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Sample records for loft experiment lp-fp-2

  1. Sensitivity analysis for CORSOR models simulating fission product release in LOFT-LP-FP-2 severe accident experiment

    Energy Technology Data Exchange (ETDEWEB)

    Hoseyni, Seyed Mohsen [Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Dept. of Basic Sciences; Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Young Researchers and Elite Club; Pourgol-Mohammad, Mohammad [Sahand Univ. of Technology, Tabriz (Iran, Islamic Republic of). Dept. of Mechanical Engineering; Yousefpour, Faramarz [Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2017-03-15

    This paper deals with simulation, sensitivity and uncertainty analysis of LP-FP-2 experiment of LOFT test facility. The test facility simulates the major components and system response of a pressurized water reactor during a LOCA. MELCOR code is used for predicting the fission product release from the core fuel elements in LOFT LP-FP-2 experiment. Moreover, sensitivity and uncertainty analysis is performed for different CORSOR models simulating release of fission products in severe accident calculations for nuclear power plants. The calculated values for the fission product release are compared under different modeling options to the experimental data available from the experiment. In conclusion, the performance of 8 CORSOR modeling options is assessed for available modeling alternatives in the code structure.

  2. TRAC-PF1 code assessment using OECD LOFT LP-FP-1 experiment

    International Nuclear Information System (INIS)

    Barbero, F.J.

    1992-04-01

    This report assesses thermal-hydraulic aspects of LOFT LP-FP-1 experiment making use of TRAC-PF1/MOD1. LP-FP-1 experiment studies the system thermal-hydraulic and core thermal response for initial and boundary conditions similar to a large-break design basis LOCA leading to fission product release from the fuel cladding gap region. It also assesses the fission product retention effectiveness of the PWR-ECCS in best estimate conditions

  3. Code comparison results for the loft LP-FP-2 experiment

    International Nuclear Information System (INIS)

    Merilo, M.; Mecham, D.C.

    1991-01-01

    Computer code calculations are compared with thermal hydraulic and fission product release, transport, and deposition data obtained from the OECD-LOFT LP-FP-2 experiment. Except for the MAAP code, which is a fully integrated severe accident code, the thermalhydraulic and fission product behavior were calculated with different codes. Six organizations participated in the thermal hydraulic portion of the code comparison exercise. These calculations were performed with RELAP 5, SCDAP/RELAP 5, and MAAP. The comparisons show generally well developed capabilities to determine the thermal-hydraulic conditions during the early stages of a severe core damage accident. Four participants submitted detailed fission product behavior calculations. Except for MAAP, as stated previously, the fission product inventory, core damage, fission product release, transport and deposition were calculated independently with different codes. Much larger differences than observed for the thermalhydraulic comparison were evident. The fission product inventory calculations were generally in good agreement with each other. Large differences were observed for release fractions and amounts of deposition. Net release calculations from the primary system were generally accurate within a factor of two or three for the more important fission products

  4. Assessment of core damage models in SCDAP/RELAP5 during OECD LOFT LP-FP-2

    International Nuclear Information System (INIS)

    Coryell, E.W.

    1991-01-01

    The US Nuclear Regulatory Commission has sponsored a program to apply the SCDAP/RELAP5 code to analysis of the transient and reflood phases of the OECD LOFT LP-FP-2 Experiment. The principal objectives of the LP-FP-2 experiment were to determine the fission product release from the fuel during the early phases of a severe fuel damage scenario and to examine the phenomena controlling fission product transport in a vapor/aerosol environment. Calculations with the SCDAP/RELAP5 code, developed at the INEL with NRC support, have been performed to (1) examine the phenomena controlling the progression of both transient and reflood phases of the experiment, (2) enhance our understanding of the phenomena occurring during reflood and add credence to the postulated phenomenological sequence, (3) assess the ability of SCDAP/RELAP5 to examine severe fuel damage issues and phenomena, and (4) identify code strengths and deficiencies with the intent of prioritizing code improvements. Results indicate that the code is able to analyze the early phases of severe fuel damage reasonably well, with potential deficiencies in modelling interaction between molten control rod material and intact fuel

  5. Summary of important results and SCDAP/RELAP5 analysis for OECD LOFT experiment LP-FP-2

    International Nuclear Information System (INIS)

    Coryell, E.W.

    1994-04-01

    This report summarizes significant technical findings from the LP-FP-2 Experiment sponsored by OECD. It was the second, and final, fission product experiment conducted in the Loss-of-Fluid Test (LOFT) facility at the Idaho National Engineering Laboratory. The overall technical objective of the test was to contribute to the understanding of fuel rod behavior, hydrogen generation, and fission product release, transport, and deposition during a V-sequence accident scenario that resulted in severe core damage. An 11 by 11 test bundle, comprised of 100 pre-pressurized fuel rods, 11 control rods, and 10 instrumented guide tubes, was surrounded by an insulating shroud and contained in a specially designed central fuel module, that was inserted into the LOFT reactor. The simulated transient was a V-sequence loss-of-coolant accident scenario featuring a pipe break in the low pressure injection system line attached to the hot leg of the LOFT broken loop piping. The transient was terminated by reflood of the reactor vessel when the outer wall shroud temperature reached 1517 K. With sustained fission power and heat from oxidation and metal-water reactions, elevated temperatures resulted in zircaloy melting, fuel liquefaction, material relocation, and the release of hydrogen, aerosols, and fission products. A description and evaluation of the major phenomena, based upon the response of on line instrumentation, analysis of fission product data, post-irradiation examination of the fuel bundle, and calculations using the SCDAP/RELAP5 computer code, are presented

  6. Summary of important results and SCDAP/RELAP5 analysis for OECD LOFT experiment LP-FP-2

    Energy Technology Data Exchange (ETDEWEB)

    Coryell, E.W. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1994-04-01

    This report summarizes significant technical findings from the LP-FP-2 Experiment sponsored by the Organization of Economic Cooperation and Development (OECD). It was the second, and final, fission product experiment conducted in the Loss-of-Fluid Test (LOFT) facility at the Idaho National Engineering Laboratory. The overall technical objective of the test was to contribute to the understanding of fuel rod behavior, hydrogen generation, and fission product release, transport, and deposition during a V-sequence accident scenario that resulted in severe core damage. An 11 by 11 test bundle, comprised of 100 prepressurized fuel rods, 11 control rods, and 10 instrumented guide tubes, was surrounded by an insulating shroud and contained in a specially designed central fuel module, that was inserted into the LOFT reactor. The simulated transient was a V-sequence loss-of-coolant accident scenario featuring a pipe break in the low pressure injection system line attached to the hot leg of the LOFT broken loop piping. The transient was terminated by reflood of the reactor vessel when the outer wall shroud temperature reached 1517 K. With sustained fission power and heat from oxidation and metal-water reactions, elevated temperatures resulted in zircaloy melting, fuel liquefaction, material relocation, and the release of hydrogen, aerosols, and fission products. A description and evaluation of the major phenomena, based upon the response of on line instrumentation, analysis of fission product data, postirradiation examination of the fuel bundle, and calculations using the SCDAP/RELAP5 computer code, are presented.

  7. RELAP5/MOD2 post-test calculation of the OECD LOFT experiment LP-SB-2

    International Nuclear Information System (INIS)

    Perez, J.; Mendizabal, R.

    1992-04-01

    This document presents the analysis of the OECD LOFT LP-SB-2 Experiment performed by the Consejo de Seguridad Nuclear of Spain working group making use of RELAP5/MOD2 in the frame of the Spanish LOFT Project. LB-SB-2 experiment studies the effect of a delayed pump trip in a small break LOCA scenario with a 3-inch equivalent diameter break in the hot leg of a commercial PWR

  8. MELCOR 1.8.1 Assessment: LOFT integral experiment LP-FP-2

    International Nuclear Information System (INIS)

    Kmetyk, L.N.

    1992-12-01

    The MELCOR code has been used to model experiment LP-FP-2, an important source of integral data for qualifying severe accident code predictive capabilities. This assessment analysis clearly demonstrates MELCOR's ability to fulfill a large part of its primary, intended use, the calculation of severe accidents from full-power steady-state initiation through primary-system thermal/hydraulic response and core damage to fission product release, transport and deposition. After a number of code errors were identified and corrected, few nonstandard inputs and no code problem-specific modifications were needed to provide reasonable agreement with test data in all areas considered. Code-to-code comparisons show that MELCOR does at least as well as other ''best-estimate'' (i.e., SCDAP/RELAP5) or integral (i.e., MAAP) codes in predicting the thermal/hydraulic and core responses in this large-scale, integral experiment; in fact, MELCOR and MAAP appear to give the best agreement with data, especially for clad temperature histories. Further, our code-to-code comparisons indicate that MELCOR does at least as well as ''best-estimate'' fission product codes in predicting the source term, with a number of such codes having to be run in tandem and driven by test data or other ''best-estimate'' thermal/hydraulic and core damage codes to provide results equivalent to a single, integrated MELCOR calculation

  9. LOFT/LP-FP-1B, Loss of Fluid Test, Fission Product Release Experiment

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The seventh OECD LOFT experiment was conducted on 19 December 1984. It was the first of the two experiments to be performed in the LOFT facility with intentional release of fission products. Its objectives were to obtain data on fission product release from the fuel-cladding gap into vapor and reflood water and to collect data on transport of these fission products through and out of the reactor coolant system. The experiment was initiated by a reactor scram with one second delayed opening of the quick-opening blowdown valves. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  10. Postirradiation examination results from the LP-FP-2 center fuel module

    International Nuclear Information System (INIS)

    Jensen, S.M.; Akers, D.W.

    1990-01-01

    The LP-FP-2 experiment was conducted on July 9, 1985 in the Loss of Fluid Test (LOFT) facility located at the Idaho National Engineering Laboratory (INEL). The primary purpose of this experiment was to provide information of the release, transport, and deposition of fission products and aerosols during a sever core damage event performed in a large scale nuclear reactor facility. Postirradiation nondestructive and destructive examinations of the fuel bundle provided information to assist in achieving this objective, as well as providing information on the material behavior and interactions that occurred within the fuel bundle during this sever core damage experiment. This was a large-scale integral test, incorporating an 11 x 11 array of fuel rods, control rods, and instrumentation tubes, with an active core length of 1.68 m. Peak temperatures in the fuel bundle exceeded 2100 K or approximately 4.5 min, with localized peak temperatures exceeding the melting point of the UO 2 fuel (3120 K). Large amounts of zircaloy oxidation and material relocation occurred during the experiment. The transient phase was terminated by a rapid reflood of cooling water, which resulted in significant oxidation and hydrogen generation. Zircaloy oxidation during the reflood period caused a rapid temperature excursion to occur in the upper two-thirds of the fuel bundle. This article summarizes the data and analysis from the postirradiation examinations of the LP-FP-2 fuel bundle. 12 refs., 39 figs., 8 tabs

  11. LOFT/LP-FP-2, Loss of Fluid Test, Fission Product Release from Fuel

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The eighth OECD LOFT experiment was conducted on 7 March 1985. It was the second of the two experiments to be performed in the LOFT facility with intentional release of fission products. Its principal objectives were to determine the fission product release from the fuel during a severe fuel damage scenario and the subsequent transport of these fission products in a predominantly vapor/aerosol environment. This was the largest severe fuel damage experiment ever conducted, and serves as an important benchmark between smaller scale tests and the TMI-2 accident. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  12. LOFT/LP-LB-1, Loss of Fluid Test, Large-Break LOCA Experiment

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, Thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCE is expected to closely model a LPWR LOCA. 2 - Description of test: Experiment LP-LB-1 was conducted on 3 February 1984 in the Loss-of-Fluid Test (LOFT) facility at the Idaho National Engineering Laboratory under the auspices of the Organization for Economic Cooperation and Development. The primary objectives of Experiment LP-LB-1 were to determine system transient characteristics and to assess code predictive capabilities for design basis large-break loss-of-coolant accidents in pressurized water reactors (PWRs). This experiment simulated a double-ended offset shear of one inlet pipe in a four-loop PWR and was initiated from conditions representative of licensing limits in a PWR. Other boundary conditions for the simulation were loss of offsite power, rapid primary coolant pump coast down, and United Kingdom minimum safeguard emergency core coolant injection rates. The nuclear fuel rods were not pressurized. The transient was initiated by opening the quick-opening blowdown valves in the broken loop hot and cold legs. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  13. TRAC-PF1 MOD1 post test calculations of the OECD LOFT Experiment LP-SB-1

    International Nuclear Information System (INIS)

    Allen, E.J.

    1990-04-01

    Analysis of the small, hot leg break, OECD LOFT Experiment LP-SB-1. using the ''best-estimate'' computer code TRAC-PF1/MOD1 is presented. Descriptions of the LOFT facility and the LP-SB-1 experiment are given and development of the TRAC-PF1/MOD1 input model is detailed. The calculations performed in achieving the steady state conditions, from which the experiment was initiated, and the specification of experimental boundary conditions are outlined. 24 refs., 66 figs., 12 tabs

  14. LOFT/LP-02-6, Loss of Fluid Test, 1. OECD Large Break Experiment

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The fourth OECD LOFT experiment was conducted on 3 October 1983. This was the first OECD LOFT large break experiment. The initial and boundary conditions were chosen to be representative of USNRC licensing limits for commercial PWRs. This included loss of off-site power coincident with LOCA initiation. This experiment included the first use in LOFT of pressurized fuel rods in the center bundle. The experiment was initiated by opening the quick-opening blow-down valves in the broken hot and cold legs. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  15. RELAP5/MOD2 calculation of OECD LOFT test LP-FW-01

    International Nuclear Information System (INIS)

    Croxfod, M.G.; Harwood, C.; Hall, P.C.

    1992-04-01

    RELAP5/MOD2 is being used by GDCD for calculation of certain small break loss-of-coolant accidents and pressurized transients in the Sizewell ''B'' PWR. To test the ability of RELAP5/MOD2 to model the primary feed-and-bleed recovery procedure following a complete loss- of-feedwater event, post test calculations have been carried out of OECD LOFT test LP-FW-01. This report describes the comparison between the code calculations and the test data. It is found that although the standard version of RELAP5/MOD2 gives a reasonable prediction of the experimental transient, the long term pressure history is better calculated with a modified code version containing a revised horizontal stratification entrainment model. The latter allows an improved calculation of entrainment of liquid from the hot leg into the surge line. RELAP5/MOD2 is found to give a more accurate simulation of the experimental transient than was achieved in previous UK studies using RETRAN-02/MOD2

  16. LOFT/LP-SB-2, Loss of Fluid Test, Small Hot Leg Break LOCA, Delayed Pump

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The third OECD LOFT experiment was conducted on 14 July 1983. It simulated a 3-in (7.62 cm) equivalent break diameter located in the hot leg of the operating loop. The major objective of this experiment was to determine system transient characteristics for small hot leg break loss-of-coolant accidents with delayed pump trip. The experiment was conducted from initial temperature and pressure conditions representative of typical commercial PWRs. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  17. Best estimate prediction for LOFT nuclear experiment L3-2

    International Nuclear Information System (INIS)

    Kee, E.J.; Shinko, M.S.; Grush, W.H.; Condie, K.G.

    1980-02-01

    Comprehensive analyses using both the RELAP4 and the RELAP5 computer codes were performed to predict the LOFT transient thermal-hydraulic response for nuclear Loss-of-Coolant Experiment L3-2 to be performed in the Loss-of-Fluid Test (LOFT) facility. The LOFT experiment will simulate a small break in one of the cold legs of a large four-loop pressurized water reactor and will be conducted with the LOFT reactor operating at 50 MW. The break in LOCE L3-2 is sized to cause the break flow to be approximately equal to the high-pressure injection system flow at an intermediate pressure of approximately 7.6 MPa

  18. OECD-LOFT large break LOCA experiments: phenomenology and computer code analyses

    International Nuclear Information System (INIS)

    Brittain, I.; Aksan, S.N.

    1990-08-01

    Large break LOCA data from LOFT are a very important part of the world database. This paper describes the two double-ended cold leg break tests LP-02-6 and LP-LB-1 carried out within the OECD-LOFT Programme. Tests in LOFT were the first to show the importance of both bottom-up and top-down quenching during blowdown in removing stored energy from the fuel. These phenomena are discussed in detail, together with the related topics of the thermal performance of nuclear fuel and its simulation by electric fuel rod simulators, and the accuracy of cladding external thermocouples. The LOFT data are particularly important in the validation of integral thermal-hydraulics codes such as TRAC and RELAP5. Several OECD partner countries contributed analyses of the large break tests. Results of these analyses are summarised and some conclusions drawn. 32 figs., 3 tabs., 45 refs

  19. The LP-FP-2 severe fuel damage scenario and discussion of the relative influence of the transient and reflood phases in affecting the final condition of the bundle

    International Nuclear Information System (INIS)

    Modro, S.M.; Carboneau, M.L.

    1990-01-01

    The purpose of this paper is to review the evidence from the OECD LP-FP-2 experiment that a high temperature excursion occurred within the center fuel module (CFM) during the reflood portion of the test, was caused by rapid metal-water reaction. It is shown that this reflood scenario explains many perplexing observations from the experiment, in particular, the small amount of fission products and hydrogen transported to the blowdown suppression tank (BST) as compared with the larger quantities trapped within the primary coolant system (PCS). The timing and destruction of the CFM upper tie plate, as well as the transport of fuel debris to the top of this plate, are also explained. In general, all measurements, observations, and analyses of the LP-FP-2 data indicate that most of the CFM damage occurred during a relatively short period of time coincident with the reflood portion of the experiment. 4 refs., 6 figs

  20. LOFT/L2-3, Loss of Fluid Test, 2. NRC L2 Large Break LOCA Experiment

    International Nuclear Information System (INIS)

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This experiment was the second of the NRC L2 Series of nuclear large Break LOCA experiments, and was conducted on 12 May 1979. It simulated a 100% cold leg break with a maximum heat generation of 39 kW/m

  1. Experiment data report for LOFT large-break loss-of-coolant experiment L2-5

    International Nuclear Information System (INIS)

    Bayless, P.D.; Divine, J.M.

    1982-08-01

    Selected pertinent and uninterpreted data from the third nuclear large break loss-of-coolant experiment (Experiment L2-5) conducted in the Loss-of-Fluid Test (LOFT) facility are presented. The LOFT facility is a 50-MW(t) pressurized water reactor (PWR) system with instruments that measure and provide data on the system thermal-hydraulic and nuclear conditions. The operation of the LOFT system is typical of large [approx. 1000 MW(e)] commercial PWR operations. Experiment L2-5 simulated a double-ended offset shear of a cold leg in the primary coolant system. The primary coolant pumps were tripped within 1 s after the break initiation, simulating a loss of site power. Consistent with the loss of power, the starting of the high- and low-pressure injection systems was delayed. The peak fuel rod cladding temperature achieved was 1078 +- 13 K. The emergency core cooling system re-covered the core and quenched the cladding. No evidence of core damage was detected

  2. LOFT/LP-SB-1, Loss of Fluid Test, Small Hot Leg Break LOCA, Early Pump

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The second OECD LOFT experiment was conducted on 23 June 1983. It simulated a 3-in (7.62 cm) equivalent break diameter located in the hot leg of the operating loop. The major objective of this experiment was to determine system transient characteristics for small hot leg break loss-of-coolant accidents with early pump trip. The experiment was conducted from initial temperature and pressure conditions representative of typical commercial PWRs. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  3. LOFT/L2-5, Loss of Fluid Test, 3. NRC L2 Large Break LOCA Experiment

    International Nuclear Information System (INIS)

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This experiment was the third of the NRC L2 Series of nuclear large Break LOCA experiments, conducted on 16 June 1981. It simulated a 100% cold leg break with a maximum heat generation of 40 kW/m and rapid pump coast down

  4. Results of recent LOFT experiments

    International Nuclear Information System (INIS)

    Leach, L.P.; Hanson, D.J.; Batt, D.L.

    1982-01-01

    Five experiments were performed in the Loss-of-Fluid Test (LOFT) facility during the past year. The experiments conducted spanned a wide range of potential accident scenarios, including large and small break loss-of-coolant accidents (LOCAs), control rod withdrawal accidents, uncontrolled boron dilution, and anticipated transients without scram (ATWS). This summary describes these experiments and presents results available from the experiments and experiment prediction calculations. A brief overview is given for the remaining experiment planned in the LOFT Program

  5. LOFT/LP-FW-1, Loss of Fluid Test, PWR Response to Loss-of-Feedwater Transient

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The first OECD LOFT experiment was conducted on February 20, 1983. It was designed to evaluate the generic PWR system response during a complete loss-of-feedwater transient. The objective of the experiment was to investigate the performance of primary 'feed and bleed' using a 'bleed' from the PORV and 'feed' from the HPIS to provide decay heat removal and system pressure reduction while maintaining the primary coolant inventory. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  6. LOFT/LP-SB-3, Loss of Fluid Test, Cold Leg Break LOCA, No High Pressure injection System (HPIS)

    International Nuclear Information System (INIS)

    1989-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The sixth OECD LOFT experiment was conducted on 5 March 1984. It simulated a 1.8-in cold leg break LOCA with no HPIS available. This experiment was designed mainly for investigation of plant recovery effectiveness using secondary bleed and feed during core uncover and addressed accumulator injection at low pressure differentials. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

  7. LOFT instrumented fuel design and operating experience

    International Nuclear Information System (INIS)

    Russell, M.L.

    1979-01-01

    A summary description of the Loss-of-Fluid Test (LOFT) system instrumented core construction details and operating experience through reactor startup and loss-of-coolant experiment (LOCE) operations performed to date are discussed. The discussion includes details of the test instrumentation attachment to the fuel assembly, the structural response of the fuel modules to the forces generated by a double-ended break of a pressurized water reactor (PWR) coolant pipe at the inlet to the reactor vessel, the durability of the LOFT fuel and test instrumentation, and the plans for incorporation of improved fuel assembly test instrumentation features in the LOFT core

  8. Blowdown hydraulic influence on core thermal response in LOFT nuclear experiment L2-3

    International Nuclear Information System (INIS)

    Reeder, D.L.

    1979-01-01

    Experimental research into pressurized water reactor (PWR) loss-of-coolant phenomena conducted in the Loss-of-Fluid Test (LOFT) facility has given results indicating that for very large pipe breaks the core thermal response is tightly coupled to the fluid hydraulic phenomena during the blowdown phase of the loss-of-coolant transient. This summary presents and discusses data supporting this conclusion. LOFT Loss-of-Coolant Experiment (LOCE) L2-3 simulated a complete double-ended offset shear break of a primary coolant reactor vessel inlet pipe in a commercial PWR. The LOFT system conditions at experiment initiation were: fuel rod maximum linear heat generation rate (MLHGR) of 39.4 +- 3 kW/m, hot leg temperature of 593 +- 3 K, core ΔT of 32.2 +- 4 K, system pressure of 15.06 +- 0.03 MPa, and flow rate/system volume of 25.6 +- 0.8 kg/m 3 . These conditions are typical of those in commercial PWR systems at normal operating conditions

  9. PBF/LOFT Lead Rod Test Program experiment predictions document

    International Nuclear Information System (INIS)

    Varacalle, D.J.; Cox, W.R.; Niebruegge, D.A.; Seiber, S.J.; Brake, T.E.; Driskell, W.E.; Nigg, D.W.; Tolman, E.L.

    1978-12-01

    The PBF/LOFT Lead Rod (LLR) Test Program is being conducted to provide experimental information on the behavior of nuclear fuel under normal and accident conditions in the Power Burst Facility (PBF) at the Idaho National Engineering Laboratory. The PBF/LLR tests are designed to simulate the test conditions for the LOFT Power Ascension Tests L2-3 through L2-5. The test program has been designed to provide a parametric evaluation of the LOFT fuel (center and peripheral modules) over a wide range of power. This report presents the experiment predictions for the three four-rod LOCA tests

  10. Experiment prediction for Loft Nonnuclear Experiment L1-4

    International Nuclear Information System (INIS)

    White, J.R.; Berta, V.T.; Holmstrom, H.L.O.

    1977-04-01

    A computer analysis, using the WHAM and RELAP4 computer codes, was performed to predict the LOFT system thermal-hydraulic response for Experiment L1-4 of the nonnuclear (isothermal) test series. Experiment L1-4 will simulate a 200 percent double-ended offset shear in the cold leg of a four-loop large pressurized water reactor. A core simulator will be used to provide a reactor vessel pressure drop representative of the LOFT nuclear core. Experiment L1-4 will be initiated with a nominal isothermal primary coolant temperature of 282.2 0 C, a pressurizer pressure of 15.51 MPa, and a primary coolant flow of 270.9 kg/s. In general, the predictions of saturated blowdown for Experiment Ll-4 are consistent with the expected system behavior, and predicted trends agree with results from Semiscale Test S-01-4A, which simulated the Ll-4 experiment conditions

  11. Loft over ydelser

    DEFF Research Database (Denmark)

    Krogh Graversen, Brian; Tinggaard, Karen

    I de seneste år er der gennemført en række ændringer i reglerne for beregningen af den økonomiske hjælp til kontanthjælpsmodtagere for at øge disses økonomiske incitament til at finde et arbejde. En af ændringerne er indførelsen af et loft over, hvor meget kontanthjælpsmodtagerne samlet kan modtage...... desuden på, hvordan den økonomiske situation for de berørte familier har ændret sig. Endelig belyser de, hvilke udfordringer og problemer kommunerne har haft med implementeringen af lovgivningen vedrørende loft over ydelser. Undersøgelsen er bestilt og finansieret af Arbejdsdirektoratet....

  12. Experiment predictions of LOFT reflood behavior using the RELAP4/MOD6 code

    International Nuclear Information System (INIS)

    Lin, J.C.; Kee, E.J.; Grush, W.H.; White, J.R.

    1978-01-01

    The RELAP4/MOD6 computer code was used to predict the thermal-hydraulic transient for Loss-of-Fluid Test (LOFT) Loss-of-Coolant Accident (LOCA) experiments L2-2, L2-3, and L2-4. This analysis will aid in the development and assessment of analytical models used to analyze the LOCA performance of commercial power reactors. Prior to performing experiments in the LOFT facility, the experiments are modeled in counterpart tests performed in the nonnuclear Semiscale MOD 1 facility. A comparison of the analytical results with Semiscale data will verify the analytical capability of the RELAP4 code to predict the thermal-hydraulic behavior of the Semiscale LOFT counterpart tests. The analytical model and the results of analyses for the reflood portion of the LOFT LOCA experiments are described. These results are compared with the data from Semiscale

  13. Experiment prediction for LOFT nuclear experiments L5-1/L8-2

    International Nuclear Information System (INIS)

    Chen, T.H.; Modro, S.M.

    1982-01-01

    The LOFT Experiments L5-1 and L8-2 simulated intermediate break loss-of-coolant accidents with core uncovery. This paper compares the predictions with the measured data for these experiments. The RELAP5 code was used to perform best estimate double-blind and single-blind predictions. The double-blind calculations are performed prior to the experiment and use specified nominal initial and boundary conditions. The single-blind calculations are performed after the experiment and use measured initial and boundary conditions while maintaining all other parameters constant, including the code version. Comparisons of calculated results with experimental results are discussed; the possible causes of discrepancies are explored and explained. RELAP5 calculated system pressure, mass inventory, and fuel cladding temperature agree reasonably well with the experiment results, and only slight changes are noted between the double-blind and single-blind predictions

  14. Analysis of LOFT loss-of-coolant experiments L2-2, L2-3, and L3-0

    International Nuclear Information System (INIS)

    Leach, L.P.; Linebarger, J.H.

    1979-01-01

    A summary of results from Loss-of-Coolant Experiments (LOCE) L2-2, L2-3, and L3-0, conducted in the Loss-of-Fluid Test (LOFT) facility, and conclusions from posttest analyses of the experimental data are presented. LOCEs L2-2 and L2-3 were nuclear large break experiments and were dominated by a core-wide fuel rod cladding rewet, which limited the maximum fuel temperature. Analytical models only conservatively predicted the measured fuel rod temperatures and will require improvements to provide best estimate predictions in this area. Analysis of a large commercial pressurized water reactor (PWR) indicates that the cladding rewet observed in LOFT is also likely to occur in a large PWR, and that, therefore, safety analysis calculations of large loss-of-coolant accidents (LOCA) are more conservative than previously thought. LOCE L3-0 was an isothermal small break (top of pressurizer) experiment and illustrated that the pressurizer fills after the primary system fluid saturates someplace other than the pressurizer itself, that the indicated pressurizer level is higher than the actual level, and that additional model development and assessment work is necessary in order to predict small LOCAs as accurately as large LOCAs

  15. Experiment prediction for LOFT nuclear experiments L5-1 and L8-2

    International Nuclear Information System (INIS)

    Chen, T.H.; Modro, S.M.

    1983-01-01

    The LOFT Experiments L5-1 and L8-2 simulated intermediate break loss-of-coolant accidents with core uncovery. This paper compares the predictions with the measured data for these experiments. The RELAP5 code was used to perform best estimate double-blind and single-blind predictions. The double-blind calculations are performed prior to the experiment and use specified nominal initial and boundary conditions. The single-blind calculations are performed after the experiment and use measured initial and boundary conditions while maintaining all other parameters constant, including the code version. Comparisons of calculated results with experimental results are discussed; the possible causes of discrepancies are explored and explained. RELAP5 calculated system pressure, mass inventory, and fuel cladding temperature agree reasonably well with the experiment results, and only slight changes are noted between the double-blind and single-blind predictions

  16. LOFT/L3-, Loss of Fluid Test, 7. NRC L3 Small Break LOCA Experiment

    International Nuclear Information System (INIS)

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This was the seventh in the NRC L3 Series of small-break LOCA experiments. A 2.5-cm (10-in.) cold-leg non-communicative-break LOCA was simulated. The experiment was conducted on 20 June 1980

  17. Experiment data report for LOFT anticipated transient without scram Experiment L9-4

    International Nuclear Information System (INIS)

    Batt, D.L.; Divine, J.M.; McKenna, K.J.

    1982-11-01

    Selected pertinent and uninterpreted data from the fourth anticipated transient with multiple failures experiment (Experiment L9-4) conducted on September 24, 1982, in the Loss-of-Fluid Test (LOFT) facility are presented. The LOFT facility is a 50-MW(t) pressurized water reactor (PWR) system with instruments that measure and provide data on the system's thermal-hydraulic and nuclear conditions. The operation of the LOFT system is typical of large [approx. 1000 MW(e)], commercial PWR operations. Experiment L9-4 simulated a loss-of-offsite-power anticipated transient without reactor scram. The loss-of-offsite-power accident led to an increase in the primary coolant system temperature and pressure. The experiment safety relief valve opened and was able to limit and control the pressure transient. In addition, subsequent heat generation was dissipated by the auxiliary feedwater flow in the secondary coolant system until the reactor was scrammed at experiment termination

  18. LOFT fuel design and operating experience

    International Nuclear Information System (INIS)

    Russell, M.L.

    1978-01-01

    The purpose of the LOFT fuel is to provide a pressurized water reactor core that has (1) test instrumentation for measurement of core conditions and (2) materials and geometric features to ensure heat transfer, hydraulic, mechanical, chemical, metallurgical and nuclear behaviors are typical of large pressurized water reactors (LPWRS) during the loss-of-coolant accident (LOCA) sequence. The LOFT core is unique because it is designed for exposure to several LOCAs without loss of function

  19. Experiment data report for LOFT anticipated transient-without-scram Experiment L9-3

    International Nuclear Information System (INIS)

    Bayless, P.D.; Divine, J.M.

    1982-05-01

    Selected pertinent and uninterpreted data from the third anticipated transient with multiple failures experiment (Experiment L9-3) conducted in the Loss-of-Fluid Test (LOFT) facility are presented. The LOFT facility is a 50-MW(t) pressurized water reactor (PWR) system with instruments that measure and provide data on the system thermal-hydraulic and nuclear conditions. The operation of the LOFT system is typical of large [approx. 1000 MW(e)], commercial PWR operations. Experiment L9-3 simulated a loss-of-feedwater anticipated transient without scram. The loss-of-feedwater accident led to an increase in the primary coolant system temperature and pressure. Both the experiment power-operated relief valve (PORV) and safety relief valve opened and were able to limit and control the pressure transient. The plant was then recovered with the control rods still withdrawn by injecting 7200-ppM borated water, manually cycling the PORV and feeding and bleeding the steam generator

  20. LOFT/L3-6, Loss of Fluid Test, 6. NRC L3 Small Break LOCA Experiment

    International Nuclear Information System (INIS)

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This was the sixth in the NRC L3 Series of small-break LOCA experiments. A 10-cm (2.5-in.) cold-leg non-communicative-break LOCA was simulated. Pumps were running. The experiment was conducted on 10 December 1980

  1. LOFT/L3-5, Loss of Fluid Test, 5. NRC L3 Small Break LOCA Experiment

    International Nuclear Information System (INIS)

    1991-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This was the fifth in the NRC L3 Series of small-break LOCA experiments. A 10-cm (2.5-in.) cold-leg non-communicative-break LOCA was simulated. Pumps were shut off. The experiment was conducted on 29 September 1980

  2. PBF/LOFT Lead Rod Test Program experiment operating specification

    International Nuclear Information System (INIS)

    Varacalle, D.J. Jr.

    1978-11-01

    The PBF/LOFT Lead Rod (LLR) Test Program is being conducted to provide experimental information on the behavior of nuclear fuel under normal and accident conditions in the Power Burst Facility at the Idaho National Engineering Laboratory. Understanding the behavior of light-water reactors (LWR) under loss-of-coolant conditions is a major objective of the NRC Reactor Safety Research Program. The Loss of Fluid Test (LOFT) facility is the major testing facility to evaluate the systems response of an LWR over a wide range of Loss of Coolant Experment (LOCE) conditions. As such, the LOFT core is intended to be used for sequential LOCE tests provided no significant fuel rod failures occur. The PFB/LLR tests are designed to simulate the test conditions for the LOFT Power Ascension Tests L2-2 through L2-5. The test program has been designed to provide a parametric evaluation of the LOFT fuel over a wide range of power. Thus, a relatively accurate assessment of the state of the LOFT core after the completion of each subtest and the anticipated effect of the next test can be obtained by utilizing a combination of LLR test data and analytical predictions. Specifications for the test program are presented

  3. LOFT fuel design and operating experience

    International Nuclear Information System (INIS)

    Russell, M.L.

    1979-01-01

    The objective of the LOFT fuel design and fabrication effort was to provide a pressurized water reactor core that has (1) materials and geometric features to ensure that heat transfer, hydraulic, mechanical, chemical, metallurgical and nuclear behaviors are typical of large pressurized water reactors (PWR) during the loss-of-coolant accident (LOCA) sequence and (2) test instrumentation for measurement of core conditions. The LOFT core is unique because it is designed for exposure to several LOCAs without loss of function. This paper summarizes the design effort and extent to which the design objectives have been achieved

  4. LOFT fuel module structural response during loss-of-coolant experiments

    International Nuclear Information System (INIS)

    Saffell, B.F. Jr.; Selcho, H.S.

    1979-01-01

    The structural response of the reactor fuel modules installed in the Loss-of-Fluid Test (LOFT) facility have been analyzed for subcooled blowdown loading conditions associated with loss-of-coolant experiments (LOCE). Three independent analyses using the WHAM, SHOCK, and SAP computer codes have been interfaced to calculate the transient mechanical behavior of the LOFT fuel. Test data from two LOCEs indicate the analysis method is conservative. Structural integrity of the fuel modules has been assessed by monitoring guide tube temperatures and control rod drop times during the LOCEs. The analysis and experimental test data indicate the fuel module structural integrity will be maintained for the duration of the LOFT experimental program

  5. Assessment of the RELAP5 multi-dimensional component model using data from LOFT test L2-5

    International Nuclear Information System (INIS)

    Davis, C.B.

    1998-01-01

    The capability of the RELAP5-3D computer code to perform multi-dimensional analysis of a pressurized water reactor (PWR) was assessed using data from the LOFT L2-5 experiment. The LOFT facility was a 50 MW PWR that was designed to simulate the response of a commercial PWR during a loss-of-coolant accident. Test L2-5 simulated a 200% double-ended cold leg break with an immediate primary coolant pump trip. A three-dimensional model of the LOFT reactor vessel was developed. Calculations of the LOFT L2-5 experiment were performed using the RELAP5-3D Version BF02 computer code. The calculated thermal-hydraulic responses of the LOFT primary and secondary coolant systems were generally in reasonable agreement with the test. The calculated results were also generally as good as or better than those obtained previously with RELAP/MOD3

  6. Experiment data report for Loft anticipated transient experiments 16-1, 16-2, and 16-3

    International Nuclear Information System (INIS)

    Batt, D.L.; Carpenter, J.M.

    1980-12-01

    This report presents uninterpreted experimental data from the second, third, and fourth anticipated transient experiments (Experiments L6-2, L6-1, and L6-3), conducted in the Loss-of-Fluid Test (LOFT) facility. Experiment L6-2 simulated a loss of forced primary coolant flow in a large PWR by tripping power to primary coolant pump motor generator sets, allowing the pumps to coast down under the influence of the flywheel system. Reactor scram initiated on indication of low flow in the primary coolant system (PCS). Experiment L6-1 simulated a loss of steam load in a large PWR by closing the steam flow control valve which reduced heat removal from the secondary coolant system and caused the PCS temperature and pressure to increase until reactor scram initiated on indication on high PCS pressure. Experiment L6-3 simulated an excessive load increase in a large PWR by opening the steam flow control valve at its maximum rate. PCS temperature and pressure decreased, causing the reactor to scram on indication of low PCS pressure. All experiments were complete when the plant was returned to a hot-standby condition

  7. Assessment of RELAP5/MOD3.1 using LOFT L2-3 experiment data

    International Nuclear Information System (INIS)

    Lee, Sang Yong; Ban, Chang Hwan; Chung, Bob Dong

    1994-06-01

    The capability of RELAP5/MOD3.1 to predict overall LOCA thermal hydraulic phenomena was assessed utilizing the data of LOFT L2-3 experiment. Loop behaviors such as mass flow rate, water density, momentum flux, and the heating-up and rewetting of the fuel rod cladding during blowdown were well calculated. Reflood heat-up of the fuel rod cladding at the high power region of the core was reasonably predicted. But in the upper part of the core, cladding heat-up was calculated incorrectly since present code has no capability to calculate the top-down quenching which of highly multi-dimensional behavior. (Author) 10 refs., 46 figs., 2 tabs

  8. LOFT system structural response during subcooled blowdown

    International Nuclear Information System (INIS)

    Martinell, J.S.

    1978-01-01

    The Loss-of-Fluid Test (LOFT) facility is a highly instrumented, pressurized water reactor test system designed to be representative of large pressurized water reactors (LPWRs) for the simulation of loss-of-coolant accidents (LOCAs). Detailed structural analysis and appropriate instrumentation (accelerometers and strain gages) on the LOFT system provided information for evaluation of the structural response of the LOFT facility for loss-of-coolant experiment (LOCE) induced loads. In general, the response of the system during subcooled blowdown was small with typical structural accelerations below 2.0 G's and dynamic strains less than 150 x 10 - 6 m/m. The accelerations measured at the steam generator and simulated steam generator flange exceeded LOCE design values; however, integration of the accelerometer data at these locations yielded displacements which were less than one half of the design values associated with a safe shutdown earthquake (SSE), which assures structural integrity for LOCE loads. The existing measurement system was adequate for evaluation of the LOFT system response during the LOCEs. The conditions affecting blowdown loads during nuclear LOCEs will be nearly the same as those experienced during the nonnuclear LOCEs, and the characteristics of the structural response data in both types of experiments are expected to be the same. The LOFT system is concluded to be adequately designed and further analysis of the LOFT system with structural codes is not required for future LOCE experiments

  9. Experiment data report for LOFT nonnuclear Test L1-4

    International Nuclear Information System (INIS)

    Batt, D.L.

    1977-07-01

    Test L1-4 was the fourth in a series of five nonnuclear isothermal blowdown tests conducted by the Loss of Fluid Test (LOFT) Program. Test L1-4 was the first Nuclear Regulatory Commission standard problem (International Problem No. 5 and U.S. Problem No. 7) experiment conducted at LOFT. Data from this test will be compared with predictions generated by the standard problem participants. For this test the LOFT Facility was configured to simulate a loss-of-coolant accident in a large pressurized water reactor resulting from a 200% double-ended offset shear break in a cold leg of the primary coolant system. A hydraulic core simulator assembly was installed in place of the nuclear core. The initial conditions in the primary coolant system intact loop were temperature at 279 0 C, gauge pressure at 15.65 MPa, and intact loop flow at 268.4 kg/s. During system depressurization into a simulated containment, emergency core cooling water was injected into the primary coolant system cold leg to provide data on the effects of emergency core cooling on system thermalhydraulic response

  10. Analysis of core physics and thermal-hydraulics results of control rod withdrawal experiments in the LOFT facility

    International Nuclear Information System (INIS)

    Varacalle, D.J. Jr.; Chen, T.H.; Harvego, E.A.; Ollikkala, H.

    1983-01-01

    Two anticipated transient experiments simulating an uncontrolled control rod withdrawal event in a pressurized water reactor (PWR) were conducted in the Loss-of-Fluid Test (LOFT) Facility at the Idaho National Engineering Laboratory. The scaled LOFT 50-MW(t) PWR includes most of the principal features of larger commercial PWRs. The experiments tested the ability of reactor analysis codes to accurately calculate core reactor physics and thermal-hydraulic phenomena in an integral reactor system. The initial conditions and scaled operating parameters for the experiments were representative of those expected in a commercial PWR. In both experiments, all four LOFT control rod assemblies were withdrawn at a reactor power of 37.5 MW and a system pressure of 14.8 MPa

  11. Analysis of LOFT (L1-2) experiment by code RELAP-4J

    International Nuclear Information System (INIS)

    Tasaka, Kanji; Soda, Kunihisa; Shiba, Masayoshi; Kaminaga, Humito

    1977-04-01

    An analysis of the results in LOFT L1-2 LOCE (Loss of Coolant Experiment) was made by the computer code RELAP-4J. The L1-2 experiment is a simple isothermal blowdown test with a core simulator and no ECC activation. It provides the basis for future LOCE with a nuclear core and ECC activation. The results of the analysis lead to the following conclusions. (1) The calculated system pressure transient agrees well with experiment. Primary controlling factors for the calculation are (a) flow resistances of the steam generator simulator, pump simulator and discharge nozzle in the broken loop, (b) mixture level in the downcomer and inlet volume of the operating loop steam generator, and (c) stored heat of the downcomer structure. (2) The pressurizer pressure decreases rapidly, compared with experiment, possibly because the flow resistance in the surge line is smaller than the actual one. Further experiment and analysis are necessary in this respect. (3) The calculated density transient in the cold leg agrees well with experiment. Agreement is not good in the hot leg, however. The discrepancy is possibly caused by the non-homogeneous flow of coolant in the hot leg due to low flow rate. (4) Effect of the pump characteristics on analytical result is insignificant in the isothermal test. However, in the future nuclear test, the effect will be significant because of large steam generation in the core, so measurement of the pump characteristics and improvement of the pump model are necessary. (auth.)

  12. LOFT Augmented Operator Capability Program

    International Nuclear Information System (INIS)

    Hollenbeck, D.A.; Krantz, E.A.; Hunt, G.L.; Meyer, O.R.

    1980-01-01

    The outline of the LOFT Augmented Operator Capability Program is presented. This program utilizes the LOFT (Loss-of-Fluid Test) reactor facility which is located at the Idaho National Engineering Laboratory and the LOFT operational transient experiment series as a test bed for methods of enhancing the reactor operator's capability for safer operation. The design of an Operational Diagnotics and Display System is presented which was backfit to the existing data acquisition computers. Basic color-graphic displays of the process schematic and trend type are presented. In addition, displays were developed and are presented which represent safety state vector information. A task analysis method was applied to LOFT reactor operating procedures to test its usefulness in defining the operator's information needs and workload

  13. A Bayesian ensemble of sensitivity measures for severe accident modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hoseyni, Seyed Mohsen [Department of Basic Sciences, East Tehran Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Di Maio, Francesco, E-mail: francesco.dimaio@polimi.it [Energy Department, Politecnico di Milano, Via La Masa 34, 20156 Milano (Italy); Vagnoli, Matteo [Energy Department, Politecnico di Milano, Via La Masa 34, 20156 Milano (Italy); Zio, Enrico [Energy Department, Politecnico di Milano, Via La Masa 34, 20156 Milano (Italy); Chair on System Science and Energetic Challenge, Fondation EDF – Electricite de France Ecole Centrale, Paris, and Supelec, Paris (France); Pourgol-Mohammad, Mohammad [Department of Mechanical Engineering, Sahand University of Technology, Tabriz (Iran, Islamic Republic of)

    2015-12-15

    Highlights: • We propose a sensitivity analysis (SA) method based on a Bayesian updating scheme. • The Bayesian updating schemes adjourns an ensemble of sensitivity measures. • Bootstrap replicates of a severe accident code output are fed to the Bayesian scheme. • The MELCOR code simulates the fission products release of LOFT LP-FP-2 experiment. • Results are compared with those of traditional SA methods. - Abstract: In this work, a sensitivity analysis framework is presented to identify the relevant input variables of a severe accident code, based on an incremental Bayesian ensemble updating method. The proposed methodology entails: (i) the propagation of the uncertainty in the input variables through the severe accident code; (ii) the collection of bootstrap replicates of the input and output of limited number of simulations for building a set of finite mixture models (FMMs) for approximating the probability density function (pdf) of the severe accident code output of the replicates; (iii) for each FMM, the calculation of an ensemble of sensitivity measures (i.e., input saliency, Hellinger distance and Kullback–Leibler divergence) and the updating when a new piece of evidence arrives, by a Bayesian scheme, based on the Bradley–Terry model for ranking the most relevant input model variables. An application is given with respect to a limited number of simulations of a MELCOR severe accident model describing the fission products release in the LP-FP-2 experiment of the loss of fluid test (LOFT) facility, which is a scaled-down facility of a pressurized water reactor (PWR).

  14. Anticipated transient without SCRAM experiments at LOFT

    International Nuclear Information System (INIS)

    Grush, W.H.; Harvego, E.A.; Koizumi, Y.; Varacalle, D.J.

    1983-01-01

    This paper discusses the experimental results for two anticipated transients without scram (ATWS) experiments, and compares computer code predictions with the experimental data. Experiment L9-3 simulated an ATWS in a commercial pressurized water reactor (PWR) initiated by a complete loss of feedwater and Experiment L9-4 simulated a loss-of-offsite-power-initiated (loss of feedwater and trip of the primary coolant pumps) ATWS. The LOFT facility is uniquely suited for ATWS experiments because it is a volumetrically scaled (1/44) experimental PWR designed to simulate the major components and system responses of larger commercial PWRs during both hypothesized loss-of-coolant accidents and anticipated transients. In both of the examined experiments, the primary system transient behavior was dominated by the interactions between the steam generator primary-to-secondary heat removal, the reactor kinetics, and the relief valve actuation. It is demonstrated that the discussed ATWS events can be controlled by properly sized automatic safety systems

  15. Experiment data report for LOFT nonnuclear test L1-3

    International Nuclear Information System (INIS)

    Millar, G.M.

    1977-04-01

    Test L1-3 was the third in a series of five nonnuclear isothermal blowdown tests conducted by the Loss of Fluid Test (LOFT) Program. For this test the LOFT Facility was configured to simulate a loss-of-coolant accident in a large pressurized water reactor resulting from a 200 percent double-ended shear break in a cold leg of the primary coolant system. A hydraulic core simulator assembly was installed in place of the nuclear core. The initial conditions in the primary coolant system intact loop were: temperature at 540 0 F, pressure at 2256 psig, and loop flow at 2.34 x 10 6 lbm/hr. During system depressurization, emergency core cooling water was specified to be injected into the lower plenum of the reactor vessel using an accumulator, a low-pressure injection system pump, and a high-pressure injection system pump to provide data on the effects of emergency core cooling on the system thermal-hydraulic response. Injection into the lower plenum was initiated from the high- and low-pressure injection systems. Injection from the accumulator, however, was not initiated because a valve was inadvertently left closed. The experiment, therefore, was not completely successful in that one of the objectives outlined in the experiment operating specification for this test was not accomplished. Test L1-3 was repeated at Test L1-3A to meet the experimental requirements. Despite these difficulties, Test L1-3 did provide very valuable data to verify experiment repeatability

  16. Simulation of COMEDIE Fission Product Plateout Experiment Using GAMMA-FP

    International Nuclear Information System (INIS)

    Tak, Nam-il; Yoon, Churl

    2014-01-01

    FThis phenomenon is particularly important under a VHTR design with vented low pressure confinement (VLPC), because the vent allows the prompt release of fission products accumulated within the primary circuit to environment during an initial blow-down phase after pipe break accidents. In order to analyze the fission product plateout, an numerical model was developed by Yoo et al. and incorporated into the GAMMA-FP code in the past. The GAMMA-FP model was validated against two experiment data, i.e., VAMPYR-1 and OGL, during the development phase. One of the well-known experiments for fission product plateout is the COMEDIE experiment. In this work, the COMEDIE experiment has been simulated using the GAMMA-FP code to investigate the reliability and applicability of the plateout model of GAMMA-FP. The COMEDIE experiment for fission product plateout was simulated using the GAMMA-FP code in this work. A good agreement was achieved between the measured and predicted plateout activities. The existing solution scheme was modified to allow larger time step size for fission product analysis in order to speed-up the computational time. Nevertheless, the modification of the existing numerical model of GAMMA-FP is necessary when a simulation capability of a long duration of plateout period (e.g., 60 years) is targeted

  17. LOFT data reduction

    International Nuclear Information System (INIS)

    Norman, N.L.

    1975-08-01

    The Loss-of-Fluid Test (LOFT) Facility is an experimental facility built around a ''scaled'' version of a large pressurized water reactor (LPWR). LOFT will be used to run loss-of-coolant experiments (LOCEs) and to acquire the necessary data required ''to evaluate the adequacy and improve the analytical methods currently used to predict the loss-of-coolant accident (LOCA) response of LPWRs'' and ''to identify and investigate any unexpected event(s) or threshold(s) in the response of either the plant or the engineered safety features and develop analytical techniques that adequately describe and account for the unexpected behavior(s)''. During the LOCE this required data will be acquired and recorded in both analog and digital modes. Subsequent to the test the analog data will also be converted to the raw digital mode. This raw digital data will be converted to the desired engineering units using the LOFT Data Reduction System. This system is implemented on the IBM 360/75 and is a part of a commercially available data processing program called MAC/RAN III. The theory of reducing LOFT data to engineering units and the application of the MAC/ RAN III system to accomplish this reduction is given. (auth)

  18. Experiment data report for semiscale Mod-1 Test S-06-2 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Patton, M.L. Jr.; Collins, B.L.; Sackett, K.E.

    1977-08-01

    Recorded test data are presented for Test S-06-2 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-2 was conducted from initial conditions of 15 513 kPa and 563 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 50% of the maximum peak power density

  19. Requalification of the LOFT reactor following a loss of coolant experiment (Level I)

    International Nuclear Information System (INIS)

    Cannon, J.W.

    1979-01-01

    During a Loss of Coolant Experiment (LOCE), the LOFT reactor experiences an acceleration of 10 G's and fuel cladding temperature changes at a rate of 1100 0 K/sec. These unparalleled conditions present a unique startup problem to the LOFT program: How can the integrity of the fuel be confirmed so as to minimize operation if damage has occurred. The Level I Requalification Program is designed to accomplish this. It is a progressive series of tests, designed to detect damage at the earliest possible time, and thus preclude or minimize operation if damage exists. First, fuel specialists examine the LOCE data for possible damaging conditions and the results of primary coolant sample analysis for signs of failed fuel. Second, the requalification program proceeds to a series of mechanical and physics tests

  20. RELAP5/MOD2 analysis of LOFT Experiment L9-3

    International Nuclear Information System (INIS)

    Birchley, J.C.

    1992-04-01

    An analysis has been performed of LOFT Experiment L9-3, a loss-of-feedwater anticipated transient without trip, in order to support the validation of RELAP5/MOD2. Experiment L9-3 exhibited a rapid boildown of the steam generator, following the loss of feed, with the reactor remaining close to its initial power until the steam generator tubes became sufficiently uncovered for primary to secondary heat transfer to be significantly reduced. The ensuing heat up of the primary fluid resulted in a reduction in power induced by the moderator feedback. The primary system pressure increased to the safety relief valve setpoint, before the fall in reactor power allowed the mismatch between primary system heat input and heat removal via the steam generator to be accommodated by cycling of the pilot operated relief valve (PORV). Comparison between calculation and data shows generally good agreement, though with discrepancies in some areas. Weaknesses in the code's treatment of interphase drag and in the representation of the pressuriser spray are indicated, although a shortage of definitive data, particularly in the steam generator, may also be a factor. The overprediction of interphase drag led to a tendency to underpredict the initial inventory in the steam generator and also, perhaps, to overpredict the steam generator heat transfer while the tubes were being uncovered. There is indication that the pressuriser vapour region conditions were close to equilibrium during spray operation. The point kinetics model in RELAP5/MOD2 proved a viable means of representing the power history for this transient

  1. Scaling and instrumentation of the LOFT facility

    International Nuclear Information System (INIS)

    Modro, S.M.; Goodrich, L.D.; McPherson, G.D.

    1985-01-01

    This paper describes the LOFT experimental facility and instrumentation of the facility during small break loss-of-coolant experiments. Basic scaling considerations applied in the facility design are presented. Because LOFT was not designed with emphasis on small break LOCA some atypicalities with regard to small break transients are discussed. Review of important small break LOCA phenomena observed during the experiments and their measurability is provided

  2. Prediction of LOFT L1-4 experiment

    International Nuclear Information System (INIS)

    Soda, Kunihisa; Sasaki, Shinobu; Akimoto, Masayuki; Koizumi, Yasuo; Araya, Fumimasa

    1977-10-01

    LOFT L1-4 experimental results were predicted by LOFT Analysis Group and Code Development Group using RELAP-4J and ALARM-P1 respectively. The input data prepared by the former group were used in both the analyses. Thus any differences in the results should stem from the differences in code performance characteristics of the two codes. (1) The coolant behaviors predicted by RELAP-4J and ALARM-P1 are in good agreement although some differences do exist between these two calculation models. (2) Large difference is seen in coolant flow rate across the pump. The coast down and the flow rate by ALARM-P1 are larger and smaller respectively than by RELAP-4J. (3) An explicit method of the ALARM-P1 leads to unstable calculation at a T shaped junction when one of the two volumes connected by the junction is filled with subcooled water. (4) Coolant flow in the downcomer, heat transfer to and from the steam generator secondary and suppression tank behavior must be modified to better predict the experimental results. (5) Additional instrumentation in reflood assist and ECC injection lines are necessary to better nderstand the coolant behavior. (auth.)

  3. PWR fuel behavior: lessons learned from LOFT

    International Nuclear Information System (INIS)

    Russell, M.L.

    1981-01-01

    A summary of the experience with the Loss-of-Fluid Test (LOFT) fuel during loss-of-coolant experiments (LOCEs), operational and overpower transient tests and steady-state operation is presented. LOFT provides unique capabilities for obtaining pressurized water reactor (PWR) fuel behavior information because it features the representative thermal-hydraulic conditions which control fuel behavior during transient conditions and an elaborate measurement system to record the history of the fuel behavior

  4. LOFT drag-disc turbine tansducer shroud and cover weld analysis and evaluation

    International Nuclear Information System (INIS)

    Martinell, J.S.

    1978-01-01

    The results are presented of stress analysis and evaluation of the drag-disc turbine transducer (DTT) shroud and cover welds used in the Loss-of-Fluid Test (LOFT) facility. The analysis concerns LOFT DTTs currently installed and/or planned for use in future experiments by LOFT Experimental Measurements Branch personnel. Thermal/hydraulic conditions for Experiments L1-5 and L2-4 (for all nuclear tests) were used to predict the loads experienced by the various shroud and cover welds. The results of this analysis include minimum fatigue life for all subject welds, and Applied Mechanics Branch recommendations for improving the structural integrity of critically stressed welds

  5. LOFT/L9-3, Loss of Fluid Test, Anticipated Transients with Multiple Failures

    International Nuclear Information System (INIS)

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This was the third of the NRC L9 series of experiments on Anticipated Transients with Multiple Failures. Loss-of-feedwater effects were studied. The experiment was conducted on 7 April 1982

  6. LOFT/L6-7, Loss of Fluid Test, Anticipated Transients with Multiple Failures

    International Nuclear Information System (INIS)

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This was the seventh in the NRC L6 Series of Anticipated Transients experiments. Rapid secondary side induced cooldown was studied. The experiment was conducted on 31 September 1981

  7. Experiment data report for LOFT Boron dilution Experiment L6-6

    International Nuclear Information System (INIS)

    Stitt, B.D.; Divine, J.M.

    1982-06-01

    Selected pertinent and uninterpreted data from the sixth anticipated transient experiment (Experiment L6-6) conducted in the Loss-of-Fluid Test (LOFT) facility are presented. Experiment L6-6 simulated a boron dilution accident by injecting demineralized water into the primary coolant system (PCS) at a rate of 0.47 L/s while the reactor was in a cold shutdown condition with the control rods withdrawn. System pressure was maintained at approximately 285 kPa throughout the experiment. The experiment was divided into two parts. In the first part, L6-6A, a recirculation flow of 4.7 L/s was maintained through the PCS and criticality was achieved 7416 +- 10 s after the initiation of the dilution flow. The second part, L6-6B, was identical to L6-6A except that a recirculation flow of 9.5 L/s was maintained and criticality occurred at 8058 +- 10 s

  8. Multidimensional analysis of fluid flow in the loft cold leg blowdown pipe during a loss-of-coolant experiment

    International Nuclear Information System (INIS)

    Demmie, P.N.; Hofmann, K.R.

    1979-03-01

    A computer analysis of fluid flow in the Loss-of-Fluid Test (LOFT) cold leg blowdown pipe during a loss-of-coolant experiment (LOCE) was performed using the computer program K-FIX/MOD1. The purpose of this analysis was to evaluate the capability of K-FIX/MOD1 to calculate theoretical fluid quantity distributions in the blowdown pipe during a LOCE for possible application to the analysis of LOFT experimental data, the determination of mass flow, or the development of data reduction models. A rectangular section of a portion of the LOFT blowdown pipe containing measurement Station BL-1 was modeled using time-dependent boundary conditions. Fluid quantities were calculated during a simulation of the first 26 s of LOFT LOCE L1-4. Sensitivity studies were made to determine changes in void fractions and velocities resulting from specific changes in the inflow boundary conditions used for this simulation

  9. LOFT instrumentation

    International Nuclear Information System (INIS)

    Bixby, W.W.

    1979-01-01

    A description of instrumentation used in the Loss-of-Fluid Test (LOFT) large break Loss-of-Coolant Experiments is presented. Emphasis is placed on hydraulic and thermal measurements in the primary system piping and components, reactor vessel, and pressure suppression system. In addition, instrumentation which is being considered for measurement of phenomena during future small break testing is discussed. (orig.) 891 HP/orig. 892 BRE [de

  10. LOFT fuel rod surface temperature measurement testing

    International Nuclear Information System (INIS)

    Eaton, A.M.; Tolman, E.L.; Solbrig, C.W.

    1978-01-01

    Testing of the LOFT fuel rod cladding surface thermocouples has been performed to evaluate how accurately the LOFT thermocouples measure the cladding surface temperature during a loss-of-coolant accident (LOCA) sequence and what effect, if any, the thermocouple would have on core performance. Extensive testing has been done to characterize the thermocouple design. Thermal cycling and corrosion testing of the thermocouple weld design have provided an expected lifetime of 6000 hours when exposed to reactor coolant conditions of 620 K and 15.9 MPa and to sixteen thermal cycles with an initial temperature of 480 K and peak temperatures ranging from 870 to 1200K. Departure from nucleate boiling (DNB) tests have indicated a DNB penalty (5 to 28% lower) during steady state operation and negligible effects during LOCA blowdown caused by the LOFT fuel rod surface thermocouple arrangement. Experience with the thermocouple design in Power Burst Facility (PBF) and LOFT nonnuclear blowdown testing has been quite satisfactory. Tests discussed here were conducted using both stainless steel and zircaloy-clad electrically heated rod in the LOFT Test Support Facility (LTSF) blowdown simulation loop

  11. Benchmarking of LOFT LRTS-COBRA-FRAP safety analysis model

    International Nuclear Information System (INIS)

    Hanson, G.H.; Atkinson, S.A.; Wadkins, R.P.

    1982-05-01

    The purpose of this work was to check out the LOFT LRTS/COBRA-IV/FRAP-T5 safety-analysis models against test data obtained during a LOFT operational transient in which there was a power and fuel-temperature rise. LOFT Experiment L6-3 was an excessive-load-increase anticipated transient test in which the main steam-flow-control valve was driven from its operational position to full-open in seven seconds. The resulting cooldown and reactivity-increase transients provide a good benchmark for the reactivity-and-power-prediction capability of the LRTS calculations, and for the fuel-bundle and fuel-rod temperature-response analysis capability of the LOFT COBRA-IV and FRAP-T5 models

  12. Comparison of the quench experiments CORA-12, CORA-13, CORA-17

    International Nuclear Information System (INIS)

    Hagen, S.; Hofmann, P.; Noack, V.; Sepold, L.; Schanz, G.; Schumacher, G.

    1996-08-01

    The CORA quench experiments 12, 13 (PWR) und 17 (BWR) are in agreement with the inpile tests LOFT LP-FP-2 and PBF SFD-ST and the TMI accident: Flooding of hot Zircaloy clad fuel rods does not result in an immediate cooldown of the bundle, but produces a remarkable temporary temperature increase connected to a strong peak in hydrogen production. For the preparation of new quench bundle tests, necessary for the understanding of the mechanisms governing the quench process and support for validation of future quench models in SFD codes the three tests are compared to each other and to the relevant non-quench tests CORA-29 (PWR) and CORA-16 (BWR). The PWR tests CORA-12 and CORA-13 are of the same geometrical arrangement and test conduct. An exception is the shorter time between power shutdown and quench initiation for CORA 13, resulting in a higher temperature of the bundle at start of quenching. The BWR test CORA-17 used B 4 C absorber and Zircaloy channel box walls, but was in respect to the delay time between power shutdown and start of quenching similar to test CORA-12. (orig./GL) [de

  13. LOFCON-LOFT condenser program

    International Nuclear Information System (INIS)

    Lemmon, E.C.; MacKay, D.B.

    1978-01-01

    LOFCON is a program developed for the LOFT air condenser system contained in the secondary coolant system. Although the basic theory described herein is general, the program given is not--it is specifically for the LOFT configuration. LOFCON is presented in subroutine form so that it may be easily incorporated into a larger program describing the complete secondary side. Specifically LOFCON was written to be incorporated into the detailed CSMP model of the LOFT secondary coolant system simulation

  14. Overview of LOFT instrumentation

    International Nuclear Information System (INIS)

    Bixby, W.W.

