WorldWideScience

Sample records for local plan topic

  1. Updates of Topical and Local Anesthesia Agents.

    Science.gov (United States)

    Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

    2016-04-01

    As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Enhanced radiological work planning; TOPICAL

    International Nuclear Information System (INIS)

    DECKER, W.A.

    1999-01-01

    The purpose of this standard is to provide Project Hanford Management Contractors (PHMC) with guidance for ensuring radiological considerations are adequately addressed throughout the work planning process. Incorporating radiological controls in the planning process is a requirement of the Hanford Site Radiological Control Manual (HSRCM-I), Chapter 3, Part 1. This standard is applicable to all PHMC contractors and subcontractors. The essential elements of this standard will be incorporated into the appropriate site level work control standard upon implementation of the anticipated revision of the PHMC Administration and Procedure System

  3. Riser equipment decontamination engineering task plan; TOPICAL

    International Nuclear Information System (INIS)

    BOGER, R.M.

    1999-01-01

    On October 15, 1998, two Characterization Project Operations (CPO) employees were found to have contaminated clothing. An operator had 300,000-dpm/100cm2 beta/gamma, no alpha, contamination on his coat sleeve and a Radiation Control Technician (RCT) had 10,000 dpm/100cm2 beta/gamma, no alpha, on his shirt sleeve. The CPO swing shift crew was working in TX tank farm, performing sampling activities at 241-TX-113. TX tank farm is a ''clean farm'' and does not require anti-contamination clothing for entry. The CPO personnel were dressed in normal work clothes. An operator and an RCT were performing a pre-job survey that involved removing bagging around the riser equipment. When the RCT saw that the contamination readings from smear samples of the riser equipment were greater than expected, the job was suspended. Crew members were then directed to areas of lower background radiation for personnel surveys. During personnel surveys, reportable contamination was found on the coat sleeve of the operator who had been involved in the pre-job survey and on the shirt sleeve of the RCT who had been involved in the pre-job survey. No other personnel were found to be contaminated. Because of this off normal event Characterization Engineering was given the following corrective action: Examine the process methodology used for core sampling operations to determine practicality and potential long-term advantages of reducing personnel contact with contaminated equipment. This Engineering Task Plan ensures that LMHC 1998a, Corrective Action No.7 is completely addressed by Characterization Engineering. The deliverable is an Engineering Study that evaluates decontamination of riser equipment components and considers additional engineered features to reduce potential exposure to workers operating the riser equipment. This engineering study shall also address any released design features that have failed to be implemented

  4. Emergency planning and management in health care: priority research topics.

    Science.gov (United States)

    Boyd, Alan; Chambers, Naomi; French, Simon; Shaw, Duncan; King, Russell; Whitehead, Alison

    2014-06-01

    Many major incidents have significant impacts on people's health, placing additional demands on health-care organisations. The main aim of this paper is to suggest a prioritised agenda for organisational and management research on emergency planning and management relevant to U.K. health care, based on a scoping study. A secondary aim is to enhance knowledge and understanding of health-care emergency planning among the wider research community, by highlighting key issues and perspectives on the subject and presenting a conceptual model. The study findings have much in common with those of previous U.S.-focused scoping reviews, and with a recent U.K.-based review, confirming the relative paucity of U.K.-based research. No individual research topic scored highly on all of the key measures identified, with communities and organisations appearing to differ about which topics are the most important. Four broad research priorities are suggested: the affected public; inter- and intra-organisational collaboration; preparing responders and their organisations; and prioritisation and decision making.

  5. Reindeer husbandry and local planning

    Directory of Open Access Journals (Sweden)

    Lars P. Niia

    1986-06-01

    Full Text Available A central theme in the reindeer husbandry is the conflicts between this and other economic interests as tourism, community development etc. in connection with the utilization of common territory. A retrospective glance will show that this is an old problem and not a new phenomenon. The Nordic Sami Institute has carried out a research project with the following objectives: 1.to give an account of the terms of planning for the reindeer husbandry, 2.to find out how the Såmi (Lapp community's and so the reindeer husbandry's interests are taken into account in local planning. 3.find ways for how the reindeer husbandry's use of land can be described. 4.give suggestions as to how the interests of the Sami community can better be taken into account or how it can increase its influence in relation to planning. The suggestions based upon the results from the research project are: —that the Sami community aquire competence by preparing itself for the changes in its environment. —that it builds up its own organization. —that it aquires a more noticeable influence in community planning and decision making. This project and earlier experiencies have shown that the way of influencing e.g. by land-use-planning is weak and unreliable today.Renskötsel och kommunal planering.Abstract in Swedish / Sammandrag: Ett centralt tema i renskotselsammanhang ar konflikterna mellan renskotsel och andra ekonomiska intressen som turism, samhållsutbyggnad etc. vid utnyttjande av gemensamma arealer. En historisk tillbakablick visar att denna problematik inte på något sått år någon ny foreteelse utan ett gammalt tema med variationer i tid och rum. I ett forskningsprojekt vid Sami Instituhtta har en studie genomforts med syftet att: 1.soka beskriva planeringsforutsåttningarna for renskotseln. 2. soka forklara hur renskotselns intressen tas tillvara i den kommunala fysiska planeringen. 3. finna former for hur renskotselns markanvåndning kan beskrivas. 4. att l

  6. Danish Experience in Local Energy Planning

    DEFF Research Database (Denmark)

    Lund, Henrik; Sørensen, Per Alex

    2003-01-01

    The paper describes the influence from public participation brings examples of local energy planning from Ærø and Samsø islands in Denmark.......The paper describes the influence from public participation brings examples of local energy planning from Ærø and Samsø islands in Denmark....

  7. Adjustment of legally binding local plans

    DEFF Research Database (Denmark)

    Hvingel, Line Træholt; Aunsborg, Christian; Christensen, Finn Kjær

    2012-01-01

    Traditionally, and by law, new urban areas in Denmark are regulated and planned through legally binding local plans. Recently a tendency has occurred: The municipalities make the legally binding local plans quite open for future adjustment, and they are using a substantial amount of ‘empowerment ...... the considerations of legal rights, the extend of the legal use of empowerment provisions and the combination of the use of legal binding local plans and other legal instruments such as easements and sales agreements.......Traditionally, and by law, new urban areas in Denmark are regulated and planned through legally binding local plans. Recently a tendency has occurred: The municipalities make the legally binding local plans quite open for future adjustment, and they are using a substantial amount of ‘empowerment...... provisions’ which empower the municipalities to later ruling. This way of making plans postpones the actual regulation of an area (i.e. the planning permission) making it an individual ruling for instance at the application of building permits. Case studies show examples of this way of regulating an area...

  8. The effect of local/topical analgesics on incisional pain in a pig model

    Directory of Open Access Journals (Sweden)

    Castel D

    2017-09-01

    Full Text Available David Castel,1 Itai Sabbag,2 Sigal Meilin3 1The Neufeld Cardiac Research Institute, Sheba Medical Centre, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, 2Lahav Research Institute, Kibutz Lahav, Negev, 3Neurology R&D Division, MD Biosciences, Nes-Ziona, Israel Abstract: Interest in the development of new topical/local drug administration for blocking pain at peripheral sites, with maximum drug activity and minimal systemic effects, is on the rise. In the review article by Kopsky and Stahl, four critical barriers in the process of research and development of topical analgesics were indicated. The active pharmaceutical ingredient (API and the formulation are among the major challenges. The road to the development of such drugs passes through preclinical studies. These studies, if planned correctly, should serve as guidance for choosing the right API and formulation. Although rodent models for pain continue to provide valuable data on the mechanisms driving pain, their use in developing topical and localized treatment approaches is limited for technical (intraplate injection area is small as well as mechanical reasons (non-similarity to human skin and innervation. It has been previously shown that pigs are comparable to humans in ways that make them a better choice for evaluating topical and local analgesics. The aim of this study was to summarize several experiments that used pigs for testing postoperative pain in an incisional pain model (skin incision [SI] and skin and muscle incision [SMI]. At the end of the surgery, the animals were treated with different doses of bupivacaine solution (Marcaine®, bupivacaine liposomal formulation (Exparel® or ropivacaine solution (Naropin. Von Frey testing demonstrated a decrease in the animals’ sensitivity to mechanical stimulation expressed as an increase in the withdrawal force following local treatment. These changes reflect the clinical condition in the level as well as in the duration of

  9. Local Emergency Planning Committee (LEPC) Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — The LEPC data set contains over 3000 listings, as of 2008, for name and location data identifying Local Emergency Planning Committees (LEPCs). LEPCs are people...

  10. Topical bioavailability of diclofenac from locally-acting, dermatological formulations.

    Science.gov (United States)

    Cordery, S F; Pensado, A; Chiu, W S; Shehab, M Z; Bunge, A L; Delgado-Charro, M B; Guy, R H

    2017-08-30

    Assessment of the bioavailability of topically applied drugs designed to act within or beneath the skin is a challenging objective. A number of different, but potentially complementary, techniques are under evaluation. The objective of this work was to evaluate in vitro skin penetration and stratum corneum tape-stripping in vivo as tools with which to measure topical diclofenac bioavailability from three approved and commercialized products (two gels and one solution). Drug uptake into, and its subsequent clearance from, the stratum corneum of human volunteers was used to estimate the input rate of diclofenac into the viable skin layers. This flux was compared to that measured across excised porcine skin in conventional diffusion cells. Both techniques clearly demonstrated (a) the superiority in terms of drug delivery from the solution, and (b) that the two gels performed similarly. There was qualitative and, importantly, quantitative agreement between the in vitro and in vivo measurements of drug flux into and beyond the viable skin. Evidence is therefore presented to support an in vivo - in vitro correlation between methods to assess topical drug bioavailability. The potential value of the stratum corneum tape-stripping technique to quantify drug delivery into (epi)dermal and subcutaneous tissue beneath the barrier is demonstrated. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Health contribution to local government planning

    International Nuclear Information System (INIS)

    France, Cheryl

    2004-01-01

    When local government considers future land-use plans, the local health authorities are not always included as a key partner. In Cambridgeshire, England, the former Cambridgeshire Health Authority formed a partnership with local government to address this issue. The relationship that developed and the subsequent health impact review provided an opportunity to influence strategic policy and ensure that health objectives are taken into account. Through partnership working, lessons were learned about how to incorporate health issues into a strategic land-use planning document to the overall benefit of the community

  12. EDITORIAL: International Workshop on Current Topics in Monte Carlo Treatment Planning

    Science.gov (United States)

    Verhaegen, Frank; Seuntjens, Jan

    2005-03-01

    The use of Monte Carlo particle transport simulations in radiotherapy was pioneered in the early nineteen-seventies, but it was not until the eighties that they gained recognition as an essential research tool for radiation dosimetry, health physics and later on for radiation therapy treatment planning. Since the mid-nineties, there has been a boom in the number of workers using MC techniques in radiotherapy, and the quantity of papers published on the subject. Research and applications of MC techniques in radiotherapy span a very wide range from fundamental studies of cross sections and development of particle transport algorithms, to clinical evaluation of treatment plans for a variety of radiotherapy modalities. The International Workshop on Current Topics in Monte Carlo Treatment Planning took place at Montreal General Hospital, which is part of McGill University, halfway up Mount Royal on Montreal Island. It was held from 3-5 May, 2004, right after the freezing winter has lost its grip on Canada. About 120 workers attended the Workshop, representing 18 countries. Most of the pioneers in the field were present but also a large group of young scientists. In a very full programme, 41 long papers were presented (of which 12 were invited) and 20 posters were on display during the whole meeting. The topics covered included the latest developments in MC algorithms, statistical issues, source modelling and MC treatment planning for photon, electron and proton treatments. The final day was entirely devoted to clinical implementation issues. Monte Carlo radiotherapy treatment planning has only now made a slow entrée in the clinical environment, taking considerably longer than envisaged ten years ago. Of the twenty-five papers in this dedicated special issue, about a quarter deal with this topic, with probably many more studies to follow in the near future. If anything, we hope the Workshop served as an accelerator for more clinical evaluation of MC applications. The

  13. Business planning for scientists and engineers[3rd edition]; TOPICAL

    International Nuclear Information System (INIS)

    Servo, Jenny C.

    1999-01-01

    This combination text/workbook is intended for use by scientists or engineers actively engaged in developing a product or technology to commercial production. The 'how' of planning is a central theme with special emphasis on development of operational plans and strategic thinking

  14. Gabor frames on locally compact abelian groups and related topics

    DEFF Research Database (Denmark)

    Jakobsen, Mads Sielemann

    This thesis consists of four papers. The first one introduces generalized translation invariant systems and considers their frame properties, the second and third paper give new results on the theory of Gabor frames, and the fourth is a review paper with proofs and new results on the Feichtinger......- and shearlet-type and for (generalized) shift-invariant systems and their continuous formulations. This thesis advances the theory of both separable and non-separable, discrete, semicontinuous and continuous Gabor systems. In particular, the well established structure theory for separable lattice Gabor frames...... and Gabor Riesz bases. The theory of GTI systems and Gabor frames in this thesis is developed and presented in the setting of locally compact abelian groups, however, even in the euclidean setting the results given here improve the existing theory. Finally, the thesis contains a review paper with proofs...

  15. The Local Agenda 21 Planning Guide

    International Development Research Centre (IDRC) Digital Library (Canada)

    These “Local Agenda 21” action plans translate the principles and mandates of .... contract arrangements, and other practices must be adjusted to allow for the ..... US $70,000 and 40 percent of revenues from the taxes on mining operations. ...... in progress in the Sarawak of Malaysia and other Southeast Asian nations.

  16. Project Hanford management contract quality improvement project management plan; TOPICAL

    International Nuclear Information System (INIS)

    ADAMS, D.E.

    1999-01-01

    On July 13, 1998, the U.S. Department of Energy, Richland Operations Office (DOE-RL) Manager transmitted a letter to Fluor Daniel Hanford, Inc. (FDH) describing several DOE-RL identified failed opportunities for FDH to improve the Quality Assurance (QA) Program and its implementation. In addition, DOE-RL identified specific Quality Program performance deficiencies. FDH was requested to establish a periodic reporting mechanism for the corrective action program. In a July 17, 1998 response to DOE-RL, FDH agreed with the DOE concerns and committed to perform a comprehensive review of the Project Hanford Management Contract (PHMC) QA Program during July and August, 1998. As a result, the Project Hanford Management Contract Quality Improvement Plan (QIP) (FDH-3508) was issued on October 21, 1998. The plan identified corrective actions based upon the results of an in-depth Quality Program Assessment. Immediately following the scheduled October 22, 1998, DOE Office of Enforcement and Investigation (EH-10) Enforcement Conference, FDH initiated efforts to effectively implement the QIP corrective actions. A Quality Improvement Project (QI Project) leadership team was assembled to prepare a Project Management Plan for this project. The management plan was specifically designed to engage a core team and the support of representatives from FDH and the major subcontractors (MSCs) to implement the QIP initiatives; identify, correct, and provide feedback as to the root cause for deficiency; and close out the corrective actions. The QI Project will manage and communicate progress of the process

  17. Knowledge-Based Topic Model for Unsupervised Object Discovery and Localization.

    Science.gov (United States)

    Niu, Zhenxing; Hua, Gang; Wang, Le; Gao, Xinbo

    Unsupervised object discovery and localization is to discover some dominant object classes and localize all of object instances from a given image collection without any supervision. Previous work has attempted to tackle this problem with vanilla topic models, such as latent Dirichlet allocation (LDA). However, in those methods no prior knowledge for the given image collection is exploited to facilitate object discovery. On the other hand, the topic models used in those methods suffer from the topic coherence issue-some inferred topics do not have clear meaning, which limits the final performance of object discovery. In this paper, prior knowledge in terms of the so-called must-links are exploited from Web images on the Internet. Furthermore, a novel knowledge-based topic model, called LDA with mixture of Dirichlet trees, is proposed to incorporate the must-links into topic modeling for object discovery. In particular, to better deal with the polysemy phenomenon of visual words, the must-link is re-defined as that one must-link only constrains one or some topic(s) instead of all topics, which leads to significantly improved topic coherence. Moreover, the must-links are built and grouped with respect to specific object classes, thus the must-links in our approach are semantic-specific , which allows to more efficiently exploit discriminative prior knowledge from Web images. Extensive experiments validated the efficiency of our proposed approach on several data sets. It is shown that our method significantly improves topic coherence and outperforms the unsupervised methods for object discovery and localization. In addition, compared with discriminative methods, the naturally existing object classes in the given image collection can be subtly discovered, which makes our approach well suited for realistic applications of unsupervised object discovery.Unsupervised object discovery and localization is to discover some dominant object classes and localize all of object

  18. Coal Power Systems strategic multi-year program plans; TOPICAL

    International Nuclear Information System (INIS)

    None

    2001-01-01

    The Department of Energy's (DOE) Office of Fossil Energy (FE), through the Coal and Power Systems (C and PS) program, funds research to advance the scientific knowledge needed to provide new and improved energy technologies; to eliminate any detrimental environmental effects of energy production and use; and to maintain US leadership in promoting the effective use of US power technologies on an international scale. Further, the C and PS program facilitates the effective deployment of these technologies to maximize their benefits to the Nation. The following Strategic Plan describes how the C and PS program intends to meet the challenges of the National Energy Strategy to: (1) enhance American's energy security; (2) improve the environmental acceptability of energy production and use; (3) increase the competitiveness and reliability of US energy systems; and (4) ensure a robust US energy future. It is a plan based on the consensus of experts and managers from FE's program offices and the National Energy Technology Laboratory (NETL)

  19. PFP Interface identification and management planning guide; TOPICAL

    International Nuclear Information System (INIS)

    SINCLAIR, J.C.

    1999-01-01

    The purpose of-this planning guide is to present the process used to identify, document, and control PFP Stabilization and Deactivation Project interfaces. Revisions to this document will include, as attachments, the most recent version of the Project Interface Management List. A preliminary Interface Management List is included in Appendix A. This document is intended be a Project owned management tool. As such, this document will periodically require revisions resulting from improvements of the information, processes, and techniques as now described. For most revisions that suggest improved processes, PFP management approval is all that will be required

  20. Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study.

    Science.gov (United States)

    Chatterjee, Dattatreyo; Ghosh, Sudip Kumar; Sen, Sukanta; Sarkar, Saswati; Hazra, Avijit; De, Radharaman

    2016-01-01

    Epidermal dermatophyte infections most commonly manifest as tinea corporis or tinea cruris. Topical azole antifungals are commonly used in their treatment but literature suggests that most require twice-daily application and provide lower cure rates than the allylamine antifungal terbinafine. We conducted a head-to-head comparison of the effectiveness of the once-daily topical azole, sertaconazole, with terbinafine in these infections. We conducted a randomized, observer-blind, parallel group study (Clinical Trial Registry India [CTRI]/2014/09/005029) with adult patients of either sex presenting with localized lesions. The clinical diagnosis was confirmed by potassium hydroxide smear microscopy of skin scrapings. After baseline assessment of erythema, scaling, and pruritus, patients applied either of the two study drugs once daily for 2 weeks. If clinical cure was not seen at 2 weeks, but improvement was noted, application was continued for further 2 weeks. Patients deemed to be clinical failure at 2 weeks were switched to oral antifungals. Overall 88 patients on sertaconazole and 91 on terbinafine were analyzed. At 2 weeks, the clinical cure rates were comparable at 77.27% (95% confidence interval [CI]: 68.52%-86.03%) for sertaconazole and 73.63% (95% CI 64.57%-82.68%) for terbinafine ( P = 0.606). Fourteen patients in either group improved and on further treatment showed complete healing by another 2 weeks. The final cure rate at 4 weeks was also comparable at 93.18% (95% CI 88.75%-97.62%) and 89.01% (95% CI 82.59%-95.44%), respectively ( P = 0.914). At 2 weeks, 6 (6.82%) sertaconazole and 10 (10.99%) terbinafine recipients were considered as "clinical failure." Tolerability of both preparations was excellent. Despite the limitations of an observer-blind study without microbiological support, the results suggest that once-daily topical sertaconazole is as effective as terbinafine in localized tinea infections.

  1. Planning for transit-supportive development : a practitioner's guide. Section 2 : general transit-supportive development planning topics.

    Science.gov (United States)

    2014-06-01

    Planning for Transit-Supportive Development: A Practitioners Guide is a toolkit of practical and innovative measures to help : Metropolitan Planning Organizations (MPOs), regional planners, transit agencies, and local government elected o...

  2. Systematic Planning of Globalizing Local Firms (SPG

    Directory of Open Access Journals (Sweden)

    Hakan BÜTÜNER

    2017-03-01

    Full Text Available Globalization is the growing integration of economies and societies around the world. It is the process of interaction and integration among people, companies, and governments from different countries through international trade and investment. It allows a country to perform international trade and business to enjoy the expansion of market and trade links between various countries around the globe. The key issue for a local company in penetrating and enjoying maximum revenue in a host country is identified as studying the differences in political, economic, cultural, and business ethics between the home and host countries. The world consists of various dimensions of differences, and it is the organization’s responsibility to identify and understand them and match them with its vision. This paper outlines a systematic planning methodology for helping local businesses, which in some way have the potential to grow in the international market but feel insecure regarding the risks and threats involved, to grow globally, and will further create a sense of motivation and ambition. In here, we try to solve their issues using a systematic procedure by passing through six steps (orientation and collect key data, clarify vision, clarify environment and relate to vision, develop penetration plans, evaluate and accept the best plan, implementation and considering three fundamentals (vision, environmental analysis, and penetration strategy to further enhance their horizons with the relevant knowledge. Our main objective here is to boost the confidence of the local companies by introducing a systematic planning tool that they can use which helps them to give the chance to become global and compete in the international market.

  3. Implementation of local climate action plans

    DEFF Research Database (Denmark)

    Damsø, Tue Noa Jacques; Kjær, Tyge; Christensen, Thomas Budde

    2017-01-01

    The purpose of this article is to improve understanding of local climate action plans and their implementation and evaluation. It explores how goal definition and the choice of assessment metrics frame goal attainment and influence implementation behaviour. Using the Danish capital of Copenhagen...... a high overall implementation performance, both in terms of changes in energy supply and emission reductions, these metrics are only partially linked. It also shows that inconsistencies between the system scope of the base year emissions and goal attainment, due to the use of offsetting, may lead...

  4. 44 CFR 201.6 - Local Mitigation Plans.

    Science.gov (United States)

    2010-10-01

    ..., require a local mitigation plan for the Repetitive Flood Claims Program. A local government must have a... eligible for FMA project grants. However, these plans must be clearly identified as being flood mitigation... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Local Mitigation Plans. 201.6...

  5. Community Participation and Local Government Planning in Lesotho

    African Journals Online (AJOL)

    and planning, and promulgated it in 2001. This paper provides a critical appraisal of efforts to put local government planning into practice in Lesotho through the use of the 'Quick and SMART' local government planning model. This article uses the SWOT analysis technique to undertake a critical appraisal of this planning ...

  6. Evaluating California local land use plan's environmental impact reports

    International Nuclear Information System (INIS)

    Tang Zhenghong; Bright, Elise; Brody, Samuel

    2009-01-01

    Local land use planning has profound impacts on environmental quality; however, few empirical studies have been conducted to systematically measure local land use plans' environmental assessment quality and to identify the factors influencing it. This paper analyzes the quality of 40 Environmental Impact Reports (EIRs) of local jurisdictions' land use plans in California. A plan evaluation protocol defined by five core components and sixty-three indicators is developed to measure the quality of local land use plans' EIRs. The descriptive results indicate that the local jurisdictions produce relatively good quality on its EIRs, but there is still much room for improvement. There are large variations in the quality of EIRs across local jurisdictions. The regression results further highlight three major factors that can significantly influence local land use plan's EIR quality: number of planners, plan updating ability, and development pressure

  7. Planning Workshop on Local Level Poverty Monitoring System

    International Development Research Centre (IDRC) Digital Library (Canada)

    Md. Abdul Quader - Ranjan Kumar Guha

    decision making and incorporate these in preparing the development plans and programmes of the ... and highlight the usefulness of the information in local level planning. The aim ..... proper accounts of the cooperatives for its sustainability.

  8. Topical amethocaine (Ametop) is superior to EMLA for intravenous cannulation. Eutectic mixture of local anesthetics.

    LENUS (Irish Health Repository)

    Browne, J

    2012-02-03

    PURPOSE: A eutectic mixture of local anesthetics (EMLA) is commonly used to provide topical anesthesia for intravenous (i.v.) cannulation. One of its side effects is vasoconstriction, which may render cannulation more difficult. A gel formulation of amethocaine (Ametop) is now commercially available. The aim of this study was to compare EMLA and Ametop with regard to the degree of topical anesthesia afforded, the incidence of vasoconstriction and the ease of i.v. cannulation. METHODS: Thirty two ASA I adult volunteers had a #16 gauge i.v. cannula inserted on two separate occasions using EMLA and Ametop applied in a double blind fashion for topical anesthesia. Parameters that were recorded after each cannulation included visual analogue pain scores (VAPS), the presence of vasoconstriction and the ease of cannulation, graded as: 1 = easy, 2 = moderately difficult, 3 = difficult and 4 = failed. RESULTS: The mean VAPS +\\/- SD after cannulation with Ametop M was 12+\\/-9.9 and with EMLA was 25.3+\\/-16.6 (P = 0.002). Vasoconstriction occurred after EMLA application on 17 occasions and twice after Ametop (P = 0.001). The grade of difficulty of cannulation was 1.44+\\/-0.88 following EMLA and 1.06+\\/-0.25 with Ametop (P = 0.023). CONCLUSIONS: Intravenous cannulation was less painful following application of Ametop than EMLA. In addition, Ametop caused less vasoconstriction and facilitated easier cannulation. Its use as a topical anesthetic agent is recommended, especially when i.v. access may be problematic.

  9. Development of Lesson Plans and Student Worksheets Based Socio-Scientific Issues on Pollution Environmental Topic

    Science.gov (United States)

    Rahayu, S.; Meyliana, M.; Arlingga, A.; Reny, R.; Siahaan, P.; Hernani, H.

    2017-09-01

    The aim of this study is to develop lesson plans and student worksheets based socio-scientific issues on pollution environmental topic for seventh-grade junior high school students. Environmental pollution topic split into several subtopics namely air pollution, water pollution and soil pollution. The composing of lesson plans were developed based on socio-scientific issues with five stages, namely (1) Motivate; (2) Challenge; (3) Collect scientific evidence; (4) Analyse the evidence; (5) Build knowledge and make connections; and (6) Use evidence. While student worksheets contain articles on socio-scientific issues, practice, and there are a few questions to determine students’ reasoning. The method that is used in this research is research and development (R & D method). Development model used in this study is a model of Plomp that consists of four stages, namely: (1) Initial Research; (2) Design; (3) Realization or Construction; (4) Testing, evaluation and revision; (5) Implementation, while the research was limited to the fourth stage. Lesson plans and student worksheets based on socio-scientific issues was validated through an expert validation. The result showed that lesson plans and student worksheets based socio-scientific issues on pollution theme have a very decent and be able to apply in science classroom.

  10. Revealing the Structural Complexity of Component Interactions of Topic-Specific PCK when Planning to Teach

    Science.gov (United States)

    Mavhunga, Elizabeth

    2018-04-01

    Teaching pedagogical content knowledge (PCK) at a topic-specific level requires clarity on the content-specific nature of the components employed, as well as the specific features that bring about the desirable depth in teacher explanations. Such understanding is often hazy; yet, it influences the nature of teacher tasks and learning opportunities afforded to pre-service teachers in a teaching program. The purpose of this study was twofold: firstly, to illuminate the emerging complexity when content-specific components of PCK interact when planning to teach a chemistry topic; and secondly, to identify the kinds of teacher tasks that promote the emergence of such complexity. Data collected were content representations (CoRes) in chemical equilibrium accompanied by expanded lesson outlines from 15 pre-service teachers in their final year of study towards a first degree in teaching (B Ed). The analysis involved extraction of episodes that exhibited component interaction by using a qualitative in-depth analysis method. The results revealed the structure in which the components of PCK in a topic interact among each other to be linear, interwoven, or a combination of the two. The interwoven interactions contained multiple components that connected explanations on different aspects of a concept, all working in a complementary manner. The most sophisticated component interactions emerged from teacher tasks on descriptions of a lesson sequence and a summary of a lesson. Recommendations in this study highlight core practices for making pedagogical transformation of topic content knowledge more accessible.

  11. The Local Agenda 21 Planning Guide: An Introduction to ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Local Agenda 21 Planning Guide is an introductory guide on the planning elements, methods, and tools being used by local governments to implement Agenda ... International Water Resources Association, in close collaboration with IDRC, is holding a webinar titled “Climate change and adaptive water management: ...

  12. Transformation of topic-specific professional knowledge into personal pedagogical content knowledge through lesson planning

    Science.gov (United States)

    Stender, Anita; Brückmann, Maja; Neumann, Knut

    2017-08-01

    This study investigates the relationship between two different types of pedagogical content knowledge (PCK): the topic-specific professional knowledge (TSPK) and practical routines, so-called teaching scripts. Based on the Transformation Model of Lesson Planning, we assume that teaching scripts originate from a transformation of TSPK during lesson planning: When planning lessons, teachers use their TSPK to create lesson plans. The implementation of these lesson plans and teachers' reflection upon them lead to their improvement. Gradually, successful lesson plans are mentally stored as teaching scripts and can easily be retrieved during instruction. This process is affected by teacher's beliefs, motivation and self-regulation. In order to examine the influence of TSPK on teaching scripts as well as the moderating effects of beliefs, motivation and self-regulation, we conducted a cross-sectional study with n = 49 in-service teachers in physics. The TSPK, beliefs, motivation, self-regulation and the quality of teaching scripts of in-service teachers were assessed by using an online questionnaire adapted to teaching the force concept and Newton's law for 9th grade instruction. Based on the measurement of the quality of teaching scripts, the results provide evidence that TSPK influences the quality of teaching scripts. Motivation and self-regulation moderate this influence.

  13. An expert system for a local planning environment

    NARCIS (Netherlands)

    Meester, G.J.; Meester, G.J.

    1993-01-01

    In this paper, we discuss the design of an Expert System (ES) that supports decision making in a Local Planning System (LPS) environment. The LPS provides the link between a high level factory planning system (rough cut capacity planning and material coordination) and the actual execution of jobs on

  14. Local Option Taxes and the New Subregionalism in Transportation Planning

    OpenAIRE

    Goldman, Todd Mitchel

    2005-01-01

    This dissertation examines the planning processes for new local option transportation taxes. Typically, these are temporary, voter-approved, single-county sales taxes linked to legally binding expenditure plans. In many states, they increasingly dominate transportation planning and finance. Because they bypass the federally-mandated metropolitan planning process, they appear to place at risk important policy goals (e.g. reducing air pollution) that it is intended to address. Yet they can also...

  15. Topical anesthesia with eutetic mixture of local anesthetics cream in vasectomy: 2 randomized trials

    DEFF Research Database (Denmark)

    Honnens de Lichtenberg, M; Krogh, J; Rye, B

    1992-01-01

    Two paired randomized trials testing topical anesthesia with a eutetic mixture of local anesthetics (EMLA cream*) in vasectomy were performed. In 1 trial EMLA cream was applied on 1 side of the scrotum, while infiltration anesthesia into the skin and subcutaneous tissue with mepivacaine was used...... on the contralateral side. All but 1 of the 13 patients (p less than 0.05) preferred infiltration anesthesia because of pain as the incision reached the subcutaneous tissue. In the other trial 29 patients received EMLA cream on 1 side of the scrotum before bilateral mepivacaine infiltration. There was significantly...... less pain on the sides with the anesthetic cream (p less than 0.001). Many patients would pay the price of the cream. In conclusion, EMLA cream cannot replace but it can supplement infiltration anesthesia during vasectomy....

  16. 2: Local area networks as a multiprocessor treatment planning system

    International Nuclear Information System (INIS)

    Neblett, D.L.; Hogan, S.E.

