-01

Full Text Available Current magnetic systems for microrobotic navigation consist of assemblies of electromagnets, which allow for the wireless accurate steering and propulsion of sub-millimetric bodies. However, large numbers of windings and/or high currents are needed in order to generate suitable magnetic fields and gradients. This means that magnetic navigation systems are typically cumbersome and require a lot of power, thus limiting their application fields. In this paper, we propose a novel propulsion method that is able to dramatically reduce the power demand of such systems. This propulsion method was conceived for navigation systems that achieve propulsion by pulling microrobots with magnetic gradients. We compare this power-efficient propulsion method with the traditional pulling propulsion, in the case of a microrobot swimming in a micro-structured confined liquid environment. Results show that both methods are equivalent in terms of accuracy and the velocity of the motion of the microrobots, while the new approach requires only one ninth of the power needed to generate the magnetic gradients. Substantial equivalence is demonstrated also in terms of the manoeuvrability of user-controlled microrobots along a complex path.

A conceptual study of the use of a particle bed reactor nuclear propulsion module for the orbital maneuvering vehicle

International Nuclear Information System (INIS)

Malloy, J.; Potekhen, D.

1989-01-01

This paper examines the use of a particle bed reactor nuclear engine for direct thrust in a spacecraft based on the NASA/TRW orbital maneuvering vehicle (OMV). It presents the conceptual design of a 500 lb thrust engine that matches critical design features of the existing OMV bi-propellant propulsion system. This application contrasts with the usual tendency to consider a nuclear heat source either for high thrust direct propulsion or as a power source for electric propulsion. A nuclear propulsion module adapted to the OMV could potentially accomplish several Department of Defense missions, such as multiple round trips from a space-based support platform at 280 NM to service a constellation of satellites orbiting at 1800 NM

A cermet fuel reactor for nuclear thermal propulsion

Science.gov (United States)

Kruger, Gordon

1991-01-01

Work on the cermet fuel reactor done in the 1960's by General Electric (GE) and the Argonne National Laboratory (ANL) that had as its goal the development of systems that could be used for nuclear rocket propulsion as well as closed cycle propulsion system designs for ship propulsion, space nuclear propulsion, and other propulsion systems is reviewed. It is concluded that the work done in the 1960's has demonstrated that we can have excellent thermal and mechanical performance with cermet fuel. Thousands of hours of testing were performed on the cermet fuel at both GE and AGL, including very rapid transients and some radiation performance history. We conclude that there are no feasibility issues with cermet fuel. What is needed is reactivation of existing technology and qualification testing of a specific fuel form. We believe this can be done with a minimum development risk.

S.S.T.O. performance assessment with in-flight lox collection

Science.gov (United States)

Vandenkerckhove, J.; Czysz, P.

1995-10-01

Much attention has recently been given, up to harware development to in-flight oxygen collection as a means to improve considerably the performance of both TSTO & SSTO vehicles. A first assessment suggests that it permits simultaneously to improve much both gross take-off weight (by more than 30%) & dry weight (by more than 15%) of an SSTO and to lower significantly the Mach number of transition scramjet → rocket, from 15 down below 10, thereby reducing dramatically the programmatic development risks. After having compared in-flight lox collection with other SSTO concepts, this paper provides a tentative assessment of the performance of SSTO vehicles taking advantage of it, in particular their sensitivity to changes in system characteristics such as transition Mach number, vehicle slenderness (i.e. Küchemann's parameter τ) or planform loading at take-off and in collection characteristics, in particular collection ratio & specific collection plant weight.

Airbreathing Propulsion An Introduction

CERN Document Server

Bose, Tarit

2012-01-01

Airbreathing Propulsion covers the physics of combustion, fluid and thermo-dynamics, and structural mechanics of airbreathing engines, including piston, turboprop, turbojet, turbofan, and ramjet engines. End-of-chapter exercises allow the reader to practice the fundamental concepts behind airbreathing propulsion, and the included PAGIC computer code will help the reader to examine the relationships between the performance parameters of different engines. Large amounts of data on many different piston, turbojet, and turboprop engines have been compiled for this book and are included as an appendix. This textbook is ideal for senior undergraduate and graduate students studying aeronautical engineering, aerospace engineering, and mechanical engineering.

Advanced Chemical Propulsion

Science.gov (United States)

Bai, S. Don

2000-01-01

Design, propellant selection, and launch assistance for advanced chemical propulsion system is discussed. Topics discussed include: rocket design, advance fuel and high energy density materials, launch assist, and criteria for fuel selection.

Pressure-Fed LOX/LCH4 Reaction Control System for Spacecraft: Transient Modeling and Thermal Vacuum Hotfire Test Results

Science.gov (United States)

Atwell, Matthew J.; Hurlbert, Eric A.; Melcher, J. C.; Morehead, Robert L.

2017-01-01

An integrated cryogenic liquid oxygen, liquid methane (LOX/LCH4) reaction control system (RCS) was tested at NASA Glenn Research Center's Plum Brook Station in the Spacecraft Propulsion Research Facility (B-2) under vacuum and thermal vacuum conditions. The RCS is a subsystem of the Integrated Cryogenic Propulsion Test Article (ICPTA), a pressure-fed LOX/LCH4 propulsion system composed of a single 2,800 lbf main engine, two 28 lbf RCS engines, and two 7 lbf RCS engines. Propellants are stored in four 48 inch diameter 5083 aluminum tanks that feed both the main engine and RCS engines in parallel. Helium stored cryogenically in a composite overwrapped pressure vessel (COPV) flows through a heat exchanger on the main engine before being used to pressurize the propellant tanks to a design operating pressure of 325 psi. The ICPTA is capable of simultaneous main engine and RCS operation. The RCS engines utilize a coil-on-plug (COP) ignition system designed for operation in a vacuum environment, eliminating corona discharge issues associated with a high voltage lead. There are two RCS pods on the ICPTA, with two engines on each pod. One of these two engines is a heritage flight engine from Project Morpheus. Its sea level nozzle was removed and replaced by an 85:1 nozzle machined using Inconel 718, resulting in a maximum thrust of 28 lbf under altitude conditions. The other engine is a scaled down version of the 28 lbf engine, designed to match the core and overall mixture ratios as well as other injector characteristics. This engine can produce a maximum thrust of 7 lbf with an 85:1 nozzle that was additively manufactured using Inconel 718. Both engines are film-cooled and capable of limited duration gas-gas and gas-liquid operation, as well as steady-state liquid-liquid operation. Each pod contains one of each version, such that two engines of the same thrust level can be fired as a couple on opposite pods. The RCS feed system is composed of symmetrical 3/8 inch lines

Real-time feedback enhances forward propulsion during walking in old adults.

Science.gov (United States)

Franz, Jason R; Maletis, Michela; Kram, Rodger

2014-01-01

Reduced propulsive function during the push-off phase of walking plays a central role in the deterioration of walking ability with age. We used real-time propulsive feedback to test the hypothesis that old adults have an underutilized propulsive reserve available during walking. 8 old adults (mean [SD], age: 72.1 [3.9] years) and 11 young adults (age: 21.0 [1.5] years) participated. For our primary aim, old subjects walked: 1) normally, 2) with visual feedback of their peak propulsive ground reaction forces, and 3) with visual feedback of their medial gastrocnemius electromyographic activity during push-off. We asked those subjects to match a target set to 20% and 40% greater propulsive force or push-off muscle activity than normal walking. We tested young subjects walking normally only to provide reference ground reaction force values. Walking normally, old adults exerted 12.5% smaller peak propulsive forces than young adults (Ppush-off muscle activities when we provided propulsive feedback. Most notably, force feedback elicited propulsive forces that were equal to or 10.5% greater than those of young adults (+20% target, P=0.87; +40% target, P=0.02). With electromyographic feedback, old adults significantly increased their push-off muscle activities but without increasing their propulsive forces. Old adults with propulsive deficits have a considerable and underutilized propulsive reserve available during level walking. Further, real-time propulsive feedback represents a promising therapeutic strategy to improve the forward propulsion of old adults and thus maintain their walking ability and independence. © 2013.

Propulsion Physics Using the Chameleon Density Model

Science.gov (United States)

Robertson, Glen A.

2011-01-01

To grow as a space faring race, future spaceflight systems will require a new theory of propulsion. Specifically one that does not require mass ejection without limiting the high thrust necessary to accelerate within or beyond our solar system and return within a normal work period or lifetime. The Chameleon Density Model (CDM) is one such model that could provide new paths in propulsion toward this end. The CDM is based on Chameleon Cosmology a dark matter theory; introduced by Khrouy and Weltman in 2004. Chameleon as it is hidden within known physics, where the Chameleon field represents a scalar field within and about an object; even in the vacuum. The CDM relates to density changes in the Chameleon field, where the density changes are related to matter accelerations within and about an object. These density changes in turn change how an object couples to its environment. Whereby, thrust is achieved by causing a differential in the environmental coupling about an object. As a demonstration to show that the CDM fits within known propulsion physics, this paper uses the model to estimate the thrust from a solid rocket motor. Under the CDM, a solid rocket constitutes a two body system, i.e., the changing density of the rocket and the changing density in the nozzle arising from the accelerated mass. Whereby, the interactions between these systems cause a differential coupling to the local gravity environment of the earth. It is shown that the resulting differential in coupling produces a calculated value for the thrust near equivalent to the conventional thrust model used in Sutton and Ross, Rocket Propulsion Elements. Even though imbedded in the equations are the Universe energy scale factor, the reduced Planck mass and the Planck length, which relates the large Universe scale to the subatomic scale.

Linear Transformer Drivers for Z-pinch Based Propulsion

Science.gov (United States)

Adams, Robert; Seidler, William; Giddens, Patrick; Fabisinski, Leo; Cassibry, Jason

2017-01-01

The MSFC/UAH team has been developing of a novel power management and distribution system called a Linear Transformer Driver (LTD). LTD's hold the promise of dramatically reducing the required mass to drive a z-pinch by replacing the capacitor banks which constitute half the mass of the entire system. The MSFC?UAH tea, is developing this technology in hope of integrating it with the Pulsed Fission Fusion (PuFF) propulsion concept. High-Voltage pulsed power systems used for Z-Pinch experimentation have in the past largely been based on Marx Generators. Marx generators deliver the voltage and current required for the Z-Pinch, but suffer from two significant drawbacks when applied to a flight system: they are very massive, consisting of high-voltage capacitor banks insulated in oil-filled tanks and they do not lend themselves to rapid pulsing. The overall goal of Phase 2 is to demonstrate the construction of a higher voltage stack from a number of cavities each of the design proven in Phase 1 and to characterize and understand the techniques for designing the stack. The overall goal of Phase 3 is to demonstrate the feasibility of constructing a higher energy cavity from a number of smaller LTD stacks, to characterize and understand the way in which the constituent stacks combine, and to extend this demonstration LTD to serve as the basis for a 64 kJ pulse generator for Z-Pinch experiments.

A logistics model for large space power systems

Science.gov (United States)

Koelle, H. H.

Space Power Systems (SPS) have to overcome two hurdles: (1) to find an attractive design, manufacturing and assembly concept and (2) to have available a space transportation system that can provide economical logistic support during the construction and operational phases. An initial system feasibility study, some five years ago, was based on a reference system that used terrestrial resources only and was based partially on electric propulsion systems. The conclusion was: it is feasible but not yet economically competitive with other options. This study is based on terrestrial and extraterrestrial resources and on chemical (LH 2/LOX) propulsion systems. These engines are available from the Space Shuttle production line and require small changes only. Other so-called advanced propulsion systems investigated did not prove economically superior if lunar LOX is available! We assume that a Shuttle derived Heavy Lift Launch Vehicle (HLLV) will become available around the turn of the century and that this will be used to establish a research base on the lunar surface. This lunar base has the potential to grow into a lunar factory producing LOX and construction materials for supporting among other projects also the construction of space power systems in geostationary orbit. A model was developed to simulate the logistics support of such an operation for a 50-year life cycle. After 50 years 111 SPS units with 5 GW each and an availability of 90% will produce 100 × 5 = 500 GW. The model comprises 60 equations and requires 29 assumptions of the parameter involved. 60-state variables calculated with the 60 equations mentioned above are given on an annual basis and as averages for the 50-year life cycle. Recycling of defective parts in geostationary orbit is one of the features of the model. The state-of-the-art with respect to SPS technology is introduced as a variable Mg mass/MW electric power delivered. If the space manufacturing facility, a maintenance and repair facility

Economic Experience in Creation and Operation of Commercial Propulsion Nuclear Plants. Annex VII

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-12-15

This annex considers the reduction of capital costs in commercial nuclear power by employing commercial scale production and common technologies of equipment design and fabrication, based on the vast production and operation experience of Russian Federation nuclear propulsion plants. The performed consideration proves the expediency of adopting the most effective engineering solutions and approaches used for production of propulsion nuclear plants in the production of commercial nuclear power plants.

Advances in Propulsive Bionic Feet and Their Actuation Principles

Directory of Open Access Journals (Sweden)

Pierre Cherelle

2014-07-01

Full Text Available In the past decades, researchers have deeply studied pathological and nonpathological gait to understand the human ankle function during walking. These efforts resulted in the development of new lower limb prosthetic devices aiming at raising the 3C-level (control, comfort, and cosmetics of amputees. Thanks to the technological advances in engineering and mechatronics, challenges in the field of prosthetics have become an important source of interest for roboticists. Currently, most of the bionic feet are still on a research level but show promising results and a preview of tomorrow's commercial prosthetic devices. In this paper, the authors present the current state-of-the-art and the latest advances in propulsive bionic feet with its actuation principles. The context of this review study is outlined followed by a brief description of the basics in human biomechanics and criteria for new prosthetic designs. A new categorization based on the actuation principle of propulsive ankle-foot prostheses is proposed. Based on simulations, the general principles and benefits of each actuation method are explained. The corresponding latest advances in propulsive bionic feet are presented together with their main characteristics and scientific outcomes. The authors also propose to the reader a comparison analysis of the presented devices with a discussion of the general tendencies in new prosthetic feet.

Analysis of Electric Propulsion System for Exploration of Saturn

Directory of Open Access Journals (Sweden)

Carlos Renato Huaura Solórzano

2009-01-01

Full Text Available Exploration of the outer planets has experienced new interest with the launch of the Cassini and the New Horizons Missions. At the present time, new technologies are under study for the better use of electric propulsion system in deep space missions. In the present paper, the method of the transporting trajectory is used to study this problem. This approximated method for the flight optimization with power-limited low thrust is based on the linearization of the motion of a spacecraft near a keplerian orbit that is close to the transfer trajectory. With the goal of maximizing the mass to be delivered in Saturn, several transfers were studied using nuclear, radioisotopic and solar electric propulsion systems.

In-Situ EBCs for High Performance Composite Propulsion Components, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Silicon Carbide based ceramic matrix composites (CMCs) offer the potential to fundamentally change the design and manufacture of aeronautical and space propulsion...

In-situ EBCs for High Performance Composite Propulsion Components, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Silicon Carbide based ceramic matrix composites (CMCs) offer the potential to fundamentally change the design and manufacture of aeronautical and space propulsion...

Magnetic levitation and MHD propulsion

International Nuclear Information System (INIS)

Tixador, P.

1994-01-01

Magnetic levitation and MHD propulsion are now attracting attention in several countries. Different superconducting MagLev and MHD systems will be described concentrating on, above all, the electromagnetic aspect. Some programmes occurring throughout the world will be described. Magnetic levitated trains could be the new high speed transportation system for the 21st century. Intensive studies involving MagLev trains using superconductivity have been carried our in Japan since 1970. The construction of a 43 km long track is to be the next step. In 1991 a six year programme was launched in the United States to evaluate the performances of MagLev systems for transportation. The MHD (MagnetoHydroDynamic) offers some interesting advantages (efficiency, stealth characteristics, ..) for naval propulsion and increasing attention is being paid towards it nowadays. Japan is also up at the top with the tests of Yamato I, a 260 ton MHD propulsed ship. (orig.)

Magnetic levitation and MHD propulsion

Energy Technology Data Exchange (ETDEWEB)

Tixador, P [CNRS/CRTBT-LEG, 38 - Grenoble (France)

1994-04-01

Magnetic levitation and MHD propulsion are now attracting attention in several countries. Different superconducting MagLev and MHD systems will be described concentrating on, above all, the electromagnetic aspect. Some programmes occurring throughout the world will be described. Magnetic levitated trains could be the new high speed transportation system for the 21st century. Intensive studies involving MagLev trains using superconductivity have been carried our in Japan since 1970. The construction of a 43 km long track is to be the next step. In 1991 a six year programme was launched in the United States to evaluate the performances of MagLev systems for transportation. The MHD (MagnetoHydroDynamic) offers some interesting advantages (efficiency, stealth characteristics, ..) for naval propulsion and increasing attention is being paid towards it nowadays. Japan is also up at the top with the tests of Yamato I, a 260 ton MHD propulsed ship. (orig.).

STATIC TESTS OF UNCONVENTIONAL PROPULSION UNITS FOR ULTRALIGHT AIRPLANES

Directory of Open Access Journals (Sweden)

Martin Helmich

2014-06-01

Full Text Available This paper presents static tests of a new unconventional propulsion unit for small aviation airplanes. Our laboratory stand – a fan drive demonstrator – enables us to compare various design options. We performed experiments to verify the propulsion functionality and a measurement procedure to determine the available thrust of the propulsion unit and its dependence on engine speed. The results used for subsequent optimization include the operating parameters of the propulsion unit, and the temperature and velocity fields in parts of the air duct.

An Overview of the CNES Propulsion Program for Spacecraft

Science.gov (United States)

Cadiou, A.; Darnon, F.; Gibek, I.; Jolivet, L.; Pillet, N.

2004-10-01

This paper presents an overview of the CNES spacecraft propulsion activities. The main existing and future projects corresponding to low earth orbit and geostationary platforms are described. These projects cover various types of propulsion subsystems: monopropellant, bipropellant and electric. Monopropellant is mainly used for low earth orbit applications such as earth observation (SPOT/Helios, PLEIADES) or scientific applications (minisatellite PROTEUS line and micro satellites MYRIADE line). Bipropellant is used for geostationary telecommunications satellites (@BUS). The field of application of electric propulsion is the station keeping of geostationary telecommunication satellites (@BUS), main propulsion for specific probes (SMART 1) and fine attitude control for dedicated micro satellites (MICROSCOPE). The preparation of the future and the associated Research and Technology program are also described in the paper. The future developments are mainly dedicated to the performance improvements of electric propulsion which leads to the development of thrusters with higher thrust and higher specific impulse than those existing today, the evaluation of the different low thrust technologies for formation flying applications, the development of new systems to pressurize the propellants (volatile liquid, micro pump), the research on green propellants and different actions concerning components such as over wrapped pressure vessels, valves, micro propulsion. A constant effort is also put on plume effect in chemical and electrical propulsion area (improvement of tools and test activities) in the continuity of the previous work. These different R &T activities are described in detail after a presentation of the different projects and of their propulsion subsystems. The scientific activity supporting the development of Hall thrusters is going on in the frame of the GDR (Groupement de Recherche) CNRS / Universities / CNES / SNECMA on Plasma Propulsion.

