Tertiary structure mapping of the pri-miRNA miR-17~92.
Chaulk, Steven G; Fahlman, Richard P
2014-01-01
The understanding of RNA in regulating gene expression has exploded over the past 15 years. MicroRNAs (miRNAs) have vastly expanded the role of RNA in gene regulation beyond spliceosomal, ribosomal, and messenger RNAs. Approximately one half of miRNAs are polycistronic, where two or more miRNAs are encoded on a single pri-miRNA transcript, termed a miRNA cluster. The six miRNAs of the miR-17~92 cluster are contained within a ~800 nucleotide region within intron 3 of the cl13orf25 ~7 kb pri-miRNA transcript. We recently reported on the tertiary structured domain of miR-17~92 and its role in modulating miRNA biogenesis. The key finding was that the cluster structure explained the differential processing of the miRNA hairpins by Drosha. This work demonstrated the need to consider pri-miRNA tertiary structure in miRNA biogenesis. Since biochemical structure probing is typically performed on relatively short RNAs (≤200 nucleotides), we had to adapt these methodologies for application on large RNAs (~800 nucleotide miR-17~92 pri-miRNA). We present here our adaptation of a protection footprinting method using ribonucleases to probe the structure of the ~800 nucleotide miR-17~92 pri-miRNA. We outline the technical difficulties involved in probing large RNAs and data visualization using denaturing polyacrylamide gel electrophoresis and how we adapted the existing approaches to probe large RNAs. The methodology outlined here is generally applicable to large RNAs including long noncoding RNAs (lncRNA).
miR-17-92基因簇研究进展%Research Progress of miR-17-92 Cluster
于宇; 张淑兰
2014-01-01
MicroRNAs (miRNA) are a class of highly conserved small,single-stranded non-coding RNAs that regulate target genes expression by fully or partially complementary principle binds to target genes 3′UTRs or direct shear target genes mRNA. miR-17-92 cluster is located on human chromosome 13q31.3,which encodes miR-17,miR-18,miR-19a,miR-20, miR-19b and miR-92. miR-17-92 cluster controls 30 kinds of target genes ,which involve in cancer development. The paper reviews the structure and function and the roles of miR-17-92 cluster in gynaecology and other tumors occurrence and development.%微小RNA（microRNA，miRNA）是一类内源性的非编码的高度保守的单链小分子RNA，通过完全和（或）部分互补的原则结合到靶基因3′UTRs或者直接剪切靶基因mRNA，以降解或抑制mRNA翻译的方式调控靶基因的表达。 miR-17-92基因簇位于人染色体13q31.3处，可产生miR-17，miR-18，miR-19a，miR-20，miR-19b和miR-92等6个成熟的miRNA。miR-17-92基因簇通过调控30多种靶基因参与肿瘤的发生发展。综述miR-17-92基因簇的结构和功能，及其在妇科及其他肿瘤发生发展中的作用。
miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression
Junghee Jin
2016-08-01
Full Text Available Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs, contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here, we show that altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact on neurogenesis and anxiety- and depression-related behaviors in mice. miR-17-92 deletion in adult neural progenitors decreases neurogenesis in the dentate gyrus, while its overexpression increases neurogenesis. miR-17-92 affects neurogenesis by regulating genes in the glucocorticoid pathway, especially serum- and glucocorticoid-inducible protein kinase-1 (Sgk1. miR-17-92 knockout mice show anxiety- and depression-like behaviors, whereas miR-17-92 overexpressing mice exhibit anxiolytic and antidepression-like behaviors. Furthermore, we show that miR-17-92 expression in the adult mouse hippocampus responds to chronic stress, and miR-17-92 rescues proliferation defects induced by corticosterone in hippocampal neural progenitors. Our study uncovers a crucial role for miR-17-92 in adult neural progenitors through regulation of neurogenesis and anxiety- and depression-like behaviors.
Mapping and expression studies of the mir17-92 cluster on pig chromosome 11
Sawera, Milena; Gorodkin, Jan; Cirera, Susanna;
2005-01-01
We have identified the first porcine microRNA (miRNA) cluster (the mir17-92 cluster) and localized it to the q-arm of pig Chromosome 11. The miRNA cluster was found by sequence similarity search with human miRNA sequences against the pig genomic data generated within the Sino-Danish pig genome...... project. The resulting data contained three complete and two incomplete miRNA precursors of seven miRNAs from the human mir17-92 cluster. Because there is a 100% sequence identity between the four pig miRNAs and the corresponding human miRNAs, the sequences of three unavailable pig miRNAs were derived...... from the human data. The expression profiles of seven studied miRNAs were analyzed by hybridization to Northern blots containing five porcine tissues: cerebellum, cortex, hippocampus, kidney, and liver. In order to determine the localization of the mir17-92 cluster in the pig genome, we mapped...
Differential Sensitivity of Target Genes to Translational Repression by miR-17~92
Jin, Hyun Yong; Oda, Hiroyo; Chen, Pengda; Kang, Seung Goo; Valentine, Elizabeth; Liao, Lujian; Zhang, Yaoyang; Gonzalez-Martin, Alicia; Shepherd, Jovan; Head, Steven R.; Kim, Pyeung-Hyeun; Fu, Guo; Liu, Wen-Hsien; Han, Jiahuai
2017-01-01
MicroRNAs (miRNAs) are thought to exert their functions by modulating the expression of hundreds of target genes and each to a small degree, but it remains unclear how small changes in hundreds of target genes are translated into the specific function of a miRNA. Here, we conducted an integrated analysis of transcriptome and translatome of primary B cells from mutant mice expressing miR-17~92 at three different levels to address this issue. We found that target genes exhibit differential sensitivity to miRNA suppression and that only a small fraction of target genes are actually suppressed by a given concentration of miRNA under physiological conditions. Transgenic expression and deletion of the same miRNA gene regulate largely distinct sets of target genes. miR-17~92 controls target gene expression mainly through translational repression and 5’UTR plays an important role in regulating target gene sensitivity to miRNA suppression. These findings provide molecular insights into a model in which miRNAs exert their specific functions through a small number of key target genes. PMID:28241004
Rui Xiang
2012-02-01
Full Text Available MicroRNAs (miRNAs have gradually been recognized as regulators of embryonic development; however, relatively few miRNAs have been identified that regulate cardiac development. A series of recent papers have established an essential role for the miRNA-17-92 (miR-17-92 cluster of miRNAs in the development of the heart. Previous research has shown that the Friend of Gata-2 (FOG-2 is critical for cardiac development. To investigate the possibility that the miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation in mouse embryonic cardiomyocytes we initially used bioinformatics to analyze 3’ untranslated regions (3’UTR of FOG-2 to predict the potential of miR-17-92 to target it. We used luciferase assays to demonstrate that miR-17-5p and miR-20a of miR-17-92 interact with the predicted target sites in the 3’UTR of FOG-2. Furthermore, RT-PCR and Western blot were used to demonstrate the post-transcriptional regulation of FOG-2 by miR-17-92 in embryonic cardiomyocytes from E12.5-day pregnant C57BL/6J mice. Finally, EdU cell assays together with the FOG-2 rescue strategy were employed to evaluate the effect of proliferation on embryonic cardiomyocytes. We first found that the miR-17-5p and miR-20a of miR-17-92 directly target the 3’UTR of FOG-2 and post-transcriptionally repress the expression of FOG-2. Moreover, our findings demonstrated that over-expression of miR-17-92 may inhibit cell proliferation via post-transcriptional repression of FOG-2 in embryonic cardiomyocytes. These results indicate that the miR-17-92 cluster regulates the expression of FOG-2 protein and suggest that the miR-17-92 cluster might play an important role in heart development.
Identification and analysis of ZFPM2 as a target gene of miR-17-92 cluster in chicken.
Zhang, Xiao-fei; Song, He; Liu, Jing; Zhang, Wen-jian; Yan, Xiao-hong; Li, Hui; Wang, Ning
2017-04-20
The miR-17-92 cluster plays important roles in a variety of physiological and pathological processes in mammals. Previously, we showed that miR-17-92 cluster promotes chicken preadipocyte proliferation; however, the mechanism for its action is unknown. In order to explore the mechanism by which miR-17-92 cluster promotes chicken preadipocyte proliferation, CCK8 proliferation assay was performed to determine the effect of ZFPM2 knockdown on chicken preadipocyte proliferation. The results showed that ZFPM2 knockdown significantly promoted chicken preadipocyte proliferation (Panalysis showed that there were two potential miRNA binding sites for the four individual members of miR-17-92 cluster in the ZFPM2 3'UTR, one for miR-17-5p and miR-20a and the other for miR-19a and miR-19b. To test whether ZFPM2 is a target for the miR-17-92 cluster, the ZFPM2 3'UTR reporter (psi-CHECK2-ZFPM2-3'UTR-WT) and its mutant reporter (psi-CHECK2-ZFPM2-3'UTR-MUT) were constructed. Reporter assays showed that overexpression of miR-17-92 cluster significantly inhibited the luciferase reporter activity of psi-CHECK2-ZFPM2-3'UTR-WT (Panalysis showed that miR-17-5p, miR-20a and miR-19a inhibitors significantly elevated the endogenous ZFPM2 mRNA expression (Pcluster promotes chicken preadipocyte proliferation at least in part by targeting ZFPM2 and inhibiting its expression.
Samer Kayali
Full Text Available Clonal erythroleukemia developing in susceptible mice infected by Friend virus complex are associated with highly recurrent proviral insertions at one of three loci called Spi-1, Fli-1 or Fli-3, leading to deregulated expression of oncogenic Spi-1 or Fli-1 transcription factors or miR-17-92 miRNA cluster, respectively. Deregulated expression of each of these three oncogenes has been independently shown to contribute to cell proliferation of erythroleukemic clones. Previous studies showed a close relationship between Spi-1 and Fli-1, which belong to the same ETS family, Spi-1 activating fli-1 gene, and both Spi-1 and Fli-1 activating multiple common target genes involved in ribosome biogenesis. In this study, we demonstrated that Spi-1 and Fli-1 are also involved in direct miR-17-92 transcriptional activation through their binding to a conserved ETS binding site in its promoter. Moreover, we demonstrated that physiological re-expression of exogenous miR-17 and miR-20a are able to partially rescue the proliferation loss induced by Fli-1 knock-down and identified HBP1 as a target of these miRNA in erythroleukemic cells. These results establish that three of the most recurrently activated oncogenes in Friend erythroleukemia are actually involved in a same oncogenic network controlling cell proliferation. The putative contribution of a similar ETS-miR-17-92 network module in other normal or pathological proliferative contexts is discussed.
Kayali, Samer; Giraud, Guillaume; Morlé, François; Guyot, Boris
2012-01-01
Clonal erythroleukemia developing in susceptible mice infected by Friend virus complex are associated with highly recurrent proviral insertions at one of three loci called Spi-1, Fli-1 or Fli-3, leading to deregulated expression of oncogenic Spi-1 or Fli-1 transcription factors or miR-17-92 miRNA cluster, respectively. Deregulated expression of each of these three oncogenes has been independently shown to contribute to cell proliferation of erythroleukemic clones. Previous studies showed a close relationship between Spi-1 and Fli-1, which belong to the same ETS family, Spi-1 activating fli-1 gene, and both Spi-1 and Fli-1 activating multiple common target genes involved in ribosome biogenesis. In this study, we demonstrated that Spi-1 and Fli-1 are also involved in direct miR-17-92 transcriptional activation through their binding to a conserved ETS binding site in its promoter. Moreover, we demonstrated that physiological re-expression of exogenous miR-17 and miR-20a are able to partially rescue the proliferation loss induced by Fli-1 knock-down and identified HBP1 as a target of these miRNA in erythroleukemic cells. These results establish that three of the most recurrently activated oncogenes in Friend erythroleukemia are actually involved in a same oncogenic network controlling cell proliferation. The putative contribution of a similar ETS-miR-17-92 network module in other normal or pathological proliferative contexts is discussed.
Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer.
Yu, Ge; Tang, Jian-Qiang; Tian, Mao-Lin; Li, Hui; Wang, Xin; Wu, Tao; Zhu, Jing; Huang, Shan-Jun; Wan, Yuan-Lian
2012-09-01
MicroRNAs have been shown to offer great potential in both the diagnosis and prognosis of cancer. Despite the well-established role of the miR-17-92 in cancer formation and progression, the contribution of each individual miRNA remains to be characterized. Thus, we investigated whether deregulation of the miR-17-92 associated with colon cancer prognosis. Expression levels of the miR-17-92 cluster and its paralogs were determined in 48 colon tumor and 48 paired normal tissues by real-time qRT-PCR. Associations with miRNA expression, age, sex, TNM staging, and survival prognosis were evaluated. MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P = 0.007) and TNM staging (HR 8.87; P = 0.002) were significantly associated with a risk of death. The miR-17-92 cluster and its paralogs were significantly elevated in patients with colon cancer, and heightened expression of miR-17 was associated with poor survival. Moreover, miR-17 and TNM staging were both identified as significant, but independent, prognostic biomarkers in colon cancer. Copyright © 2011 Wiley Periodicals, Inc.
Li, Yulin
2014-08-01
The MYC oncogene regulates gene expression through multiple mechanisms, and its overexpression culminates in tumorigenesis. MYC inactivation reverses turmorigenesis through the loss of distinguishing features of cancer, including autonomous proliferation and survival. Here we report that MYC via miR-17-92 maintains a neoplastic state through the suppression of chromatin regulatory genes Sin3b, Hbp1, Suv420h1, and Btg1, as well as the apoptosis regulator Bim. The enforced expression of miR-17-92 prevents MYC suppression from inducing proliferative arrest, senescence, and apoptosis and abrogates sustained tumor regression. Knockdown of the five miR-17-92 target genes blocks senescence and apoptosis while it modestly delays proliferative arrest, thus partially recapitulating miR-17-92 function. We conclude that MYC, via miR-17-92, maintains a neoplastic state by suppressing specific target genes.
Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis.
Chaulk, Steven G; Thede, Gina L; Kent, Oliver A; Xu, Zhizhong; Gesner, Emily M; Veldhoen, Richard A; Khanna, Suneil K; Goping, Ing Swie; MacMillan, Andrew M; Mendell, Joshua T; Young, Howard S; Fahlman, Richard P; Glover, J N Mark
2011-01-01
MicroRNAs (miRNAs) regulate gene expression in a variety of biological pathways such as development and tumourigenesis. miRNAs are initially expressed as long primary transcripts (pri-miRNAs) that undergo sequential processing by Drosha and then Dicer to yield mature miRNAs. miR-17~92 is a miRNA cluster that encodes 6 miRNAs and while it is essential for development it also has reported oncogenic activity. To date, the role of RNA structure in miRNA biogenesis has only been considered in terms of the secondary structural elements required for processing of pri-miRNAs by Drosha. Here we report that the miR-17~92 cluster has a compact globular tertiary structure where miRNAs internalized within the core of the folded structure are processed less efficiently than miRNAs on the surface of the structure. Increased miR-92 expression resulting from disruption of the compact miR-17~92 structure results in increased repression of integrin α5 mRNA, a known target of miR-92a. In summary, we describe the first example of pri-miRNA structure modulating differential expression of constituent miRNAs.
Mogilyansky, E; Rigoutsos, I
2013-12-01
The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.
Jesper A. B. Strickertsson
2014-08-01
Full Text Available Chronic inflammation due to bacterial overgrowth of the stomach predisposes to the development of gastric cancer and is also associated with high levels of reactive oxygen species (ROS. In recent years increasing attention has been drawn to microRNAs (miRNAs due to their role in the pathogenesis of many human diseases including gastric cancer. Here we studied the impact of infection by the gram-positive bacteria Enterococcus faecalis (E. faecalis on global miRNA expression as well as the effect of ROS on selected miRNAs. Human gastric adenocarcinoma cell line MKN74 was infected with living E. faecalis for 24 h or for 5 days or with E. faecalis lysate for 5 days. The miRNA expression was examined by microarray analysis using Affymetrix GeneChip miRNA Arrays. To test the effect of ROS, MKN74 cells were treated with 100 mM tert-Butyl hydroperoxide (TBHP. Following 5 days of E. faecalis infection we found 91 differentially expressed miRNAs in response to living bacteria and 2 miRNAs responded to E. faecalis lysate. We verified the down-regulation of the miR-17-92 and miR-106-363 clusters and of other miRNAs involved in the oxidative stress-response by qRT-PCR. We conclude that only infection by living E. faecalis bacteria caused a significant global response in miRNA expression in the MKN74 cell culture. E. faecalis infection as well as ROS stimulation down-regulated the expression of the miR-17-92 cluster. We believe that these changes could reflect a general response of gastric epithelial cells to bacterial infections.
Zhang, Kaiping; Zhang, Li; Zhang, Meng; Zhang, Yin; Fan, Dengxin; Jiang, Jiabin; Ye, Liqin; Fang, Xiang; Chen, Xianguo; Fan, Song; Chao, Min; Liang, Chaozhao
2017-08-21
The prognostic value of miR-17-92 cluster high-expression in various tumors remains controversial. Therefore, we conducted this meta-analysis by searching literatures in PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure to identify eligible studies. Eventually, we analyzed 36 articles that examined 17 tumor types from 4965 patients. Consequently, high-expression of miR-17-92 cluster in various tumors was associated with unfavorable overall survival in both univariate (HR = 2.05, 95%CI: 1.58-2.65, Pcluster component, sample source and size. Additionally, high-expression of miR-17-92 cluster was linked with poor disease-free survival (Univariate: HR = 1.96, 95%CI: 1.55-2.48, Pcluster high-expression was detected with recurrence or relapse-free survival. In summary, this meta-analysis towards high-expression of miR-17-92 cluster has indicated poor prognosis of various cancers. Notably, future studies comprising large cohort size from multicenter are required to confirm our conclusions.
Hong Seok Choi
Full Text Available KSHV is a DNA tumor virus that causes Kaposi's sarcoma. Upon KSHV infection, only a limited number of latent genes are expressed. We know that KSHV infection regulates host gene expression, and hypothesized that latent genes also modulate the expression of host miRNAs. Aberrant miRNA expression contributes to the development of many types of cancer. Array-based miRNA profiling revealed that all six miRNAs of the oncogenic miR-17-92 cluster are up-regulated in KSHV infected endothelial cells. Among candidate KSHV latent genes, we found that vFLIP and vCyclin were shown to activate the miR-17-92 promoter, using luciferase assay and western blot analysis. The miR-17-92 cluster was previously shown to target TGF-β signaling. We demonstrate that vFLIP and vCyclin induce the expression of the miR-17-92 cluster to strongly inhibit the TGF-β signaling pathway by down-regulating SMAD2. Moreover, TGF-β activity and SMAD2 expression were fully restored when antagomirs (inhibitors of miR-17-92 cluster were transfected into cells expressing either vFLIP or vCyclin. In addition, we utilized viral genetics to produce vFLIP or vCyclin knock-out viruses, and studied the effects in infected TIVE cells. Infection with wildtype KSHV abolished expression of SMAD2 protein in these endothelial cells. While single-knockout mutants still showed a marked reduction in SMAD2 expression, TIVE cells infected by a double-knockout mutant virus were fully restored for SMAD2 expression, compared to non-infected TIVE cells. Expression of either vFLIP or vCycIin was sufficient to downregulate SMAD2. In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS.
Choi, Hong Seok; Jain, Vaibhav; Krueger, Brian; Marshall, Vickie; Kim, Chang Hee; Shisler, Joanna L.; Whitby, Denise; Renne, Rolf
2015-01-01
KSHV is a DNA tumor virus that causes Kaposi’s sarcoma. Upon KSHV infection, only a limited number of latent genes are expressed. We know that KSHV infection regulates host gene expression, and hypothesized that latent genes also modulate the expression of host miRNAs. Aberrant miRNA expression contributes to the development of many types of cancer. Array-based miRNA profiling revealed that all six miRNAs of the oncogenic miR-17-92 cluster are up-regulated in KSHV infected endothelial cells. Among candidate KSHV latent genes, we found that vFLIP and vCyclin were shown to activate the miR-17-92 promoter, using luciferase assay and western blot analysis. The miR-17-92 cluster was previously shown to target TGF-β signaling. We demonstrate that vFLIP and vCyclin induce the expression of the miR-17-92 cluster to strongly inhibit the TGF-β signaling pathway by down-regulating SMAD2. Moreover, TGF-β activity and SMAD2 expression were fully restored when antagomirs (inhibitors) of miR-17-92 cluster were transfected into cells expressing either vFLIP or vCyclin. In addition, we utilized viral genetics to produce vFLIP or vCyclin knock-out viruses, and studied the effects in infected TIVE cells. Infection with wildtype KSHV abolished expression of SMAD2 protein in these endothelial cells. While single-knockout mutants still showed a marked reduction in SMAD2 expression, TIVE cells infected by a double-knockout mutant virus were fully restored for SMAD2 expression, compared to non-infected TIVE cells. Expression of either vFLIP or vCycIin was sufficient to downregulate SMAD2. In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. PMID:26545119
Choi, Hong Seok; Jain, Vaibhav; Krueger, Brian; Marshall, Vickie; Kim, Chang Hee; Shisler, Joanna L; Whitby, Denise; Renne, Rolf
2015-01-01
KSHV is a DNA tumor virus that causes Kaposi's sarcoma. Upon KSHV infection, only a limited number of latent genes are expressed. We know that KSHV infection regulates host gene expression, and hypothesized that latent genes also modulate the expression of host miRNAs. Aberrant miRNA expression contributes to the development of many types of cancer. Array-based miRNA profiling revealed that all six miRNAs of the oncogenic miR-17-92 cluster are up-regulated in KSHV infected endothelial cells. Among candidate KSHV latent genes, we found that vFLIP and vCyclin were shown to activate the miR-17-92 promoter, using luciferase assay and western blot analysis. The miR-17-92 cluster was previously shown to target TGF-β signaling. We demonstrate that vFLIP and vCyclin induce the expression of the miR-17-92 cluster to strongly inhibit the TGF-β signaling pathway by down-regulating SMAD2. Moreover, TGF-β activity and SMAD2 expression were fully restored when antagomirs (inhibitors) of miR-17-92 cluster were transfected into cells expressing either vFLIP or vCyclin. In addition, we utilized viral genetics to produce vFLIP or vCyclin knock-out viruses, and studied the effects in infected TIVE cells. Infection with wildtype KSHV abolished expression of SMAD2 protein in these endothelial cells. While single-knockout mutants still showed a marked reduction in SMAD2 expression, TIVE cells infected by a double-knockout mutant virus were fully restored for SMAD2 expression, compared to non-infected TIVE cells. Expression of either vFLIP or vCycIin was sufficient to downregulate SMAD2. In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS.
Shan Bian
2013-05-01
Full Text Available During development of the embryonic neocortex, tightly regulated expansion of neural stem cells (NSCs and their transition to intermediate progenitors (IPs are critical for normal cortical formation and function. Molecular mechanisms that regulate NSC expansion and transition remain unclear. Here, we demonstrate that the microRNA (miRNA miR-17-92 cluster is required for maintaining proper populations of cortical radial glial cells (RGCs and IPs through repression of Pten and Tbr2 protein. Knockout of miR-17-92 and its paralogs specifically in the developing neocortex restricts NSC proliferation, suppresses RGC expansion, and promotes transition of RGCs to IPs. Moreover, Pten and Tbr2 protectors specifically block silencing activities of endogenous miR-17-92 and control proper numbers of RGCs and IPs in vivo. Our results demonstrate a critical role for miRNAs in promoting NSC proliferation and modulating the cell-fate decision of generating distinct neural progenitors in the developing neocortex.
Bian, Shan; Hong, Janet; Li, Qingsong; Schebelle, Laura; Pollock, Andrew; Knauss, Jennifer L; Garg, Vidur; Sun, Tao
2013-05-30
During development of the embryonic neocortex, tightly regulated expansion of neural stem cells (NSCs) and their transition to intermediate progenitors (IPs) are critical for normal cortical formation and function. Molecular mechanisms that regulate NSC expansion and transition remain unclear. Here, we demonstrate that the microRNA (miRNA) miR-17-92 cluster is required for maintaining proper populations of cortical radial glial cells (RGCs) and IPs through repression of Pten and Tbr2 protein. Knockout of miR-17-92 and its paralogs specifically in the developing neocortex restricts NSC proliferation, suppresses RGC expansion, and promotes transition of RGCs to IPs. Moreover, Pten and Tbr2 protectors specifically block silencing activities of endogenous miR-17-92 and control proper numbers of RGCs and IPs in vivo. Our results demonstrate a critical role for miRNAs in promoting NSC proliferation and modulating the cell-fate decision of generating distinct neural progenitors in the developing neocortex.
Lijian Yang
Full Text Available Based on interactions among transcription factors, oncogenes, tumor suppressors and microRNAs, a Boolean model of cancer network regulated by miR-17-92 cluster is constructed, and the network is associated with the control of G1/S transition in the mammalian cell cycle. The robustness properties of this regulatory network are investigated by virtue of the Boolean network theory. It is found that, during G1/S transition in the cell cycle process, the regulatory networks are robustly constructed, and the robustness property is largely preserved with respect to small perturbations to the network. By using the unique process-based approach, the structure of this network is analyzed. It is shown that the network can be decomposed into a backbone motif which provides the main biological functions, and a remaining motif which makes the regulatory system more stable. The critical role of miR-17-92 in suppressing the G1/S cell cycle checkpoint and increasing the uncontrolled proliferation of the cancer cells by targeting a genetic network of interacting proteins is displayed with our model.
Hu, Shien; Liu, Lan; Chang, Eugene B; Wang, Jian-Ying; Raufman, Jean-Pierre
2015-10-13
Compromised colonic butyrate production resulting from low dietary fiber or altered gut microbiota may promote colon neoplasia. Previous reports indicate these actions are mediated in part by altered levels of miRNAs, including suppressed expression of the oncogenic miR-17-92a cluster. Here, we sought to identify the mechanisms underlying these effects of butyrate in colon cancer. miR-92a levels were measured in archived human colon cancer and adjacent normal colon specimens by microarray and quantitative RT-PCR (qPCR). The effects of butyrate and other histone deacetylase inhibitors (suberoylanilide hydroxamic acid (SAHA) and valproic acid) on primary (pri-miR17-92a), precursor and mature miR-92a were analyzed in HCT-116 and HT-29 human colon cancer cells using qPCR. The effects of butyrate, SAHA and valproic acid on protein levels of c-Myc, Drosha and p57 were measured in HCT-116 cells using immunoblotting. Regulation of C13orf25 promoter activity by butyrate was analyzed by luciferase reporter assay using modified pGL3 constructs containing a wild-type or mutated c-Myc binding site. Expression of c-Myc was modulated using siRNA or adenovirus vectors. p57 mRNA and protein were measured before and after transfection with miR-92a-mimic molecules. Following butyrate treatment and miR-92a-mimic transfection, apoptosis was analyzed by TUNEL staining and caspase-3 immunoblotting. Microarray, confirmed by qPCR, revealed a seven-fold increase in miR-92a levels in sporadic human colon cancer tissue compared to adjacent normal colon. Treating human colon cancer cells with butyrate reduced the levels of pri-miR17-92a, precursor and mature miR-92a, as well as c-Myc. SAHA and valproic acid had similar effects. Mutation of the c-Myc binding site diminished butyrate's inhibitory effects on C13orf25 promoter activity. Silencing c-Myc expression reduced miR-92a levels. c-Myc over-expression neutralized butyrate-induced attenuation of pri-miR17-92a. Exogenous miR-92a inhibited butyrate-induced p57 expression and reversed the beneficial actions of butyrate on colon cancer cell proliferation and apoptosis. Our findings identify a novel cellular mechanism whereby butyrate inhibits miR-92a transcription by reducing c-Myc, thus augmenting p57 levels. These actions diminish colon cancer cell proliferation and stimulate apoptosis. This newly described regulation of oncogenic miRNA biogenesis expands our understanding of colon cancer cell biology and identifies novel therapeutic targets.
Equilibrium models of coronal loops that involve curvature and buoyancy
Hindman, Bradley W
2013-01-01
We construct magnetostatic models of coronal loops in which the thermodynamics of the loop is fully consistent with the shape and geometry of the loop. This is achieved by treating the loop as a thin, compact, magnetic fibril that is a small departure from a force-free state. The density along the loop is related to the loop's curvature by requiring that the Lorentz force arising from this deviation is balanced by buoyancy. This equilibrium, coupled with hydrostatic balance and the ideal gas law, then connects the temperature of the loop with the curvature of the loop without resorting to a detailed treatment of heating and cooling. We present two example solutions: one with a spatially invariant magnetic Bond number (the dimensionless ratio of buoyancy to Lorentz forces) and the other with a constant radius of curvature of the loop's axis. We find that the density and temperature profiles are quite sensitive to curvature variations along the loop, even for loops with similar aspect ratios.
Equilibrium Models of Coronal Loops That Involve Curvature and Buoyancy
Hindman, Bradley W.; Jain, Rekha
2013-12-01
We construct magnetostatic models of coronal loops in which the thermodynamics of the loop is fully consistent with the shape and geometry of the loop. This is achieved by treating the loop as a thin, compact, magnetic fibril that is a small departure from a force-free state. The density along the loop is related to the loop's curvature by requiring that the Lorentz force arising from this deviation is balanced by buoyancy. This equilibrium, coupled with hydrostatic balance and the ideal gas law, then connects the temperature of the loop with the curvature of the loop without resorting to a detailed treatment of heating and cooling. We present two example solutions: one with a spatially invariant magnetic Bond number (the dimensionless ratio of buoyancy to Lorentz forces) and the other with a constant radius of the curvature of the loop's axis. We find that the density and temperature profiles are quite sensitive to curvature variations along the loop, even for loops with similar aspect ratios.
Resilience of Urban Smart Grids Involving Multiple Control Loops
Madsen, Jacob Theilgaard; Pillai, Jayakrishnan Radhakrishna; Schwefel, Hans-Peter
2016-01-01
Intelligent control of energy distribution grids is implemented via a hierarchy of control loops with different input values and different control targets, which also work on different time-scales. This control is enabled by a bi-directional communication flow, which can be interrupted due to ICT...... attacks. It is therefore necessary to analyze and understand the emergent behavior resulting from the interplay of the different control loops and how this behavior may change under different communication scenarios. The simulation scenario considered in this paper is a medium and low voltage grid...... in island mode with a limited grid buffer capacity subjected to ICT attacks. First the interplay of four different control loops that all react to time-varying prices is analyzed. A co-simulation framework is applied to specifically investigate the sensitivity of the emergent grid behavior to extreme...
Resilience of Urban Smart Grids Involving Multiple Control Loops
Madsen, Jacob Theilgaard; Pillai, Jayakrishnan Radhakrishna; Schwefel, Hans-Peter
2016-01-01
Intelligent control of energy distribution grids is implemented via a hierarchy of control loops with different input values and different control targets, which also work on different time-scales. This control is enabled by a bi-directional communication flow, which can be interrupted due to ICT...
Closed-loop response properties of a visual interneuron involved in fly optomotor control
Naveed eEjaz
2013-03-01
Full Text Available Due to methodological limitations neural function is mostly studied under open-loop conditions. Normally, however, nervous systems operate in closed-loop where sensory input is processed to generate behavioural outputs, which again change the sensory input. Here, we investigate the closed-loop responses of an identified visual interneuron, the blowfly H1-cell, that is part of a neural circuit involved in optomotor flight and gaze control. Those behaviours may be triggered by attitude changes during flight in turbulent air. The fly analyses the resulting retinal image shifts and performs compensatory body and head rotations to regain its default attitude. We developed a fly-robot interface to study H1-cell responses in a 1 degree-of-freedom image stabilization task. Image shifts, induced by externally forced rotations, modulate the cell’s spike rate that controls counter rotations of a mobile robot to minimize relative motion between the robot and its visual surroundings. A feedback controller closed the loop between neural activity and the rotation of the robot. Under these conditions we found the following H1-cell response properties: (i the peak spike rate decreases when the mean image velocity is increased, (ii the relationship between spike rate and image velocity depends on the standard deviation of the image velocities suggesting adaptive scaling of the cell’s signalling range, and (iii the cell’s gain decreases linearly with increasing image accelerations.Our results reveal a remarkable qualitative similarity between the response dynamics of the H1-cell under closed-loop conditions with those obtained in previous open-loop experiments. Finally, we show that the adaptive scaling of the H1-cell’s responses, while maximizing information on image velocity, decreases the cell’s sensitivity to image accelerations. Understanding such trade-offs in biological vision systems may advance the design of smart vision sensors for autonomous
Closed-loop response properties of a visual interneuron involved in fly optomotor control.
Ejaz, Naveed; Krapp, Holger G; Tanaka, Reiko J
2013-01-01
Due to methodological limitations neural function is mostly studied under open-loop conditions. Normally, however, nervous systems operate in closed-loop where sensory input is processed to generate behavioral outputs, which again change the sensory input. Here, we investigate the closed-loop responses of an identified visual interneuron, the blowfly H1-cell, that is part of a neural circuit involved in optomotor flight and gaze control. Those behaviors may be triggered by attitude changes during flight in turbulent air. The fly analyses the resulting retinal image shifts and performs compensatory body and head rotations to regain its default attitude. We developed a fly robot interface to study H1-cell responses in a 1 degree-of-freedom image stabilization task. Image shifts, induced by externally forced rotations, modulate the cell's spike rate that controls counter rotations of a mobile robot to minimize relative motion between the robot and its visual surroundings. A feedback controller closed the loop between neural activity and the rotation of the robot. Under these conditions we found the following H1-cell response properties: (i) the peak spike rate decreases when the mean image velocity is increased, (ii) the relationship between spike rate and image velocity depends on the standard deviation of the image velocities suggesting adaptive scaling of the cell's signaling range, and (iii) the cell's gain decreases linearly with increasing image accelerations. Our results reveal a remarkable qualitative similarity between the response dynamics of the H1-cell under closed-loop conditions with those obtained in previous open-loop experiments. Finally, we show that the adaptive scaling of the H1-cell's responses, while maximizing information on image velocity, decreases the cell's sensitivity to image accelerations. Understanding such trade-offs in biological vision systems may advance the design of smart vision sensors for autonomous robots.
Konstantinos Blouhos
2013-08-01
Full Text Available As the literature on afferent loop obstruction (ALO after pancreaticoduodenectomy (PD is very limited, standardized rules for its management do not exist. Herein, we report the case of a 65-year-old male patient with chronic ALO who had undergone PD with single Roux-en-Y limb reconstruction and adjuvant chemoradiation therapy for pancreatic head adenocarcinoma 2 years earlier. The patient was brought to the operating room with the diagnosis of radiation enteritis of the afferent loop with segmental involvement and concurrent hepaticojejunostomy (HJ and pancreaticojejunostomy (PJ stricture. Complete mobilization of the afferent loop, removal of the affected segment and reconstruction were performed. Reconstruction of the afferent loop was a one-way option for the surgeons because the Roux-en-Y reconstruction limited endoscopic access to the afferent loop, and the segmental radiation injury of the afferent loop ruled out bypass surgery. However, mobilization of the affected segment through a field of dense adhesions and revision of the HJ and PJ were technically demanding.
Computation of NLO Processes Involving Heavy Quarks Using Loop-Tree Duality
Driencourt-Mangin, Felix
2016-01-01
We present a new method to compute higher-order corrections to physical cross-sections, at Next-to-Leading Order and beyond. This method, based on the Loop Tree Duality, leads to locally integrable expressions in four dimensions. By introducing a physically motivated momentum mapping between the momenta involved in the real and the virtual contributions, infrared singularities naturally cancel at integrand level, without the need to introduce subtraction counter-terms. Ultraviolet singularities are dealt with by using dual representations of suitable counter-terms, with some subtleties regarding the self-energy contributions. As an example, we apply this method to compute the $1\\to2$ decay rate in the context of a scalar toy model with massive particles.
Strickertsson, Jesper A B; Rasmussen, Lene Juel; Friis-Hansen, Lennart
2014-01-01
Chronic inflammation due to bacterial overgrowth of the stomach predisposes to the development of gastric cancer and is also associated with high levels of reactive oxygen species (ROS). In recent years increasing attention has been drawn to microRNAs (miRNAs) due to their role in the pathogenesis...
Pérez, Ernesto; Lindblad, Jillian L; Bergmann, Andreas
2017-08-30
Apoptosis and its molecular mediators, the caspases, have long been regarded as tumor suppressors and one hallmark of cancer is 'Evading Apoptosis'. However, recent work has suggested that apoptotic caspases can also promote proliferation and tumor growth under certain conditions. How caspases promote proliferation and how cells are protected from the potentially harmful action of apoptotic caspases is largely unknown. Here, we show that although caspases are activated in a well-studied neoplastic tumor model in Drosophila, oncogenic mutations of the proto-oncogene Ras (Ras(V12)) maintain tumorous cells in an 'undead'-like condition and transform caspases from tumor suppressors into tumor promotors. Instead of killing cells, caspases now promote the generation of intra- and extracellular reactive oxygen species (ROS). One function of the ROS is the recruitment and activation of macrophage-like immune cells which in turn signal back to tumorous epithelial cells to activate oncogenic JNK signaling. JNK further promotes and amplifies caspase activity, thereby constituting a feedback amplification loop. Interfering with the amplification loop strongly reduces the neoplastic behavior of these cells and significantly improves organismal survival. In conclusion, Ras(V12)-modified caspases initiate a feedback amplification loop involving tumorous epithelial cells and macrophage-like immune cells that is necessary for uncontrolled tumor growth and invasive behavior.
Kakimoto, Yu; Abiru, Hitoshi; Kotani, Hirokazu; Ozeki, Munetaka; Tsuruyama, Tatsuaki; Tamaki, Keiji
2012-01-10
We report a unique case of transmesenteric hernia resulting in death, which went undiagnosed during a recent hospital visit. The victim was a 2.5-year-old girl who - with the exception of chronic constipation - had no medical history. One night she complained of abdominal pains and was taken to a pediatric hospital where doctors performed an abdominal X-ray and echography. No significant findings suggesting bowel obstruction (e.g. air-fluid levels or dilation of the bowel) were obtained on examinations and bloody feces were not observed in this particular episode. As her abdominal pain gradually attenuated, the doctor allowed her to return home. A few hours later, she lost consciousness and expired despite resuscitation efforts attempted at an emergency hospital. A subsequent autopsy revealed that the small bowel had herniated through a defect in the mesentery resulting in two consecutive and inversely forming loops, in which each loop protruded on either side of the mesentery. This rare morphological anatomy seems to have progressed in a two-step process. The girl's mild abdominal pain was likely induced by herniation and formation of the first intestinal loop, followed by severe shock occurring when the subsequent intestinal segment invaginated into the same defect forming the second loop on the opposite side of the mesentery. This case illustrates the difficulty of diagnosing transmesenteric hernia due to the presentation of unspecific symptoms; especially in infants and toddlers. Furthermore, this report demonstrates the value of a complete autopsy in cases of sudden and unexpected deaths involving children. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Peters, Günther H.j.; Svendsen, A.; Langberg, H.;
1998-01-01
reveal that the hinges of the active site lid are more flexible in the wild-type Hll than in S146A. In contrast, larger fluctuations are observed in the middle region of the active site loop in S 146A than in Hll. These findings reveal that the single mutation (S146A) of the active site serine leads......We have investigated the binding properties of and dynamics in Humicola lanuginosa lipase (HII) and the inactive mutant S146A (active Ser146 substituted with Ala) using fluorescence spectroscopy and molecular dynamics simulations, respectively. Hll and S146A show significantly different binding......, whereas only small changes are observed for I-Ill suggesting that the active site Lid in the latter opens more easily and hence more lipase molecules are bound to the liposomes. These observations are in agreement with molecular dynamics simulations and subsequent essential dynamics analyses. The results...
HP1a/KDM4A is involved in the autoregulatory loop of the oncogene gene c-Jun.
Liu, Yan; Zhang, Daoyong
2015-01-01
The proto-oncogene c-Jun plays crucial roles in tumorigenesis, and its aberrant expression has been implicated in many cancers. Previous studies have shown that the c-Jun gene is positively autoregulated by its product. Notably, it has also been reported that c-Jun proteins are enriched in its gene body region. However, the role of c-Jun proteins in its gene body region has yet to be uncovered. HP1a is an evolutionarily conserved heterochromatin-associated protein, which plays an essential role in heterochromatin-mediated gene silencing. Interestingly, accumulating evidence shows that HP1a is also localized to euchromatic regions to positively regulate gene transcription. However, the underlying mechanism has not been defined. In this study, we demonstrate that HP1a is involved in the positive autoregulatory loop of the Jra gene, the c-Jun homolog in Drosophila. Jra recruits the HP1a/KDM4A complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation, resulting in high levels of histone acetylation in the Jra gene body region, thus promoting gene transcription. These results not only expand our knowledge toward the mechanism of c-Jun regulation, but also reveal the mechanism by which HP1a exerts its positive regulatory function in gene expression.
Boso, M; Emanuele, E; Prestori, Francesca; Politi, P; Barale, F; D'Angelo, E
2010-01-01
Mental processing is the product of the huge number of synaptic interactions that occur in the brain. It is easier to understand how brain functions can deteriorate than how they might be boosted. Lying at the border between the humanities, cognitive science and neurophysiology, some mental diseases offer new angles on this problematic issue. Despite their social deficits, autistic subjects can display unexpected and extraordinary skills in numerous fields, including music, the arts, calculation and memory. The advanced skills found in a subgroup of people with autism may be explained by their special mental functioning, in particular by their weak central coherence, one of the pivotal characteristics of the disorder. As a result of the increasing interest in autistic talent, there has recently emerged a tendency to screen any eccentric artist or scientist for traits of the autistic spectrum. Following this trend, we analyze the eccentricity of the popular pianist Glenn Gould and briefly discuss the major functional hypotheses on autistic hyperfunctioning, advancing proposals for functional testing. In particular, the potential involvement of rhythm-entrained systems and cerebro-cerebellar loops opens up new perspectives for the investigation of autistic disorders and brain hyperfunctioning.
Che, Qi; Liu, Bin-Ya; Wang, Fang-Yuan; He, Yin-Yan; Lu, Wen; Liao, Yun [Department of Obstetrics and Gynecology, Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai (China); Gu, Wei, E-mail: krisgu70@163.com [Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai (China); Wan, Xiao-Ping, E-mail: wanxp@sjtu.edu.cn [Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated to Tong Ji University, Shanghai (China)
2014-03-28
Highlights: • IL-6 could promote endometrial cancer cells proliferation. • IL-6 promotes its own production through an autocrine feedback loop. • ERK and NF-κB pathway inhibitors inhibit IL-6 production and tumor growth. • IL-6 secretion relies on the activation of ERK–NF-κB pathway axis. • An orthotopic nude endometrial carcinoma model confirms the effect of IL-6. - Abstract: Interleukin (IL)-6 as an inflammation factor, has been proved to promote cancer proliferation in several human cancers. However, its role in endometrial cancer has not been studied clearly. Previously, we demonstrated that IL-6 promoted endometrial cancer progression through local estrogen biosynthesis. In this study, we proved that IL-6 could directly stimulate endometrial cancer cells proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium. Next, we analyzed the mechanism underlying IL-6 production in the feedback loop and found that its production and IL-6-stimulated cell proliferation were effectively blocked by pharmacologic inhibitors of nuclear factor-kappa B (NF-κB) and extra-cellular signal-regulated kinase (ERK). Importantly, activation of ERK was upstream of the NF-κB pathways, revealing the hierarchy of this event. Finally, we used an orthotopic nude endometrial carcinoma model to confirm the effects of IL-6 on the tumor progression. Taken together, these data indicate that IL-6 promotes endometrial carcinoma growth through an expanded autocrine regulatory loop and implicate the ERK–NF-κB pathway as a critical mediator of IL-6 production, implying IL-6 to be an important therapeutic target in endometrial carcinoma.
PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.
Krysan, Kostyantyn; Kusko, Rebecca; Grogan, Tristan; O'Hearn, James; Reckamp, Karen L; Walser, Tonya C; Garon, Edward B; Lenburg, Marc E; Sharma, Sherven; Spira, Avrum E; Elashoff, David; Dubinett, Steven M
2014-05-01
Aberrant expression of microRNAs (miRNA) with oncogenic capacities (oncomiRs) has been described for several different malignancies. The first identified oncomiR, miR-17-92, is frequently overexpressed in a variety of cancers and its targets include the tumor suppressor PTEN. The transcription factor c-Myc (MYC) plays a central role in proliferative control and is rapidly upregulated upon mitogenic stimulation. Expression of c-Myc is frequently deregulated in tumors, facilitating proliferation and inhibiting terminal differentiation. The c-Myc-regulated network comprises a large number of transcripts, including those encoding miRNAs. Here, prostaglandin E2 (PGE2) exposure rapidly upregulates the expression of the MYC gene followed by the elevation of miR-17-92 levels, which in turn suppresses PTEN expression, thus enhancing apoptosis resistance in non-small cell lung cancer (NSCLC) cells. Knockdown of MYC expression or the miR-17-92 cluster effectively reverses this outcome. Similarly, miR-17-92 levels are significantly elevated in NSCLC cells ectopically expressing COX-2. Importantly, circulating miR-17-92 was elevated in the blood of patients with lung cancer as compared with subjects at risk for developing lung cancer. Furthermore, in patients treated with celecoxib, miR-17-92 levels were significantly reduced. These data demonstrate that PGE2, abundantly produced by NSCLC and inflammatory cells in the tumor microenvironment, is able to stimulate cell proliferation and promote resistance to pharmacologically induced apoptosis in a c-Myc and miR-17-92-dependent manner. This study describes a novel mechanism, involving c-Myc and miR-17-92, which integrates cell proliferation and apoptosis resistance. ©2014 AACR.
Harris, T; Shahidullah, M; Ellingson, J S; Covarrubias, M
2000-02-18
The structural bases of general anesthetic action on a neuronal K(+) channel were investigated using the series of homologous 1-alkanols, electrophysiology, and mutational analysis. Domain swapping between dShaw2 (alkanol-sensitive) and hKv3.4 (alkanol-resistant) and site-directed mutagenesis demonstrated that a 13-amino acid cytoplasmic loop (S4-S5) determines the selective inhibition of native dShaw2 channels by 1-alkanols. The S4-S5 loop may contribute to a receptor for both 1-alkanols and the inactivation particle, because the enhanced 1-alkanol sensitivity of hKv3.4 channels hosting S4-S5 mutations correlates directly with disrupted channel inactivation. Evidence of a discrete protein site was also obtained from the analysis of the relationship between potency and alkyl chain length, which begins to level off after 1-hexanol. Rapid application to the cytoplasmic side of inside-out membrane patches shows that the interaction between dShaw2 channels and 1-alkanols equilibrates in 1000-fold slower when the drug is applied externally to outside-out membrane patches. The data strongly favor a mechanism of inhibition involving a discrete internal site for 1-alkanols in dShaw2 K(+) channels. A new working hypothesis proposes that 1-alkanols lock dShaw2 channels in their closed conformation by a direct interaction at a crevice formed by the S4-S5 loop.
Padhy, B
2016-01-01
The simple method outlined in our earlier paper [B.Padhy, Orissa Journal of Physics, vol.19, No.1, p.1, February 2012] has been utilized here for analytic evaluation of three different five-electron atomic integrals with integrands involving products of s Slater-type orbitals and exponentially correlated functions of the form $r_{ij} exp(-\\lambda_{ij} r_{ij})$. Only products of those $r_{ij}$'s which do not form a closed loop by themselves, are considered.
Regulation of β-catenin nuclear dynamics by GSK-3β involves a LEF-1 positive feedback loop.
Jamieson, Cara; Sharma, Manisha; Henderson, Beric R
2011-08-01
Nuclear localization of β-catenin is integral to its role in Wnt signaling and cancer. Cellular stimulation by Wnt or lithium chloride (LiCl) inactivates glycogen synthase kinase-3β (GSK-3β), causing nuclear accumulation of β-catenin and transactivation of genes that transform cells. β-catenin is a shuttling protein; however, the mechanism by which GSK-3β regulates β-catenin nuclear dynamics is poorly understood. Here, fluorescence recovery after photobleaching assays were used to measure the β-catenin-green fluorescent protein dynamics in NIH 3T3 cells before and after GSK-3β inhibition. We show for the first time that LiCl and Wnt3a cause a specific increase in β-catenin nuclear retention in live cells and in fixed cells after detergent extraction. Moreover, LiCl reduced the rate of nuclear export but did not affect import, hence biasing β-catenin transport toward the nucleus. Interestingly, the S45A mutation, which blocks β-catenin phosphorylation by GSK-3β, did not alter nuclear retention or transport, implying that GSK-3β acts through an independent regulator. We compared five nuclear binding partners and identified LEF-1 as the key mediator of Wnt3a and LiCl-induced nuclear retention of β-catenin. Thus, Wnt stimulation triggered a LEF-1 positive feedback loop to enhance the nuclear chromatin-retained pool of β-catenin by 100-300%. These findings shed new light on regulation of β-catenin nuclear dynamics.
Herrera, D.; Bleijenbergh, I.L.
2016-01-01
Depression is a complex illness that involves the instability of biological and psychological structures in an individual. These disturbances make a depressed person to be affected in the personal relationships within his social circles and to be unable to fulfill normal daily activities as expected
Akasaka, Hironari; Thaliachery, Natasha; Zheng, Xianghai; Blumenthal, Marissa; Nikhar, Sameer; Murdoch, Emma E; Ling, Qinglan; Ruan, Ke-He
2017-02-15
Key residues and binding mechanisms of PGE1 and PGE2 on prostanoid receptors are poorly understood due to the lack of X-ray structures for the receptors. We constructed a human EP3 (hEP3) model through integrative homology modeling using the X-ray structure of the β2-adrenergic receptor transmembrane domain and NMR structures of the thromboxane A2 receptor extracellular loops. PGE1 and PGE2 docking into the hEP3 model showed differing configurations within the extracellular ligand recognition site. While PGE2 could form possible binding contact with S211, PGE1 is unable to form similar contacts. Therefore, S211 could be the critical residue for PGE2 recognition, but is not a significant for PGE1. This prediction was confirmed using HEK293 cells transfected with hEP3 S211L cDNA. The S211L cells lost PGE2 binding and signaling. Interestingly, the S211L cells retained PGE1-mediated signaling. It indicates that S211 within the second extracellular loop is a key residue involved in turning down PGE2 signaling. Our study provided information that S211L within EP3 is the key residue to distinguish PGE1 and PGE2 binding to mediate diverse biological functions at the initial recognition step. The S211L mutant could be used as a model for studying the binding mechanism and signaling pathway specifically mediated by PGE1. Copyright © 2017 Elsevier Inc. All rights reserved.
Qi Wang
2010-02-01
Full Text Available Hepatocellular carcinoma (HCC is one of the most common malignant tumors worldwide. Hepatitis B virus X protein (HBx contributes to the development of HCC, whereas HBx with COOH-terminal deletion is a frequent event in the HCC tissues. Previously, we identified a natural mutant of HBx-truncated 27 amino acids at the COOH-terminal (termed HBxΔ127, which strongly enhanced cell growth. In the present study, we focused on investigating the mechanism. Accordingly, fatty acid synthase (FAS plays a crucial role in cancer cell survival and proliferation; thus, we examined the signaling pathways involving FAS. Our data showed that HBxΔ127 strongly increased the transcriptional activities of FAS in human hepatoma HepG2 and H7402 cells. Moreover, we found that 5-lipoxygenase (5-LOX was responsible for the up-regulation of FAS by using MK886 (an inhibitor of 5-LOX and 5-LOX small interfering RNA. We observed that HBxΔ127 could upregulate 5-LOX through phosphorylated extracellular signal-regulated protein kinases 1/2 and thus resulted in the increase of released leukotriene B4 (LTB4, a metabolite of 5-LOX by ELISA. The additional LTB4 could upregulate the expression of FAS in the cells as well. Interestingly, we found that FAS was able to upregulate the expression of 5-LOX in a feedback manner by using cerulenin (an inhibitor of FAS. Collectively, HBxΔ127 promotes cell growth through a positive feedback loop involving 5-LOX and FAS, in which released LTB4 is involved in the up-regulation of FAS. Thus, our finding provides a new insight into the mechanism involving the promotion of cell growth mediated by HBxΔ127.