    1987-01-01

    The creation of a local area network (LAN) of interconnected computers provides an environment of multi computer processors that adds a new dimension to treatment planning. A LAN system provides the opportunity to have two or more computers working on the plan in parallel. With high speed interprocessor transfer, events such as the time consuming task of correcting several individual beams for contours and inhomogeneities can be performed simultaneously; thus, effectively creating a parallel multiprocessor treatment planning system

  17. ANS [American Nuclear Society] topical meeting on radiological accidents: Perspectives and emergency planning: Proceedings

    International Nuclear Information System (INIS)

    1987-03-01

    The increasing use of radioactive materials and the increasing public concern about possible accidents involving these materials has led to greater emphasis on preparing for such emergencies. The ANS Topical Meeting on Radiological Accidents - Perspectives and Emergency Planning provided a review of experiences with radiological accidents. The meeting covered some of the most important aspects of radiological accidents. Papers were presented which dealt with radiological accident experience. Technical response to accidents is of primary interest to many in the nuclear community; most of the papers submitted fell into this area. So many of these papers dealt with the use of computers in response that a session on that topic was arranged. A very significant impact of most radiological accidents is the cost, especially the cost of cleanup. There were papers on what is known about costs and associated current topics, such as modification and extension of the Price-Anderson Act. At least as important as the technical response to accidents is how society attempts to deal with them. A session on institutional issues was included to discuss how governments and other organizations respond to and deal with accidents. Medical effects of accidents are of great concern to the public. Invited papers to review the effects of high doses of radiation as well as very low doses were included in that session. Although the nuclear industry has an excellent safety record, this fact often does not agree with the public perception of the industry. The final session explored the public response to and perception of radiological emergencies and accidents. This subject will ultimately determine the future use of radioactive materials in this country

  18. Local Authorities Participation in the Tourism Planning Process

    Directory of Open Access Journals (Sweden)

    Ali SELCUK CAN

    2014-02-01

    Full Text Available The aim of this article is to explore the weaknesses and strengths of local authorities in terms of their participation in the tourism planning process in Turkey. A two-page questionnaire was applied, along with structured interviews with 71 administrators of metropolitan, provincial, and district authorities, between January 1 and September 31, 2011. The findings of the survey suggest that tourism planning responsibilities should be devolved to local authorities. Local authorities do not extensively participate in tourism planning at present because of inadequate budgeting and tourism allocation facilities, insufficient cooperation among stakeholders, and a domination of central administration traditions. Causes of insufficient participation in tourism planning statistically differ among local authorities, in terms of insufficient realizations of the importance of tourism planning by stakeholders, and public land allocation for the purpose of tourism. On the other hand, there is a statistically significant difference between local authorities that have a tourism master plan and those who do not, in terms of a lack of educational opportunities for planners.

  19. Strategic plans for designing information systems under local government

    OpenAIRE

    Raman Nair, R.

    1998-01-01

    In decentralized administration local bodies are concerned with various administrative, educational and development issues. So in local government the planning for use of technology have started to recognize the value of information. This study attempts to evolve technical guidelines for building up an information system under local government that has to provide networking services by connecting various offices and institutions like Block Panchayat Office, Village Panchayat Office, District...

  20. [Local planning: the speech of basic health care center manager].

    Science.gov (United States)

    Cubas, Márcia Regina

    2005-01-01

    As planning is understood as a management tool, this article offers an argument through the speech framework of Basic Health Care Center Managers in the city of Curitiba-PR, by means of the Collective Subject Speech Methodology on local planning aspects. Its purpose is to bring local managers to a reflection concerning their styles, practices and experiences, as well as to collaborate with central level leading teams towards building their planning processes in an upward, participatory, communicative and strategic way. Considerations of the speeches built from central ideas are presented: planning methodology; inter-sectoriality; territorial basis; team and community participation; training, autonomy and particular profile of local managers; the manager's agenda; and institutional culture.

  1. The topical 5% lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence

    Directory of Open Access Journals (Sweden)

    de León-Casasola OA

    2016-02-01

    Full Text Available Oscar A de León-Casasola,1,2 Victor Mayoral3 1Department of Anesthesiology, Division of Pain Medicine, Roswell Park Cancer Institute, 2University at Buffalo, School of Medicine and Biomedical Sciences. NY, USA; 3Anesthesiology Department, Pain Management Unit, University Hospital of Bellvitge, L'Hospitalet de Llobregat, Spain Abstract: Topical 5% lidocaine medicated plasters represent a well-established first-line option for the treatment of peripheral localized neuropathic pain (LNP. This review provides an updated overview of the clinical evidence (randomized, controlled, and open-label clinical studies, real-life daily clinical practice, and case series. The 5% lidocaine medicated plaster effectively provides pain relief in postherpetic neuralgia, and data from a large open-label controlled study indicate that the 5% lidocaine medicated plaster is as effective as systemic pregabalin in postherpetic neuralgia and painful diabetic polyneuropathy but with an improved tolerability profile. Additionally, improved analgesia and fewer side effects were experienced by patients treated synchronously with the 5% lidocaine medicated plaster, further demonstrating the value of multimodal analgesia in LNP. The 5% lidocaine medicated plaster provides continued benefit after long-term (≤7 years use and is also effective in various other LNP conditions. Minor application-site reactions are the most common adverse events associated with the 5% lidocaine medicated plaster; there is minimal risk of systemic adverse events and drug–drug interactions. Although further well-controlled studies are warranted, the 5% lidocaine medicated plaster is efficacious and safe in LNP and may have particular clinical benefit in elderly and/or medically compromised patients because of the low incidence of adverse events. Keywords: 5% lidocaine medicated plaster, clinical evidence, localized neuropathic pain, postherpetic neuralgia, review

  2. The Toggle Local Planner for sampling-based motion planning

    KAUST Repository

    Denny, Jory

    2012-05-01

    Sampling-based solutions to the motion planning problem, such as the probabilistic roadmap method (PRM), have become commonplace in robotics applications. These solutions are the norm as the dimensionality of the planning space grows, i.e., d > 5. An important primitive of these methods is the local planner, which is used for validation of simple paths between two configurations. The most common is the straight-line local planner which interpolates along the straight line between the two configurations. In this paper, we introduce a new local planner, Toggle Local Planner (Toggle LP), which extends local planning to a two-dimensional subspace of the overall planning space. If no path exists between the two configurations in the subspace, then Toggle LP is guaranteed to correctly return false. Intuitively, more connections could be found by Toggle LP than by the straight-line planner, resulting in better connected roadmaps. As shown in our results, this is the case, and additionally, the extra cost, in terms of time or storage, for Toggle LP is minimal. Additionally, our experimental analysis of the planner shows the benefit for a wide array of robots, with DOF as high as 70. © 2012 IEEE.

  3. Developing local scenarios to nitrogen management using participatory planning

    DEFF Research Database (Denmark)

    Piil, Kristoffer; Wiborg, Irene; Andersen, Peter Stubkjær

    2017-01-01

    incurred significant financial burdens on farmers, as well as restricting their freedom of operation on their farms. Over the last years, there has been a shift towards a targeted regulation that takes local conditions into account, in order to increase the cost effectiveness of mitigation strategies...... to be taken into account when involving a community in participatory planning regarding nitrogen management. As part of a more targeted Danish regulation, a system of catchment officers is currently being established to aide in formulating mitigation strategies that are adapted to local needs and local...

  4. Barriers in Local Climate Change Adaptation Planning in Nepal

    Czech Academy of Sciences Publication Activity Database

    Dhungana, N.; Chiranjeewee, Khadka; Bhatta, B. P.; Regmi, S.

    2017-01-01

    Roč. 62, jun (2017), s. 20-24 ISSN 2224-3240 Institutional support: RVO:67179843 Keywords : Local Adaptation Plan for Action Framework * Barriers * Climate Change Adaptation * Village Development Committees Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7) http://www.iiste.org/Journals/index.php/JLPG/article/view/37535

  5. The relationship between the Municipal Master Plan and local Watershed Plans in water management

    Directory of Open Access Journals (Sweden)

    Denise Gallo Pizella

    2015-07-01

    Full Text Available The National Water Resources Policy has as one of its tools the drafting of local Water Resource Plans. In view of water resources planning and its relationship to land use planning, the aim of this work is to analyze the institutional and legal difficulties and the potential for an integrated system of water resources management. For this, we used the method of documentary and bibliographic research, beginning with the “Estatuto da Cidade”, a law for urban policy in Brazil, and literature on water management at the municipal and watershed levels. At the municipal level, the “Master Plan” (municipal plan of land use planning became the main instrument of territorial and municipal management, defining the parameters for the compliance of social, environmental and economic functions of real property. In this sense, the municipalities have a responsibility to protect water resources and, without local support, territorial and water management cannot be integrated in the context of the river basin. Despite the difficulties of including environmental variable in urban planning, the Master Plan has the potential to shape local water management systems that are environmentally sustainable and that progressively improve water quality and quantity within the watershed. Similarly, with more significant participation of the municipality in the Basin Committee, it is possible that the forms of municipal land use and occupation can be considered during the development and implementation of the Basin Plan. Thus, the management of water resources can occur integrally.

  6. Plan de marketing para locales de venta de carne porcina

    OpenAIRE

    Córdoba, Federico Nicolás

    2016-01-01

    Tesis (maestría en dirección de negocios) -- Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina, 2016 El presente documento tomará como referencia para la elaboración de un Plan de Marketing para la implementación de productos pre-elaborados en los locales pertenecientes a la empresa Cerdo de los Llanos S.A.P.E.M., radicada en la provincia de La Rioja, Argentina. Instalada ya desde el año 2012 como una de las mayores apuestas productivas de un Plan Económico Provin...

  7. Women in water management: the need for local planning.

    Science.gov (United States)

    Bhatt, M R

    1995-08-01

    This article on women's role in water resource management is based on a paper delivered at a seminar organized at the Water and Land Management Institute in Anand, India, in 1994. The article reflects Family Planning International's (FPI) experience in community-based water resource development. Most analyses of village and household water management data exclude women's role. The reasons are identified as the lack of inclusion of women's thinking in land-development research and planning, the dominance of males in planning and consequent male assumptions made about women's work and use of water, the lack of valuation of the nonmonetary nature of women's relationship to water, and the ease of ignoring women. Women's roles that are obstacles to inclusion in research and planning are identified as the lack of effective women's lobbies, the undervaluation by women of their work, and the lack of professional recognition of women as potential users of water or spokespersons for more than their own self-interests as women. National water policies are shifting to community-based management because local authorities are in daily contact with users, of whom about 50% are women. Historically national policy shifted from attention to distribution of investments in the water sector to reorganization of water agencies and to building up the capacity of private or voluntary agencies. The local context allows for more efficient and effective responses to local conditions. Local institutions and groups are better equipped to solicit local participation. One primary lesson learned by FPI is that local water resource planning is very important in strengthening the economic and individual capacity of poor people in underdeveloped areas. FPI's experience in Mahesana, Banaskantha, and Sabarkantha in Gujarat state supports this lesson learned. Water resource development policies resulted in mixed outcomes, and national control has been inefficient and disrespectful to local authorities

  8. A knowledge representation of local pandemic influenza planning models.

    Science.gov (United States)

    Islam, Runa; Brandeau, Margaret L; Das, Amar K

    2007-10-11

    Planning for pandemic flu outbreak at the small-government level can be aided through the use of mathematical policy models. Formulating and analyzing policy models, however, can be a time- and expertise-expensive process. We believe that a knowledge-based system for facilitating the instantiation of locale- and problem-specific policy models can reduce some of these costs. In this work, we present the ontology we have developed for pandemic influenza policy models.

  9. A New Method for Local Energy Planning in Developing Countries

    International Nuclear Information System (INIS)

    Van Beeck, N.

    2001-01-01

    Energy planning is an essential tool in the economic development of industrialized as well as developing countries. Energy planning in this paper is restricted to the selection of new energy systems for the production of proper energy forms in order to meet increased energy demand. This demand is actually the desire for certain energy services, which are the starting point of the new decision support method for local energy planning presented in this paper. In the decision making process concerning energy planning at the local level it is important to include context-related issues because the context determines for a large part the viability of the technologies or systems used. The context, in turn, is represented by the aims of the relevant actors, which are translated into measurable indicators to compare the different options. The impact assessment must allow for inclusion of all the indicators, either quantitative or qualitative in order to find the most appropriate technology for a region rather than the technically best or economically most optimal one. Appropriateness is defined by the context and is thus case specific, but the framework described in this paper is generally applicable within the given limitations. Note that the new method described in this paper is a decision support tool, implying that it does not decide for the energy planner which actions to take. The ultimate decision must be made by the planners themselves

  10. Plaque-Like Sclerodermiform Localized Mucinosis Rapidly Responsive to Topical Tacrolimus

    Directory of Open Access Journals (Sweden)

    R. Schmaltz

    2010-08-01

    Full Text Available We report the successful treatment of plaque-like sclerodermiform mucinosis using tacrolimus ointment topically. We present a 70-year-old male with a large chronic erythema and hardening of the nuchal skin and shoulder area. Subjective symptoms were a moderate pruritus and a rather disabling stiffness. A biopsy specimen revealed typical features of lichen myxedematosus. In a subsequent clinical examination, no associated illnesses such as hypothyroidism or gammopathy were found. Since no established therapy exists for this condition, and as there was a lack of response to potent topical glucocorticosteroids, tacrolimus 0.03% ointment was used off-label twice daily. Surprisingly, this resulted in a rapid, almost complete clearance of the skin within three weeks of treatment.

  11. Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin.

    Science.gov (United States)

    Brown, M B; Jones, S A

    2005-05-01

    Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is present in the intercellular matrix of most vertebrate connective tissues especially skin where it has a protective, structure stabilizing and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications, which include: the supplementation of joint fluid in arthritis; as a surgical aid in eye surgery; and to facilitate the healing and regeneration of surgical wounds. More recently, HA has been investigated as a drug delivery agent for various routes of administration, including ophthalmic, nasal, pulmonary, parenteral and topical. In fact, regulatory approval in the USA, Canada and Europe was granted recently for 3% diclofenac in 2.5% HA gel, Solaraze, for the topical treatment of actinic keratoses, which is the third most common skin complaint in the USA. The gel is well tolerated, safe and efficacious and provides an attractive, cost-effective alternative to cryoablation, curettage or dermabrasion, or treatment with 5-fluorouracil. The purpose of this review is to describe briefly the physical, chemical and biological properties of HA together with some details of its medical and pharmaceutical uses with emphasis on this more recent topical application.

  12. Contraceptive security, information flow, and local adaptations: family planning Morocco.

    Science.gov (United States)

    Chandani, Y; Breton, G

    2001-12-01

    Many developing countries increasingly recognize and acknowledge family planning as a critical part of socio-economic development. However, with few health dollars to go around, countries tend to provide essential drugs for curative care, rather than for family planning products. Donors have historically provided free contraceptives for family planning services. Whether products are donated or purchased by the country, a successful family planning program depends on an uninterrupted supply of products, beginning with the manufacturer and ending with the customer. Any break in the supply chain may cause a family planning program to fail. A well-functioning logistics system can manage the supply chain and ensure that the customers have the products they need, when they need them. Morocco was selected for the case study. The researchers had ready access to key informants and information about the Logistics Management Information System. Because the study had time and resource constraints, research included desktop reviews and interview, rather than data collection in the field. The case study showed that even in a challenging environment an LMIS can be successfully deployed and fully supported by the users. It is critical to customize the system to a country-specific situation to ensure buy-in for the implementation. Significant external support funding and technical expertise are critical components to ensure the initial success of the system. Nonetheless, evidence from the case study shows that, after a system has been implemented, the benefits may not ensure its institutionalization. Other support, including local funding and technical expertise, is required.

  13. Community energy and emissions planning : a guide for BC local governments

    International Nuclear Information System (INIS)

    2008-09-01

    British Columbia (BC) local governments are becoming more interested in completing an energy and greenhouse gas emissions plan for their community as awareness of climate change grows and energy prices escalate. The purpose of this guide was to support local government elected officials and staff in undertaking an energy and emissions planning process. This guide described the purpose and content of a community energy and emissions plan, its benefits, and how to go about creating one. Specifically, the guide provided practical tips, examples from BC communities, and links to more detailed information. Topics that were presented in the guide included engagement; inventories; target-setting; action plan; implementation and monitoring; and funding and resources. It was concluded that the key to long-term success is to maintain good communication with council/board, staff and the public. The document emphasized that it is important to make sure that people know the work being undertaken, and the results achieved, so that momentum is not lost. refs., tabs., figs

  14. Topical tacrolimus and periodontal therapy in the management of a case of oral chronic GVHD characterized by specific gingival localization.

    Science.gov (United States)

    Conrotto, Davide; Broccoletti, Roberto; Carcieri, Paola; Giaccone, Luisa; Arduino, Paolo G

    2014-01-01

    Background. Chronic graft versus host disease (cGVHD) is a complication following bone marrow transplantation. The oral lesions are difficult to control with a systemic pharmacological therapy. Case Description. A 63-year-old female patient, who underwent an allogeniec transplantation for acute myeloid leukemia, developed a chronic oral and cutaneous GVHD. The patient was treated with topical tacrolimus 0.1%, twice daily for two months, and underwent a protocol of oral hygiene characterized by 3 appointments of scaling, root planning, and daily oral hygiene instructions. The patient showed marked resolution of gingival lesions and a significant improvement of related pain and gingival inflammatory indexes. Clinical Implications. This case report suggests that treatment with topical tacrolimus and professional oral hygiene may be helpful in the management of chronic oral GVHD with severe gingival involvement.

  15. Topical Tacrolimus and Periodontal Therapy in the Management of a Case of Oral Chronic GVHD Characterized by Specific Gingival Localization

    Directory of Open Access Journals (Sweden)

    Davide Conrotto

    2014-01-01

    Full Text Available Background. Chronic graft versus host disease (cGVHD is a complication following bone marrow transplantation. The oral lesions are difficult to control with a systemic pharmacological therapy. Case Description. A 63-year-old female patient, who underwent an allogeniec transplantation for acute myeloid leukemia, developed a chronic oral and cutaneous GVHD. The patient was treated with topical tacrolimus 0.1%, twice daily for two months, and underwent a protocol of oral hygiene characterized by 3 appointments of scaling, root planning, and daily oral hygiene instructions. The patient showed marked resolution of gingival lesions and a significant improvement of related pain and gingival inflammatory indexes. Clinical Implications. This case report suggests that treatment with topical tacrolimus and professional oral hygiene may be helpful in the management of chronic oral GVHD with severe gingival involvement.

  16. Project plan remove special nuclear material from PFP project plutonium finishing plant; TOPICAL

    International Nuclear Information System (INIS)

    BARTLETT, W.D.

    1999-01-01

    This plan presents the overall objectives, description, justification and planning for the Plutonium Finishing Plant (PFP) Remove Special Nuclear Material (SNM) Materials. The intent of this plan is to describe how this project will be managed and integrated with other facility stabilization and deactivation activities. This plan supplements the overall integrated plan presented in the Plutonium Finishing Plant Integrated Project Management Plan (IPMP), HNF-3617,Rev. 0. This project plan is the top-level definitive project management document for PFP Remove SNM Materials project. It specifies the technical, schedule, requirements and the cost baselines to manage the execution of the Remove SNM Materials project. Any deviations to the document must be authorized through the appropriate change control process

  17. A compilation of necessary elements for a local government continuity of operations plan

    OpenAIRE

    Cashen, Kevin M.

    2006-01-01

    CHDS State/Local National and state homeland security strategies call for continuity of operations plan development. The 2006 Nationwide Plan Review Phase II Report identifies continuity of operations plan development as a state and local goal with a federal goal of providing continuity of operations plan development support. Most local governments do not have a continuity of operation plan or it needs to be updated. Continuity of operations plan guidance is provided by a variety of intern...

  18. PLUS: 'Planning Land Use with Students' is a Local Land Use Policy That Showcase the Geosciences

    Science.gov (United States)

    Turrin, M.

    2014-12-01

    Land Use decisions in the local community are well represented in geoscience topics and issues, and provide an excellent opportunity to showcase a wide range of geoscience careers to high school students. In PLUS (Planning Land Use with Students) we work with youth corps, volunteer agencies and the County Departments of Planning, Transportation, Public Health, Water Resources to run a program for high school seniors to engage the students in the complex layers of decision making connected with land use as we showcase geoscience careers (http://www.ldeo.columbia.edu/edu/plus/index.html). How development occurs, what resources are in use and who makes these decisions is both interesting and relevant for students. We develop case studies around current, active, local land use issues large enough in scale to have a formal environmental review at the County and/or the State level. Sections of each case study are dedicated to addressing the range of environmental issues that are central to each land use decision. Water, its availability, planned use and treatment on the site, brings in both a review of local hydrology and a discussion of storm water management. Air quality and the impact of the proposed project's density, transportation plans, and commercial and industrial uses brings in air quality issues like air quality ratings, existing pollution, and local air monitoring. A review of the site plans brings in grading plans for the project area, which highlights issues of drainage, soil stability, and exposure to toxins or pollutants depending on the historic use of the site. Brownfield redevelopments are especially challenging with various monitoring, clean up and usage restrictions that are extremely interesting to the students. Students' work with mentors from the community who represent various roles in the planning process including a range of geosciences, community business members and other players in the planning process. This interplay of individuals provides

  19. Storytelling and Technology Combine to Create Student Engagement Around Locally Relevant Climate Change Topics.

    Science.gov (United States)

    Leckey, E.; Littrell-Baez, M.; Tayne, K.; Gold, A. U.; Okochi, C.; Oonk, D.; Smith, L. K.; Lynds, S. E.

    2017-12-01

    Storytelling is a powerful way for students to engage with science topics, particularly topics that may initially seem too broad to impact their lives, like climate change. Empowering students to telling a personal story about climate change's effects and helping them turn their story into a film is powerful approach. Especially because these films can be shared globally and gives students a voice around a complex topic like climate change. Here, we present impacts of the Lens on Climate Change program (LOCC), which engages middle and high school students in producing short films featuring how climate change impacts their communities. LOCC is offered as an intensive week-long summer program and as an extracurricular program during the school year. The majority of student participants are recruited from historically underserved communities and come from ethnical and socioeconomically diverse backgrounds. Survey data revealed that LOCC participants had a significant increase in their belief in the reality of climate change after participation in their program relative to students in a demographically-matched control groups. Furthermore, participant responses on reflection surveys given after the program included statements that suggest that students had begun thinking more deeply about climate change as a serious global challenge and felt empowered to take actions to mitigate climate change and/or spread awareness in their communities. The majority of students in the LOCC program also reported being very proud of their film and intended to share their film with their friends and family. Additionally, we explored the long-term impacts of participation by interviewing students a year after the program and offered them the opportunity to make a subsequent film. Students in this "advanced group" reported being more aware of climate change in their community following making their films and were enthusiastic to increase their filmmaking skills through producing additional

  20. Tuberculosis control: decentralization, local planning and management specificities.

    Science.gov (United States)

    Trigueiro, Janaína Von Söhsten; Nogueira, Jordana de Almeida; de Sá, Lenilde Duarte; Palha, Pedro Fredemir; Villa, Tereza Cristina Scatena; Trigueiro, Débora Raquel Soares Guedes

    2011-01-01

    The goal was to analyze, according to the perception of health managers, the practices that guide tuberculosis control actions in cities in the metropolitan region of João Pessoa - PB, Brazil. This qualitative study involved eight professionals in management functions. Testimonies were collected through semi-structured interviews between May and June 2009 and organized through content analysis. Despite the acknowledged benefits of tuberculosis control action decentralization, local planning indicates the predominance of a bureaucratic model that is restricted to negotiation and supplies. Local programming is centered on the coordinator, which shows a command line and vertical management that lead to the fragmentation of the work process. Management action should follow an innovative and transformative route that surpasses bureaucratic barriers and faces the biggest challenge it is proposed: to balance professional interrelations with a view to improving health work performance.

  1. Development of Consensus Treatment Plans for Juvenile Localized Scleroderma

    Science.gov (United States)

    Li, Suzanne C.; Torok, Kathryn S.; Pope, Elena; Dedeoglu, Fatma; Hong, Sandy; Jacobe, Heidi T.; Rabinovich, C. Egla; Laxer, Ronald M.; Higgins, Gloria C.; Ferguson, Polly J.; Lasky, Andrew; Baszis, Kevin; Becker, Mara; Campillo, Sarah; Cartwright, Victoria; Cidon, Michael; Inman, Christi J; Jerath, Rita; O'Neil, Kathleen M.; Vora, Sheetal; Zeft, Andrew; Wallace, Carol A.; Ilowite, Norman T.; Fuhlbrigge, Robert C

    2013-01-01

    Objective To develop standardized treatment plans, clinical assessments, and response criteria for active, moderate to high severity juvenile localized scleroderma (jLS). Background jLS is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies have been reported in the literature, a lack of agreement on treatment specifics and accepted methods for clinical assessment of have made it difficult to compare approaches and identify optimal therapy. Methods A core group of pediatric rheumatologists, dermatologists and a lay advisor was engaged by the Childhood Arthritis and Rheumatology Research Alliance (CARRA) to develop standardized treatment plans and assessment parameters for jLS using consensus methods/nominal group techniques. Recommendations were validated in two face-to-face conferences with a larger group of practitioners with expertise in jLS and with the full membership of CARRA, which encompasses the majority of pediatric rheumatologists in the U.S and Canada. Results Consensus was achieved on standardized treatment plans that reflect the prevailing treatment practices of CARRA members. Standardized clinical assessment methods and provisional treatment response criteria were also developed. Greater than 90% of pediatric rheumatologists responding to a survey (67% of CARRA membership) affirmed the final recommendations and agreed to utilize these consensus plans to treat patients with jLS. Conclusions Using consensus methodology, we have developed standardized treatment plans and assessment methods for jLS. The high level of support among pediatric rheumatologists will support future comparative effectiveness studies and enable the development of evidence-based guidelines for the treatment of jLS. PMID:22505322

  2. Tools and Processes for Handling of Transfer of Burdens, Knowledge and Responsibility: Preparing Future Generations and Empowering Local Communities. Proceedings of a Topical Session

    International Nuclear Information System (INIS)

    2008-01-01

    Radioactive waste management (RWM) is a humane activity that may span several generations in an active phase and involves a very long time in a more or less sleeping phase so it is important to find the solution adequate for the short and the very long term and to prepare next generations. The Topical Session was composed of two parts: Part A: Preparing future generations; Part B: Empowering local communities and improving decision making. Regulatory case studies were heard from Sweden and the US in the first part. In the second part, the Transparency Programme of KASAM (Sweden) was presented. The present report documents the topical session. Its summary and lessons learnt capture both the oral presentations and the discussions that took place in the audience. The experiences reported suggest that the following issues are important for radioactive waste management: -) Careful consideration of impacts on future generations including the opportunities and burdens we pass on to them; -) Forward planning to enable long-term issues to be adequately addressed, on technical, regulatory, financial and societal aspects; -) Listening to and involving communities who live close to facilities; -) Recognising that communities feel more confident if they are part of the discussions about the long-term implications of RWM and that they want to be involved in the discussions and the plans; -) Exploring the long-term role of local communities and how this should be supported; -) Recognising our own limitations and putting in place mechanisms to deal with these; -) Ensuring transparency throughout the process; and -) Developing clear roles and responsibilities in the short and long term

  3. Local health care expenditure plans and their opportunity costs.

    Science.gov (United States)

    Karlsberg Schaffer, Sarah; Sussex, Jon; Devlin, Nancy; Walker, Andrew

    2015-09-01

    In the UK, approval decisions by Health Technology Assessment bodies are made using a cost per quality-adjusted life year (QALY) threshold, the value of which is based on little empirical evidence. We test the feasibility of estimating the "true" value of the threshold in NHS Scotland using information on marginal services (those planned to receive significant (dis)investment). We also explore how the NHS makes spending decisions and the role of cost per QALY evidence in this process. We identify marginal services using NHS Board-level responses to the 2012/13 Budget Scrutiny issued by the Scottish Government, supplemented with information on prioritisation processes derived from interviews with Finance Directors. We search the literature for cost-effectiveness evidence relating to marginal services. The cost-effectiveness estimates of marginal services vary hugely and thus it was not possible to obtain a reliable estimate of the threshold. This is unsurprising given the finding that cost-effectiveness evidence is rarely used to justify expenditure plans, which are driven by a range of other factors. Our results highlight the differences in objectives between HTA bodies and local health service decision makers. We also demonstrate that, even if it were desirable, the use of cost-effectiveness evidence at local level would be highly challenging without extensive investment in health economics resources. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. The Effect of Topical Local Anesthetics on Thermal Pain Sensitivity in Patients with Irritable Bowel Syndrome

    Directory of Open Access Journals (Sweden)

    Anthony Rodrigues

    2012-01-01

    Full Text Available Generalized hypersensitivity that extends into somatic areas is common in patients with irritable bowel syndrome (IBS. The sensitized state, particularly assessed by experimental methods, is known to persist even during remissions of clinical pain. It was hypothesized that disease-related nociceptive activity in the gut maintains a systemic-sensitized state. The present study evaluated responses to prolonged thermal stimuli maintained at constant temperature or constant pain intensity during stimulation. The effect of topically applied rectal lidocaine on heat sensitivity was also evaluated. The question is whether silencing potential intestinal neural activity (which may not always lead to a conscious pain experience with lidocaine attenuates sensitization of somatic areas. Tests were also performed where lidocaine was applied orally to control for systemic or placebo effects of the drug. The IBS subjects exhibited a greater sensitivity to somatic heat stimuli compared to controls; however, lidocaine had no discernible effect on sensitization in this sample of IBS patients, where most of the individuals did not have clinical pain on the day of testing.

  5. Planning for transit-supportive development : a practitioner's guide. Section 5 : local planning and transit-supportive development.

    Science.gov (United States)

    2014-06-01

    Planning for Transit-Supportive Development: A Practitioners Guide is a toolkit of practical and innovative measures to help : Metropolitan Planning Organizations (MPOs), regional planners, transit agencies, and local government elected o...

  6. Local Government GIS and Geospatial Capabilities : Suitability for Integrated Transportation & Land Use Planning (California SB 375)

    Science.gov (United States)

    2009-11-01

    This report examines two linked phenomena in transportation planning: the geospatial analysis capabilities of local planning agencies and the increasing demands on such capabilities imposed by comprehensive planning mandates.

  7. Site scientific mission plan for the southern great plains CART site January-June 2000.; TOPICAL

    International Nuclear Information System (INIS)

    Peppler, R. A.; Sisterson, D. L.; Lamb, P.

    2001-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site was designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This Site Scientific Mission Plan defines the scientific priorities for site activities during the six months beginning on January 1, 2000, and looks forward in less detail to subsequent six-month periods. The primary purpose of this document is to provide scientific guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team[DSIT], Operations Team, and Instrument Team[IT]) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the site program manager, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding. With this issue, many aspects of earlier Site Scientific Mission Plan reports have been moved to ARM sites on the World Wide Web. This report and all previous reports are available on the SGP CART web site

  8. Tank monitor and control system (TMACS) software configuration management plan; TOPICAL

    International Nuclear Information System (INIS)

    GLASSCOCK, J.A.

    1999-01-01

    This Software Configuration Management Plan (SCMP) describes the methodology for control of computer software developed and supported by the Systems Development and Integration (SD and I) organization of Lockheed Martin Services, Inc. (LMSI) for the Tank Monitor and Control System (TMACS). This plan controls changes to the software and configuration files used by TMACS. The controlled software includes the Gensym software package, Gensym knowledge base files developed for TMACS, C-language programs used by TMACS, the operating system on the production machine, language compilers, and all Windows NT commands and functions which affect the operating environment. The configuration files controlled include the files downloaded to the Acromag and Westronic field instruments

  9. Environmental Control Plan for the Industrial Hygiene Field Services Facility; TOPICAL

    International Nuclear Information System (INIS)

    J. W. Donnelly

    2001-01-01

    This environmental control plan is for the Hanford Site's industrial hygiene field services facility, located in the 100-N Area. The facility is used for the maintenance and storage of respirators, respiratory equipment and testing, calibration and testing of industrial hygiene equipment, and asbestos fiber counting

  10. [Local health promotion plans: intersetoralities created in the territory].

