‘Access to Justice’ and the Development of the Van Gend En Loos Doctrine: The Role of Courts and of the Individual in EU Law

Directory of Open Access Journals (Sweden)

Daminova Nasiya

2017-12-01

Full Text Available The ‘access to justice’ within the meaning of the Treaty of Lisbon and the pertinent CJEU jurisprudence is primarily seen as access to the EU judicial system, i.e. to the EU Member States’ national courts applying the EU Law or/and the CJEU. The concept of ‘access to justice’ is therefore developing such premises of the Van Gend en Loos judgment as direct effect, vigilance of the EU individual, and the symbiotic relationship between the CJEU and national courts via the preliminary reference procedure. This work aims to explore the development of two basic ideas of Van Gend en Loos, i.e. granting directly enforceable EU rights to individuals and authorizing national courts to protect those rights, in light of the ‘access to justice’ concept within the meaning of the Lisbon Treaty – considering their importance for the realization of EU individuals’ substantive rights and uncertainty surrounding this issue. The paper develops a critique of the theory of justice in EU Law, analyzing if and how the Van Gend en Loos premises influenced the role of individuals making an attempt to claim their EU rights and the role of the EU courts responsible for the enforcement of ‘access to justice’ in the European Union. The claim of this paper is that the new concept of ‘access to justice’ brought by the Lisbon Treaty may be seen as the further development of the Van Gend ‘federalizing effect’ for greater integration through law and an enhanced protection of the individual within the EU multilevel system of Human Rights protection.

Collaboration between the CERN Apprenticeship Service and the Geneva industrial organization, Union Industrielle Genevoise (UIG)

CERN Multimedia

Damien Gillieron

1999-01-01

De gauche a droite: C. Monney, laureat; W. Blair, chef des Services Educatifs; Y. Zaugg, President de l'UIG; A. Romanens, laureat; R. Gay, responsable des apprentissages techniques et P. Lathuiliere, delegue pour la formation de l'UIG

Proceedings No. 41. Audition of M. Francois Loos, Delegate Minister of Industry, about the law project relative to the management of radioactive materials and wastes

International Nuclear Information System (INIS)

2006-03-01

The project of law about the management of radioactive materials and wastes is the logical continuation of the law no 91-1381 from December 30, 1991 relative to the researches on radioactive waste management. At the occasion of the presentation of this law project at the board of ministers, F. Loos, the French minister of industry, presented this project the same day also at the house of commons. This document is the proceedings of the audition of F. Loos. It comprises a brief recall of the researches carried out so far and a presentation of the 3 main points of the project of law: reprocessing of spent fuels and recycling in reactors, interim surface storage of non-recyclable wastes, and underground reversible disposal of ultimate wastes. One aspect of the project concerns the scheduling of future research works according to the 3 ways defined in the 1991 law: storage, disposal and transmutation. This presentation is followed by questions from the deputies about some particular points of the project like the safety aspects, the selection of storage sites, the acceptance and information of the public, the financial aspects etc. (J.S.)

In searching for the rots of minimalism in architecture: Formal silence of Adolf Loos

Directory of Open Access Journals (Sweden)

Vasilski Dragana

2011-01-01

Full Text Available Architectural examples of minimalism, combined with strict forms of modern movements, and the possibilities offered by new materials and technologies, contributing to the triumph of aesthetics that has become a symbol of our times. Minimalism in architecture, as the most original contribution to the idea of simplicity in architecture today has its roots in different areas as well as creation of prominent individuals - copyright strong individualities that do not tolerate any kind of categorization. One such author is certainly Adolf Loos. His theoretical ideas regarding decorations were sensational, because while the modernists had a dilemma about where and how to place ornaments, Los was adamant: his drastic solution predicted the complete elimination of ornament. In our time, minimalist architecture brings the ease of Adolf Loosa, whose design is rejected historicism and its parasites, decoration, to the pronounced rationalism. It is possible to follow the guiding principle of his 'formal silence' by Carl Andre to Herzog i de Meuron, as well as over the Mediterranean vernacular architecture to Alberto Campo Baeza and Alvaro Siza.

Tsetse elimination: its interest and feasibility in the historical sleeping sickness focus of Loos islands, Guinea

Directory of Open Access Journals (Sweden)

Kagbadouno M.

2009-03-01

Full Text Available Guinea is the West African country which is currently the most prevalent for sleeping sickness. The littoral area is the region where most of the recent sleeping sickness cases have been described, especially the mangrove sleeping sickness foci of Dubreka and Boffa where Glossina palpalis gambiensis is the vector. Loos islands constitute a small archipelago 5 km apart from the capital, Conakry. Medical, animal, and entomological surveys were implemented in these islands in Oct-Nov 2006. No pathogenic trypanosomes were found in these surveys. The locally very high tsetse densities (up to more than 100 tsetse/trap/day linked to pig rearing, constitute a high potential risk for humans (taking into account populations movements with neighboring active sleeping sickness foci of the Guinea littoral, and the history of sleeping sickness on these islands, and for the economically important pig rearing, as well as a danger for tourism. This situation, associated to the possibility of elimination of these tsetse populations due to low possibility of reinvasion, led the National Control Program to launch a tsetse elimination project following an “area wide” strategy for the first time in West Africa, which participates in the global objective of the PATTEC (Pan African Tsetse and Trypanosomosis Eradication Campaign.

From Raja to Prime Minister Entre rajah et premier ministre. Les étrangers et l’exploitation économique à Bornéo et dans le Pacifique au xixe siècle

Directory of Open Access Journals (Sweden)

Kees van Dijk

2013-03-01

Full Text Available Some twenty years after the Sultan of Brunei had bestowed upon the Englishman James Brooke the title of Rajah of Sarawak, giving him extensive authorities over a large tract of land, an American, Joseph William Torrey, United States consul in Brunei, gained the right to call himself Rajah of Marudu and Ambong. Though Torrey’s efforts failed to establish a profitable business in Sabah, they formed the root of the British North Borneo Company. Torrey probably was one of the last of his kind. Elsewhere in the Pacific, European and American residents and adventurers did not bother much about native titles, expanding their hold over land and its inhabitants by economic and political manipulation. In Hawaii and Samoa political reform and becoming cabinet minister or prime minister of a still independent island state served their purposes better.Quelque vingt ans après que le sultan de Brunei eut accordé à l’Anglais James Brooke le titre de rajah de Sarawak, qui lui donnait d’importants pouvoirs sur une vaste région, un Américain, Joseph William Torrey, consul des Etats-Unis à Brunei, obtint le titre de rajah de Marudu et Ambong. Les efforts de Torrey, échouant à établir une affaire profitable à Sabah, constituèrent néanmoins les bases de la British North Borneo Company. Torrey fut sans doute l’un des derniers de ce type d’aventuriers. Ailleurs dans le Pacifique, des résidents et des aventuriers européens et américains, par des manœuvres économiques et politiques, consolidèrent leur contrôle sur les territoires et leurs populations, sans trop se soucier d’obtenir des titres locaux. A Hawaii et à Samoa, il leur fut plus utile d’entreprendre des réformes politiques et de se pourvoir d’un poste de ministre ou de premier ministre d’un Etat insulaire encore indépendant.

Non-invasive prenatal diagnosis of monogenic disorders: an optimized protocol using MEMO qPCR with miniSTR as internal control.

Science.gov (United States)

Guissart, Claire; Debant, Vanessa; Desgeorges, Marie; Bareil, Corinne; Raynal, Caroline; Toga, Caroline; Pritchard, Victoria; Koenig, Michel; Claustres, Mireille; Vincent, Marie-Claire

2015-02-01

Analysis of circulating cell-free fetal DNA (cffDNA) in maternal plasma is very promising for early diagnosis of monogenic diseases. However, this approach is not yet available for routine use and remains technically challenging because of the low concentration of cffDNA, which is swamped by the overwhelming maternal DNA. To make clinical applications more readily accessible, we propose a new approach based on mutant enrichment with 3'-modified oligonucleotides (MEMO) PCR along with real-time PCR to selectively amplify from the maternal blood the paternally inherited fetal allele that is not present in the maternal genome. The first proof of concept of this strategy was displayed for cystic fibrosis by the accuracy of our detection of the p.Gly542* mutation used as the initial developmental model. Subsequently, a retrospective study of plasmas originating from two pregnant women carrying a fetus with private mutation confirmed the effectiveness of our method. We confirmed the presence of cffDNA in the studied samples by the identification of a tri-allelic DNA profile using a miniSTR kit. This new non-invasive prenatal diagnosis test offers numerous advantages over current methods: it is simple, cost effective, time efficient and does not require complex equipment or bioinformatics settings. Moreover, our assays for different private mutations demonstrate the viability of this approach in clinical settings for monogenic disorders.

Presentation of the policy bill of program on the radioactive materials and wastes management by Francois Loos, Ministry delegate to the Industry, National Assembly

International Nuclear Information System (INIS)

2006-04-01

This document provides the text of the presentation of Francois Loos. The bill institutes a national radioactive materials and waste management plan and defines a programme and calendar for research and work leading to implementation of this plan, which will comprise three major points: with a view to looking to reduce the quantity of waste, spent nuclear fuels taken from the nuclear power plants will be reprocessed for recycling in the plants; waste which cannot be recycled will be packaged in a robust matrix and then temporarily stored on the surface; after interim storage, waste which cannot be finally disposed of in a surface facility, will be placed in a deep geological reversible repository. In order to monitor each step in this plan, the bill strengthens independent assessment of research and involves greater information of the public. With regard to financing, the bill clarifies the fact that economic development of the departments concerned by research into disposal options and the research itself will be financed by additional taxes on the operators of nuclear installations. (A.L.B.)

Policy bill of program on the radioactive materials and wastes management. Press conference. Intervention of Francois Loos, Ministry delegate to the Industry

International Nuclear Information System (INIS)

2006-01-01

This document provides the presentation of Francois Loos concerning the policy bill on the program of radioactive materials and wastes. Three axis of researches are decided: the separation and transmutation, the deep underground disposal and long dated storage and conditioning processes. The bill institutes a national radioactive materials and waste management plan and defines a programme and calendar for research and work leading to implementation of this plan, which will comprise three major points: with a view to looking to reduce the quantity of waste, spent nuclear fuels taken from the nuclear power plants will be reprocessed for recycling in the plants; waste which cannot be recycled will be packaged in a robust matrix and then temporarily stored on the surface; after interim storage, waste which cannot be finally disposed of in a surface facility, will be placed in a deep geological reversible repository. In order to monitor each step in this plan, the bill strengthens independent assessment of research and involves greater information of the public. With regard to financing, the bill clarifies the fact that economic development of the departments concerned by research into disposal options and the research itself will be financed by additional taxes on the operators of nuclear installations. (A.L.B.)

Talk of Francois Loos, delegate minister of industry, at the Meuse prefecture (Bar-le-Duc). Visit of the underground laboratory of research on the geologic disposal of radioactive wastes, Bure (Meuse); Intervention de Francois Loos, ministre delegue a l'Industrie, a la Prefecture de la Meuse (Bar-le-Duc). Visite du laboratoire souterrain de recherche sur le stockage geologique des dechets radioactifs, Bure (Meuse)

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-07-01

In this talk, the French minister of industry recalls, first, the context of the management of radioactive wastes and the research programs launched in the framework of the 'Bataille' law from December 30, 1991. Then, he stresses on the importance of the work carried out so far in the three ways of research on radioactive wastes: separation/transmutation, deep underground disposal and long duration surface storage. He introduces the government will of organizing a public debate about the management of radioactive wastes before the preparation of the law project for the implementation of the technological and scientifical choices (the 'road-map') of France in the domain of radioactive wastes management. He stresses also on the importance of the financing warranties of this management and of the public information in this domain. He concludes on the economical support of the government in consideration of the regions that have accepted or would accept the setting up of waste management research laboratories and industrial facilities. (J.S.)

Loosenin, a novel protein with cellulose-disrupting activity from Bjerkandera adusta.

Science.gov (United States)

Quiroz-Castañeda, Rosa E; Martínez-Anaya, Claudia; Cuervo-Soto, Laura I; Segovia, Lorenzo; Folch-Mallol, Jorge L

2011-02-11

Expansins and expansin-like proteins loosen cellulose microfibrils, possibly through the rupture of intramolecular hydrogen bonds. Together with the use of lignocellulolytic enzymes, these proteins are potential molecular tools to treat plant biomass to improve saccharification yields. Here we describe a new type of expansin-related fungal protein that we have called loosenin. Its corresponding gene, loos1, from the basidiomycete Bjerkandera adusta, was cloned and heterologously expressed in Saccharomyces cerevisiae. LOOS1 is distantly related to plant expansins through the shared presence of a DPBB domain, however domain II found in plant expansins is absent. LOOS1 binds tightly to cellulose and chitin, and we demonstrate that cotton fibers become susceptible to the action of a commercial cellulase following treatment with LOOS1. Natural fibers of Agave tequilana also become susceptible to hydrolysis by cellulases after loosenin treatment. LOOS1 is a new type of protein with disrupting activity on cellulose. LOOS1 binds polysaccharides, and given its enhancing properties on the action of hydrolytic enzymes, LOOS1 represents a potential additive in the production of fermentable sugars from lignocellulose.

Ludwig Wittgenstein

DEFF Research Database (Denmark)

Munch, Anders V.

2006-01-01

Filosoffen Wittgenstein var involveret i et byggeri sammen med arkitekten Paul Engelmann, elev af Adolf Loos. De filosofiske overvejelser om begrebet livsform kan belyse ideerne om den moderne arkitektur hos Loos, mens Loos' stilbegreb omvendt kan belyse sprogfilosofien hos Wittgenstein....

Loosenin, a novel protein with cellulose-disrupting activity from Bjerkandera adusta

Directory of Open Access Journals (Sweden)

Segovia Lorenzo

2011-02-01

Full Text Available Abstract Background Expansins and expansin-like proteins loosen cellulose microfibrils, possibly through the rupture of intramolecular hydrogen bonds. Together with the use of lignocellulolytic enzymes, these proteins are potential molecular tools to treat plant biomass to improve saccharification yields. Results Here we describe a new type of expansin-related fungal protein that we have called loosenin. Its corresponding gene, loos1, from the basidiomycete Bjerkandera adusta, was cloned and heterologously expressed in Saccharomyces cerevisiae. LOOS1 is distantly related to plant expansins through the shared presence of a DPBB domain, however domain II found in plant expansins is absent. LOOS1 binds tightly to cellulose and chitin, and we demonstrate that cotton fibers become susceptible to the action of a commercial cellulase following treatment with LOOS1. Natural fibers of Agave tequilana also become susceptible to hydrolysis by cellulases after loosenin treatment. Conclusions LOOS1 is a new type of protein with disrupting activity on cellulose. LOOS1 binds polysaccharides, and given its enhancing properties on the action of hydrolytic enzymes, LOOS1 represents a potential additive in the production of fermentable sugars from lignocellulose.

Uue kunsti tegijad pakuvad head maali / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2006-01-01

Pärnuga seotud või Pärnust pärit kunstnike uuem looming näitusel "Looja, loo lugu, loo lugu, looja, loo..." Pärnu Uue Kunsti Muuseumis. Osalevad Toomas Kuusing, Siram, Bruno Sõmeri, Anonymous Boh, Mark Soosaar, Jaak Visnap, Mila Balti, Kadri Alesmaa, Bille Neeve. Kuraator Andrus Joonas

Session du Conseil du CERN : le ministre britannique, Robert Jackson, souligne l'intérêt de on pays pour l'avenir du CERN : décisions du Conseil pour la mise en oeuvre des recommandations du Comité d'évaluation du CERN: départ anticipé pour 200 membres au moins du personnel - mise à jour de la méthode de calcule pour les contributions des Etats Membres au budget

CERN Multimedia

CERN Press Office. Geneva

1988-01-01

Session du Conseil du CERN : le ministre britannique, Robert Jackson, souligne l'intérêt de on pays pour l'avenir du CERN : décisions du Conseil pour la mise en oeuvre des recommandations du Comité d'évaluation du CERN: départ anticipé pour 200 membres au moins du personnel - mise à jour de la méthode de calcule pour les contributions des Etats Membres au budget

The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

Science.gov (United States)

Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

2010-09-01

We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

A comparison of resampling schemes for estimating model observer performance with small ensembles

Science.gov (United States)

Elshahaby, Fatma E. A.; Jha, Abhinav K.; Ghaly, Michael; Frey, Eric C.

2017-09-01

In objective assessment of image quality, an ensemble of images is used to compute the 1st and 2nd order statistics of the data. Often, only a finite number of images is available, leading to the issue of statistical variability in numerical observer performance. Resampling-based strategies can help overcome this issue. In this paper, we compared different combinations of resampling schemes (the leave-one-out (LOO) and the half-train/half-test (HT/HT)) and model observers (the conventional channelized Hotelling observer (CHO), channelized linear discriminant (CLD) and channelized quadratic discriminant). Observer performance was quantified by the area under the ROC curve (AUC). For a binary classification task and for each observer, the AUC value for an ensemble size of 2000 samples per class served as a gold standard for that observer. Results indicated that each observer yielded a different performance depending on the ensemble size and the resampling scheme. For a small ensemble size, the combination [CHO, HT/HT] had more accurate rankings than the combination [CHO, LOO]. Using the LOO scheme, the CLD and CHO had similar performance for large ensembles. However, the CLD outperformed the CHO and gave more accurate rankings for smaller ensembles. As the ensemble size decreased, the performance of the [CHO, LOO] combination seriously deteriorated as opposed to the [CLD, LOO] combination. Thus, it might be desirable to use the CLD with the LOO scheme when smaller ensemble size is available.

Pure and simple

DEFF Research Database (Denmark)

Mackinney-Valentin, Maria; Brun Petersen, Trine

An analysis of the rise of blandness in fashion through Adolf Loos' work on the ornament and visual sobriety......An analysis of the rise of blandness in fashion through Adolf Loos' work on the ornament and visual sobriety...

PÖFF / Egle Loo

Index Scriptorium Estoniae

Loo, Egle

2010-01-01

14. Pimedate Ööde filmifestivali filmidest: "Päris koopia" (Prantsuse-Itaalia-Iraani 2010), "Taevariik" (Rootsi-Taani 2010), "Teisel pool" (Rootsi-Soome 2010), "Tamara Drewe" (Inglise 2010), "Mesi" (Türgi-Saksa 2010), "Inimestest ja jumalatest" (Prantsuse 2010)

Les chercheurs inquiets malgre les promesses de Claudie Haignere

CERN Multimedia

2003-01-01

"Le 9 avril, lors d'un colloque sur l'innovation, la ministre deleguee a la recherche et aux nouvelles technologies a annonce, "en plein accord, dit-elle, avec le premier ministre", que "les etablissements publics a caractere scientifique et technologique (EPST) ne connaitront en 2003 aucune nouvelle annulation de credits de paiement et d'autorisations de programme" et que "les reserves de precaution sont entierement levees" (1 page).

CurriculumNet tisse sa toile | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

2 févr. 2011 ... En mars 2004, le ministre ougandais de l'Éducation et des sports, Kiddhu Makubuya, et le ministre rwandais de l'Éducation, des sciences, de la technologie et de la recherche scientifique, Romain Murenzi, ont dirigé une délégation qui a assisté à une démonstration portant sur le contenu et le matériel d'un ...

Büroo täis metsahõngu / Ell-Maaja Randküla

Index Scriptorium Estoniae

Randküla, Ell-Maaja, 1939-2016

2005-01-01

OÜ Loo Grupp büroo Tallinnas Peterburi mnt. 44. Sisekujundus: Jan Skolimowski, Arhitektuuristuudio Siim & Kreis. Ehitajad: AS Harju Ehitus ja OÜ Loo Grupp. Arhitekt Jan Skolimowskist, tema tähtsamad tööd. Ill.: plaan, 10 värv. vaadet

Lightweight object oriented structure analysis: tools for building tools to analyze molecular dynamics simulations.

Science.gov (United States)

Romo, Tod D; Leioatts, Nicholas; Grossfield, Alan

2014-12-15

LOOS (Lightweight Object Oriented Structure-analysis) is a C++ library designed to facilitate making novel tools for analyzing molecular dynamics simulations by abstracting out the repetitive tasks, allowing developers to focus on the scientifically relevant part of the problem. LOOS supports input using the native file formats of most common biomolecular simulation packages, including CHARMM, NAMD, Amber, Tinker, and Gromacs. A dynamic atom selection language based on the C expression syntax is included and is easily accessible to the tool-writer. In addition, LOOS is bundled with over 140 prebuilt tools, including suites of tools for analyzing simulation convergence, three-dimensional histograms, and elastic network models. Through modern C++ design, LOOS is both simple to develop with (requiring knowledge of only four core classes and a few utility functions) and is easily extensible. A python interface to the core classes is also provided, further facilitating tool development. © 2014 Wiley Periodicals, Inc.

20 fevrier 2012 - Le Vice-Président du Gouvernement Wallon et Ministre du Développement durable et de la Fonction Publique en charge de l’Energie du Logement et de la Recherche J.-M. Nollet, Royaume de Belgique, visite la salle de contrôle de CMS au Point 5, la caverne expérimentale CMS et le hall de tests des aimants supraconducteurs du LHC. Les chefs de département T. Lagrange et F. Hemmer accompagnent la délégation. L. Walckiers guide la visite SM18.

CERN Multimedia

Maximilien Brice

2012-01-01

20 fevrier 2012 - Le Vice-Président du Gouvernement Wallon et Ministre du Développement durable et de la Fonction Publique en charge de l’Energie du Logement et de la Recherche J.-M. Nollet, Royaume de Belgique, visite la salle de contrôle de CMS au Point 5, la caverne expérimentale CMS et le hall de tests des aimants supraconducteurs du LHC. Les chefs de département T. Lagrange et F. Hemmer accompagnent la délégation. L. Walckiers guide la visite SM18.

Scientific and Engineering Studies; Spectral Estimation.

Science.gov (United States)

1977-01-01

L NIfN-l DE6X.I,/N ISZN/16 S=IS0ED. 114-zINTI|L0OG(|FL0t.O(M)) *1.ti427,5) CALL OTRCOS(CNe,) CAL QTRCO$(cMr*t) CA6 .L "ODEUS(ZvO) CAL StBJEi,(Z5. -00...6lNES6(Z#,PLAT(IP)emLOO.) CALL SLTS*6(Zo~nelo) CALL 6141S&(Z#O.SseemLOO) CALL LLCSLL5e. CA6 .L L1NLSa(Zokl 16*einLOO.) CALL 61N4ESS(Z@1L.0-1000OO) CA6L...square error of the MC estimate § can be obtained. A significant difference now exists between treatment of the MC estimate and the MSC estimate: whereas

U.S. Army Recruiting: Improving Advertising, Community Outreach, and Social Media

Science.gov (United States)

2010-03-01

8-98) Prescribed by ANSI Std. Z39.18 USAWC STRATEGY RESEARCH PROJECT U.S. ARMY RECRUITING: IMPROVING ADVERTISING , COMMUNITY...Information Line of Operation (LOO) within its overall recruiting strategy . Increased effectiveness in this LOO ( Advertising , community outreach , and... Marketing Plan Brief, 8 October 2009 28 17 Ries, Al, and Ries, Laura. The Fall Of Advertising & The Rise Of PR (New York City: Harper Collins

Reactions of linoleic acid peroxyl radicals with phenolic antioxidants: a pulse radiolysis study

International Nuclear Information System (INIS)

Erben-Russ, Michael; Bors, Wolf; Saran, Manfred

1987-01-01

Linoleic acid peroxyl radicals (LOO) can be viewed as model intermediates occurring during lipid peroxidation processes. Formation and reactions of these species were investigated in aqueous alkaline solution using pulse radiolysis combined with kinetic spectroscopy. Irradiation of linoleic acid in N 2 O/O 2 -saturated solutions leads to a mixture of peroxyl radical isomers; reaction of 13-hydroperoxylinoleic acid (13-LOOH) with azide radicals in N 2 O-saturated solution produces 13-LOO radicals specifically. These peroxyl radicals cannot be observed directly, but their reactions with kaempferol and quercetin, acting as radical-scavenging antioxidants, produced strongly absorbing aroxyl radicals (ArO). The same aroxyl radicals were generated by OH and N 3 with rate constants exceeding 10 9 dm 3 mol -1 s -1 . Applying a reaction scheme that includes competing generation and decay reactions of both LOO and ArO radicals, individual rate constants were derived for LOO reactions with the phenols (> 10 7 dm 3 mol -1 s-? 1 ), with aroxyl radicals to form covalent adducts (> 10 8 dm 3 mol -1 s -1 ), as well as for their bimilecular decay (3.0 x 10 8 dm 3 mol -1 s -1 ). These results demonstrate high reactivity of fatty acid peroxyl radicals and flavone antioxidants in aqueous solution. (author)

At tænke stil

DEFF Research Database (Denmark)

Munch, Anders V.

2004-01-01

En overvejelse af stilbegrebets filosofiske betydning i Wien for både formsproget, kulturkritikken, historietænkningen og kunstvidenskaben. Arkitekten Adolf Loos og kunsthistorikeren Alois Riegl sammenlignes ud fra Friedrich Nietzsches historiesyn og brug af stilbegrebet.......En overvejelse af stilbegrebets filosofiske betydning i Wien for både formsproget, kulturkritikken, historietænkningen og kunstvidenskaben. Arkitekten Adolf Loos og kunsthistorikeren Alois Riegl sammenlignes ud fra Friedrich Nietzsches historiesyn og brug af stilbegrebet....

EF5 PET of Tumor Hypoxia: A Predictive Imaging Biomarker of Response to Stereotactic Ablative Radiotherapy (SABR) for Early Lung Cancer

Science.gov (United States)

2017-11-01

SABR) for Early Lung Cancer PRINCIPAL INVESTIGATOR: Billy W Loo Jr, MD PhD CONTRACTING ORGANIZATION: The Leland Stanford Junior University...Response to Stereotactic Ablative Radiotherapy (SABR) for Early Lung Cancer 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Billy W Loo Jr, MD...for early stage lung cancer in patients who are not candidates for surgery because of excessive surgical risk, and will be an important treatment option

After the Conference of United Nations Conference on Environment and Development. The aims of the state environmental policy

International Nuclear Information System (INIS)

1996-01-01

Total 162 aims of the Strategy of the state environmental policy and next followed programs, projects and measures of the environmental policy of the Slovak Republic can be grouped into 4 blocks: (1) the environmental policy in the protection of air, water and before of risk factors, in the nuclear safety and waste economy (environmental safety; (2) the environmental policy in protection of the nature and the country, protection and use of mineral surroundings, soils and forest;; (3) the environmental policy in the economy; (4) the environmental policy in the guidance, education, public information, organization, control and coordination of the ministration on the environment. These aims are grouped into 10 sectors: Sector A - Protection of the air and ozone layer; Sector B - Protection and rationalize waters use; Sector C - Waste economy; Sector D - Risk factors and nuclear safety; Sector E - The ministration on the nature and the country and land development; Sector F - The protection and using of mineral surroundings, soils and forest; Sector G - The economy of the environment; Sector H - Environmental information science and monitoring; Sector I - Environmental guidance, education, and promotion; Sector J - Organization and control of the ministration on the environment

Reactions of linoleic acid peroxyl radicals with phenolic antioxidants: a pulse radiolysis study

Energy Technology Data Exchange (ETDEWEB)

Erben-Russ, M.; Bors, W.; Saran, M.

1987-09-01

Linoleic acid peroxyl radicals (LOO) can be viewed as model intermediates occurring during lipid peroxidation processes. Formation and reactions of these species were investigated in aqueous alkaline solution using pulse radiolysis combined with kinetic spectroscopy. Irradiation of linoleic acid in N/sub 2/O/O/sub 2/-saturated solutions leads to a mixture of peroxyl radical isomers; reaction of 13-hydroperoxylinoleic acid (13-LOOH) with azide radicals in N/sub 2/O-saturated solution produces 13-LOO radicals specifically. These peroxyl radicals cannot be observed directly, but their reactions with kaempferol and quercetin, acting as radical-scavenging antioxidants, produced strongly absorbing aroxyl radicals (ArO). The same aroxyl radicals were generated by OH and N/sub 3/ with rate constants exceeding 10/sup 9/ dm/sup 3/ mol/sup -1/ s/sup -1/. Applying a reaction scheme that includes competing generation and decay reactions of both LOO and ArO radicals, individual rate constants were derived for LOO reactions with the phenols (> 10/sup 7/ dm/sup 3/ mol/sup -1/ s-./sup 1/), with aroxyl radicals to form covalent adducts (> 10/sup 8/ dm/sup 3/ mol/sup -1/ s/sup -1/), as well as for their bimilecular decay (3.0 x 10/sup 8/ dm/sup 3/ mol/sup -1/ s/sup -1/). These results demonstrate high reactivity of fatty acid peroxyl radicals and flavone antioxidants in aqueous solution.

Valeria Ränik avaldas metsiku loo

Index Scriptorium Estoniae

2007-01-01

Ränik, Valeria. Seitsme puu ja mätta taga : kaasaegne metsalugu määramata vanuses inimlastele / [fotograafid: Valeria Ränik, Velga Vitola, Ville Ränik, Petras Dabrisius]. Tartu : [V. Ränik], 2007

Visit of the King of the Belgians

CERN Multimedia

Maximilien Brice

2009-01-01

19 février 2009 - Sa Majesté Albert II, Roi des Belges et le Ministre du Climat et de l’Energie P. Magnette visitent le site experimental de CMS au Point 5 du LHC avec le Directeur de la Recherche et de l’Informatique S. Bertolucci et le Porte-parole de la Collaboration CMS T. Virdee. Tirage 02 à 08: Sa Majesté Albert II, Roi des Belges signe le livre d'or dans le SDX5 en présence du Directeur des accélérateurs et de la technologie S. Myers et du Directeur de la recherche et de l’informatique S. Bertolucci; Tirage 09 à 22: Sa Majesté Albert II, Roi des Belges et le Ministre du Climat et de l’Energie P. Magnette visitent le tunnel du LHC avec le Chef du Projet sLHC L. Evans et K. Cornelis. Tirage 23 à 35: Sa Majesté Albert II, Roi des Belges et le Ministre du Climat et de l’Energie P. Magnette visitent la cerne expérimentale de CMS avec W. Van Doninck (VUB), D. Favart (UCL) et le Porte-parole de la Collaboration T. Virdee. Tirage 36 à 50: Welcome line au Point 5 du LHC: Accueil en t...

Bayesian leave-one-out cross-validation approximations for Gaussian latent variable models

DEFF Research Database (Denmark)

Vehtari, Aki; Mononen, Tommi; Tolvanen, Ville

2016-01-01

The future predictive performance of a Bayesian model can be estimated using Bayesian cross-validation. In this article, we consider Gaussian latent variable models where the integration over the latent values is approximated using the Laplace method or expectation propagation (EP). We study...... the properties of several Bayesian leave-one-out (LOO) cross-validation approximations that in most cases can be computed with a small additional cost after forming the posterior approximation given the full data. Our main objective is to assess the accuracy of the approximative LOO cross-validation estimators...

''Textural analysis of multiparametric MRI detects transition zone prostate cancer''

Energy Technology Data Exchange (ETDEWEB)

Sidhu, Harbir S.; Johnston, Edward W.; Taylor, Stuart A.; Halligan, Steve [Centre for Medical Imaging, University College London, London (United Kingdom); University College London Hospitals NHS Foundation Trust, London (United Kingdom); Benigno, Salvatore; Dikaios, Nikos [Centre for Medical Imaging, University College London, London (United Kingdom); Ganeshan, Balaji [Institute of Nuclear Medicine, University College London, University College Hospital, London (United Kingdom); Allen, Clare; Kirkham, Alex [University College London Hospitals NHS Foundation Trust, London (United Kingdom); Groves, Ashley M. [University College London Hospitals NHS Foundation Trust, London (United Kingdom); Institute of Nuclear Medicine, University College London, University College Hospital, London (United Kingdom); Ahmed, Hashim U.; Emberton, Mark [University College London Hospitals NHS Foundation Trust, London (United Kingdom); University College London, Research Department of Urology, London (United Kingdom); Punwani, Shonit [Centre for Medical Imaging, University College London, London (United Kingdom); University College London Hospitals NHS Foundation Trust, London (United Kingdom); Centre for Medical Imaging, University College London and University College London Hospitals NIHR Biomedical Research Centre, London (United Kingdom)

2017-06-15

To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had 'significant' TZ tumour. Two radiologists in consensus matched TPM to the single axial slice best depicting tumour, or largest TZ diameter for those with benign histology, to define single-slice whole TZ-regions-of-interest (ROIs). Textural-parameter differences between single-slice whole TZ-ROI containing significant tumour versus benign/insignificant tumour were analysed using Mann Whitney U test. Diagnostic accuracy was assessed by receiver operating characteristic area under curve (ROC-AUC) analysis cross-validated with leave-one-out (LOO) analysis. ADC kurtosis was significantly lower (p < 0.001) in TZ containing significant tumour with ROC-AUC 0.80 (LOO-AUC 0.78); the difference became non-significant following exclusion of significant tumour from single-slice whole TZ-ROI (p = 0.23). T1-entropy was significantly lower (p = 0.004) in TZ containing significant tumour with ROC-AUC 0.70 (LOO-AUC 0.66) and was unaffected by excluding significant tumour from TZ-ROI (p = 0.004). Combining these parameters yielded ROC-AUC 0.86 (LOO-AUC 0.83). Textural features of the whole prostate TZ can discriminate significant prostatic cancer through reduced kurtosis of the ADC-histogram where significant tumour is included in TZ-ROI and reduced T1 entropy independent of tumour inclusion. (orig.)

Building Food Security and Social Resilience to HIV/AIDS in Malawi ...

International Development Research Centre (IDRC) Digital Library (Canada)

Previous work in Ekwendi and Kasungu (projects 100670 and 101829) identified knowledge gaps and social equity issues in the context of climate change. ... Site internet ... L'honorable Chrystia Freeland, ministre du Commerce international, ...

Enhancing Women's Economic Empowerment Through Better ...

International Development Research Centre (IDRC) Digital Library (Canada)

8 juin 2017 ... Some argue that social protection programs can reinforce traditional women's ... Agent(e) responsable du CRDI ... Le ministre du Commerce international du Canada rencontre des chercheurs soutenus par le CRDI au Chili.

[The work of Moscow communities of Sisters of Charity in own medical institutions].

Science.gov (United States)

Zorin, K V

2011-01-01

The article analyses the medical activities of Moscow communities of Sisters of Charity in curative and educational institutions organized by the communities themselves. The social ministration of communities on the territory of Moscow is considered.

Forest and Water Management for Mitigating the effects of Climate ...

International Development Research Centre (IDRC) Digital Library (Canada)

Forest and Water Management for Mitigating the effects of Climate Change in the ... Internet as a gateway in expanding choices for building adaptive capacity : a case ... L'honorable Chrystia Freeland, ministre du Commerce international, ...

Collaboration on the Issue of Violence against Women in Meghalaya

International Development Research Centre (IDRC) Digital Library (Canada)

The project will help bring together communities, police and traditional justice delivery institutions to ... Agent(e) responsable du CRDI. Singh ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un ...

Rapid point-of-care breath test for biomarkers of breast cancer and abnormal mammograms.

Directory of Open Access Journals (Sweden)

Michael Phillips

Full Text Available BACKGROUND: Previous studies have reported volatile organic compounds (VOCs in breath as biomarkers of breast cancer and abnormal mammograms, apparently resulting from increased oxidative stress and cytochrome p450 induction. We evaluated a six-minute point-of-care breath test for VOC biomarkers in women screened for breast cancer at centers in the USA and the Netherlands. METHODS: 244 women had a screening mammogram (93/37 normal/abnormal or a breast biopsy (cancer/no cancer 35/79. A mobile point-of-care system collected and concentrated breath and air VOCs for analysis with gas chromatography and surface acoustic wave detection. Chromatograms were segmented into a time series of alveolar gradients (breath minus room air. Segmental alveolar gradients were ranked as candidate biomarkers by C-statistic value (area under curve [AUC] of receiver operating characteristic [ROC] curve. Multivariate predictive algorithms were constructed employing significant biomarkers identified with multiple Monte Carlo simulations and cross validated with a leave-one-out (LOO procedure. RESULTS: Performance of breath biomarker algorithms was determined in three groups: breast cancer on biopsy versus normal screening mammograms (81.8% sensitivity, 70.0% specificity, accuracy 79% (73% on LOO [C-statistic value], negative predictive value 99.9%; normal versus abnormal screening mammograms (86.5% sensitivity, 66.7% specificity, accuracy 83%, 62% on LOO; and cancer versus no cancer on breast biopsy (75.8% sensitivity, 74.0% specificity, accuracy 78%, 67% on LOO. CONCLUSIONS: A pilot study of a six-minute point-of-care breath test for volatile biomarkers accurately identified women with breast cancer and with abnormal mammograms. Breath testing could potentially reduce the number of needless mammograms without loss of diagnostic sensitivity.

Inclusion in the Information Society in Asia | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Yet access to the Internet and to more-than-voice services is quite uneven. ... on providing assistance to Myanmar where the recent political changes have created a policy .... L'honorable Chrystia Freeland, ministre du Commerce international, ...

Building Research Capacity to Understand and Adapt to Climate ...

International Development Research Centre (IDRC) Digital Library (Canada)

Building Research Capacity to Understand and Adapt to Climate Change in the Indus Basin ... Site internet ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le ...

Universal Music Finlandi kontoriruumid = Offices of Universal Music Finland / Jan Skolimowski ; intervjueerinud Margit Mutso

Index Scriptorium Estoniae

Skolimowski, Jan, 1977-

2011-01-01

Helsingis Merimiehenkatu 36D asuvate kontoriruumide sisekujundusest. Sisearhitekt Jan Skolimowski, kaasautor Peeter Loo (KAMP Arhitektid OÜ). Graafilise disaini autor Martin Eelma (Tuumik Stuudio OÜ)

Tõuni imekitarr kõlab nagu mesi . Pedaal-steel teeb popmuusikas taassündi / Rando Tooming

Index Scriptorium Estoniae

Tooming, Rando

2009-01-01

Muusik Tõnu Timm jutustab loo, kuidas hankis Ameerikast haruldase pedaal-steel- kitarri. Eesti kasutusel olevatest vanematest pedaal-steel-kitarridest. Ansamblid, kus kasutatakse kõneall olevat kitarri

Otvetshajet Juhan Parts, premjer-ministr / Juhan Parts

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2005-01-01

Peaminister Juhan Parts selgitab Res Publica ja valitsuse korruptsioonivastast poliitikat ning loodab, et justiitsminister Ken-Marti Vaheri pakutud strateegia võitluses korruptsiooniga ei saa koalitsiooni lagunemise põhjuseks

Skazka, zakutannaja v tsvetnoi tuman / Svetlana Aleksejeva ; interv. Galina Balashova

Index Scriptorium Estoniae

Aleksejeva, Svetlana

2002-01-01

Kunstnik Sveta Aleksejevaga raamatu "Cupido & Psyche" illustreerimisest, koostööst loo tõlkijaga, USA-s raamatudisaini õppiva Leelo Märjamaaga. Raamatuillustratsioonide näitus on Rahvusraamatukogus

La construcción del Raumplan

Directory of Open Access Journals (Sweden)

Alfonso Díaz Segura

2014-02-01

Full Text Available El Raumplan es uno de los términos relacionados con la arquitectura del siglo XX con más elaboración intelectual, así como una gran incidencia en la concepción del espacio habitable. En un momento en que toda Europa se sorprendía ante las obras emanadas de las nuevas ideas sobre arquitectura, Loos contrapone su teoría presumiendo de no ser moderno. Ante interminables superficies acristaladas, él prefiere los huecos pequeños y cuidadosamente ubicados. Ante el gusto por la exhibición, Loos apuesta por el placer del voyeurismo. Frente a las superficies atectónicas de sus contemporáneos, él selecciona maderas y piedras nobles para los revestimientos de sus interiores. Finalmente, mientras sus coetáneos más mediáticos diseccionan la construcción separando la estructura del cerramiento y apostando por la estructura reticular de pilares, Loos reafi su condición pre-moderna sirviéndose del muro como elemento primario de construcción y definición espacial. El Raumplan se comprende habitando el espacio y se dibuja con dificultad pero, ¿cómo se construye? Esa es la pregunta a la que intentaremos responder.

21st October 2008 - LHC Inauguration Ceremony family photograph in SM18.

CERN Multimedia

CERN Photo Service

2008-01-01

21st October 2008 - LHC Inauguration Ceremony family photograph in SM18. Front row, from left to right : British Minister of State for Science and Innovation, Lord Drayson of Kensington; Hungarian Minister for Research, Science and Innovation K. Molnar; German Federal Minister of Education and Research A. Schavan; Slovak Deputy Prime Minister and Minister of Education J. Mikolaj; Président de la Confédération suisse P. Couchepin; Directeur général du CERN R. Aymar; Premier Ministre de la République française F. Fillon; Portuguese Minister for Science, Technology and Higher Education J. M. Gago; Ministre belge des PME, des Indépendants, de l'Agriculture et de la Politique scientifique S. Laruelle; Ambassador of Italy to the Office of the United Nations and other international organisations in Geneva G. Caracciolo di Vetri. Second row, from left to right: Czech Deputy Minister of Education, Youth and Sports, responsible for Science and Universities V. Ruzicka; Extraordinatory and Plenipotentiary Ambas...

Kadrioru loss ja selle loo killuke / Aleksandra Murre

Index Scriptorium Estoniae

Murre, Aleksandra

2008-01-01

Näitusest "Kadriorg 290. Loss ja tema lugu" Kadrioru Kunstimuuseumis. Täienduseks näitusel eksponeeritule katkend lossivalitseja J. von Gerneti (ametis 1831-1846) mälestustest, mis aitab aimu saada Kadrioru uue õitsengu algusest 19. sajandi II veerandil. Ka keiser Nikolai I ja keisrinna Aleksandra Fjodorovna visiidist Tallinna 1833. aastal

Laste joonistatud perepiltidel seisavad kõrvutud vanemad / Katrin Johanson

Index Scriptorium Estoniae

Johanson, Katrin

2008-01-01

Psühholoog Toivo Niiberg põhjustest, miks tekitab Karksi-Nuia noorteteatri dokumentaalne lavalugu "Kallid vanemad" äratundmist. Loo seadis Viljandimaa põhikooliõpilaste kirjanditest kokku teatri juht ja lavastaja Silvia Soro

Modeling Anti-HIV Activity of HEPT Derivatives Revisited. Multiregression Models Are Not Inferior Ones

International Nuclear Information System (INIS)

Basic, Ivan; Nadramija, Damir; Flajslik, Mario; Amic, Dragan; Lucic, Bono

2007-01-01

Several quantitative structure-activity studies for this data set containing 107 HEPT derivatives have been performed since 1997, using the same set of molecules by (more or less) different classes of molecular descriptors. Multivariate Regression (MR) and Artificial Neural Network (ANN) models were developed and in each study the authors concluded that ANN models are superior to MR ones. We re-calculated multivariate regression models for this set of molecules using the same set of descriptors, and compared our results with the previous ones. Two main reasons for overestimation of the quality of the ANN models in previous studies comparing with MR models are: (1) wrong calculation of leave-one-out (LOO) cross-validated (CV) correlation coefficient for MR models in Luco et al., J. Chem. Inf. Comput. Sci. 37 392-401 (1997), and (2) incorrect estimation/interpretation of leave-one-out (LOO) cross-validated and predictive performance and power of ANN models. More precise and fairer comparison of fit and LOO CV statistical parameters shows that MR models are more stable. In addition, MR models are much simpler than ANN ones. For real testing the predictive performance of both classes of models we need more HEPT derivatives, because all ANN models that presented results for external set of molecules used experimental values in optimization of modeling procedure and model parameters

National Security Reform 2010: A Mid-Term Assessment

Science.gov (United States)

2011-08-01

ministration that has not pressed Congress to do the right thing. The poster child for the lack of integrated effort is the challenge of homeland security...26, 2006, available from www.heritage.org/research/lecture/herding-cats-understanding- why-government-agencies- dont -cooperate-and-how-to-fix-the

De l'univers de la recherche à une charge publique — Interview de ...

International Development Research Centre (IDRC) Digital Library (Canada)

13 oct. 2010 ... La ministre des Finances et de l'Économie du Pérou applique les conseils en ... étaient tout désignés pour multiplier les perspectives de croissance de la ... un solide capital humain, des mécanismes permettant de faire des ...

Food Security and Climate Change in Cambodia | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Given the country's dependence on agriculture and natural resources, tackling climate change and food security together is essential. ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international ...

Kes vajab pooltõdedele rajatud patriotismi / Valle-Sten Maiste

Index Scriptorium Estoniae

Maiste, Valle-Sten, 1972-

2007-01-01

Kuressaare Linnateatri ja ühenduse R.A.A.A.M koostöös valminud dokumentaalmaterjalidel põhinevast lavastusest Betti Alverist ja Heiti Talvikust "Võlg". Loo autor on Katrin Saukas, lavastaja Merle Karusoo

Structural and electrochemical properties of La 0.8Sr 0.2Ga 1-xFe xO 3

Science.gov (United States)

Mori, Kazuhiro; Onodera, Yohei; Kiyanagi, Ryoji; Richardson, James W.; Itoh, Keiji; Sugiyama, Masaaki; Kamiyama, Takashi; Fukunaga, Toshiharu

2009-02-01

Mixed ionic-electronic conductor of Fe doped lanthanum gallate, La 0.8Sr 0.2Ga 1-xFe xO 3, has been studied by the dc four-probe method and the neutron powder diffraction. In the electrical conductivity measurement at RT, insulator-metal transition-like phenomenon was observed at around x˜0.35; this suggests an existence of the percolation limit for the electronic conductivity. Simultaneously, a bond length between O atoms, lO-O, in a MO 6 octahedron (M dbnd Ga 1-xFe x) drastically expands over x˜0.4, according to the result of crystal structure refinement based on the hexagonal phase. Such a drastic expansion in the lO-O would induce the decrease in the oxygen ionic conductivity.

Strategies For Being A Successful Physician Administrator Of A Rehabilitation Program

Institute of Scientific and Technical Information of China (English)

John L.Melvin; MD,MMSc

2008-01-01

@@ INTRODUCTION Purpose: The purpose of this paper is to provide rehabili-tation physicians with suggestions that will assist themin becoming successful program leaders/managers/ad-ministrators. The content of this paper is based uponthe experiences and observations of the author whohas had extensive experience in developing, leadingand managing rehabilitation programs.

Rapport annuel 2016-2017

International Development Research Centre (IDRC) Digital Library (Canada)

1 janv. 2018 ... Trois objectifs guident le travail du CRDI : investir dans le savoir .... intermittente ou en élaborant un programme de formation ... de collaborer avec la ministre Marie-Claude Bibeau et des ..... Le CRDI continue d'apporter son soutien avec la ...... communication et de mise en commun des connaissances.

Food and Health in Rural Lebanon : Options to Improve Dietary ...

International Development Research Centre (IDRC) Digital Library (Canada)

22 mars 2009 ... The overall goal is to devise practical interventions and policy options for improving dietary diversity, food security and health in poor and vulnerable Lebanese ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de ...

Favoriser la croissance inclusive | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

12 mai 2017 ... Les régimes de protection sociale, les transferts monétaires conditionnels et ... et de l'ancien ministre du Développement et de l'Inclusion sociale du Pérou. ... Pour un homme âgé d'Afrique de l'Ouest, les TIC représentent le ...

Water Security in Periurban South Asia : Adapting to Climate ...

International Development Research Centre (IDRC) Digital Library (Canada)

Adapting to climate change and water security in Asia : proceedings from the Regional Meeting for IDRC-funded partners in Asia working on climate change ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le ...

Reforming Security Sector Governance South Asia | CRDI - Centre ...

International Development Research Centre (IDRC) Digital Library (Canada)

In South Asia, security discourse has traditionally been confined to government circles, with no room for voices from civil society. ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international ...