Wireless Networked Sensors for Remote Monitoring in Propulsion Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This NASA Phase I SBIR program would fabricate wireless networked nanomembrane (NM) based surface pressure sensors for remote monitoring in propulsion systems, using...

The influence of verbal training and visual feedback on manual wheelchair propulsion.

Science.gov (United States)

DeGroot, Keri K; Hollingsworth, Holly H; Morgan, Kerri A; Morris, Carrie L; Gray, David B

2009-03-01

To determine if verbal training with visual feedback improved manual wheelchair propulsion; to examine propulsion differences between an individual with paraplegia and an individual with tetraplegia. Quasi-experimental study: Nine manual wheelchair-using adults participated in propulsion assessments and training. Baseline propulsion performance was measured on several tasks on different surfaces. Participants were trained on a wheelchair treadmill with verbal and visual feedback to increase push length, reduce push frequency and to modify propulsion pattern. Handrim biomechanics were measured with an instrumented wheel. Changes in propulsion were assessed. Differences in propulsion characteristics between a participant with paraplegia and a participant with tetraplegia were examined. Push length increased (p propulsion characteristics between a participant with paraplegia and a participant with tetraplegia. Verbal training may produce changes in push biomechanics of manual wheelchair users. Longer training periods may be needed to sustain propulsion changes. Findings from this study support other studies that have shown propulsion differences between people with tetraplegia and paraplegia. Propulsion training for populations with upper-extremity impairments warrants further study.

Propulsion Electric Grid Simulator (PEGS) for Future Turboelectric Distributed Propulsion Aircraft

Science.gov (United States)

Choi, Benjamin B.; Morrison, Carlos; Dever, Timothy; Brown, Gerald V.

2014-01-01

NASA Glenn Research Center, in collaboration with the aerospace industry and academia, has begun the development of technology for a future hybrid-wing body electric airplane with a turboelectric distributed propulsion (TeDP) system. It is essential to design a subscale system to emulate the TeDP power grid, which would enable rapid analysis and demonstration of the proof-of-concept of the TeDP electrical system. This paper describes how small electrical machines with their controllers can emulate all the components in a TeDP power train. The whole system model in Matlab/Simulink was first developed and tested in simulation, and the simulation results showed that system dynamic characteristics could be implemented by using the closed-loop control of the electric motor drive systems. Then we designed a subscale experimental system to emulate the entire power system from the turbine engine to the propulsive fans. Firstly, we built a system to emulate a gas turbine engine driving a generator, consisting of two permanent magnet (PM) motors with brushless motor drives, coupled by a shaft. We programmed the first motor and its drive to mimic the speed-torque characteristic of the gas turbine engine, while the second motor and drive act as a generator and produce a torque load on the first motor. Secondly, we built another system of two PM motors and drives to emulate a motor driving a propulsive fan. We programmed the first motor and drive to emulate a wound-rotor synchronous motor. The propulsive fan was emulated by implementing fan maps and flight conditions into the fourth motor and drive, which produce a torque load on the driving motor. The stator of each PM motor is designed to travel axially to change the coupling between rotor and stator. This feature allows the PM motor to more closely emulate a wound-rotor synchronous machine. These techniques can convert the plain motor system into a unique TeDP power grid emulator that enables real-time simulation performance

PEGASUS: a multi-megawatt nuclear electric propulsion system

International Nuclear Information System (INIS)

Coomes, E.P.; Cuta, J.M.; Webb, B.J.; King, D.Q.

1985-06-01

With the Space Transportation System (STS), the advent of space station Columbus and the development of expertise at working in space that this will entail, the gateway is open to the final frontier. The exploration of this frontier is possible with state-of-the-art hydrogen/oxygen propulsion but would be greatly enhanced by the higher specific impulse of electric propulsion. This paper presents a concept that uses a multi-megawatt nuclear power plant to drive an electric propulsion system. The concept has been named PEGASUS, PowEr GenerAting System for Use in Space, and is intended as a ''work horse'' for general space transportation needs, both long- and short-haul missions. The recent efforts of the SP-100 program indicate that a power system capable of producing upwards of 1 megawatt of electric power should be available in the next decade. Additionally, efforts in other areas indicate that a power system with a constant power capability an order of magnitude greater could be available near the turn of the century. With the advances expected in megawatt-class space power systems, the high specific impulse propulsion systems must be reconsidered as potential propulsion systems. The power system is capable of meeting both the propulsion system and spacecraft power requirements

US Rocket Propulsion Industrial Base Health Metrics

Science.gov (United States)

Doreswamy, Rajiv

2013-01-01

The number of active liquid rocket engine and solid rocket motor development programs has severely declined since the "space race" of the 1950s and 1960s center dot This downward trend has been exacerbated by the retirement of the Space Shuttle, transition from the Constellation Program to the Space launch System (SLS) and similar activity in DoD programs center dot In addition with consolidation in the industry, the rocket propulsion industrial base is under stress. To Improve the "health" of the RPIB, we need to understand - The current condition of the RPIB - How this compares to past history - The trend of RPIB health center dot This drives the need for a concise set of "metrics" - Analogous to the basic data a physician uses to determine the state of health of his patients - Easy to measure and collect - The trend is often more useful than the actual data point - Can be used to focus on problem areas and develop preventative measures The nation's capability to conceive, design, develop, manufacture, test, and support missions using liquid rocket engines and solid rocket motors that are critical to its national security, economic health and growth, and future scientific needs. center dot The RPIB encompasses US government, academic, and commercial (including industry primes and their supplier base) research, development, test, evaluation, and manufacturing capabilities and facilities. center dot The RPIB includes the skilled workforce, related intellectual property, engineering and support services, and supply chain operations and management. This definition touches the five main segments of the U.S. RPIB as categorized by the USG: defense, intelligence community, civil government, academia, and commercial sector. The nation's capability to conceive, design, develop, manufacture, test, and support missions using liquid rocket engines and solid rocket motors that are critical to its national security, economic health and growth, and future scientific needs

Non-Toxic Orbital Maneuvering System Engine Development

Science.gov (United States)

Green, Christopher; Claflin, Scott; Maeding, Chris; Butas, John

1999-01-01

Recent results using the Aestus engine operated with LOx/ethanol propellant are presented. An experimental program at Rocketdyne Propulsion and Power is underway to adapt this engine for the Boeing Reusable Space Systems Division non-toxic Orbital Maneuvering System/Reaction control System (OMS/RCS) system. Daimler-Chrysler Aerospace designed the Aestus as an nitrogen tetroxide/monomethyl hydrazine (NTO/MMH) upper-stage engine for the Ariane 5. The non-toxic OMS/RCS system's preliminary design requires a LOx/ethanol (O2/C2H5OH) engine that operates with a mixture ratio of 1.8, a specific impulse of 323 seconds, and fits within the original OMS design envelope. This paper describes current efforts to meet these requirements including, investigating engine performance using LOx/ethanol, developing the en-ine system sizing package, and meeting the vehicle operation parameters. Data from hot-fire testing are also presented and discussed.

Radioisotope electric propulsion of sciencecraft to the outer solar system and near-interstellar space

International Nuclear Information System (INIS)

Noble, R.J.

1998-08-01

Recent results are presented in the study of radioisotope electric propulsion as a near-term technology for sending small robotic sciencecraft to the outer Solar System and near-interstellar space. Radioisotope electric propulsion (REP) systems are low-thrust, ion propulsion units based on radioisotope electric generators and ion thrusters. Powerplant specific masses are expected to be in the range of 100 to 200 kg/kW of thrust power. Planetary rendezvous missions to Pluto, fast missions to the heliopause (100 AU) with the capability to decelerate an orbiter for an extended science program and prestellar missions to the first gravitational lens focus of the Sun (550 AU) are investigated

Propulsion Wheel Motor for an Electric Vehicle

Science.gov (United States)

Figuered, Joshua M. (Inventor); Herrera, Eduardo (Inventor); Waligora, Thomas M. (Inventor); Bluethmann, William J. (Inventor); Farrell, Logan Christopher (Inventor); Lee, Chunhao J. (Inventor); Vitale, Robert L. (Inventor); Winn, Ross Briant (Inventor); Eggleston, IV, Raymond Edward (Inventor); Guo, Raymond (Inventor);

Study of underwater laser propulsion using different target materials.

Science.gov (United States)

Qiang, Hao; Chen, Jun; Han, Bing; Shen, Zhong-Hua; Lu, Jian; Ni, Xiao-Wu

2014-07-14

In order to investigate the influence of target materials, including aluminum (Al), titanium (Ti) and copper (Cu), on underwater laser propulsion, the analytical formula of the target momentum IT is deduced from the enhanced coupling theory of laser propulsion in atmosphere with transparent overlay metal target. The high-speed photography method and numerical simulation are employed to verify the IT model. It is shown that the enhanced coupling theory, which was developed originally for laser propulsion in atmosphere, is also applicable to underwater laser propulsion with metal targets.

An Overview of the NASA FAP Hypersonics Project Airbreathing Propulsion Research

Science.gov (United States)

Auslender, A. H.; Suder, Kenneth L.; Thomas, Scott R.

2009-01-01

The propulsion research portfolio of the National Aeronautics and Space Administration Fundamental Aeronautics Program Hypersonics Project encompasses a significant number of technical tasks that are aligned to achieve mastery and intellectual stewardship of the core competencies in the hypersonic-flight regime. An overall coordinated programmatic and technical effort has been structured to advance the state-of-the-art, via both experimental and analytical efforts. A subset of the entire hypersonics propulsion research portfolio is presented in this overview paper. To this end, two programmatic research disciplines are discussed; namely, (1) the Propulsion Discipline, including three associated research elements: the X-51A partnership, the HIFiRE-2 partnership, and the Durable Combustor Rig, and (2) the Turbine-Based Combine Cycle Discipline, including three associated research elements: the Combined Cycle Engine Large Scale Inlet Mode Transition Experiment, the small-scale Inlet Mode Transition Experiment, and the High-Mach Fan Rig.

Mars Sample Return Using Solar Sail Propulsion

Science.gov (United States)

Johnson, Les; Macdonald, Malcolm; Mcinnes, Colin; Percy, Tom

2012-01-01

Many Mars Sample Return (MSR) architecture studies have been conducted over the years. A key element of them is the Earth Return Stage (ERS) whose objective is to obtain the sample from the Mars Ascent Vehicle (MAV) and return it safely to the surface of the Earth. ERS designs predominantly use chemical propulsion [1], incurring a significant launch mass penalty due to the low specific impulse of such systems coupled with the launch mass sensitivity to returned mass. It is proposed to use solar sail propulsion for the ERS, providing a high (effective) specific impulse propulsion system in the final stage of the multi-stage system. By doing so to the launch mass of the orbiter mission can be significantly reduced and hence potentially decreasing mission cost. Further, solar sailing offers a unique set of non-Keplerian low thrust trajectories that may enable modifications to the current approach to designing the Earth Entry Vehicle by potentially reducing the Earth arrival velocity. This modification will further decrease the mass of the orbiter system. Solar sail propulsion uses sunlight to propel vehicles through space by reflecting solar photons from a large, mirror-like surface made of a lightweight, reflective material. The continuous photonic pressure provides propellantless thrust to conduct orbital maneuvering and plane changes more efficiently than conventional chemical propulsion. Because the Sun supplies the necessary propulsive energy, solar sails require no onboard propellant, thus reducing system mass. This technology is currently at TRL 7/8 as demonstrated by the 2010 flight of the Japanese Aerospace Exploration Agency, JAXA, IKAROS mission. [2

DISCRETION MAGNETIQUE DES MACHINES ELECTRIQUES DE PROPULSION NAVALE

OpenAIRE

Froidurot , Benoît

2002-01-01

For about ten years, electrical machines have been commonly used in naval propulsion systems for civilian applications. This is mainly due to new magnetic materials (magnets...) and power drive electronic, which increase the performances of the machines. This kind of propulsion is planed to be implemented on military ships. However, some constraints of discretion make this propulsion require specific systems for the ship security. This study is then dedicted to the magnetic discretion of nava...

Children's Gender-Typed Toy Interests: Does Propulsion Matter?

Science.gov (United States)

Dinella, Lisa M; Weisgram, Erica S; Fulcher, Megan

2017-07-01

Children's toy play is at the foundation of child development. However, gender differentiation in early play experiences may result in gender differences in cognitive abilities, social interactions, and vocational choices. We investigated gender-typing of toys and toys' propulsive properties (e.g., wheels, forward motion) as possible factors impacting children's toy interests, perceptions of other children's interests, and children's actual toy choices during free play. In Studies 1 and 2, 82 preschool children (42 boys, 40 girls; mean age = 4.90 years) were asked to report their interest and perceptions of other children's interests in toys. In Study 1, masculine, feminine, and neutral toys with and without propulsive properties were presented. Children reported greater interest in gender-typed toys and neutral toys compared to cross-gender-typed toys. In Study 2, unfamiliar, neutral toys with and without propulsive properties were presented. Propulsive properties did not affect children's interest across both studies. Study 3 was an observational study that assessed toy preferences among 42 preschool children (21 males, 21 females, mean age = 4.49 years) during a play session with masculine, feminine, and neutral toys with and without propulsive properties. Gender-typed toy preferences were less apparent than expected, with children showing high interest in neutral toys, and girls playing with a wide variety of masculine, feminine, and neutral toys. Gender differences in interest for toys with propulsion properties were not evident. Overall, gender differences in children's interest in toys as a function of propulsion properties were not found in the three experiments within this study.

The Enabling Use of Ion Propulsion on Dawn

Science.gov (United States)

Rayman, M.; Russell, C. T.; Raymond, C. A.; Mase, R. M.

2011-12-01

Dawn's mission to orbit both Vesta and Ceres is enabled by its use of ion propulsion. Even orbiting Vesta alone with conventional propulsion would have been unaffordable within the constraints of the Discovery Program, and orbiting both would have been impossible. In fact, no other spacecraft has been targeted to orbit two solar system destinations, which is only one of the many firsts that Dawn will achieve. The successful testing of ion propulsion on Deep Space 1 paved the way for Dawn not only to use the hardware with confidence but also to learn how to design the flight system and design the mission to take advantage of its capabilities. In addition to allowing Dawn to reach these two important targets, ion propulsion allows the spacecraft to accomplish significant changes in its orbit. Therefore, science observations of Vesta are planned from four different orbits, at varying altitudes and solar geometry. The use of ion propulsion results in a significant mission design effort since the trajectory is constantly being refined. This also creates a flexible mission architecture, which allows for optimization of the mission as conditions change. Solar electric ion propulsion is especially well suited to missions to the Main Asteroid Belt since solar energy is still a viable power source, whereas the size of the solar array needed beyond 3.5 AU is a potential limitation. Dawn has already surpassed the record for greatest propulsive velocity, but its greatest achievements will no doubt be the incredible bounty of science data enabled by this innovative flight system.

Status of Turbulence Modeling for Hypersonic Propulsion Flowpaths

Science.gov (United States)

Georgiadis, Nicholas J.; Yoder, Dennis A.; Vyas, Manan A.; Engblom, William A.

2012-01-01

This report provides an assessment of current turbulent flow calculation methods for hypersonic propulsion flowpaths, particularly the scramjet engine. Emphasis is placed on Reynolds-averaged Navier-Stokes (RANS) methods, but some discussion of newer meth- ods such as Large Eddy Simulation (LES) is also provided. The report is organized by considering technical issues throughout the scramjet-powered vehicle flowpath including laminar-to-turbulent boundary layer transition, shock wave / turbulent boundary layer interactions, scalar transport modeling (specifically the significance of turbulent Prandtl and Schmidt numbers) and compressible mixing. Unit problems are primarily used to conduct the assessment. In the combustor, results from calculations of a direct connect supersonic combustion experiment are also used to address the effects of turbulence model selection and in particular settings for the turbulent Prandtl and Schmidt numbers. It is concluded that RANS turbulence modeling shortfalls are still a major limitation to the accuracy of hypersonic propulsion simulations, whether considering individual components or an overall system. Newer methods such as LES-based techniques may be promising, but are not yet at a maturity to be used routinely by the hypersonic propulsion community. The need for fundamental experiments to provide data for turbulence model development and validation is discussed.

Space station propulsion requirements study

Science.gov (United States)

Wilkinson, C. L.; Brennan, S. M.

1985-01-01

Propulsion system requirements to support Low Earth Orbit (LEO) manned space station development and evolution over a wide range of potential capabilities and for a variety of STS servicing and space station operating strategies are described. The term space station and the overall space station configuration refers, for the purpose of this report, to a group of potential LEO spacecraft that support the overall space station mission. The group consisted of the central space station at 28.5 deg or 90 deg inclinations, unmanned free-flying spacecraft that are both tethered and untethered, a short-range servicing vehicle, and a longer range servicing vehicle capable of GEO payload transfer. The time phasing for preferred propulsion technology approaches is also investigated, as well as the high-leverage, state-of-the-art advancements needed, and the qualitative and quantitative benefits of these advancements on STS/space station operations. The time frame of propulsion technologies applicable to this study is the early 1990's to approximately the year 2000.

NASA program planning on nuclear electric propulsion

International Nuclear Information System (INIS)

Bennett, G.L.; Miller, T.J.

1992-03-01

As part of the focused technology planning for future NASA space science and exploration missions, NASA has initiated a focused technology program to develop the technologies for nuclear electric propulsion and nuclear thermal propulsion. Beginning in 1990, NASA began a series of interagency planning workshops and meetings to identify key technologies and program priorities for nuclear propulsion. The high-priority, near-term technologies that must be developed to make NEP operational for space exploration include scaling thrusters to higher power, developing high-temperature power processing units, and developing high power, low-mass, long-lived nuclear reactors. 28 refs

Nuclear thermal propulsion engine cost trade studies

International Nuclear Information System (INIS)

Paschall, R.K.