    Science.gov (United States)

    Moysés, Simone Tetu; Franco de Sá, Ronice

    2014-11-01

    The article highlights the importance of considering the specificities of spaces/territories/ locations of individual and collective life in creating health promotion actions. It explores how this approach has conceptually consolidated respect for territoriality and territorial actions as a principle and an operational health promotion strategy. Based on the literature, the article also points to the need to envision the territory occupied as a locus to put intersetorialities into practice, giving a voice to people who live there, seek to and solve their complex problems, to existing and emerging social networks. It also presents a nationally and internationally validated strategy/method (Bamboo Method) for the development of local health promotion plans, which enables the prioritization of actions by listening to the people and to the managers.

  11. Children′s behavioral pain reactions during local anesthetic injection using cotton-roll vibration method compared with routine topical anesthesia: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Ali Bagherian

    2016-01-01

    Conclusion: It may be concluded that the cotton-roll vibration method can be more helpful than the routine topical anesthesia in reducing behavioral pain reactions in children during local anesthesia administration.

  12. Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis.

    Science.gov (United States)

    Badea, I; Taylor, M; Rosenberg, A; Foldvari, M

    2009-03-01

    SSc is a chronic progressive disorder of unknown aetiology characterized by excess synthesis and deposition of collagen and other extracellular matrix components in a variety of tissues and organs. Localized scleroderma (LS) differs from SSc in that with LS only skin and occasionally subcutaneous tissues are involved. Although rarely life threatening, LS can be disfiguring and disabling and, consequently, can adversely affect quality of life. There is no known effective treatment for LS, and various options, including, as examples, corticosteroids and other immunomodulatory agents, ultraviolet radiation and vitamin D analogues, are of unproven efficacy. Clinical trials evaluating combination therapy such as corticosteroids with MTX or UVA1 exposure with psoralens have not been established as consistently effective. New immunomodulators such as tacrolimus and thalidomide are also being evaluated. A better understanding of the molecular and cellular mechanisms of LS has led to evaluation of new treatments that modulate profibrotic cytokines such as TGF-beta and IL-4, regulate assembly and deposition of extracellular matrix components, and restore Th1/Th2 immune balance by administering IL-12 or IFN-gamma. IFN-gamma acts by directly inhibiting collagen synthesis and by restoring immune balance. In this review, we evaluate current and future treatment options for LS and cutaneous involvement in SSc. Recent advances in therapy focus mainly on anti-fibrotic agents. Delivery of these drugs into the skin as the target tissue might be a key factor in developing more effective and safer therapy.

  13. Using Epistemic Network Analysis to understand core topics as planned learning objectives

    DEFF Research Database (Denmark)

    Allsopp, Benjamin Brink; Dreyøe, Jonas; Misfeldt, Morten

    Epistemic Network Analysis is a tool developed by the epistemic games group at the University of Wisconsin Madison for tracking the relations between concepts in students discourse (Shaffer 2017). In our current work we are applying this tool to learning objectives in teachers digital preparation....... The danish mathematics curriculum is organised in six competencies and three topics. In the recently implemented learning platforms teacher choose which of the mathematical competencies that serves as objective for a specific lesson or teaching sequence. Hence learning objectives for lessons and teaching...... sequences are defining a network of competencies, where two competencies are closely related of they often are part of the same learning objective or teaching sequence. We are currently using Epistemic Network Analysis to study these networks. In the poster we will include examples of different networks...

  14. Policy integration and public involvement in the local policy process: lessons from local green planning in the Netherland

    NARCIS (Netherlands)

    Coenen, Franciscus H.J.M.

    1998-01-01

    Agenda 21 explicitly recommends the use of existing planning experience when drawing up sustainable development strategies. Many local authorities all over the world have gained experience with so-called green planning, and green plans were already addressing the escalating environmental problems

  15. Review on the Significance of Local Plan for Coastal Reclamation Development: The Case of Malacca, Malaysia

    Directory of Open Access Journals (Sweden)

    Ishak Nor Syafa’ah

    2016-01-01

    Full Text Available A Development Plan acts as a planning and controlling instrument that helps to guide in decision making of current and future development. Therefore, in the Malaysian Town and Country Planning Act 1976 (Act 172, the provision of development plan from each level of the planning administration is stated in the Act under Section 6B till Section 16B. In examining the significance of one of the many development plans in Malaysia, i.e. the local plan, this paper therefore, focuses on the provision of a local plan by the Local Planning Authority (LPA of the said area. This paper, thus, aims to evaluate the Central Malacca Local Plan since Malacca is currently experiencing rapid growth in development along the coastal area. The primary data was obtained from interviews with the related planning authorities via face-to-face method. While, secondary data was gathered from related legal documents, policies and guidelines, as well as the existing development plan for the purpose of an in-depth data. Findings revealed incapability of the existing local plan to assist the development control in deciding the planning permission for reclaimed area. The existing local plan shows no zoning for coastal reclamation area because of the rapid growing development and time consuming procedure to amend the local plan according to the Act 172. In addition, the Act 172 and the process in amending the local plan should be more flexible and able to address the current issue efficiently. Finally, the paper concludes with a suggestion for further exploration in order to achieve an operative development process and functioning practice of the local plan.

  16. Localization of the prostatic apex for radiotherapy treatment planning

    International Nuclear Information System (INIS)

    Wilder, Richard B.; Fone, Patricia D.; Jones, C. Darryl; White, Ralph DeVere

    1996-01-01

    Purpose/Objective: There is no consensus on the optimal method for localizing the prostatic apex in patients with early stage adenocarcinoma of the prostate. Some radiation oncologists have recommended that transrectal ultrasound or MRI scans be used to define the inferior border of radiation portals. The purpose of this prospective study is to assess the ability of retrograde urethrograms and CT scans to accurately define the prostatic apex in the craniocaudad dimension, using urethroscopy as a reference. Materials and Methods: Following construction of an Alpha cradle, plain radiographs of the pelvis were obtained in 15 patients with early stage adenocarcinoma of the prostate, with the tip of a urethroscope placed at the superior border of the external sphincter (which most closely approximates the prostatic apex). The scope was then withdrawn, and a retrograde urethrogram was performed. Immediately afterwards, a treatment planning CT scan of the pelvis was obtained. Since differential filling of the bladder and rectum affects the position of the prostatic apex, patients voided prior to rather than in between the 3 consecutive studies. Results: The urethroscopy-defined prostatic apex was located 28 ± 3 mm (mean ± SE) superior to the ischial tuberosities, 12 ± 1 mm (mean ± SE) superior to the urethrogram tip and 8 ± 2 mm (mean ± SE) superior to the CT-defined apex. Placement of the inferior border of the radiation portals at the ischial tuberosities would have resulted in irradiation of > 20 mm membranous and spongy urethra in all of the patients. Conclusion: Retrograde urethrograms provide more helpful information than CT scans with regard to localization of the prostatic apex and are more cost effective than sonograms or MRI scans. The prostatic apex is typically 12 mm superior to the urethrogram tip with little variability. Retrograde urethrograms allow one to spare as much urethra as possible in the radiation portals, which should theoretically reduce

  17. 25 CFR 47.8 - Who develops the local educational financial plans?

    Science.gov (United States)

    2010-04-01

    ... Section 47.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.8 Who develops the local educational financial plans? The local Bureau-operated school supervisor develops the local educational financial plan in active...

  18. Wind power planning in France (Aveyron), from State regulation to local planning

    Energy Technology Data Exchange (ETDEWEB)

    Nadai, Alain [CIRED - Centre Int. de Recherche sur l' Environnement et le Developpement (France); Labussiere, Olivier [Univ. de Pau et des Pays de l' Adour, Laboratoire Societe Environnement Territoire (France)

    2007-07-01

    Since a few years, French wind power has undertaken an unprecedented development. Few turbines are in place (756 MW), but the overall granted capacity amounts to about 2.7 GW. The administrative territory of Aveyron, one of the best wind power potential in the Country, is an interesting case for understanding the ways in which industrial wind power is being developed and regulated in France. The paper presents Aveyron wind power development by dividing it into three periods. For each period, we also sketch national developments in wind power policy.Between 1996 and 2000, Aveyron was one of the few places selected for developing wind parks under the French 'Eole 2005' call for tender. Between 2000 and 2005, French regulation shifted to fixed tariffs for small wind parks (less than 12 MW). The lack of planning approach provided developers with a window for profits. Numerous projects of small parks were submitted for development authorisation, overflowing the local administration. During the year of 2003, a new law on urbanism provided some rules for individual project developments without answering the key issue of territorial planning. In Aveyron, a local scheme devised by the decentralized branches of the State had a limited reach due to the lack of mandatory status and concentration.In July 2005, a new Energy Law imposed the design of Wind Power Development Zones (WPDZ) as a condition for tariff benefit (starting July 2007). WPDZ appeared to local actors as a promising tool but it came late. Many projects were already granted with construction permits.

  19. The Toggle Local Planner for sampling-based motion planning

    KAUST Repository

    Denny, Jory; Amato, Nancy M.

    2012-01-01

    Sampling-based solutions to the motion planning problem, such as the probabilistic roadmap method (PRM), have become commonplace in robotics applications. These solutions are the norm as the dimensionality of the planning space grows, i.e., d > 5

  20. Towards Strengths-Based Planning Strategies for Rural Localities in Finland

    Directory of Open Access Journals (Sweden)

    Rönkkö Emilia

    2017-09-01

    Full Text Available In this article, we will introduce the topic of strengths-based planning strategies for rural localities in Finland. The strengths-based approach focuses on capacity building and competence enhancement with the local people, encouraging communities to valorise, identify and mobilise existing but often unrecognised assets. Setting focus only on the deficiencies and problems easily inflicts a ‘surrender mentality‘ in places outside of the urbanisation impact, creating a narrative that both decision-makers and community members start to believe. Hence, the role and potential of smaller rural localities is easily forgotten by planners, politicians and the public at large. Addressing the scale of rural localities in spatial planning, we will first reflect upon the main findings from our earlier research project “Finnish rural localities in the 2010`s” conducted by Lahti University of Applied Sciences, the University of Oulu and Aalto University in 2013-2015. Findings from the research project affirmed the unfortunate consequences of rapid urbanisation, rational blueprint planning and overoptimistic expectations of growth in the 1960s and 70s, which have resulted in the state of permanent incompleteness in rural localities today. However, these localities possess many under-utilised strengths, and we consider it essential for the future development of rural localities to make the most of this potential, and not only tackle the downwards spiral. This requires the ability to engage local stakeholders around a common vision for the future, and strategic approach based on endogenous strengths. We will discuss these possibilities via two theoretically informed case studies. The first one, Vieremä, is situated in the region of Northern Savo, and the other one, Vääksy, is the main centre in the municipality of Asikkala, situated in the region of Päijät-Häme in Southern Finland. Our study design can be characterised as qualitative research

  1. Does the Strategic Planning of Local Development Result from the Motives Indicated in Literature? Contemporary Motivation of Polish Small Towns’ Authorities for Strategic Planning of Local Development

    OpenAIRE

    Andrzej SZTANDO

    2017-01-01

    The international literature offers a numberof motives which should incline local authoritiestoward strategic planning of local development;it also emphasizes that they should be stronglymotivated to do that. Meanwhile, their actualmotivation for such planning can remain low anddominated by motives so far unrecognized in theliterature. The article presents research confi rmingthis assumption, conducted in 2014 amongthe authorities of Polish small towns.The results reveal that the general moti...

  2. Stakeholder Attitudes, Knowledge and Engagement in Local Road Systems Planning and Decision Making

    Science.gov (United States)

    2017-10-01

    Political and policy dynamics associated with local road systems planning, management, and financing merit special attention. This study: 1) analyzes stakeholder attitudes, knowledge, and engagement about financing for local road system management, t...

  3. Local integrated resource planning (LIRP); Planejamento integrado em ambiente de planejamento local (LIRP) - geracao, transmissao e distribuicao

    Energy Technology Data Exchange (ETDEWEB)

    Fontoura Filho, R N; Schilling, M T [ELETROBRAS, Rio de Janeiro, RJ (Brazil); Pereira, J L.R. [Juiz de Fora Univ., MG (Brazil); Aires, J C.O. [Light Servicos de Eletricidade S.A., Rio de Janeiro, RJ (Brazil)

    1994-12-31

    This work makes a description of the current process for planning of power systems. It also presents a proposal that permit the definition of systems with homogeneity of risks, ideal to the local integrated resources planning (LIRP) , mainly, in a competition environment between electric utilities. (author) 7 refs., 4 figs., 3 tabs.

  4. The administrative protection of local planning authorities against decisions on a higher level

    International Nuclear Information System (INIS)

    Steinberg, R.

    1982-01-01

    The author discusses governmental planning that influences local planning's scope of organization and limits local sovereinty which is established as a guarantee for local self-government. Those conflicts occurr in the case of country planning, various specific plans (such as road construction an tower and country planning, nature conservation and landscape planning), and planning permits (decisions to establish new plans according to civil air regulations and permits according to atomic law). Then the author describes the possibilities of legal protection in the case of an action for avoidance which he illustrates with some conflicting cases, laying special emphasis on the right of action of a community, and on the justification of the action for avoidance. (HSCH) [de

  5. Public participation in town-planning applications: Tlokwe Local ...

    African Journals Online (AJOL)

    Although public participation is deemed important in South Africa, negative perceptions of its legitimacy are widely acknowledged. Inclusive town-planning processes, as instruments to address inequality, have a significant role in enhancing democracy. This article reports on a study done from a communicative planning ...

  6. The Strategic Plan and Local Economic Development of Cordoba, Argentina

    NARCIS (Netherlands)

    R. Vanella (Ricardo); C. Lucca (Carlos); J.R. Pittari (Jorge Romero); F. Steinberg (Florian); Zwanenburg Maria Zwanenburg (M.)

    2001-01-01

    textabstractThe Strategic Plan of Cordoba (SPC) is one of the few strategic urban development plans in Latin America, which has actually been implemented in the majority of its components. The SPC was conceived as a collective and global project of the city as a whole without excessive conflicting

  7. Localization of the prostatic apex for radiation treatment planning

    International Nuclear Information System (INIS)

    Algan, Oezer; Hanks, Gerald E.; Shaer, Andrew H.

    1995-01-01

    Purpose: To determine whether retrograde urethrogram, or the combination of computed tomography (CT) scan/retrograde urethrogram is more accurate for locating the magnetic resonance imaging (MRI) designated prostatic apex, and to determine whether patients treated in our department with CT/urethrogram are receiving the prescribed minimal dose to the MRI identified prostatic apex. Methods and Materials: Seventeen patients with early stage prostate cancer were enrolled in a prospective study to determine the location of the prostatic apex. All of the patients agreed to undergo MRI in addition to retrograde urethrogram, and CT of the pelvis for three dimensional (3D) treatment planning. The prostatic apex was identified on each of the studies and measured from a reference point (the most superior portion of the pubic symphysis). The location of the prostatic apex as measured by retrograde urethrogram alone and by CT/urethrogram was compared to the location of the prostatic apex as measured by MRI. Because of MRI's ability for multiplanar capabilities, and high soft tissue contrast in the region of the prostate, it was assumed to be more accurate for identifying the location of the prostatic apex, and was used as the gold standard. Results: The location of the prostatic apex as determined by the urethrogram alone was on average 5.8 mm caudad to the location on MRI (p = 0.012), while the location of the prostatic apex as determined by CT/urethrogram was 3.1 mm caudad to the location on MRI (p = 0.150). If the prostatic apex is defined at 12 mm instead of 10 mm above the urethrogram tip, the statistically significant difference between the urethrogram and the MRI is no longer present. Based on these results, all 17 patients received the minimum prescribed dose to the prostatic apex. Conclusion: CT/urethrogram correlates better with the location of the MRI determined prostatic apex, than does the urethrogram alone. Locating the prostatic apex 12 mm above the urethrogram

  8. The Capacity to Integrate and Deal with Environmental Issues in Local Transport Policy and Planning

    DEFF Research Database (Denmark)

    Hansen, Carsten Jahn

    2002-01-01

    The article identifies and discuss the capacity to integrate and deal with environmental issues in local transport policy-making and planning processes.......The article identifies and discuss the capacity to integrate and deal with environmental issues in local transport policy-making and planning processes....

  9. Business plan Locally produced and branded ware potato, Zambezi Valley, Mozambique

    NARCIS (Netherlands)

    Haverkort, A.J.; Saavedra Gonzalez, Y.R.

    2015-01-01

    This business plan has been prepared for local entrepreneurs who would like to expand their business portfolio or to start an agricultural value chain business in the potato sector in the region of Tete. The four-year business plan intends to create a locally produced and branded ware potato value

  10. The use of GIS-based support of recreational trail planning by local governments

    DEFF Research Database (Denmark)

    Olafsson, Anton Stahl; Skov-Petersen, Hans

    2014-01-01

    In the last decade, multiple GIS-based planning support systems have been developed in order to improve the basis for spatial planning. Recent research has focused on problems regarding a lack of utilisation or barriers to the use of advanced GIS and GIS-based planning support systems in planning...... applications. This paper discusses these research findings in the context of outdoor recreational planning by local governments in Denmark. According to a national survey of municipal planners, GIS-based planning support is widely used in Denmark, but more GIS is needed and is being requested for local outdoor...... recreation planning. However, considerable differences exist between the ways municipalities assess their need for and use of GIS planning support. These differences are explored in more detail using a factor analysis of planning variables and uses of GIS. Three situations are described: 1) extensive network...

  11. Optical microscopy of targeted drug delivery and local distribution in skin of a topical minocycline: implications in translational research and guidance for therapeutic dose selection (Conference Presentation)

    Science.gov (United States)

    Hermsmeier, Maiko; Sawant, Tanvee; Lac, Diana; Yamamoto, Akira; Chen, Xin; Huang, Susan Y.; Nagavarapu, Usha; Evans, Conor L.; Chan, Kin Foong; Daniels, AnnaMarie

    2017-02-01

    Acne vulgaris is a chronic inflammatory skin condition commonly resulting in negative aesthetic and social impacts on those affected. Minocycline, currently available as an oral antibiotic for moderate to severe acne, has a known minimum inhibitory concentration (MIC) for the acne-causing bacterium Propionibacterium acnes (P. acnes) in vitro, with its anti-inflammatory properties also eliciting inhibitory effects on pro-inflammatory molecules. A novel topical gel composition containing solubilized minocycline (BPX-01) has been developed to directly deliver the drug to the skin. Because minocycline is a known fluorophore, fluorescence microscopy and concurrent quantitative measurements were performed on excised human facial skin dosed with different concentrations, in order to determine the spatial distribution of the drug and quantification of its local concentration in the epidermis and the pilosebaceous unit where P. acnes generally reside. Local minocycline delivery confirmed achievement of an adequate therapeutic dose to support clinical studies. Subsequently, a 4-week double-blind, randomized, vehicle controlled clinical study was performed to assess the safety and efficacy of 1% minocycline BPX-01 applied daily. No instances of cutaneous toxicity were reported, and a greater than 1 log reduction of P. acnes count was observed at week 4 with statistical significance from baseline and vehicle control. In addition, no detectable amounts of minocycline in the plasma were reported, suggesting the potential of this new formulation to diminish the known systemic adverse effects associated with oral minocycline. Follow-on clinical plans are underway to further establish the safety of BPX-01 and to evaluate its efficacy against inflammatory acne lesions in a 225 patient multi-center dose-finding study.

  12. Co-operative planning by utilities and local authorities. A solution to solve climate change?

    International Nuclear Information System (INIS)

    Schlenzing, C.; Steidle, T.

    2001-01-01

    Since the deregulation of German energy markets 1998 we can observe diverging planning interests and priorities of the local communities on one side and the local energy utilities on the other side. This seriously endangers the consensus in local energy planning achieved in the past which will be crucial in order to identify and implement effective greenhouse gas (GHG) mitigation strategies. This paper presents a co-operative planning approach which embeds systems analysis into a well structured communication, mediation and learning process for decision making. This process is supported by the cooperative modeling system MESAP, a software for energy and environmental planning, which integrates different energy models with an energy information system. This allows to combine traditional local energy planning with the more business oriented view of the utilities. The specific design of MESAP allows for a continuous 'sustainable' planning and monitoring similar to business tools for accounting and controlling in companies. (author)

  13. Topical anesthesia

    Directory of Open Access Journals (Sweden)

    Mritunjay Kumar

    2015-01-01

    Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

  14. Does the Strategic Planning of Local Development Result from the Motives Indicated in Literature? Contemporary Motivation of Polish Small Towns’ Authorities for Strategic Planning of Local Development

    Directory of Open Access Journals (Sweden)

    Andrzej SZTANDO

    2017-06-01

    Full Text Available The international literature offers a numberof motives which should incline local authoritiestoward strategic planning of local development;it also emphasizes that they should be stronglymotivated to do that. Meanwhile, their actualmotivation for such planning can remain low anddominated by motives so far unrecognized in theliterature. The article presents research confi rmingthis assumption, conducted in 2014 amongthe authorities of Polish small towns.The results reveal that the general motivationfor strategic planning of local developmentamong 37.7% of the authorities of Polish smalltowns is low. It also disclosed that the motivefor obtaining means from the EU funds (so farunrecognized in literature was and is motivatingstrongly at least 68.6% of these authorities forthe discussed planning and, moreover, that it is ashort-lived motive. The article indicates that thissituation may also refer to other local authorities,not just the Polish ones. It also indicates that itis an unintended effect of the dependence ofmunicipal development projects’ support by themeans from the EU funds on including them inthe local development strategy. The fi nal part ofthe article presents recommendations of actionsto rectify such an unfavorable situation and forfurther studies of planning motives followed bylocal authorities.

  15. Incorporating Implementation of ITS Technologies into Local Planning Processes

    Science.gov (United States)

    1998-09-16

    In this paper, the author discusses the barriers to implementing intelligent : transportation systems (ITS) at the local level. Chief among these is the need t : o education the public. At the same time, this educational effort must be : tailored for...

  16. Localization experience and future plan of NSLS primary components

    International Nuclear Information System (INIS)

    Kim, Haesoo

    1992-01-01

    Korea Heavy Industries and Construction Company is planning to obtain technical self-reliance of the component design, manufacturing and installation of the NSLS primary components as much as the target of 87% by 1995 as indicated in the technical self-reliance plan by the Korea Electric Power Company in 1988. In order to achieve this target, Koch has been involved in the component design, manufacturing and project management of the NSLS components from the early stage of the Young 3 and 4 project. In parallel, Koch has increased the self-reliance of the various fields taking full advantage of the technical documents, computer codes, training and consultation supplied by the technology transfer agreement. This paper presents the re-evaluation of the current status of technical self reliance as well as the make up plan to be implemented during the UCH 3 and 4 project for the area identified as the weakness

  17. Local adaptation of the National Physical Activity Plan: creation of the Active Living Plan for a Healthier San Antonio.

    Science.gov (United States)

    Esparza, Laura A; Velasquez, Katherine S; Zaharoff, Annette M

    2014-03-01

    Physical inactivity and related health consequences are serious public health threats. Effective strategies to facilitate and support active-living opportunities must be implemented at national, state, and local levels. San Antonio, Texas, health department officials launched the Active Living Council of San Antonio (ALCSA) to engage the community in developing a 3- to 5-year plan to promote active living. A steering committee set preliminary ALCSA aims and established a multisector membership structure modeled after the US National Physical Activity Plan (NPAP). ALCSA adopted governance standards, increased knowledge of physical activity and health, and engaged in an 18-month collaborative master plan writing process. ALCSA selected overarching strategies and evidence-based strategies for each societal sector and adapted strategies to the local context, including tactics, measures of success, and timelines. Community and expert engagement led to a localized plan reflecting national recommendations, the Active Living Plan for a Healthier San Antonio. Multisector collaborations among governmental agencies and community organizations, which were successfully developed in this case to produce the first-ever local adaptation of the NPAP, require clearly defined expectations. Lessons learned in ALCSA's organizational and plan development can serve as a model for future community-driven efforts to increase active living.

  18. Regional Planning, Local Visions : Participatory Futuring in West Africa

    OpenAIRE

    Peter Easton

    2000-01-01

    The note examines regional planning, and future participatory methods for economic development in West Africa, based on the work carried out by the Club du Sahel - a branch of the Organization for Economic Cooperation and Development (OECD) - responsible for coordinating northern donor agencies, in support of food security, and natural resource management in the desert-edge portions of Wes...

  19. Public participation in town-planning applications: Tlokwe Local ...

    African Journals Online (AJOL)

    Ms Karen Puren, Senior Lecturer, Subject Group Urban and Regional Planning, School for Geo and Spatial Sciences, North-West University. (Potchefstroom Campus), Private ..... of the 1960s in Europe, Australia and the. United States, and the 1970s ..... expected increase in crime in the area, segregation of the community, ...

  20. Coastal Hazards and Integration of Impacts in Local Adaptation Planning

    DEFF Research Database (Denmark)

    Sørensen, Carlo Sass; Knudsen, Per; Robenhagen Mølgaard, Mads

    -efficiently adapt to and manage impacts of climate change. By construction of a common working platform that is updated with additional data and knowledge, e.g. from future regional models or extreme events, advances in sea level research can more readily be translated into concrete and local impact measures...... of governance and between research, private and public institutions, and the local communities provides: understanding of the immediate and potential future challenges; appreciation of different stakeholder motives, business agendas, legislative constraints etc., and a common focus on how to cost...

  1. Children's behavioral pain reactions during local anesthetic injection using cotton-roll vibration method compared with routine topical anesthesia: A randomized controlled trial.

    Science.gov (United States)

    Bagherian, Ali; Sheikhfathollahi, Mahmood

    2016-01-01

    Topical anesthesia has been widely advocated as an important component of atraumatic administration of intraoral local anesthesia. The aim of this study was to use direct observation of children's behavioral pain reactions during local anesthetic injection using cotton-roll vibration method compared with routine topical anesthesia. Forty-eight children participated in this randomized controlled clinical trial. They received two separate inferior alveolar nerve block or primary maxillary molar infiltration injections on contralateral sides of the jaws by both cotton-roll vibration (a combination of topical anesthesia gel, cotton roll, and vibration for physical distraction) and control (routine topical anesthesia) methods. Behavioral pain reactions of children were measured according to the author-developed face, head, foot, hand, trunk, and cry (FHFHTC) scale, resulting in total scores between 0 and 18. The total scores on the FHFHTC scale ranged between 0-5 and 0-10 in the cotton-roll vibration and control methods, respectively. The mean ± standard deviation values of total scores on FHFHTC scale were lower in the cotton-roll vibration method (1.21 ± 1.38) than in control method (2.44 ± 2.18), and this was statistically significant (P anesthesia in reducing behavioral pain reactions in children during local anesthesia administration.

  2. Strategic environmental assessment for local transport plans; Strategische Umweltpruefung in der kommunalen Verkehrsentwicklung

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, Vera

    2008-08-15

    The strategic environmental assessment (SEA) makes new demands for plans and programs also in the transport sector. Particularly on local level transport is one of the biggest causers of negative environmental effects. But there exists no SEA obligation for local transport plans, however many factors suggest to make such an examination in this sector. At the latest in the urban land use planning transport effects are a component for the SEA. Synergies can be exhausted and the individual planning steps are appropriately co-ordinated by the meaningful integration of transport and urban development planning. Additional synergies can gained in connection with further local and/or regional planning like e.g. the clean air planning or noise reduction planning. The aim of the doctoral thesis is to draft recommendations how to integrate the SEA into local transport planning process. For that purpose it is necessary to deduce the requirements demanded by the SEA and to demonstrate the current state of the local transport planning. The doctoral thesis is based on partial results of the research project FE 73.0237 ''Strategische Umweltpruefung in der kommunalen Verkehrsentwicklungsplanung'' in behalf of the German Ministry of Transport (Bundesministerium fuer Verkehr, Bauen und Stadtentwicklung) and mentored by the Federal Office of civil engineering (Bundesamt fuer Bauwesen und Raumordnung). The author of this thesis was instrumental in acquiring those results. The thesis contains a detailed literature research. The SEA's requirements are also described as well as the current state of the local transport planning. The state of the SEA on the different planning levels in the German transport sector is presented. Another part is a survey of 13 municipalities concerning their previous practice of the local transport and environmental planning as well as their experience with the SEA on local level and the analyse of local data. Furthermore three

  3. Local climate action plans in climate change mitigation

    DEFF Research Database (Denmark)

    Damsø, Tue Noa Jacques; Kjær, Tyge; Christensen, Thomas Budde

    2016-01-01

    the extent, targets and scope of LG CAPs and find that Danish LGs are highly involved in mitigation activities with a widespread CAP adoption and an overall high degree of sectoral coverage on base year accounts and action plans, albeit with some significant shortcomings. Different approaches for target...... and scope definition are identified and assessed, and the overall contribution of LGs to the Danish energy transition is discussed....

  4. LOCAL ECONOMIC DEVELOPMENT (LED PLANNING IN THE FACE OF GLOBALISATION

    Directory of Open Access Journals (Sweden)

    Constantin BRĂGARU

    2017-05-01

    Full Text Available Local economic development and workforce initiative are continually evolving. There are no hard and fast rules or long-proven experiences upon which to draw. The job of the economic development planner and the work of the community in achieving sustainable economic development have become much harder because of the national and global crisis.

  5. Constraint-based local search for container stowage slot planning

    DEFF Research Database (Denmark)

    Pacino, Dario; Jensen, Rune Møller; Bebbington, Tom

    2012-01-01

    -sea vessels. This paper describes the constrained-based local search algorithm used in the second phase of this approach where individual containers are assigned to slots in each bay section. The algorithm can solve this problem in an average of 0.18 seconds per bay, corresponding to a 20 seconds runtime...

  6. Local agenda 21 and planning practice: structural transformation or window dressing?

    OpenAIRE

    Doak, Joe

    2001-01-01

    Local Agenda 21 seeks the meaningful involvement of a wide range of local groups and stakeholders in the formulation and implementation of public policy and a free flow of communication and discussion between them and their respective local authorities (and other areas and levels of decision-making). This paper explores the reality of this process using case study evidence from local planning practice in Liverpool (in the north of England) and Reading (in the south of the country). It concent...