Immigrant or Refugee: Perceived Effects of Colonisation of Academia by Market Forces

Science.gov (United States)

Rawlins, Peter; Hansen, Sally; Jorgensen, Lone

2011-01-01

Managers and personnel within tertiary institutions colonised by neo-liberal ministrations and buffeted by the winds of a "change culture" formed within the philosophical shifts of the last century can be considered in terms of "immigrants" or "refugees" within this new territory. The case story of this article is set…

Tere tulemast allveelaevale / Ave Alavainu

Index Scriptorium Estoniae

Alavainu, Ave, 1942-

2005-01-01

22. nov. toimub Kärdla kultuurikeskuses Nikolai Tihhonovi "Balladi naeltest" lahtine proov. Loo on tõlkinud ja lavastanud Ave Alavainu. Lavastust mängitakse ka Jõgeval toimuvatel Betti Alveri XIII luulepäevadel "Tähetund"

Suurimad rõõmuhetked on proovides / Ingo Normet ; intervjueerinud Tiina Sarv

Index Scriptorium Estoniae

Normet, Ingo, 1946-

2009-01-01

Ugalas peatselt publiku ette jõudva Kay Pollaki näidendi "Nii nagu taevas" lavastaja Ingo Normetiga näidendist, lavastaja osast loo valmimisel, tööst lavakunstikooli õppejõu ja juhatajana, teatriõppest Viljandis

Kolobok ubegajet i vozvrashajetsja ... desjat raz!

Index Scriptorium Estoniae

2005-01-01

Esmakordselt Vene Draamateater otsustas lavastada etenduse-seriaali "Kakuke", mis koosneb kümnest iseseisvast etendusest. Loo autor on J. Morozova, lavastaja A. Potuzhnõi, muusika kirjutas E. Toman ja luuletused J. Skulskaja, kunstnik on A. Korsmik

Tuletõrjehoone Põltsamaal = Fire Station in Põltsamaa / Raivo Puusepp

Index Scriptorium Estoniae

Puusepp, Raivo

2000-01-01

Projekteerija: Arhitektibüroo Reiss & Reinula. Eskiisprojekt: Arhitektibüroo Raivo Puusepp. Arhitektid Raivo Puusepp, Krista Väärtnõu, Peeter Loo. Projekt 1999, hoone valmis 2000. 10 ill. Korruste plaanid, ristlõiked, välisvaated

Population genetic data for six non-combined DNA index system ...

African Journals Online (AJOL)

The respective values for the combined power of exclusion in these populations were 0.94 and 0.99. The allele frequency data generated can be used for estimating DNA profile frequencies for the studied populations residing in South Africa. Key words: Allele frequencies, MiniSTR, DNA typing, population data, South Africa ...

José Antonio Ocampo : l'inclusion sociale et économique est ...

International Development Research Centre (IDRC) Digital Library (Canada)

14 oct. 2015 ... ... haut niveau aux Nations Unies et au sein du gouvernement colombien, notamment celui de ministre de l'Agriculture et du Développement rural, est aujourd'hui directeur du programme de développement économique et politique de la School of International and Public Affairs de la Columbia University.

Reval Hotel Lietuva Vilniuses : Konstitucijos pr. 20 / Piret Lindpere

Index Scriptorium Estoniae

Lindpere, Piret, 1963-

2004-01-01

Vilniuse hotelli "Lietuva" renoveerimine. Arhitektuurse projekti koostaja Rootsi arhitektuuribüroo AB SWECO (arhitektid Aare Saks, Nils Palm. Sisekujundus: Vaikla Disain AS (Katrin ja Argo Vaikla, Liis Lindvere, Peeter Loo). Kommenteerivad Argo ja Katrin Vaikla. 3 ill

Lenna Kuurmaa üllatas / Ode Alt

Index Scriptorium Estoniae

Alt, Ode

2008-01-01

Rainer Sarneti noortefilm "Kuhu põgenevad hinged?", stsenaariumi aluseks on Aidi Valliku romaanid Annist, kaasstsenarist Peeter Sauter, osades Ragne Veensalu, Lenna Kuurmaa jt. Filmi tootja Exitfilm. Loo autor on Tartu Descartes'i Lütseumi 12. klassi õpilane

Tele2 kutsus kliendid teatrisse ja kontsertidele

Index Scriptorium Estoniae

2007-01-01

Suvel kutsus Tele 2 kliendid Victor Hugo loo "Jumalaema kiriku kellamees" muusikalisele vaatemängule Tartus (lavastajad Urmas Lennuk ja Andres Dvinjaninov), Muhu Tulevikumuusika festivalile "Juu Jääb" ja Tallinna Linnateatri suvelavastusele "Ronk" (lavastaja Elmo Nüganen)

Ajaloo õppetunnid / Eugenio Viola

Index Scriptorium Estoniae

Viola, Eugenio, 1975-

2015-01-01

Eugenio Viola kuraatori-essee Jaanus Samma geiteemalisest kunstiprojektist "Not suitable for work. Esimehe lugu", mis esindab Eestit 56. Venezia biennaalil. Näitus jutustab fiktiivse ooperi fragmentidena esitletud installatsiooni vormis loo homoseksuaalsuses süüdistatud kolhoosiesimehest Nõukogude Eestis

Elioni turundusosakonna uus nägu = Elion's marketing department gets a makeover

Index Scriptorium Estoniae

2007-01-01

Tallinnas Endla t. 16 asuvate Elioni turundusosakonna ruumide sisekujundus. Sisearhitektuur: Jan Skolimowski ja Peeter Loo (KAMP Arhitektid). Autoritest, nende tähtsamad tööd. Plaan, 10 värv. vaadet, fotod J. Skolimowskist ja P. Loost

Norma Maja astub kindlalt tulevikku / Ain Alvela

Index Scriptorium Estoniae

Alvela, Ain, 1967-

2000-01-01

AS Norma Maja saavutas kõrged kasumi ja kasumi kasvu näitajad töötajate koondamisega. Tabel: Norma Maja valdused, AS Norma Maja areng, AS ETK Majad areng. Arvamused: Ero Toom, Ivar Lahi ja Rein Loo

Digital Review of Asia Pacific (DirAP) - Phase II | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le ... Le Panorama numérique de l'Asie-Pacifique (Digital Review of Asia Pacific ou DirAP) a pour objet de produire des connaissances et de la documentation ...

L'Islam et la femme dans l'espace public au Niger

African Journals Online (AJOL)

seriane.camara

16 sept. 2010 ... International Woman Year, women came into the public sphere, and ... comme au figuré, l'espace public (la rue, les lieux de meeting, les médias, ...... Madame Ali Mariama, Ministre du développement social, de la Population ... Butter, J., 1990, Gender Trouble: Feminism and the Subversion of Identity, New.

AGENDA 21 - the basic conceptual document - Agenda of the 21 century which was accepted on the United Nations Conference on Environment and Development (UNCED) in Rio de Janeiro in 1992. Part II. Source conservation and budget with their for the development

International Nuclear Information System (INIS)

1996-01-01

This part of the AGENDA 21 contains 14 chapters: Air protection; The integrate approach to planning and budget with sources of the country; The fight against deforestation; The ministration about instable ecosystems: the fight with desertification and with drought; The ministration about instable ecosystems: sustainable development in mountain-ranges; The support of the sustainable development of the agriculture and the country; Preservation of the biodiversity; Environmentally suitable use of the bio-technologies; The ocean preservation, all types of seas, including closed and partially closed, and coastal areas and preservation, rationally use and development of the live sources from their; Preservation of quality and stocks of the fresh-water sources: applying of integral access at the development, budget and use of the water sources; Environmentally sustainable treatment with toxic chemical substances including block off non-legal international transport of the toxic and dangerous products; Environmentally sustainable treatment with toxic chemical substances including block off non-legal international transport of the toxic and dangerous wastes; Environmentally sustainable treatment with solid wastes and sludges; (22) Safe and environmentally sustainable treatment with radioactive wastes

Voorus-porno / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2009-01-01

Stephenie Meyeri "Videviku" romaanide sari (Videvik, Noorkuu, Päikesevarjutus, Koidukuma) ja kahe esimese loo ekraniseeringud on fenomenaalselt populaarsed. PÖFFi filmikoolis arutleti teemat kirjandusagent Julian Friedmani juhtimisel. Lisaks kirjastuse Pegasus toimetaja Rene Tendermanni, kirjanik-kirjandusteoreetik Peeter Helme jt. arvamusi

Natshalsja "Lasnamjaeski bal" / Aljona Surzhikova

Index Scriptorium Estoniae

Suržikova, Aljona, 1982-

2006-01-01

9. septembril algasid filmi "Lasnamäe ball" võtted. Mati Undi 30 aastat tagasi kirjutatud loo "Sügisball" toimumispaik on Mustamäelt toodud tänapäeva Lasnamäele. Sellest ka filmi nime muutus. Filmist

Maamehed kunstitemplis = Peasants at the temple of art / Helena Risthein

Index Scriptorium Estoniae

Risthein, Helena, 1954-

2015-01-01

Rahvusvahelisel näitusel "Natuuri rikkus. Eluläheduse idee ja Düsseldorfi koolkond" Kumus jääb loo autorile silma Oskar Hoffmanni julgelt koduvillane pärand. Tartus sündinud baltisaksa maalikunstniku Oskar Hoffmanni elust ja loomingust

Demokraatliku fundamentalismi rasked päevad / Mele Pesti

Index Scriptorium Estoniae

Pesti, Mele, 1979-

2006-01-01

Autor uuris Kopenhaagenis ja Arhusis taanlaste ja Taanis elavate moslemite arusaamu Muhamedist, sõnavabadusest ja elust Taanis. Intervjuu Taani moslemite tähtsaima juhi imaam Ahmed Abu Labaniga, kes autori sõnul on nn. Muhamedi-loo rahvusvahelisele tasemele viimise taga

Animated Dreamsi festivali parimad said eile auhinnad / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2010-01-01

12. animafilmide festivali Animated Dreams grand prix' pälvis Kei Oyama film "Käeseep" (Jaapan, 2008). Parima disaini preemia sai Jonas Odelli "Tussilago" (Rootsi, 2010). Parima loo jutustas Olga ja Priit Pärna "Tuukrid vihmas" (Eesti, 2009). Teistest preemiatest

Eesti film - needusega? / Margot Visnap

Index Scriptorium Estoniae

Visnap, Margot, 1959-

2006-01-01

Mängufilm "Libahundi needus" : stsenaristid Margus Kasterpalu, Ilmar Raag ja Rainer Sarnet : režissöör Rainer Sarnet : osades Katariina Lauk, Rene Reinumägi, Raine Loo, Kersti Kreismann, Marje Metsur, Tiit Lilleorg : Shop of Dreams - Eesti Televisioon 2005

Port Artur 3 arhitektuurikonkursi võidutöö sündis Itaalias / Eno-Gerrit Link

Index Scriptorium Estoniae

Link, Eno-Gerrit

2006-01-01

Pärnu kesklinna jõeäärse ala rahvusvahelise arhitektuurikonkursi tulemustest. Võitis itaalia arhitektide projekt "Flood". Teise koha võitis projekt "Istu ja vaata" (Jan Skolimovski ja Peeter Loo), kolmanda koha "Nicesaar" (Ott Kadarik, Villem Tomiste, Mihkel Tüür)

Eesti Lähimineviku Okupatsioonide Muuseumi arhitektuurivõistlus : okupatsiooni igaveseks jäädvustamiseks = Architectural Competition of the Museum of Recent Past Occupations in Estonia : for Eternal Remembrance of the Occupation / Leonhard Lapin

Index Scriptorium Estoniae

Lapin, Leonhard, 1947-

2001-01-01

Zürii koosseis, võistlusest, võidutööst. Preemiad: I - Indrek Peil, Siiri Vallner; II - Tiina Teng, Peeter Loo; III - Reio Avaste; ostud - Andres Kask ning Markus Kaasik, Kalle Komissarov, Andres Ojari, Indrek Tiigi ja Ilmar Valdur. 5 ill.

Kas võidab teater või sihikindel needus ? / Matis Song

Index Scriptorium Estoniae

Song, Matis, 1978-

2006-01-01

Mängufilm "Libahundi needus" : stsenaristid Margus Kasterpalu, Ilmar Raag ja Rainer Sarnet : režissöör Rainer Sarnet : osades Katariina Lauk, Rene Reinumägi, Raine Loo, Kersti Kreismann, Marje Metsur, Tiit Lilleorg : Shop of Dreams - Eesti Televisioon 2005

Une technologie de pointe venue d'Asie modernise un secteur ...

International Development Research Centre (IDRC) Digital Library (Canada)

28 oct. 2010 ... En assurant une combustion plus efficace, ajoute-t-il, on utilise moins d'arbres et on réduit la pollution de l'air. En 1996, le ministre du Commerce international du Canada a remis un certificat de reconnaissance à Hari Gunasingham pour souligner sa contribution à l'avancement de la science, des affaires ...

Tabagisme, tabagisme passif, maladies chroniques et pauvreté en ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Gender and Work in the Middle East and North Africa : Research ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Toward an Innovation-led Development Path in the Philippines ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Community Driven Universal Access Solutions in Cambodia : Pilots ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Linking Research to Practice: Strengthening ICT for Development ...

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1 janv. 2012 ... Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau ...

Institutionnalisation de la formation en évaluation dans les ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Recherche et renforcement des capacités au profit des collectivités ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Enabling Bio-Innovation for Poverty Alleviation in Asia | Page 2 ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Vérification du point de vue des droits de la personne et de la paix ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Soutien institutionnel à la section de la capitale nationale du Conseil ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

STI for Development in Asia : a Platform for Information Sharing and ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Implementation of the Framework Convention on Tobacco Control in ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Improving Flood Plain Management through Adaptive Learning ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Pathways to Institutionalizing and Extending Social Protection in Asia

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Promoting Rural Income from Sustainable Aquaculture through ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Enseignements à tirer des innovations et des entreprises sociales ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Le milieu de la recherche sur les politiques en Asie du Sud et ses ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Developing a Dynamic Stochastic General Equilibrium Model for the ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Replicable Waste Recycling Project in Gianyar, Bali | CRDI - Centre ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Assisted Reproductive Technologies : Implications for Women's ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Intégration des sexospécificités et de l'équité aux recherches et aux ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Institute of Social Studies Trust (ISST) : Institutional Support | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Creating an Arab Council for the Social Sciences | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Nature et répercussions du secteur non structuré des marchés des ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Réforme des marchés du travail en Birmanie (Myanmar) | CRDI ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Financement de base de JEICP pour l'exercice 2011-2012, phase IV ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Competition Law in Action: Experiences from Developing Countries ...

International Development Research Centre (IDRC) Digital Library (Canada)

29 avr. 2007 ... Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau ...

Ressources linguistiques et système de traduction en malais ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Accroître les possibilités des jeunes dans les régions rurales en ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Ancrage de l'action caritative à la singapourienne en Asie du Sud-Est

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

MS Swaminathan Research Foundation : Organizational and ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Renforcement des capacités du comité économique de l'Assemblée ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Understanding Impunity : the Right to Truth, Justice and Reparation ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Renforcement des capacités de recherche en matière de politiques ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Enabling Bio-Innovation for Poverty Alleviation in Asia | Page 3 ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

From Tobacco to Food Production: Constraints and Transition ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Building Action for Stability in Communities (BASIC) : Training for ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Dialogue entre experts sur les accords commerciaux, la ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Application of Total Innovation Management to Chinese Small and ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Réforme du système de santé axée sur les droits et l'équité dans l ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

PAN Localization : Bahasa Indonesia Language Resources and ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Stengthening Rural Livelihoods: The Impact of Information and ...

International Development Research Centre (IDRC) Digital Library (Canada)

20 sept. 2011 ... Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau ...

Innovations for Inclusive Knowledge-based Economies in Asia ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Strengthening Resilience in Post-Disaster Situations: Stories ...

International Development Research Centre (IDRC) Digital Library (Canada)

1 oct. 2012 ... Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau ...

Building Evidence from Intervention Research on Violence Against ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Integrating Islamist Militants into the Political Process : Palestinian ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Ageing and Long-Term Care : National Policies in the Asia-Pacific ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Amélioration des moyens de subsistance agropastoraux dans le ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Strengthening Women Survivors of Violence in Post-Conflict ...

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Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Evaluation of an Integrated Intervention to Stop Tobacco Use among ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Étude sur l'entrepreneuriat dalit : Regard sur 25 % de la population ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Forum sur le développement et la politique de la concurrence - 2007 ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Enforcing Competition Rules in South Africa : Thieves at the Dinner ...

International Development Research Centre (IDRC) Digital Library (Canada)

1 mars 2013 ... Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau ...

Global Partners, un programme de petites subventions pour les ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Multinationals and East Asian Integration | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Support to the Consultative Group on International Agricultural ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Soutien à la recherche économique et sociale aux fins de la ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

in_focus - Fighting Poverty with Facts: Community-Based Monitoring ...

International Development Research Centre (IDRC) Digital Library (Canada)

1 janv. 2009 ... Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau ...

Réseau sur le développement humain et la capacité - phase III ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Croissance et développement inclusifs : Collaboration CRDI et ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Évaluation de l'activité entrepreneuriale dans la région MOAN ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Partenariats efficaces et durables en recherche sur la santé : un ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

VIH/sida, mondialisation et vulnérabilité | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Strengthening Social Science Research in Iraq - Phase II | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

China Public Budget Reform Program (CPBR) - Phase II | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

À la défense des migrantes en Amérique latine | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

Collaborative Learning for Co-management of Natural Resources in ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

DVD. Sweeney Todd : Fleet Streeti deemonlik habemeajaja / Egle Loo

Index Scriptorium Estoniae

Loo, Egle

2008-01-01

Lühiarvustus õudusmuusikalist "Sweeney Todd : The Demon Barber of Fleet Street" Stephen Sondheimi muusikali alusel : režissöör Tim Burton : peaosades Johnny Depp, Helena Bonham Carter : Ameerika Ühendriigid - Suurbritannia 2007

Sõjast ei jää keegi puutumata / Egle Loo

Index Scriptorium Estoniae

Loo, Egle

2010-01-01

Režissöör Jim Sheridani film "Vennad" (USA, 2009), peaosades Jake Gyllenhaal ja Tobey Maguire. Film on Taani režissööri Susanne Bieri samanimelise filmi uusversioon (Taani-Suurbritannia-Rootsi-Norra, 2004)

Avatakse Eesti muusika hulgiladu / Indrek Loo ; interv. Siim Nestor

Index Scriptorium Estoniae

Loo, Indrek

2007-01-01

Käesoleval nädalal internetis käivituvast projektist Music Online, kuhu on plaanis helifailidena kõigile huvilistele tasu eest kättesaadavaks teha kogu Eestis välja antud muusika - klassikast hip-hopini (projekti muuska-alast järelevalvet teostab Priit Pajusaar)

MODELLING THE INHIBITORY ACTIVITY ON CARBONIC ANHYDRASE IV OF SUBSTITUTED THIADIAZOLE - AND THIADIAZOLINE - DISULFONAMIDES: INTEGRATION OF STRUCTURE INFORMATION

Directory of Open Access Journals (Sweden)

Sorana Daniela Bolboaca

2006-07-01

Full Text Available ABSTRACT:Purpose: To analyze the relationships between inhibitory activities on carbonic anhydrase IV and structures of substituted 1,3,4-thiadiazole and 1,3,4-thiadiazoline disulfonamide through integration of compounds complex structure information by the use of Molecular Descriptors Family.Method: A number of forty compounds were used to generate and compute the molecular descriptors family and to build structure-activity relationships models. The obtained multi-varied models (the models with two, respectively with four descriptors were validated by computing the cross-validation leave-one-out score (r2cv-loo, and analyzed through assessment of the squared correlation coefficients (r2, and the models stability (r2 - r2cv-loo. The estimation abilities of the multi-varied MDF-SAR model with four descriptors were analyzed in training and test sets.Results: Analysis of the obtained models shows that the best results was obtained by the multi-varied model with four molecular descriptors (r2 = 0.920. The prediction abilities of this model is sustained by the cross validation leave-one-out score (r2cv-loo = 0.903, the model stability (r2 - r2cv-loo = 0.017, and the results on training versus test analysis (no significant differences between correlation coefficients in training and test sets, p > 0.05. The multi-varied model which used four descriptors proved to render higher value of correlation coefficient comparing with previous reported models (p 0.05. El modelo multivariante que utilizó cuatro descriptores mostró un valor más alto del coeficiente de correlación en comparación con los modelos divulgados anteriormente (p < 0.01.Conclusión: El modelo multivariante con cuatro descriptores es sólido y fiable e indica que la actividad de la inhibición en la carboanhidrasa IV producida por las sufonamidas sustituidas del 1,3,4-tiadiazol- y de la 1,3,4-tiadiazolina- dependen de la naturaleza de la geometría y de la topología del compuesto

Villa Rohuneemes = Villa at Rohuneeme / Raivo Puusepp

Index Scriptorium Estoniae

Puusepp, Raivo

2002-01-01

Projekteerija: Arhitektibüroo R. Puusepp. Arhitekt Raivo Puusepp, kaasa töötasid Krista Väärtnõu, Peeter Loo, Urve Konts. Haljastus: Mart Kalm, sisekujundus: Kaire Kemp, konstruktsioonid ja eriosad: A-Grupp. Projekt ja ehitus 2001. 8 ill.: plaanid, vaated

African Journal of Biotechnology - Vol 11, No 55 (2012)

African Journals Online (AJOL)

Folic acid supplementation is not the sole factor in determining neural tube defects: The possible role of autoantibodies · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Keat Wei Loo, Siew Hua Gan, 11767-11771 ...

Lühianimafilm "Väike lühinägelik boamadu" võitis UNICEF-i auhinna

Index Scriptorium Estoniae

2007-01-01

A Film Eesti lastelühianimafilm (loo autor Andry Ervald, režissöörid Aina Järvine ja Meelis Arulepp) tunnistati parimaks haridus- ja sotsiaalteemaliseks filmiks 19.-22. aprillini Itaalias toimunud "Cartoons on the Bay" festivalil ja sai Pulcinella auhinna

[Henning v. Wistinghausen. Freimaurer in Estland. Ihre sozialstruktur am Beispiel der Revaler Loge "Isis" 1773-1820] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2007-01-01

Arvustus: Henning v. Wistinghausen: Freimaurer in Estland. Ihre sozialstruktur am Beispiel der Revaler Loge "Isis" 1773-1820. In : Quatuor Coronati 42 (2005), lk. 287-305. Eesti vabamüürlaskonna sotsiaalsest koosseisust Tallinn loo̓i Isis (1773-1820) näitel

QSAR Modeling of COX -2 Inhibitory Activity of Some Dihydropyridine and Hydroquinoline Derivatives Using Multiple Linear Regression (MLR) Method.

Science.gov (United States)

Akbari, Somaye; Zebardast, Tannaz; Zarghi, Afshin; Hajimahdi, Zahra

2017-01-01

COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure-activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R 2 ) of 0.972 and 0.531 for training and test groups, respectively. The quality of the model was evaluated by leave-one-out (LOO) cross validation (LOO correlation coefficient (Q 2 ) of 0.943) and Y-randomization. We also employed a leverage approach for the defining of applicability domain of model. Based on QSAR models results, COX-2 inhibitory activity of selected data set had correlation with BEHm6 (highest eigenvalue n. 6 of Burden matrix/weighted by atomic masses), Mor03u (signal 03/unweighted) and IVDE (Mean information content on the vertex degree equality) descriptors which derived from their structures.

Kuidas ma pistiseskandaali sattusin / Jan Jõgis-Laats

Index Scriptorium Estoniae

Jõgis-Laats, Jan

2007-01-01

Eesti Ekspressis 27. septembril ilmunud artiklis kirjutatakse USA-s algatatud uurimisest Iraagi ülesehitusprogrammi raha võimaliku väärkasutamise üle. Jan Jõgis-Laats kirjeldab sündmuste jada, et selgitada selle loo tausta, millesse on väidetavalt ka tema kaasatud

Gorod vozdushnõh sharov / Jevgenia Gorski

Index Scriptorium Estoniae

Gorski, Jevgenia

2003-01-01

Keila linna tutvustavas loos on juttu Keila linnavalitsuse galeriis toimunud näitustest. Hetkel eksponeeritakse taani kunstniku Peder Stougaardi töid. Olev Soansi infograafika püsinäitusest Keila linnavalitsuses ja Harjumaa muuseumis. Püsinäituse asukoht linnavalitsuses tähistatakse memoriaaltahvliga

New Investigations at Fossil Fields of Proosa, North Estonia / Valter Lang, Margot Laneman

Index Scriptorium Estoniae

Lang, Valter, 1958-

2006-01-01

Proosa fossiilsed põllud avastati 1992. aastal. Pärast osa maa erastamist firmale Loo Auto OÜ lükati seal buldooseriga ära kogu paepõhja kattev pinnas, millega hävitati kõik jäljed kunagisest põlluharimisest. Päästeuuringutest 2005. aastal

Kontorihoone : Järvevana tee 9g, Tallinn = Office Building : 9g Järvevana Str., Tallinn / Raivo Puusepp

Index Scriptorium Estoniae

Puusepp, Raivo

2003-01-01

Merko Ehituse 6-korruseline suletud kabinetsüsteemis büroohoone. Arhitekt Raivo Puusepp, kaasa töötasid Maike Heido ja Peeter Loo. Sisekujundaja Kaire Kemp (ArtAku). Konstruktiivne lahendus: Neoprojekt. Projekt 2001, valmis 2003. I korruse plaan, sise- ja 2 välisvaadet

Paul Dundes Wolfowitz. Aukus sokkidega pistrik nõelub mainet / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2007-01-01

Maailmapanga president Paul Wolfowitz teatas pressikonverentsil, et soovib tööd jätkata. Paul Wolfowitzi karjäärist, päritolust, eraelust ja usalduse kaotamisest korruptsioonihõngulise loo pärast oma sõbratarile Shaha Ali Rizale palgatõusu nõudmisel

Annonce d'un important financement dans le cadre de la visite de la ...

International Development Research Centre (IDRC) Digital Library (Canada)

20 sept. 2016 ... Après avoir entendu les témoignages d'étudiants actuels et d'anciens étudiants sur l'incidence positive du programme, la ministre Bibeau a annoncé une contribution de 22,6 millions CAD du Canada sur cinq ans (le CRDI gérera 19,6 millions CAD provenant d'Affaires mondiales Canada et 3 millions CAD ...

Mondialisation et réforme des sommets internationaux : Le L-20, un ...

International Development Research Centre (IDRC) Digital Library (Canada)

18 déc. 2008 ... Cet ouvrage, qui comprend un avant-propos de Gordon Smith et une postface du très honorable Paul Martin, ancien premier ministre du Canada, ainsi qu'un glossaire, fournit une rare occasion d'apprécier de l'intérieur les mécanismes de la gouvernance internationale et ses perspectives d'avenir.

Folic acid supplementation is not the sole factor in determining ...

African Journals Online (AJOL)

Folic acid supplementation is not the sole factor in determining neural tube defects: The possible role of autoantibodies. Keat Wei Loo, Siew Hua Gan. Abstract. Neural tube defects (NTDs) are severe but common congenital malformations. Neonates who suffer from NTDs may experience long-term complications throughout ...

Defense Small Business Innovation Research Program (SBIR). Volume 2. Navy Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

Science.gov (United States)

1990-04-01

SYSTEM WILL BE DEVELOPED IN PHASE II. LAGUNA RESEARCH LAB 3015 RAINBOW GLEN FALLBROOK, CA 92028 CONTRACT NUMBER: HENDRICUS G LOOS TITLE: SEAWATER...PHASE II. PAGE AUTOMATED TELECOMMUNICATIONS SYS PO BOX 188 - RTE 2 LA HONDA , CA 94020 CONTRACT NUMBER: PATRICIA WIENER TITLE: NEW PACKAGING TECHNOLOGIES

Cuba a la Deriva en un Mundo Postcommunista (Cuba Adrift in a Postcommunist World)

Science.gov (United States)

1993-01-01

movimientos disidentes y defensores do los derechos humanos on )a isla, Algo quo ha venido haciendo Espaila, no asi Mkxico. La conclusifn a la cual...probable. Aunque loo poqueflos grupos do disidentes y defensores do los derecho . humenos ban proliferedo, otroo elementos do la sociedad civil cubena

Ulmekas Eesti moodi / Dagne Hanschmidt

Index Scriptorium Estoniae

Hanschmidt, Dagne

2005-01-01

Ulmelise lühimängufilmi "Kärbseudu" võtted Põlvamaal Ottenis. Režissöör, üks stsenariste ja produtsent on Tallinna Ülikooli filmi ja video eriala viimase kursuse tudeng Janek Karakatsh, näitlejaiks Raine Loo, Aapo Ilves, Igor Maasik (Onu Bella)

Time-course effects of carbendazim in the infundibulum of the ...

African Journals Online (AJOL)

At TEM level, pyknosis, karyorrhexis, swollen mitochondria, dilated RER cisternae, increased number of lysosomes and vacuoles were observed from 24 hours post-exposure. Compound cilia and loos of striated rootlets were also observed. Thickening and duplication of the basal lamina were identified from 12 days ...

Hea maine avab südameid / Aune Past

Index Scriptorium Estoniae

Past, Aune, 1954-

2008-01-01

Autor selgitab, et suhtekorraldus on pidev ja plaanipärane tegevus, mille tulemusena lähenevad organisatsiooni soovitud imago ja avalik kuvand teineteisele. Suhtekorraldus ei tähenda kehvast asjast hästi rääkimist, vaid tõel ja faktidel põhineva loo jutustamist

A genomic audit of newly-adopted autosomal STRs for forensic identification.

Science.gov (United States)

Phillips, C

2017-07-01

In preparation for the growing use of massively parallel sequencing (MPS) technology to genotype forensic STRs, a comprehensive genomic audit of 73 STRs was made in 2016 [Parson et al., Forensic Sci. Int. Genet. 22, 54-63]. The loci examined included miniSTRs that were not in widespread use, but had been incorporated into MPS kits or were under consideration for this purpose. The current study expands the genomic analysis of autosomal STRs that are not commonly used, to include the full set of developed miniSTRs and an additional 24 STRs, most of which have been recently included in several supplementary forensic multiplex kits for capillary electrophoresis. The genomic audit of these 47 newly-adopted STRs examined the linkage status of new loci on the same chromosome as established forensic STRs; analyzed world-wide population variation of the newly-adopted STRs using published data; assessed their forensic informativeness; and compiled the sequence characteristics, repeat structures and flanking regions of each STR. A further 44 autosomal STRs developed for forensic analyses but not incorporated into commercial kits, are also briefly described. Copyright © 2017 Elsevier B.V. All rights reserved.

The Structure and Financial Dimensions of Public Administration in EU Countries

Directory of Open Access Journals (Sweden)

Martina HALÁSKOVÁ

2015-06-01

Full Text Available Various traditional trends and roles of pub-lic administration can be traced across the Eu-ropean Union member states. These countries, however, are obliged to abide by common ad-ministrative and legal principles of the European administrative area. This paper focuses on the structure and differentiation of public adminis-tration in EU (28 countries, levels of local gov-ernment and internal division of administrative structures, using the ESA methodology and a comparison of expenditures made by public ad-ministration in 2003, 2009 and 2013. The f scal aspect of public administration is evaluated also through f scal decentralization (revenues, expen-ditures. Cluster analysis is used for the com-parison of selected areas of public expenditures according to the levels of public administration, showing that EU (28 countries can be divided into three clusters.The most signif cant differences in public ex-penditures according to levels of public adminis-tration were observed in EU countries in the f rst and third cluster, where f scal decentralization of expenditures constitutes the most notable differ-ence. The smallest differences in all clusters are perceived in total general government expendi-tures as % of GDP.

QSAR study on the histamine (H3 receptor antagonists using the genetic algorithm: Multi parameter linear regression

Directory of Open Access Journals (Sweden)

Adimi Maryam

2012-01-01

Full Text Available A quantitative structure activity relationship (QSAR model has been produced for predicting antagonist potency of biphenyl derivatives as human histamine (H3 receptors. The molecular structures of the compounds are numerically represented by various kinds of molecular descriptors. The whole data set was divided into training and test sets. Genetic algorithm based multiple linear regression is used to select most statistically effective descriptors. The final QSAR model (N =24, R2=0.916, F = 51.771, Q2 LOO = 0.872, Q2 LGO = 0.847, Q2 BOOT = 0.857 was fully validated employing leaveone- out (LOO cross-validation approach, Fischer statistics (F, Yrandomisation test, and predictions based on the test data set. The test set presented an external prediction power of R2 test=0.855. In conclusion, the QSAR model generated can be used as a valuable tool for designing similar groups of new antagonists of histamine (H3 receptors.

Publications | Page 56 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cap sur l'Ouest : les Prairies canadiennes, élément essentiel de la lutte contre la faim dans le monde. Il y a plus de vingt ans, Charlie Mayer, exploitant d'un ranch dans le sud du Manitoba et également ministre fédéral de l'Agriculture, est rentré au Canada troublé par ce qu'il avait entendu.

U.S. EPA, Pesticide Product Label, BONIDE TOMATO-PEPPER-VEGETABLE SPRAY, 09/07/1983

Science.gov (United States)

2011-04-13

I ~ " r \\ (Lahel Prart) , op'·'lin·· \\·:it', rOL". or "0.1. 'In not .~11(,,: loo·;{' ,irt to cov('r h.\\ it. ':n~~ci!'it; .lirL'l.-"ri,lll": for ro\\.~l.(\\t ~:o~\\llt'r~. :10 not appl~' hy ...

Mart Saali ja Lüütsepa Jaani taevaskäigud. Protestantlikest ilmutustest, nende poeesiast ja motiivistikust / Andreas Kalkun

Index Scriptorium Estoniae

Kalkun, Andreas, 1977-

2006-01-01

Analüüsitakse kahe 18. sajandi lõpul sündinud ning vennastekogudusest inspireeritud usulise ärkamise ja nn taevaskäijate liikumisega seotud eesti mehe ilmutusi. Kirjeldatakse ka protestantlike voolude ja sektidega seotud ilmutustenägijate traditsiooni ning teatud aspekte kristlikus ilmutustenägemise loos üldse

ESS Grupi peahoone Tallinnas, Tondil

Index Scriptorium Estoniae

2000-01-01

Staabihoone rekonstrueerimine kontorihooneks. Välisarhitektuur säilitati algsel kujul, fassaadid restaureeriti. Ajaloolised eritingimused Liivi Künnapu. Projekteerija: Arhitektibüroo Raivo Puusepp OÜ, arhitektid Raivo Puusepp, Toivo Tammik, Peeter Loo, Krista Väärtnõu, sisekujundaja Kaire Kemp-Tisler. Projekt 1999, valmis 2000. 11 ill.: korruste plaanid, vaated

Micro filtration membrane sieve with silicon micro machining for industrial and biomedical applications

NARCIS (Netherlands)

van Rijn, C.J.M.; Elwenspoek, Michael Curt

1995-01-01

With the use of silicon micromachining an inorganic membrane sieve for microfiltration is constructed, having a siliconnitride membrane layer with thickness typically 1 pm and perforations typically between 0.5 pm and 10 pm in diameter. As a support a -silicon wafer with openings of loo0 pm in

A Hold-out method to correct PCA variance inflation

DEFF Research Database (Denmark)

Garcia-Moreno, Pablo; Artes-Rodriguez, Antonio; Hansen, Lars Kai

2012-01-01

In this paper we analyze the problem of variance inflation experienced by the PCA algorithm when working in an ill-posed scenario where the dimensionality of the training set is larger than its sample size. In an earlier article a correction method based on a Leave-One-Out (LOO) procedure...

Emmaste kell pälvis üleilmset tähelepanu / Priit Pullerits

Index Scriptorium Estoniae

Pullerits, Priit, 1965-

2001-01-01

Lugu Emmaste kiriku kellast jõudis Associated Pressi kaudu paljudesse maailma infokanalitesse. Kalifornia firma Critical Mass Films kavatseb vändata mängufilmi Hiiumaal Emmaste kiriku kella peitmise loost II Maailmasõja ja järgnenud okupatsiooni ajal. Kella peitmise ja leidmise loo pani kirja AP Balti korrespondent M. Tarm

Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: I. Principles and some general algorithms.

Science.gov (United States)

Langenbucher, Frieder

2002-01-01

Most computations in the field of in vitro/in vivo correlations can be handled directly by Excel worksheets, without the need for specialized software. Following a summary of Excel features, applications are illustrated for numerical computation of AUC and Mean, Wagner-Nelson and Loo-Riegelman absorption plots, and polyexponential curve fitting.

Renforcement en vue d'une nouvelle stratégie en matière de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les élections du 20 avril 2008 au Paraguay ont mis fin à soixante et un ans de domination unipartite. Avec l'avènement du nouveau gouvernement, un partenaire de longue date du CRDI, le Centro de Análisis y Difusión de la Economía Paraguaya (CADEP), a vu son directeur général accéder au poste de ministre des ...

India | Page 107 | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Il y a plus de vingt ans, Charlie Mayer, exploitant d'un ranch dans le sud du Manitoba et également ministre fédéral de l'Agriculture, est rentré au Canada troublé par ce qu'il avait entendu au cours d'une réunion de l'Organisation des Nations Unies pour l'alimentation et l'agriculture (FAO), à Rome. Read more about Cap ...

Sexospécificités | Page 176 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Il y a plus de vingt ans, Charlie Mayer, exploitant d'un ranch dans le sud du Manitoba et également ministre fédéral de l'Agriculture, est rentré au Canada troublé par ce qu'il avait entendu au cours d'une réunion de l'Organisation des Nations Unies pour l'alimentation et l'agriculture (FAO), à Rome. Read more about Cap ...

Defense Logistics Agency Computer-Aided Acquisition and Logistics Support Security Measures

Science.gov (United States)

1989-09-29

sopisit ftre a nduate eiromensweaonsyte dt i vaiou mdi, nfrrngcls- having security features commensurate with today’s weapon system data in various media ...sections, ministrator that has completed an accredited three areas of improvement in security emphasis are APscrt orebfr htst a ecn deemed appropriate...May 1989, been in a hardcopy media and in accordance with Washington, D.C. specific contract clauses and FAR/DFAR. Through CALS, the Government shall

La création d'une culture de controle? Les intentions politiques derrière la genèse des Sanctions Administratives Communales

NARCIS (Netherlands)

Devroe, E.

2015-01-01

C’est le 3 mars 1999, en fin de législature, qu’est introduit par les ministres de la Justice et de l’Intérieur de l’époque Tony Van Parijs et L. Van den Bossche, le projet de loi sur les sanctions administratives communales[1] (connue sous le nom de «Loi SAC). La loi devait être votée et il y avait

Architecture and Assessment: Privacy Preserving Biometrically Secured Electronic Documents

Science.gov (United States)

2015-01-01

very large public and private fingerprint databases comprehensive risk analysis and system security contribution to developing international ...Safety and Security Program which is led by Defence Research and Development Canada’s Centre for Security Science, in partnership with Public Safety...201 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 201 Science and Engineering

Cyber Capability Development Centre (CCDC) Private Cloud Design

Science.gov (United States)

2014-11-01

download the relevant ZIP update packages from VMware public repository and saving the downloads to an internal repository. A repository will need to be...Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014...Remote Desktop Connectivity from DND Networks ........................................................ 63 8.1.1 Secure Remote Access ( Internal

Intelligence Virtual Analyst Capability: Governing Concepts and Science and Technology Roadmap

Science.gov (United States)

2014-12-01

Canada, as represented by the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre...Statistic literature analysis involving publication velocity, trend analysis, and patent analysis was conducted. DRDC-RDDC-2014-R156 3...University, Stanford University, IBM, Microsoft, Avaya, SRI International , and Alcatel Lucent were identified as key players in the ISA research

Self-improving Inference System to Support the Intelligence Preparation of the Battlefield: Requirements, State of the Art, and Prototypes

Science.gov (United States)

2014-12-01

droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 Abstract …….. This report presents the results of...documents coming from the international military community (doctrine, manuals) as well as from the academia (scientific papers). From this analysis, a...References ..... [1] US Military, “US Joint Intelligence Preparation of the Operational Environment”, Joint Publication 2-01.3, 16 June

Cap sur l'Ouest : les Prairies canadiennes, élément essentiel de la ...

International Development Research Centre (IDRC) Digital Library (Canada)

1 mai 2014 ... Il y a plus de vingt ans, Charlie Mayer, exploitant d'un ranch dans le sud du Manitoba et également ministre fédéral de l'Agriculture, est rentré au Canada troublé par ce qu'il avait entendu au cours d'une réunion de l'Organisation des Nations Unies pour l'alimentation et l'agriculture (FAO), à Rome.

Modernistid modernismi vastu : Loos, Schenker ja ilustuste kriitika / Nicolas Cook

Index Scriptorium Estoniae

Cook, Nicolas

2008-01-01

Seoseid tänapäeva tuntuima muusikaanalüüsi meetodi leiutaja Heinrich Schenkeri teooria ja Viini modernistliku arhitekti Adolf Loosi ornamendikriitika vahel. Ettekanne Pärnu Nüüdismuusika Päevade konverentsil 2005

Ministeerium osutas lüngale tankeri loos / Ingvar Bärenklau

Index Scriptorium Estoniae

Bärenklau, Ingvar, 1967-

2006-01-01

Keskkonnaministeeriumi hinnang uurimise alla sattunud kütusetanker Probo Koala seaduserikkumisele Paldiski sadamas. Rahvusvahelise konventsiooni järgi ei pea laevad sadamas deklareerima lastipesuvee täpset koostist

Põhja konn paneb veerema loo armastusest ja reetmisest / Kaile Kabun

Index Scriptorium Estoniae

Kabun, Kaile

2007-01-01

Muinasjuttu "Põhja konn" Fr. R. Kreutzwaldi muinasjutu ainetel esietendatakse 31. mail Papa Kreutzwaldi Õueteatris Kreutzwaldi majamuuseumi õuel. Kaalukamatesse rollidesse on valitud Võru vene gümnaasiumi õpilased

Comparison of plant nutrient levels between compost from Sky loo ...

African Journals Online (AJOL)

Recent scholars have highlighted the benefit of harvesting compost from eco-san toilets for application as plant nutrients. However, levels of nutrients in eco-san compost may vary depending on the type of toilet and also the type of top soil in a particular geographical region. This study compared levels of nitrogen, ...

"Aasta betoonehitis 2015" ülejäänud nominendid

Index Scriptorium Estoniae

2016-01-01

Jõhvi riigigümnaasium, Maxima logistikakeskus, Võru riigigümnaasium, Rakvere Tark Maja, Viljandi krematoorium-tavandisaal, Marsi tänava korterelamud Tallinnas Tondil, Kultuurikatel Tallinnas, Kentmanni tn 6 elu- ja ärihoone Tallinnas, Kehärata rongitunneli kaarelemendid Helsingi lennujaama all, Kroodi viaduktid Loo-Maardu teelõigul, ühepereelamu Põldmarja 12 Tartus

Остальные номинанты на премию "Лучшее бетонное строение 2015"

Index Scriptorium Estoniae

2016-01-01

Jõhvi riigigümnaasium, Maxima logistikakeskus, Võru riigigümnaasium, Rakvere Tark Maja, Viljandi krematoorium-tavandisaal, Marsi tänava korterelamud Tallinnas Tondil, Kultuurikatel Tallinnas, Kentmanni tn 6 elu- ja ärihoone Tallinnas, Kehärata rongitunneli kaarelemendid Helsingi lennujaama all, Kroodi viaduktid Loo-Maardu teelõigul, ühepereelamu Põldmarja 12 Tartus

432 püksipaari Riia kongresside palee fassaadil / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2000-01-01

Filmifestivalil "Arsenals" sai parima režissööri kujukese Mait Laas nukufilmi "Teekond Nirvaanasse" eest, teise koha preemia Valentin Kuigi mängufilm "Lurjus" ja Riho Undi nukufilm "Saamuel internetis". Peaauhinna andis loos shoti naisrežissööri Lynne Ramsay mängufilmile "Rotipüüdja" ("Ratcatcher")

Klaasist kodu / Ivi Piho

Index Scriptorium Estoniae

Piho, Ivi, 1959-

2003-01-01

Klaasikunstniku Agnes Tormi ja Mati Tormi perekonna uus kodu. 145 mø eramu projekteeris arhitekt Heiki Teras. Mööbel valiti IKEA kataloogidest, köögimööbel telliti Eesti firmalt Loo Mööbel, klaasist detailid on valmistatud Disainklaasis. Klaasist on kappide uksed, lauaplaadid, dushikabiin, vannitoa uks jm. 13 ill

The Medium Tactical Vehicle Replacement Program-An Analysis of a Multi-Service Army and Marine Corps Product Office

Science.gov (United States)

2004-06-01

employ more than 700 personnel. The squadron has four different aircraft: the CH-53E Super Stallion , the CH-46E Sea Knight, the VH-3D Sea King and...Raymond Product Manager Dennis Haag Systems Analyst MAJ Scott Alexander APM Tom Frankquist Dpty Product Manager MAJ Mike Loos APM Barb Wlodek Secretary

Self-Reflection

DEFF Research Database (Denmark)

Fausing, Bent

2016-01-01

will take a look at the establishing of the modern self and possibilities of self-reflection, too. My examples will be from the so-called dark-selfies and from a new selfie form, which merge the present with the previous progressing into the future. I will discuss the media reflections as loos and/or gain...

Molecular Mechanics with an Array Processor.

Science.gov (United States)

1982-06-01

34 to be submritted. 40 B. W. Kernrihan and D M Ritchie, The CPm guniw.g Language, Prentice- Hall. Eaglewood Cliffs, New Jersey, 1978. 60 D. J. Adams , in...1400 Washington Avenue Ban e o Albany, New York 12203 La J la, California 92093 Dr. Rank Loos Professor C. A. Ansell Latuna Research Laboratory

Effects of various forms of lipopolysaccharide on the expression of ...

African Journals Online (AJOL)

Jane

2011-10-05

Oct 5, 2011 ... Lan-jun Bai1, Wings TY Loo2,3,4*, Yiding Dou4, Min Wang5, Hao Liang5, Mary NB Cheung3,4,6 ... The levels of lactate dehydrogenase (LDH), N-terminal pro ...... Li G-R, Sun H-Y, Chen J-B, Zhou Y, Tse H-F, Lau C-P (2009).

"Vargamäe kuningriik". "Oscar ja Roosamamma. Kirjad Jumalale" / Tauno Teder

Index Scriptorium Estoniae

Teder, Tauno

2007-01-01

Autor soovitab vaadata Endla ja Rakvere Teatri suvelavastust "Vargamäe kuningriik" A. H. Tammsaare "Tõe ja õiguse" I ja V osa ainetel, lavastajaks Jaanus Rohumaa ning E.-E. Schmitti loo järgi sündinud näidendit "Oscar ja Roosamamma. Kirjad Jumalale". Lavastaja ja peaosas Üllar Saaremäe, Rakvere Teater

A Pandemic Influenza Preparedness Study: Use of Energetic Methods to Decontaminate Filtering Facepiece Respirators Contaminated with H1N1 Aerosols and Droplets (POSTPRINT)

Science.gov (United States)

2012-06-01

the Occupational Safety and Health Ad- ministration ( OSHA ) and the Centers for Disease Control and Prevention (CDC) to recommend that HCWs wear a...unique feature of the present study is the con - trolled contamination of FFRs with H1N1 influenza us- ing aerosol methods, which provide a radically...components can pro - tect the virus from some decontamination technolo- gies. In the droplet challenge, the droplets do not dry completely, but land on

CSSP Environmental Scan 2013

Science.gov (United States)

2014-09-01

en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC-2014-R83 i Abstract...participate in terrorist acts is a priority for these groups, because such operatives have easy access to Europe and North America ” [13]. Although...of diseases as varied as malaria, dengue fever, Lyme disease, and West Nile virus [59]. 14 DRDC-RDDC-2014-R83 References

The Future of Allied Air Power: The United States Air Force

Science.gov (United States)

2014-10-01

Center for Strategic & International Studies, 6 February 2014), http://csis.org/ publication /us-strategy-and-added-sanctions-iran-role- administration...Washington D.C.: Center for Strategic & International Studies, 6 February 2014, http://csis.org/ publication /us-strategy-and-added-sanctions- iran-role...Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC-2014-R82 i

Malware Memory Analysis of the Jynx2 Linux Rootkit (Part 1): Investigating a Publicly Available Linux Rootkit Using the Volatility Memory Analysis Framework

Science.gov (United States)

2014-10-01

represented by the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense...analysis techniques is outside the scope of this work, as it requires a comprehensive study of operating system internals and software reverse engineering...2 Peripheral concerns 2.1 Why examine Linux memory images or make them available? After extensively searching the available public

Automated Border Control Systems as Part of e-border Crossing Process

Science.gov (United States)

2015-01-01

which is led by Defence Research and Development Canada’s Centre for Security Science, in partnership with Public Safety Canada. The project was led...Canada, as represented by the Minister of National Defence, 2015 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de...FAST US,EU (2013): AVATAR kiosks Examples: US, Canada: Deployed in Vancouver, Montreal, Toronto, and Chicago International Airports

Evidence Base for the Development of an Enduring DND/CAF Operational Energy Strategy (DOES): Expressing Canadian Values Through Defence Operational Energy Stewardship Here and Abroad

Science.gov (United States)

2014-12-01

exceptional energy densities. When including internal plus external components the volumetric 46 https://www.gov.uk/government/ publications /dcdc-global...and Hebabi, M. (2010), Canadian Energy Security: What Does Energy Security Mean for Canada?, Graduate School of Public and International Affairs...as represented by the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la

Modelling Metrics for Mine Counter Measure Operations

Science.gov (United States)

2014-08-01

the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014...a random search derived by Koopman is widely used yet it assumes no angular dependence (Ref [10]). In a series of publications considering tactics...Node Placement in Sensor Localization by Optimization of Subspace Principal Angles, In Proceedings of IEEE International Conference on Acoustics

The Effective Use of Reserve Personnel in the U.S. Military: Lessons from the United Kingdom Reserve Model

Science.gov (United States)

2015-01-01

reason provided by all consulted was administrative blunders and the poor quality of training , which had been outsourced in an effort to cut costs ... cost - cutting outsourcing deal resulted in the number of people joining up fall- ing by more than a third.”96 Figures obtained by the newspaper...numerous problems have arisen over the ad- ministration of new recruits as well as basic training , which has also been outsourced to a private contrac

Gordon Houlden | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

... dernier poste qu'il y a occupé étant celui de directeur général, Direction générale de l'Asie orientale. Avant cela, il avait été ministre à l'ambassade du Canada à Beijing, puis directeur général du Bureau commercial du Canada à Taipei, après avoir occupé divers postes de haut rang à Hong Kong, Varsovie et La Havane.