    1979-01-01

    A description of instrumentation used in the Loss-of-Fluid Test (LOFT) large break Loss-of-Coolant Experiments is presented. Emphasis is placed on hydraulic and thermal measurements in the primary system piping and components, reactor vessel, and pressure suppression system. In addition, instrumentation which is being considered for measurement of phenomena during future small break testing is discussed

  15. LOFT advanced densitometer for nuclear loss-of-coolant experiments

    International Nuclear Information System (INIS)

    Johnson, L.O.; Lassahn, G.D.; Wood, D.B.

    1979-01-01

    A ''nuclear hardened'' gamma densitometer, a device which uses radiation attenuation to measure fluid density in the presence of a background radiation field, is described. Data from the nuclear hardened gamma densitometer are acquired by time sampling the coolant fluid piping and fluid attenuated source energy spectrum. The data are used to calculate transient coolant fluid cross sectional average density to analyze transient mass flow and other thermal-hydraulic characteristics during the Loss-of-Fluid Test (LOFT) loss-of-coolant experiments. The nuclear hardened gamma densitometer uses a pulse height analysis or energy discrimination, pulse counting technique which makes separation of the gamma radiation source signal from the reactor generated gamma radiation background noise signal possible by processing discrete pulses which retain their pulse amplitude information

  16. Prediction of LOFT core fluid conditions during blowdown and refill

    International Nuclear Information System (INIS)

    Grush, W.H.; White, J.R.

    1978-01-01

    One of the primary objectives of the LOFT (Loss-of-Fluid Test) Program is to provide data required to evaluate and improve the analytical methods currently used to predict the LOCA (Loss-of-Coolant Accident) response of large pressurized water reactors. The purpose of the paper is to describe the computer modeling methods used in predicting the fluid conditions in the LOFT core during the blowdown and refill phases of a nuclear LOCE (Loss-of-Coolant Experiment). Prediction results for a LOFT nonnuclear isothermal LOCE are compared to the experimental data to illustrate the validity of the modeling choices

  17. TRAC-PD2 modeling of LOFT and PWR small cold-leg breaks

    International Nuclear Information System (INIS)

    Knight, T.D.; Willcutt, G.J.E. Jr.; Lime, J.F.

    1981-01-01

    The Transient Reactor Analysis Code (TRAC) is being developed at the Los Alamos National Laboratory to provide advanced best-estimate predictions of postulated accidents in light-water reactors. TRAC-PD2, the latest publicly released version of the code, is currently being tested against small-break and other transients in experimental facilities; it is also being used to analyze postulated accidents in commercial power reactors. Calculated results for LOFT small-break experiments are compared to data, and the results from two small-break calculations for two different reactor systems are presented. It is concluded that TRAC-PD2 is useful for the analysis of cold-leg small-break accidents

  18. LOFT Engineering Simulator

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1982-02-01

    The LOFT Engineering Simulator was developed to supply plant equivalent data for evaluating graphic aids and advanced control concepts for nuclear plant operators. The Simulator, a combination of hardware and software, combines some of the features of best estimate (safety analysis) computer codes with reactor operator training simulators. The LOFT Engineering Simulator represents an attempt to develop a simulation with sufficient physical detail (solution of the conservation equations) for moderate accident simulation, but which will still run in real time and provide an interface for the operator to interact with the model. As a result of this combination, a real time simulation of the LOFT plant has been developed which yields realistic transient results. These data can be used for evaluating reactor control room aids such as Safety Parameter Displays and Janus Predictive Displays

  19. The LOFT Ground Segment

    DEFF Research Database (Denmark)

    Bozzo, E.; Antonelli, A.; Argan, A.

    2014-01-01

    targets per orbit (~90 minutes), providing roughly ~80 GB of proprietary data per day (the proprietary period will be 12 months). The WFM continuously monitors about 1/3 of the sky at a time and provides data for about ~100 sources a day, resulting in a total of ~20 GB of additional telemetry. The LOFT...... Burst alert System additionally identifies on-board bright impulsive events (e.g., Gamma-ray Bursts, GRBs) and broadcasts the corresponding position and trigger time to the ground using a dedicated system of ~15 VHF receivers. All WFM data are planned to be made public immediately. In this contribution...... we summarize the planned organization of the LOFT ground segment (GS), as established in the mission Yellow Book 1 . We describe the expected GS contributions from ESA and the LOFT consortium. A review is provided of the planned LOFT data products and the details of the data flow, archiving...

  20. RELAP5/MOD2 code assessment using a LOFT L2-3 loss of coolant experiment

    International Nuclear Information System (INIS)

    Bang, Young Seok; Chung, Bub Dong; Kim, Hho Jung

    1990-01-01

    The LOFT LOCE L2-3 was simulated using the RELAP5/MOD2 Cycle 36.04 code to assess its capability in predicting the thermal-hydraulic phenomena in LBLOCA of the PWR. The reactor vessel was simulated with two core channels and split downcomer modeling for a base case calculation using the frozen code. The result of the base calculation showed that the code predicted the hydraulic behavior, and the blowdown thermal response at high power region of the core in a reasonable range and that the code had deficiencies in the critical flow model during subcooled-two-phase transition period, in the CHF correlation at high mass flux and in the blowdown rewet criteria. An overprediction of coolant inventory due to the deficiencies yielded the poor prediction of reflood thermal response. A Sensitivity calculation with an updated version from RELAP5/MOD2 Cycle 36.04 improved the prediction of the rewet phenomena

  1. A review of radionuclide release and transport in recent in-pile experiments

    International Nuclear Information System (INIS)

    Harman, N.F.; Clough, P.N.

    1992-01-01

    The experimental series, reviewed in this work, are LOFT-LP-FP-2, PBF SFD ST to 1-4, Treat/STEP I to 4, and ACRR ST-1 and ST-2. These have the common features of in-core heating of a test fuel bundle to high temperatures (usually with some fuel melting) in an experimental reactor core, and of collecting and analysing the released fission products. They were designed to provide detailed information on the release from fuel of fission products and other radionuclides under LWR severe accident conditions, and on the chemical and physical forms and transport of the fission products. The main aim of this review is to bring together, in a systematic way, information on the conduct of the tests, on their successes and failures, and particularly on the information they generated on the chemical and physical behaviour of released fission products. By examining and analysing the data from all of the tests together, patterns of fission product behaviour may become apparent and insights may be gained, which would not be arrived at from individual test results. Moreover, important lessons may be learned, and useful guidance obtained, relating to the aims and conduct of future experimental programmes of fission product release from fuel and transport behaviour. The conclusions should be particularly relevant to the imminent Phebus-FP in-pile test series at Cadarache

  2. LOFT voltage insertion calibaration program

    International Nuclear Information System (INIS)

    Tillitt, D.N.; Miyasaki, F.S.

    1975-08-01

    The Loss-of-Fluid Test (LOFT) Facility is an experimental facility built around a ''scaled'' version of a large pressurized water reactor (LPWR). Part of this facility is the Data Acquisition and Visual Display System (DAVDS) as defined by the LOFT System Design Document SDD 1.4.2C. The DAVDS has a 702 data channel recording capability of which 548 are recorded digitally. The DAVDS also contains a Voltage Insertion Calibration Subsystem used to inject precise and known voltage steps into the recording systems. The computer program that controls the Voltage Insertion Calibration Subsystem is presented. 7 references. (auth)

  3. Genetic invalidation of Lp-PLA2 as a therapeutic target

    DEFF Research Database (Denmark)

    Gregson, John M; Freitag, Daniel F; Surendran, Praveen

    2017-01-01

    AIMS: Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. METHODS: In 72...... (Val379Ala (rs1051931)) in PLA2G7, the gene encoding Lp-PLA2. We supplemented de-novo genotyping with information on a further 45,823 coronary heart disease patients and 88,680 controls in publicly available databases and other previous studies. We conducted a systematic review of randomized trials...... to compare effects of darapladib treatment on soluble Lp-PLA2 activity, conventional cardiovascular risk factors, and coronary heart disease risk with corresponding effects of Lp-PLA2-lowering alleles. RESULTS: Lp-PLA2 activity was decreased by 64% (p = 2.4 × 10(-25)) with carriage of any of the four loss...

  4. Transient two-phase performance of LOFT reactor coolant pumps

    International Nuclear Information System (INIS)

    Chen, T.H.; Modro, S.M.

    1983-01-01

    Performance characteristics of Loss-of-Fluid Test (LOFT) reactor coolant pumps under transient two-phase flow conditions were obtained based on the analysis of two large and small break loss-of-coolant experiments conducted at the LOFT facility. Emphasis is placed on the evaluation of the transient two-phase flow effects on the LOFT reactor coolant pump performance during the first quadrant operation. The measured pump characteristics are presented as functions of pump void fraction which was determined based on the measured density. The calculated pump characteristics such as pump head, torque (or hydraulic torque), and efficiency are also determined as functions of pump void fractions. The importance of accurate modeling of the reactor coolant pump performance under two-phase conditions is addressed. The analytical pump model, currently used in most reactor analysis codes to predict transient two-phase pump behavior, is assessed

  5. Through analysis of LOFT L2-3 by THYDE-P code

    International Nuclear Information System (INIS)

    Hirano, Masashi

    1981-10-01

    A through calculation of Experiment L2-3 of the Loss-of-Fluid Test (LOFT) Facility Power Ascension Series (Experiment Series L2) was performed with the THYDE-P code. The specific objectives of Experiment L2-3 were to determine the thermal-hydraulic behavior of the nuclear core and the thermal-mechanical response of the fuel rod cladding with a maximum linear heat generation rate of 39.4 kW/m. The THYDE-P code is a computer code to analyze both the blowdown and refill-reflood phases of loss-of-coolant accidents (LOCAs) of pressurized water reactors (PWRs) without a change in the methods and the models and is now under verification study and modification. The present calculation was performed by best estimate (BE) options as Sample Calculation Run 40, which is a portion of a series of THYDE-P sample calculations. The calculation was carried out from test initiation until complete submersion of the core volume with subcooled water, i.e. about 60 sec. The trend of the calculated cladding surface temperature was in good agreement with that of the experimental results. (author)

  6. Potential of LOFT telescope for the search of dark matter

    CERN Document Server

    Neronov, A; Iakubovskyi, D.; Ruchayskiy, O.

    2014-01-01

    Large Observatory For X-ray Timing (LOFT) is a next generation X-ray telescope selected by European Space Agency as one of the space mission concepts within the ``Cosmic Vision'' programme. The Large Area Detector on board of LOFT will be a collimator-type telescope with an unprecedentedly large collecting area of about 10 square meters in the energy band between 2 and 100 keV. We demonstrate that LOFT will be a powerful dark matter detector, suitable for the search of the X-ray line emission expected from decays of light dark matter particles in galactic halos. We show that LOFT will have sensitivity for dark matter line search more than an order of magnitude higher than that of all existing X-ray telescopes. In this way, LOFT will be able to provide a new insight into the fundamental problem of the nature of dark matter.

  7. Report of the LOFT special review group. Technical report

    International Nuclear Information System (INIS)

    Ross, D.F. Jr.

    1981-02-01

    This report represents the results of the LOFT Special Review Group (LSRG) evaluation of the LOFT program and is submitted to the Commission as an aid in its decision whether to continue NRC support of the LOFT project beyond FY 1982. The principal consensus reached by the LSRG recommends continued NRC support of the LOFT program through FY 1983

  8. Core-power and decay-time limits for disabled automatic-actuation of LOFT ECCS

    International Nuclear Information System (INIS)

    Hanson, G.H.

    1978-01-01

    The Emergency Core Cooling System (ECCS) for the LOFT reactor may need to be disabled for modifications or repairs of hardware or instrumentation or for component testing during periods when the reactor system is hot and pressurized, or it may be desirable to enable the ECCS to be disabled without the necessity of cooling down and depressurizing the reactor. A policy involves disabling the automatic-actuation of the LOFT ECCS, but still retaining the manual actuation capability. Disabling of the automatic actuation can be safely utilized, without subjecting the fuel cladding to unacceptable temperatures, when the LOFT power decays to 33 kW; this power level permits a maximum delay of 20 minutes following a LOCA for the manual actuation of ECCS. For the operating power of the L2-2 Experiment, the required decay-periods (with operating periods of 40 and 2000 hours) are about 21 and 389 hours, respectively. With operating periods of 40 and 2000 hours at Core-I full power, the required decay-periods are about 42 and 973 hours, respectively. After these decay periods the automatic actuation of the LOFT ECCS can be disabled assuming a maximum delay of 20 minutes following a LOCA for the manual actuation of ECCS. The automatic and manual lineup of the ECCS may be waived if decay power is less than 11 kW

  9. The Lp Lp Lp-curvature images of convex bodies and Lp Lp Lp

    Indian Academy of Sciences (India)

    Associated with the Lp-curvature image defined by Lutwak, some inequali- ... theory. With it, Lutwak [10] generalized many affine isoperimetric inequalities from their ... For quick reference, we recall some basic properties of Lp-mixed and dual ...

  10. Posttest REALP4 analysis of LOFT experiment L1-3A

    International Nuclear Information System (INIS)

    White, J.R.; Holmstrom, H.L.O.

    1977-10-01

    This report presents selected results of posttest RELAP4 modeling of LOFT loss-of-coolant experiment L1-3A, a double-ended isothermal cold leg break with lower plenum emergency core coolant injection. Comparisons are presented between the pretest prediction, the posttest analysis, and the experimental data. It is concluded that pressurizer modeling is important for accurately predicting system behavior during the initial portion of saturated blowdown. Using measured initial conditions rather than nominal specified initial conditions did not influence the system model results significantly. Using finer nodalization in the reactor vessel improved the prediction of the system pressure history by minimizing steam condensation effects. Unequal steam condensation between the downcomer and core volumes appear to cause the manometer oscillations observed in both the pretest and posttest RELAP4 analysis

  11. LOFT: a nuclear plant providing realistic answers to PWR licensing issues

    Energy Technology Data Exchange (ETDEWEB)

    Solbrig, C.W.

    1980-01-01

    The following topics are discussed: the LOFT mission; LOFT results which have been used by NRC's office of Nuclear Reactor Regulation (NRR); NRR current LOFT information needs; and the channels of LOFT results dissemination.

  12. Progress report on LOFT rake designs

    International Nuclear Information System (INIS)

    Bearden, R.G.

    1977-01-01

    Evaluation of data from Loss-of-Fluid Test (LOFT) nonnuclear tests has shown a need for profile measurements at several locations in the LOFT piping. A prototype rake consisting of three Drag-Disc Turbine Transducers (DTT) has been designed and fabricated for installation at one location (FE-BL-1) in the blowdown loop. After successful operation during a LOFT nonnuclear test (L1-4) scheduled for May, 1977, additional rakes will be installed in the primary and blowdown loops. A research program to develop a pitot tube rake for measurement of steady state and transient two-phase flows is in progress at McMaster University, Hamilton, Ontario. A rake of thermocouples and pitot tubes will be developed for installation near the emergency core coolant (ECC) injection points

  13. LOFT transient thermal analysis for 10 inch primary coolant blowdown piping weld

    International Nuclear Information System (INIS)

    Howell, S.K.

    1978-01-01

    A flaw in a weld in the 10 inch primary coolant blowdown piping was discovered by LOFT personnel. As a result of this, a thermal analysis and fracture mechanics analysis was requested by LOFT personnel. The weld and pipe section were analyzed for a complete thermal cycle, heatup and Loss of Coolant Experiment (LOCE), using COUPLE/MOD2, a two-dimensional finite element heat conduction code. The finite element representation used in this analysis was generated by the Applied Mechanics Branch. The record of nodal temperatures for the entire transient was written on tape VSN=T9N054, and has been forwarded to the Applied Mechanics Branch for use in their mechanical analysis. Specific details and assumptions used in this analysis are found in appropriate sections of this report

  14. NEPTUN/5052, PWR LOCA Cooling Heat Transfer Tests for Loft, Reflood Test

    International Nuclear Information System (INIS)

    Richner, M.; Analytis, G.Th.; Aksan, S.N.

    1993-01-01

    1 - Description of test facility: NEPTUN is designed to perform PWR LOCA simulation experiments, which provide the full length emergency cooling heat transfer tests for LOFT. Therefore the NEPTUN heater bundle with 33 electrical heater elements and 4 guide tubes simulates a section of the LOFT nuclear core. The main test loop also contains measuring systems for the carry-over rate and for the steam expelled, and a back-pressure control system. A water loop brings the water to the initial reflooding conditions. In addition, auxiliary systems maintain normal operating conditions. 2 - Description of test: Test 5052 is one of a series of 40 reflood tests performed in NEPTUN. Before the start of the test, the flooding water in its circuit is brought to the following conditions: pressure = 4.1 bar; velocity = 2.5 cm/sec; subcooling temperature = 78 C; single rod power = 2.45 kW; maximal initial cladding temperature = 867 C. 3 - Status: CSNI1013/01, 21-Jul-1993 Arrived at NEADB

  15. Plasma Lp-PLA2 mass and apoB-lipoproteins that carry Lp-PLA2 decrease after sodium

    NARCIS (Netherlands)

    Constantinides, Alexander; Kerstens, Michiel N.; Dikkeschei, Bert D.; van Pelt, L. Joost; Tellis, Constantinos C.; Tselepis, Alexandros D.; Dullaart, Robin P. F.

    2012-01-01

    Eur J Clin Invest 2012; 42 (11): 12351243 Abstract Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel cardiovascular risk marker, which is predominantly complexed to apolipoprotein (apo) B-containing lipoproteins in human plasma. As increasing dietary sodium intake may decrease

  16. ISR-1 Seminar: Nuclear Cloud Lofting

    International Nuclear Information System (INIS)

    Walker, Andrew Charles

    2016-01-01

    This report goes into detail about motivation, background, lofting methodologies (empirical, parcel methods, Navier-Stokes), DELFIC Model, validation, DIORAMA integration, and has the following conclusions: A parcel methodology was applied to develop the DIORAMA cloud lofting module. It is based on the DELFIC model and treats the cloud as a homogenous unit. It solves the set of 8 ODEs for cloud properties. It outputs the time history of the cloud height, radius, and other parameters. The cloud lofting module was tuned with 54 test cases. An iterative brute force search was carried out to find the best fit tuning parameters. The best fit parameters yielded average cloud height errors of 12.9% and 10.3% for the bottom and top, respectively. This all allows for more accurate modeling of the propagation of delayed gamma rays in DIORAMA.

  17. 2-LP mode few-mode fiber amplifier employing ring-core erbium-doped fiber.

    Science.gov (United States)

    Ono, Hirotaka; Hosokawa, Tsukasa; Ichii, Kentaro; Matsuo, Shoichiro; Nasu, Hitoshi; Yamada, Makoto

    2015-10-19

    A fiber amplifier supporting 2 LP modes that employs a ring-core erbium-doped fiber (RC-EDF) is investigated to reduce differential modal gain (DMG). The inner and outer radii of the ring-core of the RC-EDF are clarified for 2-LP mode operation of the amplifier, and are optimized to reduce the DMG. It is shown that using the overlap integral between the erbium-doped core area and the signal power mode distribution is a good way to optimize the inner and outer radii of the ring-core of the RC-EDF and thus minimize the DMG. A fabricated RC-EDF and a constructed 2-LP mode EDFA are described and a small DMG of around 1 dB is realized for LP01, LP11 and LP21 pumping.

  18. Determining the group velocity dispersion by field analysis for the LP0X, LP1X, and LP2X mode groups independently of the fiber length: applications to step-index fibers

    DEFF Research Database (Denmark)

    Israelsen, Stine Møller; Usuga Castaneda, Mario A.; Rottwitt, Karsten

    2017-01-01

    By knowing the electric field distribution of a guided mode in an optical fiber, we are able to evaluate the group velocity dispersion in a weakly guiding step-index fiber for a pure mode in the LP0X, LP1X, and LP2X mode groups independently of the fiber length. We demonstrate the method numerica...

  19. LOFT uncertainty-analysis methodology

    International Nuclear Information System (INIS)

    Lassahn, G.D.

    1983-01-01

    The methodology used for uncertainty analyses of measurements in the Loss-of-Fluid Test (LOFT) nuclear-reactor-safety research program is described and compared with other methodologies established for performing uncertainty analyses

  20. LOFT uncertainty-analysis methodology

    International Nuclear Information System (INIS)

    Lassahn, G.D.

    1983-01-01

    The methodology used for uncertainty analyses of measurements in the Loss-of-Fluid Test (LOFT) nuclear reactor safety research program is described and compared with other methodologies established for performing uncertainty analyses

  1. Results and analysis of a loss-of-feedwater induced ATWS experiment in the LOFT Facility

    International Nuclear Information System (INIS)

    Grush, W.H.; Koizumi, Y.; Woerth, S.C.

    1983-01-01

    An anticipated transient without scram (ATWS), initiated by a loss of feedwater, was experimentally simulated in the Loss-of-Fluid Test (LOFT) pressurized water reactor (PWR). Primary system pressure was controlled using a two-position actuator relief valve to simulate a scaled power-operated relief valve (PORV) and safety relief valve (SRV) representative of those in a commercial PWR. Auxiliary feedwater injection was delayed during the experiment until the plant recovery phase where long-term shutdown was achieved by an operator-controlled plant recovery procedure without inserting the control rods. The system transient response predicted by the RELAP5/MOD1 computer code showed good agreement with the experimental data

  2. Atmospheric Propagation Modeling Indicates Homing Pigeons use Loft-Specific Infrasonic 'Map' Cues

    Science.gov (United States)

    Hagstrum, J. T.; Baker, L. M.; Spritzer, J. M.; McKenna, M. H.

    2011-12-01

    Pigeons (Columba livia) released at distant sites commonly depart in directions significantly off the actual homeward bearing. Such site-dependent deviations, or biases, for birds from a given loft are generally stable over time, but can also change from hour to hour, day to day, and year to year. At some release sites, birds consistently vanish in random directions and have longer flight times and lower return rates. Release sites characterized by frequent disorientation are not uncommon for pigeon lofts in both Europe and the USA. One such site is the Jersey Hill fire tower in upstate New York located ~120 km W of the Cornell loft in Ithaca. Cornell birds released at Jersey Hill between 1968 and 1987 almost always vanished randomly, although birds from other lofts had little difficulty orienting there. The results for one day, however, stand out: on August 13, 1969, Cornell birds released at Jersey Hill vanished consistently to the NE (r = 0.921; n=7) and returned home after normal flight times. Cornell pigeons released the next day again showed 'normal' behavior for the site and departed randomly. If, in fact, the birds are using acoustic cues to navigate, the long-term acoustic 'dead' zone we propose for Jersey Hill, due to prevailing atmospheric conditions, indicates that the cues are coming from a single, relatively restricted area, most likely surrounding the home loft. We have modeled the transmission of infrasonic waves, presumably coupled to the atmosphere from ocean-generated microseisms (0.14 Hz), between the Cornell loft and a number of release sites using HARPA (Hamiltonian Acoustic Ray-tracing Program for the Atmosphere) and rawinsonde data collected near Albany and Buffalo, NY. The HARPA modeling shows that acoustic signals from the Cornell loft reached Jersey Hill only on a few release days with unusual atmospheric conditions, including August 13, and were launched at angles less than ~2° above horizontal, most likely from steep-sided terrain in

  3. LOFT fuel rod pressure measurement

    International Nuclear Information System (INIS)

    Billeter, T.R.

    1979-01-01

    Pressure sensors selected for measuring fuel rod pressure within the LOFT reactor exhibited stable, repeatable operating characteristics during calibrations at temperatures up to 800 0 F and pressures to 2500 psig. All sensors have a nominal sensitivity of .5 millivolts per psi, decreasing monotonically with temperature. Output signal increases linearly with increasing pressure up to 2000 psig. For imposed slow and rapid temperature variations and for pressure applied during these tests, the sensor indicates a pressure at variance with the actual value by up to 15% of reading. However, the imposed temperature rates of change often exceeded the value of -10 0 F/sec. specified for LOFT. The series of tests in an autoclave permit creation of an environment most closely resembling sensor operating conditions within LOFT. For multiple blowdowns and for longtime durations the sensor continued to provide pressure-related output signals. For temperature rates up to -87 0 F/sec, the indicated pressure measurement error remained less than 13% of reading. Adverse effects caused by heating the 1/16 inch O.D. signal cable to 800 0 F contributed only insignificantly to the noted pressure measurement error

  4. The LOFT perspective on neutron star thermonuclear bursts

    DEFF Research Database (Denmark)

    in ’t Zand, J.J.M.; Altamirano, D.; Ballantyne, D. R.

    This is a White Paper in support of the mission concept of the Large Observatory for X-ray Timing (LOFT), proposed as a medium-sized ESA mission. We discuss the potential of LOFT for the study of thermonuclear X-ray bursts on accreting neutron stars. For a summary, we refer to the paper....

  5. LOFT - The large observatory for x-ray timing

    DEFF Research Database (Denmark)

    Feroci, M.; Den Herder, J.W.; Argan, A.

    2012-01-01

    The LOFT mission concept is one of four candidates selected by ESA for the M3 launch opportunity as Medium Size missions of the Cosmic Vision programme. The launch window is currently planned for between 2022 and 2024. LOFT is designed to exploit the diagnostics of rapid X-ray flux and spectral v...

  6. Defect analysis program for LOFT. Progress report, 1977

    International Nuclear Information System (INIS)

    Doyle, R.E.; Scoonover, T.M.

    1978-03-01

    In order to alleviate problems encountered while performing previous defect analyses on components of the LOFT system, regions of LOFT most likely to require defect analysis have been identified. A review of available documentation has been conducted to identify shapes, sizes, materials, and welding procedures and to compile mechanical property data. The LOFT Reactor Vessel Material Surveillance Program has also been reviewed, and a survey of available literature describing existing techniques for conducting elastic-plastic defect analysis was initiated. While large amounts of mechanical property data were obtained from the available documentation and the literature, much information was not available, especially for weld heat-affected zones. Therefore, a program of mechanical property testing is recommended for FY-78 as well as continued literature search. It is also recommended that fatigue-crack growth-rate data be sought from the literature and that evaluation of the various techniques of elastic-plastic defect analysis be continued. Review of additional regions of the LOFT system in the context of potential defect analysis will be conducted as time permits

  7. LOFT advanced control room operator diagnostic and display system (ODDS)

    International Nuclear Information System (INIS)

    Larsen, D.G.; Robb, T.C.

    1980-01-01

    The Loss-of-Fluid Test (LOFT) Reactor Facility in Idaho includes a highly instrumented nuclear reactor operated by the Department of Energy for the purpose of establishing nuclear safety requirements. The results of the development and installation into LOFT of an Operator Diagnostic and Display System (ODDS) are presented. The ODDS is a computer-based graphics display system centered around a PRIME 550 computer with several RAMTEK color graphic display units located within the control room and available to the reactor operators. Use of computer-based color graphics to aid the reactor operator is discussed. A detailed hardware description of the LOFT data system and the ODDS is presented. Methods and problems of backfitting the ODDS equipment into the LOFT plant are discussed

  8. The Science Payload of the LOFT Mission

    DEFF Research Database (Denmark)

    Feroci, Marco; den Herder, J.; van der Klis, M.

    The scientific payload onboard the Large Observatory For x-ray Timing mission (LOFT, see presentation by P. Ray et al. at this meeting) is composed of two instruments, the Large Area Detector (LAD, 10 m2 effective area in the primary energy range 2-30 keV, 1-deg collimated field of view) and the ...

  9. Stress analysis of the LOFT modular DTT flowmeter for LOCE transients (L1-5 and L2-4)

    International Nuclear Information System (INIS)

    Mosby, W.R.

    1978-01-01

    An analysis is presented of combined stresses in the LOFT Modular DTT for specified temperature gradients. All combined stress intensities are shown to stay within applicable allowable stress intensities. A fatigue analysis is also presented which indicates that the LOFT Modular DTT will withstand 70,000 blowdown cycles. The LOFT Modular DTT is shown to meet the Class 1 stress requirments. A stress analysis of the tab region of the newly designed MDTT tab-type shroud is included. This stress analysis shows that the Class 1 stress requirements are met by the tab-type MDTT shroud design and that this design imposes no fatigue life limitation on the MDTT

  10. Application of RELAP5/MOD3.1 code to the LOFT test L3-6

    International Nuclear Information System (INIS)

    Pylev, S.S.; Roginskaja, V.L.

    1998-02-01

    A calculation of LOFT Experiment L3-6, a small break equivalent to a 4-in diameter rupture in the cold leg of a four-loop commercial pressurized water reactor, has been performed to help validate RELAP5/MOD3.1 for this application. The version of the code to be used is SCDAP/RELAP5/MOD3.1.8d0. Three calculations were carried out in order to study the sensitivity to change break nozzle superheated discharge coefficient. Conducted comparative analysis of the LOFT L3-6 experiment shows on the whole a reasonable agreement between calculated data. Some discrepancies in the system pressure do not distort a picture of the transient. 6 refs

  11. Application of RELAP5/MOD3.1 code to the LOFT test L3-6

    Energy Technology Data Exchange (ETDEWEB)

    Pylev, S.S.; Roginskaja, V.L.

    1998-02-01

    A calculation of LOFT Experiment L3-6, a small break equivalent to a 4-in diameter rupture in the cold leg of a four-loop commercial pressurized water reactor, has been performed to help validate RELAP5/MOD3.1 for this application. The version of the code to be used is SCDAP/RELAP5/MOD3.1.8d0. Three calculations were carried out in order to study the sensitivity to change break nozzle superheated discharge coefficient. Conducted comparative analysis of the LOFT L3-6 experiment shows on the whole a reasonable agreement between calculated data. Some discrepancies in the system pressure do not distort a picture of the transient. 6 refs.

  12. Why does the agonist [18F]FP-TZTP bind preferentially to the M2 muscarinic receptor?

    International Nuclear Information System (INIS)

    Ravasi, L.; Kiesewetter, D.O.; Shimoji, K.; Lucignani, G.; Eckelman, W.C.

    2006-01-01

    Preferential binding of FP-TZTP at the M 2 receptor in vivo led to investigation of [ 18 F]FP-TZTP as a potential PET tracer for Alzheimer's disease, in which a substantial reduction of M 2 receptors has been observed in autopsy studies. We hereby investigated in vitro the FP-TZTP behavior to further elucidate the properties of FP-TZTP that lead to its M 2 selectivity. Chinese hamster ovarian cells expressing the five subtypes of human muscarinic receptor as well as the wild type were harvested in culture to assess equilibrium binding. Specific binding was calculated by subtraction of non-specific binding from total binding. Internal specific binding was calculated by subtraction of external specific binding from the total specific binding. Saturation assays were also performed to calculate B max , K i , and IC 50 . In addition, equilibrium binding and dissociation kinetic studies were performed on rat brain tissue. Selected regions of interest were drawn on the digital autoradiograms and [ 18 F]FP-TZTP off-rates were determined by measurement of the rate of release into a buffer solution of [ 18 F]FP-TZTP from slide-bound cells that had been preincubated with [ 18 F]FP-TZTP. At equilibrium in vitro, M 2 subtype selectivity of [ 18 F]FP-TZTP was not evident. We demonstrated that ATP-dependent mechanisms are not responsible for FP-TZTP M 2 selectivity. In vitro off-rate studies from rat brain tissue showed that the off-rate of FP-TZTP varied with the percentage of M 2 subtype in the tissue region. The slower dissociation kinetics of FP-TZTP from M 2 receptors compared with the four other muscarinic receptor subtypes may be a factor in its M 2 selectivity. (orig.)

  13. Validation of ozone profile retrievals derived from the OMPS LP version 2.5 algorithm against correlative satellite measurements

    Science.gov (United States)

    Kramarova, Natalya A.; Bhartia, Pawan K.; Jaross, Glen; Moy, Leslie; Xu, Philippe; Chen, Zhong; DeLand, Matthew; Froidevaux, Lucien; Livesey, Nathaniel; Degenstein, Douglas; Bourassa, Adam; Walker, Kaley A.; Sheese, Patrick

    2018-05-01

    The Limb Profiler (LP) is a part of the Ozone Mapping and Profiler Suite launched on board of the Suomi NPP satellite in October 2011. The LP measures solar radiation scattered from the atmospheric limb in ultraviolet and visible spectral ranges between the surface and 80 km. These measurements of scattered solar radiances allow for the retrieval of ozone profiles from cloud tops up to 55 km. The LP started operational observations in April 2012. In this study we evaluate more than 5.5 years of ozone profile measurements from the OMPS LP processed with the new NASA GSFC version 2.5 retrieval algorithm. We provide a brief description of the key changes that had been implemented in this new algorithm, including a pointing correction, new cloud height detection, explicit aerosol correction and a reduction of the number of wavelengths used in the retrievals. The OMPS LP ozone retrievals have been compared with independent satellite profile measurements obtained from the Aura Microwave Limb Sounder (MLS), Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) and Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS). We document observed biases and seasonal differences and evaluate the stability of the version 2.5 ozone record over 5.5 years. Our analysis indicates that the mean differences between LP and correlative measurements are well within required ±10 % between 18 and 42 km. In the upper stratosphere and lower mesosphere (> 43 km) LP tends to have a negative bias. We find larger biases in the lower stratosphere and upper troposphere, but LP ozone retrievals have significantly improved in version 2.5 compared to version 2 due to the implemented aerosol correction. In the northern high latitudes we observe larger biases between 20 and 32 km due to the remaining thermal sensitivity issue. Our analysis shows that LP ozone retrievals agree well with the correlative satellite observations in characterizing vertical, spatial and temporal

  14. LOFT pressurizer safety: relief valve reliability

    Energy Technology Data Exchange (ETDEWEB)

    Brown, E.S.

    1978-01-18

    The LOFT pressurizer self-actuating safety-relief valves are constructed to the present state-of-the-art and should have reliability equivalent to the valves in use on PWR plants in the U.S. There have been no NRC incident reports on valve failures to lift that would challenge the Technical Specification Safety Limit. Fourteen valves have been reported as lifting a few percentage points outside the +-1% Tech. Spec. surveillance tolerance (9 valves tested over and 5 valves tested under specification). There have been no incident reports on failures to reseat. The LOFT surveillance program for assuring reliability is equivalent to nuclear industry practice.

  15. LOFT pressurizer safety: relief valve reliability

    International Nuclear Information System (INIS)

    Brown, E.S.

    1978-01-01

    The LOFT pressurizer self-actuating safety-relief valves are constructed to the present state-of-the-art and should have reliability equivalent to the valves in use on PWR plants in the U.S. There have been no NRC incident reports on valve failures to lift that would challenge the Technical Specification Safety Limit. Fourteen valves have been reported as lifting a few percentage points outside the +-1% Tech. Spec. surveillance tolerance (9 valves tested over and 5 valves tested under specification). There have been no incident reports on failures to reseat. The LOFT surveillance program for assuring reliability is equivalent to nuclear industry practice

  16. FP plate-out and compound formation analysis in hot helium coolant of 600 MWt GTHTR300 system by FP concentration difference diffusion and aerosol-condensation mechanism

    International Nuclear Information System (INIS)

    Ishiyama, Shintaro

    2004-01-01

    To estimate FP deposition rate on the typical turbomachinary, including gas turbine of GTHTR300 and exposure dose limit at its maintenance, FP plate-out analysis was been carried out using FP compound formation theory and FP concentration controlled diffusion mechanism. As the results, following conclusions were derived; (1) It is found that the analysis data computed by the VICTORIA code with assumption of the correct thickness of reactive zone exhibits very good correlation with the experimental data obtained by simulated FP plate-out experiment. (2) 137 Cs, 110m Ag and 137 Cs (131+133) I compound are major fission products deposited on the surface of turbomachinery. (3) Deposition rates of major FPs on the surface of gas turbine blade and disk are (131+133) I> 137 Cs> 110m Ag. (4) Total dose rate and allowable work time at turbine of GTHTR300 are given as 19.2 mSv/h and 2.6 h by VICTORIA code analysis and these values are conservative than that given by simple code analysis. (author)

  17. Loft fire protection

    International Nuclear Information System (INIS)

    White, E.R.; Jensen, J.D.

    1980-01-01

    Quantified criteria that was developed and applied to provide in-depth fire protection for the Loss of Fluid Test (LOFT) Facility are presented. The presentation describes the evolution process that elevated the facility's fire protection from minimal to that required for a highly protected risk or improved risk. Explored are some infrequently used fire protection measures that are poorly understood outside the fire protection profession

  18. PHEBUS FP release analysis using a microstructure-based code

    International Nuclear Information System (INIS)

    Carlucci, L.N.

    1992-03-01

    The results of pre-test fission-product (FP) release analyses of the first two PHEBUS FP experiments, FPT0 and FPT1, indicate that the FREEDOM microstructure-based code predicts significant differences in both the timing and percent of gaseous FP releases for the two tests. To provide an indication of its predictive capability, FREEDOM was also used to model the high-burnup fuel tested in the Oak Ridge National Laboratory experiments VI-2 and VI-3. For these, the code was found to overpredict releases during the early stages of the tests and to underpredict releases during the later stages. The release kinetics in both tests were reasonably predicted, however. In view of the above, it is likely that the FREEDOM predictions of the final cumulative releases for the first two PHEBUS FP tests are lower-bound estimates. However, the significant difference in the predicted timing of initial releases for the two tests is felt to be indicative of what will occur. Therefore, this difference should be considered in the planning and conduct of the two tests, particularly aspects related to on-line measurements

  19. Lofts: habitações para além do contexto moderno Lofts: habitaciones más allá del contexto moderno Lofts: habitations for beyond the modern scene

    Directory of Open Access Journals (Sweden)

    Bruno Ricardo Vasconcelos

    2012-01-01

    Full Text Available Este artigo problematiza a habitação humana na contemporaneidade, tomando o loft como objeto de análise. Seu objetivo é dialogar, a partir de perspectivas críticas acerca das implicações que emergem da re-significação do espaço da casa, lócus das relações interpessoais contemporâneas. A partir de um referencial teórico que transita entre a psicanálise e a Sociologia, constata-se que as dinâmicas que se dão num contexto de transição, onde os modos de vida estão em metamorfose, assim como o seu contorno e seu substrato. E nesse contexto, o loft emerge como um símbolo da pós-modernidade, na transposição do espaço público para o privado, sendo um local onde tudo se vê e tudo se mostra, da liquidez das relações e da solidão.Este artículo problematiza la vivienda humana en la contemporaneidad, tomando el loft como objeto de análisis. Su objetivo es dialogar, desde perspectivas críticas acerca de las implicaciones que emergen de la resignificación del espacio de la casa, locus de las relaciones interpersonales contemporáneas. Desde un referencial teórico que transita entre el Psicoanálisis y la Sociología, se constata que las dinámicas que se dan en un contexto de transición, donde los modos de vida están en metamorfosis, así como su contorno y su substrato. Y en ese contexto, el loft emerge como un símbolo de la post modernidad, en la transposición del espacio público para el privado, siendo un lugar donde todo se ve y todo se muestra, de la liquidez de las relaciones y de la soledad.This article discusses the human habitation in contemporary times, taking the loft as an object of analysis. Its objective is to dialogue, parting from critical perspectives about the implications that emerges of re-signification of the house's space, locus of the interpersonal contemporary relationships. Using theorical references that moves towards Psychoanalysis and Sociology, it is observed that the dynamics which develops

  20. Analysis of results from a loss-of-offsite-power-initiated ATWS experiment in the LOFT Facility

    International Nuclear Information System (INIS)

    Varacalle, D.J.; Giri, A.M.; Koizumi, Y.; Koske, J.E.

    1983-01-01

    An anticipated transient without scram (ATWS), initiated by loss-of-offsite power, was experimentally simulated in the Loss-of-Fluid Test (LOFT) pressurized water reactor (PWR). Primary system pressure was controlled using a scaled safety relief valve (SRV) representative of those in a commercial PWR, while reactor power was reduced by moderator reactivity feedback in a natural circulation mode. The experiment showed that reactor power decreases more rapidly when the primary pumps are tripped in a loss-of-offsite-power ATWS than in a loss-of-feedwater induced ATWS when the primary pumps are left on. During the experiment, the SRV had sufficient relief capacity to control primary system pressure. Natural circulation was effective in removing core heat at high temperature, pressure, and core power. The system transient response predicted using the RELAPS/MOD1 computer code showed good agreement with the experimental data

  1. Validation of ozone profile retrievals derived from the OMPS LP version 2.5 algorithm against correlative satellite measurements

    Directory of Open Access Journals (Sweden)

    N. A. Kramarova

    2018-05-01

    Full Text Available The Limb Profiler (LP is a part of the Ozone Mapping and Profiler Suite launched on board of the Suomi NPP satellite in October 2011. The LP measures solar radiation scattered from the atmospheric limb in ultraviolet and visible spectral ranges between the surface and 80 km. These measurements of scattered solar radiances allow for the retrieval of ozone profiles from cloud tops up to 55 km. The LP started operational observations in April 2012. In this study we evaluate more than 5.5 years of ozone profile measurements from the OMPS LP processed with the new NASA GSFC version 2.5 retrieval algorithm. We provide a brief description of the key changes that had been implemented in this new algorithm, including a pointing correction, new cloud height detection, explicit aerosol correction and a reduction of the number of wavelengths used in the retrievals. The OMPS LP ozone retrievals have been compared with independent satellite profile measurements obtained from the Aura Microwave Limb Sounder (MLS, Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS and Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS. We document observed biases and seasonal differences and evaluate the stability of the version 2.5 ozone record over 5.5 years. Our analysis indicates that the mean differences between LP and correlative measurements are well within required ±10 % between 18 and 42 km. In the upper stratosphere and lower mesosphere (> 43 km LP tends to have a negative bias. We find larger biases in the lower stratosphere and upper troposphere, but LP ozone retrievals have significantly improved in version 2.5 compared to version 2 due to the implemented aerosol correction. In the northern high latitudes we observe larger biases between 20 and 32 km due to the remaining thermal sensitivity issue. Our analysis shows that LP ozone retrievals agree well with the correlative satellite observations in characterizing

  2. The LOFT (Large Observatory for X-ray Timing) background simulations

    DEFF Research Database (Denmark)

    Campana, R.; Feroci, M.; Del Monte, E.

    2012-01-01

    The Large Observatory For X-ray Timing (LOFT) is an innovative medium-class mission selected for an assessment phase in the framework of the ESA M3 Cosmic Vision call. LOFT is intended to answer fundamental questions about the behavior of matter in theh very strong gravitational and magnetic fields...

  3. Sensitivity analysis of LOFT L2-5 test calculations

    International Nuclear Information System (INIS)

    Prosek, Andrej

    2014-01-01

    The uncertainty quantification of best-estimate code predictions is typically accompanied by a sensitivity analysis, in which the influence of the individual contributors to uncertainty is determined. The objective of this study is to demonstrate the improved fast Fourier transform based method by signal mirroring (FFTBM-SM) for the sensitivity analysis. The sensitivity study was performed for the LOFT L2-5 test, which simulates the large break loss of coolant accident. There were 14 participants in the BEMUSE (Best Estimate Methods-Uncertainty and Sensitivity Evaluation) programme, each performing a reference calculation and 15 sensitivity runs of the LOFT L2-5 test. The important input parameters varied were break area, gap conductivity, fuel conductivity, decay power etc. For the influence of input parameters on the calculated results the FFTBM-SM was used. The only difference between FFTBM-SM and original FFTBM is that in the FFTBM-SM the signals are symmetrized to eliminate the edge effect (the so called edge is the difference between the first and last data point of one period of the signal) in calculating average amplitude. It is very important to eliminate unphysical contribution to the average amplitude, which is used as a figure of merit for input parameter influence on output parameters. The idea is to use reference calculation as 'experimental signal', 'sensitivity run' as 'calculated signal', and average amplitude as figure of merit for sensitivity instead for code accuracy. The larger is the average amplitude the larger is the influence of varied input parameter. The results show that with FFTBM-SM the analyst can get good picture of the contribution of the parameter variation to the results. They show when the input parameters are influential and how big is this influence. FFTBM-SM could be also used to quantify the influence of several parameter variations on the results. However, the influential parameters could not be

  4. Experiment data report for semiscale Mod-1 test S-06-4 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Gillins, R.L.; Sackett, K.E.; Coppin, C.E.

    1977-12-01

    Recorded test data are presented for Test S-06-4 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-4 was conducted from initial conditions of 15,653 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 100 percent of the maximum peak power density

  5. Experiment data report for semiscale Mod-1 test S-06-1 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

    1977-07-01

    Recorded test data are presented for Test S-06-1 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-1 was conducted from initial conditions of 15 568 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 30% of the maximum peak power density

  6. The collective bands of positive parity states in odd-A (fp) shell nuclei

    International Nuclear Information System (INIS)

    Ahalpara, D.P.

    1979-01-01

    The low-lying collective bands of positive parity states in (fp) shell nuclei are described in the deformed Hartree-Fock method by projecting states of definite angular momenta from 'the lowest energy intrinsic states in (sd)sup(-1)(fp)sup(n+1) configurations. The modified Kuo-Brown effective interaction for (fp) shell and modified surface delta interaction (MSDI) for a hole in (sd) shell with a particle in (fp) shell have been used. The collective bands of states are in general well reproduced by the effective interactions. The excitation energies of the band head states are however off by about one MeV. The calculated magnetic moments of the band head j = 3/2 + states are in reasonable agreement with experiment. Using effective charges esub(p) = 1.33 e and esub(n) = 0.64 e fairly good agreement is obtained for E(2) transitions. The hindered M(1) transition strengths are reproduced to the correct order, however they are slightly higher compared to the experiment. (author)

  7. Monitoring the Crab Nebula with LOFT

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2012-01-01

    From 2008-2010, the Crab Nebula was found to decline by 7% in the 15-50 keV band, consistently in Fermi GBM, INTEGRAL IBIS, SPI, and JEMX, RXTE PCA, and Swift BAT. From 2001-2010, the 15-50 keV flux from the Crab Nebula typically varied by about 3.5% per year. Analysis of RXTE PCA data suggests possible spectral variations correlated with the flux variations. I will present estimates of the LOFT sensitivity to these variations. Prior to 2001 and since 2010, the observed flux variations have been much smaller. Monitoring the Crab with the LOFT WFM and LAD will provide precise measurements of flux variations in the Crab Nebula if it undergoes a similarly active episode.

  8. Variance components and selection response for feather-pecking behavior in laying hens.

    Science.gov (United States)

    Su, G; Kjaer, J B; Sørensen, P

    2005-01-01

    Variance components and selection response for feather pecking behavior were studied by analyzing the data from a divergent selection experiment. An investigation indicated that a Box-Cox transformation with power lambda = -0.2 made the data approximately normally distributed and gave the best fit for the model. Variance components and selection response were estimated using Bayesian analysis with Gibbs sampling technique. The total variation was rather large for the investigated traits in both the low feather-pecking line (LP) and the high feather-pecking line (HP). Based on the mean of marginal posterior distribution, in the Box-Cox transformed scale, heritability for number of feather pecking bouts (FP bouts) was 0.174 in line LP and 0.139 in line HP. For number of feather-pecking pecks (FP pecks), heritability was 0.139 in line LP and 0.105 in line HP. No full-sib group effect and observation pen effect were found in the 2 traits. After 4 generations of selection, the total response for number of FP bouts in the transformed scale was 58 and 74% of the mean of the first generation in line LP and line HP, respectively. The total response for number of FP pecks was 47 and 46% of the mean of the first generation in line LP and line HP, respectively. The variance components and the realized selection response together suggest that genetic selection can be effective in minimizing FP behavior. This would be expected to reduce one of the major welfare problems in laying hens.

  9. Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status.

    Directory of Open Access Journals (Sweden)

    Jean Kyung Paik

    Full Text Available BACKGROUND: This study aimed to determine the association of lipoprotein-associated phospholipase A(2 (Lp-PLA(2 activity in circulation and peripheral blood mononuclear cells (PBMCs with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA(2 activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: Eighty postmenopausal women (53.0±4.05 yr and 96 premenopausal women (39.7±9.25 yr participated in this study. Lp-PLA(2 activities, interleukin (IL-6, tumor necrosis factor (TNF-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA(2 activity positively correlated with Lp-PLA(2 activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA(2 activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L, a significant increase in Lp-PLA(2 activity in the plasma but not the PBMCs was found in the high ox-LDL subgroup. Plasma Lp-PLA(2 activity positively correlated with unstimulated PBMC Lp-PLA(2 activity in the low ox-LDL subgroup (r = 0.627, P<0.001, whereas in the high ox-LDL circulating Lp-PLA(2 activity positively correlated with plasma ox-LDL (r = 0.390, P = 0.014 but not with Lp-PLA(2 activity in PBMCs. CONCLUSIONS/SIGNIFICANCE: The lack of relation between circulating Lp-PLA(2 activity and Lp-PLA(2 activity in PBMCs was found in postmenopausal women with high ox-LDL. This may indicate other sources of circulating Lp-PLA(2 activity except PBMC in postmenopausal women

  10. Experiment data report for semiscale Mod-1 Test S-06-5. (LOFT counterpart test)

    International Nuclear Information System (INIS)

    1977-06-01

    Recorded test data are presented for Test S-06-5 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-5 was conducted from initial conditions of 2272 psia and 536 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold legs of the intact and broken loops to simulate emergency core coolant injection in a PWR. The purpose of Test S-06-5 was to assess the influence of the break nozzle geometry on core thermal and system response and on the subcooled and low quality mass flow rates at the break locations

  11. Comparison of LOFT zero power physics testing measurement results with predicted values

    International Nuclear Information System (INIS)

    Rushton, B.L.; Howe, T.M.

    1978-01-01

    The results of zero power physics testing measurements in LOFT have been evaluated to assess the adequacy of the physics data used in the safety analyses performed for the LOFT FSAR and Technical Specifications. Comparisons of measured data with computed data were made for control rod worths, temperature coefficients, boron worths, and pressure coefficients. Measured boron concentrations at exact critical points were compared with predicted concentrations. Based on these comparisons, the reactivity parameter values used in the LOFT safety analyses were assessed for conservatism

  12. The Phebus FP thermal-hydraulic analysis with Melcor

    Energy Technology Data Exchange (ETDEWEB)

    Akgane, Kikuo; Kiso, Yoshihiro [Nuclear Power Engineering Corporation, Tokyo (Japan); Fukahori, Takanori [Hitachi Engineering Company, Ltd., Hitachi-shi Ibaraki-ken (Japan); Yoshino, Mamoru [Nuclear Engineering Ltd., Tosabori Nishi-ku (Japan)

    1995-09-01

    The severe accident analysis code MELCOR, version 1.8.2, has been applied for thermal-hydraulic pre-test analysis of the first test of the Phebus FP program (test FPT-0) to study the best test parameters and the applicability of the code. The Phebus FP program is an in-pile test program which has been planned by the French Commissariate a L`Energie Atomique and the Commission of the European Union. The experiments are being conducted by an international collaboration to study the release and transport of fission products (FPs) under conditions assumed to be the most representative of those that would occur in a severe accident. The Phebus FP test apparatus simulates a test bundle of an in-pile section, the circuit including the steam generator U-tubes and the containment. The FPT-0 test was designed to simulate the heat-up and subsequent fuel bundle degradation after a loss of coolant severe accident, using fresh fuel. Two options for fuel degradation models in MELCOR have been applied to fuel degradation behavior. the first model assumes that fuel debris will be formed immediately after the fuel support fails by cladding relocation due to the candling process. The other is the uncollapsed bare fuel pellets option, in which the fuel pellets remain standing in a columnar shape until the fuel reaches its melting point, even if the cladding has been relocated by candling. The thermal-hydraulic behaviors in the circuit and containment of Phebus FP are discussed herein. Flow velocities in the Phebus FP circuit are high in order to produce turbulent flow in a small diameter test pipe. The MELCOR calculation has shown that the length of the hot leg and steam generator are adequate to attain steam temperatures or 700{degrees}C and 150{degrees}C in the respective outlets. The containment atmosphere temperature and humidity derived by once through integral system calculation show that objective test conditions would be satisfied in the Phebus FP experiment.

  13. The Phebus FP thermal-hydraulic analysis with Melcor

    International Nuclear Information System (INIS)

    Akgane, Kikuo; Kiso, Yoshihiro; Fukahori, Takanori; Yoshino, Mamoru

    1995-01-01

    The severe accident analysis code MELCOR, version 1.8.2, has been applied for thermal-hydraulic pre-test analysis of the first test of the Phebus FP program (test FPT-0) to study the best test parameters and the applicability of the code. The Phebus FP program is an in-pile test program which has been planned by the French Commissariate a L'Energie Atomique and the Commission of the European Union. The experiments are being conducted by an international collaboration to study the release and transport of fission products (FPs) under conditions assumed to be the most representative of those that would occur in a severe accident. The Phebus FP test apparatus simulates a test bundle of an in-pile section, the circuit including the steam generator U-tubes and the containment. The FPT-0 test was designed to simulate the heat-up and subsequent fuel bundle degradation after a loss of coolant severe accident, using fresh fuel. Two options for fuel degradation models in MELCOR have been applied to fuel degradation behavior. the first model assumes that fuel debris will be formed immediately after the fuel support fails by cladding relocation due to the candling process. The other is the uncollapsed bare fuel pellets option, in which the fuel pellets remain standing in a columnar shape until the fuel reaches its melting point, even if the cladding has been relocated by candling. The thermal-hydraulic behaviors in the circuit and containment of Phebus FP are discussed herein. Flow velocities in the Phebus FP circuit are high in order to produce turbulent flow in a small diameter test pipe. The MELCOR calculation has shown that the length of the hot leg and steam generator are adequate to attain steam temperatures or 700 degrees C and 150 degrees C in the respective outlets. The containment atmosphere temperature and humidity derived by once through integral system calculation show that objective test conditions would be satisfied in the Phebus FP experiment

  14. Modulus, Strength and Thermal Exposure Studies of FP-Al2O3/Aluminum and FP-Al2O3/Magnesium Composites.

    Science.gov (United States)

    1981-01-01

    for the ~AUG18IS~ 1W Symposium on Comites and Advanced Materials*M sponsored by the American Ceramic Society Coco Beach, Florida, January 18424, 1981E...properties of cFP-A203 fiber reinforced composites prepared by liquid metal infiltration f a techniques. The first approach was the incorporation of a...coated FP-A1203 fibers in the composites. This coating is readily wet by molten aluminum and permitted the use of more conventional aluminum alloys

  15. Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics.

    Science.gov (United States)

    Fentoğlu, Özlem; Kirzioğlu, Fatma Yeşim; Tözüm Bulut, Memduha; Kurgan, Şivge; Koçak, Havva; Sütcü, Recep; Kale Köroğlu, Banu; Günhan, Meral

    2015-01-01

    To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). At the baseline, patients in the HS group had a higher percentage of bleeding on probing than those in the C and HD groups. Hyperlipidaemics had higher serum triglyceride levels than the control group at 2MPT compared to the baseline. At 2MPT, the levels of Lp-PLA2 in the HS group were significantly higher compared to the baseline and 1WPT. There were no statistically significant differences in CRP levels between study periods for all groups. The periodontal treatment may affect the inflammatory control of hyperlipidaemic patients with periodontitis via increased Lp-PLA2 levels and severity of the impaired lipid metabolism. These findings may be important regarding the therapeutic strategies for hyperlipidaemics with periodontitis.

  16. Special LOFT features for improved monitoring and survival of LOCA transients

    International Nuclear Information System (INIS)

    Goodrich, L.D.; Leach, L.P.; Klingler, T.B.; Morrow, J.C.; Phoenix, W.C.; Satterwhite, D.G.; Sumpter, K.C.; Rouhani, S.Z.; Welland, H.J.

    1980-01-01

    LOFT is designed to monitor and survive Loss-Of-Coolant-Accidents (LOCAs). This report presents the primary design difference from LPWRs that were required to accomplish this. These design differences may be of interest to the nuclear power generator industry. This report should be revised semi-annually or as developments in the LOFT Program require

  17. LOFT facility PSS experiments: analysis of wet well vertical loads resulting from transient initiation

    International Nuclear Information System (INIS)

    Berta, V.T.

    1977-05-01

    Fourteen experiments on the Loss-of-Fluid Test (LOFT) facility pressure suppression system (PSS) are analyzed in relation to the vertical load generated on the suppression tank in the first 0.5 sec of the transient. Variations in principle parameters affecting the generation of vertical loads were included in the experiments. The internal and external vent submergences are identified from the analysis as being parameters which are first order in influencing the magnitude of the vertical load. These parameters are geometric in nature and depend only on PSS design. Physical parameters of total energy input and rate of energy input to the dry well, which influence the dry well pressurization, also are identified as being first order in influencing the magnitude of the vertical loads. The vertical load magnitude is a direct function of these geometric and physical parameters. The analysis indicates that a small value in any one of the parameters will cause the vertical load to be small and to have little dependence on the magnitude of the other parameters. In addition, the phenomena of nonuniform nonsynchronized vent inlet pressures, which have origins that are either geometric, physical, or a combination of both, act as a significant vertical load reduction mechanism

  18. Learning to perceive and recognize a second language: the L2LP model revised.

    Science.gov (United States)

    van Leussen, Jan-Willem; Escudero, Paola

    2015-01-01

    We present a test of a revised version of the Second Language Linguistic Perception (L2LP) model, a computational model of the acquisition of second language (L2) speech perception and recognition. The model draws on phonetic, phonological, and psycholinguistic constructs to explain a number of L2 learning scenarios. However, a recent computational implementation failed to validate a theoretical proposal for a learning scenario where the L2 has less phonemic categories than the native language (L1) along a given acoustic continuum. According to the L2LP, learners faced with this learning scenario must not only shift their old L1 phoneme boundaries but also reduce the number of categories employed in perception. Our proposed revision to L2LP successfully accounts for this updating in the number of perceptual categories as a process driven by the meaning of lexical items, rather than by the learners' awareness of the number and type of phonemes that are relevant in their new language, as the previous version of L2LP assumed. Results of our simulations show that meaning-driven learning correctly predicts the developmental path of L2 phoneme perception seen in empirical studies. Additionally, and to contribute to a long-standing debate in psycholinguistics, we test two versions of the model, with the stages of phonemic perception and lexical recognition being either sequential or interactive. Both versions succeed in learning to recognize minimal pairs in the new L2, but make diverging predictions on learners' resulting phonological representations. In sum, the proposed revision to the L2LP model contributes to our understanding of L2 acquisition, with implications for speech processing in general.

  19. Simulation of LOFT anticipated-transient experiments L6-1, L6-2, and L6-3 using TRAC-PF1/MOD1

    International Nuclear Information System (INIS)

    Sahota, M.S.

    1984-01-01

    Anticipated-transient experiments L6-1, L6-2, and L6-3, performed at the Loss-of-fluid Test (LOFT) facility, are analyzed using the latest released version of the Transient Reactor Analysis Code (TRAC-PF1/MOD1). The results are used to assess TRAC-PF1/MOD1 trip and control capabilities, and predictions of thermal-hydraulic phenomena during slow transients. Test L6-1 simulated a loss-of-stream load in a large pressurized-water reactor (PWR), and was initiated by closing the main steam-flow control valve (MSFCV) at its maximum rate, which reduced the heat removal from the secondary-coolant system and increased the primary-coolant system pressure that initiated a reactor scram. Test L6-2 simulated a loss-of-primary coolant flow in a large PWR, and was initiated by tripping the power to the primary-coolant pumps (PCPs) allowing the pumps to coast down. The reduced primary-coolant flow caused a reactor scram. Test L6-3 simulated an excessive-load increase incident in a large PWR, and was initiated by opening the MSFCV at its maximum rate, which increased the heat removal from the secondary-coolant system and decreased the primary-coolant system pressure that initiated a reactor scram. The TRAC calculations accurately predict most test events. The test data and the calculated results for most parameters of interest also agree well

  20. Core-power and decay-time limits for disabled automatic-actuation of LOFT ECCS

    International Nuclear Information System (INIS)

    Hanson, G.H.

    1978-01-01

    The Emergency Core Cooling System (ECCS) for the LOFT reactor may need to be disabled for modifications or repairs of hardware or instrumentation or for component testing during periods when the reactor system is hot and pressurized, or it may be desirable to enable the ECCS to be disabled without the necessity of cooling down and depressurizing the reactor. LTR 113-47 has shown that the LOFT ECCS can be safely bypassed or disabled when the total core power does not exceed 25 kW. A modified policy involves disabling the automatic actuation of the LOFT ECCS, but still retaining the manual activation capability. Disabling of the automatic actuation can be safely utilized, without subjecting the fuel cladding to unacceptable temperatures, when the LOFT power decays to 70 kW; this power level permits a maximum delay of 20 minutes following a LOCA for the manual actuation of ECCS

  1. Bibliometric performance analysis of publications from Danish researchers linked to FP6 and FP7

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg; Ryan, Thomas Kjeldager

    2015-01-01

    This chapter presents an analysis29 of the impact of Danish scientific publications that were the result of FP6 or FP7 funding. The purpose is to gain an insight into the scientific impact researchers can achieve when participating in FP6 and FP7. In order to look at impact we have identified cit...... Foundation (DNRF) and the Danish Council for Independent Research (DFF). Finally the analyses also explore the impact at the level of programme themes under FP6 and FP7....

  2. Thermal analysis of LOFT modular DTT for LOCE transient

    International Nuclear Information System (INIS)

    Martin, C.M.

    1978-01-01

    A thermal analysis was performed on the LOFT modular drag-disc turbine transducer (MDTT) modular assembly. The purpose of this analysis was to determine the maximum temperature difference between the MDTT shroud and end cap during a LOCE. This temperature difference is needed for stress analysis of the MDTT endcap to fairing welds. The thermal analysis was done using TRIPLE, a three dimensional finite element code. A three dimensional model of the MDTT was made and transient temperature solutions were found for the different MDTT locations. The fluid temperature transients used for the solutions at all locations were from RELAP4 predictions of the LOFT L2-4 test which is considered the most severe temperature transient. Results of these calculations show the maximum temperature difference is 92 0 C (165 0 F) and occurs in the intact loop cold leg. This value and those found at other locations, are evaluated from the best available RELAP predicted temperatures during a nuclear LOCE

  3. Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study.