  7. Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

    International Nuclear Information System (INIS)

    Cao, Wenhua; Lim, Gino J.; Li, Yupeng; Zhu, X. Ronald; Zhang, Xiaodong

    2015-01-01

    Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT) treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment

  8. Topical medication utilization and health resources consumption in adult patients affected by psoriasis: findings from the analysis of administrative databases of local health units

    Directory of Open Access Journals (Sweden)

    Perrone V

    2017-03-01

    Full Text Available Valentina Perrone, Diego Sangiorgi, Stefano Buda, Luca Degli Esposti Clicon S.r.l. Health, Economics & Outcomes Research, Ravenna, Italy Aim: The objectives of this study were to: 1 analyze the drug utilization pattern among adult psoriasis patients who were newly prescribed with topical medication; and 2 assess their adherence to topical therapy and the possibility of switching to other strategies in the treatment process. Methods: An observational retrospective analysis was conducted based on administrative databases of two Italian local health units. All adult subjects who were diagnosed with psoriasis or who were newly prescribed for topical medication with at least one prescription between January 1, 2010, and December 31, 2014, were screened. Only patients who were “non-occasional users of topical drugs” (if they had at least two prescriptions of topical drugs in a time space of 2 years were considered for the first and second objectives in the analysis. The date of the first prescription of topical agents was identified as the index date (ID, which was then followed for all time available from ID (follow-up period. The adherence to therapy was assessed on the basis of cycles of treatment covered in the 6 months before the end of the follow-up period. The mean health care costs in patients who switched to disease-modifying antirheumatic drugs (DMARDs or biologics after the ID were evaluated. Results: A total of 17,860 patients with psoriasis who were newly prescribed for topical medication were identified. A total of 2,477 were identified as “non-occasional users of topical drugs”, of whom 70.2% had a prescription for a topical fixed combination regimen at ID. Around 19% adhered to their medication, whereas 6% switched to other options of psoriasis treatment. Multivariable logistic regression model shows that patients on fixed combination treatment were less likely to be non-adherent to treatment and less likely to switch to

  9. Bicycle-friendly infrastructure planning in Beijing and Copenhagen - between adapting design solutions and learning local planning cultures

    DEFF Research Database (Denmark)

    Zhao, Chunli; Carstensen, Trine Agervig; Nielsen, Thomas Alexander Sick

    2018-01-01

    Abstract Cities around the world are constructing bicycle infrastructure to increase cycling. However, identifying efficient design solutions and determining how bicycle infrastructure planning knowledge can be integrated into comprehensive policy remains a challenge. The objective of this paper...... is to shed light on the strengths and weaknesses of current bicycle infrastructure planning in both an experienced city, Copenhagen, and in a less experienced city, Beijing. The paper examines how local design solutions are identified, how efficient they are and to what extent bicycle infrastructure planning...

  10. District officials learn how to use the Atlas in local planning

    CSIR Research Space (South Africa)

    Murambadoro, M

    2011-11-01

    Full Text Available District Municipality environmental officers attending the 2011 SRRP training workshop were introduced to the South African Risk and Vulnerability Atlas (SARVA) as a vital tool for local planning and resilience. This workshop was aimed at raising...

  11. Coastal Hazards and Integration of Impacts in Local Adaptation Planning

    Science.gov (United States)

    Knudsen, P.; Sorensen, C.; Molgaard, M. R.; Broge, N. H.; Andersen, O. B.

    2016-12-01

    Data on sea and groundwater levels, precipitation, land subsidence, geology, and geotechnical soil properties are combined with information on flood and erosion protection measures to analyze water-related impacts from climate change at an exposed coastal location. Future sea extremes will have a large impact but several coupled effects in the hydrological system need to be considered as well to provide for optimal protection and mitigation efforts. For instance, the investment and maintenance costs of securing functional water and wastewater pipes are significantly reduced by incorporating knowledge about climate change. The translation of regional sea level rise evidence and projections to concrete impact measures should take into account the potentially affected stakeholders who must collaborate on common and shared adaptation solutions. Here, knowledge integration across levels of governance and between research, private and public institutions, and the local communities provides: understanding of the immediate and potential future challenges; appreciation of different stakeholder motives, business agendas, legislative constraints etc., and a common focus on how to cost-efficiently adapt to and manage impacts of climate change. By construction of a common working platform that is updated with additional data and knowledge, e.g. from future regional models or extreme events, advances in sea level research can more readily be translated into concrete and local impact measures in a way that handles uncertainties in the future climate and urban development as well as suiting the varying stakeholder needs.

  12. LEAP: local environmental action plan. Municipality of Kriva Palanka

    International Nuclear Information System (INIS)

    2004-01-01

    The Municipality of Kriva Palanka. in terms of geography. occupies the northeastern part of Republic of Macedonia, spreading over at an altitude of 450 m to 2 252 m (the peak of Ruen) above the sea level of the Osogovo area. The main sources of air pollution in the Municipality have been identified to be: population, intensive traffic and industry, as well as other polluters causing negative impacts on human health and environment, such as local communal landfill (burning of waste at illegal dumping sites), frequent forest fires, exhaust gases from local heating facilities of households; air released from mining ventilation and dust from tailings; indoor smoking, as well as noise from various ambiental and internal sources. Industrial facilities also affect the quality of the ambient air in the region, the most significant being Lead and Zinc Mine 'Toranica', textile factory 'Karpos', lumber processing enterprise 'Treska', etc. The main industrial air polluter in the region is Lead and Zinc Mine 'Toranica' with its tailings disposal site and flotation tailings located 17 km from Kriva Palanka. The severe environmental problem, has been assessed as risk posing by 74.7% of the respondents involved in the survey. 85.1% of the respondents involved in the survey have recognized pollution from tailing landfills of Lead and Zinc Mine 'Toranica' and Krastov Dol' as risk posing

  13. Local government GIS and geospatial capabilities : suitability for integrated transportation and land use planning (California SB 375).

    Science.gov (United States)

    2009-11-01

    This report examines two linked phenomena in transportation planning: the geospatial analysis capabilities of local planning agencies and the increasing demands on such capabilities imposed by comprehensive planning mandates. The particular examples ...

  14. Simulation to Support Local Search in Trajectory Optimization Planning

    Science.gov (United States)

    Morris, Robert A.; Venable, K. Brent; Lindsey, James

    2012-01-01

    NASA and the international community are investing in the development of a commercial transportation infrastructure that includes the increased use of rotorcraft, specifically helicopters and civil tilt rotors. However, there is significant concern over the impact of noise on the communities surrounding the transportation facilities. One way to address the rotorcraft noise problem is by exploiting powerful search techniques coming from artificial intelligence coupled with simulation and field tests to design low-noise flight profiles which can be tested in simulation or through field tests. This paper investigates the use of simulation based on predictive physical models to facilitate the search for low-noise trajectories using a class of automated search algorithms called local search. A novel feature of this approach is the ability to incorporate constraints directly into the problem formulation that addresses passenger safety and comfort.

  15. A neo-strategic planning approach to enhance local tobacco control programs.

    Science.gov (United States)

    Douglas, Malinda R; Carter, Sara Sally R; Wilson, Andrew P; Chan, Andie

    2015-01-01

    Research in tobacco control demonstrating best practices is widely disseminated; however, application at the local level is often difficult. Translating research into practice requires a concerted effort to develop an understanding of the evidence and how it can be applied within diverse contexts. A strategic planning infrastructure was developed to support the translation of evidence-based interventions into community practice. This paper highlights the strategic process of turning "know-what" into "know-how" to facilitate the strategic planning and implementation of tobacco control best practices at the local level. The purpose, people, process, and product strategies of knowledge management and translation provided a framework for the strategic planning infrastructure. The knowledge translation concepts of audience, motivations, and mechanisms were synergized in the neo-strategic planning component design. The participants were 20 community coalitions funded to implement local tobacco control programs. From 2004 to 2011, the strategic planners facilitated a cyclical process to translate research into practice using a trio of integrated tools, skill-building workshops on strategic planning, and grantee-driven technical assistance and consultation. In the short term, the usefulness of the strategic planning components to the programs was measured. The intermediate outcome was the successful movement of the community programs from the planning stage to the implementation stage. The achievement of community-level changes in planned tobacco control efforts was the overall outcome measure for the success of the local coalitions. Seventeen of 20 communities that began the planning process implemented strategic plans. All 17 of the programs implemented evidence-based practices, resulting in numerous tobacco-free policies, increased cessation, and increased support from the media and community. Bridging the gap between research and practice can enhance the practicality

  16. LEAP: local environmental action plan. Municipality of Sopishte

    International Nuclear Information System (INIS)

    2004-01-01

    The establishment of the Municipality of Sopishte was preceded by the development of a kind of suburban settlement of Skopje, basically composed of illegally constructed individual houses for living. As a result from economic activities in the Municipality and the impacts from human factor, there are problems related to the disturbance of the quality of the basic environmental quality factors (water, air and soil), as well as threat to biological diversity and natural values and rarities. The Municipality of Sopishte is situated in hilly-mountain area. Significant sources of air pollution have not been recorded (in terms of industrial facilities) caused by the household neglectible air pollution caused by traffic. The Municipality is very poor in water resources. Almost 90% of the Municipality's territory are without river or stream. A potential source of water supply in this area is the river of Patishka, which is currently not used for water supply purposes. The solid waste, generated basically by the households, is not properly disposed (most frequently dumped on illegal dumping sites on the territory of the Municipality) and represents a serious problem making impacts on the quality of the environment. On the basis of the evaluation of identified environmental problems, priority activities required to be undertaken in short and medium term have been set up. Financial constrains have been taken into account in this regard. The proposed Action Plan reflects the observed needs of the population of the Municipality of Sopishte and the perception of the key problems

  17. No antiinflammatory effect of short-term topical and subcutaneous administration of local anesthetics on postburn inflammation

    DEFF Research Database (Denmark)

    Møiniche, S; Dahl, J B; Brennum, J

    1993-01-01

    , development of blister and ulcerations, or the intensity of inflammation after burn injury between the control legs and EMLA- or bupivacaine-treated legs, respectively. CONCLUSION. No antiinflammatory effect of short-term preinjury and postinjury topical 5% EMLA or subcutaneous 0.5% bupivacaine could...... and left calves with a 15 x 25 mm rectangular thermode. Eight subjects had topical 5% EMLA applied before and after burn injury, and another eight subjects were administered subcutaneous 0.5% bupivacaine infiltration before burn injury on the right or left leg. No treatment was applied to the contralateral...... leg in either group because this served as the control. The dermal response after burn injury in test areas with EMLA or bupivacaine and without treatment was compared 24 hours, 72 hours, 168 hours, and 14 days after burn injury. RESULTS. No significant difference was found in the area of flare...

  18. LEAP: local environmental action plan. Municipality of Dolneni

    International Nuclear Information System (INIS)

    2004-01-01

    The Municipality of Dolneni is situated in the northern part of the Pelagonia Valley, at about 600 meters above the sea level. It is surrounded on three sides (north, northeast, east and northwest) by the mountain massifs of Dautica, Babuna and Busova Planina. The assesment of the state of the environment in the Municipality of Dolneni presented in this document is based on several principles, including, before all, human health, as well as impacts from human activities on urban and natural environment, social and economic development, etc. The impacts from environmental pollution on human health in the Municipality of Dolneni are evident. Major problem is the lack of sewerage system to collect wastewater and absence of organized landfill(s) for solid waste disposal. In addition, the improper drinking water supply in most of the settlements contributes to the increased human health risk in the Municipality. The absence of urban planning has lead to developments and uncontrolled use of natural resources that cause degradation of the environment and consequently decrease in quality of living for the population. The above problems affect the quality of living conditions and human health both directly and indirectly. In recent years, incidence of epidemics of communicable hepatitis was recovered (Debreste, Desovo), and there is a concern for a high risk of appearance of intestinal and other infectious diseases. There are no indicators of the soil quality of surface running water resources with regard to pollution. In any case, on the basis of the manner of land use and specific human activities on the territory of the Municipality, as well as on the basis of the above mentioned solid waste and waste water related problems, it may be concluded that these resources are in a rather poor condition. Other aspects of determining the quality of the environment (atmosphere, noise, natural ecosystems and biodiversity in general) are not under serious human pressure at present

  19. The rhetoric and realities of integrating air quality into the local transport planning process in English local authorities.

    Science.gov (United States)

    Olowoporoku, Dotun; Hayes, Enda; Longhurst, James; Parkhurst, Graham

    2012-06-30

    Regardless of its intent and purposes, the first decade of the Local Air Quality Management (LAQM) framework had little or no effect in reducing traffic-related air pollution in the UK. Apart from the impact of increased traffic volumes, the major factor attributed to this failure is that of policy disconnect between the process of diagnosing air pollution and its management, thereby limiting the capability of local authorities to control traffic-related sources of air pollution. Integrating air quality management into the Local Transport Plan (LTP) process therefore presents opportunities for enabling political will, funding and joined-up policy approach to reduce this limitation. However, despite the increased access to resources for air quality measures within the LTP process, there are local institutional, political and funding constraints which reduce the impact of these policy interventions on air quality management. This paper illustrate the policy implementation gaps between central government policy intentions and the local government process by providing evidence of the deprioritisation of air quality management compared to the other shared priorities in the LTP process. We draw conclusions on the policy and practice of integrating air quality management into transport planning. The evidence thereby indicate the need for a policy shift from a solely localised hotspot management approach, in which the LAQM framework operates, to a more holistic management of vehicular emissions within wider spatial administrative areas. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Local governance of energy. Clarification of stakes and illustration by spatial planning

    International Nuclear Information System (INIS)

    Saujot, Mathieu; Ruedinger, Andreas; Guerry, Anais

    2014-01-01

    As energy transition implies important societal transformations, the authors developed an analysis framework about the main questions raised by local governance: role of the different levels of local communities in the definition and implementation of strategies, key stakes of the sharing of skills between the State and communities, and stakes regarding spatial planning in this context. The authors first address the issue of relevance of the different territorial scales in a context of evolution of energy policies. They propose an overview of this issue with reference to the debate on local governance of transition. They discuss the return on experience of decentralisation in other fields of action of local policies, notably urban planning and spatial planning

  1. Progress in improving provincial plans for nutrition through targeted technical assistance and local advocacy in Vietnam.

    Science.gov (United States)

    Harris, Jody; Nguyen, Phuong H; To, Quyen; Frongillo, Edward A; Menon, Purnima

    2016-12-01

    Vietnam has been decentralizing nutrition planning to provinces, which could help with local relevance and accountability. Assessment in 2009 found a continuing top-down approach, limited human capacity, and difficulty in integrating multiple sectors. Alive and Thrive (A&T) provided targeted assistance and capacity-building for 15 provincial plans for nutrition (PPNs). We aimed to (i) assess PPN content and quality improvements 2009-2014, and (ii) explain processes through which change occurred. Data consisted of interview-based assessments of provincial planning processes, annual PPN assessments, and tracking of A&T involvement. At endline, some provinces produced higher quality plans. Local planning skills improved, but capacity remained insufficient. Awareness of and support for nutrition improved, but some policy and legal environments were contradictory. Objectives were clearer, but use of data for planning remained inconsistent. Provinces became more proactive and creative, but remained constrained by slow approval processes and insufficient funding. Targeted assistance and local advocacy can improve decentralized planning, with success dependent on policy and programming contexts and ability to overcome constraints around capacity, investment, data use and remnants of centralized planning. We recommend strong engagement with planners at the national level to understand how to unblock major constraints; solutions must take into consideration the particular political, financial and administrative context. © The Author 2016. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.

  2. Stakeholders' Perception on National Heatwave Plans and Their Local Implementation in Belgium and The Netherlands.

    Science.gov (United States)

    van Loenhout, Joris Adriaan Frank; Rodriguez-Llanes, Jose Manuel; Guha-Sapir, Debarati

    2016-11-10

    National heatwave plans are aimed at reducing the avoidable human health consequences due to heatwaves, by providing warnings as well as improving communication between relevant stakeholders. The objective of this study was to assess the perceptions of key stakeholders within plans in Belgium and The Netherlands on their responsibilities, the partnerships, and the effectiveness of the local implementation in Brussels and Amsterdam. Key informant interviews were held with stakeholders that had an important role in development of the heatwave plan in these countries, or its implementation in Brussels or Amsterdam. Care organisations, including hospitals and elderly care organisations, had a lack of familiarity with the national heatwave plan in both cities, and prioritised heat the lowest. Some groups of individuals, specifically socially isolated individuals, are not sufficiently addressed by the current national heatwave plans and most local plans. Stakeholders reported that responsibilities were not clearly described and that the national plan does not describe tasks on a local level. We recommend to urgently increase awareness on the impact of heat on health among care organisations. More emphasis needs to be given to the variety of heat-risk groups. Stakeholders should be involved in the development of updates of the plans.

  3. The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

    Directory of Open Access Journals (Sweden)

    Wohlrab J

    2013-11-01

    Full Text Available Johannes Wohlrab,1 Franziska Voß,2 Christian Müller,2 Lars C Brenn21Department of Dermatology and Venereology, Martin Luther University of Halle-Wittenberg, Halle, 2Department of Medical Science and Operations, Riemser Pharma GmbH, Greifswald, GermanyBackground: Frequent outbreak of herpes labialis can affect quality of life by prodromes like burning, itching, and swelling. Topical applied preparations aim to shorten the duration of symptoms, inhibit the virus replication and/or accelerate the healing process. Local concentrated heat (LCH can reduce burning, itching, or swelling of the skin by influence of mechano-heat sensitive afferent neurons.Patients and methods: To examine the effectiveness of two different topical applications (LCH versus topical acyclovir [TACV] under real life conditions, we conducted a prospective, observational, reference-controlled cohort pilot study with 103 patients. Occurrence of prodromal burning, itching, swelling, and quality of life were assessed.Results: The LCH observation group (OG showed a significantly faster improvement in all symptoms after 1-day of application than the TACV OG. The burden and duration of disease was lower and shorter in the LCH OG than in the TACV OG.Conclusions: The prodromal symptoms in recurrent herpes labialis were attenuated more effectively by LCH than by TACV.Keywords: herpes labialis, local concentrated heat, acyclovir

  4. Maximizing dosimetric benefits of IMRT in the treatment of localized prostate cancer through multicriteria optimization planning

    International Nuclear Information System (INIS)

    Wala, Jeremiah; Craft, David; Paly, Jon; Zietman, Anthony; Efstathiou, Jason

    2013-01-01

    We examine the quality of plans created using multicriteria optimization (MCO) treatment planning in intensity-modulated radiation therapy (IMRT) in treatment of localized prostate cancer. Nine random cases of patients receiving IMRT to the prostate were selected. Each case was associated with a clinically approved plan created using Corvus. The cases were replanned using MCO-based planning in RayStation. Dose-volume histogram data from both planning systems were presented to 2 radiation oncologists in a blinded evaluation, and were compared at a number of dose-volume points. Both physicians rated all 9 MCO plans as superior to the clinically approved plans (p −5 ). Target coverage was equivalent (p = 0.81). Maximum doses to the prostate and bladder and the V50 and V70 to the anterior rectum were reduced in all MCO plans (p<0.05). Treatment planning time with MCO took approximately 60 minutes per case. MCO-based planning for prostate IMRT is efficient and produces high-quality plans with good target homogeneity and sparing of the anterior rectum, bladder, and femoral heads, without sacrificing target coverage

  5. Maximizing dosimetric benefits of IMRT in the treatment of localized prostate cancer through multicriteria optimization planning

    Energy Technology Data Exchange (ETDEWEB)

    Wala, Jeremiah; Craft, David [Harvard Medical School, Boston, MA (United States); Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Paly, Jon [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Zietman, Anthony [Harvard Medical School, Boston, MA (United States); Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Efstathiou, Jason, E-mail: jefstathiou@partners.org [Harvard Medical School, Boston, MA (United States); Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States)

    2013-10-01

    We examine the quality of plans created using multicriteria optimization (MCO) treatment planning in intensity-modulated radiation therapy (IMRT) in treatment of localized prostate cancer. Nine random cases of patients receiving IMRT to the prostate were selected. Each case was associated with a clinically approved plan created using Corvus. The cases were replanned using MCO-based planning in RayStation. Dose-volume histogram data from both planning systems were presented to 2 radiation oncologists in a blinded evaluation, and were compared at a number of dose-volume points. Both physicians rated all 9 MCO plans as superior to the clinically approved plans (p<10{sup −5}). Target coverage was equivalent (p = 0.81). Maximum doses to the prostate and bladder and the V50 and V70 to the anterior rectum were reduced in all MCO plans (p<0.05). Treatment planning time with MCO took approximately 60 minutes per case. MCO-based planning for prostate IMRT is efficient and produces high-quality plans with good target homogeneity and sparing of the anterior rectum, bladder, and femoral heads, without sacrificing target coverage.

  6. A controlled clinical study on the new topical dosage form of DHEP plasters in patients suffering from localized inflammatory diseases.

    Science.gov (United States)

    Rosenthal, M; Bahous, I

    1993-01-01

    In this clinical study the efficacy and the tolerability of a new topical formulation, DHEP plaster, have been evaluated. The plaster consists of an auto-adhesive medicated gauze pad of standard dimensions (10 x 15 cm) containing 180 mg DHEP. The reference drug was a well-known topical drug, diclofenac diethylammonium (DDA) emulgel at 1.16%. Treatments were applied to the affected area for 14 days: DHEP plaster b.i.d. and DDA emulgel q.i.d. A total of 190 patients, affected by various inflammatory diseases, participated in this clinical study. In both treatment groups (DHEP n = 96 patients, DDA n = 94 patients) a clear improvement in the disease and a rapid reduction in pain were observed. The statistical comparison between the two treatments showed a significant difference in favour of DHEP. However a comparison of the results, according to the different diagnoses, did not reveal any statistical significance. Both treatments were well tolerated, although five (DHEP n = 2, DDA n = 3) out of the 190 patients (2.6%) showed transient side effects (pruritus or erythema, both of light intensity).

  7. Comparative analysis of elements and models of implementation in local-level spatial plans in Serbia

    Directory of Open Access Journals (Sweden)

    Stefanović Nebojša

    2017-01-01

    Full Text Available Implementation of local-level spatial plans is of paramount importance to the development of the local community. This paper aims to demonstrate the importance of and offer further directions for research into the implementation of spatial plans by presenting the results of a study on models of implementation. The paper describes the basic theoretical postulates of a model for implementing spatial plans. A comparative analysis of the application of elements and models of implementation of plans in practice was conducted based on the spatial plans for the local municipalities of Arilje, Lazarevac and Sremska Mitrovica. The analysis includes four models of implementation: the strategy and policy of spatial development; spatial protection; the implementation of planning solutions of a technical nature; and the implementation of rules of use, arrangement and construction of spaces. The main results of the analysis are presented and used to give recommendations for improving the elements and models of implementation. Final deliberations show that models of implementation are generally used in practice and combined in spatial plans. Based on the analysis of how models of implementation are applied in practice, a general conclusion concerning the complex character of the local level of planning is presented and elaborated. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR 36035: Spatial, Environmental, Energy and Social Aspects of Developing Settlements and Climate Change - Mutual Impacts and Grant no. III 47014: The Role and Implementation of the National Spatial Plan and Regional Development Documents in Renewal of Strategic Research, Thinking and Governance in Serbia

  8. Integrating the environment in local strategic planning : Guidelines (Case of Morocco)

    Science.gov (United States)

    Benbrahim, Hafsa

    2018-05-01

    Since 2010, an advanced regionalization project has been initiated by Morocco, which plans to consolidate the processes of decentralization and deconcentration by extending the powers of the regions and other local authorities. This project, institutionalized in the 2011 Constitution, defines the territorial organization of the Kingdom and reinforces decentralization according to a model of advanced regionalization. Through advanced regionalization, Morocco aims at integrated and sustainable development in economic, social, cultural and environmental terms, through the development of the potential and resources of each region. However, in order to honor this commitment of advanced regionalization, local authorities must be assisted in adopting a local strategic planning approach, allowing them to develop territorial plans for sustainable development in accordance with the national legal framework, specifically the Framework law 99-12, and international commitments in terms of environmental protection. This research deals with the issue of environmental governance in relation to the role and duties of local authorities. Thus, the main goal of our study is to present the guidelines to be followed by the local authorities to improve the quality of the environment integration process in the local strategic planning with the aim of putting it in a perspective of sustainable development.

  9. City of North Vancouver greenhouse gas local action plan : final report

    International Nuclear Information System (INIS)

    Hood, I.

    2005-02-01

    This paper presented details of a greenhouse gas (GHG) local action plan developed as a result of the City of North Vancouver's participation in the Partners for Climate Protection Program (PCPP). The plan is intended to better manage the impacts of urban development related to GHG and air quality, while also achieving community objectives related to affordable housing, transportation management, job creation and economic development. The report reviewed the local emissions inventory in addition to various programs, plans, policies and by-laws relating to energy management. Potential policies and programs were identified to achieve GHG emissions reductions in accordance with the PCPP. A plan for emissions reductions was also presented. A situation analysis was presented with details of population, transportation, residential and commercial building and industry. Solid waste management and transportation plans were outlined. A GHG emissions profile and forecast was presented. An outline of a GHG management framework included information on initiatives in the city as well as details of public consultation feedback. A program implementation plan includes forecasts of the program's impact, as well as details of program delivery and a performance measurement framework. Proposed initiatives in the plan included new building guidelines; fuel switching for light and heavy duty vehicles; driver training and enhanced vehicle maintenance programs; and, an environmental procurement policy. Community programs include residential and commercial building retrofits; land use planning; support for community energy systems; green building design guidelines; transportation demand management; and, public engagement and outreach programs. 21 tabs., 9 figs

  10. Local Path Planning of Driverless Car Navigation Based on Jump Point Search Method Under Urban Environment

    Directory of Open Access Journals (Sweden)

    Kaijun Zhou

    2017-09-01

    Full Text Available The Jump Point Search (JPS algorithm is adopted for local path planning of the driverless car under urban environment, and it is a fast search method applied in path planning. Firstly, a vector Geographic Information System (GIS map, including Global Positioning System (GPS position, direction, and lane information, is built for global path planning. Secondly, the GIS map database is utilized in global path planning for the driverless car. Then, the JPS algorithm is adopted to avoid the front obstacle, and to find an optimal local path for the driverless car in the urban environment. Finally, 125 different simulation experiments in the urban environment demonstrate that JPS can search out the optimal and safety path successfully, and meanwhile, it has a lower time complexity compared with the Vector Field Histogram (VFH, the Rapidly Exploring Random Tree (RRT, A*, and the Probabilistic Roadmaps (PRM algorithms. Furthermore, JPS is validated usefully in the structured urban environment.

  11. Making Strategic Planning Work in Local Government: An Empirical Study of Success And Failure

    Directory of Open Access Journals (Sweden)

    Ángel IGLESIAS

    2015-10-01

    Full Text Available Since the 1990s, local governments all over Europe have launched reforms to improve local democracy, public management and efficiency in the provision of local services. Some of these reforms are inspired by what previously has worked in private management and some of them have also a macro-level approach, whose main aim is to introduce institutional reforms and reorganizations to ensure contextual problem solving by strengthening governance within the local public sector. In this context, Strategic Planning in public organizations has attracted interest among academic researchers and practitioners as an instrument for dealing with a complex environment and for the achievement of higher performance and the attainment of greater democracy. But the decision on how to introduce Strategic Planning might follow a different rationale. The hypothesis maintained in this paper is that those that are based in an endogenous rationale are more likely to succeed. To test our hypothesis this paper draws on a comparative empirical analysis concerning the design and implementation of a Strategic Planning process within two Spanish city governments: one considered to have been a failure and the other a success. Focusing on the way in which the use of Strategic Planning has to face the trade-offs between urban and economic development and democracy, the paper explores how this formal mechanism of citizen´s and business’ participation serves to establish relational processes to reinvigorate local economic development, democracy and administrative modernization only when a strong political and administrative leadership is put into motion. Overall, the study yields evidence consistent with the notion that a successful Strategic Planning at the local level has to take into account not only institutional issues, but also the communal, social and political resources that frame the deliberations propelled by the Strategic Planning process.

  12. State and local planning procedures dealing with social and economic impacts from nuclear power plants

    International Nuclear Information System (INIS)

    Curry, M.; Goodrieght, J.; Green, M.; Merwin, D.; Smith, R.

    1977-01-01

    The roles of state and local agencies in planning for and managing social and economic impacts of nuclear power plants are studied. In order to be effective in these roles state and local agencies must work with each other as well as the NRC. A comparative case study approach is used which analyzes six sites in three West Coast states. The case studies included plants in operation, plants under construction, and plants still in the planning stages. In contrast to some states, all three of these states have moderately centralized procedures for siting power plants, and all have strong environmental laws

  13. The Influence Of Planning Decisions Regarding Land Evaluation Based On A Selected Local Real Estate Market

    Directory of Open Access Journals (Sweden)

    Foryś Iwona

    2015-12-01

    Full Text Available The article analyzes the influence of planning decisions on changes taking place on the local real estate market. Three stages of the planning process are studied in particular, i.e.: the passing of the study of conditions and directions of spatial development, the Commune Council Resolution on initiating the formulation of a local spatial development plan, and finally the Resolution on accepting the local plan, as well as the effects of these activities on the land value in a given real estate market in Stargard Szczeciński, in the West-Pomeranian (Zachodniopomorskie Province of Poland. The object of the research is to identify the indicated relationships on a given real estate market, on which respective spatial planning stages can be distinguished, as well as the strength and course of the analyzed relationships. The study will verify the research hypothesis regarding the strength and directions of the effects of planning decisions as the direct and indirect reasons behind price changes on the real estate market. The analysis uses data from the Price Register and the District Starosty Values, along with statistical and public information data and the authors' own studies.

  14. TRANSPARENCY OF LOCAL AND REGIONAL SELF-GOVERNMENT IN THE PUBLICATION OF PROCUREMENT PLAN WEB SITE

    Directory of Open Access Journals (Sweden)

    Tomislav Šušnjar

    2016-12-01

    Full Text Available The main objective of this paper was to determine whether there is a Procurement Plan for 2016, on the website of local and regional selfgovernment units in the Republic of Croatia. After having applied the method of analysis, the hypothesis that local and regional self-governments in the Republic of Croatia fulfilled their legal obligation to publish the procurement plan to websites, was not confirmed. The research results show that all counties except for Međimurje County have a Procurement Plan for 2016 available on their respective websites. Out of the total of 127 cities in the Republic of Croatia, ten cities (Belišće, Čabar, Donji Miholjac, Drniš, Ilok, Imotski, Nova Gradiška, Pleternica, Popovača and Vrgorac did not publish their Procurement Plans for 2016. In addition, the survey results show that 61 municipalities do not have a published Procurement Plan for 2016 on their respective websites. This study may contribute to the knowledge of the local and regional self- government units’ websites contents in the Republic of Croatia, and encourage the employees to comply with the legal obligation to publish the procurement plan on their websites for the purpose of conducting transparent procurement.

  15. local

    Directory of Open Access Journals (Sweden)

    Abílio Amiguinho

    2005-01-01

    Full Text Available The process of socio-educational territorialisation in rural contexts is the topic of this text. The theme corresponds to a challenge to address it having as main axis of discussion either the problem of social exclusion or that of local development. The reasons to locate the discussion in this last field of analysis are discussed in the first part of the text. Theoretical and political reasons are there articulated because the question is about projects whose intentions and practices call for the political both in the theoretical debate and in the choices that anticipate intervention. From research conducted for several years, I use contributions that aim at discuss and enlighten how school can be a potential locus of local development. Its identification and recognition as local institution (either because of those that work and live in it or because of those that act in the surrounding context are crucial steps to progressively constitute school as a partner for development. The promotion of the local values and roots, the reconstruction of socio-personal and local identities, the production of sociabilities and the equation and solution of shared problems were the dimensions of a socio-educative intervention, markedly globalising. This scenario, as it is argued, was also, intentionally, one of transformation and of deliberate change of school and of the administration of the educative territoires.

  16. Local health and social care responses to implementing the national cold weather plan.

    Science.gov (United States)

    Heffernan, C; Jones, L; Ritchie, B; Erens, B; Chalabi, Zaid; Mays, N

    2017-09-18

    The Cold Weather Plan (CWP) for England was launched by the Department of Health in 2011 to prevent avoidable harm to health by cold weather by enabling individuals to prepare and respond appropriately. This study sought the views of local decision makers involved in the implementation of the CWP in the winter of 2012/13 to establish the effects of the CWP on local planning. It was part of a multi-component independent evaluation of the CWP. Ten LA areas were purposively sampled which varied in level of deprivation and urbanism. Fifty-two semi-structured interviews were held with health and social care managers involved in local planning between November 2012 and May 2013. Thematic analysis revealed that the CWP was considered a useful framework to formalize working arrangements between agencies though local leadership varied across localities. There were difficulties in engaging general practitioners, differences in defining vulnerable individuals and a lack of performance monitoring mechanisms. The CWP was welcomed by local health and social care managers, and improved proactive winter preparedness. Areas for improvement include better integration with general practice, and targeting resources at socially isolated individuals in cold homes with specific interventions aimed at reducing social isolation and building community resilience. © The Author 2017. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  17. Guidelines for Preservation, Conservation, and Restoration of Local History and Local Genealogical Materials.