1993-01-01

The NASA transportation strategy for the Mars Exploration architecture includes the use of nuclear thermal propulsion as the primary propulsion system for Mars transits. It is anticipated that the outgrowth of the NERVA/ROVER programs will be a nuclear thermal propulsion (NTP) system capable of providing the propulsion for missions to Mars. The specific impulse (Isp) for such a system is expected to be in the 870 s range. Trade studies were conducted to investigate whether or not it may be cost effective to invest in a higher performance (Isp>870 s) engine for nuclear thermal propulsion for missions to Mars. The basic cost trades revolved around the amount of mass that must be transported to low-earth orbit prior to each Mars flight and the cost to launch that mass. The mass required depended on the assumptions made for Mars missions scenarios including piloted/cargo flights, number of Mars missions, and transit time to Mars. Cost parameters included launch cost, program schedule for development and operations, and net discount rate. The results were very dependent on the assumptions that were made. Under some assumptions, higher performance engines showed cost savings in the billions of dollars; under other assumptions, the additional cost to develop higher performance engines was not justified

Status and Mission Applicability of NASA's In-Space Propulsion Technology Project

Science.gov (United States)

Anderson, David J.; Munk, Michelle M.; Dankanich, John; Pencil, Eric; Liou, Larry

2009-01-01

The In-Space Propulsion Technology (ISPT) project develops propulsion technologies that will enable or enhance NASA robotic science missions. Since 2001, the ISPT project developed and delivered products to assist technology infusion and quantify mission applicability and benefits through mission analysis and tools. These in-space propulsion technologies are applicable, and potentially enabling for flagship destinations currently under evaluation, as well as having broad applicability to future Discovery and New Frontiers mission solicitations. This paper provides status of the technology development, near-term mission benefits, applicability, and availability of in-space propulsion technologies in the areas of advanced chemical thrusters, electric propulsion, aerocapture, and systems analysis tools. The current chemical propulsion investment is on the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance for lower cost. Investments in electric propulsion technologies focused on completing NASA's Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system, and the High Voltage Hall Accelerator (HiVHAC) thruster, which is a mid-term product specifically designed for a low-cost electric propulsion option. Aerocapture investments developed a family of thermal protections system materials and structures; guidance, navigation, and control models of blunt-body rigid aeroshells; atmospheric models for Earth, Titan, Mars and Venus; and models for aerothermal effects. In 2009 ISPT started the development of propulsion technologies that would enable future sample return missions. The paper describes the ISPT project's future focus on propulsion for sample return missions. The future technology development areas for ISPT is: Planetary Ascent Vehicles (PAV), with a Mars Ascent Vehicle (MAV) being the initial development focus; multi-mission technologies for Earth Entry Vehicles (MMEEV) needed

Promoting Physical Activity Through a Manual Wheelchair Propulsion Intervention in Persons With Multiple Sclerosis.

Science.gov (United States)

Rice, Ian M; Rice, Laura A; Motl, Robert W

2015-10-01

To examine the efficacy and feasibility of a multifactorial intervention to increase lifestyle physical activity in nonambulatory persons with multiple sclerosis (MS) based on wheelchair optimization, propulsion skill/technique training, and behavioral strategies based on social cognitive theory. Randomized controlled trial, 3-month postintervention follow-up. Home and general community, and university research laboratory. Nonambulatory individuals with MS (N=14; mean age ± SD, 53.6±8.7y) were randomly assigned to an intervention group (IG) or a control group (CG). After baseline testing, the IG participants received custom-fit, ultralightweight manual wheelchairs with propulsion/skills training, followed by 3 months of at-home use with the custom ultralightweight wheelchair and weekly phone calls to deliver support through a multifactorial intervention. The CG participants received no training and used their own wheelchairs at home during this time. All subjects were assessed at baseline and 3 months later for fatigue (Fatigue Severity Scale), upper extremity strength (digital handheld dynamometer), and propulsion technique (on a treadmill [0.5m/s] with instrumented wheels). Two 1-week bouts of physical activity were measured in both groups from home with wrist-worn accelerometry at the beginning (IG and CG in own wheelchairs) and end (IG in study wheelchair, CG in own) of the 3-month period of home use. The intervention was well tolerated, and no adverse events were reported. The IG demonstrated increased strength (P=.008) and a trend toward less fatigue (P=.068), both with large effect sizes (d>0.8), as well as reduced application of braking torque during propulsion (P=.003) with a moderate/large effect size (d=.73), compared with the CG. Findings suggest a 3-month physical activity intervention based on manual wheelchair propulsion and training is safe and feasible for some wheelchair users living with MS and may produce secondary benefits in strength

Laser Propulsion - Is it another myth or a real potential?

International Nuclear Information System (INIS)

Cook, Joung R.

2008-01-01

This paper discusses different principles of inducing propulsive power using lasers and examines the performance limits along with pros and cons with respect to different space propulsion applications: satellite launching, orbital transfer, space debris clearing, satellite propulsion, and space travels. It concludes that a use of electrical propulsion, in conjunction with laser power beaming, is the most feasible application with technological and economic advantages for commercial use within the next decades

FY2015 Propulsion Materials Annual Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-12-30

The Propulsion Materials Program actively supports the energy security and reduction of greenhouse emissions goals of VTO by investigating and identifying the materials properties that are most essential for continued development of cost-effective, highly efficient, and environmentally friendly next-generation heavy and light-duty powertrains. The technical approaches available to enhance propulsion systems focus on improvements in both vehicle efficiency and fuel substitution, both of which must overcome the performance limitations of the materials currently in use. Propulsion Materials Program activities work with national laboratories, industry experts, and VTO powertrain systems (e.g., Advanced Combustion Engines [ACE], Advanced Power Electronics and Electrical Machines [APEEM], and fuels) teams to develop strategies that overcome materials limitations in future powertrain performance. The technical maturity of the portfolio of funded projects ranges from basic science to subsystem prototype validation. Projects within a Propulsion Materials Program activity address materials concerns that directly impact critical technology barriers within each of the above programs, including barriers that impact fuel efficiency, thermal management, emissions reduction, improved reliability, and reduced manufacturing costs. The program engages only the barriers that result from material property limitations and represent fundamental, high-risk materials issues.

Measurement Issues In Pulsed Laser Propulsion

International Nuclear Information System (INIS)

Sinko, John E.; Scharring, Stefan; Eckel, Hans-Albert; Roeser, Hans-Peter; Sasoh, Akihiro

2010-01-01

Various measurement techniques have been used throughout the over 40-year history of laser propulsion. Often, these approaches suffered from inconsistencies in definitions of the key parameters that define the physics of laser ablation impulse generation. Such parameters include, but are not limited to the pulse energy, spot area, imparted impulse, and ablated mass. The limits and characteristics of common measurement techniques in each of these areas will be explored as they relate to laser propulsion. The idea of establishing some standardization system for laser propulsion data is introduced in this paper, so that reported results may be considered and studied by the general community with more certain understanding of particular merits and limitations. In particular, it is the intention to propose a minimum set of requirements a literature study should meet. Some international standards for measurements are already published, but modifications or revisions of such standards may be necessary for application to laser ablation propulsion. Issues relating to development of standards will be discussed, as well as some examples of specific experimental circumstances in which standardization would have prevented misinterpretation or misuse of past data.

Advanced supersonic propulsion study. [with emphasis on noise level reduction

Science.gov (United States)

Sabatella, J. A. (Editor)

1974-01-01

A study was conducted to determine the promising propulsion systems for advanced supersonic transport application, and to identify the critical propulsion technology requirements. It is shown that noise constraints have a major effect on the selection of the various engine types and cycle parameters. Several promising advanced propulsion systems were identified which show the potential of achieving lower levels of sideline jet noise than the first generation supersonic transport systems. The non-afterburning turbojet engine, utilizing a very high level of jet suppression, shows the potential to achieve FAR 36 noise level. The duct-heating turbofan with a low level of jet suppression is the most attractive engine for noise levels from FAR 36 to FAR 36 minus 5 EPNdb, and some series/parallel variable cycle engines show the potential of achieving noise levels down to FAR 36 minus 10 EPNdb with moderate additional penalty. The study also shows that an advanced supersonic commercial transport would benefit appreciably from advanced propulsion technology. The critical propulsion technology needed for a viable supersonic propulsion system, and the required specific propulsion technology programs are outlined.

Distributed Multi-propulsion Units System

OpenAIRE

原田, 正志; HARADA, Masashi

2002-01-01

Reduction of the weight of the propulsion system is important in the design of a stratospheric airship. However, it also important to increaseefficiency of the system because available energy generated by solar cells on the hull is quite limited. One solution to increase efficiency of the propulsion system is to use a stern propeller, the propeller mounted on the stern of the hull as shown in Figure 1. Mounted on the stern of the hull, the stern propeller is merged with the boundary layer of ...

Propulsion and Power Technologies for the NASA Exploration Vision: A Research Perspective

Science.gov (United States)

Litchford, Ron J.

2004-01-01

Future propulsion and power technologies for deep space missions are profiled in this viewgraph presentation. The presentation includes diagrams illustrating possible future travel times to other planets in the solar system. The propulsion technologies researched at Marshall Space Flight Center (MSFC) include: 1) Chemical Propulsion; 2) Nuclear Propulsion; 3) Electric and Plasma Propulsion; 4) Energetics. The presentation contains additional information about these technologies, as well as space reactors, reactor simulation, and the Propulsion Research Laboratory (PRL) at MSFC.

Hybrid Electric Propulsion Technologies for Commercial Transports

Science.gov (United States)

Bowman, Cheryl; Jansen, Ralph; Jankovsky, Amy

2016-01-01

NASA Aeronautics Research Mission Directorate has set strategic research thrusts to address the major drivers of aviation such as growth in demand for high-speed mobility, addressing global climate and capitalizing in the convergence of technological advances. Transitioning aviation to low carbon propulsion is one of the key strategic research thrust and drives the search for alternative and greener propulsion system for advanced aircraft configurations. This work requires multidisciplinary skills coming from multiple entities. The Hybrid Gas-Electric Subproject in the Advanced Air Transportation Project is energizing the transport class landscape by accepting the technical challenge of identifying and validating a transport class aircraft with net benefit from hybrid propulsion. This highly integrated aircraft of the future will only happen if airframe expertise from NASA Langley, modeling and simulation expertise from NASA Ames, propulsion expertise from NASA Glenn, and the flight research capabilities from NASA Armstrong are brought together to leverage the rich capabilities of U.S. Industry and Academia.

A Modeling Framework to Investigate the Radial Component of the Pushrim Force in Manual Wheelchair Propulsion

Directory of Open Access Journals (Sweden)

Ackermann Marko

2015-01-01

Full Text Available The ratio of tangential to total pushrim force, the so-called Fraction Effective Force (FEF, has been used to evaluate wheelchair propulsion efficiency based on the fact that only the tangential component of the force on the pushrim contributes to actual wheelchair propulsion. Experimental studies, however, consistently show low FEF values and recent experimental as well as modelling investigations have conclusively shown that a more tangential pushrim force direction can lead to a decrease and not increase in propulsion efficiency. This study aims at quantifying the contributions of active, inertial and gravitational forces to the normal pushrim component. In order to achieve this goal, an inverse dynamics-based framework is proposed to estimate individual contributions to the pushrim forces using a model of the wheelchair-user system. The results show that the radial pushrim force component arise to a great extent due to purely mechanical effects, including inertial and gravitational forces. These results corroborate previous findings according to which radial pushrim force components are not necessarily a result of inefficient propulsion strategies or hand-rim friction requirements. This study proposes a novel framework to quantify the individual contributions of active, inertial and gravitational forces to pushrim forces during wheelchair propulsion.

Interplanetary space transport using inertial fusion propulsion

International Nuclear Information System (INIS)

Orth, C.D.

1998-01-01

In this paper, we indicate how the great advantages that ICF offers for interplanetary propulsion can be accomplished with the VISTA spacecraft concept. The performance of VISTA is expected to surpass that from other realistic technologies for Mars missions if the energy gain achievable for ICF targets is above several hundred. Based on the good performance expected from the U. S. National Ignition Facility (NIF), the requirements for VISTA should be well within the realm of possibility if creative target concepts such as the fast ignitor can be developed. We also indicate that a 6000-ton VISTA can visit any planet in the solar system and return to Earth in about 7 years or less without any significant physiological hazards to astronauts. In concept, VISTA provides such short-duration missions, especially to Mars, that the hazards from cosmic radiation and zero gravity can be reduced to insignificant levels. VISTA therefore represents a significant step forward for space-propulsion concepts

Optimization analysis of propulsion motor control efficiency

Directory of Open Access Journals (Sweden)

CAI Qingnan

2017-12-01

Full Text Available [Objectives] This paper aims to strengthen the control effect of propulsion motors and decrease the energy used during actual control procedures.[Methods] Based on the traditional propulsion motor equivalence circuit, we increase the iron loss current component, introduce the definition of power matching ratio, calculate the highest efficiency of a motor at a given speed and discuss the flux corresponding to the power matching ratio with the highest efficiency. In the original motor vector efficiency optimization control module, an efficiency optimization control module is added so as to achieve motor efficiency optimization and energy conservation.[Results] MATLAB/Simulink simulation data shows that the efficiency optimization control method is suitable for most conditions. The operation efficiency of the improved motor model is significantly higher than that of the original motor model, and its dynamic performance is good.[Conclusions] Our motor efficiency optimization control method can be applied in engineering to achieve energy conservation.

Nuclear propulsion tradeoffs for manned Mars missions

International Nuclear Information System (INIS)

Walton, L.A.; Malloy, J.D.

1991-01-01

A conjunction class split/sprint manned Mars exploration mission was studied to evaluate tradeoffs in performance characteristics of nuclear thermal rockets. A Particle Bed Reactor-based nuclear thermal rocket was found to offer a 38% to 52% total mass savings compared with a NERVA-based nuclear thermal rocket for this mission. This advantage is primarily due to the higher thrust-to-weight ratio of the Particle Bed Reactor nuclear rocket. The mission is enabled by nuclear thermal rockets. It cannot be performed practically using chemical propulsion

Legal Implications of Nuclear Propulsion for Space Objects

Science.gov (United States)

Pop, V.

2002-01-01

This paper is intended to examine nuclear propulsion concepts such as "Project Orion", "Project Daedalus", NERVA, VASIMIR, from the legal point of view. The UN Principles Relevant to the Use of Nuclear Power Sources in Outer Space apply to nuclear power sources in outer space devoted to the generation of electric power on board space objects for non-propulsive purposes, and do not regulate the use of nuclear energy as a means of propulsion. However, nuclear propulsion by means of detonating atomic bombs (ORION) is, in principle, banned under the 1963 Treaty Banning Nuclear Weapon Tests in the Atmosphere, in Outer Space, and Under Water. The legality of use of nuclear propulsion will be analysed from different approaches - historical (i.e. the lawfulness of these projects at the time of their proposal, at the present time, and in the future - in the light of the mutability and evolution of international law), spatial (i.e. the legal regime governing peaceful nuclear explosions in different spatial zones - Earth atmosphere, Earth orbit, Solar System, and interstellar space), and technical (i.e, the legal regime applicable to different nuclear propulsion techniques, and to the various negative effects - e.g. damage to other space systems as an effect of the electromagnetic pulse, etc). The paper will analyse the positive law, and will also come with suggestions "de lege ferenda".

Magnetic levitation and MHD propulsion

Science.gov (United States)

Tixador, P.

1994-04-01

Magnetic levitation and MHD propulsion are now attracting attention in several countries. Different superconducting MagLev and MHD systems will be described concentrating on, above all, the electromagnetic aspect. Some programmes occurring throughout the world will be described. Magnetic levitated trains could be the new high speed transportation system for the 21st century. Intensive studies involving MagLev trains using superconductivity have been carried out in Japan since 1970. The construction of a 43 km long track is to be the next step. In 1991 a six year programme was launched in the United States to evaluate the performances of MagLev systems for transportation. The MHD (MagnetoHydroDynamic) offers some interesting advantages (efficiency, stealth characteristics, ...) for naval propulsion and increasing attention is being paid towards it nowadays. Japan is also up at the top with the tests of Yamato I, a 260 ton MHD propulsed ship. Depuis quelques années nous assistons à un redémarrage de programmes concernant la lévitation et la propulsion supraconductrices. Différents systèmes supraconducteurs de lévitation et de propulsion seront décrits en examinant plus particulièrement l'aspect électromagnétique. Quelques programmes à travers le monde seront abordés. Les trains à sustentation magnétique pourraient constituer un nouveau mode de transport terrestre à vitesse élevée (500 km/h) pour le 21^e siècle. Les japonais n'ont cessé de s'intéresser à ce système avec bobine supraconductrice. Ils envisagent un stade préindustriel avec la construction d'une ligne de 43 km. En 1991 un programme américain pour une durée de six ans a été lancé pour évaluer les performances des systèmes à lévitation pour le transport aux Etats Unis. La MHD (Magnéto- Hydro-Dynamique) présente des avantages intéressants pour la propulsion navale et un regain d'intérêt apparaît à l'heure actuelle. Le japon se situe là encore à la pointe des d

Dynamic simulator for PEFC propulsion plant

Energy Technology Data Exchange (ETDEWEB)

Hiraide, Masataka; Kaneda, Eiichi; Sato, Takao [Mitsui Engineering & Shipbuilding Co., Ltd., Tokyo (Japan)] [and others

1996-12-31

This report covers part of a joint study on a PEFC propulsion system for surface ships, summarized in a presentation to this Seminar, entitled {open_quote}Study on a Polymer Electrolyte Fuel Cell (PEFC) Propulsion System for Surface Ships{close_quotes}, and which envisages application to a 1,500 DWT cargo vessel. The work presented here focuses on a simulation study on PEFC propulsion plant performance, and particularly on the system response to changes in load. Using a dynamic simulator composed of system components including fuel cell, various simulations were executed, to examine the performance of the system as a whole and of the individual system components under quick and large load changes such as occasioned by maneuvering operations and by racing when the propeller emerges above water in heavy sea.

Development priorities for in-space propulsion technologies

Science.gov (United States)

Johnson, Les; Meyer, Michael; Palaszewski, Bryan; Coote, David; Goebel, Dan; White, Harold

2013-02-01

During the summer of 2010, NASA's Office of Chief Technologist assembled 15 civil service teams to support the creation of a NASA integrated technology roadmap. The Aero-Space Technology Area Roadmap is an integrated set of technology area roadmaps recommending the overall technology investment strategy and prioritization for NASA's technology programs. The integrated set of roadmaps will provide technology paths needed to meet NASA's strategic goals. The roadmaps have been reviewed by senior NASA management and the National Research Council. With the exception of electric propulsion systems used for commercial communications satellite station-keeping and a handful of deep space science missions, almost all of the rocket engines in use today are chemical rockets; that is, they obtain the energy needed to generate thrust by combining reactive chemicals to create a hot gas that is expanded to produce thrust. A significant limitation of chemical propulsion is that it has a relatively low specific impulse. Numerous concepts for advanced propulsion technologies with significantly higher values of specific impulse have been developed over the past 50 years. Advanced in-space propulsion technologies will enable much more effective exploration of our solar system, near and far, and will permit mission designers to plan missions to "fly anytime, anywhere, and complete a host of science objectives at the destinations" with greater reliability and safety. With a wide range of possible missions and candidate propulsion technologies with very diverse characteristics, the question of which technologies are 'best' for future missions is a difficult one. A portfolio of technologies to allow optimum propulsion solutions for a diverse set of missions and destinations are described in the roadmap and herein.

Radioisotope electric propulsion of sciencecraft to the outer Solar System and near-interstellar space

International Nuclear Information System (INIS)

Noble, R.J.