Subbiah Pugazhenthi
Full Text Available Proinflammatory cytokines secreted from microglia are known to induce a secondary immune response in astrocytes leading to an inflammatory loop. Cytokines also interfere with neurogenesis during aging and in neurodegenerative diseases. The present study examined the mechanism of induction of inflammatory mediators at the transcriptional level in human differentiated neuroprogenitor cells (NPCs. Interleukin-1β (IL-1β and tumor necrosis factor-α (TNF-α induced the expression of cytokines and chemokines in differentiated human NPCs as shown by an immune pathway-specific array. Network motif (NM analysis of these genes revealed 118 three-node NMs, suggesting complex interactions between inflammatory mediators and transcription factors. Immunofluorescent staining showed increases in the levels of IL-8 and CXCL10 proteins in neurons and glial cells. Findings from Taqman low density array suggested the synergistic actions of IL-1β and TNF-α in the induction of a majority of inflammatory genes by a mechanism involving NF-kB and STAT-1. Nuclear localization of these transcription factors in differentiated NPCs was observed following exposure to IL-1α and TNF-α. Further studies on CXCL10, a chemokine known to be elevated in the Alzheimer's brain, showed that TNF-α is a stronger inducer of CXCL10 promoter when compared to IL-1β. The synergy between these cytokines was lost when ISRE or kB elements in CXCL10 promoter were mutated. Our findings suggest that the activation of inflammatory pathways in neurons and astrocytes through transcription factors including NF-kB and STAT-1 play important roles in neuroglial interactions and in sustaining the vicious cycle of inflammatory response.
Zhao, Xiao-Ming; Liu, Chun; Li, Qiong-Yan; Hu, Wen-Bo; Zhou, Meng-Ting; Nie, Hong-Yi; Zhang, Yin-Xia; Peng, Zhang-Chuan; Zhao, Ping; Xia, Qing-You
2014-01-01
Silk glands are specialized in the synthesis of several secretory proteins. Expression of genes encoding the silk proteins in Bombyx mori silk glands with strict territorial and developmental specificities is regulated by many transcription factors. In this study, we have characterized B. mori sage, which is closely related to sage in the fruitfly Drosophila melanogaster. It is termed Bmsage; it encodes transcription factor Bmsage, which belongs to the Mesp subfamily, containing a basic helix-loop-helix motif. Bmsage transcripts were detected specifically in the silk glands of B. mori larvae through RT-PCR analysis. Immunoblotting analysis confirmed the Bmsage protein existed exclusively in B. mori middle and posterior silk gland cells. Bmsage has a low level of expression in the 4th instar molting stages, which increases gradually in the 5th instar feeding stages and then declines from the wandering to the pupation stages. Quantitative PCR analysis suggested the expression level of Bmsage in a high silk strain was higher compared to a lower silk strain on day 3 of the larval 5th instar. Furthermore, far western blotting and co-immunoprecipitation assays showed the Bmsage protein interacted with the fork head transcription factor silk gland factor 1 (SGF1). An electrophoretic mobility shift assay showed the complex of Bmsage and SGF1 proteins bound to the A and B elements in the promoter of fibroin H-chain gene(fib-H), respectively. Luciferase reporter gene assays confirmed the complex of Bmsage and SGF1 proteins increased the expression of fib-H. Together, these results suggest Bmsage is involved in the regulation of the expression of fib-H by being together with SGF1 in B. mori PSG cells.
Pamela J. Perez
2014-08-01
Full Text Available The looping of DNA provides a means of communication between sequentially distant genomic sites that operate in tandem to express, copy, and repair the information encoded in the DNA base sequence. The short loops implicated in the expression of bacterial genes suggest that molecular factors other than the naturally stiff double helix are involved in bringing the interacting sites into close spatial proximity. New computational techniques that take direct account of the three-dimensional structures and fluctuations of protein and DNA allow us to examine the likely means of enhancing such communication. Here, we describe the application of these approaches to the looping of a 92 base-pair DNA segment between the headpieces of the tetrameric Escherichia coli Lac repressor protein. The distortions of the double helix induced by a second protein—the nonspecific nucleoid protein HU—increase the computed likelihood of looping by several orders of magnitude over that of DNA alone. Large-scale deformations of the repressor, sequence-dependent features in the DNA loop, and deformability of the DNA operators also enhance looping, although to lesser degrees. The correspondence between the predicted looping propensities and the ease of looping derived from gene-expression and single-molecule measurements lends credence to the derived structural picture.
Nan HU; Yu LI; Yu ZHAO; Qi WANG; Jia-cong YOU; Xiao-dong ZHANG; Li-hong YE
2011-01-01
Aim: To investigate the endogenous signaling pathways associated with high proliferation potential of breast cancer cells.Methods: Breast cancer cell lines LM-MCF-7 and MCF-7 with high and low proliferation capability were used. The promoter activity of fatty acid synthase (FASN) was examined using luciferase reporter gene assay. The expression level of FASN mRNA was measured using RT-PCR and real time PCR, respectively. The level of leukotriene B4 (LTB4) was determined with ELISA. The expression levels of 5-lipoxygenase (5-LOX) was analyzed using RT-PCR and Western blot, respectively. 5-Bromo-20-deoxyuridine (BrdU) incorporation assay was used to study the proliferation of LM-MCF-7 and MCF-7 cells.Results: The promoter activity of FASN was significantly higher in LM-MCF-7 cells than MCF-7 cells. Treatment of LM-MCF-7 cells with ERK1/2 inhibitor PD98059 (30-50 μmol/L) or LOX inhibitor NDGA (25 μmol/L) abolished the activation of FASN. Moreover, treatment of LM-MCF-7 cells with the specific 5-LOX inhibitor MK-886 (20-40 μmol/L) or 5-LOX siRNA (50-100 nmol/L) decreased the promoter activity of FASN. The level of LTB4, the final metabolite produced by 5-LOX, was significantly higher in LM-MCF-7 cells than MCF-7 cells.Administration of exogenous LTB4 (1-10 nmol/L) was able to stimulate the promoter activity of FASN in MCF-7 cells. Treatment of LMMCF-7 cells with the FASN inhibitor cerulenin (10 μmol/L) reduced all the levels of p-ERK1/2, 5-LOX, and LTB4. Treatment of LM-MCF-7cells with cerulenin, PD98059, or MK-886 abolished the proliferation. Administration of exogenous LTB4 (10 nmol/L) significantly increased BrdU incorporation in MCF-7cells.Conclusion: These results suggest a novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN contributes to the sustaining growth of breast cancer LM-MCF-7 cells.
LoopIng: a template-based tool for predicting the structure of protein loops.
Messih, Mario Abdel
2015-08-06
Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure. This implies that, unlike the rest of the protein, standard homology modeling techniques are not very effective in modeling their structure. However, loops are often involved in protein function, hence inferring their structure is important for predicting protein structure as well as function.We describe a method, LoopIng, based on the Random Forest automated learning technique, which, given a target loop, selects a structural template for it from a database of loop candidates. Compared to the most recently available methods, LoopIng is able to achieve similar accuracy for short loops (4-10 residues) and significant enhancements for long loops (11-20 residues). The quality of the predictions is robust to errors that unavoidably affect the stem regions when these are modeled. The method returns a confidence score for the predicted template loops and has the advantage of being very fast (on average: 1 min/loop).www.biocomputing.it/loopinganna.tramontano@uniroma1.itSupplementary data are available at Bioinformatics online.
Quan-Lin Li
Full Text Available BACKGROUND: Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver transplantation. However, the objective response rates of rapamycin achieved with single-agent therapy were modest, supporting that rapamycin resistance is a frequently observed characteristic of many cancers. Some studies have been devoted to understanding the mechanisms of rapamycin resistance, however, the mechanisms are cell-type-dependent and studies on rapamycin resistance in HCC are extremely limited. METHODOLOGY/PRINCIPAL FINDINGS: The anti-tumor sensitivity of rapamycin was modest in vitro and in vivo. In both human and rat HCC cells, rapamycin up-regulated the expression and phosphorylation of PDGFRβ in a time and dose-dependent manner as assessed by RT-PCR and western blot analysis. Using siRNA mediated knockdown of PDGFRβ, we confirmed that subsequent activation of AKT and ERK was PDGFRβ-dependent and compromised the anti-tumor activity of rapamycin. Then, blockade of this PDGFRβ-dependent feedback loop by sorafenib enhanced the anti-tumor sensitivity of rapamycin in vitro and in an immunocompetent orthotopic rat model of HCC. CONCLUSIONS: Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop compromises the anti-tumor activity of rapamycin in HCC, and blockade of this feedback loop by sorafenib is an attractive approach to improve the anti-tumor effect of rapamycin, particularly in preventing or treating HCC recurrence after liver transplantation.
Hung, Jan-Jong; Hsieh, Meng-Ti; Young, Ming-Jer; Kao, Chuan-Liang; King, Chwan-Chuen; Chang, Wen
2004-01-01
Dengue virus (DV) is a flavivirus and infects mammalian cells through mosquito vectors. This study investigates the roles of domain III of DV type 2 envelope protein (EIII) in DV binding to the host cell. Recombinant EIII interferes with DV infection to BHK21 and C6/36 cells by blocking dengue virion adsorption to these cells. Inhibition of EIII on BHK21 cells was broad with no serotype specificity; however, inhibition of EIII on C6/36 cells was relatively serotype specific. Soluble heparin completely blocks binding of EIII to BHK21 cells, suggesting that domain III binds mainly to cell surface heparan sulfates. This suggestion is supported by the observation that EIII binds very weakly to gro2C and sog9 mutant mammalian cell lines that lack heparan sulfate. In contrast, heparin does not block binding of EIII to mosquito cells. Furthermore, a synthetic peptide that includes amino acids (aa) 380 to 389 of EIII, IGVEPGQLKL, inhibits binding of EIII to C6/36 but not BHK21 cells. This peptide corresponds to a lateral loop region on domain III of E protein, indicating a possible role of this loop in binding to mosquito cells. In summary, these results suggest that EIII plays an important role in binding of DV type 2 to host cells. In addition, EIII interacts with heparan sulfates when binding to BHK21 cells, and a loop region containing aa 380 to 389 of EIII may participate in DV type 2 binding to C6/36 cells.
Warne, Larry Kevin; Lucero, Larry Martin; Langston, William L.; Salazar, Robert Austin; Coleman, Phillip Dale; Basilio, Lorena I.; Bacon, Larry Donald
2012-05-01
This report estimates inductively-coupled energy to a low-impedance load in a loop-to-loop arrangement. Both analytical models and full-wave numerical simulations are used and the resulting fields, coupled powers and energies are compared. The energies are simply estimated from the coupled powers through approximations to the energy theorem. The transmitter loop is taken to be either a circular geometry or a rectangular-loop (stripline-type) geometry that was used in an experimental setup. Simple magnetic field models are constructed and used to estimate the mutual inductance to the receiving loop, which is taken to be circular with one or several turns. Circuit elements are estimated and used to determine the coupled current and power (an equivalent antenna picture is also given). These results are compared to an electromagnetic simulation of the transmitter geometry. Simple approximate relations are also given to estimate coupled energy from the power. The effect of additional loads in the form of attached leads, forming transmission lines, are considered. The results are summarized in a set of susceptibility-type curves. Finally, we also consider drives to the cables themselves and the resulting common-to-differential mode currents in the load.
Tejral, Gracian; Sopko, Bruno; Necas, Alois; Schoner, Wilhelm
2017-01-01
Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases reveals that binding of ATP to the N-domain connected by a hinge to the P-domain is much too far away from the Asp369 to allow the transfer of ATP’s terminal phosphate to its aspartyl-phosphorylation site. In order to get information for how the transfer of the γ-phosphate group of ATP to the Asp369 is achieved, analogous molecular modeling of the M4–M5 loop of ATPase was performed using the crystal data of Na+/K+-ATPase of different species. Analogous molecular modeling of the cytoplasmic loop between Thr338 and Ile760 of the α2-subunit of Na+/K+-ATPase and the analysis of distances between the ATP binding site and phosphorylation site revealed the existence of two ATP binding sites in the open conformation; the first one close to Phe475 in the N-domain, the other one close to Asp369 in the P-domain. However, binding of Mg2+•ATP to any of these sites in the “open conformation” may not lead to phosphorylation of Asp369. Additional conformations of the cytoplasmic loop were found wobbling between “open conformation” “semi-open conformation “closed conformation” in the absence of 2Mg2+•ATP. The cytoplasmic loop’s conformational change to the “semi-open conformation”—characterized by a hydrogen bond between Arg543 and Asp611—triggers by binding of 2Mg2+•ATP to a single ATP site and conversion to the “closed conformation” the phosphorylation of Asp369 in the P-domain, and hence the start of Na+/K+-activated ATP hydrolysis. PMID:28316890
Gracian Tejral
2017-03-01
Full Text Available Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases reveals that binding of ATP to the N-domain connected by a hinge to the P-domain is much too far away from the Asp369 to allow the transfer of ATP’s terminal phosphate to its aspartyl-phosphorylation site. In order to get information for how the transfer of the γ-phosphate group of ATP to the Asp369 is achieved, analogous molecular modeling of the M4–M5 loop of ATPase was performed using the crystal data of Na+/K+-ATPase of different species. Analogous molecular modeling of the cytoplasmic loop between Thr338 and Ile760 of the α2-subunit of Na+/K+-ATPase and the analysis of distances between the ATP binding site and phosphorylation site revealed the existence of two ATP binding sites in the open conformation; the first one close to Phe475 in the N-domain, the other one close to Asp369 in the P-domain. However, binding of Mg2+•ATP to any of these sites in the “open conformation” may not lead to phosphorylation of Asp369. Additional conformations of the cytoplasmic loop were found wobbling between “open conformation” “semi-open conformation “closed conformation” in the absence of 2Mg2+•ATP. The cytoplasmic loop’s conformational change to the “semi-open conformation”—characterized by a hydrogen bond between Arg543 and Asp611—triggers by binding of 2Mg2+•ATP to a single ATP site and conversion to the “closed conformation” the phosphorylation of Asp369 in the P-domain, and hence the start of Na+/K+-activated ATP hydrolysis.
Katayama, Hirofumi; Iwamoto, Kuninori; Kariya, Yuka; Asakawa, Tomohiro; Kan, Toshiyuki; Fukuda, Hiroo; Ohashi-Ito, Kyoko
2015-12-07
Controlling cell division and differentiation in meristems is essential for proper plant growth. Two bHLH heterodimers consisting of LONESOME HIGHWAY (LHW) and TARGET OF MONOPTEROS 5 (TMO5)/TMO5-LIKE1 (T5L1) regulate periclinal cell division in vascular cells in the root apical meristem (RAM). In this study, we further investigated the functions of LHW-T5L1, finding that in addition to controlling cell division, this complex regulates xylem differentiation in the RAM via a novel negative regulatory system. LHW-T5L1 upregulated the thermospermine synthase gene ACAULIS5 (ACL5), as well as SUPPRESSOR OF ACAULIS5 LIKE3 (SACL3), which encodes a bHLH protein, in the RAM. The SACL3 promoter sequence contains a conserved upstream open reading frame (uORF), which blocked translation of the main SACL3 ORF in the absence of thermospermine. Thermospermine eliminated the negative effect of uORF and enhanced SACL3 production. Further genetic and molecular biological analyses indicated that ACL5 and SACL3 suppress the function of LHW-T5L1 through a protein-protein interaction between LHW and SACL3. Finally, we showed that a negative feedback loop consisting of LHW-T5L1, ACL5, SACL3, and LHW-SACL3 contributes to maintain RAM size and proper root growth. These findings suggest that a negative feedback loop regulates the LHW-T5L1 output level to coordinate cell division and differentiation in a cell-autonomous manner. Copyright © 2015 Elsevier Ltd. All rights reserved.
Schonauer, Sophie; Körschen, Heinz G; Penno, Anke; Rennhack, Andreas; Breiden, Bernadette; Sandhoff, Konrad; Gutbrod, Katharina; Dörmann, Peter; Raju, Diana N; Haberkant, Per; Gerl, Mathias J; Brügger, Britta; Zigdon, Hila; Vardi, Ayelet; Futerman, Anthony H; Thiele, Christoph; Wachten, Dagmar
2017-03-03
The lysosomal acid beta-glucosidase GBA1 and the non-lysosomal beta-glucosidase GBA2 degrade glucosylceramide (GlcCer) to glucose and ceramide in different cellular compartments. Loss of GBA2 activity and the resulting accumulation of GlcCer results in male infertility, whereas mutations in the GBA1 gene and loss of GBA1 activity cause the lipid-storage disorder Gaucher disease. However, the role of GBA2 in Gaucher disease pathology and its relationship to GBA1 is not well understood. Here, we report a GBA1-dependent down-regulation of GBA2 activity in patients with Gaucher disease. Using an experimental approach combining cell biology, biochemistry, and mass spectrometry, we show that sphingosine, the cytotoxic metabolite accumulating in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its activity. We propose a negative feed-back loop, in which sphingosine inhibits GBA2 activity in Gaucher cells, preventing further sphingosine accumulation and, thereby, cytotoxicity. Our findings add a new chapter to the understanding of the complex molecular mechanism underlying Gaucher disease and the regulation of beta-glucosidase activity in general.
Gherardi, Samuele; Scarlett, Christopher J.; Bedalov, Antonio; Xu, Ning; Iraci, Nuncio; Valli, Emanuele; Ling, Dora; Thomas, Wayne; van Bekkum, Margo; Sekyere, Eric; Jankowski, Kacper; Trahair, Toby; MacKenzie, Karen L.; Haber, Michelle; Norris, Murray D.; Biankin, Andrew V.; Perini, Giovanni; Liu, Tao
2011-01-01
The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedback loop whereby N-Myc directly induced the transcription of the class III histone deacetylase SIRT1, which in turn increased N-Myc protein stability. SIRT1 binds to Myc Box I domain of N-Myc protein to form a novel transcriptional repressor complex at gene promoter of mitogen-activated protein kinase phosphatase 3 (MKP3), leading to transcriptional repression of MKP3, ERK protein phosphorylation, N-Myc protein phosphorylation at Serine 62, and N-Myc protein stabilization. Importantly, SIRT1 was up-regulated, MKP3 down-regulated, in pre-cancerous cells, and preventative treatment with the SIRT1 inhibitor Cambinol reduced tumorigenesis in TH-MYCN transgenic mice. Our data demonstrate the important roles of SIRT1 in N-Myc oncogenesis and SIRT1 inhibitors in the prevention and therapy of N-Myc–induced neuroblastoma. PMID:21698133
Takaharu Yamamoto
2017-01-01
Full Text Available Type 4 P-type ATPases (P4-ATPases function as phospholipid flippases, which translocate phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of the lipid bilayer, to generate and maintain asymmetric distribution of phospholipids at the plasma membrane and endosomal/Golgi membranes. The budding yeast Saccharomyces cerevisiae has four heteromeric flippases (Drs2p, Dnf1p, Dnf2p, and Dnf3p, associated with the Cdc50p family noncatalytic subunit, and one monomeric flippase, Neo1p. They have been suggested to function in vesicle formation in membrane trafficking pathways, but details of their mechanisms remain to be clarified. Here, to search for novel factors that functionally interact with flippases, we screened transposon insertional mutants for strains that suppressed the cold-sensitive growth defect in the cdc50Δ mutant. We identified a mutation of YMR010W encoding a novel conserved membrane protein that belongs to the PQ-loop family including the cystine transporter cystinosin and the SWEET sugar transporters. We named this gene CFS1 (cdc fifty suppressor 1. GFP-tagged Cfs1p was partially colocalized with Drs2p and Neo1p to endosomal/late Golgi membranes. Interestingly, the cfs1Δ mutation suppressed growth defects in all flippase mutants. Accordingly, defects in membrane trafficking in the flippase mutants were also suppressed. These results suggest that Cfs1p and flippases function antagonistically in membrane trafficking pathways. A growth assay to assess sensitivity to duramycin, a phosphatidylethanolamine (PE-binding peptide, suggested that the cfs1Δ mutation changed PE asymmetry in the plasma membrane. Cfs1p may thus be a novel regulator of phospholipid asymmetry.
Kong, Ling-Min; Liao, Cheng-Gong; Zhang, Yang; Xu, Jing; Li, Yu; Huang, Wan; Zhang, Yi; Bian, Huijie; Chen, Zhi-Nan
2014-07-15
Breast cancer is the most common cancer in women for which the metastatic process is still poorly understood. CD147 is upregulated in breast cancer and has been associated with tumor progression, but little is known about its regulatory mechanisms. In this study, we demonstrated that CD147 was overexpressed in breast cancer tissues and cell lines, and the high expression correlated with tumor invasion and metastasis. We also found that the transcription factors Sp1 and c-Myc could bind to the CD147 promoter and enhance its expression. The CD147 mRNA has a 748-bp 3'-untranslated region (UTR) with many miRNA target sites, suggesting possible regulation by miRNAs. We discovered that miR-22 repressed CD147 expression by directly targeting the CD147 3'UTR. We also determined that miR-22 could indirectly participate in CD147 modulation by downregulating Sp1 expression. miR-22 could form an autoregulatory loop with Sp1, which repressed miR-22 transcription by binding to the miR-22 promoter. Together with the c-Myc-mediated inhibition of miR-22 expression, our investigation identified a miR-22/Sp1/c-Myc network that regulates CD147 gene transcription. In addition, miR-22 overexpression suppressed breast cancer cell invasion, metastasis, and proliferation by targeting CD147 in vitro and in vivo. Furthermore, we found that miR-22 was significantly downregulated in breast cancer tissues and that its expression was inversely correlated with the tumor-node-metastasis stage and lymphatic metastasis in patients. Our study provides the first evidence that an miR-22/Sp1/c-Myc network regulates CD147 upregulation in breast cancer and that miR-22 represses breast cancer invasive and metastatic capacities.
Repetto, Emanuela; Briata, Paola; Kuziner, Nathalie; Harfe, Brian D; McManus, Michael T; Gherzi, Roberto; Rosenfeld, Michael G; Trabucchi, Michele
2012-01-01
Gene silencing mediated by either microRNAs (miRNAs) or Adenylate/uridylate-rich elements Mediated mRNA Degradation (AMD) is a powerful way to post-transcriptionally modulate gene expression. We and others have reported that the RNA-binding protein KSRP favors the biogenesis of select miRNAs (including let-7 family) and activates AMD promoting the decay of inherently labile mRNAs. Different layers of interplay between miRNA- and AMD-mediated gene silencing have been proposed in cultured cells, but the relationship between the two pathways in living organisms is still elusive. We conditionally deleted Dicer in mouse pituitary from embryonic day (E) 9.5 through Cre-mediated recombination. In situ hybridization, immunohistochemistry, and quantitative reverse transcriptase-PCR revealed that Dicer is essential for pituitary morphogenesis and correct expression of hormones. Strikingly, αGSU (alpha glycoprotein subunit, common to three pituitary hormones) was absent in Dicer-deleted pituitaries. αGSU mRNA is unstable and its half-life increases during pituitary development. A transcriptome-wide analysis of microdissected E12.5 pituitaries revealed a significant increment of KSRP expression in conditional Dicer-deleted mice. We found that KSRP directly binds to αGSU mRNA, promoting its rapid decay; and, during pituitary development, αGSU expression displays an inverse temporal relationship to KSRP. Further, let-7b/c downregulated KSRP expression, promoting the degradation of its mRNA by directly binding to the 3'UTR. Therefore, we propose a model in which let-7b/c and KSRP operate within a negative feedback loop. Starting from E12.5, KSRP induces the maturation of let-7b/c that, in turn, post-transcriptionally downregulates the expression of KSRP itself. This event leads to stabilization of αGSU mRNA, which ultimately enhances the steady-state expression levels. We have identified a post-transcriptional regulatory network active during mouse pituitary development in
Emanuela Repetto
Full Text Available Gene silencing mediated by either microRNAs (miRNAs or Adenylate/uridylate-rich elements Mediated mRNA Degradation (AMD is a powerful way to post-transcriptionally modulate gene expression. We and others have reported that the RNA-binding protein KSRP favors the biogenesis of select miRNAs (including let-7 family and activates AMD promoting the decay of inherently labile mRNAs. Different layers of interplay between miRNA- and AMD-mediated gene silencing have been proposed in cultured cells, but the relationship between the two pathways in living organisms is still elusive. We conditionally deleted Dicer in mouse pituitary from embryonic day (E 9.5 through Cre-mediated recombination. In situ hybridization, immunohistochemistry, and quantitative reverse transcriptase-PCR revealed that Dicer is essential for pituitary morphogenesis and correct expression of hormones. Strikingly, αGSU (alpha glycoprotein subunit, common to three pituitary hormones was absent in Dicer-deleted pituitaries. αGSU mRNA is unstable and its half-life increases during pituitary development. A transcriptome-wide analysis of microdissected E12.5 pituitaries revealed a significant increment of KSRP expression in conditional Dicer-deleted mice. We found that KSRP directly binds to αGSU mRNA, promoting its rapid decay; and, during pituitary development, αGSU expression displays an inverse temporal relationship to KSRP. Further, let-7b/c downregulated KSRP expression, promoting the degradation of its mRNA by directly binding to the 3'UTR. Therefore, we propose a model in which let-7b/c and KSRP operate within a negative feedback loop. Starting from E12.5, KSRP induces the maturation of let-7b/c that, in turn, post-transcriptionally downregulates the expression of KSRP itself. This event leads to stabilization of αGSU mRNA, which ultimately enhances the steady-state expression levels. We have identified a post-transcriptional regulatory network active during mouse pituitary
Hard Loops, Soft Loops, and High Density Effective Field Theory
Schäfer, T
2003-01-01
We study several issues related to the use of effective field theories in QCD at large baryon density. We show that the power counting is complicated by the appearance of two scales inside loop integrals. Hard dense loops involve the large scale $mu^2$ and lead to phenomena such as screening and damping at the scale $gmu$. Soft loops only involve small scales and lead to superfluidity and non-Fermi liquid behavior at exponentially small scales. Four-fermion operators in the effective theory are suppressed by powers of $1/mu$, but they get enhanced by hard loops. As a consequence their contribution to the pairing gap is only suppressed by powers of the coupling constant, and not powers of $1/mu$. We determine the coefficients of four-fermion operators in the effective theory by matching quark-quark scattering amplitudes. Finally, we introduce a perturbative scheme for computing corrections to the gap parameter in the superfluid phase
Goodaire, EG; Polcino Milies, C
1996-01-01
For the past ten years, alternative loop rings have intrigued mathematicians from a wide cross-section of modern algebra. As a consequence, the theory of alternative loop rings has grown tremendously. One of the main developments is the complete characterization of loops which have an alternative but not associative, loop ring. Furthermore, there is a very close relationship between the algebraic structures of loop rings and of group rings over 2-groups. Another major topic of research is the study of the unit loop of the integral loop ring. Here the interaction between loop rings and group ri
Bojowald Martin
2008-07-01
Full Text Available Quantum gravity is expected to be necessary in order to understand situations in which classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical spacetime inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding spacetime is then modified. One particular theory is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. The main effects are introduced into effective classical equations, which allow one to avoid the interpretational problems of quantum theory. They give rise to new kinds of early-universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function, which allows an extension of quantum spacetime beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of spacetime arising in loop quantum gravity and its application to cosmology sheds light on more general issues, such as the nature of time.
Bojowald Martin
2005-12-01
Full Text Available Quantum gravity is expected to be necessary in order to understand situations where classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical space-time inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding space-time is then modified. One particular realization is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. Main effects are introduced into effective classical equations which allow to avoid interpretational problems of quantum theory. They give rise to new kinds of early universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function which allows to extend space-time beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of space-time arising in loop quantum gravity and its application to cosmology sheds new light on more general issues such as time.
nf2 contributions to fermionic four-loop form factors
Lee, Roman N.; Smirnov, Alexander V.; Smirnov, Vladimir A.; Steinhauser, Matthias
2017-07-01
We compute the four-loop contributions to the photon quark and Higgs quark form factors involving two closed fermion loops. We present analytical results for all nonplanar master integrals of the two nonplanar integral families which enter our calculation.
Vacuum Energy Sequestering and Graviton Loops
Kaloper, Nemanja
2016-01-01
We recently formulated a local mechanism of vacuum energy sequester. This mechanism automatically removes all matter loop contributions to vacuum energy from the stress energy tensor which sources the curvature. Here we adapt the local vacuum energy sequestering mechanism to also cancel all the vacuum energy loops involving virtual gravitons, in addition to the vacuum energy generated by matter fields alone.
Vacuum Energy Sequestering and Graviton Loops
Kaloper, Nemanja; Padilla, Antonio
2016-01-01
We recently formulated a local mechanism of vacuum energy sequester. This mechanism automatically removes all matter loop contributions to vacuum energy from the stress energy tensor which sources the curvature. Here we adapt the local vacuum energy sequestering mechanism to also cancel all the vacuum energy loops involving virtual gravitons, in addition to the vacuum energy generated by matter fields alone.
Baumeister, Barbara
2009-01-01
We continue the work by Aschbacher, Kinyon and Phillips [AKP] as well as of Glauberman [Glaub1,2] by describing the structure of the finite Bruck loops. We show essentially that a finite Bruck loop $X$ is the direct product of a Bruck loop of odd order with either a soluble Bruck loop of 2-power order or a product of loops related to the groups $PSL_2(q)$, $q= 9$ or $q \\geq 5$ a Fermat prime. The latter possibillity does occur as is shown in [Nag1, BS]. As corollaries we obtain versions of Sylow's, Lagrange's and Hall's Theorems for loops.
Pseudonoise code tracking loop
Laflame, D. T. (Inventor)
1980-01-01
A delay-locked loop is presented for tracking a pseudonoise (PN) reference code in an incoming communication signal. The loop is less sensitive to gain imbalances, which can otherwise introduce timing errors in the PN reference code formed by the loop.
Zhang, Qinghao; Xie, Dizhi; Wang, Shuqi; You, Cuihong; Monroig, Oscar; Tocher, Douglas R; Li, Yuanyou
2014-07-01
Biosynthesis in vertebrates of long-chain polyunsaturated fatty acids (LC-PUFA) such as arachidonic (ARA; 20:4n-6), eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids requires the catalysis by fatty acyl desaturases (Fads). A vertebrate Fad with Δ4 activity catalyzing the direct conversion of 22:5n-3 to DHA was discovered in the marine teleost rabbitfish Siganus canaliculatus. Recent studies in vertebrates have shown that miRNAs may participate in the regulation of lipid metabolism at post-transcription level. However, their roles in LC-PUFA biosynthesis were not known. In the present study, in silico analysis predicts that the rabbitfish Δ4 Fad may be a target of miR-17 and thus we cloned miR-17, which is located at the forepart of the miR-17-92 cluster. Dual luciferase reporter assays demonstrated that miR-17 targeted the 3'UTR of Δ4 Fad directly. Furthermore, the expression level of miR-17 displayed an inverse pattern with that of Δ4 Fad mRNA in gill, liver and eyes, and also the Δ4 Fad protein quantity in rabbitfish liver. Incubation of rabbitfish primary hepatocytes with linoleic acid (LA; 18:2n-6), α-linolenic acid (LNA; 18:3n-3), EPA or DHA showed differential effects on miR-17, Δ4 Fad and Δ6/Δ5 Fad expression. LNA promoted the expression of miR-17 and Δ6/Δ5 Fad, but suppressed the expression of Δ4 Fad. In contrast, LA and EPA decreased the expression of miR-17 and Δ6/Δ5 Fad, but had no effect on Δ4 Fad. However, all the above were down-regulated by DHA. These data indicate that miR-17 was involved in the regulation of LC-PUFA biosynthesis in rabbitfish liver by targeting Δ4 Fad.
张克勇; 周国华
2011-01-01
Based on the game theory, the differential price coordination is addressed in this paper for a closed-loop supply chain with third-party collection of used products. First, the decentralized and centralized differential pricing models are established. With them, the optimal pricing strategy and the optimal profit for the members in a closed-loop supply chain are analyzed. Then,it is found that efficiency is lost in the decentralized closed-loop supply chain. Finally,it puts forward a profit-sharing coordination contract to coordinate the closed-loop supply chain, which makes the profit of the decentralized closed-loop supply chain equal to that of the integrated closed-loop supply chain.%以博弈论为基本研究方法,研究了第三方负责回收的闭环供应链系统差别定价协调契约的设计问题.构建了三方非合作分散决策情形和合作集中决策情形下的系统差别定价模型,分析得到了两种情形下闭环供应链系统成员的最优定价策略和利润,发现三方分散决策会造成系统效率的损失.由此,提出了一种收益分享协调契约,实现了闭环供应链系统的协调,并使供应链系统整体利润达到集中决策时的利润水平.
Supersymmetric Wilson loops at two loops
Bassetto, Antonio; Pucci, Fabrizio; Seminara, Domenico
2008-01-01
We study the quantum properties of certain BPS Wilson loops in ${\\cal N}=4$ supersymmetric Yang-Mills theory. They belong to a general family, introduced recently, in which the addition of particular scalar couplings endows generic loops on $S^3$ with a fraction of supersymmetry. When restricted to $S^2$, their quantum average has been further conjectured to be exactly computed by the matrix model governing the zero-instanton sector of YM$_2$ on the sphere. We perform a complete two-loop analysis on a class of cusped Wilson loops lying on a two-dimensional sphere, finding perfect agreement with the conjecture. The perturbative computation reproduces the matrix-model expectation through a highly non-trivial interplay between ladder diagrams and self-energies/vertex contributions, suggesting the existence of a localization procedure.
Blanco-Pillado, Jose J; Shlaer, Benjamin
2015-01-01
We analyze the shapes of cosmic string loops found in large-scale simulations of an expanding-universe string network. The simulation does not include gravitational back reaction, but we model that process by smoothing the loop using Lorentzian convolution. We find that loops at formation consist of generally straight segments separated by kinks. We do not see cusps or any cusp-like structure at the scale of the entire loop, although we do see very small regions of string that move with large Lorentz boosts. However, smoothing of the string almost always introduces two cusps on each loop. The smoothing process does not lead to any significant fragmentation of loops that were in non-self-intersecting trajectories before smoothing.
Blok, Rieuwert J
2011-01-01
In 1974 Orin Chein discovered a new family of Moufang loops which are now called Chein loops. Such a loop can be created from any group $W$ together with $\\mathbb{Z}_2$ by a variation on a semi-direct product. We study these loops in the case where $W$ is a Coxeter group and show that it has what we call a Chein-Coxeter system, a small set of generators of order 2, together with a set of relations closely related to the Coxeter relations and Chein relations. As a result we are able to give amalgam presentations for Coxeter-Chein loops. This is to our knowledge the first such presentation for a Moufang loop.
Remarks on correlators of Polyakov Loops
Neuberger, Herbert
2013-01-01
Polyakov loop eigenvalues and their N-dependence are studied in 2 and 4 dimensional SU(N) YM theory. The connected correlation function of the single eigenvalue distributions of two separated Polyakov loops in 2D YM is calculated and is found to have a structure differing from the one of corresponding hermitian random matrix ensembles. No large $N$ non-analyticities are found for two point functions in the confining regime. Suggestions are made for situations in which large-N phase transitions involving Polyakov loops might occur.
Wilson Loop Form Factors: A New Duality
Chicherin, Dmitry; Heslop, Paul; Korchemsky, Gregory P.; Sokatchev, Emery
2016-01-01
We find a new duality for form factors of lightlike Wilson loops in planar $\\mathcal N=4$ super-Yang-Mills theory. The duality maps a form factor involving an $n$-sided lightlike polygonal super-Wilson loop together with $m$ external on-shell states, to the same type of object but with the edges of the Wilson loop and the external states swapping roles. This relation can essentially be seen graphically in Lorentz harmonic chiral (LHC) superspace where it is equivalent to planar graph duality....
Blok, Rieuwert J.; Gagola III, Stephen
2011-01-01
In 1974 Orin Chein discovered a new family of Moufang loops which are now called Chein loops. Such a loop can be created from any group $W$ together with $\\mathbb{Z}_2$ by a variation on a semi-direct product. We study these loops in the case where $W$ is a Coxeter group and show that it has what we call a Chein-Coxeter system, a small set of generators of order 2, together with a set of relations closely related to the Coxeter relations and Chein relations. As a result we are able to give am...
Observational Evidence for Loop-Loop Interaction
Guiping, W.; Guangli, H.; Yuhua, T.; Aoao, X.
2004-01-01
Through analysis of the data including the hard x-ray(BASTE) microwave(NoRP) and magnetogram(MDI from SOHO) as well as the images of soft x-ray(YHKOH) and EIT(SOHO) on Apr. 151998 solar flare in the active region 8203(N30W12) we found: (1) there are similar quasi period oscillation in the profile of hard x-ray flux (25-5050-100keV) and microwave flux(1GHz) with duration of 85+/-25s every peak includes two sub-peak structures; (2) in the preheat phase of the flare active magnetic field changes apparently and a s-pole spot emerges ; (3) several EIT and soft x-ray loops exist and turn into bright . All of these may suggest that loop-loop interaction indeed exist. Through reconnection the electrons may be accelerated and the hard x-ray and microwave emission take place.
Jacquenet, S; Ropers, D; Bilodeau, P S; Damier, L; Mougin, A; Stoltzfus, C M; Branlant, C
2001-01-15
The HIV-1 transcript is alternatively spliced to over 30 different mRNAs. Whether RNA secondary structure can influence HIV-1 RNA alternative splicing has not previously been examined. Here we have determined the secondary structure of the HIV-1/BRU RNA segment, containing the alternative A3, A4a, A4b, A4c and A5 3' splice sites. Site A3, required for tat mRNA production, is contained in the terminal loop of a stem-loop structure (SLS2), which is highly conserved in HIV-1 and related SIVcpz strains. The exon splicing silencer (ESS2) acting on site A3 is located in a long irregular stem-loop structure (SLS3). Two SLS3 domains were protected by nuclear components under splicing condition assays. One contains the A4c branch points and a putative SR protein binding site. The other one is adjacent to ESS2. Unexpectedly, only the 3' A residue of ESS2 was protected. The suboptimal A3 polypyrimidine tract (PPT) is base paired. Using site-directed mutagenesis and transfection of a mini-HIV-1 cDNA into HeLa cells, we found that, in a wild-type PPT context, a mutation of the A3 downstream sequence that reinforced SLS2 stability decreased site A3 utilization. This was not the case with an optimized PPT. Hence, sequence and secondary structure of the PPT may cooperate in limiting site A3 utilization.
Testing loop quantum cosmology
Wilson-Ewing, Edward
2017-03-01
Loop quantum cosmology predicts that quantum gravity effects resolve the big-bang singularity and replace it by a cosmic bounce. Furthermore, loop quantum cosmology can also modify the form of primordial cosmological perturbations, for example by reducing power at large scales in inflationary models or by suppressing the tensor-to-scalar ratio in the matter bounce scenario; these two effects are potential observational tests for loop quantum cosmology. In this article, I review these predictions and others, and also briefly discuss three open problems in loop quantum cosmology: its relation to loop quantum gravity, the trans-Planckian problem, and a possible transition from a Lorentzian to a Euclidean space-time around the bounce point.
Ladd-Lively, Jennifer L [ORNL
2008-10-01
The objectives of the work discussed in this report were to: (1) develop a flow loop that would simulate the purified uranium-bearing aqueous stream exiting the solvent extraction process in a natural uranium conversion plant (NUCP); (2) develop a test plan that would simulate normal operation and disturbances that could be anticipated in an NUCP; (3) use the flow loop to test commercially available flowmeters for use as safeguards monitors; and (4) recommend a flowmeter for production-scale testing at an NUCP. There has been interest in safeguarding conversion plants because the intermediate products [uranium dioxide (UO{sub 2}), uranium tetrafluoride (UF{sub 4}), and uranium hexafluoride (UF{sub 6})] are all suitable uranium feedstocks for producing special nuclear materials. Furthermore, if safeguards are not applied virtually any nuclear weapons program can obtain these feedstocks without detection by the International Atomic Energy Agency (IAEA). Historically, IAEA had not implemented safeguards until the purified UF{sub 6} product was declared as feedstock for enrichment plants. H. A. Elayat et al. provide a basic definition of a safeguards system: 'The function of a safeguards system on a chemical conversion plant is in general terms to verify that no useful nuclear material is being diverted to use in a nuclear weapons program'. The IAEA now considers all highly purified uranium compounds as candidates for safeguarding. DOE is currently interested in 'developing instruments, tools, strategies, and methods that could be of use to the IAEA in the application of safeguards' for materials found in the front end of the nuclear fuel cycle-prior to the production of the uranium hexafluoride or oxides that have been the traditional starting point for IAEA safeguards. Several national laboratories, including Oak Ridge, Los Alamos, Lawrence Livermore, and Brookhaven, have been involved in developing tools or techniques for safeguarding conversion
Numerical multi-loop integrals and applications
Freitas, Ayres
2016-01-01
Higher-order radiative corrections play an important role in precision studies of the electroweak and Higgs sector, as well as for the detailed understanding of large backgrounds to new physics searches. For corrections beyond the one-loop level and involving many independent mass and momentum scales, it is in general not possible to find analytic results, so that one needs to resort to numerical methods instead. This article presents an overview over a variety of numerical loop integration techniques, highlighting their range of applicability, suitability for automatization, and numerical precision and stability. In a second part of this article, the application of numerical loop integration methods in the area of electroweak precision tests is illustrated. Numerical methods were essential for obtaining full two-loop predictions for the most important precision observables within the Standard Model. The theoretical foundations for these corrections will be described in some detail, including aspects of the r...
Capillary fluid loop developments in Astrium
Figus, C.; Ounougha, L.; Bonzom, P. [Astrium SAS, Toulouse (France); Supper, W. [ESA/ESTEC, Noordwijk (Netherlands); Puillet, C. [CNES, Toulouse (France)
2003-06-01
Over the past decade, Astrium has been involved in the development of capillary pumped fluid loops. In the frame of the French technological demonstrator spacecraft called STENTOR, Astrium has gained experience on capillary fluid loop design and manufacturing. After the STENTOR cylindrical evaporator type was successfully tested and qualified, Astrium has developed miniaturised fluid loops for thermal dissipation of electronic devices. For such applications, the use of a flat shape evaporator is very promising, limiting the volume and the mass of the thermal hardware. Both technologies have been submitted to a comprehensive one-g test program and will be flight-tested in the near future. Through a comparative of the reached performances, some main advantages and drawbacks of each design are listed and a definition of what should be the next generation of Astrium fluid loops is given. (author)
Natively unstructured loops differ from other loops.
Avner Schlessinger
2007-07-01
Full Text Available Natively unstructured or disordered protein regions may increase the functional complexity of an organism; they are particularly abundant in eukaryotes and often evade structure determination. Many computational methods predict unstructured regions by training on outliers in otherwise well-ordered structures. Here, we introduce an approach that uses a neural network in a very different and novel way. We hypothesize that very long contiguous segments with nonregular secondary structure (NORS regions differ significantly from regular, well-structured loops, and that a method detecting such features could predict natively unstructured regions. Training our new method, NORSnet, on predicted information rather than on experimental data yielded three major advantages: it removed the overlap between testing and training, it systematically covered entire proteomes, and it explicitly focused on one particular aspect of unstructured regions with a simple structural interpretation, namely that they are loops. Our hypothesis was correct: well-structured and unstructured loops differ so substantially that NORSnet succeeded in their distinction. Benchmarks on previously used and new experimental data of unstructured regions revealed that NORSnet performed very well. Although it was not the best single prediction method, NORSnet was sufficiently accurate to flag unstructured regions in proteins that were previously not annotated. In one application, NORSnet revealed previously undetected unstructured regions in putative targets for structural genomics and may thereby contribute to increasing structural coverage of large eukaryotic families. NORSnet found unstructured regions more often in domain boundaries than expected at random. In another application, we estimated that 50%-70% of all worm proteins observed to have more than seven protein-protein interaction partners have unstructured regions. The comparative analysis between NORSnet and DISOPRED2 suggested
Natively unstructured loops differ from other loops.
Schlessinger, Avner; Liu, Jinfeng; Rost, Burkhard
2007-07-01
Natively unstructured or disordered protein regions may increase the functional complexity of an organism; they are particularly abundant in eukaryotes and often evade structure determination. Many computational methods predict unstructured regions by training on outliers in otherwise well-ordered structures. Here, we introduce an approach that uses a neural network in a very different and novel way. We hypothesize that very long contiguous segments with nonregular secondary structure (NORS regions) differ significantly from regular, well-structured loops, and that a method detecting such features could predict natively unstructured regions. Training our new method, NORSnet, on predicted information rather than on experimental data yielded three major advantages: it removed the overlap between testing and training, it systematically covered entire proteomes, and it explicitly focused on one particular aspect of unstructured regions with a simple structural interpretation, namely that they are loops. Our hypothesis was correct: well-structured and unstructured loops differ so substantially that NORSnet succeeded in their distinction. Benchmarks on previously used and new experimental data of unstructured regions revealed that NORSnet performed very well. Although it was not the best single prediction method, NORSnet was sufficiently accurate to flag unstructured regions in proteins that were previously not annotated. In one application, NORSnet revealed previously undetected unstructured regions in putative targets for structural genomics and may thereby contribute to increasing structural coverage of large eukaryotic families. NORSnet found unstructured regions more often in domain boundaries than expected at random. In another application, we estimated that 50%-70% of all worm proteins observed to have more than seven protein-protein interaction partners have unstructured regions. The comparative analysis between NORSnet and DISOPRED2 suggested that long
Introduction to Loop Heat Pipes
Ku, Jentung
2015-01-01
This is the presentation file for the short course Introduction to Loop Heat Pipes, to be conducted at the 2015 Thermal Fluids and Analysis Workshop, August 3-7, 2015, Silver Spring, Maryland. This course will discuss operating principles and performance characteristics of a loop heat pipe. Topics include: 1) pressure profiles in the loop; 2) loop operating temperature; 3) operating temperature control; 4) loop startup; 4) loop shutdown; 5) loop transient behaviors; 6) sizing of loop components and determination of fluid inventory; 7) analytical modeling; 8) examples of flight applications; and 9) recent LHP developments.
Closed-loop neuromorphic benchmarks
Stewart
2015-11-01
Full Text Available Benchmarks Terrence C. Stewart 1* , Travis DeWolf 1 , Ashley Kleinhans 2 , Chris Eliasmith 1 1 University of Waterloo, Canada, 2 Council for Scientific and Industrial Research, South Africa Submitted to Journal: Frontiers in Neuroscience Specialty... the study was exempt from ethical approval procedures.) Did the study presented in the manuscript involve human or animal subjects: No I v i w 1Closed-loop Neuromorphic Benchmarks Terrence C. Stewart 1,∗, Travis DeWolf 1, Ashley Kleinhans 2 and Chris...
Bojowald, Martin
2013-01-01
Inhomogeneous space-times in loop quantum cosmology have come under better control with recent advances in effective methods. Even highly inhomogeneous situations, for which multiverse scenarios provide extreme examples, can now be considered at least qualitatively.
... part of the stomach) and operations for extreme obesity As a complication of inflammatory bowel disease Diseases such as diabetes or scleroderma may slow down movement in a segment of the intestine, leading to blind loop syndrome.
Brzoska, A M; Negele, J W; Thies, M
2004-01-01
A phenomenological analysis of the distribution of Wilson loops in SU(2) Yang-Mills theory is presented in which Wilson loop distributions are described as the result of a diffusion process on the group manifold. It is shown that, in the absence of forces, diffusion implies Casimir scaling and, conversely, exact Casimir scaling implies free diffusion. Screening processes occur if diffusion takes place in a potential. The crucial distinction between screening of fundamental and adjoint loops is formulated as a symmetry property related to the center symmetry of the underlying gauge theory. The results are expressed in terms of an effective Wilson loop action and compared with various limits of SU(2) Yang-Mills theory.
Neuberger, H
2010-01-01
The generating function for all antisymmetric characters of a Wilson loop matrix in SU(N) Yang Mills theory is the partition function of a fermion living on the curve describing the loop. This generalizes to fermion subsystems living on higher dimensional submanifolds, for example, surfaces. This write-up also contains some extra background, in response to some questions raised during the oral presentation.
Multi-loop calculations: numerical methods and applications arXiv
Borowka, S.; Jahn, S.; Jones, S.P.; Kerner, M.; Schlenk, J.
We briefly review numerical methods for calculations beyond one loop and then describe new developments within the method of sector decomposition in more detail. We also discuss applications to two-loop integrals involving several mass scales.
Genetic Programming with Simple Loops
QI Yuesheng; WANG Baozhong; KANG Lishan
1999-01-01
A kind of loop function LoopN inGenetic Programming (GP) is proposed.Different from other forms of loopfunction, such as While-Do and Repeat-Until, LoopNtakes only oneargument as its loop body and makes its loop body simply run N times,soinfinite loops will never happen. The problem of how to avoid too manylayers ofloops in Genetic Programming is also solved. The advantage ofLoopN in GP is shown bythe computational results in solving the mowerproblem.
Disconnected Loops with Twisted Mass Lattice QCD
Wilcox, W; Morgan, R; Lewis, R; Wilcox, Walter; Darnell, Dean; Morgan, Ron; Lewis, Randy
2005-01-01
We give a general introduction and discussion of the issues involved in using the twisted mass formulation of lattice fermions in the context of disconnected loop calculations, including a short orientation on the present experimental situation for nucleon strange quark form factors. A prototype calculation of the disconnected part of the nucleon scalar form factor is described.
Loop electrosurgical excisional procedure.
Mayeaux, E J; Harper, M B
1993-02-01
Loop electrosurgical excisional procedure, or LEEP, also known as loop diathermy treatment, loop excision of the transformation zone (LETZ), and large loop excision of the transformation zone (LLETZ), is a new technique for outpatient diagnosis and treatment of dysplastic cervical lesions. This procedure produces good specimens for cytologic evaluation, carries a low risk of affecting childbearing ability, and is likely to replace cryotherapy or laser treatment for cervical neoplasias. LEEP uses low-current, high-frequency electrical generators and thin stainless steel or tungsten loops to excise either lesions or the entire transformation zone. Complication rates are comparable to cryotherapy or laser treatment methods and include bleeding, incomplete removal of the lesion, and cervical stenosis. Compared with other methods, the advantages of LEEP include: removal of abnormal tissue in a manner permitting cytologic study, low cost, ease of acquiring necessary skills, and the ability to treat lesions with fewer visits. Patient acceptance of the procedure is high. Widespread use of LEEP by family physicians can be expected.
An optimal open/closed-loop control method with application to a pre-stressed thin duralumin plate
Nadimpalli, Sruthi Raju
The excessive vibrations of a pre-stressed duralumin plate, suppressed by a combination of open-loop and closed-loop controls, also known as open/closed-loop control, is studied in this thesis. The two primary steps involved in this process are: Step (I) with an assumption that the closed-loop control law is proportional, obtain the optimal open-loop control by direct minimization of the performance measure consisting of energy at terminal time and a penalty on open-loop control force via calculus of variations. If the performance measure also involves a penalty on closed-loop control effort then a Fourier based method is utilized. Step (II) the energy at terminal time is minimized numerically to obtain optimal values of feedback gains. The optimal closed-loop control gains obtained are used to describe the displacement and the velocity of open-loop, closed-loop and open/closed-loop controlled duralumin plate.
Bena, I; Kosower, D A; Roiban, R; Bena, Iosif; Bern, Zvi; Kosower, David A.; Roiban, Radu
2004-01-01
We elucidate the one-loop twistor-space structure corresponding to momentum-space MHV diagrams. We also discuss the infrared divergences, and argue that only a limited set of MHV diagrams contain them. We show how to introduce a twistor-space regulator corresponding to dimensional regularization for the infrared-divergent diagrams. We also evaluate explicitly the `holomorphic anomaly' pointed out by Cachazo, Svrcek, and Witten, and use the result to define modified differential operators which can be used to probe the twistor-space structure of one-loop amplitudes.
Closed Loop Subspace Identification
Geir W. Nilsen
2005-07-01
Full Text Available A new three step closed loop subspace identifications algorithm based on an already existing algorithm and the Kalman filter properties is presented. The Kalman filter contains noise free states which implies that the states and innovation are uneorre lated. The idea is that a Kalman filter found by a good subspace identification algorithm will give an output which is sufficiently uncorrelated with the noise on the output of the actual process. Using feedback from the output of the estimated Kalman filter in the closed loop system a subspace identification algorithm can be used to estimate an unbiased model.