    Science.gov (United States)

    RQ, 1993

    1993-01-01

    Presents guidelines adopted by the American Library Association (ALA) relating to the preservation, conservation, and restoration of local history and local genealogical materials. Topics addressed include assessing preservation needs; developing a plan; choosing appropriate techniques, including microduplication, photoduplication, electronic…

  18. Planning experience and prospects of local participation in implementation of nuclear power in Bangladesh

    International Nuclear Information System (INIS)

    Rahman, M.A.; Islam, A.B.M.N.; Quaiyum, M.A.; Hasnat, K.A.; Hossain, M.

    1983-01-01

    The paper summarizes the overall experience of Bangladesh in planning for the introduction of its nuclear power programme. The basis for selection of the type of contract for the first nuclear power project of the country is explained. The paper then analyses the prospect of local participation in the construction of the first nuclear power station by detailing the local capabilities in fields such as civil works, civil works materials supply, electrical/mechanical supplies, mechanical fabrication/erection, transportation, etc. After analysing the domestic infrastructure, the problem areas are identified and measures necessary to improve the degree of local participation are described. (author)

  19. Local Government Systems and Decentralization: Evidence from Pakistan’s Devolution Plan

    Directory of Open Access Journals (Sweden)

    Muhammad Shakil Ahmad

    2013-03-01

    Full Text Available The discourse of governance and development practitioners continues to embrace community participation and community empowerment as an elementary means of building local capacity for poverty reduction, development and change at the local level. This article is a review of the decentralization initiatives of local government systems after the announcement of the devolution plan in Pakistan. It evaluates the initiatives’ participatory methods to ascertain the extent to which they have improved the process of community development at the local level. This article also measures the impact of community empowerment on the sustainability of community-driven projects implemented under the decentralization initiative through community-based organizations known as Citizen Community Boards (CCBs. Document analysis and literature review methodologies were employed to gain further insight into the decentralization phenomenon in Pakistan. The results describe human development, improvements in community empowerment and the sustainability of local projects; however, the sense of community has yet to be translated into shared benefits for rural communities. The fundamental goal of decentralization seems to be elusive because only power was transferred to the local level, whereas there is little support for community capacity building and community access to resources and the elites still control the electoral process. It is argued that community development initiatives in Pakistan require continuous support from local governments to boost local rural economies. Likewise, community-local government participatory development strategies can lead to strong local ownership and empowerment in rural communities.

  20. Localizing Climate Information for Municipal Planning in the Central U.S.

    Science.gov (United States)

    Shulski, M.; Umphlett, N.; Abdel-Monem, T.; Tang, Z.; Uhlarik, F.

    2017-12-01

    The impacts of projected climate change are an ongoing concern for municipalities. Planning at the local level often involves investigations of multiple hazards on decadal timescales. Of particular interest to cities are implications of too much or too little water, snow storms, heat waves, and freeze/thaw cycles on infrastructure, health, energy demands and water quality and availability. A two-year project led by the University of Nebraska - Lincoln has brought together scientist and stakeholder for the purpose of informing municipal planning and climate adaptation for 12 cities in the lower Missouri River Basin states (IA, NE, KS, MO). City-specific climate reports have been developed with municipal input to aid local planning efforts. Surveys to assess municipal climate data usage were distributed to all cities with a population greater than 5,000 in the four-state region. In addition, planning efforts for 18 municipalities have been evaluated for nearly 20 cities in the region to investigate local hazard mitigation, emergency, and comprehensive plans. This presentation will outline key outcomes of the project and discuss decision support tools developed in co-production with city planners.

  1. 25 CFR 47.10 - How is the local educational financial plan developed?

    Science.gov (United States)

    2010-04-01

    ....10 Section 47.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.10 How is the local educational financial... plan: (1) Within 15 days after receiving the tentative allotment, the school supervisor must consult...

  2. Clinical implementation of coverage probability planning for nodal boosting in locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Ramlov, Anne; Assenholt, Marianne S; Jensen, Maria F

    2017-01-01

    PURPOSE: To implement coverage probability (CovP) for dose planning of simultaneous integrated boost (SIB) of pathologic lymph nodes in locally advanced cervical cancer (LACC). MATERIAL AND METHODS: CovP constraints for SIB of the pathological nodal target (PTV-N) with a central dose peak...

  3. Can Perceptions of Environmental and Climate Change in Island Communities Assist in Adaptation Planning Locally?

    Science.gov (United States)

    Aswani, Shankar; Vaccaro, Ismael; Abernethy, Kirsten; Albert, Simon; de Pablo, Javier Fernández-López

    2015-12-01

    Local perceptions of environmental and climate change, as well as associated adaptations made by local populations, are fundamental for designing comprehensive and inclusive mitigation and adaptation plans both locally and nationally. In this paper, we analyze people's perceptions of environmental and climate-related transformations in communities across the Western Solomon Islands through ethnographic and geospatial methods. Specifically, we documented people's observed changes over the past decades across various environmental domains, and for each change, we asked respondents to identify the causes, timing, and people's adaptive responses. We also incorporated this information into a geographical information system database to produce broad-scale base maps of local perceptions of environmental change. Results suggest that people detected changes that tended to be acute (e.g., water clarity, logging intensity, and agricultural diseases). We inferred from these results that most local observations of and adaptations to change were related to parts of environment/ecosystem that are most directly or indirectly related to harvesting strategies. On the other hand, people were less aware of slower insidious/chronic changes identified by scientific studies. For the Solomon Islands and similar contexts in the insular tropics, a broader anticipatory adaptation planning strategy to climate change should include a mix of local scientific studies and local observations of ongoing ecological changes.

  4. Local niche planning and its strategic implications for implementation of energy-efficient technology

    DEFF Research Database (Denmark)

    Quitzau, Maj-Britt; Hoffmann, Birgitte; Elle, Morten

    2012-01-01

    -management process for enabling transitions. The study outlines the proactive spatial planning of a Danish local authority in order to illustrate how the strategic work performed in this kind of local development project represents a special form of niche management that is able to create room for innovation...... such a gap between policy visions and their implementation in practice specific forms of strategic work is needed, according to new transformative ideas in spatial planning. The aim of this paper is to characterize the transformative capacities of this kind of strategic work at the spatial scale of the town...... in order to assess how such activities engage with sustainable transitions. The theoretical contribution of the paper is to compare strategic work performed in transformative forms of spatial planning with the strategic work intended in strategic niche management, which represent a change...

  5. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.

    Science.gov (United States)

    Li, Suzanne C; Torok, Kathryn S; Pope, Elena; Dedeoglu, Fatma; Hong, Sandy; Jacobe, Heidi T; Rabinovich, C Egla; Laxer, Ronald M; Higgins, Gloria C; Ferguson, Polly J; Lasky, Andrew; Baszis, Kevin; Becker, Mara; Campillo, Sarah; Cartwright, Victoria; Cidon, Michael; Inman, Christi J; Jerath, Rita; O'Neil, Kathleen M; Vora, Sheetal; Zeft, Andrew; Wallace, Carol A; Ilowite, Norman T; Fuhlbrigge, Robert C

    2012-08-01

    Juvenile localized scleroderma (LS) is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies has been reported in the literature, a lack of agreement on treatment specifics and accepted methods for clinical assessment has made it difficult to compare approaches and identify optimal therapy. Our objective was to develop standardized treatment plans, clinical assessments, and response criteria for active, moderate to high severity juvenile LS. A core group of pediatric rheumatologists, dermatologists, and a lay advisor was engaged by the Childhood Arthritis and Rheumatology Research Alliance (CARRA) to develop standardized treatment plans and assessment parameters for juvenile LS using consensus methods/nominal group techniques. Recommendations were validated in 2 face-to-face conferences with a larger group of practitioners with expertise in juvenile LS and with the full membership of CARRA, which encompasses the majority of pediatric rheumatologists in the US and Canada. Consensus was achieved on standardized treatment plans that reflect the prevailing treatment practices of CARRA members. Standardized clinical assessment methods and provisional treatment response criteria were also developed. Greater than 90% of pediatric rheumatologists responding to a survey (66% of CARRA membership) affirmed the final recommendations and agreed to utilize these consensus plans to treat patients with juvenile LS. Using consensus methodology, we have developed standardized treatment plans and assessment methods for juvenile LS. The high level of support among pediatric rheumatologists will support future comparative effectiveness studies and enable the development of evidence-based guidelines for the treatment of juvenile LS. Copyright © 2012 by the American College of Rheumatology.

  6. From local development policies to strategic planning-Assessing continuity in institutional coalitions.

    Science.gov (United States)

    Mazzeo Rinaldi, Francesco

    2016-06-01

    In the last two decades, EU policies have had a fundamental role in orienting regional/local development. The objective of this work is set in this context as it intends to analyze the local development programs activated in Sicily in the last three programming periods. The main aim is to explore whether the EU partnership principle influenced cooperation among local actors, assessing the continuity of local institutional coalition in managing different local development programs within the regional development policy system. We focus, in particular, on Strategic Plans (SP) promoted in Sicily in the transition phase between the 2000-2006 and the 2007-2013 periods. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Tourism Development and Planning at a Local Authority Level: A Case in Manjung, Perak, Malaysia

    Directory of Open Access Journals (Sweden)

    Md Saad Nor Hasliza

    2014-01-01

    Full Text Available Due to the importance of the tourism industry in the country, it is crucial to ensure that local authorities in Malaysia implement sustainable tourism development. In the 10th Malaysian Plan, the government set a key target to be achieved for the tourism sector. One of the key parties responsible for ensuring that the set targets are achieved is the local authorities, who are responsible for providing proper maintenance because the tourism destinations fall under their area of jurisdiction. The aim of this article is to explore tourism development and planning in one of the popular tourism destination and to analyse the role that local authorities play in the development process. This paper explores the local authorities’ views and opinions on their tourism development area using interview and focus group approaches. The paper also combines the analysis of government policy and planning documents with a review of tourism development literature. The findings reveal challenges and issues that are experienced by the local authorities in regard to setting the direction, development and management of tourism development. The issues of tourism development are then discussed for the government to ensure tourism development sustainability in the long term.

  8. Strategic energy planning within local authorities in the UK: A study of the city of Leeds

    International Nuclear Information System (INIS)

    Bale, Catherine S.E.; Foxon, Timothy J.; Hannon, Matthew J.; Gale, William F.

    2012-01-01

    This paper considers the development of a strategic energy body in a local authority in the UK and looks at the perceived need for, and possible roles of, such a body. Historically, energy provision and management has not usually been a strategic priority for UK local authorities. Yet energy considerations are implicit in key local authority responsibilities such as transport, waste management, planning, and the provision of housing services. In addition, recent UK central government policies support the move to localism and provide incentives for low-carbon energy generation. A study was undertaken to assess the potential (including both the perceived benefits and actual capacity to deliver) for Leeds City Council to develop a strategic body to execute delivery of city-level energy decision-making. We examine the perceived benefits to a range of main stakeholders, using data drawn from interviews with managers responsible for low-carbon and renewable energy projects across the city. Through participant observation we explore the capacity of a local authority to deliver a strategic energy body, and we briefly examine the possible forms of delivery. We conclude with recommendations for national policy that would enable the development of strategic energy bodies across local governments in the UK. - Highlights: ► Strategic energy planning is currently not a priority for UK local authorities. ► We present an empirical study of strategic energy planning in local authorities. ► Results from stakeholder interviews suggest support for a strategic energy body. ► We identify the capacity barriers to implementing a strategic energy body. ► We make recommendations for ways forward and support needed from national policy.

  9. Auditing local methods for quality assurance in radiotherapy using the same set of predefined treatment plans

    Directory of Open Access Journals (Sweden)

    Enrica Seravalli

    2018-01-01

    Full Text Available Background and purpose: Local implementation of plan-specific quality assurance (QA methods for intensity-modulated radiotherapy (IMRT and volumetric modulated arc therapy (VMAT treatment plans may vary because of dissimilarities in procedures, equipment and software. The purpose of this work is detecting possible differences between local QA findings and those of an audit, using the same set of treatment plans. Methods: A pre-defined set of clinical plans was devised and imported in the participating institute’s treatment planning system for dose computation. The dose distribution was measured using an ionisation chamber, radiochromic film and an ionisation chamber array. The centres performed their own QA, which was compared to the audit findings. The agreement/disagreement between the audit and the institute QA results were assessed along with the differences between the dose distributions measured by the audit team and computed by the institute. Results: For the majority of the cases the results of the audit were in agreement with the institute QA findings: ionisation chamber: 92%, array: 88%, film: 76% of the total measurements. In only a few of these cases the evaluated measurements failed for both: ionisation chamber: 2%, array: 4%, film: 0% of the total measurements. Conclusion: Using predefined treatment plans, we found that in approximately 80% of the evaluated measurements the results of local QA of IMRT and VMAT plans were in line with the findings of the audit. However, the percentage of agreement/disagreement depended on the characteristics of the measurement equipment used and on the analysis metric. Keywords: Quality assurance, Dosimetry audit, IMRT, VMAT, QA devices

  10. SEA in local land use planning - first experience in the Alpine States

    International Nuclear Information System (INIS)

    Jiricka, Alexandra; Proebstl, Ulrike

    2008-01-01

    In the Alpine area, planning decisions can result in far-reaching consequences because of the high sensitivity of the Alpine ecosystems. This article is based on two hypotheses: (1) The Alpine states/regions were aware of their sensitive environment and therefore recognized the necessity of introducing a comparable instrument to assess local land use planning. (2) By introducing this differentiated assessment tool, namely SEA, an increase in costs may be the consequence. However, better and more transparent planning can contribute to the enhancement of planning standards. To reveal the validity of these assumptions the legal implementation in the Alpine countries Austria, Germany, Italy and France was examined as well as first practical experience resulting from the determined procedures. The results of the implementation process in the four states were compared and discussed on the basis of selected process steps of SEA

  11. Advantages and limitations of navigation-based multicriteria optimization (MCO) for localized prostate cancer IMRT planning

    International Nuclear Information System (INIS)

    McGarry, Conor K.; Bokrantz, Rasmus; O’Sullivan, Joe M.; Hounsell, Alan R.

    2014-01-01

    Efficacy of inverse planning is becoming increasingly important for advanced radiotherapy techniques. This study’s aims were to validate multicriteria optimization (MCO) in RayStation (v2.4, RaySearch Laboratories, Sweden) against standard intensity-modulated radiation therapy (IMRT) optimization in Oncentra (v4.1, Nucletron BV, the Netherlands) and characterize dose differences due to conversion of navigated MCO plans into deliverable multileaf collimator apertures. Step-and-shoot IMRT plans were created for 10 patients with localized prostate cancer using both standard optimization and MCO. Acceptable standard IMRT plans with minimal average rectal dose were chosen for comparison with deliverable MCO plans. The trade-off was, for the MCO plans, managed through a user interface that permits continuous navigation between fluence-based plans. Navigated MCO plans were made deliverable at incremental steps along a trajectory between maximal target homogeneity and maximal rectal sparing. Dosimetric differences between navigated and deliverable MCO plans were also quantified. MCO plans, chosen as acceptable under navigated and deliverable conditions resulted in similar rectal sparing compared with standard optimization (33.7 ± 1.8 Gy vs 35.5 ± 4.2 Gy, p = 0.117). The dose differences between navigated and deliverable MCO plans increased as higher priority was placed on rectal avoidance. If the best possible deliverable MCO was chosen, a significant reduction in rectal dose was observed in comparison with standard optimization (30.6 ± 1.4 Gy vs 35.5 ± 4.2 Gy, p = 0.047). Improvements were, however, to some extent, at the expense of less conformal dose distributions, which resulted in significantly higher doses to the bladder for 2 of the 3 tolerance levels. In conclusion, similar IMRT plans can be created for patients with prostate cancer using MCO compared with standard optimization. Limitations exist within MCO regarding conversion of navigated plans to

  12. Organizational Conflict In Local Management Budget Planning In Raja Ampat Regency

    Directory of Open Access Journals (Sweden)

    Baba

    2015-01-01

    Full Text Available ABSTRACT Local government leadership in Raja Ampat based on the writers observation yet effectively perform conflict resolution organizations in the area of financial management. This is evident from the acquisition of predicate disclaimer that occur repeatedly. Disclaimer predicate occurs repeatedly in the area of financial management in Raja Ampat because the local government leadership has not been effective in reducing conflicts that have a negative effect on the performance of individuals and the performance of positions in all SKPDs not implementing more effective management strategies in order to moderate the conflict related to disagreements about the task policy and other organizational issues and less effective in stimulating the learning process SKPDs level with regard to financial management area. Based on the above description organizational conflict studies in the area of financial management in Raja Ampat is important and urgent to do. The importance of this study because of financial management in Raja Ampat still face the task of conflict situations and conflict relations in the budget planning. The purpose of this study is to 1 Describe the forms of organizational conflicts in planning budget in Raja Ampat.2 Describe the sources of conflict in the organization of planning budget in Raja Ampat. 3 Analyze the conflict resolution organizations in planning budget in Raja Ampat. Based on several conclusions can be drawn as follows 1In the budget planning are forms of task conflict and relationship conflict. 2 Sources of conflict in the budget planning is the difference in the organizations goals criteria that do not work worth it and the inequality of treatment between sub-units. 3 Conflict resolution is a budget planning by providing an understanding of the meaning-Term Development Plan and the area and ask for advice and input from the Regent to accommodate the pricing to be more flexible to adjust to market conditions and the

  13. Effectiveness of various formulations of local anesthetics and additives for topical anesthesia – a prospective, randomized, double-blind, placebo-controlled study

    Directory of Open Access Journals (Sweden)

    Weilbach C

    2017-05-01

    , the addition of trometamol (Tris/THAM accelerated the onset of the effect compared to the native formulation (at 0.4 and 0.8 N. In all of the adult subjects of this study, the minimum exposure time was 60 min for any of the tested topical anesthetic creams.Conclusion: The results of this study indicate that a cream containing 20% lidocaine, 38% trometamol and 10% propylene glycol may be used as an alternative to lidocaine/prilocaine with a comparable effect and without the need to extend exposure time. Keywords: local anesthetics, topical anesthesia, EMLA®, topical anesthetic cream, lidocaine, prilocaine 

  14. Evolution of Botswana planning education in light of local and international requirements

    Directory of Open Access Journals (Sweden)

    Cavrić Branko

    2011-01-01

    Full Text Available Planning problems have been with us ever since human beings realized that their wellbeing is very closely linked to the quality of their settlements and the environment. Over the last century this has led to the worldwide emergence of built environment education in general, and planning in particular. In many African universities planning education is a rapidly growing phenomenon reaching its maturity in terms of structure and number of programs. This development has been most significant in those countries that underwent rapid urbanization and environmental changes similar to those occurring in Botswana. The first Urban and Regional Planning Programme at the University of Botswana was established in 1993 as part of the Department of Environmental Science at the Faculty of Science. The continued growth and expansion of the planning profession world-wide as well as in Botswana, and its interdisciplinary ties with allied built-environment disciplines, have reached the point at which the University of Botswana is ready to continue with a new internationally recognized planning school. There is a belief that a combined (spatial and specialist accredited planning programme should support local and regional interests, focusing on the Southern African Region, while acknowledging global standards and innovation in teaching, research, and technology.

  15. Enhancing local action planning through quantitative flood risk analysis: a case study in Spain

    Science.gov (United States)

    Castillo-Rodríguez, Jesica Tamara; Escuder-Bueno, Ignacio; Perales-Momparler, Sara; Ramón Porta-Sancho, Juan

    2016-07-01

    This article presents a method to incorporate and promote quantitative risk analysis to support local action planning against flooding. The proposed approach aims to provide a framework for local flood risk analysis, combining hazard mapping with vulnerability data to quantify risk in terms of expected annual affected population, potential injuries, number of fatalities, and economic damages. Flood risk is estimated combining GIS data of loads, system response, and consequences and using event tree modelling for risk calculation. The study area is the city of Oliva, located on the eastern coast of Spain. Results from risk modelling have been used to inform local action planning and to assess the benefits of structural and non-structural risk reduction measures. Results show the potential impact on risk reduction of flood defences and improved warning communication schemes through local action planning: societal flood risk (in terms of annual expected affected population) would be reduced up to 51 % by combining both structural and non-structural measures. In addition, the effect of seasonal population variability is analysed (annual expected affected population ranges from 82 to 107 %, compared with the current situation, depending on occupancy rates in hotels and campsites). Results highlight the need for robust and standardized methods for urban flood risk analysis replicability at regional and national scale.

  16. Station, local, and public participation plan, Salt Repository Project Office, Deaf Smith County, Texas: Draft

    International Nuclear Information System (INIS)

    1987-12-01

    The purpose of the SRPO State, Local, and Public Participation Plan is to provide an ''umbrella'' document for the ongoing and planned institutional involvement. One of the major goals is to develop project-specific outreach and participation programs based on input received from interested parties. DOE's commitment to interaction and information programs is to be demonstrated by conducting activities in an open environment, listening to and understanding the concerns of interested parties, actively involving affected parties in the program, executing faithfully the intent of Congress expressed through the NWPA, and providing equitable treatment for all affected parties. 1 fig., 2 tabs

  17. Corrective Action Plan for Corrective Action Unit 261: Area 25 Test Cell A Leachfield System, Nevada Test Site, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    T. M. Fitzmaurice

    2000-01-01

    This Corrective Action Plan (CAP) has been prepared for the Corrective Action Unit (CAU)261 Area 25 Test Cell A Leachfield System in accordance with the Federal Facility and Consent Order (Nevada Division of Environmental Protection[NDEP] et al., 1996). This CAP provides the methodology for implementing the approved corrective action alternative as listed in the Corrective Action Decision Document (U.S. Department of Energy, Nevada Operations Office, 1999). Investigation of CAU 261 was conducted from February through May of 1999. There were no Constituents of Concern (COCs) identified at Corrective Action Site (CAS) 25-05-07 Acid Waste Leach Pit (AWLP). COCs identified at CAS 25-05-01 included diesel-range organics and radionuclides. The following closure actions will be implemented under this plan: Because COCs were not found at CAS 25-05-07 AWLP, no action is required; Removal of septage from the septic tank (CAS 25-05-01), the distribution box and the septic tank will be filled with grout; Removal of impacted soils identified near the initial outfall area; and Upon completion of this closure activity and approval of the Closure Report by NDEP, administrative controls, use restrictions, and site postings will be used to prevent intrusive activities at the site

  18. Planning and Implementing Immunization Billing Programs at State and Local Health Departments: Barriers and Possible Solutions.

    Science.gov (United States)

    Corriero, Rosemary; Redmon, Ginger

    Before participating in a project funded by the Centers for Disease Control and Prevention, most state and local health departments (LHDs) were not seeking reimbursement or being fully reimbursed by insurance plans for the cost of immunization services (including vaccine costs and administration fees) they provided to insured patients. Centers for Disease Control and Prevention's Billables Project was designed to enable state and LHDs to bill public and private insurance plans for immunization services provided to insured patients. Identify and describe key barriers state and LHDs may encounter while planning and implementing a billing program, as well as possible solutions for overcoming those barriers. This study used reports from Billables Project participants to explore barriers they encountered when planning and implementing a billing program and steps taken to address those barriers. Thirty-eight state immunization programs. Based on project participants' reports, barriers were noted in 7 categories: (1) funding and costs, (2) staff, (3) health department characteristics, (4) third-party payers and insurance plans, (5) software, (6) patient insurance status, and (7) other barriers. Possible solutions for overcoming those barriers included hiring or seeking external help, creating billing guides and training modules, streamlining workflows, and modifying existing software systems. Overcoming barriers during planning and implementation of a billing program can be challenging for state and LHDs, but the experiences and suggestions of past Billables Project participants can help guide future billing program efforts.

  19. 40 CFR 109.5 - Development and implementation criteria for State, local and regional oil removal contingency plans.

    Science.gov (United States)

    2010-07-01

    ... regional oil removal contingency plans. Criteria for the development and implementation of State, local and... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Development and implementation criteria for State, local and regional oil removal contingency plans. 109.5 Section 109.5 Protection of...

  20. 20 CFR 661.290 - Under what circumstances may States require Local Boards to take part in regional planning...

    Science.gov (United States)

    2010-04-01

    ... what circumstances may States require Local Boards to take part in regional planning activities? (a... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Under what circumstances may States require Local Boards to take part in regional planning activities? 661.290 Section 661.290 Employees' Benefits...

  1. Spatial planning via extremal optimization enhanced by cell-based local search

    International Nuclear Information System (INIS)

    Sidiropoulos, Epaminondas

    2014-01-01

    A new treatment is presented for land use planning problems by means of extremal optimization in conjunction to cell-based neighborhood local search. Extremal optimization, inspired by self-organized critical models of evolution has been applied mainly to the solution of classical combinatorial optimization problems. Cell-based local search has been employed by the author elsewhere in problems of spatial resource allocation in combination with genetic algorithms and simulated annealing. In this paper it complements extremal optimization in order to enhance its capacity for a spatial optimization problem. The hybrid method thus formed is compared to methods of the literature on a specific characteristic problem. It yields better results both in terms of objective function values and in terms of compactness. The latter is an important quantity for spatial planning. The present treatment yields significant compactness values as emergent results

  2. High Performance Electrical Modeling and Simulation Software Normal Environment Verification and Validation Plan, Version 1.0; TOPICAL

    International Nuclear Information System (INIS)

    WIX, STEVEN D.; BOGDAN, CAROLYN W.; MARCHIONDO JR., JULIO P.; DEVENEY, MICHAEL F.; NUNEZ, ALBERT V.

    2002-01-01

    The requirements in modeling and simulation are driven by two fundamental changes in the nuclear weapons landscape: (1) The Comprehensive Test Ban Treaty and (2) The Stockpile Life Extension Program which extends weapon lifetimes well beyond their originally anticipated field lifetimes. The move from confidence based on nuclear testing to confidence based on predictive simulation forces a profound change in the performance asked of codes. The scope of this document is to improve the confidence in the computational results by demonstration and documentation of the predictive capability of electrical circuit codes and the underlying conceptual, mathematical and numerical models as applied to a specific stockpile driver. This document describes the High Performance Electrical Modeling and Simulation software normal environment Verification and Validation Plan

  3. Engineering task plan for upgrades to the leveling jacks on core sample trucks number 3 and 4; TOPICAL

    International Nuclear Information System (INIS)

    KOSTELNIK, A.J.

    1999-01-01

    Characterizing the waste in underground storage tanks at the Hanford Site is accomplished by obtaining a representative core sample for analysis. Core sampling is one of the numerous techniques that have been developed for use given the environmental and field conditions at the Hanford Site. Core sampling is currently accomplished using either Push Mode Core Sample Truck No.1 or; Rotary Mode Core Sample Trucks No.2, 3 or 4. Past analysis (WHC 1994) has indicated that the Core Sample Truck (CST) leveling jacks are structurally inadequate when lateral loads are applied. WHC 1994 identifies many areas where failure could occur. All these failures are based on exceeding the allowable stresses listed in the American Institute of Steel Construction (AISC) code. The mode of failure is for the outrigger attachments to the truck frame to fail resulting in dropping of the CST and possible overturning (Ref. Ziada and Hundal, 1996). Out of level deployment of the truck can exceed the code allowable stresses in the structure. Calculations have been performed to establish limits for maintaining the truck level when lifting. The calculations and the associated limits are included in appendix A. The need for future operations of the CSTS is limited. Sampling is expected to be complete in FY-2001. Since there is limited time at risk for continued use of the CSTS with the leveling controls without correcting the structural problems, there are several design changes that could give incremental improvements to the operational safety of the CSTS with limited impact on available operating time. The improvements focus on making the truck easier to control during lifting and leveling. Not all of the tasks identified in this ETP need to be performed. Each task alone can improve the safety. This engineering task plan is the management plan document for implementing the necessary additional structural analysis. Any additional changes to meet requirements of standing orders shall require a

  4. Radiological emergency response planning: Handbook for Federal Assistance to State and Local Governments

    International Nuclear Information System (INIS)

    1978-12-01

    The handbook is directed toward those federal agencies involved in providing direct field assistance to state and local governments in radiological emergency response planning. Its principal purpose is to optimize the effectiveness of this effort by specifying the functions of the following federal agencies: Nuclear Regulatory Commission, Environmental Protection Agency, Department of Energy, Department of Health, Education, and Welfare, Department of Transportation, Defense Civil Preparedness Agency, Federal Disaster Assistance Administration, and Federal Preparedness Agency

  5. Health Aspects of Climate Change in Cities with Mediterranean Climate, and Local Adaptation Plans.

    Science.gov (United States)

    Paz, Shlomit; Negev, Maya; Clermont, Alexandra; Green, Manfred S

    2016-04-21

    Cities with a Mediterranean-type climate (Med-cities) are particularly susceptible to health risks from climate change since they are located in biogeographical hot-spots that experience some of the strongest effects of the changing climate. The study aims to highlight health impacts of climate change in Med-cities, analyze local climate adaptation plans and make adaptation policy recommendations for the Med-city level. We identified five Med-cities with a climate change adaptation plan: Adelaide, Barcelona, Cape Town, Los Angeles and Santiago. Beyond their similar Med-climate features (although Santiago's are slightly different), the cities have different socio-economic characteristics in various aspects. We analyzed each plan according to how it addresses climate change-related drivers of health impacts among city dwellers. For each driver, we identified the types of policy adaptation tools that address it in the urban climate adaptation plans. The surveyed cities address most of the fundamental climate change-related drivers of risks to human health, including rising temperatures, flooding and drought, but the policy measures to reduce negative impacts vary across cities. We suggest recommendations for Med-cities in various aspects, depending on their local needs and vulnerability challenges: assessment of health risks, extreme events management and long-term adaptation, among others.

  6. 20 CFR 661.345 - What are the requirements for the submission of the local workforce investment plan?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are the requirements for the submission of the local workforce investment plan? 661.345 Section 661.345 Employees' Benefits EMPLOYMENT AND... disagreement with the plan to the Governor along with the plan. ...

  7. Determining Coastal Hazards Risk Perception to Enhance Local Mitigation Planning through a Participatory Mapping Approach

    Science.gov (United States)

    Bethel, M.; Braud, D.; Lambeth, T.; Biber, P.; Wu, W.

    2017-12-01

    Coastal community leaders, government officials, and natural resource managers must be able to accurately assess and predict a given coastal landscape's sustainability and/or vulnerability as coastal habitat continues to undergo rapid and dramatic changes associated with natural and anthropogenic activities such as accelerated relative sea level rise (SLR). To help address this information need, a multi-disciplinary project team conducted Sea Grant sponsored research in Louisiana and Mississippi with traditional ecosystem users and natural resource managers to determine a method for producing localized vulnerability and sustainability maps for projected SLR and storm surge impacts, and determine how and whether the results of such an approach can provide more useful information to enhance hazard mitigation planning. The goals of the project are to develop and refine SLR visualization tools for local implementation in areas experiencing subsidence and erosion, and discover the different ways stakeholder groups evaluate risk and plan mitigation strategies associated with projected SLR and storm surge. Results from physical information derived from data and modeling of subsidence, erosion, engineered restoration and coastal protection features, historical land loss, and future land projections under SLR are integrated with complimentary traditional ecological knowledge (TEK) offered by the collaborating local ecosystem users for these assessments. The data analysis involves interviewing stakeholders, coding the interviews for themes, and then converting the themes into vulnerability and sustainability factors. Each factor is weighted according to emphasis by the TEK experts and number of experts who mention it to determine which factors are the highest priority. The priority factors are then mapped with emphasis on the perception of contributing to local community vulnerability or sustainability to SLR and storm surge. The maps are used by the collaborators to benefit

  8. A comparison of different three-dimensional treatment planning techniques for localized radiotherapy of prostate cancer

    International Nuclear Information System (INIS)

    Koswig, S.; Dinges, S.; Buchali, A.; Boehmer, D.; Salk, J.; Rosenthal, P.; Harder, C.; Schlenger, L.; Budach, V.