    Science.gov (United States)

    Siddiqui, Moneeza K; Kennedy, Gwen; Carr, Fiona; Doney, Alexander S F; Pearson, Ewan R; Morris, Andrew D; Johnson, Toby; McLaughlin, Megan M; Williams, Rachel E; Palmer, Colin N A

    2018-06-01

    The aim of the study was to examine the association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) activity levels and incident diabetic retinopathy and change in retinopathy grade. This was a cohort study of diabetic participants with serum collected at baseline and routinely collected diabetic retinal screening data. Participants with type 2 diabetes from the GoDARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) cohort were used. This cohort is composed of individuals of white Scottish ancestry from the Tayside region of Scotland. Survival analysis accounting for informative censoring by modelling death as a competing risk was performed for the development of incident diabetic retinopathy from a disease-free state in a 3 year follow-up period (n = 1364) by stratified Lp-PLA 2 activity levels (in quartiles). The same analysis was performed for transitions to more severe grades. The hazard of developing incident diabetic retinopathy was 2.08 times higher (95% CI 1.64, 2.63) for the highest quartile of Lp-PLA 2 activity compared with the lowest. Higher Lp-PLA 2 activity levels were associated with a significantly increased risk for transitions to all grades. The hazards of developing observable (or more severe) and referable (or more severe) retinopathy were 2.82 (95% CI 1.71, 4.65) and 1.87 (95% CI 1.26, 2.77) times higher for the highest quartile of Lp-PLA 2 activity compared with the lowest, respectively. Higher Lp-PLA 2 levels are associated with increased risk of death and the development of incident diabetic retinopathy, as well as transitions to more severe grades of diabetic retinopathy. These associations are independent of calculated LDL-cholesterol and other traditional risk factors. Further, this biomarker study shows that the association is temporally sensitive to the proximity of the event to measurement of Lp-PLA 2.

  4. LOFT integral test system final safety analysis report

    International Nuclear Information System (INIS)

    1974-03-01

    Safety analyses are presented for the following LOFT Reactor systems: engineering safety features; support buildings and facilities; instrumentation and controls; electrical systems; and auxiliary systems. (JWR)

  5. Genome-wide association study of Lp-PLA(2 activity and mass in the Framingham Heart Study.

    Directory of Open Access Journals (Sweden)

    Sunil Suchindran

    2010-04-01

    Full Text Available Lipoprotein-associated phospholipase A(2 (Lp-PLA(2 is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2 activity and mass in 6,668 Caucasian subjects from the population-based Framingham Heart Study. Clinical data and genotypes from the Affymetrix 550K SNP array were obtained from the open-access Framingham SHARe project. Each polymorphism that passed quality control was tested for associations with Lp-PLA(2 activity and mass using linear mixed models implemented in the R statistical package, accounting for familial correlations, and controlling for age, sex, smoking, lipid-lowering-medication use, and cohort. For Lp-PLA(2 activity, polymorphisms at four independent loci reached genome-wide significance, including the APOE/APOC1 region on chromosome 19 (p = 6 x 10(-24; CELSR2/PSRC1 on chromosome 1 (p = 3 x 10(-15; SCARB1 on chromosome 12 (p = 1x10(-8 and ZNF259/BUD13 in the APOA5/APOA1 gene region on chromosome 11 (p = 4 x 10(-8. All of these remained significant after accounting for associations with LDL cholesterol, HDL cholesterol, or triglycerides. For Lp-PLA(2 mass, 12 SNPs achieved genome-wide significance, all clustering in a region on chromosome 6p12.3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2 activity and mass.

  6. Quantification of Azospirillum brasilense FP2 Bacteria in Wheat Roots by Strain-Specific Quantitative PCR.

    Science.gov (United States)

    Stets, Maria Isabel; Alqueres, Sylvia Maria Campbell; Souza, Emanuel Maltempi; Pedrosa, Fábio de Oliveira; Schmid, Michael; Hartmann, Anton; Cruz, Leonardo Magalhães

    2015-10-01

    Azospirillum is a rhizobacterial genus containing plant growth-promoting species associated with different crops worldwide. Azospirillum brasilense strains exhibit a growth-promoting effect by means of phytohormone production and possibly by N2 fixation. However, one of the most important factors for achieving an increase in crop yield by plant growth-promoting rhizobacteria is the survival of the inoculant in the rhizosphere, which is not always achieved. The objective of this study was to develop quantitative PCR protocols for the strain-specific quantification of A. brasilense FP2. A novel approach was applied to identify strain-specific DNA sequences based on a comparison of the genomic sequences within the same species. The draft genome sequences of A. brasilense FP2 and Sp245 were aligned, and FP2-specific regions were filtered and checked for other possible matches in public databases. Strain-specific regions were then selected to design and evaluate strain-specific primer pairs. The primer pairs AzoR2.1, AzoR2.2, AzoR5.1, AzoR5.2, and AzoR5.3 were specific for the A. brasilense FP2 strain. These primer pairs were used to monitor quantitatively the population of A. brasilense in wheat roots under sterile and nonsterile growth conditions. In addition, coinoculations with other plant growth-promoting bacteria in wheat were performed under nonsterile conditions. The results showed that A. brasilense FP2 inoculated into wheat roots is highly competitive and achieves high cell numbers (∼10(7) CFU/g [fresh weight] of root) in the rhizosphere even under nonsterile conditions and when coinoculated with other rhizobacteria, maintaining the population at rather stable levels for at least up to 13 days after inoculation. The strategy used here can be applied to other organisms whose genome sequences are available. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  7. LOFT differential pressure uncertainty analysis

    International Nuclear Information System (INIS)

    Evans, R.P.; Biladeau, G.L.; Quinn, P.A.

    1977-03-01

    A performance analysis of the LOFT differential pressure (ΔP) measurement is presented. Along with completed descriptions of test programs and theoretical studies that have been conducted on the ΔP, specific sources of measurement uncertainty are identified, quantified, and combined to provide an assessment of the ability of this measurement to satisfy the SDD 1.4.1C (June 1975) requirement of measurement of differential pressure

  8. An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP

    International Nuclear Information System (INIS)

    Oosten, Erik M. van; Wilson, Alan A.; Stephenson, Karin A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Yudin, Andrei K.; Houle, Sylvain; Vasdev, Neil

    2009-01-01

    The radioligand 3-(4-(3-[ 18 F]fluoropropylthio)-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5, 6-tetrahydropyridine ([ 18 F]FP-TZTP) is an agonist with specificity towards subtype 2 of muscarinic acetylcholine (M2) receptors. It is currently the only radiotracer available for imaging M2 receptors in human subjects with positron emission tomography. The present study reports on an improved method for the synthesis of [ 18 F]FP-TZTP, automated using a GE TRACERlab TM FX FN radiosynthesis module. A key facet was the use of a new precursor, 3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio) propyl 4-methylbenzenesulfonate. The precursor was fluorinated via nucleophilic displacement of the tosyloxy group by potassium cryptand [ 18 F]fluoride (K[ 18 F]/K 222 ) in CH 3 CN at 80 deg. C for 5 min, and purified by HPLC. Formulated [ 18 F]FP-TZTP was prepared in an uncorrected radiochemical yield of 29±4%, with a specific activity of 138±41 GBq/μmol (3732±1109 mCi/μmol) at the end of synthesis (35 min; n=3). This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported

  9. 75 FR 39680 - Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid...

    Science.gov (United States)

    2010-07-12

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-44-000; Docket No. PR10-46-000; Docket No. PR10-48- 000; Docket No. PR10-49-000; Docket No. PR10-50-000] Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid Continent Market Center, L.L.C...

  10. Metabolism of 123I-FP-CIT in humans

    International Nuclear Information System (INIS)

    Tanaka, Akihiro; Okano, Kyoko; Tamagami, Hiroshi

    1999-01-01

    The metabolism of N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane ( 123 I) ( 123 I-FP-CIT) in healthy humans was studied. Plasma and urine samples, obtained after i.v. administration of 123 I-FP-CIT, were analyzed using the two-dimensional thin-layer chromatography technique. Eleven radiochemical components were detected in both plasma and urine, and four of them were the parent 123 I-FP-CIT and its metabolites, N-(3-fluoropropyl)-2β-carboxy-3β-(4-iodophenyl)nortropane ( 123 I) ( 123 I-acid), 2β-carboxy-3β-(4-iodophenyl)nortropane ( 123 I) ( 123 I-nor-acid) and 2β-carbomethoxy-3β-(4-iodophenyl)nortropane ( 123 I) ( 123 I-nor-CIT). These four identified radiochemical components occupied about 80% or more in ratio of the radiochemical components in the plasma and urine. In the metabolites of 123 I-FP-CIT, the high polar metabolites- 123 I-acid and 123 I-nor-acid-were found to be the major components, while lipophilic 123 I-nor-CIT was a minor component. Free iodide ( 123 I - ) was not found in the plasma or urine. Thus, the main metabolic reactions which 123 I-FP-CIT undergoes in humans seem to be hydrolysis of the ester bond and N-dealkylation. In vivo deiodination of 123 I-FP-CIT was found to be minimum. Current results suggest that the metabolites of 123 I-FP-CIT hardly influence evaluation of the dopamine transporter in the human brain. (author)

  11. Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity.

    Science.gov (United States)

    Kaneko, Mika K; Yamada, Shinji; Nakamura, Takuro; Abe, Shinji; Nishioka, Yasuhiko; Kunita, Akiko; Fukayama, Masashi; Fujii, Yuki; Ogasawara, Satoshi; Kato, Yukinari

    2017-04-01

    Human podoplanin (hPDPN), a platelet aggregation-inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C-type lectin-like receptor 2 (CLEC-2). The overexpression of hPDPN is involved in invasion and metastasis. Anti-hPDPN monoclonal antibodies (mAbs) such as NZ-1 have shown antitumor and antimetastatic activities by binding to the platelet aggregation-stimulating (PLAG) domain of hPDPN. Recently, we developed a novel mouse anti-hPDPN mAb, LpMab-2, using the cancer-specific mAb (CasMab) technology. In this study we developed chLpMab-2, a human-mouse chimeric anti-hPDPN antibody, derived from LpMab-2. chLpMab-2 was produced using fucosyltransferase 8-knockout (KO) Chinese hamster ovary (CHO)-S cell lines. By flow cytometry, chLpMab-2 reacted with hPDPN-expressing cancer cell lines including glioblastomas, mesotheliomas, and lung cancers. However, it showed low reaction with normal cell lines such as lymphatic endothelial and renal epithelial cells. Moreover, chLpMab-2 exhibited high antibody-dependent cellular cytotoxicity (ADCC) against PDPN-expressing cells, despite its low complement-dependent cytotoxicity. Furthermore, treatment with chLpMab-2 abolished tumor growth in xenograft models of CHO/hPDPN, indicating that chLpMab-2 suppressed tumor development via ADCC. In conclusion, chLpMab-2 could be useful as a novel antibody-based therapy against hPDPN-expressing tumors. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  12. The LOFT wide field monitor simulator

    DEFF Research Database (Denmark)

    Donnarumma, I.; Evangelista, Y.; Campana, R.

    2012-01-01

    We present the simulator we developed for the Wide Field Monitor (WFM) aboard the Large Observatory For Xray Timing (LOFT) mission, one of the four ESA M3 candidate missions considered for launch in the 2022–2024 timeframe. The WFM is designed to cover a large FoV in the same bandpass as the Large...

  13. Large Observatory for x-ray Timing (LOFT-P): a Probe-class mission concept study

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Ray, Paul S.; Chakrabarty, Deepto; Feroci, Marco; Alvarez, Laura; Baysinger, Michael; Becker, Chris; Bozzo, Enrico; Brandt, Soren; Carson, Billy; Chapman, Jack; Dominguez, Alexandra; Fabisinski, Leo; Gangl, Bert; Garcia, Jay; Griffith, Christopher; Hernanz, Margarita; Hickman, Robert; Hopkins, Randall; Hui, Michelle; Ingram, Luster; Jenke, Peter; Korpela, Seppo; Maccarone, Tom; Michalska, Malgorzata; Pohl, Martin; Santangelo, Andrea; Schanne, Stephane; Schnell, Andrew; Stella, Luigi; van der Klis, Michiel; Watts, Anna; Winter, Berend; Zane, Silvia

    2016-07-01

    LOFT-P is a mission concept for a NASA Astrophysics Probe-Class (matter? What are the effects of strong gravity on matter spiraling into black holes? It would be optimized for sub-millisecond timing of bright Galactic X-ray sources including X-ray bursters, black hole binaries, and magnetars to study phenomena at the natural timescales of neutron star surfaces and black hole event horizons and to measure mass and spin of black holes. These measurements are synergistic to imaging and high-resolution spectroscopy instruments, addressing much smaller distance scales than are possible without very long baseline X-ray interferometry, and using complementary techniques to address the geometry and dynamics of emission regions. LOFT-P would have an effective area of >6 m2, > 10x that of the highly successful Rossi X-ray Timing Explorer (RXTE). A sky monitor (2-50 keV) acts as a trigger for pointed observations, providing high duty cycle, high time resolution monitoring of the X-ray sky with 20 times the sensitivity of the RXTE All-Sky Monitor, enabling multi-wavelength and multimessenger studies. A probe-class mission concept would employ lightweight collimator technology and large-area solid-state detectors, segmented into pixels or strips, technologies which have been recently greatly advanced during the ESA M3 Phase A study of LOFT. Given the large community interested in LOFT (>800 supporters*, the scientific productivity of this mission is expected to be very high, similar to or greater than RXTE ( 2000 refereed publications). We describe the results of a study, recently completed by the MSFC Advanced Concepts Office, that demonstrates that such a mission is feasible within a NASA probe-class mission budget.

  14. Present status and plans of JENDL FP data evaluation project

    International Nuclear Information System (INIS)

    Kawano, Toshihiko

    2003-01-01

    The Fission Product (FP) data evaluation is one of the key issues for the next revision of JENDL, since many data were carried over from JENDL-3.2 to 3.3. The new FP Working Group (FPWG) was organized in the Japanese Nuclear Data Committee (JNDC) to perform new evaluations of FP data for JENDL. In the present review of FP data evaluation, we show the history and current status of FP nuclear data, requirements of FP data, new measurements, the international cooperation, and the future plans toward the new JENDL. (author)

  15. The importance of age and statin therapy in the interpretation of Lp-PLA(2) in ACS patients, and relation to CRP.

    Science.gov (United States)

    Franeková, J; Kettner, J; Kubíček, Z; Jabor, A

    2015-01-01

    C-reactive protein (CRP) is a marker of arterial inflammation while lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is related to plaque instability. The aim of this study was to evaluate the correlation between the risk of unstable plaque presenting as acute coronary syndrome (ACS) and Lp-PLA(2), and to assess the influence of statins on interpretation of Lp-PLA(2). A total of 362 consecutive patients presenting to the emergency department (ED) with acute chest pain suggestive of ACS were evaluated by cardiologists as STEMI, NSTEMI, or unstable angina, and non-ACS. Serum biomarkers measured on admission: troponin I, C-reactive protein (Abbott), and Lp-PLA(2) (DiaDexus). Four groups were defined according to the final diagnosis and history of statin medication: ACS/statin-; ACS/statin+; non-ACS/statin-; non-ACS/statin+. Lp-PLA(2) was highest in ACS/statin- group; statins decreased Lp-PLA(2) both in ACS and non-ACS of about 20 %. Lp-PLA(2) was higher in ACS patients in comparison with non-ACS patients group without respect to statin therapy (pPLA(2) predicted worse outcome (in terms of acute coronary syndrome) effectively in patients up to 62 years; limited prediction was found in older patients. C-reactive protein (CRP) failed to discriminate four groups of patients. Statin therapy and age should be taken into consideration while interpreting Lp-PLA(2) concentrations and lower cut-off values should be used for statin-treated persons.

  16. [{sup 18}F]{beta}-CIT-FP is superior to [{sup 11}C]{beta}-CIT-FP for quantitation of the dopamine transporter

    Energy Technology Data Exchange (ETDEWEB)

    Lundkvist, Camilla; Halldin, Christer; Ginovart, Nathalie; Swahn, Carl-Gunnar; Farde, Lars

    1997-10-01

    {beta}-CIT-FP [N-(3-fluoropropyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)nortropane] is a cocaine analogue with high affinity for the dopamine transporter. Positron emission tomography (PET) studies with [O-methyl-{sup 11}C]{beta}-CIT-FP ([{sup 11}C]{beta}-CIT-FP) has shown that equilibrium conditions were approached but, however, not reached at the end of measurement. Moreover, metabolite studies of [{sup 11}C]{beta}-CIT-FP in monkey plasma demonstrated a lipophilic-labelled metabolite that may enter the brain. We therefore labelled {beta}-CIT-FP with fluorine-18 in a position that may avoid the formation of labelled lipophilic metabolites. The more long-lived radionuclide ({sup 18}F) was used to allow for measurements over longer time. [N-fluoropropyl-{sup 18}F]{beta}-CIT-FP ([{sup 18}F]{beta}-CIT-FP) was prepared by N-alkylation of nor-{beta}-CIT with [{sup 18}F]fluoropropyl bromide. PET studies were performed in cynomolgus monkeys. [{sup 18}F]{beta}-CIT-FP entered the brain rapidly. There was a high concentration of radioactivity in the striatum and much lower in the thalamus, neocortex, and cerebellum. The striatum-to-cerebellum ratio was about 5 at time of transient equilibrium, which occurred after 60 to 100 min. After pretreatment with GBR 12909, radioactivity in the striatum was markedly reduced, thus indicating specific [{sup 18}F]{beta}-CIT-FP binding to the dopamine transporter. The fraction of unchanged [{sup 18}F]{beta}-CIT-FP determined by HPLC was 10-15% after 140 min. No lipophilic labelled metabolites were detected. The absence of measurable lipophilic labelled metabolites and the occurrence of transient equilibrium within the time of the PET measurement indicate that [{sup 18}F]{beta}-CIT-FP is superior to [{sup 11}C]{beta}-CIT-FP as a PET radioligand for quantification of the dopamine transporter in the human brain.

  17. Lp-dual affine surface area

    Science.gov (United States)

    Wei, Wang; Binwu, He

    2008-12-01

    According to the notion of Lp-affine surface area by Lutwak, in this paper, we introduce the concept of Lp-dual affine surface area. Further, we establish the affine isoperimetric inequality and the Blaschke-Santaló inequality for Lp-dual affine surface area. Besides, the dual Brunn-Minkowski inequality for Lp-dual affine surface area is presented.

  18. Women's development key to MCH/FP.

    Science.gov (United States)

    1991-05-01

    The Sri Lankan government has included women in its development process thereby raising literacy levels to 91% for urban women and 87% for rural women. Their successful participation has in turn resulted in improvements in maternal and child health (MCH) and family planning (FP) acceptance. Indeed MCH/FP promotion could not have occurred without their participation in development. Since the 1960s, the Health and Women's Affairs Ministry continues to provide broad support for grass roots health care, such as strengthening the capacity of local clinics to increase coverage of health monitoring for women and children. There fore infant mortality in Sri Lanka has decreased from 47.5 in 1970 to 34 in 1980 to 19 in 1989. In addition, the total fertility rate fell from 5 in 1962-1964 to 3.4 in 1980-1982 to 2.8 in 1982-1987. The Ministry initiated its Integrated FP, Nutrition, and Parasite Control Project (IP) in 8 pilot areas in 1981. IP continues to encourage women's developed and MCH/FP at the grass roots level. In fact, FP acceptance rates increased from 31.8% in 1980 to 59% in 1989 in Nakulugamuwa and from 2.3% in 1980 to 70.5% in 1989 in Galnewa. The MCH component operating from community level clinics includes growth monitoring and immunization. Project activities include construction of latrines and wells, promotion of regular health examinations for mothers and children, FP education, counseling, nutrition promotion for children, and training programs for health staff, community volunteers, mothers' groups, and teachers. The volunteers form a link between the community and government health workers. Mothers' groups participate in school nutrition programs, home gardening, and income generation. Parasite control is consequently accomplished by community health and environmental sanitation promotion.

  19. Suggestion for a homogenizer installation in LOFT small break two-phase measurement

    International Nuclear Information System (INIS)

    Rieger, G.

    1981-07-01

    The purpose of this task, which was performed as an Austrian inkind contribution for the INEL research program is a) the evaluation of literature concerning homogenizers to improve two phase flow measurements for the LOFT small break test series, b) design of a homogenizer and c) recommandation of the location of a homogenizer in the LOFT piping system. To optimize the location of the homogenizer LTSF-tests should be performed according to the suggestions in this paper. (author)

  20. Investigation of effect of single phase electrical faults at LOFT

    International Nuclear Information System (INIS)

    Yeates, J.A.

    1978-01-01

    This LTR presents the general basic engineering facts related to an open phase fault in a three phase power system commonly referred to as a single phase condition. It describes the probable results to electrical motors and describes the LOFT system design factors which minimize the likelihood of such a fault occurring at LOFT. It recognizes that the hazard of such a fault is a realistic threat and notes the types of relays designed to provide protection. Recommendations are made to perform a detailed engineering study to determine the most advantageous protective relay design, and to implement such a design by installation of the necessary devices and controls

  1. Phebus FP. An international severe accident research programme

    International Nuclear Information System (INIS)

    Hardt, P.; Tattegrain, A.

    1995-01-01

    The main hazard during a hypothetical severe nuclear reactor accident resides in its fission product (FP) inventory. For this reason, the behaviour of FPs has been extensively studied, with the aim of determining the potential source to the environment. The Phebus FP programme proposes a novel, integral approach to this research. After 5 years of construction and of analytical preparation the Phebus FP programme has been supplying a large volume of new experimental data. Their processing by code calculations is presently a major challenge to all partners. The intense collaboration of 25 organizations from 15 countries has proven to be a major asset of Phebus FP. (author). 6 refs., 2 figs

  2. The PHEBUS FP project. Status report 1989-1990

    International Nuclear Information System (INIS)

    Scott de Martinville, E.F.; Delchambre, P.; Von der Hardt, P.

    1992-01-01

    Major achievements of PHEBUS Fission Product (FP) Programme during the year 1989 have been - seismic safety studies and civil engineering design of buildings and major components - transition into the detail design phase of experimental equipment and instrumentation - first orders for large components and other long delivery items - detailed definition of the test matrix - adaptation of existing, and generation of specific computation tools - dimensioning verification of the overall design proposal and of the first irradiation test - specific supporting studies, like analytical aerosol experiments, FP chemistry research, gamma spectrometry system layout, neutronic calculations. This report describes the experimental equipment, as defined in spring of 1990, and the underlying analytical studies. It updates earlier publications but can be read as a stand-alone description of PHEBUS FP. The present schedule forecasts the first in-pile test, with fresh fuel, by the middle of 1992

  3. LOFT experimental measurements uncertainty analyses. Volume XX. Fluid-velocity measurement using pulsed-neutron activation

    International Nuclear Information System (INIS)

    Lassahn, G.D.; Taylor, D.J.N.

    1982-08-01

    Analyses of uncertainty components inherent in pulsed-neutron-activation (PNA) measurements in general and the Loss-of-Fluid-Test (LOFT) system in particular are given. Due to the LOFT system's unique conditions, previously-used techniques were modified to make the volocity measurement. These methods render a useful, cost-effective measurement with an estimated uncertainty of 11% of reading

  4. The LOFT mission concept: a status update

    NARCIS (Netherlands)

    Feroci, M.; Bozzo, E.; Brandt, S.; Hernanz, M.; van der Klis, M.; Liu, L. -P; Orleanski, P.; Pohl, M.; Santangelo, A.; Schanne, S.; Stella, L.; Takahashi, T.; Tamura, H.; Watts, A.; Wilms, J.; Zane, S.; Zhang, S. -N; Bhattacharyya, S.; Agudo, I.; Ahangarianabhari, M.; Albertus, C.; Alford, M.; Alpar, A.; Altamirano, D.; Alvarez, L.; Amati, L.; Amoros, C.; Andersson, N.; Antonelli, A.; Argan, A.; Artigue, R.; Artigues, B.; Atteia, J. -L; Azzarello, P.; Bakala, P.; Ballantyne, D.; Baldazzi, G.; Baldo, M.; Balman, S.; Barbera, M.; van Baren, C.; Barret, D.; Baykal, A.; Begelman, M.; Behar, E.; Behar, O.; Belloni, T.; Bernardini, F.; Bertuccio, G.; Bianchi, S.; Bianchini, A.; Binko, P.; Blay, P.; Bocchino, F.; Bode, M.; Bodin, P.; Bombaci, I.; Bonnet Bidaud, J. -M; Boutloukos, S.; Bouyjou, F.; Bradley, L.; Braga, J.; Briggs, M. S.; Brown, E.; Buballa, M.; Bucciantini, N.; Burderi, L.; Burgay, M.; Bursa, M.; Budtz-Jørgensen, C.; Cackett, E.; Cadoux, F.; Cais, P.; Caliandro, G. A.; Campana, R.; Campana, S.; Cao, X.; Capitanio, F.; Casares, J.; Casella, P.; Castro-Tirado, A. J.; Cavazzuti, E.; Cavechi, Y.; Celestin, S.; Cerda-Duran, P.; Chakrabarty, D.; Chamel, N.; Château, F.; Chen, C.; Chen, Y.; Chenevez, J.; Chernyakova, M.; Coker, J.; Cole, R.; Collura, A.; Coriat, M.; Cornelisse, R.; Costamante, L.; Cros, A.; Cui, W.; Cumming, A.; Cusumano, G.; Czerny, B.; D'Aı, A.; D'Ammando, F.; D'Elia, V.; Dai, Z.; Del Monte, E.; De Luca, A.; De Martino, D.; Dercksen, J. P. C.; De Pasquale, M.; De Rosa, A.; Del Santo, M.; Di Cosimo, S.; Degenaar, N.; den Herder, J. W.; Diebold, S.; Di Salvo, T.; Dong, Y.; Donnarumma, I.; Doroshenko, V.; Doyle, G.; Drake, S. A.; Durant, M.; Emmanoulopoulos, D.; Enoto, T.; Erkut, M. H.; Esposito, P.; Evangelista, Y.; Fabian, A.; Falanga, M.; Favre, Y.; Feldman, C.; Fender, R.; Feng, H.; Ferrari, V.; Ferrigno, C.; Finger, M.; Finger, M. H.; Fraser, G. W.; Frericks, M.; Fullekrug, M.; Fuschino, F.; Gabler, M.; Galloway, D. K.; Gálvez Sanchez, J. L.; Gandhi, P.; Gao, Z.; Garcia-Berro, E.; Gendre, B.; Gevin, O.; Gezari, S.; Giles, A. B.; Gilfanov, M.; Giommi, P.; Giovannini, G.; Giroletti, M.; Gogus, E.; Goldwurm, A.; Goluchová, K.; Götz, D.; Gou, L.; Gouiffes, C.; Grandi, P.; Grassi, M.; Greiner, J.; Grinberg, V.; Groot, P.; Gschwender, M.; Gualtieri, L.; Guedel, M.; Guidorzi, C.; Guy, L.; Haas, D.; Haensel, P.; Hailey, M.; Hamuguchi, K.; Hansen, F.; Hartmann, D. H.; Haswell, C. A.; Hebeler, K.; Heger, A.; Hempel, M.; Hermsen, W.; Homan, J.; Hornstrup, A.; Hudec, R.; Huovelin, J.; Huppenkothen, D.; Inam, S. C.; Ingram, A.; In't Zand, J. J. M.; Israel, G.; Iwasawa, K.; Izzo, L.; Jacobs, H. M.; Jetter, F.; Johannsen, T.; Jenke, P. A.; Jonker, P.; Josè, J.; Kaaret, P.; Kalamkar, K.; Kalemci, E.; Kanbach, G.; Karas, V.; Karelin, D.; Kataria, D.; Keek, L.; Kennedy, T.; Klochkov, D.; Kluzniak, W.; Koerding, E.; Kokkotas, K.; Komossa, S.; Korpela, S.; Kouveliotou, C.; Kowalski, A. F.; Kreykenbohm, I.; Kuiper, L. M.; Kunneriath, D.; Kurkela, A.; Kuvvetli, I.; La Franca, F.; Labanti, C.; Lai, D.; Lamb, F. K.; Lachaud, C.; Laubert, P. P.; Lebrun, F.; Li, X.; Liang, E.; Limousin, O.; Lin, D.; Linares, M.; Linder, D.; Lodato, G.; Longo, F.; Lu, F.; Lund, N.; Maccarone, T. J.; Macera, D.; Maestre, S.; Mahmoodifar, S.; Maier, D.; Malcovati, P.; Malzac, J.; Malone, C.; Mandel, I.; Mangano, V.; Manousakis, A.; Marelli, M.; Margueron, J.; Marisaldi, M.; Markoff, S. B.; Markowitz, A.; Marinucci, A.; Martindale, A.; Martínez, G.; McHardy, I. M.; Medina-Tanco, G.; Mehdipour, M.; Melatos, A.; Mendez, M.; Mereghetti, S.; Migliari, S.; Mignani, R.; Michalska, M.; Mihara, T.; Miller, M. C.; Miller, J. M.; Mineo, T.; Miniutti, G.; Morsink, S.; Motch, C.; Motta, S.; Mouchet, M.; Mouret, G.; Mulačová, J.; Muleri, F.; Muñoz-Darias, T.; Negueruela, I.; Neilsen, J.; Neubert, T.; Norton, A. J.; Nowak, M.; Nucita, A.; O'Brien, P.; Oertel, M.; Olsen, P. E. H.; Orienti, M.; Orio, M.; Orlandini, M.; Osborne, J. P.; Osten, R.; Ozel, F.; Pacciani, L.; Paerels, F.; Paltani, S.; Paolillo, M.; Papadakis, I.; Papitto, A.; Paragi, Z.; Paredes, J. M.; Patruno, A.; Paul, B.; Pederiva, F.; Perinati, E.; Pellizzoni, A.; Penacchioni, A. V.; Peretz, U.; Perez, M. A.; Perez-Torres, M.; Peterson, B. M.; Petracek, V.; Pittori, C.; Pons, J.; Portell, J.; Possenti, A.; Postnov, K.; Poutanen, J.; Prakash, M.; Prandoni, I.; Le Provost, H.; Psaltis, D.; Pye, J.; Qu, J.; Rambaud, D.; Ramon, P.; Ramsay, G.; Rapisarda, M.; Rashevski, A.; Rashevskaya, I.; Ray, P. S.; Rea, N.; Reddy, S.; Reig, P.; Reina Aranda, M.; Remillard, R.; Reynolds, C.; Rezzolla, L.; Ribo, M.; de la Rie, R.; Riggio, A.; Rios, A.; Rischke, D. H.; Rodríguez-Gil, P.; Rodriguez, J.; Rohlfs, R.; Romano, P.; Rossi, E. M. R.; Rozanska, A.; Rousseau, A.; Rudak, B.; Russell, D. M.; Ryde, F.; Sabau-Graziati, L.; Sakamoto, T.; Sala, G.; Salvaterra, R.; Salvetti, D.; Sanna, A.; Sandberg, J.; Savolainen, T.; Scaringi, S.; Schaffner-Bielich, J.; Schatz, H.; Schee, J.; Schmid, C.; Serino, M.; Shakura, N.; Shore, S.; Schnittman, J. D.; Schneider, R.; Schwenk, A.; Schwope, A. D.; Sedrakian, A.; Seyler, J. -Y; Shearer, A.; Slowikowska, A.; Sims, M.; Smith, A.; Smith, D. M.; Smith, P. J.; Sobolewska, M.; Sochora, V.; Soffitta, P.; Soleri, P.; Song, L.; Spencer, A.; Stamerra, A.; Stappers, B.; Staubert, R.; Steiner, A. W.; Stergioulas, N.; Stevens, A. L.; Stratta, G.; Strohmayer, T. E.; Stuchlik, Z.; Suchy, S.; Suleimanov, V.; Tamburini, F.; Tauris, T.; Tavecchio, F.; Tenzer, C.; Thielemann, F. K.; Tiengo, A.; Tolos, L.; Tombesi, F.; Tomsick, J.; Torok, G.; Torrejon, J. M.; Torres, D. F.; Torresi, E.; Tramacere, A.; Traulsen, I.; Trois, A.; Turolla, R.; Turriziani, S.; Typel, S.; Uter, P.; Uttley, P.; Vacchi, A.; Varniere, P.; Vaughan, S.; Vercellone, S.; Vietri, M.; Vincent, F. H.; Vrba, V.; Walton, D.; Wang, J.; Wang, Z.; Watanabe, S.; Wawrzaszek, R.; Webb, N.; Weinberg, N.; Wende, H.; Wheatley, P.; Wijers, R.; Wijnands, R.; Wille, M.; Wilson-Hodge, C. A.; Winter, B.; Walk, S. J.; Wood, K.; Woosley, S. E.; Wu, X.; Xu, R.; Yu, W.; Yuan, F.; Yuan, W.; Yuan, Y.; Zampa, G.; Zampa, N.; Zampieri, L.; Zdunik, L.; Zdziarski, A.; Zech, A.; Zhang, B.; Zhang, C.; Zhang, S.; Zingale, M.; Zwart, F.

    2016-01-01

    The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large

  5. An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [{sup 18}F]FP-TZTP

    Energy Technology Data Exchange (ETDEWEB)

    Oosten, Erik M. van [Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 (Canada); PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Wilson, Alan A.; Stephenson, Karin A. [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Mamo, David C. [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Geriatric Mental Health Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario, M6J 1H4 (Canada); Pollock, Bruce G.; Mulsant, Benoit H. [Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Geriatric Mental Health Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario, M6J 1H4 (Canada); Yudin, Andrei K. [Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 (Canada); Houle, Sylvain [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Vasdev, Neil [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada)], E-mail: neil.vasdev@camhpet.ca

    2009-04-15

    The radioligand 3-(4-(3-[{sup 18}F]fluoropropylthio)-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5, 6-tetrahydropyridine ([{sup 18}F]FP-TZTP) is an agonist with specificity towards subtype 2 of muscarinic acetylcholine (M2) receptors. It is currently the only radiotracer available for imaging M2 receptors in human subjects with positron emission tomography. The present study reports on an improved method for the synthesis of [{sup 18}F]FP-TZTP, automated using a GE TRACERlab{sup TM} FX{sub FN} radiosynthesis module. A key facet was the use of a new precursor, 3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio) propyl 4-methylbenzenesulfonate. The precursor was fluorinated via nucleophilic displacement of the tosyloxy group by potassium cryptand [{sup 18}F]fluoride (K[{sup 18}F]/K{sub 222}) in CH{sub 3}CN at 80 deg. C for 5 min, and purified by HPLC. Formulated [{sup 18}F]FP-TZTP was prepared in an uncorrected radiochemical yield of 29{+-}4%, with a specific activity of 138{+-}41 GBq/{mu}mol (3732{+-}1109 mCi/{mu}mol) at the end of synthesis (35 min; n=3). This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported.

  6. Radioactive gas and hydrogen removal after a LOCE at the LOFT Facility

    International Nuclear Information System (INIS)

    McCormick-Barger, J.W.; Sumpter, K.C.

    1979-01-01

    The use of a silver-zeolite halogen adsorber placed in series with a hydrogen catalytic recombiner and a cryogenic noble gas adsorber assembly constitutes a waste gas processing system (WGPS) capable of handling hydrogen and fission product gases following a Loss-of-Coolant Experiment (LOCE). This paper describes: the types and quantities of gases expected to be found at the facility after a failed-fuel LOCE; the purpose of the WGPS; and the general configuration and expected decontamination factors associated with the LOFT WGPS

  7. Statistical margin to DNB safety analysis approach for LOFT

    International Nuclear Information System (INIS)

    Atkinson, S.A.

    1982-01-01

    A method was developed and used for LOFT thermal safety analysis to estimate the statistical margin to DNB for the hot rod, and to base safety analysis on desired DNB probability limits. This method is an advanced approach using response surface analysis methods, a very efficient experimental design, and a 2nd-order response surface equation with a 2nd-order error propagation analysis to define the MDNBR probability density function. Calculations for limiting transients were used in the response surface analysis thereby including transient interactions and trip uncertainties in the MDNBR probability density

  8. BEMUSE Phase III Report - Uncertainty and Sensitivity Analysis of the LOFT L2-5 Test

    International Nuclear Information System (INIS)

    Bazin, P.; Crecy, A. de; Glaeser, H.; Skorek, T.; Joucla, J.; Probst, P.; Chung, B.; Oh, D.Y.; Kyncl, M.; Pernica, R.; Macek, J.; Meca, R.; Macian, R.; D'Auria, F.; Petruzzi, A.; Perez, M.; Reventos, F.; Fujioka, K.

    2007-02-01

    This report summarises the various contributions (ten participants) for phase 3 of BEMUSE: Uncertainty and Sensitivity Analyses of the LOFT L2-5 experiment, a Large-Break Loss-of-Coolant-Accident (LB-LOCA). For this phase, precise requirements step by step were provided to the participants. Four main parts are defined, which are: 1. List and uncertainties of the input uncertain parameters. 2. Uncertainty analysis results. 3. Sensitivity analysis results. 4. Improved methods, assessment of the methods (optional). 5% and 95% percentiles have to be estimated for 6 output parameters, which are of two kinds: 1. Scalar output parameters (First Peak Cladding Temperature (PCT), Second Peak Cladding Temperature, Time of accumulator injection, Time of complete quenching); 2. Time trends output parameters (Maximum cladding temperature, Upper plenum pressure). The main lessons learnt from phase 3 of the BEMUSE programme are the following: - for uncertainty analysis, all the participants use a probabilistic method associated with the use of Wilks' formula, except for UNIPI with its CIAU method (Code with the Capability of Internal Assessment of Uncertainty). Use of both methods has been successfully mastered. - Compared with the experiment, the results of uncertainty analysis are good on the whole. For example, for the cladding temperature-type output parameters (1. PCT, 2. PCT, time of complete quenching, maximum cladding temperature), 8 participants out of 10 find upper and lower bounds which envelop the experimental data. - Sensitivity analysis has been successfully performed by all the participants using the probabilistic method. All the used influence measures include the range of variation of the input parameters. Synthesis tables of the most influential phenomena and parameters have been plotted and participants will be able to use them for the continuation of the BEMUSE programme

  9. Evaluating the Latent Structure of the MMPI-2 F(p) Scale in a Forensic Sample: A Taxometric Analysis

    Science.gov (United States)

    Strong, David R.; Glassmire, David M.; Frederick, Richard I.; Greene, Roger L.

    2006-01-01

    P. A. Arbisi and Y. S. Ben-Porath (1995) originally proposed that the Infrequency Psychopathology scale, F(p), be used as the final step in an algorithm to determine the validity of a Minnesota Multiphasic Personality Inventory-2 (MMPI-2) protocol. The current study used taxometric procedures to determine the latent structure of F(p) among…

  10. LpMab-19 Recognizes Sialylated O-Glycan on Thr76 of Human Podoplanin.

    Science.gov (United States)

    Ogasawara, Satoshi; Kaneko, Mika K; Kato, Yukinari

    2016-08-26

    Human podoplanin (hPDPN) is expressed in lymphatic vessels, pulmonary type-I alveolar cells, and renal glomerulus. The hPDPN/C-type lectin-like receptor-2 (CLEC-2) interaction is involved in platelet aggregation and cancer metastasis. High expression of hPDPN in cancer cells or cancer-associated fibroblasts (CAFs) leads to a poor prognosis for cancer patients. In our previous research, we reported on several anti-hPDPN monoclonal antibodies (mAbs), including LpMab-2, LpMab-3, LpMab-7, LpMab-9, LpMab-12, LpMab-13, and LpMab-17 of mouse IgG 1 subclass, which were produced using CasMab technology. Here we produced a novel anti-hPDPN mAb LpMab-19 of mouse IgG 2b subclass. Flow cytometry revealed that the epitope of LpMab-19 includes O-glycan, which is attached to Thr76 of hPDPN. We further identified the minimum epitope of LpMab-19 as Thr76-Arg79 of hPDPN. Immunohistochemistry revealed that LpMab-19 is useful for detecting not only normal cells, including lymphatic vessels, but also glioblastoma and oral squamous cell carcinoma cells. LpMab-19 could be useful for investigating the physiological function of O-glycosylated hPDPN.

  11. ICAP [International Code Assessment and Applications Program] assessment of RELAP5/MOD2, Cycle 36.05 against LOFT [Loss of Fluid Test] Small Break Experiment L3-7

    International Nuclear Information System (INIS)

    Lee, Euy-Joon; Chung, Bud-Dong; Kim, Hho-Jung

    1990-04-01

    The LOFT small break (1 in-dia) experiment L3-7 has been analyzed using the reactor thermal hydraulic analysis code RELAP5/MOD2, Cycle 36.05. The base calculation (Case A) was completed and compared with the experimental data. Three types of sensitivity studies (Cases B, Cm, and D) were carried out to investigate the effects of (1) break discharge coefficient Cd, (2) pump two-phase difference multiplier and (3) High Pressure Injection System (HPIS) capacity on major thermal and hydraulic (T/H) parameters. A nodalization study (Case E) was conducted to assess the phenomena with a simplified nodalization. The results indicate that Cd of 0.9 and 0.1 fit to the single discharge flow rate of Test L3-7 best among the tried cases. The pump two-phase multiplier has little effects on the T/H parameters because of the low discharge flow rate and the early pump coast down in this smaller size SBLOCA. But HPIS capacity has a very strong influence on parameters such as pressure, flow and temperature. It is also shown that a simplified nodalization could accomodate the dominant T/H phenomena with the same degree of code accuracy and efficiency

  12. Some Inequalities for the Lp-Curvature Image

    Directory of Open Access Journals (Sweden)

    Xiang Yu

    2009-01-01

    Full Text Available Lutwak introduced the notion of Lp-curvature image and proved an inequality for the volumes of convex body and its Lp-curvature image. In this paper, we first give an monotonic property of Lp-curvature image. Further, we establish two inequalities for the Lp-curvature image and its polar, respectively. Finally, an inequality for the volumes of Lp-projection body and Lp-curvature image is obtained.

  13. Collaboration on HiPER EU FP7 Project

    International Nuclear Information System (INIS)

    Rhee, Yong Joo; Han, Jae Min; Nam, Sung Mo; Chung, Chin Man; Lim, Chang Hwan; Cha, Yong Ho; Kwon, Duck Hee

    2011-06-01

    European Union started the HiPER project to establish a laser fusion research facility for energy production in Europe. Feasibility study and conceptual design has been performed for 2 years from 2005 and based on this study HiPER preparatory phase project has been proposed in 2007 as a EU FP7 project by 10 European countries and approved by EC. The project started in April of 2008 officially for 36 months until April of 2011. HiPER is a unique pure civilian laser fusion research facility and supported by ESFRI road map. KAERI has been participating HiPER from the feasibility study phase and still collaborating with HiPER EU FP7 project officially with the funding from the Korean government. Through this technical collaboration, participation in the joint experiments at large laser facilities has been possible and infrastructure of scientists exchange has been established Although the EU FP7 HiPER preparatory phase project ends at April of 2011 (actually it is extended until 2013 without further budget allocation fm EC) the total HiPER programme is planned to continue for more than 10 more years until the construction and commission of the fusion reactor. And KAERI also continue to participate in the HiPER programme in the future until the end of the programme

  14. Trigonometric bases for matrix weighted Lp-spaces

    DEFF Research Database (Denmark)

    Nielsen, Morten

    2010-01-01

    We give a complete characterization of 2π-periodic matrix weights W for which the vector-valued trigonometric system forms a Schauder basis for the matrix weighted space Lp(T;W). Then trigonometric quasi-greedy bases for Lp(T;W) are considered. Quasi-greedy bases are systems for which the simple...

  15. Advanced LP turbine blade design

    International Nuclear Information System (INIS)

    Jansen, M.; Pfeiffer, R.; Termuehlen, H.

    1990-01-01

    In the 1960's and early 1970's, the development of steam turbines for the utility industry was mainly influenced by the demand for increasing unit sizes. Nuclear plants in particular, required the design of LP turbines with large annulus areas for substantial mass and volumetric steam flows. Since then the development of more efficient LP turbines became an ongoing challenge. Extensive R and D work was performed in order to build efficient and reliable LP turbines often exposed to severe corrosion, erosion and dynamic excitation conditions. This task led to the introduction of an advanced disk-type rotor design for 1800 rpm LP turbines and the application of a more efficient, reaction-type blading for all steam turbine sections including the first stages of LP turbines. The most recent developments have resulted in an advanced design of large LP turbine blading, typically used in the last three stages of each LP turbine flow section. Development of such blading required detailed knowledge of the three dimensional, largely transonic, flow conditions of saturated steam. Also the precise assessment of blade stressing from dynamic conditions, such as speed and torsional resonance, as well as stochastic and aerodynamic excitation is of extreme importance

  16. Pilot investigation of the circadian plasma melatonin rhythm across the menstrual cycle in a small group of women with premenstrual dysphoric disorder.

    Directory of Open Access Journals (Sweden)

    Ari Shechter

    Full Text Available Women with premenstrual dysphoric disorder (PMDD experience mood deterioration and altered circadian rhythms during the luteal phase (LP of their menstrual cycles. Disturbed circadian rhythms may be involved in the development of clinical mood states, though this relationship is not fully characterized in PMDD. We therefore conducted an extensive chronobiological characterization of the melatonin rhythm in a small group of PMDD women and female controls. In this pilot study, participants included five women with PMDD and five age-matched controls with no evidence of menstrual-related mood disorders. Participants underwent two 24-hour laboratory visits, during the follicular phase (FP and LP of the menstrual cycle, consisting of intensive physiological monitoring under "unmasked", time-isolation conditions. Measures included visual analogue scale for mood, ovarian hormones, and 24-hour plasma melatonin. Mood significantly (P≤.03 worsened during LP in PMDD compared to FP and controls. Progesterone was significantly (P = .025 increased during LP compared to FP, with no between-group differences. Compared to controls, PMDD women had significantly (P<.05 decreased melatonin at circadian phases spanning the biological night during both menstrual phases and reduced amplitude of its circadian rhythm during LP. PMDD women also had reduced area under the curve of melatonin during LP compared to FP. PMDD women showed affected circadian melatonin rhythms, with reduced nocturnal secretion and amplitude during the symptomatic phase compared to controls. Despite our small sample size, these pilot findings support a role for disturbed circadian rhythms in affective disorders. Possible associations with disrupted serotonergic transmission are proposed.

  17. Policy subjects of the LP gas industry; LP gas sangyo no seisaku kadai

    Energy Technology Data Exchange (ETDEWEB)

    Murata, K. [Agency of Natural Resources and Energy, Tokyo (Japan)

    1996-09-01

    The paper commented on current environmental changes in the LP gas industry and the measures for reinforcement of the physical constitution. When correction of the high cost structure in Japan is now the problem, waves of deregulation and rationalization reach to not only to LP gas but energy competitive with LP gas such as petroleum, electric power and town gas. With this, it is expected that LP gas will be faced with severe competition with other energy media. In the LP gas industry, business becomes more and more in number and smaller and smaller in scale as it extends downstream. Therefore, the resulting complicatedness in the distribution sector is the problem. It is necessary to realize scale profit in each distribution stage and to heighten productivity by expanding the scale in the retailing stage, especially. It is also important to tackle scale merit, improvement of productivity, and cost reduction by concentrating functions on either of wholesalers or retailers in every function of delivery, safety, free from each distribution stage.

  18. Positron emission tomography imaging of cardiomyocyte apoptosis with a novel molecule probe [18F]FP-DPAZn2

    Science.gov (United States)

    Sun, Ting; Tang, Ganghua; Tian, Hua; Hu, Kongzhen; Yao, Shaobo; Su, Yifan; Wang, Changqian

    2015-01-01

    Cardiomyocyte apoptosis plays a causal role in the development and progression of heart failure. Currently, there is no effective imaging agent that can be used to detect cardiomyocyte apoptosis in vivo. To target phosphatidylserine (PS) on the surface of the dying cell, we synthesized a novel 18F-labeled Zn2+-dipicolylamine (DPA) analog, [18F]FP-DPAZn2, and evaluated it for noninvasive imaging of cardiomyocyte apoptosis. In vitro, the fluorescence imaging of dansyl-DPAZn2 was suitable for detecting cardiomyocyte apoptosis, which was confirmed by confocal immunofluorescence imaging, terminal dUTP nick-end labeling (TUNEL) assay, and western blot assay. The in vivo biodistribution showed that the uptake ratios of [18F]FP-DPAZn2 in the heart were 4.41±0.29% ID/g at 5 min, 2.40 ± 0.43% ID/g at 30 min, 1.63 ± 0.26% ID/g at 60 min, and 1.43% ± 0.07 ID/g at 120 min post-injection. In vivo, the [18F]FP-DPAZn2 PET images showed more cardiac accumulation of radioactivity 60 min post-injection in acute myocardial infarction (AMI) rats than in normal rats, which was consistent with the findings of a histological analysis of the rat cardiac tissues in vitro. [18F]FP-DPAZn2 PET imaging has the capability for myocardial apoptosis detection, but the method will require improved myocardial uptake for the noninvasive evaluation of cardiomyocyte apoptosis in clinical settings. PMID:26416423

  19. Shell-model results in fp and fpg9/2 spaces for 61,63,65Co isotopes

    International Nuclear Information System (INIS)

    Srivastava, P. C.; Kota, V. K. B.

    2011-01-01

    Low-lying spectra and several high-spin states of odd-even 61,63,65 Co isotopes are calculated in two different shell-model spaces. First set of calculations have been carried out in fp-shell valence space (full fp space for 63,65 Co and a truncated one for 61 Co) using two recently derived fp-shell interactions, namely GXPF1A and KB3G, with 40 Ca as core. Similarly, the second set of calculations have been performed in fpg 9/2 valence space using an fpg effective interaction due to Sorlin et al., with 48 Ca as core and imposing a truncation. It is seen that the results of GXPF1A and KB3G are reasonable for 61,63 Co. For 65 Co, shell-model results show that the fpg interaction adopted in the study is inadequate and also points out that it is necessary to include orbitals higher than 1g 9/2 for neutron-rich Co isotopes.

  20. View of the LP gas supply/demand in Asia and a survey of the Middle East trend; Asia no LP gas jukyu tenbo to Chuto doko chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    A study was made on the LP gas supply/demand in Asia including an outlook for 2000. Eleven countries in Asia including NIES countries, ASEAN countries, China and India have been continuing their rapid growth of economy and have rapidly been increasing their energy consumption. There, LP gas spreads as a home use fuel, and countries excluding some LP gas producing countries depend considerably upon the import from the Middle East. The LP gas consumption quantity is steadily increasing in China and India having huge population, etc., and dependence of LP gas is increasing upon LP gas producing countries of the Middle East. Nevertheless, in the Middle East, the domestic consumption of LP gas, mostly butane, is increasing. Namely, butane is used as raw material of MTBE, and LP gas as that of petroleum chemicals. The Middle East has a lot of plant projects of a sizable size in the future, which predicts that LP gas export from LP gas producing countries of the Middle East is decreasing. 2 refs., 62 figs., 57 tabs.

  1. A comparison of core degradation phenomena in the CORA, QUENCH, Phébus SFD and Phébus FP experiments

    Energy Technology Data Exchange (ETDEWEB)

    Haste, T., E-mail: tim.haste@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP 3, F-13115 St. Paul-lez-Durance Cedex (France); Steinbrück, M., E-mail: martin.steinbrueck@kit.edu [Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Barrachin, M., E-mail: marc.barrachin@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP 3, F-13115 St. Paul-lez-Durance Cedex (France); Luze, O. de, E-mail: olivier.de-luze@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP 3, F-13115 St. Paul-lez-Durance Cedex (France); Grosse, M., E-mail: mirco.grosse@kit.edu [Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Stuckert, J., E-mail: juri.stuckert@kit.edu [Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)

    2015-03-15

    Highlights: • The results of the experiments CORA, QUENCH and Phébus SFD/FP are summarised. • All phenomena expected up to melt movement to the lower head are shown consistently. • Separate-effect tests performed at KIT and IRSN aid improve their modelling. • Data from the integral tests help independent validation of new and improved models. • The improved codes will help reduce uncertainties in safety-critical areas for core degradation. - Abstract: Over the past 20 years, integral fuel bundle experiments performed at IRSN Cadarache, France (Phébus-SFD and Phébus FP – fission heated) and at Karlsruhe Institute of Technology, Germany (CORA and QUENCH – electrically heated), accompanied by separate-effect tests, have provided a wealth of detailed information on core degradation phenomena that occur under severe accident conditions, relevant to such safety issues as in-vessel retention of the core, recovery of the core by water reflood, hydrogen generation and fission product release. These data form an important basis for development and validation of severe accident analysis codes such as ASTEC (IRSN/GRS, EC) and MELCOR (USNRC/SNL, USA) that are used to assess the safety of current and future reactor designs, so helping to reduce the uncertainty associated with such code predictions. Following the recent end of the Phébus FP project, it is appropriate now to compare the core degradation phenomena observed in these four major experimental series, indicating the main conclusions that have been drawn. This covers subjects such as early phase degradation up to loss of rod-like geometry (all the series), late phase degradation and the link between fission product release and core degradation (Phébus FP), oxidation phenomena (all the series), reflood behaviour (CORA and QUENCH), as well as particular topics such as the effects of control rod material and fuel burn-up on core degradation. It also outlines the separate-effects experiments performed to

  2. Transverse stress induced LP 02-LP 21 modal interference of stimulated Raman scattered light in a few-mode optical fiber

    Science.gov (United States)

    Sharma, A.; Posey, R.

    1996-02-01

    Four-photon mixing followed by stimulated Raman scattering is observed in LP 02 mode in a 7.9 μm core diameter optical fiber. A localized transverse stress efficiency couples LP 02 to the LP 21 mode with a macroscopic beat length of 1.8 mm. LP 02-LP 21 modal interference is investigated by detecting the 550-590 nm SRS through a pinhole in the far field exit plane. Quantitative explanation of wavelength dependent intensity modulation results in a precise experimental determination of {∂[β 02(λ) - β 21(λ)] }/{∂λ}, for mode-propagation constants β02( λ) and β21( λ) of LP 02 and LP 21 modes respectively, as well as Δ, the relative core-cladding refractive index difference. The LP 02-LP 21 modal interference is used for sensing of temperature between 50-300°C.

  3. Uncertainty and sensitivity analysis of the LOFT L2-5 test: Results of the BEMUSE programme

    International Nuclear Information System (INIS)

    Crecy, A. de; Bazin, P.; Glaeser, H.; Skorek, T.; Joucla, J.; Probst, P.; Fujioka, K.; Chung, B.D.; Oh, D.Y.; Kyncl, M.; Pernica, R.; Macek, J.; Meca, R.; Macian, R.; D'Auria, F.; Petruzzi, A.; Batet, L.; Perez, M.; Reventos, F.

    2008-01-01

    This paper presents the results and the main lessons learnt from the phase 3 of BEMUSE, an international benchmark activity sponsored by the Committee on the Safety of Nuclear Installations [CSNI: Committee on the Safety of Nuclear Installations (NEA, OECD), 2007. BEMUSE Phase III Report. NEA/CSNI R(2007) 4, October 2007] of the OECD/NEA. The phase 3 of BEMUSE aimed at performing Uncertainty and Sensitivity Analyses of thermal-hydraulic codes used for the calculation of LOFT L2-5 experiment, which simulated a Large-Break Loss-of-Coolant-Accident (LB-LOCA). Eleven participants coming from ten organisations and eight countries took part in this benchmark. In the first section of this paper, the context of BEMUSE is described as well as the methods used by the participants. In the second section, the results of the benchmark are presented. The majority of the participants find uncertainty bands which envelop the experimental data fairly well, however the width of these bands is much diverged. A synthesis of the sensitivity analysis results has been made and is expected to provide a useful basis for further uncertainty analysis dealing with LB-LOCA. Finally, recommendations are given both for uncertainty and sensitivity analysis

  4. LOFT CIS analysis penetration S-11B 12'' H and V duct

    International Nuclear Information System (INIS)

    Condie, C.G.

    1978-01-01

    The 12 in. H and V Duct and related piping outside the LOFT containment and connected to containment penetration S-11B was analyzed to ASME Code, Subsection NC (Class 2) criteria. This duct is part of the Containment Isolation System. The model considered the duct from the containment O.D. outward through the second isolation valve. Results of this analysis show that this section of the line will meet Class 2 requirements without modification

  5. LP-THAE induced tumor cell apoptosis of rabbit VX2 liver carcinoma

    International Nuclear Information System (INIS)

    Chen Shengli; Quan Yi; Huang Zicheng; Chen Guodong; Zhu Dongliang

    2007-01-01

    Objective: To research tumor cell apoptosis induced by Lp-THAE of rabbit VX2 liver implanted tumor. Methods: 27 New Zealand white rabbits implanted with VX2 tumor at left middle lobe of the liver divided into three groups: Group A(n= 9) Lp-THAE: treated through transhepatic artery catheterization; Group B(n=9) THAI and Group C(n=9) as control. The rabbits were executed at second to fifth day after treatment. HE dye microscopy was taken for counting the typical apoptosis cells and calculating apoptosis index (ApI). FITC-AnnexinV/PI assay was used for measuring apoptosis by flow cytometry. Results: The ApI of tumor central area and marginal area were (17.769±2.417)%, (4.129±1.172)%, P<0.01. The percentages of tumor cell apoptosis and tumor cell necrosis were (16.483±1.404)%, (9.478±0.964)%, P<0.01 and (43.559±5.053)%, (33.460±1.840)%, P=0.093. The total percentages of tumor cell apoptosis and necrosis were (60.042±13.979)%, (42.938±8.979)%, P< 0.01, at tumor center and marginal area in THAE group respectively. The ApI, percentages of tumor cell apoptosis and necrosis in THAE group were significantly higher than those of THAI group (P<0.01). The percentages of tumor cell apoptosis at tumor center area in THAE group were significantly higher than those of tumor marginal area(P<0.01). Conclusion: Induced tumor cell apoptosis and necrosis are two mechanisms of action for Lp-THAE treatment of liver carcinoma. (authors)

  6. Synthesis of [18F]-N-3-fluoro-propyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([18F]-FP-β-CIT)

    International Nuclear Information System (INIS)

    Fang Ping; Chen Zhengping; Lin Yansong; Zhou Xian; Du Yikui

    2001-01-01

    The ligand of N-(3-fluoro-propyl)-2β-carbomethoxy-3β-(4'-iodophenyl) nortropane (FP-β-CIT) and mesylate precursor were synthesized by hydrolysis of cocaine, followed by dehydration, esterification, Grignard reaction, N-demethylation, iodination, N-alkylation with 3-bromo-propanol and methyl-sulfonyl. Finally, 18 F-FP-β-CIT was prepared by nucleophilic fluorination of the mesylate with K 18 F/K 2.2.2 (Kryptofix). The labelling yield of 18 F-FP-β-CIT is 25%-30%. The total radiochemical yield of this compound, calculated from the end of bombardment (EOB) with decay correction, is 10%-12% with a synthesis time of 100-110 min. The radiochemical purity of 18 F-FP-β-CIT is greater than 90%, and this compound in aqueous solution is also stable for more than 4 hours at room temperature. It is stable enough for clinical study

  7. Modeling photoabsorption of the asFP595 chromophore.

    Science.gov (United States)

    Bravaya, Ksenia B; Bochenkova, Anastasia V; Granovsky, Alexander A; Savitsky, Alexander P; Nemukhin, Alexander V

    2008-09-18

    The fluorescent protein asFP595 is a promising photoswitchable biomarker for studying processes in living cells. We present the results of a high level theoretical study of photoabsorption properties of the model asFP595 chromophore molecule in biologically relevant protonation states: anionic, zwitterionic, and neutral. Ground state equilibrium geometry parameters are optimized in the PBE0/(aug)-cc-pVDZ density functional theory approximation. An augmented version of multiconfigurational quasidegenerate perturbation theory (aug-MCQDPT2) following the state-averaged CASSCF/(aug)-cc-pVDZ calculations is used to estimate the vertical S0-S1 excitation energies for all chromophore species. An accuracy of this approach is validated by comparing the computed estimates of the S0-S1 absorption maximum of the closely related chromophore from the DsRed protein to the known experimental value in the gas phase. An influence of the CASSCF active space on the aug-MCQDPT2 excitation energies is analyzed. The zwitterionic form of the asFP595 chromophore is found to be the most sensitive to a particular choice and amount of active orbitals. This observation is explained by the charge-transfer type of the S0-S1 transition involving the entire conjugated pi-electron system for the zwitterionic protonation state. According to the calculation results, the anionic form in the trans conformation is found to possess the most red-shifted absorption band with the maximum located at 543 nm. The bands of the zwitterionic and neutral forms are considerably blue-shifted compared to those of the anionic form. These conclusions are at variance with the results obtained in the TDDFT approximation for the asFP595 chromophore. The absorption wavelengths computed in the aug-MCQDPT2/CASSCF theory are as follows: 543 (535), 470 (476), and 415 (417) nm for the anionic, zwitterionic, and neutral forms of the trans and cis (in parentheses) isomers of the asFP595 chromophore. These data can be used as a

  8. LOFT data acquisition and visual display system (DAVDS) presentation program

    International Nuclear Information System (INIS)

    Bullock, M.G.; Miyasaki, F.S.

    1976-03-01

    The Data Acquisition and Visual Display System (DAVDS) at the Loss-of-Fluid Test Facility (LOFT) has 742 data channel recording capability of which 576 are recorded digitally. The purpose of this computer program is to graphically present the data acquired and/or processed by the LOFT DAVDS. This program takes specially created plot data buffers of up to 1024 words and generates time history plots on the system electrostatic printer-plotter. The data can be extracted from two system input devices: Magnetic disk or digital magnetic tape. Versatility has been designed in the program by providing the user three methods of scaling plots: Automatic, control record, and manual. Time required to produce a plot on the system electrostatic printer-plotter varies from 30 to 90 seconds depending on the options selected. The basic computer and program details are described

  9. SN 2016coi/ASASSN-16fp: An example of residual helium in a type Ic supernova?

    Science.gov (United States)

    Prentice, S. J.; Ashall, C.; Mazzali, P. A.; Zhang, J.-J.; James, P. A.; Wang, X.-F.; Vinkó, J.; Percival, S.; Short, L.; Piascik, A.; Huang, F.; Mo, J.; Rui, L.-M.; Wang, J.-G.; Xiang, D.-F.; Xin, Y.-X.; Yi, W.-M.; Yu, X.-G.; Zhai, Q.; Zhang, T.-M.; Hosseinzadeh, G.; Howell, D. A.; McCully, C.; Valenti, S.; Cseh, B.; Hanyecz, O.; Kriskovics, L.; Pál, A.; Sárneczky, K.; Sódor, Á.; Szakáts, R.; Székely, P.; Varga-Verebélyi, E.; Vida, K.; Bradac, M.; Reichart, D. E.; Sand, D.; Tartaglia, L.