1999-01-01

Radioisotopes have been used successfully for more than 25 years to supply the heat for thermoelectric generators on various deep-space probes. Radioisotope electric propulsion (REP) systems have been proposed as low-thrust ion propulsion units based on radioisotope electric generators and ion thrusters. The perceived liability of radioisotope electric generators for ion propulsion is their high mass. Conventional radioisotope thermoelectric generators have a specific mass of about 200 kg/kW of electric power. Many development efforts have been undertaken with the aim of reducing the specific mass of radioisotope electric systems. Recent performance estimates suggest that specific masses of 50 kg/kW may be achievable with thermophotovoltaic and alkali metal thermal-to-electric conversion generators. Powerplants constructed from these near-term radioisotope electric generators and long-life ion thrusters will likely have specific masses in the range of 100 to 200 kg/kW of thrust power if development continues over the next decade. In earlier studies, it was concluded that flight times within the Solar System are indeed insensitive to reductions in the powerplant specific mass, and that a timely scientific program of robotic planetary rendezvous and near-interstellar space missions is enabled by primary electric propulsion once the powerplant specific mass is in the range of 100 to 200 kg/kW. Flight times can be substantially reduced by using hybrid propulsion schemes that combine chemical propulsion, gravity assist, and electric propulsion. Hybrid schemes are further explored in this article to illustrate how the performance of REP is enhanced for Pluto rendezvous, heliopause orbiter, and gravitational lens missions

Numerical simulation of internal flow in mixed-flow waterjet propulsion

International Nuclear Information System (INIS)

Wu, T T; Pan, Z Y; Zhang, D Q; Jia, Y Y

2012-01-01

In order to reveal the internal flow characteristic of a mixed-flow waterjet propulsion, a mixed-flow waterjet propulsion under different conditions was simulated based on multi-reference frame(MRF), the standard k − ε turbulent model and SIMPLEC algorithm. The relationship between pump performance instability and internal flow was obtained. The numerical results showed that characteristic instability occurred at 0.65-0.67Q BEP , the reason is that the backflow on the vaned diffuser hub-side blocks the downstream flow from the impeller. Therefore, the flow separates on the pressure surface of the impeller outlet and a strong vortex is generated, then the characteristic instability appeared due to the instability of internal flow. Backflow was found in diffuser passage at 0.65 Q BEP and 0.85 Q BEP , as flow rate decreases, the backflow region and velocity increases. Pressure fluctuation at diffuser inlet and diffuser passages was severe at at 0.65 Q BEP . According to the numerical simulation, the mixed-flow waterjet propulsion has characteristic instability at partial flow rate condition.

Prospective application of laser plasma propulsion in rocket technology

International Nuclear Information System (INIS)

Lu Xin; Zhang Jie; Li Yingjun

2002-01-01

Interest in laser plasma propulsion is growing intensively. The interaction of high intensity short laser pulses with materials can produce plasma expansion with a velocity of hundreds of km/s. The specific impulse of ablative laser propulsion can be many tens of times greater than that of chemical rockets. The development and potential application of laser plasma propulsion are discussed

Misconceptions of Electric Propulsion Aircraft and Their Emergent Aviation Markets

Science.gov (United States)

Moore, Mark D.; Fredericks, Bill

2014-01-01

Over the past several years there have been aircraft conceptual design and system studies that have reached conflicting conclusions relating to the feasibility of full and hybrid electric aircraft. Some studies and propulsion discipline experts have claimed that battery technologies will need to improve by 10 to 20 times before electric aircraft can effectively compete with reciprocating or turbine engines. However, such studies have approached comparative assessments without understanding the compelling differences that electric propulsion offers, how these technologies will fundamentally alter the way propulsion integration is approached, or how these new technologies can not only compete but far exceed existing propulsion solutions in many ways at battery specific energy densities of only 400 watt hours per kilogram. Electric propulsion characteristics offer the opportunity to achieve 4 to 8 time improvements in energy costs with dramatically lower total operating costs, while dramatically improving efficiency, community noise, propulsion system reliability and safety through redundancy, as well as life cycle Green House Gas emissions. Integration of electric propulsion will involve far greater degrees of distribution than existing propulsion solutions due to their compact and scale-free nature to achieve multi-disciplinary coupling and synergistic integration with the aerodynamics, highlift system, acoustics, vehicle control, balance, and aeroelasticity. Appropriate metrics of comparison and differences in analysis/design tools are discussed while comparing electric propulsion to other disruptive technologies. For several initial applications, battery energy density is already sufficient for competitive products, and for many additional markets energy densities will likely be adequate within the next 7 years for vibrant introduction. Market evolution and early adopter markets are discussed, along with the investment areas that will fill technology gaps and

A review of underwater bio-mimetic propulsion: cruise and fast-start

Science.gov (United States)

Chao, Li-Ming; Cao, Yong-Hui; Pan, Guang

2017-08-01

This paper reviews recent developments in the understanding of underwater bio-mimetic propulsion. Two impressive models of underwater propulsion are considered: cruise and fast-start. First, we introduce the progression of bio-mimetic propulsion, especially underwater propulsion, where some primary conceptions are touched upon. Second, the understanding of flapping foils, considered as one of the most efficient cruise styles of aquatic animals, is introduced, where the effect of kinematics and the shape and flexibility of foils on generating thrust are elucidated respectively. Fast-start propulsion is always exhibited when predator behaviour occurs, and we provide an explicit introduction of corresponding zoological experiments and numerical simulations. We also provide some predictions about underwater bio-mimetic propulsion.

A review of underwater bio-mimetic propulsion: cruise and fast-start

Energy Technology Data Exchange (ETDEWEB)

Chao, Li-Ming; Cao, Yong-Hui; Pan, Guang, E-mail: PanGuang_010@163.com [School of Marine Science and Technology, Northwestern Polytechnical University, Xian 710072 (China)

2017-08-15

This paper reviews recent developments in the understanding of underwater bio-mimetic propulsion. Two impressive models of underwater propulsion are considered: cruise and fast-start. First, we introduce the progression of bio-mimetic propulsion, especially underwater propulsion, where some primary conceptions are touched upon. Second, the understanding of flapping foils, considered as one of the most efficient cruise styles of aquatic animals, is introduced, where the effect of kinematics and the shape and flexibility of foils on generating thrust are elucidated respectively. Fast-start propulsion is always exhibited when predator behaviour occurs, and we provide an explicit introduction of corresponding zoological experiments and numerical simulations. We also provide some predictions about underwater bio-mimetic propulsion. (review)

Overview of the NASA Environmentally Responsible Aviation Project's Propulsion Technology Portfolio

Science.gov (United States)

Suder, Kenneth L.

2012-01-01

The NASA Environmentally Responsible Aviation (ERA) Project is focused on developing and demonstrating integrated systems technologies to TRL 4-6 by 2020 that enable reduced fuel burn, emissions, and noise for futuristic air vehicles. The specific goals aim to simultaneously reduce fuel burn by 50%, reduce Landing and Take-off Nitrous Oxides emissions by 75% relative to the CAEP 6 guidelines, and reduce cumulative noise by 42 Decibels relative to the Stage 4 guidelines. These goals apply to the integrated vehicle and propulsion system and are based on a reference mission of 3000nm flight of a Boeing 777-200 with GE90 engines. This paper will focus primarily on the ERA propulsion technology portfolio, which consists of advanced combustion, propulsor, and core technologies to enable these integrated air vehicle systems goals. An overview of the ERA propulsion technologies will be described and the status and results to date will be presented.

Torque capability improvement of sensorless FOC induction machine in field weakening for propulsion purposes

Directory of Open Access Journals (Sweden)

Nisha G.K.

2017-05-01

Full Text Available An electric propulsion system is generally based on torque controlled electric drive and DC series motors are traditionally used for propulsion system. Induction machines, which are reliable, low cost and have less maintenance, satisfy the characteristics of the propulsion and reinstating the DC series motor. Field oriented control (FOC of induction machines can decouple its torque control from field control which allows the induction motor to act like a separately excited DC motor. In this paper, the characteristic control of induction motor is achieved through appropriate design modification of induction motor by varying magnetizing current to produce maximum torque in field weakening (FW region. Thus to improve the torque capability of induction machine in FW region by varying machine parameters. The sensorless operation of the induction motor is carried out by adopting model reference adaptive system (MRAS using sliding mode control (SMC and a FW algorithm based on the voltage and current constraints. The simulation of the induction motor drive models based on the design options have been carried out and analyzed the simulation results.

Propulsion of swimming microrobots inspired by metachronal waves in ciliates: from biology to material specifications

International Nuclear Information System (INIS)

Palagi, Stefano; Mazzolai, Barbara; Beccai, Lucia; Jager, Edwin WH

2013-01-01

The quest for swimming microrobots originates from possible applications in medicine, especially involving navigation in bodily fluids. Swimming microorganisms have become a source of inspiration because their propulsion mechanisms are effective in the low-Reynolds number regime. In this study, we address a propulsion mechanism inspired by metachronal waves, i.e. the spontaneous coordination of cilia leading to the fast swimming of ciliates. We analyse the biological mechanism (referring to its particular embodiment in Paramecium caudatum), and we investigate the contribution of its main features to the swimming performance, through a three-dimensional finite-elements model, in order to develop a simplified, yet effective artificial design. We propose a bioinspired propulsion mechanism for a swimming microrobot based on a continuous cylindrical electroactive surface exhibiting perpendicular wave deformations travelling longitudinally along its main axis. The simplified propulsion mechanism is conceived specifically for microrobots that embed a micro-actuation system capable of executing the bioinspired propulsion (self-propelled microrobots). Among the available electroactive polymers, we select polypyrrole as the possible actuation material and we assess it for this particular embodiment. The results are used to appoint target performance specifications for the development of improved or new electroactive materials to attain metachronal-waves-like propulsion. (paper)

Propulsion of swimming microrobots inspired by metachronal waves in ciliates: from biology to material specifications.

Science.gov (United States)

Palagi, Stefano; Jager, Edwin W H; Mazzolai, Barbara; Beccai, Lucia

2013-12-01

The quest for swimming microrobots originates from possible applications in medicine, especially involving navigation in bodily fluids. Swimming microorganisms have become a source of inspiration because their propulsion mechanisms are effective in the low-Reynolds number regime. In this study, we address a propulsion mechanism inspired by metachronal waves, i.e. the spontaneous coordination of cilia leading to the fast swimming of ciliates. We analyse the biological mechanism (referring to its particular embodiment in Paramecium caudatum), and we investigate the contribution of its main features to the swimming performance, through a three-dimensional finite-elements model, in order to develop a simplified, yet effective artificial design. We propose a bioinspired propulsion mechanism for a swimming microrobot based on a continuous cylindrical electroactive surface exhibiting perpendicular wave deformations travelling longitudinally along its main axis. The simplified propulsion mechanism is conceived specifically for microrobots that embed a micro-actuation system capable of executing the bioinspired propulsion (self-propelled microrobots). Among the available electroactive polymers, we select polypyrrole as the possible actuation material and we assess it for this particular embodiment. The results are used to appoint target performance specifications for the development of improved or new electroactive materials to attain metachronal-waves-like propulsion.

Shoulder pain and jerk during recovery phase of manual wheelchair propulsion.

Science.gov (United States)

Jayaraman, Chandrasekaran; Beck, Carolyn L; Sosnoff, Jacob J

2015-11-05

Repetitive loading of the upper limb due to wheelchair propulsion plays a leading role in the development of shoulder pain in manual wheelchair users (mWCUs). There has been minimal inquiry on understanding wheelchair propulsion kinematics from a human movement ergonomics perspective. This investigation employs an ergonomic metric, jerk, to characterize the recovery phase kinematics of two recommended manual wheelchair propulsion patterns: semi-circular and the double loop. Further it examines if jerk is related to shoulder pain in mWCUs. Data from 22 experienced adult mWCUs was analyzed for this study (semi-circular: n=12 (pain/without-pain:6/6); double-loop: n=10 (pain/without-pain:4/6)). Participants propelled their own wheelchair fitted with SMARTWheels on a roller dynamometer at 1.1 m/s for 3 min. Kinematic and kinetic data of the upper limbs were recorded. Three dimensional absolute jerk experienced at the shoulder, elbow and wrist joint during the recovery phase of wheelchair propulsion were computed. Two-way ANOVAs were conducted with the recovery pattern type and shoulder pain as between group factors. (1) Individuals using a semi-circular pattern experienced lower jerk at their arm joints than those using a double loop pattern (Ppropulsion was able to distinguish between pattern types (semi-circular and double loop) and the presence of shoulder pain. Jerk provides novel insights into wheelchair propulsion kinematics and in the future it may be beneficial to incorporate jerk based metric into rehabilitation practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study.

Science.gov (United States)

Chlapek, Petr; Redova, Martina; Zitterbart, Karel; Hermanova, Marketa; Sterba, Jaroslav; Veselska, Renata

2010-05-11

We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2) and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (COX). This study is a continuation of our previous work confirming the possibility of enhancing ATRA-induced cell differentiation in these cell lines by the application of LOX/COX inhibitors and brings more detailed information concerning the mechanisms of the enhancement of ATRA-induced differentiation of neuroblastoma cells. Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor on cyclooxygenase-2, were used in this study. Expression profiling was performed using Human Cancer Oligo GEArray membranes that cover 440 cancer-related genes. Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement. Furthermore, we also found overexpression of some genes in the same cell line (SK-N-BE(2) or SH-SY5Y) after combined treatment with both ATRA and CA, or ATRA and CX. Finally, we also detected that gene expression was changed after treatment with the same inhibitor (CA or CX) in combination with ATRA in both cell lines. Obtained results confirmed our initial hypothesis of the common mechanism of enhancement in ATRA-induced cell differentiation via inhibition of arachidonic acid metabolic pathway.

Is effective force application in handrim wheelchair propulsion also efficient?

Science.gov (United States)

Bregman, D J J; van Drongelen, S; Veeger, H E J

2009-01-01

Efficiency in manual wheelchair propulsion is low, as is the fraction of the propulsion force that is attributed to the moment of propulsion of the wheelchair. In this study we tested the hypothesis that a tangential propulsion force direction leads to an increase in physiological cost, due to (1) the sub-optimal use of elbow flexors and extensors, and/or (2) the necessity of preventing of glenohumeral subluxation. Five able-bodied and 11 individuals with a spinal cord injury propelled a wheelchair while kinematics and kinetics were collected. The results were used to perform inverse dynamical simulations with input of (1) the experimentally obtained propulsion force, and (2) only the tangential component of that force. In the tangential force condition the physiological cost was over 30% higher, while the tangential propulsion force was only 75% of the total experimental force. According to model estimations, the tangential force condition led to more co-contraction around the elbow, and a higher power production around the shoulder joint. The tangential propulsion force led to a significant, but small 4% increase in necessity for the model to compensate for glenohumeral subluxation, which indicates that this is not a likely cause of the decrease in efficiency. The present findings support the hypothesis that the observed force direction in wheelchair propulsion is a compromise between efficiency and the constraints imposed by the wheelchair-user system. This implies that training should not be aimed at optimization of the propulsion force, because this may be less efficient and more straining for the musculoskeletal system.

The NASA In-Space Propulsion Technology Project, Products, and Mission Applicability

Science.gov (United States)

Anderson, David J.; Pencil, Eric; Liou, Larry; Dankanich, John; Munk, Michelle M.; Kremic, Tibor

2009-01-01

The In-Space Propulsion Technology (ISPT) Project, funded by NASA s Science Mission Directorate (SMD), is continuing to invest in propulsion technologies that will enable or enhance NASA robotic science missions. This overview provides development status, near-term mission benefits, applicability, and availability of in-space propulsion technologies in the areas of aerocapture, electric propulsion, advanced chemical thrusters, and systems analysis tools. Aerocapture investments improved: guidance, navigation, and control models of blunt-body rigid aeroshells; atmospheric models for Earth, Titan, Mars, and Venus; and models for aerothermal effects. Investments in electric propulsion technologies focused on completing NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6 to 7 kW throttle-able gridded ion system. The project is also concluding its High Voltage Hall Accelerator (HiVHAC) mid-term product specifically designed for a low-cost electric propulsion option. The primary chemical propulsion investment is on the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance for lower cost. The project is also delivering products to assist technology infusion and quantify mission applicability and benefits through mission analysis and tools. In-space propulsion technologies are applicable, and potentially enabling for flagship destinations currently under evaluation, as well as having broad applicability to future Discovery and New Frontiers mission solicitations.

Is cardiovascular disease in patients with diabetes associated with serum levels of MMP-2, LOX, and the elastin degradation products ELM and ELM-2?

Science.gov (United States)

Preil, Simone Andrea Rørdam; Thorsen, Anne-Sofie Faarvang; Christiansen, Anne Lindegaard; Poulsen, Mikael Kjær; Karsdal, Morten Asser; Leeming, Diana Julie; Rasmussen, Lars Melholt

2017-11-01

Diabetes mellitus type 2 (T2DM) is a significant risk factor for the development of cardiovascular diseases (CVDs). In a previous microarray study of internal mammary arteries from patients with and without T2DM, we observed several elastin-related genes with altered mRNA-expression in diabetic patients, namely matrix metalloproteinase 2 (MMP-2), lysyl oxidase (LOX) and elastin itself. In this study we investigate whether the serum concentrations of elastin-related proteins correlate to signs of CVD in patients with T2DM. Blood samples from 302 type 2 diabetic patients were analysed for MMP-2, LOX, and the elastin degradation products ELM and ELM2. The results were investigated for correlations to signs of CVD in different vascular territories, as determined by myocardial perfusion scintigraphy, carotid artery thickness and ankle-brachial blood pressure index. T2DM patients with peripheral arterial disease (low ankle-brachial index) (PAD) display higher levels of MMP-2 and ELM compared to patients without PAD. However, none of the proteins or degradation products correlated with myocardial ischemia or a combined measure of CVD-signs, including myocardial ischemia, increased carotid thickness and decreased ankle-brachial blood pressure. Our results suggest that the diabetic environment affects the circulating amounts of MMP-2 and ELM in patients with PAD. However, the same connection could not be seen in diabetic patients with CVD broadly identified in three vascular territories. LOX and ELM-2 did not correlate to any type of CVD. Overall, serum levels of elastin-related molecules are only remotely related to CVD in type 2 diabetes.

LO2/LH2 propulsion for outer planet orbiter spacecraft

Science.gov (United States)

Garrison, P. W.; Sigurdson, K. B.

1983-01-01

Galileo class orbiter missions (750-1500 kg) to the outer planets require a large postinjection delta-V for improved propulsion performance. The present investigation shows that a pump-fed low thrust LO2/LH2 propulsion system can provide a significantly larger net on-orbit mass for a given delta-V than a state-of-the-art earth storable, N2O4/monomethylhydrazine pressure-fed propulsion system. A description is given of a conceptual design for a LO2/LH2 pump-fed propulsion system developed for a Galileo class mission to the outer planets. Attention is given to spacecraft configuration, details regarding the propulsion system, the thermal control of the cryogenic propellants, and aspects of mission performance.