Chiou, Dah-Wei
2014-01-01
This article presents an "in-a-nutshell" yet self-contained introductory review on loop quantum gravity (LQG) -- a background-independent, nonperturbative approach to a consistent quantum theory of gravity. Instead of rigorous and systematic derivations, it aims to provide a general picture of LQG, placing emphasis on the fundamental ideas and their significance. The canonical formulation of LQG, as the central topic of the article, is presented in a logically orderly fashion with moderate details, while the spin foam theory, black hole thermodynamics, and loop quantum cosmology are covered briefly. Current directions and open issues are also summarized.
Saccade learning with concurrent cortical and subcortical basal ganglia loops
Steve eN'guyen
2014-04-01
Full Text Available The Basal Ganglia is a central structure involved in multiple cortical and subcortical loops. Some of these loops are believed to be responsible for saccade target selection. We study here how the very specific structural relationships of these saccadic loops can affect the ability of learning spatial and feature-based tasks.We propose a model of saccade generation with reinforcement learning capabilities based onour previous basal ganglia and superior colliculus models. It is structured around the interactions of two parallel cortico-basal loops and one tecto-basal loop. The two cortical loops separately deal with spatial and non-spatial information to select targets in a concurrent way. The subcortical loop is used to make the final target selection leading to the production of thesaccade. These different loops may work in concert or disturb each other regarding reward maximization. Interactions between these loops and their learning capabilities are tested on different saccade tasks.The results show the ability of this model to correctly learn basic target selection based on different criteria (spatial or not. Moreover the model reproduces and explains training dependent express saccades toward targets based on a spatial criterion. Finally, the model predicts that in absence of prefrontal control, the spatial loop should dominate.
Rovelli Carlo
1998-01-01
Full Text Available The problem of finding the quantum theory of the gravitational field, and thus understanding what is quantum spacetime, is still open. One of the most active of the current approaches is loop quantum gravity. Loop quantum gravity is a mathematically well-defined, non-perturbative and background independent quantization of general relativity, with its conventional matter couplings. Research in loop quantum gravity today forms a vast area, ranging from mathematical foundations to physical applications. Among the most significant results obtained are: (i The computation of the physical spectra of geometrical quantities such as area and volume, which yields quantitative predictions on Planck-scale physics. (ii A derivation of the Bekenstein-Hawking black hole entropy formula. (iii An intriguing physical picture of the microstructure of quantum physical space, characterized by a polymer-like Planck scale discreteness. This discreteness emerges naturally from the quantum theory and provides a mathematically well-defined realization of Wheeler's intuition of a spacetime ``foam''. Long standing open problems within the approach (lack of a scalar product, over-completeness of the loop basis, implementation of reality conditions have been fully solved. The weak part of the approach is the treatment of the dynamics: at present there exist several proposals, which are intensely debated. Here, I provide a general overview of ideas, techniques, results and open problems of this candidate theory of quantum gravity, and a guide to the relevant literature.
Reversible hysteresis loop tuning
Berger, A.; Binek, Ch.; Margulies, D. T.; Moser, A.; Fullerton, E. E.
2006-02-01
We utilize antiferromagnetically coupled bilayer structures to magnetically tune hysteresis loop properties. Key element of this approach is the non-overlapping switching field distribution of the two magnetic layers that make up the system: a hard magnetic CoPtCrB layer (HL) and a soft magnetic CoCr layer (SL). Both layers are coupled antiferromagnetically through an only 0.6-nm-thick Ru interlayer. The non-overlapping switching field distribution allows the measurement of magnetization reversal in the SL at low fields while keeping the magnetization state of the HL unperturbed. Applying an appropriate high field or high field sequence changes the magnetic state of the HL, which then influences the SL magnetization reversal due to the interlayer coupling. In this way, the position and shape of the SL hysteresis loop can be changed or tuned in a fully reversible and highly effective manner. Here, we study specifically how the SL hysteresis loop characteristics change as we move the HL through an entire high field hysteresis loop sequence.
Covariant diagrams for one-loop matching
Zhang, Zhengkang
2016-01-01
We present a diagrammatic formulation of recently-revived covariant functional approaches to one-loop matching from an ultraviolet (UV) theory to a low-energy effective field theory. Various terms following from a covariant derivative expansion (CDE) are represented by diagrams which, unlike conventional Feynman diagrams, involve gauge-covariant quantities and are thus dubbed "covariant diagrams." The use of covariant diagrams helps organize and simplify one-loop matching calculations, which we illustrate with examples. Of particular interest is the derivation of UV model-independent universal results, which reduce matching calculations of specific UV models to applications of master formulas. We show how such derivation can be done in a more concise manner than the previous literature, and discuss how additional structures that are not directly captured by existing universal results, including mixed heavy-light loops, open covariant derivatives, and mixed statistics, can be easily accounted for.
Covariant diagrams for one-loop matching
Zhang, Zhengkang [Michigan Univ., Ann Arbor, MI (United States). Michigan Center for Theoretical Physics; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)
2016-10-15
We present a diagrammatic formulation of recently-revived covariant functional approaches to one-loop matching from an ultraviolet (UV) theory to a low-energy effective field theory. Various terms following from a covariant derivative expansion (CDE) are represented by diagrams which, unlike conventional Feynman diagrams, involve gaugecovariant quantities and are thus dubbed ''covariant diagrams.'' The use of covariant diagrams helps organize and simplify one-loop matching calculations, which we illustrate with examples. Of particular interest is the derivation of UV model-independent universal results, which reduce matching calculations of specific UV models to applications of master formulas. We show how such derivation can be done in a more concise manner than the previous literature, and discuss how additional structures that are not directly captured by existing universal results, including mixed heavy-light loops, open covariant derivatives, and mixed statistics, can be easily accounted for.
Two-loop and n-loop eikonal vertex corrections
Kidonakis, Nikolaos
2003-01-01
I present calculations of two-loop vertex corrections with massive and massless partons in the eikonal approximation. I show that the $n$-loop result for the UV poles can be given in terms of the one-loop calculation.
Franetič, Damir
2015-01-01
We study loop near-rings, a generalization of near-rings, where the additive structure is not necessarily associative. We introduce local loop near-rings and prove a useful detection principle for localness.
Griego, J R
1995-01-01
Some features of extended loops are considered. In particular, the behaviour under diffeomorphism transformations of the wavefunctions with support on the extended loop space are studied. The basis of a method to obtain analytical expressions of diffeomorphism invariants via extended loops are settled. Applications to knot theory and quantum gravity are considered.
Prosman, Ernst-Jan; Wæhrens, Brian Vejrum; Liotta, Giacomo
2017-01-01
Replacing virgin materials with waste materials, a practice known as Industrial Symbiosis (IS), has been identified as a key strategy for closing material loops. This article adopts a critical view on geographic proximity and external coordinators – two key enablers of IS. By ‘uncovering’ a case...... where both enablers are absent, this study seeks to explore firm-level challenges of IS. We adopt an exploratory case study approach at a cement manufacturer who engages in cross-border IS without the support of external coordinators. Our research presents insights into two key areas of IS: 1) setting...... for geographic proximity and external coordinators. In doing so, our insights into firm-level challenges of long-distance IS exchanges contribute to closing global material loops by increasing the number of potential circular pathways....
Schaffer, Jr.; W.F.
1958-04-30
The schedule for the installation of the PAR slurry loop experiment in the South Facility of the ORR has been reviewed and revised. The design, fabrications and Installation is approximately two weeks behind schedule at this time due to many factors; however, indications are that this time can be made up. Design is estimated to be 75% complete, fabrication 32% complete and installation 12% complete.
Verification of Loop Diagnostics
Winebarger, A.; Lionello, R.; Mok, Y.; Linker, J.; Mikic, Z.
2014-01-01
Many different techniques have been used to characterize the plasma in the solar corona: density-sensitive spectral line ratios are used to infer the density, the evolution of coronal structures in different passbands is used to infer the temperature evolution, and the simultaneous intensities measured in multiple passbands are used to determine the emission measure. All these analysis techniques assume that the intensity of the structures can be isolated through background subtraction. In this paper, we use simulated observations from a 3D hydrodynamic simulation of a coronal active region to verify these diagnostics. The density and temperature from the simulation are used to generate images in several passbands and spectral lines. We identify loop structures in the simulated images and calculate the loop background. We then determine the density, temperature and emission measure distribution as a function of time from the observations and compare with the true temperature and density of the loop. We find that the overall characteristics of the temperature, density, and emission measure are recovered by the analysis methods, but the details of the true temperature and density are not. For instance, the emission measure curves calculated from the simulated observations are much broader than the true emission measure distribution, though the average temperature evolution is similar. These differences are due, in part, to inadequate background subtraction, but also indicate a limitation of the analysis methods.
Cosmic string loop microlensing
Bloomfield, Jolyon K.; Chernoff, David F.
2014-06-01
Cosmic superstring loops within the galaxy microlens background point sources lying close to the observer-string line of sight. For suitable alignments, multiple paths coexist and the (achromatic) flux enhancement is a factor of two. We explore this unique type of lensing by numerically solving for geodesics that extend from source to observer as they pass near an oscillating string. We characterize the duration of the flux doubling and the scale of the image splitting. We probe and confirm the existence of a variety of fundamental effects predicted from previous analyses of the static infinite straight string: the deficit angle, the Kaiser-Stebbins effect, and the scale of the impact parameter required to produce microlensing. Our quantitative results for dynamical loops vary by O(1) factors with respect to estimates based on infinite straight strings for a given impact parameter. A number of new features are identified in the computed microlensing solutions. Our results suggest that optical microlensing can offer a new and potentially powerful methodology for searches for superstring loop relics of the inflationary era.
A class of optimum digital phase locked loops
Kumar, R.; Hurd, W. J.
1986-01-01
This paper presents a class of optimum digital filters for digital phase locked loops, for the important case in which the maximum update rate of the loop filter and numerically controlled oscillator (NCO) is limited. This case is typical when the loop filter is implemented in a microprocessor. In these situations, pure delay is encountered in the loop transfer function and thus the stability and gain margin of the loop are of crucial interest. The optimum filters designed for such situations are evaluated in terms of their gain margin for stability, dynamic error, and steady-state error performance. For situations involving considerably high phase dynamics an adaptive and programmable implementation is also proposed to obtain an overall optimum strategy.
Finding the positive feedback loops underlying multi-stationarity
Feliu, Elisenda; Wiuf, Carsten
2015-01-01
BACKGROUND: Bistability is ubiquitous in biological systems. For example, bistability is found in many reaction networks that involve the control and execution of important biological functions, such as signaling processes. Positive feedback loops, composed of species and reactions, are necessary...... for bistability, and generally for multi-stationarity, to occur. These loops are therefore often used to illustrate and pinpoint the parts of a multi-stationary network that are relevant ('responsible') for the observed multi-stationarity. However positive feedback loops are generally abundant in reaction...... networks but not all of them are important for understanding the network's dynamics. RESULTS: We present an automated procedure to determine the relevant positive feedback loops of a multi-stationary reaction network. The procedure only reports the loops that are relevant for multi-stationarity (that is...
Two-loop Bethe-logarithm correction in hydrogenlike atoms.
Pachucki, Krzysztof; Jentschura, Ulrich D
2003-09-12
We calculate the two-loop Bethe logarithm correction to atomic energy levels in hydrogenlike systems. The two-loop Bethe logarithm is a low-energy quantum electrodynamic (QED) effect involving multiple summations over virtual excited atomic states. Although much smaller in absolute magnitude than the well-known one-loop Bethe logarithm, the two-loop analog is quite significant when compared to the current experimental accuracy of the 1S-2S transition: It contributes -8.19 and -0.84 kHz for the 1S and the 2S state, respectively. The two-loop Bethe logarithm has been the largest unknown correction to the hydrogen Lamb shift to date. Together with the ongoing measurement of the proton charge radius at the Paul Scherrer Institute, its calculation will bring theoretical and experimental accuracy for the Lamb shift in atomic hydrogen to the level of 10(-7).
Finding the positive feedback loops underlying multi-stationarity
Feliu, Elisenda; Wiuf, Carsten
2015-01-01
BACKGROUND: Bistability is ubiquitous in biological systems. For example, bistability is found in many reaction networks that involve the control and execution of important biological functions, such as signaling processes. Positive feedback loops, composed of species and reactions, are necessary...... for bistability, and generally for multi-stationarity, to occur. These loops are therefore often used to illustrate and pinpoint the parts of a multi-stationary network that are relevant ('responsible') for the observed multi-stationarity. However positive feedback loops are generally abundant in reaction...... networks but not all of them are important for understanding the network's dynamics. RESULTS: We present an automated procedure to determine the relevant positive feedback loops of a multi-stationary reaction network. The procedure only reports the loops that are relevant for multi-stationarity (that is...
Improving Loop Dependence Analysis
Jensen, Nicklas Bo; Karlsson, Sven
2017-01-01
Programmers can no longer depend on new processors to have significantly improved single-thread performance. Instead, gains have to come from other sources such as the compiler and its optimization passes. Advanced passes make use of information on the dependencies related to loops. We improve...... the quality of that information by reusing the information given by the programmer for parallelization. We have implemented a prototype based on GCC into which we also add a new optimization pass. Our approach improves the amount of correctly classified dependencies resulting in 46% average improvement...
Dassau, E; Atlas, E; Phillip, M
2011-02-01
Closed-loop algorithms can be found in every aspect of everyday modern life. Automation and control are used constantly to provide safety and to improve quality of life. Closed-loop systems and algorithms can be found in home appliances, automobiles, aviation and more. Can one imagine nowadays driving a car without ABS, cruise control or even anti-sliding control? Similar principles of automation and control can be used in the management of diabetes mellitus (DM). The idea of an algorithmic/technological way to control glycaemia is not new and has been researched for more than four decades. However, recent improvements in both glucose-sensing technology and insulin delivery together with advanced control and systems engineering made this dream of an artificial pancreas possible. The artificial pancreas may be the next big step in the treatment of DM since the use of insulin analogues. An artificial pancreas can be described as internal or external devices that use continuous glucose measurements to automatically manage exogenous insulin delivery with or without other hormones in an attempt to restore glucose regulation in individuals with DM using a control algorithm. This device as described can be internal or external; can use different types of control algorithms with bi-hormonal or uni-hormonal design; and can utilise different ways to administer them. The different designs and implementations have transitioned recently from in silico simulations to clinical evaluation stage with practical applications in mind. This may mark the beginning of a new era in diabetes management with the introduction of semi-closed-loop systems that can prevent or minimise nocturnal hypoglycaemia, to hybrid systems that will manage blood glucose (BG) levels with minimal user intervention to finally fully automated systems that will take the user out of the loop. More and more clinical trials will be needed for the artificial pancreas to become a reality but initial encouraging
Numerical multi-loop integrals and applications
Freitas, A.
2016-09-01
Higher-order radiative corrections play an important role in precision studies of the electroweak and Higgs sector, as well as for the detailed understanding of large backgrounds to new physics searches. For corrections beyond the one-loop level and involving many independent mass and momentum scales, it is in general not possible to find analytic results, so that one needs to resort to numerical methods instead. This article presents an overview of a variety of numerical loop integration techniques, highlighting their range of applicability, suitability for automatization, and numerical precision and stability. In a second part of this article, the application of numerical loop integration methods in the area of electroweak precision tests is illustrated. Numerical methods were essential for obtaining full two-loop predictions for the most important precision observables within the Standard Model. The theoretical foundations for these corrections will be described in some detail, including aspects of the renormalization, resummation of leading log contributions, and the evaluation of the theory uncertainty from missing higher orders.
Loop expansion and the bosonic representation of loop quantum gravity
Bianchi, E.; Guglielmon, J.; Hackl, L.; Yokomizo, N.
2016-10-01
We introduce a new loop expansion that provides a resolution of the identity in the Hilbert space of loop quantum gravity on a fixed graph. We work in the bosonic representation obtained by the canonical quantization of the spinorial formalism. The resolution of the identity gives a tool for implementing the projection of states in the full bosonic representation onto the space of solutions to the Gauss and area matching constraints of loop quantum gravity. This procedure is particularly efficient in the semiclassical regime, leading to explicit expressions for the loop expansions of coherent, heat kernel and squeezed states.
Loop expansion and the bosonic representation of loop quantum gravity
Bianchi, Eugenio; Hackl, Lucas; Yokomizo, Nelson
2016-01-01
We introduce a new loop expansion that provides a resolution of the identity in the Hilbert space of loop quantum gravity on a fixed graph. We work in the bosonic representation obtained by the canonical quantization of the spinorial formalism. The resolution of the identity gives a tool for implementing the projection of states in the full bosonic representation onto the space of solutions to the Gauss and area matching constraints of loop quantum gravity. This procedure is particularly efficient in the semiclassical regime, leading to explicit expressions for the loop expansions of coherent, heat kernel and squeezed states.
High temperature storage loop :
Gill, David Dennis; Kolb, William J.
2013-07-01
A three year plan for thermal energy storage (TES) research was created at Sandia National Laboratories in the spring of 2012. This plan included a strategic goal of providing test capability for Sandia and for the nation in which to evaluate high temperature storage (>650ÀC) technology. The plan was to scope, design, and build a flow loop that would be compatible with a multitude of high temperature heat transfer/storage fluids. The High Temperature Storage Loop (HTSL) would be reconfigurable so that it was useful for not only storage testing, but also for high temperature receiver testing and high efficiency power cycle testing as well. In that way, HTSL was part of a much larger strategy for Sandia to provide a research and testing platform that would be integral for the evaluation of individual technologies funded under the SunShot program. DOEs SunShot program seeks to reduce the price of solar technologies to 6/kWhr to be cost competitive with carbon-based fuels. The HTSL project sought to provide evaluation capability for these SunShot supported technologies. This report includes the scoping, design, and budgetary costing aspects of this effort
High temperature storage loop :
Gill, David Dennis; Kolb, William J.
2013-07-01
A three year plan for thermal energy storage (TES) research was created at Sandia National Laboratories in the spring of 2012. This plan included a strategic goal of providing test capability for Sandia and for the nation in which to evaluate high temperature storage (>650ÀC) technology. The plan was to scope, design, and build a flow loop that would be compatible with a multitude of high temperature heat transfer/storage fluids. The High Temperature Storage Loop (HTSL) would be reconfigurable so that it was useful for not only storage testing, but also for high temperature receiver testing and high efficiency power cycle testing as well. In that way, HTSL was part of a much larger strategy for Sandia to provide a research and testing platform that would be integral for the evaluation of individual technologies funded under the SunShot program. DOEs SunShot program seeks to reduce the price of solar technologies to 6/kWhr to be cost competitive with carbon-based fuels. The HTSL project sought to provide evaluation capability for these SunShot supported technologies. This report includes the scoping, design, and budgetary costing aspects of this effort
A simple gastropexy for the loop-gastrostomy tube
Pang Ah-San
2012-01-01
Full Text Available The percutaneous endoscopic gastrostomy has been in clinical use for more than three decades. A recent innovation, the loop-gastrostomy, is more suitable for developing countries because the tube cannot be dislodged and is easy to change. Gastropexy and gastrostomy are separate but related moieties. We describe a novel technique to add a gastropexy to the loop-gastrostomy, using it successfully in a man with permanent dysphagia. It involved creating a secondary loop at the mid-portion of the LOOPPEG® 3G tube with absorbable ligatures.
Vandemeulebroucke, An; De Vos, Stefan; Van Holsbeke, Els; Steyaert, Jan; Versées, Wim
2008-08-08
The nucleoside hydrolase of Trypanosoma vivax hydrolyzes the N-glycosidic bond of purine nucleosides. Structural and kinetic studies on this enzyme have suggested a catalytic role for a flexible loop in the vicinity of the active sites. Here we present the analysis of the role of this flexible loop via the combination of a proline scan of the loop, loop deletion mutagenesis, steady state and pre-steady state analysis, and x-ray crystallography. Our analysis reveals that this loop has an important role in leaving group activation and product release. The catalytic role involves the entire loop and could only be perturbed by deletion of the entire loop and not by single site mutagenesis. We present evidence that the loop closes over the active site during catalysis, thereby ordering a water channel that is involved in leaving group activation. Once chemistry has taken place, the loop dynamics determine the rate of product release.
Condition Monitoring of Control Loops
Horch, Alexander
2000-01-01
The main concern of this work is the development of methodsfor automatic condition monitoring of control loops withapplication to the process industry. By condition monitoringboth detection and diagnosis of malfunctioning control loops isunderstood, using normal operating data and a minimum amount ofprocess knowledge. The use of indices for quantifying loop performance is dealtwith in the first part of the thesis. The starting point is anindex proposed by Harris (1989). This index has been mo...
Loop Heat Pipe Startup Behaviors
Ku, Jentung
2016-01-01
A loop heat pipe must start successfully before it can commence its service. The startup transient represents one of the most complex phenomena in the loop heat pipe operation. This paper discusses various aspects of loop heat pipe startup behaviors. Topics include the four startup scenarios, the initial fluid distribution between the evaporator and reservoir that determines the startup scenario, factors that affect the fluid distribution between the evaporator and reservoir, difficulties encountered during the low power startup, and methods to enhance the startup success. Also addressed are the pressure spike and pressure surge during the startup transient, and repeated cycles of loop startup and shutdown under certain conditions.
Designing Estimator/Predictor Digital Phase-Locked Loops
Statman, J. I.; Hurd, W. J.
1988-01-01
Signal delays in equipment compensated automatically. New approach to design of digital phase-locked loop (DPLL) incorporates concepts from estimation theory and involves decomposition of closed-loop transfer function into estimator and predictor. Estimator provides recursive estimates of phase, frequency, and higher order derivatives of phase with respect to time, while predictor compensates for delay, called "transport lag," caused by PLL equipment and by DPLL computations.
Pei, L.; Klebaner, A.; Theilacker, J.; Soyars, W.; Martinez, A.; Bossert, R.; DeGraff, B.; Darve, C.; /Fermilab
2011-06-01
The Horizontal Test Stand (HTS) SRF Cavity and Cryomodule 1 (CM1) of eight 9-cell, 1.3GHz SRF cavities are operating at Fermilab. For the cryogenic control system, how to hold liquid level constant in the cryostat by regulation of its Joule-Thompson JT-valve is very important after cryostat cool down to 2.0 K. The 72-cell cryostat liquid level response generally takes a long time delay after regulating its JT-valve; therefore, typical PID control loop should result in some cryostat parameter oscillations. This paper presents a type of PID parameter self-optimal and Time-Delay control method used to reduce cryogenic system parameters oscillation.
Paul, Clayton R
2010-01-01
"Inductance is an unprecedented text, thoroughly discussing "loop" inductance as well as the increasingly important "partial" inductance. These concepts and their proper calculation are crucial in designing modern high-speed digital systems. World-renowned leader in electromagnetics Clayton Paul provides the knowledge and tools necessary to understand and calculate inductance." "With the present and increasing emphasis on high-speed digital systems and high-frequency analog systems, it is imperative that system designers develop an intimate understanding of the concepts and methods in this book. Inductance is a much-needed textbook designed for senior and graduate-level engineering students, as well as a hands-on guide for working engineers and professionals engaged in the design of high-speed digital and high-frequency analog systems."--Jacket.
Pei, L; Theilacker, J; Soyars, W; Martinez, A; Bossert, R; DeGraff, B; Darve, C
2012-01-01
The Horizontal Test Stand (HTS) SRF Cavity and Cryomodule 1 (CM1) of eight 9-cell, 1.3GHz SRF cavities are operating at Fermilab. For the cryogenic control system, how to hold liquid level constant in the cryostat by regulation of its Joule-Thompson JT-valve is very important after cryostat cool down to 2.0 K. The 72-cell cryostat liquid level response generally takes a long time delay after regulating its JT-valve; therefore, typical PID control loop should result in some cryostat parameter oscillations. This paper presents a type of PID parameter self-optimal and Time-Delay control method used to reduce cryogenic system parameters' oscillation.
Chesi, Stefano [Department of Physics, McGill University, Montreal, Quebec H3A 2T8 (Canada); CEMS, RIKEN, Wako, Saitama 351-0198 (Japan); Jaffe, Arthur [Harvard University, Cambridge, Massachusetts 02138 (United States); Department of Physics, University of Basel, Basel (Switzerland); Institute for Theoretical Physics, ETH Zürich, Zürich (Switzerland); Loss, Daniel [CEMS, RIKEN, Wako, Saitama 351-0198 (Japan); Department of Physics, University of Basel, Basel (Switzerland); Pedrocchi, Fabio L. [Department of Physics, University of Basel, Basel (Switzerland)
2013-11-15
We investigate the role that vortex loops play in characterizing eigenstates of interacting Majoranas. We give some general results and then focus on ladder Hamiltonian examples as a test of further ideas. Two methods yield exact results: (i) A mapping of certain spin Hamiltonians to quartic interactions of Majoranas shows that the spectra of these two examples coincide. (ii) In cases with reflection-symmetric Hamiltonians, we use reflection positivity for Majoranas to characterize vortices in the ground states. Two additional methods suggest wider applicability of these results: (iii) Numerical evidence suggests similar behavior for certain systems without reflection symmetry. (iv) A perturbative analysis also suggests similar behavior without the assumption of reflection symmetry.
Rovelli Carlo
2008-07-01
Full Text Available The problem of describing the quantum behavior of gravity, and thus understanding quantum spacetime, is still open. Loop quantum gravity is a well-developed approach to this problem. It is a mathematically well-defined background-independent quantization of general relativity, with its conventional matter couplings. Today research in loop quantum gravity forms a vast area, ranging from mathematical foundations to physical applications. Among the most significant results obtained so far are: (i The computation of the spectra of geometrical quantities such as area and volume, which yield tentative quantitative predictions for Planck-scale physics. (ii A physical picture of the microstructure of quantum spacetime, characterized by Planck-scale discreteness. Discreteness emerges as a standard quantum effect from the discrete spectra, and provides a mathematical realization of Wheeler’s “spacetime foam” intuition. (iii Control of spacetime singularities, such as those in the interior of black holes and the cosmological one. This, in particular, has opened up the possibility of a theoretical investigation into the very early universe and the spacetime regions beyond the Big Bang. (iv A derivation of the Bekenstein–Hawking black-hole entropy. (v Low-energy calculations, yielding n-point functions well defined in a background-independent context. The theory is at the roots of, or strictly related to, a number of formalisms that have been developed for describing background-independent quantum field theory, such as spin foams, group field theory, causal spin networks, and others. I give here a general overview of ideas, techniques, results and open problems of this candidate theory of quantum gravity, and a guide to the relevant literature.
Concentration and length dependence of DNA looping in transcriptional regulation.
Lin Han
Full Text Available In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest. This action at a distance is often mediated by the formation of DNA loops: Binding at two or more sites on the DNA results in the formation of a loop, which can bring the transcription factor into the immediate neighborhood of the relevant promoter. These processes are important in settings ranging from the historic bacterial examples (bacterial metabolism and the lytic-lysogeny decision in bacteriophage, to the modern concept of gene regulation to regulatory processes central to pattern formation during development of multicellular organisms. Though there have been a variety of insights into the combinatorial aspects of transcriptional control, the mechanism of DNA looping as an agent of combinatorial control in both prokaryotes and eukaryotes remains unclear. We use single-molecule techniques to dissect DNA looping in the lac operon. In particular, we measure the propensity for DNA looping by the Lac repressor as a function of the concentration of repressor protein and as a function of the distance between repressor binding sites. As with earlier single-molecule studies, we find (at least two distinct looped states and demonstrate that the presence of these two states depends both upon the concentration of repressor protein and the distance between the two repressor binding sites. We find that loops form even at interoperator spacings considerably shorter than the DNA persistence length, without the intervention of any other proteins to prebend the DNA. The concentration measurements also permit us to use a simple statistical mechanical model of DNA loop formation to determine the free energy of DNA looping, or equivalently, the for looping.
Leptogenesis from loop effects in curved spacetime
McDonald, Jamie I
2015-01-01
We describe a new mechanism -- radiatively-induced gravitational leptogenesis -- for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrat...
Factorized soft graviton theorems at loop level
Broedel, Johannes; Plefka, Jan; Rosso, Matteo
2014-01-01
We analyze the low-energy behavior of scattering amplitudes involving gravitons at loop level in four dimensions. The single-graviton soft limit is controlled by soft operators which have been argued to separate into a factorized piece and a non-factorizing infrared divergent contribution. In this note we show that the soft operators responsible for the factorized contributions are strongly constrained by gauge and Poincare invariance under the assumption of a local structure. We show that the leading and subleading orders in the soft-momentum expansion can not receive radiative corrections. The first radiative correction occurs for the sub-subleading soft graviton operator and is one-loop exact. It depends on only two undetermined coefficients which should reflect the field content of the theory under consideration.
Phenomenology of loop quantum cosmology
Sakellariadou, Mairi
2010-01-01
After introducing the basic ingredients of Loop Quantum Cosmology, I will briefly discuss some of its phenomenological aspects. Those can give some useful insight about the full Loop Quantum Gravity theory and provide an answer to some long-standing questions in early universe cosmology.
RCD+: Fast loop modeling server.
López-Blanco, José Ramón; Canosa-Valls, Alejandro Jesús; Li, Yaohang; Chacón, Pablo
2016-07-08
Modeling loops is a critical and challenging step in protein modeling and prediction. We have developed a quick online service (http://rcd.chaconlab.org) for ab initio loop modeling combining a coarse-grained conformational search with a full-atom refinement. Our original Random Coordinate Descent (RCD) loop closure algorithm has been greatly improved to enrich the sampling distribution towards near-native conformations. These improvements include a new workflow optimization, MPI-parallelization and fast backbone angle sampling based on neighbor-dependent Ramachandran probability distributions. The server starts by efficiently searching the vast conformational space from only the loop sequence information and the environment atomic coordinates. The generated closed loop models are subsequently ranked using a fast distance-orientation dependent energy filter. Top ranked loops are refined with the Rosetta energy function to obtain accurate all-atom predictions that can be interactively inspected in an user-friendly web interface. Using standard benchmarks, the average root mean squared deviation (RMSD) is 0.8 and 1.4 Å for 8 and 12 residues loops, respectively, in the challenging modeling scenario in where the side chains of the loop environment are fully remodeled. These results are not only very competitive compared to those obtained with public state of the art methods, but also they are obtained ∼10-fold faster. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
Laflame, D. T.
1980-01-01
Delay-locked loop tracks pseudonoise codes without introducing dc timing errors, because it is not sensitive to gain imbalance between signal processing arms. "Early" and "late" reference codes pass in combined form through both arms, and each arm acts on both codes. Circuit accomodates 1 dB weaker input signals with tracking ability equal to that of tau-dither loops.
Loop groups and noncommutative geometry
Carpi, Sebastiano
2015-01-01
We describe the representation theory of loop groups in terms of K-theory and noncommutative geometry. This is done by constructing suitable spectral triples associated with the level l projective unitary positive-energy representations of any given loop group LG. The construction is based on certain supersymmetric conformal field theory models associated with LG.
Brane Couplings from Bulk Loops
Georgi, Howard; Grant, Aaron K.; Hailu, Girma
2000-01-01
We compute loop corrections to the effective action of a field theory on a five-dimensional $S_1/Z_2$ orbifold. We find that the quantum loop effects of interactions in the bulk produce infinite contributions that require renormalization by four-dimensional couplings on the orbifold fixed planes. Thus bulk couplings give rise to renormalization group running of brane couplings.
Higher dimensional loop quantum cosmology
Zhang, Xiangdong
2016-07-01
Loop quantum cosmology (LQC) is the symmetric sector of loop quantum gravity. In this paper, we generalize the structure of loop quantum cosmology to the theories with arbitrary spacetime dimensions. The isotropic and homogeneous cosmological model in n+1 dimensions is quantized by the loop quantization method. Interestingly, we find that the underlying quantum theories are divided into two qualitatively different sectors according to spacetime dimensions. The effective Hamiltonian and modified dynamical equations of n+1 dimensional LQC are obtained. Moreover, our results indicate that the classical big bang singularity is resolved in arbitrary spacetime dimensions by a quantum bounce. We also briefly discuss the similarities and differences between the n+1 dimensional model and the 3+1 dimensional one. Our model serves as a first example of higher dimensional loop quantum cosmology and offers the possibility to investigate quantum gravity effects in higher dimensional cosmology.
R Loops in the Regulation of Antibody Gene Diversification.
Pavri, Rushad
2017-06-02
For nearly three decades, R loops have been closely linked with class switch recombination (CSR), the process that generates antibody isotypes and that occurs via a complex cascade initiated by transcription-coupled mutagenesis in switch recombination sequences. R loops form during transcription of switch recombination sequences in vitro and in vivo, and there is solid evidence that R loops are required for efficient class switching. The classical model of R loops posits that they boost mutation rates by generating stable and long tracts of single-stranded DNA that serve as the substrate for activation induced deaminase (AID), the enzyme that initiates the CSR reaction cascade by co-transcriptionally mutating ssDNA in switch recombination sequences. Though logical and compelling, this model has not been supported by in vivo evidence. Indeed, several reports suggest that R loops may not be involved in recruiting AID activity to switch regions, meaning that R loops probably serve other unanticipated roles in CSR. Here, I review the key findings in this field to date and propose hypotheses that could help towards elucidating the precise function of R loops in CSR.
Chirikjian, Gregory S
2011-01-01
Proteins fold from a highly disordered state into a highly ordered one. Traditionally, the folding problem has been stated as one of predicting "the" tertiary structure from sequential information. However, new evidence suggests that the ensemble of unfolded forms may not be as disordered as once believed, and that the native form of many proteins may not be described by a single conformation, but rather an ensemble of its own. Quantifying the relative disorder in the folded and unfolded ensembles as an entropy difference may therefore shed light on the folding process. One issue that clouds discussions of "entropy" is that many different kinds of entropy can be defined: entropy associated with overall translational and rotational Brownian motion, configurational entropy, vibrational entropy, conformational entropy computed in internal or Cartesian coordinates (which can even be different from each other), conformational entropy computed on a lattice, each of the above with different solvation and solvent models, thermodynamic entropy measured experimentally, etc. The focus of this work is the conformational entropy of coil/loop regions in proteins. New mathematical modeling tools for the approximation of changes in conformational entropy during transition from unfolded to folded ensembles are introduced. In particular, models for computing lower and upper bounds on entropy for polymer models of polypeptide coils both with and without end constraints are presented. The methods reviewed here include kinematics (the mathematics of rigid-body motions), classical statistical mechanics, and information theory.
Freidel, Laurent; Pranzetti, Daniele
2016-01-01
In this work we study canonical gravity in finite regions for which we introduce a generalisation of the Gibbons-Hawking boundary term including the Immirzi parameter. We study the canonical formulation on a spacelike hypersuface with a boundary sphere and show how the presence of this term leads to an unprecedented type of degrees of freedom coming from the restoration of the gauge and diffeomorphism symmetry at the boundary. In the presence of a loop quantum gravity state, these boundary degrees of freedom localize along a set of punctures on the boundary sphere. We demonstrate that these degrees of freedom are effectively described by auxiliary strings with a 3-dimensional internal target space attached to each puncture. We show that the string currents represent the local frame field, that the string angular momenta represent the area flux and that the string stress tensor represents the two dimensional metric on the boundary of the region of interest. Finally, we show that the commutators of these broken...
The modified Altemeier procedure for a loop colostomy prolapse.
Watanabe, Makoto; Murakami, Masahiko; Ozawa, Yoshiaki; Uchida, Marie; Yamazaki, Kimiyasu; Fujimori, Akira; Otsuka, Koji; Aoki, Takeshi
2015-11-01
Loop colostomy prolapse is associated with an impaired quality of life. Surgical treatment may sometimes be required for cases that cannot be closed by colon colostomy because of high-risk morbidities or advanced disease. We applied the Altimeter operation for patients with transverse loop colostomy. The Altemeier operation is therefore indicated for rectal prolapse. This technique involves a simple operation, which includes a circumferential incision through the full thickness of the outer and inner cylinder of the prolapsed limb, without incising the abdominal wall, and anastomosis with sutures using absorbable thread. We performed the Altemeier operation for three cases of loop stomal prolapse. Those patients demonstrated no postoperative complications (including obstruction, prolapse recurrence, or hernia). Our findings suggest that this procedure is useful as an optional surgical treatment for cases of transverse loop colostomy prolapse as a permanent measure in patients with high-risk morbidities or advanced disease.
Radial propagators and Wilson loops
Leupold, S; Leupold, Stefan; Weigert, Heribert
1996-01-01
We present a relation which connects the propagator in the radial (Fock-Schwinger) gauge with a gauge invariant Wilson loop. It is closely related to the well-known field strength formula and can be used to calculate the radial gauge propagator. The result is shown to diverge in four-dimensional space even for free fields, its singular nature is however naturally explained using the renormalization properties of Wilson loops with cusps and self-intersections. Using this observation we provide a consistent regularization scheme to facilitate loop calculations. Finally we compare our results with previous approaches to derive a propagator in Fock-Schwinger gauge.
Mining protein loops using a structural alphabet and statistical exceptionality
Martin Juliette
2010-02-01
Full Text Available Abstract Background Protein loops encompass 50% of protein residues in available three-dimensional structures. These regions are often involved in protein functions, e.g. binding site, catalytic pocket... However, the description of protein loops with conventional tools is an uneasy task. Regular secondary structures, helices and strands, have been widely studied whereas loops, because they are highly variable in terms of sequence and structure, are difficult to analyze. Due to data sparsity, long loops have rarely been systematically studied. Results We developed a simple and accurate method that allows the description and analysis of the structures of short and long loops using structural motifs without restriction on loop length. This method is based on the structural alphabet HMM-SA. HMM-SA allows the simplification of a three-dimensional protein structure into a one-dimensional string of states, where each state is a four-residue prototype fragment, called structural letter. The difficult task of the structural grouping of huge data sets is thus easily accomplished by handling structural letter strings as in conventional protein sequence analysis. We systematically extracted all seven-residue fragments in a bank of 93000 protein loops and grouped them according to the structural-letter sequence, named structural word. This approach permits a systematic analysis of loops of all sizes since we consider the structural motifs of seven residues rather than complete loops. We focused the analysis on highly recurrent words of loops (observed more than 30 times. Our study reveals that 73% of loop-lengths are covered by only 3310 highly recurrent structural words out of 28274 observed words. These structural words have low structural variability (mean RMSd of 0.85 Å. As expected, half of these motifs display a flanking-region preference but interestingly, two thirds are shared by short (less than 12 residues and long loops. Moreover, half of
Leptogenesis from loop effects in curved spacetime
McDonald, Jamie I.; Shore, Graham M.
2016-04-01
We describe a new mechanism — radiatively-induced gravitational leptogenesis — for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrate by explicit computation of the relevant two-loop Feynman diagrams how the size of the radiative corrections relevant for leptogenesis becomes enhanced by increasing the mass hierarchy of the sterile neutrinos, and show how the induced lepton asymmetry may be sufficiently large to play an important rôle in determining the baryon-to-photon ratio of the Universe.
Leptogenesis from loop effects in curved spacetime
McDonald, Jamie I.; Shore, Graham M. [Department of Physics, Swansea University,Singleton Park, Swansea, SA2 8PP (United Kingdom)
2016-04-05
We describe a new mechanism — radiatively-induced gravitational leptogenesis — for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrate by explicit computation of the relevant two-loop Feynman diagrams how the size of the radiative corrections relevant for leptogenesis becomes enhanced by increasing the mass hierarchy of the sterile neutrinos, and show how the induced lepton asymmetry may be sufficiently large to play an important rôle in determining the baryon-to-photon ratio of the Universe.
Kurz, Alexander; Liu, Tao; Marquard, Peter; Steinhauser, Matthias [Institut fuer Theoretische Teilchenphysik, Karlsruhe (Germany)
2013-07-01
We present results for the QED contribution from a heavy lepton loop to the anomalous magnetic moment of the muon and the electron. Exploiting the strong hierarchy between the tau, muon and electron masses (m{sub τ} >>m{sub μ} >>m{sub e}), we use the method of asymptotic expansion which leads to on-shell and vacuum integrals up to three and four loops, respectively. Analytic results are presented up to four loops for the muon anomalous moment involving virtual τ-lepton loops and for the electron magnetic moment involving τ- and μ-lepton loops.
Product Integrals and Wilson loops
Karp, R L
2001-01-01
Using product integrals we review the unambiguous mathematical representation of Wilson line and Wilson loop operators, including their behavior under gauge transformations and the non-abelian Stokes theorem. Interesting consistency conditions among Wilson lines are also presented.
Thermal fluctuations in loop cosmology
Magueijo, J; Magueijo, Joao; Singh, Parampreet
2007-01-01
Quantum gravitational effects in loop quantum cosmology lead to a resolution of the initial singularity and have the potential to solve the horizon problem and generate a quasi scale-invariant spectrum of density fluctuations. We consider loop modifications to the behavior of the inverse scale factor below a critical scale in closed models and assume a purely thermal origin for the fluctuations. We show that the no-go results for scale invariance in classical thermal models can be evaded even if we just consider modifications to the background (zeroth order) gravitational dynamics. Since a complete and systematic treatment of the perturbed Einstein equations in loop cosmology is still lacking, we simply parameterize their expected modifications. These change quantitatively, but not qualitatively, our conclusions. We thus urge the community to more fully work out this complex aspect of loop cosmology, since the full picture would not only fix the free parameters of the theory, but also provide a model for a no...
Loop Quantum Cosmology Gravitational Baryogenesis
Odintsov, S D
2016-01-01
Loop Quantum Cosmology is an appealing quantum completion of classical cosmology, which brings along various theoretical features which in many cases offer remedy or modify various classical cosmology aspects. In this paper we address the gravitational baryogenesis mechanism in the context of Loop Quantum Cosmology. As we demonstrate, when Loop Quantum Cosmology effects are taken into account in the resulting Friedmann equations for a flat Friedmann-Robertson-Walker Universe, then even for a radiation dominated Universe, the predicted baryon-to-entropy ratio from the gravitational baryogenesis mechanism is non-zero, in contrast to the Einstein-Hilbert case, in which case the baryon-to-entropy ratio is zero. We also discuss various other cases apart from the radiation domination case, and we discuss how the baryon-to-entropy ratio is affected from the parameters of the quantum theory. In addition, we use illustrative exact solutions of Loop Quantum Cosmology and we investigate under which circumstances the bar...
Continuous smearing of Wilson Loops
Lohmayer, Robert
2011-01-01
Continuum smearing was introduced in section 4.1 of JHEP03, 064 (2006) as a meaningful continuum analogue of the well known set of lattice techniques by the same name. Here we apply continuous smearing in continuous space-time to Wilson loops in order to clarify what it does in the context of field theory and also in the context of the loop calculus of the Makeenko-Migdal equation.
The Projectile inside the Loop
Varieschi, Gabriele U.
2005-01-01
In this paper we describe an alternative use of the loop-the-loop apparatus, which can be used to study an interesting case of projectile motion. We also present an effective way to perform and analyze these experiments, by using video capture software together with a digital video camera. These experiments can be integrated into classroom demonstrations for general physics courses, or become part of laboratory activities.
Introduction to Loop Quantum Gravity
Mercuri, Simone
2010-01-01
The questions I have been asked during the 5th International School on Field Theory and Gravitation, have compelled me to give an account of the premises that I consider important for a beginner's approach to Loop Quantum Gravity. After a description of some general arguments and an introduction to the canonical theory of gravity, I review the background independent approach to quantum gravity, giving only a brief survey of Loop Quantum Gravity.
Bifurcations of nontwisted heteroclinic loop
田清平; 朱德明
2000-01-01
Bifurcations of nontwisted and fine heteroclinic loops are studied for higher dimensional systems. The existence and its associated existing regions are given for the 1-hom orbit and the 1-per orbit, respectively, and bifurcation surfaces of the two-fold periodic orbit are also obtained. At last, these bifurcation results are applied to the fine heteroclinic loop for the planar system, which leads to some new and interesting results.
Antoni Hermoso
2007-01-01
Full Text Available Loops represent an important part of protein structures. The study of loop is critical for two main reasons: First, loops are often involved in protein function, stability and folding. Second, despite improvements in experimental and computational structure prediction methods, modeling the conformation of loops remains problematic. Here, we present a structural classification of loops, ArchDB, a mine of information with application in both mentioned fields: loop structure prediction and function prediction. ArchDB (http://sbi.imim.es/archdb is a database of classified protein loop motifs. The current database provides four different classification sets tailored for different purposes. ArchDB-40, a loop classification derived from SCOP40, well suited for modeling common loop motifs. Since features relevant to loop structure or function can be more easily determined on well-populated clusters, we have developed ArchDB-95, a loop classification derived from SCOP95. This new classification set shows a ∼40% increase in the number of subclasses, and a large 7-fold increase in the number of putative structure/function-related subclasses. We also present ArchDB-EC, a classification of loop motifs from enzymes, and ArchDB-KI, a manually annotated classification of loop motifs from kinases. Information about ligand contacts and PDB sites has been included in all classification sets. Improvements in our classification scheme are described, as well as several new database features, such as the ability to query by conserved annotations, sequence similarity, or uploading 3D coordinates of a protein. The lengths of classified loops range between 0 and 36 residues long. ArchDB offers an exhaustive sampling of loop structures. Functional information about loops and links with related biological databases are also provided. All this information and the possibility to browse/query the database through a web-server outline an useful tool with application in the
Fast-sausage oscillations in coronal loops with smooth boundary
Lopin, I.; Nagorny, I.
2014-12-01
Aims: The effect of the transition layer (shell) in nonuniform coronal loops with a continuous radial density profile on the properties of fast-sausage modes are studied analytically and numerically. Methods: We modeled the coronal waveguide as a structured tube consisting of a cord and a transition region (shell) embedded within a magnetic uniform environment. The derived general dispersion relation was investigated analytically and numerically in the context of frequency, cut-off wave number, and the damping rate of fast-sausage oscillations for various values of loop parameters. Results: The frequency of the global fast-sausage mode in the loops with a diffuse (or smooth) boundary is determined mainly by the external Alfvén speed and longitudinal wave number. The damping rate of such a mode can be relatively low. The model of coronal loop with diffuse boundary can support a comparatively low-frequency, global fast-sausage mode of detectable quality without involving extremely low values of the density contrast. The effect of thin transition layer (corresponds to the loops with steep boundary) is negligible and produces small reductions of oscillation frequency and relative damping rate in comparison with the case of step-function density profile. Seismological application of obtained results gives the estimated Alfvén speed outside the flaring loop about 3.25 Mm/s.
Solving the puzzle of interstitial loop formation in bcc Iron.
Xu, Haixuan; Stoller, Roger E; Osetsky, Yury N; Terentyev, Dmitry
2013-06-28
The interstitial loop is a unique signature of radiation damage in structural materials for nuclear and other advanced energy systems. Unlike other bcc metals, two types of interstitial loops, 1/2 and , are formed in bcc iron and its alloys. However, the mechanism by which interstitial dislocation loops are formed has remained undetermined since they were first observed more than fifty years ago. We describe our atomistic simulations that have provided the first direct observation of loop formation. The process was initially observed using our self-evolving atomistic kinetic Monte Carlo method, and subsequently confirmed using molecular dynamics simulations. Formation of loops involves a distinctly atomistic interaction between two 1/2 loops, and does not follow the conventional assumption of dislocation theory, which is Burgers vector conservation between the reactants and the product. The process observed is different from all previously proposed mechanisms. Thus, our observations might provide a direct link between experiments and simulations and new insights into defect formation that may provide a basis to increase the radiation resistance of these strategic materials.
Bol loops of odd prime exponent
Foguel, Tuval
2009-01-01
Although any finite Bol loop of odd prime exponent is solvable, we show there exist such Bol loops with trivial center. We also construct finitely generated, infinite, simple Bruck loops of odd prime exponent for sufficiently large primes. This shows that the Burnside problem for Bruck loops has a negative answer.
Classifying Finitely Generated Indecomposable RA Loops
Cornelissen, Mariana
2012-01-01
In 1995, E. Jespers, G. Leal and C. Polcino Milies classified all finite ring alternative loops (RA loops for short) which are not direct products of proper subloops. In this paper we extend this result to finitely generated RA loops and provide an explicit description of all such loops.
Kalman Orbit Optimized Loop Tracking
Young, Lawrence E.; Meehan, Thomas K.
2011-01-01
Under certain conditions of low signal power and/or high noise, there is insufficient signal to noise ratio (SNR) to close tracking loops with individual signals on orbiting Global Navigation Satellite System (GNSS) receivers. In addition, the processing power available from flight computers is not great enough to implement a conventional ultra-tight coupling tracking loop. This work provides a method to track GNSS signals at very low SNR without the penalty of requiring very high processor throughput to calculate the loop parameters. The Kalman Orbit-Optimized Loop (KOOL) tracking approach constitutes a filter with a dynamic model and using the aggregate of information from all tracked GNSS signals to close the tracking loop for each signal. For applications where there is not a good dynamic model, such as very low orbits where atmospheric drag models may not be adequate to achieve the required accuracy, aiding from an IMU (inertial measurement unit) or other sensor will be added. The KOOL approach is based on research JPL has done to allow signal recovery from weak and scintillating signals observed during the use of GPS signals for limb sounding of the Earth s atmosphere. That approach uses the onboard PVT (position, velocity, time) solution to generate predictions for the range, range rate, and acceleration of the low-SNR signal. The low- SNR signal data are captured by a directed open loop. KOOL builds on the previous open loop tracking by including feedback and observable generation from the weak-signal channels so that the MSR receiver will continue to track and provide PVT, range, and Doppler data, even when all channels have low SNR.
Study of the Open Loop and Closed Loop Oscillator Techniques
Imel, George R. [Idaho State Univ., Pocatello, ID (United States); Baker, Benjamin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Riley, Tony [Knolls Atomic Power Lab. (KAPL), Schenectady, NY (United States); Langbehn, Adam [Puget Sound Naval Base, Bremerton, WA (United States); Aryal, Harishchandra [Idaho State Univ., Pocatello, ID (United States); Benzerga, M. Lamine [Idaho State Univ., Pocatello, ID (United States)
2015-04-11
This report presents the progress and completion of a five-year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques.The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this report we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems.
BPS Wilson Loops on S^2 at Higher Loops
Young, Donovan
2008-01-01
We consider supersymmetric Wilson loops of the variety constructed by Drukker, Giombi, Ricci, and Trancanelli, whose spatial contours lie on a two-sphere. Working to second order in the 't Hooft coupling in planar N=4 Supersymmetric Yang-Mills Theory (SYM), we compute the vacuum expectation value of a wavy-latitude and of a loop composed of two longitudes. We evaluate the resulting integrals numerically and find that the results are consistent with the zero-instanton sector calculation of Wilson loops in 2-d Yang-Mills on S^2 performed by Bassetto and Griguolo. We also consider the connected correlator of two distinct latitudes to third order in the 't Hooft coupling in planar N=4 SYM. We compare the result in the limit where the latitudes become coincident to a perturbative calculation in 2-d Yang-Mills on S^2 using a light-cone Wu-Mandelstam-Leibbrandt prescription. The two calculations produce differing results.
Eigenvalue distributions of Wilson loops
Lohmayer, Robert
2010-07-01
In the first part of this thesis, we focus on the distribution of the eigenvalues of the unitary Wilson loop matrix in the two-dimensional case at arbitrary finite N. To characterize the distribution of the eigenvalues, we introduce three density functions (the ''symmetric'', the ''antisymmetric'', and the ''true'' eigenvalue density) which differ at finite N but possess the same infinite-N limit, exhibiting the Durhuus-Olesen phase transition. Using expansions of determinants and inverse determinants in characters of totally symmetric or totally antisymmetric representations of SU(N), the densities at finite N can be expressed in terms of simple sums involving only dimensions and quadratic Casimir invariants of certain irreducible representations of SU(N), allowing for a numerical computation of the densities at arbitrary N to any desired accuracy. We find that the true eigenvalue density, adding N oscillations to the monotonic symmetric density, is in some sense intermediate between the symmetric and the antisymmetric density, which in turn is given by a sum of N delta peaks located at the zeros of the average of the characteristic polynomial. Furthermore, we show that the dependence on N can be made explicit by deriving integral representations for the resolvents associated to the three eigenvalue densities. Using saddle-point approximations, we confirm that all three densities reduce to the Durhuus-Olesen result in the infinite-N limit. In the second part, we study an exponential form of the multiplicative random complex matrix model introduced by Gudowska-Nowak et al. Varying a parameter which can be identified with the area of the Wilson loop in the unitary case, the region of non-vanishing eigenvalue density of the N-dimensional complex product matrix undergoes a topological change at a transition point in the infinite-N limit. We study the transition by a detailed analysis of the average of the
A Role for the Cytoskeleton in Heart Looping
Kersti K. Linask
2007-01-01
Full Text Available Over the past 10 years, key genes involved in specification of left-right laterality pathways in the embryo have been defined. The read-out for misexpression of laterality genes is usually the direction of heart looping. The question of how dextral looping direction occurred mechanistically and how the heart tube bends remains unknown. It is becoming clear from our experiments and those of others that left-right differences in cell proliferation in the second heart field (anterior heart field drives the dextral direction. Evidence is accumulating that the cytoskeleton is at the center of laterality, and the bending and rotational forces associated with heart looping. If laterality pathways are modulated upstream, the cytoskeleton, including nonmuscle myosin II (NMHC-II, is altered downstream within the cardiomyocytes, leading to looping abnormalities. The cytoskeleton is associated with important mechanosensing and signaling pathways in cell biology and development. The initiation of blood flow during the looping period and the inherent stresses associated with increasing volumes of blood flowing into the heart may help to potentiate the process. In recent years, the steps involved in this central and complex process of heart development that is the basis of numerous congenital heart defects are being unraveled.