    2018-05-01

    The optical observations of Ic-4 supernova (SN) 2016coi/ASASSN-16fp, from ˜2 to ˜450 days after explosion, are presented along with analysis of its physical properties. The SN shows the broad lines associated with SNe Ic-3/4 but with a key difference. The early spectra display a strong absorption feature at ˜5400 Åwhich is not seen in other SNe Ic-3/4 at this epoch. This feature has been attributed to HeIin the literature. Spectral modelling of the SN in the early photospheric phase suggests the presence of residual He in a C/O dominated shell. However, the behaviour of the HeIlines is unusual when compared with He-rich SNe, showing relatively low velocities and weakening rather than strengthening over time. The SN is found to rise to peak ˜16 d after core-collapse reaching a bolometric luminosity of Lp ˜ 3 × 1042 erg s-1. Spectral models, including the nebular epoch, show that the SN ejected 2.5 - 4 M⊙of material, with ˜1.5 M⊙below 5000 km s-1, and with a kinetic energy of (4.5 - 7) × 1051 erg. The explosion synthesised ˜0.14 M⊙of 56Ni. There are significant uncertainties in E(B - V)host and the distance however, which will affect Lp and MNi. SN 2016coi exploded in a host similar to the Large Magellanic Cloud (LMC) and away from star-forming regions. The properties of the SN and the host-galaxy suggest that the progenitor had MZAMS of 23 - 28 M⊙and was stripped almost entirely down to its C/O core at explosion.

  10. Lessons from cross-fleet/cross-airline observations - Evaluating the impact of CRM/LOFT training

    Science.gov (United States)

    Butler, Roy E.

    1991-01-01

    A review is presented of the crew resource management/line oriented flight training (CRM/LOFT) program to help determine the level of standardization across fleets and airlines in the critical area of evaluating crew behavior and performance. One of the goals of the project is to verify that check airmen and LOFT instructors within organizations are evaluating CRM issues consistently and that differences observed between fleets are not a function of idiosyncracies on the part of observers. Attention is given to the research tools for crew evaluation.

  11. Lp-mixed affine surface area

    Science.gov (United States)

    Wang, Weidong; Leng, Gangsong

    2007-11-01

    According to the three notions of mixed affine surface area, Lp-affine surface area and Lp-mixed affine surface area proposed by Lutwak, in this article, we give the concept of ith Lp-mixed affine surface area such that the first and second notions of Lutwak are its special cases. Further, some Lutwak's results are extended associated with this concept. Besides, applying this concept, we establish an inequality for the volumes and dual quermassintegrals of a class of star bodies.

  12. Whither α-FP in the diagnosis of hepatocellular carcinoma?

    Directory of Open Access Journals (Sweden)

    Kew MC

    2015-08-01

    Full Text Available Michael C Kew1,2 1Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 2University of the Witwatersrand, Johannesburg, South Africaα-FP is an α1-globulin present in high concentration in the fetal serum of mammals. It is the dominant plasma protein in the developing embryo, and is synthesized by the embryonal liver, by the endodermal cells of the visceral yolk sac, and, in very small amounts, by the embryonal intestine.1 Approximately 80% of fetal hepatocytes synthesize and secrete α-FP. The protein has been closely conserved throughout phylogenesis, suggesting that it has functions essential to the fetus, although precisely what these functions are remains to be learned. There does, however, appear to be an inverse relationship between serum α-FP and albumin levels, suggesting that α-FP might function as fetal albumin.2 Other possible biological properties of the α1-globulin include binding to estrogens and bilirubin, immunosuppressive activity, and a growth-promoting potential.3 The serum level of the protein remains constant until week 32, when it begins to sharply decrease. After birth, production of α-FP normally remains completely repressed, and serum concentrations are correspondingly very low.

  13. Displacement sensor for measurement of fuel rod elongation in the LOFT reactors

    International Nuclear Information System (INIS)

    Billeter, T.R.

    1979-09-01

    Qualification tests conducted for a period of 700 hours of each of three displacement measuring (LVDT) sensors confirmed applicability of the design for use in the Loss-of-Fluid-Test (LOFT) reactor. Operationally, the sensor satisfies all specified requirements for LOFT. Even for imposed temperature transients at rates up to 100 0 F/s, the indicated displacement remained within the allowed maximum error band of +- 10% of reading. The 0.6-inch O.D. by 5.5-inch long sensor exhibited a linearly related signal output variation for displacement variations of up to 1-inch range. Long term operation at temperatures of 100 0 F to 800 0 F caused no perceptible permanent change of operating characteristics

  14. TRAC-PF1 analysis of LOFT steam-generator feedwater transient test L9-1

    International Nuclear Information System (INIS)

    Meier, J.K.

    1983-01-01

    The Transient Reactor Analysis Code (TRAC-PF1) calculations were compared to test data from Loss-of-Fluid Test (LOFT) L9-1, which was a loss-of-feedwater transient. This paper includes descriptions of the test and the TRAC input and compares the TRAC-calculated results with the test data. We conclude that the code predicted the experiment well, given the uncertainties in the boundary conditions. The analysis indicates the need to model all the flow paths and heat structures, and to improve the TRAC wall condensation heat-transfer model

  15. Data sheets of fission product release experiments for light water reactor fuel, (2)

    International Nuclear Information System (INIS)

    Ishiwatari, Nasumi; Nagai, Hitoshi; Takeda, Tsuneo; Yamamoto, Katsumune; Nakazaki, Chozaburo.

    1979-07-01

    This is the second data sheets of fission products (FP) release experiments for light water reactor fuel. Results of five FP release experiments from the third to the seventh are presented: results of pre-examinations of UO 2 pellets, photographs of parts of fuel rod assemblies for irradiation and the assemblies, operational conditions of JMTR and OWL-1, variations of radioiodine-131 level in the main loop coolant during experimental periods, and representative results of post-irradiation examinations of respective fuel rods. (author)

  16. LOFT CIS analysis: 24'' H and V Duct outside penetration S-12A

    International Nuclear Information System (INIS)

    Pierce, A.T.

    1978-01-01

    The 24'' H and V Duct and related piping outside the LOFT containment and connected to containment penetration S-12A were analyzed to ASME Section III, Subsection NC (Class 2) criteria. The duct is part of the Containment Isolation System. The model considered the duct from the containment O.D. outward through the second isolation valve. Results of this analysis show that this section of the line will meet Class 2 requirements without modification

  17. Revisiting LOFT L2-5 large break test in BEMUSE project context. Sensitivity studies

    International Nuclear Information System (INIS)

    Perez, Marina; Batet, Lluis; Pretel, Carme; Reventos, Francesc

    2005-01-01

    Full text of publication follows: Best estimate codes simulate NPPs behavior in principle without any special conservative assumptions. Due to several factors like code solution methods or user effects, the output parameters calculated have an uncertainty associated. The quantification of the these uncertainties becomes crucial when a safety statement is to be made. It is in this scope that GAMA group from CSNI (OECD/NEA) proposed the international BEMUSE project (Best Estimate - Uncertainty and Sensitivity Evaluation) having as main objective the evaluation of different methodologies for the uncertainty and sensitivity analysis of best-estimate code calculations. A number of methodologies prepared in different countries are used in the development of the project activities. The program work consists of 6 phases and currently the first two have already been concluded. Phase II consists in revisiting the ISP-13, the LOFT loss of coolant experiment L2-5 which simulated a double ended 200% cold leg break of a commercial PWR simultaneous with a loss of site power. In order to connect phase II with phase III, in which the uncertainty analysis will be carried out, quite a large number of sensitivity analysis have been performed by simulating system failures and varying fuel elements parameters among others. The presentation will focus on the results of the sensitivity analysis as well as its importance with regards to the uncertainty studies. The methodology used by UPC team was developed by ENUSA and the work is supported by the Spanish regulatory organization. (authors)

  18. Loft: An Automated Mesh Generator for Stiffened Shell Aerospace Vehicles

    Science.gov (United States)

    Eldred, Lloyd B.

    2011-01-01

    Loft is an automated mesh generation code that is designed for aerospace vehicle structures. From user input, Loft generates meshes for wings, noses, tanks, fuselage sections, thrust structures, and so on. As a mesh is generated, each element is assigned properties to mark the part of the vehicle with which it is associated. This property assignment is an extremely powerful feature that enables detailed analysis tasks, such as load application and structural sizing. This report is presented in two parts. The first part is an overview of the code and its applications. The modeling approach that was used to create the finite element meshes is described. Several applications of the code are demonstrated, including a Next Generation Launch Technology (NGLT) wing-sizing study, a lunar lander stage study, a launch vehicle shroud shape study, and a two-stage-to-orbit (TSTO) orbiter. Part two of the report is the program user manual. The manual includes in-depth tutorials and a complete command reference.

  19. LOFT diesel generator ''A'' exhaust stack seismic analysis

    International Nuclear Information System (INIS)

    Blandford, R.K.

    1978-01-01

    A stress analysis of the LOFT Diesel Generator ''A'' Exhaust Stack was performed to determine its reaction to Safe-Shutdown Earthquake loads. The exhaust stack silencer and supporting foundation was found to be inadequate for the postulated seismic accelerations. Lateral support is required to prevent overturning of the silencer pedestal and reinforcement of the 4'' x 0.5'' silencer base straps is necessary. Basic requirements for this additional support are discussed

  20. Superiority of SDS lysis over saponin lysis for direct bacterial identification from positive blood culture bottle by MALDI-TOF MS.

    Science.gov (United States)

    Caspar, Yvan; Garnaud, Cécile; Raykova, Mariya; Bailly, Sébastien; Bidart, Marie; Maubon, Danièle

    2017-05-01

    Fast species diagnosis has an important health care impact, as rapid and specific antibacterial therapy is of clear benefit for patient's outcome. Here, a new protocol for species identification directly from positive blood cultures is proposed. Four in-house protocols for bacterial identification by MS directly from clinical positive blood cultures evaluating two lytic agents, SDS and saponin, and two protein extraction schemes, fast (FP) and long (LP) are compared. One hundred and sixty-eight identification tests are carried out on 42 strains. Overall, there are correct identifications to the species level in 90% samples for the SDS-LP, 60% for the SDS-FP, 48% for the saponin LP, and 43% for the saponin FP. Adapted scores allowed 92, 86, 72, and 53% identification for SDS-LP, SDS-FP, saponin LP, and saponin FP, respectively. Saponin lysis is associated with a significantly lower score compared to SDS (0.87 [0.83-0.92], p-value saponin lysis and the application of this rapid and cost-effective protocol in daily routine for microbiological agents implicated in septicemia. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Evaluation of Protective Immune Responses Induced by Recombinant TrxLp and ENO2 Proteins against Toxoplasma gondii Infection in BALB/c Mice

    Directory of Open Access Journals (Sweden)

    Meng Wang

    2016-01-01

    Full Text Available Toxoplasma gondii is an obligate intracellular parasitic protozoan that can infect almost all species of warm-blooded animals. As any chemical-based drugs could not act against the tissue cyst stage of T. gondii, vaccination may be one of the ideal control strategies. In the present study, two new vaccine candidates, named TgENO2 and TgTrxLp, were purified from Escherichia coli with pET-30a(+ expression system and then were injected into BALB/c mice to evaluate the protective efficacy against acute and chronic toxoplasmosis. The results showed that both the recombinant proteins, either alone or in combination, could elicit strong humoral and cellular immune responses with a higher level of IgG antibodies, IFN-γ, IL-2, CD4+, and CD8+ T cells as compared to those in mice from control groups. After acute challenge with tachyzoites of the GJS strain, mice immunized with rTgTrxLp (8±2.77 d, rTgENO2 (7.4±1.81 d, and rTgTrxLp + rTgENO2 (8.38±4.57 d proteins showed significantly longer survival time than those that received Freund’s adjuvant (6.78±2.08 d and PBS (6.38±4.65 d (χ2 = 9.687, df = 4, P=0.046. The protective immunity of rTgTrxLp, rTgENO2, and rTgTrxLp + rTgENO2 proteins against chronic T. gondii infection showed 69.77%, 58.14%, and 20.93% brain cyst reduction as compared to mice that received PBS. The present study suggested that both TgENO2 and TgTrxLp were potential candidates for the development of multicomponent vaccines against toxoplasmosis.

  2. ^2H(^18F,p)^19F Study at 6 MeV/u

    Science.gov (United States)

    Kozub, R. L.; Nesaraja, C. D.; Moazen, B. H.; Scott, J. P.; Bardayan, D. W.; Blackmon, J. C.; Gross, C. J.; Shapira, D.; Smith, M. S.; Batchelder, J. C.; Brune, C. R.; Champagne, A. E.; Sahin, L.; Cizewski, J. A.; Thomas, J. S.; Davinson, T.; Woods, P. J.; Greife, U.; Jewett, C.; Livesay, R. J.; Ma, Z.; Parker, P. D.

    2003-04-01

    The degree to which the (p,α) and (p,γ) reactions destroy ^18F at temperatures ˜1-4 x 10^8 K is important for understanding the synthesis of nuclei in nova explosions and for using ^18F as a monitor of nova mechanisms in gamma ray astronomy. The reactions are dominated by low-lying proton resonances near the ^18F+p threshold (E_x=6.411 MeV excitation energy in ^19Ne). To gain further information about these resonances, we have used the inverse ^18F(d,p)^19F neutron transfer reaction at the Holifield Radioactive Ion Beam Facility to selectively populate corresponding mirror states in ^19F. Proton angular distributions were measured for states in ^19F in the excitation energy range 0-9 MeV. Results and implications for the ^18F+p reactions and nuclear structure will be presented. ^1Supported by DOE. ^2ORNL is managed by UT-Battelle, LLC, for the USDOE.

  3. Low-order model of the Loss-of-Fluid Test (LOFT) reactor plant for use in Kalman filter-based optimal estimators

    International Nuclear Information System (INIS)

    Tylee, J.L.

    1980-01-01

    A low-order, nonlinear model of the Loss-of-Fluid Test (LOFT) reactor plant, for use in Kalman filter estimators, is developed, described, and evaluated. This model consists of 31 differential equations and represents all major subsystems of both the primary and secondary sides of the LOFT plant. Comparisons between model calculations and available LOFT power range testing transients demonstrate the accuracy of the low-order model. The nonlinear model is numerically linearized for future implementation in Kalman filter and optimal control algorithms. The linearized model is shown to be an adequate representation of the nonlinear plant dynamics

  4. LOFT CIS analysis penetration S-7A 8'' WW - 172-AB

    International Nuclear Information System (INIS)

    Barry, W.J. Jr.

    1978-01-01

    The 8'' WW - 172 - AB line from the containment penetration S-7A was analyzed to ASME Code, Subsection NC (Class 2) criteria. This section of piping is part of the LOFT Containment Isolation System. The model considered the line from the penetration S-7A outward through two horizontal-plane elbows and then through three valves to a wall penetration. Results of the analysis show that the system will meet Class 2 requirements if additional support/restraint is installed at three locations besides the existing restraints. The locations and loads for these supports/restraints are included in the body of the report

  5. The Lp_3561 and Lp_3562 enzymes support a functional divergence process in the lipase/esterase toolkit from Lactobacillus plantarum

    Directory of Open Access Journals (Sweden)

    Maria Esteban-Torres

    2016-07-01

    Full Text Available Lactobacillus plantarum species is a good source of esterases since both lipolytic and esterase activities have been described for strains of this species. No fundamental biochemical difference exists among esterases and lipases since both share a common catalytic mechanism. L. plantarum WCFS1 possesses a protein, Lp_3561, which is 44% identical to a previously described lipase, Lp_3562. In contrast to Lp_3562, Lp_3561 was unable to degrade esters possessing a chain length higher than C4 and the triglyceride tributyrin. As in other L. plantarum esterases, the electrostatic potential surface around the active site in Lp_3561 is predicted to be basic, whereas it is essentially neutral in the Lp_3562 lipase. The fact that the genes encoding both proteins were located contiguously in the L. plantarum WCFS1 genome, suggests that they originated by tandem duplication, and therefore are paralogs as new functions have arisen during evolution. The presence of the contiguous lp_3561 and lp_3562 genes was studied among L. plantarum strains. They are located in a 8,903 bp DNA fragment that encodes proteins involved in the catabolism of sialic acid and are predicted to increase bacterial adaptability under certain growth conditions.

  6. Assessment of predictive capability of REFLA/TRAC code for large break LOCA transient in PWR using LOFT L2-5 test data

    International Nuclear Information System (INIS)

    Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio

    1994-03-01

    The REFLA/TRAC code is a best estimate code developed at Japan Atomic Energy Research Institute (JAERI) to provide advanced predictions of thermal hydraulic transient in light water reactors (LWRs). The REFLA/TRAC code uses the TRAC-PF1/MOD1 code as the framework of the code. The REFLA/TRAC code is expected to be used for the calibration of licensing codes, accident analysis, accident simulation of LWRs, and design of advanced LWRs. Several models have been implemented to the TRAC-PF1/MOD1 code at JAERI including reflood model, condensation model, interfacial and wall friction models, etc. These models have been verified using data from various separate effect tests. This report describes an assessment result of the REFLA/TRAC code, which was performed to assess the predictive capability for integral system behavior under large break loss of coolant accident (LBLOCA) using data from the LOFT L2-5 test. The assessment calculation confirmed that the REFLA/TRAC code can predict break mass flow rate, emergency core cooling water bypass and clad temperature excellently in the LOFT L2-5 test. The CPU time of the REFLA/TRAC code was about 1/3 of the TRAC-PF1/MOD1 code. The REFLA/TRAC code can perform stable and fast simulation of thermal hydraulic behavior in PWR LBLOCA with enough accuracy for practical use. (author)

  7. Study of fp States in Nuclei with High Neutron Excess

    CERN Multimedia

    2002-01-01

    Previous results obtained at ISOLDE on GT transitions in n-rich Na and Mg nuclei have shown the sharp decrease of excitation energy for fp states when A$>$29. \\\\ \\\\ Independently, shell model calculations have revealed that the onset of a deformation region near N=20 for Ne, Na and Mg nuclei was related to a sudden transition in the ground state properties with the appearance of a major (sd)$^{-2}$(fp)$^2$ component. \\\\ \\\\ We propose to use the new possibilities of producing and detecting n-rich nuclei to study by $\\gamma$ and n spectroscopy the properties of fp states with different cores: around N=20 (Na, Mg and Al) and N=28 (Ar, K and Ca). In particular, the cases of $^3

  8. 78 FR 43874 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2013-07-22

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP13-514-000] Texas Eastern Transmission, LP; Notice of Application On July 2, 2013, Texas Eastern Transmission, LP (Texas Eastern) filed... natural gas facilities no longer in service. As described more fully in the Application, Texas Eastern...

  9. The FP7 ULTimateCO2 project: a study of the long term fate of CO2

    Science.gov (United States)

    Audigane, Pascal; Waldmann, Svenja; Pearce, Jonathan; Dimier, Alain; Le Gallo, Yann; Frykman, Peter; Maurand, Nicolas; Gherardi, Fabrizio; Yalamas, Thierry; Cremer, Holger; Spiers, Chris; Nussbaum, Christophe

    2014-05-01

    The objectives of the European FP7 ULTimateCO2 project are to study specific processes that could influence the long-term fate of geologically stored CO2, mainly: the trapping mechanisms occurring in the storage reservoir, the influence of fluid-rock interactions on mechanical integrity of caprock and well vicinity, and also the modifications induced at the regional scale (brine displacement, fault reactivation, hydrogeology changes...). A comprehensive approach combining laboratory experiments, numerical modeling and natural analogue studies is developed to assess all the processes mentioned above. A collection of data has been generated from natural and industrial (oil industry) analogues on the fluid flow and mechanical properties, structure, and mineralogy of faults and fractures that could affect the long-term storage capacity of underground CO2 storage sites. To address geochemical trapping at reservoir scale, an experimental approach is developed using sandstone core materials in batch reactive mode with CO2 and impurities at reservoir pressure and temperature conditions. Three inter-related lines of laboratory experiments investigate the long-term evolution of the mechanical properties and sealing integrity of fractured and faulted caprocks using Opalinus clay of Mont Terri Gallery (Switzerland), an analogue for caprock well investigated in the past for nuclear waste disposal purpose. To evaluate the interactions between CO2 (and formation fluid) and the well environment (formation, cement, casing) and to assess the consequences of these interactions on the transport properties of well materials, a 1 to 1 scale experiment has been set in the Mont Terri Gallery Opalinus clay to reproduce classical well objects (cemented annulus, casing and cement plug) perforating caprock formations. An extensive program of numerical modeling is also developed to calibrate, to reproduce and to extrapolate the experimental results at longer time scales including uncertainty

  10. DASH-FP, Multicomponent Time-Dependent Concentration Diffusion

    International Nuclear Information System (INIS)

    Apperson, C.E. Jr.; Carruthers, L.M.; Shinn, J.F.; Lee, C.E.

    1995-01-01

    1 - Description of program or function: The program DASH-FP calculates the transient concentration of multiple diffusing species with radioactive decay. 2 - Method of solution: Uses finite difference and exponential operator techniques

  11. The LOFT Burst Alert System and its Burst On-board Trigger

    DEFF Research Database (Denmark)

    Schanne, Stephane; Götz, Diego; Provost, Herve Le

    2014-01-01

    The ESA M3 candidate mission LOFT (Large Observatory For x-ray Timing) has been designed to study strong gravitational fields by observing compact objects, such as black-hole binaries or neutron-star systems and supermassive black-holes, based on the temporal analysis of photons collected...

  12. Stress analysis of LOFT steam generator blowdown cross-over line

    International Nuclear Information System (INIS)

    Singh, J.N.

    1978-01-01

    The purpose of this report is to demonstrate compliance of the LOFT Steam Generator Blowdown Cross-Over Piping with the ASME Boiler and Pressure Vessel Code, Section III, Subsection NC. Deadweight, thermal expansion, seismic, LOCE, and LOCA loads have been considered. With the addition of two snubbers, as shown in this report, the system conforms to all requirements

  13. Increase in Multicast OFDM Data Rate in PLC Network using Adaptive LP-OFDM

    OpenAIRE

    Maiga , Ali; Baudais , Jean-Yves; Hélard , Jean-François

    2009-01-01

    ISBN: 978-1-4244-3523-4; International audience; Linear precoding (LP) technique applied to OFDM systems has already proved its ability to significantly increase the system throughput in a powerline communication (PLC) context. In this paper, we propose resource allocation algorithms based on the LP technique to increase the multicast OFDM systems bit rate. The conventional multicast capacity is limited by the user which experiences the worst channel conditions. To increase the multicast bit ...

  14. Seismic stress analysis of feeder lines to LOFT primary coolant pump motors

    International Nuclear Information System (INIS)

    Kuehster, C.J.

    1978-01-01

    The conduit system in the LOFT Support Building was analyzed for seismic loading. The conduit itself plus its various supports were subjected to both horizontal and vertical forces. The results show the system loads or stresses to be within allowables

  15. 78 FR 21491 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption...

    Science.gov (United States)

    2013-04-10

    ... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662, 02/02-0661] DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P. and DeltaPoint...

  16. Advanced LP turbine installation at 1300 MW nuclear power station Unterweser

    International Nuclear Information System (INIS)

    Jacobsen, G.; Oeynhausen, H.; Termuehlen, H.

    1991-01-01

    This paper reports on Preussen Elektra AG's Unterweser power plant. The steam turbine-generator features a disk-type LP turbine rotor design developed in the late 1960's to early 1970's. This rotor design has been installed in 19 nuclear power plants. The 47 rotors in these plants have been in operation for an average of almost 10 years. The design of the 1970 vintage nuclear LP turbine rotors was based on extensive experience gained with disk-type rotors of fossil turbines built in the 1950's. When EPRI reported about corrosion cracking in nuclear LP turbines, a program was initiated by Siemens/KWU as original steam turbine supplier to ultrasonically inspect all their disk-type rotors in nuclear power plats. Indications on one rotor disk in the Unterweser plant was found. This single event was the only one found out of 310 disks inspected in nuclear power plants

  17. West Africa LP gas market development study

    International Nuclear Information System (INIS)

    2001-01-01

    Jointly sponsored with the World Bank, this essential study explores the opportunity for greatly expanded LP Gas use in the West Africa region. LP Gas supply in the area is increasing rapidly, This offers the opportunity for bringing modern energy to millions without current access, protects forests the only current source of energy for many, and encourages governments to adopt proactive policies that will reap benefits of the increasing availability of LP Gas. (author)

  18. Sediment Lofting From Melt-Water Generated Turbidity Currents During Heinrich Events as a Tool to Assess Main Sediment Delivery Phases to Small Subpolar Ocean Basins

    Science.gov (United States)

    Hesse, R.

    2009-05-01

    Small subpolar ocean basins such as the Labrador Sea received a major portion (25%) of their sediment fill during the Pleistocene glaciations (less than 5% of the basin's lifetime), but the detailed timing of sediment supply to the basin remained essentially unknown until recently. The main sediment input into the basin was probably not coupled to major glacial cycles and associated sea-level changes but was related to Heinrich events. Discovery of the depositional facies of fine-grained lofted sediment provides a tool which suggests that the parent-currents from which lofting took place may have been sandy-gravelly turbidity currents that built a huge braided abyssal plain in the Labrador Sea (700 by 120 km underlain by 150 m on average of coarse- grained sediment) which is one of the largest sand accumulations (104 km3) on Earth. The facies of lofted sediment consists of stacked layers of graded muds that contain ice-rafted debris (IRD) which impart a bimodal grain-size distribution to the graded muds. The texturally incompatible grain populations of the muds (median size between 4 and 8 micrometers) and the randomly distributed coarse silt and sand-sized IRD require the combination of two transport processes that delivered the populations independently and allowed mixing at the depositional site: (i) sediment rafting by icebergs (dropstones) and (ii) the rise of turbid freshwater plumes out of fresh-water generated turbidity currents. Sediment lofting from turbidity currents is a process that occurs in density currents generated from sediment-laden fresh-water discharges into the sea that can produce reversed buoyancy, as is well known from experiments. When the flows have traveled long enough, their tops will have lost enough sediment by settling so that they become hypopycnal (their density decreasing below that of the ambient seawater) causing the current tops to lift up. The turbid fresh-water clouds buoyantly rise out of the turbidity current to a level of

  19. LOFT CIS analysis: 24'' H and V Duct outside penetration S-12A

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, A.T.

    1978-08-18

    The 24'' H and V Duct and related piping outside the LOFT containment and connected to containment penetration S-12A were analyzed to ASME Section III, Subsection NC (Class 2) criteria. The duct is part of the Containment Isolation System. The model considered the duct from the containment O.D. outward through the second isolation valve. Results of this analysis show that this section of the line will meet Class 2 requirements without modification.

  20. L_p- and S_{p,q}^rB-discrepancy of (order 2) digital nets

    OpenAIRE

    Markhasin, Lev

    2014-01-01

    Dick proved that all order $2$ digital nets satisfy optimal upper bounds of the $L_2$-discrepancy. We give an alternative proof for this fact using Haar bases. Furthermore, we prove that all digital nets satisfy optimal upper bounds of the $S_{p,q}^r B$-discrepancy for a certain parameter range and enlarge that range for order $2$ digitals nets. $L_p$-, $S_{p,q}^r F$- and $S_p^r H$-discrepancy is considered as well.

  1. A flexible testing facility for high-power targets (Tiara FP7 program)

    CERN Document Server

    Fusco, Y.; Samec, K.; Kadi, Y.

    2014-01-01

    Building on recent experience in the field of applied physics, TIARA Work package n° 9 focuses on target applications for accelerators in Europe. A roadmap for target development has been derived from major achievements in the EU-FP6 and EU-FP7 programs such as the MEGAPIE and EURISOL experiments. The TIARA management board concluded that a worthwhile continuation of such projects would be in the development of a flexible material irradiation facility easily transportable and which could be installed in different laboratories. The power is limited to 100 kW in a very compact arrangement so as to obtain the best neutron economy from a moderate beam power which is more likely to be found in laboratories across Europe. The challenges posed by such a compact design and accompanying calculations are presented in the current work.

  2. LpMab-23: A Cancer-Specific Monoclonal Antibody Against Human Podoplanin.

    Science.gov (United States)

    Yamada, Shinji; Ogasawara, Satoshi; Kaneko, Mika K; Kato, Yukinari

    2017-04-01

    Human podoplanin (hPDPN), the ligand of C-type lectin-like receptor-2, is involved in cancer metastasis. Until now, many monoclonal antibodies (mAbs) have been established against hPDPN. However, it is still difficult to develop a cancer-specific mAb (CasMab) against hPDPN because the protein sequence of hPDPN expressed in cancer cells is the same as that in normal cells. Herein, we report LpMab-23 of the mouse IgG 1 subclass, a novel CasMab against hPDPN. In an immunohistochemical analysis, LpMab-23 reacted with tumor cells of human oral cancer, but did not react with normal cells such as lymphatic endothelial cells (LECs). In contrast, LpMab-17, another anti-hPDPN mAb, reacted with both tumor cells and LECs. Furthermore, flow cytometric analysis revealed that LpMab-23 reacted with hPDPN-expressing cancer cell lines (LN319, RERF-LC-AI/hPDPN, Y-MESO-14/hPDPN, and HSC3/hPDPN) but showed little reaction with normal cells (LECs and HEK-293T), although another anti-hPDPN mAb, LpMab-7, reacted with both hPDPN-expressing cancer cells and normal cells, indicating that LpMab-23 is a CasMab against hPDPN.

  3. LOFT advanced fuel rod instrumentation development

    International Nuclear Information System (INIS)

    Billeter, T.R.; Brown, R.L.; Chan, A.I.Y.; Day, C.K.; Meyers, S.C.; Sheen, E.M.; Stringer, J.L.

    1978-01-01

    Advanced fuel rod instrumentation for the Loss of Fluid Test (LOFT) reactor is being developed by the Hanford Engineering Development Laboratory for the Nuclear Regulatory Commission. This effort calls for development of sensors to measure fuel rod axial motion, fuel centerline temperature (to 2200 0 C), fuel rod plenum gas pressure (to 2500 psig), and plenum gas temperature (to 1500 0 F). A parallel test and evaluation of several modified commercial sensors was undertaken and will result in commercial availability of the final qualified sensors. Necessary test facilities were prepared for the development and evaluation effort. Tests to date indicate a three coil Linear Variable Differential Transformer (LVDT), operated from temperature compensating signal source and processing electronics, will meet the desired requirements

  4. Altered Circulating Levels of Serotonin and Immunological Changes in Laying Hens Divergently Selected for Feather Pecking Behavior

    DEFF Research Database (Denmark)

    Buitenhuis, Albert Johannes; Kjaer, Jørgen B.; Labouriau, Rodrigo

    2006-01-01

    The aim of this study was to investigate the changes in immunological parameters as well as changes with respect to plasma levels of serotonin and tryptophan in lines selected for and against feather pecking (FP) behavior [high FP (HP) line and low FP (LP) line] for 5 generations. The hens from...... response to infectious bursal disease virus vaccination after 1 wk post-vaccination compared with the control and LP lines. The number of white blood cells (P

  5. The role of natural organic matter in nitrite formation by LP-UV/H2O2 treatment of nitrate-rich water.

    Science.gov (United States)

    Semitsoglou-Tsiapou, Sofia; Mous, Astrid; Templeton, Michael R; Graham, Nigel J D; Hernández Leal, Lucía; Kruithof, Joop C

    2016-12-01

    The role of natural organic matter (NOM) on nitrite formation from nitrate photolysis by low pressure ultraviolet lamp (LP-UV) photolysis and LP-UV/H 2 O 2 treatment was investigated. Nitrate levels up to the WHO guideline maximum of 50 mg NO 3 - /L were used in tests. The presence of 4 mg/L Suwannee River natural organic matter (NOM) led to increased nitrite yields compared to NOM-free controls. This was caused partly by NOM scavenging of OH radicals, preserving the produced NO 2 - as well as the ONOO - that leads to NO 2 - formation, but also via the production of radical species ( 1 O 2 , O 2 - and OH) by the photolysis of NOM. In addition, solvated electrons formed by NOM photolysis may reduce nitrate directly to nitrite. For comparison, Nordic Lake NOM, representative of aquatic NOM, as well as Pony Lake NOM, which had a greater nitrogen content (6.51% w/w) than the other two types of NOM, were investigated, yielding similar nitrite levels as Suwannee River NOM. The results suggest that neither the type nor the nitrogen content of the NOM have an effect on the nitrite yields obtained over the range of UV/H 2 O 2 doses applied (UV fluences of 500-2100 mJ/cm 2 and hydrogen peroxide doses of 10, 25, and 50 mg/L). The findings indicate that for UV fluences above 1500 mJ/cm 2 the resulting nitrite concentration can exceed the 0.1 mg/L EU regulatory limit for nitrite, suggesting that nitrite formation by LP-UV advanced oxidation of nitrate-rich waters is important to consider. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Basics of FP promotion.

    Science.gov (United States)

    1994-03-01

    Joseph Van Arendonk, deputy executive director of the UN Population Fund (UNFPA), stated in an interview that UNFPA had identified the critical points of success for a family planning (FP) program. First is the public and consistent commitment of the political leadership of a country. Second, very good quality services must be readily available, the clinics should be clean, and the workers well-trained, especially in counseling. Third, services must be accessible and physically near to people, who must be informed of service availability. Fourth, women should have the ability to decide for themselves about their fertility. However, FP should be a joint decision, and therefore education for men is vital. Another important element to success is to have proper service statistics built into the FP program for assessment of the problem of dropping out and for a continuous program evaluation. Other aspects of management are good supervision and control as well as proper logistics. Although the Earth Summit made sustainable development the objective for the year 2000 and beyond, this goal is only viable if it is linked with an appropriate population policy. In population, the same kinds of challenges persist that existed 25 years ago. This is because once contraception is introduced, the relationship between men and women and the whole concept of family are changed, bringing about changes in society.

  7. STAR-CCM+ (CFD) Calculations and Validation L3:VVI.H2L.P15.02

    Energy Technology Data Exchange (ETDEWEB)

    Gilkey, Lindsay [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-05

    This milestone presents a demonstration of the High-to-Low (Hi2Lo) process in the VVI focus area. Validation and additional calculations with the commercial computational fluid dynamics code, STAR-CCM+, were performed using a 5x5 fuel assembly with non-mixing geometry and spacer grids. This geometry was based on the benchmark experiment provided by Westinghouse. Results from the simulations were compared to existing experimental data and to the subchannel thermal-hydraulics code COBRA-TF (CTF). An uncertainty quantification (UQ) process was developed for the STAR-CCM+ model and results of the STAR UQ were communicated to CTF. Results from STAR-CCM+ simulations were used as experimental design points in CTF to calibrate the mixing parameter β and compared to results obtained using experimental data points. This demonstrated that CTF’s β parameter can be calibrated to match existing experimental data more closely. The Hi2Lo process for the STAR-CCM+/CTF code coupling was documented in this milestone and closely linked L3:VVI.H2LP15.01 milestone report.

  8. Metabolism and autoradiographic evaluation of [{sup 18}F]FE-CIT: a Comparison with [{sup 123}I]{beta}-CIT and [{sup 123}I]FP-CIT

    Energy Technology Data Exchange (ETDEWEB)

    Ettlinger, Dagmar E. [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Haeusler, Daniela; Wadsak, Wolfgang [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Girschele, Friedrich; Sindelar, Karoline M. [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Mien, Leonhard-Key [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Ungersboeck, Johanna [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Viernstein, Helmut; Kletter, Kurt; Dudczak, Robert [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Mitterhauser, Markus [Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria); Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna (Austria)], E-mail: markus.mitterhauser@meduniwien.ac.at

    2008-05-15

    Purpose: Since the late 1980s, cocaine analogues based on the phenyltropane structure, such as [{sup 11}C]CFT and [{sup 123}I]{beta}-CIT have been used for the imaging of the dopamine transporter. FE-CIT (fluoropropyl ester) and FP-CIT (N-fluoropropyl derivative) are further analogues. The aim of this study was to (1) evaluate and compare the metabolic stability of {beta}-CIT, FP-CIT and FE-CIT against carboxyl esterases and (2) evaluate selectivity of [{sup 18}F]FE-CIT compared to [{sup 123}I]{beta}-CIT and [{sup 123}I]FP-CIT using autoradiography. Methods: In vitro enzymatic hydrolysis assays were performed using different concentrations of {beta}-CIT, FE-CIT and FP-CIT with constant concentrations of carboxyl esterase. Autoradiography was performed on coronal 20-{mu}m rat brain sections incubated with different radioactivity concentrations of [{sup 123}I]{beta}-CIT, [{sup 123}I]FP-CIT or [{sup 18}F]FE-CIT and, additionally, with 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile [serotonin transporter (SERT)] and nisoxetine [norepinephrine transporter (NET)] for blocking experiments. Results: In vitro assays showed Michaelis-Menten constants of 175 {mu}mol ({beta}-CIT), 183 {mu}mol (FE-CIT) and 521 {mu}mol (FP-CIT). Limiting velocities were 0.1005 {mu}mol/min ({beta}-CIT), 0.1418 {mu}mol/min (FE-CIT) and 0.1308 {mu}mol/min (FP-CIT). This indicates a significantly increased stability of FP-CIT, whereas carboxyl esterase stability of {beta}-CIT and FE-CIT showed no significant difference. Autoradiographic analyses revealed a good correlation between dopamine transporter (DAT)-rich regions and the uptake pattern of FE-CIT. Blocking experiments showed a higher DAT selectivity for [{sup 18}F]FE-CIT than for the other two tracers. Conclusion: We found that (1) the metabolic stability of FE-CIT was comparable to that of {beta}-CIT, whereas FP-CIT showed higher resistance to enzymatic hydrolysis; and (2) the overall uptake pattern of [{sup 18}F]FE-CIT on

  9. The Phebus FP project

    International Nuclear Information System (INIS)

    Delchambre, P.; Von der Hardt, P.

    1989-01-01

    This report summarizes the pre-project studies concerning the PHEBUS FP facility. After recalling the programme objectives, it describes the projected modifications to the PHEBUS reactor, outlines new installations and justifies the selected options

  10. Probing the emission physics and weak/soft population of Gamma-Ray Bursts with LOFT. White Paper in Support of the Mission Concept of the Large Observatory for X-ray Timing

    DEFF Research Database (Denmark)

    Amati, L.; Stratta, G.; Atteia, J.L.

    of ultra- dense matter in neutron stars? Does matter orbiting close to the event horizon follow the predictions of general relativity? These goals are elaborated in the mission Yellow Book ( http://sci.esa.int/loft/ 53447-loft-yellow-book/ ) describing the LOFT mission as proposed in M3, which closely...

  11. Status of the assessment phase of the ESA M3 mission candidate LOFT

    Science.gov (United States)

    Corral van Damme, Carlos; Ayre, Mark; Lumb, David; Short, Alexander D.; Rando, Nicola

    2012-09-01

    LOFT (Large Observatory For x-ray Timing) is one of four candidates for the M3 slot (launch in 2024, with the option of a launch in 2022) of ESAs Cosmic Vision 2015 - 2025 Plan, and as such it is currently undergoing an initial assessment phase lasting one year. The objective of the assessment phase is to provide the information required to enable the down selection process, in particular: the space segment definition for meeting the assigned science objectives; consideration of and initial definition of the implementation schedule; an estimate of the mission Cost at Completion (CaC); an evaluation of the technology readiness evaluation and risk assessment. The assessment phase is divided into two interleaved components: (i) A payload assessment study, performed by teams funded by member states, which is primarily intended for design, definition and programmatic/cost evaluation of the payload, and (ii) A system industrial study, which has essentially the same objectives for the space segment of the mission. This paper provides an overview of the status of the LOFT assessment phase, both for payload and platform. The initial focus is on the payload design status, providing the reader with an understanding of the main features of the design. Then the space segment assessment study status is presented, with an overview of the principal challenges presented by the LOFT payload and mission requirements, and a presentation of the expected solutions. Overall the mission is expected to enable cutting-edge science, is technically feasible, and should remain within the required CaC for an M3 candidate.

  12. Difluoro-lambda(5)-phosphinonitrile F(2)P[triple bond]N: matrix isolation and photoisomerization into FP=NF.

    Science.gov (United States)

    Zeng, Xiaoqing; Beckers, Helmut; Willner, Helge

    2009-01-01

    Splendid isolation: Monomeric phosphazene F(2)PN ((1)A(1)) was prepared for the first time through irradiation of F(2)PN(3) in an argon matrix with an ArF excimer laser (lambda=193 nm). Upon subsequent irradiation with a high-pressure mercury arc lamp (lambda=255 nm), F(2)PN undergoes a 1,2-fluorine shift to give iminophosphane cis-FP=NF.

  13. LOFT fuel modules design, characterization, and fabrication program

    International Nuclear Information System (INIS)

    Russell, M.L.

    1977-06-01

    The loss-of-fluid test [LOFT) fuel modules have evolved from a comprehensive five-year design, characterization, and fabrication program which has resulted in the accomplishment of many technical activities of interest in pressurized water reactor fuel design development and safety research. Information is presented concerning: determination of fundamental high-temperature reactor material properties; design invention related to in-core instrumentation attachment; implementation of advanced and/or unique fuel bundle characterization techniques; implementation of improved fuel bundle fabrication techniques; and planning and execution of a multimillion dollar design, characterization, and fabrication program for pressurized water reactor fuel

  14. Ejection and Lofting of Dust from Hypervelocity Impacts on the Moon

    Science.gov (United States)

    Hermalyn, B.; Schultz, P. H.

    2011-12-01

    Hypervelocity impact events mobilize and redistribute fine-grained regolith dust across the surfaces of planetary bodies. The ejecta mass-velocity distribution controls the location and emplacement of these materials. The current flux of material falling on the moon is dominated by small bolides and should cause frequent impacts that eject dust at high speeds. For example, approximately 25 LCROSS-sized (~20-30m diameter) craters are statistically expected to be formed naturally on the moon during any given earth year. When scaled to lunar conditions, the high-speed component of ejecta from hypervelocity impacts can be lofted for significant periods of time (as evidenced by the LCROSS mission results, c.f., Schultz, et al., 2010, Colaprete, et al., 2010). Even at laboratory scales, ejecta can approach orbital velocities; the higher impact speeds and larger projectiles bombarding the lunar surface may permit a significant portion of material to be launched closer to escape velocity. When these ejecta return to the surface (or encounter local topography), they impact at hundreds of meters per second or faster, thereby "scouring" the surface with low mass oblique impacts. While these high-speed ejecta represent only a small fraction of the total ejected mass, the lofting and subsequent ballistic return of this dust has the highest mobilization potential and will be directly applicable to the upcoming LADEE mission. A suite of hypervelocity impact experiments into granular materials was performed at the NASA Ames Vertical Gun Range (AVGR). This study incorporates both canonical sand targets and air-fall pumice dust to simulate the mechanical properties of lunar regolith. The implementation of a Particle Tracking Velocimetry (PTV) technique permits non-intrusive measurement of the ejecta velocity distribution within the ejecta curtain by following the path of individual ejecta particles. The PTV system developed at the AVGR uses a series of high-speed cameras (ranging

  15. LP formulation of asymmetric zero-sum stochastic games

    KAUST Repository

    Li, Lichun

    2014-12-15

    This paper provides an efficient linear programming (LP) formulation of asymmetric two player zero-sum stochastic games with finite horizon. In these stochastic games, only one player is informed of the state at each stage, and the transition law is only controlled by the informed player. Compared with the LP formulation of extensive stochastic games whose size grows polynomially with respect to the size of the state and the size of the uninformed player\\'s actions, our proposed LP formulation has its size to be linear with respect to the size of the state and the size of the uninformed player, and hence greatly reduces the computational complexity. A travelling inspector problem is used to demonstrate the efficiency of the proposed LP formulation.

  16. LP formulation of asymmetric zero-sum stochastic games

    KAUST Repository

    Li, Lichun; Shamma, Jeff S.

    2014-01-01

    This paper provides an efficient linear programming (LP) formulation of asymmetric two player zero-sum stochastic games with finite horizon. In these stochastic games, only one player is informed of the state at each stage, and the transition law is only controlled by the informed player. Compared with the LP formulation of extensive stochastic games whose size grows polynomially with respect to the size of the state and the size of the uninformed player's actions, our proposed LP formulation has its size to be linear with respect to the size of the state and the size of the uninformed player, and hence greatly reduces the computational complexity. A travelling inspector problem is used to demonstrate the efficiency of the proposed LP formulation.

  17. Effects of anesthetics on vesicular monoamine transporter type 2 binding to 18F-FP-(+)-DTBZ: a biodistribution study in rat brain

    International Nuclear Information System (INIS)

    Chen, Zhengping; Tang, Jie; Liu, Chunyi; Li, Xiaomin; Huang, Hongbo; Xu, Xijie; Yu, Huixin

    2016-01-01

    Objectives: The in vivo binding analysis of vesicular monoamine transporter type 2 (VMAT2) to radioligand has provided a means of investigating related disorders. Anesthesia is often inevitable when the investigations are performed in animals. In the present study, we tested effects of four commonly-used anesthetics: isoflurane, pentobarbital, chloral hydrate and ketamine, on in vivo VMAT2 binding to 18 F-FP-(+)-DTBZ, a specific VMAT2 radioligand, in rat brain. Methods: The transient equilibrium time window for in vivo binding of 18 F-FP-(+)-DTBZ after a bolus injection was firstly determined. The brain biodistribution studies under anesthetized and awake rats were then performed at the equilibrium time. Standard uptake values (SUVs) of the interest brain regions: the striatum (ST), hippocampus (HP), cortex (CX) and cerebellum (CB) were obtained; and ratios of tissue to cerebellum were calculated. Results: Isoflurane and pentobarbital did not alter distribution of 18 F-FP-(+)-DTBZ in the brain relative to the awake group; neither SUVs nor ratios of ST/CB and HP/CB were altered significantly. Chloral hydrate significantly increased SUVs of all the brain regions, but did not significantly alter ratios of ST/CB and HP/CB. Ketamine significantly increased SUVs of the striatum, hippocampus and cortex, and insignificantly increased the SUV of the cerebellum; consequently, ketamine significantly increased ratios of ST/CB and HP/CB. Conclusions: It is concluded that in vivo VMAT2 binding to 18 F-FP-(+)-DTBZ are not altered by isoflurane and pentobarbital, but altered by chloral hydrate and ketamine. Isoflurane and pentobarbital may be promising anesthetic compounds for investigating in vivo VMAT2 binding. Further studies are warranted to investigate the interactions of anesthetics with VMAT2 binding potential with in vivo PET studies.

  18. Flygtninge på langvarig starthjælp

    DEFF Research Database (Denmark)

    Johansen, Adam; Højland, Marianne; Hansen, Henning

    Spørgeskema-, fokusgruppe- og interviewbaseret undersøgelse af personlige og sociale konsekvenser af familiers forsørgelse på starthjælp. Kvalitativ og kvantitativ undersøgelse af starthjælpens konsekvenser for flygtningefamilier med mere end 1 år på starthjælp...

  19. RANS simulation of the thermal mixing in HTTF LP during normal operation conditions – High Temperature Test Facility at Oregon State University

    International Nuclear Information System (INIS)

    Gradecka, Malwina J.; Woods, Brian

    2014-01-01

    Since High Temperature Gas-cooled Reactors are being considered as the most promising design of upcoming IV Gen reactors, key research areas were identified to address safety aspects of this design. A number of simulations and experiments need to be conducted in this field. In this paper, thermal-hydraulics aspects of coolant flow through Lower Plenum (LP) of HTGR were considered, specifically flow characteristics to identify the risk of temperature stratification in LP and hot spotting on LP floor. Local temperature gradients can cause material degradation. As the power profile is non-uniform across the core, jets of coolant exit the core region at different temperatures and enter the LP impinging on LP floor causing hot spots at LP structure and temperature stratification. To address those issues numerical simulation and an experiment are being developed. The numerical simulation provides coolant flow velocity and temperature fields. The purpose of this study is to investigate the mixing phenomenon in the LP due to risk of the hot streaking and thermal stratification phenomena during normal operation of HTTF. The following aspect are being examined: identification of gas flow behavior in lower plenum of HTTF based on CFD simulations, identification of hot streaking issue in the HTTF lower plenum using CFD tools, and computational investigation of gas mixing efficiency. This paper includes a description of experimental setup of HTTF, guidance for LP CFD modeling, and the results and analysis of CFD simulation. (author)

  20. Corrosion fatigue in LP steam turbine blading - experiences, causes and appropriate measures; Korrosionsutmattning i aangturbinskovlar - Erfarenheter, inverkande faktorer och moejliga aatgaerder

    Energy Technology Data Exchange (ETDEWEB)

    Tavast, J [ABB STAL AB, Finspaang (Sweden)

    1996-12-01

    Corrosion fatigue in LP steam turbine blading was reviewed together with result of tests performed in order to find blade materials with improved resistance against this. According to international experience, corrosion fatigue of 12Cr steam turbine blades in the transition zone between dry and wet steam, is one of the major causes, if not the major cause, for unavailability of steam turbines. Corrosion fatigue in LP blading is a frequent problem also in Swedish and Finnish nuclear power plants, especially in turbines of type D54 in BWR-plants. Corrosion fatigue has also been discovered in at least one type of nuclear turbine. Initiation times have been very long and the varying experiences in different types of turbines may simply reflect differing initiation times. Corrosion fatigue may therefore become more frequent in other types of turbines in the future. The type of water treatment (BWR/PWR) and possibly temperature after reheating seem to influence the risk for corrosion fatigue. Influence of inleakage of cooling water is less clear for these nuclear plants. The long initiation times together with the fact that very few of the cracked blades have actually failed, indicate that the cracks initiate and/or propagate during transients. Extensive laboratory tests show that there are alternative blade materials available with improved resistance against corrosion fatigue, with the most promising being 15/5 PH and A905, together with Ti6Al4V. The Ti alloy shows the best resistance against corrosion fatigue in most environments and is already used in some turbines. Disadvantage is a higher cost and possible need for redesign of the blades. The alternative materials are recommended for use for blades in the transition zone between dry and wet steam in LP turbines. The main disadvantage is a lack of references, even if 15%5 PH has been used to a very limited extent. 40 refs, 24 figs, 12 tabs, 9 appendices

  1. Nissei incas system (FP-Plan) which databased the skilled sense and experiences in molding metal design. Kanagata sekkei ni okeru kan ya keiken wo data base kashita Nissei incas system (FP-plan)

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, K. (Nissei Plastic Industrial Co. Ltd., Nagano (Japan))

    1992-01-01

    Mold System Department of Nissei Resin Industies Co. has developed NISSEI INCAS SYSTEM, which is a CAD/CAM/CAE system specially for injection metal molding. Generally, high analysis methods such as flow analysis method have been considered for CAE, though, when making it to be linked with designing works for injection molding metals, economic conditions will not make a balance. Since authors have judged that to make an accurate mold metal drawing more quickly, before adopting such kind of flow analysis, more inportant and fundamental problems might be remained, they have started to develope their own system called FP-PLAN. This system, for example, is a software, which paying mainly attention to the most important and common problems for molding metal design to be solved, such as setting of shrinking factor, gate and runner design, estimation of cavity inside pressure, etc. Specially, they have developed only small molding products (product volume shall be under 200 cm {sup 3}). In this report, outlines of FP-PLAN such as the characteristics and programs have been intrduced. 4 figs., 2 tabs.

  2. Best estimate analysis of LOFT L2-5 with CATHARE: uncertainty and sensitivity analysis

    Energy Technology Data Exchange (ETDEWEB)

    JOUCLA, Jerome; PROBST, Pierre [Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses (France); FOUET, Fabrice [APTUS, Versailles (France)

    2008-07-01

    The revision of the 10 CFR50.46 in 1988 has made possible the use of best-estimate codes. They may be used in safety demonstration and licensing, provided that uncertainties are added to the relevant output parameters before comparing them with the acceptance criteria. In the safety analysis of the large break loss of coolant accident, it was agreed that the 95. percentile estimated with a high degree of confidence should be lower than the acceptance criteria. It appeared necessary to IRSN, technical support of the French Safety Authority, to get more insight into these strategies which are being developed not only in thermal-hydraulics but in other fields such as in neutronics. To estimate the 95. percentile with a high confidence level, we propose to use rank statistics or bootstrap. Toward the objective of assessing uncertainty, it is useful to determine and to classify the main input parameters. We suggest approximating the code by a surrogate model, the Kriging model, which will be used to make a sensitivity analysis with the SOBOL methodology. This paper presents the application of two new methodologies of how to make the uncertainty and sensitivity analysis on the maximum peak cladding temperature of the LOFT L2-5 test with the CATHARE code. (authors)

  3. LOFT blowdown loop piping thermal analysis Class I review

    International Nuclear Information System (INIS)

    Kinnaman, T.L.

    1978-01-01

    In accordance with ASME Code, Section III requirements, all analyses of Class I components must be independently reviewed. Since the LOFT blowdown loop piping up through the blowdown valve is a Class I piping system, the thermal analyses are reviewed. The Thermal Analysis Branch comments to this review are also included. It is the opinion of the Thermal Analysis Branch that these comments satisfy all of the reviewers questions and that the analyses should stand as is, without additional considerations in meeting the ASME Code requirements and ANC Specification 60139

  4. Precise measurements of neutron capture cross sections for FP

    International Nuclear Information System (INIS)

    Nakamura, Shoji; Harada, Hideo; Katoh, Toshio

    2000-01-01

    The thermal neutron capture cross sections (σ 0 ) and the resonance integrals (I 0 ) of some fission products (FP), such as 137 Cs, 90 Sr, 99 Tc, 129 I and 135 Cs, were measured by the activation and γ-ray spectroscopic methods. Moreover, the cross section measurements were done for other FP elements, such as 127 I, 133 Cs and 134 Cs. This paper provides the summary of the FP cross section measurements, which have been performed by authors. (author)

  5. Evaluating item endorsement rates for the MMPI-2-RF F-r and Fp-r scales across ethnic, gender, and diagnostic groups with a forensic inpatient sample.

    Science.gov (United States)

    Glassmire, David M; Jhawar, Amandeep; Burchett, Danielle; Tarescavage, Anthony M

    2017-05-01

    The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) F(p) (Infrequency-Psychopathology) scale was developed to measure overreporting in a manner that was minimally confounded by genuine psychopathology, which was a problem with using the MMPI-2 F (Infrequency) scale among patients with severe mental illness. Although revised versions of both of these scales are included on the MMPI-2-Restructured Form and used in a forensic context, no item-level research has been conducted on their sensitivity to genuine psychopathology among forensic psychiatric inpatients. Therefore, we examined the psychometric properties of the scales in a sample of 438 criminally committed forensic psychiatric inpatients who were adjudicated as not guilty by reason of insanity and had no known incentive to overreport. We found that 20 of the 21 Fp-r items (95.2%) demonstrated endorsement rates ≤ 20%, with 14 of the items (66.7%) endorsed by less than 10% of the sample. Similar findings were observed across genders and across patients with mood and psychotic disorders. The one item endorsed by more than 20% of the sample had a 23.7% overall endorsement rate and significantly different endorsement rates across ethnic groups, with the highest endorsements occurring among Hispanic/Latino (43.3% endorsement rate) patients. Endorsement rates of F-r items were generally higher than for Fp-r items. At the scale level, we also examined correlations with the Restructured Clinical Scales and found that Fp-r demonstrated lower correlations than F-r, indicating that Fp-r is less associated with a broad range of psychopathology. Finally, we found that Fp-r demonstrated slightly higher specificity values than F-r at all T score cutoffs. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Increased brain temserotoneric transporter availability in adult migraineurs: ([18F]FP-CIT PET imaging pilot study

    International Nuclear Information System (INIS)

    Park, Eun Kyung; Hwang, Yu Mi; Chu, Min Kyung; Jung, Ki Young

    2016-01-01

    Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([18F]FP-CIT) positron emission tomography (PET). Brain [18F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BP ND) of [18F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters. BP ND at the brainstem was significantly higher in adult migraineurs (n = 6, 1.15 ± 0.17) than healthy subjects (0.95 ± 0.14) (p = 0.04). Healthy subjects demonstrated negative correlation between brainstem BP ND and age (r = −0.64, p = 0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP ND (r = 0.66, p = 0.02), when age and duration of illness were corrected. Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [18F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs

  7. Increased brain temserotoneric transporter availability in adult migraineurs: ([18F]FP-CIT PET imaging pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Park, Eun Kyung [Dept. of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul (Korea, Republic of); Hwang, Yu Mi [Center for Research Information, Korea University, Seoul (Korea, Republic of); Chu, Min Kyung [Dept. of Neurology, Sacred Heart Hospital, Hallym University College of Medicine, Anyang (Korea, Republic of); Jung, Ki Young [Dept. of Neurology, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2016-03-15

    Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([18F]FP-CIT) positron emission tomography (PET). Brain [18F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BP ND) of [18F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters. BP ND at the brainstem was significantly higher in adult migraineurs (n = 6, 1.15 ± 0.17) than healthy subjects (0.95 ± 0.14) (p = 0.04). Healthy subjects demonstrated negative correlation between brainstem BP ND and age (r = −0.64, p = 0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP ND (r = 0.66, p = 0.02), when age and duration of illness were corrected. Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [18F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.

  8. ChLpMab-23: Cancer-Specific Human-Mouse Chimeric Anti-Podoplanin Antibody Exhibits Antitumor Activity via Antibody-Dependent Cellular Cytotoxicity.

    Science.gov (United States)

    Kaneko, Mika K; Nakamura, Takuro; Kunita, Akiko; Fukayama, Masashi; Abe, Shinji; Nishioka, Yasuhiko; Yamada, Shinji; Yanaka, Miyuki; Saidoh, Noriko; Yoshida, Kanae; Fujii, Yuki; Ogasawara, Satoshi; Kato, Yukinari

    2017-06-01

    Podoplanin is expressed in many cancers, including oral cancers and brain tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in cancer metastasis and tumor malignancy. We previously established many monoclonal antibodies (mAbs) against human podoplanin using the cancer-specific mAb (CasMab) technology. LpMab-23 (IgG 1 , kappa), one of the mouse anti-podoplanin mAbs, was shown to be a CasMab. However, we have not shown the usefulness of LpMab-23 for antibody therapy against podoplanin-expressing cancers. In this study, we first determined the minimum epitope of LpMab-23 and revealed that Gly54-Leu64 peptide, especially Gly54, Thr55, Ser56, Glu57, Asp58, Arg59, Tyr60, and Leu64 of podoplanin, is a critical epitope of LpMab-23. We further produced human-mouse chimeric LpMab-23 (chLpMab-23) and investigated whether chLpMab-23 exerts antibody-dependent cellular cytotoxicity (ADCC) and antitumor activity. In flow cytometry, chLpMab-23 showed high sensitivity against a podoplanin-expressing glioblastoma cell line, LN319, and an oral cancer cell line, HSC-2. chLpMab-23 also showed ADCC activity against podoplanin-expressing CHO cells (CHO/podoplanin). In xenograft models with HSC-2 and CHO/podoplanin, chLpMab-23 exerts antitumor activity using human natural killer cells, indicating that chLpMab-23 could be useful for antibody therapy against podoplanin-expressing cancers.

  9. Genetics, structure, and prevalence of FP967 (CDC Triffid) T-DNA in flax.

    Science.gov (United States)

    Young, Lester; Hammerlindl, Joseph; Babic, Vivijan; McLeod, Jamille; Sharpe, Andrew; Matsalla, Chad; Bekkaoui, Faouzi; Marquess, Leigh; Booker, Helen M

    2015-01-01

    The detection of T-DNA from a genetically modified flaxseed line (FP967, formally CDC Triffid) in a shipment of Canadian flaxseed exported to Europe resulted in a large decrease in the amount of flax planted in Canada. The Canadian flaxseed industry undertook major changes to ensure the removal of FP967 from the supply chain. This study aimed to resolve the genetics and structure of the FP967 transfer DNA (T-DNA). The FP967 T-DNA is thought to be inserted in at single genomic locus. The junction between the T-DNA and genomic DNA consisted of two inverted Right Borders with no Left Border (LB) flanking genomic DNA sequences recovered. This information was used to develop an event-specific quantitative PCR (qPCR) assay. This assay and an existing assay specific to the T-DNA construct were used to determine the genetics and prevalence of the FP967 T-DNA. These data supported the hypothesis that the T-DNA is present at a single location in the genome. The FP967 T-DNA is present at a low level (between 0.01 and 0.1%) in breeder seed lots from 2009 and 2010. None of the 11,000 and 16,000 lines selected for advancement through the Flax Breeding Program in 2010 and 2011, respectively, tested positive for the FP967 T-DNA, however. Most of the FP967 T-DNA sequence was resolved via PCR cloning and next generation sequencing. A 3,720 bp duplication of an internal portion of the T-DNA (including a Right Border) was discovered between the flanking genomic DNA and the LB. An event-specific assay, SAT2-LB, was developed for the junction between this repeat and the LB.

  10. Lp-dual affine surface area forms of Busemann–Petty type problems

    Indian Academy of Sciences (India)

    Associated with the notion of Lp-intersection body which was defined ... Lp-dual affine surface area; Lp-intersection body; Busemann–Petty ..... [11] Schneider R, Convex Bodies: The Brunn–Minkowski Theory (1993) (Cambridge: Cam-.

  11. The obesity and fatty liver are reduced by plant-derived Pediococcus pentosaceus LP28 in high fat diet-induced obese mice.

    Directory of Open Access Journals (Sweden)

    Xingrong Zhao

    Full Text Available We evaluated the effect of an oral administration of a plant-derived lactic acid bacterium, Pediococcus pentosaceus LP28 (LP28, on metabolic syndrome by using high fat diet-induced obese mice. The obese mice were divided into 2 groups and fed either a high fat or regular diet for 8 weeks. Each group was further divided into 3 groups, which took LP28, another plant-derived Lactobacillus plantarum SN13T (SN13T or no lactic acid bacteria (LAB. The lean control mice were fed a regular diet without inducing obesity prior to the experiment. LP28 reduced body weight gain and liver lipid contents (triglyceride and cholesterol, in mice fed a high fat diet for 8 weeks (40%, 54%, and 70% less than those of the control group without LAB, and P = 0.018, P<0.001, and P = 0.021, respectively, whereas SN13T and the heat treated LP28 at 121°C for 15 min were ineffective. Abdominal visceral fat in the high fat diet mice fed with LP28 was also lower than that without LAB by 44%, although it was not significant but borderline (P = 0.076. The sizes of the adipocytes and the lipid droplets in the livers were obviously decreased. A real-time PCR analyses showed that lipid metabolism-related genes, such as CD36 (P = 0.013, SCD1 encoding stearoyl-CoA desaturase 1 (not significant but borderline, P = 0.066, and PPARγ encoding peroxisome proliferator-activated receptor gamma (P = 0.039, were down-regulated by taking LP28 continuously, when compared with those of the control group. In conclusion, LP28 may be a useful LAB strain for the prevention and reduction of the metabolic syndrome.

  12. Theoretical spectroscopy and the fp shell

    International Nuclear Information System (INIS)

    Poves, A.; Zuker, A.