Study of muscle cell dedifferentiation after skeletal muscle injury of mice with a Cre-Lox system.

Science.gov (United States)

Mu, Xiaodong; Peng, Hairong; Pan, Haiying; Huard, Johnny; Li, Yong

2011-02-03

Dedifferentiation of muscle cells in the tissue of mammals has yet to be observed. One of the challenges facing the study of skeletal muscle cell dedifferentiation is the availability of a reliable model that can confidentially distinguish differentiated cell populations of myotubes and non-fused mononuclear cells, including stem cells that can coexist within the population of cells being studied. In the current study, we created a Cre/Lox-β-galactosidase system, which can specifically tag differentiated multinuclear myotubes and myotube-generated mononuclear cells based on the activation of the marker gene, β-galactosidase. By using this system in an adult mouse model, we found that β-galactosidase positive mononuclear cells were generated from β-galactosidase positive multinuclear myofibers upon muscle injury. We also demonstrated that these mononuclear cells can develop into a variety of different muscle cell lineages, i.e., myoblasts, satellite cells, and muscle derived stem cells. These novel findings demonstrated, for the first time, that cellular dedifferentiation of skeletal muscle cells actually occurs in mammalian skeletal muscle following traumatic injury in vivo.

A Novel AHRS Inertial Sensor-Based Algorithm for Wheelchair Propulsion Performance Analysis

Directory of Open Access Journals (Sweden)

Jonathan Bruce Shepherd

2016-08-01

Full Text Available With the increasing rise of professionalism in sport, athletes, teams, and coaches are looking to technology to monitor performance in both games and training in order to find a competitive advantage. The use of inertial sensors has been proposed as a cost effective and adaptable measurement device for monitoring wheelchair kinematics; however, the outcomes are dependent on the reliability of the processing algorithms. Though there are a variety of algorithms that have been proposed to monitor wheelchair propulsion in court sports, they all have limitations. Through experimental testing, we have shown the Attitude and Heading Reference System (AHRS-based algorithm to be a suitable and reliable candidate algorithm for estimating velocity, distance, and approximating trajectory. The proposed algorithm is computationally inexpensive, agnostic of wheel camber, not sensitive to sensor placement, and can be embedded for real-time implementations. The research is conducted under Griffith University Ethics (GU Ref No: 2016/294.

Initial Skill Acquisition of Handrim Wheelchair Propulsion: A New Perspective.

Science.gov (United States)

Vegter, Riemer J K; de Groot, Sonja; Lamoth, Claudine J; Veeger, Dirkjan Hej; van der Woude, Lucas H V

2014-01-01

To gain insight into cyclic motor learning processes, hand rim wheelchair propulsion is a suitable cyclic task, to be learned during early rehabilitation and novel to almost every individual. To propel in an energy efficient manner, wheelchair users must learn to control bimanually applied forces onto the rims, preserving both speed and direction of locomotion. The purpose of this study was to evaluate mechanical efficiency and propulsion technique during the initial stage of motor learning. Therefore, 70 naive able-bodied men received 12-min uninstructed wheelchair practice, consisting of three 4-min blocks separated by 2 min rest. Practice was performed on a motor-driven treadmill at a fixed belt speed and constant power output relative to body mass. Energy consumption and the kinetics of propulsion technique were continuously measured. Participants significantly increased their mechanical efficiency and changed their propulsion technique from a high frequency mode with a lot of negative work to a longer-slower movement pattern with less power losses. Furthermore a multi-level model showed propulsion technique to relate to mechanical efficiency. Finally improvers and non-improvers were identified. The non-improving group was already more efficient and had a better propulsion technique in the first block of practice (i.e., the fourth minute). These findings link propulsion technique to mechanical efficiency, support the importance of a correct propulsion technique for wheelchair users and show motor learning differences.

Regional gene expression of LOX-1, VCAM-1, and ICAM-1 in aorta of HIV-1 transgenic rats.

Directory of Open Access Journals (Sweden)

Anne Mette Fisker Hag

Full Text Available BACKGROUND: Increased prevalence of atherosclerotic cardiovascular disease in HIV-infected patients has been observed. The cause of this accelerated atherosclerosis is a matter of controversy. As clinical studies are complicated by a multiplicity of risk-factors and a low incidence of hard endpoints, studies in animal models could be attractive alternatives. METHODOLOGY/PRINCIPAL FINDINGS: We evaluated gene expression of lectin-like oxidized-low-density-lipoprotein receptor-1 (LOX-1, vascular cell adhesion molecule-1 (VCAM-1, and intercellular adhesion molecule-1 (ICAM-1 in HIV-1 transgenic (HIV-1Tg rats; these genes are all thought to play important roles in early atherogenesis. Furthermore, the plasma level of sICAM-1 was measured. We found that gene expressions of LOX-1 and VCAM-1 were higher in the aortic arch of HIV-1Tg rats compared to controls. Also, the level of sICAM-1 was elevated in the HIV-1Tg rats compared to controls, but the ICAM-1 gene expression profile did not show any differences between the groups. CONCLUSIONS/SIGNIFICANCE: HIV-1Tg rats have gene expression patterns indicating endothelial dysfunction and accelerated atherosclerosis in aorta, suggesting that HIV-infection per se may cause atherosclerosis. This transgenic rat model may be a very promising model for further studies of the pathophysiology behind HIV-associated cardiovascular disease.

Swimming mechanics and propulsive efficiency in the chambered nautilus

Science.gov (United States)

Neil, Thomas R.; Askew, Graham N.

2018-02-01

The chambered nautilus (Nautilus pompilius) encounters severe environmental hypoxia during diurnal vertical movements in the ocean. The metabolic cost of locomotion (Cmet) and swimming performance depend on how efficiently momentum is imparted to the water and how long on-board oxygen stores last. While propulsive efficiency is generally thought to be relatively low in jet propelled animals, the low Cmet in Nautilus indicates that this is not the case. We measured the wake structure in Nautilus during jet propulsion swimming, to determine their propulsive efficiency. Animals swam with either an anterior-first or posterior-first orientation. With increasing swimming speed, whole cycle propulsive efficiency increased during posterior-first swimming but decreased during anterior-first swimming, reaching a maximum of 0.76. The highest propulsive efficiencies were achieved by using an asymmetrical contractile cycle in which the fluid ejection phase was relatively longer than the refilling phase, reducing the volume flow rate of the ejected fluid. Our results demonstrate that a relatively high whole cycle propulsive efficiency underlies the low Cmet in Nautilus, representing a strategy to reduce the metabolic demands in an animal that spends a significant part of its daily life in a hypoxic environment.

Hybrid rocket propulsion systems for outer planet exploration missions

Science.gov (United States)

Jens, Elizabeth T.; Cantwell, Brian J.; Hubbard, G. Scott

2016-11-01

Outer planet exploration missions require significant propulsive capability, particularly to achieve orbit insertion. Missions to explore the moons of outer planets place even more demanding requirements on propulsion systems, since they involve multiple large ΔV maneuvers. Hybrid rockets present a favorable alternative to conventional propulsion systems for many of these missions. They typically enjoy higher specific impulse than solids, can be throttled, stopped/restarted, and have more flexibility in their packaging configuration. Hybrids are more compact and easier to throttle than liquids and have similar performance levels. In order to investigate the suitability of these propulsion systems for exploration missions, this paper presents novel hybrid motor designs for two interplanetary missions. Hybrid propulsion systems for missions to Europa and Uranus are presented and compared to conventional in-space propulsion systems. The hybrid motor design for each of these missions is optimized across a range of parameters, including propellant selection, O/F ratio, nozzle area ratio, and chamber pressure. Details of the design process are described in order to provide guidance for researchers wishing to evaluate hybrid rocket motor designs for other missions and applications.

MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1

Science.gov (United States)

Chen, Zhibo; Wang, Mian; He, Qiong; Li, Zilun; Zhao, Yang; Wang, Wenjian; Ma, Jieyi; Li, Yongxin; Chang, Guangqi

2017-01-01

Oxidized low-density lipoprotein (ox-LDL) is a major and critical mediator of atherosclerosis, and the underlying mechanism is thought to involve the ox-LDL-induced dysfunction of endothelial cells (ECs). MicroRNAs (miRNAs), which are a group of small non-coding RNA molecules that post-transcriptionally regulate the expression of target genes, have been associated with diverse cellular functions and the pathogenesis of various diseases, including atherosclerosis. miRNA-98 (miR-98) has been demonstrated to be involved in the regulation of cellular apoptosis; however, the role of miR-98 in ox-LDL-induced dysfunction of ECs and atherosclerosis has yet to be elucidated. Therefore, the present study aimed to investigate the role of miR-98 in ox-LDL-induced dysfunction of ECs and the underlying mechanism. It was demonstrated that miR-98 expression was markedly downregulated in ox-LDL-treated human umbilical vein ECs (HUVECs) and that miR-98 promoted the proliferation and alleviated apoptosis of HUVECs exposed to ox-LDL. In addition, the results demonstrated that lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) was a direct target of miR-98 in HUVECs, as indicated by a luciferase assay. The results of the present study suggested that miR-98 may inhibit the uptake of toxic ox-LDL, maintain HUVEC proliferation and protect HUVECs against apoptosis via the suppression of LOX-1. PMID:28565756

Volume Dynamics Propulsion System Modeling for Supersonics Vehicle Research

Science.gov (United States)

Kopasakis, George; Connolly, Joseph W.; Paxson, Daniel E.; Ma, Peter

2010-01-01

Under the NASA Fundamental Aeronautics Program the Supersonics Project is working to overcome the obstacles to supersonic commercial flight. The proposed vehicles are long slim body aircraft with pronounced aero-servo-elastic modes. These modes can potentially couple with propulsion system dynamics; leading to performance challenges such as aircraft ride quality and stability. Other disturbances upstream of the engine generated from atmospheric wind gusts, angle of attack, and yaw can have similar effects. In addition, for optimal propulsion system performance, normal inlet-engine operations are required to be closer to compressor stall and inlet unstart. To study these phenomena an integrated model is needed that includes both airframe structural dynamics as well as the propulsion system dynamics. This paper covers the propulsion system component volume dynamics modeling of a turbojet engine that will be used for an integrated vehicle Aero-Propulso-Servo-Elastic model and for propulsion efficiency studies.

Chemical rocket propulsion a comprehensive survey of energetic materials

CERN Document Server

Shimada, Toru; Sinditskii, Valery; Calabro, Max

2017-01-01

Developed and expanded from the work presented at the New Energetic Materials and Propulsion Techniques for Space Exploration workshop in June 2014, this book contains new scientific results, up-to-date reviews, and inspiring perspectives in a number of areas related to the energetic aspects of chemical rocket propulsion. This collection covers the entire life of energetic materials from their conceptual formulation to practical manufacturing; it includes coverage of theoretical and experimental ballistics, performance properties, as well as laboratory-scale and full system-scale, handling, hazards, environment, ageing, and disposal. Chemical Rocket Propulsion is a unique work, where a selection of accomplished experts from the pioneering era of space propulsion and current technologists from the most advanced international laboratories discuss the future of chemical rocket propulsion for access to, and exploration of, space. It will be of interest to both postgraduate and final-year undergraduate students in...

Effects of visual feedback-induced variability on motor learning of handrim wheelchair propulsion.

Science.gov (United States)

Leving, Marika T; Vegter, Riemer J K; Hartog, Johanneke; Lamoth, Claudine J C; de Groot, Sonja; van der Woude, Lucas H V

2015-01-01

It has been suggested that a higher intra-individual variability benefits the motor learning of wheelchair propulsion. The present study evaluated whether feedback-induced variability on wheelchair propulsion technique variables would also enhance the motor learning process. Learning was operationalized as an improvement in mechanical efficiency and propulsion technique, which are thought to be closely related during the learning process. 17 Participants received visual feedback-based practice (feedback group) and 15 participants received regular practice (natural learning group). Both groups received equal practice dose of 80 min, over 3 weeks, at 0.24 W/kg at a treadmill speed of 1.11 m/s. To compare both groups the pre- and post-test were performed without feedback. The feedback group received real-time visual feedback on seven propulsion variables with instruction to manipulate the presented variable to achieve the highest possible variability (1st 4-min block) and optimize it in the prescribed direction (2nd 4-min block). To increase motor exploration the participants were unaware of the exact variable they received feedback on. Energy consumption and the propulsion technique variables with their respective coefficient of variation were calculated to evaluate the amount of intra-individual variability. The feedback group, which practiced with higher intra-individual variability, improved the propulsion technique between pre- and post-test to the same extent as the natural learning group. Mechanical efficiency improved between pre- and post-test in the natural learning group but remained unchanged in the feedback group. These results suggest that feedback-induced variability inhibited the improvement in mechanical efficiency. Moreover, since both groups improved propulsion technique but only the natural learning group improved mechanical efficiency, it can be concluded that the improvement in mechanical efficiency and propulsion technique do not always appear

Effects of visual feedback-induced variability on motor learning of handrim wheelchair propulsion.

Directory of Open Access Journals (Sweden)

Marika T Leving

Full Text Available It has been suggested that a higher intra-individual variability benefits the motor learning of wheelchair propulsion. The present study evaluated whether feedback-induced variability on wheelchair propulsion technique variables would also enhance the motor learning process. Learning was operationalized as an improvement in mechanical efficiency and propulsion technique, which are thought to be closely related during the learning process.17 Participants received visual feedback-based practice (feedback group and 15 participants received regular practice (natural learning group. Both groups received equal practice dose of 80 min, over 3 weeks, at 0.24 W/kg at a treadmill speed of 1.11 m/s. To compare both groups the pre- and post-test were performed without feedback. The feedback group received real-time visual feedback on seven propulsion variables with instruction to manipulate the presented variable to achieve the highest possible variability (1st 4-min block and optimize it in the prescribed direction (2nd 4-min block. To increase motor exploration the participants were unaware of the exact variable they received feedback on. Energy consumption and the propulsion technique variables with their respective coefficient of variation were calculated to evaluate the amount of intra-individual variability.The feedback group, which practiced with higher intra-individual variability, improved the propulsion technique between pre- and post-test to the same extent as the natural learning group. Mechanical efficiency improved between pre- and post-test in the natural learning group but remained unchanged in the feedback group.These results suggest that feedback-induced variability inhibited the improvement in mechanical efficiency. Moreover, since both groups improved propulsion technique but only the natural learning group improved mechanical efficiency, it can be concluded that the improvement in mechanical efficiency and propulsion technique do not

National Institute for Rocket Propulsion Systems 2012 Annual Report: A Year of Progress and Challenge

Science.gov (United States)

Thomas, L. Dale; Doreswamy, Rajiv; Fry, Emma Kiele

2013-01-01

The National Institute for Rocket Propulsion Systems (NIRPS) maintains and advances U.S. leadership in all aspects of rocket propulsion for defense, civil, and commercial uses. The Institute's creation is in response to widely acknowledged concerns about the U.S. rocket propulsion base dating back more than a decade. U.S. leadership in rocket and missile propulsion is threatened by long-term industry downsizing, a shortage of new solid and liquid propulsion programs, limited ability to attract and retain fresh talent, and discretionary federal budget pressures. Numerous trade and independent studies cite erosion of this capability as a threat to national security and the U.S. economy resulting in a loss of global competitiveness for the U.S. propulsion industry. This report covers the period between May 2011 and December 2012, which includes the creation and transition to operations of NIRPS. All subsequent reports will be annual. The year 2012 has been an eventful one for NIRPS. In its first full year, the new team overcame many obstacles and explored opportunities to ensure the institute has a firm foundation for the future. NIRPS is now an active organization making contributions to the development, sustainment, and strategy of the rocket propulsion industry in the United States. This report describes the actions taken by the NIRPS team to determine the strategy, organizational structure, and goals of the Institute. It also highlights key accomplishments, collaborations with other organizations, and the strategic framework for the Institute.

Integrated Propulsion Data System Public Web Site

Science.gov (United States)

Hamilton, Kimberly

2001-01-01

The Integrated Propulsion Data System's (IPDS) focus is to provide technologically-advanced philosophies of doing business at SSC that will enhance the existing operations, engineering and management strategies and provide insight and metrics to assess their daily impacts, especially as related to the Propulsion Test Directorate testing scenarios for the 21st Century.

Configurations of hybrid-electric cars propulsion systems

OpenAIRE

Cundev, Dobri; Sarac, Vasilija; Stefanov, Goce

2011-01-01

Over the last few years, hybrid electric cars have taken significant role in automotive market. There are successful technological solutions of hybrid-electric propulsion systems implemented in commercial passenger cars. Every automobile manufacturer of hybrid vehicles has unique hybrid propulsion system. In this paper, all implemented systems are described, analyzed and compared.

Fusion Reactions and Matter-Antimatter Annihilation for Space Propulsion

Science.gov (United States)

2005-07-13

FUSION REACTIONS AND MATTER- ANTIMATTER ANNIHILATION FOR SPACE PROPULSION Claude DEUTSCH LPGP (UMR-CNRS 8578), Bât. 210, UPS, 91405 Orsay...REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE šFusion Reactions And Matter- Antimatter Annihilation For Space Propulsion 5a...which is possible with successful MCF or ICF. Appropriate vessel designs will be presented for fusion as well as for antimatter propulsion. In

Space Nuclear Thermal Propulsion Test Facilities Subpanel. Final report

International Nuclear Information System (INIS)

Allen, G.C.; Warren, J.W.; Martinell, J.; Clark, J.S.; Perkins, D.

1993-04-01

On 20 Jul. 1989, in commemoration of the 20th anniversary of the Apollo 11 lunar landing, President George Bush proclaimed his vision for manned space exploration. He stated, 'First for the coming decade, for the 1990's, Space Station Freedom, the next critical step in our space endeavors. And next, for the new century, back to the Moon. Back to the future. And this time, back to stay. And then, a journey into tomorrow, a journey to another planet, a manned mission to Mars.' On 2 Nov. 1989, the President approved a national space policy reaffirming the long range goal of the civil space program: to 'expand human presence and activity beyond Earth orbit into the solar system.' And on 11 May 1990, he specified the goal of landing Astronauts on Mars by 2019, the 50th anniversary of man's first steps on the Moon. To safely and ever permanently venture beyond near Earth environment as charged by the President, mankind must bring to bear extensive new technologies. These include heavy lift launch capability from Earth to low-Earth orbit, automated space rendezvous and docking of large masses, zero gravity countermeasures, and closed loop life support systems. One technology enhancing, and perhaps enabling, the piloted Mars missions is nuclear propulsion, with great benefits over chemical propulsion. Asserting the potential benefits of nuclear propulsion, NASA has sponsored workshops in Nuclear Electric Propulsion and Nuclear Thermal Propulsion and has initiated a tri-agency planning process to ensure that appropriate resources are engaged to meet this exciting technical challenge. At the core of this planning process, NASA, DOE, and DOD established six Nuclear Propulsion Technical Panels in 1991 to provide groundwork for a possible tri-agency Nuclear Propulsion Program and to address the President's vision by advocating an aggressive program in nuclear propulsion. To this end the Nuclear Electric Propulsion Technology Panel has focused it energies

Mechanical efficiency of two commercial lever-propulsion mechanisms for manual wheelchair locomotion.