    1999-01-01

    Purpose: Four different three-dimensional planning techniques for localized radiotherapy of prostate cancer were compared with regard to dose homogeneity within the target volume and dose to organs at risk, dependent upon tumor stage. Patients and Methods: Six patients with stage T1, 7 patients with stage T2 and 4 patients with stage T3 were included in this study. Four different 3D treatment plans (rotation, 4-field, 5-field and 6-field technique) were calculated for each patient. Dose was calculated with the reference point at the isocenter (100%). The planning target volume was encompassed within the 95% isodose surface. All the techniques used different shaped portal for each beam. Dose volume histograms were created and compared for the planning target volume and the organs at risk (33%, 50%, 66% volume level) in all techniques. Results: The 4 different three-dimensional planning techniques revealed no differences concerning dose homogeneity within the planning target volume. The dose volume distribution at organs at risk show differences between the calculated techniques. In our study the best protection for bladder and rectum in stage T1 and T2 was achieved by the 6-field technique. A significant difference was achieved between 6-field and 4-field technique only in the 50% volume of the bladder (p=0.034), between the 6-field and rotation technique (all volume levels) and between 5-field and rotation technique (all volume levels). In stage T1, T2 6-field and 4-field technique in 50% (p-0.033) and 66% (p=0.011) of the rectum volume. In stage T3 a significant difference was not observed between the 4 techniques. The best protection of head of the femur was achieved by the rotation technique. Conclusion: In the localized radiotherapy of prostate cancer in stage T1 or T2 the best protection for bladder and rectum was achieved by a 3D-planned conformal 6-field technique. If the seminal vesicles have been included in the target volume and in the case of large

  9. Difficult balances and impossible partners. The implementation local plan for San Giovanni a Teduccio in Naples.

    Directory of Open Access Journals (Sweden)

    Enrico Formato

    2014-02-01

    Full Text Available This article is about the processes involved in preparing the preliminary draft of the implementation local plan (ILP of the San Giovanni a Teduccio district of Naples (2008. The plan, drawn up during the activities of the Innovative programme in the urban field (PIAU financed by the Ministry of Infrastructure in 2004, aims to integrate a series of initiatives, already in progress or planned in the district for the designing of public space, by giving special attention to the redevelopment of the waterfront and the strengthening of its relationships with the city. In the given conditions, the solutions proposed by the plan represent the most advanced point of balance between different visions which general urban planning and subsequent programme agreements can bring about. Finally, ILP’s work is subjected to a persistent contradiction, a structural incompatibility between the activities of the commercial port and the renovation of the waterfront: port and city generate a dialectic which, at present, is not conducive either to economic development based on the logistics or to urban renovation. Why don’t we look for other options rather than this unfruitful incompatibility?

  10. Process planning optimization on turning machine tool using a hybrid genetic algorithm with local search approach

    Directory of Open Access Journals (Sweden)

    Yuliang Su

    2015-04-01

    Full Text Available A turning machine tool is a kind of new type of machine tool that is equipped with more than one spindle and turret. The distinctive simultaneous and parallel processing abilities of turning machine tool increase the complexity of process planning. The operations would not only be sequenced and satisfy precedence constraints, but also should be scheduled with multiple objectives such as minimizing machining cost, maximizing utilization of turning machine tool, and so on. To solve this problem, a hybrid genetic algorithm was proposed to generate optimal process plans based on a mixed 0-1 integer programming model. An operation precedence graph is used to represent precedence constraints and help generate a feasible initial population of hybrid genetic algorithm. Encoding strategy based on data structure was developed to represent process plans digitally in order to form the solution space. In addition, a local search approach for optimizing the assignments of available turrets would be added to incorporate scheduling with process planning. A real-world case is used to prove that the proposed approach could avoid infeasible solutions and effectively generate a global optimal process plan.

  11. Corrective Action Investigation Plan for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage, Nevada Test Site, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    1999-01-01

    This Corrective Action Investigation Plan (CAIP) has been developed in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the US Department of Energy, Nevada Operations Office (DOE/NV); the State of Nevada Division of Environmental Protection (NDEP); and the US Department of Defense (FFACO, 1996). The CAIP is a document that provides or references all of the specific information for investigation activities associated with Corrective Action Units (CAUs) or Corrective Action Sites (CASs). According to the FFACO (1996), CASs are sites potentially requiring corrective action(s) and may include solid waste management units or individual disposal or release sites. A CAU consists of one or more CASs grouped together based on geography, technical similarity, or agency responsibility for the purpose of determining corrective actions. This CAIP contains the environmental sample collection objectives and the criteria for conducting site investigation activities at the CAU 321 Area 22 Weather Station Fuel Storage, CAS 22-99-05 Fuel Storage Area. For purposes of this discussion, this site will be referred to as either CAU 321 or the Fuel Storage Area. The Fuel Storage Area is located in Area 22 of the Nevada Test Site (NTS). The NTS is approximately 105 kilometers (km) (65 miles[mi]) northwest of Las Vegas, Nevada (Figure 1-1) (DOE/NV, 1996a). The Fuel Storage Area (Figure 1-2) was used to store fuel and other petroleum products necessary for motorized operations at the historic Camp Desert Rock facility which was operational from 1951 to 1958 at the Nevada Test Site, Nevada. The site was dismantled after 1958 (DOE/NV, 1996a)

  12. Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 398: Area 25 Spill Sites, Nevada Test Site, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    K. B. Campbell

    2001-01-01

    This Streamlined Approach for Environmental Restoration (SAFER) plan addresses the activities necessary to close Corrective Action Unit (CAU) 398: Area 25 Spill Sites. CAU 398, located in Area 25 of the Nevada Test Site, is currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO) (FFACO, 1996), and consists of the following 13 Corrective Action Sites (CASs) (Figure 1): (1) CAS 25-44-01 , a fuel spill on soil that covers a concrete pad. The origins and use of the spill material are unknown, but the spill is suspected to be railroad bedding material. (2) CAS 25-44-02, a spill of liquid to the soil from leaking drums. (3) CAS 25-44-03, a spill of oil from two leaking drums onto a concrete pad and surrounding soil. (4) CAS 25-44-04, a spill from two tanks containing sulfuric acid and sodium hydroxide used for a water demineralization process. (5) CAS 25-25-02, a fuel or oil spill from leaking drums that were removed in 1992. (6) CAS 25-25-03, an oil spill adjacent to a tipped-over drum. The source of the drum is not listed, although it is noted that the drum was removed in 1991. (7) CAS 25-25-04, an area on the north side of the Engine-Maintenance, Assembly, and Disassembly (E-MAD) facility, where oils and cooling fluids from metal machining operations were poured directly onto the ground. (8) CAS 25-25-05, an area of oil and/or hydraulic fluid spills beneath the heavy equipment once stored there. (9) CAS 25-25-06, an area of diesel fuel staining beneath two generators that have since been removed. (10) CAS 25-25-07, an area of hydraulic oil spills associated with a tunnel-boring machine abandoned inside X-Tunnel. (11) CAS 25-25-08, an area of hydraulic fluid spills associated with a tunnel-boring machine abandoned inside Y-Tunnel. (12) CAS 25-25-16, a diesel fuel spill from an above-ground storage tank located near Building 3320 at Engine Test Stand-1 (ETS-1) that was removed in 1998. (13) CAS 25-25-17, a hydraulic oil spill

  13. Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca.

    Science.gov (United States)

    Izci, Celal; Celik, Ilhami; Alkan, Fahrettin; Ogurtan, Zeki; Ceylan, Cengiz; Sur, Emrah; Ozkan, Yasemin

    2002-05-01

    To evaluate the efficacy of topical administration of a 2% solution of cyclosporine (CsA) for treatment of dogs with keratoconjunctivitis sicca (KCS) and to correlate results with histopathologic characteristics and local cellular immunity of the gland of the third eyelid. 24 dogs with bilateral KCS. Lacrimal secretion was measured, using Schirmer tear test (STT) strips. Leukocyte and T-lymphocyte subsets were determined in blood samples. Histopathologic changes as well as CD4+, CD8+, and alpha-naphthyl-acetate esterase-positive (ANAE+) lymphocytes were evaluated. Clinical signs resolved at the end of 1 month in conjunction with significantly increased STT values, compared with baseline values. Fifteen and 30 days after discontinuation of CsA treatment, a decrease was observed in STT values in both eyes; however, only values for the right eye were significantly different. There was a significant decrease in the number of lymphocytes and ANAE+ lymphocytes 15 and 30 days after discontinuation of CsA treatment, compared with baseline values. Differences were not observed in number of CD4+ lymphocytes among treatment groups. However, there was a significant decrease in number of CD8+ lymphocytes with reversal of the CD4+:CD8+ in both eyes after CsA treatment for 30 days, compared with the control group. Increased secretory activity and decreased lymphocyte infiltration were characteristic histopathologic findings. Topical administration of a 2% solution of CsA was effective for the treatment of dogs with KCS. Strict follow-up monitoring is required after the cessation of treatment because of the possibility of recurrence of KCS.

  14. Local development strategies for inner areas in Italy. A comparative analysis based on plan documents

    Directory of Open Access Journals (Sweden)

    Gabriella Punziano

    2016-12-01

    Full Text Available Within the huge literature on local development policies produced across different disciplines, comparatively little attention has been paid to an important element as relevant as economic, financial and social capital: the cognitive element, needed in strategic thinking and complexity management, the “collective brain” guiding the decision-making process. In this paper, we investigate what we consider a direct “proxy” for this variable, which is supposed to incorporate that “usable knowledge” assisting those making policy choices: language. Language shapes the way problems are conceived, fixes priorities and delimits the range of strategic options. More specifically, our research question inquires which contextual factors are at stake in local development strategy design. The case studies were chosen among the pilot areas included in the Italian “National Strategy for Inner Areas”. Through a multidimensional content analysis of the plan documents available online, we explored the ways in which development strategies are locally interpreted. The techniques we used allowed us to make a comparative analysis, testing three effects that could have influenced local policy design: a geographical effect, a concept/policy transfer effect, and a framing effect. Broader, interesting reflections were drawn from research findings on the local embedded ability to designing consistent and effective development strategies.

  15. Learning topics in urban planning at UFMG:Geoprocessing to support analysis, planning and proposal of the urban landscape at neighborhood scale

    Directory of Open Access Journals (Sweden)

    Ana Clara Mourão Moura

    2012-12-01

    Full Text Available Relata experiência de treinamento de alunos em geotecnologias para apoio a processos de análise, planejamento, e proposição de paisagens urbanas em escala local, usando Análise de Multicritérios para identificação de potencialidades, vocações e conflitos de interesse no uso do solo. São construídas sínteses de interesse ambiental, de adensamento urbano, e de conflitos de interesse. A representação tridimensional do território é para apoio à proposição do zoneamento. Os alunos atuam de modo mais consciente quando projetam, usando estudos preditivos para a paisagem, pois conseguem visualizar as consequencias das proposições para o espaço urbano e observar as consequências sobre as mudanças climáticas.

  16. AGRICULTURAL DEVELOPMENT PLANNING BASED ON LOCAL RESOURCES IN DEPOK CITY, INDONESIA

    Directory of Open Access Journals (Sweden)

    Abdurahim A.

    2018-01-01

    Full Text Available The background of this study is that Dewa Starfruit as a local resource in Depok City is threatened with extinction. The absence of regulations that protect these local resources and high rate of land use conversion causes decreasing number of starfruit plants and production. Starfruit farmers tend to switch professions to non-agricultural occupations. In national level, the largest number of agricultural business households experienced the greatest decline in horticulture subsector by 37.4% (Agricultural Census 2013. The elected regional head has branded Depok City with the tagline "friendly city" replacing Dewa Starfruit. The government's orientation and support for Dewa starfruit is fading away. Therefore, Depok City Government, especially DKP3, need to develop local resource-based agriculture development plan in order to be able to maintain local resources while improving it for society welfare. This research uses qualitative approach. The research informants were DKP3 apparatus of Depok City, Bappeda (Regional Government apparatus of Depok City, field officer and farmer group. Data collection techniques used in-depth interviews and documentary studies. Data analysis utilized interactive model. Research results indicate that the development of local resource-based agricultural development plans has not gone well. Despite various supporting factors, there are existing inhibiting factors which are land use conversion had never been discussed; DKP3 Depok City efforts to safeguard agricultural issues in musrenbang has not been optimal; no field data update, either by couseling workers or farmers; DKP3 Depok City prioritized RPL activity; uneducated farmers; and absence of regional head support.

  17. Rank aggregation of local expert knowledge for conservation planning of the critically endangered saola.

    Science.gov (United States)

    Wilkinson, Nicholas M; Van Duc, Luong

    2017-06-01

    There has been much recent interest in using local knowledge and expert opinion for conservation planning, particularly for hard-to-detect species. Although it is possible to ask for direct estimation of quantities such as population size, relative abundance is easier to estimate. However, an expert's knowledge is often geographically restricted relative to the area of interest. Combining (or aggregating) experts' assessments of relative abundance is difficult when each expert only knows a part of the area of interest. We used Google's PageRank algorithm to aggregate ranked abundance scores elicited from local experts through a rapid rural-appraisal method. We applied this technique to conservation planning for the saola (Pseudoryx nghetinhensis), a poorly known bovid. Near a priority landscape for the species, composed of 3 contiguous protected areas, we asked groups of local people to indicate relative abundances of saola and other species by placing beans on community maps. For each village, we used this information to rank areas within the knowledge area of that village for saola abundance. We used simulations to compare alternative methods to aggregate the rankings from the different villages. The best-performing method was then used to produce a single map of relative abundance across the entire landscape, an area larger than that known to any one village. This map has informed prioritization of surveys and conservation action in the continued absence of direct information about the saola. © 2016 Society for Conservation Biology.

  18. Testosterone Topical

    Science.gov (United States)

    ... not apply any testosterone topical products to your penis or scrotum or to skin that has sores, ... are severe or do not go away: breast enlargement and/or pain decreased sexual desire acne depression ...

  19. Evaluation of natural factors in town planning and strategic programming of development local community

    Directory of Open Access Journals (Sweden)

    Lješević Milutin

    2009-01-01

    Full Text Available The natural components are very important aspect of human life and work. The nature is place is place wherever to happened majority of human activity, working vacation and survival, although are some areas is technicality and desecrating to denaturalization. Because of that, it is necessary to study all valid of natural factors, when to programs new contents which are in function of human living, work or holiday. We can find great differences in exploration of some natural factors depending of level in programming of development (general or detail urban planning and strategic programming or local community or projecting. .

  20. Impact on local air quality of the planned fixed link across Oresund

    DEFF Research Database (Denmark)

    Fenger, Jes; Vignati, Elisabetta; Berkowicz, Ruwim

    1996-01-01

    The planned combined bridge and tunnel link between Sweden and Denmark (the Oresund Link) is expected to be in operation around the turn of the century. So far the impacts of the Oresund Link on air pollution have been discussed mainly in terms of changes in emissions, taking into account...... implications of the link on traffic in the region. It appears that the influence on regional and global air pollution will be marginal. Concerning local effects however, the situation is different; the new link across the Oresund and the island Amager will result in significant changes in traffic pattern...

  1. Seismic micro-zoning in the alpine valleys and local application in urban planning regulations

    Directory of Open Access Journals (Sweden)

    Stéphane Cartier

    2009-03-01

    Full Text Available Confrontées au risque sismique, les vallées sédimentaires alpines testent différentes solutions politiques pour transcrire en règles d’urbanisme les connaissances apportées par les micro-zonages. France, Italie, Slovénie et Suisse composent avec leur tradition politique et l’adoption de codes européens pour améliorer la sécurité selon la vulnérabilité et la géologie locales.Management of earthquake risks in the sedimentary valleys of the Alps depends on the ability to transcribe scientific knowledge obtained from micro-zoning into urban planning regulations. France, Italy, Slovenia and Switzerland are working with new European codes, and within their respective political contexts, to improve earthquake safety on the basis of enhanced input on local geological conditions and vulnerability levels.

  2. 3D Geovisualization & Stylization to Manage Comprehensive and Participative Local Urban Plans

    Science.gov (United States)

    Brasebin, M.; Christophe, S.; Jacquinod, F.; Vinesse, A.; Mahon, H.

    2016-10-01

    3D geo-visualization is more and more used and appreciated to support public participation, and is generally used to present predesigned planned projects. Nevertheless, other participatory processes may benefit from such technology such as the elaboration of urban planning documents. In this article, we present one of the objectives of the PLU++ project: the design of a 3D geo-visualization system that eases the participation concerning local urban plans. Through a pluridisciplinary approach, it aims at covering the different aspects of such a system: the simulation of built configurations to represent regulation information, the efficient stylization of these objects to make people understand their meanings and the interaction between 3D simulation and stylization. The system aims at being adaptive according to the participation context and to the dynamic of the participation. It will offer the possibility to modify simulation results and the rendering styles of the 3D representations to support participation. The proposed 3D rendering styles will be used in a set of practical experiments in order to test and validate some hypothesis from past researches of the project members about 3D simulation, 3D semiotics and knowledge about uses.

  3. Topical Research: Africa.

    Science.gov (United States)

    Lynn, Karen

    This lesson plan can be used in social studies, language arts, or library research. The instructional objective is for students to select a topic of study relating to Africa, write a thesis statement, collect information from media sources, and develop a conclusion. The teacher may assign the lesson for written or oral evaluation. The teacher…

  4. Locally advanced pancreatic duct adenocarcinoma: pancreatectomy with planned arterial resection based on axial arterial encasement.

    Science.gov (United States)

    Perinel, J; Nappo, G; El Bechwaty, M; Walter, T; Hervieu, V; Valette, P J; Feugier, P; Adham, M

    2016-12-01

    Pancreatectomy with arterial resection for locally advanced pancreatic duct adenocarcinoma (PDA) is associated with high morbidity and is thus considered as a contraindication. The aim of our study was to report our experience of pancreatectomy with planned arterial resection for locally advanced PDA based on specific selection criteria. All patients receiving pancreatectomy for PDA between October 2008 and July 2014 were reviewed. The patients were classified into group 1, pancreatectomy without vascular resection (66 patients); group 2, pancreatectomy with isolated venous resection (31 patients), and group 3, pancreatectomy with arterial resection for locally advanced PDA (14 patients). The primary selection criteria for arterial resection was the possibility of achieving a complete resection based on the extent of axial encasement, the absence of tumor invasion at the origin of celiac trunk (CT) and superior mesenteric artery (SMA), and a free distal arterial segment allowing reconstruction. Patient outcomes and survival were analyzed. Six SMA, two CT, four common hepatic artery, and two replaced right hepatic artery resections were undertaken. The preferred arterial reconstruction was splenic artery transposition. Group 3 had a higher preoperative weight loss, a longer operative time, and a higher incidence of intraoperative blood transfusion. Ninety-day mortality occurred in three patients in groups 1 and 2. There were no statistically significant differences in the incidence, grade, and type of complications in the three groups. Postoperative pancreatic fistula and postpancreatectomy hemorrhage were also comparable. In group 3, none had arterial wall invasion and nine patients had recurrence (seven metastatic and two loco-regional). Survival and disease-free survival were comparable between groups. Planned arterial resection for PDA can be performed safely with a good outcome in highly selected patients. Key elements for defining the resectability is based on

  5. Localization of the prostatic apex using CT for radiation treatment planning

    International Nuclear Information System (INIS)

    Li Xiaomei; Gao Xianshu; Guo Xuemei; Li Yagang; Wang Xiaoying

    2011-01-01

    Objective: In this retrospective study, we analyzed the magnetic resonance imaging (MRI) and computed tomography (CT) scans of patients with prostate cancer to investigate the relationship between the apex of prostate and the anatomic structures visible in CT, and to provide evidence for localizing the prostatic apex in radiation treatment planning. Methods: MRI and CT scans from 108 patients with prostate cancer were analyzed to measure the distance between the prostatic apex and the bottom of ischial tuberosities, the bottom of obturator foramen, the bottom of pubic symphysis and the bulb of the penis. The volume of prostate was calculated and the relationship between the size of the prostate and the localization of the prostatic apex was analyzed. Results: The prostatic apex is located 13.1 mm ± 3.3 mm superior to the bulb of the penis, 11.0 mm ± 5.4 mm superior to the bottom of obturator foramen, 31.3 mm ± 5.5 mm superior to the bottom of ischial tuberosities, and 7.1 mm ± 4.7 mm superior to the bottom of obturator foramen. There was no correlation between the size of prostate and the localization of the prostatic apex (R =0.07, -0.33, all P > 0.05). Conclusions: Ninety-five percent of patients had a prostatic apex that is above the bulb of the penis 6 mm, and 100% of patients had a prostatic apex that is above the bottom of obturator foramen. (authors)

  6. Starting a local conservation and passive solar retrofit program: an energy planning sourcebook

    Energy Technology Data Exchange (ETDEWEB)

    Barber, V; Mathews, R

    1982-02-01

    A city planner or a neighborhood activist may wish to initiate a local conservation and passive solar retrofit program but may not have previous experience in doing so. This sourcebook is designed to assist interested individuals with their energy planning efforts, from determining retrofit potential, to financing and implementing the program. An approach or methodology is provided which can be applied to determine retrofit potential in single-family residences, mobile homes, multifamily residences, and nonresidential buildings. Case studies in Albuquerque, New Mexico, are given as examples. Guidelines are provided for evaluating the economic benefits of a retrofit program through benefit-cost analysis and economic base studies at the city and neighborhood levels. Also included are approaches to community outreach, detailing how to get started, how to gain local support, and examples of successful programs throughout the US. The need for financing, the development of a local strategy, public and private financing techniques, and community energy service organizations are examined. In addition to the Albuquerque case studies, a brief technology characterization, heat-loss calculations, economic tools, and a list of resources are appended.

  7. Bimatoprost Topical

    Science.gov (United States)

    ... not use a cotton swab or any other brush or applicator to apply topical bimatoprost.To use the solution, follow these steps: Wash your hands and face thoroughly with soap and water. Be sure that all makeup is removed. Do not let the tip of ...

  8. European recommendations for primary prevention of congenital anomalies: a joined effort of EUROCAT and EUROPLAN projects to facilitate inclusion of this topic in the National Rare Disease Plans.

    Science.gov (United States)

    Taruscio, Domenica; Arriola, Larraitz; Baldi, Francesca; Barisic, Ingeborg; Bermejo-Sánchez, Eva; Bianchi, Fabrizio; Calzolari, Elisa; Carbone, Pietro; Curran, Rhonda; Garne, Ester; Gatt, Miriam; Latos-Bieleńska, Anna; Khoshnood, Babak; Irgens, Lorentz; Mantovani, Alberto; Martínez-Frías, Maria Luisa; Neville, Amanda; Rißmann, Anke; Ruggeri, Stefania; Wellesley, Diana; Dolk, Helen

    2014-01-01

    Congenital anomalies (CA) are the paradigm example of rare diseases liable to primary prevention actions due to the multifactorial etiology of many of them, involving a number of environmental factors together with genetic predispositions. Yet despite the preventive potential, lack of attention to an integrated preventive strategy has led to the prevalence of CA remaining relatively stable in recent decades. The 2 European projects, EUROCAT and EUROPLAN, have joined efforts to provide the first science-based and comprehensive set of recommendations for the primary prevention of CA in the European Union. The resulting EUROCAT-EUROPLAN 'Recommendations on Policies to Be Considered for the Primary Prevention of Congenital Anomalies in National Plans and Strategies on Rare Diseases' were issued in 2012 and endorsed by EUCERD (European Union Committee of Experts on Rare Diseases) in 2013. The recommendations exploit interdisciplinary expertise encompassing drugs, diet, lifestyles, maternal health status, and the environment. The recommendations include evidence-based actions aimed at reducing risk factors and at increasing protective factors and behaviors at both individual and population level. Moreover, consideration is given to topics specifically related to CA (e.g. folate status, teratogens) as well as of broad public health impact (e.g. obesity, smoking) which call for specific attention to their relevance in the pre- and periconceptional period. The recommendations, reported entirely in this paper, are a comprehensive tool to implement primary prevention into national policies on rare diseases in Europe. © 2014 S. Karger AG, Basel.

  9. Role of image-guided patient repositioning and online planning in localized prostate cancer IMRT

    International Nuclear Information System (INIS)

    Lerma, Fritz A.; Liu, Bei; Wang, Zhendong; Yi, Byongyong; Amin, Pradip; Liu, Sandy; Feng Yuanming; Yu, Cedric X.

    2009-01-01

    Purpose: To determine the expected benefit of image-guided online replanning over image-guided repositioning of localized prostate cancer intensity-modulated radiotherapy (IMRT). Materials and methods: On 10 to 11 CT scans of each of 10 early-stage prostate cancer patients, the prostate, bladder and rectum are manually segmented. Using a 3-mm PTV margin expansion from the CTV, an IMRT plan is made on the first CT scan of each patient. Online repositioning is simulated by recalculating the IMRT plan from the initial CT scan on the subsequent CT scans of each patient. For online replanning, IMRT is replanned twice on all CT scans, using 0-mm and 3-mm margins. The doses from subsequent CT images of each patient are then deformed to the initial CT anatomy using a mesh-based thin-plate B-spline deformation method and are accumulated for DVH and isodose review. Results: Paired t-tests show that online replanning with 3-mm margins significantly increases the prostate volume receiving the prescribed dose over replanning with 0-mm margins (p-value 0.004); gives marginally better target coverage than repositioning with 3-mm margins(p-value 0.06-0.343), and reduces variations in target coverage over repositioning. Fractional volumes of rectum and bladder receiving 75%, 80%, 85%, 90%, and 95% (V75, V80, V85, V90, and V95) of the prescription dose are evaluated. V90 and V95 values for the rectum are 1.6% and 0.7 % for 3-mm margin replanning and 1% and 0.4 % for 0-mm margin replanning, with p-values of 0.010-0.011. No significant differences between repositioning and replanning with 3-mm margins are found for both the rectum and the bladder. Conclusions: Image-guided replanning using 3-mm margins reduces target coverage variations, and maintains comparable rectum and bladder sparing to patient repositioning in localized prostate cancer IMRT. Marginal reductions in doses to rectum and bladder are possible when planning margins are eliminated in the online replanning scenario

  10. An audit of local government planning tools for their potential use in addressing community food and nutrition issues.

    Science.gov (United States)

    Good, Elizabeth; Hammond, Melinda; Martin, Caroline; Burns, Catherine; Groos, Anita

    2010-04-01

    This project aimed to identify how local government planning tools could be used to influence physical and policy environments to support healthy eating behaviours in communities. An audit of Queensland's legislative and non-legislative local government planning tools was conducted by a public health nutritionist to assess their potential use in addressing strategies to achieve positive nutrition outcomes. Ten strategies were identified and covered the following themes: improving access to healthy foods and drinks; increasing access to breastfeeding facilities; decreasing fast food outlet density; and unhealthy food advertising. The audit found that all of the 10 strategies to achieve positive nutrition outcomes could be considered through three or more of the planning tools. Based on the findings of this audit, local government planning tools provide opportunities to address food and nutrition issues and contribute toward creating physical and policy environments that support healthy eating behaviours.

  11. Constrained VPH+: a local path planning algorithm for a bio-inspired crawling robot with customized ultrasonic scanning sensor.

    Science.gov (United States)

    Rao, Akshay; Elara, Mohan Rajesh; Elangovan, Karthikeyan

    This paper aims to develop a local path planning algorithm for a bio-inspired, reconfigurable crawling robot. A detailed description of the robotic platform is first provided, and the suitability for deployment of each of the current state-of-the-art local path planners is analyzed after an extensive literature review. The Enhanced Vector Polar Histogram algorithm is described and reformulated to better fit the requirements of the platform. The algorithm is deployed on the robotic platform in crawling configuration and favorably compared with other state-of-the-art local path planning algorithms.

  12. Improving oncoplastic breast tumor bed localization for radiotherapy planning using image registration algorithms

    Science.gov (United States)

    Wodzinski, Marek; Skalski, Andrzej; Ciepiela, Izabela; Kuszewski, Tomasz; Kedzierawski, Piotr; Gajda, Janusz

    2018-02-01

    Knowledge about tumor bed localization and its shape analysis is a crucial factor for preventing irradiation of healthy tissues during supportive radiotherapy and as a result, cancer recurrence. The localization process is especially hard for tumors placed nearby soft tissues, which undergo complex, nonrigid deformations. Among them, breast cancer can be considered as the most representative example. A natural approach to improving tumor bed localization is the use of image registration algorithms. However, this involves two unusual aspects which are not common in typical medical image registration: the real deformation field is discontinuous, and there is no direct correspondence between the cancer and its bed in the source and the target 3D images respectively. The tumor no longer exists during radiotherapy planning. Therefore, a traditional evaluation approach based on known, smooth deformations and target registration error are not directly applicable. In this work, we propose alternative artificial deformations which model the tumor bed creation process. We perform a comprehensive evaluation of the most commonly used deformable registration algorithms: B-Splines free form deformations (B-Splines FFD), different variants of the Demons and TV-L1 optical flow. The evaluation procedure includes quantitative assessment of the dedicated artificial deformations, target registration error calculation, 3D contour propagation and medical experts visual judgment. The results demonstrate that the currently, practically applied image registration (rigid registration and B-Splines FFD) are not able to correctly reconstruct discontinuous deformation fields. We show that the symmetric Demons provide the most accurate soft tissues alignment in terms of the ability to reconstruct the deformation field, target registration error and relative tumor volume change, while B-Splines FFD and TV-L1 optical flow are not an appropriate choice for the breast tumor bed localization problem

  13. A Toolkit Modeling Approach for Sustainable Forest Management Planning: Achieving Balance between Science and Local Needs

    Directory of Open Access Journals (Sweden)

    Brian R. Sturtevant

    2007-12-01

    Full Text Available To assist forest managers in balancing an increasing diversity of resource objectives, we developed a toolkit modeling approach for sustainable forest management (SFM. The approach inserts a meta-modeling strategy into a collaborative modeling framework grounded in adaptive management philosophy that facilitates participation among stakeholders, decision makers, and local domain experts in the meta-model building process. The modeling team works iteratively with each of these groups to define essential questions, identify data resources, and then determine whether available tools can be applied or adapted, or whether new tools can be rapidly created to fit the need. The desired goal of the process is a linked series of domain-specific models (tools that balances generalized "top-down" models (i.e., scientific models developed without input from the local system with case-specific customized "bottom-up" models that are driven primarily by local needs. Information flow between models is organized according to vertical (i.e., between scale and horizontal (i.e., within scale dimensions. We illustrate our approach within a 2.1 million hectare forest planning district in central Labrador, a forested landscape where social and ecological values receive a higher priority than economic values. However, the focus of this paper is on the process of how SFM modeling tools and concepts can be rapidly assembled and applied in new locations, balancing efficient transfer of science with adaptation to local needs. We use the Labrador case study to illustrate strengths and challenges uniquely associated with a meta-modeling approach to integrated modeling as it fits within the broader collaborative modeling framework. Principle advantages of the approach include the scientific rigor introduced by peer-reviewed models, combined with the adaptability of meta-modeling. A key challenge is the limited transparency of scientific models to different participatory groups

  14. Global and Local Path Planning Study in a ROS-Based Research Platform for Autonomous Vehicles

    Directory of Open Access Journals (Sweden)

    Pablo Marin-Plaza

    2018-01-01

    Full Text Available The aim of this work is to integrate and analyze the performance of a path planning method based on Time Elastic Bands (TEB in real research platform based on Ackermann model. Moreover, it will be proved that all modules related to the navigation can coexist and work together to achieve the goal point without any collision. The study is done by analyzing the trajectory generated from global and local planners. The software prototyping tool is Robot Operating System (ROS from Open Source Robotics Foundation and the research platform is the iCab (Intelligent Campus Automobile from University Carlos III. This work has been validated from a test inside the campus where the iCab has performed the navigation between the starting point and the goal point without any collision. During the experiment, we proved the low sensitivity of the TEB method to variations of the vehicle model configuration and constraints.