    1980-01-01

    The recently developed quasiconfiguration method is applied to fp shell nuclei. Second order degenerate perturbation theory is shown to be sufficient to produce, for low lying states, the same results as large diagonalizations in the f(7/2)p(3/2)p(1/2)f(5/2)sup(n) full space. due to the operation of linked cluster mechanisms. Realistic interactions with minimal monopole changes are shown to be successful in reproducing spectra, binding energies, quadrupole moments and transition rates. Large shell model spaces are seen to exhibit typical many body behaviour. Quasiconfigurations allow insight into the underlying coupling schemes

  13. A new LP formulation of the admission control problem modelled as an MDP under average reward criterion

    Science.gov (United States)

    Pietrabissa, Antonio

    2011-12-01

    The admission control problem can be modelled as a Markov decision process (MDP) under the average cost criterion and formulated as a linear programming (LP) problem. The LP formulation is attractive in the present and future communication networks, which support an increasing number of classes of service, since it can be used to explicitly control class-level requirements, such as class blocking probabilities. On the other hand, the LP formulation suffers from scalability problems as the number C of classes increases. This article proposes a new LP formulation, which, even if it does not introduce any approximation, is much more scalable: the problem size reduction with respect to the standard LP formulation is O((C + 1)2/2 C ). Theoretical and numerical simulation results prove the effectiveness of the proposed approach.

  14. [O-methyl-{sup 11}C]{beta}-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: Preparation, autoradiography, metabolite studies, and positron emission tomography examinations

    Energy Technology Data Exchange (ETDEWEB)

    Lundkvist, Camilla; Halldin, Christer; Swahn, Carl-Gunnar; Hall, Haakan; Karlsson, Per; Nakashima, Yoshifumi; Wang, Shaoyin; Milius, Richard A.; Neumeyer, John L.; Farde, Lars

    1995-10-01

    {beta}-CIT-FP [N-(3-fluoropropyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)nortropane] is a cocaine analogue with a high affinity for the dopamine transporter. [O-methyl-{sup 11}C]{beta}-CIT-FP ([{sup 11}C]{beta}-CIT-FP) was prepared byO -alkylation of the free acid with [{sup 11}C]methyl iodide. The total radiochemical yield of [{sup 11}C]{beta}-CIT-FP was 50 to 60% with an overall synthesis time of 30 min. The radiochemical purity was >99%, and the specific radioactivity at time of injection was about 37 GBq/{mu}mol (1000 Ci/mmol). Autoradiographic examination of [{sup 11}C]{beta}-CIT-FP binding in human brain postmortem demonstrated specific binding in the caudate nucleus and putamen. Positron emission tomography (PET) examination of [{sup 11}C]{beta}-CIT-FP in a Cynomolgus monkey demonstrated accumulation in the striatum with a striatum-to-cerebellum ratio of about 8 after 60 min. Equilibrium in the striatum was attained within 70 to 90 min. The radioactivity ratios of thalamus/cerebellum and neocortex/cerebellum were about 2 and 1.5, respectively. In a displacement experiment, radioactivity in the striatum but not in the cerebellum was reduced after injection of {beta}-CIT, indicating that striatal radioactivity following injection of [{sup 11}C]{beta}-CIT-FP is associated with dopamine transporter sites and that the binding is reversible. The fraction of the total radioactivity in plasma representing [{sup 11}C]{beta}-CIT-FP determined by high-performance liquid chromatography (HPLC) was 84% at 15 min and 50% at 95 min. [{sup 11}C]{beta}-CIT-FP should be a useful PET radioligand for the quantitation of dopamine transporters in the human brain in vivo.

  15. Background simulations for the Large Area Detector onboard LOFT

    DEFF Research Database (Denmark)

    Campana, Riccardo; Feroci, Marco; Ettore, Del Monte

    2013-01-01

    and magnetic fields around compact objects and in supranuclear density conditions. Having an effective area of similar to 10 m(2) at 8 keV, LOFT will be able to measure with high sensitivity very fast variability in the X-ray fluxes and spectra. A good knowledge of the in-orbit background environment...... is essential to assess the scientific performance of the mission and optimize the design of its main instrument, the Large Area Detector (LAD). In this paper the results of an extensive Geant-4 simulation of the instrumentwillbe discussed, showing the main contributions to the background and the design...... an anticipated modulation of the background rate as small as 10 % over the orbital timescale. The intrinsic photonic origin of the largest background component also allows for an efficient modelling, supported by an in-flight active monitoring, allowing to predict systematic residuals significantly better than...

  16. Results and exploitation of FP-4 and FP-5 research in the area 'Safety of existing installations'. Part II

    International Nuclear Information System (INIS)

    Goethem, G. van; Zurita, A.; Manolatos, P.; Casalta, S.

    2004-01-01

    An overview is given of the most important achievements of the research programme co-financed by the European Union (EU) in the area of LWR safety over the FP-4 and FP-5 periods from the end-users point of view. The end-users are: the contracting organisations (i.e. utilities and associated engineering companies, regulatory bodies and associated technical safety organisations, manufacturing industry and associated services), the non-contracting organisations (including decision makers and opinion leaders) and the European Commission. Besides Community research strategy and programme implementation aspects in general, this paper is focusing on the S/T achievements obtained by multi-partner projects in the - 7 clusters of multi-partner projects in Euratom FP-4 (1994-1998): AGE for structural ageing, INV and EXV for in-vessel core degradation and ex-vessel molten corium coolability, ST for radiological source term, CONT for containment integrity, AMM for accident management measures and INNO for innovative safety features - the total cost of the 67 multipartner projects comprised in this Community research was Euro 71.3 million, out of which Euro 35.9 million was contributed by the EU budget - 3 clusters of multi-partner projects in Euratom FP-5 (1998-2002): PLEM for plant life extension and management; SAM for severe accident management and EVOL for evolutionary safety concepts - the total cost of the 71 multipartner projects comprised in this Community research is Euro 85.4 million, out of which Euro 43.5 million is contributed by the EU budget. The objectives of this Community research are discussed and a number of FP-4 and FP-5 projects are selected to demonstrate to what extent the proposed objectives were indeed met. Besides technological requirements, socio-economic aspects are becoming increasingly important due to the level of public and political acceptance and to the economic pressure of deregulated electricity markets; this is also discussed. Finally the

  17. Strategic planning for minimizing CO2 emissions using LP model based on forecasted energy demand by PSO Algorithm and ANN

    Energy Technology Data Exchange (ETDEWEB)

    Yousefi, M.; Omid, M.; Rafiee, Sh. [Department of Agricultural Machinery Engineering, University of Tehran, Karaj (Iran, Islamic Republic of); Ghaderi, S. F. [Department of Industrial Engineering, University of Tehran, Tehran (Iran, Islamic Republic of)

    2013-07-01

    Iran's primary energy consumption (PEC) was modeled as a linear function of five socioeconomic and meteorological explanatory variables using particle swarm optimization (PSO) and artificial neural networks (ANNs) techniques. Results revealed that ANN outperforms PSO model to predict test data. However, PSO technique is simple and provided us with a closed form expression to forecast PEC. Energy demand was forecasted by PSO and ANN using represented scenario. Finally, adapting about 10% renewable energy revealed that based on the developed linear programming (LP) model under minimum CO2 emissions, Iran will emit about 2520 million metric tons CO2 in 2025. The LP model indicated that maximum possible development of hydropower, geothermal and wind energy resources will satisfy the aim of minimization of CO2 emissions. Therefore, the main strategic policy in order to reduce CO2 emissions would be exploitation of these resources.

  18. LOFT liquid level transducer application techniques and measurement uncertainty

    International Nuclear Information System (INIS)

    Batt, D.L.; Biladeau, G.L.; Goodrich, L.D.; Nightingale, C.M.

    1979-01-01

    A conductivity sensitive liquid level transducer (LLT) has been designed and used successfully for determining whether steam or water is present in the Loss-of-Fluid Tests (LOFT) performed by EG and G Idaho, Inc., at the Idaho National Engineering Laboratory. The presence of steam or water is determined by establishing a discriminator level which is set manually. A computer program establishes the presence or absence of water for each data point taken. In addition to liquid level, the LLT is used for reactor vessel mass and volume calculations. The uncertainty in the liquid level is essentially the spacing of the LLT electrodes

  19. LEP dominates LP-HEP

    Energy Technology Data Exchange (ETDEWEB)

    Fraser, Gordon

    1991-09-15

    CERN's LEP electron-positron collider was the star of this year's major physics meeting - the Joint International Lepton-Photon Symposium and Europhysics Conference on High Energy Physics (LP-HEP) - held in Geneva from 25 July - 1 August.

  20. Pressure sensor for use in the Loss-of-Fluid-Test (LOFT) reactor

    International Nuclear Information System (INIS)

    Billeter, T.R.

    1979-07-01

    Tests at temperatures up to 800 0 F and pressures up to 2500 psig were conducted at Hanford Engineering Development Laboratory (HEDL) to qualify an instrument for measurement of fuel-rod pressure in the Loss-of-Fluid-Test (LOFT) reactor. Operational characteristics of the selected pressure transducers are summarized for a series of static, quasi-static, and transient tests conducted for a period of about 700 hours

  1. The use of Monte-Carlo simulation and order statistics for uncertainty analysis of a LBLOCA transient (LOFT-L2-5)

    International Nuclear Information System (INIS)

    Chojnacki, E.; Benoit, J.P.

    2007-01-01

    tolerance limits for any code results. A proof and an extension of this statistical theorem will be given. From this proof, it will appear easily why the use of order statistics results requires the Simple Random Sampling method (SRS). The second aim of this paper is to illustrate the benefit of these techniques from the application of the IRSN uncertainty methodology on the transient LOFT-L2-5. To achieve this aim, we will use the results obtained in the frame of our participation to the BEMUSE program to clarify how to perform and analyse a Monte-Carlo simulation. In particular, it will be shown how order statistics provide valuable results for estimating percentiles of relevant safety quantities. Finally, from our experience gained during BEMUSE project, we will conclude on the applicability of Monte-Carlo simulation to derive uncertainty ranges for safety purposes. (authors)

  2. 78 FR 45592 - DeltaPoint Capital IV, LP;

    Science.gov (United States)

    2013-07-29

    ..., Suite 160, Pittsford, NY 14534. The financing was contemplated for working capital. The financing is... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662] DeltaPoint Capital IV, LP; Notice Seeking... given that DeltaPoint Capital IV, L.P., 45 East Avenue, 6th Floor, Rochester, NY 14604, Federal...

  3. The LOFT perspective on neutron star thermonuclear bursts: White paper in support of the mission concept of the large observatory for X-ray timing

    Energy Technology Data Exchange (ETDEWEB)

    in' t Zand, J. J.M. [SRON Netherlands Institute for Space Research, Utrecht (The Netherlands); Malone, Christopher M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Altamirano, D. [Univ. of Southampton, Southampton (United Kingdom); Ballantyne, D. R. [Georgia Inst. of Technology, Atlanta, GA (United States); Bhattacharyya, S. [Tata Institute of Fundamental Research, Mumbai (India); Brown, E. F. [Michigan State Univ., East Lansing, MI (United States); Cavecchi, Y. [Univ. of Amsterdam, Amsterdam (The Netherlands); Chakrabarty, D. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Chenevez, J. [Technical Univ. of Denmark, Lyngby (Denmark); Cumming, A. [McGill Univ., Montreal, QC (Canada); Degenaar, N. [Univ. of Cambridge, Cambridge (United Kingdom); Falanga, M. [International Space Science Institute, Bern (Switzerland); Galloway, D. K. [Monash Univ., VIC (Australia); Heger, A. [Monash Univ., VIC (Australia); Jose, J. [Univ. Politecnica de Catalunya, Barcelona (Spain); Institut d' Estudis Espacials de Catalunya, Barcelona (Spain); Keek, L. [Georgia Institute of Technology, Atlanta, GA (United States); Linares, M. [Univ. de La Laguna, Tenerife (Spain); Mahmoodifar, S. [Univ. of Maryland, College Park, MD (United States); Mendez, M. [Univ. of Groningen, Groningen (The Netherlands); Miller, M. C. [Univ. of Maryland, College Park, MD (United States); Paerels, F. B. S. [Columbia Astrophysics Lab., New York, NY (United States); Poutanen, J. [Univ. of Turku, Piikkio (Finland); Rozanska, A. [N. Copernicus Astronomical Center PAS, Warsaw (Poland); Schatz, H. [National Superconducting Cyclotron Laboratory at Michigan State University; Serino, M. [Institute of Physical and Chemical Research (RIKEN); Strohmayer, T. E. [NASA' s Goddard Space Flight Center, Greenbelt, MD (United States); Suleimanov, V. F. [Univ. Tubingen, Tubingen (Germany); Thielemann, F. -K. [Univ. Basel, Basel (Switzerland); Watts, A. L. [Univ. of Amsterdam, Amsterdam (The Netherlands); Weinberg, N. N. [Massachusetts Institute of Technology, Cambridge, MA (United States); Woosley, S. E. [Univ. of California, Santa Cruz, CA (United States); Yu, W. [Chinese Academy of Sciences (CAS), Shanghai (China); Zhang, S. [Institute of High-Energy Physics, Beijing (China); Zingale, M. [Stony Brook Univ., Stony Brook, NY (United States)

    2015-01-14

    The Large Area Detector (LAD) on the Large Observatory For X-ray Timing ( LOFT ), with a 8.5 m 2 photon- collecting area in the 2–30 keV bandpass at CCD-class spectral resolving power (λ/Δλ = 10 – 100), is designed for optimum performance on bright X-ray sources. Thus, it is well-suited to study thermonuclear X-ray bursts from Galactic neutron stars. These bursts will typically yield 2 x 105 photon detections per second in the LAD, which is at least 15 times more than with any other instrument past, current or anticipated. The Wide Field Monitor (WFM) foreseen for LOFT uniquely combines 2–50 keV imaging with large (30%) prompt sky coverage. This will enable the detection of tens of thousands of thermonuclear X-ray bursts during a 3-yr mission, including tens of superbursts. Both numbers are similar or more than the current database gathered in 50 years of X-ray astronomy.

  4. Anti-soluble liver antigen/liver-pancreas (SLA/LP) antibodies in pediatric patients with autoimmune hepatitis.

    Science.gov (United States)

    Vitozzi, Susana; Djilali-Saiah, Idriss; Lapierre, Pascal; Alvarez, Fernando

    2002-12-01

    Antibodies against soluble liver antigen/liver-pancreas (SLA/LP) have been associated with severe autoimmune hepatitis (AIH) and poor outcome, but most of these reports have focused on adult patients. The aim of this study was to assess the prevalence and clinical significance of anti-SLA/LP antibodies in a pediatric population with AIH. We developed a quantitative enzyme-linked immunoassay (ELISA), a Western blot (WB) and an immunoprecipitation assay (IPA) based on recombinant cDNA from activated Jurkat cells. The specificity of these tests was validated by testing 200 serum samples from healthy subjects, and from patients with liver and non-liver diseases. Anti-SLA/LP antibodies were found in patients with type 1 and type 2 AIH. The prevalence of these antibodies in patients with type 1 AIH was: 42% when tested by ELISA, 15% by WB and 50% by IPA. In patients with type 2 AIH, the prevalence rates were 42% by ELISA, 18% by WB and 44% by IPA. The mean titer values for anti-SLA/LP antibodies was significantly higher in type 2 AIH (1:1,300 +/- 339) than in type 1 AIH (1:600 +/- 71; p LKM1) and anti-liver cytosol type 1 (LC1) antibodies in sera. The presence of anti-SLA/LP showed a significant female preponderance in type 1 and 2 AIH patients (p = 0.0003 and p = 0.003, respectively), and was significantly correlated with a lower age at diagnosis (p = 0.05) in type 1 AIH patients. In conclusion, anti-SLA/LP antibodies in pediatric patients are associated with both type 1 and 2 AIH.

  5. Sparse Adaptive Channel Estimation Based on lp-Norm-Penalized Affine Projection Algorithm

    Directory of Open Access Journals (Sweden)

    Yingsong Li

    2014-01-01

    Full Text Available We propose an lp-norm-penalized affine projection algorithm (LP-APA for broadband multipath adaptive channel estimations. The proposed LP-APA is realized by incorporating an lp-norm into the cost function of the conventional affine projection algorithm (APA to exploit the sparsity property of the broadband wireless multipath channel, by which the convergence speed and steady-state performance of the APA are significantly improved. The implementation of the LP-APA is equivalent to adding a zero attractor to its iterations. The simulation results, which are obtained from a sparse channel estimation, demonstrate that the proposed LP-APA can efficiently improve channel estimation performance in terms of both the convergence speed and steady-state performance when the channel is exactly sparse.

  6. LEP dominates LP-HEP

    International Nuclear Information System (INIS)

    Fraser, Gordon

    1991-01-01

    CERN's LEP electron-positron collider was the star of this year's major physics meeting - the Joint International Lepton-Photon Symposium and Europhysics Conference on High Energy Physics (LP-HEP) - held in Geneva from 25 July - 1 August

  7. LP 543-25: A Rare Low-mass Runaway Disk Star

    Science.gov (United States)

    de la Fuente Marcos, Raúl; de la Fuente Marcos, Carlos

    2018-05-01

    LP 543-25 or PSS 544-7 is a high proper-motion star located 458 pc from the Sun in the constellation of Canis Minor; it has been argued that it could be a candidate cannonball star ejected by a star cluster. Here, we revisit the issue of the kinematics of this interesting star using Gaia DR2. The heliocentric Galactic velocity components are (U, V, W) = (206, -289, 30) km/s; the corresponding Galactocentric Galactic velocity components show that LP 543-25 is moving in the Galactic plane and away from the Galactic Center at a rate of nearly 200 km/s, which is compatible with an origin in one of the multiple star clusters that inhabit the inner regions of the Milky Way. LP 543-25 appears to be a member of an elusive class of stars, the low-mass runaway stars. It is perhaps one of the closest and less massive runaway stars identified so far.

  8. Strategic planning for minimizing CO2 emissions using LP model based on forecasted energy demand by PSO Algorithm and ANN

    Energy Technology Data Exchange (ETDEWEB)

    Yousefi, M.; Omid, M.; Rafiee, Sh. [Department of Agricultural Machinery Engineering, University of Tehran, Karaj (Iran, Islamic Republic of); Ghaderi, S.F. [Department of Industrial Engineering, University of Tehran, Tehran (Iran, Islamic Republic of)

    2013-07-01

    Iran's primary energy consumption (PEC) was modeled as a linear function of five socioeconomic and meteorological explanatory variables using particle swarm optimization (PSO) and artificial neural networks (ANNs) techniques. Results revealed that ANN outperforms PSO model to predict test data. However, PSO technique is simple and provided us with a closed form expression to forecast PEC. Energy demand was forecasted by PSO and ANN using represented scenario. Finally, adapting about 10% renewable energy revealed that based on the developed linear programming (LP) model under minimum CO2 emissions, Iran will emit about 2520 million metric tons CO2 in 2025. The LP model indicated that maximum possible development of hydropower, geothermal and wind energy resources will satisfy the aim of minimization of CO2 emissions. Therefore, the main strategic policy in order to reduce CO2 emissions would be exploitation of these resources.

  9. Diagnostic value of CRP and Lp(a) in coronary heart disease.

    Science.gov (United States)

    Erbağci, Ayşe Binnur; Tarakçioğlu, Mehmet; Aksoy, Mehmet; Kocabaş, Ramazan; Nacak, Muradiye; Aynacioğlu, A Sükrü; Sivrikoz, Cumhur

    2002-06-01

    Increased lipoprotein (a) [Lp(a)] concentration was reported to be an independent risk factor for coronary heart disease (CHD). Recent epidemiological studies affirmed the value of C-reactive protein (CRP) as the strongest, univariate predictor of the cardiovascular events. We decided to establish cut-off levels providing maximum diagnostic efficiency for CHD. In this study we measured CRP and Lp(a) concentrations in patients with angiographically demonstrated CHD (group A, n: 120), patients without any angiographically demonstrable lesion (group B, n: 62) and a group of healthy subjects (group C, n: 41). Data were evaluated correcting for lipid and lipoprotein concentrations, diabetes mellitus, hypertension, smoking, age, and body mass index in men and women. ROC curve based cut-off values (comparing group A versus groups B and C) and associated diagnostic performances of the assays were evaluated. Significant increases were noted in serum CRP concentrations in men and women, in groups A vs. B,A vs. C, B vs. C. Lp(a) concentrations were not different among groups in men but were higher in group A vs. B and C in women. Optimal cut-off levels for CRP in women and men were found as 2.1 and 3.0 mg/l with the diagnostic values of 0.792 and 0.770, respectively. For Lp(a) optimal cut-off levels were found as 22.6 and 9.8 mg/dl with the diagnostic values of 0.612 and 0.596 in women and men, respectively. The CRP level is quite efficient for separation of patients from controls. Therefore keeping in mind the lack of specificity, the CRP level may be a useful tool in the diagnosis of coronary heart disease. However, the Lp(a) level is not efficient enough to support the use of Lp(a) measurement for management of coronary heart disease.

  10. Experiment data report for semiscale MOD-1 test S-01-3 (isothermal blowdown with core resistance simulator)

    International Nuclear Information System (INIS)

    Zender, S.N.

    1975-03-01

    Recorded test data are presented for Test S-01-3 of the semiscale Mod-1 isothermal blowdown test series. Test S-01-3 is one of several semiscale Mod-1 experiments which are counterparts of the planned Loss-of-Fluid Test (LOFT) nonnuclear experiments. System hardware is of the LOFT design, selected using volumetric scaling methods, and initial conditions duplicate those identified for the LOFT nonnuclear tests. Test S-01-3 employed an intact loop resistance that was low relative to that of the first test in the series (Test S-01-2) to establish the importance of intact loop resistance on system response during blowdown. An orificed structure was used in the pressure vessel to simulate the LOFT core simulator. The test was initiated at isothermal conditions of 2245 psig and 538 0 F by a simulated offset shear of the cold-leg broken loop piping. During system depressurization, coolant was injected into the lower plenum of the pressure vessel to provide data on the effects of emergency core cooling on system response. Additionally, to aid in determination of the effects of accumulator gas on pressure suppression system response, the nitrogen used to charge the accumulator systems for Test S-01-3 was allowed to vent into the lower plenum following depletion of the coolant. (U.S.)

  11. Integrating theory and data to create an online self-management programme for adults with type 2 diabetes: HeLP-Diabetes

    Directory of Open Access Journals (Sweden)

    Kingshuk Pal

    2015-10-01

    This protocol demonstrates a multi-disciplinary approach to combining evidence from multiple sources to create ’HeLP-Diabetes’: a theory and evidence based online self-management intervention for adults with type 2 diabetes.

  12. FP-4 and FP-5 Euratom research activities in the field of plant life management

    International Nuclear Information System (INIS)

    Lemaitre, P.; Goethem, G. van

    2001-01-01

    In this paper an overview is given of the European Union (EU) Euratom research conducted through shared cost and concerted actions in the field of plant life management. After a general introduction on the organisation of the research framework programmes the achievements of the 4th framework programme (FP-4/1994-1998) and the activities under the 5th framework programme (FP-5/1999-2002) in the field of plant life management are presented and discussed in detail. Besides technological safety requirements, socio-economic aspects are becoming increasingly important due to the level of public and political acceptance and to the economic pressure of deregulated electricity markets. It is shown that research conducted in the Euratom framework may contribute to meet these requirements, thereby maintaining nuclear power as a competitive and sustainable option for the energy policy of the European Union. (author)

  13. PuLP/XtraPuLP : Partitioning Tools for Extreme-Scale Graphs

    Energy Technology Data Exchange (ETDEWEB)

    2017-09-21

    PuLP/XtraPulp is software for partitioning graphs from several real-world problems. Graphs occur in several places in real world from road networks, social networks and scientific simulations. For efficient parallel processing these graphs have to be partitioned (split) with respect to metrics such as computation and communication costs. Our software allows such partitioning for massive graphs.

  14. CORN, LP Goldfield Approval

    Science.gov (United States)

    This November 19, 2015 letter from EPA approves the petition from CORN, LP, Goldfield facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS pro

  15. Synthesis and quality control of 18F-β-FP-CIT as a dopamine transporter imaging agent

    International Nuclear Information System (INIS)

    Tang Ganghua; Tang Xiaolan; Wang Mingfang; Huang Zuhan

    2002-01-01

    Objective: To develop 18 F-N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane ( 18 F-β-FP-CIT) as dopamine transporter imaging agent. Methods: The labelling of 18 F-β-FP-CIT was performed via a two-step synthesis. The 18 F-fluoropropyl bromide was prepared through a nucleophilic substitution by the use of the aminopolyether potassium complex (K/K222) +18 F - as a phase-transfer reagent, and then by N-fluoroalkylation of 2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane (nor-β-CIT) with 18 F-fluoropropyl bromide the 18 F-β-FP-CIT was formed. Contents and analytical methods of quality control for 18 F-β-FP-CIT were investigated and the main quality criteria were achieved through strict control of the determining parameters by standard procedures. Results: The mean overall radiochemical yield from starting 18 F-fluoride was about 8%, the total radiochemical synthesis time was about 90-110 min, and the radiochemical purity was better than 99% by HPLC and TLC. Tests on sterility and apyrogenicity of 18 F-β-FP-CIT obtained by standard procedures were negative, and tests on other main quality criteria met the requirements of the local pharmacopoeia. Conclusion: 18 F-β-FP-CIT injection can be used in the animal and human PET study

  16. Contribution of the mathematical modelling of knowledge to the evaluation of uncertainty margins of a LBLOCA transient (LOFT-L2-5)

    International Nuclear Information System (INIS)

    Baccou, J.; Chojnacki, E.

    2007-01-01

    This work is devoted to some recent developments in uncertainty analysis of the computer code responses used for accident management procedures in nuclear industry. The classical probabilistic approach to evaluate uncertainties is recalled. In this case, the statistical treatment of the code responses is based on the use of order statistics. It provides direct estimations of relevant statistical measures for safety studies. However, the lack of knowledge about uncertainty sources can deteriorate the decision-making. To respect the real state of knowledge, a second model, based on the Dempster-Shafer theory is introduced. It allows to mix the probabilistic approach with the possibility theory that is more appropriate when few information is available. An application of both methodologies to the uncertainty analysis of a LBLOCA transient (LOFT-L2-5) is given

  17. FP-LAPW Calculations of the EFG at Cd Impurities in Rutile SnO2

    International Nuclear Information System (INIS)

    Errico, L. A.; Fabricius, G.; Renteria, M.

    2001-01-01

    We report an ab initio study of the electric-field gradient (EFG) at Cd impurities located at the cation site in the semiconductor SnO 2 (rutile phase). The study was performed with the WIEN97 implementation of the FP-LAPW method. In order to simulate the diluted Cd-impurity in the SnO 2 host and to calculate the electronic structure of the system we used a 72-atoms super-cell, studying the relaxation introduced by the impurity in the lattice. The free-relaxation process performed shows that the relaxations of the oxygen nearest-neighbors of the impurity are not isotropic. Our prediction for the EFG tensor are compared with experimental results and point-charge model predictions

  18. "1"2"3I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies

    International Nuclear Information System (INIS)

    Kasanuki, Koji; Iseki, Eizo; Ota, Kazumi; Kondo, Daizo; Sato, Kiyoshi; Ichimiya, Yosuke; Arai, Heii

    2017-01-01

    Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the "1"2"3I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance. We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in "1"8F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of "1"2"3I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups. Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB. "1"2"3I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway. (orig.)

  19. osFP: a web server for predicting the oligomeric states of fluorescent proteins.

    Science.gov (United States)

    Simeon, Saw; Shoombuatong, Watshara; Anuwongcharoen, Nuttapat; Preeyanon, Likit; Prachayasittikul, Virapong; Wikberg, Jarl E S; Nantasenamat, Chanin

    2016-01-01

    Currently, monomeric fluorescent proteins (FP) are ideal markers for protein tagging. The prediction of oligomeric states is helpful for enhancing live biomedical imaging. Computational prediction of FP oligomeric states can accelerate the effort of protein engineering efforts of creating monomeric FPs. To the best of our knowledge, this study represents the first computational model for predicting and analyzing FP oligomerization directly from the amino acid sequence. After data curation, an exhaustive data set consisting of 397 non-redundant FP oligomeric states was compiled from the literature. Results from benchmarking of the protein descriptors revealed that the model built with amino acid composition descriptors was the top performing model with accuracy, sensitivity and specificity in excess of 80% and MCC greater than 0.6 for all three data subsets (e.g. training, tenfold cross-validation and external sets). The model provided insights on the important residues governing the oligomerization of FP. To maximize the benefit of the generated predictive model, it was implemented as a web server under the R programming environment. osFP affords a user-friendly interface that can be used to predict the oligomeric state of FP using the protein sequence. The advantage of osFP is that it is platform-independent meaning that it can be accessed via a web browser on any operating system and device. osFP is freely accessible at http://codes.bio/osfp/ while the source code and data set is provided on GitHub at https://github.com/chaninn/osFP/.Graphical Abstract.

  20. A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants.

    Science.gov (United States)

    Martinon-Torres, Federico; Gimenez-Sanchez, Francisco; Bernaola-Iturbe, Enrique; Diez-Domingo, Javier; Jiang, Qin; Perez, John L

    2014-09-08

    Neisseria meningitidis serogroup B (MnB) is a major cause of invasive meningococcal disease in infants. A conserved, surface-exposed lipoprotein, LP2086 (a factor H-binding protein [fHBP]), is a promising MnB vaccine target. A bivalent, recombinant vaccine targeting the fHBP (rLP2086) of MnB was developed. This phase 1/2 clinical study was designed to assess the immunogenicity, safety, and tolerability of a 4-dose series of the rLP2086 vaccine at 20-, 60-, 120-, or 200-μg dose levels in vaccine-naive infants when given with routine childhood vaccines. The study was to consist of two phases: a single-blind sentinel phase and an open-label full enrollment phase. During the sentinel phase, randomization of subjects to the next higher dose was delayed pending a 14-day safety review of dose 1 of the preceding dose cohort. The full enrollment phase was to occur after completion of the sentinel phase. Local reactions were generally mild and adverse events infrequent; however, after only 46 infants were randomized into the study, fever rates were 64% and 90% in subjects receiving one 20- or 60-μg rLP2086 dose, respectively. Most fevers were group and 1 subject in the 60-μg group experienced fevers >39.0°C; no fevers were >40.0°C. Due to these high fever rates, the study was terminated early. No immunogenicity data were collected. This report discusses the safety and acceptability of rLP2086 in infants after one 20- or 60-μg dose. Due to the high fever rate experienced in the 20- and 60-μg groups, rLP2086 in the current formulation may not be acceptable for infants. Copyright © 2014. Published by Elsevier Ltd.

  1. Amplitude and Recurrence Time of LP activity at Mt. Etna, Italy

    Science.gov (United States)

    Cauchie, Léna; Saccorotti, Gilberto; Bean, Christopher

    2013-04-01

    The manifestation of Long-Period (LP) activity is attested on many volcanoes worldwide and is thought to be associated with the resonant oscillations of subsurface, fluid-filled, cracks and conduits. Nonetheless the actual source mechanism that originates the resonance is still unclear. Different models have been proposed so far, including (i) fluid flow instabilities as periodic degassing and (ii) brittle failure in viscous magmas. Since LP activity usually precedes and accompanies volcanic eruption, the understanding of these sources is crucial for the hazard assessment and eruption early warning. The work is aimed at improving the understanding of the LP source mechanism through a statistical analysis of detailed LP catalogues. The behaviour of LP activity is compared with the empirical laws governing earthquakes recurrence (e.g., Gutenberg-Richter [GR] and Gamma-law distributions), in order to understand what relationships, if any, exist between these two apparently different earthquake classes. In particular, about 13000 events were detected on Mount Etna in August 2005 through a STA/LTA method. For this given period, the volcano does not present particular sign of unrest. The manifestation of the LP events is sustained in time over all the period of analysis. From the analysis of the directional properties, it turns out that the events of this first catalog propagate from 2 distinct sources . Furthermore, the events exhibit a high degree of waveform similarity, and provide a criterion for classification/source separation. The events were then grouped into families of comparable waveforms, resulting also in a separation for their source locations. We then used template signals of each family for a Matched-Filtering of the continuous data streams, in order to discriminate small-amplitude events previously undetected by the STA/LTA triggering method. This procedure allowed for a significant enrichment of the catalogues. The retrieved amplitude distributions

  2. Best-estimate analyses of LOFT anticipated transients with and without scram using DYNODE-P

    International Nuclear Information System (INIS)

    Kern, R.C.; Anderson, R.O.; Rautmann, D.A.

    1984-01-01

    Six LOFT transient tests with scram (L6-1, L6-2, L6-3, L6-7, L6-8B-1, and L6-8B-2) and two anticipated transient tests without scram (L9-3 and L9-4) have been analyzed using a best-estimate DYNODE-P/5.2 computer model. These tests span a wide range of anticipated operational occurrences for Pressurized Water Reactors. In general, satisfactory agreement between calculation and measurement for the key system parameters (nuclear power, primary and secondary pressures, temperatures, liquid levels, and flows) have been found. Sensitivity studies have resolved all significant discrepancies. These analyses have provided a significant qualification of the model for application to these types of events

  3. A review of analyses of LOFT and semiscale tests made at IDAHO National Engineering Laboratory using RELAP5/MOD1

    International Nuclear Information System (INIS)

    Hall, P.C.

    1984-03-01

    Within the LOFT and Semiscale programs at INEL, many post-test analysis calculations have been performed using RELAP5/MOD1. In this report, these calculations are reviewed from the standpoint of assessing the performance of the code. Because the calculations were spread over a number of years, different cycles of RELAP5/MOD1 have been employed. Rather than explicitly assessing several cycles of the code, a more general view has been adopted and an attempt has been made to identify those areas in which the code is systematically successful or alternatively, frequently experiences difficulties. (author)

  4. Learning from the experience: preliminary results of integration experiments within PRE-EARTHQUAKES EU-FP7 Project.

    Science.gov (United States)

    Tramutoli, V.; Inan, S.; Jakowski, N.; Pulinets, S.; Romanov, A.; Filizzola, C.; Shagimuratov, I.; Pergola, N.; Genzano, N.; Lisi, M.; Alparslan, E.; Wilken, V.; Tsybulia, K.; Romanov, A.; Paciello, R.; Balasco, M.; Zakharenkova, I.; Ouzounov, D.; Papadopoulos, G. A.; Parrot, M.

    2012-04-01

    PRE-EARTHQUAKES (Processing Russian and European EARTH observations for earthQUAKE precursors Studies) EU-FP7 project is devoted to demonstrate - integrating different observational data, comparing and improving different data analysis methods - how it is possible to progressively increase reliability of short term seismic risk assessment. Three main testing area were selected (Italy, Turkey and Sakhalin ) in order to concentrate observations and integration efforts starting with a learning phase on selected event in the past devoted to identify the most suitable parameters, observations technologies, data analysis algorithms. To this aim events offering major possibilities (variety) of integration were particularly considered - Abruzzo EQ (April 6th 2009 Mw 6.3) for Italy, Elazig EQ (March 8th 2010 Mw 6.1) for Turkey and Nevelsk EQ (August 2nd 2007 Mw 6.2) for Sakhalin - without excluding other significant events occurred during 2011 like the ones of Tōhoku in Japan and Van in Turkey. For these events, different ground (80 radon and 29 spring water stations in Turkey region, 2 magneto-telluric in Italy) and satellite (18 different systems) based observations, 11 data analysis methods, for 7 measured parameters, have been compared and integrated. Results achieved by applying a validation/confutation approach devoted to evaluate the presence/absence of anomalous space-time transients in single and/or integrated observation time-series will be discussed also in comparison with results independently achieved by other authors.

  5. 75 FR 38514 - Application to Export Electric Energy; Brookfield Energy Marketing LP

    Science.gov (United States)

    2010-07-02

    ... Energy Marketing LP AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Brookfield Energy Marketing LP (BEM LP) has applied for authority to transmit electric... surplus energy purchased from electric utilities, Federal power marketing agencies and other entities...

  6. Preparation of a dopamine transporter imaging agent 18F-FP-β-CIT and its biodistribution in rat brain

    International Nuclear Information System (INIS)

    Chen Zhengping; Wu Chunying; Li Xiaomin; Zhang Tongxing; Wang Songpei; Lu Chunxiong; Fu Ronggeng; Zhang Zhengwei; Guan Yihui

    2003-01-01

    Objective: To develop a simple and easy protocol of preparing 18 F-N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (FP-β-CIT) as a dopamine transporter imaging agent, and to study the distribution of this agent in rat brain. Methods: 18 F-FP-β-CIT was prepared by direct reaction in CH 3 CN between K 18 F and the labeling precursor, N-(3-(mesyloxy) propyl )-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (MsOP-CIT), in which Kryptofix 222 was used as phase transfer catalyst. 18 F-FP-β-CIT was purified through a Sep-Pak SiO 2 cartridge and eluted with ethyl ether. The purified 18 F-FP-β-CIT was injected into the rat's tail vein. These rats were sacrificed by cervical dislocation at different time points (5, 30, 60, 120, 180 min) after injection. The brain tissue of interest was removed, weighed, and radiocounted. Results: The radiochemical purity of 18 F-FP-β-CIT was over 95%, and the radiochemical yield from starting 18 F-fluoride was about 10%. 18 F-FP-β-CIT was absorbed rapidly in rat brain and was cleaned gradually (1.49, 0.59, 0.31, 0.21, 0.17%ID at 5, 30, 60, 120, 180 min, respectively). Radiouptake of striatum was more than that of other tissues and was cleaned slower than in other tissues at 60 min. Ratios of radiouptake of striatum /cerebellum were 1.75, 3.38, 3.73, 3.71 and 3.20 at 5, 30, 60, 120, 180 min, respectively. Conclusions: 18 F-FP-β-CIT is synthesized by a one-step protocol in which the preparative high performance liquid chromatography is not necessary in purifying procedure. The dominant distribution of 18 F-FP-β-CIT in rat striatum indicates that it is a potential dopamine transporter imaging agent

  7. Comparison of a lightweight polypropylene mesh (Optilene® LP) and a large-pore knitted PTFE mesh (GORE® INFINIT® mesh)--Biocompatibility in a standardized endoscopic extraperitoneal hernia model.

    Science.gov (United States)

    Jacob, Dietmar A; Schug-Pass, Christine; Sommerer, Florian; Tannapfel, Andrea; Lippert, Hans; Köckerling, Ferdinand

    2012-02-01

    The use of a mesh with good biocompatibility properties is of decisive importance for the avoidance of recurrences and chronic pain in endoscopic hernia repair surgery. As we know from numerous experiments and clinical experience, large-pore, lightweight polypropylene meshes possess the best biocompatibility. However, large-pore meshes of different polymers may be used as well and might be an alternative solution. Utilizing a totally extraperitoneal technique in an established animal model, 20 domestic pigs were implanted with either a lightweight large-pore polypropylene (PP) mesh (Optilene® LP) or a medium-weight large-pore knitted polytetrafluorethylene (PTFE) mesh (GORE® INFINIT® mesh). After 94 days, the pigs were sacrificed and postmortem diagnostic laparoscopy was performed, followed by explantation of the specimens for macroscopic, histological and immunohistochemical evaluation. The mean mesh shrinkage rate was 14.2% for Optilene® LP vs. 24.7% for INFINIT® mesh (p = 0.017). The partial volume of the inflammatory cells was 11.2% for Optilene® LP vs. 13.9% for INFINIT (n.s.). CD68 was significantly higher for INFINIT (11.8% vs. 5.6%, p = 0.007). The markers of cell turnover, namely Ki67 and the apoptotic index, were comparable at 6.4% vs. 12.4% (n.s.) and 1.6% vs. 2.0% (n.s.). In the extracellular matrix, TGF-β was 35.4% for Optilene® LP and 31.0% for INFINIT® (n.s.). Collagen I (pos/300 μm) deposits were 117.8 and 114.9, respectively. In our experimental examinations, Optilene® LP and INFINIT® showed a comparable biocompatibility in terms of chronic inflammatory reaction; however, the shrinkage rate was significantly higher for INFINIT® after 3 months. The higher shrinkage rate of INFINIT® should be taken into account when choosing the mesh size for an adequate hernia overlap.

  8. SPECT 123-I-[FP-CIT] diagnostic in the presynaptic parkinsonism

    International Nuclear Information System (INIS)

    Piperkova, E.; Georgiev, R.; Dimitrova, M.; Daskalov, M.; Orosova, M.; Milanova, M.; Danon, S.

    2005-01-01

    Detection of loss off functional dopaminergic neurone terminals in the striatum of patients with clinically uncertain Parkinsonian Syndromes will help to differentiate the Essential Tremor (ET) from the Parkinson Syndromes related to idiopathic Parkinson's Disease (PD), Multiple System Atrophy (MSA) or Progressive Supranuclear Palsy (PSP). In these cases dopaminic medication should be avoided for patients not suffering from true parkinsonism.Objective of the study is to determine the utility of [ 123 I] FP-CIT SPECT in clinically uncertain Parkinsonian syndromes and their differentiation from ET. Materials and Methods: This prospective study involved 9 patients (4 males and 5 females, aged between 38 - 81 years) with clinically uncertain Parkinsonism. The main symptoms were tremor (n=8), gait alteration (n=6), bradykinesia (n=3) and Negro phenomena positive (n=2), or a combination of these symptoms (n=9), with subsequent follow-up of 7-8 months. Dopamine agonists and antagonists acting on the postsynaptic dopamine receptors were not accepted to interfere with 123 I-Ioflupane. All patients underwent appropriate thyroid blocking by oral administration of 120 mg potassium iodide before and after [ 123 ] I FP-CIT application. All patents underwent SPECT scans 3-4 hours after i.v. injection of 185 MBq [ 123 ] FP-CIT (DaTSCAN - Amersham) on a Diacam Gamma-Camera System (Siemens). To estimate [ 123 ] FP-CIT biodistribution whole-body scans were performed, 15 minutes and 2-3 hrs after the i.v. application of the tracer. The SPECT results were evaluated visually and semi quantitatively. The [ 123 ] FP-CIT uptake of the striatum (nucleus caudatus and putamen) was referenced to the occipital cortex and to the symmetrical ROI. The scanning procedure was completed according to strict conditions for symmetry and geometry. The filtering and reconstructing procedures if the images were performed individually for each patient to avoid artifacts and errors. In all patients CT scans

  9. Dopamine transporter imaging with [123I]FP-CIT SPECT: potential effects of drugs

    International Nuclear Information System (INIS)

    Booij, Jan; Kemp, Paul

    2008-01-01

    [ 123 I]N-ω-fluoropropyl-2β-carbomethoxy-3β-{4-iodophenyl}nortropane ([ 123 I]FP-CIT) single photon emission computed tomography (SPECT) is a frequently and routinely used technique to detect or exclude dopaminergic degeneration by imaging the dopamine transporter (DAT) in parkinsonian and demented patients. This technique is also used in scientific studies in humans, as well as in preclinical studies to assess the availability of DAT binding in the striatum. In routine clinical studies, but also in scientific studies, patients are frequently on medication and sometimes even use drugs of abuse. Moreover, in preclinical studies, animals will be anesthetized. Prescribed drugs, drugs of abuse, and anesthetics may influence the visual interpretation and/or quantification of [ 123 I]FP-CIT SPECT scans. Here, we discuss the basic principle of how drugs and anesthetics might influence the visual interpretation and/or quantification of [ 123 I]FP-CIT SPECT scans. We also review drugs which are likely to have a significant influence on the visual interpretation and/or quantification of [ 123 I]FP-CIT SPECT scans. Additionally, we discuss the evidence as to whether frequently prescribed drugs in parkinsonian and demented patients may have an influence on the visual interpretation and/or quantification of [ 123 I]FP-CIT SPECT scans. Finally, we discuss our recommendations as to which drugs should be ideally withdrawn before performing a [ 123 I]FP-CIT SPECT scan for routine clinical purposes. The decision to withdraw any medication must always be made by the specialist in charge of the patient's care and taking into account the pros and cons of doing so. (orig.)

  10. Modulation of phosducin-like protein 3 (PhLP3 levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner.

    Directory of Open Access Journals (Sweden)

    Nandini V L Hayes

    Full Text Available Phosducin-like protein 3 (PhLP3 forms a ternary complex with the ATP-dependent molecular chaperone CCT and its folding client tubulin. In vitro studies suggest PhLP3 plays an inhibitory role in β-tubulin folding while conversely in vivo genetic studies suggest PhLP3 is required for the correct folding of β-tubulin. We have a particular interest in the cytoskeleton, its chaperones and their role in determining cellular phenotypes associated with high level recombinant protein expression from mammalian cell expression systems.As studies into PhLP3 function have been largely carried out in non mammalian systems, we examined the effect of human PhLP3 over-expression and siRNA silencing using a single murine siRNA on both tubulin and actin systems in mammalian Chinese hamster ovary (CHO cell lines. We show that over-expression of PhLP3 promotes an imbalance of α and β tubulin subunits, microtubule disassembly and cell death. In contrast, β-actin levels are not obviously perturbed. On-the-other-hand, RNA silencing of PhLP3 increases RhoA-dependent actin filament formation and focal adhesion formation and promotes a dramatic elongated fibroblast-like change in morphology. This was accompanied by an increase in phosphorylated MAPK which has been associated with promoting focal adhesion assembly and maturation. Transient overexpression of PhLP3 in knockdown experiments rescues cells from the morphological change observed during PhLP3 silencing but mitosis is perturbed, probably reflecting a tipping back of the balance of PhLP3 levels towards the overexpression state.Our results support the hypothesis that PhLP3 is important for the maintenance of β-tubulin levels in mammalian cells but also that its modulation can promote actin-based cytoskeletal remodelling by a mechanism linked with MAPK phosphorylation and RhoA-dependent changes. PhLP3 levels in mammalian cells are thus finely poised and represents a novel target for engineering industrially

  11. Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

    Science.gov (United States)

    Thomas, Alan J; Attems, Johannes; Colloby, Sean J; O'Brien, John T; McKeith, Ian; Walker, Rodney; Lee, Lean; Burn, David; Lett, Debra J; Walker, Zuzana

    2017-01-17

    To conduct a validation study of 123 I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane ( 123 I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. Patients >60 years of age with dementia who had undergone 123 I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria. All underwent 123 I-FP-CIT imaging at baseline, and scans were rated as normal or abnormal by blinded raters. Patients were reviewed in prospective studies and after death underwent detailed autopsy assessment, and neuropathologic diagnoses were applied with the use of standard international criteria. Fifty-five patients (33 with DLB and 22 with Alzheimer disease) were included. Against autopsy diagnosis, 123 I-FP-CIT had a balanced diagnostic accuracy of 86% (sensitivity 80%, specificity 92%) compared with clinical diagnosis, which had an accuracy of 79% (sensitivity 87%, specificity 72%). Among patients with DLB, 10% (3 patients) met pathologic criteria for Lewy body disease but had normal 123 I-FP-CIT imaging. This large autopsy analysis of 123 I-FP-CIT imaging in dementia demonstrates that it is a valid and accurate biomarker for DLB, and the high specificity compared with clinical diagnosis (20% higher) is clinically important. The results need to be replicated with patients recruited from a wider range of settings, including movement disorder clinics and general practice. While an abnormal 123 I-FP-CIT scan strongly supports Lewy body disease, a normal scan does not exclude DLB with minimal brainstem involvement. This study provides Class I evidence that 123 I-FP-CIT dopaminergic neuroimaging accurately identifies patients with DLB. Copyright © 2016 The Author(s). Published by Wolters Kluwer

  12. Online lektiehjælp

    DEFF Research Database (Denmark)

    Hansen, Jens Jørgen; Remvig, Kirstin

    2016-01-01

    vejledningsdidaktik, herunder metoder, modeller og materialer for lektievejledning i regi af Lektier Online. Lektier Online er en organisation ved Statsbiblioteket i Århus, der tilbyder en online lektiecafe, hvor bl.a. gymnasie-elever kan få hjælp af frivillige universitetsstuderende. Dette didaktiske de-sign er et...

  13. Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin.

    Science.gov (United States)

    Kato, Yukinari; Ogasawara, Satoshi; Oki, Hiroharu; Honma, Ryusuke; Takagi, Michiaki; Fujii, Yuki; Nakamura, Takuro; Saidoh, Noriko; Kanno, Hazuki; Umetsu, Mitsuo; Kamata, Satoshi; Kubo, Hiroshi; Yamada, Mitsuhiro; Sawa, Yoshihiko; Morita, Kei-Ichi; Harada, Hiroyuki; Suzuki, Hiroyoshi; Kaneko, Mika Kato

    2016-04-01

    Podoplanin (PDPN) is a type-I transmembrane sialoglycoprotein, which possesses a platelet aggregation-stimulating (PLAG) domain in its N-terminus. Among the three PLAG domains, O-glycan on Thr52 of PLAG3 is critical for the binding with C-type lectin-like receptor-2 (CLEC-2) and is essential for platelet-aggregating activity of PDPN. Although many anti-PDPN monoclonal antibodies (mAbs) have been established, almost all mAbs bind to PLAG domains. We recently established CasMab technology to produce mAbs against membranous proteins. Using CasMab technology, we produced a novel anti-PDPN mAb, LpMab-17, which binds to non-PLAG domains. LpMab-17 clearly detected endogenous PDPN of cancer cells and normal cells in Western-blot, flow cytometry, and immunohistochemistry. LpMab-17 recognized glycan-deficient PDPN in flow cytometry, indicating that the interaction between LpMab-17 and PDPN is independent of its glycosylation. The minimum epitope of LpMab-17 was identified as Gly77-Asp82 of PDPN using enzyme-linked immunosorbent assay. Of interest, LpMab-17 did not bind to monkey PDPN, whereas the homology is 94% between human PDPN and monkey PDPN, indicating that the epitope of LpMab-17 is unique compared with the other anti-PDPN mAbs. The combination of different epitope-possessing mAbs could be advantageous for the PDPN-targeting diagnosis or therapy.

  14. Embedded engineering education

    CERN Document Server

    Kaštelan, Ivan; Temerinac, Miodrag; Barak, Moshe; Sruk, Vlado

    2016-01-01

    This book focuses on the outcome of the European research project “FP7-ICT-2011-8 / 317882: Embedded Engineering Learning Platform” E2LP. Additionally, some experiences and researches outside this project have been included. This book provides information about the achieved results of the E2LP project as well as some broader views about the embedded engineering education. It captures project results and applications, methodologies, and evaluations. It leads to the history of computer architectures, brings a touch of the future in education tools and provides a valuable resource for anyone interested in embedded engineering education concepts, experiences and material. The book contents 12 original contributions and will open a broader discussion about the necessary knowledge and appropriate learning methods for the new profile of embedded engineers. As a result, the proposed Embedded Computer Engineering Learning Platform will help to educate a sufficient number of future engineers in Europe, capable of d...

  15. FP-LAPW study of the elastic properties of Al2X (X=Sc,Y,La,Lu)

    International Nuclear Information System (INIS)

    Rajagopalan, M.; Praveen Kumar, S.; Anuthama, R.

    2010-01-01

    From the first principles total energy calculations based on full-potential linear augmented plane wave method (FP-LAPW), the elastic properties of Al 2 X (X=Sc,Y,La,Lu) are reported here. Theoretical values of Young's modulus, shear modulus, Poisson's ratio and Debye temperature are estimated from the computed elastic constants. From the analysis of the ratio of shear to bulk modulus, it is found that these intermetallic compounds are brittle in nature. The calculated results are compared with other reported values.

  16. Stress analysis of LOFT containment vessel attachments for the mainsteam and feedwater piping support structures

    International Nuclear Information System (INIS)

    Finicle, D.P.

    1977-01-01

    The LOFT Containment Vessel attachments for the Mainsteam and Feedwater Piping Support Structures have been analyzed for operating and faulted loading conditions. This report contains the analysis of the connections to the containment vessel for the most current design and loading. Also contained in this report is the analysis of the piping supports

  17. LOFT reactor vessel 290/sup 0/ downcomer stalk instrument penetration flange stress analysis

    Energy Technology Data Exchange (ETDEWEB)

    Finicle, D.P.

    1978-06-06

    The LOFT Reactor Vessel 290/sup 0/ Downcomer Stalk Instrument Penetration Flange Stress Analysis has been completed using normal operational and blowdown loading. A linear elastic analysis was completed using simplified hand analysis techniques. The analysis was in accordance with the 1977 ASME Boiler and Pressure Vessel Code, Section III, for a Class 1 component. Loading included internal pressure, bolt preload, and thermal gradients due to normal operating and blowdown.

  18. Functional-light JavaScript balanced, pragmatic FP in JavaScript

    CERN Document Server

    Simpson, Kyle

    2017-01-01

    Functional-Light JavaScript is a balanced, pragmatic exploration of Functional Programming in JavaScript. Functional Programming (FP) is an incredibly powerful paradigm for structuring code that yields more robust, verifiable, and readable programs. If you've ever tried to learn FP but struggled with terms like "monad", mathematical concepts like category theory, or symbols like (lambda), you're not alone. Functional-Light programming distills the most vital aspects of FP—function purity, value immutability, composition, and more!—down to approachable JavaScript patterns. Rather than the all-or-nothing dogmatism often encountered in FP, this book teaches you how to improve your programs line by line.

  19. LOFT reflood as a function of accumulator initial gas volume

    International Nuclear Information System (INIS)

    Rhodes, H.F.

    1978-01-01

    The effect of the initial gas volume in the LOFT accumulators on the time to start of core reflood, after a LOCA, has been studied. The bases of the calculations are the data used and results presented in the Safety Analysis Report, Rev.1, August 1977, and the data in the RELAP and TOODEE2 program input and output listings. The results of this study show that an initial nitrogen volume of 12 cu ft, or more (at 600 psig initial pressure), would cause start of core reflood in time to prevent the cladding temperature from reaching 2200 0 F. The 12 cu ft initial volume will expand from 600 psig, initial pressure, to about 10 psig (containment pressure shortly after start of LOCA is approximately 8 psig) when all ECC liquid has been expelled from the accumulator. This pressure margin is considered too small; the ECC flowrate will be zero before the accumulator is empty

  20. Relative expression of bacterial and host specific genes associated with probiotic survival and viability in the mice gut fed with Lactobacillus plantarum Lp91.

    Science.gov (United States)

    Chandran, Archana; Duary, Raj Kumar; Grover, Sunita; Batish, Virender Kumar

    2013-11-07

    The present investigation was aimed at studying the relative expression of atpD (a key part of F1F0-ATPase operon), bsh (bile salt hydrolase), mub (mucus-binding protein) and MUC2 (mucin) genes in mouse model for establishing the in vivo functional efficacy of Lactobacillus plantarum Lp91 (MTCC5690) by reverse transcription-quantitative PCR (RT-qPCR). The atpD gene was significantly up-regulated to 2.0, 2.4 and 3.2 folds in Lp91 after 15, 30 and 60 min transit in the stomach of mice. The maximal significant (Pstrain Lp5276 after seven days of mice feeding. Simultaneously, mub gene expression increased to 12.8 and 22.7 fold in both Lp91 and Lp5276, respectively. The expression level of MUC2 was at the level of 1.6 and 2.1 fold in the host colon on administration with Lp91 and Lp5276 feeding, respectively. Hence, the expression of atpD, bsh, mub, MUC2 could be considered as prospective and potential biomarkers for screening of novel probiotic lactobacillus strains for optimal functionality in the gut. Copyright © 2013 Elsevier GmbH. All rights reserved.

  1. Utilisation des modules ATM pour le projet FP420

    CERN Document Server

    Renaglia, T

    2006-01-01

    Le but de cette note est de résumer les premières caractéristiques de l'intégration de 2 modules ATM pour le projet FP420 (voir note technique EDMS n° 743628) ainsi que la liste des problèmes découverts à ce jour sur l

  2. Acute administration of haloperidol does not influence 123I-FP-CIT binding to the dopamine transporter

    NARCIS (Netherlands)

    Booij, Jan; van Loon, Guus; de Bruin, Kora; Voorn, Pieter

    2014-01-01

    A recent (123)I-FP-CIT ((123)-I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane) SPECT study on rats suggested that a single 1 mg/kg dose of the antipsychotic haloperidol induces enough dopamine release to compete with (123)I-FP-CIT for binding to the dopamine transporter. Taking into

  3. LibraryH3lp: A New Flexible Chat Reference System

    Directory of Open Access Journals (Sweden)

    Pam Sessoms

    2008-09-01

    Full Text Available LibraryH3lp is an integrated IM and web chat system designed specifically for Virtual Reference services in libraries. The software was designed for, and is currently used by, a night-time chat reference collaboraton between several large academic libraries. LibraryH3lp is designed for the workflow of chat reference, supporting multiple simultaneous operators and routing to queues of operators in a particular service area. It also supports web page embeddable chat 'widgets', as well as simultaneous gateways to multiple IM protocols. This article discusses the motivation for the development of the software, and provides an overview of LibraryH3lp's features and technical architecture. Parts of LibraryH3lp are available as open source. The complete application is available as a low-cost hosted service, and will eventually be available to be licensed for local hosting.

  4. Effects of Menstrual Phase-Dependent Resistance Training Frequency on Muscular Hypertrophy and Strength.

    Science.gov (United States)

    Sakamaki-Sunaga, Mikako; Min, Seokki; Kamemoto, Kayoko; Okamoto, Takanobu

    2016-06-01

    The present study investigated how different training frequencies during menstrual phases affect muscle hypertrophy and strength. Fourteen eumenorrheic women performed 3 sets of arm curls (8-15 repetitions) until failure for 12 weeks. Depending on the menstrual cycle phase, each subject trained each arm separately after either a 3- or a 1-d·wk training protocol during the follicular phase (FP-T) and a 3- or 1-d·wk training protocol during the luteal phase (LP-T). Cross-sectional area (CSA), 1 repetition maximum, and maximum voluntary contraction significantly increased 6.2 ± 4.4, 36.4 ± 11.9, and 16.7 ± 5.6%, respectively (p ≤ 0.05 vs. before training), in the FP-T group and 7.8 ± 4.2, 31.8 ± 14.1, and 14.9 ± 12.7%, respectively (p ≤ 0.05 vs. before training), in the LP-T group. Changes in CSA between the FP-T and the LP-T groups significantly and positively correlated (r = 0.54, p ≤ 0.05). There were no major differences among the different training protocols with regard to muscle hypertrophy and strength. Therefore, we suggest that variations in female hormones induced by the menstrual cycle phases do not significantly contribute to muscle hypertrophy and strength gains during 12 weeks of resistance training.

  5. Computer Security: Well fought, FP!

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2015-01-01

    We are used to spam and phishing emails. But at the end of last year, a very special email struck one of our colleagues in the FP Department.   An accountant was gently asked in an email from “Rolf.Heuer@cern.ch” to prepare a financial transaction - in the strictest confidence. A phone call from the beneficiary to the accountant was made in an attempt to support this request. Despite being instructed not to talk to anyone, the e-mail, the phone conversation and the circumstances were all so suspicious that our colleague consulted his hierarchy, the internal audit service and us. Well done, FP Department! This is a rare case of an attempt at “social engineering”, i.e. luring someone into doing something detrimental to the Organization. The e-mail was fake. While it appeared to come from “Rolf.Heuer@cern.ch”, it actually came from an alleged fraudster outside CERN. The e-mail and the phone call showed that he was well prepared and dire...

  6. Thermal analysis of LOFT waste gas processing system nitrogen supply for process line purge and blower seal

    International Nuclear Information System (INIS)

    Tatar, G.A.

    1979-01-01

    The LOFT Waste Gas Processing System uses gaseous nitrogen (GN 2 ) to purge the main process line and to supply pressure on the blower labyrinth seal. The purpose of this analysis was to determine the temperature of the GN 2 at the blower seals and the main process line. Since these temperatures were below 32 0 F the heat rate necessary to raise these temperatures was calculated. This report shows that the GN 2 temperatures at the points mentioned above were below 10 0 F. A heat rate into the GN 2 of 389 Watts added at the point where the supply line enters the vault would raise the GN 2 temperature above 32 0 F

  7. The LP-ESP(®) lumbar disc prosthesis with 6 degrees of freedom: development and 7 years of clinical experience.

    Science.gov (United States)

    Lazennec, Jean-Yves; Aaron, Alain; Brusson, Adrien; Rakover, Jean-Patrick; Rousseau, Marc-Antoine

    2013-02-01

    The viscoelastic lumbar disk prosthesis-elastic spine pad (LP-ESP(®)) is an innovative one-piece deformable but cohesive interbody spacer providing 6 full degrees of freedom about the 3 axes, including shock absorption. A 20-year research program has demonstrated that this concept provides mechanical properties very close to those of a natural disk. Improvements in technology have made it possible to solve the problem of the bond between the elastic component and the titanium endplates and to obtain an excellent biostability. The prosthesis geometry allows limited rotation and translation with resistance to motion (elastic return property) aimed at avoiding overload of the posterior facets. The rotation center can vary freely during motion. It thus differs substantially from current prostheses, which are 2- or 3-piece devices involving 1 or 2 bearing surfaces and providing 3 or 5 degrees of freedom. This design and the adhesion-molding technology differentiate the LP-ESP prosthesis from other mono-elastomeric prostheses, for which the constraints of shearing during rotations or movement are absorbed at the endplate interface. Seven years after the first implantation, we can document in a solid and detailed fashion the course of clinical outcomes and the radiological postural and kinematic behavior of this prosthesis.

  8. 76 FR 49760 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2011-08-11

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-524-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on July 29, 2011, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056-5310, filed with the Federal Energy...

  9. 76 FR 7833 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2011-02-11

    ...] Texas Eastern Transmission, LP; Notice of Application Take notice that on January 25, 2011, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in the above... TEAM 2012 Project. Specifically, Texas Eastern requests: (i) Authorization under NGA sections 7(b) and...

  10. Dopamine transporter SPECT using fast kinetic ligands: 123I-FP-β-CIT versus 99mTc-TRODAT-1

    International Nuclear Information System (INIS)

    Laere, K. van; Ceuninck, L. de; Eynden, J. van den; Dupont, P.; Mortelmans, L.; Dom, R.; Vanbilloen, H.; Cleynhens, J.; Bormans, G.; Verbruggen, A.