Science.gov (United States)

Lui, Jordon; MacGillivray, Megan K; Sheel, A William; Jeyasurya, Jeswin; Sadeghi, Mahsa; Sawatzky, Bonita Jean

2013-01-01

The purpose of this study was to (1) evaluate the mechanical efficiency (ME) of two commercially available lever-propulsion mechanisms for wheelchairs and (2) compare the ME of lever propulsion with hand rim propulsion within the same wheelchair. Of the two mechanisms, one contained a torsion spring while the other used a roller clutch design. We hypothesized that the torsion spring mechanism would increase the ME of propulsion due to a passive recovery stroke enabled by the mechanism. Ten nondisabled male participants with no prior manual wheeling experience performed submaximal exercise tests using both lever-propulsion mechanisms and hand rim propulsion on two different wheelchairs. Cardiopulmonary parameters including oxygen uptake (VO2), heart rate (HR), and energy expenditure (En) were determined. Total external power (Pext) was measured using a drag test protocol. ME was determined by the ratio of Pext to En. Results indicated no significant effect of lever-propulsion mechanism for all physiological measures tested. This suggests that the torsion spring did not result in a physiological benefit compared with the roller clutch mechanism. However, both lever-propulsion mechanisms showed decreased VO2 and HR and increased ME (as a function of slope) compared with hand rim propulsion (p propulsion mechanisms tested are more mechanically efficient than conventional hand rim propulsion, especially when slopes are encountered.

Muscle forces analysis in the shoulder mechanism during wheelchair propulsion.

Science.gov (United States)

Lin, Hwai-Ting; Su, Fong-Chin; Wu, Hong-Wen; An, Kai-Nan

2004-01-01

This study combines an ergometric wheelchair, a six-camera video motion capture system and a prototype computer graphics based musculoskeletal model (CGMM) to predict shoulder joint loading, muscle contraction force per muscle and the sequence of muscular actions during wheelchair propulsion, and also to provide an animated computer graphics model of the relative interactions. Five healthy male subjects with no history of upper extremity injury participated. A conventional manual wheelchair was equipped with a six-component load cell to collect three-dimensional forces and moments experienced by the wheel, allowing real-time measurement of hand/rim force applied by subjects during normal wheelchair operation. An ExpertVision six-camera video motion capture system collected trajectory data of markers attached on anatomical positions. The CGMM was used to simulate and animate muscle action by using an optimization technique combining observed muscular motions with physiological constraints to estimate muscle contraction forces during wheelchair propulsion. The CGMM provides results that satisfactorily match the predictions of previous work, disregarding minor differences which presumably result from differing experimental conditions, measurement technologies and subjects. Specifically, the CGMM shows that the supraspinatus, infraspinatus, anterior deltoid, pectoralis major and biceps long head are the prime movers during the propulsion phase. The middle and posterior deltoid and supraspinatus muscles are responsible for arm return during the recovery phase. CGMM modelling shows that the rotator cuff and pectoralis major play an important role during wheelchair propulsion, confirming the known risk of injury for these muscles during wheelchair propulsion. The CGMM successfully transforms six-camera video motion capture data into a technically useful and visually interesting animated video model of the shoulder musculoskeletal system. The CGMM further yields accurate

Xenon Acquisition Strategies for High-Power Electric Propulsion NASA Missions

Science.gov (United States)

Herman, Daniel A.; Unfried, Kenneth G.

2015-01-01

Solar electric propulsion (SEP) has been used for station-keeping of geostationary communications satellites since the 1980s. Solar electric propulsion has also benefitted from success on NASA Science Missions such as Deep Space One and Dawn. The xenon propellant loads for these applications have been in the 100s of kilograms range. Recent studies performed for NASA's Human Exploration and Operations Mission Directorate (HEOMD) have demonstrated that SEP is critically enabling for both near-term and future exploration architectures. The high payoff for both human and science exploration missions and technology investment from NASA's Space Technology Mission Directorate (STMD) are providing the necessary convergence and impetus for a 30-kilowatt-class SEP mission. Multiple 30-50- kilowatt Solar Electric Propulsion Technology Demonstration Mission (SEP TDM) concepts have been developed based on the maturing electric propulsion and solar array technologies by STMD with recent efforts focusing on an Asteroid Redirect Robotic Mission (ARRM). Xenon is the optimal propellant for the existing state-of-the-art electric propulsion systems considering efficiency, storability, and contamination potential. NASA mission concepts developed and those proposed by contracted efforts for the 30-kilowatt-class demonstration have a range of xenon propellant loads from 100s of kilograms up to 10,000 kilograms. This paper examines the status of the xenon industry worldwide, including historical xenon supply and pricing. The paper will provide updated information on the xenon market relative to previous papers that discussed xenon production relative to NASA mission needs. The paper will discuss the various approaches for acquiring on the order of 10 metric tons of xenon propellant to support potential near-term NASA missions. Finally, the paper will discuss acquisitions strategies for larger NASA missions requiring 100s of metric tons of xenon will be discussed.

Reusable Reentry Satellite (RRS): Propulsion system trade study

Science.gov (United States)

1990-01-01

The purpose of the Reusable Reentry Satellite (RRS) Propulsion System Trade Study described in this summary report was to investigate various propulsion options available for incorporation on the RRS and to select the option best suited for RRS application. The design requirements for the RRS propulsion system were driven by the total impulse requirements necessary to operate within the performance envelope specified in the RRS System Requirements Documents. These requirements were incorporated within the Design Reference Missions (DRM's) identified for use in this and other subsystem trade studies. This study investigated the following propulsion systems: solid rocket, monopropellant, bipropellant (monomethyl hydrazine and nitrogen tetroxide or MMH/NTO), dual-mode bipropellant (hydrazine and nitrogen tetroxide or N2H4/NTO), liquid oxygen and liquid hydrogen (LO2/LH2), and an advanced design propulsion system using SDI-developed components. A liquid monopropellant blowdown propulsion system was found to be best suited for meeting the RRS requirements and is recommended as the baseline system. This system was chosen because it is the simplest of all investigated, has the fewest components, and is the most cost effective. The monopropellant system meets all RRS performance requirements and has the capability to provide a very accurate deorbit burn which minimizes reentry dispersions. In addition, no new hardware qualification is required for a monopropellant system. Although the bipropellant systems offered some weight savings capability for missions requiring large deorbit velocities, the advantage of a lower mass system only applies if the total vehicle design can be reduced to allow a cheaper launch vehicle to be used. At the time of this trade study, the overall RRS weight budget and launch vehicle selection were not being driven by the propulsion system selection. Thus, the added cost and complexity of more advanced systems did not warrant application.

Ablative Laser Propulsion: An Update, Part I

International Nuclear Information System (INIS)

Pakhomov, Andrew V.; Cohen, Timothy; Lin Jun; Thompson, M. Shane; Herren, Kenneth A.

2004-01-01

This paper presents an updated review of studies on Ablative Laser Propulsion conducted by the Laser Propulsion Group (LPG) at the University of Alabama in Huntsville. In particular, we describe the newest results of our experimental study of specific impulses and coupling coefficients achieved by double-pulsed ablation of graphite, aluminum, copper and lead targets

Hybrid Propulsion Demonstration Program 250K Hybrid Motor

Science.gov (United States)

Story, George; Zoladz, Tom; Arves, Joe; Kearney, Darren; Abel, Terry; Park, O.

2003-01-01

The Hybrid Propulsion Demonstration Program (HPDP) program was formed to mature hybrid propulsion technology to a readiness level sufficient to enable commercialization for various space launch applications. The goal of the HPDP was to develop and test a 250,000 pound vacuum thrust hybrid booster in order to demonstrate hybrid propulsion technology and enable manufacturing of large hybrid boosters for current and future space launch vehicles. The HPDP has successfully conducted four tests of the 250,000 pound thrust hybrid rocket motor at NASA's Stennis Space Center. This paper documents the test series.

Test facilities for evaluating nuclear thermal propulsion systems

International Nuclear Information System (INIS)

Beck, D.F.; Allen, G.C.; Shipers, L.R.; Dobranich, D.; Ottinger, C.A.; Harmon, C.D.; Fan, W.C.; Todosow, M.

1992-01-01

Interagency panels evaluating nuclear thermal propulsion (NTP) development options have consistently recognized the need for constructing a major new ground test facility to support fuel element and engine testing. This paper summarizes the requirements, configuration, and baseline performance of some of the major subsystems designed to support a proposed ground test complex for evaluating nuclear thermal propulsion fuel elements and engines being developed for the Space Nuclear Thermal Propulsion (SNTP) program. Some preliminary results of evaluating this facility for use in testing other NTP concepts are also summarized

Energetic Combustion Devices for Aerospace Propulsion and Power

Science.gov (United States)

Litchford, Ron J.

2000-01-01

Chemical reactions have long been the mainstay thermal energy source for aerospace propulsion and power. Although it is widely recognized that the intrinsic energy density limitations of chemical bonds place severe constraints on maximum realizable performance, it will likely be several years before systems based on high energy density nuclear fuels can be placed into routine service. In the mean time, efforts to develop high energy density chemicals and advanced combustion devices which can utilize such energetic fuels may yield worthwhile returns in overall system performance and cost. Current efforts in this vein are being carried out at NASA MSFC under the direction of the author in the areas of pulse detonation engine technology development and light metals combustion devices. Pulse detonation engines are touted as a low cost alternative to gas turbine engines and to conventional rocket engines, but actual performance and cost benefits have yet to be convincingly demonstrated. Light metal fueled engines also offer potential benefits in certain niche applications such as aluminum/CO2 fueled engines for endo-atmospheric Martian propulsion. Light metal fueled MHD generators also present promising opportunities with respect to electric power generation for electromagnetic launch assist. This presentation will discuss the applications potential of these concepts with respect to aero ace propulsion and power and will review the current status of the development efforts.

Electric propulsion reliability: Statistical analysis of on-orbit anomalies and comparative analysis of electric versus chemical propulsion failure rates

Science.gov (United States)

Saleh, Joseph Homer; Geng, Fan; Ku, Michelle; Walker, Mitchell L. R.

2017-10-01

With a few hundred spacecraft launched to date with electric propulsion (EP), it is possible to conduct an epidemiological study of EP's on orbit reliability. The first objective of the present work was to undertake such a study and analyze EP's track record of on orbit anomalies and failures by different covariates. The second objective was to provide a comparative analysis of EP's failure rates with those of chemical propulsion. Satellite operators, manufacturers, and insurers will make reliability- and risk-informed decisions regarding the adoption and promotion of EP on board spacecraft. This work provides evidence-based support for such decisions. After a thorough data collection, 162 EP-equipped satellites launched between January 1997 and December 2015 were included in our dataset for analysis. Several statistical analyses were conducted, at the aggregate level and then with the data stratified by severity of the anomaly, by orbit type, and by EP technology. Mean Time To Anomaly (MTTA) and the distribution of the time to (minor/major) anomaly were investigated, as well as anomaly rates. The important findings in this work include the following: (1) Post-2005, EP's reliability has outperformed that of chemical propulsion; (2) Hall thrusters have robustly outperformed chemical propulsion, and they maintain a small but shrinking reliability advantage over gridded ion engines. Other results were also provided, for example the differentials in MTTA of minor and major anomalies for gridded ion engines and Hall thrusters. It was shown that: (3) Hall thrusters exhibit minor anomalies very early on orbit, which might be indicative of infant anomalies, and thus would benefit from better ground testing and acceptance procedures; (4) Strong evidence exists that EP anomalies (onset and likelihood) and orbit type are dependent, a dependence likely mediated by either the space environment or differences in thrusters duty cycles; (5) Gridded ion thrusters exhibit both

Colliding beam fusion reactor space propulsion system

International Nuclear Information System (INIS)

Wessel, Frank J.; Binderbauer, Michl W.; Rostoker, Norman; Rahman, Hafiz Ur; O'Toole, Joseph

2000-01-01

We describe a space propulsion system based on the Colliding Beam Fusion Reactor (CBFR). The CBFR is a high-beta, field-reversed, magnetic configuration with ion energies in the range of hundreds of keV. Repetitively-pulsed ion beams sustain the plasma distribution and provide current drive. The confinement physics is based on the Vlasov-Maxwell equation, including a Fokker Planck collision operator and all sources and sinks for energy and particle flow. The mean azimuthal velocities and temperatures of the fuel ion species are equal and the plasma current is unneutralized by the electrons. The resulting distribution functions are thermal in a moving frame of reference. The ion gyro-orbit radius is comparable to the dimensions of the confinement system, hence classical transport of the particles and energy is expected and the device is scaleable. We have analyzed the design over a range of 10 6 -10 9 Watts of output power (0.15-150 Newtons thrust) with a specific impulse of, I sp ∼10 6 sec. A 50 MW propulsion system might involve the following parameters: 4-meters diameterx10-meters length, magnetic field ∼7 Tesla, ion beam current ∼10 A, and fuels of either D-He 3 ,P-B 11 ,P-Li 6 ,D-Li 6 , etc

Nuclear rockets: High-performance propulsion for Mars

International Nuclear Information System (INIS)

Watson, C.W.

1994-05-01

A new impetus to manned Mars exploration was introduced by President Bush in his Space Exploration Initiative. This has led, in turn, to a renewed interest in high-thrust nuclear thermal rocket propulsion (NTP). The purpose of this report is to give a brief tutorial introduction to NTP and provide a basic understanding of some of the technical issues in the realization of an operational NTP engine. Fundamental physical principles are outlined from which a variety of qualitative advantages of NTP over chemical propulsion systems derive, and quantitative performance comparisons are presented for illustrative Mars missions. Key technologies are described for a representative solid-core heat-exchanger class of engine, based on the extensive development work in the Rover and NERVA nuclear rocket programs (1955 to 1973). The most driving technology, fuel development, is discussed in some detail for these systems. Essential highlights are presented for the 19 full-scale reactor and engine tests performed in these programs. On the basis of these tests, the practicality of graphite-based nuclear rocket engines was established. Finally, several higher-performance advanced concepts are discussed. These have received considerable attention, but have not, as yet, developed enough credibility to receive large-scale development

Research Activities on Special Propulsion in BUAA

International Nuclear Information System (INIS)

Tang Haibin; Wang Haixing; Liu Chang; Xiang Min; Yao Jie; Liu Yu

2007-01-01

An overview is presented of special propulsion research carried out in Beijing University of Aeronautics and Astronautics of China. The research activities are supported by NSFC (National Natural Science Foundation of China), other governmental agencies and industrial partners, which include experimental, analytical and numerical work related to arcjet thrusters, ion thrusters, plasma sail and other new concept propulsions

The Potential for Ambient Plasma Wave Propulsion

Science.gov (United States)

Gilland, James H.; Williams, George J.

2016-01-01

A truly robust space exploration program will need to make use of in-situ resources as much as possible to make the endeavor affordable. Most space propulsion concepts are saddled with one fundamental burden; the propellant needed to produce momentum. The most advanced propulsion systems currently in use utilize electric and/or magnetic fields to accelerate ionized propellant. However, significant planetary exploration missions in the coming decades, such as the now canceled Jupiter Icy Moons Orbiter, are restricted by propellant mass and propulsion system lifetimes, using even the most optimistic projections of performance. These electric propulsion vehicles are inherently limited in flexibility at their final destination, due to propulsion system wear, propellant requirements, and the relatively low acceleration of the vehicle. A few concepts are able to utilize the environment around them to produce thrust: Solar or magnetic sails and, with certain restrictions, electrodynamic tethers. These concepts focus primarily on using the solar wind or ambient magnetic fields to generate thrust. Technically immature, quasi-propellantless alternatives lack either the sensitivity or the power to provide significant maneuvering. An additional resource to be considered is the ambient plasma and magnetic fields in solar and planetary magnetospheres. These environments, such as those around the Sun or Jupiter, have been shown to host a variety of plasma waves. Plasma wave propulsion takes advantage of an observed astrophysical and terrestrial phenomenon: Alfven waves. These are waves that propagate in the plasma and magnetic fields around and between planets and stars. The generation of Alfven waves in ambient magnetic and plasma fields to generate thrust is proposed as a truly propellantless propulsion system which may enable an entirely new matrix of exploration missions. Alfven waves are well known, transverse electromagnetic waves that propagate in magnetized plasmas at

Hybrid-Electric Aircraft TOGW Development Tool with Empirically-Based Airframe and Physics-Based Hybrid Propulsion System Component Analysis, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Hybrid-Electric distributed propulsion (HEDP) is becoming widely accepted and new tools will be required for future development. This Phase I SBIR proposal creates a...

Aeronautic propulsion systems; Propulseurs aeronautiques

Energy Technology Data Exchange (ETDEWEB)

Lepourry, P; Ciryci, R

1992-12-31

This book is devoted to airplane pilots having a private licence and who would like to take up a professional rank. It comprises 8 chapters dealing with: the different type of propulsion systems, turbojet, turbofan and piston engines; the propeller (characteristics, different types, functioning, protection systems..); the piston engines (4-stroke cycle, power and efficiency, description, characteristics); the gas generator and its limitations (air intake, combustion chamber, turbines, nozzles, fuel systems..); the performances of propulsion systems; the drive, control and instruments; and the use of engines. The last chapter is a self-evaluation questionnaire about the notions developed in the book. (J.S.)

Propulsion of magnetically levitated trains

Energy Technology Data Exchange (ETDEWEB)

Wipf, S L

1976-05-01

A propulsion system for magnetically levitated trains is proposed. A method of periodically energizing magnetic loops on a train moving over a periodically undulating track allows the net repulsive magnetic force to tilt forward or backward for either propulsion or braking. The principle is explained and a specific example discussed. Approximate calculations show feasibility. Problems requiring technical solutions which cannot be considered present state-of-the-art are AC losses at frequencies up to 20 Hz and mechanical fatigue properties at low temperatures. Suitable primary power could be derived from hydrogen-fueled turbines yet to be developed.

Antimatter Propulsion Developed by NASA

Science.gov (United States)

1999-01-01

This Quick Time movie shows possible forms of an antimatter propulsion system being developed by NASA. Antimatter annihilation offers the highest possible physical energy density of any known reaction substance. It is about 10 billion times more powerful than that of chemical energy such as hydrogen and oxygen combustion. Antimatter would be the perfect rocket fuel, but the problem is that the basic component of antimatter, antiprotons, doesn't exist in nature and has to manufactured. The process of antimatter development is ongoing and making some strides, but production of this as a propulsion system is far into the future.