Army Sustainment. Volume 44, Issue 2, March-April 2012

Science.gov (United States)

2012-04-01

b.a. deGree in criMinal justice adMinistration froM con- cordia colleGe in MicHiGan. He is leVel iii certified in loGistics ManaGeMent and leVel ii...book and unit supply), plant maintenance, finance, and Defense Forces and Public Security (DFPS). Together, these modules provide enhanced...maintenance-related information for all assigned assets. The plant maintenance module provides users with equipment readiness and enhanced personnel

Proceedings of the 2011 AFMS Medical Research Symposium. Volume 5. Operational Medicine (In-Garrison Care) Track

Science.gov (United States)

2012-02-01

8217 Lumbar flexion and straight leg raise ’I’ Bilateral hip range of motion assessment ’I’ Trunk endurance tests ’P Ultrasound Imaging ’I’ Laterat...Providing Great Care ... Buiidirlg wa.mor Medics--- - ---- \\..1 Not just a problem for retirees • ~ ·~ "" II’ -------------- Dti ~looAmwica’sMGdicaJAir

Edouard Thouvenel et l’Union des Principautés Roumaines (1856-1859

Directory of Open Access Journals (Sweden)

Iulian Oncescu

2010-12-01

Full Text Available La personnalité d’Edouard Thouvenel, diplomate français dont le nom a été le plus fréquemment lié de la réalisation de l’Union des Principautés, le long des années 1856-1859, est souvent et justement invoquée dans la compréhension de cette séquence importante de l’histoire moderne des Roumains du milieu du XIX-ème siècle. Né le 11 novembre 1818, à Verdun, entré en diplomatie en 1841, chargé avec des affaires et ministre plénipotentiaire (entre 1846-1849 à Athènes et ensuite à München (en 1851, Edouard Thouvenel a été nommé directeur des Affaires politiques dans le Ministère des Affaires Etrangères de la France en février 1852. En 1854, sa carrière est sauvée par Napoléon III lui-même; celui-ci le nomme ambassadeur à Constantinople en pleine guerre de Crimée (3mai 1855. Il a exercé cette fonction pendant cinq années, 1855-1860, période marquée par le Congrès de Paris, par la question des Principautés Roumaines et le début du problème italien, qui a provoqué la démission du ministre des Affaires Etrangères en fonction, Alexandre Walewski, en décembre 1859. Donc, successeur de Walewski, Edouard Thouvenel a occupé la fonction de ministre des Affaires Etrangères jusqu’en 1862, lorsqu’il demissionera. Les années à suivre, il a été le président de la Compagnie de Chemins de Fer d’Est, ensuite grand référendaire du Sénat, en 1865. Thouvenel a tombé malade en 1866 et il est mort le 23 octobre, à seulement 48 années, justement au moment où on préparait son retour à Quay d’Orsay.

A Bayesian Approach to Estimating Detection Performance in a Multi-Sensor Environment

Science.gov (United States)

2014-09-01

National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC...emphasis can be seen in CF publications such as the Maritime Capability Planning Guidance (MCPG) 2010 [3]. To make effective use of these new remote...fixed installation, ship, aircraft, or satellite. Ships of a certain size or type are required by the International Maritime Organization (IMO) to

Using Sentence-Level Classifiers for Cross-Domain Sentiment Analysis

Science.gov (United States)

2014-09-01

National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC...domain sentiment classification via spectral feature alignment. In Proceedings of the 19th international conference on World Wide Web, WWW ’10...Dennis, S. 5. DATE OF PUBLICATION (Month and year of publication of document.) September 2014 6a. NO. OF PAGES (Total containing information

Residences Satisfaction Towards Service Quality Provided By Bogor Local Government

OpenAIRE

Setiawan, Budi; Oswari, Teddy; Kuswanto, Adi

2011-01-01

The lowest local government as a frontline government has some crucial duties in­cludes residences administration, village development, residences identity, land ad­ministration, and other duties. Up to present, the performance of the lowest local government is measured based on the regulation, but has never been measured based on the perception of its residences that have had service directly. The objective of the study are(1) to explore whether there is a differences between the perception ...

Mälestuskilde Emilie Bertelsonist / Joosep Koppel

Index Scriptorium Estoniae

Koppel, Joosep

2013-01-01

Juhtumist 1930. aastatel, kui Kükita misjonijaamale saadeti Rootsist annetusena riideid ja jalatseid, kuid mille Tallinna Tolliamet maksustas 300-kroonise maksuga. Misjonär Emilie Bertelsoni rollist loo lahendamisel. Lisatud foto traktaat-ajakirjast Prizõv (Призыв), mida andis välja Emilie Bertelson koostöös rootsi misjonär Nils Angeliniga aastatel 1928-1935

Report by the Delegate for major risks for 2010; Rapport 2010 du delegue aux risques majeurs

Energy Technology Data Exchange (ETDEWEB)

Michel, Laurent [Ministere de l' Ecologie, du Developpement durable, des Transports et du Logement, Grande Arche, Tour Pascal A et B, 92055 La Defense Cedex (France)

2011-07-01

The first part of this report comments the major natural and industrial disasters which occurred in 2010 in France (Xynthia tempest, flooding, and forest fires) and in other countries. It also proposes some lessons from these disasters. The second part discusses the evolution towards a resilient society by a combined approach of sustainable development, of cultural good safeguarding, and person protection. It also discusses a prospective approach regarding natural hazards and technological accidents, adapted procedures, governance and land planning, the evolution of information and alarm systems, and emerging risks. The third part addresses the adaptation to natural hazards: frameworks and strategies, actions (regulatory prevention, flooding management, safety of hydraulic works, seismic plan). It assesses the financial and budgetary means brought by the State and its partners, and discusses some perspectives. It addresses the technological risks: legal and regulatory evolutions, safety of hazardous industrial installations, consequences of technological accidents. The next part deals with the control of civilian nuclear installations by the ASN. The last part presents the different involved structures and authorities

Balansseerimine abstraktse liikumise ning tähendusliku loo vahel / Evelin Lagle

Index Scriptorium Estoniae

Lagle, Evelin

2008-01-01

"Augusti tantsufestival" Tallinnas Kanuti gildi saalis 21.-31. VIII 2008. Tantsulavastustest "Gallina Aquatica", "Creating Sense", "Mi madre y yo", "Ball", "Radiodance", "And I just stood there watching the sky and the people below"

Prediction of the maximum absorption wavelength of azobenzene dyes by QSPR tools

Science.gov (United States)

Xu, Xuan; Luan, Feng; Liu, Huitao; Cheng, Jianbo; Zhang, Xiaoyun

2011-12-01

The maximum absorption wavelength ( λmax) of a large data set of 191 azobenzene dyes was predicted by quantitative structure-property relationship (QSPR) tools. The λmax was correlated with the 4 molecular descriptors calculated from the structure of the dyes alone. The multiple linear regression method (MLR) and the non-linear radial basis function neural network (RBFNN) method were applied to develop the models. The statistical parameters provided by the MLR model were R2 = 0.893, Radj2=0.893, qLOO2=0.884, F = 1214.871, RMS = 11.6430 for the training set; and R2 = 0.849, Radj2=0.845, qext2=0.846, F = 207.812, RMS = 14.0919 for the external test set. The RBFNN model gave even improved statistical results: R2 = 0.920, Radj2=0.919, qLOO2=0.898, F = 1664.074, RMS = 9.9215 for the training set, and R2 = 0.895, Radj2=0.892, qext2=0.895, F = 314.256, RMS = 11.6427 for the external test set. This theoretical method provides a simple, precise and an alternative method to obtain λmax of azobenzene dyes.

Prediction of the GC-MS Retention Indices for a Diverse Set of Terpenes as Constituent Components of Camu-camu (Myrciaria dubia (HBK Mc Vaugh Volatile Oil, Using Particle Swarm Optimization-Multiple Linear Regression (PSO-MLR

Directory of Open Access Journals (Sweden)

Majid Mohammadhosseini

2014-05-01

Full Text Available A reliable quantitative structure retention relationship (QSRR study has been evaluated to predict the retention indices (RIs of a broad spectrum of compounds, namely 118 non-linear, cyclic and heterocyclic terpenoids (both saturated and unsaturated, on an HP-5MS fused silica column. A principal component analysis showed that seven compounds lay outside of the main cluster. After elimination of the outliers, the data set was divided into training and test sets involving 80 and 28 compounds. The method was tested by application of the particle swarm optimization (PSO method to find the most effective molecular descriptors, followed by multiple linear regressions (MLR. The PSO-MLR model was further confirmed through “leave one out cross validation” (LOO-CV and “leave group out cross validation” (LGO-CV, as well as external validations. The promising statistical figures of merit associated with the proposed model (R2train=0.936, Q2LOO=0.928, Q2LGO=0.921, F=376.4 confirm its high ability to predict RIs with negligible relative errors of predictions (REP train=4.8%, REP test=6.0%.

Economic Feasibility of a Siderostat-fed Liquid Mirror Telescope for Surveillance of Space

Science.gov (United States)

2015-04-01

by the Minister of National Defence, 2015 © Sa Majesté la Reine (en droit du Canada), telle que réprésentée par le ministre de la Défense nationale...Forces (CAF) conducts Surveillance of Space (SofS) in con- junction with international partners, primarily the United States. The constantly increasing...Surveillance Network (SSN) maintains a public catalog of almost 90001 RSOs [1], ranging in size down to about 10 cm in Low Earth Orbit (LEO) [2]. The

Geographical Information System Redefined for Tourism

OpenAIRE

K, Srinivasan; Anand, V Nath

2004-01-01

In Kerala, the revenue generated by tourism i assessed as 6.29% of GDP and the employment in tourism is estimated as 7 lakhs. Total investments worth over Rs.500 Cr. has come into Kerala on account of the State's prioritizing the creation of basic infrastructure to support tourism and adopting a policy that i eco-friendly and environmentally sustainable says Kerala's Tourism's ministrer in 2003. The importance of information technology in increasing in all the sectors. Tourism one of the larg...

Lühinägelik boamaopoiss müttab festivalidel

Index Scriptorium Estoniae

2007-01-01

A Film Eesti joonisfilm "Väike lühinägelik boamadu" (loo autor Andry Ervald, režissöörid Aina Järvine ja Meelis Arulepp) on üks viiest Pulcinella auhinna 2007 nominendist Itaalia animafilmifestivalil Cartoons on the Bay. Detsembris 2006 osales film IX olümpia rahvusvahelisel laste- ja noortefilmide festivalil, kus žürii valis ta parimaks lühianimafilmiks

The Sun murrab Baltimaadesse ja Soome

Index Scriptorium Estoniae

2008-01-01

Aprillis andis ansambel Tanel Padar & The Sun Soomes, Lätis, Leedus ja Eestis üksteist kontserti. Heliplaadi "Here Gomes The Sun" lugu "Hopelessness You" on Soome raadiote tipp 300s neljakümnendal kohal, lugu "Learn the game" on Leedu FM99 raadios 33 enim mängitava loo seas, laul "One of those days" saavutas Läti raadio SWH rokkmuusika edetabelis teise koha.

The Mechanosensitive Ca2+ Channel as a Central Regular of Prostate Tumor Cell Migration and Invasiveness

Science.gov (United States)

2011-04-01

sion [83], glioma [123], glaucoma [78] atherosclerosis [22, 134], Duchenne muscular dystrophy [44, 45], and tumor- igenesis [128]. Furthermore...healing [137] and promote neuronal regeneration [76]. Of particular note is Duchenne muscular dystrophy (DMD), a devastating X-linked genetic disease...channels in stretch-induced muscle damage: role in muscular dystrophy . Clin Exp Pharmacol Physiol 31:551–556 181. Zampighi GA, Kreman M, Boorer KJ, Loo DDF

Nucleic Acid Quadratic Indices of the “Macromolecular Graph’s Nucleotides Adjacency Matrix”. Modeling of Footprints after the Interaction of Paromomycin with the HIV-1 Ψ-RNA Packaging Region

Directory of Open Access Journals (Sweden)

Eduardo A. Castro

2004-11-01

Full Text Available This report describes a new set of macromolecular descriptors of relevance to nucleic acid QSAR/QSPR studies, nucleic acids’ quadratic indices. These descriptors are calculated from the macromolecular graph’s nucleotide adjacency matrix. A study of the interaction of the antibiotic Paromomycin with the packaging region of the RNA present in type-1 HIV illustrates this approach. A linear discriminant function gave rise to excellent discrimination between 90.10% (91/101 and 81.82% (9/11 of interacting/noninteracting sites of nucleotides in training and test set, respectively. The LOO crossvalidation procedure was used to assess the stability and predictability of the model. Using this approach, the classification model has shown a LOO global good classification of 91.09%. In addition, the model’s overall predictability oscillates from 89.11% until 87.13%, when n varies from 2 to 3 in leave-n-out jackknife method. This value stabilizes around 88.12% when n was > 3. On the other hand, a linear regression model predicted the local binding affinity constants [log K (10-4M-1] between a specific nucleotide and the aforementioned antibiotic. The linear model explains almost 92% of the variance of the experimental log K (R = 0.96 and s = 0.07 and LOO press statistics evidenced its predictive ability (q2 = 0.85 and scv = 0.09. These models also permit the interpretation of the driving forces of the interaction process. In this sense, developed equations involve short-reaching (k < 3, middle-reaching (4 < k < 9 and far-reaching (k = 10 or greater nucleotide’s quadratic indices. This situation points to electronic and topologic nucleotide’s backbone interactions control of the stability profile of Paromomycin-RNA complexes. Consequently, the present approach represents a novel and rather promising way to chem & bioinformatics research.

SU-E-J-85: Leave-One-Out Perturbation (LOOP) Fitting Algorithm for Absolute Dose Film Calibration

International Nuclear Information System (INIS)

Chu, A; Ahmad, M; Chen, Z; Nath, R; Feng, W

2014-01-01

Purpose: To introduce an outliers-recognition fitting routine for film dosimetry. It cannot only be flexible with any linear and non-linear regression but also can provide information for the minimal number of sampling points, critical sampling distributions and evaluating analytical functions for absolute film-dose calibration. Methods: The technique, leave-one-out (LOO) cross validation, is often used for statistical analyses on model performance. We used LOO analyses with perturbed bootstrap fitting called leave-one-out perturbation (LOOP) for film-dose calibration . Given a threshold, the LOO process detects unfit points (“outliers”) compared to other cohorts, and a bootstrap fitting process follows to seek any possibilities of using perturbations for further improvement. After that outliers were reconfirmed by a traditional t-test statistics and eliminated, then another LOOP feedback resulted in the final. An over-sampled film-dose- calibration dataset was collected as a reference (dose range: 0-800cGy), and various simulated conditions for outliers and sampling distributions were derived from the reference. Comparisons over the various conditions were made, and the performance of fitting functions, polynomial and rational functions, were evaluated. Results: (1) LOOP can prove its sensitive outlier-recognition by its statistical correlation to an exceptional better goodness-of-fit as outliers being left-out. (2) With sufficient statistical information, the LOOP can correct outliers under some low-sampling conditions that other “robust fits”, e.g. Least Absolute Residuals, cannot. (3) Complete cross-validated analyses of LOOP indicate that the function of rational type demonstrates a much superior performance compared to the polynomial. Even with 5 data points including one outlier, using LOOP with rational function can restore more than a 95% value back to its reference values, while the polynomial fitting completely failed under the same conditions

TU-H-BRC-09: Validation of a Novel Therapeutic X-Ray Array Source and Collimation System

Energy Technology Data Exchange (ETDEWEB)

Trovati, S; King, GJ; Loo, BW; Maxim, P; Schueler, E; Wang, J; Wang, L [Stanford University School of Medicine, Palo Alto, California (United States); Borchard, P [Tibaray Inc, San Francisco, California (United States); Limborg, CG; McCormick, D; Nicolas, LY; Tantawi, S [Stanford Linear Accelerator, Menlo Park, CA (United States)

2016-06-15

Purpose: We have experimentally characterized and simulated the dosimetric properties and spatial fidelity of a novel X-ray array source and collimation system called SPHINX that has the potential to generate complex intensity modulated X-ray beams by varying the electron beam intensity only, and without any moving parts like in multi-leaf collimators. Methods: We investigated the spatial fidelity and the X-ray performances of a SPHINX prototype in tungsten, using a Cyber Knife and the experimental high-energy electron beam line at XTA at SLAC National Laboratory. Dose distributions were recorded with gafchromic films, placed at the distal end of SPHINX and at several depths in a solid water phantom. The geometry of SPHINX and of the experimental set-ups was also modeled in Monte Carlo (MC) simulations with the FLUKA code, used to reproduce the experimental results and, after validation, to predict and optimize the performance and design of the SPHINX. Results: The results indicate significant particle leakage through the channels during a single-channel irradiation for high incident energies, followed by a rapid decrease for energies of clinical interest. When the collimator channels are used as target, the photon production increases, however at expense of the beam size that is also enlarged. The illumination of all channels simultaneously shows a fairly even transmission of the beam. Conclusion: With the measurements we have verified the MC models and the uniformity of beam transmission through SPHINX, and we have evaluated the importance of particle leakage through adjacent channels. These results can be used to optimize SPHINX design through the validated MC simulations. Funding: Weston Havens Foundation, Office of the Dean of Medical School and Office of the Provost (Stanford University). Loo, Maxim, Borchard, Tantawi are co-founders of TibaRay Inc. Loo and Tantawi are TibaRay Inc. board members. Loo and Maxim received grants from Varian Medical Systems and

TU-H-BRC-09: Validation of a Novel Therapeutic X-Ray Array Source and Collimation System

International Nuclear Information System (INIS)

Trovati, S; King, GJ; Loo, BW; Maxim, P; Schueler, E; Wang, J; Wang, L; Borchard, P; Limborg, CG; McCormick, D; Nicolas, LY; Tantawi, S

2016-01-01

Purpose: We have experimentally characterized and simulated the dosimetric properties and spatial fidelity of a novel X-ray array source and collimation system called SPHINX that has the potential to generate complex intensity modulated X-ray beams by varying the electron beam intensity only, and without any moving parts like in multi-leaf collimators. Methods: We investigated the spatial fidelity and the X-ray performances of a SPHINX prototype in tungsten, using a Cyber Knife and the experimental high-energy electron beam line at XTA at SLAC National Laboratory. Dose distributions were recorded with gafchromic films, placed at the distal end of SPHINX and at several depths in a solid water phantom. The geometry of SPHINX and of the experimental set-ups was also modeled in Monte Carlo (MC) simulations with the FLUKA code, used to reproduce the experimental results and, after validation, to predict and optimize the performance and design of the SPHINX. Results: The results indicate significant particle leakage through the channels during a single-channel irradiation for high incident energies, followed by a rapid decrease for energies of clinical interest. When the collimator channels are used as target, the photon production increases, however at expense of the beam size that is also enlarged. The illumination of all channels simultaneously shows a fairly even transmission of the beam. Conclusion: With the measurements we have verified the MC models and the uniformity of beam transmission through SPHINX, and we have evaluated the importance of particle leakage through adjacent channels. These results can be used to optimize SPHINX design through the validated MC simulations. Funding: Weston Havens Foundation, Office of the Dean of Medical School and Office of the Provost (Stanford University). Loo, Maxim, Borchard, Tantawi are co-founders of TibaRay Inc. Loo and Tantawi are TibaRay Inc. board members. Loo and Maxim received grants from Varian Medical Systems and

SU-E-J-85: Leave-One-Out Perturbation (LOOP) Fitting Algorithm for Absolute Dose Film Calibration

Energy Technology Data Exchange (ETDEWEB)

Chu, A; Ahmad, M; Chen, Z; Nath, R [Yale New Haven Hospital/School of Medicine Yale University, New Haven, CT (United States); Feng, W [New York Presbyterian Hospital, Tenafly, NJ (United States)

2014-06-01

Purpose: To introduce an outliers-recognition fitting routine for film dosimetry. It cannot only be flexible with any linear and non-linear regression but also can provide information for the minimal number of sampling points, critical sampling distributions and evaluating analytical functions for absolute film-dose calibration. Methods: The technique, leave-one-out (LOO) cross validation, is often used for statistical analyses on model performance. We used LOO analyses with perturbed bootstrap fitting called leave-one-out perturbation (LOOP) for film-dose calibration . Given a threshold, the LOO process detects unfit points (“outliers”) compared to other cohorts, and a bootstrap fitting process follows to seek any possibilities of using perturbations for further improvement. After that outliers were reconfirmed by a traditional t-test statistics and eliminated, then another LOOP feedback resulted in the final. An over-sampled film-dose- calibration dataset was collected as a reference (dose range: 0-800cGy), and various simulated conditions for outliers and sampling distributions were derived from the reference. Comparisons over the various conditions were made, and the performance of fitting functions, polynomial and rational functions, were evaluated. Results: (1) LOOP can prove its sensitive outlier-recognition by its statistical correlation to an exceptional better goodness-of-fit as outliers being left-out. (2) With sufficient statistical information, the LOOP can correct outliers under some low-sampling conditions that other “robust fits”, e.g. Least Absolute Residuals, cannot. (3) Complete cross-validated analyses of LOOP indicate that the function of rational type demonstrates a much superior performance compared to the polynomial. Even with 5 data points including one outlier, using LOOP with rational function can restore more than a 95% value back to its reference values, while the polynomial fitting completely failed under the same conditions

New multiplexes for Europe-amendments and clarification of strategic development

DEFF Research Database (Denmark)

Gill, Peter; Fereday, Lyn; Morling, Niels

2006-01-01

benefits to detect degraded samples. We subsequently recommended adoption of three new mini-STR loci to improve the success rate of degraded DNA markers, concurrent with the reduction in size of the existing STR markers in current use. This also improves the discriminating power of the system which...... to provide smaller amplicons combined with an additional two loci of high discriminating power. Eventually, the two strategies will converge to provide a single multiplex of 15 STR loci. The process will be guided by the ENFSI/EDNAP groups....

VENUS Ranging Study

Science.gov (United States)

2014-12-01

Majesté la Reine (en droit du Canada), telle que réprésentée par le ministre de la Défense nationale, 2014 Abstract The underwater acoustic propagation...50 km des capteurs sous-marins situés aux nœuds du réseau VENUS dont les données acoustiques et sismiques sont accessibles au public sur Internet...Southwest British Columbia, Geophysical Journal International , 170(2), 800–812. [15] Hamilton, E. L. (1979), Vp/Vs and Poisson’s ratios in marine

Un ministre britannique inaugure au CERN les journées WWW

CERN Multimedia

CERN Press Office. Geneva

1995-01-01

On 8 March, UK Science Minister David Hunt opened CERN's 'World-Wide Web Days', a conference designed to give journalists, educators and communication experts a practical introduction to this new telecommunications revolution. Citing CERN's invention of the Web as the latest in a long line of unforseeable spin-offs, the Minister praised the vital role played by fundamental research: "By working at the extreme limits of present technology", said Hunt, "CERN and other basic research laboratories help to break new technological ground and sow the seeds of what will become mainstream manufacturing in the future."

The value of Non-CODIS miniSTR genotyping systems in forensic ...

African Journals Online (AJOL)

Recently, research into genetic typing systems has focused on making use of multiplex polymerase chain reaction (PCR) systems that have a reduced size of the PCR products, to improve the molecular analysis of degraded DNA samples in particular. Non-CODIS (NC) loci were therefore developed to aid the profiling of ...

Naised vereimejate ümber / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2009-01-01

Stephenie Meyeri "Videviku" romaani-saaga (Videvik, Noorkuu, Päikesevarjutus, Koidukuma) ja kahe esimese loo ekraniseeringud on fenomenaalselt populaarsed. Märkimisväärsed naised fenomeni loojate hulgas peale kirjanik Stephenie Meyeri on Bella osatäitja Kristen Stewart, filmide soundtrack'ide koostaja Alexandra Patsavas, sarja esimese filmi režissöör Catherine Hardwicke, saaga filmide stsenarist Melissa Rosenberg ja rock-bändi Paramore lauljatar Hayley Williams

Seed dissemination in small clearcuttings in north-central California

Science.gov (United States)

Philip M. McDonald

1980-01-01

In a 1964-1967 study on the Challenge Experimental Forest, seedfall was evaluated in 2-, 5-, and 10-acre circular clearcuttings. During the 4 years, 10 seed crops, ranging from light to bumper, were produced by ponderosa pine. white fir, Douglas-fir, and incense cedar. Seedfall ranged from 76 to 40,691 sound seed per acre (188 to lOO,547/ha) for a single species in a...

Insegnare moduli di “Arte, Scienze e Tecnologie di Rappresentazione Grafica”: quali sfide per il futuro?

Directory of Open Access Journals (Sweden)

Agata Lo Tauro

2014-02-01

The research co llaboration between educational institutions will provide impo rtant findings to inform imp rovements to imp lement educational strategies and overall design of novel research projects. We are loo king forward to embarking on this project and seeing how the research results will influence the Science and technologies for graphical representation, both in Europ e and internationally. This is a work-in progress.

Novel method of assessing delamination of the anterior lens capsule using spectral-domain optical coherence tomography

OpenAIRE

Tan, Deborah KL; Aung, Tin; Perera, Shamira A

2012-01-01

Deborah KL Tan,1 Tin Aung,1–3 Shamira A Perera1,21Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3National University of Singapore, Yong Loo Lin School of Medicine, SingaporeBackground: Delamination of the anterior lens capsule producing a double-ring sign during continuous curvilinear capsulorhexis is commonly associated with true exfoliation syndrome.Methods: Previous studies have concentrated on light- and transmission-electron microscopic...

Impact of radiofrequency radiation on DNA damage and antioxidants in peripheral blood lymphocytes of humans residing in the vicinity of mobile phone base stations.

Science.gov (United States)

Zothansiama; Zosangzuali, Mary; Lalramdinpuii, Miriam; Jagetia, Ganesh Chandra

2017-01-01

Radiofrequency radiations (RFRs) emitted by mobile phone base stations have raised concerns on its adverse impact on humans residing in the vicinity of mobile phone base stations. Therefore, the present study was envisaged to evaluate the effect of RFR on the DNA damage and antioxidant status in cultured human peripheral blood lymphocytes (HPBLs) of individuals residing in the vicinity of mobile phone base stations and comparing it with healthy controls. The study groups matched for various demographic data including age, gender, dietary pattern, smoking habit, alcohol consumption, duration of mobile phone use and average daily mobile phone use. The RF power density of the exposed individuals was significantly higher (p base stations, showed significantly (p base station/s. The analysis of various antioxidants in the plasma of exposed individuals revealed a significant attrition in glutathione (GSH) concentration (p < 0.01), activities of catalase (CAT) (p < 0.001) and superoxide dismutase (SOD) (p < 0.001) and rise in lipid peroxidation (LOO) when compared to controls. Multiple linear regression analyses revealed a significant association among reduced GSH concentration (p < 0.05), CAT (p < 0.001) and SOD (p < 0.001) activities and elevated MN frequency (p < 0.001) and LOO (p < 0.001) with increasing RF power density.

Structure-Activity Relationship Models for Rat Carcinogenesis and Assessing the Role Mutagens Play in Model Predictivity

Science.gov (United States)

Carrasquer, C. Alex; Batey, Kaylind; Qamar, Shahid; Cunningham, Albert R.; Cunningham, Suzanne L.

2016-01-01

We previously demonstrated that fragment based cat-SAR carcinogenesis models consisting solely of mutagenic or non-mutagenic carcinogens varied greatly in terms of their predictive accuracy. This led us to investigate how well the rat cancer cat-SAR model predicted mutagens and non-mutagens in their learning set. Four rat cancer cat-SAR models were developed: Complete Rat, Transgender Rat, Male Rat, and Female Rat, with leave-one-out (LOO) validation concordance values of 69%, 74%, 67%, and 73%, respectively. The mutagenic carcinogens produced concordance values in the range of 69–76% as compared to only 47–53% for non-mutagenic carcinogens. As a surrogate for mutagenicity comparisons between single site and multiple site carcinogen SAR models was analyzed. The LOO concordance values for models consisting of 1-site, 2-site, and 4+-site carcinogens were 66%, 71%, and 79%, respectively. As expected, the proportion of mutagens to non-mutagens also increased, rising from 54% for 1-site to 80% for 4+-site carcinogens. This study demonstrates that mutagenic chemicals, in both SAR learning sets and test sets, are influential in assessing model accuracy. This suggests that SAR models for carcinogens may require a two-step process in which mutagenicity is first determined before carcinogenicity can be accurately predicted. PMID:24697549

From Animals to Animats: Proceedings of the International Conference on Simulation of Adaptive Behavior (1st) Held in Paris, France on 24-28 September 1990

Science.gov (United States)

1991-08-31

attitudes comportementales, etc...) et d’autre part sur la pertinence des mod~1es de la representation a~u vivant et de I’animalit6. 11 dlabore des syst...l’incapacit6 du vivant saisir le vivant par les mithodes conventionnelles et propose une strat6gie "hypocrisique" par la construction de leurres...11 organise de nombreuses manifestations dont "Le Vivant et l’Artificiel’ au Festival d’Avignon en 1984 et obtient une bourse de recherche du Minist~re

Ma jutustan teile oma loo : märkmeid aastast 1998 / Lilian Vellerand

Index Scriptorium Estoniae

Vellerand, Lilian, 1932-

1999-01-01

Eesti teatrite hooajast 1998 ja tagasivaateid minevikku. Pikemalt on vaatluse all P. Jalaka "Libahunt", mida võrreldakse varasemate lavastustega (M. Mikiveri lavastused 1968,1974, 1986), ja L. Petersoni "Antigone"(võrreldakse 1982. aasta lavastusega). Kasut. kirjandus lk. 14

Water Operations Technical Support Program. Water Quality Management for Reservoirs and Tailwaters. Report 1. In-Reservoir Water Quality Management Techniques

Science.gov (United States)

1989-01-01

Harrison was Chief, EL. Drs. J. Barko, J. Mahloch, H. Westerdahl , K. Getsinger, R. Engler, T. Wright, and H. Smith, EL; Messrs. E. Theriot and L. Decell...Brown (1978); Janik, Taylor, and Barko (1980); Hanson and Stefan (1984); Westerdahl and Getsinger (1988). Theory and Design Herbicides and algicides...the plant is unclear except that it behaves like an auxin (Loos 1975, Westerdahl and Hall 1983). The herbicide 2,4-D is particularly effective against

Variance Function Estimation. Revision.

Science.gov (United States)

1987-03-01

UNLSIFIED RFOSR-TR-87-±112 F49620-85-C-O144 F/C 12/3 NL EEEEEEh LOUA28~ ~ L53 11uLoo MICROOP REOUINTS-’HR ------ N L E U INARF-% - IS %~1 %i % 0111...and 9 jointly. If 7,, 0. and are any preliminary estimators for 71, 6. and 3. define 71 and 6 to be the solutions of (4.1) N1 IN2 (7., ’ Td " ~ - / =0P

Homsed disaini- ja furnituurilahendused

Index Scriptorium Estoniae

2007-01-01

Müügijuht Galina Sepp 2006. a. asutatud mööbliettevõttest AIS Furniture (Advanced Interior Solutions), mille tootmistsehh asub Harjumaal Loo alevikus, salong Tallinnas Pärnu mnt. 66. Toodetakse eritellimusel mööblit kööki, elu- ja vannituppa, garderoobi, büroosse ning abiruumidesse. AIS Furniture disaineritelt saab tellida kogu maja või korteri sisekujunduse koos mööbliga. Köökide tehnilised lahendused on pärit furnituuritootjatelt

WE-AB-202-08: Feasibility of Single-Inhalation/Single-Energy Xenon CT for High-Resolution Imaging of Regional Lung Ventilation in Humans

International Nuclear Information System (INIS)

Pinkham, D; Schueler, E; Diehn, M; Mittra, E; Loo, B; Maxim, P; Negahdar, M; Yamamoto, T

2016-01-01

quantify regional lung ventilation volumetrically with high resolution using widely accessible radiologic equipment. Bill Loo and Peter Maxim are founders of TibaRay, Inc. Bill Loo is also a board member. Bill Loo and Peter Maxim have received research grants from Varian Medical Systems, Inc. and RaySearch Laboratory

WE-D-BRE-02: BEST IN PHYSICS (THERAPY) - Radiogenomic Modeling of Normal Tissue Toxicities in Prostate Cancer Patients Receiving Hypofractionated Radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Coates, J; Jeyaseelan, K; Ybarra, N; David, M; Faria, S; Souhami, L; Cury, F; Duclos, M; Naqa, I El [McGill University, Montreal, QC (Canada)

2014-06-15

Purpose: It has been realized that inter-patient radiation sensitivity variability is a multifactorial process involving dosimetric, clinical, and genetic factors. Therefore, we explore a new framework to integrate physical, clinical, and biological data denoted as radiogenomic modeling. In demonstrating the feasibility of this work, we investigate the association of genetic variants (copy number variations [CNVs] and single nucleotide polymorphisms [SNPs]) with radiation induced rectal bleeding (RB) and erectile dysfunction (ED) while taking into account dosimetric and clinical variables in prostate cancer patients treated with curative irradiation. Methods: A cohort of 62 prostate cancer patients who underwent hypofractionated radiotherapy (66 Gy in 22 fractions) was retrospectively genotyped for CNV and SNP rs25489 in the xrcc1 DNA repair gene. Dosevolume metrics were extracted from treatment plans of 54 patients who had complete dosimetric profiles. Treatment outcomes were considered to be a Result of functional mapping of radiogenomic input variables according to a logit transformation. Model orders were estimated using resampling by leave-one out cross-validation (LOO-CV). Radiogenomic model performance was evaluated using area under the ROC curve (AUC) and LOO-CV. For continuous univariate dosimetric and clinical variables, Spearmans rank coefficients were calculated and p-values reported accordingly. In the case of binary variables, Chi-squared statistics and contingency table calculations were used. Results: Ten patients were found to have three copies of xrcc1 CNV (RB: χ2=14.6 [p<0.001] and ED: χ2=4.88[p=0.0272]) and twelve had heterozygous rs25489 SNP (RB: χ2=0.278[p=0.599] and ED: χ2=0.112[p=0.732]). LOO-CV identified penile bulb D60 as the only significant QUANTEC predictor (rs=0.312 [p=0.0145]) for ED. Radiogenomic modeling yielded statistically significant, cross-validated NTCP models for RB (rs=0.243[p=0.0443], AUC=0.665) and ED (rs=0.276[p=0

WE-AB-202-08: Feasibility of Single-Inhalation/Single-Energy Xenon CT for High-Resolution Imaging of Regional Lung Ventilation in Humans

Energy Technology Data Exchange (ETDEWEB)

Pinkham, D; Schueler, E; Diehn, M; Mittra, E; Loo, B; Maxim, P [Stanford University School of Medicine, Palo Alto, California (United States); Negahdar, M [IBM Research Center, San Jose, California (United States); Yamamoto, T [University of California Davis Medical Center, Sacramento, CA (United States)

2016-06-15

quantify regional lung ventilation volumetrically with high resolution using widely accessible radiologic equipment. Bill Loo and Peter Maxim are founders of TibaRay, Inc. Bill Loo is also a board member. Bill Loo and Peter Maxim have received research grants from Varian Medical Systems, Inc. and RaySearch Laboratory.

Advanced Concepts for Composite Structure Joints and Attachment Fittings. Volume 2. Design Guide

Science.gov (United States)

1981-11-01

500 3CC000 .loo 310- GRID 11040 100 M250 30.0000 .0 3311- GRID 11041 100 .2OO 15.COCO .5000 332- GRID 13042 ILO .2500 15.0000 .4000 313- GRID 11043...b~ l ( 115K -. 1 2 It e l t 1 1 A N A I 1 1 CARO 1 L~uNI 4 ... * ’ * 9.. 6 . p. . . 0 h0t- 91’ S 193 1001% 109 1016 402- SPl 9 123 10004 10006

Geographical Tatoos

OpenAIRE

Valéria Cazetta

2014-01-01

The article deals with maps tattooed on bodies. My interest in studying the corporeality is inserted in a broader project entitled Geographies and (in) Bodies. There is several published research on tattoos, but none in particular about tattooed maps. However some of these works interested me because they present important discussions in contemporary about body modification that helped me locate the body modifications most within the culture than on the nature. At this time, I loo...

Establish and Evaluate Ada Runtime Features of Interest for Real-Time Systems

Science.gov (United States)

1989-02-15

Runtime Features of Interest for Real - Time Systems -,-. CLEARED POR :)E,4 pUEL tCATLON SEP 2 0 19E19 ,CETM ORP t ’R RE LOO O Nt-U~HM- ANDQ SECURITY...ESTABLISH AND EVALUATE py ADA RUNTIME FEATURES OF INTEREST FOR REAL - TIME SYSTEMS CONTRACT NUMBER: MDA 903-87-D-0056 IITRI PROJECT NUMBER: T06168 PREPARED...2 2.0 SELECTION PROCESS OVERVIEW .................................... 3 2.1 REAL - TIME SYSTEMS IDENTIFICATION ........................... 4 2.2

Adult Learning and the Establishment of Training Programs in Bureaucratic-Like Organizations

Science.gov (United States)

1986-05-01

environment, and provide the methodology and resources required. 3. Product Use Training for Customers at DuPont ( Green , 8 1-85) When Du Pont developed a...contains pedorniance.-relate(, lot behavors that foremen, their supervsors and their subordinates have reported) as critcal ’to the foreman S job success...Please consider the above-named individual s behavior on the loo for the past three months Do not ccnsider other foremen or tlOs rnuividua;’s behavor at

Le ministre italien de la science inaugure une exposition industrielle au CERN

CERN Multimedia

CERN Press Office. Geneva

1993-01-01

On 30 November 1993 His Excellency Professor Umberto Colombo, Italy's Minister for Universities and Research opened the sixth "Italy at CERN" exhibition. The Minister was accompanied by His Excellency the Ambassador Giulio di Lorenzo Badia, Permanent Representative of Italy to the International Organizations in Geneva. CERN's Director-General, Prof. Carlo Rubbia welcomed the Minister and expressed his pleasure at the extremely wide range and high quality of the equipment on display at the exhibition.

Ministr obrazovanija : Russkomu obrazovaniju nitshto ne ugrazhajet / Tõnis Lukas ; interv. Jana Litvinova

Index Scriptorium Estoniae

Lukas, Tõnis, 1962-

2007-01-01

Haridus- ja teadusminister Tõnis Lukas vastab küsimustele, mis puudutavad hariduse finantseerimist, õpetajate kvalifikatsiooni, vene koolide reforme ja kohustusliku kirjanduse hulka mittesobivaid raamatuid

Prezident, spiker parlamenta i premjer-ministr võstupili s jedinõm zajavlenijem

Index Scriptorium Estoniae

2002-01-01

Presidendi, peaministri ja Riigikogu spiikri ühisavaldusest, milles kutsutakse rahvast üles hääletama Euroopa Liitu astumise poolt. Pealk. ajalehes Severnoje Poberezhje (2002/Dec/17) lk. 3: "Rukovodstvo stranõ prizõvajet ljudei golosovat za ES"

Synthetic Aperture Processing of Wideband Scattering Measurements Made in the DRDC Atlantic Acoustic Calibration Tank

Science.gov (United States)

2008-09-01

as represented by the Minister of National Defence, 2008 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la...des mines ventouses d’entraînement réelles, sur un disque de un mètre de diamètre qui était suspendu dans le bassin d’étalonnage acoustique de RDDC...Atlantique à l’aide d’une perche rotative. Deux disques ont été examinés : un en aluminium et l’autre en fibre de verre . Ces disques ont été tournés

Gilles Pérez, Gilles Rof, Les rebelles du Foot

OpenAIRE

Banaré, Eddy

2012-01-01

Le lien entre sport et politique n’est pas nouveau en soi : les déclarations de Mohamed Ali contre la guerre du Vietnam ou le poing ganté brandi par Tommie Smith et John Carlos aux Jeux Olympiques de Mexico en 1968 sont emblématiques. En quoi le football diffère-t-il ? Qu’il y a-t-il de nouveau dans Les rebelles du foot? Le foot semble, au premier abord, plus facilement instrumentalisé par la politique : les tribunes de stades servent parfois de vitrines aux candidats, ministres ou présidents...

The environment of the Slovak Republic; Zivotne prostredie Slovenskej republiky

Energy Technology Data Exchange (ETDEWEB)

Klinda, J; Brechtl, J; Havlikova, J; Herdova, V; Klindova, A; Kmitova, V; Lacikova, D; Lacova, L; Lieskovska, Z; Mrva, I; Plesnikova, T; Sestakova, Z; Toma, P; Vilinovic, K [Ministry of the Environment of the Slovak Republic, Nam. L. Stura 1, 812 35 Bratislava (Slovakia)

1999-07-01

This report of the Ministry of the Environment of the Slovak Republic deals with next areas of the environment of the Slovak Republic in 1999: (1) Basic information about the Slovak republic; (2) The environmental protection; (3) The cultural monuments protection; (4) The world and natural heritage; (5) The biodiversity; (6) The territorial system of ecological stability; (7) The environmental regional partition; (8) Components of the environment and their protection; (9) Environmental risk factors (radiation and others); (10) Health and age of population; (11) Ministration on environment; (12 ) International co-operation. Alphabetical list of abbreviations and texts to pictures are included.

'Pflanze, Otto, Bismarck'

OpenAIRE

Burgaud, Stéphanie

2013-01-01

La somme que l’historien américain O.P. consacra au ministre prussien puis chancelier d’Empire, Otto von Bismarck, parut en 1990, fruit de plusieurs décennies de travail. Traduite en allemand en 1997 chez Beck, elle connut un immense succès académique. La posture de l’auteur, en retrait des débats historiographiques sur le Sonderweg, son impartialité affichée, et surtout l’analyse équilibrée qu’il menait entre période prussienne et impériale (particulièrement lisible dans la version allemande...

The environment of the Slovak Republic

International Nuclear Information System (INIS)

Klinda, J.; Brechtl, J.; Havlikova, J.; Herdova, V.; Klindova, A.; Kmitova, V.; Lacikova, D.; Lacova, L.; Lieskovska, Z.; Mrva, I.; Plesnikova, T.; Sestakova, Z.; Toma, P.; Vilinovic, K.

1999-01-01

This report of the Ministry of the Environment of the Slovak Republic deals with next areas of the environment of the Slovak Republic in 1999: (1) Basic information about the Slovak republic; (2) The environmental protection; (3) The cultural monuments protection; (4) The world and natural heritage; (5) The biodiversity; (6) The territorial system of ecological stability; (7) The environmental regional partition; (8) Components of the environment and their protection; (9) Environmental risk factors (radiation and others); (10) Health and age of population; (11) Ministration on environment; (12 ) International co-operation. Alphabetical list of abbreviations and texts to pictures are included

Eesti läheb Pekingisse / Karin Hallas-Murula

Index Scriptorium Estoniae

Hallas-Murula, Karin, 1957-

2008-01-01

Pekingi Eesti saatkonnahoone konkursist žüriiliikme pilguga. Premeeritud ja esiletõstetud töödest. Võidutöö autorid - Lauri Vaimel, Andres Põime, Liisa Põime; II koht - Erik Nobel ja Nobel Arkitekten, Taani-Eesti; III koht - Kalle Vellevoog, Velle Kadalipp, Tiiu Truus, Martin Prommik; ostudega esiletõstetud tööde autorid - Priit Pent ja Raul Järg Bucoma OÜ-st ning Jan Skolimowski, Peeter Loo, Kaspar Kruuse ja Li Vene KAMP Arhitektide OÜ-st. Hiina ja Pekingi uusehitistest, arhitektidest

Programme to encourage the development of fine motor skills with a girl with developmental delay

OpenAIRE

Ivančič, Urška

2017-01-01

Movement plays an important role in the integral development of a child. Good motor skills facilitate learning and thus they consequently have a positive impact on improved learning success. The theoretical part presents the importance and role of gross motor skills and its relationship to the development of fine motor skills. More specifically, we have focused on the following: the course of development of fine motor skills, the impact fine motor skills have on the child and we have also loo...

Bursting Smoke as an Infrared Countermeasure

OpenAIRE

Amarjit Singh; P. J. Kamale; S. A. Joshi; L. K. Bankar

1998-01-01

This paper describes the experimental setup for the evaluation of bursting smoke for anti-infrared role using SR-5000 spectroradiometer and a source of IR radiation (8-13 micrometer) using cadmium-mercury-telluride (CMI) detector cooled by liquid nitrogen. The particle size and shape of the powders used in the bursting smokes were determined microscopically using Carl Zeiss Jena Neophot- 21. Highest attenuation of 97 -lOO percent was produced for about 12 s using a mixture of bronze fl...

Evaluation of Integrated Training Prototype 94B10, Fort Jackson, South Carolina.

Science.gov (United States)

1981-03-01

instructor! and all thraa cadro indicatad that thay would volunteer to sarva if tha saaw coura« wara offarrad again. Thraa instructor...indicatad that thay would not volunteer . sased on all responses, thoaa atoova and othars. sis instructors and ona cadra did gain a...rstod at too loo* ovoroll on »too1 «t tnn ooslrod loool of 1_ 1.2.2 Datail: TIM cadra BMbcri1 poa »0 totMr ahm» or bahavior » la «11

EDGE TECHNOLOGIES IN IoT AND APPLICATION SCENARIO OF RFID BASED IoT

OpenAIRE

Dharam Gami *, Asst. Prof. Dhaval Nimavat, Asst. Prof. Shubham Sharma

2016-01-01

Internet of Things possesses the power to change the era. IoT will offer an advance connectivity between objects which will change the face of machine-to-machine communication. IoT will connect autonomous systems, devices and heterogeneous machines and make them communicate without human interactions. Many technologies will play significant role in IoT implementation. In this paper, we aim to describe the candidate of edge technologies in IoT and demonstrate how RFID based IoT system will loo...

The Development of Nonstructural Alternatives.

Science.gov (United States)

1979-05-01

particular appeal and benefits for those concerned with environmental issues. However, on reflection it is clear that, almost by definition, easily...peculiar to nonstructural alternatives (that is, the social costs are borne primaqrilv by th,, )ent ficiaries) makes them appealing from the national...Costs Of prId-nt ! loo41p l jotve iopment lie basically in the costs of elevated 111’Z ’’l’i. Pie 1land reqat reti c,- snob dovelIopmeot is loss

How Customers and Employees of Perceptive Informatics Feel about Software as A Service Deployment Model and What Are the Barriers They Feel that Exist towards Adoption of the Model?