    2004-01-01

    A comparative study was carried out on two promising presynaptic dopamine transporter single-photon emission tomography (SPECT) radioligands with a fast pharmacokinetic profile, 123 I-FP-β-CIT (FP) and 99m Tc-TRODAT-1 (TR), in order to assess their differential diagnostic power in early parkinsonism and their sensitivity for detection of disease progression. This cross-sectional study was conducted on 96 patients with early-stage parkinsonism referred in a tertiary clinical setting. Mean disease duration was 2.0±1.3 years, and patients had a modified Hoehn and Yahr (H and Y) stage of 1-2 (average 1.2). Forty-seven patients received TR, and 49 received FP. In both groups, ten patients with normal presynaptic function were included as a control population; all other patients were clinically diagnosed as having idiopathic Parkinson's disease. Groups were matched for gender, age, disease duration and modified H and Y stage. Triple-head gamma camera SPECT was analysed using a semiquantitative index of transporter binding (BI). Discriminant analysis with cross-validation resulted in a maximal classification accuracy for FP of 93% (sensitivity 95% and specificity 86%) for the contralateral putamen BI. For TR, the corresponding values were 87% accuracy, 92% sensitivity and 70% specificity. For FP, disease duration was correlated with both the putamen BI (-8.8%/year, ρ=-0.41, P=0.025) and the putamen/caudate ratio (-7.4%/year, ρ=-0.51, P=0.004), but for TR no significant correlation was found (all P values >0.5). In conclusion, both FP and TR show high sensitivity in a clinically relevant setting, but FP has superior accuracy for early differential diagnosis of idiopathic parkinsonism and non-degenerative extrapyramidal disorders, as well as better sensitivity for disease follow-up. (orig.)

  11. New low pressure (LP) turbines for NE Krsko

    International Nuclear Information System (INIS)

    Nemcic, K.; Novsak, M.

    2004-01-01

    During the evaluation of possible future maintenance strategies on steam turbine in very short period of time, engineering decision was made by NE Krsko in agreement with Owners to replace the existing two Low Pressure (LP) Turbines with new upgrading LP Turbines. This decision is presented with review of the various steam turbine problems as: SCC on turbine discs; blades cracking; erosion-corrosion with comparison of various maintenance options and efforts undertaken by the NE Krsko to improve performance of the original low pressure turbines. This paper presents the NEK approach to solve the possible future problems with steam turbine operation in NE Krsko as pro-active engineering and maintenance activities on the steam turbine. This paper also presents improvements involving retrofits, confined to the main steam turbine path, with major differences between original and new LP Turbines as beneficial replacement because of turbine MWe upgrading and return capital expenditures.(author)

  12. The role of LP gas in eradicating energy poverty

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, Michael; Behuria, Sarthak

    2010-09-15

    LP Gas is an ideal solution for dealing with energy poverty. Clean burning, low carbon, extremely efficient, requiring minimal infrastructure or R and D investment and with plentiful long term global supply, LP Gas can be quickly introduced to play an important role in eradicating energy poverty and steering both industrialised and developing countries onto more sustainable energy development paths.

  13. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a levels in African Americans.

    Directory of Open Access Journals (Sweden)

    Rahul C Deo

    2011-01-01

    Full Text Available Lipoprotein(a (Lp(a is an important causal cardiovascular risk factor, with serum Lp(a levels predicting atherosclerotic heart disease and genetic determinants of Lp(a levels showing association with myocardial infarction. Lp(a levels vary widely between populations, with African-derived populations having nearly 2-fold higher Lp(a levels than European Americans. We investigated the genetic basis of this difference in 4464 African Americans from the Jackson Heart Study (JHS using a panel of up to 1447 ancestry informative markers, allowing us to accurately estimate the African ancestry proportion of each individual at each position in the genome. In an unbiased genome-wide admixture scan for frequency-differentiated genetic determinants of Lp(a level, we found a convincing peak (LOD = 13.6 at 6q25.3, which spans the LPA locus. Dense fine-mapping of the LPA locus identified a number of strongly associated, common biallelic SNPs, a subset of which can account for up to 7% of the variation in Lp(a level, as well as >70% of the African-European population differences in Lp(a level. We replicated the association of the most strongly associated SNP, rs9457951 (p = 6 × 10(-22, 27% change in Lp(a per allele, ∼5% of Lp(a variance explained in JHS, in 1,726 African Americans from the Dallas Heart Study and found an even stronger association after adjustment for the kringle(IV repeat copy number. Despite the strong association with Lp(a levels, we find no association of any LPA SNP with incident coronary heart disease in 3,225 African Americans from the Atherosclerosis Risk in Communities Study.

  14. 76 FR 38381 - Texas Eastern Transmission, LP; Notice of Amendment

    Science.gov (United States)

    2011-06-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-67-001] Texas Eastern Transmission, LP; Notice of Amendment Take notice that on June 13, 2011, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in the above referenced docket an amendment...

  15. 77 FR 20015 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2012-04-03

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-88-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on March 19, 2012, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056-5310, filed an application in Docket No...

  16. 77 FR 12045 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2012-02-28

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-68-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on February 16, 2012, Texas Eastern Transmission, LP (Texas Eastern), PO Box 1642, Houston, Texas 77056 filed an application in the above referenced docket...

  17. Applicability of Phebus FP results to severe accident safety evaluations and management measures

    International Nuclear Information System (INIS)

    Schwarz, M.; Clement, B.; Jones, A.V.

    2001-01-01

    The international Phebus FP (Fission Product) programme is the largest research programme in the world investigating core degradation and radioactive product release should a core meltdown accident occur in a light water reactor plant. Three integral experiments have already been performed. The experimental database obtained so far contains a wealth of information to validate the computer codes used for safety and accident management assessment

  18. Design of combinatorial libraries for the exploration of virtual hits from fragment space searches with LoFT.

    Science.gov (United States)

    Lessel, Uta; Wellenzohn, Bernd; Fischer, J Robert; Rarey, Matthias

    2012-02-27

    A case study is presented illustrating the design of a focused CDK2 library. The scaffold of the library was detected by a feature trees search in a fragment space based on reactions from combinatorial chemistry. For the design the software LoFT (Library optimizer using Feature Trees) was used. The special feature called FTMatch was applied to restrict the parts of the queries where the reagents are permitted to match. This way a 3D scoring function could be simulated. Results were compared with alternative designs by GOLD docking and ROCS 3D alignments.

  19. Electronic structure and magnetic properties of Pr-Co intermetallics: ab initio FP-LAPW calculations and correlation with experiments

    Science.gov (United States)

    Bakkari, Karim; Fersi, Riadh; Kebir Hlil, El; Bessais, Lotfi; Thabet Mliki, Najeh

    2018-03-01

    First-principle calculations combining density functional theory and the full-potential linearized augmented plane wave (FP-LAPW) method are performed to investigate the electronic and magnetic structure of Pr2Co7 in its two polymorphic forms, (2:7 H) and (2:7 R), for the first time. This type of calculation was also performed for PrCo5 and PrCo2 intermetallics. We have computed the valence density of states separately for spin-up and spin-down states in order to investigate the electronic band structure. This is governed by the strong contribution of the partial DOS of 3d-Co bands compared to the partial DOS of the 4f-Pr bands. Such a high ferromagnetic state is discussed in terms of the strong spin polarization observed in the total DOS. The magnetic moments carried by the Co and Pr atoms located in several sites for all compounds are computed. These results mainly indicate that cobalt atoms make a dominant contribution to the magnetic moments. The notable difference in the atomic moments of Pr and Co atoms between different structural slabs is explained in terms of the magnetic characteristics of the PrCo2 and PrCo5 compounds and the local chemical environments of the Pr and Co atoms in different structural slabs of Pr2Co7. From spin-polarized calculations we have simulated the 3d and 4f band population to estimate the local magnetic moments. These results are in accordance with the magnetic moments calculated using the FP-LAPW method. In addition, the exchange interactions J ij are calculated and used as input for M(T) simulations. Involving the data obtained from the electronic structure calculations, the appropriate Padé Table is applied to simulate the magnetization M(T) and to estimate the mean-field Curie temperature. We report a fairly good agreement between the ab initio calculation of magnetization and Curie temperature with the experimental data.

  20. 78 FR 32294 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02...

    Science.gov (United States)

    2013-05-29

    ... Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of a... SMALL BUSINESS ADMINISTRATION DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02-0661; Notice Seeking Exemption Under Section 312 of the Small Business...

  1. Estimating the Population Impact of Lp(a) Lowering on the Incidence of Myocardial Infarction and Aortic Stenosis

    DEFF Research Database (Denmark)

    Afshar, Mehdi; Kamstrup, Pia R; Williams, Ken

    2016-01-01

    OBJECTIVE: High lipoprotein(a) (Lp[a]) is the most common genetic dyslipidemia and is a causal factor for myocardial infarction (MI) and aortic stenosis (AS). We sought to estimate the population impact of Lp(a) lowering that could be achieved in primary prevention using the therapies in developm......OBJECTIVE: High lipoprotein(a) (Lp[a]) is the most common genetic dyslipidemia and is a causal factor for myocardial infarction (MI) and aortic stenosis (AS). We sought to estimate the population impact of Lp(a) lowering that could be achieved in primary prevention using the therapies...... as measures of the population impact. For MI, the event rate was 4.0% versus 2.8% for high versus low Lp(a) (relative risk, 1.46; 95% confidence interval [CI], 1.45-1.46). The attributable risk was 1.26% (95% CI, 1.24-1.27), corresponding to 31.3% (95% CI, 31.0-31.7) of the excess MI risk in those with high...... and 7.8% for AS. CONCLUSIONS: Lp(a) lowering among the top 20% of the population distribution for Lp(a) could prevent 1 in 14 cases of MI and 1 in 7 cases of AS, suggesting a major impact on reducing the burden of cardiovascular disease. Targeting the top 10% could prevent 1 in 20 MI cases and 1 in 12...

  2. CERN in FP7: very successful participation so far

    CERN Multimedia

    2009-01-01

    The first two years of the seventh Framework Programme were very successful for CERN – 27 EU projects were selected for funding in 2007 and 2008, with the total EC contribution exceeding 33 million euros.The seventh European Union Framework Programme for research, technological development and demonstration activities (FP7) started on 1 January 2007 and will cover the period from 2007 to 2013. With a total budget of 50.5 billion euros, FP7 is the largest Framework Programme in the history of the EU. FP7 consists of four major sub-programmes, referred to as "Specific Programmes": "Cooperation" is focused on collaborative research projects and is divided into 10 thematic areas. "Ideas" is a new EU programme for funding frontier research in all fields of science. "Capacities" aims at strengthening the research capacities in Europe, including research infrastructures and e-infrastructures. Finally, "People" succeeds the p...

  3. Alpha particle cluster states in (fp)-shell nuclei

    International Nuclear Information System (INIS)

    Merchant, A.C.

    1987-07-01

    Alpha particle cluster structure is known experimentally to persist throughout the mass range 16 ≤ A ≤ 20, and has been very successfully described in this region in terms of the Buck-Dover-Vary local potential cluster model. It is argued that an analogous cluster structure should be present in nuclei at the beginning of the (fp) - shell, and the available experimental data are examined to determine likely alpha particle cluster state candidates in the mass range 40 ≤ A ≤ 44. Calculations of the cluster state spectra and mean square cluster-core separation distances (which may be readily used to evaluate E2 electromagnetic transition rates) for sup(40)Ca, sup(42)Ca, sup(42)Sc, sup(43)Sc, sup(43)Ti and sup(44)Ti using the above mentioned model are presented, and compared with experimental measurements where possible. The agreement between theory and experiment is generally good (although inferior to that obtained in the (sd)-shell) and points to the desirability of an extension and improvement of the measurements of the properties of the excited states in these nuclei. (author)

  4. 78 FR 66352 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2013-11-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-9-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on October 17, 2013, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed an application in Docket No. CP14-9...

  5. 78 FR 79687 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2013-12-31

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-29-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on December 10, 2013 Texas Eastern Transmission, LP (Texas Eastern), at 5400 Westheimer Court, Houston, Texas 77056, filed an application in Docket No. CP14...

  6. 77 FR 26534 - Texas Eastern Transmission, LP; Notice of Application

    Science.gov (United States)

    2012-05-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-164-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on April 19, 2012, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in Docket No. CP12-164-000, a request...

  7. FP-LAPW Calculations of the EFG at Cd Impurities in Rutile SnO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Errico, L. A.; Fabricius, G.; Renteria, M. [Universidad Nacional de La Plata, Instituto de Fisica La Plata (IFLP-CONICET) - Departamento de Fisica, Facultad de Ciencias Exactas (Argentina)

    2001-11-15

    We report an ab initio study of the electric-field gradient (EFG) at Cd impurities located at the cation site in the semiconductor SnO{sub 2}(rutile phase). The study was performed with the WIEN97 implementation of the FP-LAPW method. In order to simulate the diluted Cd-impurity in the SnO{sub 2} host and to calculate the electronic structure of the system we used a 72-atoms super-cell, studying the relaxation introduced by the impurity in the lattice. The free-relaxation process performed shows that the relaxations of the oxygen nearest-neighbors of the impurity are not isotropic. Our prediction for the EFG tensor are compared with experimental results and point-charge model predictions.

  8. Arctic Ice Dynamics Joint Experiment 1975-1976. Physical Oceanography Data Report, Salinity, Temperature and Depth Data, Camp Big Bear. Volume IV.

    Science.gov (United States)

    1980-02-01

    C to~~~ II qo 3 4 .. ..N~ V. ...... .V . .N N . .S ... .V .fI . i 0 Wi . .... . 53 .O .00... 0--N. .. ZZ W. I -. 0 -z J~~D &Z av F - -q qWe at s-a...q .a1 2c z oft ew dw- lp- eE- W - 0- fP- M .. 1 ,1e mc VftWU 00, 0%0 0000 - P-PtftoO. -%ffE Uqvv 4i . qwE ft . 04W -f ewF-0 wa rnm~~t.- tol Uw0 f E0

  9. Significance of Lipiodol-CT in the evaluation of therapeutic effects of Lp-TAE for hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Jinno, Kenji; Tokuyama, Katuyuki; Yumoto, Yasuhiro

    1988-01-01

    In 20 lesions of 17 patients treated with arterial infusion of SMANCS dissolved in lipiodol (Lp) and transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC), Lp deposition within the tumor were depicted on CT (Lp-CT). The findings of Lp-CT were compared with those of macroscopic, soft X-ray, and histologic examinations for resected specimens. Lp-CT appearance of HCC fell into four types: (I) complete type - round and homogeneous high density area (HDA) - in which Lp was deposited over the whole area; (II) defective type - inhomogeneous HDA - in which Lp was deposited in part of the tumor; (III) aggregated type - aggregation of small HDA; (IV) deficient type - no HDA - in which little or no Lp was deposited. Type I was found in 20 % of the lesions, type II in 25 %, type III in 20 %, and type IV in 35 %. In type I, HCC was of macroscopically nodular form with expansive growth and pseudocapsule and of histologically trabecular form with broad blood spaces and inviable cancer cells. In the other types, similar findings were seen in the necrotic area in which Lp was deposited, whereas scirrhous or compact type of HCC was histologically seen in the area containing viable cancer cells in which no Lp was deposited. The presence or not of Lp deposition, as depicted on CT, was closely correlated with histologic findings, which has significant implications for the evaluation of therapeutic efficacy of TAE with Lp. (Namekawa, K.)

  10. Dopamine transporter imaging with [{sup 123}I]FP-CIT SPECT: potential effects of drugs

    Energy Technology Data Exchange (ETDEWEB)

    Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Center, Amsterdam (Netherlands); Kemp, Paul [Southampton University Hospitals Trust, Department of Nuclear Medicine, Southampton (United Kingdom)

    2008-02-15

    [{sup 123}I]N-{omega}-fluoropropyl-2{beta}-carbomethoxy-3{beta}-{l_brace}4-iodophenyl{r_brace}nortropane ([{sup 123}I]FP-CIT) single photon emission computed tomography (SPECT) is a frequently and routinely used technique to detect or exclude dopaminergic degeneration by imaging the dopamine transporter (DAT) in parkinsonian and demented patients. This technique is also used in scientific studies in humans, as well as in preclinical studies to assess the availability of DAT binding in the striatum. In routine clinical studies, but also in scientific studies, patients are frequently on medication and sometimes even use drugs of abuse. Moreover, in preclinical studies, animals will be anesthetized. Prescribed drugs, drugs of abuse, and anesthetics may influence the visual interpretation and/or quantification of [{sup 123}I]FP-CIT SPECT scans. Here, we discuss the basic principle of how drugs and anesthetics might influence the visual interpretation and/or quantification of [{sup 123}I]FP-CIT SPECT scans. We also review drugs which are likely to have a significant influence on the visual interpretation and/or quantification of [{sup 123}I]FP-CIT SPECT scans. Additionally, we discuss the evidence as to whether frequently prescribed drugs in parkinsonian and demented patients may have an influence on the visual interpretation and/or quantification of [{sup 123}I]FP-CIT SPECT scans. Finally, we discuss our recommendations as to which drugs should be ideally withdrawn before performing a [{sup 123}I]FP-CIT SPECT scan for routine clinical purposes. The decision to withdraw any medication must always be made by the specialist in charge of the patient's care and taking into account the pros and cons of doing so. (orig.)

  11. Subcooled decompression analysis of the ROSA and the LOFT semiscale blowdown test data with the digital computer code DEPCO-MULTI

    International Nuclear Information System (INIS)

    Namatame, Ken; Kobayashi, Kensuke

    1975-12-01

    In the ROSA (Rig of Safety Assessment) program, the digital computer code DEPCO-SINGLE and DEPCO-MULTI (Subcooled Decompression Process in Loss-of-Coolant Accident - Single Pipe and - Multiple Pipe Network) were prepared to study thermo-hydraulic behavior of the primary coolant in subcooled decompression of the PWR LOCA. The analytical results with DEPCO-MULTI on the subcooled decompression phenomena are presented for ROSA-I, ROSA-II and LOFT 500, 600, 700 and 800 series experiments. The effects of space mesh length, elasticity of pressure boundary materials and simplification for computational piping system on the computed result are described. This will be the final work on the study of the subcooled decompression analysis as for the ROSA program, and the authors wish that the present code shall further be examined with the data of much advanced experiments. (auth.)

  12. Experiment data report for semiscale Mod-1 test S-01-1 (isothermal blowdown with core resistance simulator)

    International Nuclear Information System (INIS)

    Zender, S.N.; Crapo, H.S.; Jensen, M.F.; Sackett, K.E.

    1975-04-01

    Recorded test data are presented for Test S-01-1 of the semiscale Mod-1 isothermal blowdown test series. Test S-01-1 is one of several semiscale Mod-1 experiments which are counterparts of the planned Loss-of-Fluid Test (LOFT) nonnuclear experiments. System hardware is representative of the LOFT design, selected using volumetric scaling methods, and initial conditions duplicate those identified for the LOFT nonnuclear tests. Test S-01-1 was conducted from an initial temperature of 540 0 F and an initial pressure of 1596 psig. A simulated intermediate size double-ended hot leg break (0.00145 ft 2 break area on each end) was used to investigate the system response to a slow depressurization transient. An orificed structure was used in the pressure vessel to simulate the LOFT core simulator. During system depressurization, coolant was injected into the vessel downcomer inlet annulus to investigate the effectiveness of injection into the inlet annulus with respect to delivery of coolant to the lower plenum. Following the blowdown portion of Test S-01-1, coolant spray was introduced into the pressure suppression tank to determine the response of the pressure suppression system. The purpose of this report is to make available the uninterpreted data from Test S-01-1 for future data analysis and test results reporting activities. The data, presented in the form of graphs in engineering units, have been analyzed only to the extent necessary to assure that they are reasonable and consistent. (U.S.)

  13. Challenges in Implementing FP7 Projects in the Public Institutions

    Directory of Open Access Journals (Sweden)

    Viorel VULTURESCU

    2012-06-01

    Full Text Available National Authority for Scientific Research (ANCS and Executive Unit for Higher Education, Research and Development and Innovation Funding (UEFISCDI participate to several projects funded under the Framework Programmes, since 1998. The staff from each the two organisations participating in projects are merely the same, typically from “international cooperation” departments. In each of the two organisations, dedicated teams were set and a distinct specialization emerged. In this respect, dedicated procedures and good practices in project management were developed. Even the Framework Programs had different structures and the focused was different (e.g. knowledge creation, EU problem solving, scientific support for policies and programs, etc., the funding instruments (projects were not radically different from a Framework Program to another, so the staff could gain experience in managing this type of projects. Experience and expertise gained during this long period of time led to definition of a general framework within the two institutions and setting up of a general guideline for participation to this type of projects. The main dimensions of this framework are: project team organization, project management process, managing results and risk, organisational framework, good practices, factors which ensure success in project implementation.The paper presents a specific framework for FP 7 project implementation and how this framework is applied by both organisations, a set of rules and procedures that should be followed by any organisation, in particular governmental ones, participating in FP 7 projects and a set of good practices developed by ANCS and UEFISCDI.

  14. Long Period (LP) volcanic earthquake source location at Merapi volcano by using dense array technics

    Science.gov (United States)

    Metaxian, Jean Philippe; Budi Santoso, Agus; Laurin, Antoine; Subandriyo, Subandriyo; Widyoyudo, Wiku; Arshab, Ghofar

    2015-04-01

    Since 2010, Merapi shows unusual activity compared to last decades. Powerful phreatic explosions are observed; some of them are preceded by LP signals. In the literature, LP seismicity is thought to be originated within the fluid, and therefore to be representative of the pressurization state of the volcano plumbing system. Another model suggests that LP events are caused by slow, quasi-brittle, low stress-drop failure driven by transient upper-edifice deformations. Knowledge of the spatial distribution of LP events is fundamental for better understanding the physical processes occurring in the conduit, as well as for the monitoring and the improvement of eruption forecasting. LP events recorded at Merapi have a spectral content dominated by frequencies between 0.8 and 3 Hz. To locate the source of these events, we installed a seismic antenna composed of 4 broadband CMG-6TD Güralp stations. This network has an aperture of 300 m. It is located on the site of Pasarbubar, between 500 and 800 m from the crater rim. Two multi-parameter stations (seismic, tiltmeter, S-P) located in the same area, equipped with broadband CMG-40T Güralp sensors may also be used to complete the data of the antenna. The source of LP events is located by using different approaches. In the first one, we used a method based on the measurement of the time delays between the early beginnings of LP events for each array receiver. The observed differences of time delays obtained for each pair of receivers are compared to theoretical values calculated from the travel times computed between grid nodes, which are positioned in the structure, and each receiver. In a second approach, we estimate the slowness vector by using MUSIC algorithm applied to 3-components data. From the slowness vector, we deduce the back-azimuth and the incident angle, which give an estimation of LP source depth in the conduit. This work is part of the Domerapi project funded by French Agence Nationale de la Recherche (https

  15. 78 FR 11567 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2013-02-19

    ... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39...

  16. 76 FR 70040 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2011-11-10

    ... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (type certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and... new AD: 2011-23-07 Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft...

  17. Effects of LP-MOCVD prepared TiO2 thin films on the in vitro behavior of gingival fibroblasts

    International Nuclear Information System (INIS)

    Cimpean, Anisoara; Popescu, Simona; Ciofrangeanu, Cristina M.; Gleizes, Alain N.

    2011-01-01

    We report on the in vitro response of human gingival fibroblasts (HGF-1 cell line) to various thin films of titanium dioxide (TiO 2 ) deposited on titanium (Ti) substrates by low pressure metal-organic chemical vapor deposition (LP-MOCVD). The aim was to study the influence of film structural parameters on the cell behavior comparatively with a native-oxide covered titanium specimen, this objective being topical and interesting for materials applications in implantology. HGF-1 cells were cultured on three LP-MOCVD prepared thin films of TiO 2 differentiated by their thickness, roughness, transversal morphology, allotropic composition and wettability, and on a native-oxide covered Ti substrate. Besides traditional tests of cell viability and morphology, the biocompatibility of these materials was evaluated by fibronectin immunostaining, assessment of cell proliferation status and the zymographic evaluation of gelatinolytic activities specific to matrix metalloproteinases secreted by cells grown in contact with studied specimens. The analyzed surfaces proved to influence fibronectin fibril assembly, cell proliferation and capacity to degrade extracellular matrix without considerably affecting cell viability and morphology. The MOCVD of TiO 2 proved effective in positively modifying titanium surface for medical applications. Surface properties playing a crucial role for cell behavior were the wettability and, secondarily, the roughness, HGF-1 cells preferring a moderately rough and wettable TiO 2 coating.

  18. LOFT ECC Pitot Tube and Thermocouple Rake Penetration thermal analysis

    International Nuclear Information System (INIS)

    Tolan, B.J.

    1977-01-01

    A thermal analysis of the LOFT ECC Pitot Tube and Thermocouple Rake Penetration was performed using COUPLE, a two-dimensional finite element computer code. Four transients which conservatively cover all transients the rake will be exposed to were included in this analysis in order to comply with the ASME Code Section III requirements. The transients conservatively cover hot and cold leg operation, and nuclear and nonnuclear operation. The four transients include the LOCE with ECC injection transient, the single control rod drop transient, the scram transient, and the heatup with 0 to 100% load change transient. Temperature distributions in the rake were obtained for each of the four transients and several plots of node temperatures vs. time are given

  19. Training Lp norm multiple kernel learning in the primal.

    Science.gov (United States)

    Liang, Zhizheng; Xia, Shixiong; Zhou, Yong; Zhang, Lei

    2013-10-01

    Some multiple kernel learning (MKL) models are usually solved by utilizing the alternating optimization method where one alternately solves SVMs in the dual and updates kernel weights. Since the dual and primal optimization can achieve the same aim, it is valuable in exploring how to perform Lp norm MKL in the primal. In this paper, we propose an Lp norm multiple kernel learning algorithm in the primal where we resort to the alternating optimization method: one cycle for solving SVMs in the primal by using the preconditioned conjugate gradient method and other cycle for learning the kernel weights. It is interesting to note that the kernel weights in our method can obtain analytical solutions. Most importantly, the proposed method is well suited for the manifold regularization framework in the primal since solving LapSVMs in the primal is much more effective than solving LapSVMs in the dual. In addition, we also carry out theoretical analysis for multiple kernel learning in the primal in terms of the empirical Rademacher complexity. It is found that optimizing the empirical Rademacher complexity may obtain a type of kernel weights. The experiments on some datasets are carried out to demonstrate the feasibility and effectiveness of the proposed method. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. PanFP: pangenome-based functional profiles for microbial communities.

    Science.gov (United States)

    Jun, Se-Ran; Robeson, Michael S; Hauser, Loren J; Schadt, Christopher W; Gorin, Andrey A

    2015-09-26

    For decades there has been increasing interest in understanding the relationships between microbial communities and ecosystem functions. Current DNA sequencing technologies allows for the exploration of microbial communities in two principle ways: targeted rRNA gene surveys and shotgun metagenomics. For large study designs, it is often still prohibitively expensive to sequence metagenomes at both the breadth and depth necessary to statistically capture the true functional diversity of a community. Although rRNA gene surveys provide no direct evidence of function, they do provide a reasonable estimation of microbial diversity, while being a very cost-effective way to screen samples of interest for later shotgun metagenomic analyses. However, there is a great deal of 16S rRNA gene survey data currently available from diverse environments, and thus a need for tools to infer functional composition of environmental samples based on 16S rRNA gene survey data. We present a computational method called pangenome-based functional profiles (PanFP), which infers functional profiles of microbial communities from 16S rRNA gene survey data for Bacteria and Archaea. PanFP is based on pangenome reconstruction of a 16S rRNA gene operational taxonomic unit (OTU) from known genes and genomes pooled from the OTU's taxonomic lineage. From this lineage, we derive an OTU functional profile by weighting a pangenome's functional profile with the OTUs abundance observed in a given sample. We validated our method by comparing PanFP to the functional profiles obtained from the direct shotgun metagenomic measurement of 65 diverse communities via Spearman correlation coefficients. These correlations improved with increasing sequencing depth, within the range of 0.8-0.9 for the most deeply sequenced Human Microbiome Project mock community samples. PanFP is very similar in performance to another recently released tool, PICRUSt, for almost all of survey data analysed here. But, our method is unique

  1. Recalculation of loads on LOFT penetrations 1A, 2A, 3E, 3F, 5A, 5B, 5C, 5D, 5E, 5F, 7A, 9A, 11C, 17A, 17B, 20A, 20B, 20C, 21A

    International Nuclear Information System (INIS)

    McFadden, D.F.

    1978-01-01

    The loads on the piping nozzles penetrating the LOFT containment vessel are presented. Since the design and construction of the containment vessel, piping systems that penetrate the nozzles have been changed. Consequently, the moments and forces on the containment vessel are different than those stated in LOFT specification S-1. Two combined load cases were tabulated, deadweight plus thermal expansion plus operating basis earthquake and deadweight plus safe shutdown earthquake

  2. Antiglycopeptide Mouse Monoclonal Antibody LpMab-21 Exerts Antitumor Activity Against Human Podoplanin Through Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity.

    Science.gov (United States)

    Kato, Yukinari; Kunita, Akiko; Fukayama, Masashi; Abe, Shinji; Nishioka, Yasuhiko; Uchida, Hiroaki; Tahara, Hideaki; Yamada, Shinji; Yanaka, Miyuki; Nakamura, Takuro; Saidoh, Noriko; Yoshida, Kanae; Fujii, Yuki; Honma, Ryusuke; Takagi, Michiaki; Ogasawara, Satoshi; Murata, Takeshi; Kaneko, Mika K

    2017-02-01

    The interaction between podoplanin (PDPN) and C-type lectin-like receptor 2 (CLEC-2) is involved in tumor malignancy. We have established many monoclonal antibodies (mAbs) against human podoplanin using the cancer-specific mAb (CasMab) technology. LpMab-21, one of the mouse antipodoplanin mAbs, is of the IgG 2a subclass, and its minimum epitope was determined to be Thr76-Arg79 of the human podoplanin. Importantly, sialic acid is linked to Thr76; therefore, LpMab-21 is an antiglycopeptide mAb (GpMab). In this study, we investigated whether LpMab-21 shows antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against human podoplanin-expressing cancer cell lines in vitro and also studied its antitumor activities using a xenograft model. LpMab-21 showed high ADCC and CDC activities against not only podoplanin-expressing Chinese hamster ovary cells but also LN319 glioblastoma cells and PC-10 lung cancer cells, both of which endogenously express podoplanin. Furthermore, LpMab-21 decreased tumor growth in vivo, indicating that LpMab-21 could be useful for antibody therapy against human podoplanin-expressing cancers.

  3. On $L_p$ Affine Surface Area and Curvature Measures

    OpenAIRE

    Zhao, Yiming

    2015-01-01

    The relationship between $L_p$ affine surface area and curvature measures is investigated. As a result, a new representation of the existing notion of $L_p$ affine surface area depending only on curvature measures is derived. Direct proofs of the equivalence between this new representation and those previously known are provided. The proofs show that the new representation is, in a sense, "polar" to that of Lutwak's and "dual" to that of Sch\\"utt & Werner's.

  4. Global scaling for semi-quantitative analysis in FP-CIT SPECT.

    Science.gov (United States)

    Kupitz, D; Apostolova, I; Lange, C; Ulrich, G; Amthauer, H; Brenner, W; Buchert, R

    2014-01-01

    Semi-quantitative characterization of dopamine transporter availability from single photon emission computed tomography (SPECT) with 123I-ioflupane (FP-CIT) is based on uptake ratios relative to a reference region. The aim of this study was to evaluate the whole brain as reference region for semi-quantitative analysis of FP-CIT SPECT. The rationale was that this might reduce statistical noise associated with the estimation of non-displaceable FP-CIT uptake. 150 FP-CIT SPECTs were categorized as neurodegenerative or non-neurodegenerative by an expert. Semi-quantitative analysis of specific binding ratios (SBR) was performed with a custom-made tool based on the Statistical Parametric Mapping software package using predefined regions of interest (ROIs) in the anatomical space of the Montreal Neurological Institute. The following reference regions were compared: predefined ROIs for frontal and occipital lobe and whole brain (without striata, thalamus and brainstem). Tracer uptake in the reference region was characterized by the mean, median or 75th percentile of its voxel intensities. The area (AUC) under the receiver operating characteristic curve was used as performance measure. The highest AUC of 0.973 was achieved by the SBR of the putamen with the 75th percentile in the whole brain as reference. The lowest AUC for the putamen SBR of 0.937 was obtained with the mean in the frontal lobe as reference. We recommend the 75th percentile in the whole brain as reference for semi-quantitative analysis in FP-CIT SPECT. This combination provided the best agreement of the semi-quantitative analysis with visual evaluation of the SPECT images by an expert and, therefore, is appropriate to support less experienced physicians.

  5. A New Algorithm for Detecting Cloud Height using OMPS/LP Measurements

    Science.gov (United States)

    Chen, Zhong; DeLand, Matthew; Bhartia, Pawan K.

    2016-01-01

    The Ozone Mapping and Profiler Suite Limb Profiler (OMPS/LP) ozone product requires the determination of cloud height for each event to establish the lower boundary of the profile for the retrieval algorithm. We have created a revised cloud detection algorithm for LP measurements that uses the spectral dependence of the vertical gradient in radiance between two wavelengths in the visible and near-IR spectral regions. This approach provides better discrimination between clouds and aerosols than results obtained using a single wavelength. Observed LP cloud height values show good agreement with coincident Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) measurements.

  6. Experiment data report for semiscale Mod-1 Tests S-01-4 and S-01-4A (isothermal blowdown with core resistance simulator)

    International Nuclear Information System (INIS)

    Zender, S.N.; Jensen, M.F.; Sackett, K.E.

    1975-03-01

    Recorded test data are presented for Tests S-01-4 and S-01-4A of the semiscale Mod-1 isothermal blowdown test series. These tests are among several semiscale Mod-1 experiments which are counterparts of the planned Loss-of-Fluid Test (LOFT) nonnuclear experiments. System hardware is representative of LOFT design based on volumetric scaling methods, and initial conditions duplicate those identified for the LOFT nonnuclear tests. Tests S-01-4 and S-01-4A employed an intact loop resistance that was similar to that of Test S-01-3 and low relative to that of Test S-01-2. An orificed structure was used in the pressure vessel to simulate the LOFT core simulator. The tests were initiated at initial isothermal conditions of about 2250 psig and 540 0 F by a simulated offset shear of the cold-leg broken-loop piping. During system depressurization, coolant was injected into the cold leg of the intact loop to provide data on the effects of emergency core cooling on system response. Following the blowdown portion of Test S-01-4, coolant spray was introduced into the pressure suppression tank to determine the response of the pressure suppression system. The uninterpreted data are presented. The data, presented in the form of graphs in engineering units, have been analyzed only to the extent necessary to assure that they are reasonable and consistent. (U.S.)

  7. JNDC FP decay data file

    International Nuclear Information System (INIS)

    Yamamoto, Tohru; Akiyama, Masatsugu

    1981-02-01

    The decay data file for fission product nuclides (FP DECAY DATA FILE) has been prepared for summation calculation of the decay heat of fission products. The average energies released in β- and γ-transitions have been calculated with computer code PROFP. The calculated results and necessary information have been arranged in tabular form together with the estimated results for 470 nuclides of which decay data are not available experimentally. (author)

  8. Class I review of LOFT steam generator stress and fatigue life analysis report

    International Nuclear Information System (INIS)

    Fors, R.M.; Silverman, S.

    1977-01-01

    Review of the LOFT steam generator stress and fatigue life analysis report is presented. Deficiencies were found which will require evaluation and in some areas reanalysis. The effects of these deficiencies upon the steam generator will include: to further reduce the allowable ΔP across the tubesheet for the abnormal design case of pressure on primary; and to reduce the allowable number of LOCE transients at some locations of the steam generator from the numbers listed in the stress report and to increase them at other locations

  9. Current applications of optimal estimation and control theory to the LOFT reactor plant

    International Nuclear Information System (INIS)

    Feeley, J.J.; Tylee, J.L.

    1980-01-01

    Two advanced estimation and control systems being developed for the LOFT reactor plant are described and evaluated. The advanced protection system, based on a Kalman filter estimator is capable of providing on-line estimates of such critical variables as fuel and cladding temperature, DNBR, and LHGR. The steam generator LQG control system provides stable, closed-loop, zero steady state error control over a wide power range and also provides on-line estimates of certain unmeasureable variables as steam generator power output and cooling capacity for operator information

  10. The effects of menstrual cycle phase on physical performance in female soccer players

    Science.gov (United States)

    Julian, Ross; Hecksteden, Anne; Fullagar, Hugh H. K.; Meyer, Tim

    2017-01-01

    Background Female soccer has grown extensively in recent years, however differences in gender-specific physiology have rarely been considered. The female reproductive hormones which rise and fall throughout the menstrual cycle, are known to affect numerous cardiovascular, respiratory, thermoregulatory and metabolic parameters, which in turn, may have implications on exercise physiology and soccer performance. Therefore, the main aim of the present study was to investigate potential effects of menstrual cycle phase on performance in soccer specific tests. Methods Nine sub elite female soccer players, all of whom have menstrual cycles of physiological length; performed a series of physical performance tests (Yo-Yo Intermittent endurance test (Yo-Yo IET), counter movement jump (CMJ) and 3x30 m sprints). These were conducted at distinct time points during two main phases of the menstrual cycle (early follicular phase (FP) and mid luteal phase (LP)) where hormones contrasted at their greatest magnitude. Results Yo-Yo IET performance was considerably lower during the mid LP (2833±896 m) as compared to the early FP (3288±800 m). A trend towards significance was observed (p = 0.07) and the magnitude based inferences suggested probabilities of 0/61/39 for superiority/equality/inferiority of performance during the mid LP, leading to the inference of a possibly harmful effect. For CMJ (early FP, 20.0±3.9 cm; mid LP 29.6±3.0 cm, p = 0.33) and sprint (early FP, 4.7±0.1 s; mid LP, 4.7±0.1 s, p = 0.96) performances the results were unclear (8/24/68, 48/0/52, respectively). Conclusion The results of this study are in support of a reduction in maximal endurance performance during the mid LP of the menstrual cycle. However, the same effect was not observed for jumping and sprint performance. Therefore, consideration of cycle phase when monitoring a player’s endurance capacity may be worthwhile. PMID:28288203

  11. 78 FR 69078 - Houston Pipe Line Company LP; Notice of Application

    Science.gov (United States)

    2013-11-18

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-13-000] Houston Pipe Line Company LP; Notice of Application Take notice that on October 28, 2013, Houston Pipe Line Company LP (HPL), 1300 Main Street, Houston, Texas 77002, filed an application in Docket No. CP14-13-000...

  12. An attempt for revision of JNDC FP decay data file

    International Nuclear Information System (INIS)

    Katakura, Jun-ichi; Matsumoto, Zyun-itiro; Akiyama, Masatsugu; Yoshida, Tadashi; Nakasima, Ryozo.

    1984-06-01

    Some improvement of JNDC FP Decay Data File is tried by reexamining the decay scheme for several nuclides, since slight discrepancies are seen in detailed comparison of decay powers. As a results, it is found that the average beta- and gamma-energies should be modified for 88 Rb and 143 La among the nuclides reexamined in the present study. The JNDC file modified in 88 Rb and 143 La gives better agreement in most cases with experiments than the original JNDC file for cooling times longer than a few thousands seconds. However, the discrepancy for cooling times from a few hundreds to about 1500 seconds still remains. (author)

  13. IS30-related transposon mediated insertional inactivation of bile salt hydrolase (bsh1) gene of Lactobacillus plantarum strain Lp20.

    Science.gov (United States)

    Kumar, Rajesh; Grover, Sunita; Kaushik, Jai K; Batish, Virender Kumar

    2014-01-01

    Lactobacillus plantarum is a flexible and versatile microorganism that inhabits a variety of niches, and its genome may express up to four bsh genes to maximize its survival in the mammalian gut. However, the ecological significance of multiple bsh genes in L. plantarum is still not clearly understood. Hence, this study demonstrated the disruption of bile salt hydrolase (bsh1) gene due to the insertion of a transposable element in L. plantarum Lp20 - a wild strain of human fecal origin. Surprisingly, L. plantarum strain Lp20 produced a ∼2.0 kb bsh1 amplicon against the normal size (∼1.0 kb) bsh1 amplicon of Bsh(+)L. plantarum Lp21. Strain Lp20 exhibited minimal Bsh activity in spite of having intact bsh2, bsh3 and bsh4 genes in its genome and hence had a Bsh(-) phenotype. Cloning and sequence characterization of Lp20 bsh1 gene predicted four individual open reading frames (ORFs) within this region. BLAST analysis of ORF1 and ORF2 revealed significant sequence similarity to the L. plantarum bsh1 gene while ORF3 and ORF4 showed high sequence homology to IS30-family transposases. Since, IS30-related transposon element was inserted within Lp20 bsh1 gene in reverse orientation (3'-5'), it introduced several stop codons and disrupted the protein reading frames of both Bsh1 and transposase. Inverted terminal repeats (GGCAGATTG) of transposon, mediated its insertion at 255-263 nt and 1301-1309 nt positions of Lp20 bsh1 gene. In conclusion, insertion of IS30 related-transposon within the bsh1 gene sequence of L. plantarum strain Lp20 demolished the integrity and functionality of Bsh1 enzyme. Additionally, this transposon DNA sequence remains active among various Lactobacillus spp. and hence harbors the potential to be explored in the development of efficient insertion mutagenesis system. Copyright © 2013 Elsevier GmbH. All rights reserved.

  14. [123I]FP-CIT binding in rat brain after acute and sub-chronic administration of dopaminergic medication

    International Nuclear Information System (INIS)

    Lavalaye, J.; Knol, R.J.J.; Bruin, K. de; Reneman, L.; Booij, J.; Janssen, A.G.M.

    2000-01-01

    The recently developed radioligand [ 123 I]FP-CIT is suitable for clinical single-photon emission tomography (SPET) imaging of the dopamine (DA) transporter in vivo. To date it has remained unclear whether dopaminergic medication influences the striatal [ 123 I]FP-CIT binding. The purpose of this study was to investigate the influence of this medication on [ 123 I]FP-CIT binding in the brain. We used an animal model in which we administered dopaminomimetics, antipsychotics and an antidepressant. In vivo [ 123 I]FP-CIT binding to the DA and serotonin transporters was evaluated after sub-chronic and acute administration of the drugs. The administered medication induced small changes in striatal [ 123 I]FP-CIT binding which were not statistically significant. As expected, the DA reuptake blocker GBR 12,909 induced a significant decrease in [ 123 I]FP-CIT binding. [ 123 I]FP-CIT binding in the serotonin-rich hypothalamus was decreased only after acute administration of fluvoxamine. The results of this study suggest that dopaminergic medication will not affect the results of DA transporter SPET imaging with [ 123 I]FP-CIT. (orig.)

  15. Practical benefit of [123I[FP-CIT SPET in the demonstration of the dopaminergic deficit in Parkinson's disease

    International Nuclear Information System (INIS)

    Booij, J.; Tissingh, G.; Winogrodzka, A.; Boer, G.J.; Wolters, E.C.; Royen, E.A. van

    1997-01-01

    Loss of striatal dopamine (DA) transporters in Parkinson's disease (PD) has been accurately assessed in vivo by single-photon emission tomography (SPET) studies using [ 123 I[β-CIT. However, these studies have also shown that adequate imaging of the striatal DA transporter content can be performed only 20-30 h following the injection of [ 123 I[β-CIT, which is not convenient for routine out-patient evaluations. Recently, a new ligand, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)tropane (FP-CIT), became available for in vivo imaging of the DA transporter. The faster kinetics of [ 123 I[FP-CIT have been shown to allow adequate acquisition as early as 3 h following injection. In the present study, loss of striatal DA transporters in five non-medicated PD patients was assessed on two consecutive SPET scans, one with [ 123 I[β-CIT (24 h following injection) and one with [ 123 I[FP-CIT (3 h following injection). The ratios of specific to non-specific [ 123 I[FP-CIT uptake in the caudate nucleus and putamen were consistently 2.5-fold lower than those of [ 123 I[β-CIT. However, when the uptake ratio of both ligands in these brain regions of patients was expressed as a percentage of the uptake ratio found in healthy controls, both the decrease and the variation of the data were similar. It is concluded on the basis of these findings that [ 123 I[FP-CIT seems as good as [ 123 I[β-CIT for the assessment of the dopaminergic deficit in PD. The faster kinetics of [ 123 I[FP-CIT are a clear advantage. (orig.). With 3 figs

  16. Synthesis and labelling of 125/131I-FP-β-CIT as a dopamine transporter imaging agent

    International Nuclear Information System (INIS)

    Fang Ping; Chen Zhengping; Zhou Xiang

    2002-01-01

    The ligand of N-(3-fluoro propyl)-2β-carbomethoxy-3β-(4'-iodo phenyl) nortropane (FP-β-CIT) and its tributylstannyl precursor were synthesized by hydrolysis of cocaine, and then dehydration, esterification, Grignard reaction, n-demethylation, iodination, n-alkylation and tributylstannylation. 125/131 I-FP-β-CIT were prepared by oxidation radioiododestannylation, using peroxy acetic acid as oxidant, of its tributylstannyl precursor. The stable labelled compound was synthesized with high radiochemical purity at pH 4-7

  17. Growth of electron plasma waves above and below f(p) in the electron foreshock

    Science.gov (United States)

    Cairns, Iver H.; Fung, Shing F.

    1988-01-01

    This paper investigates the conditions required for electron beams to drive wave growth significantly above and below the electron plasma frequency, f(p), by numerically solving the linear dispersion equation. It is shown that kinetic growth well below f(p) may occur over a broad range of frequencies due to the beam instability, when the electron beam is slow, dilute, and relatively cold. Alternatively, a cold or sharp feature at low parallel velocities in the distribution function may drive kinetic growth significantly below f(p). Kinetic broadband growth significantly above f(p) is explained in terms of faster warmer beams. A unified qualitative theory for the narrow-band and broad-band waves is proposed.

  18. Current applications of optimal estimation and control theory to the LOFT reactor plant

    International Nuclear Information System (INIS)

    Feeley, J.J.; Tylee, J.L.

    1980-01-01

    Two advanced estimation and control systems being developed for the LOFT reactor plant are described and evaluated. The advanced protection system, based on a Kalman filter estimator is capable of providing on-line estimates of such critical variables as fuel and cladding temperature, DNBR, and LHGR. The steam generator LQG control system provides stable, closed-loop, zero steady state error control over a wide power range and also provides on-line estimates of certain unmeasureable variables as steam generator power output and cooling capacity for operator information. 12 refs

  19. [(123)I]FP-CIT ENC-DAT normal database

    DEFF Research Database (Denmark)

    Tossici-Bolt, Livia; Dickson, John C; Sera, Terez

    2017-01-01

    BACKGROUND: [(123)I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-specific reference values for the [(123)I]FP-CIT specific binding ratio...... quantifications methods, BRASS and Southampton, and explores the performance of the striatal phantom calibration in their harmonisation. RESULTS: BRASS and Southampton databases comprising 123 ENC-DAT subjects, from gamma cameras with parallel collimators, were reconstructed using filtered back projection (FBP......) and iterative reconstruction OSEM without corrections (IRNC) and compared against the recommended OSEM with corrections for attenuation and scatter and septal penetration (ACSC), before and after applying phantom calibration. Differences between databases were quantified using the percentage difference...

  20. Meningococcal Serogroup B Bivalent rLP2086 Vaccine Elicits Broad and Robust Serum Bactericidal Responses in Healthy Adolescents

    DEFF Research Database (Denmark)

    Vesikari, Timo; Østergaard, Lars Jørgen; Diez-Domingo, Javier

    2015-01-01

    BACKGROUND: Neisseria meningitidis serogroup B (MnB) is a leading cause of invasive meningococcal disease in adolescents and young adults. A recombinant factor H binding protein (fHBP) vaccine (Trumenba(®); bivalent rLP2086) was recently approved in the United States in individuals aged 10-25 years....... Immunogenicity and safety of 2- or 3-dose schedules of bivalent rLP2086 were assessed in adolescents. METHODS: Healthy adolescents (11 to ... bactericidal antibody assay using human complement (hSBA). Safety assessments included local and systemic reactions and adverse events. RESULTS: Bivalent rLP2086 was immunogenic when administered as 2 or 3 doses; the most robust hSBA responses occurred with 3 doses. The proportion of subjects with hSBA titers...

  1. Analysis of error floor of LDPC codes under LP decoding over the BSC

    Energy Technology Data Exchange (ETDEWEB)

    Chertkov, Michael [Los Alamos National Laboratory; Chilappagari, Shashi [UNIV OF AZ; Vasic, Bane [UNIV OF AZ; Stepanov, Mikhail [UNIV OF AZ

    2009-01-01

    We consider linear programming (LP) decoding of a fixed low-density parity-check (LDPC) code over the binary symmetric channel (BSC). The LP decoder fails when it outputs a pseudo-codeword which is not a codeword. We propose an efficient algorithm termed the instanton search algorithm (ISA) which, given a random input, generates a set of flips called the BSC-instanton and prove that: (a) the LP decoder fails for any set of flips with support vector including an instanton; (b) for any input, the algorithm outputs an instanton in the number of steps upper-bounded by twice the number of flips in the input. We obtain the number of unique instantons of different sizes by running the ISA sufficient number of times. We then use the instanton statistics to predict the performance of the LP decoding over the BSC in the error floor region. We also propose an efficient semi-analytical method to predict the performance of LP decoding over a large range of transition probabilities of the BSC.

  2. LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-Glycan on Thr52 of Platelet Aggregation-Stimulating Domain of Human Podoplanin.

    Directory of Open Access Journals (Sweden)

    Yukinari Kato

    Full Text Available Podoplanin (PDPN, also known as Aggrus, possesses three tandem repeat of platelet aggregation-stimulating (PLAG domains in its N-terminus. Among the PLAG domains, sialylated O-glycan on Thr52 of PLAG3 is essential for the binding to C-type lectin-like receptor-2 (CLEC-2 and the platelet-aggregating activity of human PDPN (hPDPN. Although various anti-hPDPN monoclonal antibodies (mAbs have been generated, no specific mAb has been reported to target the epitope containing glycosylated Thr52. We recently established CasMab technology to develop mAbs against glycosylated membrane proteins. Herein, we report the development of a novel anti-glycopeptide mAb (GpMab, LpMab-12. LpMab-12 detected endogenous hPDPN by flow cytometry. Immunohistochemical analyses also showed that hPDPN-expressing lymphatic endothelial and cancer cells were clearly labeled by LpMab-12. The minimal epitope of LpMab-12 was identified as Asp49-Pro53 of hPDPN. Furthermore, LpMab-12 reacted with the synthetic glycopeptide of hPDPN, corresponding to 38-54 amino acids (hpp3854: 38-EGGVAMPGAEDDVVTPG-54, which carries α2-6 sialylated N-acetyl-D-galactosamine (GalNAc on Thr52. LpMab-12 did not recognize non-sialylated GalNAc-attached glycopeptide, indicating that sialylated GalNAc on Thr52 is necessary for the binding of LpMab-12 to hPDPN. Thus, LpMab-12 could serve as a new diagnostic tool for determining whether hPDPN possesses the sialylation on Thr52, a site-specific post-translational modification critical for the hPDPN association with CLEC-2.

  3. Convex Hypersurfaces and $L^p$ Estimates for Schr\\"odinger Equations

    OpenAIRE

    Zheng, Quan; Yao, Xiaohua; Fan, Da

    2004-01-01

    This paper is concerned with Schr\\"odinger equations whose principal operators are homogeneous elliptic. When the corresponding level hypersurface is convex, we show the $L^p$-$L^q$ estimate of solution operator in free case. This estimate, combining with the results of fractionally integrated groups, allows us to further obtain the $L^p$ estimate of solutions for the initial data belonging to a dense subset of $L^p$ in the case of integrable potentials.

  4. A review of progress with analysis of blowdown experiments using RELAP-UK

    International Nuclear Information System (INIS)

    Fayers, F.J.

    1975-10-01

    This paper briefly reviews some of the recent work at AEE Winfrith to establish the validity of the RELAP-UK code by comparison with blowdown experiments. Five sources of experimental data have been used which include two of the Edwards' simple pipe blowdown experiments, the LOFT semi-scale Benchmark Problem No. 2, and the Italian and Japanese blowdown rig results. Various difficulties in the comparison between theory and measurements are highlighted and the steps proposed to resolve the problems are indicated. (author)

  5. Protective effect of (-)-epigallocatechin gallate on ultraviolet b ...

    African Journals Online (AJOL)

    Chang Liu1, Xin-Qiang Zheng1, Li-Ping Xiang2, Jian-Liang Lu1, Curt ..... Fukunagam M, Tsuru K, Horikawa T. UV-induced skin ... Liang YR, Kang SY, Deng L, Xiang LP, Zheng XQ. ... Lee XZ, Liang YR, Chen H, Lu JL, Liang HL, Huang FP,.

  6. A spinach O-acetylserine(thiollyase homologue, SoCSaseLP, suppresses cysteine biosynthesis catalysed by other enzyme isoforms

    Directory of Open Access Journals (Sweden)

    Miki Noda

    2016-06-01

    Full Text Available An enzyme, O-acetylserine(thiollyase (OASTL, also known as O-acetylserine sulfhydrylase or cysteine synthase (CSase, catalyses the incorporation of sulfide into O-acetylserine and produces cysteine. We previously identified a cDNA encoding an OASTL-like protein from Spinacia oleracea, (SoCSaseLP, but a recombinant SoCSaseLP produced in Escherichia coli did not show OASTL activity. The exon-intron structure of the SoCSaseLP gene shared conserved structures with other spinach OASTL genes. The SoCSaseLP and a Beta vulgaris homologue protein, KMT13462, comprise a unique clade in the phylogenetic tree of the OASTL family. Interestingly, when the SoCSaseLP gene was expressed in tobacco plants, total OASTL activity in tobacco leaves was reduced. This reduction in total OASTL activity was most likely caused by interference by SoCSaseLP with cytosolic OASTL. To investigate the possible interaction of SoCSaseLP with a spinach cytosolic OASTL isoform SoCSaseA, a pull-down assay was carried out. The recombinant glutathione S-transferase (GST-SoCSaseLP fusion protein was expressed in E. coli together with the histidine-tagged SoCSaseA protein, and the protein extract was subjected to glutathione affinity chromatography. The histidine-tagged SoCSaseA was co-purified with the GST-SoCSaseLP fusion protein, indicating the binding of SoCSaseLP to SoCSaseA. Consistent with this interaction, the OASTL activity of the co-purified SoCSaseA was reduced compared with the activity of SoCSaseA that was purified on its own. These results strongly suggest that SoCSaseLP negatively regulates the activity of other cytosolic OASTL family members by direct interaction.

  7. The interplay of universities and industry through the FP5 network

    International Nuclear Information System (INIS)

    Almendral, Juan A; Oliveira, J G; Lopez, L; Sanjuan, Miguel A F; Mendes, J F F

    2007-01-01

    To improve the quality of life in a modern society it is essential to reduce the distance between basic research and applications, whose crucial roles in shaping today's society prompt us to seek their understanding. Existing studies on this subject, however, have neglected the network character of the interaction between universities and industry. Here we use state-of-the-art network theory methods to analyse this interplay in the so-called Framework Programme (FP)-an initiative which sets out the priorities for the European Union's research and technological development. In particular we study in the 5th FP (FP5) the role played by companies and scientific institutions and how they contribute to enhance the relationship between research and industry. Our approach provides quantitative evidence that while firms are size hierarchically organized, universities and research organizations keep the network from falling into pieces, paving the way for an effective knowledge transfer

  8. Optimal design for crosstalk analysis in 12-core 5-LP mode homogeneous multicore fiber for different lattice structure

    Science.gov (United States)

    Kumar, Dablu; Ranjan, Rakesh

    2018-03-01

    12-Core 5-LP mode homogeneous multicore fibers have been proposed for analysis of inter-core crosstalk and dispersion, with four different lattice structures (circular, 2-ring, square lattice, and triangular lattice) having cladding diameter of 200 μm and a fixed cladding thickness of 35 μm. The core-to-core crosstalk impact has been studied numerically with respect to bending radius, core pitch, transmission distance, wavelength, and core diameter for all 5-LP modes. In anticipation of further reduction in crosstalk levels, the trench-assisted cores have been incorporated for all respective designs. Ultra-low crosstalk (-138 dB/100 km) has been achieved through the triangular lattice arrangement, with trench depth Δ2 = -1.40% for fundamental (LP01) mode. It has been noted that the impact of mode polarization on crosstalk behavior is minor, with difference in crosstalk levels between two polarized spatial modes as ≤0.2 dB. Moreover, the optimized cladding diameter has been obtained for all 5-LP modes for a target value of crosstalk of -50 dB/100 km, with all the core arrangements. The dispersion characteristic has also been analyzed with respect to wavelength, which is nearly 2.5 ps/nm km at operating wavelength 1550 nm. The relative core multiplicity factor (RCMF) for the proposed design is obtained as 64.

  9. LP (a) levels and apo (a) phenotypes in urban black South African ...

    African Journals Online (AJOL)

    300 U/I), intermediate (300 - 700 UII) and high (> 700 UII) plasma Lp (a) ... Tygerberg Hospital, Tygerberg, W Cape ... up to 200-fold difference in Lp (a) concentrations.' In addition, ethnic .... An interesting observation was the large number of phenotypes, Le. ... sample of black Americans with a high-resolution SOS- agarose ...

  10. Simulations of the x-ray imaging capabilities of the silicon drift detectors (SDD) for the LOFT wide-field monitor

    DEFF Research Database (Denmark)

    Evangelista, Y.; Campana, R.; Del Monte, E.

    2012-01-01

    Detector (LAD), carrying an unprecedented effective area of 10 m^2, is complemented by a coded-mask Wide Field Monitor, in charge of monitoring a large fraction of the sky potentially accessible to the LAD, to provide the history and context for the sources observed by LAD and to trigger its observations...... on their most interesting and extreme states. In this paper we present detailed simulations of the imaging capabilities of the Silicon Drift Detectors developed for the LOFT Wide Field Monitor detection plane. The simulations explore a large parameter space for both the detector design and the environmental...

  11. Analysis of heat transfer from fuel rods with externally attached thermocouples

    International Nuclear Information System (INIS)

    Gill, C.R.; Coddington, P.

    1988-05-01

    This paper describes the development of 2 and 3 dimensional finite element heat conduction models to simulate the behaviour of the external thermocouples attached to the LOFT fuel rods during the blowdown phase of a large break loss-of-coolant accident. To establish the model and determine the thermal coupling between the thermocouple and the fuel rod extensive use was made of two series of experiments performed at INEL in the LOFT Test Support Facility (LTSF). These experiments were high pressure reflood experiments with fluid conditions 'typical' of those seen during the bottom-up flow period of the LOFT experiments. (author)

  12. Photon and decay data libraries for ORIGEN2 code based on JENDL FP decay data file 2000

    CERN Document Server

    Katakura, J I

    2002-01-01

    Photon and decay data libraries for the ORIGEN2 code have been updated by using JENDL FP Decay Data File 2000 (JENDL/FPD-00). As for the decay data, half-lives, branching ratios and recoverable energy values have been replaced with those of the JENDL/FPD-00 file. The data of the photon library has been also replaced with those of the JENDL/FPD-00 file in which photon data of the nuclides without measured data are calculated with a theoretical method. Using the updated photon library, the calculation of photon spectrum at a short time after fission event is able to be made.

  13. The short range effective interaction and the spectra of calcium isotopes in (f-p) space

    International Nuclear Information System (INIS)

    Qing-ying, Z.; Shen-wu, L.; Jian-xin, W.

    1986-01-01

    In this work, the authors use a new type of extremely short range interaction, the double delta interaction (DDI) to calculate the low-lying spectra of calcium isotopes /sup 41/Ca through /sup 48/Ca. The configuration space (f-p) includes configurations ( f/sub 7/2//sup n/ ) and ( f/sub 7/2//sup n-1/2p/sub 3/2/). The calculated energies are compared with experimental data for 75 levels. For comparison, they also use usual modified surface delta interaction (MSDI) to calculate the same spectra aforementioned. It is clear that the results calculated with DDI are better than with MSDI. Therefore, in the short-range effective interaction the addition of body delta force to the modified surface delta force may improve the agreement with experiment. The authors believe that the conclusion will not be changed if one enlarges the shell model space

  14. 65 nm LP/GP mix low cost platform for multi-media wireless and consumer applications

    Science.gov (United States)

    Tavel, B.; Duriez, B.; Gwoziecki, R.; Basso, M. T.; Julien, C.; Ortolland, C.; Laplanche, Y.; Fox, R.; Sabouret, E.; Detcheverry, C.; Boeuf, F.; Morin, P.; Barge, D.; Bidaud, M.; Biénacel, J.; Garnier, P.; Cooper, K.; Chapon, J. D.; Trouiller, Y.; Belledent, J.; Broekaart, M.; Gouraud, P.; Denais, M.; Huard, V.; Rochereau, K.; Difrenza, R.; Planes, N.; Marin, M.; Boret, S.; Gloria, D.; Vanbergue, S.; Abramowitz, P.; Vishnubhotla, L.; Reber, D.; Stolk, P.; Woo, M.; Arnaud, F.

    2006-04-01

    A complete 65 nm CMOS platform, called LP/GP Mix, has been developed employing thick oxide transistor (IO), Low Power (LP) and General Purpose (GP) devices on the same chip. Dedicated to wireless multi-media and consumer applications, this new triple gate oxide platform is low cost (+1mask only) and saves over 35% of dynamic power with the use of the low operating voltage GP. The LP/GP mix shows competitive digital performance with a ring oscillator (FO = 1) speed equal to 7 ps per stage (GP) and 6T-SRAM static power lower than 10 pA/cell (LP). Compatible with mixed-signal design requirements, transistors show high voltage gain, low mismatch factor and low flicker noise. Moreover, to address mobile phone demands, excellent RF performance has been achieved with FT = 160 GHz for LP and 280 GHz for GP nMOS transistors.

  15. File Specification for GEOS-5 FP (Forward Processing)

    Science.gov (United States)

    Lucchesi, R.

    2013-01-01

    The GEOS-5 FP Atmospheric Data Assimilation System (GEOS-5 ADAS) uses an analysis developed jointly with NOAA's National Centers for Environmental Prediction (NCEP), which allows the Global Modeling and Assimilation Office (GMAO) to take advantage of the developments at NCEP and the Joint Center for Satellite Data Assimilation (JCSDA). The GEOS-5 AGCM uses the finite-volume dynamics (Lin, 2004) integrated with various physics packages (e.g, Bacmeister et al., 2006), under the Earth System Modeling Framework (ESMF) including the Catchment Land Surface Model (CLSM) (e.g., Koster et al., 2000). The GSI analysis is a three-dimensional variational (3DVar) analysis applied in grid-point space to facilitate the implementation of anisotropic, inhomogeneous covariances (e.g., Wu et al., 2002; Derber et al., 2003). The GSI implementation for GEOS-5 FP incorporates a set of recursive filters that produce approximately Gaussian smoothing kernels and isotropic correlation functions. The GEOS-5 ADAS is documented in Rienecker et al. (2008). More recent updates to the model are presented in Molod et al. (2011). The GEOS-5 system actively assimilates roughly 2 × 10(exp 6) observations for each analysis, including about 7.5 × 10(exp 5) AIRS radiance data. The input stream is roughly twice this volume, but because of the large volume, the data are thinned commensurate with the analysis grid to reduce the computational burden. Data are also rejected from the analysis through quality control procedures designed to detect, for example, the presence of cloud. To minimize the spurious periodic perturbations of the analysis, GEOS-5 FP uses the Incremental Analysis Update (IAU) technique developed by Bloom et al. (1996). More details of this procedure are given in Appendix A. The assimilation is performed at a horizontal resolution of 0.3125-degree longitude by 0.25- degree latitude and at 72 levels, extending to 0.01 hPa. All products are generated at the native resolution of the

  16. Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease

    International Nuclear Information System (INIS)

    Spiegel, J.; Fassbender, K.; Dillmann, U.; Hellwig, D.; Samnick, S.; Moellers, M.-O.; Kirsch, C.-M.; Jost, W.