Automation of one-loop calculations with GoSam
Soden-Fraunhofen, Johann Felix von [Max-Planck-Institut fuer Physik, Muenchen (Germany)
2012-07-01
The program package GoSam can be used to calculate multi-leg one-loop amplitudes within and beyond the Standard Model. An extension is additionally presented which allows to calculate integrals where the rank is larger than the number of propagators. One possible application of this feature is the calculation of QCD corrections within models involving extra dimensions.
Closed Loop Requirements and Analysis Management
Lamoreaux, Michael; Verhoef, Brett
2015-01-01
Effective systems engineering involves the use of analysis in the derivation of requirements and verification of designs against those requirements. The initial development of requirements often depends on analysis for the technical definition of specific aspects of a product. Following the allocation of system-level requirements to a product's components, the closure of those requirements often involves analytical approaches to verify that the requirement criteria have been satisfied. Meanwhile, changes that occur in between these two processes need to be managed in order to achieve a closed-loop requirement derivation/verification process. Herein are presented concepts for employing emerging Team center capabilities to jointly manage requirements and analysis data such that analytical techniques are utilized to effectively derive and allocate requirements, analyses are consulted and updated during the change evaluation processes, and analyses are leveraged during the design verification process. Recommendations on concept validation case studies are also discussed.
Generalized loop space and TMDs
Mertens Tom
2014-06-01
Full Text Available The Standard Model describes the three (of four basic interactions known in Nature in terms of the quantum fields which are constituted by representations of special unitary gauge groups of symmetry. However, the physical observables do not always coincide with the fundamental degrees of freedom of the Standard Model. Therefore it can be useful to switch to the loop space representation of the gauge theory, where the variables are inherently gauge invariant but the degrees of freedom are absorbed in the path/loop dependence. Over-completeness of this space requires the introduction of an equivalence relation which is provided by Wilson loop functionals operating on piecewise regular paths. It is well known that certain Wilson loops show the same singularity structure as some Transverse Momentum Dependent PDFs (TMDs, which are not renormalizable by the common methods due to exactly this singularity structure. By introducing geometrical operators, like the area-derivative, we were able to derive an evolution equation for these Wilson loops and we hope to apply this method in the future to find some renormalization schemes for TMDs.
Loop coupled resonator optical waveguides.
Song, Junfeng; Luo, Lian-Wee; Luo, Xianshu; Zhou, Haifeng; Tu, Xiaoguang; Jia, Lianxi; Fang, Qing; Lo, Guo-Qiang
2014-10-06
We propose a novel coupled resonator optical waveguide (CROW) structure that is made up of a waveguide loop. We theoretically investigate the forbidden band and conduction band conditions in an infinite periodic lattice. We also discuss the reflection- and transmission- spectra, group delay in finite periodic structures. Light has a larger group delay at the band edge in a periodic structure. The flat band pass filter and flat-top group delay can be realized in a non-periodic structure. Scattering matrix method is used to calculate the effects of waveguide loss on the optical characteristics of these structures. We also introduce a tunable coupling loop waveguide to compensate for the fabrication variations since the coupling coefficient of the directional coupler in the loop waveguide is a critical factor in determining the characteristics of a loop CROW. The loop CROW structure is suitable for a wide range of applications such as band pass filters, high Q microcavity, and optical buffers and so on.
Position-space renormalization of the self-avoiding loop gas on the square lattice
Biedermann, K. H.; Helfrich, W.
1983-06-01
We propose a general method to renormalize statistical collections of loops on a lattice. It employs the ratio of the statistical weights of different “macroconfigurations”. A calculation involving up to 4 × 4 unit cells yields ν ≈ 1.04 for non-intersecting loops of multiplicity one on the square lattice.
Vertically Polarized Omnidirectional Printed Slot Loop AntennaPrinted Slot Loop Antenna (invited)
Kammersgaard, Nikolaj Peter Iversen; Kvist, Søren Helstrup; Thaysen, Jesper
2015-01-01
A novel verticall A novel vertically polarized dpolarize , omnidirection omnidirectional l , printed slot loop antenna h sprinted slot loop antenna has been designed, simulated, fabricated, and measured. The slot loop works as a magnetic loop. The loop is loaded with inductors to insure uniform...
All digital pulsewidth control loop
Huang, Hong-Yi; Jan, Shiun-Dian; Pu, Ruei-Iun
2013-03-01
This work presents an all-digital pulsewidth control loop (ADPWCL). The proposed system accepts a wide range of input duty cycles and performs a fast correction to the target output pulsewidth. An all-digital delay-locked loop (DLL) with fast locking time using a simplified time to digital converter and a new differential two-step delay element is proposed. The area of the delay element is much smaller than that in conventional designs, while having the same delay range. A test chip is verified in a 0.18-µm CMOS process. The measured duty cycle ranges from 4% to 98% with 7-bit resolution.
Loop quantum cosmology: Recent progress
Martin Bojowald
2004-10-01
Aspects of the full theory of loop quantum gravity can be studied in a simpler context by reducing to symmetric models like cosmological ones. This leads to several applications where loop effects play a significant role when one is sensitive to the quantum regime. As a consequence, the structure of and the approach to classical singularities are very different from general relativity. The quantum theory is free of singularities, and there are new phenomenological scenarios for the evolution of the very early universe such as inflation. We give an overview of the main effects, focussing on recent results obtained by different groups.
Loop quantum geometry: a primer
Corichi, Alejandro [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, A. Postal 70-543, Mexico D.F. 04510 (Mexico)
2005-01-15
This is the written version of a lecture given at the 'VI Mexican School of Gravitation and Mathematical Physics' (Nov 21-27, 2004, Playa del Carmen, Mexico), introducing the basics of Loop Quantum Geometry. The purpose of the written contribution is to provide a Primer version, that is, a first entry into Loop Quantum Gravity and to present at the same time a friendly guide to the existing pedagogical literature on the subject. This account is geared towards graduate students and non-experts interested in learning the basics of the subject.
LISA Pathfinder: OPD loop characterisation
Born, Michael; LPF Collaboration
2017-05-01
The optical metrology system (OMS) of the LISA Pathfinder mission is measuring the distance between two free-floating test masses with unprecedented precision. One of the four OMS heterodyne interferometers reads out the phase difference between the reference and the measurement laser beam. This phase from the reference interferometer is common to all other longitudinal interferometer read outs and therefore subtracted. In addition, the phase is fed back via the digital optical pathlength difference (OPD) control loop to keep it close to zero. Here, we analyse the loop parameters and compare them to on-ground measurement results.
Loop Quantum Geometry: A primer
Corichi, Alejandro
2005-01-01
This is the written version of a lecture given at the ``VI Mexican School of Gravitation and Mathematical Physics" (Nov 21-27, 2004, Playa del Carmen, Mexico), introducing the basics of Loop Quantum Geometry. The purpose of the written contribution is to provide a Primer version, that is, a first entry into Loop Quantum Gravity and to present at the same time a friendly guide to the existing pedagogical literature on the subject. This account is geared towards graduate students and non-expert...
Ezra S Simon
2008-01-01
This study was conducted in Ghana to investigate, (1) factors that predict parental involvement, (2) the relationship between parental home and school involvement and the educational achievement of adolescents, (3) the relationship between parental authoritativeness and the educational achievement of adolescent students, (4) parental involvement serving as a mediator between their authoritativeness and the educational achievement of the students, and (5) whether parental involvement decreases...
Chemical-Looping Combustion and Gasification of Coals and Oxygen Carrier Development: A Brief Review
Ping Wang
2015-09-01
Full Text Available Chemical-looping technology is one of the promising CO2 capture technologies. It generates a CO2 enriched flue gas, which will greatly benefit CO2 capture, utilization or sequestration. Both chemical-looping combustion (CLC and chemical-looping gasification (CLG have the potential to be used to generate power, chemicals, and liquid fuels. Chemical-looping is an oxygen transporting process using oxygen carriers. Recently, attention has focused on solid fuels such as coal. Coal chemical-looping reactions are more complicated than gaseous fuels due to coal properties (like mineral matter and the complex reaction pathways involving solid fuels. The mineral matter/ash and sulfur in coal may affect the activity of oxygen carriers. Oxygen carriers are the key issue in chemical-looping processes. Thermogravimetric analysis (TGA has been widely used for the development of oxygen carriers (e.g., oxide reactivity. Two proposed processes for the CLC of solid fuels are in-situ Gasification Chemical-Looping Combustion (iG-CLC and Chemical-Looping with Oxygen Uncoupling (CLOU. The objectives of this review are to discuss various chemical-looping processes with coal, summarize TGA applications in oxygen carrier development, and outline the major challenges associated with coal chemical-looping in iG-CLC and CLOU.
Electrical conductivity measurements on silicate melts using the loop technique
Waff, H. S.
1976-01-01
A new method is described for measurement of the electrical conductivity of silicate melts under controlled oxygen partial pressure at temperatures to 1550 C. The melt samples are suspended as droplets on platinum-rhodium loops, minimizing iron loss from the melt due to alloying with platinum, and providing maximum surface exposure of the melt to the oxygen-buffering gas atmosphere. The latter provides extremely rapid equilibration of the melt with the imposed oxygen partial pressure. The loop technique involves a minimum of setup time and cost, provides reproducible results to within + or - 5% and is well suited to electrical conductivity studies on silicate melts containing redox cations.
Stem-loop structures in prokaryotic genomes
Boccia Angelo
2006-07-01
Full Text Available Abstract Background Prediction of secondary structures in the expressed sequences of bacterial genomes allows to investigate spontaneous folding of the corresponding RNA. This is particularly relevant in untranslated mRNA regions, where base pairing is less affected by interactions with the translation machinery. Relatively large stem-loops significantly contribute to the formation of more complex secondary structures, often important for the activity of sequence elements controlling gene expression. Results Systematic analysis of the distribution of stem-loop structures (SLSs in 40 wholly-sequenced bacterial genomes is presented. SLSs were searched as stems measuring at least 12 bp, bordering loops 5 to 100 nt in length. G-U pairing in the stems was allowed. SLSs found in natural genomes are constantly more numerous and stable than those expected to randomly form in sequences of comparable size and composition. The large majority of SLSs fall within protein-coding regions but enrichment of specific, non random, SLS sub-populations of higher stability was observed within the intergenic regions of the chromosomes of several species. In low-GC firmicutes, most higher stability intergenic SLSs resemble canonical rho-independent transcriptional terminators, but very frequently feature at the 5'-end an additional A-rich stretch complementary to the 3' uridines. In all species, a clearly biased SLS distribution was observed within the intergenic space, with most concentrating at the 3'-end side of flanking CDSs. Some intergenic SLS regions are members of novel repeated sequence families. Conclusion In depth analysis of SLS features and distribution in 40 different bacterial genomes showed the presence of non random populations of such structures in all species. Many of these structures are plausibly transcribed, and might be involved in the control of transcription termination, or might serve as RNA elements which can enhance either the stability or
Stem-loop structures in prokaryotic genomes
Petrillo, Mauro; Silvestro, Giustina; Di Nocera, Pier Paolo; Boccia, Angelo; Paolella, Giovanni
2006-01-01
Background Prediction of secondary structures in the expressed sequences of bacterial genomes allows to investigate spontaneous folding of the corresponding RNA. This is particularly relevant in untranslated mRNA regions, where base pairing is less affected by interactions with the translation machinery. Relatively large stem-loops significantly contribute to the formation of more complex secondary structures, often important for the activity of sequence elements controlling gene expression. Results Systematic analysis of the distribution of stem-loop structures (SLSs) in 40 wholly-sequenced bacterial genomes is presented. SLSs were searched as stems measuring at least 12 bp, bordering loops 5 to 100 nt in length. G-U pairing in the stems was allowed. SLSs found in natural genomes are constantly more numerous and stable than those expected to randomly form in sequences of comparable size and composition. The large majority of SLSs fall within protein-coding regions but enrichment of specific, non random, SLS sub-populations of higher stability was observed within the intergenic regions of the chromosomes of several species. In low-GC firmicutes, most higher stability intergenic SLSs resemble canonical rho-independent transcriptional terminators, but very frequently feature at the 5'-end an additional A-rich stretch complementary to the 3' uridines. In all species, a clearly biased SLS distribution was observed within the intergenic space, with most concentrating at the 3'-end side of flanking CDSs. Some intergenic SLS regions are members of novel repeated sequence families. Conclusion In depth analysis of SLS features and distribution in 40 different bacterial genomes showed the presence of non random populations of such structures in all species. Many of these structures are plausibly transcribed, and might be involved in the control of transcription termination, or might serve as RNA elements which can enhance either the stability or the turnover of cotranscribed
Ponderomotive Acceleration in Coronal Loops
Dahlburg, R. B.; Laming, J. M.; Taylor, B. D.; Obenschain, K.
2016-11-01
Ponderomotive acceleration has been asserted to be a cause of the first ionization potential (FIP) effect, the well-known enhancement in abundance by a factor of 3-4 over photospheric values of elements in the solar corona with FIP less than about 10 eV. It is shown here by means of numerical simulations that ponderomotive acceleration occurs in solar coronal loops, with the appropriate magnitude and direction, as a “by-product” of coronal heating. The numerical simulations are performed with the HYPERION code, which solves the fully compressible three-dimensional magnetohydrodynamic equations including nonlinear thermal conduction and optically thin radiation. Numerical simulations of coronal loops with an axial magnetic field from 0.005 to 0.02 T and lengths from 25,000 to 75,000 km are presented. In the simulations the footpoints of the axial loop magnetic field are convected by random, large-scale motions. There is a continuous formation and dissipation of field-aligned current sheets, which act to heat the loop. As a consequence of coronal magnetic reconnection, small-scale, high-speed jets form. The familiar vortex quadrupoles form at reconnection sites. Between the magnetic footpoints and the corona the reconnection flow merges with the boundary flow. It is in this region that the ponderomotive acceleration occurs. Mirroring the character of the coronal reconnection, the ponderomotive acceleration is also found to be intermittent.
Dirac Induction for loop groups
Posthuma, H.
2011-01-01
Using a coset version of the cubic Dirac operators for affine Lie algebras, we give an algebraic construction of the Dirac induction homomorphism for loop group representations. With this, we prove a homogeneous generalization of the Weyl-Kac character formula and show compatibility with Dirac induc
Luthe, T
2016-01-01
We provide an update on a long-term project that aims at evaluating massive vacuum integrals at the five-loop frontier, with high precision and in various space-time dimensions. A number of applications are sketched, mainly concerning the determination of anomalous dimensions, for quantum field theories in four, three and two dimensions.
Loop quantum gravity and observations
Barrau, A
2014-01-01
Quantum gravity has long been thought to be completely decoupled from experiments or observations. Although it is true that smoking guns are still missing, there are now serious hopes that quantum gravity phenomena might be tested. We review here some possible ways to observe loop quantum gravity effects either in the framework of cosmology or in astroparticle physics.
The Diffeomorphism Constraint Operator in Loop Quantum Gravity
Laddha, Alok
2011-01-01
We construct the smeared diffeomorphism constraint operator at finite triangulation from the basic holonomy- flux operators of Loop Quantum Gravity, evaluate its continuum limit on the Lewandowski- Marolf habitat and show that the action of the continuum operator provides an anomaly free representation of the Lie algebra of diffeomorphisms of the 3- manifold. Key features of our analysis include: (i) finite triangulation approximants to the curvature, $F_{ab}^i$ of the Ashtekar- Barbero connection which involve not only small loop holonomies but also small surface fluxes as well as an explicit dependence on the edge labels of the spin network being acted on (ii) the dependence of the small loop underlying the holonomy on both the direction and magnitude of the shift vector field (iii) continuum constraint operators which do {\\em not} have finite action on the kinematic Hilbert space, thus implementing a key lesson from recent studies of parameterised field theory by the authors. Features (i) and (ii) provide ...
Path Integral for Lattice Staggered Fermions in the Loop Representation
Aroca, J M; Gambini, R
1998-01-01
The path integral formulation in terms of loop variables is introduced for lattice gauge theories with dynamical fermions. The path integral of lattice compact QED with staggered fermions is expressed as a sum over surfaces with border on self-avoiding fermionic paths. Each surface is weighted with a classical action -- written in terms of integer gauge invariant variables -- which gives via transfer matrix method the Hamiltonian of the loop or P-representation. The surfaces correspond to the world sheets of loop-like pure electric flux excitations and meson-like configurations (open electric flux tubes carrying matter fields at their ends). The gauge non-redundancy and the geometric transparency are two appealing features of this description. From the computational point of view, it involves fewer degrees of freedom than the Kogut-Susskind formulation and offers the possibility of alternative numerical methods for dynamical fermions.
Principles of agonist recognition in Cys-loop receptors
Timothy eLynagh
2014-04-01
Full Text Available Cys-loop receptors are ligand-gated ion channels that are activated by a structurally diverse array of neurotransmitters, including acetylcholine, serotonin, glycine and GABA. After the term chemoreceptor emerged over 100 years ago, there was some wait until affinity labeling, molecular cloning, functional studies and X-ray crystallography experiments identified the extracellular interface of adjacent subunits as the principal site of agonist binding. The question of how subtle differences at and around agonist-binding sites of different Cys-loop receptors can accommodate transmitters as chemically diverse as glycine and serotonin has been subject to intense research over the last three decades. This review outlines the functional diversity and current structural understanding of agonist-binding sites, including those of invertebrate Cys-loop receptors. Together, this provides a framework to understand the atomic determinants involved in how these valuable therapeutic targets recognize and bind their ligands.
Cyclic coordinate descent: A robotics algorithm for protein loop closure.
Canutescu, Adrian A; Dunbrack, Roland L
2003-05-01
In protein structure prediction, it is often the case that a protein segment must be adjusted to connect two fixed segments. This occurs during loop structure prediction in homology modeling as well as in ab initio structure prediction. Several algorithms for this purpose are based on the inverse Jacobian of the distance constraints with respect to dihedral angle degrees of freedom. These algorithms are sometimes unstable and fail to converge. We present an algorithm developed originally for inverse kinematics applications in robotics. In robotics, an end effector in the form of a robot hand must reach for an object in space by altering adjustable joint angles and arm lengths. In loop prediction, dihedral angles must be adjusted to move the C-terminal residue of a segment to superimpose on a fixed anchor residue in the protein structure. The algorithm, referred to as cyclic coordinate descent or CCD, involves adjusting one dihedral angle at a time to minimize the sum of the squared distances between three backbone atoms of the moving C-terminal anchor and the corresponding atoms in the fixed C-terminal anchor. The result is an equation in one variable for the proposed change in each dihedral. The algorithm proceeds iteratively through all of the adjustable dihedral angles from the N-terminal to the C-terminal end of the loop. CCD is suitable as a component of loop prediction methods that generate large numbers of trial structures. It succeeds in closing loops in a large test set 99.79% of the time, and fails occasionally only for short, highly extended loops. It is very fast, closing loops of length 8 in 0.037 sec on average.
Long-term outcome of gastric access loop in hepaticojejunostomy
Eswaran Selvakumar; Shanmugasundaram Rajendran; Tirupporur G. Balachandar; Devy Gounder Kannan; Satyanesan Jeswanth; Palaniappan Ravichandran; Rajagopal Surendran
2008-01-01
BACKGROUND: The incidence of hepaticojejunostomy stricture is 4%-10%in experienced centres. Many access loops have been designed and used to facilitate endoscopic intervention for this complication of hepaticojejunostomy. In this study, we investigated the effectiveness and safety of gastric access loop. METHODS: A retrospective analysis was conducted on 13 patients who had undergone hepaticojejunostomy with gastric access loop between June 1999 and September 2003. Eleven patients were followed up for a mean period of 51 months (range 20-81 months). Two patients were lost to follow up. RESULTS: On follow-up, 8 patients had patent jejuno-gastrostomy (end to side anastomosis between Roux loop of jejunum and stomach) and hepaticojejunostomy. Three patients developed stricture of jejunogastrostomy at 41 months, 63 months and 81 months of follow-up. Among these 3 patients, one also had hepaticojejunostomy stricture. In the patient with hepaticojejunostomy stricture, dilatation of jejunogastrostomy stricture was attempted but failed. None of the patients had any evidence of bile gastritis/cholangitis. There was no procedure related morbidity/mortality. CONCLUSIONS: Further studies involving large numbers of patients are required before wide application of gastric access loop in hepaticojejunostomy though it is a safer option than percutaneous transhepatic manipulations or revision surgery.
Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma.
Thayanithy, Venugopal; Sarver, Aaron L; Kartha, Reena V; Li, Lihua; Angstadt, Andrea Y; Breen, Matthew; Steer, Clifford J; Modiano, Jaime F; Subramanian, Subbaya
2012-01-01
Osteosarcoma (OS) is the common histological form of primary bone cancer and one of the leading aggressive cancers in children under age fifteen. Although several genetic predisposing conditions have been associated with OS the understanding of its molecular etiology is limited. Here, we show that microRNAs (miRNAs) at the chr.14q32 locus are significantly downregulated in osteosarcoma compared to normal bone tissues. Bioinformatic predictions identified that a subset of 14q32 miRNAs (miR-382, miR-369-3p, miR-544 and miR-134) could potentially target cMYC transcript. The physical interaction between these 14q32 miRNAs and cMYC was validated using reporter assays. Further, restoring expression of these four 14q32 miRNAs decreased cMYC levels and induced apoptosis in Saos2 cells. We also show that exogenous expression of 14q32 miRNAs in Saos2 cells significantly downregulated miR-17-92, a transcriptional target of cMYC. The pro-apoptotic effect of 14q32 miRNAs in Saos2 cells was rescued either by overexpression of cMYC cDNA without the 3'UTR or with miR-17-92 cluster. Further, array comparative genomic hybridization studies showed no DNA copy number changes at 14q32 locus in OS patient samples suggesting that downregulation of 14q32 miRNAs are not due to deletion at this locus. Together, our data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis.
High Tc superconducting small loop antenna
Wu, Z.; Mehler, M.J.; Maclean, T.S.M.; Lancaster, M.J.; Gough, C.E. (Univ. of Birmingham (UK)); Alford, N. (I.C.I. Advanced Materials Div., Runcorn (UK))
1989-12-01
The improvement in the radiation efficiency of an electrically small loop antenna is analysed when it is fabricated from a superconductor, and experimental results for a liquid nitrogen cooled, ceramic superconducting loop at 450MHz are presented. (orig.).
Crystal packing effects on protein loops.
Rapp, Chaya S; Pollack, Rena M
2005-07-01
The effects of crystal packing on protein loop structures are examined by (1) a comparison of loops in proteins that have been crystallized in alternate packing arrangements, and (2) theoretical prediction of loops both with and without the inclusion of the crystal environment. Results show that in a minority of cases, loop geometries are dependent on crystal packing effects. Explicit representation of the crystal environment in a loop prediction algorithm can be used to model these effects and to reconstruct the structures, and relative energies, of a loop in alternative packing environments. By comparing prediction results with and without the inclusion of the crystal environment, the loop prediction algorithm can further be used to identify cases in which a crystal structure does not represent the most stable state of a loop in solution. We anticipate that this capability has implications for structural biology.
Modified Continuous Loop Technique for microvascular anastomosis
Kumar Pramod
2001-01-01
Full Text Available A modified method of continuous loop technique for microvascular anastomosis is described. The handling of loop is easier & even last suture is placed under vision. This makes the microvascular anastomosis easier and simpler.
Loop Quantum Cosmology and Spin Foams
Ashtekar, Abhay; Henderson, Adam
2009-01-01
Loop quantum cosmology (LQC) is used to provide concrete evidence in support of the general paradigm underlying spin foam models (SFMs). Specifically, it is shown that: i) the physical inner product in the timeless framework equals the transition amplitude in the deparameterized theory; ii) this quantity admits a %convergent vertex expansion a la SFMs in which the $M$-th term refers just to $M$ volume transitions, without any reference to the time at which the transition takes place; iii) the exact physical inner product is obtained by summing over just the discrete geometries; no `continuum limit' is involved; and, iv) the vertex expansion can be interpreted as a perturbative expansion in the spirit of group field theory. This sum over histories reformulation of LQC also addresses certain other issues which are briefly summarized.
Resumming the POPE at One Loop
Lam, Ho Tat
2016-01-01
The Pentagon Operator Product Expansion represents polygonal Wilson loops in planar $\\mathcal{N}=4$ super Yang-Mills in terms of a series of flux tube excitations for finite coupling. We demonstrate how to re-sum this series at the one loop level for the hexagonal Wilson loop dual to the six-point MHV amplitude. By summing over a series of effective excitations we find expressions which integrate to logarithms and polylogarithms, reproducing the known one-loop result.
Loop Equations in Abelian Gauge Theories
Di Bartolo, C; Pe~na, F; Bartolo, Cayetano Di; Leal, Lorenzo; Peña, Francisco
2005-01-01
The equations obeyed by the vacuum expectation value of the Wilson loop of Abelian gauge theories are considered from the point of view of the loop-space. An approximative scheme for studying these loop-equations for lattice Maxwell theory is presented. The approximation leads to a partial difference equation in the area and length variables of the loop, and certain physically motivated ansatz is seen to reproduce the mean field results from a geometrical perspective.
Estimation of complex permittivity using loop antenna
Lenler-Eriksen, Hans-Rudolph; Meincke, Peter
2004-01-01
A method for estimating the complex permittivity of materials in the vicinity of a loop antenna is proposed. The method is based on comparing measured and numerically calculated input admittances for the loop antenna.......A method for estimating the complex permittivity of materials in the vicinity of a loop antenna is proposed. The method is based on comparing measured and numerically calculated input admittances for the loop antenna....
Estimation of complex permittivity using loop antenna
Lenler-Eriksen, Hans-Rudolph; Meincke, Peter
2004-01-01
A method for estimating the complex permittivity of materials in the vicinity of a loop antenna is proposed. The method is based on comparing measured and numerically calculated input admittances for the loop antenna.......A method for estimating the complex permittivity of materials in the vicinity of a loop antenna is proposed. The method is based on comparing measured and numerically calculated input admittances for the loop antenna....
Polyhedra in loop quantum gravity
Bianchi, Eugenio; Speziale, Simone
2010-01-01
Interwiners are the building blocks of spin-network states. The space of intertwiners is the quantization of a classical symplectic manifold introduced by Kapovich and Millson. Here we show that a theorem by Minkowski allows us to interpret generic configurations in this space as bounded convex polyhedra in Euclidean space: a polyhedron is uniquely described by the areas and normals to its faces. We provide a reconstruction of the geometry of the polyhedron: we give formulas for the edge lengths, the volume and the adjacency of its faces. At the quantum level, this correspondence allows us to identify an intertwiner with the state of a quantum polyhedron, thus generalizing the notion of quantum tetrahedron familiar in the loop quantum gravity literature. Moreover, coherent intertwiners result to be peaked on the classical geometry of a polyhedron. We discuss the relevance of this result for loop quantum gravity. In particular, coherent spin-network states with nodes of arbitrary valence represent a collection...
Nucleosome repositioning via loop formation
Kulic, M L
2002-01-01
Active (catalysed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eucaryotic genes. Here we consider theoretically the intrinsic mechanism and study in detail the energetics and dynamics of DNA-loop-mediated nucleosome repositioning, as previously proposed by Schiessel et al. (H. Schiessel, J. Widom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\\it Phys. Rev. Lett.} 86:4414-4417). The surprising outcome of the present study is the inherent nonlocality of nucleosome motion within this model -- being a direct physical consequence of the loop mechanism. On long enough DNA templates the longer jumps dominate over the previously predicted local motion, a fact that contrasts simple diffusive mechanisms considered before. The possible experimental outcome resulting from the considered mechanism is predicted, discussed and compared to existing experimental findings.
The Statistical Loop Analyzer (SLA)
Lindsey, W. C.
1985-01-01
The statistical loop analyzer (SLA) is designed to automatically measure the acquisition, tracking and frequency stability performance characteristics of symbol synchronizers, code synchronizers, carrier tracking loops, and coherent transponders. Automated phase lock and system level tests can also be made using the SLA. Standard baseband, carrier and spread spectrum modulation techniques can be accomodated. Through the SLA's phase error jitter and cycle slip measurements the acquisition and tracking thresholds of the unit under test are determined; any false phase and frequency lock events are statistically analyzed and reported in the SLA output in probabilistic terms. Automated signal drop out tests can be performed in order to trouble shoot algorithms and evaluate the reacquisition statistics of the unit under test. Cycle slip rates and cycle slip probabilities can be measured using the SLA. These measurements, combined with bit error probability measurements, are all that are needed to fully characterize the acquisition and tracking performance of a digital communication system.
Loop Diuretics in Clinical Practice.
Oh, Se Won; Han, Sang Youb
2015-06-01
Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are the most potent diuretics. In this article, we review five important aspects of loop diuretics, in particular furosemide, which must be considered when prescribing this medicine: (1) oral versus intravenous treatment, (2) dosage, (3) continuous versus bolus infusion, (4) application in chronic kidney disease patients, and (5) side effects. The bioavailability of furosemide differs between oral and intravenous therapy. Additionally, the threshold and ceiling doses of furosemide differ according to the particular clinical condition of the patient, for example in patients with severe edema or chronic kidney disease. To maximize the efficiency of furosemide, a clear understanding of how the mode of delivery will impact bioavailability and the required dosage is necessary.
Deconfinement and virtual quark loops
Çelik, T.; Engels, J.; Satz, H.
1983-12-01
We calculate paer Monte Carlo evaluation on an 83 × 3 lattice the energy density ɛG of the gluon sector of QCD, including virtual quark loops up to the fourth power in the hopping parameter expansion. For light quarks of one flavour, we observe at T/ΛL 95 +/- 10 a rapid variation of ɛG in T, accompanied by strong fluctuations from iteration to iteration. as clear signal of the deconfinement transition.
Quantum Reduced Loop Gravity and the foundation of Loop Quantum Cosmology
Alesci, Emanuele
2016-01-01
Quantum Reduced Loop Gravity is a promising framework for linking Loop Quantum Gravity and the effective semiclassical dynamics of Loop Quantum Cosmology. We review its basic achievements and its main perspectives, outlining how it provides a quantum description of the Universe in terms of a cuboidal graph which constitutes the proper framework for applying loop techniques in a cosmological setting.
Ponderomotive Acceleration in Coronal Loops
Dahlburg, R B; Taylor, B D; Obenschain, K
2016-01-01
Ponderomotive acceleration has been asserted to be a cause of the First Ionization Potential (FIP) effect, the by now well known enhancement in abundance by a factor of 3-4 over photospheric values of elements in the solar corona with FIP less than about 10 eV. It is shown here by means of numerical simulations that ponderomotive acceleration occurs in solar coronal loops, with the appropriate magnitude and direction, as a "byproduct" of coronal heating. The numerical simulations are performed with the HYPERION code, which solves the fully compressible three-dimensional magnetohydrodynamic equations including nonlinear thermal conduction and optically thin radiation. Numerical simulations of a coronal loops with an axial magnetic field from 0.005 Teslas to 0.02 Teslas and lengths from 25000 km to 75000 km are presented. In the simulations the footpoints of the axial loop magnetic field are convected by random, large-scale motions. There is a continuous formation and dissipation of field-aligned current sheets...
Modeling Phase-Locked Loops Using Verilog
2007-11-01
a charge pump, the phase detector has a tri-state output that can drive a opamp loop filter directly. This signal is conditioned by the charge pump...then it can directly drive an opamp based loop filter. Most loop filters are based upon an integrator loop. The integrator loop filter is advantageous...replaced with an accumulator. The opamp circuit can be replaced by a digital filter using Z-transform theory z=exp(jwT), where T is the sampling
The space of states of quantum gravity in terms of loops and extended loops some remarks
Di Bartolo, C; Griego, J R; Pullin, J; Di Bartolo, Cayetano; Gambini, Rodolfo; Griego, Jorge; Pullin, Jorge
1995-01-01
This article reviews the status of several solutions to all the constraints of quantum gravity that have been proposed in terms of loops and extended loops. We discuss pitfalls of several of the results and in particular discuss the issues of covariance and regularization of the constraints in terms of extended loops. We also propose a formalism for ``thickened out loops'' which does not face the covariance problems of extended loops and may allow to regularize expressions in a consistent manner.
Hyperstaticity and loops in frictional granular packings
Tordesillas, Antoinette; Lam, Edward; Metzger, Philip T.
2009-06-01
The hyperstatic nature of granular packings of perfectly rigid disks is analyzed algebraically and through numerical simulation. The elementary loops of grains emerge as a fundamental element in addressing hyperstaticity. Loops consisting of an odd number of grains behave differently than those with an even number. For odd loops, the latent stresses are exterior and are characterized by the sum of frictional forces around each loop. For even loops, the latent stresses are interior and are characterized by the alternating sum of frictional forces around each loop. The statistics of these two types of loop sums are found to be Gibbsian with a "temperature" that is linear with the friction coefficient μ when μ<1.
The extended loop representation of quantum gravity
Di Bartolo, C; Griego, J R
1995-01-01
A new representation of Quantum Gravity is developed. This formulation is based on an extension of the group of loops. The enlarged group, that we call the Extended Loop Group, behaves locally as an infinite dimensional Lie group. Quantum Gravity can be realized on the state space of extended loop dependent wavefunctions. The extended representation generalizes the loop representation and contains this representation as a particular case. The resulting diffeomorphism and hamiltonian constraints take a very simple form and allow to apply functional methods and simplify the loop calculus. In particular we show that the constraints are linear in the momenta. The nondegenerate solutions known in the loop representation are also solutions of the constraints in the new representation. The practical calculation advantages allows to find a new solution to the Wheeler-DeWitt equation. Moreover, the extended representation puts in a precise framework some of the regularization problems of the loop representation. We sh...
Editorial Office
1979-09-01
Full Text Available Community involvement is the main theme of Health Year. Governments have a responsibility for the health of their people, and in this country under the present 3-tier system of government, the responsibility for the rendering of health services is divided between central, provincial and local government. However, under our democratic system, all people have the right to, and it is indeed their duty, to participate individually and collectively in the planning and implementation of services to meet their health needs. Ultimately, through involvement of individuals, families and communities, greater self-reliance is achieved leading to greater responsibility being assumed by people for their own health.
Tran, Huyen Thi; Hong, Myoung Ki; Ngo, Ho Phuong Thuy; Huynh, Kim Hung; Ahn, Yeh Jin; Wang, Zhong; Kang, Lin Woo
2016-01-01
D-Alanyl-D-alanine is an essential precursor of bacterial peptidoglycan and is synthesized by D-alanine-D-alanine ligase (DDL) with hydrolysis of ATP; this reaction makes DDL an important drug target for the development of antibacterial agents. Five crystal structures of DDL from Yersinia pestis (YpDDL) were determined at 1.7-2.5 Å resolution: apo, AMP-bound, ADP-bound, adenosine 5'-(β,γ-imido)triphosphate-bound, and D-alanyl-D-alanine- and ADP-bound structures. YpDDL consists of three domains, in which four loops, loop 1, loop 2 (the serine loop), loop 3 (the ω-loop) and loop 4, constitute the binding sites for two D-alanine molecules and one ATP molecule. Some of them, especially the serine loop and the ω-loop, show flexible conformations, and the serine loop is mainly responsible for the conformational change in substrate nucleotide phosphates. Enzyme-kinetics assays were carried out for both the D-alanine and ATP substrates and a substrate-binding mechanism was proposed for YpDDL involving conformational changes of the loops.
Double loop control strategy with different time steps based on human characteristics.
Gu, Gwang Min; Lee, Jinoh; Kim, Jung
2012-01-01
This paper proposes a cooperative control strategy in consideration of the force sensitivity of human. The strategy consists of two loops: one is the intention estimation loop whose sampling time can be variable in order to investigate the effect of the sampling time; the other is the position control loop with fixed time step. A high sampling rate is not necessary for the intention estimation loop due to the bandwidth of the mechanoreceptors in humans. In addition, the force sensor implemented in the robot is sensitive to the noise induced from the sensor itself and tremor of the human. Multiple experiments were performed with the experimental protocol using various time steps of the intention estimation loop to find the suitable sampling times in physical human robot interaction. The task involves pull-and-push movement with a two-degree-of-freedom robot, and the norm of the interaction force was obtained for each experiment as the measure of the cooperative control performance.
Enzyme Selectivity Fine-Tuned through Dynamic Control of a Loop.
Vögeli, Beat; Bibow, Stefan; Chi, Celestine N
2016-02-24
Allostery has been revealed as an essential property of all proteins. For enzymes, shifting of the structural equilibrium distribution at one site can have substantial impacts on protein dynamics and selectivity. Promising sites of remotely shifting such a distribution by changing the dynamics would be at flexible loops because relatively large changes may be achieved with minimal modification of the protein. A ligand-selective change of binding affinity to the active site of cyclophilin is presented involving tuning of the dynamics of a highly flexible loop. Binding affinity is increased upon substitution of double Gly to Ala at the hinge regions of the loop. Quenching of the motional amplitudes of the loop slightly rearranges the active site. In particular, key residues for binding Phe60 and His126 adopt a more fixed orientation in the bound protein. Our system may serve as a model system for studying the effects of various time scales of loop motion on protein function tuned by mutations.
The elastic QCD dipole amplitude at one-loop
Navelet, H
1999-01-01
We derive the analytic expression of the two one-loop dipole contributions to the elastic 4-gluon amplitude in QCD. The first one corresponds to the double QCD pomeron exchange, the other to an order alpha^2 correction to one-pomeron exchange. Both are expressed in terms of the square of the recently derived triple QCD pomeron vertex and involve a summation over all conformal Eigenvectors of the BFKL kernel.
Singularities in loop quantum cosmology.
Cailleteau, Thomas; Cardoso, Antonio; Vandersloot, Kevin; Wands, David
2008-12-19
We show that simple scalar field models can give rise to curvature singularities in the effective Friedmann dynamics of loop quantum cosmology (LQC). We find singular solutions for spatially flat Friedmann-Robertson-Walker cosmologies with a canonical scalar field and a negative exponential potential, or with a phantom scalar field and a positive potential. While LQC avoids big bang or big rip type singularities, we find sudden singularities where the Hubble rate is bounded, but the Ricci curvature scalar diverges. We conclude that the effective equations of LQC are not in themselves sufficient to avoid the occurrence of curvature singularities.
Loop equations from differential systems
Eynard, Bertrand; Marchal, Olivier
2016-01-01
To any differential system $d\\Psi=\\Phi\\Psi$ where $\\Psi$ belongs to a Lie group (a fiber of a principal bundle) and $\\Phi$ is a Lie algebra $\\mathfrak g$ valued 1-form on a Riemann surface $\\Sigma$, is associated an infinite sequence of "correlators" $W_n$ that are symmetric $n$-forms on $\\Sigma^n$. The goal of this article is to prove that these correlators always satisfy "loop equations", the same equations satisfied by correlation functions in random matrix models, or the same equations as Virasoro or W-algebra constraints in CFT.
West, J; Reichardt, I; Stil, J; Kothes, R; Jaffe, T
2016-01-01
The Cygnus Loop is a well-studied supernova remnant (SNR) that has been observed across the electromagnetic spectrum. Although widely believed to be an SNR shell with a blow- out region in the south, we consider the possibility that this object is two SNRs projected along the same line-of-sight by using multi-wavelength images and modelling. Our results show that a model of two objects including some overlap region/interaction between the two objects has the best match to the observed data.
Loop Virasoro Lie conformal algebra
Wu, Henan, E-mail: wuhenanby@163.com; Chen, Qiufan; Yue, Xiaoqing [Department of Mathematics, Tongji University, Shanghai 200092 (China)
2014-01-15
The Lie conformal algebra of loop Virasoro algebra, denoted by CW, is introduced in this paper. Explicitly, CW is a Lie conformal algebra with C[∂]-basis (L{sub i} | i∈Z) and λ-brackets [L{sub i} {sub λ} L{sub j}] = (−∂−2λ)L{sub i+j}. Then conformal derivations of CW are determined. Finally, rank one conformal modules and Z-graded free intermediate series modules over CW are classified.
Overview of Loop Heat Pipe Operation
Ku, Jentung
1999-01-01
Loop heat pipes (LHP's) are two-phase heat transfer devices that utilize the evaporation and condensation of a working fluid to transfer heat, and the capillary forces developed in the porous wicks to circulate the fluid. The LHP was first developed in the former Soviet Union in the early 1980s, about the same time that the capillary pumped loop (CPL) was developed in the United States. The LHP is known for its high pumping capability and robust operation mainly due to the use of fine-pored metal wicks and an integral evaporator/hydro-accumulator design. The LHP technology is rapidly gaining acceptance in aerospace community. It is the baseline design for thermal control of several spacecraft, including NASA's GLAS and Chemistry, ESA's ATLID, CNES' STENTOR, RKA's OBZOR, and several commercial satellites. Numerous LHP papers have been published since the mid-1980's. Most papers presented test results and discussions on certain specific aspects of the LHP operation. LHP's and CPL's show many similarities in their operating principles and performance characteristics. However, they also display significant differences in many aspects of their operation. Some of the LHP behaviors may seem strange or mysterious, even to experienced CPL practitioners. The main purpose of this paper is to present a systematic description of the operating principles and thermal-hydraulic behaviors of LHP'S. LHP operating principles will be given first, followed by a description of the thermal-hydraulics involved in LHP operation. Operating characteristics and important parameters affecting the LHP operation will then be described in detail. Peculiar behaviors of the LHP, including temperature hysteresis and temperature overshoot during start-up, will be explained. For simplicity, most discussions will focus upon LHP's with a single evaporator and a single condenser, but devices with multiple evaporators and condensers will also be discussed. Similarities and differences between LHP's and
Using the Meeting Graph Framework to Minimise Kernel Loop Unrolling for Scheduled Loops
Bachir, Mounira; Gregg, David; Touati, Sid-Ahmed-Ali
This paper improves our previous research effort [1] by providing an efficient method for kernel loop unrolling minimisation in the case of already scheduled loops, where circular lifetime intervals are known. When loops are software pipelined, the number of values simultaneously alive becomes exactly known giving better opportunities for kernel loop unrolling. Furthermore, fixing circular lifetime intervals allows us to reduce the algorithmic complexity of our method compared to [1] by computing a new research space for minimal kernel loop unrolling. The meeting graph (MG) is one of the [3] frameworks proposed in the literature which models loop unrolling and register allocation together in a common formal framework for software pipelined loops. Although MG significantly improves loop register allocation, the computed loop unrolling may lead to unpractical code growth.
Are Coronal Loops Isothermal or Multithermal? Yes!
Schmelz, J T; Rightmire, L A; Kimble, J A; Del Zanna, G; Cirtain, J W; DeLuca, E E; Mason, H E
2009-01-01
Surprisingly few solar coronal loops have been observed simultaneously with TRACE and SOHO/CDS, and even fewer analyses of these loops have been conducted and published. The SOHO Joint Observing Program 146 was designed in part to provide the simultaneous observations required for in-depth temperature analysis of active region loops and determine whether these loops are isothermal or multithermal. The data analyzed in this paper were taken on 2003 January 17 of AR 10250. We used TRACE filter ratios, emission measure loci, and two methods of differential emission measure analysis to examine the temperature structure of three different loops. TRACE and CDS observations agree that Loop 1 is isothermal with Log T $=$ 5.85, both along the line of sight as well as along the length of the loop leg that is visible in the CDS field of view. Loop 2 is hotter than Loop 1. It is multithermal along the line of sight, with significant emission between 6.2 $<$ Log T $<$ 6.4, but the loop apex region is out of the CDS ...
Gauge theory loop operators and Liouville theory
Drukker, Nadav [Humboldt Univ. Berlin (Germany). Inst. fuer Physik; Gomis, Jaume; Okuda, Takuda [Perimeter Inst. for Theoretical Physics, Waterloo, ON (Canada); Teschner, Joerg [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)
2009-10-15
We propose a correspondence between loop operators in a family of four dimensional N=2 gauge theories on S{sup 4} - including Wilson, 't Hooft and dyonic operators - and Liouville theory loop operators on a Riemann surface. This extends the beautiful relation between the partition function of these N=2 gauge theories and Liouville correlators found by Alday, Gaiotto and Tachikawa. We show that the computation of these Liouville correlators with the insertion of a Liouville loop operator reproduces Pestun's formula capturing the expectation value of a Wilson loop operator in the corresponding gauge theory. We prove that our definition of Liouville loop operators is invariant under modular transformations, which given our correspondence, implies the conjectured action of S-duality on the gauge theory loop operators. Our computations in Liouville theory make an explicit prediction for the exact expectation value of 't Hooft and dyonic loop operators in these N=2 gauge theories. The Liouville loop operators are also found to admit a simple geometric interpretation within quantum Teichmueller theory as the quantum operators representing the length of geodesics. We study the algebra of Liouville loop operators and show that it gives evidence for our proposal as well as providing definite predictions for the operator product expansion of loop operators in gauge theory. (orig.)
Efficient Loop Navigation for Symbolic Execution
Obdrzalek, Jan
2011-01-01
Symbolic execution is a successful and very popular technique used in software verification and testing. A key limitation of symbolic execution is in dealing with code containing loops. The problem is that even a single loop can generate a huge number of different symbolic execution paths, corresponding to different number of loop iterations and taking various paths through the loop. We introduce a technique which, given a start location above some loops and a target location anywhere below these loops, returns a feasible path between these two locations, if such a path exists. The technique infers a collection of constraint systems from the program and uses them to steer the symbolic execution towards the target. On reaching a loop it iteratively solves the appropriate constraint system to find out which path through this loop to take, or, alternatively, whether to continue below the loop. To construct the constraint systems we express the values of variables modified in a loop as functions of the number of ...
Thermodynamic examination of 1- to 5-nt purine bulge loops in RNA and DNA constructs.
Strom, Shane; Shiskova, Evgenia; Hahm, Yaeeun; Grover, Neena
2015-07-01
Bulge loops are common features of RNA structures that are involved in the formation of RNA tertiary structures and are often sites for interactions with proteins and ions. Minimal thermodynamic data currently exist on the bulge size and sequence effects. Using thermal denaturation methods, thermodynamic properties of 1- to 5-nt adenine and guanine bulge loop constructs were examined in 10 mM MgCl(2) or 1 M KCl. The [Formula: see text] loop parameters for 1- to 5-nt purine bulge loops in RNA constructs were between 3.07 and 5.31 kcal/mol in 1 M KCl buffer. In 10 mM magnesium ions, the ΔΔG° values relative to 1 M KCl were 0.47-2.06 kcal/mol more favorable for the RNA bulge loops. The [Formula: see text] loop parameters for 1- to 5-nt purine bulge loops in DNA constructs were between 4.54 and 5.89 kcal/mol. Only 4- and 5-nt guanine constructs showed significant change in stability for the DNA constructs in magnesium ions. A linear correlation is seen between the size of the bulge loop and its stability. New prediction models are proposed for 1- to 5-nt purine bulge loops in RNA and DNA in 1 M KCl. We show that a significant stabilization is seen for small bulge loops in RNA in the presence of magnesium ions. A prediction model is also proposed for 1- to 5-nt purine bulge loop RNA constructs in 10 mM magnesium chloride.
One-loop Matching and Running with Covariant Derivative Expansion
Henning, Brian; Murayama, Hitoshi
2016-01-01
We develop tools for performing effective field theory (EFT) calculations in a manifestly gauge-covariant fashion. We clarify how functional methods account for one-loop diagrams resulting from the exchange of both heavy and light fields, as some confusion has recently arisen in the literature. To efficiently evaluate functional traces containing these "mixed" one-loop terms, we develop a new covariant derivative expansion (CDE) technique that is capable of evaluating a much wider class of traces than previous methods. The technique is detailed in an appendix, so that it can be read independently from the rest of this work. We review the well-known matching procedure to one-loop order with functional methods. What we add to this story is showing how to isolate one-loop terms coming from diagrams involving only heavy propagators from diagrams with mixed heavy and light propagators. This is done using a non-local effective action, which physically connects to the notion of "integrating out" heavy fields. Lastly...
Inferring Flare Loop Parameters with Measurements of Standing Sausage Modes
Guo, Ming-Zhe; Chen, Shao-Xia; Li, Bo; Xia, Li-Dong; Yu, Hui
2016-03-01
Standing fast sausage modes in flare loops were suggested to account for a considerable number of quasi-periodic pulsations (QPPs) in the light curves of solar flares. This study continues our investigation into the possibility of inverting the measured periods P and damping times τ of sausage modes to deduce the transverse Alfvén time R/v_{Ai}, density contrast ρi/ρe, and the steepness of the density distribution transverse to flare loops. A generic dispersion relation governing linear sausage modes is derived for pressureless cylinders where density inhomogeneity of arbitrary form takes place within the cylinder. We show that in general the inversion problem is under-determined for QPP events where only a single sausage mode exists, whether the measurements are spatially resolved or unresolved. While R/v_{Ai} can be inferred to some extent, the range of possible steepness parameters may be too broad to be useful. However, for spatially resolved measurements where an additional mode is present, it is possible to deduce self-consistently ρi/ρe, the profile steepness, and the internal Alfvén speed v_{Ai}. We show that at least for a recent QPP event that involves a fundamental kink mode in addition to a sausage one, flare loop parameters are well constrained even if the specific form of the transverse density distribution remains unknown. We conclude that spatially resolved, multi-mode QPP measurements need to be pursued to infer flare loop parameters.
Electron contribution to the muon anomalous magnetic moment at four loops
Kurz, Alexander; Liu, Tao; Marquard, Peter; Smirnov, Alexander V.; Smirnov, Vladimir A.; Steinhauser, Matthias
2016-03-01
We present results for the QED contributions to the anomalous magnetic moment of the muon containing closed electron loops. The main focus is on perturbative corrections at four-loop order where the external photon couples to the external muon. Furthermore, all four-loop contributions involving simultaneously a closed electron and tau loop are computed. In combination with our recent results on the light-by-light-type corrections (see Ref. [1]), the complete four-loop electron-loop contribution to the anomalous magnetic moment of the muon has been obtained with an independent calculation. Our calculation is based on an asymptotic expansion in the ratio of the electron and the muon mass and shows the importance of higher-order terms in this ratio. We perform a detailed comparison with results available in the literature and find good numerical agreement. As a byproduct, we present analytic results for the on-shell muon mass and wave function renormalization constants at three-loop order including massive closed electron and tau loops, which we also calculated using the method of asymptotic expansion.
Electron contribution to the muon anomalous magnetic moment at four loops
Kurz, Alexander [Karlsruher Institut fuer Technologie (Germany). Inst. fuer Theoretische Teilchenphysik; Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Liu, Tao [Alberta Univ., Edmonton, AB (Canada). Dept. of Physics; Marquard, Peter [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Smirnov, Alexander V. [Moscow State Univ. (Russian Federation). Scientific Research Computing Center; Smirnov, Vladimir A. [Moscow State Univ. (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Humboldt-Universitaet, Berlin (Germany). Inst. fuer Mathematik; Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Steinhauser, Matthias [Karlsruher Institut fuer Technologie (Germany). Inst. fuer Theoretische Teilchenphysik
2016-02-15
We present results for the QED contributions to the anomalous magnetic moment of the muon containing closed electron loops. The main focus is on perturbative corrections at four-loop order where the external photon couples to the external muon. Furthermore, all four-loop contributions involving simultaneously a closed electron and tau loop are computed. In combination with our recent results on the light-by-light-type corrections the complete four-loop electron-loop contribution to the anomalous magnetic moment of the muon has been obtained with an independent calculation. Our calculation is based on an asymptotic expansion in the ratio of the electron and the muon mass and shows the importance of higher order terms in this ratio. We perform a detailed comparison with results available in the literature and find good numerical agreement. As a by-product we present analytic results for the on-shell muon mass and wave function renormalization constants at three-loop order including massive closed electron and tau loops, which we also calculated using the method of asymptotic expansion.