OpenAIRE

Panneerselvam, Arunkumar

2012-01-01

Software-as-a-Service deployment model has become the way forward for many technology companies. Most companies with an established on-premise business are looking to adopt SaaS deployment model to incorporate SaaS offerings into their product portfolio. Gartner (2012) expects the SaaS enterprise application market to grow from $11.8 billion in 2012 to $26.5billion in 2016 generating a 17.4% compound annual growth rate. Perceptive Informatics is a leading eClinical solutions provider, loo...

Monitoring cure of composite resins using frequency dependent electromagnetic sensing techniques

Science.gov (United States)

Kranbuehl, D. E.; Hoff, M. S.; Loos, A. C.; Freeman, W. T., Jr.; Eichinger, D. A.

1988-01-01

A nondestructive in situ measurement technique has been developed for monitoring and measuring the cure processing properties of composite resins. Frequency dependent electromagnetic sensors (FDEMS) were used to directly measure resin viscosity during cure. The effects of the cure cycle and resin aging on the viscosity during cure were investigated using the sensor. Viscosity measurements obtained using the sensor are compared with the viscosities calculated by the Loos-Springer cure process model. Good overall agreement was obtained except for the aged resin samples.

Arlecchino räägib legendaarse võrgutaja tõelise loo / Anneli Sihvart

Index Scriptorium Estoniae

Sihvart, Anneli, 1964-

2011-01-01

Itaalia maskiteatri Pantakin Company etendus "L'Arlecchino don Giovanni" veekarnevalil Admiraliteedi basseini juures 17. juulil 2011. Pantakin Company'st, mis loodi Veneetsias 1995. a., hoidmaks elavana commedia dell'aete ja maskiteatri traditsioone

Hearing of Francois Loos, ministry delegated to the Industry, on the electricity tariffs

International Nuclear Information System (INIS)

2007-01-01

The ministry answers questions relative to the electricity price: the position of the tariffs in Europe, the tariffs for the industry, the margins, EDF, the energy policy and the part of the nuclear, the fight against the CO 2 . (A.L.B.)

Yerli ve Yabancı Kökenli Bazı Zeytinyağlarının Trigliserit Düzeylerine Göre Kemometrik Sınıflandırılması

Directory of Open Access Journals (Sweden)

Harun Dıraman

2015-02-01

Full Text Available Bu çalışmada Türkiye’den (2 KKTC, 2 Güneydoğu Anadolu, 3 Akdeniz, 9 Kuzey Ege, 3 İzmir Yarımdası, 16 Güney Ege, 11 Akhisar-Manisa, 4 Marmara ve diğer ülkelerden (1 Ürdün, 1 Filistin, 3 İspanya,1 Portekiz, 2 İtalya, 2 Yunanistan olmak üzere toplam 60 adet ticari natürel zeytinyağı örneği, kemometrik yöntemler (Temel Bileşenler [PCA] Kümeleme [HCA] analizleri yardımıyla triaçilgliserol (TAG bileşenlerine göre sınıflandırılmış ve karakterize edilmişlerdir. Yağ örneklerinin TAG profilleri (ECN 42–ECN 50,LLL ve ana bileşenleri LOO, OOO, POO, PLO ve SOO Avrupa Komisyonu (ABK tarafından onaylanmış Yüksek Basınç Sıvı Kromatografisi ile belirlenmiştir. Türk natürel zeytinyağlarının TAG bileşenlerinin diğer zeytinyağı üreten ülkelerin ürünleri ile benzer olduğu ve bir örnek hariç (Filistin analiz edilen tüm yağ örneklerindeki trilinolein (LLL düzeylerinin, ABK tarafından farklı zeytinyağları için verilen en çok %0.5 düzeyini aşmadığı görülmüştür. Kümeleme analizi (HCA sonuçlarına göre, Türk ve yabancı zeytinyağı örnekleri sırasıyla beş gruba ayrılmıştır. Temel bileşenler analizine (PCA göre, Güney Ege (hâkim çeşit Memecik yağ örneklerinin sınıflandırılmasında LOO/POO, OOO/POO ve OOO düzeylerinin sorumlu olduğu gözlenmiştir. Kuzey Ege (hâkim çeşit Ayvalık örneklerinin ayrımında LOO parametresi büyük rol oynamıştır. Akhisar–Manisa yöresi örnekleri ise ECN48 ve ECN48/ECN46 parametreleri ile karakterize olmuştur. Bu çalışmada Türkiye’den (2 KKTC, 2 Güneydoğu Anadolu, 3 Akdeniz, 9 Kuzey Ege, 3 İzmir Yarımdası, 16 Güney Ege, 11 Akhisar-Manisa, 4 Marmara ve diğer ülkelerden (1 Ürdün, 1 Filistin, 3 İspanya,1 Portekiz, 2 İtalya, 2 Yunanistan olmak üzere toplam 60 adet ticari natürel zeytinyağı örneği, kemometrik yöntemler (Temel Bileşenler [PCA] Kümeleme [HCA] analizleri yardımıyla tria

Présentation

OpenAIRE

Le Bart, Christian; Lefebvre, Rémi

2008-01-01

Le succès rencontré par un mot ou une expression constitue toujours un mystère. Nous ne sommes ici pas les premiers à nous étonner des usages de plus en plus fréquents, dans le langage sociopolitique, du terme de « proximité ». Il prend désormais place dans les désignations les plus solennelles : démocratie de proximité, justice de proximité, police de proximité, et finalement République des proximités. Qui plus est, c’est dans la bouche d’un Premier ministre (Jean-Pierre Raffarin), et sous s...

Emergencies and emergency planning in France

International Nuclear Information System (INIS)

Jammet, H.

1986-01-01

The organization for dealing with radiation emergencies in France is complex and centralized. It consists of the Radiation Security Council with participants from the Premier Ministre and the Ministers of Interior, Industry, Health, and Defense. A permanent general secretary for radiation security coordinates the work of the various departments. Planning for nuclear power emergencies is divided between on-site, in which organization and intervention are the responsibilities of the manager of the plant, and off-site, in which organization and intervention are the responsibility of the regional governor. Both on-site and off-site planning have models integrated into a special code of practice called the radiation emergency organization

Du bon maniement de l’argent du roi en Espagne au XVIIIe siècle. Les enseignements d’un procès pour fraude

Directory of Open Access Journals (Sweden)

Anne Dubet

2010-07-01

Full Text Available Pour nombre d’historiens – dont je fais partie – les réformes financières entreprises par les premiers Bourbons d’Espagne au XVIIIe siècle n’affectent pas tant l’organisation fiscale de leurs territoires que leur administration. Avant que de modifier la répartition sociale des contributions, il s’agit de rendre au roi et à ses ministres de confiance la décision en matière de dépenses et de s’assurer de son exécution. Ce projet de contrôle accru du roi sur ses propres deniers se traduit certes...

Rupert Murdoch＇ s Leadership

Institute of Scientific and Technical Information of China (English)

Lian Hohuizi

2011-01-01

Rupert Murdoch, a legendary mogul who has long been listed as one of the most influential people in the world, leads and processes the second - largest media empire in the world. With forty years of con- tinuous effort, he exhibits exceptional business sense and superb ad- ministrative capabilities in the media industry. He moves quickly in ex- panding his business and adopts unique management approach to lead followers. By exploring his background and experience, this paper will detect his unique traits and leadership behaviors that underlie his suc- cessful achievement in leading News Corporation, and how can his leadership style be applied to hospitality industry.

Le pardon et la « Commission Vérité et Réconciliation » Forgiveness and the “Truth Reconciliation Commission”

Directory of Open Access Journals (Sweden)

Gérard Courtois

2009-07-01

Full Text Available Dans le domaine géo-politique on voit se multiplier les scènes de repentir, de reconnaissance de fautes, de pardon, d’excuses. Parmi tant d’autres : l’Eglise de France a demandé pardon pour l’antisémitisme qui a accompagné son histoire séculaire, on attend de la Cinquième République qu’elle reconnaisse « pleinement » les méfaits de son passé esclavagiste, le premier ministre du Japon a demandé pardon (en son nom personnel pour l’instant aux Coréens et au Chinois pour les violences impériales...

The population structure of Glossina palpalis gambiensis from island and continental locations in Coastal Guinea.

Directory of Open Access Journals (Sweden)

Philippe Solano

Full Text Available We undertook a population genetics analysis of the tsetse fly Glossina palpalis gambiensis, a major vector of sleeping sickness in West Africa, using microsatellite and mitochondrial DNA markers. Our aims were to estimate effective population size and the degree of isolation between coastal sites on the mainland of Guinea and Loos Islands. The sampling locations encompassed Dubréka, the area with the highest Human African Trypanosomosis (HAT prevalence in West Africa, mangrove and savannah sites on the mainland, and two islands, Fotoba and Kassa, within the Loos archipelago. These data are discussed with respect to the feasibility and sustainability of control strategies in those sites currently experiencing, or at risk of, sleeping sickness.We found very low migration rates between sites except between those sampled around the Dubréka area that seems to contain a widely dispersed and panmictic population. In the Kassa island samples, various effective population size estimates all converged on surprisingly small values (10

Heterogeneous fenton degradation of azo dyes catalyzed by modified polyacrylonitrile fiber fe complexes: QSPR (quantitative structure peorperty relationship) study.

Science.gov (United States)

Li, Bing; Dong, Yongchun; Ding, Zhizhong

2013-07-01

The amidoximated polyacrylonitrile (PAN) fiber Fe complexes were prepared and used as the heterogeneous Fenton catalysts for the degradation of 28 anionic water soluble azo dyes in water under visible irradiation. The multiple linear regression (MLR) method was employed to develop the quantitative structure property relationship (QSPR) model equations for the decoloration and mineralization of azo dyes. Moreover, the predictive ability of the QSPR model equations was assessed using Leave-one-out (LOO) and cross-validation (CV) methods. Additionally, the effect of Fe content of catalyst and the sodium chloride in water on QSPR model equations were also investigated. The results indicated that the heterogeneous photo-Fenton degradation of the azo dyes with different structures was conducted in the presence of the amidoximated PAN fiber Fe complex. The QSPR model equations for the dye decoloration and mineralization were successfully developed using MLR technique. MW/S (molecular weight divided by the number of sulphonate groups) and NN=N (the number of azo linkage) are considered as the most important determining factor for the dye degradation and mineralization, and there is a significant negative correlation between MW/S or NN=N and degradation percentage or total organic carbon (TOC) removal. Moreover, LOO and CV analysis suggested that the obtained QSPR model equations have the better prediction ability. The variation in Fe content of catalyst and the addition of sodium chloride did not alter the nature of the QSPR model equations.

Simulation of the induction of oxidation of low-density lipoprotein by high copper concentrations: evidence for a nonconstant rate of initiation.

Science.gov (United States)

Abuja, P M; Albertini, R; Esterbauer, H

1997-06-01

Kinetic simulation can help obtain deeper insight into the molecular mechanisms of complex processes, such as lipid peroxidation (LPO) in low-density lipoprotein (LDL). We have previously set up a single-compartment model of this process, initiating with radicals generated externally at a constant rate to show the interplay of radical scavenging and chain propagation. Here we focus on the initiating events, substituting constant rate of initiation (Ri) by redox cycling of Cu2+ and Cu+. Our simulation reveals that early events in copper-mediated LDL oxidation include (1) the reduction of Cu2+ by tocopherol (TocOH) which generates tocopheroxyl radical (TocO.), (2) the fate of TocO. which either is recycled or recombines with lipid peroxyl radical (LOO.), and (3) the reoxidation of Cu+ by lipid hydroperoxide which results in alkoxyl radical (LO.) formation. So TocO., LOO., and LO. can be regarded as primordial radicals, and the sum of their formation rates is the total rate of initiation, Ri. As experimental information of these initiating events cannot be obtained experimentally, the whole model was validated experimentally by comparison of LDL oxidation in the presence and absence of bathocuproine as predicted by simulation. Simulation predicts that Ri decreases by 2 orders of magnitude during lag time. This has important consequences for the estimation of oxidation resistance in copper-mediated LDL oxidation: after consumption of tocopherol, even small amounts of antioxidants may prolong the lag phase for a considerable time.

Comparison of Extreme Precipitation Return Levels using Spatial Bayesian Hierarchical Modeling versus Regional Frequency Analysis

Science.gov (United States)

Love, C. A.; Skahill, B. E.; AghaKouchak, A.; Karlovits, G. S.; England, J. F.; Duren, A. M.

2017-12-01

We compare gridded extreme precipitation return levels obtained using spatial Bayesian hierarchical modeling (BHM) with their respective counterparts from a traditional regional frequency analysis (RFA) using the same set of extreme precipitation data. Our study area is the 11,478 square mile Willamette River basin (WRB) located in northwestern Oregon, a major tributary of the Columbia River whose 187 miles long main stem, the Willamette River, flows northward between the Coastal and Cascade Ranges. The WRB contains approximately two ­thirds of Oregon's population and 20 of the 25 most populous cities in the state. The U.S. Army Corps of Engineers (USACE) Portland District operates thirteen dams and extreme precipitation estimates are required to support risk­ informed hydrologic analyses as part of the USACE Dam Safety Program. Our intent is to profile for the USACE an alternate methodology to an RFA that was developed in 2008 due to the lack of an official NOAA Atlas 14 update for the state of Oregon. We analyze 24-hour annual precipitation maxima data for the WRB utilizing the spatial BHM R package "spatial.gev.bma", which has been shown to be efficient in developing coherent maps of extreme precipitation by return level. Our BHM modeling analysis involved application of leave-one-out cross validation (LOO-CV), which not only supported model selection but also a comprehensive assessment of location specific model performance. The LOO-CV results will provide a basis for the BHM RFA comparison.

Official Guard and Reserve Manpower Strengths and Statistics. FY 2005 Summary

Science.gov (United States)

2005-01-01

Comments concerned with policy issues of use of these reports for Reserve Component studies should be addressed to the Office of the Assistant...r~ln^ooN^co^J^OHlrlH(\\l(^loo^(Ti^oDHoo’TVlO^^^^(D^^^^o^^ ininoohViOraimooiniohcoHCN^^ CNCD ^inin’ririinin^^HOH^’a’tNinooo^u) r^r^oocxsi^vD^ixi...Ld H S s o EH EH H APPENDIX A DISTRIBUTION AGENCIES COPIES DEPARTMENT OF DEFENSE OSD (MM&PP) (AP) 1 OASD (RA) RESERVE FORCES POLICY BOARD 5

European Law in the Making:

DEFF Research Database (Denmark)

Rasmussen, Morten

Traditionally, the Court of Justice of the European Coal and Steel Community (ECSC) has mainly been considered the somewhat dull predecessor to the more famous Court of Justice of the European Communities, which in 1963-64 ‘constitutionalised’ the Treaties of Rome with the seminal judgments of Van...... Gend en Loos and Costa V. ENEL. The jurisprudence of the Court of Justice of the ECSC was allegedly conservative dominated by technical and economic considerations less than adventurous activism. Recent historical research has demonstrated the complexity of the legal landscape of the 1950s, in which...

Comparison of L-curve and LOOCV depth profiles from TAARXPS data

Energy Technology Data Exchange (ETDEWEB)

Paynter, R.W., E-mail: royston_paynter@emt.inrs.ca

2017-01-15

Highlights: • Regularized profiles were extracted from TAARXPS data. • The L-curve and LOO cross-validation were used to choose the regularization parameter. • The two parameter choice methods were compared. - Abstract: Time and angle resolved X-ray photoelectron spectroscopy (TAARXPS) data, obtained from polystyrene samples exposed to an oxygen/helium plasma, have been interpreted using 1st order Tikhonov regularization to smooth the extracted depth profiles. Two methods for the choice of the regularization parameter, namely the L-curve method and leave-one-out cross-validation (LOOCV), are compared and contrasted.

La ministre Bibeau annonce la nomination du président du CRDI et ...

International Development Research Centre (IDRC) Digital Library (Canada)

il y a 5 jours ... ... et chargé de cours associé à l'Université Griffith de South East Queensland, en Australie. Ancien professeur adjoint auxiliaire à la School of International and Public Affairs de l'Université Columbia, à New York; et ancien chercheur du Centre international pour la recherche en agroforesterie, à Nairobi.

Vaata, ajakiri tellis loo... / Rünno Saaremäe, Üllar Saaremäe

Index Scriptorium Estoniae

Saaremäe, Rünno

2001-01-01

Lühimängufilm "Armas tuss 50 aastat hiljem" : stsenarist Peeter Sauter : režissöör René Vilbre : peaosades Lembit Eelmäe ja Herta Elviste : Allfilm 2000. Lisa : S. Teinemaa lisatud lühiandmed autorite ja R. Vilbre kohta

Aux origines de la police politique républicaine

Directory of Open Access Journals (Sweden)

Marie Vogel

2008-01-01

Full Text Available Le 30 juin 1880, alors que la République semble encore fragile et mal assurée, le directeur de la Sûreté générale adresse au ministre de l’Intérieur un rapport  qui tire les enseignements des actions récemment menées par ses services et expose ce que devraient être les missions, les pratiques et l’organisation d’une police politique républicaine qui reste encore à inventer. Ce texte, d’un grand intérêt pour qui veut connaître les méthodes, l’organisation d’une police à l’état embryonnaire, s’...

Ernest Beulé (1826-1874. Archéologie classique, histoire romaine et politique sous Napoléon III

Directory of Open Access Journals (Sweden)

Yves Billard

2012-02-01

Full Text Available Dans la nuit du 3 au 4 avril 1874, vers minuit, un homme qui fut l’un des pionniers de l’archéologie française en Grèce et que la politique avait fini par séduire au point de faire de lui un éphémère ministre de l’Intérieur se suicide chez lui, à Paris. Le geste par lequel Ernest Beulé met fin à ses jours est digne de l’Antique. Souffrant depuis quelques semaines d’une douloureuse maladie au cœur, il saisit un poignard d’une panoplie qui ornait sa chambre et se l’enfonce dans la poitrine. Il ...

Chapitre XIII. Lord Kitchener

OpenAIRE

Abbas Hilmi II,

2017-01-01

Son caractère. Famille. Carrière au Foreign-Office. Carrière administrative en Egypte. Ministre plénipotentiaire. Mariage. Mort. Action bénéfique en Egypte. Les Égyptiens ne l’ont pas apprécié à sa juste valeur. C’est tout au début de sa carrière politique que Sir Eldon Gorst est arrivé en Égypte où il avait été nommé Sous-Secrétaire d’État au Ministère des Finances. Tout le monde s’étonna qu’un homme aussi jeune ait pu être désigné pour occuper une fonction aussi importante. Sa formation de ...

Tõhusad tükid teismeliste poiste raamaturiiulis / Aidi Vallik

Index Scriptorium Estoniae

Vallik, Aidi, 1971-

2007-01-01

Tutvustus: Townsend, Sue. Salajane päevik. Tallinn : Tänapäev, 2002 ; Jacobsson, Anders, Olsson, Sören. Emanuel. Tallinn : Hotger, 2002 ; Brennan, Herbie. Haldjasõjad. Tallinn : Varrak, 2005 ; Paolini, Christopher. Eragon. Tallinn : Pegasus, 2005 ; Paolini, Christopher. Vanem. Tallinn : Pegasus, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Tartu : Lugu-Loo, 2006 ; Schlüter, Andreas. Laste linn. Tallinn : Tormikiri, 2005 ; Schlüter, Andreas. Rööv. Tallinn : Tormikiri, 2005 ; Sachar, Lois. Augud. Tallinn : Draakon ja Kuu, 2005 ; Rannap, Jaan. Roheline kindlus. Tartu : Tiritamm, 2006 ; Henno, Sass. Mina olin siin. Tallinn : Eesti Päevalehe Kirjastus, 2005

‘Die choreografie van ontwyking’: Die poëtiese krag van negativering by Elisabeth Eybers

Directory of Open Access Journals (Sweden)

Hein Viljoen

2014-12-01

Full Text Available ‘The choreography of evasion’: The poetical power of negation in the work of Elisabeth Eybers. This article is an exploration of the striking use of words with the prefixes on- and ont-,as well as other negatives, markers of negation or terms and affixes of deprivation, like sonder,-loos, etcetera, in Elisabeth Eybers’s poetry. It is a hermeneutic investigation into the possibilities of expression offered by negation and the role they play in her poetry and poetic conception. Eybers often creates an alternative world by means of negation. This is typical of her poetics and poetical stance.

Thermionic phenomena the collected works of Irving Langmuir

CERN Document Server

Suits, C Guy

1961-01-01

Thermionic Phenomena is the third volume of the series entitled The Collected Works of Irving Langmuir. This volume compiles articles written during the 1920's and early 1930's, the period when the science of thermionics is beginning to be of importance. This text is divided into two parts. The first part discusses vacuum pumps, specifically examining the effect of space charge and residual gases on thermionic currents in high vacuum. This part also explains fundamental phenomena in electron tubes having tungsten cathodes and the use of high-power vacuum tubes. The second part of this text loo

Shelf Stable Epoxy Repair Adhesive

Science.gov (United States)

2015-02-01

FINAL REPORT formulations chosen: KC-PDDACL, IC-PDDACL, gelatin-KC-PDDACL and gelatin-gum arabic . The capsules were 10-25 µm in size. Analysis...as a means to make microcapsules for carbonless paper. A schematic of a typical complex coacervation process, using gelatin and gum arabic , can be...r U~001na C~1’d lOO~ T~.:S:J.f.~:1 ~~ nlp !o GundtiiC",ulg T ~·1 (’;,nd :~n. SniT’ple Niirr fo: P1404.SLS.Jl46.FE.N P1404.SL$.047.FE.I’I

Edvard Beneš jako ministr zahraničních věcí

OpenAIRE

Souček, Martin

2012-01-01

Bachelor thesis deals with person Edvard Beneš as the czechoslovak Foreign Minister during the period 1918-1935. His life, studies, resistance activity and the participation in Paris Peace Conference are captured in the first part of the thesis. The most important events in post-war Europe and relations with neighboring countries, Vatican, Italy, SSSR and allies in the twenties are outlined in the second part of the thesis. Third part is concetrated on Beneš's foreign policy in the period of ...

Quest for professionalism: a biography of the North American Medical and Surgical Journal (1826-31).

Science.gov (United States)

Shultz, S M

2011-08-01

This is the biography of a deceased medical journal, the North American Medical and Surgical Journal, born in 1826 in Philadelphia. It was a publication of the Philadelphia Chapter of the Kappa Lambda Society. In the prospectus of the North American Medical and Surgical Journal the promoters observed that a well-conducted journal would achieve the object of elevating the medical profession to its legitimate rank which up to that time had been the recipient of low public opinion. The Journal hoped to inculcate 'a higher standard of excellence not merely in the professional or ministrative but also in the ethical relations and duties of physicians'. After several successful and productive years it passed into history in October 1831, the victim of financial difficulty.

Filmiööd on kohal / Kaisa Karu, Egle Loo, Jüri Laulik, Jaanus Noormets

Index Scriptorium Estoniae

Karu, Kaisa

2009-01-01

13. Pimedate Ööde Filmifestival: huvitavamaid filme võistlusprogrammist EurAsia, programmidest Panoraam, Foorum, Ladina-Ameerika, 13 valitud teost, Ööfilmid, Screen kriitikute valik, Põhja Valgus

Proteomic biomarkers predicting lymph node involvement in serum of cervical cancer patients. Limitations of SELDI-TOF MS

Directory of Open Access Journals (Sweden)

Van Gorp Toon

2012-06-01

Full Text Available Abstract Background Lymph node status is not part of the staging system for cervical cancer, but provides important information for prognosis and treatment. We investigated whether lymph node status can be predicted with proteomic profiling. Material & methods Serum samples of 60 cervical cancer patients (FIGO I/II were obtained before primary treatment. Samples were run through a HPLC depletion column, eliminating the 14 most abundant proteins ubiquitously present in serum. Unbound fractions were concentrated with spin filters. Fractions were spotted onto CM10 and IMAC30 surfaces and analyzed with surface-enhanced laser desorption time of flight (SELDI-TOF mass spectrometry (MS. Unsupervised peak detection and peak clustering was performed using MASDA software. Leave-one-out (LOO validation for weighted Least Squares Support Vector Machines (LSSVM was used for prediction of lymph node involvement. Other outcomes were histological type, lymphvascular space involvement (LVSI and recurrent disease. Results LSSVM models were able to determine LN status with a LOO area under the receiver operating characteristics curve (AUC of 0.95, based on peaks with m/z values 2,698.9, 3,953.2, and 15,254.8. Furthermore, we were able to predict LVSI (AUC 0.81, to predict recurrence (AUC 0.92, and to differentiate between squamous carcinomas and adenocarcinomas (AUC 0.88, between squamous and adenosquamous carcinomas (AUC 0.85, and between adenocarcinomas and adenosquamous carcinomas (AUC 0.94. Conclusions Potential markers related with lymph node involvement were detected, and protein/peptide profiling support differentiation between various subtypes of cervical cancer. However, identification of the potential biomarkers was hampered by the technical limitations of SELDI-TOF MS.

Development of an environment for 3D visualization of riser dynamics

Energy Technology Data Exchange (ETDEWEB)

Bernardes Junior, Joao Luiz; Martins, Clovis de Arruda [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica]. E-mails: joao.bernardes@poli.usp.br; cmartins@usp.br

2006-07-01

This paper describes the merging of Virtual Reality and Scientific Visualization techniques in the development of Riser View, a multi platform 3D environment for real time, interactive visualization of riser dynamics. Its features, architecture, unusual collision detection algorithm and how up was customized for the project are discussed. Using Open GL through VRK, the software is able to make use of the resources available in most modern Graphics. Acceleration Hardware to improve performance. IUP/LED allows for native loo-and-feel in MS-Windows or Linux platform. The paper discusses conflicts that arise between scientific visualization and aspects such as realism and immersion, and how the visualization is prioritized. (author)

Recovery of primary cassiterite by flotation

International Nuclear Information System (INIS)

Oliveira, J.F. de; Penna, M.T.M.; Adamian, R.

1985-01-01

The flotation of cassiterite ores using samples of primary ore from Pela Ema, Brazil is studied. The cassiterite was characterized by X-ray fluorescence analysis. The samples were submitted to size reduction up ro minus loo m in order to obtain liberation of cassiterite in excess of 95%. The flotation tests were carried out without desliming. Several collectors and depressants were investigated, as well as the influence of the concentration of these reactants and the pH factor upon flotation of cassiterite. The results were analysed considering the flotability of the minerals, and the electrophoretic mobility of cassiterite, both in the presence and absence of selected collectors. (Author) [pt

Benaderings tot die interpretasie van die wonderverhale in Markus 8-10

Directory of Open Access Journals (Sweden)

G. J. van Wyk

2009-07-01

Full Text Available Approaches to the interpretation of miracle stories in Mark 8-10 Research on the miracle stories in Mark 8-10 and their role in this Gospel is discussed. The mythological, religious-historical, form-historical, Biblical-theological, redaction-historical, socio- logical, literary-critical, the research of Van der Loos and Brown, salvation-historical and revelation-historical research are discussed. Research shows that the kingdom of God, a paradoxal Christology and discipleship play an important role in the miracles and miracle stories in the Gospel of Mark. Miracles form an integral part of the gospel and ministry of Jesus. They serve to support the teaching of Jesus.

The quantitative structure-insecticidal activity relationships from plant derived compounds against chikungunya and zika Aedes aegypti (Diptera:Culicidae) vector.

Science.gov (United States)

Saavedra, Laura M; Romanelli, Gustavo P; Rozo, Ciro E; Duchowicz, Pablo R

2018-01-01

The insecticidal activity of a series of 62 plant derived molecules against the chikungunya, dengue and zika vector, the Aedes aegypti (Diptera:Culicidae) mosquito, is subjected to a Quantitative Structure-Activity Relationships (QSAR) analysis. The Replacement Method (RM) variable subset selection technique based on Multivariable Linear Regression (MLR) proves to be successful for exploring 4885 molecular descriptors calculated with Dragon 6. The predictive capability of the obtained models is confirmed through an external test set of compounds, Leave-One-Out (LOO) cross-validation and Y-Randomization. The present study constitutes a first necessary computational step for designing less toxic insecticides. Copyright © 2017 Elsevier B.V. All rights reserved.

Insitu measurement and control of processing properties of composite resins in a production tool

Science.gov (United States)

Kranbuehl, D.; Hoff, M.; Haverty, P.; Loos, A.; Freeman, T.

1988-01-01

An in situ measuring technique for use in automated composite processing and quality control is discussed. Frequency dependent electromagnetic sensors are used to measure processing parameters at four ply positions inside a thick section 192-ply graphite-epoxy composite during cure in an 8 x 4 in. autoclave. Viscosity measurements obtained using the sensors are compared with the viscosities calculated using the Loos-Springer cure process model. Good overall agreement is obtained. In a subsequent autoclave run, the output from the four sensors was used to control the autoclave temperature. Using the 'closed loop' sensor controlled autoclave temperature resulted in a more uniform and more rapid cure cycle.

Cobalt-Free Permanent Magnet Alloys.

Science.gov (United States)

1984-10-01

ThC Ferrites (Zn, Mn. Cu, Fe)O A12O. Al TiC Kaolin Al203.Si02-Fe2O3 Fe2O3 Li B4C Spodumene LiAI (SiOs) 2 ThO2 Ni UC Rhodonite NtnO. SiO2 MnOs Fe TaC...minutes. X-ray diffraction pattern indicated the presence of magnetic T phase. Hysteresis loop was measured on the heat treated powder dispersed in wax...fmgei * T phse Hysersi loo was mesue on the. heat - treated ,--". " powder dispersed in wax... The’ result wer as"- follows: • , " • "• . I TABLE 6

Introduction – Confiance, reliance et apprentissage des langues dans l’enseignement supérieur

OpenAIRE

Rémon, Joséphine; Privas-Bréauté, Virginie

2018-01-01

Lors de sa conférence de presse du 29 août 2017 intitulée « L’école de la confiance », le nouveau ministre de l’Éducation nationale, Jean Michel Blanquer, proposait de « faire émerger l’école de la confiance »pour une société de la confiance et de favoriser « la confiance des élèves en eux-mêmes ». Il pointait en effet le manque de confiance en soi des apprenants français et notait que l’école de la confiance « ne se décrète pas ». Cette problématique se prolonge dans l’enseignement supérieur...

[Hydrogeology and medicine in the approach to health problems linked to nitrates: examples in Lorraine].

Science.gov (United States)

Melet, J J; Morlot, M; Passavy, J; Salado, J

1980-01-01

An investigation carried out by French Ministration of Agriculture (S.R.A.E.L.) has worked out an inventory and defined the nitrate amount evolution in waters, specially originated with underground formations, stared out by collectivities. The investigation spreading has brought about some ascertainment in Lorraine country. Particularly, the "Laboratoire d'hygiène et de recherche en santé publique" has so identified in a commune near Nancy, where nitrate amounts in water are particularly high, gastrointestinal troubles probably caused by minor methemoglobinemias which water supply origin have not been locally suspected. This note so shows that medical and paramedical corps cooperation with administrative authorities charged with water resource can attempt some interventions: better diagnosis, population and mayors information, search of technical and administrative settlements according to local environment.

Claims Protection in Construction Contracting.

Science.gov (United States)

1982-01-01

cotifAca 4’O or P04F oa &ACKPI&LOO QP/W SWiO GAIY. ADo 94Y1A16 ovat rRecos vor s.4, 0, W coq~mct. AIITU AWA -MVA4 A 3~ ~ ~ ~ puvR 17ear Cvtow AiD MftR 7W A/W...sequence (from the schedule) 4. Trends in project correspondence (look for the.3 start of a "paper record"). 42 sLou *- Wih I ons90;9 1 -;111. L With 15mm...competence is a risk that must be shared by each party, as they each have their own set of managers. It is an ongoing challenge for each organization to

New applications and novel processing of refractory metal alloys

International Nuclear Information System (INIS)

Briant, C.L.

2001-01-01

Refractory metals have often been limited in their application because of their propensity to oxidize and to undergo a loos of yield strength at elevated temperatures. However, recent developments in both processing and alloy composition have opened the possibility that these materials might be used in structural applications that were not considered possible in the past. At the same time, the use of refractory metals in the electronics industry is growing, particularly with the use of tantalum as a diffusion barrier for copper metallization. Finally, the application of grain boundary engineering to the problem of intergranular fracture in these materials may allow processes to be developed that will produce alloys with a greater resistance to fracture. (author)

Molecular Descriptors Family on Structure Activity Relationships 6. Octanol-Water Partition Coefficient of Polychlorinated Biphenyls

Directory of Open Access Journals (Sweden)

Lorentz JÄNTSCHI

2006-01-01

Full Text Available Octanol-water partition coefficient of two hundred and six polychlorinated biphenyls was model by the use of an original method based on complex information obtained from compounds structure. The regression analysis shows that best results are obtained in four-varied model (r2 = 0.9168. The prediction ability of the model was studied through leave-one-out analysis (r2cv(loo = 0.9093 and in training and test sets analysis. Modeling the octanol-water partition coefficient of polychlorinated biphenyls by integration of complex structural information provide a stable and performing four-varied model, allowing us to make remarks about relationship between structure of polychlorinated biphenyls and associated octanol-water partition coefficients.

Teatriateljee esitab pea peale pööratud maailma loomise loo / Taago Tubin ; interv. Elina Kononenko

Index Scriptorium Estoniae

Tubin, Taago, 1971-

2005-01-01

1. nov. esietendub Võru Teatriateljee esituses Võru Kultuurimajas Kannel A. Milleri näidendi "Creation of the World and other Business" järgi tehtud lavastus "Ilma luuminõ & muu äri" (lav. T. Tubin)

浅谈我国职业卫生管理%Discuss on ministration of profesional health

Institute of Scientific and Technical Information of China (English)

王晓锋

2006-01-01

职业卫生是保护劳动者健康，促进劳动力资源可持续发展的一项重要工作，一直受到党和政府的高度重视。劳动者的健康素质，直接关系到一个国家的生产力发展水平、发展质量和发展后劲。当前，我国职业卫生形势不容乐观，传统职业病危害仍在部分地区高发，新的职业危害又增加了控制的复杂性。按照依法治国和建设社会主义小康社会、和谐社会的要求，积极探索社会主义市场经济体制下加强职业卫生管理的举措日益重要，现就我国职业卫牛现状和对策进行简单分析。

Wear- and heat resistance of vacuum-arc TiN and TiAlN based coatings with Si and Y additives

International Nuclear Information System (INIS)

Aksenov, I.I.; Belous, V.A.; Grigor'ev, A.N.; Ermolenko, I.G.; Zadneprovskij, Yu.A.; Kovalenko, V.I.; Lomino, N.S.; Marinin, V.G.; Tolmacheva, G.N.; Sobol', O.V.

2011-01-01

It is shown, that insertion of silicon additives into TiN coatings and of yttrium into TiAlN coatings in explored limits (to a few wht. %) leads to increasing of resistance against abrasive friction wear. At the same time silicon or yttrium presence in the coatings leads to loos of their columnar structure and demonstrate decrease in the cavitation resistance. It is supposed, that such distinction in behaviour of the given working performances is a consequence of that mechanisms of the coating surface fracture at action of cavitation and abrasive friction are different. All explored coatings of (Ti-Si)N composition are not oxidised up to 600 o C, and of (Ti-Al-Y)N coatings - up to 800 o C.

Handbook of the Infrared Optical Properties of Al2O3. Carbon, MGO and ZrO2. Volume 1

Science.gov (United States)

1975-06-04

8217’~~~ 4-A- O*M 0 4V = M2 WC0t~CX4QVC𔃼MMD om0’wow. 11 t*0 ***@gWW W y4N0’IDW4q4V Wool 0ý 0 000 0 0*9009o a@O o0 o0*90~0,#*too f.. 4 0+4**40 loo 140...approximately 0.85 + 5 percent. Section 111-2.4 contains the processed data for e (T) found in the literature for many specific varieties of carbons...and Newall, A. j.., "The Emissivities of Flame Soot Dispersions, " Comb . and Flame 16, 191 (1971). 2N-9 Twitty, J. T., Weinman, J. A., "Radiative

2005 yearly days of petroleum

International Nuclear Information System (INIS)

Constant, R.; Susbielles, G.

2005-01-01

14 articles are gathered in this data sheet; they deal with the opening address of the 2005 petroleum days; the hydrocarbons: the evolutive resource; the para-petroleum engineers and the Europe; the speech of Mr Francois Loos; the Shell global scenarios to 2025; the evolution of the gas resource and its uses; the French para-petroleum industry; Bernard Bensaid, Corinne Sagary, Armelle Saniere, economic studies, IFP; the contribution of the innovation and of the technology in the diversification of the hydrocarbons supply; innovation and diversification of the petroleum resource: the point of view of Total; research, development and diversification of the petroleum resource; innovation in services companies; innovation in study and development and engineering; the closing address of the 2005 petroleum days. (O.M.)

Eating disorders among adolescents in South African public schools – a biblical perspective

Directory of Open Access Journals (Sweden)

S. Schoeman

2005-07-01

Full Text Available Society’s obsession with thinness and body image is part of every school’s hidden curriculum. The ideal to be skinny and thin resulted in an escalation in eating disorders among adolescents in South Africa. Some of the learners are only in the senior phase (Grades 7 to 9 of the general education and training band. It is therefore timely to review the problem of eating disorders, especially among adolescents in South African public schools. The purpose of this article is firstly to provide policy-makers, curriculum developers, educational ad-ministrators and educators with knowledge of the biblical view of health and to illustrate the pedagogical potential of such a view. Secondly the purpose is to assist Christian educators in teaching learners in public schools the necessary knowledge, skills, values and attitudes to counteract eating disorders by using, among other things, biblical truths.

Proximate composition of Turkish sesame seeds and characterization of their oils

Directory of Open Access Journals (Sweden)

Yalçın, Hasan

2008-03-01

Full Text Available A proximate composition of four varieties of Turkish sesame seeds (moisture, ash, protein, oil was determined along with a characterization of their oils (fatty acids, triacylglycerols and desmethylsterols The results of the proximate analysis showed the following contents: moisture, 4,40%; ash, 4,41%; protein, 21,00%; and oil, 54,26%. Oleic and linoleic acids were the major unsaturated fatty acids while palmitic and stearic were the main saturated. The triacylglycerol composition of the sesame oil samples was determined by HPLC and LOL; LOO; PLO; LLL; OOO were the major triglycerides while triacylglycerols containing oleic and linoleic acyl residues comprize 62,45% of the total. The major desmethyl sterols found in sesame seed oils were β-sitosterol, campasterol, stigma-sterol, and Δ-5, avenasterol. Small proportions of cholesterol, clerosterol 5,24 stigmastedienol, Δ-7, stigmastenol and avenasterol were also identified.Se ha evaluado la composición proximal de cuatro variedades de semillas de sésamo de Turquía así como el aceite obtenido mediante extracción en frío con hexano (composición en ácidos grasos, triglicéridos y esteroles. Las composiciones medias de las semillas fueron similares para todas las muestras siendo los valores medios 4,40%, 4,41%, 21,00%, 54,26% para humedad, cenizas, proteínas y aceite, respectivamente. Los ácidos oleico y linoleico fueron los ácidos grasos mayoritarios mientras los ácidos palmítico y estearico fueron los principales ácidos saturados. Los triglicéridos mayoritarios, determinados mediante HPLC fueron LOL; LOO; PLO; LLL y OOO, suponiendo un 62,45% del porcentaje total de los triglicéridos. Los esteroles mayoritarios fueron β-sitosterol, campesterol, estigmasterol, Δ-5, avenasterol, identificándose también pequeñas cantidades de colesterol, clerosterol 5,24 estigmastedienol, Δ-7 estigmastenol y avenasterol.

Optimization of automation: II. Estimation method of ostracism rate based on the loss of situation awareness of human operators in nuclear power plants

International Nuclear Information System (INIS)

Lee, Seung Min; Kim, Man Cheol; Kim, Jong Hyun; Seong, Poong Hyun

2015-01-01

Highlights: • We analyze the relationship between Out-of-the-Loop and the loss of human operators’ situation awareness. • We propose an ostracism rate estimation method by only considering the negative effects of automation. • The ostracism rate reflects how much automation interrupts human operators to receive information. • The higher the ostracism rate is, the lower the accuracy of human operators’ SA will be. - Abstract: With the introduction of automation in various industries including the nuclear field, its side effect, referred to as the Out-of-the-Loop (OOTL) problem, has emerged as a critical issue that needs to be addressed. Many studies have been attempted to analyze and solve the OOTL problem, but this issue still needs a clear solution to provide criteria for introducing automation. Therefore, a quantitative estimation method for identifying negative effects of automation is proposed in this paper. The representative aspect of the OOTL problem in nuclear power plants (NPPs) is that human operators in automated operations are given less information than human operators in manual operations. In other words, human operators have less opportunity to obtain needed information as automation is introduced. From this point of view, the degree of difficulty in obtaining information from automated systems is defined as the Level of Ostracism (LOO). Using the LOO and information theory, we propose the ostracism rate, which is a new estimation method that expresses how much automation interrupts human operators’ situation awareness. We applied production rules to describe the human operators’ thinking processes, Bayesian inference to describe the production rules mathematically, and information theory to calculate the amount of information that human operators receive through observations. The validity of the suggested method was proven by conducting an experiment. The results show that the ostracism rate was significantly related to the accuracy

RIDE vs. CLASP Comparison and Evaluation: Models and Parameters

Science.gov (United States)

2007-04-01

the model is declared "No Decision," indicating that neither QLRM nor LLRM provides a satisfactory fit. If p-value ( i 2j ) > p-value ( flj ), then our...evaluated at A = D = loo tD (7) UA/D(70,40) = 37.35 (8) UA/D(70,100) = 22.93 (9) OUA/D = 0 when evaluated at A = 70, D = 65.7 aD Note the number of...M U) U) C)U)f-~H W 0 U) co CQ CU)QC) W W 0 O40U) El)U tq D O U) U) E U) Z 04 X L X 4j c)c: o n n , f)cj" D ,m u)o mm o:zz .o tD o U) Uti)U) ’-4 r-4

The detail is dead - long live the detail!

DEFF Research Database (Denmark)

Larsen, Steen Nepper; Dalgaard, Kim; Kerstens, Vencent

2018-01-01

architecture when we look into architectural history. Too classic examples are; Adolf Loos who provoked already in 1908 with his statement; "Ornament and Crime", which contested the unconscious decorations of contemporary architects. Similarly, referring to the little need for superfluous detailing; "Less...... not change the fact that it is more important than ever to bring this 'small' architectural world to attention. Today, the construction industry is dictated by an economic management that does not leave much room for thorough studies of architectural details or visionary experiments. Today's more efficient......_Delft about the Symposium; "The Detail is Dead - Long Live the Detail". For this occasion a number of leading Danish and Northern European architects, researchers and companies were invited to discuss and suggest their 'architectural detail' and the challenges they face in today's construction. This book...

EXTRAGASTRIC AND ORODENTAL MANIFESTATIONS IN PEDIATRIC INFECTION WITH HELICOBACTER PYLORI. A REVIEW

Directory of Open Access Journals (Sweden)

Smaranda DIACONESCU

2015-12-01

Full Text Available Helicobacter pylori is a worlwide spread infection mostly manifested in childhood. Many - both invasive and non-invasive diagnostic tests - are now available,. The colonisation effect of gastric mucosa and its consequences are well known and studied. H. pylori can also induce extra-gastric manifestations, like iron-deficiency anemia. The role of oral cavity colonisation is not clearly defined, several studies stating that the oral cavity represents a reservoir for H. pyloris. The presence of this rod in the dental plaque may lead to periodontitis, dental caries, dental calculus and tooth loos. Dental treatment associated with eradication therapy decreases the prevalence of oral H. pylori and improves the eradication rate of gastric H. pylori. Dental treatment in H. pylori infection management should be taken into consideration, especially in children and teens.

Spatial-temporal features of thermal images for Carpal Tunnel Syndrome detection

Science.gov (United States)

Estupinan Roldan, Kevin; Ortega Piedrahita, Marco A.; Benitez, Hernan D.

2014-02-01

Disorders associated with repeated trauma account for about 60% of all occupational illnesses, Carpal Tunnel Syndrome (CTS) being the most consulted today. Infrared Thermography (IT) has come to play an important role in the field of medicine. IT is non-invasive and detects diseases based on measuring temperature variations. IT represents a possible alternative to prevalent methods for diagnosis of CTS (i.e. nerve conduction studies and electromiography). This work presents a set of spatial-temporal features extracted from thermal images taken in healthy and ill patients. Support Vector Machine (SVM) classifiers test this feature space with Leave One Out (LOO) validation error. The results of the proposed approach show linear separability and lower validation errors when compared to features used in previous works that do not account for temperature spatial variability.

Estudio de los microsatélites y miniSTRs del cromosoma X de aplicación forense

OpenAIRE

Castañeda Fernández, María

2013-01-01

Este trabajo se ha centrado en el estudio de microsatélites del cromosoma X, que se encuentran lo suficientemente próximos para ser analizados conjuntamente como haplotipos, con el objetivo de obtener los recursos necesarios para reconstruir pedigríes familiares que permitan resolver casos complejos de parentesco. Además, se ha focalizado en el desarrollo de nuevas herramientas moleculares para aumentar la eficacia del análisis de muestras de ADN altamente degradado y/o escaso. En primer...

Místní Agenda 21

OpenAIRE

CENIA, česká informační agentura životního prostředí

2013-01-01

Veletrh Česká příroda, kterým Ministerstvo životního prostředí současně zahájilo celoroční kampaň se stejným názvem, se uskutečnil v pátek 19. a sobotu 20. dubna 2013 od 10 do 18 hodin v prostorách pražského Národního domu na Vinohradech. Veletrh podpořil svou návštěvou v sobotu 20. dubna 2013 ministr životního prostředí Tomáš Chalupa, který zároveň pokřtil knihu Nejkrásnější výlety do chráněných krajinných oblastí ČR. Bohatý doprovodný program probíhal souběžně na několika místech Národního ...

Globalização e poder de estado: circulação internacional de elites e hierarquias do campo jurídico brasileiro

Directory of Open Access Journals (Sweden)

Fabiano Engelmann

2012-01-01

Full Text Available Prenant comme point de départ la problématique de la mondialisation des travaux d'experts concernant l'État, on examine les conditions d'internationalisation du champ juridique brésilien visant surtout le rapport entre le capital international mobilisé par les juristes et la hiérarchisation dans ce champ. Cette analyse part surtout de la comparaison des trajectoires universitaires, professionnelles et politiques de trois segments représentatifs de l'élite juridique: enseignants dans les cours de doctorat en droit, avocats associés aux plus importants cabinets juridiques et ministres du Supérieur Tribunal de Justice et du Supérieur Tribunal Fédéral. Les divers liens avec l'espace international peuvent être rapportés aux différentes positions dans le champ juridique brésilien et à leur relation avec l'espace politique et économique.

Novel qsar combination forecast model for insect repellent coupling support vector regression and k-nearest-neighbor

International Nuclear Information System (INIS)

Wang, L.F.; Bai, L.Y.

2013-01-01

To improve the precision of quantitative structure-activity relationship (QSAR) modeling for aromatic carboxylic acid derivatives insect repellent, a novel nonlinear combination forecast model was proposed integrating support vector regression (SVR) and K-nearest neighbor (KNN): Firstly, search optimal kernel function and nonlinearly select molecular descriptors by the rule of minimum MSE value using SVR. Secondly, illuminate the effects of all descriptors on biological activity by multi-round enforcement resistance-selection. Thirdly, construct the sub-models with predicted values of different KNN. Then, get the optimal kernel and corresponding retained sub-models through subtle selection. Finally, make prediction with leave-one-out (LOO) method in the basis of reserved sub-models. Compared with previous widely used models, our work shows significant improvement in modeling performance, which demonstrates the superiority of the present combination forecast model. (author)

Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.

Science.gov (United States)

Wang, Kun; Jiang, Tianzi; Liang, Meng; Wang, Liang; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Liu, Zhening

2006-01-01

In this work, we proposed a discriminative model of Alzheimer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD.