    2007-01-01

    In idiopathic Parkinson's disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I- 123 ]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p 0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor. (author)

  17. The interplay of universities and industry through the FP5 network

    Energy Technology Data Exchange (ETDEWEB)

    Almendral, Juan A [Departamento de Fisica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain); Oliveira, J G [Departamento de Fisica, Universidade de Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal); Lopez, L [Departamento de IngenierIa Telematica y TecnologIa Electronica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain); Sanjuan, Miguel A F [Departamento de Fisica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain); Mendes, J F F [Departamento de Fisica, Universidade de Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal)

    2007-06-15

    To improve the quality of life in a modern society it is essential to reduce the distance between basic research and applications, whose crucial roles in shaping today's society prompt us to seek their understanding. Existing studies on this subject, however, have neglected the network character of the interaction between universities and industry. Here we use state-of-the-art network theory methods to analyse this interplay in the so-called Framework Programme (FP)-an initiative which sets out the priorities for the European Union's research and technological development. In particular we study in the 5th FP (FP5) the role played by companies and scientific institutions and how they contribute to enhance the relationship between research and industry. Our approach provides quantitative evidence that while firms are size hierarchically organized, universities and research organizations keep the network from falling into pieces, paving the way for an effective knowledge transfer.

  18. Capped Lp approximations for the composite L0 regularization problem

    OpenAIRE

    Li, Qia; Zhang, Na

    2017-01-01

    The composite L0 function serves as a sparse regularizer in many applications. The algorithmic difficulty caused by the composite L0 regularization (the L0 norm composed with a linear mapping) is usually bypassed through approximating the L0 norm. We consider in this paper capped Lp approximations with $p>0$ for the composite L0 regularization problem. For each $p>0$, the capped Lp function converges to the L0 norm pointwisely as the approximation parameter tends to infinity. We point out tha...

  19. Survival associated pathway identification with group Lp penalized global AUC maximization

    Directory of Open Access Journals (Sweden)

    Liu Zhenqiu

    2010-08-01

    Full Text Available Abstract It has been demonstrated that genes in a cell do not act independently. They interact with one another to complete certain biological processes or to implement certain molecular functions. How to incorporate biological pathways or functional groups into the model and identify survival associated gene pathways is still a challenging problem. In this paper, we propose a novel iterative gradient based method for survival analysis with group Lp penalized global AUC summary maximization. Unlike LASSO, Lp (p 1. We first extend Lp for individual gene identification to group Lp penalty for pathway selection, and then develop a novel iterative gradient algorithm for penalized global AUC summary maximization (IGGAUCS. This method incorporates the genetic pathways into global AUC summary maximization and identifies survival associated pathways instead of individual genes. The tuning parameters are determined using 10-fold cross validation with training data only. The prediction performance is evaluated using test data. We apply the proposed method to survival outcome analysis with gene expression profile and identify multiple pathways simultaneously. Experimental results with simulation and gene expression data demonstrate that the proposed procedures can be used for identifying important biological pathways that are related to survival phenotype and for building a parsimonious model for predicting the survival times.

  20. [Development of a Striatal and Skull Phantom for Quantitative 123I-FP-CIT SPECT].

    Science.gov (United States)

    Ishiguro, Masanobu; Uno, Masaki; Miyazaki, Takuma; Kataoka, Yumi; Toyama, Hiroshi; Ichihara, Takashi

    123 Iodine-labelled N-(3-fluoropropyl) -2β-carbomethoxy-3β-(4-iodophenyl) nortropane ( 123 I-FP-CIT) single photon emission computerized tomography (SPECT) images are used for differential diagnosis such as Parkinson's disease (PD). Specific binding ratio (SBR) is affected by scattering and attenuation in SPECT imaging, because gender and age lead to changes in skull density. It is necessary to clarify and correct the influence of the phantom simulating the the skull. The purpose of this study was to develop phantoms that can evaluate scattering and attenuation correction. Skull phantoms were prepared based on the measuring the results of the average computed tomography (CT) value, average skull thickness of 12 males and 16 females. 123 I-FP-CIT SPECT imaging of striatal phantom was performed with these skull phantoms, which reproduced normal and PD. SPECT images, were reconstructed with scattering and attenuation correction. SBR with partial volume effect corrected (SBR act ) and conventional SBR (SBR Bolt ) were measured and compared. The striatum and the skull phantoms along with 123 I-FP-CIT were able to reproduce the normal accumulation and disease state of PD and further those reproduced the influence of skull density on SPECT imaging. The error rate with the true SBR, SBR act was much smaller than SBR Bolt . The effect on SBR could be corrected by scattering and attenuation correction even if the skull density changes with 123 I-FP-CIT on SPECT imaging. The combination of triple energy window method and CT-attenuation correction method would be the best correction method for SBR act .

  1. State of the Art in LP-WAN Solutions for Industrial IoT Services.

    Science.gov (United States)

    Sanchez-Iborra, Ramon; Cano, Maria-Dolores

    2016-05-17

    The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN), is explored. By means of a cellular-type architecture, LP-WAN-based solutions aim at fulfilling the reliability and efficiency challenges posed by long-term industrial networks. Thus, the most prominent LP-WAN solutions are reviewed, identifying and discussing the pros and cons of each of them. The focus is also on examining the current deployment state of these platforms in Spain. Although LP-WAN systems are at early stages of development, they represent a promising alternative for boosting future industrial IIoT (Industrial Internet of Things) networks and services.

  2. State of the Art in LP-WAN Solutions for Industrial IoT Services

    Directory of Open Access Journals (Sweden)

    Ramon Sanchez-Iborra

    2016-05-01

    Full Text Available The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN, is explored. By means of a cellular-type architecture, LP-WAN–based solutions aim at fulfilling the reliability and efficiency challenges posed by long-term industrial networks. Thus, the most prominent LP-WAN solutions are reviewed, identifying and discussing the pros and cons of each of them. The focus is also on examining the current deployment state of these platforms in Spain. Although LP-WAN systems are at early stages of development, they represent a promising alternative for boosting future industrial IIoT (Industrial Internet of Things networks and services.

  3. Clinical studies of 18F-FDG and 18F-FP-β-CIT PET imaging in hemi-Parkinson's disease

    International Nuclear Information System (INIS)

    Zhao Jun; Lin Xiangtong; Guan Yihui; Zuo Chuantao; Zhang Zhengwei; Wang Jian; Sun Bomin; Chen Zhengping

    2003-01-01

    Objective: To study the characteristics of 18 F-fluorodeoxyglucose (FDG) and 18 F-N-3-fluoro-propyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ( 18 F-FP-β-CIT) PET imaging in patients with hemi-Parkinson's disease (hemi-PD) and to assess their value in early diagnosis. Methods: 34 cases of hemi-PD (Hoehn and Yahr stage I-II) and 16 normal control subjects were selected for this study. 16 patients were performed with 18 F-FDG PET imaging, 18 patients with 18 F-FP-β-CIF, while 6 patients of them both 18 F-FDG and 18 F-FP-β-CIT. 30 min after injection of 185-259 MBq 18 F-FDG, 3D brain scans were acquired. Region of interest (ROI) analysis and statistical parametric mapping (SPM) were applied. 18 F-FP-β-CIT PET imaging was carried out 2-3 h post injection, and (ROI-cerebellum)/cerebellum ratio was calculated. Results: In right hemi-PD, reductions in 18 F-FDG metabolism were observed in the left basal ganglia compared with control group, but with no significant difference (P>0.05). The results of SPM analysis showed that a significant reduction in FDG uptake in the left superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus and left middle temporal gyrus, whereas a significant increase in the bilateral precentral gyrus , superior parietal lobule, left middle occipital gyrus and left thalamus as compared with the control group. There was a significant reduction in 18 F-FP-β-CIT uptake in putamen, its reduction was found not only in the contralateral putamen, but also in the ipsilateral ones, and more pronounced in the contralateral posterior putamen. Conclusions: 18 F-FDG PET imaging is non-specific for the early diagnosis of PD. 18 F-FP-β-CIT PET imaging could find the changes of striatum dopamine transporter at early stage, therefore it was helpful for early diagnosis and differential diagnosis of PD. Combined with 18 F-FDG PET imaging, the changes of local cerebral glucose metabolism in PD could also be evaluated

  4. Carbonate Precipitates During Heat Evolution in FP-Type Cells

    International Nuclear Information System (INIS)

    Bruce L. Cain

    2000-01-01

    In previous work, we reported measurement of large amounts of heat generated during experiments using an FP-type open cell with concentrated LiOH/D 2 O electrolytes and thin-film Pd cathodes. During the heat evolution in several runs, which produced >100 W for more than 20 h, we consistently observed the concomitant evolution of gases from the electrolyte and the precipitation of large amounts of lithium carbonate. The carbonate production was clearly visible during production of heat, creating an opaque electrolyte even during long periods with no electrolysis current. These results indicated an unusual chemical reaction, either catalyzed by the heating process or possibly creating the heat itself. The total energy released during the earlier experiments was ∼7 MJ, while the heat of formation for the lithium carbonate in the cell was only 0.8 MJ. Hence, only ∼10% of the heat signatures from these experiments can be attributed to the precipitate formation, the balance of the heat presumably arising from nonchemical sources in the cells. The earlier experiments that produced heat also suffered from problems of reproducibility, with only 5 of 38 runs producing any heat at all. The unsuccessful runs also did not produce precipitates, and the only gas produced in these cells was due to the normal electrolysis of D 2 O to produce oxygen and deuterium in the electrodes. Recent work has focused on recreating the chemical precipitation reaction, in efforts to understand and/or trigger the heat production process. With findings from these experiments, new experiments were conducted using larger (1 L LiOH/D 2 O) cells with Pt anodes and Pd film cathodes immersed but left open-circuited. After the addition of H 2 O 2 , and subsequent heating and cooling, these cells visually reproduced the precipitation and gas evolution of the earlier heat-producing runs. However, these new runs only produced a few watts of power for several minutes, consistent with the normal exothermal

  5. An LP-based heuristic for the fixed charge transportation problem

    DEFF Research Database (Denmark)

    Klose, Andreas

    2007-01-01

    The fixed charge transportation problem consists in finding a minimum cost network flow from a set of suppliers to a set of customers. Beside costs proportional to quantities transported, transportation costs also include a fixed charge. The paper describes a linear programming based heuristic...... approach for computing lower and upper bounds on the minimal cost. To this end, the LP relaxation is iteratively strengthened by means of adding cuts; in each iteration the current LP solution is then used to guide a local search heuristic. In addition to standard polyhedral cuts as lifted cover...

  6. 78 FR 62614 - Guttman Energy, Inc., PBF Holding Company LLC v. Buckeye Pipe Line Company, L.P., Laurel Pipe...

    Science.gov (United States)

    2013-10-22

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. OR14-4-000] Guttman Energy, Inc., PBF Holding Company LLC v. Buckeye Pipe Line Company, L.P., Laurel Pipe Line Company, L.P... complaint against Buckeye Pipe Line Company L.P. and Laurel Pipe Line Company L.P. (Respondents) challenging...

  7. Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines

    International Nuclear Information System (INIS)

    Okada, Tomoya; Fujita, Masahiro; Shimada, Shoichi; Sato, Kohji; Schloss, Patrick; Watanabe, Yoshiyuki; Itoh, Yasushi; Tohyama, Masaya; Nishimura, Tsunehiko

    1998-01-01

    We investigated the effects of three cocaine analogs, beta-CIT (2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane), beta-CIT-FE (2-beta-carbomethoxy-3-beta-(4-iodophenyl)-N-(2-fluoroethyl)-nortropane), and beta-CIT-FP (2-beta-carbomethoxy-3-beta-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane), on the uptake of [ 3 H]dopamine(DA), serotonin(5-HT), and 1-norepinephrine (NE) using cell lines permanently expressing DA, 5-HT, and NE transporters, respectively, to determine their affinities for these three transporters. We generated cell lines stably expressing DA, 5-HT, and NE transporters, respectively, by the Chen-Okayama method, and then tested the abilities of (-)cocaine, beta-CIT, beta-CIT-FE, beta-CIT-FP, and clomipramine to inhibit the uptake of [ 3 H]DA, 5-HT, and 1-NE. Ki values of beta-CIT, beta-CIT-FE, and beta-CIT-FP for [ 3 H]DA, 5-HT, 1-NE uptake were 6, 29, and 33 nM, 91, 133, and 130 nM, and 28, 113 and 70 nM, respectively, whereas those of cocaine and clomipramine were 316, 581, and 176 nM and > 10,000, 437, and 851 nM, respectively. Beta-CIT, beta-CIT-FE, and beta-CIT-FP were shown to be potent DA, 5-HT, and NE uptake inhibitors. Beta-CIT and beta-CIT-FP were highly potent and selective dopamine uptake inhibitors, and therefore might be useful for imaging of DA transporter with single photon emission computed tomography (SPECT) or positron emission tomography (PET)

  8. Identification of a functional nuclear export signal in the green fluorescent protein asFP499

    International Nuclear Information System (INIS)

    Mustafa, Huseyin; Strasser, Bernd; Rauth, Sabine; Irving, Robert A.; Wark, Kim L.

    2006-01-01

    The green fluorescent protein (GFP) asFP499 from Anemonia sulcata is a distant homologue of the GFP from Aequorea victoria. We cloned the asFP499 gene into a mammalian expression vector and showed that this protein was expressed in the human lymphoblast cell line Ramos RA1 and in the embryonic kidney 293T cell line (HEK 293T). In HEK 293T cells, asFP499 was localized mainly in the cytoplasm, suggesting that the protein was excluded from the nucleus. We identified 194 LRMEKLNI 201 as a candidate nuclear export signal in asFP499 and mutated the isoleucine at position 201 to an alanine. Unlike the wildtype form, the mutant protein was distributed throughout the cytoplasm and nucleus. This is First report of a GFP that contains a functional NES

  9. Listening to people to cure people: the LpCp - tool, an instrument to evaluate hospital humanization.

    Science.gov (United States)

    Buffoli, M; Bellini, E; Bellagarda, A; Di Noia, M; Nickolova, M; Capolongo, S

    2014-01-01

    In the healthcare environment, nowadays, only a few among the available evaluation systems pay enough attention to certain social sustainability aspects. Among these, humanization plays a key role in an environment, like hospitals, where the mental and physical well-being of patients and healthcare operators is crucial. Our research project, known as 'SustHealth', is focused on the deficiencies of the evaluation methodology and aims at developing an assessment system related to a questionnaire-based investigation capable of revealing the most influential conditions and dynamics in people's hospital experience, while also recommending areas in hospitals where efforts can be made to sustain improvement strategies. The humanization of healthcare structures began with a significant investigation to assess all the major evaluation tools in both hospitals - to better understand the physical and emotional interactions in the structure-user ratio - and other areas. This helped understand the strengths and criticalities of the systems that were examined. This first step also allowed to shed light on the most important aspects to keep in mind when developing an evaluation system. During the operational steps an all-new LpCp - tool (Listening to people to Cure people) was created, which includes a questionnaire-based investigation and processing software, and its application for beta-testing in a 600-bed hospital in Milan. The LpCp - tool proved to be effective and capable of finding the deficiencies and potential in the examined hospital. Considering different themes through alternative viewpoints (staff, patients/visitors, technicians, etc.), the tool has allowed underlining different perceptions of the same place and also provided sound information to guide healthcare management in taking informed decisions about specific problems or users. Former interesting results show an inadequate appraisal about e.g. on-site facilities or recreational activities and a lack of

  10. No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle

    DEFF Research Database (Denmark)

    Miller, B.F.; Hansen, M.; Olesen, J.L.

    2006-01-01

    We tested the hypothesis that acute exercise would stimulate synthesis of myofibrillar protein and intramuscular collagen in women and that the phase of the menstrual cycle at which the exercise took place would influence the extent of the change. Fifteen young, healthy female subjects were studied...... in the follicular (FP, n=8) or the luteal phase (LP, n=7, n=1 out of phase) 24 h after an acute bout of one-legged exercise (60 min of kicking at 67% W(max)), samples being taken from the vastus lateralis in both the exercised and resting legs. Rates of synthesis of myofibrillar and muscle collagen proteins were...... measured by incorporation of [(13)C]leucine. Myofibrillar protein synthesis (means+/-SD; rest FP: 0.053+/-0.009%/h, LP: 0.055+/-0.013%/h) was increased at 24-h postexercise (FP: 0.131+/-0.018%/h, Psynthesis...

  11. Development of a methodology for conducting an integrated HRA/PRA --. Task 1, An assessment of human reliability influences during LP&S conditions PWRs

    Energy Technology Data Exchange (ETDEWEB)

    Luckas, W.J.; Barriere, M.T.; Brown, W.S. [Brookhaven National Lab., Upton, NY (United States); Wreathall, J. [Wreathall (John) and Co., Dublin, OH (United States); Cooper, S.E. [Science Applications International Corp., McLean, VA (United States)

    1993-06-01

    During Low Power and Shutdown (LP&S) conditions in a nuclear power plant (i.e., when the reactor is subcritical or at less than 10--15% power), human interactions with the plant`s systems will be more frequent and more direct. Control is typically not mediated by automation, and there are fewer protective systems available. Therefore, an assessment of LP&S related risk should include a greater emphasis on human reliability than such an assessment made for power operation conditions. In order to properly account for the increase in human interaction and thus be able to perform a probabilistic risk assessment (PRA) applicable to operations during LP&S, it is important that a comprehensive human reliability assessment (HRA) methodology be developed and integrated into the LP&S PRA. The tasks comprising the comprehensive HRA methodology development are as follows: (1) identification of the human reliability related influences and associated human actions during LP&S, (2) identification of potentially important LP&S related human actions and appropriate HRA framework and quantification methods, and (3) incorporation and coordination of methodology development with other integrated PRA/HRA efforts. This paper describes the first task, i.e., the assessment of human reliability influences and any associated human actions during LP&S conditions for a pressurized water reactor (PWR).

  12. 76 FR 29234 - Texas Eastern Transmission, LP; Notice of Request Under Blanket Authorization

    Science.gov (United States)

    2011-05-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-477-000] Texas Eastern Transmission, LP; Notice of Request Under Blanket Authorization Take notice that on May 10, 2011 Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in Docket No. CP11-477-000...

  13. 77 FR 64767 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2012-10-23

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... airworthiness directive (AD) for certain Gulfstream Aerospace LP (Type Certificate previously held by Israel... Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes...

  14. 78 FR 47546 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2013-08-06

    ... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model... Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli...

  15. HCDA bubble experiment, (2)

    International Nuclear Information System (INIS)

    Sakata, Kaoru; Mashiko, Hiroyuki; Oka, Yoshiaki; An, Shigehiro; Isozaki, Tadashi.

    1981-06-01

    An experiment simulating the behavior of the very large steam bubbles generated at the time of an accident of core collapse was carried out with a warm water tank, and the applicability of the theory of very small bubble disappearance known at present was examined. The bubbles generated in HCDA (hypothetical core disruptive accident) are expected to be very large, containing sodium, fuel, FP gas and so on, and play important role in the mechanism of emitting radioactive substances in the safety analysis of LMFBRs. In this experiment, the degree of subcool of the warm water pool, the initial radii of steam bubbles and the blowoff pressure of steam were taken as the parameters. The radius of the steam bubbles generated in the experiment was about 6.5 cm, and the state of disappearance was different above and below the degree of unsaturation of 10 deg C. Comparing the disappearance curve obtained by the experiment with the theory of disappearance of small bubbles, the experimental values were between inertia-controlled disappearance and heat transfer-controlled disappearance, and this result was able to be explained generally with the model taking the pressure change within steam bubbles into account. The rise of bubbles was also observed. (Kako, I.)

  16. 75 FR 28485 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2010-05-21

    ... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39... previously held by Israel Aircraft Industries, Ltd.) Model Gulfstream 100 airplanes; and Model Astra SPX and...

  17. 2nd FP7 Conference and International Summer School Nanotechnology : From Fundamental Research to Innovations

    CERN Document Server

    Yatsenko, Leonid

    2015-01-01

    This book presents some of the latest achievements in nanotechnology and nanomaterials from leading researchers in Ukraine, Europe, and beyond. It features contributions from participants in the 2nd International Summer School “Nanotechnology: From Fundamental Research to Innovations” and International Research and Practice Conference “Nanotechnology and Nanomaterials”, NANO-2013, which were held in Bukovel, Ukraine on August 25-September 1, 2013. These events took place within the framework of the European Commission FP7 project Nanotwinning, and were organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), University of Turin (Italy), and Pierre and Marie Curie University (France). Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results on topics ranging from nanooptics, nanoplasmonics, and interface studies to energy storage and biomedical applications. Pr...

  18. Applications research in ultrasonic testing of carbon fiber composite based on an optical fiber F-p sensor

    Science.gov (United States)

    Shan, Ning

    2016-10-01

    Carbon fiber composite is widely applied to the field of aerospace engineering because of its excellent performance. But it will be able to form more defects in the process of manufacturing inevitably on account of unique manufacturing process. Meanwhile it has sophisticated structure and services in the bad environment long time. The existence of defects will be able to cause the sharp decline in component's performance when the defect accumulates to a certain degree. So the reliability and safety test demand of carbon fiber composite is higher and higher. Ultrasonic testing technology is the important means used for characteristics of component inspection of composite materials. Ultrasonic information detection uses acoustic transducer generally. It need coupling agent and is higher demand for the surface of sample. It has narrow frequency band and low test precision. The extrinsic type optical fiber F-P interference cavity structure is designed to this problem. Its optical interference model is studied. The initial length of F-P cavity is designed. The realtime online detection system of carbon fiber composite is established based on optical fiber F-P Ultrasound sensing technology. Finally, the testing experiment study is conducted. The results show that the system can realize real-time online detection of carbon fiber composite's defect effectively. It operates simply and realizes easily. It has low cost and is easy to practical engineering.

  19. Smell of danger: an analysis of LP-gas odorization

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.S.; Turk, A.

    1985-03-01

    LP-gas derives warning properties from the odorants ethyl mercaptan or thiophane. Laboratory tests have implied that the average person has the ability to smell the odors before leaking LP-gas reaches one-fifth its lower limit of flammability. Generally, however, laboratory tests ignore or discard persons with a poor sense of smell, especially the elderly and persons with certain types of hyposmia. Some persons who apparently can smell the warning agents when directed may otherwise fail to notice or identify them. Elderly men seem particularly vulnerable to instances of incidental anosmia and olfactory agnosia. Psychophysical testing of the warning agents has been rather unsophisticated. There exists neither a standard protocol for testing nor adequate specification of the perceptual properties that might make one warning agent better than another. Without such developments, improvement in warning agents will fail to occur. Possible improvements include increases in concentration, the use of blends to insure more uniform delivery of agent and, to decrease the perceptual vulnerability of relatively insensitive people, use of agents with favorable psychophysical (stimulus-response) functions and use of agents with favorable adaptation characteristics. Even without a change in existing products, it seems advisable to learn more about the vulnerability of LP-gas users and to employ educational means to reduce risks.

  20. Comparative genome analysis of Lactobacillus plantarum GB-LP3 provides candidates of survival-related genetic factors.

    Science.gov (United States)

    Jeon, Soomin; Jung, Jaehoon; Kim, Kwondo; Yoo, DongAhn; Lee, Chanho; Kang, Jungsun; Cho, Kyungjin; Kang, Dae-Kyung; Kwak, Woori; Yoon, Sook Hee; Kim, Heebal; Cho, Seoae

    2017-09-01

    Lactobacillus plantarum is found in various environmental niches such as in the gastrointestinal tract of an animal host or a fermented food. This species isolated from a certain environment is known to possess a variety of properties according to inhabited environment's adaptation. However, a causal relationship of a genetic factor and phenotype affected by a specific environment has not been systematically comprehended. L. plantarum GB-LP3 strain was isolated from Korean traditional fermented vegetable and the whole genome of GB-LP3 was sequenced. Comparative genome analysis of GB-LP3, with other 14 L. plantarum strains, was conducted. In addition, genomic island regions were investigated. The assembled whole GB-LP3 genome contained a single circular chromosome of 3,206,111bp with the GC content of 44.7%. In the phylogenetic tree analysis, GB-LP3 was in the closest distance from ZJ316. The genomes of GB-LP3 and ZJ316 have the high level of synteny. Functional genes that are related to prophage, bacteriocin, and quorum sensing were found through comparative genomic analysis with ZJ316 and investigation of genomic islands. dN/dS analysis identified that the gene coding for phosphonate ABC transporter ATP-binding protein is evolutionarily accelerated in GB-LP3. Our study found that potential candidate genes that are affected by environmental adaptation in Korea traditional fermented vegetable. Copyright © 2017. Published by Elsevier B.V.

  1. 77 FR 44113 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2012-07-27

    ... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate previously held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... to the manufacturer. This action was prompted by a report from the Civil Aviation Authority of Israel...

  2. Lr-Lp Stability of the Incompressible Flows with Nonzero Far-Field Velocity

    Directory of Open Access Journals (Sweden)

    Jaiok Roh

    2011-01-01

    Full Text Available We consider the stability of stationary solutions w for the exterior Navier-Stokes flows with a nonzero constant velocity u∞ at infinity. For u∞=0 with nonzero stationary solution w, Chen (1993, Kozono and Ogawa (1994, and Borchers and Miyakawa (1995 have studied the temporal stability in Lp spaces for 11 and obtain Lr-Lp stability as Kozono and Ogawa and Borchers and Miyakawa obtained for u∞=0.

  3. The Leptospiral Antigen Lp49 is a Two-Domain Protein with Putative Protein Binding Function

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Giuseppe,P.; Oliveira Neves, F.; Nascimento, A.; Gomes Guimaraes, B.

    2008-01-01

    Pathogenic Leptospira is the etiological agent of leptospirosis, a life-threatening disease that affects populations worldwide. Currently available vaccines have limited effectiveness and therapeutic interventions are complicated by the difficulty in making an early diagnosis of leptospirosis. The genome of Leptospira interrogans was recently sequenced and comparative genomic analysis contributed to the identification of surface antigens, potential candidates for development of new vaccines and serodiagnosis. Lp49 is a membrane-associated protein recognized by antibodies present in sera from early and convalescent phases of leptospirosis patients. Its crystal structure was determined by single-wavelength anomalous diffraction using selenomethionine-labelled crystals and refined at 2.0 Angstroms resolution. Lp49 is composed of two domains and belongs to the all-beta-proteins class. The N-terminal domain folds in an immunoglobulin-like beta-sandwich structure, whereas the C-terminal domain presents a seven-bladed beta-propeller fold. Structural analysis of Lp49 indicates putative protein-protein binding sites, suggesting a role in Leptospira-host interaction. This is the first crystal structure of a leptospiral antigen described to date.

  4. 75 FR 8921 - Grant of Authority for Subzone Status; Brightpoint North America L.P. (Cell Phone Kitting and...

    Science.gov (United States)

    2010-02-26

    ... Status; Brightpoint North America L.P. (Cell Phone Kitting and Distribution) Indianapolis, IN Pursuant to... the cell phone kitting and distribution facilities of Brightpoint North America L.P., located in... cell phones at the facilities of Brightpoint North America L.P., located in Plainfield, Indiana...

  5. Introduction to linear programming: Coalitional game experiments

    Energy Technology Data Exchange (ETDEWEB)

    Lucas, W.

    1994-12-31

    Many solution notions in the multiperson cooperative games (in characteristic function form) make use of linear programming (LP). The popular concept of the {open_quotes}core{close_quotes} of a coalitional game is a special type of LP. It can be introduced in a very simple and quite exciting manner by means of a group experiment. A total of fifty dollars will be given to three randomly selected attendees who will take part in an experiment during this talk, presuming they behave in a Pareto optimal manner. Furthermore, the dual of the particular LP for the core gives rise to the idea of {open_quotes}balanced sets{close_quotes} which is an interesting combinatorial structure in its own right.

  6. Use of finger-prick dried blood spots (fpDBS) and capillary electrophoresis for carbohydrate deficient transferrin (CDT) screening in forensic toxicology.

    Science.gov (United States)

    Bertaso, Anna; Sorio, Daniela; Vandoros, Anthula; De Palo, Elio F; Bortolotti, Federica; Tagliaro, Franco

    2016-10-01

    Continued progress in chronic alcohol abuse investigation requires the development of less invasive procedures for screening purposes. The application of finger-prick and related dried blood spots (fpDBS) for carbohydrate deficient transferrin (CDT) detection appears suitable for this aim. Therefore, the goal of this project was to develop a screening method for CDT using fpDBS with CZE analysis. Blood samples prepared by finger-prick were placed on DBS cards and left to air dry; each dried fpDBS disc was shredded into small pieces and suspended in acid solution (60 μL of HCl 120 mmol/L). After centrifugation (10 min at 1500 × g), the collected sample was adjusted to pH 3.5. After an overnight incubation, the pH was neutralised and an iron rich solution was added. After 1 h, CZE analysis was carried out. A group of 47 individuals was studied. Parallel serum samples were collected from each investigated subject and the %CDT for each sample was measured using HPLC and CZE techniques. The fpDBS transferrin sialo isoform electropherograms were similar to those obtained with serum. Moreover, fpDBS CZE CDT percentage levels demonstrated significant statistical correlation with those obtained from serum for both HPLC and CZE %CDT (p < 0.01; r 2 = 0.8913 and 0.8976, respectively), with %CDT from 0.8 to 13.7% for fpDBS and from 0.7 to 12.7% for serum. The newly developed fpDBS procedure for CDT analysis provides a simple and inexpensive tool for use in population screening. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. The European FP7 ULTimateCO2 project: A comprehensive approach to study the long term fate of CO2 geological storage sites

    Science.gov (United States)

    Audigane, P.; Brown, S.; Dimier, A.; Pearce, J.; Frykman, P.; Maurand, N.; Le Gallo, Y.; Spiers, C. J.; Cremer, H.; Rutters, H.; Yalamas, T.

    2013-12-01

    The European FP7 ULTimateCO2 project aims at significantly advance our knowledge of specific processes that could influence the long-term fate of geologically stored CO2: i) trapping mechanisms, ii) fluid-rock interactions and effects on mechanical integrity of fractured caprock and faulted systems and iii) leakage due to mechanical and chemical damage in the well vicinity, iv) brine displacement and fluid mixing at regional scale. A realistic framework is ensured through collaboration with two demonstration sites in deep saline sandstone formations: the onshore former NER300 West Lorraine candidate in France (ArcelorMittal GeoLorraine) and the offshore EEPR Don Valley (former Hatfield) site in UK operated by National Grid. Static earth models have been generated at reservoir and basin scale to evaluate both trapping mechanisms and fluid displacement at short (injection) and long (post injection) time scales. Geochemical trapping and reservoir behaviour is addressed through experimental approaches using sandstone core materials in batch reactive mode with CO2 and impurities at reservoir pressure and temperature conditions and through geochemical simulations. Collection of data has been generated from natural and industrial (oil industry) analogues on the fluid flow and mechanical properties, structure, and mineralogy of faults and fractures that could affect the long-term storage capacity of underground CO2 storage sites. Three inter-related lines of laboratory experiments investigate the long-term evolution of the mechanical properties and sealing integrity of fractured and faulted caprocks using Opalinus clay of Mont Terri Gallery (Switzerland) (OPA), an analogue for caprock well investigated in the past for nuclear waste disposal purpose: - Characterization of elastic parameters in intact samples by measuring strain during an axial experiment, - A recording of hydraulic fracture flow properties by loading and shearing samples in order to create a 'realistic

  8. Preparation of lumped fission product (FP) cross sections for a multigroup library

    International Nuclear Information System (INIS)

    Ono, S.; Corcuera, R.P.

    1984-01-01

    A method for the calculation of lumped Fission Product (FP) cross sections has been developed. The group constants fo each nuclide are generated by NJOY code, based on ENDF/B-V data. In this first version, cross section of 28 nuclides are lumped for typical characteristics of Binary Breeder Reactor (BBR). One energy group calculations are made for a 1000 MWe fast reactor to verify the influence of burnup, number of FP and fuel composition on the lumped fission product cross sections. (Author) [pt

  9. 78 FR 11639 - Houston Pipe Line Company LP; Notice of Petition for Rate Approval

    Science.gov (United States)

    2013-02-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-31-000] Houston Pipe Line Company LP; Notice of Petition for Rate Approval Take notice that on February 1, 2013, Houston Pipe Line Company LP (HPL) filed for approval of rates for transportation service pursuant to section...

  10. Experiment data report for semiscale Mod-1 Test S-01-5 (isothermal blowdown with core resistance simulator)

    International Nuclear Information System (INIS)

    Zender, S.N.; Crapo, H.S.; Jensen, M.F.; Sackett, K.E.

    1975-04-01

    Recorded test data are presented for Test S-01-5 of the semiscale Mod-1 isothermal blowdown test series. Test S-01-5 is one of several semiscale Mod-1 experiments which are counterparts of the LOFT nonnuclear experiments. System hardware is representative of LOFT with the design based on volumetric scaling methods and with initial conditions duplicating those identified for LOFT nonnuclear tests. Test S-01-5 was conducted with the secondary side of the steam generator pressurized with nitrogen gas in order to effectively eliminate heat transfer from the steam generator during blowdown and thereby to investigate the effect on overall system behavior of heat transfer from the steam generator. An orificed structure was used in the pressure vessel to simulate the LOFT core simulator. The test was initiated at isothermal conditions of 2270 psig and 540 0 F by a simulated offset shear of the cold leg broken loop piping. During system depressurization, coolant was injected into the cold leg of the operating loop to simulate emergency core cooling (ECC). Following the blowdown portion of the test, coolant spray was introduced into the pressure suppression tank to determine the response of the pressure suppression system. The uninterpreted data from Test S-01-5 and the reference material needed for future data analysis and test results reporting activities are presented. The data, presented in the form of graphs in engineering units, have been analyzed only to the extent necessary to assure that they are reasonable and consistent. (U.S.)

  11. Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents.

    Science.gov (United States)

    Vesikari, Timo; Wysocki, Jacek; Beeslaar, Johannes; Eiden, Joseph; Jiang, Qin; Jansen, Kathrin U; Jones, Thomas R; Harris, Shannon L; O'Neill, Robert E; York, Laura J; Perez, John L

    2016-06-01

    Concomitant administration of bivalent rLP2086 (Trumenba [Pfizer, Inc] and diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) was immunologically noninferior to DTaP/IPV and saline and was safe and well tolerated. Bivalent rLP2086 elicited robust and broad bactericidal antibody responses to diverse Neisseria meningitidis serogroup B strains expressing antigens heterologous to vaccine antigens after 2 and 3 vaccinations. Bivalent rLP2086, a Neisseria meningitidis serogroup B (MnB) vaccine (Trumenba [Pfizer, Inc]) recently approved in the United States to prevent invasive MnB disease in individuals aged 10-25 years, contains recombinant subfamily A and B factor H binding proteins (fHBPs). This study evaluated the coadministration of Repevax (diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine [DTaP/IPV]) (Sanofi Pasteur MSD, Ltd) and bivalent rLP2086. Healthy adolescents aged ≥11 to B proteins different from the vaccine antigens. Participants were randomly assigned to receive bivalent rLP2086 + DTaP/IPV (n = 373) or saline + DTaP/IPV (n = 376). Immune responses to DTaP/IPV in participants who received bivalent rLP2086 + DTaP/IPV were noninferior to those in participants who received saline + DTaP/IPV.The proportions of bivalent rLP2086 + DTaP/IPV recipients with prespecified seroprotective hSBA titers to the 4 MnB test strains were 55.5%-97.3% after vaccination 2 and 81.5%-100% after vaccination 3. The administration of bivalent rLP2086 was well tolerated and resulted in few serious adverse events. Immune responses to DTaP/IPV administered with bivalent rLP2086 to adolescents were noninferior to DTaP/IPV administered alone. Bivalent rLP2086 was well tolerated and elicited substantial and broad bactericidal responses to diverse MnB strains in a high proportion of recipients after 2 vaccinations, and these responses were further enhanced after 3 vaccinations.ClinicalTrials.gov identifier NCT01323270

  12. Dry cooling tower operating experience in the LOFT reactor

    International Nuclear Information System (INIS)

    Hunter, J.A.

    1980-01-01

    A dry cooling tower has been uniquely utilized to dissipate heat generated in a small experimental pressurized water nuclear reactor. Operational experience revealed that dry cooling towers can be intermittently operated with minimal wind susceptibility and water hammer occurrences by cooling potential steam sources after a reactor scram, by isolating idle tubes from the external atmosphere, and by operating at relatively high pressures. Operating experience has also revealed that tube freezing can be minimized by incorporating the proper heating and heat loss prevention features

  13. THE RUNAWAY WHITE DWARF LP400-22 HAS A COMPANION

    International Nuclear Information System (INIS)

    Kilic, Mukremin; Brown, Warren R.; Kenyon, S. J.; Allende Prieto, Carlos; Swift, B.; Liebert, J.; Agueeros, M. A.

    2009-01-01

    We report the detection of a radial velocity companion to the extremely low-mass white dwarf (WD) LP400-22. The radial velocity of the WD shows variations with a semiamplitude of 119 km s -1 and a 0.98776 day period, which implies a companion mass of M ≥ 0.37 M sun . The optical photometry rules out a main-sequence companion. Thus the invisible companion is another WD or a neutron star. Using proper-motion measurements and the radial velocity of the binary system, we find that it has an unusual Galactic orbit. LP400-22 is moving away from the Galactic center with a velocity of 396 ± 43 km s -1 , which is very difficult to explain by supernova runaway ejection mechanisms. Dynamical interactions with a massive black hole like that in the Galactic center can in principle explain its peculiar velocity, if the progenitor was a triple star system comprised of a close binary and a distant tertiary companion. Until better proper motions become available, we consider LP400-22 to be most likely a halo star with a very unusual orbit.

  14. LP-tee pikeneb Tartust Pärnuni / Sirje Pärismaa

    Index Scriptorium Estoniae

    Pärismaa, Sirje, 1958-

    2015-01-01

    Norrast pärit tõenduspõhist koostöökultuuri arendava LP-mudeliga (learning environment and pedagogical analysis) on liitumas seitse kooli Pärnust, Viljandist, Puhjast, Tartust ning kolm lasteaeda

  15. Validation of MORET 4 perturbation against 'physical' type fission products experiments

    International Nuclear Information System (INIS)

    Anno, Jacques; Jacquet, Olivier; Miss, Joachim

    2003-01-01

    After shortly recalling one among the many pertinent recent features of the French criticality CRISTAL package i.e. the perturbation algorithm (so called MORET 4 'Perturbation' or MP), this paper presents original MP validations. Numerical and experimental validations are made using close fission products (FP) experiments. As results, it is shown that, all being equal, MP can detect FP's absorption cross-section variations in the range 0.3-1.2%. (author)

  16. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis

    DEFF Research Database (Denmark)

    Costa, D J; Marteau, P; Amouyal, M

    2014-01-01

    BACKGROUND/OBJECTIVES: An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out in pat...

  17. JENDL FP decay data file 2000 and the beta-decay theory

    International Nuclear Information System (INIS)

    Yoshida, Tadashi; Katakura, Jun Ichi; Tachibana, Takahiro

    2002-01-01

    JENDL FP Decay Data File 2000 has been developed as one of the special purpose files of the Japanese Evaluated Nuclear Data Library (JENDL), which constitutes a versatile nuclear data basis for science and technology. In the format of ENDF-6 this file includes the decay data for 1087 unstable fission product (FP) nuclides and 142 stable nuclides as their daughters. The primary purpose of this file is to use in the summation calculation of FP decay heat, which plays a critical role in nuclear safety analysis; the loss-of-coolant accident analysis of reactors, for example. The data for a given nuclide are its decay modes, the Q value, the branching ratios, the average energies released in the form of beta- and gamma-rays per decay, and their spectral data. The primary source of the decay data adopted here is the ENSDF (Evaluated Nuclear Structure Data File). The data in ENSDF, however, cover only the measured values. The data of the short-lived nuclides, which are essential for the decay heat calculations at short cooling times, are often fully lacking or incomplete even if they exist. This is mainly because of their short half-life nature. For such nuclides a theoretical model calculation is applied in order to fill the gaps between the true and the experimentally known decay schemes. In practice we have to predict the average decay energies and the spectral data for a lot of short-lived FPs by use of beta-decay theories. Thus the beta-decay theory plays a very important role in generating the FP decay data file

  18. 75 FR 14644 - Gemini Investors IV, L.P., Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2010-03-26

    ... SMALL BUSINESS ADMINISTRATION [License No. 01/01-0410] Gemini Investors IV, L.P., Notice Seeking... given that Gemini Investors IV, L.P., 20 William Street, Wellesley, MA 02481, a Federal Licensee under... Regulations (13 CFR 107.730). Gemini Investors IV, L.P. proposes to provide equity and debt financing to...

  19. Rotational order–disorder structure of fluorescent protein FP480

    International Nuclear Information System (INIS)

    Pletnev, Sergei; Morozova, Kateryna S.; Verkhusha, Vladislav V.; Dauter, Zbigniew

    2009-01-01

    An analysis of the rotational order–disorder structure of fluorescent protein FP480 is presented. In the last decade, advances in instrumentation and software development have made crystallography a powerful tool in structural biology. Using this method, structural information can now be acquired from pathological crystals that would have been abandoned in earlier times. In this paper, the order–disorder (OD) structure of fluorescent protein FP480 is discussed. The structure is composed of tetramers with 222 symmetry incorporated into the lattice in two different ways, namely rotated 90° with respect to each other around the crystal c axis, with tetramer axes coincident with crystallographic twofold axes. The random distribution of alternatively oriented tetramers in the crystal creates a rotational OD structure with statistically averaged I422 symmetry, although the presence of very weak and diffuse additional reflections suggests that the randomness is only approximate

  20. Dynamic Assessment of Seismic Risk (DASR) by Multi-parametric Observations: Preliminary Results of PRIME experiment within the PRE-EARTHQUAKES EU-FP7 Project

    Science.gov (United States)

    Tramutoli, V.; Inan, S.; Jakowski, N.; Pulinets, S. A.; Romanov, A.; Filizzola, C.; Shagimuratov, I.; Pergola, N.; Ouzounov, D. P.; Papadopoulos, G. A.; Parrot, M.; Genzano, N.; Lisi, M.; Alparlsan, E.; Wilken, V.; Tsybukia, K.; Romanov, A.; Paciello, R.; Zakharenkova, I.; Romano, G.

    2012-12-01

    The integration of different observations together with the refinement of data analysis methods, is generally expected to improve our present knowledge of preparatory phases of earthquakes and of their possible precursors. This is also the main goal of PRE-EARTHQUAKES (Processing Russian and European EARTH observations for earthQUAKE precursors Studies) the FP7 Project which, to this aim, committed together, different international expertise and observational capabilities, in the last 2 years. In the learning phase of the project, different parameters (e.g. thermal anomalies, total electron content, radon concentration, etc.), measured from ground and satellite systems and analyzed by using different data analysis approaches, have been studied for selected geographic areas and specific seismic events in the past. Since July 2012 the PRIME (PRE-EARTHQUAKES Real-time Integration and Monitoring Experiment) started attempting to perform, on the base of independent observations collected and integrated in real-time through the PEG (PRE-EARTHQUAKES Geo-portal), a Dynamic Assessment of Seismic Risk (DASR) on selected geographic areas of Europe (Italy-Greece-Turkey) and Asia (Kamchatka, Sakhalin, Japan). In this paper, results so far achieved as well as the potential and opportunities they open for a worldwide Earthquake Observation System (EQuOS) - as a dedicated component of GEOSS (Global Earth Observation System of Systems) - will be presented.

  1. Lithium in LP944-20

    Science.gov (United States)

    Pavlenko, Ya. V.; Jones, H. R. A.; Martín, E. L.; Guenther, E.; Kenworthy, M. A.; Zapatero Osorio, M. R.

    2007-09-01

    We present a new estimate of the lithium abundance in the atmosphere of the brown dwarf LP944-20. Our analysis is based on a self-consistent analysis of low-, intermediate- and high-resolution optical and near-infrared spectra. We obtain logN(Li) = 3.25 +/- 0.25 using fits of our synthetic spectra to the LiI resonance line doublet profiles observed with Very Large Telescope/Ultraviolet-Visual Echelle Spectrograph (VLT/UVES) and Anglo-Australian Telescope/Segmented Pupil/Image Reformatting Array of Lenslets (AAT/SPIRAL). This lithium abundance is over two orders of magnitude larger than previous estimates in the literature. In order to obtain good fits of the resonance lines of KI and RbI and better fits to the TiO molecular absorption around the LiI resonance line, we invoke a semi-empirical model atmosphere with the dusty clouds located above the photosphere. The lithium abundance, however, is not changed by the effects of the dusty clouds. We discuss the implications of our estimate of the lithium abundance in LP944-20 for the understanding of the properties of this benchmark brown dwarf. Based on observations obtained on the European Southern Observatory at Cerro Paranal, Chile, in programs 68.C-0063(A) and 072.C-0110(B), the Anglo-Australian Telescope at Siding Springs Observatory during commissioning observations for SPIRAL (Segmented Pupil/Image Reformatting Array of Lenslets) instrument and the Keck Observatory in Mauna Kea, Hawaii. E-mail: yp@mao.kiev.ua

  2. Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.

    Science.gov (United States)

    Szymula, Agnieszka; Palermo, Richard D; Bayoumy, Amr; Groves, Ian J; Ba Abdullah, Mohammed; Holder, Beth; White, Robert E

    2018-02-01

    The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vitro. We generated EBNA-LP knockout (LPKO) EBVs containing a STOP codon within each repeat unit of internal repeat 1 (IR1). EBNA-LP-mutant EBVs established lymphoblastoid cell lines (LCLs) from adult B cells at reduced efficiency, but not from umbilical cord B cells, which died approximately two weeks after infection. Adult B cells only established EBNA-LP-null LCLs with a memory (CD27+) phenotype. Quantitative PCR analysis of virus gene expression after infection identified both an altered ratio of the EBNA genes, and a dramatic reduction in transcript levels of both EBNA2-regulated virus genes (LMP1 and LMP2) and the EBNA2-independent EBER genes in the first 2 weeks. By 30 days post infection, LPKO transcription was the same as wild-type EBV. In contrast, EBNA2-regulated cellular genes were induced efficiently by LPKO viruses. Chromatin immunoprecipitation revealed that EBNA2 and the host transcription factors EBF1 and RBPJ were delayed in their recruitment to all viral latency promoters tested, whereas these same factors were recruited efficiently to several host genes, which exhibited increased EBNA2 recruitment. We conclude that EBNA-LP does not simply co-operate with EBNA2 in activating gene transcription, but rather facilitates the recruitment of several transcription factors to the viral genome, to enable transcription of virus latency genes. Additionally, our findings suggest that EBNA-LP is essential for the survival of EBV-infected naïve B cells.

  3. Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome

    Science.gov (United States)

    Szymula, Agnieszka; Palermo, Richard D.; Bayoumy, Amr; Groves, Ian J.

    2018-01-01

    The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vitro. We generated EBNA-LP knockout (LPKO) EBVs containing a STOP codon within each repeat unit of internal repeat 1 (IR1). EBNA-LP-mutant EBVs established lymphoblastoid cell lines (LCLs) from adult B cells at reduced efficiency, but not from umbilical cord B cells, which died approximately two weeks after infection. Adult B cells only established EBNA-LP-null LCLs with a memory (CD27+) phenotype. Quantitative PCR analysis of virus gene expression after infection identified both an altered ratio of the EBNA genes, and a dramatic reduction in transcript levels of both EBNA2-regulated virus genes (LMP1 and LMP2) and the EBNA2-independent EBER genes in the first 2 weeks. By 30 days post infection, LPKO transcription was the same as wild-type EBV. In contrast, EBNA2-regulated cellular genes were induced efficiently by LPKO viruses. Chromatin immunoprecipitation revealed that EBNA2 and the host transcription factors EBF1 and RBPJ were delayed in their recruitment to all viral latency promoters tested, whereas these same factors were recruited efficiently to several host genes, which exhibited increased EBNA2 recruitment. We conclude that EBNA-LP does not simply co-operate with EBNA2 in activating gene transcription, but rather facilitates the recruitment of several transcription factors to the viral genome, to enable transcription of virus latency genes. Additionally, our findings suggest that EBNA-LP is essential for the survival of EBV-infected naïve B cells. PMID:29462212

  4. 76 FR 41041 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Interaction of Systems...

    Science.gov (United States)

    2011-07-13

    ... Conditions No. 25-439-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Interaction... special conditions are issued for the Gulfstream Aerospace LP (GALP) Model G250 airplane. This airplane...

  5. The lysine-peptoid hybrid LP5 maintain activity under physiological conditions and affects virulence gene expression in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Gottschalk, Sanne; Ingmer, Hanne; Thomsen, Line E.

    2016-01-01

    The antimicrobial peptide, LP5, is a lysine-peptoid hybrid, with antimicrobial activity against clinically relevant bacteria. Here, we investigated how various environmental conditions affect the antimicrobial activity of LP5 against Staphylococcus aureus (S. aureus). We found that LP5 maintained...

  6. Statistical Review of Global LP Gas 2002

    International Nuclear Information System (INIS)

    2002-01-01

    This review provides essential production and consumption data from 1991 through 2001. A detailed breakdown of supply and sector demand is given for the year 2001 and historic data on international trade, shipping and pricing is also shown. Statistics pertaining to auto-gas are also included in this edition of Statistical Review of Global LP Gas 2001. (author)

  7. Statistical review of global LP gas 2001

    International Nuclear Information System (INIS)

    2001-01-01

    This review provides essential production and consumption data from 1990 through 2000. A more detailed breakdown of supply and sector demand is given for the year 2000 and historic data on international trade, shipping and pricing is also shown. Statistics pertaining to auto-gas are also included in this edition of Statistical Review of Global LP Gas 2001. (author)

  8. 75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2010-08-20

    ... Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Project No.: 7320-040. c. Dated Filed: June 29, 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e...: John Mudre at (202) 502-8902; or e-mail at [email protected] . j. Erie Boulevard Hydropower, L.P...

  9. A demographic dividend of the FP2020 Initiative and the SDG reproductive health target: Case studies of India and Nigeria.

    Science.gov (United States)

    Li, Qingfeng; Rimon, Jose G

    2018-02-22

    Background: The demographic dividend, defined as the economic growth potential resulting from favorable shifts in population age structure following rapid fertility decline, has been widely employed to advocate improving access to family planning. The current framework focuses on the long-term potential, while the short-term benefits may also help persuade policy makers to invest in family planning. Methods: We estimate the short- and medium-term economic benefits from two major family planning goals: the Family Planning 2020 (FP2020)'s goal of adding 120 million modern contraceptive users by 2020; Sustainable Development Goals (SDG) 3.7 of ensuring universal access to family planning by 2030. We apply the cohort component method to World Population Prospects and National Transfer Accounts data. India and Nigeria, respectively the most populous Asian and African country under the FP2020 initiative, are used as case studies. Results: Meeting the FP2020 target implies that on average, the number of children that need to be supported by every 100 working-age people would decrease by 8 persons in India and 11 persons in Nigeria in 2020; the associated reduction remains at 8 persons in India, but increases to 14 persons in Nigeria by 2030 under the SDG 3.7. In India meeting the FP2020 target would yield a saving of US$18.2 billion (PPP) in consumption expenditures for children and youth in the year 2020 alone, and that increased to US$89.7 billion by 2030. In Nigeria the consumption saved would be US$2.5 billion in 2020 and $12.9 billion by 2030. Conclusions: The tremendous economic benefits from meeting the FP2020 and SDG family planning targets demonstrate the cost-effectiveness of investment in promoting access to contraceptive methods. The gap already apparent between the observed and targeted trajectories indicates tremendous missing opportunities. Accelerated progress is needed to achieve the FP2020 and SDG goals and so reap the demographic dividend.

  10. Meningococcal serogroup B-specific responses after vaccination with bivalent rLP2086: 4 year follow-up of a randomised, single-blind, placebo-controlled, phase 2 trial.

    Science.gov (United States)

    Marshall, Helen S; Richmond, Peter C; Beeslaar, Johannes; Jiang, Qin; Jansen, Kathrin U; Garcés-Sánchez, Maria; Martinón-Torres, Federico; Szenborn, Leszek; Wysocki, Jacek; Eiden, Joseph; Harris, Shannon L; Jones, Thomas R; Lee, Su-San; Perez, John L

    2017-01-01

    Bivalent rLP2086 is a recombinant factor H binding protein-based vaccine approved in the USA for prevention of meningococcal serogroup B disease in 10-25-year-olds. We aimed to assess the persistence of bactericidal antibodies up to 4 years after a three-dose schedule of bivalent rLP2086. We did this randomised, single-blind, placebo-controlled, phase 2 trial at 25 sites in Australia, Poland, and Spain. In stage 1 of the study (February, 2009-May, 2010), healthy adolescents (aged 11-18 years) were randomly assigned, via an interactive voice and web-response system with computer-generated sequential random numbers, to receive either ascending doses of vaccine (60 μg, 120 μg, and 200 μg) or placebo at months 0, 2, and 6. Dispensing staff were not masked to group allocation, but allocation was concealed from principal investigators, participants and their guardians, and laboratory personnel. In stage 2 of the study (reported here), we enrolled healthy adolescents who had received three doses of 120 μg bivalent rLP2086 (the optimum dose level identified in stage 1) or saline. Immunogenicity was determined in serum bactericidal antibody assay using human complement (hSBA) by use of four meningococcal serogroup B test strains expressing vaccine-heterologous factor H binding protein variants: PMB80 (A22), PMB2001 (A56), PMB2948 (B24), and PMB2707 (B44). Immunogenicity in stage 2 was assessed at months 6, 12, 24, and 48 post-vaccination. We did analysis by intention to treat. This trial is registered as ClinicalTrials.gov number NCT00808028. Between March 17, 2010, and Feb 8, 2011, 170 participants who received 120 μg of bivalent rLP2086 and 80 participants who received placebo in stage 1 of the study were entered into stage 2; 210 participants completed stage 2 up to 48 months. 1 month after the third vaccination, 93% (n=139/149) to 100% (n=48/48) of vaccine recipients achieved protective hSBA titres equal to or greater than the lower limit of quantification to each

  11. Poly-(R)-3-hydroxybutyrates (PHB) are Atherogenic Components of Lipoprotein Lp(a).

    Science.gov (United States)

    Reusch, Rosetta N

    2015-12-01

    The hypothesis is that poly-(R)-3-hydroxybutyrates (PHB), linear polymers of the ketone body, R-3-hydroxybutyrate (R-3HB), are atherogenic components of lipoprotein Lp(a). PHB are universal constituents of biological cells and are thus components of all foods. Medium chain-length PHB (PHB (PHB are highly insoluble in water, but soluble in lipids in which they exhibit a high intrinsic viscosity. They have a higher density than other cellular lipids and they are very adhesive, i.e. they engage in multiple noncovalent interactions with other molecules and salts via hydrogen, hydrophobic and coordinate bonds, thus producing insoluble deposits. Following digestive processes, PHB enter the circulation in chylomicrons and very low density lipoproteins (VLDL). The majority of the PHB (>70%) are absorbed by albumin, which transports them to the liver for disposal. When the amount of PHB in the diet exceed the capacity of albumin to safely remove them from the circulation, the excess PHB remain in the lipid core of LDL particles that become constituents of lipoprotein Lp(a), and contribute to the formation of arterial deposits. In summary, the presence of PHB – water-insoluble, dense, viscous, adhesive polymers – in the lipid cores of the LDL moieties of Lp(a) particles supports the hypothesis that PHB are atherogenic components of Lp(a).

  12. Comparative Genomic Analysis of Lactobacillus plantarum GB-LP1 Isolated from Traditional Korean Fermented Food.

    Science.gov (United States)

    Yu, Jihyun; Ahn, Sojin; Kim, Kwondo; Caetano-Anolles, Kelsey; Lee, Chanho; Kang, Jungsun; Cho, Kyungjin; Yoon, Sook Hee; Kang, Dae-Kyung; Kim, Heebal

    2017-08-28

    As probiotics play an important role in maintaining a healthy gut flora environment through antitoxin activity and inhibition of pathogen colonization, they have been of interest to the medical research community for quite some time now. Probiotic bacteria such as Lactobacillus plantarum , which can be found in fermented food, are of particular interest given their easy accessibility. We performed whole-genome sequencing and genomic analysis on a GB-LP1 strain of L. plantarum isolated from Korean traditional fermented food; this strain is well known for its functions in immune response, suppression of pathogen growth, and antitoxin effects. The complete genome sequence of GB-LP1 is a single chromosome of 3,040,388 bp with 2,899 predicted open reading frames. Genomic analysis of GB-LP1 revealed two CRISPR regions and genes showing accelerated evolution, which may have antibiotic and antitoxin functions. The aim of the present study was to predict strain specific-genomic characteristics and assess the potential of this new strain as lactic acid bacteria at the genomic level using in silico analysis. These results provide insight into the L. plantarum species as well as confirm the possibility of its utility as a candidate probiotic.

  13. Univariate Lp and ɭ p Averaging, 0 < p < 1, in Polynomial Time by Utilization of Statistical Structure

    Directory of Open Access Journals (Sweden)

    John E. Lavery

    2012-10-01

    Full Text Available We present evidence that one can calculate generically combinatorially expensive Lp and lp averages, 0 < p < 1, in polynomial time by restricting the data to come from a wide class of statistical distributions. Our approach differs from the approaches in the previous literature, which are based on a priori sparsity requirements or on accepting a local minimum as a replacement for a global minimum. The functionals by which Lp averages are calculated are not convex but are radially monotonic and the functionals by which lp averages are calculated are nearly so, which are the keys to solvability in polynomial time. Analytical results for symmetric, radially monotonic univariate distributions are presented. An algorithm for univariate lp averaging is presented. Computational results for a Gaussian distribution, a class of symmetric heavy-tailed distributions and a class of asymmetric heavy-tailed distributions are presented. Many phenomena in human-based areas are increasingly known to be represented by data that have large numbers of outliers and belong to very heavy-tailed distributions. When tails of distributions are so heavy that even medians (L1 and l1 averages do not exist, one needs to consider using lp minimization principles with 0 < p < 1.

  14. Equalizer Complexity for 6-LP Mode 112 Gbit/s m-ary DP-QAM Space Division Multiplexed Transmission in Strongly Coupled Few-Mode-Fibers

    DEFF Research Database (Denmark)

    Asif, Rameez; Ye, Feihong; Morioka, Toshio

    2015-01-01

    12×12 multiple-input multiple-output (MIMO) adaptive digital signal processing (DSP). Time domain equalization (TDE) is realized to implement the linear adaptive MIMO module that is implemented in blind mode using conventional constant-modulusalgorithm (CMA) for finite impulse response (FIR) adaptive......We have quantified equalizer complexity for transmitting dual-polarized 6-LP modes (LP01, LP11a, LP11b, LP21a, LP21b and LP02) of 112 Gbit/s m-ary QAM (m=4, 16, 32, 64, 256) single carrier signals over 20 km step-index few-mode fiber. The transmitted signals are strongly coupled and recovered using...

  15. Transgender men's experiences of fertility preservation: a qualitative study.

    Science.gov (United States)

    Armuand, G; Dhejne, C; Olofsson, J I; Rodriguez-Wallberg, K A

    2017-02-01

    How do transgender men experience fertility preservation (FP) by cryopreservation of oocytes? The procedures required prior to oocyte cryopreservation, such as hormonal ovarian stimulation and transvaginal ultrasound (TVS), have a negative impact on gender dysphoria as they are closely linked to the men's female assigned sex at birth, which is incompatible with their current status. Transgender persons often have high dissatisfaction with assigned sex-specific body features, such as the genital organs and androgen/oestrogen-responsive features. Thus, undergoing FP that requires genital-specific examinations, aimed at obtaining oocytes to cryopreserve, could be distressing. As no previous studies have investigated transgender men's experiences of FP involving cryopreservation of oocytes, little is known about their experience of the procedures. This is a prospective study among adult transgender men referred for FP between March 2014 and December 2015. Individual in-depth qualitative interviews were conducted shortly after FP treatment. The interviews lasted between 62 and 111 min (mean 81 min) and were digitally recorded and transcribed verbatim. Participants were recruited on their first visit to the assisted reproduction clinic for reproductive counseling. There were 15 men, scheduled for FP, who chose to participate in the study (age 19-35); none had given birth and eight had a partner. Data were analyzed by thematic content analysis. The analysis resulted in three main categories: the journey to FP, reactions to the FP proceedings and strategies for coping. The referral for FP was an important part of the assessment and diagnosis and sometimes lined with frustrating waits and doubts. The reaction to the FP proceedings revealed that the genital examinations and the physical changes associated with discontinuation of testosterone or hormonal stimulation treatment triggered gender incongruence and dysphoria. However, for some, the negative expectations were not

  16. 76 FR 2432 - Bancshares Capital, L.P.; Notice of Surrender Under 13 CFR 107.1900

    Science.gov (United States)

    2011-01-13

    ... SMALL BUSINESS ADMINISTRATION [License No. 10/10-0194] Bancshares Capital, L.P.; Notice of Surrender Under 13 CFR 107.1900 Pursuant to the authority granted to the United States Small Business... 107.1900 of the Small Business Administration Rules and Regulations Bancshares Capital, L.P., 16118...

  17. 75 FR 35017 - Brookfield Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2010-06-21

    ... Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of Brookfield Energy Marketing LP's application for market-based rate authority, with an... protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To...

  18. Comparison of Lp(a) concentrations and some potential effects in hemodialysis, CAPD, transplantation, and control groups, and review of the literature.