Higher Loop Nonplanar Anomalous Dimensions from Symmetry
Koch, Robert de Mello; Messamah, Ilies
2013-01-01
In this article we study the action of the one loop dilatation operator on operators with a classical dimension of order N. These operators belong to the su(2) sector and are constructed using two complex fields Y and Z. For these operators non-planar diagrams contribute already at the leading order in N and the planar and large N limits are distinct. The action of the one loop and the two loop dilatation operator reduces to a set of decoupled oscillators and factorizes into an action on the Z fields and an action on the Y fields. Direct computation has shown that the action on the Y fields is the same at one and two loops. In this article, using the su(2) symmetry algebra as well as structural features of field theory, we give compelling evidence that the factor in the dilatation operator that acts on the Ys is given by the one loop expression, at any loop order.
Pathak, Ekta; Atri, Neelam; Mishra, Rajeev
2013-01-01
P-loop NTPases represent a large and highly diverse protein family that is involved in variety of cellular functions. Walker A motif forms a typical arched conformation, necessary to accommodate the phosphate moiety of the nucleoside tri (or di-) phosphate in Ploop NTPases. The feature that maintains the ancient architecture of P-loop is unidentified and uncharacterized. Here, using a well established global network parameter, closeness centrality, we identify that Walker A and its flanking regions (N- and C-terminal) have high density of globally connected residue positions. We find that closeness centrality of these residue positions are conserved across common structural core of diverse domains of P-loop NTPase fold. Our results suggest the potential role of globally connected residues in maintaining the local conformation of P-loop.
Two-loop level rainbow-like supersymmetric contribution to the fermion EDM
Yamanaka, Nodoka
2012-01-01
We calculate the two-loop level electric and chromo-electric dipole moments of the fermion involving fermion-sfermion inner loop, gaugino, and higgsino in the minimal supersymmetric standard model, and analyze the chromo-electric dipole moment with the top-stop inner loop. It is found that this contribution is comparable with, and even dominates in some situation over the Barr-Zee type diagram generated from the CP-violation of the top squark sector in TeV scale supersymmetry breaking.
Determining MSSM parameters via chargino production at the LC: a one-loop analysis
Bharucha, Aoife
2012-01-01
Very precise measurements of masses and cross sections are expected to be achievable with a future linear collider. With such an accuracy one must incorporate loop corrections in order to make meaningful predictions for the underlying new physics parameters. For the electroweakino sector, this involves fitting one-loop predictions to expected measurements of the cross section and forward-backward asymmetry for chargino pair production and of the accessible chargino and neutralino masses. We consider two scenarios with characteristic features, chosen taking recent LHC SUSY and Higgs searches into account. Our analysis allows the accurate determination of the desired parameters and, additionally, access to stop sector parameters that enter via loop corrections.
Abstract Acceleration of General Linear Loops
2014-01-01
International audience; We present abstract acceleration techniques for computing loop invariants for numerical programs with linear assignments and conditionals. Whereas abstract interpretation techniques typically over-approximate the set of reachable states iteratively, abstract acceleration captures the effect of the loop with a single, non-iterative transfer function applied to the initial states at the loop head. In contrast to previous acceleration techniques, our approach applies to a...
LMFBR with booster pump in pumping loop
Rubinstein, H.J.
1975-10-14
A loop coolant circulation system is described for a liquid metal fast breeder reactor (LMFBR) utilizing a low head, high specific speed booster pump in the hot leg of the coolant loop with the main pump located in the cold leg of the loop, thereby providing the advantages of operating the main pump in the hot leg with the reliability of cold leg pump operation.
Wilson Loops in Open String Theory
Shiraishi, Kiyoshi
Wilson loop elements on torus are introduced into the partition function of open strings as Polyakov’s path integral at one-loop level. Mass spectra from compactification and expected symmetry breaking are illustrated by choosing the correct weight for the contributions from annulus and Möbius strip. We show that Jacobi’s imaginary transformation connects the mass spectra with the Wilson loops. The application to thermopartition function and cosmological implications are briefly discussed.
Wilson Loops in Open String Theory
Shiraishi, Kiyoshi
2012-01-01
Wilson loop elements on torus are introduced into the partition function of open strings as Polyakov's path integral at one-loop level. Mass spectra from compactification and expected symmetry breaking are illustrated by choosing the correct weight for the contributions from annulus and M\\"obius strip. We show that Jacobi's imaginary transformation connects the mass spectra with the Wilson loops. The application to thermopartition function and cosmological implications are briefly discussed.
Marijan Jurgo
2013-01-01
The paper reviews working principles of phase-locked loop and drawbacks of classical PLL structure in nanometric technologies. It is proposed to replace the classical structure by all-digital phase-locked loop structure. Authors described the main blocks of all-digital phase-locked loop (time to digital converter and digitally controlled oscillator) and overviewed the quantization noise arising in these blocks as well as its minimization strategies. The calculated inverter delay in 65 nm CMOS...
Magnetic Monopole in the Loop Representation
Leal, L; Leal, Lorenzo; Lopez, Alexander
2004-01-01
We quantize the electromagnetic field in the presence of a static magnetic monopole, within the loop-representation formalism. We find that the loop-dependent wave functional becomes multivalued, in the sense that it acquires a dependence on the surfaces bounded by the loop. This generalizes what occurs in quantum mechanics in multiply connected spaces. When Dirac's quantization condition holds, this surface-dependence disappears, together with the effect of the monopole on the electromagnetic field.
A Note on Loop Amplitudes in QED
Brandhuber, Andreas; Vincon, Massimiliano
2009-01-01
We consider the two-loop four-point amplitude in N=2 super QED, and show that there exists an approximate recursive structure similar to that captured by the ABDK/BDS ansatz for MHV amplitudes in N=4 super Yang-Mills. Furthermore, we present a simple relation between the box coefficients of one-loop photon MHV amplitudes in (super) QED, and sums of box coefficients of one-loop MHV amplitudes in (super) Yang-Mills.
Rothrock, Ling
2011-01-01
""Human-in-the-Loop Simulations"" is a compilation of articles from experts in the design, development, and use of human-in-the-loop simulations. The first section of the handbook consists of papers on fundamental concepts in human-in-the-loop simulations, such as object-oriented simulation development, interface design and development, and performance measurement. The second section includes papers from researchers who utilized HITL simulations to inform models of cognitive processes to include decision making and metacognition. The last section describes human-in-the-loop processes for compl
High Temperature Sodium Thermal Convection Test Loop
2001-01-01
A project for the evaluation of compatibility characteristic of structural materials used in China experimental fast reactor(CEFR) has been in operation. The conditions which these structural materials contact with liquid sodium in reactor can be simulated by the tests in high temperature sodium thermal convection test loop. The main aims of designing and constructing the thermal convection test loop is for the corrosion test of CEFR materials, and the objective is to obtain the corrosion data of domestic materials.The main features of the test loop are shown in Fig.1. The primary components of the loop
The emergy analysis of loop circuit.
Cao, Kai; Feng, Xiao
2008-12-01
Emergy analysis can analyze the resource utilization and environmental performance of a system. Loop circuit is a common structure in the process industry, but when emergy analysis is carried out to such structure, mistakes such as emergy double counting often occur. To avoid emergy double counting, two types of loop circuit-direct loop circuit and indirect loop circuit-are theoretically distinguished, and the methods to avoid such mistake are proposed. Finally, PVC production and vinyl acetate production are adopted to demonstrate the methods.
Pseudoautomorphisms of Bruck loops and their generalizations
Greer, Mark
2012-01-01
We show that in a weak commutative inverse property loop, such as a Bruck loop, if $\\alpha$ is a right [left] pseudoautomorphism with companion $c$, then $c$ [$c^2$] must lie in the left nucleus. In particular, for any such loop with trivial left nucleus, every right pseudoautomorphism is an automorphism and if the squaring map is a permutation, then every left pseudoautomorphism is an automorphism as well. We also show that every pseudoautomorphism of a commutative inverse property loop is an automorphism, generalizing a well-known result of Bruck.
On Bruck Loops of 2-power Exponent
Baumeister, Barbara; Stroth, Gernot
2009-01-01
We classify "nice" loop envelopes to Bruck loops of 2-power exponent under the assumption that every nonabelian simple section of $G$ is either passive or isomorphic to $\\PSL_2(q)$, $q-1 \\ge 4$ a 2-power. The hypothesis is verified in a separate paper. This paper is a continuation of the work by Aschbacher, Kinyon and Phillips on finite Bruck loops [AKP]. In [BS3] we applied these results and get a neat description of the structure of the finite Bruck loops.
Loops with exponent three in all isotopes
Kinyon, Michael
2011-01-01
It was shown by van Rees \\cite{vR} that a latin square of order $n$ cannot have more than $n^2(n-1)/18$ latin subsquares of order 3. He conjectured that this bound is only achieved if $n$ is a power of 3. We show that it can only be achieved if $n\\equiv3\\bmod6$. We also state several conditions that are equivalent to achieving the van Rees bound. One of these is that the Cayley table of a loop achieves the van Rees bound if and only if every loop isotope has exponent 3. We call such loops \\emph{van Rees loops} and show that they form an equationally defined variety. We also show that (1) In a van Rees loop, any subloop of index 3 is normal, (2) There are exactly 6 nonassociative van Rees loops of order 27 with a non-trivial nucleus, (3) There is a Steiner quasigroup associated with every van Rees loop and (4) Every Bol loop of exponent 3 is a van Rees loop.
Polyakov loop modeling for hot QCD
Fukushima, Kenji; Skokov, Vladimir
2017-09-01
We review theoretical aspects of quantum chromodynamics (QCD) at finite temperature. The most important physical variable to characterize hot QCD is the Polyakov loop, which is an approximate order parameter for quark deconfinement in a hot gluonic medium. Additionally to its role as an order parameter, the Polyakov loop has rich physical contents in both perturbative and non-perturbative sectors. This review covers a wide range of subjects associated with the Polyakov loop from topological defects in hot QCD to model building with coupling to the Polyakov loop.
Vertically Polarized Omnidirectional Printed Slot Loop Antenna
Kammersgaard, Nikolaj Peter Iversen; Kvist, Søren H.; Thaysen, Jesper
2015-01-01
A novel vertically polarized omnidirectional printed slot loop antenna has been designed, simulated, fabricated and measured. The slot loop works as a magnetic loop. The loop is loaded with inductors to insure uniform and in-phase fields in the slot in order to obtain an omnidirectional radiation...... pattern. The antenna is designed for the 2.45 GHz Industrial, Scientific and Medical band. Applications of the antenna are many. One is for on-body applications since it is ideal for launching a creeping waves due to the polarization....
Understanding the hysteresis loop conundrum in pharmacokinetic/pharmacodynamic relationships.
Louizos, Christopher; Yáñez, Jaime A; Forrest, M Laird; Davies, Neal M
2014-01-01
Hysteresis loops are phenomena that sometimes are encountered in the analysis of pharmacokinetic and pharmacodynamic relationships spanning from pre-clinical to clinical studies. When hysteresis occurs it provides insight into the complexity of drug action and disposition that can be encountered. Hysteresis loops suggest that the relationship between drug concentration and the effect being measured is not a simple direct relationship, but may have an inherent time delay and disequilibrium, which may be the result of metabolites, the consequence of changes in pharmacodynamics or the use of a non-specific assay or may involve an indirect relationship. Counter-clockwise hysteresis has been generally defined as the process in which effect can increase with time for a given drug concentration, while in the case of clockwise hysteresis the measured effect decreases with time for a given drug concentration. Hysteresis loops can occur as a consequence of a number of different pharmacokinetic and pharmacodynamic mechanisms including tolerance, distributional delay, feedback regulation, input and output rate changes, agonistic or antagonistic active metabolites, uptake into active site, slow receptor kinetics, delayed or modified activity, time-dependent protein binding and the use of racemic drugs among other factors. In this review, each of these various causes of hysteresis loops are discussed, with incorporation of relevant examples of drugs demonstrating these relationships for illustrative purposes. Furthermore, the effect that pharmaceutical formulation has on the occurrence and potential change in direction of the hysteresis loop, and the major pharmacokinetic / pharmacodynamic modeling approaches utilized to collapse and model hysteresis are detailed.
R-loopDB: a database for R-loop forming sequences (RLFS) and R-loops
Jenjaroenpun, Piroon; Wongsurawat, Thidathip; Sutheeworapong, Sawannee; Kuznetsov, Vladimir A.
2017-01-01
R-loopDB (http://rloop.bii.a-star.edu.sg) was originally constructed as a collection of computationally predicted R-loop forming sequences (RLFSs) in the human genic regions. The renewed R-loopDB provides updates, improvements and new options, including access to recent experimental data. It includes genome-scale prediction of RLFSs for humans, six other animals and yeast. Using the extended quantitative model of RLFSs (QmRLFS), we significantly increased the number of RLFSs predicted in the human genes and identified RLFSs in other organism genomes. R-loopDB allows searching of RLFSs in the genes and in the 2 kb upstream and downstream flanking sequences of any gene. R-loopDB exploits the Ensembl gene annotation system, providing users with chromosome coordinates, sequences, gene and genomic data of the 1 565 795 RLFSs distributed in 121 056 genic or proximal gene regions of the covered organisms. It provides a comprehensive annotation of Ensembl RLFS-positive genes including 93 454 protein coding genes, 12 480 long non-coding RNA and 7 568 small non-coding RNA genes and 7 554 pseudogenes. Using new interface and genome viewers of R-loopDB, users can search the gene(s) in multiple species with keywords in a single query. R-loopDB provides tools to carry out comparative evolution and genome-scale analyses in R-loop biology. PMID:27899586
UWB communication receiver feedback loop
Spiridon, Alex; Benzel, Dave; Dowla, Farid U.; Nekoogar, Faranak; Rosenbury, Erwin T.
2007-12-04
A novel technique and structure that maximizes the extraction of information from reference pulses for UWB-TR receivers is introduced. The scheme efficiently processes an incoming signal to suppress different types of UWB as well as non-UWB interference prior to signal detection. Such a method and system adds a feedback loop mechanism to enhance the signal-to-noise ratio of reference pulses in a conventional TR receiver. Moreover, sampling the second order statistical function such as, for example, the autocorrelation function (ACF) of the received signal and matching it to the ACF samples of the original pulses for each transmitted bit provides a more robust UWB communications method and system in the presence of channel distortions.
Delay locked loop integrated circuit.
Brocato, Robert Wesley
2007-10-01
This report gives a description of the development of a Delay Locked Loop (DLL) integrated circuit (IC). The DLL was developed and tested as a stand-alone IC test chip to be integrated into a larger application specific integrated circuit (ASIC), the Quadrature Digital Waveform Synthesizer (QDWS). The purpose of the DLL is to provide a digitally programmable delay to enable synchronization between an internal system clock and external peripherals with unknown clock skew. The DLL was designed and fabricated in the IBM 8RF process, a 0.13 {micro}m CMOS process. It was designed to operate with a 300MHz clock and has been tested up to 500MHz.
Wilson loops with arbitrary charges
Korcyl, Piotr; Wosiek, Jacek
2014-01-01
We discuss how to implement, in lattice gauge theories, external charges which are not commensurate with an elementary gauge coupling. It is shown that an arbitrary, real power of a standard Wilson loop (or Polyakov line) can be defined and consistently computed in lattice formulation of non-abelian, two dimensional gauge theories. However, such an observable can excite quantum states with integer fluxes only. Since the non-integer fluxes are not in the spectrum of the theory they cannot be created, no matter which observable is chosen. Also the continuum limit of above averages does not exist unless the powers in question are in fact integer. On the other hand, a new continuum limit exists, which is rather intuitive, and where above observables make perfect sense and lead to the string tension proportional to the square of arbitrary (non necessary commensurate with gauge coupling) charge.
Li, Gang; Tang, Yi-Lei; Zhang, Chen; Zhou, Yang; Zhu, Shou-hua
2015-01-01
We construct a weakly-coupled renormalizable model to explain the 750 $\\mbox{GeV}$ diphoton excess. The 750 $\\mbox{GeV}$ resonance (denoted as $X(750)$) is interpreted as a pseudoscalar which comes from a complex singlet. The model also naturally provides a dark matter candidate. One most attractive feature of our model is that decays of $X(750)$ are all loop-induced so the diphoton rate is not diluted by unwanted tree level branching fractions. Relevant Yukawa interactions need not to be tuned to nearly non-perturbative region to explain the rate. The model is highly predictive, including the pseudoscalar nature of the new resonance, and two nearly mass-degenerate quarks carrying electric charge $5/3$ and $2/3$. In our model, rich phenomenology is expected with respect to collider searches, flavor physics and dark matter searches in various manners, if $X(750)$ can be pinned down by future LHC experiments.
Inflation and Loop Quantum Cosmology
Barrau, Aurelien
2010-01-01
On the one hand, inflation is an extremely convincing scenario: it solves most cosmological paradoxes and generates fluctuations that became the seeds for the growth of structures. It, however, suffers from a "naturalness" problem: generating initial conditions for inflation is far from easy. On the other hand, loop quantum cosmology is very successful: it solves the Big Bang singularity through a non-perturbative and background-independent quantization of general relativity. It, however, suffers from a key drawback: it is extremely difficult to test. Recent results can let us hope that inflation and LQC could mutually cure those pathologies: LQC seems to naturally generate inflation and inflation could allow us to test LQC.
Lectures on Loop Quantum Gravity
Thiemann, T
2003-01-01
Quantum General Relativity (QGR), sometimes called Loop Quantum Gravity, has matured over the past fifteen years to a mathematically rigorous candidate quantum field theory of the gravitational field. The features that distinguish it from other quantum gravity theories are 1) background independence and 2) minimality of structures. Background independence means that this is a non-perturbative approach in which one does not perturb around a given, distinguished, classical background metric, rather arbitrary fluctuations are allowed, thus precisely encoding the quantum version of Einstein's radical perception that gravity is geometry. Minimality here means that one explores the logical consequences of bringing together the two fundamental principles of modern physics, namely general covariance and quantum theory, without adding any experimentally unverified additional structures. The approach is purposely conservative in order to systematically derive which basic principles of physics have to be given up and mu...
CERN. Geneva
2016-01-01
Developing in python is fast. Computation, however, can often be another story. Or at least that is how it may seem. When working with arrays and numerical datasets one can subvert many of python’s computational limitations by utilizing numpy. Numpy is python’s standard matrix computation library. Many python users only use numpy to store and generate arrays, failing to utilize one of python’s most powerful computational tools. By leveraging numpy’s ufuncs, aggregation, broadcasting and slicing/masking/indexing functionality one can cut back on slow python loops and increase the speed of their programs by as much as 100x. This talk aims at teaching attendees how to use these tools through toy examples.
Mercier, Evan; Girodat, Dylan; Wieden, Hans-Joachim
2015-01-01
The phosphate-binding loop (P-loop) is a conserved sequence motif found in mononucleotide-binding proteins. Little is known about the structural dynamics of this region and its contribution to the observed nucleotide binding properties. Understanding the underlying design principles is of great interest for biomolecular engineering applications. We have used rapid-kinetics measurements in vitro and molecular dynamics (MD) simulations in silico to investigate the relationship between GTP-binding properties and P-loop structural dynamics in the universally conserved Elongation Factor (EF) Tu. Analysis of wild type EF-Tu and variants with substitutions at positions in or adjacent to the P-loop revealed a correlation between P-loop flexibility and the entropy of activation for GTP dissociation. The same variants demonstrate more backbone flexibility in two N-terminal amino acids of the P-loop during force-induced EF-Tu·GTP dissociation in Steered Molecular Dynamics simulations. Amino acids Gly18 and His19 are involved in stabilizing the P-loop backbone via interactions with the adjacent helix C. We propose that these P-loop/helix C interactions function as a conserved P-loop anchoring module and identify the presence of P-loop anchors within several GTPases and ATPases suggesting their evolutionary conservation. PMID:25566871
Mercier, Evan; Girodat, Dylan; Wieden, Hans-Joachim
2015-01-01
The phosphate-binding loop (P-loop) is a conserved sequence motif found in mononucleotide-binding proteins. Little is known about the structural dynamics of this region and its contribution to the observed nucleotide binding properties. Understanding the underlying design principles is of great interest for biomolecular engineering applications. We have used rapid-kinetics measurements in vitro and molecular dynamics (MD) simulations in silico to investigate the relationship between GTP-binding properties and P-loop structural dynamics in the universally conserved Elongation Factor (EF) Tu. Analysis of wild type EF-Tu and variants with substitutions at positions in or adjacent to the P-loop revealed a correlation between P-loop flexibility and the entropy of activation for GTP dissociation. The same variants demonstrate more backbone flexibility in two N-terminal amino acids of the P-loop during force-induced EF-Tu.GTP dissociation in Steered Molecular Dynamics simulations. Amino acids Gly18 and His19 are involved in stabilizing the P-loop backbone via interactions with the adjacent helix C. We propose that these P-loop/helix C interactions function as a conserved P-loop anchoring module and identify the presence of P-loop anchors within several GTPases and ATPases suggesting their evolutionary conservation.
On the Properties of Cosmic String Loops
Casper, Paul Henry
1996-01-01
When coupled with the prevailing ideas of cosmology, the standard model of particle physics implies that the early universe underwent a sequence of phase transitions. Such phase transitions can lead to topological defects such as magnetic monopoles, domain walls and cosmic strings. The formation and subsequent evolution of a network of cosmic strings may have played a key role in the development of the early universe. One of the most crucial elements in the evolution of the cosmic string network is the formation and decay of closed loops of cosmic string. After formation, the loops lose their energy by emitting gravitational radiation. This provides the primary energy loss mechanism for the cosmic string network. In addition, the cosmic string loops may display a number of observable features through which the cosmic string model may be constrained. In this dissertation a number of the key properties of cosmic string loops are investigated. A general method for determining the rates at which cosmic string loops radiate both energy and linear momentum is developed and implemented. Exact solutions for the radiation rates of a several new classes of loops are derived and used to test the validity of using the piecewise linear method on smooth loop trajectories. A large set of representative loop trajectories is produced using the method of loop fragmentation. These trajectories are analyzed to provide useful information on the properties of realistic cosmic string loops. The fraction of cosmic string loops which would collapse to form black holes is determined and used to place a new observational limit on the mass per unit length of cosmic strings.
One Loop Mass Renormalization of Unstable Particles in Superstring Theory
Sen, Ashoke
2016-01-01
Most of the massive states in superstring theory are expected to undergo mass renormalization at one loop order. Typically these corrections should contain imaginary parts, indicating that the states are unstable against decay into lighter particles. However in such cases, direct computation of the renormalized mass using superstring perturbation theory yields divergent result. Previous approaches to this problem involve various analytic continuation techniques, or deforming the integral over the moduli space of the torus with two punctures into the complexified moduli space near the boundary. In this paper we use insights from string field theory to describe a different approach that gives manifestly finite result for the mass shift satisfying unitarity relations. The procedure is applicable to all states of (compactified) type II and heterotic string theories. We illustrate this by computing the one loop correction to the mass of the first massive state on the leading Regge trajectory in SO(32) heterotic st...
Systematics of the Multi-Regge Three-Loop Symbol
Bargheer, Till
2016-01-01
We review the systematics of Mandelstam cut contributions to planar scattering amplitudes in the multi-Regge limit. Isolating the relevant cut terms, we explain how the BFKL expansion can be used to construct the perturbative n-point MHV multi-Regge limit symbol from a finite number of basic building blocks. At three loops and at leading logarithmic order, two building blocks are required. These are extracted from the known three-loop six-point and seven-point symbols for general kinematics. The subleading and sub-subleading terms require two and one further building block, respectively. The latter could either be reconstructed from further perturbative data, or from BFKL integrals involving yet-unknown corrections to the central emission vertex, on whose construction we also briefly comment.
Geometric Structures on Loop and Path Spaces
Vicente Muñoz; Francisco Presas
2010-09-01
The loop space associated to a Riemannian manifold admits a quasi-symplectic structure (that is, a closed 2-form which is non-degenerate up to a finite-dimensional kernel). We show how to construct a compatible almost-complex structure. Finally conditions to have contact structures on loop spaces are studied.
Holonomy loops, spectral triples and quantum gravity
Johannes, Aastrup; Grimstrup, Jesper Møller; Nest, Ryszard
2009-01-01
We review the motivation, construction and physical interpretation of a semi-finite spectral triple obtained through a rearrangement of central elements of loop quantum gravity. The triple is based on a countable set of oriented graphs and the algebra consists of generalized holonomy loops...
Newtonian gravity in loop quantum gravity
Smolin, Lee
2010-01-01
We apply a recent argument of Verlinde to loop quantum gravity, to conclude that Newton's law of gravity emerges in an appropriate limit and setting. This is possible because the relationship between area and entropy is realized in loop quantum gravity when boundaries are imposed on a quantum spacetime.
Formation of Chromosomal Domains by Loop Extrusion
Geoffrey Fudenberg
2016-05-01
Full Text Available Topologically associating domains (TADs are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely cohesins, form progressively larger loops but stall at TAD boundaries due to interactions with boundary proteins, including CTCF. Using polymer simulations, we show that this model produces TADs and finer-scale features of Hi-C data. Each TAD emerges from multiple loops dynamically formed through extrusion, contrary to typical illustrations of single static loops. Loop extrusion both explains diverse experimental observations—including the preferential orientation of CTCF motifs, enrichments of architectural proteins at TAD boundaries, and boundary deletion experiments—and makes specific predictions for the depletion of CTCF versus cohesin. Finally, loop extrusion has potentially far-ranging consequences for processes such as enhancer-promoter interactions, orientation-specific chromosomal looping, and compaction of mitotic chromosomes.
High-Order Frequency-Locked Loops
Golestan, Saeed; Guerrero, Josep M.; Quintero, Juan Carlos Vasquez
2017-01-01
In very recent years, some attempts for designing high-order frequency-locked loops (FLLs) have been made. Nevertheless, the advantages and disadvantages of these structures, particularly in comparison with a standard FLL and high-order phase-locked loops (PLLs), are rather unclear. This lack......) as well as a unification between FLLs and PLLs is presented....
Conformal anomaly of super Wilson loop
Belitsky, A.V., E-mail: andrei.belitsky@asu.edu [Department of Physics, Arizona State University, Tempe, AZ 85287-1504 (United States)
2012-09-11
Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in conformal theories when one uses dimensional regularization. The rotation matrix to the diagonal basis is found by means of computing the anomaly in the Ward identity for the conformal boost. Presently, we apply this ideology to the super Wilson loop. We compute the one-loop conformal anomaly for the super Wilson loop and find that the anomaly depends on its Grassmann coordinates. By subtracting this anomalous contribution from the super Wilson loop we restore its interpretation as a dual description for reduced non-MHV amplitudes which are expressed in terms of superconformal invariants.
Design Principles for Closed Loop Supply Chains
H.R. Krikke (Harold); C.P. Pappis (Costas); G.T. Tsoulfas; J.M. Bloemhof-Ruwaard (Jacqueline)
2001-01-01
textabstractIn this paper we study design principles for closed loop supply chains. Closed loop supply chains aim at closing material flows thereby limiting emission and residual waste, but also providing customer service at low cost. We study 'traditional' and 'new' design principles known in the l
Loop approaches to gauge field theory
Loll, R.
1992-01-01
Basic mathematical and physical concepts in loop- and path-dependent formulations of Yang-MiIls theory are reviewed and set into correspondence. We point out some problems peculiar to these non-local approaches, in particular those associated with defining structure on various kinds of loop
External Tank CIL Closed Loop Verification System
Hartley, Eugene A., Jr.
2005-01-01
Lockheed Martin was requested to develop a closed loop CIL system following the Challenger accident. The system that was developed has proven to be very robust with minimal problems since implementation, having zero escapes in the last 7 years (27 External Tanks). We are currently investigating expansion of the CIL Closed Loop system to include "MI" CILs.
New Matrix Loop Algebra and Its Application
DONG Huan-He; XU Yue-Cai
2008-01-01
A new matrix Lie algebra and its corresponding Loop algebra are constructed firstly, as its appfication, the multi-component TC equation hierarchy is obtained, then by use of trace identity the Hamiltonian structure of the above system is presented. Finally, the integrable couplings of the obtained system is worked out by the expanding matrix Loop algebra.
Complete renormalization of QCD at five loops
Luthe, Thomas; Maier, Andreas; Marquard, Peter; Schröder, York
2017-03-01
We present new analytical five-loop Feynman-gauge results for the anomalous dimensions of ghost field and -vertex, generalizing the known values for SU(3) to a general gauge group. Together with previously published results on the quark mass and -field anomalous dimensions and the Beta function, this completes the 5-loop renormalization program of gauge theories in that gauge.
Newtonian gravity in loop quantum gravity
Smolin, Lee
2010-01-01
We apply a recent argument of Verlinde to loop quantum gravity, to conclude that Newton's law of gravity emerges in an appropriate limit and setting. This is possible because the relationship between area and entropy is realized in loop quantum gravity when boundaries are imposed on a quantum spacetime.
Design Principles for Closed Loop Supply Chains
H.R. Krikke (Harold); C.P. Pappis (Costas); G.T. Tsoulfas; J.M. Bloemhof-Ruwaard (Jacqueline)
2001-01-01
textabstractIn this paper we study design principles for closed loop supply chains. Closed loop supply chains aim at closing material flows thereby limiting emission and residual waste, but also providing customer service at low cost. We study 'traditional' and 'new' design principles known in the
Structural studies on an internal loop from a hairpin ribozyme
Cai, Z.; SantaLucia, J. Jr.; Tinoco, I. Jr. [Univ. of California, Berkeley, CA (United States)
1994-12-01
Ribozymes, RNA enzymes, catalyze site-specific RNA cleavage and ligation reactions. We are studying the three-dimensional structure of a hairpin ribozyme derived from the minus strand of tobacco ring spot virus satellite RNA ((-)sTRSV), which has been engineering to specifically cleave the HIV-1 RNA. The minimum structure for the catalytic reaction involves a 50-nucleotide ribozyme and a 14-nucleotide substrate. The proposed secondary structure of the ribozyme-substrate complex consists of four short helices separated by two internal loops. The relatively large size (64-nucleotide) of the ribozyme-substrate complex presents formidable problems in solving the structure using NMR. Therefore we are studying smaller structural subunits of the complex. We are determining the high resolution structure of the symmetric internal loop involving the cleavage site and the flanking helices. One strand of the internal loop was selectively {sup 13}C-labeled at C8 of each purine and C6 of each pyrimidine. By using {sup 13}C-edited two-dimensional NMR, the proton NOESY spectrum was greatly simplified. This allowed unambiguous sequential proton resonance assignments along each strand. Three-dimensional {sup 1}-{sup 13}C HMQC-NOESY was used to further facilitate resonance assignments. We are also enzymatically synthesizing the entire 50-nucleotide ribozyme and will combine it with the {sup 13}C-labeled substrate. Through comparison of the NOE connectivities of the labeled nucleotides from the internal loop alone with those from the entire complex, the differences between the two structures can be elucidated.
Engineering magnetic nanostructures with inverse hysteresis loops
Beatriz Mora; Nastassia Soriano; Carolina Redondo; Alberto Arteche; David Navas; Rafael Morales
2016-01-01
Top-down lithography techniques allow the fabrication of nanostructured elements with novel spin configurations,which provide a new route to engineer and manipulate the magnetic response of sensors and electronic devices and understand the role of fundamental interactions in materials science.In this study, shallow nanostructure-pattemed thin films were designed to present inverse magnetization curves,i.e.,an anomalous magnetic mechanism characterized by a negative coercivity and negative remanence.This procedure involved a method for manipulating the spin configuration that yielded a negative coercivity after the patterning of a single material layer.Patterned NiFe thin films with trench depths between 15％-25％ of the total film thickness exhibited inverse hysteresis loops for a wide angular range of the applied field and the trench axis.A model based on two exchange-coupled subsystems accounts for the experimental results and thus predicts the conditions for the appearance of this magnetic behavior.The findings of the study not only advance our understanding of patterning effects and confined magnetic systems but also enable the local design and control of the magnetic response of thin materials with potential use in sensor engineering.
Loop corrections to the antibrane potential
Bena, Iosif; Blåbäck, Johan; Turton, David
2016-07-01
Antibranes provide some of the most generic ways to uplift Anti-de Sitter flux compactifications to de Sitter, and there is a growing body of evidence that antibranes placed in long warped throats such as the Klebanov-Strassler warped deformed conifold solution have a brane-brane-repelling tachyon. This tachyon was first found in the regime of parameters in which the backreaction of the antibranes is large, and its existence was inferred from a highly nontrivial cancellation of certain terms in the inter-brane potential. We use a brane effective action approach, similar to that proposed by Michel, Mintun, Polchinski, Puhm and Saad in [29], to analyze antibranes in Klebanov-Strassler when their backreaction is small, and find a regime of parameters where all perturbative contributions to the action can be computed explicitly. We find that the cancellation found at strong coupling is also present in the weak-coupling regime, and we establish its existence to all loops. Our calculation indicates that the spectrum of the antibrane worldvolume theory is not gapped, and may generically have a tachyon. Hence uplifting mechanisms involving antibranes remain questionable even when backreaction is small.
Feedback Loop Gains and Feedback Behavior (1996)
Kampmann, Christian Erik
2012-01-01
Linking feedback loops and system behavior is part of the foundation of system dynamics, yet the lack of formal tools has so far prevented a systematic application of the concept, except for very simple systems. Having such tools at their disposal would be a great help to analysts in understanding...... large, complicated simulation models. The paper applies tools from graph theory formally linking individual feedback loop strengths to the system eigenvalues. The significance of a link or a loop gain and an eigenvalue can be expressed in the eigenvalue elasticity, i.e., the relative change...... of an eigenvalue resulting from a relative change in the gain. The elasticities of individual links and loops may be found through simple matrix operations on the linearized system. Even though the number of feedback loops can grow rapidly with system size, reaching astronomical proportions even for modest systems...
Damped transverse oscillations of interacting coronal loops
Soler, Roberto
2015-01-01
Damped transverse oscillations of magnetic loops are routinely observed in the solar corona. This phenomenon is interpreted as standing kink magnetohydrodynamic waves, which are damped by resonant absorption owing to plasma inhomogeneity across the magnetic field. The periods and damping times of these oscillations can be used to probe the physical conditions of the coronal medium. Some observations suggest that interaction between neighboring oscillating loops in an active region may be important and can modify the properties of the oscillations compared to those of an isolated loop. Here we theoretically investigate resonantly damped transverse oscillations of interacting non-uniform coronal loops. We provide a semi-analytic method, based on the T-matrix theory of scattering, to compute the frequencies and damping rates of collective oscillations of an arbitrary configuration of parallel cylindrical loops. The effect of resonant damping is included in the T-matrix scheme in the thin boundary approximation. ...
Dynamic Model of Gap Loop for HCW Mill
YANG Jing-ming; YANG Qiu-xia; CHE Hai-jun; CHANG Ling-fang
2004-01-01
The hydraulic automatic gauge control system using gap loop for cold mill was designed. The stiffness of HCW cold mill was defined for gap loop, and the dynamic model of gauge control system for gap loop was built with mechanism analysis. The stiffness for gap loop and the cylinder displacement loop were measured.
Direct loop gain and bandwidth measurement of phase-locked loop
Ye, P.; Ren, R.; Kou, Y.; Sun, F.; Hu, J.; Chen, S.; Hou, D.
2017-08-01
A simple and robust technique for directly measuring the loop gain and bandwidth of a phase-locked loop (PLL) is proposed. This technique can be used for the real-time measurement of the real loop gain in a closed PLL without breaking its locking state. The agreement of the measured loop gain and theoretical calculations proves the validity of the proposed measurement technique. This technique with a simple configuration can be easily expanded to other phase-locking systems whose loop gain and bandwidth should be measured precisely.
Liu, Zhen
2016-01-01
We extend some two Higgs doublet models, where the Yukawa couplings for the charged fermion mass generation only involve one Higgs doublet, by two singlet scalars respectively carrying a singly electric charge and a doubly electric charge. The doublet and singlet scalars together can mediate a two-loop diagram to generate a tiny Majorana mass matrix of the standard model neutrinos. Remarkably, the structure of the neutrino mass matrix is fully determined by the symmetric Yukawa couplings of the doubly charged scalar to the right-handed leptons. Meanwhile, a one-loop induced neutrinoless double beta decay can arrive at a testable level even if the electron neutrino has an extremely small Majorana mass. We also study other experimental constraints and implications including some rare processes and Higgs phenomenology.
Zhen Liu
2017-02-01
Full Text Available We extend some two Higgs doublet models, where the Yukawa couplings for the charged fermion mass generation only involve one Higgs doublet, by two singlet scalars respectively carrying a singly electric charge and a doubly electric charge. The doublet and singlet scalars together can mediate a two-loop diagram to generate a tiny Majorana mass matrix of the standard model neutrinos. Remarkably, the structure of the neutrino mass matrix is fully determined by the symmetric Yukawa couplings of the doubly charged scalar to the right-handed leptons. Meanwhile, a one-loop induced neutrinoless double beta decay can arrive at a testable level even if the electron neutrino has an extremely small Majorana mass. We also study other experimental constraints and implications including some rare processes and Higgs phenomenology.
Liu, Zhen; Gu, Pei-Hong
2017-02-01
We extend some two Higgs doublet models, where the Yukawa couplings for the charged fermion mass generation only involve one Higgs doublet, by two singlet scalars respectively carrying a singly electric charge and a doubly electric charge. The doublet and singlet scalars together can mediate a two-loop diagram to generate a tiny Majorana mass matrix of the standard model neutrinos. Remarkably, the structure of the neutrino mass matrix is fully determined by the symmetric Yukawa couplings of the doubly charged scalar to the right-handed leptons. Meanwhile, a one-loop induced neutrinoless double beta decay can arrive at a testable level even if the electron neutrino has an extremely small Majorana mass. We also study other experimental constraints and implications including some rare processes and Higgs phenomenology.
Cygnus Loop Supernova Blast Wave
1993-01-01
This is an image of a small portion of the Cygnus Loop supernova remnant, which marks the edge of a bubble-like, expanding blast wave from a colossal stellar explosion, occurring about 15,000 years ago. The HST image shows the structure behind the shock waves, allowing astronomers for the first time to directly compare the actual structure of the shock with theoretical model calculations. Besides supernova remnants, these shock models are important in understanding a wide range of astrophysical phenomena, from winds in newly-formed stars to cataclysmic stellar outbursts. The supernova blast is slamming into tenuous clouds of insterstellar gas. This collision heats and compresses the gas, causing it to glow. The shock thus acts as a searchlight revealing the structure of the interstellar medium. The detailed HST image shows the blast wave overrunning dense clumps of gas, which despite HST's high resolution, cannot be resolved. This means that the clumps of gas must be small enough to fit inside our solar system, making them relatively small structures by interstellar standards. A bluish ribbon of light stretching left to right across the picture might be a knot of gas ejected by the supernova; this interstellar 'bullet' traveling over three million miles per hour (5 million kilometres) is just catching up with the shock front, which has slowed down by ploughing into interstellar material. The Cygnus Loop appears as a faint ring of glowing gases about three degrees across (six times the diameter of the full Moon), located in the northern constellation, Cygnus the Swan. The supernova remnant is within the plane of our Milky Way galaxy and is 2,600 light-years away. The photo is a combination of separate images taken in three colors, oxygen atoms (blue) emit light at temperatures of 30,000 to 60,000 degrees Celsius (50,000 to 100,000 degrees Farenheit). Hydrogen atoms (green) arise throughout the region of shocked gas. Sulfur atoms (red) form when the gas cools to
Loop Staggering,Loop Compacting：Restructuring Techniques for Thrashing Problem
金国华; 杨学军; 等
1993-01-01
Parallel loops account for the greatest amount of parallelism in numerical programs.Executing nested loops in parallel wit low run-time overhead is thus very important for achieving high performance in paralleo processing systems.However,in parallel processing systems with caches of local memories in memory hierarchies,“thrashing problemmay” may arise when data move back and forth frequently between the caches or local memories in different processors.The techniques associated with parallel compiler to solve the problem are not completely developed.In this paper,we present two restructuring techniques called loopg staggering,loop staggering and compacting,with which we can not only eliminate the cache or local memory thrashing phemomena significantly,but also exploit the potential parallelism existing in outer serial loop.Loop staggering benefits the dynamic loop scheduling strategies,whereas loop staggering and compacting is good for static loop scheduling strategies,Our method especially benefits parallel programs,in which a parallel loop is enclosed by a serial loop and array elements are repeatedly used in the different iterations of the parallel loop.
Electron contribution to the muon anomalous magnetic moment at four loops
Kurz, Alexander; Marquard, Peter; Smirnov, Alexander; Smirnov, Vladimir; Steinhauser, Matthias
2016-01-01
We present results for the QED contributions to the anomalous magnetic moment of the muon containing closed electron loops. The main focus is on perturbative corrections at four-loop order where the external photon couples to the external muon. Furthermore, all four-loop contributions involving simultaneously a closed electron and tau loop are computed. In combination with our recent results on the light-by-light-type corrections (see Ref. \\cite{Kurz:2015bia}) the complete four-loop electron-loop contribution to the anomalous magnetic moment of the muon has been obtained with an independent calculation. Our calculation is based on an asymptotic expansion in the ratio of the electron and the muon mass and shows the importance of higher order terms in this ratio. We perform a detailed comparison with results available in the literature and find good numerical agreement. As a by-product we present analytic results for the on-shell muon mass and wave function renormalization constants at three-loop order includin...
Numerical characterization of heat transfer in closed-loop vertical ground heat exchanger
Chulho; LEE; Hujeong; GIL; Hangseok; CHOI; Shin-Hyung; KANG
2010-01-01
A series of numerical analyses has been performed on the characteristics of heat transfer in a closed-loop vertical ground heat exchanger(U-loop).A 2-D finite element analysis was conducted to evaluate the temperature distribution over the cross section of the U-loop system involving high-density polyethylene(HDPE) pipe/grout/soil to compare the sectional efficiency between the conventional U-loop and a new latticed HDPE pipe system,which is equipped with a thermally insulating lattice in order to reduce thermal interference between the inlet and outlet pipes.In addition,a 3-D finite volume analysis(FLUENT) was adopted to simulate the operation of the closed-loop vertical ground heat exchanger with the consideration of the effect of a distance between the inlet and outlet pipes,grout’s thermal properties,the effectiveness of the latticed HDPE pipe system,and the rate of circulation pump.It was observed that the thermal interference between the two strands of U-loop is of importance in enhancing efficiency of the ground heat exchanger.Consequently,it is recommended to modify the configuration of the conventional U-loop system by equipping the thermally insulating lattice between the two pipe strands.
State refinements and coarse graining in a full theory embedding of loop quantum cosmology
Bodendorfer, N.
2017-07-01
Bridging between descriptions involving few large and many small quantum numbers is the main open problem in loop quantum gravity. In other words, one would like to be able to represent the same physical system in terms of a few ‘coarse’ quantum numbers, while the effective dynamics at the coarse level should agree with the one induced by a description involving many small quantum numbers. Efforts to understand this relationship face the problem of the enormous computational complexity involved in evolving a generic state containing many quanta. In a cosmological context however, certain symmetry assumptions on the quantum states allow one to simplify the problem. In this paper, we will show how quantum states describing a spatially flat homogeneous and isotropic universe can be refined and coarse grained. Invariance of the dynamics of the coarse observables is shown to require a certain scaling property (familiar from loop quantum cosmology) of the quantum states if no running of parameters is taken into account. The involved states are solutions to the Hamiltonian constraint when terms coming from spatial derivatives are neglected, i.e. one works in the approximation of non-interacting FRW patches. The technical means to arrive at this result are a version of loop quantum gravity based on variables inspired by loop quantum cosmology, as well as an exact solution to the quantum dynamics of loop quantum cosmology which extends to the full theory in the chosen approximation.
Loops in exceptional field theory
Bossard, Guillaume [Centre de Physique Théorique, Ecole Polytechnique, CNRS, Université Paris-Saclay,91128 Palaiseau cedex (France); Kleinschmidt, Axel [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut),Am Mühlenberg 1, DE-14476 Potsdam (Germany); International Solvay Institutes,ULB-Campus Plaine CP231, BE-1050 Brussels (Belgium)
2016-01-27
We study certain four-graviton amplitudes in exceptional field theory in dimensions D≥4 up to two loops. As the formulation is manifestly invariant under the U-duality group E{sub 11−D}(ℤ), our resulting expressions can be expressed in terms of automorphic forms. In the low energy expansion, we find terms in the M-theory effective action of type R{sup 4}, ∇{sup 4}R{sup 4} and ∇{sup 6}R{sup 4} with automorphic coefficient functions in agreement with independent derivations from string theory. This provides in particular an explicit integral formula for the exact string theory ∇{sup 6}R{sup 4} threshold function. We exhibit moreover that the usual supergravity logarithmic divergences cancel out in the full exceptional field theory amplitude, within an appropriately defined dimensional regularisation scheme. We also comment on terms of higher derivative order and the role of the section constraint for possible counterterms.
Analysis and improvement of missile three-loop autopilots
Lin Defu; Fan Junfang; Qi Zaikang; Mou Yu
2009-01-01
characteristics from a two-loop autopilot with PI compensator.Both the two-loop and three-loop topologies can stabilize a static unstable missile.However,the finite actuator resource is the crucial factor dominating autopilot function.
Coronal loop detection and salient contour group extraction from solar images
Durak, Nurcan
2011-01-01
This dissertation addresses two different problems: 1) coronal loop detection from solar images: and 2) salient contour group extraction from cluttered images. In the first part, we propose two different solutions to the coronal loop detection problem. The first solution is a block-based coronal loop mining method that detects coronal loops from solar images by dividing the solar image into fixed sized blocks, labeling the blocks as "Loop" or "Non-Loop", extracting features from the labeled blocks, and finally training classifiers to generate learning models that can classify new image blocks. The block-based approach achieves 64% accuracy in 10-fold cross validation experiments. To improve the accuracy and scalability, we propose a contour-based coronal loop detection method that extracts contours from cluttered regions, then labels the contours as "Loop" and "Non-Loop", and extracts geometric features from the labeled contours. The contour-based approach achieves 85% accuracy in 10-fold cross validation experiments, which is a 20% increase compared to the block-based approach. In the second part, we propose a method to extract semi-elliptical open curves from cluttered regions. Our method consists of the following steps: obtaining individual smooth contours along with their saliency measures; then starting from the most salient contour, searching for possible grouping options for each contour; and continuing the grouping until an optimum solution is reached. Our work involved the design and development of a complete system for coronal loop mining in solar images, which required the formulation of new Gestalt perceptual rules and a systematic methodology to select and combine them in a fully automated judicious manner using machine learning techniques that eliminate the need to manually set various weight and threshold values to define an effective cost function. After finding salient contour groups, we close the gaps within the contours in each group and perform
Mitotic chromosome compaction via active loop extrusion
Goloborodko, Anton; Imakaev, Maxim; Marko, John; Mirny, Leonid; MIT-Northwestern Team
During cell division, two copies of each chromosome are segregated from each other and compacted more than hundred-fold into the canonical X-shaped structures. According to earlier microscopic observations and the recent Hi-C study, chromosomes are compacted into arrays of consecutive loops of ~100 kilobases. Mechanisms that lead to formation of such loop arrays are largely unknown. Here we propose that, during cell division, chromosomes can be compacted by enzymes that extrude loops on chromatin fibers. First, we use computer simulations and analytical modeling to show that a system of loop-extruding enzymes on a chromatin fiber self-organizes into an array of consecutive dynamic loops. Second, we model the process of loop extrusion in 3D and show that, coupled with the topo II strand-passing activity, it leads to robust compaction and segregation of sister chromatids. This mechanism of chromosomal condensation and segregation does not require additional proteins or specific DNA markup and is robust against variations in the number and properties of such loop extruding enzymes. Work at NU was supported by the NSF through Grants DMR-1206868 and MCB-1022117, and by the NIH through Grants GM105847 and CA193419. Work at MIT was supported by the NIH through Grants GM114190 R01HG003143.
Construction of the blowdown and condensation loop
Park, Choon Kyung; Song, Chul Kyung; Cho, Seok; Chun, S. Y.; Chung, Moon Ki
1997-12-01
The blowdown and condensation loop (B and C loop) has been constructed to get experimental data for designing the safety depressurization system (SDS) and steam sparger which are considered to implement in the Korea Next Generation Reactor (KNGR). In this report, system description on the B and C loop is given in detail, which includes the drawings and technical specification of each component, instrumentation and control system, and the operational procedures and the results of the performance testing. (author). 7 refs., 11 tabs., 48 figs.
Parallel Digital Phase-Locked Loops
Sadr, Ramin; Shah, Biren N.; Hinedi, Sami M.
1995-01-01
Wide-band microwave receivers of proposed type include digital phase-locked loops in which band-pass filtering and down-conversion of input signals implemented by banks of multirate digital filters operating in parallel. Called "parallel digital phase-locked loops" to distinguish them from other digital phase-locked loops. Systems conceived as cost-effective solution to problem of filtering signals at high sampling rates needed to accommodate wide input frequency bands. Each of M filters process 1/M of spectrum of signal.
Loop-deformed Poincar\\'e algebra
Mielczarek, Jakub
2013-01-01
In this essay we present evidence suggesting that loop quantum gravity leads to deformation of the local Poincar\\'e algebra within the limit of high energies. This deformation is a consequence of quantum modification of effective off-shell hypersurface deformation algebra. Surprisingly, the form of deformation suggests that the signature of space-time changes from Lorentzian to Euclidean at large curvatures. We construct particular realization of the loop-deformed Poincar\\'e algebra and find that it can be related to curved momentum space, which indicates the relationship with recently introduced notion of relative locality. The presented findings open a new way of testing loop quantum gravity effects.
Spin-2 Form Factors at Three Loop in QCD
Ahmed, Taushif; Mathews, Prakash; Rana, Narayan; Ravindran, V
2015-01-01
Spin-2 fields are often candidates in physics beyond the Standard Model namely the models with extra-dimensions where spin-2 Kaluza-Klein gravitons couple to the fields of the SM. Also, in the context of Higgs searches, spin-2 fields have been studied as an alternative to the scalar Higgs boson. In this article, we present the complete three loop QCD radiative corrections to the spin-2 quark-antiquark and spin-2 gluon-gluon form factors in SU(N) gauge theory with $n_f$ light flavors. These form factors contribute to both quark-antiquark and gluon-gluon initiated processes involving spin-2 particle in the hadronic reactions at the LHC. We have studied the structure of infrared singularities in these form factors up to three loop level using Sudakov integro-differential equation and found that the anomalous dimensions originating from soft and collinear regions of the loop integrals coincide with those of the electroweak vector boson and Higgs form factors confirming the universality of the infrared singulariti...
Bootstrapping One-Loop QCD Amplitudeswith General Helicities
Berger, Carola F.; Bern, Zvi; Dixon, Lance J.; Forde, Darren; Kosower, David A.
2006-04-25
The recently developed on-shell bootstrap for computing one-loop amplitudes in non-supersymmetric theories such as QCD combines the unitarity method with loop-level on-shell recursion. For generic helicity configurations, the recursion relations may involve undetermined contributions from non-standard complex singularities or from large values of the shift parameter. Here we develop a strategy for sidestepping difficulties through use of pairs of recursion relations. To illustrate the strategy, we present sets of recursion relations needed for obtaining n-gluon amplitudes in QCD. We give a recursive solution for the one-loop n-gluon QCD amplitudes with three or four color-adjacent gluons of negative helicity and the remaining ones of positive helicity. We provide an explicit analytic formula for the QCD amplitude A{sub 6;1}(1{sup -}, 2{sup -}, 3{sup -}, 4{sup +}, 5{sup +}, 6{sup +}), as well as numerical results for A{sub 7;1}(1{sup -}, 2{sup -}, 3{sup -}, 4{sup +}, 5{sup +}, 6{sup +}, 7{sup +}), A{sub 8;1}(1{sup -}, 2{sup -}, 3{sup -}, 4{sup +}, 5{sup +}, 6{sup +}, 7{sup +}, 8{sup +}), and A{sub 8;1}(1{sup -}, 2{sup -}, 3{sup -}, 4{sup -}, 5{sup +}, 6{sup +}, 7{sup +}, 8{sup +}). We expect the on-shell bootstrap approach to have widespread applications to phenomenological studies at colliders.