Rocket Scientist for a Day: Investigating Alternatives for Chemical Propulsion

Science.gov (United States)

Angelin, Marcus; Rahm, Martin; Gabrielsson, Erik; Gumaelius, Lena

2012-01-01

This laboratory experiment introduces rocket science from a chemistry perspective. The focus is set on chemical propulsion, including its environmental impact and future development. By combining lecture-based teaching with practical, theoretical, and computational exercises, the students get to evaluate different propellant alternatives. To…

Gravity-assist engine for space propulsion

Science.gov (United States)

Bergstrom, Arne

2014-06-01

As a possible alternative to rockets, the present article describes a new type of engine for space travel, based on the gravity-assist concept for space propulsion. The new engine is to a great extent inspired by the conversion of rotational angular momentum to orbital angular momentum occurring in tidal locking between astronomical bodies. It is also greatly influenced by Minovitch's gravity-assist concept, which has revolutionized modern space technology, and without which the deep-space probes to the outer planets and beyond would not have been possible. Two of the three gravitating bodies in Minovitch's concept are in the gravity-assist engine discussed in this article replaced by an extremely massive ‘springbell' (in principle a spinning dumbbell with a powerful spring) incorporated into the spacecraft itself, and creating a three-body interaction when orbiting around a gravitating body. This makes gravity-assist propulsion possible without having to find suitably aligned astronomical bodies. Detailed numerical simulations are presented, showing how an actual spacecraft can use a ca 10-m diameter springbell engine in order to leave the earth's gravitational field and enter an escape trajectory towards interplanetary destinations.

Application of SDI technology in space propulsion

International Nuclear Information System (INIS)

Klein, A.J.

1992-01-01

Numerous technologies developed by the DOD within the SDI program are now available for adaptation to the requirements of commercial spacecraft; SDI has accordingly organized the Technology Applications Information System data base, which contains nearly 2000 nonproprietary abstracts on SDI technology. Attention is here given to such illustrative systems as hydrogen arcjets, ammonia arcjets, ion engines, SSTO launch vehicles, gel propellants, lateral thrusters, pulsed electrothermal thrusters, laser-powered rockets, and nuclear propulsion

The effects of rear-wheel camber on the kinematics of upper extremity during wheelchair propulsion.

Science.gov (United States)

Tsai, Chung-Ying; Lin, Chien-Ju; Huang, Yueh-Chu; Lin, Po-Chou; Su, Fong-Chin

2012-11-22

The rear-wheel camber, defined as the inclination of the rear wheels, is usually used in wheelchair sports, but it is becoming increasingly employed in daily propulsion. Although the rear-wheel camber can increase stability, it alters physiological performance during propulsion. The purpose of the study is to investigate the effects of rear-wheel cambers on temporal-spatial parameters, joint angles, and propulsion patterns. Twelve inexperienced subjects (22.3±1.6 yr) participated in the study. None had musculoskeletal disorders in their upper extremities. An eight-camera motion capture system was used to collect the three-dimensional trajectory data of markers attached to the wheelchair-user system during propulsion. All participants propelled the same wheelchair, which had an instrumented wheel with cambers of 0°, 9°, and 15°, respectively, at an average velocity of 1 m/s. The results show that the rear-wheel camber significantly affects the average acceleration, maximum end angle, trunk movement, elbow joint movement, wrist joint movement, and propulsion pattern. The effects are especially significant between 0° and 15°. For a 15° camber, the average acceleration and joint peak angles significantly increased (p propulsion patterns and joint range of motion. When choosing a wheelchair with camber adjustment, the increase of joint movements and the base of support should be taken into consideration.

Ship propulsion reactors technology

International Nuclear Information System (INIS)

Fribourg, Ch.

2002-01-01

This paper takes the state of the art on ship propulsion reactors technology. The french research programs with the corresponding technological stakes, the reactors specifications and advantages are detailed. (A.L.B.)

Advanced supersonic propulsion study, phase 4

Science.gov (United States)

Howlett, R. A.

1977-01-01

Installation characteristics for a Variable Stream Control Engine (VSCE) were studied for three advanced supersonic airplane designs. Sensitivity of the VSCE concept to change in technology projections was evaluated in terms of impact on overall installed performance. Based on these sensitivity results, critical technology requirements were reviewed, resulting in the reaffirmation of the following requirements: low-noise nozzle system; a high performance, low emissions duct burner and main burner; hot section technology; variable geometry components; and propulsion integration features, including an integrated electronic control system.

The effect of Reynolds number on the propulsive efficiency of a biomorphic pulsed-jet underwater vehicle

International Nuclear Information System (INIS)

Moslemi, Ali A; Krueger, Paul S

2011-01-01

The effect of Reynolds number on the propulsive efficiency of pulsed-jet propulsion was studied experimentally on a self-propelled, pulsed-jet underwater vehicle, dubbed Robosquid due to the similarity of its propulsion system with squid. Robosquid was tested for jet slug length-to-diameter ratios (L/D) in the range 2-6 and dimensionless frequency (St L ) in the range 0.2-0.6 in a glycerin-water mixture. Digital particle image velocimetry was used for measuring the impulse and energy of jet pulses from the velocity and vorticity fields of the jet flow to calculate the pulsed-jet propulsive efficiency, and compare it with an equivalent steady jet system. Robosquid's Reynolds number (Re) based on average vehicle velocity and vehicle diameter ranged between 37 and 60. The current results for propulsive efficiency were compared to the previously published results in water where Re ranged between 1300 and 2700. The results showed that the average propulsive efficiency decreased by 26% as the average Re decreased from 2000 to 50 while the ratio of pulsed-jet to steady jet efficiency (η P /η P,ss ) increased up to 0.15 (26%) as the Re decreased over the same range and for similar pulsing conditions. The improved η P /η P,ss at lower Re suggests that pulsed-jet propulsion can be used as an efficient propulsion system for millimeter-scale propulsion applications. The Re = 37-60 conditions in the present investigation, showed a reduced dependence of η P and η P /η P,ss on L/D compared to higher Re results. This may be due to the lack of clearly observed vortex ring pinch-off as L/D increased for this Re regime.

The Gasdynamic Mirror Fusion Propulsion System -- Revisited

International Nuclear Information System (INIS)

Kammash, Terry; Tang, Ricky

2005-01-01

Many of the previous studies assessing the capability of the gasdynamic mirror (GDM) fusion propulsion system employed analyses that ignored the 'ambipolar' potential. This electrostatic potential arises as a result of the rapid escape of the electrons due to their small mass. As they escape, they leave behind an excess positive charge which manifests itself in an electric field that slows down the electrons while speeding up the ions until their respective axial diffusions are equalized. The indirect effect on the ions is that their confinement time is reduced relative to that of zero potential, and hence the plasma length must be increased to accommodate that change. But as they emerge from the thruster mirror - which serves as a magnetic nozzle - the ions acquire an added energy equal to that of the potential energy, and that in turn manifests itself in increased specific impulse and thrust. We assess the propulsive performance of the GDM thruster, based on the more rigorous theory, by applying it to a round trip Mars mission employing a continuous burn acceleration/deceleration type of trajectory. We find that the length of the device and travel time decrease with increasing plasma density, while the total vehicle mass reaches a minimum at a plasma density of 3 x 1016 cm-3. At such a density, and an initial DT ion temperature of 10 keV, a travel time of 60 days is found to be achievable at GDM propulsion parameters of about 200,000 seconds of specific impulse and approximately 47 kN of thrust

The Economics of Advanced In-Space Propulsion

Science.gov (United States)

Bangalore, Manju; Dankanich, John

2016-01-01

The cost of access to space is the single biggest driver is commercial space sector. NASA continues to invest in both launch technology and in-space propulsion. Low-cost launch systems combined with advanced in-space propulsion offer the greatest potential market capture. Launch market capture is critical to national security and has a significant impact on domestic space sector revenue. NASA typically focuses on pushing the limits on performance. However, the commercial market is driven by maximum net revenue (profits). In order to maximum the infusion of NASA investments, the impact on net revenue must be known. As demonstrated by Boeing's dual launch, the Falcon 9 combined with all Electric Propulsion (EP) can dramatically shift the launch market from foreign to domestic providers.

Aircraft Electric Propulsion Systems Applied Research at NASA

Science.gov (United States)

Clarke, Sean

2015-01-01

Researchers at NASA are investigating the potential for electric propulsion systems to revolutionize the design of aircraft from the small-scale general aviation sector to commuter and transport-class vehicles. Electric propulsion provides new degrees of design freedom that may enable opportunities for tightly coupled design and optimization of the propulsion system with the aircraft structure and control systems. This could lead to extraordinary reductions in ownership and operating costs, greenhouse gas emissions, and noise annoyance levels. We are building testbeds, high-fidelity aircraft simulations, and the first highly distributed electric inhabited flight test vehicle to begin to explore these opportunities.

Cre/loxP-mediated adenovirus type 5 packaging signal excision demonstrates that core element VI is sufficient for virus packaging

International Nuclear Information System (INIS)

Maeda, Yasushi; Kimura, En; Uchida, Yuji; Nishida, Yasuto; Yamashita, Satoshi; Arima, Toshiyuki; Uchino, Makoto

2003-01-01

Previous analyses have demonstrated that packaging of the adenovirus type 5 (Ad5) genome is dependent on at least seven cis-acting elements, called AI to AVII, which are located in the left-end region of the genome. These elements have different packaging efficiencies, and without AI through AV, viral DNA cannot be packaged. Here we report the identification of the cis-acting Ad5 packaging domain in vivo by using the Cre/loxP system. We found that an adenoviral DNA fragment (nt 192 to nt 358), which includes elements AI to AV, is excised by Cre recombinase and packaged into capsids. Furthermore, this mutant adenovirus replicated so efficiently by repetitive propagation that its purification by CsCI equilibrium gradient was possible. This study clarified that the region from nt 358 to nt 454 on the viral genome is sufficient for packaging. Recently, the helper-dependent adenoviral vector (HDAd) construction system has been developed for the purpose of gene therapy. This system uses a helper virus with two parallel loxP sites flanking the packaging signal. This region is eliminated by Cre-mediated excision, which prevents helper virus packaging. Our data provide useful information regarding factors affecting efficient elimination

Focused library design and synthesis of 2-mercapto benzothiazole linked 1,2,4-oxadiazoles as COX-2/5-LOX inhibitors

Science.gov (United States)

Yatam, Satayanarayana; Gundla, Rambabu; Jadav, Surender Singh; Pedavenkatagari, Narayana reddy; Chimakurthy, Jithendra; Rani B, Namratha; Kedam, Thyagaraju

2018-05-01

Mercapto benzothiazole linked 1,2,4-oxadiazole derivatives were designed (4a-u) as new anti-inflammatory agents using bioisosteric approach and docking studies. The docking results clearly indicated that the compounds 4a-u shown good docking interaction towards COX-2 enzyme. In silico drug-like properties were also calculated for compounds (4a-u) and exhibited significant H-bond acceptor ratio. All compounds were synthesized and biologically evaluated using in vitro COX-1, COX-2 and 5-LOX assays. Compound 4k and 4q (IC50 = 6.8 μM and IC50 = 5.0 μM) found to be potent, selective COX-2 inhibitors and display better anti-inflammatory activity than standard Ibuprofen. Compound 4l and 4e found to be potent inhibitors against 5-LOX (IC50 = 5.1 μM and IC50 = 5.5 μM). The in vivo anti-inflammatory activity studies shown that the compounds 4q and 4k effectively reducing the paw edema volume at 3h and 5h than standard drug Ibuprofen. The DPPH radical scavenging activity provided anti-oxidant activity of compound 4e (IC50 = 25.6 μM) than reference standard Ascorbic acid.

Outer Planet Missions with Electric Propulsion Systems—Part I

Directory of Open Access Journals (Sweden)

Carlos Renato Huaura Solórzano

2010-01-01

Full Text Available For interplanetary missions, efficient electric propulsion systems can be used to increase the mass delivered to the destination. Outer planet exploration has experienced new interest with the launch of the Cassini and New Horizons Missions. At the present, new technologies are studied for better use of electric propulsion systems in missions to the outer planets. This paper presents low-thrust trajectories using the method of the transporting trajectory to Uranus, Neptune, and Pluto. They use nuclear and radio isotopic electric propulsion. These direct transfers have continuous electric propulsion of low power along the entire trajectory. The main goal of the paper is to optimize the transfers, that is, to provide maximum mass to be delivered to the outer planets.

Nuclear propulsion: to go to the moon in 24 hours

International Nuclear Information System (INIS)

Freeman, M.

1999-01-01

Nuclear propulsion is a necessary step to give to man the opportunity of developing activities in space. This technique enables rockets to go farther, more quickly and to transport more load than the classical chemical propulsion. Space travel requires huge quantities of energy. An equivalent quantity of energy can be extracted from 13 tons of liquid hydrogen-oxygen, from 20 g of uranium (fission), from 0.5 g of deuterium (fusion) and from 0.02 g of anti-hydrogen-hydrogen (annihilation). The concept of nuclear thermal rocket (NTR) is based on an embarked nuclear reactor whose purpose is to heat hydrogen to 3000 K temperature. The thrust can be increased by injecting liquid oxygen in the nozzle to react with supersonic hydrogen. (A.C.)

Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study

Directory of Open Access Journals (Sweden)

Hermanova Marketa

2010-05-01

Full Text Available Abstract Background We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2 and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA and inhibitors of lipoxygenases (LOX and cyclooxygenases (COX. This study is a continuation of our previous work confirming the possibility of enhancing ATRA-induced cell differentiation in these cell lines by the application of LOX/COX inhibitors and brings more detailed information concerning the mechanisms of the enhancement of ATRA-induced differentiation of neuroblastoma cells. Methods Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor on cyclooxygenase-2, were used in this study. Expression profiling was performed using Human Cancer Oligo GEArray membranes that cover 440 cancer-related genes. Results Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement. Furthermore, we also found overexpression of some genes in the same cell line (SK-N-BE(2 or SH-SY5Y after combined treatment with both ATRA and CA, or ATRA and CX. Finally, we also detected that gene expression was changed after treatment with the same inhibitor (CA or CX in combination with ATRA in both cell lines. Conclusions Obtained results confirmed our initial hypothesis of the common mechanism of enhancement in ATRA-induced cell differentiation via inhibition of arachidonic acid metabolic pathway.

MOA: Magnetic Field Oscillating Amplified Thruster and its Application for Nuclear Electric and Thermal Propulsion

International Nuclear Information System (INIS)

Frischauf, Norbert; Hettmer, Manfred; Grassauer, Andreas; Bartusch, Tobias; Koudelka, Otto

2006-01-01

More than 60 years after the later Nobel laureate Hannes Alfven had published a letter stating that oscillating magnetic fields can accelerate ionised matter via magneto-hydrodynamic interactions in a wave like fashion, the technical implementation of Alfven waves for propulsive purposes has been proposed, patented and examined for the first time by a group of inventors. The name of the concept, utilising Alfven waves to accelerate ionised matter for propulsive purposes, is MOA - Magnetic field Oscillating Amplified thruster. Alfven waves are generated by making use of two coils, one being permanently powered and serving also as magnetic nozzle, the other one being switched on and off in a cyclic way, deforming the field lines of the overall system. It is this deformation that generates Alfven waves, which are in the next step used to transport and compress the propulsive medium, in theory leading to a propulsion system with a much higher performance than any other electric propulsion system. Based on computer simulations, which were conducted to get a first estimate on the performance of the system, MOA is a highly flexible propulsion system, whose performance parameters might easily be adapted, by changing the mass flow and/or the power level. As such the system is capable to deliver a maximum specific impulse of 13116 s (12.87 mN) at a power level of 11.16 kW, using Xe as propellant, but can also be attuned to provide a thrust of 236.5 mN (2411 s) at 6.15 kW of power. While space propulsion is expected to be the prime application for MOA and is supported by numerous applications such as Solar and/or Nuclear Electric Propulsion or even as an 'afterburner system' for Nuclear Thermal Propulsion, other terrestrial applications can be thought of as well, making the system highly suited for a common space-terrestrial application research and utilisation strategy. (authors)

An analytical optimization method for electric propulsion orbit transfer vehicles

International Nuclear Information System (INIS)

Oleson, S.R.

1993-01-01

Due to electric propulsion's inherent propellant mass savings over chemical propulsion, electric propulsion orbit transfer vehicles (EPOTVs) are a highly efficient mode of orbit transfer. When selecting an electric propulsion device (ion, MPD, or arcjet) and propellant for a particular mission, it is preferable to use quick, analytical system optimization methods instead of time intensive numerical integration methods. It is also of interest to determine each thruster's optimal operating characteristics for a specific mission. Analytical expressions are derived which determine the optimal specific impulse (Isp) for each type of electric thruster to maximize payload fraction for a desired thrusting time. These expressions take into account the variation of thruster efficiency with specific impulse. Verification of the method is made with representative electric propulsion values on a LEO-to-GEO mission. Application of the method to specific missions is discussed

To Mars and beyond, fast! how plasma propulsion will revolutionize space exploration

CERN Document Server

Chang Díaz, Franklin

2017-01-01

As advanced space propulsion moves slowly from science fiction to achievable reality, the Variable Specific Impulse Magnetoplasma Rocket, or VASIMR, is a leading contender for making 'Mars in a month' a possibility. Developed by Ad Astra Rockets, which was founded by astronaut Franklin Chang-Diaz and backed by NASA, its first commercial tests are imminent. VASIMR heats plasma to extreme temperatures using radio waves. Strong magnetic fields then funnel this plasma out the back of the engine, creating thrust. The continuous propulsion may place long, fast interplanetary journeys within reach in the near future. While scientists dream of the possibilities of using fusion or well-controlled matter-antimatter interactions to propel spacecraft fast and far, that goal is still some way over the horizon. VASIMR provides a more attainable propulsion technology that is based on the matter-antimatter concept. The book describes a landmark technology grounded in plasma physics and offering a practical technological solu...

Laddermill-sailing. Ship propulsion by wind energy independent from the wind direction

Energy Technology Data Exchange (ETDEWEB)

Ockels, W. J.

2007-12-15

The use of large kites in ship propulsion has been getting a growing attention because of the urgent need to reduce the CO2 production and thus stop the use of fossil fuels. A novel application of ship propulsion by kites is proposed based on a Laddermill apparatus mounted on a ship. Such an apparatus consist of a winch, an electric motor/generator, a kite system (including launch and retrieval) and controlling electronics. Rather than the traditional sailing by wind force the Laddermill propulsion is achieved by a combination of the production and use of electrical power and the direct pulling force from the kite system. The feasibility of this application is investigated. It is shown that when the overall Laddermill to ship thrust efficiency can be made around 50% the resulting speed of the ship becomes practically independent from the wind direction. Such a capability could thus well change the world's seafaring.