  15. [Planned neck dissection in the treatment of locally advanced head and neck squamous cell carcinoma].

    Science.gov (United States)

    Jiang, L; Lou, J L; Wang, K J; Fang, M Y; Fu, Z F

    2018-02-07

    Objective: To investigate the value of planned neck dissection combined with induction chemotherapy and concurrent chemoradiotherapy in regional control and the outcome of locally advanced head and neck squamous cell carcinoma. Methods: A prospective randomized controlled study totally enrolled sixty-four patients of head and neck squamous cell carcinomas(include oropharynx, hypopharynx, and larynx) in stages Ⅳa-Ⅳb with lymph node metastase was were N2-N3. All patients firstly received 2-3 cycles of induction chemotherapy(ICT), then divided into two groups randomly, according to the efficacy of ICT. Group A(the study group) received planned neck dissection(PND) and concurrent chemoradiotherapy(CCRT). Group B(the control group) received concurrent chemoradiotherapy(CCRT). The differences in clinicopathologic features, local recurrence(LR), regional recurrence(RR), disease-free survival(DFS), and overall survival(OS) between the two groups were estimated. SPSS 19.0 software was used to analyze the data. Results: Group A enrolled twenty-one patients, and group B enrolled forty-three patients.The follow-up of all patients were 4-55 months, median follow-up time was 22 months. In study group, two-year OS and DFS were 80.9% and 68.3%, respectively. In control group, two-year OS and DFS were 90.7% and 67.1%, respectively. There was no significant difference in gender( P =0.215), age( P =0.828), primary tumor site( P =0.927), LR( P =0.126), DFS( P =0.710), and OS( P =0.402) between the two groups, while the RR(χ(2)=5.640, P squamous cell carcinoma.

  16. A Sustainable City Planning Algorithm Based on TLBO and Local Search

    Science.gov (United States)

    Zhang, Ke; Lin, Li; Huang, Xuanxuan; Liu, Yiming; Zhang, Yonggang

    2017-09-01

    Nowadays, how to design a city with more sustainable features has become a center problem in the field of social development, meanwhile it has provided a broad stage for the application of artificial intelligence theories and methods. Because the design of sustainable city is essentially a constraint optimization problem, the swarm intelligence algorithm of extensive research has become a natural candidate for solving the problem. TLBO (Teaching-Learning-Based Optimization) algorithm is a new swarm intelligence algorithm. Its inspiration comes from the “teaching” and “learning” behavior of teaching class in the life. The evolution of the population is realized by simulating the “teaching” of the teacher and the student “learning” from each other, with features of less parameters, efficient, simple thinking, easy to achieve and so on. It has been successfully applied to scheduling, planning, configuration and other fields, which achieved a good effect and has been paid more and more attention by artificial intelligence researchers. Based on the classical TLBO algorithm, we propose a TLBO_LS algorithm combined with local search. We design and implement the random generation algorithm and evaluation model of urban planning problem. The experiments on the small and medium-sized random generation problem showed that our proposed algorithm has obvious advantages over DE algorithm and classical TLBO algorithm in terms of convergence speed and solution quality.

  17. 15 local climate-energy plans: regions and districts, local leaders of the struggle against climate change

    International Nuclear Information System (INIS)

    2009-01-01

    This report presents some general information, the sectors addressed by the Climate - Energy Plan, the approaches adopted, the plan elaboration process (organisation, participation and governance, diagnosis and challenges identification, communication actions), the actions and their follow-up, the success factors and the improvement opportunities of the Climate-energy Plans elaborated and adopted by different French regions (Alsace, Aquitaine, Basse-Normandie, Champagne-Ardenne, Franche-Comte, Haute-Normandie, Languedoc-Roussillon, Limousin, Nord-Pas-de-Calais, Poitou-Charentes) and districts (Alpes Maritimes, Bas-Rhin, Eure, Seine-Maritime)

  18. A treatment planning comparison of four target volume contouring guidelines for locally advanced pancreatic cancer radiotherapy

    International Nuclear Information System (INIS)

    Fokas, Emmanouil; Eccles, Cynthia; Patel, Neel; Chu, Kwun-Ye; Warren, Samantha; McKenna, W. Gillies; Brunner, Thomas B.

    2013-01-01

    Background and purpose: Contouring of target volumes varies significantly in radiotherapy of pancreatic ductal adenocarcinoma (PDAC). There is a lack of consensus as to whether elective lymph nodes (eLN’s) should be included or not in the planning target volume (PTV). In the present study we analyzed the dosimetric coverage of the eLN’s and organs at risk (OAR) by comparing four different contouring guidelines. Methods and materials: PTVs were delineated with (Oxford and RTOG guidelines) or without (Michigan and SCALOP guidelines) including the eLNs in eleven patients with PDAC. eLNs included the peripancreatic, paraaortic, paracaval, celiac trunk, superior mesenteric and portal vein clinical target volumes (CTVs). A 3D-CRT plan (50.40 Gy in 28 fractions) was performed to analyze and compare the dosimetric coverage of all eLNs and OAR between the 4 contouring guidelines. Results: The size of Oxford and RTOG PTVs was comparable and significantly larger than the SCALOP and Michigan PTVs. Interestingly the eLNs received a significant amount of incidental dose irradiation by PTV-based plans that only aimed to treat the tumor without the eLNs. The dosimetric coverage of eLN presented a large variability according to the respective contouring methods. The difference in the size of the 4 PTVs was reflected to the dose distribution at the OAR. Conclusions: Our study provides important information regarding the impact of different contouring guidelines on the dose distribution to the eLNs and the OAR in patients with locally advanced PDAC treated with radiotherapy

  19. Metropolization Process for enhancing local and regional planning : an experience of cirebon metropolitan, West Java

    Science.gov (United States)

    Supriyadi Rustidja, E.

    2018-03-01

    Metropolitan develops in line with resource utilization, investment, and transactions of regional activities. Metropolization of an area gives emerge urban economy that changes the situation, form, and pattern of urban space interactions. On the other hand, metropolism concerns the strategy of changing variation of urban space, so that metropolitan invasion not only form of urban space but also the process of interaction among stakeholders in developing metropolitan area. Based on participatory research, this article explores metropolitan invasion process for enhancing local and regional planning, both indigenous and intrusive cataclysmic. The study find that the primeval, rural, and urban as elemental environment must be considered in developing metropolitan, not merely form the structure and pattern of urban space. The metropolization process also requires the strategic of rural urban linkage, context setting and local assessment, strategic community investment, and interculturalist approach. The other findings of the study show that metropolization in Cirebon Metropolitan, West Java emphasizing on promotion of competitiveness strategy, value chain urban activities, and networking of urban areas. Cirebon Metropolitan must promote the realization of growth centers and connect the interregional activities of metropolitan area for providing sustainable economic growth.

  20. A neighborhood susceptibility index for planning of local physical interventions in response to pandemic influenza outbreaks

    Science.gov (United States)

    Timpka, Toomas; Eriksson, Henrik; Strömgren, Magnus; Eriksson, Olle; Ekberg, Joakim; Grimvall, Anders; Nyce, James; Gursky, Elin; Holm, Einar

    2010-01-01

    The global spread of a novel A (H1N1) influenza virus in 2009 has highlighted the possibility of a devastating pandemic similar to the ‘Spanish flu’ of 1917–1918. Responding to such pandemics requires careful planning for the early phases where there is no availability of pandemic vaccine. We set out to compute a Neighborhood Influenza Susceptibility Index (NISI) describing the vulnerability of local communities of different geo-socio-physical structure to a pandemic influenza outbreak. We used a spatially explicit geo-physical model of Linköping municipality (pop. 136,240) in Sweden, and employed an ontology-modeling tool to define simulation models and transmission settings. We found considerable differences in NISI between neighborhoods corresponding to primary care areas with regard to early progress of the outbreak, as well as in terms of the total accumulated share of infected residents counted after the outbreak. The NISI can be used in local preparations of physical response measures during pandemics. PMID:21347087

  1. Selected Economic Aspects Of Adopting A Local Spatial Development Plan Exemplified By The Commune Of Tomice In Malopolskie Province

    Directory of Open Access Journals (Sweden)

    Gawroński Krzysztof

    2015-12-01

    Full Text Available The object of this article is to analyze and asses the legal and economic consequences arising from the adoption (or change of a local spatial development plan. The paper also presents, based on the example of the rural commune of Tomice in the Malopolska Province of Poland, how to estimate income to the commune budget from the collected planning fees. The analyses are based on planning studies, including the local spatial development plan from 2004, and the study of conditions and directions of spatial development from 2012. The council of Tomice Commune adopted the local spatial plan due to the increasing demand for residential areas. According to the plan, over 930 acres of land have been allocated for investment purposes, which is approx. 22.4% of the total area of 4,155 ha. The local plan was developed for all the six cadastral units of the commune, with one hundred percent surface coverage. The physiographic conditions and the location of Tomice Commune encourage the settlement of the urban population (from Wadowice or Krakow, which entails the need for housing investment areas. In 2012, the Tomice Commune adopted a change in the study of conditions and directions of spatial development. The proposed re-zoning of the area is in line with the policy of transitioning from an agricultural character towards the sustainable and multifunctional development of the commune. It is worth noting that the provisions of the plan of 2004 take into account the collection of a one-time fee for the sale of real estate whose value has increased as a result of the adoption of the plan. The amount of this fee for investment areas was set at the level of 30% of the increase in value, in accordance with the provisions of the Polish Act on Spatial Planning and Management. Due to the fact that the currently valid local plan has been in effect for 10 years, it can be assumed that the commune will proceed to make some changes to it. The article estimates the

  2. Adaptive local learning in sampling based motion planning for protein folding.

    Science.gov (United States)

    Ekenna, Chinwe; Thomas, Shawna; Amato, Nancy M

    2016-08-01

    Simulating protein folding motions is an important problem in computational biology. Motion planning algorithms, such as Probabilistic Roadmap Methods, have been successful in modeling the folding landscape. Probabilistic Roadmap Methods and variants contain several phases (i.e., sampling, connection, and path extraction). Most of the time is spent in the connection phase and selecting which variant to employ is a difficult task. Global machine learning has been applied to the connection phase but is inefficient in situations with varying topology, such as those typical of folding landscapes. We develop a local learning algorithm that exploits the past performance of methods within the neighborhood of the current connection attempts as a basis for learning. It is sensitive not only to different types of landscapes but also to differing regions in the landscape itself, removing the need to explicitly partition the landscape. We perform experiments on 23 proteins of varying secondary structure makeup with 52-114 residues. We compare the success rate when using our methods and other methods. We demonstrate a clear need for learning (i.e., only learning methods were able to validate against all available experimental data) and show that local learning is superior to global learning producing, in many cases, significantly higher quality results than the other methods. We present an algorithm that uses local learning to select appropriate connection methods in the context of roadmap construction for protein folding. Our method removes the burden of deciding which method to use, leverages the strengths of the individual input methods, and it is extendable to include other future connection methods.

  3. Multicriteria Optimization in Intensity-Modulated Radiation Therapy Treatment Planning for Locally Advanced Cancer of the Pancreatic Head

    International Nuclear Information System (INIS)

    Hong, Theodore S.; Craft, David L.; Carlsson, Fredrik; Bortfeld, Thomas R.

    2008-01-01

    Purpose: Intensity-modulated radiation therapy (IMRT) affords the potential to decrease radiation therapy-associated toxicity by creating highly conformal dose distributions. However, the inverse planning process can create a suboptimal plan despite meeting all constraints. Multicriteria optimization (MCO) may reduce the time-consuming iteration loop necessary to develop a satisfactory plan while providing information regarding trade-offs between different treatment planning goals. In this exploratory study, we examine the feasibility and utility of MCO in physician plan selection in patients with locally advanced pancreatic cancer (LAPC). Methods and Materials: The first 10 consecutive patients with LAPC treated with IMRT were evaluated. A database of plans (Pareto surface) was created that met the inverse planning goals. The physician then navigated to an 'optimal' plan from the point on the Pareto surface at which kidney dose was minimized. Results: Pareto surfaces were created for all 10 patients. A physician was able to select a plan from the Pareto surface within 10 minutes for all cases. Compared with the original (treated) IMRT plans, the plan selected from the Pareto surface had a lower stomach mean dose in 9 of 10 patients, although often at the expense of higher kidney dose than with the treated plan. Conclusion: The MCO is feasible in patients with LAPC and allows the physician to choose a satisfactory plan quickly. Generally, when given the opportunity, the physician will choose a plan with a lower stomach dose. The MCO enables a physician to provide greater active clinical input into the IMRT planning process

  4. Energy planning on local scale. Remarks on Livorno city experience; La pianificazione energetica su scala locale. Riflessioni sull`esperienza della citta` di Livorno

    Energy Technology Data Exchange (ETDEWEB)

    Butta, Renato [Comune di Livorno (Italy). Dipt. Ambiente

    1996-12-31

    The area of Municipality of Livorno is classified, by European Union Structural Funds, as an Objective 2. As all the Italian cities over 50,000 inhabitants, Livorno is requested by the national law n. 10/91, to adopt an Energy Plan and to integrate in with the local use Plan. The main tasks of the Energy Plan of Livorno are: I. Reduce or mitigate the industrial decline in the city, developing coordinated strategies in the field of production energy efficiency; II. Define guide-lines and energy indicators for the Land use Plan, focused on the residential sector. The main priorities are: reduce the environmental impact of non renewable energy sources; reduce the energy local economic costs due to energy importation; improve the economic convenience of saving projects, reducing the use of sunk capital; integrate the energy aspects in the usual administrative procedures; carry out an Information System supporting the decisional process for public and private actors. The projects planned in the scenarios are: cogeneration plant, biogas utilisation from waste landfills, gas network pressure jamp, renewable energies in public building stock, energy saving in residential building, district heating system connected with the repowered thermoelectric power plant.

  5. Calcitriol Topical

    Science.gov (United States)

    ... a treatment for psoriasis that involves exposing the skin to ultraviolet [UV] light).tell your doctor if you are pregnant, plan ... avoid unnecessary or prolonged exposure to sunlight and UV light (such as ... sunscreen. Calcitriol ointment may make your skin sensitive to sunlight.

  6. Enhancing Effective Stakeholder Participation in Local Groundwater Sustainability Planning through Technical Assistance in California

    Science.gov (United States)

    Weintraub, C.; Christian-Smith, J.; Dobbin, K.; Cullen, K.

    2017-12-01

    This presentation will share content from UCS's new publication, Getting Involved in Groundwater; A Guide to Effective Engagement in California's Groundwater Sustainability Plans, as well as lessons learned from collaborating with community organizations to provide technical assistance to Groundwater Sustainability Agency (GSA) board members and stakeholders in the San Joaquin Valley on Groundwater Sustainability Plan (GSP) development. California's Sustainable Groundwater Management Act (SGMA) mandates extensive stakeholder engagement, presenting an opportunity for unincorporated, low-income communities that have historically been affected by but not included in water decisions. However, implementation requires a concerted, thoughtful effort. Through technical assistance and strategic outreach, the Union of Concerned Scientists (UCS) is working to ensure stakeholder engagement in GSP development is robust, diverse, and supported by the best science available. UCS created the GSP stakeholder engagement guide to equip GSA members, scientists and interested community members to meaningfully engage in the GSP development process. The guide serves as a technical primer on SGMA's GSP process and as a resource for understanding groundwater management in California. The guide is just one component of a larger effort to overcome barriers to effective engagement in sustainable groundwater management, especially those presented by technical information. In April, UCS co-hosted a technical assistance workshop for GSA and advisory committee members in Visalia, CA with the Community Water Center (CWC), a local environmental justice non-profit. The workshop was well received and UCS and the CWC were invited to host a second workshop in June. To deepen this engagement and provide one-on-one technical assistance, UCS developed a program to match relevant water experts in the UCS Science Network with GSA members or involved community members in need of specific technical support

  7. Diets: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Mediterranean diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diets updates by ... foods Diet-busting foods Mediterranean diet Related Health Topics Child Nutrition DASH Eating Plan Diabetic Diet Nutrition ...

  8. Topic Modeling of Hierarchical Corpora /

    OpenAIRE

    Kim, Do-kyum

    2014-01-01

    The sizes of modern digital libraries have grown beyond our capacity to comprehend manually. Thus we need new tools to help us in organizing and browsing large corpora of text that do not require manually examining each document. To this end, machine learning researchers have developed topic models, statistical learning algorithms for automatic comprehension of large collections of text. Topic models provide both global and local views of a corpus; they discover topics that run through the co...

  9. Bio-energy in global and local policy and planning in developing countries, in particular in Africa

    International Nuclear Information System (INIS)

    Riedacker, A.

    1997-01-01

    Biomass energy is investigated from different viewpoints; in business as usual developments, in local and global perspectives trying to promote sustainable development. The objectives and the methodology are clarified. It is considered how these principles are applicable in particular in sub-Saharan Africa. Local planning and implementation is also discussed. Activities of the RABEDE, an African Network on Bio-resources and Energies for Development and Environment are presented. (K.A.)

  10. A local area network for medical research; planning, realization and experience.

    Science.gov (United States)

    Schosser, R; Weiss, C; Messmer, K

    1991-01-01

    This report focuses on the planning and realization of an interdisciplinary local area network (LAN) for medical research at the University of Heidelberg. After a detailed requirements analysis, several networks were evaluated by means of a test installation, and a cost-performance analysis was carried out. At present, the LAN connects 45 (IBM-compatible) PCs, several heterogeneous mainframes (IBM, DEC and Siemens) and provides access to the public X.25 network and to wide-area networks for research (EARN, BITNET). The network supports application software that is frequently needed in medical research (word processing, statistics, graphics, literature databases and services, etc.). Compliance with existing "official" (e.g., IEEE 802.3) and "de facto" standards (e.g., PostScript) was considered to be extremely important for the selection of both hardware and software. Customized programs were developed to improve access control, user interface and on-line help. Wide acceptance of the LAN was achieved through extensive education and maintenance facilities, e.g., teaching courses, customized manuals and a hotline service. Since requirements of clinical routine differ substantially from medical research needs, two separate networks (with a gateway in between) are proposed as a solution to optimally satisfy the users' demands.

  11. Integrated resource planning for local gas distribution companies: A critical review of regulatory policy issues

    International Nuclear Information System (INIS)

    Harunuzzaman, M.; Islam, M.

    1994-08-01

    According to the report, public utility commissions (PUCs) are increasingly adopting, or considering the adoption of integrated resource planning (IRP) for local gas distribution companies (LDCs). The Energy Policy Act of 1992 (EPAct) requires PUCs to consider IRP for gas LDCs. This study has two major objectives: (1) to help PUCs develop appropriate regulatory approaches with regard to IRP for gas LDCs; and (2) to help PUCs respond to the EPAct directive. The study finds that it is appropriate for PUCs to pursue energy efficiency within the traditional regulatory framework of minimizing private costs of energy production and delivery; and PUCs should play a limited role in addressing environmental externalities. The study also finds that in promoting energy efficiency, PUCs should pursue policies that are incentive-based, procompetitive, and sensitive to rate impacts. The study evaluates a number of traditional and nontraditional ratemaking mechanisms on the basis of cost minimization, energy efficiency, competitiveness, and other criteria. The mechanisms evaluated include direct recovery of DSM expenses, lost revenue adjustments for DSM options, revenue decoupling mechanisms, sharing of DSM cost savings, performance-based rate of return for DSM, provision of DSM as a separate service, deregulation of DSM service, price caps, and deregulation of the noncore gas market. The study concludes with general recommendations for regulatory approaches and ratemaking mechanisms that PUCs may wish to consider in advancing IRP objectives

  12. Local Management as a Proposal for the Solution of Urban Planning Common Problems in Latin America

    Directory of Open Access Journals (Sweden)

    Verónica Sánchez García

    2015-09-01

    Full Text Available The scene of the majority of Latin American cities is hopeless due the crisis faced by this part of the world. The decisive factor was globalization because it forced an economical restructuring and the implementation of new ways of production. Cities had to reorganize to deal with and adapt to this system through “global cities.” This way, it was possible to strengthen certain groups or population areas while ignoring others. This generated and emphasized poverty, which, at the same time, created social and environmental segregation, insecurity, mobility, lack of housing and utilities, overspend, waste of materials and human resources, as well as other institutional difficulties. These were a constant and limited the equitable access to social opportunities.For this reason, every urban planning and prediction system should take into account realistic circumstances that foster solidarity, participation, consensus, and sustainability as the central concept of the strategy to implement. This is known as “local management.” To manage a city implies working together with public, private, and social sectors in order to solve everyday problems efficiently and wisely. This way, it is possible to prevent and solve the difficulties faced by the community while searching for a common good and the recovery of its citizenship.

  13. A Local Action Plan (PAL to Combat Desertification in Apulia Region: Functional Integration of Existing Territorial Programs

    Directory of Open Access Journals (Sweden)

    Claudia Trotta

    2010-10-01

    Full Text Available In 2006-2007, the Italian National Committee to Combat Drought and Desertification promoted the execution of local action plans in some of the Italian regions. The aims of these plans were: to carry out specific actions at a local scale; to promote the integration of local policies; to involve the local communities in proposing strategies to be adopted; to harmonize the procedures among institutions in charge of adopting the policies. In this framework, ENEA carried out an evaluation of existing policies and programs to be considered in implementing a local action plan to combat desertification in the Apulia region. The application of the environmental and socio-economic measures of the regional Rural Development Plan 2007-2013 (PSR seemed to be an effective tool to positively influence human activities such as agriculture, breeding, and forestry, with the purpose of preserving or improving soil characteristics and overall environmental conditions, and eventually resulting in a reduction of desertification processes. Therefore, we proposed that these measures should be taken into account and effectively integrated into the Local Action Plan of the Apulia region. Additionally, we considered the four priority sectors identified by the National Action Plan (PAN to combat drought and desertification as the guiding principles to carry out our analysis. These sectors were: Soil Protection, Sustainable Water Management, Reduction of the Impact of Productive Activities, and Territorial Equilibrium. We also included Climate Change, in consideration of the alarming and urgent role it has assumed. The desertification-prone province of Foggia was selected as a pilot area in where to evaluate the influences that PSR measures can directly or indirectly have on desertification-related factors, and identify and implement specific actions. The Provincial Coordination Territorial Plan (PTCP of Foggia provided the basic land units for this analysis, the

  14. METHODOLOGICAL PROBLEMS OF LAND USE PLANNING LOCALLY IN TERMS OF NEW LAND RELATIONS AND DECENTRALIZATION OF POWER

    Directory of Open Access Journals (Sweden)

    N. Kapinos

    2017-05-01

    Full Text Available Summary Fundamental changes of land relations that have been established for the period of land reform in the independent Ukraine and the new socio-economic and environmental problems identified new character and content of the land. During the land reform in Ukraine to land management encountered new challenges that focus on the implementation of land policy and land relations fundamental change. Accordingly, to land management faces new challenges. Today for events to decentralize power facilities, new land - the territory united local communities should determine for whom the prospect of organizing the use and protection of land and other natural resources. However, the current land law the answer to this problem does not. Instead, normalization is an attempt to issues related to improving the quality of drafting documentation spatial planning (urban planning documents establish procedures for integrated development plans of local communities, the introduction of rules regulating local area to establish procedures for planning, construction and other use areas and about objects, improving public hearings to address public interests and relieve tension in the planning and construction of the territories. However, planning documentation does not solve the problems of perspective development of the organization use and protection of land and other natural resources. There is a need to distinguish between objects of regional urban planning and land management. This is because the urban planning regulations covering mainly two categories of land (settlements, industry, transport, communications and other purposes, not including agricultural land, which houses objects of capital construction. However, they make up for Ukraine just 4.2% of the total area. For the remaining seven categories of land (agricultural land, forest and water resources, conservation, recreation, recreational purposes land use planning and their protection should be based on

  15. Building the Capacity of States to Ensure Inclusion of Rural Communities in State and Local Primary Violence Prevention Planning

    Science.gov (United States)

    Cook-Craig, Patricia G.; Lane, Karen G.; Siebold, Wendi L.

    2010-01-01

    Rural, frontier, and geographically isolated communities face unique challenges associated with ensuring that they are equal partners in capacity-building and prevention planning processes at the state and local level despite barriers that can inhibit participation. By their nature, rural, frontier, and geographically isolated communities and…

  16. Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model.

    Science.gov (United States)

    Chen, Chien-Ho; Sheu, Ming-Thau; Wu, An-Bang; Lin, Keng-Ping; Ho, Hsiu-O

    2005-12-08

    In this study, topical minoxidil solutions supplemented with TPGS in cosolvent systems of various compositions consisting of water, alcohol, and polyethylene glycol 400 were designed to evaluate the efficacy of promoting hair growth after topical application and the safety in terms of the amount of minoxidil absorbed through the skin into the circulation using C57BL/6J mice as a model. The commercial product of 2% Regaine) was used as the positive control. The role, which sulfotransferase activity plays in hair growth with treatment using minoxidil, was determined as well. The results revealed that the addition of 0.5% TPGS was able to enhance the proliferation of hair, but an increase in the amount of TPGS to 2% led to deterioration in the enhancement of hair growth. At the higher added amount (2.0%) of TPGS, the promotion of hair growth was slightly reduced for both cosolvent formulations F1 (100% water) and F3 (100% PEG 400), whereas it was reduced to a greater extent for the cosolvent formulations F8-F10. In comparison, the influences of cosolvent compositions with TPGS amounts of 0.0 and 2.0% on the promotion of hair growth were similar. On the contrary, variability in the promotion of hair growth by different solvent formulations was minimal when the added amount of TPGS was 0.5%. In general, a relationship between hair growth and sulfotransferase activities after topical application of 2% Regaine and minoxidil formulations containing various amounts of TPGS was not demonstrated. Plasma concentrations of minoxidil with 2% Regaine were found to be greater than those of 2% minoxidil in those cosolvent formulations containing various amounts of TPGS, while showing insignificant differences among those 10 cosolvent formulations with a fixed amount of TPGS. A tendency for the plasma concentration of minoxidil to increase after the topical administration of minoxidil formulations containing the higher amount of TPGS (2%) was noted.

  17. Use of diffusion-weighted MRI to modify radiosurgery planning in brain metastases may reduce local recurrence.

    Science.gov (United States)

    Zakaria, Rasheed; Pomschar, Andreas; Jenkinson, Michael D; Tonn, Jörg-Christian; Belka, Claus; Ertl-Wagner, Birgit; Niyazi, Maximilian

    2017-02-01

    Stereotactic radiosurgery (SRS) is an effective and well tolerated treatment for selected brain metastases; however, local recurrence still occurs. We investigated the use of diffusion weighted MRI (DWI) as an adjunct for SRS treatment planning in brain metastases. Seventeen consecutive patients undergoing complete surgical resection of a solitary brain metastasis underwent image analysis retrospectively. SRS treatment plans were generated based on standard 3D post-contrast T1-weighted sequences at 1.5T and then separately using apparent diffusion coefficient (ADC) maps in a blinded fashion. Control scans immediately post operation confirmed complete tumour resection. Treatment plans were compared to one another and with volume of local recurrence at progression quantitatively and qualitatively by calculating the conformity index (CI), the overlapping volume as a proportion of the total combined volume, where 1 = identical plans and 0 = no conformation whatsoever. Gross tumour volumes (GTVs) using ADC and post-contrast T1-weighted sequences were quantitatively the same (related samples Wilcoxon signed rank test = -0.45, p = 0.653) but showed differing conformations (CI 0.53, p recurrence than the standard plan (median 3.53 cm 3 vs. 3.84 cm 3 , p = 0.002). ADC maps may be a useful tool in addition to the standard post-contrast T1-weighted sequence used for SRS planning.

  18. Local Cultural Heritage Sites and Spatial Planning for the Bantik Ethnic Community in Indonesia

    Directory of Open Access Journals (Sweden)

    Egam, P. P.

    2014-07-01

    Full Text Available The course of a city’s development has an effect on both spatial and social aspects, and this situation affects ethnic communities. As a result of recent urban developments, the cultural values of a community that are embedded in living arrangements have been disturbed, thus obscuring, or even hiding, the rich cultural heritage therein. The purpose of this paper is to analyze the spatial characteristics of local neighborhoods based on a wealth of cultural heritage objects. This research focuses on the physical cultural heritage of the Bantik settlement in Malalayang. The spatial characteristics of cultural heritage objects are analyzed, based on physical and other characteristics. The results indicate that, although the Bantik ethnic community in Malalayang, Indonesia, has physical cultural heritage sites, it is unable to effectively develop these as significant cultural spaces because of the physical separation of their locations, the declining meaning of these sites to the community, and the lack of support from indigenous organizations. Distance is not the only determinant of the optimization of cultural space. Planning for cultural spaces involves three zones: 1 a promotion zone, 2 a core zone, and 3 a buffer zone. The greatest potential for developing a cultural space is in the vicinity of Minanga Road and the Niopo Stone, with the physical object reinforcement of similar sites. To improve cultural space, it is not enough to only rely on the existence of a physical object, it is necessary to create a close relationship between the object and the community with the support of indigenous organizations.

  19. Recent advances in topical anesthesia

    Science.gov (United States)

    2016-01-01

    Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics. Recently, new products with modified ingredients and application methods have been introduced into the market. These products may be used for mild pain during periodontal treatment, such as scaling. Dentists should be aware that topical anesthetics, although rare, might induce allergic reactions or side effects as a result of an overdose. Topical anesthetics are useful aids during dental treatment, as they reduce dental phobia, especially in children, by mitigating discomfort and pain. PMID:28879311

  20. Planning Target Margin Calculations for Prostate Radiotherapy Based on Intrafraction and Interfraction Motion Using Four Localization Methods

    International Nuclear Information System (INIS)

    Beltran, Chris; Herman, Michael G.; Davis, Brian J.