Spin-2 form factors at three loop in QCD
Ahmed, Taushif; Das, Goutam; Mathews, Prakash; Rana, Narayan; Ravindran, V.
2015-12-01
Spin-2 fields are often candidates in physics beyond the Standard Model namely the models with extra-dimensions where spin-2 Kaluza-Klein gravitons couple to the fields of the Standard Model. Also, in the context of Higgs searches, spin-2 fields have been studied as an alternative to the scalar Higgs boson. In this article, we present the complete three loop QCD radiative corrections to the spin-2 quark-antiquark and spin-2 gluon-gluon form factors in SU(N) gauge theory with n f light flavors. These form factors contribute to both quark-antiquark and gluon-gluon initiated processes involving spin-2 particle in the hadronic reactions at the LHC. We have studied the structure of infrared singularities in these form factors up to three loop level using Sudakov integro-differential equation and found that the anomalous dimensions originating from soft and collinear regions of the loop integrals coincide with those of the electroweak vector boson and Higgs form factors confirming the universality of the infrared singularities in QCD amplitudes.
Comparison of oxygen carriers for chemical-looping combustion
Johansson Marcus
2006-01-01
Full Text Available Chemical-looping combustion is a combustion technology with inherent separation of the greenhouse gas CO2. This technique involves combustion of fossil fuels by means of an oxygen carrier which transfers oxygen from the air to the fuel. In this manner a decrease in efficiency is avoided for the energy demanding separation of CO2 from the rest of the flue gases. Results from fifty oxygen carriers based on iron-, manganese- and nickel oxides on different inert materials are compared. The particles were prepared using freeze granulation, sintered at different temperatures and sieved to a size 125-180 mm. To simulate the environment the particles would be exposed to in a chemical-looping combustor, reactivity tests under alternating oxidizing and reducing conditions were performed in a laboratory fluidized bed-reactor of quartz. Reduction was performed in 50% CH4/50% H2O while the oxidation was carried out in 5% O2 in nitrogen. In general nickel particles are the most reactive, followed by manganese. Iron particles are harder but have a lower reactivity. An increase in sintering temperatures normally leads to an increase in strength and decrease in reactivity. Several particles investigated display a combination of high reactivity and strength as well as good fluidization behavior, and are feasible for use as oxygen carriers in chemical-looping combustion.
Spin-2 form factors at three loop in QCD
Ahmed, Taushif [The Institute of Mathematical Sciences,IV Cross Road, CIT Campus, Chennai 600 113 (India); Das, Goutam; Mathews, Prakash [Saha Institute of Nuclear Physics,1/AF Bidhan Nagar, Kolkata 700 064 (India); Rana, Narayan; Ravindran, V. [The Institute of Mathematical Sciences,IV Cross Road, CIT Campus, Chennai 600 113 (India)
2015-12-15
Spin-2 fields are often candidates in physics beyond the Standard Model namely the models with extra-dimensions where spin-2 Kaluza-Klein gravitons couple to the fields of the Standard Model. Also, in the context of Higgs searches, spin-2 fields have been studied as an alternative to the scalar Higgs boson. In this article, we present the complete three loop QCD radiative corrections to the spin-2 quark-antiquark and spin-2 gluon-gluon form factors in SU(N) gauge theory with n{sub f} light flavors. These form factors contribute to both quark-antiquark and gluon-gluon initiated processes involving spin-2 particle in the hadronic reactions at the LHC. We have studied the structure of infrared singularities in these form factors up to three loop level using Sudakov integro-differential equation and found that the anomalous dimensions originating from soft and collinear regions of the loop integrals coincide with those of the electroweak vector boson and Higgs form factors confirming the universality of the infrared singularities in QCD amplitudes.
Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.
Hu, Jiazhi; Zhang, Yu; Zhao, Lijuan; Frock, Richard L; Du, Zhou; Meyers, Robin M; Meng, Fei-long; Schatz, David G; Alt, Frederick W
2015-11-05
RAG initiates antibody V(D)J recombination in developing lymphocytes by generating "on-target" DNA breaks at matched pairs of bona fide recombination signal sequences (RSSs). We employ bait RAG-generated breaks in endogenous or ectopically inserted RSS pairs to identify huge numbers of RAG "off-target" breaks. Such breaks occur at the simple CAC motif that defines the RSS cleavage site and are largely confined within convergent CTCF-binding element (CBE)-flanked loop domains containing bait RSS pairs. Marked orientation dependence of RAG off-target activity within loops spanning up to 2 megabases implies involvement of linear tracking. In this regard, major RAG off-targets in chromosomal translocations occur as convergent RSS pairs at enhancers within a loop. Finally, deletion of a CBE-based IgH locus element disrupts V(D)J recombination domains and, correspondingly, alters RAG on- and off-target distributions within IgH. Our findings reveal how RAG activity is developmentally focused and implicate mechanisms by which chromatin domains harness biological processes within them. Copyright © 2015 Elsevier Inc. All rights reserved.
Hahnbeom Park
Full Text Available Protein loop modeling is a tool for predicting protein local structures of particular interest, providing opportunities for applications involving protein structure prediction and de novo protein design. Until recently, the majority of loop modeling methods have been developed and tested by reconstructing loops in frameworks of experimentally resolved structures. In many practical applications, however, the protein loops to be modeled are located in inaccurate structural environments. These include loops in model structures, low-resolution experimental structures, or experimental structures of different functional forms. Accordingly, discrepancies in the accuracy of the structural environment assumed in development of the method and that in practical applications present additional challenges to modern loop modeling methods. This study demonstrates a new strategy for employing a hybrid energy function combining physics-based and knowledge-based components to help tackle this challenge. The hybrid energy function is designed to combine the strengths of each energy component, simultaneously maintaining accurate loop structure prediction in a high-resolution framework structure and tolerating minor environmental errors in low-resolution structures. A loop modeling method based on global optimization of this new energy function is tested on loop targets situated in different levels of environmental errors, ranging from experimental structures to structures perturbed in backbone as well as side chains and template-based model structures. The new method performs comparably to force field-based approaches in loop reconstruction in crystal structures and better in loop prediction in inaccurate framework structures. This result suggests that higher-accuracy predictions would be possible for a broader range of applications. The web server for this method is available at http://galaxy.seoklab.org/loop with the PS2 option for the scoring function.
1-loop renormalization of QED{sub 2}
Casana S, Rodolfo; Dias, Sebastiao A. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)
1997-12-31
The Schwinger model, when quantized in a gauge non-invariant way exhibits a dependence on a parameter a (the Jackiw-Rajaraman parameter) in a way which is analogous to the case involving chiral fermions (the chiral Schwinger model). For all values of a {ne} 1, there are divergences in the fermionic Green`s functions. We propose a regularization of the generating functional Z({eta},{eta}-bar, J) and we use it to re normalize the theory to one loop level, in a semi-perturbative sense. At the end of the renormalization procedure we find an implicit dependence of a on the renormalization scale {mu}. (author) 9 refs.
Collider study on the loop-induced dark matter mediation
Tsai, Yuhsin, E-mail: yhtsai@umd.edu [Maryland Center for Fundamental Physics, University of Maryland, College Park, MD 20742 (United States)
2016-06-21
Collider experiments are one of the most promising ways to constrain Dark Matter (DM) interactions. For DM couplings involving light mediators, especially for the loop-mediated interactions, a meaningful interpretation of the results requires to go beyond effective field theory. In this note we discuss the study of the magnetic dipole interacting DM, focusing on a model with anarchic dark flavor structure. By including the momentum-dependent form factors that mediate the coupling – given by the Dark Penguin – in collider processes, we study bounds from monophoton, diphoton, and non-pointing photon searches at the LHC. We also compare our results to constraints from the direct detection experiments.
On a four-loop form factor in N=4
Boels, Rutger H; Yang, Gang
2016-01-01
We report on progress toward computing a four-loop supersymmetric form factor in maximally supersymmetric Yang-Mills theory. A representative example particle content from the involved supermultiplets is a stress-tensor operator with two on-shell gluons. In previous work, the integrand for this form factor was obtained using color-kinematic duality in a particularly simple form. Here the result of applying integration-by-parts identities is discussed and cross-checks of the result is performed. Rational IBP relations and their reduction are introduced as a potentially useful aide.
Integrand reduction beyond one-loop calculations
Ossola, Giovanni
2016-01-01
In this presentation, we review the general features of integrand-reduction techniques, with a particular focus on their generalization beyond one loop. We start with a brief discussion of the one-loop scenario, a case in which integrand-reduction algorithms are well established and played over the past decade an important role in the development of automated tools for the theoretical evaluation of physical observables. The generalization of integrand-reduction techniques to all loops has been the subject of several efforts in the recent past, thus providing a better understanding of the universal properties of scattering amplitudes. The ultimate goal of these studies is the development of efficient alternative computational techniques for the evaluation of Feynman integrals beyond one loop.
Analytic three-loop static potential
Lee, Roman N.; Smirnov, Alexander V.; Smirnov, Vladimir A.; Steinhauser, Matthias
2016-09-01
We present analytic results for the three-loop static potential of two heavy quarks. The analytic calculation of the missing ingredients is outlined, and results for the singlet and octet potential are provided.
Force distribution in a semiflexible loop
Waters, James T
2016-01-01
Loops undergoing thermal fluctuations are prevalent in nature. Ring-like or cross-linked polymers, cyclic macromolecules, and protein-mediated DNA loops all belong to this category. Stability of these molecules are generally described in terms of free energy, an average quantity, but it may also be impacted by local fluctuating forces acting within these systems. The full distribution of these forces can thus give us insights into mechanochemistry beyond the predictive capability of thermodynamics. In this paper, we study the force exerted by an inextensible semiflexible polymer constrained in a looped state. By using a novel simulation method termed "phase-space sampling", we generate the equilibrium distribution of chain conformations in both position and momentum space. We compute the constraint forces between the two ends of the loop in this chain ensemble using Lagrangian mechanics, and show that the mean of these forces is equal to the thermodynamic force. By analyzing kinetic and potential contribution...
Quantum Loops in Non-Local Gravity
Talaganis, Spyridon
2015-01-01
In this proceedings, I will consider quantum aspects of a non-local, infinite-derivative scalar field theory - a ${\\it toy \\, model}$ depiction of a covariant infinite-derivative, non-local extension of Einstein's general relativity which has previously been shown to be free from ghosts around the Minkowski background. The graviton propagator in this theory gets an exponential suppression making it ${\\it asymptotically \\, free}$, thus providing strong prospects of resolving various classical and quantum divergences. In particular, I will find that at $1$-loop, the $2$-point function is still divergent, but once this amplitude is renormalized by adding appropriate counter terms, the ultraviolet (UV) behavior of all other $1$-loop diagrams as well as the $2$-loop, $2$-point function remains well under control. I will go on to discuss how one may be able to generalize our computations and arguments to arbitrary loops.
Conformal anomaly of super Wilson loop
Belitsky, A V
2012-01-01
Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well-defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in ...
Introductory lectures to loop quantum gravity
Doná, Pietro
2010-01-01
We give a standard introduction to loop quantum gravity, from the ADM variables to spin network states. We include a discussion on quantum geometry on a fixed graph and its relation to a discrete approximation of general relativity.
The Universal One-Loop Effective Action
Drozd, Aleksandra; Quevillon, Jérémie; You, Tevong
2016-01-01
We present the universal one-loop effective action for all operators of dimension up to six obtained by integrating out massive, non-degenerate multiplets. Our general expression may be applied to loops of heavy fermions or bosons, and has been checked against partial results available in the literature. The broad applicability of this approach simplifies one-loop matching from an ultraviolet model to a lower-energy effective field theory (EFT), a procedure which is now reduced to the evaluation of a combination of matrices in our universal expression, without any loop integrals to evaluate. We illustrate the relationship of our results to the Standard Model (SM) EFT, using as an example the supersymmetric stop and sbottom squark Lagrangian and extracting from our universal expression the Wilson coefficients of dimension-six operators composed of SM fields.
Dimensionally continued multi-loop gauge theory
Broadhurst, D J
1999-01-01
A dimensionally continued background-field method makes the rationality of the 4-loop quenched QED beta function far more reasonable than had previously appeared. After 33 years of quest, dating from Rosner's discovery of 3-loop rationality, one finally sees cancellation of zeta values by the trace structure of individual diagrams. At 4-loops, diagram-by-diagram cancellation of $\\zeta(5)$ does not even rely on the values of integrals at d=4. Rather, it is a property of the rational functions of $d$ that multiply elements of the full d-dimensional basis. We prove a lemma: the basis consists of slices of wheels. We explain the previously mysterious suppression of $\\pi^4$ in massless gauge theory. The 4-loop QED result $\\beta_4=-46$ is obtained by setting d=4 in a precisely defined rational polynomial of d, with degree 11. The other 5 rational functions vanish at d=4.
Energy release in driven twisted coronal loops
Bareford, M R; Browning, P K; Hood, A W
2015-01-01
In the present study we investigate magnetic reconnection in twisted magnetic fluxtubes with different initial configurations. In all considered cases, energy release is triggered by the ideal kink instability, which is itself the result of applying footpoint rotation to an initially potential field. The main goal of this work is to establish the influence of the field topology and various thermodynamic effects on the energy release process. Specifically, we investigate convergence of the magnetic field at the loop footpoints, atmospheric stratification, as well as thermal conduction. In all cases, the application of vortical driving at the footpoints of an initally potential field leads to an internal kink instability. With the exception of the curved loop with high footpoint convergence, the global geometry of the loop change little during the simulation. Footpoint convergence, curvature and atmospheric structure clearly influences the rapidity with which a loop achieves instability as well as the size of t...
Loop Diuretics in the Treatment of Hypertension.
Malha, Line; Mann, Samuel J
2016-04-01
Loop diuretics are not recommended in current hypertension guidelines largely due to the lack of outcome data. Nevertheless, they have been shown to lower blood pressure and to offer potential advantages over thiazide-type diuretics. Torsemide offers advantages of longer duration of action and once daily dosing (vs. furosemide and bumetanide) and more reliable bioavailability (vs. furosemide). Studies show that the previously employed high doses of thiazide-type diuretics lower BP more than furosemide. Loop diuretics appear to have a preferable side effect profile (less hyponatremia, hypokalemia, and possibly less glucose intolerance). Studies comparing efficacy and side effect profiles of loop diuretics with the lower, currently widely prescribed, thiazide doses are needed. Research is needed to fill gaps in knowledge and common misconceptions about loop diuretic use in hypertension and to determine their rightful place in the antihypertensive arsenal.
A theory of desynchronisable closed loop system
Harsh Beohar
2010-10-01
Full Text Available The task of implementing a supervisory controller is non-trivial, even though different theories exist that allow automatic synthesis of these controllers in the form of automata. One of the reasons for this discord is due to the asynchronous interaction between a plant and its controller in implementations, whereas the existing supervisory control theories assume synchronous interaction. As a consequence the implementation suffer from the so-called inexact synchronisation problem. In this paper we address the issue of inexact synchronisation in a process algebraic setting, by solving a more general problem of refinement. We construct an asynchronous closed loop system by introducing a communication medium in a given synchronous closed loop system. Our goal is to find sufficient conditions under which a synchronous closed loop system is branching bisimilar to its corresponding asynchronous closed loop system.
A magnetohydrodynamic theory of coronal loop transients
Yeh, T.
1982-01-01
The physical and geometrical characteristics of solar coronal loop transients are described in an MHD model based on Archimedes' MHD buoyancy force. The theory was developed from interpretation of coronagraphic data, particularly from Skylab. The brightness of a loop is taken to indicate the electron density, and successive pictures reveal the electron enhancement in different columns. The forces which lift the loop off the sun surface are analyzed as an MHD buoyancy force affecting every mass element by imparting an inertial force necessary for heliocentrifugal motion. Thermal forces are responsible for transferring the ambient stress to the interior of the loop to begin the process. The kinematic and hydrostatic buoyancy overcome the gravitational force, and a flux rope can then curve upward, spiralling like a corkscrew with varying cross section around the unwinding solar magnetic field lines.
Federal Laboratory Consortium — RTC has a suite of Hardware-in-the Loop facilities that include three operational facilities that provide performance assessment and production acceptance testing of...
Off-shell two loop QCD vertices
Gracey, J A
2014-01-01
We calculate the triple gluon, ghost-gluon and quark-gluon vertex functions at two loops in the MSbar scheme in the chiral limit for an arbitrary linear covariant gauge when the external legs are all off-shell.
Modulation of DNA loop lifetimes by the free energy of loop formation
Chen, Yi-Ju; Mulligan, Peter; Spakowitz, Andrew J; Phillips, Rob
2015-01-01
Storage and retrieval of the genetic information in cells is a dynamic process that requires the DNA to undergo dramatic structural rearrangements. DNA looping is a prominent example of such a structural rearrangement that is essential for transcriptional regulation in both prokaryotes and eukaryotes, and the speed of such regulations affects the fitness of individuals. Here, we examine the in vitro looping dynamics of the classic Lac repressor gene-regulatory motif. We show that both loop association and loop dissociation at the DNA-repressor junctions depend on the elastic deformation of the DNA and protein, and that both looping and unlooping rates approximately scale with the looping J factor, which reflects the system's deformation free energy. We explain this observation by transition state theory and model the DNA-protein complex as an effective worm-like chain with twist. We introduce a finite protein-DNA binding interaction length, in competition with the characteristic DNA deformation length scale, ...
A multiple-pass ring oscillator based dual-loop phase-locked loop
Chen Danfeng; Ren Junyan; Deng Jingjing; Li Wei; Li Ning
2009-01-01
A dual-loop phase-locked loop (PLL) for wideband operation is proposed. The dual-loop architecture combines a coarse-tuning loop with a fine-tuning one, enabling a wide tuning range and low voltage-controlled oscillator (VCO) gain without poisoning phase noise and reference spur suppression performance. An analysis of the phase noise and reference spur of the dual-loop PLL is emphasized. A novel multiple-pass ring VCO is designed for the dual-loop application. It utilizes both voltage-control and current-control simultaneously in the delay cell. The PLL is fabricated in Jazz 0.18-μm RF CMOS technology. The measured tuning range is from 4.2 to 5.9 GHz. It achieves a low phase noise of-99 dBc/Hz @ 1 MHz offset from a 5.5 GHz carrier.
A multiple-pass ring oscillator based dual-loop phase-locked loop
Chen Danfeng; Ren Junyan; Deng Jingjing; Li Wei; Li Ning, E-mail: dfchen@fudan.edu.c [State Key Laboratory of ASIC and System, Fudan University, Shanghai 201203 (China)
2009-10-15
A dual-loop phase-locked loop (PLL) for wideband operation is proposed. The dual-loop architecture combines a coarse-tuning loop with a fine-tuning one, enabling a wide tuning range and low voltage-controlled oscillator (VCO) gain without poisoning phase noise and reference spur suppression performance. An analysis of the phase noise and reference spur of the dual-loop PLL is emphasized. A novel multiple-pass ring VCO is designed for the dual-loop application. It utilizes both voltage-control and current-control simultaneously in the delay cell. The PLL is fabricated in Jazz 0.18-{mu}m RF CMOS technology. The measured tuning range is from 4.2 to 5.9 GHz. It achieves a low phase noise of -99 dBc/Hz - 1 MHz offset from a 5.5 GHz carrier.
Exponential Decay of Loop Lengths in the Loop O( n) Model with Large n
Duminil-Copin, Hugo; Peled, Ron; Samotij, Wojciech; Spinka, Yinon
2017-02-01
The loop O( n) model is a model for a random collection of non-intersecting loops on the hexagonal lattice, which is believed to be in the same universality class as the spin O( n) model. It has been conjectured that both the spin and the loop O( n) models exhibit exponential decay of correlations when n > 2. We verify this for the loop O( n) model with large parameter n, showing that long loops are exponentially unlikely to occur, uniformly in the edge weight x. Our proof provides further detail on the structure of typical configurations in this regime. Putting appropriate boundary conditions, when nx 6 is sufficiently small, the model is in a dilute, disordered phase in which each vertex is unlikely to be surrounded by any loops, whereas when nx 6 is sufficiently large, the model is in a dense, ordered phase which is a small perturbation of one of the three ground states.
Closed Loop Fire Control System
1976-11-01
could involve the maintenance of a substantial aircraft velocity to counteract the prolonged exposure to a potential air defense threat. Although the...The resulting subsystem failure rate of 1329. 9 failures per 106 hours (751. 9 hours MTBF) represents a "conservative" predicition . Had detailed
Rectangular Wilson Loops at Large N
Lohmayer, Robert
2012-01-01
This work is about pure Yang Mills theory in four Euclidean dimensions with gauge group SU(N). We study rectangular smeared Wilson loops on the lattice at large N and relatively close to the large-N transition point in their eigenvalue density. We show that the string tension can be extracted from these loops but obtain a shape dependence different from the prediction of effective string theory.
Laser welding closed-loop power control
Bagger, Claus; Olsen, Flemming Ove
2003-01-01
A closed-loop control system is developed to maintain an even seam width on the root side of a laser weld by continually controlling the output laser power of a 1500 W CO2 laser.......A closed-loop control system is developed to maintain an even seam width on the root side of a laser weld by continually controlling the output laser power of a 1500 W CO2 laser....
Loop residues and catalysis in OMP synthase
Wang, Gary P.; Hansen, Michael Riis; Grubmeyer, Charles
2012-01-01
(preceding paper in this issue, DOI 10.1021/bi300083p)]. The full expression of KIEs by H105A and E107A may result from a less secure closure of the catalytic loop. The lower level of expression of the KIE by K103A suggests that in these mutant proteins the major barrier to catalysis is successful closure...... of the catalytic loop, which when closed, produces rapid and reversible catalysis....
Simple system for locating ground loops.
Bellan, P M
2007-06-01
A simple low-cost system for rapid identification of the cables causing ground loops in complex instrumentation configurations is described. The system consists of an exciter module that generates a 100 kHz ground loop current and a detector module that determines which cable conducts this test current. Both the exciter and detector are magnetically coupled to the ground circuit so there is no physical contact to the instrumentation system under test.
Deployable radiator with flexible line loop
Keeler, Bryan V. (Inventor); Lehtinen, Arthur Mathias (Inventor); McGee, Billy W. (Inventor)
2003-01-01
Radiator assembly (10) for use on a spacecraft (12) is provided including at least one radiator panel assembly (26) repeatably movable between a panel stowed position (28) and a panel deployed position (36), at least two flexible lines (40) in fluid communication with the at least one radiator panel assembly (26) and repeatably movable between a stowage loop (42) and a flattened deployed loop (44).
Zero Point Energy of Renormalized Wilson Loops
Hidaka, Yoshimasa; Pisarski, Robert D.
2009-01-01
The quark antiquark potential, and its associated zero point energy, can be extracted from lattice measurements of the Wilson loop. We discuss a unique prescription to renormalize the Wilson loop, for which the perturbative contribution to the zero point energy vanishes identically. A zero point energy can arise nonperturbatively, which we illustrate by considering effective string models. The nonperturbative contribution to the zero point energy vanishes in the Nambu model, but is nonzero wh...
Master Symmetry for Holographic Wilson Loops
Klose, Thomas; Munkler, Hagen
2016-01-01
We identify the symmetry underlying the recently observed spectral-parameter transformations of holographic Wilson loops alias minimal surfaces in AdS/CFT. The generator of this nonlocal symmetry is shown to furnish a raising operator on the classical Yangian-type charges of symmetric coset models. We explicitly demonstrate how this master symmetry acts on strong-coupling Wilson loops and indicate a possible extension to arbitrary coupling.
Laser welding closed-loop power control
Bagger, Claus; Olsen, Flemming Ove
2003-01-01
A closed-loop control system is developed to maintain an even seam width on the root side of a laser weld by continually controlling the output laser power of a 1500 W CO2 laser.......A closed-loop control system is developed to maintain an even seam width on the root side of a laser weld by continually controlling the output laser power of a 1500 W CO2 laser....
Multiple Flow Loop SCADA System Implemented on the Production Prototype Loop
Baily, Scott A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dalmas, Dale Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wheat, Robert Mitchell [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2015-11-16
The following report covers FY 15 activities to develop supervisory control and data acquisition (SCADA) system for the Northstar Moly99 production prototype gas flow loop. The goal of this effort is to expand the existing system to include a second flow loop with a larger production-sized blower. Besides testing the larger blower, this system will demonstrate the scalability of our solution to multiple flow loops.
Belitsky, A. V.
2012-11-01
We explore the duality between supersymmetric Wilson loop on null polygonal contours in maximally supersymmetric Yang-Mills theory and next-to-maximal helicity violating (NMHV) scattering amplitudes. Earlier analyses demonstrated that the use of a dimensional regulator for ultraviolet divergences, induced due to presence of the cusps on the loop, yields anomalies that break both conformal symmetry and supersymmetry. At one-loop order, these are present only in Grassmann components localized in the vicinity of a single cusp and result in a universal function for any number of sites of the polygon that can be subtracted away in a systematic manner leaving a well-defined supersymmetric remainder dual to corresponding components of the superamplitude. The question remains though whether components which were free from the aforementioned supersymmetric anomaly at leading order of perturbation theory remain so once computed at higher orders. Presently we verify this fact by calculating a particular component of the null polygonal super Wilson loop at two loops restricting the contour kinematics to a two-dimensional subspace. This allows one to perform all computations in a concise analytical form and trace the pattern of cancellations between individual Feynman graphs in a transparent fashion. As a consequence of our consideration we obtain a dual conformally invariant result for the remainder function in agreement with one-loop NMHV amplitudes.
Space Station evolution study oxygen loop closure
Wood, M. G.; Delong, D.
1993-01-01
In the current Space Station Freedom (SSF) Permanently Manned Configuration (PMC), physical scars for closing the oxygen loop by the addition of oxygen generation and carbon dioxide reduction hardware are not included. During station restructuring, the capability for oxygen loop closure was deferred to the B-modules. As such, the ability to close the oxygen loop in the U.S. Laboratory module (LAB A) and the Habitation A module (HAB A) is contingent on the presence of the B modules. To base oxygen loop closure of SSF on the funding of the B-modules may not be desirable. Therefore, this study was requested to evaluate the necessary hooks and scars in the A-modules to facilitate closure of the oxygen loop at or subsequent to PMC. The study defines the scars for oxygen loop closure with impacts to cost, weight and volume and assesses the effects of byproduct venting. In addition, the recommended scenarios for closure with regard to topology and packaging are presented.
Jonas, A; Flanagan, P R; Forstner, G G
1977-12-01
The effect of intestinal bacterial over-growth on brush border hydrolases and brush border glycoproteins was studied in nonoperated control rats, control rats with surgically introduced jejunal self-emptying blind loops, and rats with surgically introduced jejunal self-filling blind loops. Data were analyzed from blind loop segments, segments above and below the blind loops, and three corresponding segments in the nonoperated controls. Rats with self-filling blind loops had significantly greater fat excretion than controls and exhibited significantly lower conjugated:free bile salt ratios in all three segments. Maltase, sucrase, and lactase activities were significantly reduced in homogenates and isolated brush borders from the self-filling blind loop, but alkaline phosphatase was not affected. The relative degradation rate of homogenate and brush border glycoproteins was assessed by a double-isotope technique involving the injection of d-[6-(3)H]glucosamine 3 h and d-[U-(14)C]glucosamine 19 h before sacrifice, and recorded as a (3)H:(14)C ratio. The relative degradation rate in both homogenate and brush border fractions was significantly greater in most segments from rats with self-filling blind loops. In the upper and blind loop segments from rats with self-filling blind loops, the (3)H:(14)C ratios were higher in the brush border membrane than in the corresponding homogenates, indicating that the increased rates of degradation primarily involve membrane glycoproteins. Incorporation of d-[6-(3)H]glucosamine by brush border glycoproteins was not reduced in rats with self-filling blind loops, suggesting that glycoprotein synthesis was not affected. Polyacrylamide gel electrophoresis of brush border glycoproteins from the contaminated segments indicated that the large molecular weight glycoproteins, which include many of the surface hydrolases, were degraded most rapidly. Brush border maltase, isolated by immunoprecipitation, had (3)H:(14)C ratios characteristic of
Loops In Proteins (LIP)--a comprehensive loop database for homology modelling.
Michalsky, E; Goede, A; Preissner, R
2003-12-01
One of the most important and challenging tasks in protein modelling is the prediction of loops, as can be seen in the large variety of existing approaches. Loops In Proteins (LIP) is a database that includes all protein segments of a length up to 15 residues contained in the Protein Data Bank (PDB). In this study, the applicability of LIP to loop prediction in the framework of homology modelling is investigated. Searching the database for loop candidates takes less than 1 s on a desktop PC, and ranking them takes a few minutes. This is an order of magnitude faster than most existing procedures. The measure of accuracy is the root mean square deviation (RMSD) with respect to the main-chain atoms after local superposition of target loop and predicted loop. Loops of up to nine residues length were modelled with a local RMSD <1 A and those of length up to 14 residues with an accuracy better than 2 A. The results were compared in detail with a thoroughly evaluated and tested ab initio method published recently and additionally with two further methods for a small loop test set. The LIP method produced very good predictions. In particular for longer loops it outperformed other methods.
Hybrid Combustion-Gasification Chemical Looping
Herbert Andrus; Gregory Burns; John Chiu; Gregory Lijedahl; Peter Stromberg; Paul Thibeault
2009-01-07
For the past several years Alstom Power Inc. (Alstom), a leading world-wide power system manufacturer and supplier, has been in the initial stages of developing an entirely new, ultra-clean, low cost, high efficiency power plant for the global power market. This new power plant concept is based on a hybrid combustion-gasification process utilizing high temperature chemical and thermal looping technology The process consists of the oxidation, reduction, carbonation, and calcination of calcium-based compounds, which chemically react with coal, biomass, or opportunity fuels in two chemical loops and one thermal loop. The chemical and thermal looping technology can be alternatively configured as (i) a combustion-based steam power plant with CO{sub 2} capture, (ii) a hybrid combustion-gasification process producing a syngas for gas turbines or fuel cells, or (iii) an integrated hybrid combustion-gasification process producing hydrogen for gas turbines, fuel cells or other hydrogen based applications while also producing a separate stream of CO{sub 2} for use or sequestration. In its most advanced configuration, this new concept offers the promise to become the technology link from today's Rankine cycle steam power plants to tomorrow's advanced energy plants. The objective of this work is to develop and verify the high temperature chemical and thermal looping process concept at a small-scale pilot facility in order to enable AL to design, construct and demonstrate a pre-commercial, prototype version of this advanced system. In support of this objective, Alstom and DOE started a multi-year program, under this contract. Before the contract started, in a preliminary phase (Phase 0) Alstom funded and built the required small-scale pilot facility (Process Development Unit, PDU) at its Power Plant Laboratories in Windsor, Connecticut. Construction was completed in calendar year 2003. The objective for Phase I was to develop the indirect combustion loop with CO{sub 2
Krishnaswami, G S
2006-01-01
Large-N multi-matrix loop equations are formulated as quadratic difference equations in concatenation of gluon correlations. Though non-linear, they involve highest rank correlations linearly. They are underdetermined in many cases. Additional linear equations for gluon correlations, associated to symmetries of action and measure are found. Loop equations aren't differential equations as they involve left annihilation, which doesn't satisfy the Leibnitz rule with concatenation. But left annihilation is a derivation of the commutative shuffle product. Moreover shuffle and concatenation combine to define a bialgebra. Motivated by deformation quantization, we expand concatenation around shuffle in powers of q, whose physical value is 1. At zeroth order the loop equations become quadratic PDEs in the shuffle algebra. If the variation of the action is linear in iterated commutators of left annihilations, these quadratic PDEs linearize by passage to shuffle reciprocal of correlations. Remarkably, this is true for r...
Investigation of Inner Loop Flight Control Strategies for High-Speed Research
Newman, Brett; Kassem, Ayman
1999-01-01
This report describes the activities and findings conducted under contract NAS1-19858 with NASA Langley Research Center. Subject matter is the investigation of suitable flight control design methodologies and solutions for large, flexible high-speed vehicles. Specifically, methodologies are to address the inner control loops used for stabilization and augmentation of a highly coupled airframe system possibly involving rigid-body motion, structural vibrations, unsteady aerodynamics, and actuator dynamics. Techniques considered in this body of work are primarily conventional-based, and the vehicle of interest is the High-Speed Civil Transport (HSCT). Major findings include 1) current aeroelastic vehicle modeling procedures require further emphasis and refinement, 2) traditional and nontraditional inner loop flight control strategies employing a single feedback loop do not appear sufficient for highly flexible HSCT class vehicles, 3) inner loop flight control systems will, in all likelihood, require multiple interacting feedback loops, and 4) Ref. H HSCT configuration presents major challenges to designing acceptable closed-loop flight dynamics.
Kinetic Cooperativity, Loop Dynamics, and Allostery from NMR and MD simulations
Bruschweiler, Rafael
The hallmark of glucokinase (GCK), which catalyzes the phosphorylation of glucose during glycolysis, is its kinetic cooperativity whose understanding at atomic detail has remained open since its discovery over 40 years ago. I will discuss how the origin of kinetic cooperativity is rooted in intramolecular protein dynamics using NMR relaxation data of 17 isoleucines distributed over all parts of GCK. Residues of glucose-free GCK located in the small domain display a distinct exchange behavior involving multiple conformers that are substantially populated, whereas in the glucose-bound form these dynamic processes are quenched. The conformational exchange process directly competes with the enzymatic turnover at physiological glucose concentrations, thereby generating the sigmoidal rate dependence that defines kinetic cooperativity. The flexible nature of protein loops and the timescales of their dynamics are critical for many biologically important events at the molecular level, such as protein interaction and recognition processes. Based on a library of proteins, rules about loop dynamics in terms of amplitude and timescales can be derived using molecular dynamics (MD) simulations and NMR data. These rules have been implemented in the new web server ToeLoop (for Timescales Of Every Loop) that permits the prediction of loop dynamics based on an average 3D protein structure (http://spin.ccic.ohio-state.edu/index.php/loop/index).
Detection and Characterization of R Loop Structures.
Boque-Sastre, Raquel; Soler, Marta; Guil, Sonia
2017-01-01
R loops are special three stranded nucleic acid structures that comprise a nascent RNA hybridized with the DNA template strand, leaving a non-template DNA single-stranded. More specifically, R loops form in vivo as G-rich RNA transcripts invade the DNA duplex and anneal to the template strand to generate an RNA:DNA hybrid, leaving the non-template, G-rich DNA strand in a largely single-stranded conformation (Aguilera and Garcia-Muse, Mol Cell 46:115-124, 2012).DNA-RNA hybrids are a natural occurrence within eukaryotic cells, with levels of these hybrids increasing at sites with high transcriptional activity, such as during transcription initiation, repression, and elongation. RNA-DNA hybrids influence genomic instability, and growing evidence points to an important role for R loops in active gene expression regulation (Ginno et al., Mol Cell 45, 814-825, 2012; Sun et al., Science 340: 619-621, 2013; Bhatia et al., Nature 511, 362-365, 2014). Analysis of the occurrence of such structures is therefore of increasing relevance and herein we describe methods for the in vivo and in vitro identification and characterization of R loops in mammalian systems.R loops (DNA:RNA hybrids and the associated single-stranded DNA) have been traditionally associated with threats to genome integrity, making some regions of the genome more prone to DNA-damaging and mutagenic agents. Initially considered to be rare byproducts of transcription, over the last decade accumulating evidence has pointed to a new view in which R loops form more frequently than previously thought. The R loop field has become an increasingly expanded area of research, placing these structures as a major threat to genome stability but also as potential regulators of gene expression. Special interest has arisen as they have also been linked to a variety of diseases, including neurological disorders and cancer, positioning them as potential therapeutic targets [5].
Integration of calcium and chemical looping combustion using composite CaO/CuO-based materials.
Manovic, Vasilije; Anthony, Edward J
2011-12-15
Calcium looping cycles (CaL) and chemical looping combustion (CLC) are two new, developing technologies for reduction of CO(2) emissions from plants using fossil fuels for energy production, which are being intensively examined. Calcium looping is a two-stage process, which includes oxy-fuel combustion for sorbent regeneration, i.e., generation of a concentrated CO(2) stream. This paper discuss the development of composite materials which can use copper(II)-oxide (CuO) as an oxygen carrier to provide oxygen for the sorbent regeneration stage of calcium looping. In other words, the work presented here involves integration of calcium looping and chemical looping into a new class of postcombustion CO(2) capture processes designated as integrated CaL and CLC (CaL-CLC or Ca-Cu looping cycles) using composite pellets containing lime (CaO) and CuO together with the addition of calcium aluminate cement as a binder. Their activity was tested in a thermogravimetric analyzer (TGA) during calcination/reduction/oxidation/carbonation cycles. The calcination/reduction typically was performed in methane (CH(4)), and the oxidation/carbonation stage was carried out using a gas mixture containing both CO(2) and O(2). It was confirmed that the material synthesized is suitable for the proposed cycles; with the very favorable finding that reduction/oxidation of the oxygen carrier is complete. Various schemes for the Ca-Cu looping process have been explored here that would be compatible with these new composite materials, along with some different possibilities for flow directions among carbonator, calciner, and air reactor.
Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.
Marinello, Jessica; Bertoncini, Stefania; Aloisi, Iris; Cristini, Agnese; Malagoli Tagliazucchi, Guidantonio; Forcato, Mattia; Sordet, Olivier; Capranico, Giovanni
2016-01-01
Topoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at divergent CpG-island promoters and, transiently, DNA/RNA hybrids (R-loop) in nuclear and mitochondrial genomes of colon cancer HCT116 cells. However, the relationship between R-loops and aRNAs was not established. Here, we show that aRNAs can form R-loops in N-TERA-2 cells under physiological conditions, and that promoter-associated R-loops are somewhat increased and extended in length immediately upon cell exposure to CPT. In contrast, persistent Top1ccs reduce the majority of R-loops suggesting that CPT-accumulated aRNAs are not commonly involved in R-loops. The enhancement of aRNAs by Top1ccs is present both in human colon cancer HCT116 cells and WI38 fibroblasts suggesting a common response of cancer and normal cells. Although Top1ccs lead to DSB and DDR kinases activation, we do not detect a dependence of aRNA accumulation on ATM or DNA-PK activation. However, we showed that the cell response to persistent Top1ccs can involve an impairment of aRNA turnover rather than a higher synthesis rate. Finally, a genome-wide analysis shows that persistent Top1ccs also determine an accumulation of sense transcripts at 5'-end gene regions suggesting an increased occurrence of truncated transcripts. Taken together, the results indicate that Top1 may regulate transcription initiation by modulating RNA polymerase-generated negative supercoils, which can in turn favor R-loop formation at promoters, and that transcript accumulation at TSS is a response to persistent transcriptional stress by Top1 poisoning.
Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.
Jessica Marinello
Full Text Available Topoisomerase I-DNA-cleavage complexes (Top1cc stabilized by camptothecin (CPT have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs levels at divergent CpG-island promoters and, transiently, DNA/RNA hybrids (R-loop in nuclear and mitochondrial genomes of colon cancer HCT116 cells. However, the relationship between R-loops and aRNAs was not established. Here, we show that aRNAs can form R-loops in N-TERA-2 cells under physiological conditions, and that promoter-associated R-loops are somewhat increased and extended in length immediately upon cell exposure to CPT. In contrast, persistent Top1ccs reduce the majority of R-loops suggesting that CPT-accumulated aRNAs are not commonly involved in R-loops. The enhancement of aRNAs by Top1ccs is present both in human colon cancer HCT116 cells and WI38 fibroblasts suggesting a common response of cancer and normal cells. Although Top1ccs lead to DSB and DDR kinases activation, we do not detect a dependence of aRNA accumulation on ATM or DNA-PK activation. However, we showed that the cell response to persistent Top1ccs can involve an impairment of aRNA turnover rather than a higher synthesis rate. Finally, a genome-wide analysis shows that persistent Top1ccs also determine an accumulation of sense transcripts at 5'-end gene regions suggesting an increased occurrence of truncated transcripts. Taken together, the results indicate that Top1 may regulate transcription initiation by modulating RNA polymerase-generated negative supercoils, which can in turn favor R-loop formation at promoters, and that transcript accumulation at TSS is a response to persistent transcriptional stress by Top1 poisoning.
Open-loop versus closed-loop control of MEMS devices: choices and issues
Borovic, B.; Liu, A. Q.; Popa, D.; Cai, H.; Lewis, F. L.
2005-10-01
From a controls point of view, micro electromechanical systems (MEMS) can be driven in an open-loop and closed-loop fashion. Commonly, these devices are driven open-loop by applying simple input signals. If these input signals become more complex by being derived from the system dynamics, we call such control techniques pre-shaped open-loop driving. The ultimate step for improving precision and speed of response is the introduction of feedback, e.g. closed-loop control. Unlike macro mechanical systems, where the implementation of the feedback is relatively simple, in the MEMS case the feedback design is quite problematic, due to the limited availability of sensor data, the presence of sensor dynamics and noise, and the typically fast actuator dynamics. Furthermore, a performance comparison between open-loop and closed-loop control strategies has not been properly explored for MEMS devices. The purpose of this paper is to present experimental results obtained using both open- and closed-loop strategies and to address the comparative issues of driving and control for MEMS devices. An optical MEMS switching device is used for this study. Based on these experimental results, as well as computer simulations, we point out advantages and disadvantages of the different control strategies, address the problems that distinguish MEMS driving systems from their macro counterparts, and discuss criteria to choose a suitable control driving strategy.
Attacking One-loop Multi-leg Feynman Integrals with the Loop-Tree Duality
Chachamis, Grigorios; Draggiotis, Petros; Rodrigo, German
2016-01-01
We discuss briefly the first numerical implementation of the Loop-Tree Duality (LTD) method. We apply the LTD method in order to calculate ultraviolet and infrared finite multi-leg one-loop Feynman integrals. We attack scalar and tensor integrals with up to six legs (hexagons). The LTD method shows an excellent performance independently of the number of external legs.
Cetin, Ibrahim
2015-01-01
The purpose of this study is to explore students' understanding of loops and nested loops concepts. Sixty-three mechanical engineering students attending an introductory programming course participated in the study. APOS (Action, Process, Object, Schema) is a constructivist theory developed originally for mathematics education. This study is the…
Meggiolaro, E
2005-01-01
We shall discuss about the infrared finitness and some analyticity properties of the loop-loop scattering amplitudes in gauge theories, when going from Minkowskian to Euclidean theory, and we shall see how they can be related to the still unsolved problem of the s-dependence of the hadron-hadron total cross-sections.
Parallelization of While Loops in Nested Loop Programs for Shared-Memory Multiprocessor Systems
Geuns, Stefan J.; Bekooij, Marco J.G.; Bijlsma, Tjerk; Corporaal, Henk
2011-01-01
Many applications contain loops with an undetermined number of iterations. These loops have to be parallelized in order to increase the throughput when executed on an embedded multiprocessor platform. This paper presents a method to automatically extract a parallel task graph based on function level
Liu, Ning; Peterson, Craig L; Hayes, Jeffrey J
2011-10-01
The multisubunit SWI/SNF and RSC complexes utilize energy derived from ATP hydrolysis to mobilize nucleosomes and render the DNA accessible for various nuclear processes. Here we test the idea that remodeling involves intermediates with mobile DNA bulges or loops within the nucleosome by cross-linking the H2A N- or C-terminal tails together to generate protein "loops" that constrict separation of the DNA from the histone surface. Analyses indicate that this intranucleosomal cross-linking causes little or no change in remodeling-dependent exposure of DNA sequences within the nucleosome to restriction enzymes. However, cross-linking inhibits nucleosome mobilization and blocks complete movement of nucleosomes to extreme end positions on the DNA fragments. These results are consistent with evidence that nucleosome remodeling involves intermediates with DNA loops on the nucleosome surface but indicate that such loops do not freely diffuse about the surface of the histone octamer. We propose a threading model for movement of DNA loops around the perimeter of the nucleosome core.
Unusual loop-sequence flexibility of the proximal RNA replication element in EMCV.
Jan Zoll
Full Text Available Picornaviruses contain stable RNA structures at the 5' and 3' ends of the RNA genome, OriL and OriR involved in viral RNA replication. The OriL RNA element found at the 5' end of the enterovirus genome folds into a cloverleaf-like configuration. In vivo SELEX experiments revealed that functioning of the poliovirus cloverleaf depends on a specific structure in this RNA element. Little is known about the OriL of cardioviruses. Here, we investigated structural aspects and requirements of the apical loop of proximal stem-loop SL-A of mengovirus, a strain of EMCV. Using NMR spectroscopy, we showed that the mengovirus SL-A apical loop consists of an octaloop. In vivo SELEX experiments demonstrated that a large number of random sequences are tolerated in the apical octaloop that support virus replication. Mutants in which the SL-A loop size and the length of the upper part of the stem were varied showed that both stem-length and stability of the octaloop are important determinants for viral RNA replication and virus reproduction. Together, these data show that stem-loop A plays an important role in virus replication. The high degree of sequence flexibility and the lack of selective pressure on the octaloop argue against a role in sequence specific RNA-protein or RNA-RNA interactions in which octaloop nucleotides are involved.
Black hole entropy with and without log correction in loop quantum gravity
Mitra, P
2014-01-01
Earlier calculations of black hole entropy in loop quantum gravity have given a term proportional to the area with a correction involving the logarithm of the area when the area eigenvalue is close to the classical area. However the calculations yield an entropy proportional to the area eigenvalue with no such correction when the area eigenvalue is large compared to the classical area.
Chromatin looping and epigenetic regulation at the maize b1 locus
Louwers, M.L.D.
2008-01-01
In this thesis, the effect of epigenetic regulation on long-range chromatin looping is studied. As a model system we used two maize b1 epialleles involved in paramutation. Paramutation entails a trans-interaction between two alleles whereby one allele heritably changes the expression level of the ot
Bootstrapping the Three-Loop Hexagon
Dixon, Lance J.; /CERN /SLAC; Drummond, James M.; /CERN /Annecy, LAPTH; Henn, Johannes M.; /Humboldt U., Berlin /Santa Barbara, KITP
2011-11-08
We consider the hexagonal Wilson loop dual to the six-point MHV amplitude in planar N = 4 super Yang-Mills theory. We apply constraints from the operator product expansion in the near-collinear limit to the symbol of the remainder function at three loops. Using these constraints, and assuming a natural ansatz for the symbol's entries, we determine the symbol up to just two undetermined constants. In the multi-Regge limit, both constants drop out from the symbol, enabling us to make a non-trivial confirmation of the BFKL prediction for the leading-log approximation. This result provides a strong consistency check of both our ansatz for the symbol and the duality between Wilson loops and MHV amplitudes. Furthermore, we predict the form of the full three-loop remainder function in the multi-Regge limit, beyond the leading-log approximation, up to a few constants representing terms not detected by the symbol. Our results confirm an all-loop prediction for the real part of the remainder function in multi-Regge 3 {yields} 3 scattering. In the multi-Regge limit, our result for the remainder function can be expressed entirely in terms of classical polylogarithms. For generic six-point kinematics other functions are required.
Logical inference techniques for loop parallelization
Oancea, Cosmin E.
2012-01-01
This paper presents a fully automatic approach to loop parallelization that integrates the use of static and run-time analysis and thus overcomes many known difficulties such as nonlinear and indirect array indexing and complex control flow. Our hybrid analysis framework validates the parallelization transformation by verifying the independence of the loop\\'s memory references. To this end it represents array references using the USR (uniform set representation) language and expresses the independence condition as an equation, S = Ø, where S is a set expression representing array indexes. Using a language instead of an array-abstraction representation for S results in a smaller number of conservative approximations but exhibits a potentially-high runtime cost. To alleviate this cost we introduce a language translation F from the USR set-expression language to an equally rich language of predicates (F(S) ⇒ S = Ø). Loop parallelization is then validated using a novel logic inference algorithm that factorizes the obtained complex predicates (F(S)) into a sequence of sufficient-independence conditions that are evaluated first statically and, when needed, dynamically, in increasing order of their estimated complexities. We evaluate our automated solution on 26 benchmarks from PERFECTCLUB and SPEC suites and show that our approach is effective in parallelizing large, complex loops and obtains much better full program speedups than the Intel and IBM Fortran compilers. Copyright © 2012 ACM.
Radio Pulsating Structures with Coronal Loop Contraction
Kallunki, J.; Pohjolainen, S.
2012-10-01
We present a multi-wavelength study of a solar eruption event on 20 July 2004, comprising observations in Hα, EUV, soft X-rays, and in radio waves with a wide frequency range. The analyzed data show both oscillatory patterns and shock wave signatures during the impulsive phase of the flare. At the same time, large-scale EUV loops located above the active region were observed to contract. Quasi-periodic pulsations with ˜ 10 and ˜ 15 s oscillation periods were detected both in microwave - millimeter waves and in decimeter - meter waves. Our calculations show that MHD oscillations in the large EUV loops - but not likely in the largest contracting loops - could have produced the observed periodicity in radio emission, by triggering periodic magnetic reconnection and accelerating particles. As the plasma emission in decimeter - meter waves traces the accelerated particle beams and the microwave emission shows a typical gyrosynchrotron flux spectrum (emission created by trapped electrons within the flare loop), we find that the particles responsible for the two different types of emission could have been accelerated in the same process. Radio imaging of the pulsed decimetric - metric emission and the shock-generated radio type II burst in the same wavelength range suggest a rather complex scenario for the emission processes and locations. The observed locations cannot be explained by the standard model of flare loops with an erupting plasmoid located above them, driving a shock wave at the CME front.
Miniature loops in the solar corona
Barczynski, Krzysztof; Savage, Sabrina L
2016-01-01
Magnetic loops filled with hot plasma are the main building blocks of the solar corona. Usually they have lengths of the order of the barometric scale height in the corona that is 50 Mm. Previously it has been suggested that miniature versions of hot loops exist. These would have lengths of only 1 Mm barely protruding from the chromosphere and spanning across just one granule in the photosphere. Such short loops are well established at transition region temperatures (0.1 MK), and we investigate if such miniature loops also exist at coronal temperatures (>1 MK). We used extreme UV imaging (EUV) observations from the High-resolution Coronal Imager (Hi-C) at an unprecedented spatial resolution of 0.3" to 0.4". Together with EUV imaging and magnetogram data from the Solar Dynamics Observatory (SDO) and X-Ray Telescope (XRT) data from Hinode we investigated the spatial, temporal and thermal evolution of small loop-like structures in the solar corona above a plage region close to an active region and compared this ...
Numerical simulation of a natural circulation loop
Verissimo, Gabriel L.; Moreira, Maria de Lourdes; Faccini, Jose Luiz H., E-mail: gabrielverissimo@poli.ufrj.b, E-mail: malu@ien.gov.b, E-mail: faccini@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)
2011-07-01
This work presents a numerical simulation of a natural circulation loop using computational fluid dynamics. The simulated loop is an experimental model in a reduced scale of 1:10 of a passive heat removal system typical of advanced PWR reactors. The loop is composed of a heating vessel containing 52 electric heaters, a vertical shell-tube heat exchanger and a column of expansion. The working fluid is distilled water. Initially it was created a tridimensional geometric model of the loop components. After that, it was generated a tridimensional mesh of finite elements in order to calculate the variables of the problem. The boundaries of the numerical simulation were the power of the electric resistances and the cooling flow in the secondary side of the heat exchanger. The initial conditions were the temperature, the pressure and the fluid velocity at the time just before the power has been switched on. The results of this simulation were compared with the experimental data, in terms of the evolution of the temperatures in different locations of the loop, and of the average natural circulation flow as a function of time for a given power. (author)
Empirical potential simulations of interstitial dislocation loops in uranium dioxide
Le Prioux, Arno; Fossati, Paul; Maillard, Serge; Jourdan, Thomas; Maugis, Philippe
2016-10-01
Stoichiometric circular shaped interstitial dislocation loop energies are calculated in stoichiometric UO2 by empirical potential simulation. The Burgers vector directions studied are and . The main structural properties of each type of interstitial dislocation loop are determined, including stacking fault energy. Defect energies are compared and a maximum size for stable dislocation loops before transition to dislocation loops is given. A model of dislocation loop energy based on elasticity theory is then fitted on the basis of these simulation results.