On the Aging of Objects

DEFF Research Database (Denmark)

Andersen, Bjørn Schiermer

2016-01-01

The article seeks to develop a new conceptual framework suitable for analysing the ageing processes of objects in modern culture. The basic intuition is that object experience cannot be analysed separately from collective participation. The article focuses on the question of the ‘timeless’ nature...... of modernist design and seeks to understand why modernist objects age more slowly than other objects. First, inspired by the late Durkheim’s account of symbolism, I turn to the experiential effects of collective embeddedness. Second, I enter the field of architectural practices and architectural theory....... Visiting early modernist ideologue Adolf Loos, I seek to understand the modernist attitude as a direct response to experiences of the acceleration of ageing processes characteristic of modern culture. I then try to show how Loos’s explicit awareness of the collective dimension is ignored by the subsequent...

Studies on non-traditional oils: l. Detailed studies on different lipid profiles of some Rosaceae kernel oils

Directory of Open Access Journals (Sweden)

Hassanein, Minar M. M.

1999-10-01

Full Text Available Kernel oils obtained from apricot, peach and plum, produced as by-products from food canning industry, were analyzed by capillary GC and HPLC. The fatty acid composition of the fractionated mono-, di- and triacylglycerol was elucidated. Oleic acid ranged from 64 to 72% in triacylglycerol (TAG, whereas linoleic acid ranged from 17% to 27%. The TAG profile showed the presence of 0 0 0 (35-42%, LOO (22-28%, LLO (7-16%, LOP and LLS (6-7%, OOP (6-10.4%. Campesterol-, 5-stigmasterol-, β-sitosterol-. isofucosterol, 7-stigmasterol and avenasterol were detected in the three analyzed oils. Sterylglycosides were also determined and showed some characteristic profiles. The three kernel oils contained appreciable amounts of tocopherols in which gamma-tocopherol was the predominating one. Alpha-and delta-tocopherols were also present in smaller quantities. Results obtained can be used to characterize these kernel oils and facilitate their differentiation from the other oils.

Aceites obtenidos de las semillas de albaricoque, melocotón y ciruela, producidos como subproductos de la industria alimenticia conservera, se analizaron mediante cromatografía gaseosa capilar y cromatografía líquida de alta resolución. Se estableció la composición en ácidos grasos de los mono-, di- y triacilgliceroles fraccionados. El ácido oleico osciló desde el 64% al 72% en triacilgliceroles (TAG, mientras que el ácido linoleico lo hizo entre el 17% y el 27%. El perfil de TAG mostró la presencia de OOO (35-42%, LOO (22-28%, LLO (7-16%, LOP y LLS (6-7%, OOP (6-10.4%. En los tres aceites analizados se detectaron campesterol-, 5-estigmasterol, β-sitosterol-, isofucosterol, 7-estigmasterol y avenasterol. También se determinaron glicósidos de esteroles, mostrando perfiles característicos. El contenido en tocoferoles fue apreciable en todos ellos, siendo el gamma-tocoferol el predominante. Los alfa- y delta-tocoferoles se detectaron en pequeñas cantidades. Los

Improvisation Theatre Performance as Maintaining and Breaking Cultural Model Narratives. Artiklis uuritakse, kuidas improvisatsiooniteater ja seda žanri harrastavad trupid kannavad edasi teatud tüüpi kultuurilisi narratiive, mida samas mõjutavad reaalsed

Directory of Open Access Journals (Sweden)

Reetta Jokinen

2012-04-01

Full Text Available Artiklis uuritakse, kuidas improvisatsiooniteater ja seda žanri harrastavad trupid kannavad edasi teatud tüüpi kultuurilisi narratiive, mida samas mõjutavad reaalsed sündmused nii etenduse ruumis kui väljaspool seda. Lähemalt analüüsitakse üht Jyväskyläs tegutseva Improvisatsiooniteatri Joo etendust, selles loodud tegelasi ning nende kaudu esitatavaid kultuurilisi narratiive, milles segunevad erinevad sotsiaalsed, ajaloolised ja müütilised teemad. Kuigi improvisatsiooniteatri ajaloo, meetodite ja eesmärkide kohta on avaldatud palju praktilise kallakuga käsiraamatuid, on seda valdkonda siiski vähe uuritud. Mis tegelikult juhtub, kui inimesed improviseerivad? Teine küsimuste ring on seotud improviseeritud loo temaatika ja dünaamikaga. Improteatri etendus on koht, kus mängitakse simultaanselt läbi mitmeid erinevaid narratiive, kusjuures igal hetkel on iga süžee puhul õhus mitmeid erinevaid arenguvõimalusi, millest mõned on aktuaalsemad kui teised. Need narratiivid võivad ka üksteist kommenteerida või osutada teistele tekstidele, näiteks isegi mõnele nii triviaalsele asjale nagu varem aset leidnud vestlusele. Tekste interpreteeritakse alati suhtes ümbritseva kultuurilise kontekstiga, teiste tekstide ja diskursustega. Artiklis vaadeldakse, kuidas etendajate tehtud valikud kinnistavad või küsitlevad erinevaid kultuurispetsiifilisi stereotüüpseid narratiive, kuidas neid narratiive saaks uutest vaatepunktidest interpreteerida ning kuidas need peegeldavad suhteid trupis. Improetenduses toimuvat ei käsitleta juhuslike sündmustena, vaid kompleksse mõjutuste kogumina, kus etenduse kultuuriline ja esteetiline väljund sõltuvad paljus proovimeetodist, trupi dünaamikast, etendajate unikaalsetest isiklikest narratiividest ja tegeliku elu sündmustest ning laiemast kultuurikontekstist. Improetenduse puhul ei ole kuigi lihtne eristada ühe etendaja valikuid või etenduse pöördepunkte, sest kogu protsess põhineb t

Detailed studies on some lipids of Silybum marianum(L. seed oil

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Hassanein, Minar M.

2003-12-01

Full Text Available Eight lipid patterns of Silybum marianum (L. Gaertn seed oil, not hitherto reported, (20% have been elucidated in this laboratory using capillary GLC and HPLC as main tools of analysis. The oil is rich in linoleic acid (53.3% and oleic acid (21.3%. Five major triacylglycerols containing linoleic acyls namely LLL, LLO, LLP, LOO and LOP were detected by HPLC using FID detector, these triacylglycerols are also predominating in both cottonseed and sunflower oils but in different proportions. The total tocopherols content (260 ppm was determined directly in the oil by HPLC. It was found that the oil contains alpha -tocopherol as a major constituent (84.5% resembling sunflower oil. The whole sterols pattern, as determined as their trimethylsilyl derivatives by GLC, includes campesterol, 5-stigmasterol, beta-sitosterol, 7-stigmasterol, avenasterol and spinasterol. The four sterols lipid clases of free and acylated sterols and sterylglycosides have been determined as their 9- and 1- anthroylnitrile derivatives by fluorescence and UV- HPLC respectively.La composición de ocho tipos de lípidos en aceite de semillas de Silybum marianum (L. Gaertn, hasta ahora no reportados, han sido identificados en este laboratorio, usando GLC capilar y HPLC como herramientas principales de análisis. El aceite es rico en ácidos linoleico (53,3% y oleico (21,3%. El ácido linoleico está contenido principalmente en cinco formas de triacilgliceroles: LLL, LLO, LLP, LOO y LOP, detectadas por HPLC, usando un detector FID, estos triacilgliceroles son también predominantes en los aceites de semillas de algodón o girasol, pero con diferentes proporciones. El contenido total de tocoferoles (260 ppm fue determinado directamente en el aceite por HPLC. Se encontró que el aceite contenía alfa-tocoferol como principal constituyente (84,5%, recordando al aceite de girasol. El patrón completo de esteroles determinado por GLC como derivados de trimetilsilil incluyó campesterol

Primary intraosseous squamous cell carcinoma in odontogenic keratocyst: A rare entity

Science.gov (United States)

Saxena, Chitrapriya; Aggarwal, Pooja; Wadhwan, Vijay; Bansal, Vishal

2015-01-01

Squamous cell carcinoma (SCC) arising from the wall of an odontogenic cyst (also known as primary intraosseous carcinoma) is a rare tumor which occurs only in jaw bones. This tumor was first described by Loos in 1913 as a central epidermoid carcinoma of the jaw. Primary intraosseous carcinomas (PIOC) may theoretically arise from the lining of an odontogenic cyst or de novo from presumed odontogenic cell rests. According to the new histological classification of tumors of the World Health Organization, odontogenic keratocyst is nowadays considered a specific odontogenic tumor and the PIOC derived from it is considered as a specific entity which is different from other PIOCs derived from the odontogenic cysts. The following report describes a case of such extremely rare entity that is primary intraosseous SCC of the mandible derived from an OKC in a 60-year-old male patient with brief review of literature. PMID:26980976

QSAR studies for the acute toxicity of nitrobenzenes to the Tetrahymena pyriformis

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Wang Dan-Dan

2014-01-01

Full Text Available Quantitative structure-activity relationship (QSAR models play a key role in finding the relationship between molecular structures and the toxicity of nitrobenzenes to Tetrahymena pyriformis. In this work, genetic algorithm, along with partial least square (GA-PLS was employed to select optimal subset of descriptors that have significant contribution to the toxicity of nitrobenzenes to Tetrahymena pyriformis. A set of five descriptors, namely G2, HOMT, G(Cl…Cl, Mor03v and MAXDP, was used for the prediction of the toxicity of 45 nitrobenzene derivatives and then were used to build the model by multiple linear regression (MLR method. It turned out that the built model, whose stability was confirmed using the leave-one-out validation and external validation test, showed high statistical significance (R2=0.963, Q2LOO=0.944. Moreover, Y-scrambling test indicated there was no chance correlation in this model.

Additive theory of prime numbers

CERN Document Server

Hua, L K

2009-01-01

Loo-Keng Hua was a master mathematician, best known for his work using analytic methods in number theory. In particular, Hua is remembered for his contributions to Waring's Problem and his estimates of trigonometric sums. Additive Theory of Prime Numbers is an exposition of the classic methods as well as Hua's own techniques, many of which have now also become classic. An essential starting point is Vinogradov's mean-value theorem for trigonometric sums, which Hua usefully rephrases and improves. Hua states a generalized version of the Waring-Goldbach problem and gives asymptotic formulas for the number of solutions in Waring's Problem when the monomial x^k is replaced by an arbitrary polynomial of degree k. The book is an excellent entry point for readers interested in additive number theory. It will also be of value to those interested in the development of the now classic methods of the subject.

Smooth homogeneous structures in operator theory

CERN Document Server

Beltita, Daniel

2005-01-01

Geometric ideas and techniques play an important role in operator theory and the theory of operator algebras. Smooth Homogeneous Structures in Operator Theory builds the background needed to understand this circle of ideas and reports on recent developments in this fruitful field of research. Requiring only a moderate familiarity with functional analysis and general topology, the author begins with an introduction to infinite dimensional Lie theory with emphasis on the relationship between Lie groups and Lie algebras. A detailed examination of smooth homogeneous spaces follows. This study is illustrated by familiar examples from operator theory and develops methods that allow endowing such spaces with structures of complex manifolds. The final section of the book explores equivariant monotone operators and Kähler structures. It examines certain symmetry properties of abstract reproducing kernels and arrives at a very general version of the construction of restricted Grassmann manifolds from the theory of loo...

Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

Index Scriptorium Estoniae

Palm, Jaanika, 1973-

2008-01-01

Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

Index Scriptorium Estoniae

Palm, Jaanika, 1973-

2007-01-01

Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

Application of QSAR models in analysis of antibacterial activity of some benzimidazole derivatives against Sarcina lutea

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Podunavac-Kuzmanović Sanja O.

2013-01-01

Full Text Available In the present paper, a quantitative structure activity relationship (QSAR has been carried out on a series of 2-methyl and 2-aminobenzimidazole derivatives to identify the lipophilicity requirements for their inhibitory activity against bacteria Sarcina lutea. The tested compounds displayed in vitro antibacterial activity and minimum inhibitory concentration (MIC was determined for all compounds. The partition coefficients of the studied compounds were measured by the shake flask method (log P and by theoretical calculation (Clog P. The relationships between lipophilicity descriptors and antibacterial activities were investigated and the mathematical models have been developed as a calibration models for predicting the inhibitory activity of this class of compounds. The models were validated by leave-one-out (LOO technique as well as by the calculation of statistical parameters for the established models. Therefore, QSAR analysis reveals that lipophilicity descriptor govern the inhibitory activity of benzimidazoles studied against Sarcina lutea.

“La Constitución de los Pueblos de Occidente”. Une proposition inédite du voyageur cAlî Bey l’Abbasside pour le Maroc dans l´Arxiu Històric de la Ciutat de Barcelona (AHCB, Col. Toda, Ms B.162-II

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Mercè Viladrich

2006-11-01

Full Text Available L’objectif de ce travail est de faire connaître et d’éditer à partir d’un manuscrit autographe le texte intitulé Constitution des peuples d´Occident rédigé par le voyageur catalan Domènec Badía i Leblich (1767-18181, connu sous le nom d’cAlî Bey l’Abbasside. Cette grande charte était destinée à s´implanter comme texte légal dans l´Empire du Maroc. Fonctionnaire au service du premier ministre de Carlos IV, Manuel de Godoy, Domènec Badía voyagea en 1803 au Maroc, dans la péninsule Arabique et au Moyen Orient et gagna une certaine célébrité parmi ses contemporains en racontant ses aventures dans un récit Les voyages d´Ali Bey en Asie et en Afrique, œuvre qui mélange vérité historique et fiction et dans laquelle l´auteur révèle une psychologie pathologique.

ROLE OF COMMON VESTRY OF ST. NICHOLAS CHURCH IN MAROSEIKA STREET IN SPIRITUAL LIFE OF MOSCOW IN XXTH CENTURY

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Анна Филипповна Грушина

2015-12-01

Full Text Available The article concentrates on the history of the formation and development of the Common Vestry of Moscow Church of St. Nicholas in Klenniki. There are revealed the outstanding characteristics of the living, its spiritual origins and bonds. In the centre of the research is the ministration of two hegumens of the church, namely: archpriest Alexius Mechov and his son priest Sergius Mechov. The father started the penancing-liturgical family and the son continued the father's work, retained and enriched his pastoral heritage. The Common Vestry of the Church of St. Nicholas in Klenniki, which had been guided by father Sergius, turned out to be one of the most wonderful phenomena of the Russian Church history of the previous century. In the years of the persecutions against the Church it survived. The peculiarity of this living was that it was disintegrated after the shutdown of the church and the taking away of the pastors. This peculiarity is unique not only for Moscow, but also for all Russian Orthodox Church.

Varennes Tokamak

International Nuclear Information System (INIS)

Cumyn, P.B.

A consortium of five organizations under the leadership of IREQ, the Institute de Recherche d'Hydro-Quebec has completed a conceptual design study for a tokamak device, and in January 1981 its construction was authorized with funding being provided principally by Hydro-Quebec and the National Research Council, as well as by the Ministre d'Education du Quebec and Natural Sciences and Engineering Research Council of Canada (NSERC). The device will form the focus of Canada's magnetic-fusion program and will be located in IREQ's laboratories in Varennes. Presently the machine layout is being finalized from the physics point of view and work has started on equipment design and specification. The Tokamak de Varennes will be an experimental device, the purpose of which is to study plasma and other fusion related phenomena. In particular it will study: 1. Plasma impurities and plasma/liner interaction; 2. Long pulse or quasi-continuous operation using plasma rampdown and eventually plasma current reversal in order to maintain the plasma; and 3. Advanced diagnostics

Conversations cruciales des outils pour s'exprimer quand les enjeux sont de taille

CERN Document Server

Patterson, Kerry; McMillan, Ron; Switzler, Al; Covey, Stephen R

2009-01-01

Quand on parle de " conversations cruciales ", il nous vient spontanément des images de présidents, d'empereurs et de Premiers ministres assis autour d'une table massive en train de débattre de l'avenir du monde. Les conversations dont parle cet ouvrage ne sont pas moins cruciales, nous concernent tous et peuvent survenir à n'importe quel moment dans notre vie quotidienne. Une discussion houleuse avec le patron, une dispute violente avec un collègue ou un client, un mot de trop adressé à notre conjoint, etc. Une conversation devient cruciale quand : les opinions en jeu sont opposées ; les enjeux sont importants ; les émotions sont fortes. Ce livre vous aide à vous exprimer habilement quand les enjeux sont de taille. Il vous explique comment atteindre le but que vous vous êtes fixé en usant des meilleures techniques et en ouvrant le chemin du dialogue. Il vous fournit les outils pour gérer les conversations les plus difficiles et les plus importantes de votre vie.

La dimension publicitaire du storytelling politique

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Andreea Monica State

2016-11-01

Full Text Available Le thème général de cet article fait référence à la dimension publicitaire de la narration politique. J'ai choisi ce sujet parce que les histoires font partie de la vie humaine depuis longtemps, utilisées pour transmettre la tradition et enseigner des modèles de comportement social. Récemment, des histoires ont été utilisées de plus en plus souvent à des fins diverses telles que la publicité, la gestion ou la politique. Cet article vise à réaliser une recherche qualitative qui combine l'analyse du contenu et l'analyse du discours. En dehors de la base théorique qui vise à clarifier les concepts de base de la recherche, j’étudie la narration politique utilisée par l'ancien Président Traian Basescu et l'ancien Premier Ministre Victor Ponta dans les biographies en ligne, puis une analyse de leurs discours lors de la Fête Nationale de la Roumanie et l'Union des Principautés Roumaines.

Peran Pemerintah dalam Perencanaan Pembangunan Lapangan Golf Kintamani dengan Prinsip Pariwisata Berkelanjutan

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Rila Hilma

2013-05-01

Full Text Available Planning a tourist destination, some aspects need to be considered concerning government’s role, surrounding society, and sustainable development principles. The project of golf court in caldera Gunung Batur must be analysed by some experts. This study aims to anticipate some new troubles that might come up when the construction of golf court begins. Above it all, every study has opportunity to be applied whether by regional or national government, who responsibly takes control of the region, once they approved the project. Based on it, the plan of golf court construction in Kintamani, Bangli regency, Bali Province (as cited by www.bisnisbali.com on 27th January 2011 proposed by Ministre Jero Wacik and approved by the parlement members of DPRD Bangli, concerns the principles of sustainable tourism which could prevent, especially Kintamani region, from deconstructed side effects of the development. This research applies qualitative-descriptive method supported by literature review and news from media, especially online media which are able to provide the actual news from Kintamani region.

Ministr sotsialnõhh del Eiki Nestor : "Ja bõ s radostju ostalsja v profsojuze" / Eiki Nestor ; interv. Sofja Bauer

Index Scriptorium Estoniae

Nestor, Eiki, 1953-

2000-01-01

Autor: Rahvaerakond Mõõdukad. Intervjuu sotsiaalministriga: ametiühingutöö, pensionireform, kaevurite pensionid, töötute sotsiaalkaitse, tervishoiuasutuste reformid. Ilmunud ka: Põhjarannik 2. veebr. lk. 2

Chemoviscosity modeling for thermosetting resins, 2

Science.gov (United States)

Hou, T. H.

1985-01-01

A new analytical model for simulating chemoviscosity of thermosetting resin was formulated. The model is developed by modifying the Williams-Landel-Ferry (WLF) theory in polymer rheology for thermoplastic materials. By assuming a linear relationship between the glass transition temperature and the degree of cure of the resin system under cure, the WLF theory can be modified to account for the factor of reaction time. Temperature dependent functions of the modified WLF theory constants were determined from the isothermal cure data of Lee, Loos, and Springer for the Hercules 3501-6 resin system. Theoretical predictions of the model for the resin under dynamic heating cure cycles were shown to compare favorably with the experimental data reported by Carpenter. A chemoviscosity model which is capable of not only describing viscosity profiles accurately under various cure cycles, but also correlating viscosity data to the changes of physical properties associated with the structural transformations of the thermosetting resin systems during cure was established.

Performance evaluation of the EM algorithm applied to radiographic images

International Nuclear Information System (INIS)

Brailean, J.C.; Giger, M.L.; Chen, C.T.; Sullivan, B.J.

1990-01-01

In this paper the authors evaluate the expectation maximization (EM) algorithm, both qualitatively and quantitatively, as a technique for enhancing radiographic images. Previous studies have qualitatively shown the usefulness of the EM algorithm but have failed to quantify and compare its performance with those of other image processing techniques. Recent studies by Loo et al, Ishida et al, and Giger et al, have explained improvements in image quality quantitatively in terms of a signal-to-noise ratio (SNR) derived from signal detection theory. In this study, we take a similar approach in quantifying the effect of the EM algorithm on detection of simulated low-contrast square objects superimposed on radiographic mottle. The SNRs of the original and processed images are calculated taking into account both the human visual system response and the screen-film transfer function as well as a noise component internal to the eye-brain system. The EM algorithm was also implemented on digital screen-film images of test patterns and clinical mammograms

High-Temperature Test of 800HT Printed Circuit Heat Exchanger in HELP

International Nuclear Information System (INIS)

Kim, Chan Soo; Hong, Sung-Deok; Kim, Min Hwan; Shim, Jaesool

2014-01-01

Korea Atomic Energy Research Institute has developed high-temperature Printed Circuit Heat Exchangers (PCHE) for a Very High Temperature gas-cooled Reactor and operated a very high temperature Helium Experimental LooP (HELP) to verify the performance of the high temperature heat exchanger at the component level environment. PCHE is one of the candidates for the intermediate heat exchanger in a VHTR, because its design temperature and pressure are larger than any other compact heat exchanger types. High temperature PCHEs in HELP consist of an alloy617 PCHE and an 800HT PCHE. This study presents the high temperature test of an 800HT PCHE in HELP. The experimental data include the pressure drops, the overall heat transfer coefficients, and the surface temperature distributions under various operating conditions. The experimental data are compared with the thermo-hydraulic analysis from COMSOL. In addition, the single channel tests are performed to quantify the friction factor under normal nitrogen and helium inlet conditions. (author)

The first president's pathway into ESTSS: memories and ideas for future issue. Patients as partners

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Erica M. Van der Schrieck-De Loos

2013-06-01

Full Text Available This article addresses Wolter De Loos’ pathway into ESTSS that ended on 6th January 2004. His footsteps are still printed in the field of psychotraumatology as he showed the field how a physician was trying to integrate his working field with that of psychiatry, with a great passion for his patients. Erica M. Van der Schrieck-De Loos outlines the perspectives of her father as funding president of the ESTSS by using his Opening Address of the Fourth ESTSS Conference in 1995. This address emphasized that the mixture of righteousness and offence in warfare is ubiquitious and everlasting. The perspective of the first president's pathway has been integrated with the current vision of the author to show that the patient can be a partner of the healthcare team. A suggestion for ESTSS main objective number (8, contained within the ESTSS mission statement, is to involve patients as partners of the traumatic stress care team into accelerating traumatic stress care across Europe and beyond.

Mathematical modeling of tetrahydroimidazole benzodiazepine-1-one derivatives as an anti HIV agent

Science.gov (United States)

Ojha, Lokendra Kumar

2017-07-01

The goal of the present work is the study of drug receptor interaction via QSAR (Quantitative Structure-Activity Relationship) analysis for 89 set of TIBO (Tetrahydroimidazole Benzodiazepine-1-one) derivatives. MLR (Multiple Linear Regression) method is utilized to generate predictive models of quantitative structure-activity relationships between a set of molecular descriptors and biological activity (IC50). The best QSAR model was selected having a correlation coefficient (r) of 0.9299 and Standard Error of Estimation (SEE) of 0.5022, Fisher Ratio (F) of 159.822 and Quality factor (Q) of 1.852. This model is statistically significant and strongly favours the substitution of sulphur atom, IS i.e. indicator parameter for -Z position of the TIBO derivatives. Two other parameter logP (octanol-water partition coefficient) and SAG (Surface Area Grid) also played a vital role in the generation of best QSAR model. All three descriptor shows very good stability towards data variation in leave-one-out (LOO).

Benchmarking Methods and Data Sets for Ligand Enrichment Assessment in Virtual Screening

Science.gov (United States)

Xia, Jie; Tilahun, Ermias Lemma; Reid, Terry-Elinor; Zhang, Liangren; Wang, Xiang Simon

2014-01-01

Retrospective small-scale virtual screening (VS) based on benchmarking data sets has been widely used to estimate ligand enrichments of VS approaches in the prospective (i.e. real-world) efforts. However, the intrinsic differences of benchmarking sets to the real screening chemical libraries can cause biased assessment. Herein, we summarize the history of benchmarking methods as well as data sets and highlight three main types of biases found in benchmarking sets, i.e. “analogue bias”, “artificial enrichment” and “false negative”. In addition, we introduced our recent algorithm to build maximum-unbiased benchmarking sets applicable to both ligand-based and structure-based VS approaches, and its implementations to three important human histone deacetylase (HDAC) isoforms, i.e. HDAC1, HDAC6 and HDAC8. The Leave-One-Out Cross-Validation (LOO CV) demonstrates that the benchmarking sets built by our algorithm are maximum-unbiased in terms of property matching, ROC curves and AUCs. PMID:25481478

Benchmarking methods and data sets for ligand enrichment assessment in virtual screening.

Science.gov (United States)

Xia, Jie; Tilahun, Ermias Lemma; Reid, Terry-Elinor; Zhang, Liangren; Wang, Xiang Simon

2015-01-01

Retrospective small-scale virtual screening (VS) based on benchmarking data sets has been widely used to estimate ligand enrichments of VS approaches in the prospective (i.e. real-world) efforts. However, the intrinsic differences of benchmarking sets to the real screening chemical libraries can cause biased assessment. Herein, we summarize the history of benchmarking methods as well as data sets and highlight three main types of biases found in benchmarking sets, i.e. "analogue bias", "artificial enrichment" and "false negative". In addition, we introduce our recent algorithm to build maximum-unbiased benchmarking sets applicable to both ligand-based and structure-based VS approaches, and its implementations to three important human histone deacetylases (HDACs) isoforms, i.e. HDAC1, HDAC6 and HDAC8. The leave-one-out cross-validation (LOO CV) demonstrates that the benchmarking sets built by our algorithm are maximum-unbiased as measured by property matching, ROC curves and AUCs. Copyright © 2014 Elsevier Inc. All rights reserved.

Storia di un Vulcano I GPS di Trimble per monitorare Mount St. Helen

Directory of Open Access Journals (Sweden)

Edoardo Carlucci

2005-10-01

Full Text Available Venticinque anni fa il peggior disastro vulcanico nella storia degli Stati Uniti attirò l’attenzione di tutto il mondo. L’esplosione, preceduta da un paio di mesi di piccole scosse di terremoto, squarciò il fianco Nord del vulcano St. Helens il 18 maggio 1980, provocando allo stesso tempo il più grande smottamento della storia. L’eruzione seguente all’esplosione cancellò tutta l’area circostante, facendo 57 vittime tra la popolazione e formando un profondo cratere a forma di ferro di cavallo; per sei anni si susseguirono altre piccole eruzioni che portarono alla formazione di un’altra cupola lavica dopodiché Loo-wit (il Guardiano del Fuoco, come i nativi americani usavano chiamare il vulcano St. Helens, si addormentò di nuovo. Prima del fatidico giorno Mount St. Helens era la nona cima per altezza negli Stati Uniti; dopo il 18 maggio essa diventava la trentesima.

Metal research

International Nuclear Information System (INIS)

Rottwinkel, T.

1977-01-01

The five diffusion coefficients necessary for a complete description of diffusion have been measured as a function of concentration for samples tempered under equal conditions at 1137+-1 K. Using the tracer Au-195 the common diffusion constants D tilde could be determined with the same accuracy as the tracer diffusion constants D*Cu and D*Au. The partial constants DCu and DAu have been determined by the method of van Loo and also by a new method (Slide method). Extrapolation of the DCu values for infinite dilution results in a ratio DCu/DCu (O) of 2.12. Including the effect of changing molar volumes the quantity LAB/LBB is determined to be 1.88. Calculation of the ratio DCu/D*Cu using the increase factors b tilde and b*Au of the common and Au-tracer diffusion constant respectively, gives the value 1.87, confirming the extrapolated result with an error of 12%. (orig./WBU) [de

Quick detection and quantification of iron-cyanide complexes using fourier transform infrared spectroscopy

International Nuclear Information System (INIS)

Sut-Lohmann, Magdalena; Raab, Thomas

2017-01-01

The continuous release of persistent iron-cyanide (Fe-CN) complexes from various industrial sources poses a high hazard to the environment and indicates the necessity to analyze a considerable amount of samples. Conventional flow injection analysis (FIA) is a time and cost consuming method for cyanide (CN) determination. Thus, a rapid and economic alternative needs to be developed to quantify the Fe-CN complexes. 52 soil samples were collected at a former Manufactured Gas Plant (MGP) site in order to determine the feasibility of diffuse reflectance infrared Fourier spectroscopy (DRIFTS). Soil analysis revealed CN concentrations in a range from 8 to 14.809 mg kg −1 , where 97% was in the solid form (Fe 4 [Fe(CN) 6 ] 3 ), which is characterized by a single symmetrical CN band in the range 2092–2084 cm −1 . The partial least squares (PLS) calibration-validation model revealed IR response to CN tot which exceeds 2306 mg kg −1 (limit of detection, LOD). Leave-one-out cross-validation (LOO-CV) was performed on soil samples, which contained low CN tot (<900 mg kg −1 ). This improved the sensitivity of the model by reducing the LOD to 154 mg kg −1 . Finally, the LOO-CV conducted on the samples with CN tot  > 900 mg kg −1 resulted in LOD equal to 3751 mg kg −1 . It was found that FTIR spectroscopy provides the information concerning different CN species in the soil samples. Additionally, it is suitable for quantifying Fe-CN species in matrixes with CN tot  > 154 mg kg −1 . Thus, FTIR spectroscopy, in combination with the statistical approach applied here seems to be a feasible and quick method for screening of contaminated sites. - Highlights: • A protocol for a quick and cheap quantitative cyanide analysis in soil using FTIR is proposed. • Splitting of the data, resulting in low and high CN set, reduced the LOD and increased the sensitivity of the model. • Regression coefficients indicate positive response of IR frequencies to

La peinture religieuse monumentale, une expression artistique emblématique du nord de la France au XIXe siècle ?

Directory of Open Access Journals (Sweden)

Catherine Guillot

2012-04-01

Full Text Available Issue d’une première tentative de synthèse portant sur la peinture monumentale religieuse à Lille dans la seconde moitié du XIXe siècle, cette étude permet d’exhumer l’œuvre d’artistes régionaux, mais également belges et néerlandais, mettant en évidence le rôle de carrefour de l’actuelle métropole lilloise. Dans une région fortement marquée par le catholicisme, les sujets traités sont à la fois le reflet des dévotions nationales et de cultes plus locaux, que ce soit à travers la figure de saint Vincent de Paul, le rôle de la Vierge ou la dévotion aux âmes du purgatoire qui prend une importance particulière à partir du foyer de Loos. Cette expression artistique et religieuse se développe sous la forme de grands cycles dont la réalisation connaît son apogée sous la IIIe République, en particulier de 1880 à 1900. Une fois ce panorama dressé, il devient possible d’interroger les catégories traditionnelles de l’art à cette époque, la notion centrale de primitivisme et les jugements de valeur auxquels cette peinture est encore souvent soumise.This article is based on a synthetic analysis of monumental religious painting at Lille during the second half of the 19th century. This study led to the rediscovery of many regional artists, but also Belgian and Dutch artists, underlining the long history of Lille’s present-day position as an international crossroads. In a region which was strongly marked by Catholicism, the subjects dealt with offer a reflection of national devotional practices but also draw attention to more local cults. Examples here include the figure of Saint Vincent de Paul, the role of the Virgin Mary and the devotion to souls in purgatory, which is particularly important in Loos. This artistic and religious expression develops according to major cycles which reached a high point during the Third Republic, and particularly from 1880 to 1890. Once this general overview has been established

THEORY AND PRACTICE IN THE WORKSHOP OF EXPRESSION VISUAL-GRAPHICS FOR MULTIPLIERS - DAC / UFSC.

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Richard Perassi Sousa

2010-12-01

Full Text Available This paper presents theoretical reasons and procedures that structure the practices of free artistic expression in working with adolescents and adults. The goal is to identify and justify the theory, pedagogical methods and the practical activities developed with the multipliers for the release of graphic and plastic expression, as an exercise in personal expression within a social context. The method adopted provides a theoretical justification and development activities of artistic expression-visual graph, as a field of significant interaction between subject and his inner universe. These activities are motivated by the need for expression, which is inherent in human beings, requiring the participants' ministrator and planning and organization. Therefore, beyond the scope of self-expressive, the proposed activities serve as the organizing principle subject to significant social and working life. Here are the relevant issues included the theoretical and practical theories "Free Expression" and "Education through Art." The procedures described here were developed with teachers, artists and other participants of "Workshop of expression visual-graphics for multipliers" held at the Departamento de Arte e Cultura (DAC / UFSC within the Project Arte na Escola in the years 2008 and 2009.

Reformas policiales y narrativas institucionales en argentina: renombrando escuelas de policía

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Mariana Sirimarco

2013-09-01

Full Text Available En avril 2011, la Ministre de la Sécurité en Argentine s'est prononcée favorablement pour le changement de nom des écoles de la Police Fédérale argentine, en cessant de rappeler les noms des chefs associés à la répression policière, pour rendre hommage aux officiers soucieux de la préservation des droits de l'homme. Dans cet article, on comprend, à partir de l'analyse de divers documents et articles de journaux, que les mots "créent" et "soutiennent" les rapports et les situations sociales, puisqu'ils communiquent des identités et permettent une certaine expérience de la réalité. Ainsi, on cherche à y examiner ces réformes sur leur plan symbolique d'action, en révélant leur trame de discours et d'évaluation, tout en discutant le poids et le but des réformes policières et leurs tentatives d'adéquation au contexte politique actuel. En conclusion, on présente aussi certains usages et appropriations de l'histoire et de la mémoire.

Development in the Slovakia. General environmental science

International Nuclear Information System (INIS)

1998-01-01

In this chapter the basic of the environmental science and preservation of the natural memories; The protection of the nature and landscape; The protection of the forest; The protection of the trees growing outside of the forests, parks and gardens; The protection of free growing of species of plants; The protection of free living species of animals; The protection of animals and game law; The protection of fishes and fishery; The water protection, their balance and water farm; The health protection of the man (Radiation protection and nuclear safety is included); The veterinary ministration and protection of animals; The air protection and protection of the ozone layer; Wastes and waste management; The protection and agricultural use of soil; The protection and use of minerals; The protection of cultural heritage in the landscape; The territorial planning, building order and environmental rationalizing; The assessment of influences on the environment; The state fund of the environment; The state administration for the environment; The access to environmental information; The law about the environment and basic meanings of the environmentalism; The environmental terminology in the environmental law; The environmental terminology in the development and documents of environmental law are reviewed

Les enjeux éthiques de l’élaboration des politiques publiques favorables à la santé : réflexion et illustration

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Danielle Blondeau

2011-06-01

Full Text Available Au Québec, en vertu de la Loi sur la santé publique (L.R.Q. chapitre S-2.2, 2001, article 54, le ministre de la Santé a un droit de regard sur les mesures prévues par les autres ministères dans leurs lois et règlements qui pourraient avoir un impact significatif sur la santé de la population. Ainsi, les acteurs de santé publique du palier central ont cherché à soutenir la mise en oeuvre de cet article, de manière à favoriser l’adoption de politiques publiques favorables à la santé. Ce texte examine les enjeux éthiques liés à l’élaboration de telles politiques. Après avoir exposé les tensions entre bien individuel et bien commun ainsi que les valeurs de justice sociale, responsabilité et démocratie qui y sont reliées, nous illustrerons les enjeux éthiques à travers l’exemple du cinémomètre photographique comme mesure visant à augmenter la sécurité routière.

STR melting curve analysis as a genetic screening tool for crime scene samples.

Science.gov (United States)

Nguyen, Quang; McKinney, Jason; Johnson, Donald J; Roberts, Katherine A; Hardy, Winters R

2012-07-01

In this proof-of-concept study, high-resolution melt curve (HRMC) analysis was investigated as a postquantification screening tool to discriminate human CSF1PO and THO1 genotypes amplified with mini-STR primers in the presence of SYBR Green or LCGreen Plus dyes. A total of 12 CSF1PO and 11 HUMTHO1 genotypes were analyzed on the LightScanner HR96 and LS-32 systems and were correctly differentiated based upon their respective melt profiles. Short STR amplicon melt curves were affected by repeat number, and single-source and mixed DNA samples were additionally differentiated by the formation of heteroduplexes. Melting curves were shown to be unique and reproducible from DNA quantities ranging from 20 to 0.4 ng and distinguished identical from nonidentical genotypes from DNA derived from different biological fluids and compromised samples. Thus, a method is described which can assess both the quantity and the possible probative value of samples without full genotyping. 2012 American Academy of Forensic Sciences. Published 2012. This article is a U.S. Government work and is in the public domain in the U.S.A.

New theory of discriminant analysis after R. Fisher advanced research by the feature selection method for microarray data

CERN Document Server

Shinmura, Shuichi

2016-01-01

This is the first book to compare eight LDFs by different types of datasets, such as Fisher’s iris data, medical data with collinearities, Swiss banknote data that is a linearly separable data (LSD), student pass/fail determination using student attributes, 18 pass/fail determinations using exam scores, Japanese automobile data, and six microarray datasets (the datasets) that are LSD. We developed the 100-fold cross-validation for the small sample method (Method 1) instead of the LOO method. We proposed a simple model selection procedure to choose the best model having minimum M2 and Revised IP-OLDF based on MNM criterion was found to be better than other M2s in the above datasets. We compared two statistical LDFs and six MP-based LDFs. Those were Fisher’s LDF, logistic regression, three SVMs, Revised IP-OLDF, and another two OLDFs. Only a hard-margin SVM (H-SVM) and Revised IP-OLDF could discriminate LSD theoretically (Problem 2). We solved the defect of the generalized inverse matrices (Problem 3). For ...

60 years: sleek and stylish

CERN Multimedia

Anaïs Schaeffer

2013-01-01

As you are aware, CERN will be celebrating its 60th birthday in 2014. To mark the event, next year will be filled with exciting events... of which there will be a taster in the next issue of the Bulletin.   In the meantime, we are pleased to present the official logo for this important anniversary: created by the Graphic Design Service team, it elegantly combines the curves of the numbers 6 and 0 to mirror the shape of our accelerator chain, and in doing so pays homage to the technological prowess of CERN’s installations. The overlap of the 6 and the 0 also symbolises collaboration between countries, professions and people, which is one of the Organization’s fundamental values. The slightly tilted perspective of the logo suggests the geographical layout of CERN’s facilities as well as the dynamism of a forward-looking Laboratory. There’s an obvious nod to the CERN logo, but the new logo differs in the way it evokes a more festive spirit: formed of a loo...

Molecular docking and 3D-QSAR studies on inhibitors of DNA damage signaling enzyme human PARP-1.

Science.gov (United States)

Fatima, Sabiha; Bathini, Raju; Sivan, Sree Kanth; Manga, Vijjulatha

2012-08-01

Poly (ADP-ribose) polymerase-1 (PARP-1) operates in a DNA damage signaling network. Molecular docking and three dimensional-quantitative structure activity relationship (3D-QSAR) studies were performed on human PARP-1 inhibitors. Docked conformation obtained for each molecule was used as such for 3D-QSAR analysis. Molecules were divided into a training set and a test set randomly in four different ways, partial least square analysis was performed to obtain QSAR models using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). Derived models showed good statistical reliability that is evident from their r², q²(loo) and r²(pred) values. To obtain a consensus for predictive ability from all the models, average regression coefficient r²(avg) was calculated. CoMFA and CoMSIA models showed a value of 0.930 and 0.936, respectively. Information obtained from the best 3D-QSAR model was applied for optimization of lead molecule and design of novel potential inhibitors.

Severe Chest Wall Toxicity From Cryoablation in the Setting of Prior Stereotactic Ablative Radiotherapy.

Science.gov (United States)

Chaudhuri, Aadel A; Binkley, Michael S; Aggarwal, Sonya; Qian, Yushen; Carter, Justin N; Shah, Rajesh; Loo, Billy W

2016-02-02

We present the case of a 42-year-old woman with metastatic synovial sarcoma of parotid origin, treated definitively with chemoradiation, who subsequently developed oligometastatic disease limited to the lungs. She underwent multiple left and right lung wedge resections and left lower lobectomy, followed by right lower lobe stereotactic ablative radiotherapy (SABR), 54 Gy in three fractions to a right lower lobe lesion abutting the chest wall. Two years later, she was treated with cryoablation for a separate right upper lobe nodule abutting the chest wall. Two months later, she presented with acute shortness of breath, pleuritic chest pain, decreased peripheral blood O2 saturation, and productive cough. A computed tomography (CT) scan demonstrated severe chest wall necrosis in the area of recent cryoablation that, in retrospect, also received a significant radiation dose from her prior SABR. This case demonstrates that clinicians should exercise caution in using cryoablation when treating lung tumors abutting a previously irradiated chest wall. Note: Drs. Loo and Shah contributed equally as co-senior authors.

Design and Calculation of an Earth Electrode

CERN Document Server

Gómez, J

2000-01-01

People using electrical installations have to be protected against electrical shock. For purposes of protection a distinction is made between direct and indirect contact. Direct contact is contact with a live conductor. Protection is provided by the insulation of cables or the screening of live parts. An indirect contact happens when someone touches exposed metal parts which are not intended to carry current but have become live as a result of a fault. In this case metallic parts raise the metal to a dangerous potential (contact voltage). Here protection is provided by connecting the exposed metal part (i.e. the case of the electrical machine) to the earthing point of the installation. A protective device will disconnect the circuit as soon as a fault current flows to earth. The earth fault value will depend on the impedance of the path taken by the fault current, which is known as the earth fault loop. The resistance of the earth electrode plays an important role in the final impedance of the earth fault loo...

Optimal bounds and extremal trajectories for time averages in dynamical systems

Science.gov (United States)

Tobasco, Ian; Goluskin, David; Doering, Charles

2017-11-01

For systems governed by differential equations it is natural to seek extremal solution trajectories, maximizing or minimizing the long-time average of a given quantity of interest. A priori bounds on optima can be proved by constructing auxiliary functions satisfying certain point-wise inequalities, the verification of which does not require solving the underlying equations. We prove that for any bounded autonomous ODE, the problems of finding extremal trajectories on the one hand and optimal auxiliary functions on the other are strongly dual in the sense of convex duality. As a result, auxiliary functions provide arbitrarily sharp bounds on optimal time averages. Furthermore, nearly optimal auxiliary functions provide volumes in phase space where maximal and nearly maximal trajectories must lie. For polynomial systems, such functions can be constructed by semidefinite programming. We illustrate these ideas using the Lorenz system, producing explicit volumes in phase space where extremal trajectories are guaranteed to reside. Supported by NSF Award DMS-1515161, Van Loo Postdoctoral Fellowships, and the John Simon Guggenheim Foundation.

Francois Loos is presenting a policy bill setting the framework, the phrasing and the resources of the radioactive materials and wastes management

International Nuclear Information System (INIS)

2006-01-01

The bill institutes a national radioactive materials and waste management plan and defines a programme and calendar for research and work leading to implementation of this plan, which will comprise three major points: with a view to looking to reduce the quantity of waste, spent nuclear fuels taken from the nuclear power plants will be reprocessed for recycling in the plants; waste which cannot be recycled will be packaged in a robust matrix and then temporarily stored on the surface; after interim storage, waste which cannot be finally disposed of in a surface facility, will be placed in a deep geological reversible repository. In order to monitor each step in this plan, the bill strengthens independent assessment of research and involves greater information of the public. With regard to financing, the bill clarifies the fact that economic development of the departments concerned by research into disposal options and the research itself will be financed by additional taxes on the operators of nuclear installations. (A.L.B.)

3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models

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Swetha Gade

2012-01-01

Full Text Available Objective: Monocyte chemo attractant protein-1 (MCP-1 is a member of the CC-chemokine family and it selectively recruits leukocytes from the circulation to the site of inflammation through binding with the chemotactic cytokine receptor 2B (CCR2B. The recruitment and activation of selected populations of leukocytes is a key feature in a variety of inflammatory conditions. Thus MCP-1 receptor antagonist represents an attractive target for drug discovery. To understand the structural requirements that will lead to enhanced inhibitory potencies, we have carried out 3D-QSAR (quantitative structure-activity relationship studies on (R-3-aminopyrrolidine series of molecules as CCR2B receptor antagonists. Materials and Methods: Comparative molecular field analysis (CoMFA and comparative molecular similarity indices analysis (CoMSIA were performed on a series of (R-3-aminopyrrolidine derivatives as antagonists of CCR2B receptor with Sybyl 6.7v. Results: We have derived statistically significant model from 37 molecules and validated it against an external test set of 13 compounds. The CoMFA model yielded a leave one out r 2 (r 2 loo of 0.847, non-cross-validated r 2 (r 2 ncv of 0.977, F value of 267.930, and bootstrapped r 2 (r 2 bs of 0.988. We have derived the standard error of prediction value of 0.367, standard error of estimate 0.141, and a reliable external predictivity, with a predictive r 2 (r 2 pred of 0.673. While the CoMSIA model yielded an r 2 loo of 0.719, r 2 ncv of 0.964,F value of 135.666, r 2 bs of 0.975, standard error of prediction of 0.512, standard error of estimate of 0.180, and an external predictivity with an r 2 pred of 0.611. These validation tests not only revealed the robustness of the models but also demonstrated that for our models r 2 pred, based on the mean activity of test set compounds can accurately estimate external predictivity. Conclusion: The QSAR model gave satisfactory statistical results in terms of q 2 and r 2

30 July 2012 - Prime Minister of France, Mr. Jean-Marc Ayrault, visits CERN

CERN Multimedia

Maximillien Brice

2012-01-01

Ligne d'accueil: Directeur général, R. Heuer présente: Directeur S. Myers, Chef des Relations internationales F. Pauss et Chefs de Département P. Bloch et A.-S. Catherin ; Représentants du CEA et du CNRS des 4 experiences LHC : J.-L. Faure, L. Fayard, C. Guyot, M.-H. Schune, Y. Schutz, Y. Sirois, Protocole CERN S. Molinari. Les autorités locales saluent le Premier ministre: M. Christophe Bouvier, maire de Cessy, M. Rachel Mazuir, sénateur de l'Ain, président du CG01, M. Etienne Blanc, député de l'Ain, maire de Divonne les Bains, et Mme Yvette Brachet, conseillère régionale représentant M. Jean-Jack Queyranne, président du CR Rhône Alpes. CERN-GE-1207163 32: dans le tunnel du LHC au Point 5: R. Garoby, Chef adjoint du département Faisceaux P. Lebrunm, Attaché à la Direction P. Bloch, Chef du département Physique J. Bertrand, (représente Alain Fuchs),CNRS Y. Sirois, Collaboration CMS, Responsable pour la France, Directeur de Recherche au CNRS, LLR Ecole Polytechnique J.-Y. Le Deaut, Dépu...

Relativité et gravitation

CERN Document Server

Tourrenc, Philippe

1992-01-01

La relativité générale a cessé d'être une pure théorie justifiée par les "trois tests classiques" disponibles il y a trente ans. Des pulsars, vrais laboratoires de gravitation relativiste, ont été découverts et étudiés. A l'automne 1991 les Etats-Unis ont pris la décision de construire deux détecteurs interférométriques d'ondes gravitationnelles. Au début de l'été 1992, le ministre français de la Recherche et de l'Espace a pris un engagement de même nature concernant le projet VIRGO, projet franco-italien de construction d'une antenne interférométrique. La gravitation relativiste est devenue un riche domaine d'observation et d'expérimentation. Cet ouvrage est un manuel de physique dont les intentions et le contenu se veulent adaptés au contexte scientifique actuel. Il doit beaucoup aux divers enseignements donnés par l'auteur, principalement l'enseignement de relativité générale en maîtrise de physique à l'université Pierre et Marie Curie (Paris VI). Dans la première partie, l...