FY2016 Propulsion Materials Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-05-01

The Propulsion Materials Program actively supports the energy security and reduction of greenhouse emissions goals of VTO by investigating and identifying the materials properties that are most essential for continued development of cost-effective, highly efficient, and environmentally friendly next-generation heavy and light-duty powertrains. The technical approaches available to enhance propulsion systems focus on improvements in both vehicle efficiency and fuel substitution, both of which must overcome the performance limitations of the materials currently in use. Propulsion Materials Program activities work with national laboratories, industry experts, and VTO powertrain systems (e.g., Advanced Combustion Engines and Fuels) teams to develop strategies that overcome materials limitations in future powertrain performance. The technical maturity of the portfolio of funded projects ranges from basic science to subsystem prototype validation. Projects within a Propulsion Materials Program activity address materials concerns that directly impact critical technology barriers within each of the above programs, including barriers that impact fuel efficiency, thermal management, emissions reduction, improved reliability, and reduced manufacturing costs. The program engages only the barriers that result from material property limitations and represent fundamental, high-risk materials issues.

Propulsion via flexible flapping in granular media

Science.gov (United States)

Peng, Zhiwei; Ding, Yang; Pietrzyk, Kyle; Elfring, Gwynn; Pak, On Shun

2017-11-01

Biological locomotion in nature is often achieved by the interaction between a flexible body and its surrounding medium. The interaction of a flexible body with granular media is less understood compared with viscous fluids partially due to its complex rheological properties. In this work, we explore the effect of flexibility on granular propulsion by considering a simple mechanical model in which a rigid rod is connected to a torsional spring that is under a displacement actuation using a granular resistive force theory. Through a combined numerical and asymptotic investigation, we characterize the propulsive dynamics of such a flexible flapper in relation to the actuation amplitude and spring stiffness, and we compare these dynamics with those observed in a viscous fluid. In addition, we demonstrate that the maximum possible propulsive force can be obtained in the steady propulsion limit with a finite spring stiffness and large actuation amplitude. These results may apply to the development of synthetic locomotive systems that exploit flexibility to move through complex terrestrial media. Funding for Z.P. and Y.D. was partially provided by NSFC 394 Grant No. 11672029 and NSAF-NSFC Grant No. U1530401.

Nuclear propulsion for the space exploration initiative

International Nuclear Information System (INIS)

Stanley, M.L.

1991-01-01

President Bush's speech of July 20, 1989, outlining a goal to go back to the moon and then Mars initiated the Space Exploration Initiative (SEI). The US Department of Defense (DOD), US Department of Energy (DOE), and NASA have been working together in the planning necessary to initiate a program to develop a nuclear propulsion system. Applications of nuclear technology for in-space transfer of personnel and cargo between Earth orbit and lunar or Martian orbit are being considered as alternatives to chemical propulsion systems. Mission and system concept studies conducted over the past 30 yr have consistently indicated that use of nuclear technology can substantially reduce in-space propellant requirements. A variety of nuclear technology options are currently being studied, including nuclear thermal rockets, nuclear electrical propulsion systems, and hybrid nuclear thermal rockets/nuclear electric propulsion concepts. Concept performance in terms of thrust, weight, power, and efficiency are dependent, and appropriate concept application is mission dependent (i.e., lunar, Mars, cargo, personnel, trajectory, transit time, payload). A comprehensive evaluation of mission application, technology performance capability and maturity, technology development programmatics, and safety characteristics is required to optimize both technology and mission selection to support the Presidential initiative

Challenges of future aircraft propulsion: A review of distributed propulsion technology and its potential application for the all electric commercial aircraft

Science.gov (United States)

Gohardani, Amir S.; Doulgeris, Georgios; Singh, Riti

2011-07-01

This paper highlights the role of distributed propulsion technology for future commercial aircraft. After an initial historical perspective on the conceptual aspects of distributed propulsion technology and a glimpse at numerous aircraft that have taken distributed propulsion technology to flight, the focal point of the review is shifted towards a potential role this technology may entail for future commercial aircraft. Technological limitations and challenges of this specific technology are also considered in combination with an all electric aircraft concept, as means of predicting the challenges associated with the design process of a next generation commercial aircraft.

Turboprop Propulsion Mechanic.

Science.gov (United States)

Chanute AFB Technical Training Center, IL.

This instructional package consists of a plan of instruction, glossary, and student handouts and exercises for use in training Air Force personnel to become turboprop propulsion mechanics. Addressed in the individual lessons of the course are the following: common hand tools, hardware, measuring devices, and safety wiring; aircraft and engine…

A High-power Electric Propulsion Test Platform in Space

Science.gov (United States)

Petro, Andrew J.; Reed, Brian; Chavers, D. Greg; Sarmiento, Charles; Cenci, Susanna; Lemmons, Neil

2005-01-01

This paper will describe the results of the preliminary phase of a NASA design study for a facility to test high-power electric propulsion systems in space. The results of this design study are intended to provide a firm foundation for subsequent detailed design and development activities leading to the deployment of a valuable space facility. The NASA Exploration Systems Mission Directorate is sponsoring this design project. A team from the NASA Johnson Space Center, Glenn Research Center, the Marshall Space Flight Center and the International Space Station Program Office is conducting the project. The test facility is intended for a broad range of users including government, industry and universities. International participation is encouraged. The objectives for human and robotic exploration of space can be accomplished affordably, safely and effectively with high-power electric propulsion systems. But, as thruster power levels rise to the hundreds of kilowatts and up to megawatts, their testing will pose stringent and expensive demands on existing Earth-based vacuum facilities. These considerations and the human access to near-Earth space provided by the International Space Station (ISS) have led to a renewed interest in space testing. The ISS could provide an excellent platform for a space-based test facility with the continuous vacuum conditions of the natural space environment and no chamber walls to modify the open boundary conditions of the propulsion system exhaust. The test platform could take advantage of the continuous vacuum conditions of the natural space environment. Space testing would provide open boundary conditions without walls, micro-gravity and a realistic thermal environment. Testing on the ISS would allow for direct observation of the test unit, exhaust plume and space-plasma interactions. When necessary, intervention by on-board personnel and post-test inspection would be possible. The ISS can provide electrical power, a location for

Accelerometer output and its association with energy expenditure during manual wheelchair propulsion.

Science.gov (United States)

Learmonth, Y C; Kinnett-Hopkins, D; Rice, I M; Dysterheft, J L; Motl, R W

2016-02-01

This is an experimental design. This study examined the association between rates of energy expenditure (that is, oxygen consumption (VO2)) and accelerometer counts (that is, vector magnitude (VM)) across a range of speeds during manual wheelchair propulsion on a motor-driven treadmill. Such an association allows for the generation of cutoff points for quantifying the time spent in moderate-to-vigorous physical activity (MVPA) during manual wheelchair propulsion. The study was conducted in the University Laboratory. Twenty-four manual wheelchair users completed a 6-min period of seated rest and three 6-min periods of manual wheelchair propulsion on a motor-driven wheelchair treadmill. The 6-min periods of wheelchair propulsion corresponded with three treadmill speeds (1.5, 3.0 and 4.5 mph) that elicited a range of physical activity intensities. Participants wore a portable metabolic unit and accelerometers on both wrists. Primary outcome measures included steady-state VO2 and VM, and the strength of association between VO2 and VM was based on the multiple correlation and squared multiple correlation coefficients from linear regression analyses. Strong linear associations were established between VO2 and VM for the left (R=0.93±0.44; R2=0.87±0.19), right (R=0.95±0.37; R2=0.90±0.14) and combined (R=0.94±0.38; R2=0.88±0.15) accelerometers. The linear relationship between VO2 and VM for the left, right and combined wrists yielded cutoff points for MVPA of 3659 ±1302, 3630±1403 and 3644±1339 counts min(-1), respectively. We provide cutoff points based on the linear association between energy expenditure and accelerometer counts for estimating time spent in MVPA during manual wheelchair propulsion using wrist-worn accelerometry. The similarity across wrist location permits flexibility in selecting a location for wrist accelerometry placement.

NASA's Launch Propulsion Systems Technology Roadmap

Science.gov (United States)

McConnaughey, Paul K.; Femminineo, Mark G.; Koelfgen, Syri J.; Lepsch, Roger A; Ryan, Richard M.; Taylor, Steven A.

2012-01-01

Safe, reliable, and affordable access to low-Earth (LEO) orbit is necessary for all of the United States (US) space endeavors. In 2010, NASA s Office of the Chief Technologist commissioned 14 teams to develop technology roadmaps that could be used to guide the Agency s and US technology investment decisions for the next few decades. The Launch Propulsion Systems Technology Area (LPSTA) team was tasked to address the propulsion technology challenges for access to LEO. The developed LPSTA roadmap addresses technologies that enhance existing solid or liquid propulsion technologies and their related ancillary systems or significantly advance the technology readiness level (TRL) of less mature systems like airbreathing, unconventional, and other launch technologies. In developing this roadmap, the LPSTA team consulted previous NASA, military, and industry studies as well as subject matter experts to develop their assessment of this field, which has fundamental technological and strategic impacts for US space capabilities.

Ultra-high temperature direct propulsion

International Nuclear Information System (INIS)

Araj, K.J.; Slovik, G.; Powell, J.R.; Ludewig, H.

1987-01-01

Potential advantages of ultra-high exhaust temperature (3000 K - 4000 K) direct propulsion nuclear rockets are explored. Modifications to the Particle Bed Reactor (PBR) to achieve these temperatures are described. Benefits of ultra-high temperature propulsion are discussed for two missions - orbit transfer (ΔV = 5546 m/s) and interplanetary exploration (ΔV = 20000 m/s). For such missions ultra-high temperatures appear to be worth the additional complexity. Thrust levels are reduced substantially for a given power level, due to the higher enthalpy caused by partial disassociation of the hydrogen propellant. Though technically challenging, it appears potentially feasible to achieve such ultra high temperatures using the PBR

Hybrid Propulsion Technology for Robotic Science Missions, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — C3 Propulsion's Hybrid Propulsion Technology will be applied to a NASA selected Sample Return Mission. Phase I will demonstrate Proof-of-Principle and Phase II will...

An Intelligent Propulsion Control Architecture to Enable More Autonomous Vehicle Operation

Science.gov (United States)

Litt, Jonathan S.; Sowers, T. Shane; Simon, Donald L.; Owen, A. Karl; Rinehart, Aidan W.; Chicatelli, Amy K.; Acheson, Michael J.; Hueschen, Richard M.; Spiers, Christopher W.

2018-01-01

This paper describes an intelligent propulsion control architecture that coordinates with the flight control to reduce the amount of pilot intervention required to operate the vehicle. Objectives of the architecture include the ability to: automatically recognize the aircraft operating state and flight phase; configure engine control to optimize performance with knowledge of engine condition and capability; enhance aircraft performance by coordinating propulsion control with flight control; and recognize off-nominal propulsion situations and to respond to them autonomously. The hierarchical intelligent propulsion system control can be decomposed into a propulsion system level and an individual engine level. The architecture is designed to be flexible to accommodate evolving requirements, adapt to technology improvements, and maintain safety.

Institute for Computational Mechanics in Propulsion (ICOMP)

Science.gov (United States)

Keith, Theo G., Jr. (Editor); Balog, Karen (Editor); Povinelli, Louis A. (Editor)

2001-01-01

The Institute for Computational Mechanics in Propulsion (ICOMP) was formed to develop techniques to improve problem-solving capabilities in all aspects of computational mechanics related to propulsion. ICOMP is operated by the Ohio Aerospace Institute (OAI) and funded via numerous cooperative agreements by the NASA Glenn Research Center in Cleveland, Ohio. This report describes the activities at ICOMP during 1999, the Institute's fourteenth year of operation.

Individual muscle contributions to push and recovery subtasks during wheelchair propulsion.

Science.gov (United States)

Rankin, Jeffery W; Richter, W Mark; Neptune, Richard R

2011-04-29

Manual wheelchair propulsion places considerable physical demand on the upper extremity and is one of the primary activities associated with the high prevalence of upper extremity overuse injuries and pain among wheelchair users. As a result, recent effort has focused on determining how various propulsion techniques influence upper extremity demand during wheelchair propulsion. However, an important prerequisite for identifying the relationships between propulsion techniques and upper extremity demand is to understand how individual muscles contribute to the mechanical energetics of wheelchair propulsion. The purpose of this study was to use a forward dynamics simulation of wheelchair propulsion to quantify how individual muscles deliver, absorb and/or transfer mechanical power during propulsion. The analysis showed that muscles contribute to either push (i.e., deliver mechanical power to the handrim) or recovery (i.e., reposition the arm) subtasks, with the shoulder flexors being the primary contributors to the push and the shoulder extensors being the primary contributors to the recovery. In addition, significant activity from the shoulder muscles was required during the transition between push and recovery, which resulted in increased co-contraction and upper extremity demand. Thus, strengthening the shoulder flexors and promoting propulsion techniques that improve transition mechanics have much potential to reduce upper extremity demand and improve rehabilitation outcomes. Copyright © 2011 Elsevier Ltd. All rights reserved.

In-Space Demonstration of High Performance Green Propulsion and its Impact on Small Satellites

OpenAIRE

Anflo, Kjell; Crowe, Ben

2011-01-01

This paper summarizes the pre-launch activities and the results from the in-space demonstration of a novel propulsion system on the PRISMA main satellite, using a “Green” monopropellant. This propellant is a storable ADN-based monopropellant blend (i.e. LMP-103S). The basic mission for the High Performance Green Propulsion System (HPGP) has been successfully completed and all primary objectives of TRL 7 have been met. The HPGP technology is now flight proven and ready for implementation on fu...

Experimental study and numerical simulation of the propulsion of microbeads by femtosecond laser filament

International Nuclear Information System (INIS)

Zhang Nan; Liu Weiwei; Xu Zhijun; Wang Mingwei; Zhu Xiaonong

2008-01-01

The light filament formed by intense femtosecond laser pulses in air can be used to generate the effective impulse to propel a micro glass bead. In this report, through both experimental studies and the corresponding numerical simulations that involve the dynamics of the nonlinear propagation of light and the laser ablation mechanism, we confirm that this propulsion scheme is based on the laser ablation of the target material. The fundamental characteristics of laser propulsion using a single ultrafast laser filament is also revealed

Experimental evaluation of hybrid propulsion rocket engine operating with paraffin fuel grain and gaseous oxygen

OpenAIRE

Genivaldo Pimenta dos Santos

2014-01-01

In the last decade the hybrid propulsion has been considering as a viable alternative of chemical energy conversion stored in propellants into kinetic energy. This energy is applied in propulsive systems of manned platforms, maneuvering procedures and even in the repositioning process of micro satellites. It presents attractive features and good balance between performance and environmental impact. Paraffin based grains are the hybrid solid fuels appointed as polymeric fuel substitute. The li...

Network Flow Simulation of Fluid Transients in Rocket Propulsion Systems

Science.gov (United States)

Bandyopadhyay, Alak; Hamill, Brian; Ramachandran, Narayanan; Majumdar, Alok

2011-01-01

Fluid transients, also known as water hammer, can have a significant impact on the design and operation of both spacecraft and launch vehicle propulsion systems. These transients often occur at system activation and shutdown. The pressure rise due to sudden opening and closing of valves of propulsion feed lines can cause serious damage during activation and shutdown of propulsion systems. During activation (valve opening) and shutdown (valve closing), pressure surges must be predicted accurately to ensure structural integrity of the propulsion system fluid network. In the current work, a network flow simulation software (Generalized Fluid System Simulation Program) based on Finite Volume Method has been used to predict the pressure surges in the feed line due to both valve closing and valve opening using two separate geometrical configurations. The valve opening pressure surge results are compared with experimental data available in the literature and the numerical results compared very well within reasonable accuracy (< 5%) for a wide range of inlet-to-initial pressure ratios. A Fast Fourier Transform is preformed on the pressure oscillations to predict the various modal frequencies of the pressure wave. The shutdown problem, i.e. valve closing problem, the simulation results are compared with the results of Method of Characteristics. Most rocket engines experience a longitudinal acceleration, known as "pogo" during the later stage of engine burn. In the shutdown example problem, an accumulator has been used in the feed system to demonstrate the "pogo" mitigation effects in the feed system of propellant. The simulation results using GFSSP compared very well with the results of Method of Characteristics.

Integrated propulsion for near-Earth space missions. Volume 1: Executive summary

Science.gov (United States)

Dailey, C. L.; Meissinger, H. F.; Lovberg, R. H.; Zafran, S.

1981-01-01

Tradeoffs between electric propulsion system mass ratio and transfer time from LEO to GEO were conducted parametrically for various thruster efficiency, specific impulse, and other propulsion parameters. A computer model was developed for performing orbit transfer calculations which included the effects of aerodynamic drag, radiation degradation, and occultation. The tradeoff results showed that thruster technology areas for integrated propulsion should be directed towards improving primary thruster efficiency in the range from 1500 to 2500 seconds, and be continued towards reducing specific mass. Comparison of auxiliary propulsion systems showed large total propellant mass savings with integrated electric auxiliary propulsion. Stationkeeping is the most demanding on orbit propulsion requirement. At area densities above 0.5 sq m/kg, East-West stationkeeping requirements from solar pressure exceed North-South stationkeeping requirements from gravitational forces. A solar array pointing strategy was developed to minimize the effects of atmospheric drag at low altitude, enabling electric propulsion to initiate orbit transfer at Shuttle's maximum cargo carrying altitude. Gravity gradient torques are used during ascent to sustain the spacecraft roll motion required for optimum solar array illumination. A near optimum cover glass thickness of 6 mils was established for LEO to GEO transfer.

A Computational Method for Determining the Equilibrium Composition and Product Temperature in a LH2/LOX Combustor

Science.gov (United States)

Sozen, Mehmet

2003-01-01

In what follows, the model used for combustion of liquid hydrogen (LH2) with liquid oxygen (LOX) using chemical equilibrium assumption, and the novel computational method developed for determining the equilibrium composition and temperature of the combustion products by application of the first and second laws of thermodynamics will be described. The modular FORTRAN code developed as a subroutine that can be incorporated into any flow network code with little effort has been successfully implemented in GFSSP as the preliminary runs indicate. The code provides capability of modeling the heat transfer rate to the coolants for parametric analysis in system design.

Recent advances in nuclear powered electric propulsion for space exploration

International Nuclear Information System (INIS)

Cassady, R. Joseph; Frisbee, Robert H.; Gilland, James H.; Houts, Michael G.; LaPointe, Michael R.; Maresse-Reading, Colleen M.; Oleson, Steven R.; Polk, James E.; Russell, Derrek; Sengupta, Anita

2008-01-01

Nuclear and radioisotope powered electric thrusters are being developed as primary in space propulsion systems for potential future robotic and piloted space missions. Possible applications for high-power nuclear electric propulsion include orbit raising and maneuvering of large space platforms, lunar and Mars cargo transport, asteroid rendezvous and sample return, and robotic and piloted planetary missions, while lower power radioisotope electric propulsion could significantly enhance or enable some future robotic deep space science missions. This paper provides an overview of recent US high-power electric thruster research programs, describing the operating principles, challenges, and status of each technology. Mission analysis is presented that compares the benefits and performance of each thruster type for high priority NASA missions. The status of space nuclear power systems for high-power electric propulsion is presented. The paper concludes with a discussion of power and thruster development strategies for future radioisotope electric propulsion systems