Utilization of chemical looping strategy in coal gasification processes
Liangshih Fan; Fanxing Li; Shwetha Ramkumar
2008-01-01
Three chemical looping gasification processes, i. e. Syngas Chemical Looping (SCL) process, Coal Direct Chemical Looping (CDCL) process, and Calcium Looping process (CLP), are being developed at the Ohio State University (OSU). These processes utilize simple reaction schemes to convert carbonaceous fuels into products such as hydrogen, electricity, and synthetic fuels through the transformation of a highly reactive, highly recyclable chemical intermediate. In this paper, these novel chemical looping gasification processes are described and their advantages and potential challenges for commercialization are discussed.
BPS Wilson loops and Bremsstrahlung function in ABJ(M): a two loop analysis
Bianchi, Marco S. [Institut für Physik, Humboldt-Universität zu Berlin,Newtonstraße 15, 12489 Berlin (Germany); Griguolo, Luca [Dipartimento di Fisica e Scienze della Terra, Università di Parmaand INFN Gruppo Collegato di Parma,Viale G.P. Usberti 7/A, 43100 Parma (Italy); Leoni, Matias [Physics Department, FCEyN-UBA & IFIBA-CONICETCiudad Universitaria, Pabellón I, 1428, Buenos Aires (Argentina); Penati, Silvia [Dipartimento di Fisica, Università di Milano-Bicoccaand INFN, Sezione di Milano-Bicocca,Piazza della Scienza 3, I-20126 Milano (Italy); Seminara, Domenico [Dipartimento di Fisica, Università di Firenzeand INFN Sezione di Firenze,via G. Sansone 1, 50019 Sesto Fiorentino (Italy)
2014-06-19
We study a family of circular BPS Wilson loops in N=6 super Chern-Simons-matter theories, generalizing the usual 1/2-BPS circle. The scalar and fermionic couplings depend on two deformation parameters and these operators can be considered as the ABJ(M) counterpart of the DGRT latitudes defined in N=4 SYM. We perform a complete two-loop analysis of their vacuum expectation value, discuss the appearance of framing-like phases and propose a general relation with cohomologically equivalent bosonic operators. We make an all-loop proposal for computing the Bremsstrahlung function associated to the 1/2-BPS cusp in terms of these generalized Wilson loops. When applied to our two-loop result it reproduces the known expression. Finally, we comment on the generalization of this proposal to the bosonic 1/6-BPS case.
Pismensky, Artem L
2015-01-01
The method of calculation of $\\varepsilon$-expansion in model of scalar field with $\\varphi^3$-interaction based on conformal bootstrap equations is proposed. This technique is based on self-consistent skeleton equations involving full propagator and full triple vertex. Analytical computations of the Fisher's index $\\eta$ are performed in four-loop approximation. The three-loop result coincides with one obtained previously by the renormalization group equations technique based on calculation of a larger number of Feynman diagrams. The four-loop result agrees with its numerical value obtained by other authors.
Looping through the Lamb Shift
Hazi, A U
2007-02-06
Sometimes in science, a small measurement can have big ramifications. For a team of Livermore scientists, such was the case when they measured a small shift in the spectrum of extremely ionized atoms of uranium. The measurement involves the Lamb shift, a subtle change in the energy of an electron orbiting an atom's nucleus. The precision of the Livermore result was 10 times greater than that of existing measurements, making it the best measurement to date of a complicated correction to the simplest quantum description of how atoms behave. The measurement introduces a new realm in the search for deviations between the theory of quantum electrodynamics (QED), which is an extension of quantum mechanics, and the real world. Such deviations, if discovered, would have far-reaching consequences, indicating that QED is not a fundamental theory of nature.
An Holomorphic Study Of Smarandache Automorphic and Cross Inverse Property Loops
Jaiyeola, Temitope Gbolahan
2008-01-01
By studying the holomorphic structure of automorphic inverse property quasigroups and loops[AIPQ and (AIPL)] and cross inverse property quasigroups and loops[CIPQ and (CIPL)], it is established that the holomorph of a loop is a Smarandache; AIPL, CIPL, K-loop, Bruck-loop or Kikkawa-loop if and only if its Smarandache automorphism group is trivial and the loop is itself is a Smarandache; AIPL, CIPL, K-loop, Bruck-loop or Kikkawa-loop.
Automatic Loop Parallelization via Compiler Guided Refactoring
Larsen, Per; Ladelsky, Razya; Lidman, Jacob
For many parallel applications, performance relies not on instruction-level parallelism, but on loop-level parallelism. Unfortunately, many modern applications are written in ways that obstruct automatic loop parallelization. Since we cannot identify sufficient parallelization opportunities...... for these codes in a static, off-line compiler, we developed an interactive compilation feedback system that guides the programmer in iteratively modifying application source, thereby improving the compiler’s ability to generate loop-parallel code. We use this compilation system to modify two sequential...... benchmarks, finding that the code parallelized in this way runs up to 8.3 times faster on an octo-core Intel Xeon 5570 system and up to 12.5 times faster on a quad-core IBM POWER6 system. Benchmark performance varies significantly between the systems. This suggests that semi-automatic parallelization should...
Parallelizing More Loops with Compiler Guided Refactoring
Larsen, Per; Ladelsky, Razya; Lidman, Jacob
2012-01-01
The performance of many parallel applications relies not on instruction-level parallelism but on loop-level parallelism. Unfortunately, automatic parallelization of loops is a fragile process; many different obstacles affect or prevent it in practice. To address this predicament we developed...... an interactive compilation feedback system that guides programmers in iteratively modifying their application source code. This helps leverage the compiler’s ability to generate loop-parallel code. We employ our system to modify two sequential benchmarks dealing with image processing and edge detection......, resulting in scalable parallelized code that runs up to 8.3 times faster on an eightcore Intel Xeon 5570 system and up to 12.5 times faster on a quad-core IBM POWER6 system. Benchmark performance varies significantly between the systems. This suggests that semi-automatic parallelization should be combined...
Logical inference techniques for loop parallelization
Oancea, Cosmin Eugen; Rauchwerger, Lawrence
2012-01-01
This paper presents a fully automatic approach to loop parallelization that integrates the use of static and run-time analysis and thus overcomes many known difficulties such as nonlinear and indirect array indexing and complex control flow. Our hybrid analysis framework validates...... the parallelization transformation by verifying the independence of the loop's memory references. To this end it represents array references using the USR (uniform set representation) language and expresses the independence condition as an equation, S={}, where S is a set expression representing array indexes. Using...... ( F(S) => S = {} ). Loop parallelization is then validated using a novel logic inference algorithm that factorizes the obtained complex predicates F(S) into a sequence of sufficient-independence conditions that are evaluated first statically and, when needed, dynamically, in increasing order...
Hybrid Models in Loop Quantum Cosmology
Navascués, B Elizaga; Marugán, G A Mena
2016-01-01
In the framework of Loop Quantum Cosmology, inhomogeneous models are usually quantized by means of a hybrid approach that combines loop quantization techniques with standard quantum field theory methods. This approach is based on a splitting of the phase space in a homogeneous sector, formed by global, zero-modes, and an inhomogeneous sector, formed by the remaining, infinite number of modes, that describe the local degrees of freedom. Then, the hybrid quantization is attained by adopting a loop representation for the homogeneous gravitational sector, while a Fock representation is used for the inhomogeneities. The zero-mode of the Hamiltonian constraint operator couples the homogeneous and inhomogeneous sectors. The hybrid approach, therefore, is expected to provide a suitable quantum theory in regimes where the main quantum effects of the geometry are those affecting the zero-modes, while the inhomogeneities, still being quantum, can be treated in a more conventional way. This hybrid strategy was first prop...
Are loop quantum cosmos never singular?
Singh, Parampreet
2009-01-01
A unified treatment of all known types of singularities for flat, isotropic and homogeneous spacetimes in the framework of loop quantum cosmology (LQC) is presented. These include bangs, crunches and all future singularities. Using effective spacetime description we perform a model independent general analysis of the properties of curvature, behavior of geodesics and strength of singularities. For illustration purposes a phenomenological model based analysis is also performed. We show that all values of the scale factor at which a strong singularity may occur are excluded from the effective loop quantum spacetime. Further, if the evolution leads to either a vanishing or divergent scale factor then the loop quantum universe is asymptotically deSitter in that regime. We also show that there exist a class of sudden extremal events, which includes a recently discussed possibility, for which the curvature or its derivatives will always diverge. Such events however turn out to be harmless weak curvature singulariti...
Afriat, Alexander
2013-01-01
In discussions of the Aharonov-Bohm effect, Healey and Lyre have attributed reality to loops $\\sigma_0$ (or hoops $[\\sigma_0]$), since the electromagnetic potential $A$ is unmeasurable and can therefore be transformed. I argue that $[A]=[A+d\\lambda]_{\\lambda}$ and the hoop $[\\sigma_0]$ are related by a meaningful duality, so that however one feels about $[A]$ (or any potential $A\\in[A]$), it is no worse than $[\\sigma_0]$ (or any loop $\\sigma_0\\in[\\sigma_0]$): no ontological firmness is gained by retreating to the loops, which are just as flimsy as the potentials. And one wonders how the unmeasurability of one entity can invest another with physical reality; would an eventual observation of $A$ dissolve $\\sigma_0$, consigning it to a realm of incorporeal mathematical abstractions?
Closed-loop approach to thermodynamics
Goupil, C; Herbert, E; Benenti, G; D'Angelo, Y; Lecoeur, Ph
2016-01-01
We present the closed-loop approach to linear nonequilibrium thermodynamics considering a generic heat engine dissipatively connected to two temperature baths. The system is usually quite generally characterized by two parameters: the output power $P$ and the conversion efficiency $\\eta$, to which we add a third one, the working frequency $\\omega$. We establish that a detailed understanding of the effects of the dissipative coupling on the energy conversion process, necessitates the knowledge of only two quantities: the system's feedback factor $\\beta$ and its open-loop gain $A_{0}$, the product of which, $A_{0}\\beta$, characterizes the interplay between the efficiency, the output power and the operating rate of the system. The feedback loop approach thus provides a versatile and economical, hence efficient, tool for the study of any conversion engine operation for which a feedback factor may be defined as illustrated with a thermoelectric system.
Marijan Jurgo
2013-05-01
Full Text Available The paper reviews working principles of phase-locked loop and drawbacks of classical PLL structure in nanometric technologies. It is proposed to replace the classical structure by all-digital phase-locked loop structure. Authors described the main blocks of all-digital phase-locked loop (time to digital converter and digitally controlled oscillator and overviewed the quantization noise arising in these blocks as well as its minimization strategies. The calculated inverter delay in 65 nm CMOS technology was from 8.64 to 27.71 ps and time to digital converter quantization noise was from −104.33 to −82.17 dBc/Hz, with tres = 8.64–27.71 ps, TSVG = 143–333 ps, FREF = 20–60 MHz.Article in Lithuanian
A Cosmological Sector in Loop Quantum Gravity
Koslowski, Tim A
2007-01-01
We use the method of embedding a subsystem (i.e. its observable algebra) into a larger quantum system to extract a cosmological sector from full Loop Quantum Gravity. The application of this method provides a setting for a systematic study of the interplay between diffeomorphism invariance and symmetry reduction. The non-triviality of this relation is shown by extracting a cosmological system that has configurations variables that are very similar to the ones of a super-selection sector of standard Loop Quantum Cosmology. The full operator algebra however turns out to be different from standard Loop Quantum Cosmology. The homogeneous isotropic sector of pure gravity turns out to be quantum mechanics on a circle. The dynamics of our system seems pathological at first sight, and we give both mathematical and physical reasons for this behavior and we explain a strategy to cure these pathologies.
Closed-loop approach to thermodynamics
Goupil, C.; Ouerdane, H.; Herbert, E.; Benenti, G.; D'Angelo, Y.; Lecoeur, Ph.
2016-09-01
We present the closed-loop approach to linear nonequilibrium thermodynamics considering a generic heat engine dissipatively connected to two temperature baths. The system is usually quite generally characterized by two parameters: the output power P and the conversion efficiency η , to which we add a third one, the working frequency ω . We establish that a detailed understanding of the effects of the dissipative coupling on the energy conversion process requires only knowing two quantities: the system's feedback factor β and its open-loop gain A0, which product A0β characterizes the interplay between the efficiency, the output power, and the operating rate of the system. By raising the abstract hermodynamic analysis to a higher level, the feedback loop approach provides a versatile and economical, hence fairly efficient, tool for the study of any conversion engine operation for which a feedback factor can be defined.
Belitsky, A V
2012-01-01
We explore the duality between supersymmetric Wilson loop on null polygonal contours in maximally supersymmetric Yang-Mills theory and next-to-maximal helicity violating (NMHV) scattering amplitudes. Earlier analyses demonstrated that the use of a dimensional regulator for ultraviolet divergences, induced due to presence of the cusps on the loop, yields anomalies that break both conformal symmetry and supersymmetry. At one-loop order, these are present only in Grassmann components localized in the vicinity of a single cusp and result in a universal function for any number of sites of the polygon that can be subtracted away in a systematic manner leaving a well-defined supersymmetric remainder dual to corresponding components of the superamplitude. The question remains though whether components which were free from the aforementioned supersymmetric anomaly at leading order of perturbation theory remain so once computed at higher orders. Presently we verify this fact by calculating a particular component of the...
Automated one-loop calculations with GOSAM
Cullen, Gavin [Edinburgh Univ. (United Kingdom). School of Physics and Astronomy; Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Greiner, Nicolas [Illinois Univ., Urbana-Champaign, IL (United States). Dept. of Physics; Max-Planck-Institut fuer Physik, Muenchen (Germany); Heinrich, Gudrun; Reiter, Thomas [Max-Planck-Institut fuer Physik, Muenchen (Germany); Luisoni, Gionata [Durham Univ. (United Kingdom). Inst. for Particle Physics Phenomenology; Mastrolia, Pierpaolo [Max-Planck-Institut fuer Physik, Muenchen (Germany); Padua Univ. (Italy). Dipt. di Fisica; Ossola, Giovanni [New York City Univ., NY (United States). New York City College of Technology; New York City Univ., NY (United States). The Graduate School and University Center; Tramontano, Francesco [European Organization for Nuclear Research (CERN), Geneva (Switzerland)
2011-11-15
We present the program package GoSam which is designed for the automated calculation of one-loop amplitudes for multi-particle processes in renormalisable quantum field theories. The amplitudes, which are generated in terms of Feynman diagrams, can be reduced using either D-dimensional integrand-level decomposition or tensor reduction. GoSam can be used to calculate one-loop QCD and/or electroweak corrections to Standard Model processes and offers the flexibility to link model files for theories Beyond the Standard Model. A standard interface to programs calculating real radiation is also implemented. We demonstrate the flexibility of the program by presenting examples of processes with up to six external legs attached to the loop. (orig.)
Transition probability spaces in loop quantum gravity
Guo, Xiao-Kan
2016-01-01
We study the (generalized) transition probability spaces, in the sense of Mielnik and Cantoni, for spacetime quantum states in loop quantum gravity. First, we show that loop quantum gravity admits the structures of transition probability spaces. This is achieved by first checking such structures in covariant quantum mechanics, and then passing to spin foam models via the general boundary formulation. The transition probability space thus defined gives a simple way to reconstruct the Hilbert space of the canonical theory and the relevant quantum logical structure. Second, we show that the transition probability space and in particular the spin foam model are 2-categories. Then we discuss how to realize property transitions and causality in this categorical context in connection with presheaves on quantaloids and respectively causal categories. We conclude that transition probability spaces provide us with an alternative framework to understand various foundational questions of loop quantum gravity.
Nonmedian Direct Products of Graphs with Loops
Krop, Elliot
2011-01-01
A \\emph{median graph} is a connected graph in which, for every three vertices, there exists a unique vertex $m$ lying on the geodesic between any two of the given vertices. We show that the only median graphs of the direct product $G\\times H$ are formed when $G=P_k$, for any integer $k\\geq 3$ and $H=P_l$, for any integer $l\\geq 2$, with a loop at an end vertex, where the direct product is taken over all connected graphs $G$ on at least three vertices or at least two vertices with at least one loop, and connected graphs $H$ with at least one loop.
Illusory spirals and loops in crystal growth.
Shtukenberg, Alexander G; Zhu, Zina; An, Zhihua; Bhandari, Misha; Song, Pengcheng; Kahr, Bart; Ward, Michael D
2013-10-22
The theory of dislocation-controlled crystal growth identifies a continuous spiral step with an emergent lattice displacement on a crystal surface; a mechanistic corollary is that closely spaced, oppositely winding spirals merge to form concentric loops. In situ atomic force microscopy of step propagation on pathological L-cystine crystals did indeed show spirals and islands with step heights of one lattice displacement. We show by analysis of the rates of growth of smaller steps only one molecule high that the major morphological spirals and loops are actually consequences of the bunching of the smaller steps. The morphology of the bunched steps actually inverts the predictions of the theory: Spirals arise from pairs of dislocations, loops from single dislocations. Only through numerical simulation of the growth is it revealed how normal growth of anisotropic layers of molecules within the highly symmetrical crystals can conspire to create features in apparent violation of the classic theory.
The blind loop syndrome in children.
Stewart, B A; Karrer, F M; Hall, R J; Lilly, J R
1990-08-01
Anatomical abnormalities of the small bowel that cause intestinal stagnation result in bacterial overgrowth and a blind loop syndrome (BLS). Bacterial breakdown of bile salts and deamination of protein lead to malabsorption, steatorrhea, and fat-soluble vitamin deficiencies. Four children developed BLS as a complication of necrotizing enterocolitis, jejunal atresia, gastroschisis, and biliary atresia. BLS was suggested by abdominal pain, feculent vomiting, steatorrhea, and hypoalbuminemia. Dilated, stagnant bowel loops were demonstrated in each instance by upper gastrointestinal contrast study. Positive intestinal bacterial aspirates were confirmatory. Antibiotic treatment in two patients improved symptomatology but all children ultimately required surgery. Surgical procedures consisted of blind loop resection, intestinal plication, and catheterization of the bilioenteric conduit. All patients are now asymptomatic but one child suffers from parenteral nutrition-related cirrhosis and another requires chronic antibiotic therapy.
Quantum Monte Carlo with directed loops.
Syljuåsen, Olav F; Sandvik, Anders W
2002-10-01
We introduce the concept of directed loops in stochastic series expansion and path-integral quantum Monte Carlo methods. Using the detailed balance rules for directed loops, we show that it is possible to smoothly connect generally applicable simulation schemes (in which it is necessary to include backtracking processes in the loop construction) to more restricted loop algorithms that can be constructed only for a limited range of Hamiltonians (where backtracking can be avoided). The "algorithmic discontinuities" between general and special points (or regions) in parameter space can hence be eliminated. As a specific example, we consider the anisotropic S=1/2 Heisenberg antiferromagnet in an external magnetic field. We show that directed-loop simulations are very efficient for the full range of magnetic fields (zero to the saturation point) and anisotropies. In particular, for weak fields and anisotropies, the autocorrelations are significantly reduced relative to those of previous approaches. The back-tracking probability vanishes continuously as the isotropic Heisenberg point is approached. For the XY model, we show that back tracking can be avoided for all fields extending up to the saturation field. The method is hence particularly efficient in this case. We use directed-loop simulations to study the magnetization process in the two-dimensional Heisenberg model at very low temperatures. For LxL lattices with L up to 64, we utilize the step structure in the magnetization curve to extract gaps between different spin sectors. Finite-size scaling of the gaps gives an accurate estimate of the transverse susceptibility in the thermodynamic limit: chi( perpendicular )=0.0659+/-0.0002.
Coronal Loops: Observations and Modeling of Confined Plasma
Fabio Reale
2014-07-01
Full Text Available Coronal loops are the building blocks of the X-ray bright solar corona. They owe their brightness to the dense confined plasma, and this review focuses on loops mostly as structures confining plasma. After a brief historical overview, the review is divided into two separate but not independent parts: the first illustrates the observational framework, the second reviews the theoretical knowledge. Quiescent loops and their confined plasma are considered and, therefore, topics such as loop oscillations and flaring loops (except for non-solar ones, which provide information on stellar loops are not specifically addressed here. The observational section discusses the classification, populations, and the morphology of coronal loops, its relationship with the magnetic field, and the loop stranded structure. The section continues with the thermal properties and diagnostics of the loop plasma, according to the classification into hot, warm, and cool loops. Then, temporal analyses of loops and the observations of plasma dynamics, hot and cool flows, and waves are illustrated. In the modeling section, some basics of loop physics are provided, supplying fundamental scaling laws and timescales, a useful tool for consultation. The concept of loop modeling is introduced and models are divided into those treating loops as monolithic and static, and those resolving loops into thin and dynamic strands. More specific discussions address modeling the loop fine structure and the plasma flowing along the loops. Special attention is devoted to the question of loop heating, with separate discussion of wave (AC and impulsive (DC heating. Large-scale models including atmosphere boxes and the magnetic field are also discussed. Finally, a brief discussion about stellar coronal loops is followed by highlights and open questions.
Karlický, M.; Jelínek, P.
2016-05-01
Aims: During the impulsive flare phase, the plasma at the flare loop footpoints is rapidly heated by particle beams. In the present paper, we study processes that occur after this sudden heating in a two-dimensional magnetic loop. Methods: We adopt a 2D magnetohydrodynamic (MHD) model, in which we solve a full set of the ideal time-dependent MHD equations by means of the FLASH code, using the adaptive mesh refinement (AMR) method. Periods in the processes are estimated by the wavelet analysis technique. Results: We consider a model of the solar atmosphere with a symmetric magnetic loop. The length of this loop in the corona is approximately 21.5 Mm. At both loop footpoints, at the transition region, we initiate the Gaussian temperature (pressure) perturbation with the maximum temperature 14, 7, or 3.5 times higher than the unperturbed temperature. In the corona, the perturbations produce supersonic blast shocks with the Mach number of about 1.1, but well below Alfvén velocities. We consider cases with the same perturbations at both footpoints (symmetric case) and one with different perturbations (asymmetric case). In the symmetric case, the shocks move along both loop legs upwards to the top of the loop, where they interact and form a transient compressed region. Then they continue in their motion to the transition region at the opposite side of the loop, where they are reflected upwards, and so on. At the top of the loop, the shock appears periodically with the period of about 170 s. In the loop legs during this period, a double peak of the plasma parameters, which is connected with two arrivals of shocks, is detected: firstly, when the shock moves up and then when the shock, propagating from the opposite loop leg, moves down. Increasing the distance of the detection point in the loop leg from the top of the loop, the time interval between these shock arrivals increases. Thus, at these detection points, the processes with shorter periods can be detected. After
60-GHz CMOS phase-locked loops
Cheema, Hammad M; van Roermund, Arthur HM
2010-01-01
The promising high data rate wireless applications at millimeter wave frequencies in general and 60 GHz in particular have gained much attention in recent years. However, challenges related to circuit, layout and measurements during mm-wave CMOS IC design have to be overcome before they can become viable for mass market. ""60-GHz CMOS Phase-Locked Loops"" focusing on phase-locked loops for 60 GHz wireless transceivers elaborates these challenges and proposes solutions for them. The system level design to circuit level implementation of the complete PLL, along with separate implementations of i
Wilson Loops in Noncommutative Yang Mills
Ishibashi, N; Kawai, H; Kitazawa, Y; Ishibashi, Nobuyuki; Iso, Satoshi; Kawai, Hikaru; Kitazawa, Yoshihisa
2000-01-01
We study the correlation functions of the Wilson loops in noncommutative Yang-Mills theory based upon its equivalence to twisted reduced models. We point out that there is a crossover at the noncommutativity scale. At large momentum scale, the Wilson loops in noncommmutative Yang-Mills represent extended objects. They coincide with those in ordinary Yang-Mills theory in low energy limit. The correlation functions on D-branes in IIB matrix model exhibit the identical crossover behavior. It is observed to be consistent with the supergravity description with running string coupling. We also explain that the results of Seiberg and Witten can be simply understood in our formalism.
Spontaneous fluxoid formation in superconducting loops
Monaco, R.; Mygind, Jesper; Rivers, R.
2009-01-01
a scaling relation on the quenching time τQ, as one would expect if the transition took place as fast as causality permits. However, the observed Zurek-Kibble scaling exponent σ=0.62±0.15 is two times larger than anticipated for large loops. Assuming Gaussian winding number densities we show......We report on the experimental verification of the Zurek-Kibble scenario in an isolated superconducting ring over a wide parameter range. The probability of creating a single flux quantum spontaneously during the fast normal-superconducting phase transition of a wide Nb loop clearly follows...
Designing of optimal double loop networks
徐俊明
1999-01-01
The double loop network G(N; r, s) has N vertices and 2N directed edges. A natural question is how to choose r and s such that G(N; r, s) has diameter as short as possible for a given N. In 1993, Li, Xu and Zhang proposed a method of constructing double loop networks with the minimum diameter for the case of r=1.The method is developed to construct such networks that none of their minimum diameters can be reached at r=1.As a by-product, a flaw in an assertation by Esqu et al. is pointed out.
Classical Loop Actions of Gauge Theories
Armand-Ugon, D; Griego, J R; Setaro, L; Armand-Ugon, Daniel; Gambini, Rodolfo; Griego, Jorge; Setaro, Leonardo
1994-01-01
Since the first attempts to quantize Gauge Theories and Gravity in the loop representation, the problem of the determination of the corresponding classical actions has been raised. Here we propose a general procedure to determine these actions and we explicitly apply it in the case of electromagnetism. Going to the lattice we show that the electromagnetic action in terms of loops is equivalent to the Wilson action, allowing to do Montecarlo calculations in a gauge invariant way. In the continuum these actions need to be regularized and they are the natural candidates to describe the theory in a ``confining phase''.
Loop Optimization for Tensor Network Renormalization
Yang, Shuo; Gu, Zheng-Cheng; Wen, Xiao-Gang
2017-03-01
We introduce a tensor renormalization group scheme for coarse graining a two-dimensional tensor network that can be successfully applied to both classical and quantum systems on and off criticality. The key innovation in our scheme is to deform a 2D tensor network into small loops and then optimize the tensors on each loop. In this way, we remove short-range entanglement at each iteration step and significantly improve the accuracy and stability of the renormalization flow. We demonstrate our algorithm in the classical Ising model and a frustrated 2D quantum model.
Feki, Saber
2017-01-07
The purpose of this chapter is to help OpenACC developer who is already familiar with the basic and essential directives to further improve his code performance by adding more descriptive clauses to OpenACC loop constructs. At the end of this chapter the reader will: • Have a better understanding of the purpose of the OpenACC loop construct and its associated clauses illustrated with use cases • Use the acquired knowledge in practice to further improve the performance of OpenACC accelerated codes
On closed loop transient response system identification
Christer Dalen
2016-10-01
Full Text Available Some methods for transient closed loop step response system identification presented in the literature are reviewed. Interestingly some errors in a method published in the early 80's where propagated into a recently published method. These methods are reviewed and some improved methods are suggested and presented. The methods are compared against each other on some closed loop system examples, e.g. a well pipeline-riser severe-slugging flow regime example, using Monte Carlo simulations for comparison of the methods.
Slipping magnetic reconnection in coronal loops.
Aulanier, Guillaume; Golub, Leon; Deluca, Edward E; Cirtain, Jonathan W; Kano, Ryouhei; Lundquist, Loraine L; Narukage, Noriyuki; Sakao, Taro; Weber, Mark A
2007-12-07
Magnetic reconnection of solar coronal loops is the main process that causes solar flares and possibly coronal heating. In the standard model, magnetic field lines break and reconnect instantaneously at places where the field mapping is discontinuous. However, another mode may operate where the magnetic field mapping is continuous but shows steep gradients: The field lines may slip across each other. Soft x-ray observations of fast bidirectional motions of coronal loops, observed by the Hinode spacecraft, support the existence of this slipping magnetic reconnection regime in the Sun's corona. This basic process should be considered when interpreting reconnection, both on the Sun and in laboratory-based plasma experiments.
Single quark entropy and the Polyakov loop
Weber, Johannes Heinrich
2016-01-01
We study Quantum Chromodynamics (QCD) with 2+1 flavors with almost physical quark masses using the highly improved staggered quark action (HISQ). We calculate the Polyakov loop in a wide temperature range, obtain the free energy and the entropy of a single static quark and discuss the QCD crossover region in detail. We show that the entropy has a peak close to the chiral crossover and consider the consequences for the deconfinement aspects of the crossover phenomena. We study the renormalized Polyakov loop susceptibilities and place them into the context of the crossover. We also obtain a quantitative result for the onset of weak coupling behavior at high temperatures.
Center-vortex loops with one selfintersection
Moosmann, Julain
2008-01-01
We investigate the 2D behavior of one-fold selfintersecting, topologically stabilized center-vortex loops in the confining phase of an SU(2) Yang-Mills theory. This coarse-graining is described by curve-shrinking evolution of center-vortex loops immersed in a flat 2D plane driving the renormalization-group flow of an effective `action'. We observe that the system evolves into a highly ordered state at finite noise level, and we speculate that this feature is connected with 2D planar high $T_c$ superconductivity in $FeAs$ systems.
Non-standard loop quantum cosmology
Piechocki, Wlodzimierz
2010-01-01
We present results concerning the nature of the cosmological big bounce(BB) transition within the loop geometry underlying loop quantum cosmology (LQC). Our canonical quantization method is an alternative to the standard LQC. An evolution parameter we use has clear interpretation both at classical and quantum levels. The physical volume operator has discrete spectrum which is bounded from below. The minimum gap in the spectrum defines a quantum of the volume. The spectra of operators are parametrized by a free parameter to be determined.
Minimal Superstrings and Loop Gas Models
Gaiotto, D; Takayanagi, T; Gaiotto, Davide; Rastelli, Leonardo; Takayanagi, Tadashi
2005-01-01
We reformulate the matrix models of minimal superstrings as loop gas models on random surfaces. In the continuum limit, this leads to the identification of minimal superstrings with certain bosonic string theories, to all orders in the genus expansion. RR vertex operators arise as operators in a Z_2 twisted sector of the matter CFT. We show how the loop gas model implements the sum over spin structures expected from the continuum RNS formulation. Open string boundary conditions are also more transparent in this language.
Reverse Loop subdivision with sharp features
Zhao Mingxi; Ma Lizhuang; Mao Zhihong; Wu Xiaomao
2006-01-01
In this paper we introduce a new reverse Loop subdivision method. In contrast to current wavelets based Loop subdivision scheme, our method applies the same rules to both regular and extraordinary vertices and reconstructs the sharp features easily. Furthermore, our method runs faster because it does not need analysis and synthesis procedural. Our main goal is the design of a reverse subdivision method that can reconstruct the coarser mesh from a finer subdivision surface with sharp features for multiresolution representation. The proposed method only needs a little memory storage and brings little error, and it is easy to implement.
Perturbative loop corrections and nonlocal gravity
Maggiore, Michele
2016-01-01
Nonlocal gravity has been shown to provide a phenomenologically viable infrared modification of GR. A natural question is whether the required nonlocality can emerge from perturbative quantum loop corrections due to light particles. We show that this is not the case. For the value of the mass scale of the non-local models required by cosmology, the perturbative form factors obtained from the loop corrections, in the present cosmological epoch, are in the regime where they are local. The mechanism behind the generation of the required nonlocality must be more complex, possibly related to strong infrared effects and non-perturbative mass generation for the conformal mode.
Loop Quantum Cosmology: Anisotropy and singularity resolution
Corichi, Alejandro; Montoya, Edison
2012-01-01
In this contribution we consider the issue of singularity resolution within loop quantum cosmology (LQC) for different homogeneous models. We present results of numerical evolutions of effective equations for both isotropic as well as anisotropic cosmologies, with and without spatial curvature. To address the issue of singularity resolution we examine the time evolution of geometrical and curvature invariants that yield information about the semiclassical spacetime geometry. We discuss generic behavior found for a variety of initial conditions. Finally, we show that the modifications which come from Loop Quantum Cosmology imply a non-chaotic effective behavior in the vacuum Bianchi IX model.
Loop Optimization for Tensor Network Renormalization.
Yang, Shuo; Gu, Zheng-Cheng; Wen, Xiao-Gang
2017-03-17
We introduce a tensor renormalization group scheme for coarse graining a two-dimensional tensor network that can be successfully applied to both classical and quantum systems on and off criticality. The key innovation in our scheme is to deform a 2D tensor network into small loops and then optimize the tensors on each loop. In this way, we remove short-range entanglement at each iteration step and significantly improve the accuracy and stability of the renormalization flow. We demonstrate our algorithm in the classical Ising model and a frustrated 2D quantum model.
Effective constraints of loop quantum gravity
Bojowald, M; Kagan, M; Skirzewski, A; Bojowald, Martin; Hernandez, Hector; Kagan, Mikhail; Skirzewski, Aureliano
2006-01-01
Within a perturbative cosmological regime of loop quantum gravity corrections to effective constraints are computed. This takes into account all inhomogeneous degrees of freedom relevant for scalar metric modes around flat space and results in explicit expressions for modified coefficients and of higher order terms. It also illustrates the role of different scales determining the relative magnitude of corrections. Our results demonstrate that loop quantum gravity has the correct classical limit, at least in its sector of cosmological perturbations around flat space, in the sense of perturbative effective theory.
Loops in canonical RNA pseudoknot structures
Nebel, Markus E; Wang, Rita R
2009-01-01
In this paper we compute the limit distributions of the numbers of hairpin-loops, interior-loops and bulges in k-noncrossing RNA structures. The latter are coarse grained RNA structures allowing for cross-serial interactions, subject to the constraint that there are at most k-1 mutually crossing arcs in the diagram representation of the molecule. We prove central limit theorems by means of studying the corresponding bivariate generating functions. These generating functions are obtained by symbolic inflation of Ik5-shapes.
A True Open-Loop Synchronization Technique
Golestan, Saeed; Vidal, Ana; Yepes, Alejandro G.
2016-01-01
to worsen in the presence of frequency drifts. To deal with this problem, two approaches are often recommended in the literature: Adapting OLS techniques to grid frequency variations by feeding back the frequency estimated by them or using the frequency estimated by a secondary frequency detector...... in a parallel manner. In the presence of the frequency feedback loop, nevertheless, the OLS technique may not be truly open-loop, which makes a deep study of stability necessary. Using the secondary frequency detector, on the other hand, increases the computational effort and implementation complexity. Another...
Martinez-Guridi, G.; Samanta, P.; Chu, L.; Yang, J. [Brookhaven National Lab., Upton, NY (United States)
1998-03-01
Generic Safety Issue 171 (GSI-171), Engineered Safety Feature (ESF) from a Loss Of Offsite Power (LOOP) subsequent to a Loss Of Coolant Accident (LOCA), deals with an accident sequence in which a LOCA is followed by a LOOP. This issue was later broadened to include a LOOP followed by a LOCA. Plants are designed to handle a simultaneous LOCA and LOOP. In this paper, the authors address the unique issues that are involved i LOCA with delayed LOOP (LOCA/LOOP) and LOOP with delayed LOCA (LOOP/LOCA) accident sequences. LOCA/LOOP accidents are analyzed further by developing event-tree/fault-tree models to quantify their contributions to core-damage frequency (CDF) in a pressurized water reactor and a boiling water reactor (PWR and a BWR). Engineering evaluation and judgments are used during quantification to estimate the unique conditions that arise in a LOCA/LOOP accident. The results show that the CDF contribution of such an accident can be a dominant contributor to plant risk, although BWRs are less vulnerable than PWRs.
A Digital Phase Lock Loop for an External Cavity Diode Laser
WANG Xiao-Long; TAO Tian-Jiong; CHENG Bing; WU Bin; XU Yun-Fei; WANG Zhao-Ying; LIN Qiang
2011-01-01
@@ A digital optical phase lock loop (OPLL) is implemented to synchronize the frequency and phase between two external cavity diode lasers (ECDL), generating Raman pulses for atom interferometry.The setup involves alldigital phase detection and a programmable digital proportional-integral-derivative (PID) loop in locking.The lock generates a narrow beat-note linewidth below 1 Hz and low phase-noise of 0.03rad2 between the master and slave ECDLs.The lock proves to be stable and robust, and all the locking parameters can be set and optimized on a computer interface with convenience, making the lock adaptable to various setups of laser systems.
A Digital Phase Lock Loop for an External Cavity Diode Laser
Wang, Xiao-Long; Tao, Tian-Jiong; Cheng, Bing; Wu, Bin; Xu, Yun-Fei; Wang, Zhao-Ying; Lin, Qiang
2011-08-01
A digital optical phase lock loop (OPLL) is implemented to synchronize the frequency and phase between two external cavity diode lasers (ECDL), generating Raman pulses for atom interferometry. The setup involves all-digital phase detection and a programmable digital proportional-integral-derivative (PID) loop in locking. The lock generates a narrow beat-note linewidth below 1 Hz and low phase-noise of 0.03rad2 between the master and slave ECDLs. The lock proves to be stable and robust, and all the locking parameters can be set and optimized on a computer interface with convenience, making the lock adaptable to various setups of laser systems.
One loop photon-graviton mixing in an electromagnetic field: Part 1
Bastianelli, F; Bastianelli, Fiorenzo; Schubert, Christian
2005-01-01
Photon-graviton mixing in an electromagnetic field is a process of potential interest for cosmology and astrophysics. At the tree level it has been studied by many authors. We consider the one-loop contribution to this amplitude involving a charged spin 0 or spin 1/2 particle in the loop and an arbitrary constant field. In the first part of this article, the worldline formalism is used to obtain a compact two-parameter integral representation for this amplitude, valid for arbitrary photon energies and background field strengths. The calculation is manifestly covariant througout.
Two loop effective Kähler potential of (non-)renormalizable supersymmetric models
Nibbelink, S G; Nibbelink, Stefan Groot; Nyawelo, Tino S.
2006-01-01
We perform a supergraph computation of the effective Kaehler potential at one and two loops for general four dimensional N=1 supersymmetric theories described by arbitrary Kaehler potential, superpotential and gauge kinetic function. We only insist on gauge invariance of the Kaehler potential and the superpotential as we heavily rely on its consequences in the quantum theory. However, we do not require gauge invariance for the gauge kinetic functions, so that our results can also be applied to anomalous theories that involve the Green-Schwarz mechanism. We illustrate our two loop results by considering a few simple models: the (non-)renormalizable Wess-Zumino model and Super Quantum Electrodynamics.
Loop electrostatics modulates the intersubunit interactions in ferritin.
Bernacchioni, Caterina; Ghini, Veronica; Pozzi, Cecilia; Di Pisa, Flavio; Theil, Elizabeth C; Turano, Paola
2014-11-21
Functional ferritins are 24-mer nanocages that self-assemble with extended contacts between pairs of 4-helix bundle subunits coupled in an antiparallel fashion along the C2 axes. The largest intersubunit interaction surface in the ferritin nanocage involves helices, but contacts also occur between groups of three residues midway in the long, solvent-exposed L-loops of facing subunits. The anchor points between intersubunit L-loop pairs are the salt bridges between the symmetry-related, conserved residues Asp80 and Lys82. The resulting quaternary structure of the cage is highly soluble and thermostable. Substitution of negatively charged Asp80 with a positively charged Lys in homopolymeric M ferritin introduces electrostatic repulsions that inhibit the oligomerization of the ferritin subunits. D80K ferritin was present in inclusion bodies under standard overexpressing conditions in E. coli, contrasting with the wild type protein. Small amounts of fully functional D80K nanocages formed when expression was slowed. The more positively charged surface results in a different solubility profile and D80K crystallized in a crystal form with a low density packing. The 3D structure of D80K variant is the same as wild type except for the side chain orientations of Lys80 and facing Lys82. When three contiguous Lys groups are introduced in D80KI81K ferritin variant the nanocage assembly is further inhibited leading to lower solubility and reduced thermal stability. Here, we demonstrate that the electrostatic pairing at the center of the L-loops has a specific kinetic role in the self-assembly of ferritin nanocages.
Toskes, P P; Giannella, R A; Jervis, H R; Rout, W R; Takeuchi, A
1975-05-01
Microscopic (light and electron) and histochemical abnormalities have been demonstrated in the jejunum of rats with the blind loop syndrome. Three groups of animals were studied: normal control animals, and animals with either self-filling (SF) or self-emptying (SE) blind loops. Vitamin B12 malabsorption and bacterial overgrowth occurred only in those animals with SF blind loops. Three jejunal segments were studied: the blind loop segment and the jejunal segments proximal and distal to the blind loop. In the animals with the blind loop syndrome, those with SF blind loops, the most striking findings occurred in the blind loop itself, with similar but less marked changes in the jejunum distal but not proximal to the blind loop segment. Hypertrophy of both crypts and villi was evident with focal abnormalities of villus architecture. Approximately 10 to 20% of the columnar cells in the upper half of the villi were swollen and vesiculated. By electron microscopy microvilli demonstrated a variety of degeneration changes and the glycocalyx and terminal web were disrupted. Mitochondria and endoplasmic reticulum (ER), both smooth and rough, were swollen. Concentric whorls of parallel membranes and long, curvilinear rough ER were present in the cytoplasm. Histochemically, there was loss of enzymatic activity in the epithelial brush border, mitochondria and ER. Inasmuch as bacterial invasion of the jejunal mucosa was not seen, the etiology of these changes is not known but may involve bacterial "toxins" or products of bacterial metabolism. These morphological observations demonstrate that both brush border and intracellular injury occur in the jejunal epithelial cell of rats with the experimental blind loop syndrome.
The Extended Loop Group An Infinite Dimensional Manifold Associated with the Loop Space
Di Bartolo, C; Griego, J R; Bartolo, Cayetano Di; Gambini, Rodolfo; Griego, Jorge
1993-01-01
A set of coordinates in the non parametric loop-space is introduced. We show that these coordinates transform under infinite dimensional linear representations of the diffeomorphism group. An extension of the group of loops in terms of these objects is proposed. The enlarged group behaves locally as an infinite dimensional Lie group. Ordinary loops form a subgroup of this group. The algebraic properties of this new mathematical structure are analized in detail. Applications of the formalism to field theory, quantum gravity and knot theory are considered.
Fiber reinforced composite loop space maintainer: An alternative to the conventional band and loop
Ramakrishna Yeluri
2012-01-01
Full Text Available The stainless steel band and loop appliance is the most commonly used fixed space maintainer in pediatric dentistry. But there are several disadvantages with this appliance such as the need for a cast or a working model, decalcification of the abutment tooth, loosening because of breakage or dissolution of the luting agent, tendency to get embedded in the soft tissue and the possibility of metal allergy. The purpose of this article is to present a simple, laboratory design of a "Fiber Reinforced Composite" (FRC loop space maintainer and discuss the advantages over the traditional band and loop space maintainers.
Fiber reinforced composite loop space maintainer: An alternative to the conventional band and loop.
Yeluri, Ramakrishna; Munshi, Autar Krishen
2012-04-01
The stainless steel band and loop appliance is the most commonly used fixed space maintainer in pediatric dentistry. But there are several disadvantages with this appliance such as the need for a cast or a working model, decalcification of the abutment tooth, loosening because of breakage or dissolution of the luting agent, tendency to get embedded in the soft tissue and the possibility of metal allergy. The purpose of this article is to present a simple, laboratory design of a "Fiber Reinforced Composite" (FRC) loop space maintainer and discuss the advantages over the traditional band and loop space maintainers.
Generalized Loop Space and Evolution of the Light-Like Wilson Loops
Cherednikov, I O
2014-01-01
Equations of motion for the light-like QCD Wilson loops are studied in the generalized loop space (GLS) setting. To this end, the classically conformal-invariant non-local variations of the cusped Wilson exponentials lying (partially) on the light-cone are formulated in terms of the Fr\\'echet derivative. The rapidity and renormalization-group behaviour of the gauge-invariant quantum correlation functions (in particular, the three-dimensional parton densities) are demonstrated to be connected to certain geometrical properties of the Wilson loops defined in the GLS.
Quantum hysteresis loops in microscopic system: The loop area as a dynamical parameter
Chandan Kumar Mondal; S P Bhattacharyya
2001-01-01
The area enclosed by hysteresis loops in a periodically forced bistable microscopic system at zero-temperature is examined by using the time dependent Hellmann–Feynman theorem and the Fourier grid Hamiltonian recipe for solving time-dependent Schrödinger equation. Effects of non-zero temperatures are explored with reference to a symmetric double well potential. The barrier crossing or, relaxation rates are shown to correlate systematically with the area of the loop. The possible use of hysteresis loop area in designing ﬁeld parameters for optimal control is suggested.
Parikshit Rajkumar Rao
2013-01-01
Results: Inherently the M/F ratio produced was higher and F/D rate produced was least for opus loop compared to snail loop and teardrop loop. Conclusion: With incorporation of 20°gable bends snail loop prepared in 0.017 × 0.025 inch and 0.019 × 0.025 inch TMA wire is very efficient to deliver M/F ratio required for translatory tooth movement with acceptable F/D rate. Snail loop is easy to fabricate and finer shape morphology prevents tissue impingement.
Designing Self-Organized Contextualized Feedback Loops
Kalz, Marco
2013-01-01
Kalz, M. (2013). Designing Self-Organized Contextualized Feedback Loops. In D. Whitelock, W. Warburton, G. Wills, & L. Gilbert (Eds.), International Conference on Computer Assisted Assessment (CAA 2013). July, 9-10, 2013, University of Southampton, Southampton, UK. http://caaconference.com.
Calculating Electromagnetic Fields Of A Loop Antenna
Schieffer, Mitchell B.
1987-01-01
Approximate field values computed rapidly. MODEL computer program developed to calculate electromagnetic field values of large loop antenna at all distances to observation point. Antenna assumed to be in x-y plane with center at origin of coordinate system. Calculates field values in both rectangular and spherical components. Also solves for wave impedance. Written in MicroSoft FORTRAN 77.
The Alpine loop of the tethys zone
Bemmelen, R.W. van
1969-01-01
The Alpine loop in Europe results from semi-autochthonous crustal movements which are restricted to the mobile Tethys zone. Its evolution cannot be explained by a uniform northward drift and push of the African continent; it has to be sought, in the first place, in geodynamic processes occurring in
Black hole entropy in loop quantum gravity
Agulló, Iván; Barbero G, J. Fernando; Borja, E. F.; Díaz-Polo, Jacobo; Villaseñor, Eduardo J. S.
2012-05-01
We discuss the recent progress on black hole entropy in loop quantum gravity, focusing in particular on the recently discovered discretization effect for microscopic black holes. Powerful analytical techniques have been developed to perform the exact computation of entropy. A statistical analysis of the structures responsible for this effect shows its progressive damping and eventual disappearance as one increases the considered horizon area.
Closed-loop control of magnetotactic bacteria
Khalil, I.S.M.; Pichel, M.P.; Abelmann, L.; Misra, S.
2013-01-01
Realization of point-to-point positioning of a magnetotactic bacterium (MTB) necessitates the application of a relatively large magnetic field gradients to decrease its velocity in the vicinity of a reference position. We investigate an alternative closed-loop control approach to position the MTB. T
Loop quantum gravity; Gravedad cuantica de lazos
Pullin, J.
2015-07-01
Loop quantum gravity is one of the approaches that are being studied to apply the rules of quantum mechanics to the gravitational field described by the theory of General Relativity . We present an introductory summary of the main ideas and recent results. (Author)
Polyakov Loop Correlations at Large N
Neuberger, Herbert
2014-01-01
I describe a study of the two-point single-eigenvalue distribution correlation function of Polyakov loops in the confined phase of four dimensional SU(N) YM theory at large N. The reasons for the interest in this correlation function are explained. Analytical and numerical results are presented. Brief conclusions are drawn.
Fun with higher-loop Feynman diagrams
Luthe, Thomas; Schröder, York
2016-10-01
We review recent progress that we have achieved in evaluating the class of fully massive vacuum integrals at five loops. After discussing topics that arise in classification, evaluation and algorithmic codification of this specific set of Feynman integrals, we present some selected new results for their expansions around 4 — 2ε dimensions.
Loop Quantum Cosmology and the CMB
Agullo, Ivan
2017-01-01
This talk will provide an up-to-date summary of phenomenological explorations in loop quantum cosmology. The possibility of a quantum gravity origin of the anomalies observed in the cosmic microwave background at large angular scales will be discussed. The talk will also provide some background material for subsequent contributions in the same session. NSF PHYS-1403943.
Think Math! Interactive Loops for Groups.
Bulla, Dale
This book contains activities using a technique that allows students to practice routine arithmetical operations without getting bored. Math Loops is a game in which each student receives a card containing answers to a mathematics question or problem and must listen for another student to call out the question. As the game progresses around the…
Geometry of the analytic loop group
De Concini, C.; Hernandez, D.; Reshetikhin, N.
2013-01-01
We introduce and study a notion of analytic loop group with a Riemann-Hilbert factorization relevant for the representation theory of quantum affine algebras at roots of unity View the MathML source with non-trivial central charge. We introduce a Poisson structure and study properties of its Poisson
Quenched chiral perturbation theory to one loop
Colangelo, Gilberto; Pallante, Elisabetta
1998-01-01
We calculate the divergences of the generating functional of quenched chiral perturbation theory at one loop, and renormalize the theory by an appropriate definition of the counterterms. We show that the quenched chiral logarithms can be accounted for by defining a renormalized B0 parameter which, a
Quenched Chiral Perturbation Theory to one loop
Colangelo, G.; Pallante, E.
1998-01-01
The divergences of the generating functional of quenched Chiral Perturbation theory (qCHPT) to one loop are computed in closed form. We show how the quenched chiral logarithms can be reabsorbed in the renormalization of the B0 parameter of the leading order Lagrangian. Finally, we do the chiral powe
Volume reduction through perturbative Wilson loops
Perez, Margarita Garcia; Okawa, Masanori
2016-01-01
We derive the perturbative expansion of Wilson loops to order g^4 in a SU(N) lattice gauge theory with twisted boundary conditions. Our expressions show that the thermodynamic limit is attained at infinite N for any number of lattice sites and allow to quantify the deviations from volume independence at finite large N as a function of the twist.
Phase locked loops design, simulation, and applications
Best, Roland E
2007-01-01
The Definitive Introduction to Phase-Locked Loops, Complete with Software for Designing Wireless Circuits! The Sixth Edition of Roland Best's classic Phase-Locked Loops has been updated to equip you with today's definitive introduction to PLL design, complete with powerful PLL design and simulation software written by the author. Filled with all the latest PLL advances, this celebrated sourcebook now includes new chapters on frequency synthesis…CAD for PLLs…mixed-signal PLLs…all-digital PLLs…and software PLLs_plus a new collection of sample communications applications. An essential tool for achieving cutting-edge PLL design, the Sixth Edition of Phase-Locked Loops features: A wealth of easy-to-use methods for designing phase-locked loops Over 200 detailed illustrations New to this edition: new chapters on frequency synthesis, including fractional-N PLL frequency synthesizers using sigma-delta modulators; CAD for PLLs, mixed-signal PLLs, all-digital PLLs, and software PLLs; new PLL communications ap...
Polynomial structures in one-loop amplitudes
Britto, R.; Feng, B.; Yang, G.
2008-01-01
A general one-loop scattering amplitude may be expanded in terms of master integrals. The coefficients of the master integrals can be obtained from tree-level input in a two-step process. First, use known formulas to write the coefficients of (4-2epsilon)-dimensional master integrals; these formulas
Integral coefficients for one-loop amplitudes
Britto, R.; Feng, B.
2008-01-01
We present a set of algebraic functions for evaluating the coefficients of the scalar integral basis of a general one-loop amplitude. The functions are derived from unitarity cuts, but the complete cut-integral procedure has been carried out in generality so that it never needs to be repeated. Where
Aesthetic rehabilitation with multiple loop connectors
Ashish Kalra
2013-01-01
Full Text Available Patients with a missing tooth along with diastema have limited treatment options to restore the edentulous space. The use of a conventional fixed partial denture (FPD to replace the missing tooth may result in too wide anterior teeth leading to poor esthetics. The diastema resulting from the missing central incisors can be managed with implant-supported prosthesis or FPD with loop connectors. An old lady reported with chief complaints of missing upper anterior teeth due to trauma. Her past dental history revealed that she was having generalized spacing between her upper anterior teeth. Considering her esthetic requirement of maintaining the diastema between 12, 11, 22, and 21, the treatment option of 06 units porcelain fused to metal FPD from canine to canine with intermittent loop connectors between 21, 22, 11, 12 was planned. Connectors basically link different parts of FPDs. The modified FPD with loop connectors enhanced the natural appearance of the restoration, maintained the diastemas and the proper emergence profile, and preserve the remaining tooth structure of abutment teeth. This clinical report discussed a method for fabrication of a modified FPD with loop connectors to restore the wide span created by missing central incisors.
Closed Loop System Identification with Genetic Algorithms
Whorton, Mark S.