The ministers of the Concertación de Partidos por la Democracia in Chile. An analysis of their political, social and cultural capital

Directory of Open Access Journals (Sweden)

Hernán CUEVAS

2015-12-01

Full Text Available In this article we analyze the political trajectories of 106 former ministers (of a total of 143 who held office during the governments of the Concertación de Partidos por la Democracia between 1990 and 2010. Based on a survey applied to this total, we first measured the political, social and cultural capital of each individual, then calculated each capital’s effect on the probability of individuals becoming a minister of a political, a social or an economic Ministry. Different from other recent studies of the Chilean elite that emphasize its socialization and sociological features, here we constructed separate indices of political capital, social capital and cultural capital to measure and explain how «ministrable» politicians become ministers. Each index has been standardized for the sake of cross-comparison. We conclude that despite the relevance given to technical expertise over politics, political capital is the factor that has the most influence on the probability of individuals becoming ministers of political, social or economic Ministries. Through a logistic regression model and a survival analysis model, we demonstrated that, although academic formation and social background seem relevant, these aspects are less determinant than the political trajectories of individuals, which demonstrated the most robust predictor of becoming a minister.

Fostering future organization of French Electric Power. A report to Prime Minister; Reussir la future organisation electrique francaise. Rapport au Premier Ministre

Energy Technology Data Exchange (ETDEWEB)

Dumont, Jean Louis [Assemblee Nationale, Paris (France)

1998-07-02

This report addressed to the prime minister deals with the main four issues relating to the problem of revamping the French electricity sector. These are featured as: 1. The public electricity supply; 2. The future development of 'Electricite de France'; 3. The social renovation of the electricity sector; 4. Management and the role of policy. In turn these four chapters are detailed. Thus the first one addresses the problems: 1. Customizing the general interest supply; 2. Electricity general supply and the state policy; 3. Sustaining innovation, environmental protection and energy management; 4. The transport and distribution grid, the resistance structure of the public supply. Also, this chapter describes the role of the operators in the public electricity supply and tackles the problem of financing the commitments of the public supply. The second chapter sketches the tasks and management of EDF, considers establishing an agency to ensure accounting transparency, discusses the major significance of local collectivities and personnel. The third chapter addresses the following issues: 1. The range of application of the statute of electric and gas industries; 2. Adaptation of the statute; 3. Development of the statute; 4. Pensioners. The forth chapter deals with the definition of regulation, i.e. the management of the network authority and makes proposals for constituting relating commissions. In conclusion, the author pleads for maintaining and developing a major national operator ensuring public supply requirements as well as promotion of French electricity industry. The proposals made by the report's author concerning the operational ways of renewing the nuclear sector, the management of grid of electric transport, the role of local collectivities, creation of a professional trade, the founding regulation commissions and others are thought to prepare France to cope efficiently to the international competition in the years to come. The report is completed by two appendices containing the proposals of the author and a list of the persons interviewed during the mission.

Hycycle. The feasibility of the introduction of the hydrogen bicycle to the Dutch citizen to promote social acceptance of the hydrogen economy; Hycycle. De haalbaarheid van de introductie van de waterstoffiets aan de Nederlandse burger ter bevordering van de maatschappelijke acceptatie van de waterstofeconomie

Energy Technology Data Exchange (ETDEWEB)

Makkus, R.C. [ECN Brandstofcel Technologie, Petten (Netherlands); Van Hoeven, K. [Van Hoeven Consult, Beuningen (Netherlands); Bastianen, H. [Sparta, Apeldoorn (Netherlands); D' Herripon, B. [IDbike, Goirle (Netherlands); Smolenaars, J.; Westendorp, G. [Hexion, Arnhem (Netherlands); De Wit, H. [Hoek Loos, Schiedam (Netherlands)

2005-04-01

A feasibility study has been carried out to develop a pedal assisted bicycle for which the required electrical energy is supplied by a PEM Fuel Cell system, the 'hycycle'. The bicycle is based on the existing electric Sparta Ion bicycle. It is concluded that such a 'hycycle' is technically and economically feasible, if the PEM Fuel Cell system is produced on a large scale. However, technical developments are needed before entering into a demonstration project. [Dutch] Hycycle is het concept van een waterstoffiets, gebaseerd op de bestaande elektrische Sparta Ion fiets. Hycycle wordt een trapbekrachtigde fiets die de benodigde (elektrische) energie uit waterstof haalt middels een brandstofcelsysteem. Hycycle is een haalbaarheidsstudie in her kader van het onderzoek naar transitiemogelijkheden naar een duurzame energiehuishouding in Nederland. Deze studie wordt verricht door een coalitie van Sparta, IDbike, ECN, Hexion, Hoek Loos en Van Hoeven Consult. Het project is uitgevoerd in de periode augustus 2004 tot en met februari 2005. Het doel van het onderzoek is om de haalbaarheid na te gaan van een praktisch demonstratieproject in Nederland van het gebruik van de waterstoffiets.

Seed oil triglyceride profiling of thirty-two hybrid grape varieties.

Science.gov (United States)

De Marchi, Fabiola; Seraglia, Roberta; Molin, Laura; Traldi, Pietro; De Rosso, Mirko; Panighel, Annarita; Dalla Vedova, Antonio; Gardiman, Massimo; Giust, Mirella; Flamini, Riccardo

2012-09-01

Triglyceride profile of seed oil samples from 32 hybrid grape varieties not studied before was investigated. A new method for the analysis of triacylglycerols (TAGs) has been developed based on the direct infusion in the electrospray ionization (ESI) source and employing tetrahydrofuran/methanol/water (85:10:5 v|v|v) as solvent; the formation of [M + Na](+) ions in high yield has been observed. TAGs were identified by ESI-tandem mass spectrometry analysis, and the matrix-assisted-laser-desorption-ionization and time-of-flight profile of samples was determined. Six were the principal TAGs identified in seed oil: trilinolein (LLL) was the most abundant (43%), followed by dilinoleoyl-oleoylglycerol (LOL, 23%), and dilinoleoyl-palmitoylglycerol (LPL, 15%). Compounds present in lower concentration were LSL and LOO (11%), LOP (6%), and LSP (2%). Compared with seed oils produced from V. Vinifera grapes, some significant differences in the relative abundances of TAGs were found, in particular hybrid grape seed oils showed higher LOL and lower LPL content, respectively. Among the samples studied, a particularly high content of LLL (rich in unsaturated fatty acids) was found in seed oils from two red varieties. Copyright © 2012 John Wiley & Sons, Ltd.

A step towards PACS: The DS-1000 traumatology

International Nuclear Information System (INIS)

Schmidt, C.; Deininger, H.K.

1989-01-01

The development of new technologies is changing more and more the medical diagnostic. Analogous procedures are consistently making way for digital methods. 1980, the number of digital procedures amounted to 15%; 1990 according to general estimation, the number will already amount to 50%. It appears significant, within the framework of a new course, to promote the digitalisation not only in technical procedures but also in the organisation area. A central Picture Archiving and Communication System (PACS) is today considered an ideal solution, provided that the complete diagnostic imaging is carried out digitally. In the submitted is a report on a digital working unit for trauma patients. The initial results demonstrate that this concept is more than a promising attempt to replace conventional bone diagnostic in the future. The system presented is capable of demonstrations all clinically relevant changes of the traumatic skeleton, whereby the image quality corresponds approximately to a high-speed film-screen combination. Among the advantages, it should be emphasized in particular, the reduction in radiation, the rapid display of examination results and the integration in a Picture Archiving and Communication System (PACS) without any loos of information. (orig.) [de

Structural insights of Staphylococcus aureus FtsZ inhibitors through molecular docking, 3D-QSAR and molecular dynamics simulations.

Science.gov (United States)

Ballu, Srilata; Itteboina, Ramesh; Sivan, Sree Kanth; Manga, Vijjulatha

2018-02-01

Filamentous temperature-sensitive protein Z (FtsZ) is a protein encoded by the FtsZ gene that assembles into a Z-ring at the future site of the septum of bacterial cell division. Structurally, FtsZ is a homolog of eukaryotic tubulin but has low sequence similarity; this makes it possible to obtain FtsZ inhibitors without affecting the eukaryotic cell division. Computational studies were performed on a series of substituted 3-arylalkoxybenzamide derivatives reported as inhibitors of FtsZ activity in Staphylococcus aureus. Quantitative structure-activity relationship models (QSAR) models generated showed good statistical reliability, which is evident from r 2 ncv and r 2 loo values. The predictive ability of these models was determined and an acceptable predictive correlation (r 2 Pred ) values were obtained. Finally, we performed molecular dynamics simulations in order to examine the stability of protein-ligand interactions. This facilitated us to compare free binding energies of cocrystal ligand and newly designed molecule B1. The good concordance between the docking results and comparative molecular field analysis (CoMFA)/comparative molecular similarity indices analysis (CoMSIA) contour maps afforded obliging clues for the rational modification of molecules to design more potent FtsZ inhibitors.

QSPR models of n-octanol/water partition coefficients and aqueous solubility of halogenated methyl-phenyl ethers by DFT method.

Science.gov (United States)

Zeng, Xiao-Lan; Wang, Hong-Jun; Wang, Yan

2012-02-01

The possible molecular geometries of 134 halogenated methyl-phenyl ethers were optimized at B3LYP/6-31G(*) level with Gaussian 98 program. The calculated structural parameters were taken as theoretical descriptors to establish two new novel QSPR models for predicting aqueous solubility (-lgS(w,l)) and n-octanol/water partition coefficient (lgK(ow)) of halogenated methyl-phenyl ethers. The two models achieved in this work both contain three variables: energy of the lowest unoccupied molecular orbital (E(LUMO)), most positive atomic partial charge in molecule (q(+)), and quadrupole moment (Q(yy) or Q(zz)), of which R values are 0.992 and 0.970 respectively, their standard errors of estimate in modeling (SD) are 0.132 and 0.178, respectively. The results of leave-one-out (LOO) cross-validation for training set and validation with external test sets both show that the models obtained exhibited optimum stability and good predictive power. We suggests that two QSPR models derived here can be used to predict S(w,l) and K(ow) accurately for non-tested halogenated methyl-phenyl ethers congeners. Copyright © 2011 Elsevier Ltd. All rights reserved.

Healing the Empire: Indian Hospitals in Britain and France during the First World War.

Science.gov (United States)

Jarboe, Andrew Tait

2015-01-01

Desperate for soldiers to stem the German onrush in late 1914, the British deployed some 135,000 Indian riflemen--known as sepoys--to the trenches of France and Belgium. Between October 1914 and December 1915, these soldiers fought at the battles of Ypres, Festubert, Givenchy, Neuve Chapelle, Second Ypres, and Loos, suffering some 34,252 casualties. This article looks to the experiences of these men at segregated hospitals in France and England from 1914 to 1915. These hospitals served many of the same dual purposes facilitated by hospitals for English soldiers: namely, they sustained the war-making capacity of the Indian battalions. The Indian hospitals also functioned as sites of propaganda, reaffirming the ideologies and racial hierarchies of imperial rule for audiences at home, abroad, and within the hospital wards. But as this article demonstrates, wounded Indian sepoys were rarely, if ever, mere pawns on the imperial chessboard. Hospital authorities were committed to two policies: returning sepoys to the front and protecting White prestige. Sepoys successfully resisted both. In so doing, Indian hospitals became what British hospital administrators hoped they would not: spaces where imperial subjects contested and even reshaped some of the policies and ideologies of imperial rule.

Development and validation of a multiplex reaction analyzing eight miniSTRs of the X chromosome for identity and kinship testing with degraded DNA.

Science.gov (United States)

Castañeda, María; Odriozola, Adrián; Gómez, Javier; Zarrabeitia, María T

2013-07-01

We report the development of an effective system for analyzing X chromosome-linked mini short tandem repeat loci with reduced-size amplicons (less than 220 bp), useful for analyzing highly degraded DNA samples. To generate smaller amplicons, we redesigned primers for eight X-linked microsatellites (DXS7132, DXS10079, DXS10074, DXS10075, DXS6801, DXS6809, DXS6789, and DXS6799) and established efficient conditions for a multiplex PCR system (miniX). The validation tests confirmed that it has good sensitivity, requiring as little as 20 pg of DNA, and performs well with DNA from paraffin-embedded tissues, thus showing potential for improved analysis and identification of highly degraded and/or very limited DNA samples. Consequently, this system may help to solve complex forensic cases, particularly when autosomal markers convey insufficient information.

Towards A New Reading of the Political Thought of the Dévot Faction: The Opposition to Cardinal Richelieu’s Ministériat

Directory of Open Access Journals (Sweden)

Caroline Maillet-Rao

2013-10-01

Full Text Available For a long time, historiography has considered the political thought of the dévot party, led by Mathieu de Morgues and Michel de Marillac, to be supportive of a traditional monarchy, Catholicism and the extermination of Protestants, while being opposed to the Thirty Years War. This faction’s political thought has been looked upon as being in contrast to that of Cardinal Richelieu, which was comparatively regarded as profoundly absolutist and modern. Such an understanding of the dévots’ political thought, albeit disputed, continues to prevail. The present article intends to demonstrate that the dévots were in fact on the side of the absolutists, which explains their opposition to Richelieu. Indeed, they never criticized absolutism, but rather, the illegitimate leadership of the government by an all-powerful premier ministre, namely, Richelieu. According to the dévots, the ministériat actually betrayed the very essence of absolute monarchy. Before proposing a new perspective on its political thought, it is important to reflect upon the definition of the dévot party. This will be followed by an overview of the lives and work of the principal representatives of this faction, Mathieu de Morgues (1582–1670 and Michel de Marillac (1560–1632. An examination of the historiography on this subject enables this article’s conclusions to be situated in a broader context.

Eesti-Taani suhete õiguslikke, poliitilisi ja majanduslikke aspekte 1940-1995 : [bakalaureusetöö] / Jürgo Loo ; Tartu Ülikool, õigusteaduskond ; juhendaja: Peeter Järvelaid

Index Scriptorium Estoniae

Loo, Jürgo

1995-01-01

Taani poliitika Balti riikide NSV Liitu inkorporeerimise küsimuses ja Eesti-Taani vahelised suhted Eesti iseseisvuse taastamise eelsel perioodil, Eesti-Taani poliitilised suhted pärast Eesti iseseisvuse taastamist, Eesti-Taani majandussuhted, lepinguliste suhete areng

Symmetry Analysis of Gait between Left and Right Limb Using Cross-Fuzzy Entropy

Directory of Open Access Journals (Sweden)

Yi Xia

2016-01-01

Full Text Available The purpose of this paper is the investigation of gait symmetry problem by using cross-fuzzy entropy (C-FuzzyEn, which is a recently proposed cross entropy that has many merits as compared to the frequently used cross sample entropy (C-SampleEn. First, we used several simulation signals to test its performance regarding the relative consistency and dependence on data length. Second, the gait time series of the left and right stride interval were used to calculate the C-FuzzyEn values for gait symmetry analysis. Besides the statistical analysis, we also realized a support vector machine (SVM classifier to perform the classification of normal and abnormal gaits. The gait dataset consists of 15 patients with Parkinson’s disease (PD and 16 control (CO subjects. The results show that the C-FuzzyEn values of the PD patients’ gait are significantly higher than that of the CO subjects with a p value of less than 10-5, and the best classification performance evaluated by a leave-one-out (LOO cross-validation method is an accuracy of 96.77%. Such encouraging results imply that the C-FuzzyEn-based gait symmetry measure appears as a suitable tool for analyzing abnormal gaits.

Simulation of the aspersion system of the core low pressure (LPCS) for a boiling water reactor (BWR) based on RELAP

International Nuclear Information System (INIS)

Membrillo G, O. E.; Chavez M, C.

2012-10-01

The present work presents the modeling and simulation of the aspersion system to low pressure of reactor of the nuclear power plant of Laguna Verde using the nuclear code RELAP/SCDAP. The objective of the emergency systems inside a nuclear reactor is the cooling of the core, nor caring the performance of any other emergency system in the case of an accident design base for coolant loss. To obtain a simulation of the system is necessary to have a model based on their main components, pipes, pumps, valves, etc. This article describes the model for the simulation of the main line and the test line for the HPCS. At the moment we have the simulation of the reactor vessel and their systems associated to the nuclear power plant of Laguna Verde, this work will allow to associate the emergency system model LPCS to the vessel model. The simulation of the vessel and the emergency systems will allow knowing the behavior of the reactor in the stage of the coolant loos, giving the possibility to analyze diverse scenarios. The general model will provide an auxiliary tool for the training in classroom and at distance in the operation of nuclear power plants. (Author)

Simulation of the aspersion system of the core low pressure (LPCS) for a boiling water reactor (BWR) based on RELAP; Simulacion del sistema de aspersion del nucleo a baja presion (LPCS) para un reactor de agua en ebullicion (BWR) basado en RELAP

Energy Technology Data Exchange (ETDEWEB)

Membrillo G, O. E.; Chavez M, C., E-mail: garzo1012@gmail.com [UNAM, Facultad de Ingenieria, Circuito Interior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)

2012-10-15

The present work presents the modeling and simulation of the aspersion system to low pressure of reactor of the nuclear power plant of Laguna Verde using the nuclear code RELAP/SCDAP. The objective of the emergency systems inside a nuclear reactor is the cooling of the core, nor caring the performance of any other emergency system in the case of an accident design base for coolant loss. To obtain a simulation of the system is necessary to have a model based on their main components, pipes, pumps, valves, etc. This article describes the model for the simulation of the main line and the test line for the HPCS. At the moment we have the simulation of the reactor vessel and their systems associated to the nuclear power plant of Laguna Verde, this work will allow to associate the emergency system model LPCS to the vessel model. The simulation of the vessel and the emergency systems will allow knowing the behavior of the reactor in the stage of the coolant loos, giving the possibility to analyze diverse scenarios. The general model will provide an auxiliary tool for the training in classroom and at distance in the operation of nuclear power plants. (Author)

Salient aspects of PBP2A-inhibition; A QSAR Study.

Science.gov (United States)

Ogunleye, Adewale J; Eniafe, Gabriel O; Inyang, Olumide K; Adewumi, Benjamin; Omotuyi, Olaposi I

2018-05-15

Backgound: Inhibition of penicillin binding protein 2A (PBP2A) represents a sound drug design strategy in combatting Methicillin resistant Staphylococcus aureus (MRSA). Considering the urgent need for effective antimicrobials in combatting MRSA infections, we have developed a statistically robust ensemble of molecular descriptors (1, 2, & 3-D) from compounds targeting PBP2A in vivo. 37 (training set: 26, test set: 11) PBP2A-inhibitors were submitted for descriptor generation after which an unsupervised, non-exhaustive genetic algorithm (GA) was deployed for fishing out the best descriptor subset. Assignment of descriptors to a regression model was accomplished with the Partial Least Square (PLS) algorithm. At the end, an ensemble of 30 descriptors accurately predicted the ligand bioactivity, IC50 (R = 0.9996, R2 = 0.9992, R2a = 0.9949, SEE =, 0.2297 Q2LOO = 0.9741). Inferentially, we noticed that the overall efficacy of this model greatly depends on atomic polarizability and negative charge (electron) density. Besides the formula derived, the high dimensional model also offers critical insights into salient cheminformatics parameter to note during hit-to-lead PBP2A-antagonist optimization. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

An FFAG-ERL at Cornell University for eRHIC prototyping and bright-beam applications

Energy Technology Data Exchange (ETDEWEB)

Hoffstaetter, Georg [Cornell University, Ithaca, NY (United States)

2016-07-01

Cornell University has prototyped technology essential for any high-brightness electron ERL. This includes a DC gun and an SRF injector Linac with world-record current and normalized brightness in a bunch train, a high-current CW cryomodule for 70 MeV energy gain, a high-power beam stop, and several diagnostics tools for high-current and high-brightness beams, e.g. slid measurements for 6-D phase-space densities, a fast wire scanner for beam profiles, and beam loos diagnostics. All these are now available to equip a one-cryomodule ERL, and laboratory space has been cleared out and is radiation shielded to install this ERL at Cornell. BNL has designed a multi-turn ERL for eRHIC, where beam is transported more than 20 times around the RHIC tunnel. The number of transport lines is minimized by using two non-scaling (NS) FFAG arcs. A collaboration between BNL and Cornell has been formed to investigate the new NS-FFAG optics and the multi-turn eRHIC ERL design by building a 4-turn, one-cryomodule ERL at Cornell. It has a NS-FFAG return loop built with permanent magnets and is meant to accelerate 40 mA beam to 250 MeV.

Arhitektuurivõistlused 2008 / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2008-01-01

Võistluste tulemused: Pekingi saatkonnahoone: I preemia - A. Põime, L. Põime, L. Vaimel; Riia saatkonnahoone: I - L.-K. Stöör, Ü.-T. Stöör, H. Urb; Eesti Kunstiakadeemia uus õppehoone: I - SEA + Effekt (Taani); Eesti Maaülikooli Kreutzwaldi 5 õppehoone juurdeehitis: I - P. Loo, J. Skolimowski, L. Vene, K. Kruuse (KAMP Arhitektid); TÜ Viljandi Kultuuriakadeemia loomeinkubaatori ja lavakunstide õppehoone: I - S. Vallner, H. Urb, I. Peil, H. Lass, S.-M. Mändmaa (Kavakava); Tamula järve ranna-ala mahuline planeering: I - K. Enno, L. Luhse, M. Zeleznova, R. Ailt (K. Enno Arhitektuuribüroo); Tartu pärmivabriku kvartali arhitektuurivõistlus: võidutöö - Atelier Thomas Pucher / Bramberger Architects (Austria); Paldiski mnt. 50 kinnistu ja lähiala: I-II - T. Laigu, K. Ojaliiv, M. Rass, A. Uukado (QP Arhitektid); maastikuarhitektuuri võistlus "Eesti Maaülikooli Tähtvere linnaku välialad": I - H. Runnel, T. Ong; Tartu rahu tähisala kujundus: I - M. Kinks, K. Süda; Veneetsia XI rahvusvahelise arhitektuuribiennaali ideekavandi võistlus: I - M. Kask, R. Lõoke, N. Külm; aasta betoonehitis 2007 - Puurmani kaarsild, konstruktorid S. Idnurm, J. Idnurm; Eesti parim puitehitis 2008: eramu Loobul - R. Vaiksoo; võistluse "Eramu 2006-2007" peapreemia: villa Paldiskis - S. Vallner, I. Peil

Predictive QSAR Models for the Toxicity of Disinfection Byproducts

Directory of Open Access Journals (Sweden)

Litang Qin

2017-10-01

Full Text Available Several hundred disinfection byproducts (DBPs in drinking water have been identified, and are known to have potentially adverse health effects. There are toxicological data gaps for most DBPs, and the predictive method may provide an effective way to address this. The development of an in-silico model of toxicology endpoints of DBPs is rarely studied. The main aim of the present study is to develop predictive quantitative structure–activity relationship (QSAR models for the reactive toxicities of 50 DBPs in the five bioassays of X-Microtox, GSH+, GSH−, DNA+ and DNA−. All-subset regression was used to select the optimal descriptors, and multiple linear-regression models were built. The developed QSAR models for five endpoints satisfied the internal and external validation criteria: coefficient of determination (R2 > 0.7, explained variance in leave-one-out prediction (Q2LOO and in leave-many-out prediction (Q2LMO > 0.6, variance explained in external prediction (Q2F1, Q2F2, and Q2F3 > 0.7, and concordance correlation coefficient (CCC > 0.85. The application domains and the meaning of the selective descriptors for the QSAR models were discussed. The obtained QSAR models can be used in predicting the toxicities of the 50 DBPs.

Probing the biocompatibility of MoS2 nanosheets by cytotoxicity assay and electrical impedance spectroscopy

Science.gov (United States)

Shah, Pratikkumar; Narayanan, Tharangattu N.; Li, Chen-Zhong; Alwarappan, Subbiah

2015-08-01

Transition metal dichalgogenides such as MoS2 have recently emerged as hot two-dimensional (2D) materials due to their superior electronic and catalytic properties. Recently, we have reported the usefulness of MoS2 nanosheets toward the electrochemical detection of neurotransmitters and glucose (Narayanan et al 2014 Nanotechnology 25 335702). Furthermore, there are reports available in the literature that demonstrate the usefulness of MoS2 nanosheets for biosensing and energy storage applications (Zhu et al 2013 J. Am. Chem. Soc. 135 5998-6001 Pumera and Loo 2014 Trends Anal. Chem. 61 49-53 Lee et al 2014 Sci. Rep. 4 7352; Stephenson et al 2014 Energy Environ. Sci. 7 209-31). Understanding the cytotoxic effect of any material is very important prior to employing them for any in vivo biological applications such as implantable sensors, chips, or carriers for drug delivery and cell imaging purposes. Herein, we report the cytotoxicity of the MoS2 nanosheets based on the cytotoxic assay results and electrical impedance analysis using rat pheochromocytoma cells (PC12) and rat adrenal medulla endothelial cells (RAMEC). Our results indicated that the MoS2 nanosheets synthesized in our work are safe 2D nanosheets for futuristic biomedical applications.

Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies.

Science.gov (United States)

Patel, Dhilon S; Bharatam, Prasad V

2008-05-01

In the development of drugs targeted for GSK-3, its selective inhibition is an important requirement owing to the possibility of side effects arising from other kinases for the treatment of diabetes mellitus. A three-dimensional quantitative structure-activity relationship study (3D-QSAR) has been carried out on a set of pyrazolo[3,4-b]pyrid[az]ine derivatives, which includes non-selective and selective GSK-3 inhibitors. The CoMFA models were derived from a training set of 59 molecules. A test set containing 14 molecules (not used in model generation) was used to validate the CoMFA models. The best CoMFA model generated by applying leave-one-out (LOO) cross-validation study gave cross-validation r(cv)(2) and conventional r(conv)(2) values of 0.60 and 0.97, respectively, and r(pred)(2) value of 0.55, which provide the predictive ability of model. The developed models well explain (i) the observed variance in the activity and (ii) structural difference between the selective and non-selective GSK-3 inhibitors. Validation based on the molecular docking has also been carried out to explain the structural differences between the selective and non-selective molecules in the given series of molecules.

Predictive QSAR Models for the Toxicity of Disinfection Byproducts.

Science.gov (United States)

Qin, Litang; Zhang, Xin; Chen, Yuhan; Mo, Lingyun; Zeng, Honghu; Liang, Yanpeng

2017-10-09

Several hundred disinfection byproducts (DBPs) in drinking water have been identified, and are known to have potentially adverse health effects. There are toxicological data gaps for most DBPs, and the predictive method may provide an effective way to address this. The development of an in-silico model of toxicology endpoints of DBPs is rarely studied. The main aim of the present study is to develop predictive quantitative structure-activity relationship (QSAR) models for the reactive toxicities of 50 DBPs in the five bioassays of X-Microtox, GSH+, GSH-, DNA+ and DNA-. All-subset regression was used to select the optimal descriptors, and multiple linear-regression models were built. The developed QSAR models for five endpoints satisfied the internal and external validation criteria: coefficient of determination ( R ²) > 0.7, explained variance in leave-one-out prediction ( Q ² LOO ) and in leave-many-out prediction ( Q ² LMO ) > 0.6, variance explained in external prediction ( Q ² F1 , Q ² F2 , and Q ² F3 ) > 0.7, and concordance correlation coefficient ( CCC ) > 0.85. The application domains and the meaning of the selective descriptors for the QSAR models were discussed. The obtained QSAR models can be used in predicting the toxicities of the 50 DBPs.

Automatic Samples Selection Using Histogram of Oriented Gradients (HOG Feature Distance

Directory of Open Access Journals (Sweden)

Inzar Salfikar

2018-01-01

Full Text Available Finding victims at a disaster site is the primary goal of Search-and-Rescue (SAR operations. Many technologies created from research for searching disaster victims through aerial imaging. but, most of them are difficult to detect victims at tsunami disaster sites with victims and backgrounds which are look similar. This research collects post-tsunami aerial imaging data from the internet to builds dataset and model for detecting tsunami disaster victims. Datasets are built based on distance differences from features every sample using Histogram-of-Oriented-Gradient (HOG method. We use the longest distance to collect samples from photo to generate victim and non-victim samples. We claim steps to collect samples by measuring HOG feature distance from all samples. the longest distance between samples will take as a candidate to build the dataset, then classify victim (positives and non-victim (negatives samples manually. The dataset of tsunami disaster victims was re-analyzed using cross-validation Leave-One-Out (LOO with Support-Vector-Machine (SVM method. The experimental results show the performance of two test photos with 61.70% precision, 77.60% accuracy, 74.36% recall and f-measure 67.44% to distinguish victim (positives and non-victim (negatives.

Report for the Prime Minister. Making the future French electric power organization a success; Rapport au Premier Ministre. Reussir la future organisation electrique francaise

Energy Technology Data Exchange (ETDEWEB)

Dumont, J L

1999-12-31

This report from the French Deputy of the Meuse region aims at taking stock of four main questions raised by the future organization of the French electric power industry in the context of the opening of the European power market: the public utility of electric power, the future missions of Electricite de france (EdF) company, the questions in relation with the personnel status in the electric power industry, and the status of the regulating authority. In order to give some elements of answer to these questions, the report has been divided into 2 parts: part 1 presents the power production, transport and distribution in the future electric power regulation (the renewal of nuclear facilities, the building of non-nuclear units, the exploitation of the power distribution network, the accounting dissociation and the transparency of accountancy, the organization of network access, the eligible clients, the direct power lines, the obligations of purchase, the distribution and the role of local authorities). Part 2 presents the four main stakes of the modernization of the French electric power sector: the electric power public utility (public concern and rights, government policy, sustain of innovation, environment protection and energy mastery, the transportation and distribution networks, the role of operators and the financing), the future evolution of EdF (missions and organization, future of the public company), the social modernization of the electric power sector (present day status, adaptation, evolution, pensions), the organization and role of the future regulation authority. The propositions of the author are reported in the appendix. (J.S.)

Annexe 2. Lettre du ministre de la France d’outre-mer Marius Moutet au président du Conseil sur le caoutchouc d’Indochine

OpenAIRE

2014-01-01

Haut Commissariat de France en Indochine Le Conseiller Financier Secret Extraits d’une lettre de M. Valls en date du 20 mars 1953 J’avais raison de vous signaler les dangers que courait l’Union Douanière Indochinoise. Les travaux de la Conférence de Phnom-Penh, auxquels j’ai consacré presque tout mon temps, au cours des deux dernières semaines sont une nouvelle fois suspendus pour donner aux Délégations un délai de réflexion qui évitera peut-être de clôturer les débats orageux de cette confér...

Případ Karla Löbla. Ministr vlády České socialistické republiky tajným spolupracovníkem StB

Czech Academy of Sciences Publication Activity Database

Pernes, Jiří

2015-01-01

Roč. 26, č. 1 (2015), s. 64-82 ISSN 1804-1612 Institutional support: RVO:68378114 Keywords : Communist party of Czechoslovakia * Czechoslovak Socialist Party * Secret police * Agency network Subject RIV: AB - History

Diamond encapsulated photovoltaics for transdermal power delivery.

Science.gov (United States)

Ahnood, A; Fox, K E; Apollo, N V; Lohrmann, A; Garrett, D J; Nayagam, D A X; Karle, T; Stacey, A; Abberton, K M; Morrison, W A; Blakers, A; Prawer, S

2016-03-15

A safe, compact and robust means of wireless energy transfer across the skin barrier is a key requirement for implantable electronic devices. One possible approach is photovoltaic (PV) energy delivery using optical illumination at near infrared (NIR) wavelengths, to which the skin is highly transparent. In the work presented here, a subcutaneously implantable silicon PV cell, operated in conjunction with an external NIR laser diode, is developed as a power delivery system. The biocompatibility and long-term biostability of the implantable PV is ensured through the use of an hermetic container, comprising a transparent diamond capsule and platinum wire feedthroughs. A wavelength of 980 nm is identified as the optimum operating point based on the PV cell's external quantum efficiency, the skin's transmission spectrum, and the wavelength dependent safe exposure limit of the skin. In bench-top experiments using an external illumination intensity of 0.7 W/cm(2), a peak output power of 2.7 mW is delivered to the implant with an active PV cell dimension of 1.5 × 1.5 × 0.06 mm(3). This corresponds to a volumetric power output density of ~20 mW/mm(3), significantly higher than power densities achievable using inductively coupled coil-based approaches used in other medical implant systems. This approach paves the way for further ministration of bionic implants. Copyright © 2015 Elsevier B.V. All rights reserved.

Initial mandate concerning the problem of fluctuating gasoline prices and their effect on the Quebec economy : Final report

International Nuclear Information System (INIS)

Guillot, R.; Ford, N. ed.

2002-06-01

Over a three-year period covering May 1998 to May 2001, the average price of gasoline in Quebec slowly increased from 57.1 cent per litre to 82.6 cent per litre. This 45 per cent increase in the price of gasoline worried consumers and had an effect on commercial and industrial operations throughout the province. This situation prompted the Commission de l'economie et du travail (Commission on Labour and the Economy) to initiate a mandate to examine the problem. In October 2001, experts representing energy and taxation sectors were consulted and presentations made by 17 people and organizations. The Ministre des Ressources Naturelles (Minister of Natural Resources) and the President de la Regie de l'Energie were heard in a public consultation forum. In the first part of the document, the authors explained the mechanism by which the price of gasoline and its various components are determined, identified the elements responsible for the increases in prices, and compare the prices in the different parts of the province. In part two, the responsibilities and powers of the Ministry of Natural Resources and the Regie de l'Energie with regard to petroleum products were examined. Part three described the opinions expressed and proposed recommendations obtained during the public consultation process and they were grouped under four headings: taxation, competition, consumer information, and energy savings. The final part of the document presented the recommendations of the Commission on Labour and the Economy. 15 refs., 5 tabs

Intervention of Mr Nicolas Sarkozy, Government minister, minister of economy, finances and industry. Energy debate - Thursday April 15, 2004 - French house of commons; Intervention de M. Nicolas Sarkozy, ministre d'Etat, ministre de l'economie, des finances et de l'industrie. Debat sur l'energie - jeudi 15 avril 2004 - assemblee nationale

Energy Technology Data Exchange (ETDEWEB)

Sarkozy, N.

2004-04-01

In this talk, the French minister of economy, finances and industry recalls, first, some important key dates of the French energy history (creation of the French electric and gas utilities (EdF and GdF) in 1946, first petroleum shock in 1973 and the start-up of the French nuclear program) and then, presents the present day energy policy and the constraints that control the French energy choices: the lack of oil and gas resources in the French territory, and the problem of the global warming. According to these constraints, the French government has defined 4 main axes: energy mastery (thermal insulation of buildings, abatement of road speed limits, development of railway and river transport, financial incentives), development of renewable energy sources, renewal of the nuclear park with the launching of the European Pressurized reactor (EPR), and development of research programs in the domain of energy. The last part presents the new European framework of the French energy policy with the change of EdF and GdF juridical statuses and the progressive convergence of the different European energy policies towards a common model. (J.S.)

Molecular docking and 3D-QSAR studies on triazolinone and pyridazinone, non-nucleoside inhibitor of HIV-1 reverse transcriptase.

Science.gov (United States)

Sivan, Sree Kanth; Manga, Vijjulatha

2010-06-01

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of the HIV-1 reverse transcriptase. Recently a series of Triazolinone and Pyridazinone were reported as potent inhibitors of HIV-1 wild type reverse transcriptase. In the present study, docking and 3D quantitative structure activity relationship (3D QSAR) studies involving comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on 31 molecules. Ligands were built and minimized using Tripos force field and applying Gasteiger-Hückel charges. These ligands were docked into protein active site using GLIDE 4.0. The docked poses were analyzed; the best docked poses were selected and aligned. CoMFA and CoMSIA fields were calculated using SYBYL6.9. The molecules were divided into training set and test set, a PLS analysis was performed and QSAR models were generated. The model showed good statistical reliability which is evident from the r2 nv, q2 loo and r2 pred values. The CoMFA model provides the most significant correlation of steric and electrostatic fields with biological activities. The CoMSIA model provides a correlation of steric, electrostatic, acceptor and hydrophobic fields with biological activities. The information rendered by 3D QSAR model initiated us to optimize the lead and design new potential inhibitors.

Development of andrographolide loaded PLGA microspheres: optimization, characterization and in vitro-in vivo correlation.

Science.gov (United States)

Jiang, Yunxia; Wang, Fang; Xu, Hui; Liu, Hui; Meng, Qingguo; Liu, Wanhui

2014-11-20

The purpose of this study was to develop a sustained-release drug delivery system based on the injectable PLGA microspheres loaded with andrographolide. The andrographolide loaded PLGA microspheres were prepared by emulsion solvent evaporation method with optimization of formulation using response surface methodology (RSM). Physicochemical characterization, in vitro release behavior and in vivo pharmacokinetics of the optimized formulation were then evaluated. The percent absorbed in vivo was determined by deconvolution using the Loo-Riegelman method, and then the in vitro-in vivo correlation (IVIVC) was established. Results showed that the microspheres were spherical with a smooth surface. Average particle size, entrapment efficiency and drug loading were found to be 53.18±2.11 μm, 75.79±3.02% and 47.06±2.18%, respectively. In vitro release study showed a low initial burst release followed by a prolonged release up to 9 days and the release kinetics followed the Korsmeyer-Peppas model. After a single intramuscular injection, the microspheres maintained relatively high plasma concentration of andrographolide over one week. A good linear relationship was observed between the in vitro and in vivo release behavior (R(2)=0.9951). These results suggest the PLGA microspheres could be developed as a potential delivery system for andrographolide with high drug loading capacity and sustained drug release. Copyright © 2014 Elsevier B.V. All rights reserved.

Management of Candida infections in liver transplant recipients: current perspectives

Directory of Open Access Journals (Sweden)

Lingegowda PB

2014-07-01

Full Text Available Pushpalatha B Lingegowda,1–3 Tan Ban Hock1,2,4,5 1Department of Infectious Diseases, Singapore General Hospital, 2DUKE-NUS Graduate Medical School, 3Yong Loo Lin School of Medicine, National University of Singapore, 4SingHealth Internal Medicine Residency Program, 5Faculty of Medicine, National University of Singapore, Singapore Abstract: Liver transplantation has emerged as a widely accepted lifesaving therapeutic option for many patients with a variety of liver diseases. Improved surgical and medical management has led to significant improvements in post-transplant survival rates with a 1 year and 5 year patient survival of 87% and 73%, respectively. A high mortality rate due to infections during the first post-transplant year persists. Invasive candidiasis is recognized as a significant problem associated with high morbidity and mortality. Recent surveillance data has helped to understand the changes in the epidemiology and the evolving trends in the use of antifungal agents for prophylaxis and treatment combined with the challenges of managing these invasive fungal infections, which has led the transplant community to explore the best management strategies. The emergence of resistant fungi and excess costs in managing these invasive fungal infections has added to the complexities of management. In this context, current perspectives in the management of Candida infections in liver transplant recipients will be reviewed. Keywords: Candida infections, management, liver transplant

"Textural analysis of multiparametric MRI detects transition zone prostate cancer".

Science.gov (United States)

Sidhu, Harbir S; Benigno, Salvatore; Ganeshan, Balaji; Dikaios, Nikos; Johnston, Edward W; Allen, Clare; Kirkham, Alex; Groves, Ashley M; Ahmed, Hashim U; Emberton, Mark; Taylor, Stuart A; Halligan, Steve; Punwani, Shonit

2017-06-01

To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had 'significant' TZ tumour. Two radiologists in consensus matched TPM to the single axial slice best depicting tumour, or largest TZ diameter for those with benign histology, to define single-slice whole TZ-regions-of-interest (ROIs). Textural-parameter differences between single-slice whole TZ-ROI containing significant tumour versus benign/insignificant tumour were analysed using Mann Whitney U test. Diagnostic accuracy was assessed by receiver operating characteristic area under curve (ROC-AUC) analysis cross-validated with leave-one-out (LOO) analysis. ADC kurtosis was significantly lower (p Textural features of the whole prostate TZ can discriminate significant prostatic cancer through reduced kurtosis of the ADC-histogram where significant tumour is included in TZ-ROI and reduced T1 entropy independent of tumour inclusion. • MR textural features of prostate transition zone may discriminate significant prostatic cancer. • Transition zone (TZ) containing significant tumour demonstrates a less peaked ADC histogram. • TZ containing significant tumour reveals higher post-contrast T1-weighted homogeneity. • The utility of MR texture analysis in prostate cancer merits further investigation.

Milla biflora Cav.-seeds, harvest and germination

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Michał W. Borys

2013-12-01

Full Text Available Milla biflora Cav. is one of six species of this genus reported to be present in Mexico. To determine the present and potential seed production of this plant, the following characteristics were studied: the number of flowers per scape, the frequencies of scape with defined number of flower per scape, the conversion of flowers into capsules, the capsule size, seed numbers, average seed size per capsule. Samplings were taken from the natural stands and evaluation of the respective attributes was done in plants growing in germplasm colIection belonging to the University UPAEP. The number of flowers ranged from 1 to 10 per scape, with 90,6% of scapes giving from 1 to 6 flowers. The capsules were formed from flowers in the following proportions: in scapes with one flower - 13,64%, in scapes with 3 flowers - 48,21%, in scapes with four or more flowers - 60%; 67,80 of capsules gave from 60 to 140 seeds; 45% of seeds had the average size from 1,81 to 2,20 mg. The mean weight of 1000 seeds was 1937.2 mg. The seeds germinated during 7 days in water, in 88 to 100%. The plant emergence from soil sown seeds ranged from 41,4 to lOO %. The seeds have not lost the germination ability after 2 years of storage at room conditions.

In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using Gastroplus™.

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Praveen, Radhakrishnan; Prasad Verma, Priya Ranjan; Venkatesan, Jayachandran; Yoon, Dong-Han; Kim, Se-Kwon; Singh, Sandeep Kumar

2017-09-01

The objective of present investigation was to develop gastro-retentive controlled release system of carvedilol using biological macromolecule, chitosan. 3 2 full factorial design was adopted for optimization of tripolyphosphate (X 1 ) and curing time (X 2 ). Bead stability in 0.1N HCl, buoyancy duration, density, drug loading, dissolution efficiency and cumulative percentage release at 8th hour were evaluated as dependent variables. The levels of X 1 and X 2 of optimized formulation having maximum desirability was found to 2.0% w/v and 62.66min, respectively. The in silico predicted responses and observed response were found to be in good agreement (percent bias error: -13.295 to +13.269). SEM images showed numerous pores in the cross sectional image that renders buoyancy. AUC 0-∞ of optimized formulation was 1.47 times higher as compared to suspension corroborating enhanced extent of absorption. T max and mean residence time were significantly higher from optimized formulation vis a vis suspension. In silico study indicated maximum regional absorption from the duodenum (94.1%) followed by jejunum (5.6%). Wagner-Nelson and Loo-Reigelman method were the preferred deconvolution approach over numerical deconvolution to establish IVIVC. In conclusion, the study showed that gastro-retentive controlled release system prepared using chitosan could be a potential drug carrier of carvedilol with improved bioavailability. Copyright © 2017 Elsevier B.V. All rights reserved.

Intramolecular energy transfer at donor-acceptor interactions in model and biological membranes

International Nuclear Information System (INIS)

Umarova, Fatima T.

2011-01-01

Intramolecular triplet-triplet energy transfer between molecules of sensibilisator and photochrome for registration of protein interactions in the membrane preparation of Na,K-ATPase was investigated. Erythrosinithiocyanate (ERITC) was used as the triplet label of sensibilisator, and 4-acetoamido-4 -isothiocyanatostilbene-2,2 disullfonic acid (SITS) was used as the photochrome label. Na,K-ATPase preparations were covalently bound with ERITC in active centre of enzyme, and SITS molecules were covalently bound by NH2-groups. In model system, in chymotrypsinogene molecule, SITS and ERITC labels were used also. The cis-trans-isomerization of SITS was initiated by triplet-triplet energy transfer from light excited ERITC molecule to photochrome. The kinetics of isomerization was recorded by the SITS fluorescence measurements. The constant of rate of triplet-triplet energy transfer from ERITC to cis-isomers of SITS in Na,K-ATPase was determined as (3-7)x10 3 M -1 s -1 , and in model system it equals 1x 10 7 M 1 s -1 . The value of energy transfer between loos molecules of erythrosine and SITS in buffer solution equaled to 7x10 7 M -1 s -1 . This drop of R m y in the membrane preparation of Na,K-ATPase at 10 4 reflected the decrease in the frequency of label collisions caused by the increase in the media viscosity and steric hindrances. (author)

Closing talk of Mr Patrick Devedjian, delegate minister of industry, following the energy debate which took place at the senate on April 27, 2004. Taken from the integral proceedings available on the Senate web site; Discours de cloture prononce par M. Patrick Devedjian, ministre delegue a l'Industrie, suite au debat sur l'energie qui s'est tenu au Senat le 27 avril 2004. A partir du compte rendu integral publie sur le site internet du Senat

Energy Technology Data Exchange (ETDEWEB)

Devedjian, P.

2004-04-01

In this talk, the French minister of industry makes a synthesis with some particular comments about the different points discussed during the energy debate organized at the French senate in April 2004: the European pressurized reactor (EPR), the management of radioactive wastes, the status of the electric and gas utilities Electricite de France (EdF) and Gaz de France (GdF) in the framework of the European deregulation of energy markets, the development of bio-fuels and renewable energy sources, the project of energy orientation law etc.. The talk includes several questions and answers with the audience. (J.S.)

Item Analysis di una prova di lettura a scelta multipla della certificazione di italiano per stranieri CILS (livello B1; sessione estiva 2012

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Paolo Torresan

2014-10-01

Full Text Available Nell’articolo presentiamo un’analisi degli item di una prova di lettura a scelta multipla di livello B1 della certificazione CILS (Università per Stranieri di Siena. L’indagine si muove da una prima ricognizione del testo su cui si basa la prova, con uno studio delle modifiche cui è andata soggetta per mano dell’item writer, per poi ragionare sull’analisi di ogni singolo item, grazie ai dati emersi dalla somministrazione della prova a 161 studenti di italiano di livello corrispondente sparsi per il pianeta. Dalla nostra ricerca si evince che si danno un item ambiguo (# 1, per via della presenza di due chiavi, e un item di difficile risoluzione, per via della mancanza di informazioni utili per desumere il significato del vocabolo cui si riferisce (# 4.In this article we present an analysis of items in a reading multiple-choice test, B1 level, of the CILS certification (Università per Stranieri di Siena. The research starts with a preliminary recognition of the text on which the test is based, with a study of the modifications it has undergone by the item writer’s hand, and proceeds to reason about the analysis of every single item, using data from the ministration of the test to 161 students of Italian in the corresponding level, from all over the planet. From our research it emerges that the test presents an ambiguous item (# 1, with two keys, and a difficult item, without enough information to make clear the meaning of the word it refers to (# 4.

Advances in forensic DNA quantification: a review.

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Lee, Steven B; McCord, Bruce; Buel, Eric

2014-11-01

This review focuses upon a critical step in forensic biology: detection and quantification of human DNA from biological samples. Determination of the quantity and quality of human DNA extracted from biological evidence is important for several reasons. Firstly, depending on the source and extraction method, the quality (purity and length), and quantity of the resultant DNA extract can vary greatly. This affects the downstream method as the quantity of input DNA and its relative length can determine which genotyping procedure to use-standard short-tandem repeat (STR) typing, mini-STR typing or mitochondrial DNA sequencing. Secondly, because it is important in forensic analysis to preserve as much of the evidence as possible for retesting, it is important to determine the total DNA amount available prior to utilizing any destructive analytical method. Lastly, results from initial quantitative and qualitative evaluations permit a more informed interpretation of downstream analytical results. Newer quantitative techniques involving real-time PCR can reveal the presence of degraded DNA and PCR inhibitors, that provide potential reasons for poor genotyping results and may indicate methods to use for downstream typing success. In general, the more information available, the easier it is to interpret and process the sample resulting in a higher likelihood of successful DNA typing. The history of the development of quantitative methods has involved two main goals-improving precision of the analysis and increasing the information content of the result. This review covers advances in forensic DNA quantification methods and recent developments in RNA quantification. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The effect of sulforaphane on the levels of serum cystatin-c in acetaminophen- induced nephrotoxicity in rats

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Eda Dokumacioglu

2016-09-01

Full Text Available Objective: The exposure of living creatures to drugs and chemicals often results in toxicity of liver and kidney. Drugs constitute an important and big part of the commu­nity and hospital-acquired kidney diseases. In this study, we investigated the effect of sulforaphane (SFN on the levels of cystatin-C and lipid peroxidation on acetamino­phen (APAP- induced nephrotoxicity in rats. Methods: Thirty-six Sprague-Dawley rats were separat­ed equally into four experimental groups: control group, SFN group, APAP group, and APAP + SFN group. In the experimental treatment groups APAP was administered oral gavage at 1 g/kg 3 h after SFN treatment in last day and, in the APAP + SFN group, SFN was administered oral gavage at a dose of 500 μg/kg exactly for three days. Rats were euthanized and sacrificed 24 h after APAP ad­ministration. Results: APAP administration showed to significant in­crease in serum BUN, creatinine, urea and LDH concen­trations as compared to the control datas indicating the induction of severe nephrotoxicity (p<0.001. SFN treat­ment significantly decreased the cystatin-C levels and lipid peroxidation compared to APAP group (p<0.05. Conclusion: The present study demonstrate that the at­tachment of SFN to the nephrotoxicity treatment protocol will be beneficial and further studies should be conducted for cystatin C which plays an important role in kidney tox­icity and disease to be routinized as a biomarker.