    Science.gov (United States)

    Gault, M H; Longerich, L L; Purchase, L; Harnett, J; Breckenridge, C

    1995-01-01

    Apolipoprotein (a)-Lp(a)-is reported to be an independent risk factor for coronary artery disease and for hemodialysis (HD) access occlusion. Homology with plasminogen may predispose to thrombosis. High concentrations usually have been reported in patients on HD and on continuous ambulatory peritoneal dialysis (CAPD), but near-normal values in many kidney transplants (TP). We used Pharmacia immunoradiometric assay in 52 patients on HD, 58 on CAPD, 94 after TP, and 56 controls. The Lp(a) mean levels for CAPD, HD, TP, and control groups were 738, 647, 348, and 368 U/l and the medians were 542, 537, 96 and 143 U/l, respectively. The means and medians for CAPD and HD were significantly greater than those for TP and controls (p fall 77%). The dominant Apo(a) isoform in 10 of 13 patients on CAPD or HD with high Lp(a) values was the equivalent of S2 (Utermann). Lp(a) in HD or CAPD is often elevated and regulated by both genetic and renal failure factors, but falls after TP with return of renal function and mainly genetic regulation. Lp(a) was not a risk factor for coronary artery disease in HD or CAPD patients and did not fall significantly with two drugs or diet.

  19. Improvement and Validation of an Aerosol Deposition Model in the GAMMA-FP, a Fission Product Analysis Module for VHTRs

    International Nuclear Information System (INIS)

    Yoon, Churl; Lim, Hong Sik

    2013-01-01

    GAMMA-FP (GAs Multicomponent Mixture Analysis-Fission Products module), consists of gaseous and aerosol fission product analysis modules. The aerosol FP module adopts a multi-component and multi-sectional aerosol analysis model that has been developed based on the MAEROS model. For the first work of FP module development, the MAEROS model has been implemented and examined against some analytic solutions and experimental data by Yoo et al. An aerosol transport model was developed and implemented in the GAMMA-FP code, and verified. In this study, the aerosol deposition model in the GAMMA-FP code was improved by adopting recent achievements, and was validated against an experimental data available. The aerosol deposition model in the GAMMA-FP code has been improved and successfully validated against the STORM SR-11 deposition test. The simulation with the improved deposition model predicted the matched results with the experimental data well. For future studies, the aerosol deposition model by flow irregularities will be implemented and validated against the TRANSAT bend effect test

  20. Improvement and Validation of an Aerosol Deposition Model in the GAMMA-FP, a Fission Product Analysis Module for VHTRs

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Churl; Lim, Hong Sik [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    GAMMA-FP (GAs Multicomponent Mixture Analysis-Fission Products module), consists of gaseous and aerosol fission product analysis modules. The aerosol FP module adopts a multi-component and multi-sectional aerosol analysis model that has been developed based on the MAEROS model. For the first work of FP module development, the MAEROS model has been implemented and examined against some analytic solutions and experimental data by Yoo et al. An aerosol transport model was developed and implemented in the GAMMA-FP code, and verified. In this study, the aerosol deposition model in the GAMMA-FP code was improved by adopting recent achievements, and was validated against an experimental data available. The aerosol deposition model in the GAMMA-FP code has been improved and successfully validated against the STORM SR-11 deposition test. The simulation with the improved deposition model predicted the matched results with the experimental data well. For future studies, the aerosol deposition model by flow irregularities will be implemented and validated against the TRANSAT bend effect test.

  1. Increased intra-abdominal fat may lower HDL levels by increasing the fractional catabolic rate of Lp A-I in postmenopausal women.

    Science.gov (United States)

    Vajo, Zoltan; Terry, James G; Brinton, Eliot A

    2002-02-01

    High-density lipoprotein (HDL) particles without apolipoprotein A-II (Lp A-I) may be more anti-atherogenic than HDL with apo A-II (Lp A-I/AII) and Lp A-I is reported selectively to be reduced in cases of intra-abdominal obesity. We explored the mechanisms of this reduction by studying the turnover of Lp A-I and Lp A-I/A-II in postmenopausal women well characterized for total body, regional and sub-regional adiposity by body mass index (BMI), truncal girth ratio, and abdominal magnetic resonance imaging (MRI), respectively. We tested for possible cause-effect relationships by measuring inter-correlations among these variables. Intra-abdominal fat area correlated strongly and positively with the fractional catabolic rate (FCR) of Lp A-I (r=0.98, P=0.003). Intra-abdominal fat only showed a non-significant trend toward correlation with the FCR of Lp A-I/A-II (r=0.84, P=0.07), and had no correlation with the production or transport rate (TR) of either Lp A-I or Lp A-I/A-II (r=0.48 and 0.02, respectively, P>0.1). Subjects were studied both with and without estrogen replacement, allowing exploration of a possible interaction of adiposity with estrogen effects on HDL turnover. Response of HDL turnover to estrogen did not correlate with adiposity, except for a parameter of waist to hip ratio (WHR), which predicted the increase in LP A-I TR with estrogen (r=0.84, P=0.04). We conclude that intra-abdominal fat may lower HDL levels by increasing the FCR of Lp A-I, suggesting a mechanism by which central adiposity may be proatherogenic.

  2. Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v.

    Science.gov (United States)

    Jones, Claire; Badger, Stephen A; Regan, Mark; Clements, Barry W; Diamond, Tom; Parks, Rowan W; Taylor, Mark A

    2013-12-01

    This study aimed to determine the effect of LP229v on intestinal permeability and tumour necrosis factor (TNF) p55 receptor concentrations in patients with obstructive jaundice undergoing biliary drainage. Patients undergoing biliary drainage were recruited and randomized into three groups to receive Lactobacillus plantarum 299v (LP299v), inactivated LP299v (placebo) or water. These were administered daily at noon until 7 days after biliary drainage. Intestinal permeability was measured using the lactulose/mannitol (L/M) dual sugar absorption test on admission, the day before biliary drainage and on days 1 and 7 after biliary drainage. Blood and urine were collected to determine the L/M ratio and the TNF p55 receptor levels at each time point. A total of 25 patients were recruited; 12 had choledocholithiasis and nine had a periampullary tumour. Open surgical biliary drainage was performed in nine patients, endoscopic retrograde cholangiopancreatography in 12 and percutaneous transhepatic cholangiography in two. Five patients received LP299v, five received placebo and seven, water. The median L/M ratio was 0.035 (0.018-0.065) at baseline. No difference existed between the groups on admission, before drainage and on day 7 after drainage (P=0.59, 0.175 and 0.61, respectively). The L/M ratio was lower in the LP299v group on day 1 after drainage [0.01 (0.01) vs. 0.18 (0.03-0.3) and 0.11 (0.07-0.14); P=0.37]. Although the TNF p55 receptor levels were lower on day 1 after drainage in the LP299v group (15.3 vs. 30.9 vs. 82.7 ng/ml; P=0.43), the concentration at the four time points was similar (P=0.24, 0.96, 0.43 and 0.68). Pretreatment with probiotic LP299v improves intestinal permeability after biliary drainage and attenuates the inflammatory response. However, a larger multicentre trial is required to determine the effect on clinical outcome.

  3. Who's who in the LP-Gas industry

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    All pertinent information about the most important North American companies in the LP-Gas industry are listed alphabetically in an easy-to-use directory. A total of 395 listings are included. Besides company names and addresses, other information such as key personnel and products produced and marketed to affiliated companies, and a list of other services offered by each company are also provided

  4. Dødshjælp, drabsforbud og deontologi

    DEFF Research Database (Denmark)

    Dige, Morten

    2008-01-01

    Et velkendt argument imod aktiv dødshjælp har det deontologiske forbud mod drab eller pligten til ikke at slå ihjel som en central præmis. Sådanne deontologiske argumenter spiller en fremtrædende rolle i nylige publikationer fra Det Etiske Råd. For at gælde ukvalificeret, må disse argumenter imid...

  5. 76 FR 12103 - Erie Boulevard Hydropower, L.P; Notice of Settlement Agreement and Soliciting Comments

    Science.gov (United States)

    2011-03-04

    ... Hydropower, L.P; Notice of Settlement Agreement and Soliciting Comments Take notice that the following... Boulevard Hydropower, L.P. e. Location: The existing multi-development project is located on the Oswegatchie... 791 (a)-825(r) h. Applicant Contact: Daniel Daoust, Erie Boulevard Hydropower, 33 West 1st Street...

  6. Morphological and morphometric evaluation of prepubertal gilt ovaries, uterine tubes and uterus at different oestrus cycle stages

    Directory of Open Access Journals (Sweden)

    Guilherme Oberlender

    2014-01-01

    Full Text Available Studies are performed in developing techniques/procedures that provide greater reproductive performance in farm animals, including pigs. In this sense, the study of gilts reproductive organs at different oestrus cycle stages for assessing the presence of abnormalities and/or other parameters that may affect the future animal fertility is important. In order to evaluate the morphological, morphometric and histomorphometric features of ovaries, uterus and uterine tubes (UTs characteristics of prepubertal gilts at different oestrus cycle stages, reproductive tracts from 48 animals immediately after slaughter were obtained. After, the structures were dissected and removed, and the ovaries were used for classification of oestrus cycle stage of each gilt in follicular phase (FP and luteal phase (FL. Then, morphometric evaluations of ovaries, UTs, uterine horns and uterine body were performed. Besides that, medial segments of UTs and uterus were fixed in Bouin solution, processed and included in paraffin, when histological sections of 5.0 micrometers (µm were obtained and stained with Hematoxylin and Eosin. Histomorphometric analyzes using image capture system and specific software were performed. Afterwards, data were submitted to Student's t test for assessment the statistical differences (P0.05 between morphometric parameters of ovaries, UTs and uterus of gilts in FP and LP. Likewise, in respect to the placement of reproductive structures, both in the oestrus cycle stages, as in the general average, there was no difference (P>0.05. Regarding the histomorphometric variables, gilts classified in FP presented a higher (P<0.05 height of glandular and UT epithelium compared to animals in LP. On the other hand, the diameter of endometrial glands was higher (P<0.05 in gilts at LP compared to FP. Furthermore, gilts in LP presented a higher (P<0.05 proportion of endometrium occupied by glands, whereas animals in FP had a higher (P<0.05 proportion of

  7. Bivalent rLP2086 Vaccine (Trumenba(®)): A Review in Active Immunization Against Invasive Meningococcal Group B Disease in Individuals Aged 10-25 Years.

    Science.gov (United States)

    Shirley, Matt; Dhillon, Sohita

    2015-10-01

    Bivalent rLP2086 vaccine (Trumenba(®)) [hereafter referred to as rLP2086] is a Neisseria meningitidis serogroup B (MenB) vaccine recently licensed in the USA for active immunization to prevent invasive disease caused by MenB in individuals 10-25 years of age. rLP2086, which contains two variants of the meningococcal surface protein factor H-binding protein (fHBP), was approved by the FDA under the accelerated approval pathway after the immunogenicity of the vaccine was demonstrated in several phase II trials. This article reviews the immunogenicity and reactogenicity of rLP2086 as demonstrated in the trials with a focus on the US setting and on use of the vaccine as per FDA-approved labeling. rLP2086 is approved in the USA as a three-dose series administered in a 0-, 2-, and 6-month schedule. In the phase II trials, rLP2086 elicited a robust immune response against a panel of MenB test strains. A strong immune response was evident in a marked proportion of subjects after two vaccine doses, with a further increase after a third dose. The four primary test strains used were selected to be representative of MenB strains prevalent in the USA, with each expressing an fHBP variant heterologous to the vaccine antigens. rLP2086 was generally well tolerated in the trials, with most adverse reactions being mild to moderate in severity. Although some questions remain, including the duration of the protective response, rLP2086 vaccine has the potential to be a valuable tool for the prevention of invasive MenB disease.

  8. Determination of tea fluorine concentration with 19F(p, αγ)16O prompt nuclear reaction analysis

    International Nuclear Information System (INIS)

    Liang Daihua; Shen Guantao; Li Deyi; Wu Junheng

    1987-01-01

    Experiments of 19 F(p, αγ) 16 O prompt nuclear reaction analyses of tea F contents were performed on a Cockroft-Walton accelerator. The principle and apparatus are described. More than 150 varieties tea samples were examined. Results show that for the same variety of tea samples, the higher the grade of the tea, the higher the F concentration it contains, and for different varieties, the better the tea, the lower the F concentration of the tea

  9. Clinical features and 123I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson's disease

    International Nuclear Information System (INIS)

    Diaz-Corrales, Francisco J.; Escobar-Delgado, Teresa; Sanz-Viedma, Salome; Garcia-Solis, David; Mir, Pablo

    2010-01-01

    To determine clinical predictors and accuracy of 123 I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson's disease (PD). Several clinical features and 123 I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (PDu) and 22 patients with PD without a previous history of antidopaminergic treatment (PDc) were retrospectively evaluated. DIP and PD shared all clinical features except symmetry of parkinsonian signs which was more frequently observed in patients with DIP (46.9%) than in patients with PDu (16.0%, p 123 I-FP-CIT SPECT images were normal in 29 patients with DIP (90.6%) and abnormal in all patients with PD, and this imaging technique showed high levels of accuracy. DIP and PD are difficult to differentiate based on clinical signs. The precision of clinical diagnosis could be reliably enhanced by 123 I-FP-CIT SPECT imaging. (orig.)

  10. PELATIHAN MOULD LOFT (LANTAI GAMBAR KAPAL BAGI PENGRAJIN/PEMBUAT KAPAL TRADISIONAL DI KABUPATEN BATANG - JAWA TENGAH

    Directory of Open Access Journals (Sweden)

    Parlindungan Manik

    2015-08-01

    Full Text Available Kabupaten Batang yang merupakan wilayah pesisir mempunyai banyak potensi yang dapat dikembangkan menjadi aset yang berharga bagi bangsa yaitu para pengrajin/pembuat kapal tradisional. Para pengrajin ini mampu menghasilkan kapal tipe mini purse seine yang mampu berlayar dalam radius pelayaran 12 sampai dengan 200 mil laut. Kapal mini purse siene tipe Batang mempunyai karakteristik yang cukup baik karena mempunyai stabilitas kapal yang baik dan mesin utama diletakkan di dalam kamar mesin (inboard engine. Kapal purse seine ini telah dibuat dan diproduksi secara turun-temurun dan jumlahnya sudah banyak di daerah Batang. Ukuran kapal yang diproduksi mulai dari 5 GT (Gross Tonage sampai dengan 40 GT dengan harga sebesar 300 juta sampai dengan 2 miliar rupiah. Para pembuat kapal pada umumnya tidak atau kurang memiliki pengetahuan tentang gambar desain kapal dari kapal yang diproduksi. Belakangan ini telah dimulai oleh para pengguna yang mensyaratkan adanya gambar desain dan gambar – gambar kerja lainnya sehingga dituntut adanya tenaga kerja dan para pembuat kapal yang mampu membuat dan membaca gambar kapal. Pada Program IbM ini dilaksanakan di CV. Laksana Abadi dan dan CV. Rizki Maulana Bahari yang bertujuan agar para pengrajin/pembuat kapal kayu tradisional di kabupaten Batang memiliki ketrampilan untuk menggambar bentuk badan kapal dalam skala 1:1 pada lantai gambar atau biasa disebut dengan istilah Mould Loft. Dengan tergambarnya bentuk badan kapal/konstruksi kapal dalam skala 1:1 maka akan didapat bentuk badan kapal yang akurat dan ukuran konstruksi kapal yang tepat, sehingga dalam proses pembangunannya segala ukuran yang terpakai sudah tepat dan tidak ada kesalahan bentuk maupun ukuran. Hal ini sangat diperlukan oleh pihak pelaksana, untuk menunjang kemudahan pelaksanaan dan kualitas hasil pekerjaan. Pendekatan yang diterapkan dalam penerapan teknologi ini harus mencakup dua buah aspek yaitu : aspek kognitif dan psikomotorik. Pada aspek kognitif

  11. Supply chain management using fp-growth algorithm for medicine distribution

    Science.gov (United States)

    Wahana, A.; Maylawati, D. S.; Irfan, M.; Effendy, H.

    2018-03-01

    Distribution of drugs evenly in accordance with the needs of Public Health Center (Puskesmas) become one of the responsibilities by the Health Office in Indonesia. This study aims to provide recommendations for distribution of drugs from the Department of Health according to the needs of each Puskesmas. Because often the distribution of drugs is not in accordance with the needs of medicines stock of each Puskesmas. This causes the possibility of drug stock void in Puskesmas in need, while there is excess stock of drugs in Puskesmas that do not need. Supply Chain Management (SCM) is applied as a controlling drug stock at Puskesmas in order to avoid drug vacuum or excess drug that eventually unused. In addition, the Frequent Pattern Growth (FP-Growth) algorithm that generates frequent item sets is used to provide drug distribution recommendations by looking at the highest frequency of drug occurrences and frequent drug frequencies. Based on testing black box system conducted in Health Office Purwakarta regency of Indonesia which oversees 20 Puskesmas with 100 data of drug distribution transactions, it can be concluded that system functionality is running well and SCM successfully implemented to arrange distribution process of medicine well. Furthermore FP-Growth algorithm was able to provide recommendations for distribution of drugs with a high success rate. This is evidenced by the test results with various combinations of input parameters, FP-Growth is able to produce the right frequent item sets.

  12. Increased risk of coronary artery calcification progression in subjects with high baseline Lp(a) levels: The Kangbuk Samsung Health Study.

    Science.gov (United States)

    Cho, Jung Hwan; Lee, Da Young; Lee, Eun Seo; Kim, Jihyun; Park, Se Eun; Park, Cheol-Young; Lee, Won-Young; Oh, Ki-Won; Park, Sung-Woo; Rhee, Eun-Jung

    2016-11-01

    Results from previous studies support the association of lipoprotein(a) [Lp(a)] levels and coronary artery disease risk. In this study, we analyzed the association between baseline Lp(a) levels and future progression of coronary artery calcification (CAC) in apparently healthy Korean adults. A total of 2611 participants (mean age: 41years, 92% mend) who underwent a routine health check-up in 2010 and 2014 were enrolled. Coronary artery calcium score (CACS) were measured by multi-detector computed tomography. Baseline Lp(a) was measured by high-sensitivity immunoturbidimetric assay. Progression of CAC was defined as a change in CACS >0 over four years. Bivariate correlation analyses with baseline Lp(a) and other metabolic parameters revealed age, total cholesterol, HDL-C, LDL-C and CACS to have a significant positive correlation, while body weight, fasting glucose level, blood pressure and triglyceride level were negatively correlated with baseline Lp(a) level. After four years of follow-up, 635 subjects (24.3%) had CAC progression. The participants who had CAC progression were older, composed of more men, more obese, and had higher fasting glucose levels and worse baseline lipid profiles compared to those who did not have CAC progression. The mean serum Lp(a) level was significantly higher in subjects who had CAC progression compared to those who did not (32.5 vs. 28.9mg/dL, p<0.01). When the risk for CAC progression according to baseline Lp(a) was calculated, those with Lp(a) level≥50mg/dL had an odds ratio of 1.333 (95% CI 1.027-1.730) for CAC progression compared to those with Lp(a)<50mg/dL after adjusting for confounding factors. In this study, the subjects who had higher Lp(a) were at significantly higher risk for CAC progression after four years of follow-up, suggesting the role of high Lp(a) in CAC progression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  13. 77 FR 71585 - Brookfield Energy Marketing LP v. ISO New England Inc.; Notice of Complaint

    Science.gov (United States)

    2012-12-03

    ... Energy Marketing LP v. ISO New England Inc.; Notice of Complaint Take notice that on November 21, 2012...), Brookfield Energy Marketing LP (Complainant) filed a formal complaint against ISO New England Inc... notification when a document is added to a subscribed docket(s). For assistance with any FERC Online service...

  14. 76 FR 45247 - Tesoro Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint

    Science.gov (United States)

    2011-07-28

    ... Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint Take notice that on July 20, 2011... Marketing Company (Complainant) filed a formal complaint against SFPP L.P. (SFPP or Respondent) alleging... with any FERC Online service, please e-mail [email protected] , or call (866) 208-3676 (toll...

  15. Sunoco Pipeline, L.P. Clean Water Act Settlement - 2017

    Science.gov (United States)

    EPA, and the U.S. Department of Justice announced that Sunoco Pipeline, L.P. (Sunoco) has agreed to pay a civil penalty for alleged violation of the Clean Water Act stemming from a 2012 gasoline discharge near Wellington, Ohio.

  16. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers

    International Nuclear Information System (INIS)

    Lavalaye, J.; Booij, J.; Reneman, L.; Habraken, J.B.A.; Royen, E.A. van

    2000-01-01

    Dopamine transporter imaging is a valuable tool to investigate the integrity of the dopaminergic neurons. To date, several reports have shown an age-associated decline in dopamine transporters in healthy volunteers. Although animal studies suggest an effect of gender on dopamine transporter density, this gender effect has not yet been confirmed in human studies. To study the influence of age and gender on dopamine transporter imaging in healthy volunteers, we performed single-photon emission tomography imaging with [ 123 I]FP-CIT to quantify dopamine transporters. Forty-five healthy volunteers (23 males and 22 females) were included, ranging in age from 18 to 83 years. SPET imaging was performed 3 h after injection of ±110 MBq [ 123 I]FP-CIT. An operator-independent volume of interest analysis was used for quantification of [ 123 I]FP-CIT binding in the striatum. The ratio of specific striatal to non-specific [ 123 I]FP-CIT binding was found to decrease significantly with age. Moreover, we found a high variance in [ 123 I]FP-CIT binding in young adults. Finally, females were found to have significantly higher [ 123 I]FP-CIT binding ratios than males. This effect of gender on [ 123 I]FP-CIT binding ratios was not related to age. The results of this study are consistent with findings from previous studies, which showed that dopamine transporter density declines with age. The intriguing finding of a higher dopamine transporter density in females than in males is in line with findings from animal studies. (orig.)

  17. Fracture mechanics evaluation of LOFT lower plenum injection nozzle

    International Nuclear Information System (INIS)

    Nagata, P.K.; Reuter, W.G.

    1977-01-01

    An analysis to establish whether or not a leak-before-break concept would apply to the LOFT lower plenum injection nozzle is described. The analysis encompassed the structure from the inlet side of valve V-2170 to the lower plenum nozzle-to-reactor vessel weld on the left side of the emergency core cooling system (ECCS). The defect that was assumed to exist was of such a size that the probability of its being missed by the applicable inspection technique was near zero. The Inconel 600 nozzle forging with an initial assumed defect size of 0.64 cm (0.25 in.) deep would behave as follows: (1) the axially oriented defect would result in leak before rupture (the number of cycles to rupture was 11,000), (2) the circumferentially oriented defect would result in a rupture before leak. The number of cycles to failure would be in excess of 14,000. Based on the conservative assumption that the thermal stresses were membrane stresses as opposed to a bending stress, the following were found. For the Inconel 82 weld metal (thickness of 1.3 cm [0.53 in.]) and AISI 316 SST valve body, with an initial assumed defect of 0.25 cm (0.1 in.), the crack would grow through the thickness in a minimum of 3950 cycles and to a critical rupture crack length of 5.1 cm (2.0 in.) in an additional 80 cycles. The Inconel 82 weld metal at the shell body (thickness of 9.7 cm or 3.8 in.) with an assumed defect 1.3 cm (0.5 in.) deep would fail in 334 cycles. Calculations made assuming a linear stress gradient instead of the above-mentioned flat distribution through the wall indicated that the number of stress cycles increased to 2200

  18. Evaluating a LARC Expansion Program in 14 Sub-Saharan African Countries: A Service Delivery Model for Meeting FP2020 Goals.

    Science.gov (United States)

    Ngo, Thoai D; Nuccio, Olivia; Pereira, Shreya K; Footman, Katharine; Reiss, Kate

    2017-09-01

    Objectives In many sub-Saharan African countries, the use of long-acting reversible contraceptives (LARCs) is low while unmet need for family planning (FP) remains high. We evaluated the effectiveness of a LARC access expansion initiative in reaching young, less educated, poor, and rural women. Methods Starting in 2008, Marie Stopes International (MSI) has implemented a cross-country expansion intervention to increase access to LARCs through static clinics, mobile outreach units, and social franchising of private sector providers. We analyzed routine service statistics for 2008-2014 and 2014 client exit interview data. Indicators of effectiveness were the number of LARCs provided and the percentages of LARC clients who had not used a modern contraceptive in the last 3 months ("adopters"); switched from a short-term contraceptive to a LARC ("switchers"); were aged <25; lived in extreme poverty; had not completed primary school; lived in rural areas; and reported satisfaction with their overall experience at the facility/site. Results Our annual LARC service distribution increased 1037 % (from 149,881 to over 1.7 million) over 2008-2014. Of 3816 LARC clients interviewed, 46 % were adopters and 46 % switchers; 37 % were aged 15-24, 42 % had not completed primary education, and 56 % lived in a rural location. Satisfaction with services received was rated 4.46 out of 5. Conclusions The effectiveness of the LARC expansion in these 14 sub-Saharan African FP programs demonstrates vast untapped potential for wider use of LARC methods, and suggests that this service delivery model is a plausible way to support FP 2020 goals of reaching those with an unmet need for FP.

  19. 76 FR 45246 - Tesoro Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint

    Science.gov (United States)

    2011-07-28

    ... and Marketing Company v. SFPP, L.P.; Notice of Complaint Take notice that on July 20, 2011, pursuant...), Tesoro Refining and Marketing Company (Tesoro) filed a formal complaint against SFPP, L.P. (SFPP). Tesoro... notification when a document is added to a subscribed docket(s). For assistance with any FERC Online service...

  20. 77 FR 28375 - Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval

    Science.gov (United States)

    2012-05-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-25-000] Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval Take notice that on May 1, 2012, Eagle Rock Desoto Pipeline, L.P. (Desoto) filed a Rate Election pursuant to 284.123(b)(1) of the Commissions...

  1. Capability of LOFT vital batteries to supply emergency power demands during severe cold weather conditions

    International Nuclear Information System (INIS)

    Yeates, J.A.

    1978-01-01

    This study evaluates the capability of the vital batteries (PPS) to provide electrical power via the vital DC-AC motor generator sets to the LOFT PPS loads during severe cold weather conditions. It is concluded that these batteries while at a temperature of 5 0 F will supply the necessary PPS electrical loads for a time in excess of the one hour permitted to start the diesel generators and are, therefore, adequate at this temperature. This Revision B of the LTR includes revised, more recent, and complete technical data relating to MG set efficiency, battery operating procedures and cold temperature derating. Revision B supersedes and replaces all previous issues

  2. Developing the "120 by 20" goal for the Global FP2020 Initiative.

    Science.gov (United States)

    Brown, Win; Druce, Nel; Bunting, Julia; Radloff, Scott; Koroma, Desmond; Gupta, Srishti; Siems, Brian; Kerrigan, Monica; Kress, Dan; Darmstadt, Gary L

    2014-03-01

    This report describes the purpose for developing a quantitative goal for the London Summit on Family Planning held in July 2012, the methodology behind its formulation, and the lessons learned in the process. The London Summit has evolved into the global initiative known as FP2020, and the goal has become "120 by 20," or reaching 120 million additional users of modern contraceptive methods by 2020 in the world's poorest countries. The success of FP2020 will first be evaluated on the basis of quantitative verification to determine that the "120 by 20" goal was reached. More important, however, is the extent to which the goal today serves as a global rallying cry to mobilize resources and leadership around current family planning programs, with a focus on voluntary family planning and quality of care, and with an emphasis on meeting girls' and women's unmet needs and their right to practice contraception. We hope this article provides greater transparency and understanding of the FP2020 goal, and that the global goal spurs annual monitoring of progress toward national goals in the world's poorest countries. © 2014 The Population Council, Inc.

  3. State of the Art in LP-WAN Solutions for Industrial IoT Services

    OpenAIRE

    Sanchez-Iborra, Ramon; Cano, Maria-Dolores

    2016-01-01

    The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN), is explored. By means of a cellular-type architecture, LP-WAN–base...

  4. The Effects of Curcuma longa L., Purple Sweet Potato, and Mixtures of the Two on Immunomodulation in C57BL/6J Mice Infected with LP-BM5 Murine Leukemia Retrovirus.

    Science.gov (United States)

    Park, Soo-Jeung; Lee, Dasom; Lee, Minhee; Kwon, Han-Ol; Kim, Hyesook; Park, Jeongjin; Jeon, Woojin; Cha, Minseok; Jun, Suhwa; Park, Kwangjin; Lee, Jeongmin

    2018-06-04

    The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leukemia virus (MuLV). Mice were divided into seven groups as follows: normal control, infected control (LP-BM5 MuLV infection), positive control (LP-BM5 MuLV infection+dietary supplement of red ginseng 300 mg/kg body weight), the original powder of C. longa L. (C; LP-BM5 MuLV infection+dietary supplement of C 189 mg/kg body weight), the original powder of purple sweet potato (P; LP-BM5 MuLV infection+dietary supplement of P 1811 mg/kg body weight), CPM Low (CPL; LP-BM5 MuLV infection+CPM 2 g/kg body weight), and CPM High (CPH; LP-BM5 MuLV infection+CPM 5 g/kg body weight). Dietary supplementation lasted for 12 weeks. Dietary supplementation of CPM inhibited LP-BM5 MuLV-induced lymphadenopathy and splenomegaly and inhibited reduction of messenger RNA (mRNA) expression of major histocompatibility complex (MHC) I and II. Moreover, CPM reduced the decrease in T- and B cell proliferation, reduced the population of CD4(+)/CD8(+) T cells, and remedied the unbalanced production of T helper-1 (Th1)/T helper-2 (Th2) cytokines in LP-BM5 MuLV-infected mice. In addition, CPM inhibited reduction of phagocytosis in peritoneal macrophages and decreased serum levels of immunoglobulin A (IgA), immunoglobulin E (IgE), and immunoglobulin G (IgG). These results suggest that CPM had a positive effect on immunomodulation in C57BL/6 mice induced by LP-BM5 leukemia retrovirus infection.

  5. Benchmark on hydrogen distribution in a containment based on the OECD-NEA THAI HM-2 experiment

    International Nuclear Information System (INIS)

    Schwarz, S.; Fischer, K.; Bentaib, A.

    2009-01-01

    Within the course of a hypothetical severe accident in a nuclear power plant, hydrogen can be generated in the primary circuit and released into the containment. Considering the possibility of a deflagration, the simulation of the hydrogen distribution in the containment by computer codes is of major importance. In order to create a data base for code validation, several distribution experiments using helium and hydrogen have been performed in the German THAI (Thermal-Hydraulics, Hydrogen, Aerosols, Iodine) facility. They started with the ISP-47 test TH13 and were followed by the HM (Hydrogen-Helium Material Scaling Tests) series. The objectives of the HM Tests are to confirm the transferability of existing helium distribution test data to hydrogen distribution problems, to understand the processes that lead to the formation and dissolution of a light cloud stratification. The test HM-2 was chosen for a code benchmark. During the first phase of test HM-2 a light gas cloud consisting of hydrogen and nitrogen was established in the upper half of the facility. In the second phase steam was injected at a lower position inducing a rising steam - nitrogen plume. The plume did not break through the cloud, because its density was higher than the density of the cloud. Therefore the cloud was gradually dissolved from its bottom. Eleven organisations performed 'blind' calculations to the HM-2 experiment. The lumped parameter (LP) codes ASTEC, COCOSYS and MELCOR and the CFD codes FLUENT, GASFLOW and GOTHIC were used. The main phenomena were natural convection, interaction between the rising plume and the light gas cloud, steam condensation on walls, fog behaviour and the heat up of the walls. The experimental data of the first phase had been published and the atmospheric stratification was simulated reasonably well. The data from the second phase stayed concealed until the simulated results were submitted. The thermal-hydraulic phenomena were predicted well by several LP- and

  6. High spin structure of 35Cl and the sd-fp shell gap

    International Nuclear Information System (INIS)

    Kshetri, Ritesh; Saha Sarkar, M.; Ray, Indrani; Banerjee, P.; Sarkar, S.; Raut, Rajarshi; Goswami, A.; Chatterjee, J.M.; Chattopadhyay, S.; Datta Pramanik, U.; Mukherjee, A.; Dey, C.C.; Bhattacharya, S.; Dasmahapatra, B.; Bhowal, Samit; Gangopadhyay, G.; Datta, P.; Jain, H.C.; Bhowmik, R.K.; Muralithar, S.; Singh, R.P.; Kumar, R.

    2007-01-01

    The high spin states of 35 Cl have been studied by in-beam γ-spectroscopy following the fusion-evaporation reaction 12 C( 28 Si,αp) 35 Cl at E lab =70 and 88 MeV, using the Indian National Gamma (Clover) Array (INGA). Lifetimes of six new excited states have been estimated for the first time. To understand the underlying structure of the levels and transition mechanisms, experimental results have been compared with those from the large basis cross-shell shell model calculations. Involvement of orbitals from fp shell and squeezing of the sd-fp shell gap seem to be essential for reliable reproduction of high spin states

  7. 78 FR 48205 - Ranger Alternative Management, L.P. and Ranger Funds Investment Trust; Notice of Application

    Science.gov (United States)

    2013-08-07

    ... Alternative Management, L.P. and Ranger Funds Investment Trust; Notice of Application August 1, 2013. AGENCY... Management, L.P. (``Ranger'') and Ranger Funds Investment Trust (the ``Trust''). Summary of Application... (e) certain registered management investment companies and unit investment trusts outside of the same...

  8. 76 FR 66710 - Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing, Soliciting Comments...

    Science.gov (United States)

    2011-10-27

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 5984-063] Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing, Soliciting Comments, Motions To Intervene, and....: 5984-063. c. Date Filed: May 10, 2011. d. Applicant: Erie Boulevard Hydropower, L.P. (dba Brookfield...

  9. Direct comparison of FP-CIT SPECT and F-DOPA PET in patients with Parkinson's disease and healthy controls

    International Nuclear Information System (INIS)

    Eshuis, S.A.; Maguire, R.P.; Leenders, K.L.; Jager, P.L.; Jonkman, S.; Dierckx, R.A.

    2009-01-01

    Diagnosing Parkinson's disease (PD) on clinical grounds may be difficult, especially in the early stages of the disease. F-DOPA PET and FP-CIT SPECT scans are able to determine presynaptic dopaminergic activity in different ways. The aim of this study was to determine and compare the sensitivity and specificity of the two methods in the detection of striatal dopaminergic deficits in the same cohort of PD patients and healthy controls. Movement disorder specialists recruited 11 patients with early-stage PD and 17 patients with advanced PD. The patients underwent both an FP-CIT SPECT scan and an F-DOPA PET scan. In addition, 10 FP-CIT SPECT scans or 10 F-DOPA PET scans were performed in 20 healthy controls. A template with regions of interest was used to sample tracer activity of the caudate, putamen and a reference region in the brain. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were determined in the controls. The sensitivity and specificity of both scanning methods were calculated. FP-CIT SPECT and F-DOPA PET scans were both able to discriminate PD patients from healthy controls. For the early phases of the disease, sensitivity and specificity of the contralateral striatal and putaminal uptake of FP-CIT and F-DOPA was 100%. When only caudate uptake was considered, the specificities were 100% and 90% for FP-CIT and F-DOPA, respectively, while the sensitivity was 91% for both scanning techniques. FP-CIT SPECT and F-DOPA PET scans are both able to diagnose presynaptic dopaminergic deficits in early phases of PD with excellent sensitivity and specificity. (orig.)

  10. The role of boric acid in the Phebus-FP tests

    International Nuclear Information System (INIS)

    Bowsher, B.R.

    1991-12-01

    The data in this report should enable proposed methods for the introduction of boric acid into the Phebus-FP tests to be assessed. Boric acid chemistry is reviewed in the condensed, vapour and aqueous phases. The chemistry of concentrated aqueous solutions of boric acid is complex, involving polyborate species resulting in enhanced acidities. Equations are presented that allow the partition of boric acid between the vapour and aqueous phase to be calculated at different boric acid concentrations. The volatility of boric acid is enhanced significantly in the presence of steam. Equations are given that allow the effective vapour pressure of boric acid to be determined as functions of the water vapour pressure for temperatures in the range from 723 to 1000 o C. These data are confirmed by experimental studies designed to simulate specific aspects of the conditions in the Phebus-FP tests. (author)

  11. 76 FR 81360 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

    Science.gov (United States)

    2011-12-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. FAA-2011-1172: Special Conditions No. 25-453-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G280... Aerospace LP (GALP) Model G280 airplane. This airplane will have a novel or unusual design feature...

  12. Assessment of RELAP/MOD2 using large break loss-of-coolant experimental data

    International Nuclear Information System (INIS)

    Kao, L.; Liao, L.Y.; Liang, K.S.; Wang, S.F.; Chen, Y.B.

    1989-01-01

    In this paper assessment of RELAP5/MOD2 using LOFT L2-5 and Semiscale S-06-3 tests are performed to provide information of the code capability and its limitation in analyzing large break LOCA of a nuclear power plant. Experiments L2-5 and S-06-3 are conducted to simulate a hypothetical LOCA which results from a 200% double-ended offset shear break in the cold-leg of a typical pressurized water reactor by utilizing scaling facilities of the LOFT and Semiscale Mod-1 systems, respectively. The RELAP5/MOD2 calculations for both tests begin with break initiation and subsequent blowdown, continue through lower plenum refill, core reflood, and terminate with corewide quench. Major phenomena of both large break loss-of-coolant tests are well predicted by RELAP5/MOD2. The results indicate that the break flow and system pressure are reasonably calculated. The cladding temperature response during blowdown period, which is the major importance to a large break LOCA, calculated by RELAP5/MOD2 shows good agreement with the test data

  13. Quantification of Iodine-123-FP-CIT SPECT with a resolution-independent method

    International Nuclear Information System (INIS)

    Dobbeleir, A.A.; Ham, H.R.; Hambye, A.E.; Vervaet, A.M.

    2005-01-01

    Accurate quantification of small-sized objects by SPECT is hampered by the partial volume effect. The present work evaluates the magnitude of this phenomenon with Iodine- 123 in phantom studies, and presents a resolution- independent method to quantify striatal I-123 FP-CIT uptake in patients. At first five syringes with internal diameters varying between 9 and 29mm and an anthropomorphic striatal phantom were filled with known concentrations of Iodine-123 and imaged by SPECT using different collimators and radii of rotation. Data were processed with and without scatter correction. From the measured activities, calibration factors were calculated for each specific collimator. Then a resolution-independent method for FP-CIT quantification using large regions of interest was developed and validated in 34 human studies (controls and patients) acquired in 2 different hospitals, by comparing its results to those obtained by a semi- quantitative striatal-to-occipital analysis. Taking the injected activity and decay into account, the measured counts/volume could be converted into absolute tracer concentrations. For the fan-beam, high resolution and medium energy collimators, the measured maximum activity in comparison to the 29 mm-diameter syringe was respectively 38%, 16% and 9% for the 9 mm-diameter syringe and 82%, 80% and 30% for the 16 mm syringe, and not significantly modified after scatter correction. For the anthropomorphic phantom, the error in measurement in % of the true concentration ranged between 0.3-9.5% and was collimator dependent. Medium energy collimators yielded the most homogeneous results. In the human studies, inter- observer variability was 11.4% for the striatal-to-occipital ratio and 3.1% for the resolution-independent method, with correlation coefficients >0.8 between both. The resolution- independent method was 89%-sensitive and 100%-specific to separate the patients without and with abnormal FP-CIT uptake (accuracy: 94%). Also the

  14. Diagnostic value of asymmetric striatal D2 receptor upregulation in Parkinson's disease: an [123I]IBZM and [123I]FP-CIT SPECT study

    International Nuclear Information System (INIS)

    Verstappen, C.C.P.; Bloem, B.R.; Haaxma, C.A.; Horstink, M.W.I.M.; Oyen, W.J.G.

    2007-01-01

    Striatal postsynaptic D 2 receptors in Parkinson's disease (PD) are thought to be upregulated in the first years of the disease, especially contralateral to the clinically most affected side. The aim of this study was to evaluate whether the highest striatal D 2 binding is found contralateral to the most affected side in PD, and whether this upregulation can be used as a diagnostic tool. Cross-sectional survey was undertaken of 81 patients with clinically asymmetric PD, without antiparkinsonian drugs and with a disease duration of ≤5 years and 26 age-matched controls. Striatal D 2 binding was assessed with [ 123 I]IBZM SPECT, and severity of the presynaptic dopaminergic lesion with [ 123 I]FP-CIT SPECT. The mean striato-occipital ratio of [ 123 I]IBZM binding was significantly higher in PD patients (1.56 ±0.09) than in controls (1.53 ±0.06). In PD patients, higher values were found contralateral to the clinically most affected side (1.57 ±0.09 vs 1.55 ±0.10 ipsilaterally), suggesting D 2 receptor upregulation, and the reverse was seen using [ 123 I]FP-CIT SPECT. However, on an individual basis only 56% of PD patients showed this upregulation. Our study confirms asymmetric D 2 receptor upregulation in PD. However, the sensitivity of contralateral higher striatal [ 123 I]IBZM binding is only 56%. Therefore, the presence of contralateral higher striatal IBZM binding has insufficient diagnostic accuracy for PD, and PD cannot be excluded in patients with parkinsonism and no contralateral upregulation of D 2 receptors, assessed with [ 123 I]IBZM SPECT. (orig.)

  15. Unmet Need for Contraception among Clients of FP/HIV Integrated ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    1 Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill,. Chapel Hill ... Keywords: Partner opposition, contraceptive use, HIV/FP service integration, Nigeria ..... new programs/policies that consider gender and cultural influence on family planning service.

  16. 76 FR 25229 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Dynamic Test Requirements...

    Science.gov (United States)

    2011-05-04

    ... Memorandum ``Side-Facing Seats on Transport Category Airplanes'' and draft Issue Paper ``Dynamic Test...; Special Conditions No. 25-425-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane... are issued for the Gulfstream Aerospace LP (GALP) model G250 airplane. This airplane will have a novel...

  17. 77 FR 71680 - Buckeye East Chicago Railroad, LLC-Acquisition and Operation Exemption-Buckeye Partners, L.P.

    Science.gov (United States)

    2012-12-03

    ... Chicago Railroad, LLC--Acquisition and Operation Exemption--Buckeye Partners, L.P. Buckeye East Chicago... acquire from Buckeye Partners, L.P., a noncarrier, and to operate approximately 7,065 feet (1.34 miles) of..., 2012. By the Board, Rachel D. Campbell, Director, Office of Proceedings. Jeffrey Herzig, Clearance Unit...

  18. 76 FR 66660 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

    Science.gov (United States)

    2011-10-27

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. FAA-2011-1172: Notice No. 25-11-17-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane... Aerospace LP (GALP) Model G280 airplane. This airplane will have a novel or unusual design feature...

  19. Using MERRA-2 analysis fields to simulate limb scattered radiance profiles for inhomogeneous atmospheric lines of sight: Preparation for data assimilation of OMPS LP radiances through 2D single-scattering GSLS radiative transfer model development

    Science.gov (United States)

    Loughman, R. P.; Bhartia, P. K.; Moy, L.; Kramarova, N. A.; Wargan, K.

    2016-12-01

    Many remote sensing techniques used to monitor the Earth's upper atmosphere fall into the broad category of "limb viewing" (LV) measurements, which includes any method for which the line of sight (LOS) fails to intersect the surface. Occultation, limb emission and limb scattering (LS) measurements are all LV methods that offer strong sensitivity to changes in the atmosphere near the tangent point of the LOS, due to the enhanced geometric path through the tangent layer (where the concentration also typically peaks, for most atmospheric species). But many of the retrieval algorithms used to interpret LV measurements assume that the atmosphere consists of "spherical shells", in which the atmospheric properties vary only with altitude (creating a 1D atmosphere). This assumption simplifies the analysis, but at the possible price of misinterpreting measurements made in the real atmosphere. In this presentation, we focus on the problem of LOS inhomogeneity for LS measurements made by the OMPS Limb Profiler (LP) instrument during the 2015 ozone hole period. The GSLS radiative transfer model (RTM) used in the default OMPS LP algorithms assumes a spherical-shell atmosphere defined at levels spaced 1 km apart, with extinction coefficients assumed to vary linearly with height between levels. Several recent improvements enable an updated single-scattering version of the GSLS RTM to ingest 3D MERRA-2 analysis fields (including temperature, pressure, and ozone concentration) when creating the model atmosphere, by introducing flexible altitude grids, flexible atmospheric specification along the LOS, and improved treatment of the radiative transfer within each atmospheric layer. As a result, the effect of LOS inhomogeneity on the current (1D) OMPS LP retrieval algorithm can now be studied theoretically, using realistic 3D atmospheric profiles. This work also represents a step towards enabling OMPS LP data to be ingested as part of future data assimilation efforts.

  20. 77 FR 77122 - Pyxis Capital, L.P., et al.;

    Science.gov (United States)

    2012-12-31

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30316; 812-13489-01] Pyxis Capital, L.P., et al.; Notice of Application December 21, 2012. AGENCY: Securities and Exchange Commission (the ``Commission''). ACTION: Notice of an application for an order under section 6(c) of the...

  1. Young People's Preferences for Family Planning Service Providers in Rural Malawi: A Discrete Choice Experiment.

    Directory of Open Access Journals (Sweden)

    Christine Michaels-Igbokwe

    Full Text Available To quantify the impact of service provider characteristics on young people's choice of family planning (FP service provider in rural Malawi in order to identify strategies for increasing access and uptake of FP among youth.A discrete choice experiment was developed to assess the relative impact of service characteristics on preferences for FP service providers among young people (aged 15-24. Four alternative providers were included (government facility, private facility, outreach and community based distribution of FP and described by six attributes (the distance between participants' home and the service delivery point, frequency of service delivery, waiting time at the facility, service providers' attitude, availability of FP commodities and price. A random parameters logit model was used to estimate preferences for service providers and the likely uptake of services following the expansion of outreach and community based distribution (CBDA services. In the choice experiment young people were twice as likely to choose a friendly provider (government service odds ratio [OR] = 2.45, p<0.01; private service OR = 1.99, p<0.01; CBDA OR = 1.88, p<0.01 and more than two to three times more likely to choose a provider with an adequate supply of FP commodities (government service OR = 2.48, p<0.01; private service OR = 2.33, p<0.01; CBDA = 3.85, p<0.01. Uptake of community based services was greater than facility based services across a variety of simulated service scenarios indicating that such services may be an effective means of expanding access for youth in rural areas and an important tool for increasing service uptake among youth.Ensuring that services are acceptable to young people may require additional training for service providers in order to ensure that all providers are friendly and non-judgemental when dealing with younger clients and to ensure that supplies are consistently available.

  2. One particle-hole excitations in p- and fp-shell nuclei

    International Nuclear Information System (INIS)

    Hees, A.G.M. van.

    1982-01-01

    Results are presented of shell model calculations of medium and light atomic nuclei. The influence of the allowance of one particle-hole excitations is investigated. This enables improved descriptions of intermediate mass nuclei in the fp-shell. For light p-shell nuclei one particle-hole excitations create exclusively situations with abnormal parity. The description of situations with normal parity is not changed by enlarging the model space. In the first chapter shell-model calculations are performed on the light Ni-isotopes (A = 57-59). One nucleon is allowed to be excited from the fsub(7/2) orbit to one of the other fp-shell orbits. The general observation in the enlarged model space is that one can use operators that require a much weaker 'renormalization' and the calculation requires only a selected set of matrix elements of the Hamiltonian. An additional advantage of the inclusion of one particle-hole excitations is that it allows a description of several intruder states, i.e. states that cannot be produced with the assumption of a closed 56 Ni core. In the second chapter the nuclei with mass number A = 52-55, i.e. a small number of holes in the 56 Ni core, are investigated similarly. In the third chapter much lighter nuclei (A = 4-16) are discussed. For a theoretical description of nonnormal-parity states one has to admit the excitation of at least one nucleon to a higher harmonic-oscillator major-shell. (Auth.)

  3. Continuous and Lp estimates for the complex Monge-Ampère equation on bounded domains in ℂn

    Directory of Open Access Journals (Sweden)

    Patrick W. Darko

    2002-01-01

    Full Text Available Continuous solutions with continuous data and Lp solutions with Lp data are obtained for the complex Monge-Ampère equation on bounded domains, without requiring any smoothness of the domains.

  4. Combined visual and semi-quantitative assessment of 123I-FP-CIT SPECT for the diagnosis of dopaminergic neurodegenerative diseases.

    Science.gov (United States)

    Ueda, Jun; Yoshimura, Hajime; Shimizu, Keiji; Hino, Megumu; Kohara, Nobuo

    2017-07-01

    Visual and semi-quantitative assessments of 123 I-FP-CIT single-photon emission computed tomography (SPECT) are useful for the diagnosis of dopaminergic neurodegenerative diseases (dNDD), including Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. However, the diagnostic value of combined visual and semi-quantitative assessment in dNDD remains unclear. Among 239 consecutive patients with a newly diagnosed possible parkinsonian syndrome who underwent 123 I-FP-CIT SPECT in our medical center, 114 patients with a disease duration less than 7 years were diagnosed as dNDD with the established criteria or as non-dNDD according to clinical judgment. We retrospectively examined their clinical characteristics and visual and semi-quantitative assessments of 123 I-FP-CIT SPECT. The striatal binding ratio (SBR) was used as a semi-quantitative measure of 123 I-FP-CIT SPECT. We calculated the sensitivity and specificity of visual assessment alone, semi-quantitative assessment alone, and combined visual and semi-quantitative assessment for the diagnosis of dNDD. SBR was correlated with visual assessment. Some dNDD patients with a normal visual assessment had an abnormal SBR, and vice versa. There was no statistically significant difference between sensitivity of the diagnosis with visual assessment alone and semi-quantitative assessment alone (91.2 vs. 86.8%, respectively, p = 0.29). Combined visual and semi-quantitative assessment demonstrated superior sensitivity (96.7%) to visual assessment (p = 0.03) or semi-quantitative assessment (p = 0.003) alone with equal specificity. Visual and semi-quantitative assessments of 123 I-FP-CIT SPECT are helpful for the diagnosis of dNDD, and combined visual and semi-quantitative assessment shows superior sensitivity with equal specificity.

  5. 78 FR 28273 - Alpine Investors IV SBIC, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2013-05-14

    ... SMALL BUSINESS ADMINISTRATION [License No. 09/09-0461] Alpine Investors IV SBIC, LP; Notice... hereby given that Alpine Investors IV SBIC, LP, 3 Embarcadero Center, Suite 2330, San Francisco, CA, a...'') Rules and [[Page 28274

  6. 78 FR 68044 - Erie Boulevard Hydropower, L.P.; Notice of Scoping Meetings and Environmental Site Review and...

    Science.gov (United States)

    2013-11-13

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7320-042] Erie Boulevard Hydropower, L.P.; Notice of Scoping Meetings and Environmental Site Review and Soliciting Scoping Comments.... Date filed: July 1, 2013. d. Applicant: Erie Boulevard Hydropower, L.P. e. Name of Project: Chasm...

  7. Chronic motor cortex stimulation in patients with advanced Parkinson's disease and effects on striatal dopaminergic transmission as assessed by 123I-FP-CIT SPECT: a preliminary report.

    Science.gov (United States)

    Di Giuda, Daniela; Calcagni, Maria L; Totaro, Manuela; Cocciolillo, Fabrizio; Piano, Carla; Soleti, Francesco; Fasano, Alfonso; Cioni, Beatrice; Bentivoglio, Anna R; Giordano, Alessandro

    2012-09-01

    The objective of this study was to assess striatal dopamine transporter availability in patients with advanced Parkinson's disease (PD) before and after 13 months of unilateral extradural motor cortex stimulation (EMCS) with [123I]N-ω-fluoropropyl-2-β-carbo-methoxy-3-β-(4-iodophenyl)nortropane single photon emission computed tomography (123I-FP-CIT SPECT). Six PD patients (five women and one man, aged 63.2 ± 5.6 years) underwent 123I-FP-CIT SPECT and clinical evaluation [Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Quality of Life Scale (PDQL)] preoperatively, 8 and 13 months after EMCS. Striatum-to-occipital cortex, caudate-to-occipital cortex and putamen-to-occipital cortex 123I-FP-CIT uptake ratios were calculated using the region of interest method. Total and part III UPDRS scores significantly decreased at 8 and 13 months after stimulation (P=0.02 and 0.04, respectively); UPDRS part II and PDQL scores improved after 13 months (P=0.02 and 0.04, respectively). No significant differences in 123I-FP-CIT uptake ratios between baseline and follow-up were found in the examined regions. However, a progressive reduction in 123I-FP-CIT uptake ratios in the striatum contralateral to the implant was found. In contrast, no further decrease in 123I-FP-CIT uptake ratios was detected in the striatum ipsilateral to the implant. There were no correlations between changes in 123I-FP-CIT uptake ratios with disease duration, changes in medication dosage and motor UPDRS scores. Despite a small but highly selected sample of advanced PD patients, our results showed that no further dopamine transporter reduction occurred in the striatum ipsilateral to the implant side. This finding could lead to the hypothesis that EMCS might elicit a 'neuroprotective' effect, as suggested by significant clinical benefits.

  8. Application of analytical capability to predict rapid cladding cooling and quench during the blowdown phase of a large break loss-of-coolant accident

    International Nuclear Information System (INIS)

    Aksan, S.N.; Tolman, E.L.; Nelson, R.A.

    1983-01-01

    Large-break Experiments L2-2 and L2-3 conducted in the Loss-of-Fluid Test (LOFT) facility experienced core-wide rapid quenches early in the blowdown transients. To further investigate rapid cladding quenches, separate effects experiments using Semiscale solid-type electric heater rods were conducted in the LOFT Test Support Facility (LTSF) over a wide range of inlet coolant conditions. The analytical capability to predict the cladding temperature response from selected LTSF experiments estimated to bound the hydraulic conditions causing the LOFT early blowdown quenches was investigated using the RELAP4 computer code and was shown to be acceptable over the film boiling cooldown phase. This analytical capability was then used to investigate the behavior of nuclear fuel rods under the same hydraulic conditions. The calculations show that, under rapid cooling conditions, the behaviors of nuclear and electrical heater rods are significantly different because the nuclear rods are conduction limited, while the electrical rods are convection limited

  9. LP 400-22, A Very Low Mass and High-Velocity White Dwarf

    Science.gov (United States)

    Kawka, Adela; Vennes, Stephane; Oswalt, Terry D.; Smith, J. Allyn; Silvestri, Nicole M.

    2006-01-01

    We report the identification of LP 400-22 (WD 2234+222) as a very low mass and high-velocity white dwarf. The ultraviolet GALEX and optical photometric colors and a spectral line analysis of LP 400-22 show this star to have an effective temperature of 11,080+/-140 K and a surface gravity of log g = 6.32 +/-0.08. Therefore, this is a helium-core white dwarf with a mass of 0.17 M,. The tangential velocity of this white dwarf is 414+/-43 km/s, making it one of the fastest moving white dwarfs known. We discuss probable evolutionary scenarios for this remarkable object.

  10. Beta Decay Study of the T{sub z}=−2{sup 56}Zn Nucleus and the Determination of the Half-Lives of a Few fp-shell Nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Rubio, B., E-mail: Berta.Rubio@ific.uv.es [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Orrigo, S.E.A. [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Kucuk, L. [Department of Physics, Istanbul University, Istanbul (Turkey); Montaner-Pizá, A. [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Fujita, Y. [Department of Physics, Osaka University, Toyonaka, Osaka 560-0043 (Japan); RCNP, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Fujita, H. [RCNP, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Blank, B. [CENBG, Université Bordeaux 1, UMR 5797 CNRS/IN2P3, BP 120, F-33175 Gradignan (France); Gelletly, W. [Department of Physics, University of Surrey, Guildford GU2 7XH, Surrey (United Kingdom); Adachi, T. [RCNP, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Agramunt, J.; Algora, A. [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Ascher, P. [CENBG, Université Bordeaux 1, UMR 5797 CNRS/IN2P3, BP 120, F-33175 Gradignan (France); Bilgier, B. [Department of Physics, Istanbul University, Istanbul (Turkey); Cáceres, L. [GANIL, CEA/DSM-CNRS/IN2P3, BP 55027, F-14076 Caen (France); Cakirli, R.B. [Department of Physics, Istanbul University, Istanbul (Turkey); France, G. de [GANIL, CEA/DSM-CNRS/IN2P3, BP 55027, F-14076 Caen (France); Ganioğlu, E. [Department of Physics, Istanbul University, Istanbul (Turkey); Gerbaux, M.; Giovinazzo, J.; Grevy, S. [CENBG, Université Bordeaux 1, UMR 5797 CNRS/IN2P3, BP 120, F-33175 Gradignan (France); and others

    2014-06-15

    This paper concerns the experimental study of the β decay properties of few proton-rich fp-shell nuclei. The nuclei were produced at GANIL in fragmentation reactions, separated with the LISE spectrometer and stopped in an implantation detector surrounded by Ge detectors. The β-delayed gammas, β-delayed protons and the exotic β-delayed gamma-proton emission have been studied. Preliminary results are presented. The decay of the T{sub z}=−2 nucleus {sup 56}Zn has been studied in detail. Information from the β-delayed protons and β-delayed gammas has been used to deduce the decay scheme. The exotic beta-delayed gamma-proton decay has been observed for the first time in the fp-shell. The interpretation of the data was made possible thanks to the detailed knowledge of the mirror Charge Exchange (CE) process and the gamma de-excitation of the states in {sup 56}Co, the mirror nucleus of {sup 56}Cu.

  11. 77 FR 20871 - Praesidian Capital Opportunity Fund III, LP; License No. 02/02-0647; Notice Seeking Exemption...

    Science.gov (United States)

    2012-04-06

    ... contemplated to fund working capital and capital expenditures. The financing is brought within the purview of... SMALL BUSINESS ADMINISTRATION Praesidian Capital Opportunity Fund III, LP; License No. 02/02- 0647... given that Praesidian Capital Opportunity Fund III, LP, 419 Park Avenue South, New York, NY 10016, a...

  12. 75 FR 6414 - Cardinal Growth, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2010-02-09

    ... SMALL BUSINESS ADMINISTRATION [License No. 05/75-0257] Cardinal Growth, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Cardinal Growth, L.P., 311 South Wacker Driver, Suite 5500, Chicago, IL 60606, a Federal...

  13. 78 FR 77770 - Ironwood Equity Fund, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2013-12-24

    ... proposes to Finance a small business in which its Associate Ironwood Mezzanine Fund II, LP has an equity... SMALL BUSINESS ADMINISTRATION [ License No. 01171-0406] Ironwood Equity Fund, LP; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby...

  14. 78 FR 62348 - Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing and Soliciting Motions...

    Science.gov (United States)

    2013-10-18

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7320-042] Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing and Soliciting Motions To Intervene and Protests.... Date filed: July 1, 2013. d. Applicant: Erie Boulevard Hydropower, L.P. e. Name of Project: Chasm...

  15. Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB

    NARCIS (Netherlands)

    van der Hoek, Y. Y.; Lingenhel, A.; Kraft, H. G.; Defesche, J. C.; Kastelein, J. J.; Utermann, G.

    1997-01-01

    Whether or not Lp(a) plasma levels are affected by the apoB R3500Q mutation, which causes Familial Defective apoB (FDB), is still a matter of debate. We have analyzed 300 family members of 13 unrelated Dutch index patients for the apoB mutation and the apolipoprotein(a) [apo(a)] genotype. Total

  16. Sparse filtering with the generalized lp/lq norm and its applications to the condition monitoring of rotating machinery

    Science.gov (United States)

    Jia, Xiaodong; Zhao, Ming; Di, Yuan; Li, Pin; Lee, Jay

    2018-03-01

    Sparsity is becoming a more and more important topic in the area of machine learning and signal processing recently. One big family of sparse measures in current literature is the generalized lp /lq norm, which is scale invariant and is widely regarded as normalized lp norm. However, the characteristics of the generalized lp /lq norm are still less discussed and its application to the condition monitoring of rotating devices has been still unexplored. In this study, we firstly discuss the characteristics of the generalized lp /lq norm for sparse optimization and then propose a method of sparse filtering with the generalized lp /lq norm for the purpose of impulsive signature enhancement. Further driven by the trend of industrial big data and the need of reducing maintenance cost for industrial equipment, the proposed sparse filter is customized for vibration signal processing and also implemented on bearing and gearbox for the purpose of condition monitoring. Based on the results from the industrial implementations in this paper, the proposed method has been found to be a promising tool for impulsive feature enhancement, and the superiority of the proposed method over previous methods is also demonstrated.

  17. Variation in LPA is associated with Lp(a levels in three populations from the Third National Health and Nutrition Examination Survey.

    Directory of Open Access Journals (Sweden)

    Logan Dumitrescu

    2011-01-01

    Full Text Available The distribution of lipoprotein(a [Lp(a] levels can differ dramatically across diverse racial/ethnic populations. The extent to which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were genotyped in 7,159 participants from the Third National Health and Nutrition Examination Survey (NHANES III. NHANES III is a diverse population-based survey with DNA samples linked to hundreds of quantitative traits, including serum Lp(a. Tests of association between LPA variants and transformed Lp(a levels were performed across the three different NHANES subpopulations (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. At a significance threshold of p<0.0001, 15 of the 19 SNPs tested were strongly associated with Lp(a levels in at least one subpopulation, six in at least two subpopulations, and none in all three subpopulations. In non-Hispanic whites, three variants were associated with Lp(a levels, including previously known rs6919246 (p = 1.18 × 10(-30. Additionally, 12 and 6 variants had significant associations in non-Hispanic blacks and Mexican Americans, respectively. The additive effects of these associated alleles explained up to 11% of the variance observed for Lp(a levels in the different racial/ethnic populations. The findings reported here replicate previous candidate gene and genome-wide association studies for Lp(a levels in European-descent populations and extend these findings to other populations. While we demonstrate that LPA is an important contributor to Lp(a levels regardless of race/ethnicity, the lack of generalization of associations across all subpopulations suggests that specific LPA variants may be contributing to the observed Lp(a between-population variance.

  18. The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.

    Science.gov (United States)

    Lima, G M G; Corazza, B J M; Moraes, R M; de Oliveira, F E; de Oliveira, L D; Franco, G C N; Perrien, D S; Elefteriou, F; Anbinder, A L

    2016-10-01

    LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. Twenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed. Significant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen. LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. 75 FR 13755 - Freeport LNG Development, L.P.; Application To Amend Blanket Authorization To Export Liquefied...

    Science.gov (United States)

    2010-03-23

    ... Delaware limited partnership with one general partner, Freeport LNG-GP, Inc., a Delaware corporation, which...). Freeport LNG's limited partners are: (1) Freeport LNG Investments, LLLP, a Delaware limited liability limited partnership, which owns a 45% limited partnership interest in Freeport LNG; (2) Cheniere FLNG, L.P...

  20. 78 FR 48177 - Purdue Pharma L.P.; Withdrawal of Approval of a New Drug Application for Oxycontin

    Science.gov (United States)

    2013-08-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0883] Purdue Pharma L.P.; Withdrawal of Approval of a New Drug Application for Oxycontin AGENCY: Food and Drug... Purdue Pharma L.P. (Purdue), One Stamford Forum, Stamford, CT 06901-3431. Purdue has voluntarily...