2004-01-01
High performance control design for a flexible space structure is challenging since high fidelity plant models are di.cult to obtain a priori. Uncertainty in the control design models typically require a very robust, low performance control design which must be tuned on-orbit to achieve the required performance. Closed loop system identi.cation is often required to obtain a multivariable open loop plant model based on closed-loop response data. In order to provide an accurate initial plant model to guarantee convergence for standard local optimization methods, this paper presents a global parameter optimization method using genetic algorithms. A minimal representation of the state space dynamics is employed to mitigate the non-uniqueness and over-parameterization of general state space realizations. This control-relevant system identi.cation procedure stresses the joint nature of the system identi.cation and control design problem by seeking to obtain a model that minimizes the di.erence between the predicted and actual closed-loop performance.
Closing the loop: towards strategic defence management
S. de Spiegeleire; P. van Hooft; C. Culpepper; R. Willems
2009-01-01
How do defence-organisations (or organisations with comparable profiles) of other countries map out policy goals and how are policy goals related to activities and capabilities and the required financial means, and finally how does the feedback loop on the performance in all these areas take place?
Selective purge for hydrogenation reactor recycle loop
Baker, Richard W.; Lokhandwala, Kaaeid A.
2001-01-01
Processes and apparatus for providing improved contaminant removal and hydrogen recovery in hydrogenation reactors, particularly in refineries and petrochemical plants. The improved contaminant removal is achieved by selective purging, by passing gases in the hydrogenation reactor recycle loop or purge stream across membranes selective in favor of the contaminant over hydrogen.
String loop corrected hypermultiplet moduli spaces
Robles-Llana, D.; Saueressig, Frank; Vandoren, S.
2007-01-01
Using constraints from supersymmetry and string perturbation theory, we determine the string loop corrections to the hypermultiplet moduli space of type II strings compactified on a generic Calabi-Yau threefold. The corresponding quaternion-Kähler manifolds are completely encoded in terms of a singl
Abelian Duality and Abelian Wilson Loops
Zucchini, R
2003-01-01
We consider a pure U(1) quantum gauge field theory on a general Riemannian compact four manifold. We compute the partition function with Abelian Wilson loop insertions. We find its duality covariance properties and derive topological selection rules. Finally, we show that, to have manifest duality, one must assume the existence of twisted topological sectors besides the standard untwisted one.
Semiclassical analysis of loop quantum gravity
Conrady, F.
2005-10-17
In this Ph.D. thesis, we explore and develop new methods that should help in determining an effective semiclassical description of canonical loop quantum gravity and spin foam gravity. A brief introduction to loop quantum gravity is followed by three research papers that present the results of the Ph.D. project. In the first article, we deal with the problem of time and a new proposal for implementing proper time as boundary conditions in a sum over histories: we investigate a concrete realization of this formalism for free scalar field theory. In the second article, we translate semiclassical states of linearized gravity into states of loop quantum gravity. The properties of the latter indicate how semiclassicality manifests itself in the loop framework, and how this may be exploited for doing semiclassical expansions. In the third part, we propose a new formulation of spin foam models that is fully triangulation- and background-independent: by means of a symmetry condition, we identify spin foam models whose triangulation-dependence can be naturally removed. (orig.)
Closed-loop control of magnetotactic bacteria
Khalil, I.S.M.; Pichel, Marc Philippe; Pichel, M.P.; Abelmann, Leon; Misra, Sarthak
Realization of point-to-point positioning of a magnetotactic bacterium (MTB) necessitates the application of a relatively large magnetic field gradients to decrease its velocity in the vicinity of a reference position. We investigate an alternative closed-loop control approach to position the MTB.
The Alpine loop of the tethys zone
Bemmelen, R.W. van
1969-01-01
The Alpine loop in Europe results from semi-autochthonous crustal movements which are restricted to the mobile Tethys zone. Its evolution cannot be explained by a uniform northward drift and push of the African continent; it has to be sought, in the first place, in geodynamic processes occurring in
The Early Universe in Loop Quantum Cosmology
Bojowald, M.
2005-01-01
Loop quantum cosmology applies techniques derived for a background independent quantization of general relativity to cosmological situations and draws conclusions for the very early universe. Direct implications for the singularity problem as well as phenomenology in the context of inflation or bouncing universes result, which will be reviewed here. The discussion focuses on recent new results for structure formation and generalizations of the methods.
Application of Carbonate Looping to Cement Industry
Lin, Weigang; Illerup, Jytte Boll; Dam-Johansen, Kim
2012-01-01
of sorbents in carbonate looping processes. The results show that the CO2 carrying capacity of limestone is much lower at realistic conditions than at mild conditions, which are often used in laboratory experiments. BET and SEM analyses show that the surface area of calcined limestone decreases significantly...
Higher loop renormalization of fermion bilinear operators
Skouroupathis, A
2007-01-01
We compute the two-loop renormalization functions, in the RI' scheme, of local bilinear quark operators $\\bar\\psi\\Gamma\\psi$, where $\\Gamma$ denotes the Scalar and Pseudoscalar Dirac matrices, in the lattice formulation of QCD. We consider both the flavor non-singlet and singlet operators; the latter, in the scalar case, leads directly to the two-loop fermion mass renormalization, $Z_m$. As a prerequisite for the above, we also compute the quark field renormalization, $Z_\\psi$, up to two loops. We use the clover action for fermions and the Wilson action for gluons. Our results are given as a polynomial in $c_{SW}$, in terms of both the renormalized and bare coupling constant, in the renormalized Feynman gauge. We also confirm the 1-loop renormalization functions, for generic gauge. A longer write-up of the present work, including the conversion of our results to the MSbar scheme and a generalization to arbitrary fermion representations, can be found in arXiv:0707.2906 .
Two Loop Effective Kähler Potential
Nyawelo, T S; Nyawelo, Tino S.; Nibbelink, Stefan Groot
2007-01-01
In this talk we study the renormalization of the effective Kaehler potential at one and two loops for general four dimensional (non--renormalizable) N=1 supersymmetric theories described by arbitrary Kaehler potential, superpotential and gauge kinetic function. We consider the Wess-Zumino model as an example.
Wilson-Loop Symmetry Breaking Reexamined
Nakamula, Atsushi
2014-01-01
The splitting in energy of gauge field vacua on the non-simply connected space $S^3/Z_2$ is reconsidered. We show the calculation to the one-loop level for a Yang-Mills vector with a ghost field. We confirm our previous result and give a solution to the question posed by Freire, Rom\\~ao and Barroso.
BIOREACTOR DESIGN - OUTER LOOP LANDFILL, LOUISVILLE, KY
Bioreactor field demonstration projects are underway at the Outer Loop Landfill in Louisville, KY, USA. The research effort is a cooperative research effort between US EPA and Waste Management Inc. Two primary kinds of municipal waste bioreactors are under study at this site. ...
Energy Release in Driven Twisted Coronal Loops
Bareford, M. R.; Gordovskyy, M.; Browning, P. K.; Hood, A. W.
2016-01-01
We investigate magnetic reconnection in twisted magnetic fluxtubes, representing coronal loops. The main goal is to establish the influence of the field geometry and various thermodynamic effects on the stability of twisted fluxtubes and on the size and distribution of heated regions. In particular, we aim to investigate to what extent the earlier idealised models, based on the initially cylindrically symmetric fluxtubes, are different from more realistic models, including the large-scale curvature, atmospheric stratification, thermal conduction and other effects. In addition, we compare the roles of Ohmic heating and shock heating in energy conversion during magnetic reconnection in twisted loops. The models with straight fluxtubes show similar distribution of heated plasma during the reconnection: it initially forms a helical shape, which subsequently becomes very fragmented. The heating in these models is rather uniformly distributed along fluxtubes. At the same time, the hot plasma regions in curved loops are asymmetric and concentrated close to the loop tops. Large-scale curvature has a destabilising influence: less twist is needed for instability. Footpoint convergence normally delays the instability slightly, although in some cases, converging fluxtubes can be less stable. Finally, introducing a stratified atmosphere gives rise to decaying wave propagation, which has a destabilising effect.
Wilson-loop symmetry breaking reexamined
Nakamura, A.; Shiraishi, K.
1988-12-01
The splitting in energy of gauge field vacua on the non-simply connected space S 3/Z 2 is reconsidered. We show the calculation to the one-loop level for a Yang-Mills vector with a ghost field. We confirm our previous result and give a solution to the question posed by Freire, Romão and Barroso.
Loop Evolution Observed with AIA and Hi-C
Mulu-Moore, Fana; Winebarger, Amy R.; Cirtain, Jonathan W.; Kobayashi, Ken; Korreck, Kelly E.; Golub, Leon; Kuzin, Sergei; Walsh, Robert William; DeForest, Craig E.; De Pontieu, Bart; Title, Alan M.; Weber, Mark
2012-01-01
In the past decade, the evolution of EUV loops has been used to infer the loop substructure. With the recent launch of High Resolution Coronal Imager (Hi-C), this inference can be validated. In this presentation we discuss the first results of loop analysis comparing AIA and Hi-C data. In the past decade, the evolution of EUV loops has been used to infer the loop substructure. With the recent launch of High Resolution Coronal Imager (Hi-C), this inference can be validated. In this presentation we discuss the first results of loop analysis comparing AIA and Hi-C data.
Gravitational Smoothing of Kinks on Cosmic String Loops
Wachter, Jeremy M.; Olum, Ken D.
2017-02-01
We analyze the effect of gravitational backreaction on cosmic string loops with kinks, which is an important determinant of the shape, and thus the potential observability, of string loops which may exist in the Universe today. Kinks are not rounded off, but may be straightened out. This means that backreaction will only cause loops with kinks to develop cusps after some potentially large fraction of their lifetimes. In some loops, symmetries prevent even this process, so that the loop evaporates in a self-similar fashion and the kinks are unchanged. As an example, we discuss backreaction on the rectangular Garfinkle-Vachaspati loop.
Alterovitz, Gil
2004-01-01
This research analyzed both engineering and nontechnical issues involved in the use of Induction Loop Amplification (ILA) devices in auditoriums or large gathering places for hard-of-hearing individuals. A variety of parameters need to be taken into account to determine an optimal shape/configuration for the ILA device. In many cases, an optimal configuration is different from those proposed for classroom use (Ross, 1969; Hodgson, 1986; Clevenger, 1992). Experimental results were obtained for a double-loop configuration in such a setting (a university gymnasium/auditorium in this case). The results demonstrate that a double-loop configuration is a viable possibility for auditorium use. Several variables using this configuration were examined, and experimentation was done. Various implications, including consequent nontechnical issues specific to this application, are discussed as well. Technical and nontechnical aspects of the ILA configuration need to be examined together when designing an optimal system.
Beyond Quantum interference and Optical pumping: invoking a Closed-loop phase
Kani, A
2016-01-01
Atomic coherence effects arising from coherent light-atom interaction are conventionally known to be governed by quantum interference and optical pumping mechanisms. However, anisotropic nonlinear response driven by optical field involves another fundamental effect arising from closed-loop multiphoton transitions. This closed-loop phase dictates the tensorial structure of the nonlinear susceptibility as it governs the principal coordinate system in determining, whether the light field will either compete or cooperate with the external magnetic field stimulus. Such a treatment provides deeper understanding of all magneto-optical anisotropic response. The magneto-optical response in all atomic systems is classified using closed-loop phase. The role of quantum interference in obtaining electromagnetically induced transparency or electromagnetically induced absorption in multi-level systems is identified.
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang, Fuguo; Taylor, David W; Chen, Janice S; Kornfeld, Jack E; Zhou, Kaihong; Thompson, Aubri J; Nogales, Eva; Doudna, Jennifer A
2016-02-19
Bacterial adaptive immunity and genome engineering involving the CRISPR (clustered regularly interspaced short palindromic repeats)-associated (Cas) protein Cas9 begin with RNA-guided DNA unwinding to form an RNA-DNA hybrid and a displaced DNA strand inside the protein. The role of this R-loop structure in positioning each DNA strand for cleavage by the two Cas9 nuclease domains is unknown. We determine molecular structures of the catalytically active Streptococcus pyogenes Cas9 R-loop that show the displaced DNA strand located near the RuvC nuclease domain active site. These protein-DNA interactions, in turn, position the HNH nuclease domain adjacent to the target DNA strand cleavage site in a conformation essential for concerted DNA cutting. Cas9 bends the DNA helix by 30°, providing the structural distortion needed for R-loop formation.
Structural consequences of cutting a binding loop: two circularly permuted variants of streptavidin
Le Trong, Isolde [University of Washington, Box 357420, Seattle, WA 98195-7420 (United States); University of Washington, Box 357742, Seattle, WA 98195-7742 (United States); Chu, Vano [University of Washington, Box 355061, Seattle, WA 98195-5061 (United States); Xing, Yi [University of Washington, Box 357420, Seattle, WA 98195-7420 (United States); Lybrand, Terry P. [Vanderbilt University, 5142 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8725 (United States); Stayton, Patrick S. [University of Washington, Box 355061, Seattle, WA 98195-5061 (United States); Stenkamp, Ronald E., E-mail: stenkamp@u.washington.edu [University of Washington, Box 357420, Seattle, WA 98195-7420 (United States); University of Washington, Box 357742, Seattle, WA 98195-7742 (United States); University of Washington, Box 357430, Seattle, WA 98195-7430 (United States)
2013-06-01
The crystal structures of two circularly permuted streptavidins probe the role of a flexible loop in the tight binding of biotin. Molecular-dynamics calculations for one of the mutants suggests that increased fluctuations in a hydrogen bond between the protein and biotin are associated with cleavage of the binding loop. Circular permutation of streptavidin was carried out in order to investigate the role of a main-chain amide in stabilizing the high-affinity complex of the protein and biotin. Mutant proteins CP49/48 and CP50/49 were constructed to place new N-termini at residues 49 and 50 in a flexible loop involved in stabilizing the biotin complex. Crystal structures of the two mutants show that half of each loop closes over the binding site, as observed in wild-type streptavidin, while the other half adopts the open conformation found in the unliganded state. The structures are consistent with kinetic and thermodynamic data and indicate that the loop plays a role in enthalpic stabilization of the bound state via the Asn49 amide–biotin hydrogen bond. In wild-type streptavidin, the entropic penalties of immobilizing a flexible portion of the protein to enhance binding are kept to a manageable level by using a contiguous loop of medium length (six residues) which is already constrained by its anchorage to strands of the β-barrel protein. A molecular-dynamics simulation for CP50/49 shows that cleavage of the binding loop results in increased structural fluctuations for Ser45 and that these fluctuations destabilize the streptavidin–biotin complex.
Role of the NC-loop in catalytic activity and stability in lipase from Fervidobacterium changbaicum.
Binchun Li
Full Text Available Flexible NC-loops between the catalytic domain and the cap domain of the α/β hydrolase fold enzymes show remarkable diversity in length, sequence, and configuration. Recent investigations have suggested that the NC-loop might be involved in catalysis and substrate recognition in many enzymes from the α/β hydrolase fold superfamily. To foster a deep understanding of its role in catalysis, stability, and divergent evolution, we here systemically investigated the function of the NC-loop (residues 131-151 in a lipase (FClip1 from thermophilic bacterium Fervidobacterium changbaicum by loop deletion, alanine-scanning mutagenesis and site-directed mutagenesis. We found that the upper part of the NC-loop (residues 131-138 was of great importance to enzyme catalysis. Single substitutions in this region could fine-tune the activity of FClip1 as much as 41-fold, and any deletions from this region rendered the enzyme completely inactive. The lower part of the NC-loop (residues 139-151 was capable of enduring extensive deletions without loss of activity. The shortened mutants in this region were found to show both improved activity and increased stability simultaneously. We therefore speculated that the NC-loop, especially the lower part, would be a perfect target for enzyme engineering to optimize the enzymatic properties, and might present a hot zone for the divergent evolution of α/β hydrolases. Our findings may provide an opportunity for better understanding of the mechanism of divergent evolution in the α/β hydrolase fold superfamily, and may also guide the design of novel biocatalysts for industrial applications.
Buras, Andrzej J; Lautenbacher, M E; Buras, Andrzej J.; Jamin, Matthias; Lautenbacher, Markus E.
1993-01-01
We calculate the $10\\times 10$ two--loop anomalous dimension matrix to order $\\ord(\\alpha_e \\alpha_s)$ in the dimensional regularization scheme with anticommuting $\\gamma_5$ (NDR) which is necessary for the extension of the $\\Delta S=1$ weak Hamiltonian involving electroweak penguins beyond the leading logarithmic approximation. We demonstrate, how a direct calculation of penguin diagrams involving $\\gamma_5$ in closed fermion loops can be avoided thus allowing a consistent calculation of two--loop anomalous dimensions in the simplest renormalization scheme with anticommuting $\\gamma_5$ in $D$ dimensions. We give the necessary one--loop finite terms which allow to obtain the corresponding two--loop anomalous dimension matrix in the HV scheme with non--anticommuting $\\gamma_5$.
Temporary umbilical loop colostomy for anorectal malformations.
Hamada, Yoshinori; Takada, Kohei; Nakamura, Yusuke; Sato, Masahito; Kwon, A-Hon
2012-11-01
Transumbilical surgical procedures have been reported to be a feasible, safe, and cosmetically excellent procedure for various pediatric surgical diseases. Umbilical loop colostomies have previously been created in patients with Hirschsprung's disease, but not in patients with anorectal malformations (ARMs). We assessed the feasibility and cosmetic results of temporal umbilical loop colostomy (TULC) in patients with ARMs. A circumferential skin incision was made at the base of the umbilical cord under general anesthesia. The skin, subcutaneous tissue, and fascia were cored out vertically, and the umbilical vessels and urachal remnant were individually ligated apart from the opening in the fascia. A loop colostomy was created in double-barreled fashion with a high chimney more than 2 cm above the level of the skin. The final size of the opening in the skin and fascia was modified according to the size of the bowel. The bowel wall was fixed separately to the peritoneum and fascia with interrupted 5-0 absorbable sutures. The bowel was opened longitudinally and everted without suturing to the skin. The loop was divided 7 days postoperatively, and diversion of the oral bowel was completed. The colostomy was closed 2-3 months after posterior saggital anorectoplasty through a peristomal skin incision followed by end-to-end anastomosis. Final wound closure was performed in a semi-opened fashion to create a deep umbilicus. TULCs were successfully created in seven infants with rectourethral bulbar fistula or rectovestibular fistula. Postoperative complications included mucosal prolapse in one case. No wound infection or spontaneous umbilical ring narrowing was observed. Skin problems were minimal, and stoma care could easily be performed by attaching stoma bag. Healing of umbilical wounds after TULC closure was excellent. The umbilicus may be an alternative stoma site for temporary loop colostomy in infants with intermediate-type anorectal malformations, who undergo radical
The four-loop six-gluon NMHV ratio function
Dixon, Lance J. [SLAC National Accelerator Lab., Stanford, CA (United States); California Inst. of Technology (CalTech), Pasadena, CA (United States); von Hippel, Matt [Perimeter Inst. for Theoretical Physics, Waterloo, ON (Canada); McLeod, Andrew J. [SLAC National Accelerator Lab., Stanford, CA (United States)
2016-01-11
We use the hexagon function bootstrap to compute the ratio function which characterizes the next-to-maximally-helicity-violating (NMHV) six-point amplitude in planar N = 4 super-Yang-Mills theory at four loops. A powerful constraint comes from dual superconformal invariance, in the form of a Q^{-} differential equation, which heavily constrains the first derivatives of the transcendental functions entering the ratio function. At four loops, it leaves only a 34-parameter space of functions. Constraints from the collinear limits, and from the multi-Regge limit at the leading-logarithmic (LL) and next-to-leading-logarithmic (NLL) order, suffice to fix these parameters and obtain a unique result. We test the result against multi- Regge predictions at NNLL and N^{3}LL, and against predictions from the operator product expansion involving one and two flux-tube excitations; all cross-checks are satisfied. We also study the analytical and numerical behavior of the parity-even and parity-odd parts on various lines and surfaces traversing the three-dimensional space of cross ratios. As part of this program, we characterize all irreducible hexagon functions through weight eight in terms of their coproduct. Furthermore, we provide representations of the ratio function in particular kinematic regions in terms of multiple polylogarithms.
Modeling of hysteresis loops by Monte Carlo simulation
Z. Nehme
2015-12-01
Full Text Available Recent advances in MC simulations of magnetic properties are rather devoted to non-interacting systems or ultrafast phenomena, while the modeling of quasi-static hysteresis loops of an assembly of spins with strong internal exchange interactions remains limited to specific cases. In the case of any assembly of magnetic moments, we propose MC simulations on the basis of a three dimensional classical Heisenberg model applied to an isolated magnetic slab involving first nearest neighbors exchange interactions and uniaxial anisotropy. Three different algorithms were successively implemented in order to simulate hysteresis loops: the classical free algorithm, the cone algorithm and a mixed one consisting of adding some global rotations. We focus particularly our study on the impact of varying the anisotropic constant parameter on the coercive field for different temperatures and algorithms. A study of the angular acceptation move distribution allows the dynamics of our simulations to be characterized. The results reveal that the coercive field is linearly related to the anisotropy providing that the algorithm and the numeric conditions are carefully chosen. In a general tendency, it is found that the efficiency of the simulation can be greatly enhanced by using the mixed algorithm that mimic the physics of collective behavior. Consequently, this study lead as to better quantified coercive fields measurements resulting from physical phenomena of complex magnetic (nanoarchitectures with different anisotropy contributions.
Modeling of hysteresis loops by Monte Carlo simulation
Nehme, Z.; Labaye, Y.; Sayed Hassan, R.; Yaacoub, N.; Greneche, J. M.
2015-12-01
Recent advances in MC simulations of magnetic properties are rather devoted to non-interacting systems or ultrafast phenomena, while the modeling of quasi-static hysteresis loops of an assembly of spins with strong internal exchange interactions remains limited to specific cases. In the case of any assembly of magnetic moments, we propose MC simulations on the basis of a three dimensional classical Heisenberg model applied to an isolated magnetic slab involving first nearest neighbors exchange interactions and uniaxial anisotropy. Three different algorithms were successively implemented in order to simulate hysteresis loops: the classical free algorithm, the cone algorithm and a mixed one consisting of adding some global rotations. We focus particularly our study on the impact of varying the anisotropic constant parameter on the coercive field for different temperatures and algorithms. A study of the angular acceptation move distribution allows the dynamics of our simulations to be characterized. The results reveal that the coercive field is linearly related to the anisotropy providing that the algorithm and the numeric conditions are carefully chosen. In a general tendency, it is found that the efficiency of the simulation can be greatly enhanced by using the mixed algorithm that mimic the physics of collective behavior. Consequently, this study lead as to better quantified coercive fields measurements resulting from physical phenomena of complex magnetic (nano)architectures with different anisotropy contributions.
The four-loop six-gluon NMHV ratio function
Dixon, Lance J; McLeod, Andrew J
2015-01-01
We use the hexagon function bootstrap to compute the ratio function which characterizes the next-to-maximally-helicity-violating (NMHV) six-point amplitude in planar $\\mathcal{N} = 4$ super-Yang-Mills theory at four loops. A powerful constraint comes from dual superconformal invariance, in the form of a $\\bar{Q}$ differential equation, which heavily constrains the first derivatives of the transcendental functions entering the ratio function. At four loops, it leaves only a 34-parameter space of functions. Constraints from the collinear limits, and from the multi-Regge limit at the leading-logarithmic (LL) and next-to-leading-logarithmic (NLL) order, suffice to fix these parameters and obtain a unique result. We test the result against multi-Regge predictions at NNLL and N$^3$LL, and against predictions from the operator product expansion involving one and two flux-tube excitations; all cross-checks are satisfied. We study the analytical and numerical behavior of the parity-even and parity-odd parts on various...
Closed Loop Finite Element Modeling of Piezoelectric Smart Structures
Guang Meng
2006-01-01
Full Text Available The objective of this paper is to develop a general design and analysis scheme for actively controlled piezoelectric smart structures. The scheme involves dynamic modeling of a smart structure, designing control laws and closed-loop simulation in a finite element environment. Based on the structure responses determined by finite element method, a modern system identification technique known as Observer/Kalman filter Identification (OKID technique is used to determine the system Markov parameters. The Eigensystem Realization Algorithm (ERA is then employed to develop an explicit state space model of the equivalent linear system for control law design. The Linear Quadratic Gaussian (LQG control law design technique is employed to design a control law. By using ANSYS parametric design language (APDL, the control law is incorporated into the ANSYS finite element model to perform closed loop simulations. Therefore, the control law performance can be evaluated in the context of a finite element environment. Finally, numerical examples have demonstrated the validity and efficiency of the proposed design scheme. Without any further modifications, the design scheme can be readily applied to other complex smart structures.
Pathogenesis of mucosal injury in the blind loop syndrome.
Jonas, A; Krishnan, C; Forstner, G
1978-11-01
Bacterial extracts were prepared from cultures originating in chronic self-filling intestinal blind loops in rats. Their ability to remove active maltase molecules from isolated brush border membranes was studied in vitro. Twelve strains in 51 tested, belonging to one of three species, Bacteroides fragilis, Clostridium perfringens, and Streptococcus fecalis, possessed maltase-releasing activity. The ability to remove maltase correlated well with the ability to hydrolyze p-nitrophenyl-tert-butyloxycarbonyl-l-alaninate (NBA), an ester substrate rapidly hydrolyzed by elastase, but not with substrated favored by tryhsin and chymotrypsin. Maltase-releasing activity from C. perfringens was strongly inhibited by soybean trypsin inhibitor and to a lesser extent by lima bean trypsin inhibitor. Of four chloromethylketone active-site directed inhibitors tested with specificities for elastase, trypsin, and chymotrypsin, inhibition was maximal with elastase-specific inhibitors. In two species, activity was shown to be heat sensitive, and to be inhibited by concentration of the extract. In one species maltase-releasing activity was shown to be due to an enzyme of molecular weight at least 66,000 with the capacity to remove lactase, sucrase, and alkaline phosphatase, as well as maltase. The results indicate that anaerobic or facultatively anaerobic species, previously identified with the pathology of of the blind loop syndrome, contain proteases which are capable of removing components of the intestinal surface membrane. These proteases appear to have elastase-like substrate specificity and may be involved in the etiology of disaccharidase deficiency in bacterial overgrowth syndromes.
An holomorphic study of the Smarandache concept in loops
Jaiyeola, Temitope Gbolahan
2006-01-01
If two loops are isomorphic, then it is shown that their holomorphs are also isomorphic. Conversely, it is shown that if their holomorphs are isomorphic, then the loops are isotopic. It is shown that a loop is a Smarandache loop if and only if its holomorph is a Smarandache loop. This statement is also shown to be true for some weak Smarandache loops(inverse property, weak inverse property) but false for others(conjugacy closed, Bol, central, extra, Burn, A-, homogeneous) except if their holomorphs are nuclear or central. A necessary and sufficient condition for the Nuclear-holomorph of a Smarandache Bol loop to be a Smarandache Bruck loop is shown. Whence, it is found also to be a Smarandache Kikkawa loop if in addition the loop is a Smarandache A-loop with a centrum holomorph. Under this same necessary and sufficient condition, the Central-holomorph of a Smarandache A-loop is shown to be a Smarandache K-loop.
Three-loop QED vacuum polarization and the four-loop muon anomalous magnetic moment
Baikov, P A
1995-01-01
Three--loop contributions to massive QED vacuum polarization are evaluated by a combination of analytical and numerical techniques. The first three Taylor coefficients, at small q^2, are obtained analytically, using d\\/--dimensional recurrence relations. Combining these with analytical input at threshold, and at large q^2, an accurate Pad\\'e approximation is obtained, for all q^2. Inserting this in the one--loop diagram for the muon anomalous magnetic moment, we find reasonable agreement with four--loop, single--electron--loop, muon--anomaly contributions, recently re--evaluated by Kinoshita, using 8--dimensional Monte--Carlo integration. We believe that our new method is at least two orders of magnitude more accurate than the Monte--Carlo approach, whose uncertainties appear to have been underestimated, by a factor of 6.
Extending the Universal One-Loop Effective Action: heavy-light coefficients
Ellis, Sebastian A. R.; Quevillon, Jérémie; You, Tevong; Zhang, Zhengkang
2017-08-01
The Universal One-Loop Effective Action (UOLEA) is a general expression for the effective action obtained by evaluating in a model-independent way the one-loop expansion of a functional path integral. It can be used to match UV theories to their low-energy EFTs more efficiently by avoiding redundant steps in the application of functional methods, simplifying the process of obtaining Wilson coefficients of operators up to dimension six. In addition to loops involving only heavy fields, matching may require the inclusion of loops containing both heavy and light particles. Here we use the recently-developed covariant diagram technique to extend the UOLEA to include heavy-light terms which retain the same universal structure as the previously-derived heavy-only terms. As an example of its application, we integrate out a heavy singlet scalar with a linear coupling to a light doublet Higgs. The extension presented here is a first step towards completing the UOLEA to incorporate all possible structures encountered in a covariant derivative expansion of the one-loop path integral.
The complete two-loop integrated jet thrust distribution in soft-collinear effective theory
von Manteuffel, Andreas; Schabinger, Robert M.; Zhu, Hua Xing
2014-03-01
In this work, we complete the calculation of the soft part of the two-loop integrated jet thrust distribution in e+e- annihilation. This jet mass observable is based on the thrust cone jet algorithm, which involves a veto scale for out-of-jet radiation. The previously uncomputed part of our result depends in a complicated way on the jet cone size, r, and at intermediate stages of the calculation we actually encounter a new class of multiple polylogarithms. We employ an extension of the coproduct calculus to systematically exploit functional relations and represent our results concisely. In contrast to the individual contributions, the sum of all global terms can be expressed in terms of classical polylogarithms. Our explicit two-loop calculation enables us to clarify the small r picture discussed in earlier work. In particular, we show that the resummation of the logarithms of r that appear in the previously uncomputed part of the two-loop integrated jet thrust distribution is inextricably linked to the resummation of the non-global logarithms. Furthermore, we find that the logarithms of r which cannot be absorbed into the non-global logarithms in the way advocated in earlier work have coefficients fixed by the two-loop cusp anomalous dimension. We also show that in many cases one can straightforwardly predict potentially large logarithmic contributions to the integrated jet thrust distribution at L loops by making use of analogous contributions to the simpler integrated hemisphere soft function.
From Multileg Loops to Trees (by-passing Feynman's Tree Theorem)
Rodrigo, German; /Valencia U., IFIC; Catani, Stefano; /INFN, Florence /Florence U.; Gleisberg, Tanju; /SLAC; Krauss, Frank; /Durham U., IPPP; Winter, Jan-Christopher; /Fermilab
2011-10-14
We illustrate a duality relation between one-loop integrals and single-cut phase-space integrals. The duality relation is realised by a modification of the customary +i0 prescription of the Feynman propagators. The new prescription regularizing the propagators, which we write in a Lorentz covariant form, compensates for the absence of multiple-cut contributions that appear in the Feynman Tree Theorem. The duality relation can be extended to generic one-loop quantities, such as Green's functions, in any relativistic, local and unitary field theories. The physics program of LHC requires the evaluation of multi-leg signal and background processes at next-to-leading order (NLO). In the recent years, important efforts have been devoted to the calculation of many 2 {yields} 3 processes and some 2 {yields} 4 processes. We have recently proposed a method to compute multi-leg one-loop cross sections in perturbative field theories. The method uses combined analytical and numerical techniques. The starting point of the method is a duality relation between one-loop integrals and phase-space integrals. In this respect, the duality relation has analogies with the Feynman's Tree Theorem (FTT). The key difference with the FTT is that the duality relation involves only single cuts of the one-loop Feynman diagrams. In this talk, we illustrate the duality relation, and discuss its correspondence, similarities, and differences with the FTT.
Solving differential equations for 3-loop diagrams relation to hyperbolic geometry and knot theory
Broadhurst, D J
1998-01-01
In hep-th/9805025, a result for the symmetric 3-loop massive tetrahedron in 3 dimensions was found, using the lattice algorithm PSLQ. Here we give a more general formula, involving 3 distinct masses. A proof is devised, though it cannot be accounted as a derivation; rather it certifies that an Ansatz found by PSLQ satisfies a more easily derived pair of partial differential equations. The result is similar to Schläfli's formula for the volume of a bi-rectangular hyperbolic tetrahedron, revealing a novel connection between 3-loop diagrams and 1-loop boxes. We show that each reduces to a common basis: volumes of ideal tetrahedra, corresponding to 1-loop massless triangle diagrams. Ideal tetrahedra are also obtained when evaluating the volume complementary to a hyperbolic knot. In the case that the knot is positive, and hence implicated in field theory, ease of ideal reduction correlates with likely appearance in counterterms. Volumes of knots relevant to the number content of multi-loop diagrams are evaluated;...
Loop diuretics have anxiolytic effects in rat models of conditioned anxiety.
Andrew D Krystal
Full Text Available A number of antiepileptic medications that modulate GABA(A mediated synaptic transmission are anxiolytic. The loop diuretics furosemide (Lasix and bumetanide (Bumex are thought to have antiepileptic properties. These drugs also modulate GABA(A mediated signalling through their antagonism of cation-chloride cotransporters. Given that loop diuretics may act as antiepileptic drugs that modulate GABAergic signalling, we sought to investigate whether they also mediate anxiolytic effects. Here we report the first investigation of the anxiolytic effects of these drugs in rat models of anxiety. Furosemide and bumetanide were tested in adult rats for their anxiolytic effects using four standard anxiety models: 1 contextual fear conditioning; 2 fear-potentiated startle; 3 elevated plus maze, and 4 open-field test. Furosemide and bumetanide significantly reduced conditioned anxiety in the contextual fear-conditioning and fear-potentiated startle models. At the tested doses, neither compound had significant anxiolytic effects on unconditioned anxiety in the elevated plus maze and open-field test models. These observations suggest that loop diuretics elicit significant anxiolytic effects in rat models of conditioned anxiety. Since loop diuretics are antagonists of the NKCC1 and KCC2 cotransporters, these results implicate the cation-chloride cotransport system as possible molecular mechanism involved in anxiety, and as novel pharmacological target for the development of anxiolytics. In view of these findings, and since furosemide and bumetanide are safe and well tolerated drugs, the clinical potential of loop diuretics for treating some types of anxiety disorders deserves further investigation.
Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety
Krystal, Andrew D.; Sutherland, Janice; Hochman, Daryl W.
2012-01-01
A number of antiepileptic medications that modulate GABAA mediated synaptic transmission are anxiolytic. The loop diuretics furosemide (Lasix) and bumetanide (Bumex) are thought to have antiepileptic properties. These drugs also modulate GABAA mediated signalling through their antagonism of cation-chloride cotransporters. Given that loop diuretics may act as antiepileptic drugs that modulate GABAergic signalling, we sought to investigate whether they also mediate anxiolytic effects. Here we report the first investigation of the anxiolytic effects of these drugs in rat models of anxiety. Furosemide and bumetanide were tested in adult rats for their anxiolytic effects using four standard anxiety models: 1) contextual fear conditioning; 2) fear-potentiated startle; 3) elevated plus maze, and 4) open-field test. Furosemide and bumetanide significantly reduced conditioned anxiety in the contextual fear-conditioning and fear-potentiated startle models. At the tested doses, neither compound had significant anxiolytic effects on unconditioned anxiety in the elevated plus maze and open-field test models. These observations suggest that loop diuretics elicit significant anxiolytic effects in rat models of conditioned anxiety. Since loop diuretics are antagonists of the NKCC1 and KCC2 cotransporters, these results implicate the cation-chloride cotransport system as possible molecular mechanism involved in anxiety, and as novel pharmacological target for the development of anxiolytics. In view of these findings, and since furosemide and bumetanide are safe and well tolerated drugs, the clinical potential of loop diuretics for treating some types of anxiety disorders deserves further investigation. PMID:22514741
Closed-loop neuronal computations: focus on vibrissa somatosensation in rat.
Ahissar, Ehud; Kleinfeld, David
2003-01-01
Two classes of neuronal architectures dominate in the ongoing debate on the nature of computing by nervous systems. The first is a predominantly feedforward architecture, in which local interactions among neurons within each processing stage play a less influential role compared with the drive of the input to that stage. The second class is a recurrent network architecture, in which the local interactions among neighboring neurons dominate the dynamics of neuronal activity so that the input acts only to bias or seed the state of the network. The study of sensorimotor networks, however, serves to highlight a third class of architectures, which is neither feedforward nor locally recurrent and where computations depend on large-scale feedback loops. Findings that have emerged from our laboratories and those of our colleagues suggest that the vibrissa sensorimotor system is involved in such closed-loop computations. In particular, single unit responses from vibrissa sensory and motor areas show generic signatures of phase-sensitive detection and control at the level of thalamocortical and corticocortical loops. These loops are likely to be components within a greater closed-loop vibrissa sensorimotor system, which optimizes sensory processing.
A kissing loop is important for btuB riboswitch ligand sensing and regulatory control.
Lussier, Antony; Bastet, Laurène; Chauvier, Adrien; Lafontaine, Daniel A
2015-10-30
RNA-based genetic regulation is exemplified by metabolite-binding riboswitches that modulate gene expression through conformational changes. Crystal structures show that the Escherichia coli btuB riboswitch contains a kissing loop interaction that is in close proximity to the bound ligand. To analyze the role of the kissing loop interaction in the riboswitch regulatory mechanism, we used RNase H cleavage assays to probe the structure of nascent riboswitch transcripts produced by the E. coli RNA polymerase. By monitoring the folding of the aptamer, kissing loop, and riboswitch expression platform, we established the conformation of each structural component in the absence or presence of bound adenosylcobalamin. We found that the kissing loop interaction is not essential for ligand binding. However, we showed that kissing loop formation improves ligand binding efficiency and is required to couple ligand binding to the riboswitch conformational changes involved in regulating gene expression. These results support a mechanism by which the btuB riboswitch modulates the formation of a tertiary structure to perform metabolite sensing and regulate gene expression. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
A Kissing Loop Is Important for btuB Riboswitch Ligand Sensing and Regulatory Control*
Lussier, Antony; Bastet, Laurène; Chauvier, Adrien; Lafontaine, Daniel A.
2015-01-01
RNA-based genetic regulation is exemplified by metabolite-binding riboswitches that modulate gene expression through conformational changes. Crystal structures show that the Escherichia coli btuB riboswitch contains a kissing loop interaction that is in close proximity to the bound ligand. To analyze the role of the kissing loop interaction in the riboswitch regulatory mechanism, we used RNase H cleavage assays to probe the structure of nascent riboswitch transcripts produced by the E. coli RNA polymerase. By monitoring the folding of the aptamer, kissing loop, and riboswitch expression platform, we established the conformation of each structural component in the absence or presence of bound adenosylcobalamin. We found that the kissing loop interaction is not essential for ligand binding. However, we showed that kissing loop formation improves ligand binding efficiency and is required to couple ligand binding to the riboswitch conformational changes involved in regulating gene expression. These results support a mechanism by which the btuB riboswitch modulates the formation of a tertiary structure to perform metabolite sensing and regulate gene expression. PMID:26370077
Yamanaka, Nodoka
2012-01-01
We evaluate the Barr-Zee type two-loop level contribution to the fermion electric and chromo-electric dipole moments with sfermion loop in R-parity violating supersymmetric models. It is found that the Barr-Zee type fermion dipole moment with sfermion loop acts destructively to the currently known fermion loop contribution, and that it has small effect when the mass of squarks or charged sleptons in the loop is larger than or comparable to that of the sneutrinos, but cannot be neglected if the sneutrinos are much heavier than loop sfermions.
Comparison of Single Loop and Dual Loop PP Reactors and PP Product Development
Lu Yunfeng; Jiang Rong; Feng Suogui
2003-01-01
The present status of PP technology in China is presented. Through a review of single loop and dual loop PP reactor technology as well as development and utilization of PP products it is concluded that import of PP technology should be based on the demand of PP products and market trend with consideration of local conditions. The existing problems and future development of PP technology in China are discussed.
Bilal, Adel
2014-01-01
We study two-dimensional quantum gravity on arbitrary genus Riemann surfaces in the Kaehler formalism where the basic quantum field is the (Laplacian of the) Kaehler potential. We do a careful first-principles computation of the fixed-area partition function $Z[A]$ up to and including all two-loop contributions. This includes genuine two-loop diagrams as determined by the Liouville action, one-loop diagrams resulting from the non-trivial measure on the space of metrics, as well as one-loop diagrams involving various counterterm vertices. Contrary to what is often believed, several such counterterms, in addition to the usual cosmological constant, do and must occur. We consistently determine the relevant counterterms from a one-loop computation of the full two-point Green's function of the Kaehler field. Throughout this paper we use the general spectral cutoff regularization developed recently and which is well-suited for multi-loop computations on curved manifolds. At two loops, while all "unwanted" contribut...
Gao, Yanfei; Larson, Bennett C.
2015-10-01
There are large classes of materials problems that involve the solutions of stress, displacement, and strain energy of dislocation loops in elastically anisotropic solids, including increasingly detailed investigations of the generation and evolution of irradiation induced defect clusters ranging in sizes from the micro- to meso-scopic length scales. Based on a two-dimensional Fourier transform and Stroh formalism that are ideal for homogeneous and layered anisotropic solids, we have developed robust and computationally efficient methods to calculate the displacement fields for circular and polygonal dislocation loops. Using the homogeneous nature of the Green tensor of order -1, we have shown that the displacement and stress fields of dislocation loops can be obtained by numerical quadrature of a line integral. In addition, it is shown that the sextuple integrals associated with the strain energy of loops can be represented by the product of a pre-factor containing elastic anisotropy effects and a universal term that is singular and equal to that for elastic isotropic case. Furthermore, we have found that the self-energy pre-factor of prismatic loops is identical to the effective modulus of normal contact, and the pre-factor of shear loops differs from the effective indentation modulus in shear by only a few percent. These results provide a convenient method for examining dislocation reaction energetic and efficient procedures for numerical computation of local displacements and stresses of dislocation loops, both of which play integral roles in quantitative defect analyses within combined experimental-theoretical investigations.
Scattering Amplitudes/Wilson Loop Duality In ABJM Theory
Bianchi, Marco S; Mauri, Andrea; Penati, Silvia; Santambrogio, Alberto
2011-01-01
For N=6 superconformal Chern-Simons-matter theories in three dimensions, by a direct superspace Feynman diagram approach, we compute the two-loop four-point scatteringa amplitude with external chiral matter fields. We find that the result is in perfect agreement with the two-loop result for a light-like four-polygon Wilson loop. This is a nontrivial evidence of the scattering amplitudes/Wilson loop duality in three dimensions. Moreover, both the IR divergent and the finite parts of our two-loop result agree with a BDS-like ansatz for all-loop amplitudes where the scaling function is given in terms of the N=4 SYM one, according to the conjectured Bethe equations for ABJM. Consequently, we are able to make a prediction for the four-loop correction to the amplitude. We also discuss the dual conformal invariance of the two-loop result.
Effective potential for Polyakov loops in lattice QCD
Nemoto, Y.; RBC Collaboration
2003-05-01
Toward the derivation of an effective theory for Polyakov loops in lattice QCD, we examine Polyakov loop correlation functions using the multi-level algorithm which was recently developed by Luscher and Weisz.
Gravitational back reaction on piecewise linear cosmic string loops
Wachter, Jeremy M
2016-01-01
We calculate the metric and affine connection due to a piecewise linear cosmic string loop, and the effect of gravitational back reaction for the Garfinkle-Vachaspati loop with four straight segments. As expected, back reaction reduces the size of the loop, in accord with the energy going into gravitational waves. The "square" loop whose generators lie at right angles evaporates without changing shape, but in all other cases, the kinks become less sharp and segments between kinks become curved. If the loop is close to the square case, the loop will evaporate before its kinks are significantly changed; if it is far from square, the opening out of the kinks is much faster than evaporation of the loop. In more realistic loops, the curvature of the straight segments due to gravitational back reaction may lead to cusps which did not exist in the original shape with the bending of the string concentrated at kinks.
Vapor Compressor Driven Hybrid Two-Phase Loop Project
National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will demonstrate a vapor compressor driven hybrid two-phase loop technology. The hybrid two-phase loop...
A two-loop excitation control system for synchronous generators
Alvarez-Ramirez, Jose; Cervantes, Ilse; Escarela-Perez, Rafael; Espinosa-Perez, Gerardo [Seccion de Estudios de Posgrado e Investigacion ESIME-C, Av. Santa Ana 1000 Col. San Francisco Culhuacan, Mexico D.F. 04430 (Mexico)
2005-10-01
An excitation controller for a single generator based on modern multi-loop design methodology is presented in this paper. The proposed controller consists of two-loops: a stabilizing (damping injection) loop and a voltage regulating loop. The task of the stabilizing loop is to add damping in the face of voltage oscillations. The voltage regulating loop is basically a PI compensator whose objective is to obtain terminal voltage regulation about the prescribed reference. The main contribution of this paper is to give some insights into the systematic derivation of multi-loop controllers of power generators. Certain connections between the two-loop excitation controller and standard PSS-AVR schemes are discussed. In this way, some insight into the stability of the standard PSS scheme is obtained from the analysis of the proposed controller. The proposed controller is evaluated via numerical simulations on a full finite-element model. (author)
Chimera: A hybrid approach to numerical loop quantum cosmology
Diener, Peter; Singh, Parampreet
2013-01-01
The existence of a quantum bounce in isotropic spacetimes is a key result in loop quantum cosmology (LQC), which has been demonstrated to arise in all the models studied so far. In most of the models, the bounce has been studied using numerical simulations involving states which are sharply peaked and which bounce at volumes much larger than the Planck volume. An important issue is to confirm the existence of the bounce for states which have a wide spread, or which bounce closer to the Planck volume. Numerical simulations with such states demand large computational domains, making them very expensive and practically infeasible with the techniques which have been implemented so far. To overcome these difficulties, we present an efficient hybrid numerical scheme using the property that at the small spacetime curvature, the quantum Hamiltonian constraint in LQC, which is a difference equation with uniform discretization in volume, can be approximated by a Wheeler-DeWitt differential equation. By carefully choosi...
Remarks on meson loop effects on quark models
Hammer, I K; Nefediev, A V
2016-01-01
We investigate the effect of meson loops on the spectrum of quark states. We demonstrate that in general quark states do not tend to get very broad if their coupling to the continuum increases, but instead they decouple from the latter in the large coupling limit. We ascribe this effect to the essentially nonperturbative unitarization procedure involved. In the meantime, some quark resonances behave very differently and demonstrate collectivity in the sense that their pole trajectories span a wide, as compared to the level spacing, region therefore acquiring contributions from multiple bare poles rather than from the closest neighbours. While the actual calculations are done within particular, very simplified models, it is argued that the findings might well be general.
Two-point functions in (loop) quantum cosmology
Calcagni, Gianluca; Gielen, Steffen; Oriti, Daniele, E-mail: calcagni@aei.mpg.de, E-mail: gielen@aei.mpg.de, E-mail: doriti@aei.mpg.de [Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Am Muehlenberg 1, D-14476 Golm (Germany)
2011-06-21
The path-integral formulation of quantum cosmology with a massless scalar field as a sum-over-histories of volume transitions is discussed, with particular but non-exclusive reference to loop quantum cosmology. Exploiting the analogy with the relativistic particle, we give a complete overview of the possible two-point functions, pointing out the choices involved in their definitions, deriving their vertex expansions and the composition laws they satisfy. We clarify the origin and relations of different quantities previously defined in the literature, in particular the tie between definitions using a group averaging procedure and those in a deparametrized framework. Finally, we draw some conclusions about the physics of a single quantum universe (where there exist superselection rules on positive- and negative-frequency sectors and different choices of inner product are physically equivalent) and multiverse field theories where the role of these sectors and the inner product are reinterpreted.
Two-point functions in (loop) quantum cosmology
Calcagni, Gianluca; Oriti, Daniele [Max-Planck-Institute for Gravitational Physics (Albert Einstein Institute), Am Muehlenberg 1, D-14476 Golm (Germany); Gielen, Steffen [Max-Planck-Institute for Gravitational Physics (Albert Einstein Institute), Am Muehlenberg 1, D-14476 Golm (Germany); DAMTP, Centre for Mathematical Sciences, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)
2011-07-01
We discuss the path-integral formulation of quantum cosmology with a massless scalar field as a sum-over-histories of volume transitions, with particular but non-exclusive reference to loop quantum cosmology (LQC). Exploiting the analogy with the relativistic particle, we give a complete overview of the possible two-point functions, pointing out the choices involved in their definitions, deriving their vertex expansions and the composition laws they satisfy. We clarify the origin and relations of different quantities previously defined in the literature, in particular the tie between definitions using a group averaging procedure and those in a deparametrized framework. Finally, we draw some conclusions about the physics of a single quantum universe (where there exist superselection rules on positive- and negative-frequency sectors and different choices of inner product are physically equivalent) and multiverse field theories where the role of these sectors and the inner product are reinterpreted.
Hanford Tank Farms Waste Certification Flow Loop Test Plan
Bamberger, Judith A.; Meyer, Perry A.; Scott, Paul A.; Adkins, Harold E.; Wells, Beric E.; Blanchard, Jeremy; Denslow, Kayte M.; Greenwood, Margaret S.; Morgen, Gerald P.; Burns, Carolyn A.; Bontha, Jagannadha R.
2010-01-01
A future requirement of Hanford Tank Farm operations will involve transfer of wastes from double shell tanks to the Waste Treatment Plant. As the U.S. Department of Energy contractor for Tank Farm Operations, Washington River Protection Solutions anticipates the need to certify that waste transfers comply with contractual requirements. This test plan describes the approach for evaluating several instruments that have potential to detect the onset of flow stratification and critical suspension velocity. The testing will be conducted in an existing pipe loop in Pacific Northwest National Laboratory’s facility that is being modified to accommodate the testing of instruments over a range of simulated waste properties and flow conditions. The testing phases, test matrix and types of simulants needed and the range of testing conditions required to evaluate the instruments are described
Remarks on meson loop effects on quark models
Hammer, I.K.; Hanhart, C. [Institut fuer Kernphysik and Juelich Center for Hadron Physics, Forschungszentrum Juelich, Institute for Advanced Simulation, Juelich (Germany); Nefediev, A.V. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); National Research Nuclear University MEPhI, Moscow (Russian Federation); Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region (Russian Federation)
2016-11-15
We investigate the effect of meson loops on the spectrum of quark states. We demonstrate that in general quark states do not tend to get very broad if their coupling to the continuum increases, but instead they decouple from the latter in the large coupling limit. We ascribe this effect to the essentially nonperturbative unitarization procedure involved. In the meantime, some quark resonances behave very differently and demonstrate collectivity in the sense that their pole trajectories span a wide, as compared to the level spacing, region therefore acquiring contributions from multiple bare poles rather than from the closest neighbors. While the actual calculations are done within particular, very simplified models, it is argued that the findings might well be general. (orig.)
Adaptive Simulated Annealing Based Protein Loop Modeling of Neurotoxins
陈杰; 黄丽娜; 彭志红
2003-01-01
A loop modeling method, adaptive simulated annealing, for ab initio prediction of protein loop structures, as an optimization problem of searching the global minimum of a given energy function, is proposed. An interface-friendly toolbox-LoopModeller in Windows and Linux systems, VC++ and OpenGL environments is developed for analysis and visualization. Simulation results of three short-chain neurotoxins modeled by LoopModeller show that the method proposed is fast and efficient.
An estimator-predictor approach to PLL loop filter design
Statman, Joseph I.; Hurd, William J.
1990-01-01
The design of digital phase locked loops (DPLL) using estimation theory concepts in the selection of a loop filter is presented. The key concept, that the DPLL closed-loop transfer function is decomposed into an estimator and a predictor, is discussed. The estimator provides recursive estimates of phase, frequency, and higher-order derivatives, and the predictor compensates for the transport lag inherent in the loop.
Peeters, M C; van Westen, G J P; Li, Q; IJzerman, A P
2011-01-01
G protein-coupled receptors (GPCRs) are the major drug target of medicines on the market today. Therefore, much research is and has been devoted to the elucidation of the function and three-dimensional structure of this large family of membrane proteins, which includes multiple conserved transmembrane domains connected by intra- and extracellular loops. In the last few years, the less conserved extracellular loops have garnered increasing interest, particularly after the publication of several GPCR crystal structures that clearly show the extracellular loops to be involved in ligand binding. This review will summarize the recent progress made in the clarification of the ligand binding and activation mechanism of class-A GPCRs and the role of extracellular loops in this process.