Les ornements liturgiques au XIXe siècle : origine, fabrication et commercialisation, l’exemple du diocèse de Moulins (Allier

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Aurore Chatard

2012-04-01

Full Text Available Depuis le concile Vatican II, la volonté de l’Église catholique de tendre vers une plus grande simplicité pour réduire la distance, tant physique que psychologique, entre ses ministres et l’ensemble des fidèles a contribué à abandonner certains fastes de la liturgie. Aujourd’hui, l’étude des ornements liturgiques rend compte de leur place au cours des rites et de l’attention portée à leur réalisation. Le XIXe siècle est souvent considéré comme l’âge d’or de leur confection. Une recherche menée dans le diocèse de Moulins a permis de mettre au jour la richesse et la diversité des collections de cette époque, ainsi que le renouvellement de la portée symbolique et politique dont ils ont fait l’objet.Since the II Vatican Council, the wish of the Catholic Church for simplification in order to reduce the distance, both physically and psychologically, between their Ministers and all the believers, contributed to abandon some complex aspects of the liturgy. Nowadays, the liturgical ornaments studying, reports their role during the rites and the particular attention paid to their realization. The XIXth century is often considered as the golden age of their confection. A research led in the diocese of Moulins, allowed to reveal the wealth and the variety of this period’s collections, as well as the renewal of their symbolic and political mean.

Dostępność serwisów internetowych na przykładzie pakietu startowego JBiblioteka

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Dominik Mirosław Piotrowski

2016-12-01

Full Text Available JBiblioteka to innowacyjny pakiet startowy (oparty na open source CMS Joomla! dla bibliotek publicznych, kładący nacisk na dostępność stron internetowych (accessibility. Biblioteki za jego pomocą mogą wdrożyć gotowy portal internetowy, który z założenia spełnia wymagania standardu WCAG 2.0 (Web Content Accessibility Guidelines oraz użyteczności (usability serwisów www. Jest to niezwykle ważne ze względu na Rozporządzenie Rady Ministrów z dnia 12 kwietnia 2012 r. w sprawie Krajowych Ram Interoperacyjności, minimalnych wymagań dla rejestrów publicznych i wymiany informacji w postaci elektronicznej oraz minimalnych wymagań dla systemów teleinformatycznych (Dz. U. 2012, pozycja 526. Rozporządzenie to zobowiązuje podmioty realizujące zadania publiczne do dostosowania serwisów www do standardu WCAG 2.0, uznanego w większości krajów Europy. W artykule zaprezentowano wyniki analizy eksperckiej dotyczącej przeglądu funkcjonalności pakietu JBiblioteka oraz analizy jego dostępności. Głównym celem niniejszego tekstu jest przedstawienie nowych rozwiązań w zakresie dostosowywania serwisów internetowych do potrzeb osób z różnego typu niepełnosprawnościami oraz zaznajomienie środowiska bibliotekarskiego z innowacyjnymi rozwiązaniami w zakresie podnoszenia jakości bibliotecznych serwisów internetowych.

Chemical composition of the essential oils of Citrus sinensis cv. valencia and a quantitative structure-retention relationship study for the prediction of retention indices by multiple linear regression

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Larijani Kambiz

2011-01-01

Full Text Available The chemical composition of the volatile fraction obtained by head-space solid phase microextraction (HS-SPME, single drop microextraction (SDME and the essential oil obtained by cold-press from the peels of C. sinensis cv. valencia were analyzed employing gas chromatography-flame ionization detector (GC-FID and gas chromatography-mass spectrometry (GC-MS. The main components were limonene (61.34 %, 68.27 %, 90.50 %, myrcene (17.55 %, 12.35 %, 2.50 %, sabinene (6.50 %, 7.62 %, 0.5 % and α-pinene (0 %, 6.65 %, 1.4 % respectively obtained by HS-SPME, SDME and cold-press. Then a quantitative structure-retention relationship (QSRR study for the prediction of retention indices (RI of the compounds was developed by application of structural descriptors and the multiple linear regression (MLR method. Principal components analysis was used to select the training set. A simple model with low standard errors and high correlation coefficients was obtained. The results illustrated that linear techniques such as MLR combined with a successful variable selection procedure are capable of generating an efficient QSRR model for prediction of the retention indices of different compounds. This model, with high statistical significance (R2 train = 0.983, R2 test = 0.970, Q2 LOO = 0.962, Q2 LGO = 0.936, REP(% = 3.00, could be used adequately for the prediction and description of the retention indices of the volatile compounds.

Bayesian Dimensionality Assessment for the Multidimensional Nominal Response Model

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Javier Revuelta

2017-06-01

Full Text Available This article introduces Bayesian estimation and evaluation procedures for the multidimensional nominal response model. The utility of this model is to perform a nominal factor analysis of items that consist of a finite number of unordered response categories. The key aspect of the model, in comparison with traditional factorial model, is that there is a slope for each response category on the latent dimensions, instead of having slopes associated to the items. The extended parameterization of the multidimensional nominal response model requires large samples for estimation. When sample size is of a moderate or small size, some of these parameters may be weakly empirically identifiable and the estimation algorithm may run into difficulties. We propose a Bayesian MCMC inferential algorithm to estimate the parameters and the number of dimensions underlying the multidimensional nominal response model. Two Bayesian approaches to model evaluation were compared: discrepancy statistics (DIC, WAICC, and LOO that provide an indication of the relative merit of different models, and the standardized generalized discrepancy measure that requires resampling data and is computationally more involved. A simulation study was conducted to compare these two approaches, and the results show that the standardized generalized discrepancy measure can be used to reliably estimate the dimensionality of the model whereas the discrepancy statistics are questionable. The paper also includes an example with real data in the context of learning styles, in which the model is used to conduct an exploratory factor analysis of nominal data.

Detection of Vero Cells Infected with Herpes Simplex Types 1 and 2 and Varicella Zoster Viruses Using Raman Spectroscopy and Advanced Statistical Methods.

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Huleihel, Mahmoud; Shufan, Elad; Zeiri, Leila; Salman, Ahmad

2016-01-01

Of the eight members of the herpes family of viruses, HSV1, HSV2, and varicella zoster are the most common and are mainly involved in cutaneous disorders. These viruses usually are not life-threatening, but in some cases they might cause serious infections to the eyes and the brain that can lead to blindness and possibly death. An effective drug (acyclovir and its derivatives) is available against these viruses. Therefore, early detection and identification of these viral infections is highly important for an effective treatment. Raman spectroscopy, which has been widely used in the past years in medicine and biology, was used as a powerful spectroscopic tool for the detection and identification of these viral infections in cell culture, due to its sensitivity, rapidity and reliability. Our results showed that it was possible to differentiate, with a 97% identification success rate, the uninfected Vero cells that served as a control, from the Vero cells that were infected with HSV-1, HSV-2, and VZV. For that, linear discriminant analysis (LDA) was performed on the Raman spectra after principal component analysis (PCA) with a leave one out (LOO) approach. Raman spectroscopy in tandem with PCA and LDA enable to differentiate among the different herpes viral infections of Vero cells in time span of few minutes with high accuracy rate. Understanding cell molecular changes due to herpes viral infections using Raman spectroscopy may help in early detection and effective treatment.

Detection of Vero Cells Infected with Herpes Simplex Types 1 and 2 and Varicella Zoster Viruses Using Raman Spectroscopy and Advanced Statistical Methods.

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Mahmoud Huleihel

Full Text Available Of the eight members of the herpes family of viruses, HSV1, HSV2, and varicella zoster are the most common and are mainly involved in cutaneous disorders. These viruses usually are not life-threatening, but in some cases they might cause serious infections to the eyes and the brain that can lead to blindness and possibly death. An effective drug (acyclovir and its derivatives is available against these viruses. Therefore, early detection and identification of these viral infections is highly important for an effective treatment. Raman spectroscopy, which has been widely used in the past years in medicine and biology, was used as a powerful spectroscopic tool for the detection and identification of these viral infections in cell culture, due to its sensitivity, rapidity and reliability. Our results showed that it was possible to differentiate, with a 97% identification success rate, the uninfected Vero cells that served as a control, from the Vero cells that were infected with HSV-1, HSV-2, and VZV. For that, linear discriminant analysis (LDA was performed on the Raman spectra after principal component analysis (PCA with a leave one out (LOO approach. Raman spectroscopy in tandem with PCA and LDA enable to differentiate among the different herpes viral infections of Vero cells in time span of few minutes with high accuracy rate. Understanding cell molecular changes due to herpes viral infections using Raman spectroscopy may help in early detection and effective treatment.

Feasibility of diffuse reflectance infrared Fourier spectroscopy (DRIFTS) to quantify iron-cyanide (Fe-CN) complexes in soil

Science.gov (United States)

Sut-Lohmann, Magdalena; Raab, Thomas

2017-04-01

Contaminated sites create a significant risk to human health, by poisoning drinking water, soil, air and as a consequence food. Continuous release of persistent iron-cyanide (Fe-CN) complexes from various industrial sources poses a high hazard to the environment and indicates the necessity to analyze considerable amount of samples. At the present time quantitative determination of Fe-CN concentration in soil usually requires a time consuming two step process: digestion of the sample (e.g., micro distillation system) and its analytical detection performed, e.g., by automated spectrophotometrical flow injection analysis (FIA). In order to determine the feasibility of diffuse reflectance infrared Fourier spectroscopy (DRIFTS) to quantify the Fe-CN complexes in soil matrix, 42 soil samples were collected (8 to 12.520 mg kg-1CN) indicating single symmetrical CN band in the range 2092 - 2084 cm-1. Partial least squares (PLS) calibration-validation model revealed IR response to CNtot exceeding 1268 mg kg-1 (limit of detection, LOD). Subsequently, leave-one-out cross-validation (LOO-CV) was performed on soil samples containing low CNtot (900 mg kg-1 resulted in LOD equal to 3494 mg kg-1. Our results indicate that spectroscopic data in combination with PLS statistics can efficiently be used to predict Fe-CN concentrations in soil. We conclude that the protocol applied in this study can strongly reduce the time and costs essential for the spatial and vertical screening of the site affected by complexed Fe-CN.

Prediction of supercooled liquid vapor pressures and n-octanol/air partition coefficients for polybrominated diphenyl ethers by means of molecular descriptors from DFT method

International Nuclear Information System (INIS)

Wang Zunyao; Zeng Xiaolan; Zhai Zhicai

2008-01-01

The molecular geometries of 209 polybrominated diphenyl ethers (PBDEs) were optimized at the B3LYP/6-31G* level with Gaussian 98 program. The calculated structural parameters were taken as theoretical descriptors to establish two novel QSPR models for predicting supercooled liquid vapor pressures (P L ) and octanol/air partition coefficients (K OA ) of PBDEs based on the theoretical linear solvation energy relationship (TLSER) model, respectively. The two models achieved in this work both contain three variables: most negative atomic partial charge in molecule (q - ), dipole moment of the molecules (μ) and mean molecular polarizability (α), of which R 2 values are both as high as 0.997, their root-mean-square errors in modeling (RSMEE) are 0.069 and 0.062 respectively. In addition, the F-value of two models are both evidently larger than critical values F 0.05 and the variation inflation factors (VIF) of variables herein are all less than 5.0, suggesting obvious statistic significance of the P L and K OA predicting models. The results of Leave-One-Out (LOO) cross-validation for training set and validation with external test set both show that the two models obtained exhibited optimum stability and good predictive power. We suggest that the QSPRs derived here can be used to predict accurately P L and K OA for non-tested PBDE congeners from Mono-BDEs to Hepta-BDEs and from Mono-BDEs to Hexa-BDEs, respectively

Spatial downscaling algorithm of TRMM precipitation based on multiple high-resolution satellite data for Inner Mongolia, China

Science.gov (United States)

Duan, Limin; Fan, Keke; Li, Wei; Liu, Tingxi

2017-12-01

Daily precipitation data from 42 stations in Inner Mongolia, China for the 10 years period from 1 January 2001 to 31 December 2010 was utilized along with downscaled data from the Tropical Rainfall Measuring Mission (TRMM) with a spatial resolution of 0.25° × 0.25° for the same period based on the statistical relationships between the normalized difference vegetation index (NDVI), meteorological variables, and digital elevation models (https://en.wikipedia.org/wiki/Digital_elevation_model) (DEM) using the leave-one-out (LOO) cross validation method and multivariate step regression. The results indicate that (1) TRMM data can indeed be used to estimate annual precipitation in Inner Mongolia and there is a linear relationship between annual TRMM and observed precipitation; (2) there is a significant relationship between TRMM-based precipitation and predicted precipitation, with a spatial resolution of 0.50° × 0.50°; (3) NDVI and temperature are important factors influencing the downscaling of TRMM precipitation data for DEM and the slope is not the most significant factor affecting the downscaled TRMM data; and (4) the downscaled TRMM data reflects spatial patterns in annual precipitation reasonably well, showing less precipitation falling in west Inner Mongolia and more in the south and southeast. The new approach proposed here provides a useful alternative for evaluating spatial patterns in precipitation and can thus be applied to generate a more accurate precipitation dataset to support both irrigation management and the conservation of this fragile grassland ecosystem.

Cheminformatics Modeling of Amine Solutions for Assessing their CO2 Absorption Properties.

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Kuenemann, Melaine A; Fourches, Denis

2017-07-01

As stricter regulations on CO 2 emissions are adopted worldwide, identifying efficient chemical processes to capture and recycle CO 2 is of critical importance for industry. The most common process known as amine scrubbing suffers from the lack of available amine solutions capable of capturing CO 2 efficiently. Tertiary amines characterized by low heats of reaction are considered good candidates but their absorption properties can significantly differ from one analogue to another despite high structural similarity. Herein, after collecting and curating experimental data from the literature, we have built a modeling set of 41 amine structures with their absorption properties. Then we analyzed their chemical composition using molecular descriptors and non-supervised clustering. Furthermore, we developed a series of quantitative structure-property relationships (QSPR) to assess amines' CO 2 absorption properties from their structural characteristics. These models afforded reasonable prediction performances (e. g., Q 2 LOO =0.63 for CO 2 absorption amount) even though they are solely based on 2D chemical descriptors and individual machine learning techniques (random forest and neural network). Overall, we believe the chemical analysis and the series of QSPR models presented in this proof-of-concept study represent new knowledge and innovative tools that could be very useful for screening and prioritizing hypothetical amines to be synthesized and tested experimentally for their CO 2 absorption properties. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Impact of faculty development programs for positive behavioural changes among teachers: a case study

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Shuh Shing Lee

2018-03-01

Full Text Available Purpose Faculty development (FD is essential to prepare faculty members to become effective teachers to meet the challenges in medical education. Despite the growth of FD programmes, most evaluations were often conducted using short questionnaires to assess participants’ satisfaction immediately after they attended a programme. Consequently, there were calls for more rigorous evaluations based on observed changes in participants’ behaviours. Hence, this study aims to explore how the FD workshops run by the Centre for Medical Education, Yong Loo Lin School of Medicine, National University of Singapore have impacted behavioural changes in the educators. Methods We followed up with the educators at least half a year after they have attended the workshops. With limited literature as reference, we initiated a small-scale case-study research design involving semi-structured interviews with six educators which was triangulated with three focus group discussions with their students. This allowed us to explore behavioural changes among the educators as well as evaluate the feasibility of this research methodology. Results We identified three emerging categories among the educators: ignorance to awareness, from intuition to confirmation and expansion, and from individualism to community of practice. Conclusion Although FD have placed much emphasis on teaching and learning approaches, we found that the teacher-student interaction or human character components (passionate, willing to sacrifice, are open to feedback in becoming a good educator are lacking in our FD workshops.

Characteristics, Composition and Oxidative Stability of Lannea microcarpa Seed and Seed Oil

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Patrice Bazongo

2014-02-01

Full Text Available The proximate composition of seeds and main physicochemical properties and thermal stability of oil extracted from Lannea microcarpa seeds were evaluated. The percentage composition of the seeds was: ash (3.11%, crude oil (64.90%, protein (21.14%, total carbohydrate (10.85% and moisture (3.24%. Physicochemical properties of the oil were: refractive index, 1.473; melting point, 22.60°C; saponification value, 194.23 mg of KOH/g of oil; iodine value, 61.33 g of I2/100 g of oil; acid value, 1.21 mg of KOH/g of oil; peroxide value, 1.48 meq of O2/kg of oil and oxidative stability index, 43.20 h. Oleic (43.45%, palmitic (34.45%, linoleic (11.20% and stearic (8.35% acids were the most dominant fatty acids. Triacylglycerols with equivalent carbon number (ECN 48 and ECN 46 were dominant (46.96% and 37.31%, respectively. The major triacylglycerol constituents were palmitoyl diolein (POO (21.23%, followed by dipalmitoyl olein (POP (16.47%, palmitoyl linoleyl olein (PLO (12.03%, dipalmitoyl linolein (PLP (10.85% and dioleoyl linolein (LOO (9.30%. The total polyphenol and tocopherol contents were 1.39 mg GAE g−1 DW and 578.56 ppm, respectively. γ-Tocopherol was the major tocopherol (437.23 ppm. These analytical results indicated that the L. microcarpa seed oil could be used as a frying oil and in the cosmetic industry.

Involvement of active oxygen in lipid peroxide radical reaction of epidermal homogenate following ultraviolet light exposure

International Nuclear Information System (INIS)

Nishi, J.; Ogura, R.; Sugiyama, M.; Hidaka, T.; Kohno, M.

1991-01-01

To elucidate the radical mechanism of lipid peroxidation induced by ultraviolet light (UV) irradiation, an electron spin resonance (ESR) study was made on epidermal homogenate prepared from albino rat skin. The exposure of the homogenate to UV light resulted in an increase in lipid peroxide content, which was proportional to the time of UV exposure. Using ESR spin trapping (dimethyl-1-pyrroline-N-oxide, DMPO), the DMPO spin adduct spectrum of lipid radicals (L.) was measured following UV exposure (DMPO-L.:aN = 15.5 G, aH = 22.7 G), as was the spectrum of DMPO-hydroxyl radical (DMPO-OH, aN = aH = 15.5 G). In the presence of superoxide dismutase, the DMPO spin adduct spectrum of lipid radicals was found to be reduced remarkably. Therefore, it was shown that the generation of the lipid radicals partially involves superoxide anion radicals, in addition to hydroxyl radicals. In the ESR free-radical experiment, an ESR signal appeared at g = 2.0064 when the ESR tube filled with homogenate was exposed to UV light at -150 degrees C. The temperature-dependent change in the ESR free radical signal of homogenate exposed to UV light was observed at temperatures varying from -150 degrees C to room temperature. By using degassed samples, it was confirmed that oxygen is involved in the formation of the lipid peroxide radicals (LOO.) from the lipid radicals (L.)

Closure of the first strategic meeting on energy security: 'Europe running out of energy?' at the economic and social council. Talk of Francois Loos, delegate minister of industry

International Nuclear Information System (INIS)

2005-01-01

In this talk, the French minister briefly recalls the present day world energy and environmental situation and the urgent need of new clean energy sources. Then, he presents some strong actions already launched by the European Union to reduce its energy dependence (Green Books on the security of energy supplies and on the energy efficiency) and he introduces the French program law and its ambitious goals: abatement of the final energy intensity thanks to the development of alternate fuels in transports and to the implementation of energy saving certificates, increase of the share of renewable energy sources in the French energy mix and keeping up of the nuclear option, replacement of old fossil-fuel power plants, reinforcement of power gas interconnections between France and neighbour countries, and significant increase of the R and D effort in new energy technologies, CO 2 sequestration and nuclear fusion. (J.S.)

固定资产会计准则与税法差异研究%Study on the Difference of Fixed Assets between Accounting Standards and Taxation

Institute of Scientific and Technical Information of China (English)

曹越; 刘金; 罗腾

2011-01-01

The difference of develop goals and principles between accounting standards and taxation results in many differences when companies process the accounting transactions and tax treatment on the fixed asset. By comparing, we know that the differences are mainly in these aspects： the recognition, initial measurement, subsequent measurement and disposal etc. It affects the calculation about taxable income and tax payable, and increases companies＇ financial workload and the difficnlty of monitoring of tax department. We suggest that based on the respect for difference, strengthening the co- ordination of accounting standards and taxation, and improving the effectiveness and efficiency of accounting and tax ad- ministration are the top priority.%企业会计准则与税法制定目标与原则的不同导致固定资产会计与税务处理存在诸多差异。这种差异主要表现在固定资产确认、初始计量、后续计量以及处置等方面，并影响企业应纳税所得额和应交所得税的计算，增加企业的财务工作量和税务部门的税务监管难度。建议在尊重差异的基础上，加强会计准则与税法的协调，提高会计处理与税收征管工作的效果和效率。

Politics of local militia lords in the southwest China in the period of Nanjing Government： a case in Chongqing, Sichuan%南京政府时期西南地区的团阀政治——以四川重庆地区团阀为个案的考察

Institute of Scientific and Technical Information of China (English)

王明前

2012-01-01

团阀政治是在四川防区制时代社会动荡不安的时代背景和社会环境下,一部分地方名流借地方自治办理团防武装,和中央集权官僚行政衰微甚至笼络地方名流之机,垄断地方行政事务而形成的特殊历史现象。在铲除团阀后,刘湘当局通过强化县级行政对地方团防的督导权,把团防改造为平时负责社会治安、战时承担战争勤务职能的社会保障工具。%The politics of local militia lords was a special historical phenomenon formed in the unsettled social condition in the Sichuan defense-area-system times. Some prominent persons, taking advantage of the weakness of the centralized bureaucratic ad- ministration of the central government, organized some armed forces and monopolized the local administrative affairs. The clash a- mong army groups was a variant of the tangled warfare among warlords. After eradicating the militia lords, Liu Xiang＇s government, by strengthening the supervising right of county-level administration over the local militia defense, reformed the militia defense to be the social security tool, which was responsible for social security when in peace and shouldered the service function when at war.

Les procès contre le sanctuaire Yasukuni The trials of WW2 veterans’ families against the Yasukuni shrine

Directory of Open Access Journals (Sweden)

Nobumasa Tanaka

2010-07-01

Full Text Available Le sanctuaire Yasukuni a été fondé à Tôkyô en 1869 par l’empereur Meiji pour célébrer la mémoire des guerriers japonais tombés au combat pour l’empereur et la patrie. Etablissement religieux chargé d’honorer les hauts faits de ces « âmes héroïques », il fut longtemps le symbole du militarisme japonais. Or, parmi les familles qui ont perdu l’un des leurs au cours de la guerre d’agression menée par le Japon en Asie, certaines ont engagé des poursuites contre l’administration du Yasukuni, afin d’obtenir que les noms de leurs proches soient radiés des listes du sanctuaire. Cet article retrace l’historique des procès engagés par ces familles, en examinant au passage les plaintes déposées contre le caractère anticonstitutionnel des visites répétées du Premier ministre Koizumi au Yasukuni.The Yasukuni shrine was founded in Tokyo in 1868 by the Emperor Meiji to celebrate the memory of Japanese warriors fallen during battles for the Emperor and the country. As religious institution devoted to honor these “brave souls”, it became the symbol of Japanese militarism. However, among the families who lost relatives during the war, some have sued the administration of Yasukuni to get the names of their relatives deleted from the lists of the shrine. This article describes the genesis of those trials and exams also the anti-constitutional nature of the repeated visits of Prime Minister Koizumi to Yasukuni.

Le parcours d’un juste: mémoires politiques, mémoires militantes

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Alexandra Borsari

2012-07-01

Full Text Available Avocat engagé, Robert Badinter s'est retrouvé en situation de mettre en pratique ses idéaux. Son dernier livre, Les épines et les roses, publié chez Fayard (Paris, 2011 est le récit de son parcours de ministre de la Justice. Cet ouvrage soulève ainsi des questions sur les rapports entre mémoires rédigées et image de soi, mais aussi entre la mémoire du sujet et la mémoire collective à laquelle il participe. En racontant sa version du passé, l'auteur entend influencer la lecture de celui-ci et contrôler, en partie, le souvenir qui en sera gardé dans l'opinion. Car, bien qu'il se présente tout au long de l'ouvrage comme un homme ordinaire, arrivé de manière inattendue au pouvoir, Robert Badinter omet de rappeler que tout son parcours postérieur à cette expérience de ministre s'est déroulée à des niveaux de responsabilité en lien étroit avec le pouvoir politique. Après cet accès momentané au pouvoir exécutif, Robert Badinter a ainsi été président du Conseil constitutionnel, fonction à forte dimension politique, avant d'accéder à des fonctions prestigieuses au niveau international. Enfin, son parcours politique s'est poursuivi par son élection au Sénat et donc par une participation directe à l'exercice du pouvoir législatif. Bien sûr, les responsabilités ne sont pas les mêmes, et pour quelqu'un qui s'est souvent refusé à parler de lui, se mettre en scène en tant que garde des Sceaux revêt une signification particulière. Il s'agit ainsi de rendre pérenne le souvenir d'un combat et d'une action dont les résultats les plus forts – abolition de la peine de mort et réforme du code pénal – continuent de façonner, à leur manière, la société française. Mais au-delà du bilan, ce retour sur le passé est également l'occasion de s'ériger en juge du temps présent. Le combat n'est pas terminé et cet ouvrage se veut aussi une oeuvre militante. En analysant cette volonté de se présenter en

La obra literaria de Hildegard de Bingen (1098 - 1179

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María Eugenia Góngora

2016-03-01

Full Text Available La obra lírica de Hildegard de Bingen (1098-1179 nos plantea interesantes problemas para una lectura actual. Se trata de composiciones destinadas a la liturgia de su monasterio de Rupertsberg y, si buscamos en ellas la presencia de una voz lírica propia, percibimos en primer lugar la ausencia de un "yo" gramatical y la repetida enunciación de realidades sobrenaturales y espirituales que se confirman en esta poesía como verdades objetivas. Por otra parte, la presencia frecuente de un "nosotros" gramatical y el contexto en el que esta obra fue creada, cantada y difundida, nos permite creer que la "voz propia" es aquí fundamentalmente una voz comunitaria y monástica, la voz de un "nosotros" en la comunidad modelo fundada por Hildegard. The lyrical work of Hildegard van Bingen raises interesting problems for a contemporary reading. It in eludes compositions meant for the liturgy of her monastery at Rupertsberg, and, should we loo k in them for the presence of a lyrical voice, we would first re alise the absence of a grammatical 'self', together with the repeated enunciation of supematural and spiritual realities, which confirm themselves in the poetry as objective truths. On the other hand, the frequent references toa grammatical 'we ', as well as the context within which this work was created, sung and divulged, permit the belie.f that the 'personal voice ', is, fundamentally, a monastic communitarian voice, the voice of a plurality in the model community founded by Hildegard.

Discovery of DPP IV inhibitors by pharmacophore modeling and QSAR analysis followed by in silico screening.

Science.gov (United States)

Al-Masri, Ihab M; Mohammad, Mohammad K; Taha, Mutasem O

2008-11-01

Dipeptidyl peptidase IV (DPP IV) deactivates the natural hypoglycemic incretin hormones. Inhibition of this enzyme should restore glucose homeostasis in diabetic patients making it an attractive target for the development of new antidiabetic drugs. With this in mind, the pharmacophoric space of DPP IV was explored using a set of 358 known inhibitors. Thereafter, genetic algorithm and multiple linear regression analysis were employed to select an optimal combination of pharmacophoric models and physicochemical descriptors that yield selfconsistent and predictive quantitative structure-activity relationships (QSAR) (r(2) (287)=0.74, F-statistic=44.5, r(2) (BS)=0.74, r(2) (LOO)=0.69, r(2) (PRESS) against 71 external testing inhibitors=0.51). Two orthogonal pharmacophores (of cross-correlation r(2)=0.23) emerged in the QSAR equation suggesting the existence of at least two distinct binding modes accessible to ligands within the DPP IV binding pocket. Docking experiments supported the binding modes suggested by QSAR/pharmacophore analyses. The validity of the QSAR equation and the associated pharmacophore models were established by the identification of new low-micromolar anti-DPP IV leads retrieved by in silico screening. One of our interesting potent anti-DPP IV hits is the fluoroquinolone gemifloxacin (IC(50)=1.12 muM). The fact that gemifloxacin was recently reported to potently inhibit the prodiabetic target glycogen synthase kinase 3beta (GSK-3beta) suggests that gemifloxacin is an excellent lead for the development of novel dual antidiabetic inhibitors against DPP IV and GSK-3beta.

Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure–Activity Relationship (HQSAR Modeling of Amino–Imino Tautomers

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Marcelle L. F. Bispo

2017-06-01

Full Text Available In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, and C of 7-chloro-4-aminoquinolines, which were evaluated in vitro against Mycobacterium tuberculosis (MTB. Now, we report the anti-MTB and cytotoxicity evaluations of a new series, D (D01–D21. Considering the active compounds of series A (A01–A13, B (B01–B13, C (C01–C07, and D (D01–D09, we compose a data set of 42 compounds and carried out hologram quantitative structure–activity relationship (HQSAR analysis. The amino–imino tautomerism of the 4-aminoquinoline moiety was considered using both amino (I and imino (II forms as independent datasets. The best HQSAR model from each dataset was internally validated and both models showed significant statistical indexes. Tautomer I model: leave-one-out (LOO cross-validated correlation coefficient (q2 = 0.80, squared correlation coefficient (r2 = 0.97, standard error (SE = 0.12, cross-validated standard error (SEcv = 0.32. Tautomer II model: q2 = 0.77, r2 = 0.98, SE = 0.10, SEcv = 0.35. Both models were externally validated by predicting the activity values of the corresponding test set, and the tautomer II model, which showed the best external prediction performance, was used to predict the biological activity responses of the compounds that were not evaluated in the anti-MTB trials due to poor solubility, pointing out D21 for further solubility studies to attempt to determine its actual biological activity.

Molecular modeling-driven approach for identification of Janus kinase 1 inhibitors through 3D-QSAR, docking and molecular dynamics simulations.

Science.gov (United States)

Itteboina, Ramesh; Ballu, Srilata; Sivan, Sree Kanth; Manga, Vijjulatha

2017-10-01

Janus kinase 1 (JAK 1) belongs to the JAK family of intracellular nonreceptor tyrosine kinase. JAK-signal transducer and activator of transcription (JAK-STAT) pathway mediate signaling by cytokines, which control survival, proliferation and differentiation of a variety of cells. Three-dimensional quantitative structure activity relationship (3 D-QSAR), molecular docking and molecular dynamics (MD) methods was carried out on a dataset of Janus kinase 1(JAK 1) inhibitors. Ligands were constructed and docked into the active site of protein using GLIDE 5.6. Best docked poses were selected after analysis for further 3 D-QSAR analysis using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methodology. Employing 60 molecules in the training set, 3 D-QSAR models were generate that showed good statistical reliability, which is clearly observed in terms of r 2 ncv and q 2 loo values. The predictive ability of these models was determined using a test set of 25 molecules that gave acceptable predictive correlation (r 2 Pred ) values. The key amino acid residues were identified by means of molecular docking, and the stability and rationality of the derived molecular conformations were also validated by MD simulation. The good consonance between the docking results and CoMFA/CoMSIA contour maps provides helpful clues about the reasonable modification of molecules in order to design more efficient JAK 1 inhibitors. The developed models are expected to provide some directives for further synthesis of highly effective JAK 1 inhibitors.

RAMAN SPECTROSCOPIC STUDY ON PREDICTION OF TREATMENT RESPONSE IN CERVICAL CANCERS

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S. RUBINA

2013-04-01

Full Text Available Concurrent chemoradiotherapy (CCRT is the choice of treatment for locally advanced cervical cancers; however, tumors exhibit diverse response to treatment. Early prediction of tumor response leads to individualizing treatment regimen. Response evaluation criteria in solid tumors (RECIST, the current modality of tumor response assessment, is often subjective and carried out at the first visit after treatment, which is about four months. Hence, there is a need for better predictive tool for radioresponse. Optical spectroscopic techniques, sensitive to molecular alteration, are being pursued as potential diagnostic tools. Present pilot study aims to explore the fiber-optic-based Raman spectroscopy approach in prediction of tumor response to CCRT, before taking up extensive in vivo studies. Ex vivo Raman spectra were acquired from biopsies collected from 11 normal (148 spectra, 16 tumor (201 spectra and 13 complete response (151 CR spectra, one partial response (8 PR spectra and one nonresponder (8 NR spectra subjects. Data was analyzed using principal component linear discriminant analysis (PC-LDA followed by leave-one-out cross-validation (LOO-CV. Findings suggest that normal tissues can be efficiently classified from both pre- and post-treated tumor biopsies, while there is an overlap between pre- and post-CCRT tumor tissues. Spectra of CR, PR and NR tissues were subjected to principal component analysis (PCA and a tendency of classification was observed, corroborating previous studies. Thus, this study further supports the feasibility of Raman spectroscopy in prediction of tumor radioresponse and prospective noninvasive in vivo applications.

Ecto- and endoparasites in remaining population of wild rabbit Oryctolagus cuniculus (L., 1758 in east Bohemia

Directory of Open Access Journals (Sweden)

Vladimír Bádr

2005-01-01

Full Text Available An investigation of ecto- and endoparasites of wild rabbit Oryctolagus cuniculus (L., 1758 was made during February and March 2004. Together five species of ectoparasites and seven species of endopara- sites was found in five specimens of host. Ectoparasites: acarids Leporacarus gibbus (Pagenstecher, 1862, Psoroptes cuniculi (Delafond, 1859, and Cheyletiella parasitivorax (Mégnin, 1878, flea Spilopsyllus cuniculi (Dale, 1878, and louse Haemodipsus ventricosus (Denny, 1842. Except of petechial haemorrhagies inside both earlobes of one rabbit neither hyperkeratosis nor scale with any degrees of hairlessness were detected. Higher incidence of flea Spilopsyllus cuniculi could be important for spreading of myxomatosis. In one rabbit abnormal damage of incisivi was found, which caused the highest documented incidence of acarids Cheyletiella parasitivorax (485 ex., fleas Spilopsyllus cuniculi (65 ex., and especially enormous amount of louse Haemodipsus ventricosus (1840 ex. This finding establish close relation between prevalence and counts of ectoparasites with health of host, because popu- lation of ectoparasites from different taxonomic groups are principally affected by effective hostęs cleanup. Handicapped hosts are not able to make clarify as effective as the healthy ones. Endoparasites: tapeworm Taenia pisiformis (Bloch, 1780 – larvae, nematods Passalurus ambiguus (Rudolphi, 1819 Rudolphi, 1845; Graphidium strigosum (Dujardin, 1845 Railliet and Henry, 1909, Trichostrongylus retortaeformis (Zeder, 1800 Loos, 1905 and protozoa Eimeria piriformis Kotlan & Pospesch, 1934; E. media Kessel, 1929, and E. perforans (Leuckart, 1879 Sluiter & Swellengrebel, 1912. All endoparasites were found in very low or middle intensity, which does not seem to be main cause of decreasing number of wild rabbits in monitored areas.

The effect of intravitreal injections on dry eye, and proposed management strategies

Directory of Open Access Journals (Sweden)

Laude A

2017-08-01

Full Text Available Augustinus Laude,1–3 Jimmy WK Lim,1,2 Vishwanath Srinagesh,4 Louis Tong2,5–7 1National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 2Singapore Eye Research Institute, 3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 4Krieger Eye Institute, Baltimore, MD, USA; 5Singapore National Eye Centre, 6Duke NUS Medical School, 7Yong Loo Lin School of Medicine, National University of Singapore, Singapore Abstract: Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF agents has become a commonly used treatment method for a number of ophthalmic conditions, including age-related macular degeneration. Although anti-VEGF therapy has shown promising results for many patients, there are several aspects of its application that have not been thoroughly investigated. One of these is the development and/or escalation of concurrent dry eye syndrome. Many patients undergoing treatment are already predisposed to dry eye disease due to their age and overall ocular health. As dry eye can have a substantial impact on quality of life, it has become increasingly apparent that the clinical signs and symptoms should be closely monitored and aggressively managed. This will allow for the optimization of patient comfort and visual potential. Here, we discuss the reasons why dry eye may develop during the course of repeated ocular anti-VEGF therapy, highlighting the key concerns about current practices and proposing possible solutions to improve the outcome for the patients. Keywords: age-related macular degeneration, povidone–iodine, toxicity, ocular health, chronic ophthalmic treatment

Selected Lectures of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018

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--- Various Authors

2018-03-01

Full Text Available Selected Lectures of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018 CONGRESS PRESIDENT Paolo Biban  Guest Editor: Paolo BibanLECT 1. RESUSCITATION OF EXTREMELY PREMATURE INFANTS: HOW TO IMPROVE EVEN FURTHER • J.M. PerlmanLECT 2. MAINTAINING NORMAL TEMPERATURE IN THE NEWLY BORN: NOT A TRIVIAL GAME • J. WyllieLECT 3. PRESENT AND FUTURE OF SURFACTANT AD­MINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS • A. KribsLECT 4. CONTINUOUS POSITIVE AIRWAY PRES­SURE (CPAP, SURFACTANT, OR BOTH? A DILEMMA STILL WAITING TO BE SOLVED • D. De LucaLECT 5. NON-INVASIVE RESPIRATORY SUPPORT AND RESPIRATORY DISTRESS SYNDROME (RDS: IS NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE (nCPAP ALWAYS ENOUGH? • G. Lista, I. BresestiLECT 6. NEURALLY ADJUSTED VENTILATORY ASSIST (NAVA IN THE NEWBORN: A NEW STANDARD OF CARE? • H. SteinLECT 7. HIGH-FREQUENCY, MULTI-FREQUENCY OSCIL­LA­TION, JET VENTILATION: WHERE ARE WE? • J.J. PillowLECT 8. SURVIVAL AND NEURODEVELOPMENTAL OUT­COME IN PERIVIABLE INFANTS • N. YoungeLECT 9. PATHOPHYSIOLOGY AND TREATMENT OF SEPTIC SHOCK IN NEONATES • H.R. WongLECT 10. CLINICAL METABOLOMICS IN NEONATAL SEPSIS • V. FanosLECT 11. OPTIMIZING EARLY NUTRITION SUPPORT IN VERY LOW BIRTH WEIGHT (VLBW INFANTS • T. SenterreLECT 12. LONG-TERM ADVERSE EFFECTS OF EARLY GROWTH ACCELERATION OR CATCH-UP GROWTH • A. SinghalLECT 13. ROLE OF NEAR INFRARED SPECTROSCOPY DURING NEONATAL TRANSITION • B. UrlesbergerLECT 14. HEART RATE CHARACTERISTICS AS PHYSIO­MARKERS FOR DETECTION OF SEPSIS AND OTHER DISEASES • K.D. FairchildLECT 15. ENHANCED CARDIORESPIRATORY MONI­TORING OF THE PRETERM INFANT DURING STABILIZA­TION IN THE DELIVERY ROOM • E. Dempsey

An adolescent ward; 'in name only?'.

Science.gov (United States)

Hutton, Alison

2008-12-01

The aim of the study was to explore how an adolescent ward was used by the two main users, nurses and adolescents, on a purpose-built adolescent ward. In Australia, caring for the adolescent is part of paediatric nursing and many Australian hospitals boast of 'adolescent-only facilities'. These wards are established on the premise that adolescent patients are a 'special' group deserving their own ward space. With the development of adolescent wards, set ideals around what this type of environment provides have also arisen. These ideals are increased privacy and independence for the patient, a chance for peer interaction, to be nursed by specially trained staff and to provide opportunities for adolescent patients to participate in their own care. This study used ethnography to gain a perspective of how ward space was used. Data were collected using participant observation and formal and informal interviews. Data were then analysed using the works of Lefebvre and Foucault. This study found that patient allocation, nursing observation and patient labels impact on how adolescent patients are nursed. Patients are expected to fit in, accepting all ministrations of nursing and staff. On this ward, nursing work was paramount. Nurses treated the adolescent patient like any other. In saying this, the adolescent patient still found ways to adapt to the ward space and its rules and routines; so in this sense, the ward still worked for them, even if nursing work was paramount. This study contributes to current discourse on the formation of specialized facilities in general, as it shows that no matter how a ward space is set up, if the space is not used in that way, then the purported purpose of that ward space will be lost.

The development of tourist attractiveness of Russian territories: modern trends and management practices

Directory of Open Access Journals (Sweden)

Elena Viktorovna Frolova

2016-03-01

Full Text Available The article is devoted to the actual problem of regional management - development of tourist at-tractiveness of Russian territories. The article discusses the concept of «tourist attractiveness», substantiates the author's position on its contents. Research methods include document analysis, opinion poll experts (heads of local authorities. On the basis of statistical and sociological data identified features and problems of tourism development in the Russian Federation in of objective and subjective indicators of the tourist infrastructure. Are determined dysfunction of modern ad-ministrative practices of tourism development in the Russian Federation, basic problems are revealed of realization program-target method of management in the modern state and regional policy. The article substantiates the concluded that the implementation of program-target method of tourist attractiveness associated with a number of shortcomings that limit their effectiveness. The authors identify the following main problems of implementation of the federal target program «Development of domestic tourism in the Russian Federation (2011-2018 years»: financial risks; declarative principle for selecting regions to participate in the federal program; target to achieve economic performance indicators, not to assess the long-term prospects of such aspects of the tourist attraction as the creation and / or development of unique tourist attraction, the image of the territory; high thresholds for co-financing of expenditure obligations for the implementation of the programs of regional budgets. On the basis of comparative analysis of the results of the survey population, and experts in the article highlights the main limitations of tourism development in the Russian Federation. The authors substantiates the need for the transformation of the state policy of direct intervention to indirect regulation model in tourism development. The article defines the main directions of

Gazettes sous influence : le Courrier du Bas-Rhin, la Gazette des Deux-Ponts et les sujets touchant la Russie vers 1770

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Georges Dulac

2016-11-01

Full Text Available Vers 1770, la campagne anti-russe du gouvernement français tend à dégrader l’image de la Russie, ce qui lèse gravement ses intérêts, notamment quand elle doit emprunter pour financer la guerre avec la Turquie. Aussi le prince Dmitri Alexeevitch Golitsyn, ministre plénipotentiaire à La Haye, se montre-t-il alors très actif sur ce terrain. Sa correspondance avec Pétersbourg témoigne de ses efforts, aux effets inégaux, pour influer sur les informations diffusées par quelques journaux : principalement le Courrier du Bas-Rhin, publié par Jean Manzon à Trèves, sous contrôle prussien, et dans une moindre mesure les deux Gazettes des Deux-Ponts, l’une politique, l’autre littéraire. Le journaliste de Trèves, qui trouve son intérêt à prendre le parti de la Russie, met en œuvre en sa faveur un discours journalistique abondant et parfois très élaboré. Cependant, la ligne du journal subit des fluctuations sensibles, selon l’évolution de la situation et à la suite de diverses interventions, dont celles du roi de Prusse et d’autre part de Stanislas-Auguste, qui pensionne un temps le journaliste. La Gazette des deux Ponts pratique l’information orientée avec plus de finesse, et, comme la gazette littéraire, accorde une large place à la matière russe : mais sur le plan politique, son traitement reste le plus souvent sous influence française et répond rarement aux vœux de D. A. Golitsyn.

Measures taken by the French Health Minister to ensure safety in radiotherapy treatments;Les mesures prises par la Ministre de la Sante pour assurer la securite des traitements en radiotherapie

Energy Technology Data Exchange (ETDEWEB)

Bachelot-Narquin, R. [Ministre de la Sante et des Sports, 75 - Paris (France)

2009-12-15

The objective of these measures is to restore the confidence of patients and professionals in an essential practice for the treatment of cancers and that is in constant progression. 70% of patients suffering of a cancer receive every year a radiotherapy. The national measures aim to strengthen the safety of practice, the quality of cares, the vigilance on the unwanted effects. among the measures we find in vivo dosimetry, doubling of radio physicists and then pass from 300 radio physicists in 2007 to 600 in 2012. (N.C.)

Talk of Francois Loos, delegate minister of industry, at the Meuse prefecture (Bar-le-Duc). Visit of the underground laboratory of research on the geologic disposal of radioactive wastes, Bure (Meuse)

International Nuclear Information System (INIS)

2005-01-01

In this talk, the French minister of industry recalls, first, the context of the management of radioactive wastes and the research programs launched in the framework of the 'Bataille' law from December 30, 1991. Then, he stresses on the importance of the work carried out so far in the three ways of research on radioactive wastes: separation/transmutation, deep underground disposal and long duration surface storage. He introduces the government will of organizing a public debate about the management of radioactive wastes before the preparation of the law project for the implementation of the technological and scientifical choices (the 'road-map') of France in the domain of radioactive wastes management. He stresses also on the importance of the financing warranties of this management and of the public information in this domain. He concludes on the economical support of the government in consideration of the regions that have accepted or would accept the setting up of waste management research laboratories and industrial facilities. (J.S.)

Scoring function to predict solubility mutagenesis

Directory of Open Access Journals (Sweden)

Deutsch Christopher

2010-10-01

Full Text Available Abstract Background Mutagenesis is commonly used to engineer proteins with desirable properties not present in the wild type (WT protein, such as increased or decreased stability, reactivity, or solubility. Experimentalists often have to choose a small subset of mutations from a large number of candidates to obtain the desired change, and computational techniques are invaluable to make the choices. While several such methods have been proposed to predict stability and reactivity mutagenesis, solubility has not received much attention. Results We use concepts from computational geometry to define a three body scoring function that predicts the change in protein solubility due to mutations. The scoring function captures both sequence and structure information. By exploring the literature, we have assembled a substantial database of 137 single- and multiple-point solubility mutations. Our database is the largest such collection with structural information known so far. We optimize the scoring function using linear programming (LP methods to derive its weights based on training. Starting with default values of 1, we find weights in the range [0,2] so that predictions of increase or decrease in solubility are optimized. We compare the LP method to the standard machine learning techniques of support vector machines (SVM and the Lasso. Using statistics for leave-one-out (LOO, 10-fold, and 3-fold cross validations (CV for training and prediction, we demonstrate that the LP method performs the best overall. For the LOOCV, the LP method has an overall accuracy of 81%. Availability Executables of programs, tables of weights, and datasets of mutants are available from the following web page: http://www.wsu.edu/~kbala/OptSolMut.html.

Development of a Regional Glycerol Dialkyl Glycerol Tetraether (GDGT) - Temperature Calibration for Antarctic and sub-Antarctic Lakes

Science.gov (United States)

Roberts, S. J.; Foster, L. C.; Pearson, E. J.; Steve, J.; Hodgson, D.; Saunders, K. M.; Verleyen, E.

2016-12-01

Temperature calibration models based on the relative abundances of sedimentary glycerol dialkyl glycerol tetraethers (GDGTs) have been used to reconstruct past temperatures in both marine and terrestrial environments, but have not been widely applied in high latitude environments. This is mainly because the performance of GDGT-temperature calibrations at lower temperatures and GDGT provenance in many lacustrine settings remains uncertain. To address these issues, we examined surface sediments from 32 Antarctic, sub-Antarctic and Southern Chilean lakes. First, we quantified GDGT compositions present and then investigated modern-day environmental controls on GDGT composition. GDGTs were found in all 32 lakes studied. Branched GDGTs (brGDGTs) were dominant in 31 lakes and statistical analyses showed that their composition was strongly correlated with mean summer air temperature (MSAT) rather than pH, conductivity or water depth. Second, we developed the first regional brGDGT-temperature calibration for Antarctic and sub-Antarctic lakes based on four brGDGT compounds (GDGT-Ib, GDGT-II, GDGT-III and GDGT-IIIb). Of these, GDGT-IIIb proved particularly important in cold lacustrine environments. Our brGDGT-Antarctic temperature calibration dataset has an improved statistical performance at low temperatures compared to previous global calibrations (r2=0.83, RMSE=1.45°C, RMSEP-LOO=1.68°C, n=36 samples), highlighting the importance of basing palaeotemperature reconstructions on regional GDGT-temperature calibrations, especially if specific compounds lead to improved model performance. Finally, we applied the new Antarctic brGDGT-temperature calibration to two key lake records from the Antarctic Peninsula and South Georgia. In both, downcore temperature reconstructions show similarities to known Holocene warm periods, providing proof of concept for the new Antarctic calibration model.

[Disorders of libido from the gynecological view point].

Science.gov (United States)

Eicher, W

1976-12-02

Sexual dysfunctions are differentiated according to the following symptoms: libido dysfunction, orgasmic dysfunction, vaginism, algopareunia and polysymptomatic dysfunction. In the out-patient service for sexual and other psychosomatic disorders of the University of Heidelberg's Women's Hospital 90 women with libido dysfunction were treated with conflict-centered psychotherapy after exclusion of organic diseases which could explain the reduction of libido and after exclusion of a depression where the loss of libido is a regular symptom. The success-rate was 63%. It was attempted to reinforce the ego of the patient which enables him to experience his surroundings with less conflicts. Neurotic anxieties and symptoms are decreased and loos their importance so that the patient is able to handle his sexual disturbance. Among the psychosocial factors, i.e. focal causes, responsible for the libido dysfunction we found: In 48% of the cases the relationship between parents and children had been disturbed, which caused difficulties in the identification process (lack of father or mother, cool mother, divorce, borken home). Problems with the partners were found in 42%. 2/3 of these women had not grown up in intact families, which seems to predestinate difficulties in communication later on. Psychodynamically the loss of libido means sexual resistance which can lead to aversion or disgust. When there is no excitement the vasocongestion and lubrication do not take place: cohabitation pain (algopareunia) results. On the other hand the reduction of libido can also be a result of chronic algopareunia, i.e. secondary. Psychogenic bleedings ("aversion-bleeding") during or after intercourse occasionally occur in combination with algopareunia and lack of libido.

An unbiased method to build benchmarking sets for ligand-based virtual screening and its application to GPCRs.

Science.gov (United States)

Xia, Jie; Jin, Hongwei; Liu, Zhenming; Zhang, Liangren; Wang, Xiang Simon

2014-05-27

Benchmarking data sets have become common in recent years for the purpose of virtual screening, though the main focus had been placed on the structure-based virtual screening (SBVS) approaches. Due to the lack of crystal structures, there is great need for unbiased benchmarking sets to evaluate various ligand-based virtual screening (LBVS) methods for important drug targets such as G protein-coupled receptors (GPCRs). To date these ready-to-apply data sets for LBVS are fairly limited, and the direct usage of benchmarking sets designed for SBVS could bring the biases to the evaluation of LBVS. Herein, we propose an unbiased method to build benchmarking sets for LBVS and validate it on a multitude of GPCRs targets. To be more specific, our methods can (1) ensure chemical diversity of ligands, (2) maintain the physicochemical similarity between ligands and decoys, (3) make the decoys dissimilar in chemical topology to all ligands to avoid false negatives, and (4) maximize spatial random distribution of ligands and decoys. We evaluated the quality of our Unbiased Ligand Set (ULS) and Unbiased Decoy Set (UDS) using three common LBVS approaches, with Leave-One-Out (LOO) Cross-Validation (CV) and a metric of average AUC of the ROC curves. Our method has greatly reduced the "artificial enrichment" and "analogue bias" of a published GPCRs benchmarking set, i.e., GPCR Ligand Library (GLL)/GPCR Decoy Database (GDD). In addition, we addressed an important issue about the ratio of decoys per ligand and found that for a range of 30 to 100 it does not affect the quality of the benchmarking set, so we kept the original ratio of 39 from the GLL/GDD.

High dose radiation damage in nuclear energy structural materials investigated by heavy ion irradiation simulation

International Nuclear Information System (INIS)

Zheng Yongnan; Xu Yongjun; Yuan Daqing

2014-01-01

Structural materials in ITER, ADS and fast reactor suffer high dose irradiations of neutrons and/or protons, that leads to severe displacement damage up to lOO dpa per year. Investigation of radiation damage induced by such a high dose irradiation has attracted great attention along with the development of nuclear energy facilities of new generation. However, it is deeply hampered for the lacking of high dose neutron and proton sources. Irradiation simulation of heavy ions produced by accelerators opens up an effective way for laboratory investigation of high dose irradiation induced radiation damage encountered in the ITER, ADS, etc. Radiation damage is caused mainly by atomic displacement in materials. The displacement rate of heavy ions is about lO 3 ∼10 7 orders higher than those of neutrons and protons. High displacement rate of heavy ions significantly reduces the irradiation time. The heavy ion irradiation simulation technique (HIIS) technique has been developed at China Institute of Atomic Energy and a series of the HIIS experiments have been performed to investigate radiation damage in stainless steels, tungsten and tantalum at irradiation temperatures from room temperature to 800 ℃ and in the irradiation dose region up to 100 dpa. The experimental results show that he radiation swelling peak for the modified stainless steel appears in the temperature region around 580 ℃ and the radiation damage is more sensitive to the temperature, the size of the radiation induced vacancy cluster or void increase with the increasing of the irradiation dose, and among the three materials the home-made modified stainless steel has the best radiation resistant property. (authors)

Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets

Science.gov (United States)

Shahin, Rand; Swellmeen, Lubna; Shaheen, Omar; Aboalhaija, Nour; Habash, Maha

2016-01-01

Targeting Proviral integration-site of murine Moloney leukemia virus 1 kinase, hereafter called Pim-1 kinase, is a promising strategy for treating different kinds of human cancer. Headed for this a total list of 328 formerly reported Pim-1 kinase inhibitors has been explored and divided based on the pharmacophoric features of the most active molecules into 10 subsets projected to represent potential active binding manners accessible to ligands within the binding pocket of Pim-1 kinase. Discovery Studio 4.1 (DS 4.1) was employed to detect potential pharmacophoric active binding manners anticipated by Pim-1 Kinase inhibitors. The pharmacophoric models were then allowed to compete within Quantitative Structure Activity Relationship (QSAR) framework with other 2D descriptors. Accordingly Genetic algorithm and multiple linear regression investigation were engaged to find the finest QSAR equation that has the best predictive power r 262 2 = 0.70, F = 119.14, r LOO 2 = 0.693, r PRESS 2 against 66 external test inhibitors = 0.71 q2 = 0.55. Three different pharmacophores appeared in the successful QSAR equation this represents three different binding modes for inhibitors within the Pim-1 kinase binding pocket. Pharmacophoric models were later used to screen compounds within the National Cancer Institute database. Several low micromolar Pim-1 Kinase inhibitors were captured. The most potent hits show IC50 values of 0.77 and 1.03 µM. Also, upon analyzing the successful QSAR Equation we found that some polycyclic aromatic electron-rich structures namely 6-Chloro-2-methoxy-acridine can be considered as putative hits for Pim-1 kinase inhibition.

La Actividad Productiva de la Fábrica de Harinas “La Montserrat” (Girona en el Año Agrícola de 1903-1904

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Helena Benito Mundet

2005-06-01

Full Text Available La fábrica La Montserrat fue construida en Girona en el año 1898 por José Ensesa y Cía. Sociedad en Comandita, que se dedicaba al comercio de cereales y a la fabricación de harinas. Con el objetivo de determinar cómo se estructuraba la actividad productiva de la empresa hemos estudiado con detalle las operaciones que realizó durante el año agrícola 1903-1904. Nos centramos en tres aspectos principales: el del aprovisionamiento de trigo (procedencia, transporte, precios, la producción de harina (de trigos propios y ajenos, rendimientos y su distribución (clientes, destino de la harina. Por último, también hemos analizado la cuenta de pérdidas y ganancias, que es en definitiva la que nos indicará su rentabilidad. Palabras clave: historia de la contabilidad, trigos y harinas, actividad productiva.Harinera La Montserrat, S.A, a company involved in the manufacturing and trading of cereals and flour, was founded in Girona in 1898 by José Ensesa y Cía., Sociedad en Comandita. With the objective to determine how the product activity of this business was structured, we have studied in detail the operations that were carried out over the agricultural year 1903-1904. We have focused on three main aspects. Firstly, the purchasing of wheat (origin, transportation, prices; secondly, the production of flour (using internal and external wheat, profits; and thirdly, its distribution (customers, destination. Finally, we have analyzed the profit and loos account for this period in order tofind out if this business was profitable.

COOPERATIVAS DE CRÉDITO Y BANCA SOCIAL: VIEJAS Y NUEVAS RESPUESTAS ÉTICAS Y SOLIDARIAS A PROBLEMAS DE SIEMPRE / CREDIT COOPERATIVES AND SOCIAL BANKING: OLD AND NEW ETHICAL AND SOLIDARITY RESPONSES TO USUAL PROBLEMS

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Amparo MELIÁN NAVARRO

2012-09-01

Full Text Available Entre el origen de las cooperativas de crédito y la nueva “banca social” median unos cien años, en los que los sistemas bancarios han sufrido una transformación extraordinaria. A pesar de sus diferencias, ambos tipos de instituciones surgieron por unos motivos semejantes: la exclusión financiera de colectivos vulnerables y la necesidad de respuestas éticas, solidarias y responsables. Esas necesidades han cobrado protagonismo con la actual crisis financiera, económica y social, en la que se aprecia un deterioro de los valores elementales y, en consecuencia, una extensión del descrédito de las entidades bancarias. En esta situación, se revaloriza el papel del crédito cooperativo y de la “banca social”, instrumentos que, por sus especiales características, se han visto menos afectadas por la pérdida de reputación y se abren paso como alternativas. / Between the credit cooperatives origin and new social banking have passed by a century, in which banking systems have going through an extraordinary change. Despite their differences, both kinds of companies come up by similar reasons: Financial exclusion of vulnerable collectives and need of ethical, responsible and solidary responses. These needs have gain prominence in the present social and financial-economic crisis, in which a basic values deterioration and accordingly a growing essential values deterioration. In this situation increase the social banking and cooperative credit role. These tools have been less affected by loos of reputation because of their especial features and breaking through as new credit ways.

Investigations of Structural Requirements for BRD4 Inhibitors through Ligand- and Structure-Based 3D QSAR Approaches

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Adeena Tahir

2018-06-01

Full Text Available The bromodomain containing protein 4 (BRD4 recognizes acetylated histone proteins and plays numerous roles in the progression of a wide range of cancers, due to which it is under intense investigation as a novel anti-cancer drug target. In the present study, we performed three-dimensional quantitative structure activity relationship (3D-QSAR molecular modeling on a series of 60 inhibitors of BRD4 protein using ligand- and structure-based alignment and different partial charges assignment methods by employing comparative molecular field analysis (CoMFA and comparative molecular similarity indices analysis (CoMSIA approaches. The developed models were validated using various statistical methods, including non-cross validated correlation coefficient (r2, leave-one-out (LOO cross validated correlation coefficient (q2, bootstrapping, and Fisher’s randomization test. The highly reliable and predictive CoMFA (q2 = 0.569, r2 = 0.979 and CoMSIA (q2 = 0.500, r2 = 0.982 models were obtained from a structure-based 3D-QSAR approach using Merck molecular force field (MMFF94. The best models demonstrate that electrostatic and steric fields play an important role in the biological activities of these compounds. Hence, based on the contour maps information, new compounds were designed, and their binding modes were elucidated in BRD4 protein’s active site. Further, the activities and physicochemical properties of the designed molecules were also predicted using the best 3D-QSAR models. We believe that predicted models will help us to understand the structural requirements of BRD4 protein inhibitors that belong to quinolinone and quinazolinone classes for the designing of better active compounds.

Forecasting solar radiation using an optimized hybrid model by Cuckoo Search algorithm

International Nuclear Information System (INIS)

Wang, Jianzhou; Jiang, He; Wu, Yujie; Dong, Yao

2015-01-01

Due to energy crisis and environmental problems, it is very urgent to find alternative energy sources nowadays. Solar energy, as one of the great potential clean energies, has widely attracted the attention of researchers. In this paper, an optimized hybrid method by CS (Cuckoo Search) on the basis of the OP-ELM (Optimally Pruned Extreme Learning Machine), called CS-OP-ELM, is developed to forecast clear sky and real sky global horizontal radiation. First, MRSR (Multiresponse Sparse Regression) and LOO-CV (leave-one-out cross-validation) can be applied to rank neurons and prune the possibly meaningless neurons of the FFNN (Feed Forward Neural Network), respectively. Then, Direct strategy and Direct-Recursive strategy based on OP-ELM are introduced to build a hybrid model. Furthermore, CS (Cuckoo Search) optimized algorithm is employed to determine the proper weight coefficients. In order to verify the effectiveness of the developed method, hourly solar radiation data from six sites of the United States has been collected, and methods like ARMA (Autoregression moving average), BP (Back Propagation) neural network and OP-ELM can be compared with CS-OP-ELM. Experimental results show the optimized hybrid method CS-OP-ELM has the best forecasting performance. - Highlights: • An optimized hybrid method called CS-OP-ELM is proposed to forecast solar radiation. • CS-OP-ELM adopts multiple variables dataset as input variables. • Direct and Direct-Recursive strategy are introduced to build a hybrid model. • CS (Cuckoo Search) algorithm is used to determine the optimal weight coefficients. • The proposed method has the best performance compared with other methods

Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds

International Nuclear Information System (INIS)

Helguera, Aliuska Morales; Cordeiro, M. Natalia D.S.; Perez, Miguel Angel Cabrera; Combes, Robert D.; Gonzalez, Maykel Perez

2008-01-01

In this work, Quantitative Structure-Activity Relationship (QSAR) modelling was used as a tool for predicting the carcinogenic potency of a set of 39 nitroso-compounds, which have been bioassayed in male rats by using the oral route of administration. The optimum QSAR model provided evidence of good fit and performance of predicitivity from training set. It was able to account for about 84% of the variance in the experimental activity and exhibited high values of the determination coefficients of cross validations, leave one out and bootstrapping (q 2 LOO = 78.53 and q 2 Boot = 74.97). Such a model was based on spectral moments weighted with Gasteiger-Marsilli atomic charges, polarizability and hydrophobicity, as well as with Abraham indexes, specifically the summation solute hydrogen bond basicity and the combined dipolarity/polarizability. This is the first study to have explored the possibility of combining Abraham solute descriptors with spectral moments. A reasonable interpretation of these molecular descriptors from a toxicological point of view was achieved by means of taking into account bond contributions. The set of relationships so derived revealed the importance of the length of the alkyl chains for determining carcinogenic potential of the chemicals analysed, and were able to explain the difference between mono-substituted and di-substituted nitrosoureas as well as to discriminate between isomeric structures with hydroxyl-alkyl and alkyl substituents in different positions. Moreover, they allowed the recognition of structural alerts in classical structures of two potent nitrosamines, consistent with their biotransformation. These results indicate that this new approach has the potential for improving carcinogenicity predictions based on the identification of structural alerts

Quick detection and quantification of iron-cyanide complexes using fourier transform infrared spectroscopy.

Science.gov (United States)

Sut-Lohmann, Magdalena; Raab, Thomas

2017-08-01

The continuous release of persistent iron-cyanide (Fe-CN) complexes from various industrial sources poses a high hazard to the environment and indicates the necessity to analyze a considerable amount of samples. Conventional flow injection analysis (FIA) is a time and cost consuming method for cyanide (CN) determination. Thus, a rapid and economic alternative needs to be developed to quantify the Fe-CN complexes. 52 soil samples were collected at a former Manufactured Gas Plant (MGP) site in order to determine the feasibility of diffuse reflectance infrared Fourier spectroscopy (DRIFTS). Soil analysis revealed CN concentrations in a range from 8 to 14.809 mg kg -1 , where 97% was in the solid form (Fe 4 [Fe(CN) 6 ] 3 ), which is characterized by a single symmetrical CN band in the range 2092-2084 cm -1 . The partial least squares (PLS) calibration-validation model revealed IR response to CN tot which exceeds 2306 mg kg -1 (limit of detection, LOD). Leave-one-out cross-validation (LOO-CV) was performed on soil samples, which contained low CN tot ( 900 mg kg -1 resulted in LOD equal to 3751 mg kg -1 . It was found that FTIR spectroscopy provides the information concerning different CN species in the soil samples. Additionally, it is suitable for quantifying Fe-CN species in matrixes with CN tot  > 154 mg kg -1 . Thus, FTIR spectroscopy, in combination with the statistical approach applied here seems to be a feasible and quick method for screening of contaminated sites. Copyright © 2017 Elsevier Ltd. All rights reserved.

Fuel gases generation in the primary contention during a coolant loss accident in a nuclear power plant with reactor type BWR

International Nuclear Information System (INIS)

Salaices, M.; Salaices, E.; Ovando, R.; Esquivias, J.

2011-11-01

During an accident design base of coolant loos, the hydrogen gas can accumulate inside the primary contention as a result of several generation mechanisms among those that are: 1) the reaction metal-water involving the zirconium of the fuel cladding and the reactor coolant, 2) the metals corrosion for the solutions used in the emergency cooling and dew of the contention, and 3) the radio-decomposition of the cooling solutions of post-accident emergency. In this work the contribution of each generation mechanism to the hydrogen total in the primary contention is analyzed, considering typical inventories of zirconium, zinc, aluminum and fission products in balance cycle of a reactor type BWR. In the analysis the distribution model of fission products and hydrogen production proposed in the regulator guide 1.7, Rev. 2 of the US NRC was used. The results indicate that the mechanism that more contributes to the hydrogen generation at the end of a period of 24 hours of initiate the accident is the radio-decomposition of the cooling solutions of post-accident emergency continued by the reaction metal-water involving the zirconium of the fuel cladding with the reactor coolant, and lastly the aluminum and zinc oxidation present in the primary contention. However, the reaction metal-water involving the zirconium of the fuel cladding and the reactor coolant is the mechanism that more contributes to the hydrogen generation in the first moments after the accident. This study constitutes the first part of the general analysis of the generation, transport and control of fuel gases in the primary contention during a coolant loss accident in BWRs. (Author)

Book Reviews

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Redactie KITLV

1972-04-01

Full Text Available - P.E. de Josselin de Jong, Vincent Monteil, Indonésie. Collection “Hommes et civilisations.” Horizons de France, 1970. 287 p., 280 plates (36 in colour. - H. Aveling, Burton Raffel, The forked tongue: A study of the translation process. (De proprietatibus Litterarum, series maior, 14. Mouton, The Hague and Paris 1971. 181 pp. - A. Teeuw, David H. de Queljoe, A preliminary study of some phonetic features of Petani, with glossaries. Special Report Series Number 5. Center for Southeast Asian Studies. Northern Illinois University, DeKalb, Illinois. Macrh 1971. XIII and 114 pp. - E. Postel-Coster, Kirk Michael Endicott, An analysis of Malay magic. Oxford Monographs on Social Anthropology, Oxford 1970. 188 pp. - Thé Siauw Giap, Mahathir bin Mohamad, The Malay Dilemma. Donald Moore for the Asia Pacific Press Pte Ltd, Singapore 1970. vi, 188 p. - P.D. de Josselin de Jong, Thomas J. Bellows, The People’s action party of Singapore. The energence of a dominant party system. Monograph Series No. 14, Yale University Southeast Asia Series. New Haven, Conn. 1970. 195 blz. - J.H. Maronier, J. de Loos-Haaxman, Dagwerk in Indië. Hommage aan het verstild verleden. F. Wever. Franeker. 103 bldz., 114 ill. in de tekst, 12 gekl. ill. in insteekmap. - P.H. Pott, Albert le Bonheur, La sculpture indonésienne au Musée Guimet. Catalogue et étude iconographique. Paris, Presses universitaires de France, 1971, oblong, 4to, 360 p., vele platen. - J.J.M. Taeymans, J. Innes Miller, The spice trade of the Roman Empire, 29 B.C. - A.D. 641. Clarendon Press: Oxford University Press, Oxford 1969. 294 p., 4 plates, 9 maps. - ,

Declaration from the prime minister, Dominique de Villepin, about the energy policy on May 15, 2006; Declaration du premier ministre, Dominique de Villepin sur la politique energetique, le 15 mai 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

While the oil barrel has exceeded the historical price of 70$, the French government has put forward two exigencies: reducing the weight of the oil bill and reinforcing France's energy independence through the development of nuclear and renewable energies and with the implementation of an energy saving policy, and sharing in an equitable way the petroleum 'weight' taking into account the situation of oil-dependent professionals. In this communication, the prime minister develops the different point of this policy, in particular the financial incentives for the development of renewable energy sources, biofuels, and public transportation systems, and the measures allowing to protect the spending power of French people. (J.S.)

Hypoxia-ischemia and retinal ganglion cell damage

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Charanjit Kaur

2008-08-01

Full Text Available Charanjit Kaur1, Wallace S Foulds2, Eng-Ang Ling11Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Singapore Eye Research Institute, SingaporeAbstract: Retinal hypoxia is the potentially blinding mechanism underlying a number of sight-threatening disorders including central retinal artery occlusion, ischemic central retinal vein thrombosis, complications of diabetic eye disease and some types of glaucoma. Hypoxia is implicated in loss of retinal ganglion cells (RGCs occurring in such conditions. RGC death occurs by apoptosis or necrosis. Hypoxia-ischemia induces the expression of hypoxia inducible factor-1α and its target genes such as vascular endothelial growth factor (VEGF and nitric oxide synthase (NOS. Increased production of VEGF results in disruption of the blood retinal barrier leading to retinal edema. Enhanced expression of NOS results in increased production of nitric oxide which may be toxic to the cells resulting in their death. Excess glutamate release in hypoxic-ischemic conditions causes excitotoxic damage to the RGCs through activation of ionotropic and metabotropic glutamate receptors. Activation of glutamate receptors is thought to initiate damage in the retina by a cascade of biochemical effects such as neuronal NOS activation and increase in intracellular Ca2+ which has been described as a major contributing factor to RGC loss. Excess production of proinflammatory cytokines also mediates cell damage. Besides the above, free-radicals generated in hypoxic-ischemic conditions result in RGC loss because of an imbalance between antioxidant- and oxidant-generating systems. Although many advances have been made in understanding the mediators and mechanisms of injury, strategies to improve the damage are lacking. Measures to prevent neuronal injury have to be developed.Keywords: retinal hypoxia, retinal ganglion cells, glutamate receptors, neuronal injury, retina

Speciation of Selenium in Selenium-Enriched Sunflower Oil by High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry/Electrospray-Orbitrap Tandem Mass Spectrometry.

Science.gov (United States)

Bierla, Katarzyna; Flis-Borsuk, Anna; Suchocki, Piotr; Szpunar, Joanna; Lobinski, Ryszard

2016-06-22

The reaction of sunflower oil with selenite produces a complex mixture of selenitriglycerides with antioxidant and anticancer properties. To obtain insight into the identity and characteristics of the species formed, an analytical approach based on the combination of high-performance liquid chromatography (HPLC) with (78)Se-specific selenium detection by inductively coupled plasma mass spectrometry (ICP MS) and high-resolution (100 000), high mass accuracy (HPLC-ICP MS for the separation of a complex mixture of selenospecies and a mathematical correction of the background signal was developed. The identical chromatographic conditions served for the sample introduction into electrospray MS. Two types of samples were analyzed: sunflower oil dissolved in isopropanol and methanol extract of the oil containing 65% selenium. HPLC-ICP MS showed 14 peaks, 11 of which could also be detected in the methanol extract. Isotopic patterns corresponding to molecules with one or two selenium atoms could be attributed by Orbitrap MS at the retention times corresponding to the HPLC-ICP MS peak apexes. Structural data for these species were acquired by MS(2) and MS(3) fragmentation of protonated or sodiated ions using high-energy collisional dissociation (HCD). A total of 11 selenium-containing triglycerol derivatives resulting from the oxidation of one or two double bonds of linoleic acid and analogous derivatives of glycerol-mixed linoleate(s)/oleinate(s) have been identified for the first time. The presence of these species was confirmed by the targeted analysis in the total oil isopropanol solution. Their identification corroborated the predicted elution order in reversed-phase chromatography: LLL (glycerol trilinoleate), LLO (glycerol dilinoleate-oleinate), LOO (glycerol linoleate-dioleinate), OOO (glycerol trioleinate), of which the extrapolation allowed for the prediction of the identity [glycerol dioleinate-stearate (OOS) and glycerol oleinate-distearate (OSS)] of the

Computer modeling of the optical properties and heating of spherical gold and silica-gold nanoparticles for laser combined imaging and photothermal treatment

International Nuclear Information System (INIS)

Pustovalov, V; Astafyeva, L; Jean, B

2009-01-01

Recently, several groups of investigators (Anderson, Halas, Zharov, El-Sayed and their co-workers (Pitsillides et al 2003 Biophys. J. 84 4023-31, Zharov et al 2003 Appl. Phys. Lett. 83 4897-9, Zharov et al 2004 Proc. SPIE 5319 291-9, Loo et al 2005 Nano Lett. 5 709-11, Gobin et al 2007 Nano Lett. 7 1929-34, Fu et al 2008 Nanotechnology 19 045103, Huang et al 2006 J. Am. Chem. Soc. 128 2115-20, Jain et al 2006 J. Phys. Chem. B 110 7238-48, Jain et al 2007 Nano Today 2 18-29)) demonstrated, through pioneering results, the great potential of laser thermal therapy of cells and tissues conjugated with gold nanoparticles. It was also proposed to use combined diagnostics and therapy on the basis of nanoparticle selection for achievement of efficient contrast for laser imaging applications, as well as for photothermal therapy. However, the current understanding of the relationship between optical properties (absorption, backscattering) of nanoparticles, the efficiency of nanoparticle heating and the possibility to use them for combined imaging and therapy is limited. Here, we report the results of computer modeling of optical absorption and backscattering properties and laser heating of gold and silica-gold spherical nanoparticles for laser combined imaging and photothermal treatment of cells and tissues conjugated with nanoparticles. The efficiencies of nanoparticle heating and backscattering by nanoparticles, depending upon their radii, structure and optical properties of the metal, were investigated. This paper focuses on the analysis and determination of appropriate ranges of nanoparticle sizes for the purposes of laser combined imaging and photothermal treatment. The possibility to use spherical gold and silica-gold nanoparticles in determined ranges of radii for these purposes for laser wavelengths 532 and 800 nm is investigated.

WE-D-BRE-05: Prediction of Late Radiation-Induced Proctitis in Prostate Cancer Patients Using Chromosome Aberration and Cell Proliferation Rate

Energy Technology Data Exchange (ETDEWEB)

Oh, J; Deasy, J [Memorial Sloan Kettering Cancer Center, New York, NY (United States)

2014-06-15

Purpose: Chromosome damage and cell proliferation rate have been investigated as potential biomarkers for the early prediction of late radiationinduced toxicity. Incorporating these endpoints, we explored the predictive power for late radiation proctitis using a machine learning method. Methods: Recently, Beaton et al. showed that chromosome aberration and cell proliferation rate could be used as biomarkers to predict late radiation proctitis (Beaton et al. (2013) Int J Rad Onc Biol Phys, 85:1346–1352). For the identification of radiosensitive biomarkers, blood samples were collected from 10 patients with grade 3 late proctitis along with 20 control patients with grade 0 proctitis. After irradiation at 6 Gy, statistically significant difference was observed between the two groups, using the number of dicentrics and excess fragments, and the number of cells in metaphase 2 (M2). However, Beaton et al. did not show the usefulness of combining these endpoints. We reanalyzed the dataset to investigate whether incorporating these endpoints can increase the predictive power of radiation proctitis, using a support vector machine (SVM). Results: Using the SVM method with the number of fragments and M2 endpoints, perfect classification was achieved. In addition, to avoid biased estimate of the classification method, leave-one-out cross-validation (LOO-CV) was performed. The best performance was achieved when all three endpoints were used with 87% accuracy, 90% sensitivity, 85% specificity, and 0.85 AUC (the area under the receiver operating characteristic (ROC) curve). The most significant endpoint was the number of fragments that obtained 83% accuracy, 70% sensitivity, 90% specificity, and 0.82 AUC. Conclusion: We demonstrated that chromosome damage and cell proliferation rate could be significant biomarkers to predict late radiation proctitis. When these endpoints were used together in conjunction with a machine learning method, the better performance was obtained

SU-C-BRE-06: Radiobiological Advantage of Very Rapid Irradiation

Energy Technology Data Exchange (ETDEWEB)

Rafat, M; Bazalova, M; Palma, B; Kozak, M; Jiang, D; Lartey, F; Graves, E; Koong, A; Maxim, P; Loo, B [Stanford University, Stanford, CA (United States); Dunning, M; McCormick, D; Nelson, J; Hemsing, E [SLAC National Accelerator Laboratory, Menlo Park, CA (United States)

2014-06-15

Purpose: To characterize the effect of very rapid dose delivery as compared to conventional therapeutic irradiation times on clonogenic cell survival. Methods: We used a Varian Trilogy linear accelerator to deliver doses up to 10 Gy using a 6 MV SRS photon beam. We irradiated four cancer cell lines in times ranging from 30 sec to 30 min. We also used a Varian TrueBeam linear accelerator to deliver 9 MeV electrons at 10 Gy in 10 s to 30 min to determine the effect of irradiation time on cell survival. We then evaluated the effect of using 60 and 120 MeV electrons on cell survival using the Next Linear Collider Test Accelerator (NLCTA) beam line at the SLAC National Accelerator Laboratory. During irradiation, adherent cells were maintained at 37oC with 20%O2/5%CO2. Clonogenic assays were completed following irradiation to determine changes in cell survival due to dose delivery time and beam quality, and the survival data were fitted with the linear-quadratic model. Results: Cell lines varied in radiosensitivity, ranging from two to four logs of cell kill at 10 Gy for both conventional and very rapid irradiation. Delivering radiation in shorter times decreased survival in all cell lines. Log differences in cell kill ranged from 0.2 to 0.7 at 10 Gy for the short compared to the long irradiation time. Cell kill differences between short and long irradiations were more pronounced as doses increased for all cell lines. Conclusion: Our findings suggest that shortening delivery of therapeutic radiation doses to less than 1 minute may improve tumor cell kill. This study demonstrates the potential advantage of technologies under development to deliver stereotactic ablative radiation doses very rapidly. Bill Loo and Peter Maxim have received Honoraria from Varian and Research Support from Varian and RaySearch.

Focal liver lesions segmentation and classification in nonenhanced T2-weighted MRI.

Science.gov (United States)

Gatos, Ilias; Tsantis, Stavros; Karamesini, Maria; Spiliopoulos, Stavros; Karnabatidis, Dimitris; Hazle, John D; Kagadis, George C

2017-07-01

To automatically segment and classify focal liver lesions (FLLs) on nonenhanced T2-weighted magnetic resonance imaging (MRI) scans using a computer-aided diagnosis (CAD) algorithm. 71 FLLs (30 benign lesions, 19 hepatocellular carcinomas, and 22 metastases) on T2-weighted MRI scans were delineated by the proposed CAD scheme. The FLL segmentation procedure involved wavelet multiscale analysis to extract accurate edge information and mean intensity values for consecutive edges computed using horizontal and vertical analysis that were fed into the subsequent fuzzy C-means algorithm for final FLL border extraction. Texture information for each extracted lesion was derived using 42 first- and second-order textural features from grayscale value histogram, co-occurrence, and run-length matrices. Twelve morphological features were also extracted to capture any shape differentiation between classes. Feature selection was performed with stepwise multilinear regression analysis that led to a reduced feature subset. A multiclass Probabilistic Neural Network (PNN) classifier was then designed and used for lesion classification. PNN model evaluation was performed using the leave-one-out (LOO) method and receiver operating characteristic (ROC) curve analysis. The mean overlap between the automatically segmented FLLs and the manual segmentations performed by radiologists was 0.91 ± 0.12. The highest classification accuracies in the PNN model for the benign, hepatocellular carcinoma, and metastatic FLLs were 94.1%, 91.4%, and 94.1%, respectively, with sensitivity/specificity values of 90%/97.3%, 89.5%/92.2%, and 90.9%/95.6% respectively. The overall classification accuracy for the proposed system was 90.1%. Our diagnostic system using sophisticated FLL segmentation and classification algorithms is a powerful tool for routine clinical MRI-based liver evaluation and can be a supplement to contrast-enhanced MRI to prevent unnecessary invasive procedures. © 2017 American

Classification of Malaysia aromatic rice using multivariate statistical analysis

Energy Technology Data Exchange (ETDEWEB)

Abdullah, A. H.; Adom, A. H.; Shakaff, A. Y. Md; Masnan, M. J.; Zakaria, A.; Rahim, N. A. [School of Mechatronic Engineering, Universiti Malaysia Perlis, Kampus Pauh Putra, 02600 Arau, Perlis (Malaysia); Omar, O. [Malaysian Agriculture Research and Development Institute (MARDI), Persiaran MARDI-UPM, 43400 Serdang, Selangor (Malaysia)

2015-05-15

Aromatic rice (Oryza sativa L.) is considered as the best quality premium rice. The varieties are preferred by consumers because of its preference criteria such as shape, colour, distinctive aroma and flavour. The price of aromatic rice is higher than ordinary rice due to its special needed growth condition for instance specific climate and soil. Presently, the aromatic rice quality is identified by using its key elements and isotopic variables. The rice can also be classified via Gas Chromatography Mass Spectrometry (GC-MS) or human sensory panels. However, the uses of human sensory panels have significant drawbacks such as lengthy training time, and prone to fatigue as the number of sample increased and inconsistent. The GC–MS analysis techniques on the other hand, require detailed procedures, lengthy analysis and quite costly. This paper presents the application of in-house developed Electronic Nose (e-nose) to classify new aromatic rice varieties. The e-nose is used to classify the variety of aromatic rice based on the samples odour. The samples were taken from the variety of rice. The instrument utilizes multivariate statistical data analysis, including Principal Component Analysis (PCA), Linear Discriminant Analysis (LDA) and K-Nearest Neighbours (KNN) to classify the unknown rice samples. The Leave-One-Out (LOO) validation approach is applied to evaluate the ability of KNN to perform recognition and classification of the unspecified samples. The visual observation of the PCA and LDA plots of the rice proves that the instrument was able to separate the samples into different clusters accordingly. The results of LDA and KNN with low misclassification error support the above findings and we may conclude that the e-nose is successfully applied to the classification of the aromatic rice varieties.

Detection of Driver Drowsiness Using Wavelet Analysis of Heart Rate Variability and a Support Vector Machine Classifier

Directory of Open Access Journals (Sweden)

Gang Li

2013-12-01

Full Text Available Driving while fatigued is just as dangerous as drunk driving and may result in car accidents. Heart rate variability (HRV analysis has been studied recently for the detection of driver drowsiness. However, the detection reliability has been lower than anticipated, because the HRV signals of drivers were always regarded as stationary signals. The wavelet transform method is a method for analyzing non-stationary signals. The aim of this study is to classify alert and drowsy driving events using the wavelet transform of HRV signals over short time periods and to compare the classification performance of this method with the conventional method that uses fast Fourier transform (FFT-based features. Based on the standard shortest duration for FFT-based short-term HRV evaluation, the wavelet decomposition is performed on 2-min HRV samples, as well as 1-min and 3-min samples for reference purposes. A receiver operation curve (ROC analysis and a support vector machine (SVM classifier are used for feature selection and classification, respectively. The ROC analysis results show that the wavelet-based method performs better than the FFT-based method regardless of the duration of the HRV sample that is used. Finally, based on the real-time requirements for driver drowsiness detection, the SVM classifier is trained using eighty FFT and wavelet-based features that are extracted from 1-min HRV signals from four subjects. The averaged leave-one-out (LOO classification performance using wavelet-based feature is 95% accuracy, 95% sensitivity, and 95% specificity. This is better than the FFT-based results that have 68.8% accuracy, 62.5% sensitivity, and 75% specificity. In addition, the proposed hardware platform is inexpensive and easy-to-use.

Classification of Malaysia aromatic rice using multivariate statistical analysis

Science.gov (United States)

Abdullah, A. H.; Adom, A. H.; Shakaff, A. Y. Md; Masnan, M. J.; Zakaria, A.; Rahim, N. A.; Omar, O.

2015-05-01

Aromatic rice (Oryza sativa L.) is considered as the best quality premium rice. The varieties are preferred by consumers because of its preference criteria such as shape, colour, distinctive aroma and flavour. The price of aromatic rice is higher than ordinary rice due to its special needed growth condition for instance specific climate and soil. Presently, the aromatic rice quality is identified by using its key elements and isotopic variables. The rice can also be classified via Gas Chromatography Mass Spectrometry (GC-MS) or human sensory panels. However, the uses of human sensory panels have significant drawbacks such as lengthy training time, and prone to fatigue as the number of sample increased and inconsistent. The GC-MS analysis techniques on the other hand, require detailed procedures, lengthy analysis and quite costly. This paper presents the application of in-house developed Electronic Nose (e-nose) to classify new aromatic rice varieties. The e-nose is used to classify the variety of aromatic rice based on the samples odour. The samples were taken from the variety of rice. The instrument utilizes multivariate statistical data analysis, including Principal Component Analysis (PCA), Linear Discriminant Analysis (LDA) and K-Nearest Neighbours (KNN) to classify the unknown rice samples. The Leave-One-Out (LOO) validation approach is applied to evaluate the ability of KNN to perform recognition and classification of the unspecified samples. The visual observation of the PCA and LDA plots of the rice proves that the instrument was able to separate the samples into different clusters accordingly. The results of LDA and KNN with low misclassification error support the above findings and we may conclude that the e-nose is successfully applied to the classification of the aromatic rice varieties.

Classification of Malaysia aromatic rice using multivariate statistical analysis

International Nuclear Information System (INIS)

Abdullah, A. H.; Adom, A. H.; Shakaff, A. Y. Md; Masnan, M. J.; Zakaria, A.; Rahim, N. A.; Omar, O.

2015-01-01

Aromatic rice (Oryza sativa L.) is considered as the best quality premium rice. The varieties are preferred by consumers because of its preference criteria such as shape, colour, distinctive aroma and flavour. The price of aromatic rice is higher than ordinary rice due to its special needed growth condition for instance specific climate and soil. Presently, the aromatic rice quality is identified by using its key elements and isotopic variables. The rice can also be classified via Gas Chromatography Mass Spectrometry (GC-MS) or human sensory panels. However, the uses of human sensory panels have significant drawbacks such as lengthy training time, and prone to fatigue as the number of sample increased and inconsistent. The GC–MS analysis techniques on the other hand, require detailed procedures, lengthy analysis and quite costly. This paper presents the application of in-house developed Electronic Nose (e-nose) to classify new aromatic rice varieties. The e-nose is used to classify the variety of aromatic rice based on the samples odour. The samples were taken from the variety of rice. The instrument utilizes multivariate statistical data analysis, including Principal Component Analysis (PCA), Linear Discriminant Analysis (LDA) and K-Nearest Neighbours (KNN) to classify the unknown rice samples. The Leave-One-Out (LOO) validation approach is applied to evaluate the ability of KNN to perform recognition and classification of the unspecified samples. The visual observation of the PCA and LDA plots of the rice proves that the instrument was able to separate the samples into different clusters accordingly. The results of LDA and KNN with low misclassification error support the above findings and we may conclude that the e-nose is successfully applied to the classification of the aromatic rice varieties

Mental resilience, perceived immune functioning, and health

Directory of Open Access Journals (Sweden)

Van Schrojenstein Lantman M

2017-03-01

Full Text Available Marith Van Schrojenstein Lantman,1 Marlou Mackus,1 Leila S Otten,1 Deborah de Kruijff,1 Aurora JAE van de Loo,1,2 Aletta D Kraneveld,1,2 Johan Garssen,1,3 Joris C Verster1,2,4 1Division of Pharmacology, Utrecht University, Utrecht, the Netherlands; 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; 3Nutricia Research, Utrecht, the Netherlands; 4Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia Background: Mental resilience can be seen as a trait that enables an individual to recover from stress and to face the next stressor with optimism. People with resilient traits are considered to have a better mental and physical health. However, there are limited data available assessing the relationship between resilient individuals and their perspective of their health and immune status. Therefore, this study was conducted to examine the relationship between mental resilience, perceived health, and perceived immune status. Methods: A total of 779 participants recruited at Utrecht University completed a questionnaire consisting of demographic characteristics, the brief resilience scale for the assessment of mental resilience, the immune function questionnaire (IFQ, and questions regarding their perceived health and immune status. Results: When correcting for gender, age, height, weight, smoker status, amount of cigarettes smoked per week, alcohol consumption status, amount of drinks consumed per week, drug use, and frequency of past year drug use, mental resilience was significantly correlated with perceived health (r=0.233, p=0.0001, perceived immune functioning (r=0.124, p=0.002, and IFQ score (r=−0.185, p=0.0001. Conclusion: A significant, albeit modest, relationship was found between mental resilience and perceived immune functioning and health. Keywords: mental resilience, immune functioning, health, vitality, quality of life

Management of noninfectious posterior uveitis with intravitreal drug therapy

Directory of Open Access Journals (Sweden)

Tan HY

2016-10-01

Full Text Available Hui Yi Tan,1 Aniruddha Agarwal,2 Cecilia S Lee,3 Jay Chhablani,4 Vishali Gupta,5 Manoj Khatri,6 Jayabalan Nirmal,7 Carlos Pavesio,8 Rupesh Agrawal1,7–9 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Department of Vitreoretina, Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 3Department of Ophthalmology, University of Washington, Seattle, WA, USA; 4Department of Vitreoretina, L V Prasad Eye Institute, Hyderabad, Telangana, 5Department of Retina and Uvea, Post Graduate Institute of Medical Education and Research, Chandigarh, 6Department of Retina, Rajan Eye Care Hospital, Chennai, Tamil Nadu, India; 7School of Material Science and Engineering, Nanyang Technological University, Singapore; 8Department of Medical Retina, Moorfields Eye Hospital, NHS Foundation Trust, London, UK; 9Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore Abstract: Uveitis is an important cause of vision loss worldwide due to its sight-threatening complications, especially cystoid macular edema, as well as choroidal neovascularization, macular ischemia, cataract, and glaucoma. Systemic corticosteroids are the mainstay of therapy for noninfectious posterior uveitis; however, various systemic side effects can occur. Intravitreal medication achieves a therapeutic level in the vitreous while minimizing systemic complications and is thus used as an exciting alternative. Corticosteroids, antivascular endothelial growth factors, immunomodulators such as methotrexate and sirolimus, and nonsteroidal anti-inflammatory drugs are currently available for intravitreal therapy. This article reviews the existing literature for efficacy and safety of these various options for intravitreal drug therapy for the management of noninfectious uveitis (mainly intermediate, posterior, and panuveitis. Keywords: intravitreal therapy, noninfectious uveitis, posterior uveitis

The reduction of the change of secondary ions yield in the thin SiON/Si system

International Nuclear Information System (INIS)

Sameshima, J.; Yamamoto, H.; Hasegawa, T.; Nishina, T.; Nishitani, T.; Yoshikawa, K.; Karen, A.

2006-01-01

For the analyses of gate insulating materials of thin silicon oxy-nitride (SiON) and dielectric films, SIMS is one of the available tool along with TEM and ESCA, etc. Especially, to investigate the distribution of dopant in the thin films, SIMS is appreciably effective in these techniques because of its depth profiling capability and high sensitivity. One of the problem occurring in this SIMS measurement is the change of secondary ion yield at the interface as well as in the layers with different chemical composition. To solve this problem, some groups have researched the phenomenon for SiO 2 /Si interface [W. Vandervorst, T. Janssens, R. Loo, M. Caymax, I. Peytier, R. Lindsay, J. Fruhauf, A. Bergmaier, G. Dollinger, Appl. Surf. Sci. 203-204 (2003) 371-376; S. Hayashi, K.Yanagihara, Appl. Surf. Sci. 203-204 (2003) 339-342; M. Barozzi, D. Giubertoni, M.Anderle, M. Bersani, Appl. Surf. Sci. 231-232 (2004) 632-635; T.H. Buyuklimanli, J.W. Marino, S.W. Novak, Appl. Surf. Sci. 231-232 (2004) 636-639]. In the present study, profiles of boron and matrix elements in the Si/SiON layers on Si substrate have been investigated. The sensitivity change of Si and B profiles in SiON layer become smaller by using oxygen flood than those without oxygen flood for both O 2 + and Cs + beam. At the range of 0-25 at.% of N composition, 11 B dosimetry in SiON layer implanted through amorphous Si depends on N composition. This trend could be caused by the sensitivity change of 11 B, or it indicates real 11 B concentration change in SiON lyaer. N areal density determined by Cs + SIMS with oxygen flooding also shows linear relationship with N composition estimated by XPS

The orientation, principles, priorities and aims of the state environmental policy

International Nuclear Information System (INIS)

1998-01-01

This chapter contains: (A) The orientation and priorities of state environmental policy of the government of the Slovak Republic which were approved 18 November 1993 by the resolution No 339. On the basis of the Strategy, principles and priorities of state environmental policy 70 short-terminable aims up to 1996, next 59 middle-terminable of aims up to years 2000 - 2010 and 33 general and partial long-terminable aims up to 2030 and longer were formulated. The Strategy is determined by next 5 branches oriented priorities: (1) air protection before pollutants and the global environmental safety; (2) organization of sufficiency of drinking water and decreasing of pollution of other waters under permissible limits; (3) soil protection before degeneration and organization of non-defected food-stuffs and other wares; (4) minimization of formation, use and good waste liquidate; (5) preservation of bio-diversity, preservation and rational use of natural reserves and optimization of place structure and use of the country. (B) The principles and priorities of state environmental policy determinate implementation and observance of then principles of the state environmental policy. (C) Total 162 aims of the Strategy of the state environmental policy and next followed programs, projects and measures of the environmental policy of the Slovak Republic can be grouped into 4 blocks: (1) the environmental policy in the protection of air, water and before of risk factors, in the nuclear safety and waste economy (environmental safety; (2) the environmental policy in protection of the nature and the country, protection and use of mineral surroundings, soils and forest;; (3) the environmental policy in the economy; (4) the environmental policy in the guidance, education, public information, organization, control and coordination of the ministration on the environment. These aims are grouped into 10 sectors. (D) The government of the Slovak republic has first National environmental

Swedish Military Bases of the Cold War The Making of a New Cultural Heritage

Directory of Open Access Journals (Sweden)

Per Strömberg

2010-12-01

Full Text Available The fall of the Berlin Wall and the dissolution of the Soviet Union completely transformed the military-political situation in the Nordic countries. The movement from invasion defence to input defence in Sweden has made many of the subter-ranean modern fortresses and permanent defence systems of the Cold War unnec-essary. The current problem is what the administration authorities will do with the superfluous military buildings: let them fall into decay, preserve or reuse them – and for what purpose? The aim of this article is to describe and analyze the cultural as well as spatial foundation of a new genre of heritage industry in Sweden – the cultural heritage of the Cold War – whose value is negotiated through a range of processes by the different stakeholders involved – emotional, social and cultural processes as well as legal and economic processes. The subterranean fortresses of Hemsö and Aspö are used as empirical case studies in the article. They both describe the making of a cultural heritage and illustrate the problems related to the ambitions of convert-ing cultural heritage into tourist attractions. One of the conclusions is that the previous making of the industrial cultural heritage in the 1980s and 1990s has many things in common with the one of the Cold War. The “post-military” landscape of bunkers and rusting barbed wires is regarded with the same romanticism and with similar preservation ideologies and economic interests as the post-industrial landscape was earlier. Similar negotiation issues appear, and these negotiations are carried out by similar stakeholders. The difference is that the military culture heritage of the Cold War was developed through a deeply centralized selection process directed by administration authori-ties, but was also influenced by certain persuasion campaigns and preservation actions made by local stakeholders such as retired officers and municipality ad-ministrations.