    2008-01-01

    Purpose: To determine planning target volume (PTV) margins for prostate radiotherapy based on the internal margin (IM) (intrafractional motion) and the setup margin (SM) (interfractional motion) for four daily localization methods: skin marks (tattoo), pelvic bony anatomy (bone), intraprostatic gold seeds using a 5-mm action threshold, and using no threshold. Methods and Materials: Forty prostate cancer patients were treated with external radiotherapy according to an online localization protocol using four intraprostatic gold seeds and electronic portal images (EPIs). Daily localization and treatment EPIs were obtained. These data allowed inter- and intrafractional analysis of prostate motion. The SM for the four daily localization methods and the IM were determined. Results: A total of 1532 fractions were analyzed. Tattoo localization requires a SM of 6.8 mm left-right (LR), 7.2 mm inferior-superior (IS), and 9.8 mm anterior-posterior (AP). Bone localization requires 3.1, 8.9, and 10.7 mm, respectively. The 5-mm threshold localization requires 4.0, 3.9, and 3.7 mm. No threshold localization requires 3.4, 3.2, and 3.2 mm. The intrafractional prostate motion requires an IM of 2.4 mm LR, 3.4 mm IS and AP. The PTV margin using the 5-mm threshold, including interobserver uncertainty, IM, and SM, is 4.8 mm LR, 5.4 mm IS, and 5.2 mm AP. Conclusions: Localization based on EPI with implanted gold seeds allows a large PTV margin reduction when compared with tattoo localization. Except for the LR direction, bony anatomy localization does not decrease the margins compared with tattoo localization. Intrafractional prostate motion is a limiting factor on margin reduction

  1. Coign of Vantage and Action: Considering California's Local Accountability and School Finance Plans for English Learners

    Science.gov (United States)

    Vasquez Heilig, Julian; Romero, Lisa S.; Hopkins, Megan

    2017-01-01

    Local control has been a bedrock principle of public schooling in America since its inception. In 2013, the California Legislature codified a new local accountability approach for school finance. An important component of the new California Local Control Funding Formula (LCFF) approach is a focus on English learners (ELs). The law mandates that…

  2. The critical spot eraser—a method to interactively control the correction of local hot and cold spots in IMRT planning

    International Nuclear Information System (INIS)

    Süss, Philipp; Bortz, Michael; Küfer, Karl-Heinz; Thieke, Christian

    2013-01-01

    Common problems in inverse radiotherapy planning are localized dose insufficiencies like hot spots in organs at risk or cold spots inside targets. These are hard to correct since the optimization is based on global evaluations like maximum/minimum doses, equivalent uniform doses or dose–volume constraints for whole structures. In this work, we present a new approach to locally correct the dose of any given treatment plan. Once a treatment plan has been found that is acceptable in general but requires local corrections, these areas are marked by the planner. Then the system generates new plans that fulfil the local dose goals. Consequently, it is possible to interactively explore all plans between the locally corrected plans and the original treatment plan, allowing one to exactly adjust the degree of local correction and how the plan changes overall. Both the amount (in Gy) and the size of the local dose change can be navigated. The method is introduced formally as a new mathematical optimization setting, and is evaluated using a clinical example of a meningioma at the base of the skull. It was possible to eliminate a hot spot outside the target volume while controlling the dose changes to all other parts of the treatment plan. The proposed method has the potential to become the final standard step of inverse treatment planning. For more information on this article, see medicalphysicsweb.org (paper)

  3. Local Climate Zones Classification to Urban Planning in the Mega City of São Paulo - SP, Brazil

    Science.gov (United States)

    Gonçalves Santos, Rafael; Saraiva Lopes, António Manuel; Prata-Shimomura, Alessandra

    2017-04-01

    Local Climate Zones Classification to Urban Planning in the Mega city of São Paulo - SP, Brazil Tropical megacities have presented a strong trend in growing urban. Urban management in megacities has as one of the biggest challenges is the lack of integration of urban climate and urban planning to promote ecologically smart cities. Local Climatic Zones (LCZs) are considered as important and recognized tool for urban climate management. Classes are local in scale, climatic in nature, and zonal in representation. They can be understood as regions of uniform surface cover, structure, material and human activity that have to a unique climate response. As an initial tool to promote urban climate planning, LCZs represent a simple composition of different land coverages (buildings, vegetation, soils, rock, roads and water). LCZs are divided in 17 classes, they are based on surface cover (built fraction, soil moisture, albedo), surface structure (sky view factor, roughness height) and cultural activity (anthropogenic heat flux). The aim of this study is the application of the LCZs classification system in the megacity of São Paulo, Brazil. Located at a latitude of 23° 21' and longitude 46° 44' near to the Tropic of Capricorn, presenting humid subtropical climate (Cfa) with diversified topographies. The megacity of São Paulo currently concentrates 11.890.000 inhabitants is characterized by large urban conglomerates with impermeable surfaces and high verticalization, having as result high urban heat island intensity. The result indicates predominance in urban zones of Compact low-rise, Compact Mid-rise, Compact High-rise and Open Low-rise. Non-urban regions are mainly covered by dense vegetation and water. The LCZs classification system promotes significant advantages for climate sensitive urban planning in the megacity of São Paulo. They offers new perspectives to the management of temperature and urban ventilation and allows the formulation of urban planning

  4. The relationship between the bladder volume and optimal treatment planning in definitive radiotherapy for localized prostate cancer

    International Nuclear Information System (INIS)

    Nakamura, Naoki; Sekiguchi, Kenji; Akahane, Keiko; Shikama, Naoto; Takahashi, Osamu; Hama, Yukihiro; Nakagawa, Keiichi

    2012-01-01

    Background and purpose: There is no current consensus regarding the optimal bladder volumes in definitive radiotherapy for localized prostate cancer. The aim of this study was to clarify the relationship between the bladder volume and optimal treatment planning in radiotherapy for localized prostate cancer. Material and methods: Two hundred and forty-three patients underwent definitive radiotherapy with helical tomotherapy for intermediate- and high-risk localized prostate cancer. The prescribed dose defined as 95 % of the planning target volume (PTV) receiving 100 % of the prescription dose was 76 Gy in 38 fractions. The clinical target volume (CTV) was defined as the prostate with a 5-mm margin and 2 cm of the proximal seminal vesicle. The PTV was defined as the CTV with a 5-mm margin. Treatment plans were optimized to satisfy the dose constraints defined by in-house protocols for PTV and organs at risk (rectum wall, bladder wall, sigmoid colon and small intestine). If all dose constraints were satisfied, the plan was defined as an optimal plan (OP). Results: An OP was achieved with 203 patients (84%). Mean bladder volume (± 1 SD) was 266 ml (± 130 ml) among those with an OP and 214 ml (±130 ml) among those without an OP (p = 0.02). Logistic regression analysis also showed that bladder volumes below 150 ml decreased the possibility of achieving an OP. However, the percentage of patients with an OP showed a plateau effect at bladder volumes above 150 ml. Conclusions. Bladder volume is a significant factor affecting OP rates. However, our results suggest that bladder volumes exceeding 150 ml may not help meet planning dose constraints

  5. Topical immunomodulators in dermatology

    Directory of Open Access Journals (Sweden)

    Khandpur Sujay

    2004-04-01

    Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

  6. Quality Assurance Project Plan for the HWMA/RCRA Closure Certification of the TRA-731 Caustic and Acid Storage Tank System - 1997 Notice of Violation Consent Order; TOPICAL

    International Nuclear Information System (INIS)

    Evans, S.K.

    2002-01-01

    This Quality Assurance Project Plan for the HWMA/RCRA Closure Certification of the TRA- 731 Caustic and Acid Storage Tank System is one of two documents that comprise the Sampling and Analysis Plan for the HWMA/RCRA closure certification of the TRA-731 caustic and acid storage tank system at the Idaho National Engineering and Environmental Laboratory. This plan, which provides information about the project description, project organization, and quality assurance and quality control procedures, is to be used in conjunction with the Field Sampling Plan for the HWMA/RCRA Closure Certification of the TRA-731 Caustic and Acid Storage Tank System. This Quality Assurance Project Plan specifies the procedures for obtaining the data of known quality required by the closure activities for the TRA-731 caustic and acid storage tank system

  7. A Capital-Financing Plan for School Systems and Local Government

    Science.gov (United States)

    Hodge, Penny

    2012-01-01

    School business officials are best equipped to lead in funding operating and capital needs because they understand the need for a methodical means of funding ongoing costs over time and the benefits of planning for future financial needs rather than letting emergencies dictate spending priorities. A capital-financing plan makes it possible to…

  8. An Integrative Approach to Value-Added Planning: From Community Needs to Local Authority Revenue

    NARCIS (Netherlands)

    Cilliers, E.J.; Timmermans, W.

    2015-01-01

    The concept of value-added planning (as part of the Valuing Attractive Landscapes in the Urban Economy, INTERREG IVB North West Europe Project) is introduced in this paper to facilitate integrative planning, focusing on the benefits that use and non-use green spaces can provide to an urban area. The

  9. Exploring the Factors of an Enterprise Resource Planning System in a Local Government Organization

    Science.gov (United States)

    Shaw, Bryan T.

    2012-01-01

    The enterprise resource planning (ERP) system industry accounts for $8.8 billion annually. Enterprise resource planning systems are not performing as expected due to implementation barriers, changes in job responsibilities, and access to information; 50% of all information technology failures are due to the implementation of ERP systems. Guided by…

  10. Exploration on Planning Methods for Rural Communities in the Local Economic and Institutional Contexts

    Institute of Scientific and Technical Information of China (English)

    Ying; WANG; Xin; PAN; Zhilun; XIAO; Xiangwei; CHENG; Caige; LI

    2014-01-01

    This paper reviews the wave of rural community construction, compares the urban and rural areas on the aspects of land property right, financing channels, construction management procedures, and the user-builder difference, and examines the unique characteristics of rural communities. On the basis of that, it proposes some planning methods for the rural community planning and construction, such as encouraging public participation, conducting public facility-oriented planning, and providing house-design menu, and further puts forward some supporting measures and policies.

  11. Local pursuit strategy-inspired cooperative trajectory planning algorithm for a class of nonlinear constrained dynamical systems

    Science.gov (United States)

    Xu, Yunjun; Remeikas, Charles; Pham, Khanh

    2014-03-01

    Cooperative trajectory planning is crucial for networked vehicles to respond rapidly in cluttered environments and has a significant impact on many applications such as air traffic or border security monitoring and assessment. One of the challenges in cooperative planning is to find a computationally efficient algorithm that can accommodate both the complexity of the environment and real hardware and configuration constraints of vehicles in the formation. Inspired by a local pursuit strategy observed in foraging ants, feasible and optimal trajectory planning algorithms are proposed in this paper for a class of nonlinear constrained cooperative vehicles in environments with densely populated obstacles. In an iterative hierarchical approach, the local behaviours, such as the formation stability, obstacle avoidance, and individual vehicle's constraints, are considered in each vehicle's (i.e. follower's) decentralised optimisation. The cooperative-level behaviours, such as the inter-vehicle collision avoidance, are considered in the virtual leader's centralised optimisation. Early termination conditions are derived to reduce the computational cost by not wasting time in the local-level optimisation if the virtual leader trajectory does not satisfy those conditions. The expected advantages of the proposed algorithms are (1) the formation can be globally asymptotically maintained in a decentralised manner; (2) each vehicle decides its local trajectory using only the virtual leader and its own information; (3) the formation convergence speed is controlled by one single parameter, which makes it attractive for many practical applications; (4) nonlinear dynamics and many realistic constraints, such as the speed limitation and obstacle avoidance, can be easily considered; (5) inter-vehicle collision avoidance can be guaranteed in both the formation transient stage and the formation steady stage; and (6) the computational cost in finding both the feasible and optimal

  12. PLACE-BASED GREEN BUILDING: INTEGRATING LOCAL ENVIRONMENTAL AND PLANNING ANALYSIS INTO GREEN BUILDING GUIDELINES

    Science.gov (United States)

    This project will develop a model for place-based green building guidelines based on an analysis of local environmental, social, and land use conditions. The ultimate goal of this project is to develop a methodology and model for placing green buildings within their local cont...

  13. Effect of Radiotherapy Planning Complexity on Survival of Elderly Patients With Unresected Localized Lung Cancer

    International Nuclear Information System (INIS)

    Park, Chang H.; Bonomi, Marcelo; Cesaretti, Jamie; Neugut, Alfred I.; Wisnivesky, Juan P.

    2011-01-01

    Purpose: To evaluate whether complex radiotherapy (RT) planning was associated with improved outcomes in a cohort of elderly patients with unresected Stage I-II non-small-cell lung cancer (NSCLC). Methods and Materials: Using the Surveillance, Epidemiology, and End Results registry linked to Medicare claims, we identified 1998 patients aged >65 years with histologically confirmed, unresected stage I-II NSCLC. Patients were classified into an intermediate or complex RT planning group using Medicare physician codes. To address potential selection bias, we used propensity score modeling. Survival of patients who received intermediate and complex simulation was compared using Cox regression models adjusting for propensity scores and in a stratified and matched analysis according to propensity scores. Results: Overall, 25% of patients received complex RT planning. Complex RT planning was associated with better overall (hazard ratio 0.84; 95% confidence interval, 0.75-0.95) and lung cancer-specific (hazard ratio 0.81; 95% confidence interval, 0.71-0.93) survival after controlling for propensity scores. Similarly, stratified and matched analyses showed better overall and lung cancer-specific survival of patients treated with complex RT planning. Conclusions: The use of complex RT planning is associated with improved survival among elderly patients with unresected Stage I-II NSCLC. These findings should be validated in prospective randomized controlled trials.

  14. High-precision piezo-ejection ocular microdosing: Phase II study on local and systemic effects of topical phenylephrine.

    Science.gov (United States)

    Ianchulev, Tsontcho; Weinreb, Robert; Tsai, James C; Lin, Shan; Pasquale, Louis R

    2018-01-01

    Conventional eyedropper-delivered volumes (25-50 µl) exceed the eye's usual tear-film volume (7 µl) and precorneal reservoir capacity, risking overflow and ocular/systemic complications. Piezoelectric high-precision microdosing may circumvent these limitations. Results & methodology: In this masked, nonrandomized, cross-over study, subjects (n = 12) underwent pupil dilation with topical phenylephrine (PE) administered by 32-µl eyedropper (2.5% or 10% formulation) and 8-µl electronic microdosing (10% formulation). Microdosing with PE-10% achieved comparable peak dilation as 10% eyedropper-delivery and superior dilation to 2.5% eyedropper-delivery (p = 0.009) at 75 min. Microdosing significantly reduced 20-min plasma PE levels versus PE10% eyedropper; neither treatment altered heart rate/blood pressure. Eye irritation occurred significantly less frequently with microdosing than PE10% eyedrops. Piezo-ejection PE microdosing achieves comparable biological effect as eyedropper dosing; reduced systemic absorption may decrease risk of systemic side effects.

  15. Local governments and climate change: sustainable energy planning and implementation in small and medium sized communities

    National Research Council Canada - National Science Library

    Van Staden, Maryke; Musco, Francesco

    2010-01-01

    ...) motivations and actions. The most effective responses are those with a holistic, integrated and lon-term approach, addressing both climate change mitigation and adaptation, based on citizen and other local stakeholder involvement...

  16. Local governments and climate change: sustainable energy planning and implementation in small and medium sized communities

    National Research Council Canada - National Science Library

    Van Staden, Maryke; Musco, Francesco

    2010-01-01

    The focus of 'Local governments and climate change' is on how small and medium-sized communities in Europe are effectively responding to climate change, with a particular focus on different approaches...

  17. Local Government Planning Tool to Calculate Institutional and Engineering Control Costs for Brownfield Properties

    Science.gov (United States)

    This cost calculator is designed as a guide for municipal or local governments to assist in calculating their expected costs of implementing and conducting long-term stewardship of institutional controls and engineering controls at brownfield properties.

  18. The Environmental Advisory Service (EASe): a decision support system for comprehensive screening of local land-use development proposals and comparative evaluation of proposed land-use plans

    OpenAIRE

    K P White; A P Sage; F A Rodammer; C T Peters

    1985-01-01

    The Environmental Advisory Service (EASe) is a decision support system which can provide assistance to local planning agencies in selecting land-development alternatives or in formulating land-use plans. EASe offers a comprehensive and consistent procedure for rating either a development proposal or a proposed plan. This procedure is based upon qualitative assessments of the impact of developments or plans on the natural environment, zoning and land use. public and private services, transport...

  19. Local government involvement in long term resource planning for community energy systems. Demand side management

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    A program was developed to coordinate governmental, research, utility, and business energy savings efforts, and to evaluate future potential actions, based on actual field data obtained during the implementation of Phase I of the State Resource Plan. This has lead to the establishment of a state conservation and energy efficiency fund for the purpose of establishing a DSM Program. By taking a state wide perspective on resource planning, additional savings, including environmental benefits, can be achieved through further conservation and demand management. This effort has already blossomed into a state directive for DSM programs for the natural gas industry.

  20. Local government involvement in long term resource planning for community energy systems

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    A program was developed to coordinate governmental, research, utility, and business energy savings efforts, and to evaluate future potential actions, based on actual field data obtained during the implementation of Phase I of the State Resource Plan. This has lead to the establishment of a state conservation and energy efficiency fund for the purpose of establishing a DSM Program. By taking a state wide perspective on resource planning, additional savings, including environmental benefits, can be achieved through further conservation and demand management. This effort has already blossomed into a state directive for DSM programs for the natural gas industry.

  1. Site systems engineering fiscal year 1999 multi-year work plan (MYWP) update for WBS 1.8.2.2; TOPICAL

    International Nuclear Information System (INIS)

    GRYGIEL, M.L.

    1998-01-01

    Manage the Site Systems Engineering process to provide a traceable integrated requirements-driven, and technically defensible baseline. Through the Site Integration Group(SIG), Systems Engineering ensures integration of technical activities across all site projects. Systems Engineering's primary interfaces are with the RL Project Managers, the Project Direction Office and with the Project Major Subcontractors, as well as with the Site Planning organization. Systems Implementation: (1) Develops, maintains, and controls the site integrated technical baseline, ensures the Systems Engineering interfaces between projects are documented, and maintain the Site Environmental Management Specification. (2) Develops and uses dynamic simulation models for verification of the baseline and analysis of alternatives. (3) Performs and documents fictional and requirements analyses. (4) Works with projects, technology management, and the SIG to identify and resolve technical issues. (5) Supports technical baseline information for the planning and budgeting of the Accelerated Cleanup Plan, Multi-Year Work Plans, Project Baseline Summaries as well as performance measure reporting. (6) Works with projects to ensure the quality of data in the technical baseline. (7) Develops, maintains and implements the site configuration management system

  2. Evaluation of geothermal energy in Arizona. Arizona geothermal planning/commercialization team. Quarterly topical progress report, July 1-September 30, 1980

    Energy Technology Data Exchange (ETDEWEB)

    White, D.H.; Mancini, F.; Goldstone, L.A.; Malysa, L.

    1980-01-01

    Progress is reviewed on the following: area development plans, evaluation of geothermal applications, continued evaluation of geothermal resources, engineering and economic analyses, technical assistance in the state of Arizona, the impact of various growth patterns upon geothermal energy development, and the outreach program. (MHR)

  3. TERRITORIAL LAND-USE PLANNING IN THE CONTEXT OF FORMATION THE FINANCIAL STABILITY OF THE UNITED LOCAL COMMUNITIES

    Directory of Open Access Journals (Sweden)

    Tretiak A.

    2017-02-01

    Full Text Available Territorial planning now is one of the essential attributes of management activities developed countries. The modern system of planning land- use in Ukraine now is not formed and balanced and does not provide positive results in achieving its high economic efficiency and environmental safety. Territorial planning of land use wasn’t needed by system of state and municipal administration because there are problems in the territorial land management which are related with insufficient compliance current needs of sustainable development. If planning of development in the cities (towns is developed and makes of base planning documentation (general plans then the area of land ownership and land use outside towns isn’t covered completely creation of land documents. In Ukraine in most scientific research view separate aspects of influence territorial use of planning the spatial organization of economic activities of local communities. For the new community situation in use land and natural resources became difficult, first of all through: -underestimation of the complexity and specificity of land reform during land and economic reforms in Ukraine; - local community hasn’t full information about rights to land and other natural resources, their potential use and protection of the state; - incompetence of system solving problems of land reform in the local councils, for example : remove communities from order of land in their territories, lands of state and municipal property aren’t separated, land reform and land tenure systems, especially in agriculture are incomplete; - unsatisfactory legal and information support and protection of property rights of villagers to land and other natural resources; - ignoring the problems of putting into economic turnover of land as a capital resource and integrated approach to village territories in development the transformation of land relations, absence of a balanced state land politics of planning of land

  4. 25 CFR 47.9 - What are the minimum requirements for the local educational financial plan?

    Science.gov (United States)

    2010-04-01

    ... EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.9 What are the minimum..., including each program funded through the Indian School Equalization Program; (2) A budget showing the costs...) Certification by the chairman of the school board that the plan has been ratified in an action of record by the...

  5. Cultural Planning: New Inspiration for Local Governments in the Czech Context

    Czech Academy of Sciences Publication Activity Database

    Vojtíšková, Kateřina; Poláková, Markéta; Patočková, Věra

    2016-01-01

    Roč. 46, č. 1 (2016), s. 22-33 ISSN 1063-2921. E-ISSN 1930-7799 R&D Projects: GA MK DF11P01OVV032 Keywords : Action research * cultural planning * Czech Republic Subject RIV: AE - Management ; Administration http://www.tandfonline.com/doi/abs/10.1080/10632921.2015.1121183?journalCode=vjam20

  6. Port Cities and Urban Waterfronts : How Localized Planning Ignores Water as Connector

    NARCIS (Netherlands)

    Hein, C.M.

    2016-01-01

    People have redesigned coastlines, creating ports, shaping waterfronts, and building cities to connect water and land. Specialists from many disciplines have explored the function and design of the water–land transition over many centuries. Among them is planning, a discipline that engages both with

  7. Tracking Eye Movements to Localize Stroop Interference in Naming: Word Planning Versus Articulatory Buffering

    NARCIS (Netherlands)

    Roelofs, A.P.A.

    2014-01-01

    Investigators have found no agreement on the functional locus of Stroop interference in vocal naming. Whereas it has long been assumed that the interference arises during spoken word planning, more recently some investigators have revived an account from the 1960s and 1970s holding that the

  8. Increased risk of biochemical and local failure in patients with distended rectum on the planning CT for prostate cancer radiotherapy

    International Nuclear Information System (INIS)

    Crevoisier, Renaud de; Tucker, Susan L.; Dong Lei; Mohan, Radhe; Cheung, Rex; Cox, James D.; Kuban, Deborah A.

    2005-01-01

    Purpose: To retrospectively test the hypothesis that rectal distension on the planning computed tomography (CT) scan is associated with an increased risk of biochemical and local failure among patients irradiated for prostate carcinoma when a daily repositioning technique based on direct prostate-organ localization is not used. Methods and Materials: This study included 127 patients who received definitive three-dimensional conformal radiotherapy for prostate cancer to a total dose of 78 Gy at University of Texas M.D. Anderson Cancer Center. Rectal distension was assessed by calculation of the average cross-sectional rectal area (CSA; defined as the rectal volume divided by length) and measuring three rectal diameters on the planning CT. The impact of rectal distension on biochemical control, 2-year prostate biopsy results, and incidence of Grade 2 or greater late rectal bleeding was assessed. Results: The incidence of biochemical failure was significantly higher among patients with distended rectums (CSA >11.2 cm 2 ) on the planning CT scan (p 0.0009, log-rank test). Multivariate analysis indicates that rectal distension and high-risk disease are independent risk factors for biochemical failure, with hazard ratios of 3.89 (95% C.I. 1.58 to 9.56, p = 0.003) and 2.45 (95% C.I. 1.18 to 5.08, p = 0.016), respectively. The probability of residual tumor without evidence of radiation treatment (as scored by the pathologist) increased significantly with rectal distension (p = 0.010, logistic analysis), and a lower incidence of Grade 2 or greater late rectal bleeding within 2 years was simultaneously observed with higher CSA values (p = 0.031, logistic analysis). Conclusions: We found strong evidence that rectal distension on the treatment-planning CT scan decreased the probability of biochemical control, local control, and rectal toxicity in patients who were treated without daily image-guided prostate localization, presumably because of geographic misses. Therefore, an

  9. Tumor and normal structures volume localization and quantitation in 3D radiotherapy treatment planning

    International Nuclear Information System (INIS)

    Anselmi, R.; Andreucci, L.

    1995-01-01

    Improvements in imaging technology have significantly enhanced the ability of the radiation oncologist to stage and to evaluate the response of tumor during and after treatment. Over the last few year, in fact, computed tomography (CT), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), single photon emission computed tomography (SPECT) imaging radiolabelled monoclonal tumor antibodies have allowed tumor definition and evaluation. Concerning the above mentioned techniques accurate methods for the integration of morphological (CT, MRI) and functional (PET, SPECT, MRS) information can be very useful for volumes definition. In fact three-dimensional treatment planning depends heavily on volume displays and calculation based on volumes to convey information to the radiation oncologist, physicist and dosimetrist. The accuracy and reproducibility of the methods for creating these volumes are fundamental limitations of current treatment planning systems. Slice by slice manual contouring, which is extremely labor-intensive, and automatic edge detection, which has a high failure rate and requires human intervention are representative of the current standard of practice. The aim of our work is both to develop methods of image data integration and automatic segmentation, and to make the treatment planning system able to combine these multiple information in unified data set in order to get a better tumor volume definition and dose distribution calculation. Then the possibility of using morphological and functional images and other information coming from MR spectroscopy and electronic or confocal microscopy can allow the development into the treatment planning system of biological calculation models for evaluating tumor and normal tissue control probabilities (TCP, NTCP). The definitive use of these models into the 3-D treatment plannings will offer a considerable improvement in the biological efficacy of radiotherapy and it will constitute the object

  10. Local Action Groups and Rural Sustainable Development. A spatial multiple criteria approach for efficient territorial planning

    DEFF Research Database (Denmark)

    Palmisano, Giovanni Ottomano; Govindan, M.E., PhD.,, Kannan; Boggia, Antonio

    2016-01-01

    Local Action Groups in order to promote the objectives of Rural Sustainable Development within rural municipalities. Each Local Action Group applies the Strengths, Weaknesses, Opportunities and Threats analysis in order to identify for its own rural municipalities the strategic elements to which...... and a Weakness factors and decision alternatives, as well as impossibility of ranking the decision alternatives. Thus, this research aims to overcome the drawbacks of the Strengths, Weaknesses, Opportunities and Threats analysis and to support Local Action Group partnerships in the sustainability evaluation...... of their rural municipalities, and therefore to aid the identification of a common Rural Sustainable Development strategy to allocate the European Agricultural Fund for Rural Development budget. This decision problem was tackled by applying a Multiple Criteria Spatial Decision Support System that integrates...

  11. ANALYSIS OF THE POSSIBILITY OF USING HYDROLOGICAL MODELS IN STRATEGIC ENVIRONMENTAL ASSESSMENT OF LOCAL SPATIAL DEVELOPMENT PLANS

    Directory of Open Access Journals (Sweden)

    Mariusz Sojka

    2014-10-01

    Full Text Available The paper presents the possibility of application of the hydrological model HEC-HMS in the development of a strategic environmental assessment of local spatial development plans on surface water. The practical possibility of using simulation models of catchment response to high intensity precipitation is shown on the example of the Różany Potok watercourse catchment which is subject to rapid urbanization process. The area of Różany Potok catchment is 8.1 km2 and a stream length is 5.57 km. In the years 1992–2012 there was a significant increase in impervious areas in the catchment of about 5.2 to 16%. In addition, new local spatial development plans are prepared within the catchment area. The implementation of their records may contribute to the increase in the proportion of impervious areas to over 20%. The increase in the share of impervious areas in the catchment area and traditional approach of precipitation water management can lead to doubling flood flows and increase the risk of local flooding.

  12. Risk-informed local action planning against flooding: lessons learnt and way forward for a case study in Spain

    Directory of Open Access Journals (Sweden)

    Castillo-Rodríguez J.T.

    2016-01-01

    Full Text Available After 29 years of the largest flood event in modern times (with the highest recorded rainfall rate at the Iberian Peninsula with 817 mm in 24 hours, the municipality of Oliva faces the challenge of mitigating flood risk through the development and implementation of a local action plan, in line with other existent and ongoing structural measures for flood risk reduction. Located 65 km from Valencia, on the South-Eastern coast of Spain, Oliva is affected by pluvial, river and coastal flooding and it is characterized by a complex and wide-ranging geography and high seasonal variation in population. A quantitative flood risk analysis has been performed to support the definition of flood risk management strategies. This paper shows how hazard, exposure and vulnerability analyses provide valuable information for the development of a local action plan against flooding, for example by identifying areas with highest societal and economic risk levels. It is concluded that flood risk management actions, such as flood warning and monitoring or evacuation, should not be applied homogenously at local scale, but instead actions should be adapted based on spatial clustering. Implications about the impact of education and training on flood risk reduction are also addressed and discusse

  13. The Role of Local Community in the Marketing Planning for Sustainable Tourism National Park Skadar Lake (Montenegro

    Directory of Open Access Journals (Sweden)

    Darko Lacmanović

    2014-07-01

    Full Text Available The relationship between local community and tourism sector is an important issue in the marketing management of tourist destinations in theoretical and practical terms. It is especially important to consider specific issues relating to sustainable tourism marketing process and the participation of local people in the process. The subject of this work is to determine the existence of significant differences in the local community attachment and involment that may affect the marketing plan in offering different types of sustainable tourism in the National Park “Skadar Lake”.The research was conducted using a survey on a sample of 51 households in the stated area, using few statistical method for processing data (The T-test for independent samples; ANOVA.Examined: the perceived importance of the supply of sustainable forms of tourism; attitude towards tourists / visitors and the perception level of tourism marketing trends.Testing the validity of the hypotheses noted the following. Rejection of Hypothesis 1 clearly states that men and women do not have clear differences of opinions regarding the development of sustainable tourism offers. Partially confirmed Hypothesis 2 showed a more significant difference in the positive attitudes of the middle-aged group, which indicates the need for careful marketing communication in relation to other age groups. Confirming the Hypothesis 3 has highlighted the clearer perception of local residents who are employed in the tourism sector about the advantages and disadvantages of tourism development. The Hypothesis 4 regarding significant monitoring of the developments in the tourism market of highly educated residents and resident-employees in the tourism sector, public services, culture and education in relation to other comparable groups has been confirmed. The rejection of the Hypothesis 5 shows that the place of residence does not significantly affect the views of local residents about the development of

  14. Local Environmental Action Plan of municipalities of Centar, Zrnovci, Veles and Gevgelija (Republic of Macedonia)

    International Nuclear Information System (INIS)

    1998-08-01

    The Regional Environmental Center for Central and Eastern Europe (REC) is an independent, international organization established in 1990 by Hungary, the United States and the Commission of the European Communities. Twelve countries have since joined these founding sponsors. All of the REC's programs are unified in their resolve to promote regional cooperation among diverse interest groups in Central and Eastern Europe, to build the capacity of stake holders, to solve environmental problems, and to promote the development of a civil society. The book provides description of environmental action plans (LEAPs) of four different municipalities in Macedonia, identified by REC in collaboration with the Ministry for Urban Planning, Construction and Environmental of Republic of Macedonia. These municipalities are: 1) Centar (Skopje), which occupies central part of the capital of Macedonia, as a typical urban area; 2) Veles as a typical industrial area; 3) Zrnovci as a typical agricultural area; 4) Gevgelija as a transboundary and transit area

  15. Role of RENAL nephrometry scoring system in planning surgical intervention in patients with localized renal mas

    OpenAIRE

    Mohamed Samir Shaaban; Tamer Mohammed Abou Youssif; Ahmed Mostafa; Hossam Eldin Hegazy; Mohammed Adel Atta

    2015-01-01

    Purpose: The study was designed to validate the value of preoperative planning using RENAL nephrometry scoring system in patients having organ confined renal tumors and undergoing surgical intervention and to assess its correlation with the surgical technique. Patient and methods: Forty patients with organ-confined renal masses underwent RENAL nephrometry scoring which was correlated with the surgical technique either radical or nephron-sparing surgery. Result: RENAL nephrometry scoring...

  16. Integration of local participatory and regional planning for resources management using remote sensing and GIS

    NARCIS (Netherlands)

    Sedogo, L.G.

    2002-01-01

    With the introduction of participatory approaches in development programs, it has become essential for planners to build and implement land use strategies based on the objectives, perceptions and knowledge of local people. Despite the richness of participatory rural appraisal (PRA)

  17. ANALYSIS OF THE POSSIBILITY OF USING HYDROLOGICAL MODELS IN STRATEGIC ENVIRONMENTAL ASSESSMENT OF LOCAL SPATIAL DEVELOPMENT PLANS

    OpenAIRE

    Mariusz Sojka; Sadżide Murat-Błażejewska; Rafał Wróżyński

    2014-01-01

    The paper presents the possibility of application of the hydrological model HEC-HMS in the development of a strategic environmental assessment of local spatial development plans on surface water. The practical possibility of using simulation models of catchment response to high intensity precipitation is shown on the example of the Różany Potok watercourse catchment which is subject to rapid urbanization process. The area of Różany Potok catchment is 8.1 km2 and a stream length is 5.57 km. In...

  18. Site Development, Operations, and Closure Plan Topical Report 5 An Assessment of Geologic Carbon Sequestration Options in the Illinois Basin. Phase III

    Energy Technology Data Exchange (ETDEWEB)

    Finley, Robert [Univ. of Illinois, Champaign, IL (United States); Payne, William [Schlumberger Carbon Services, Houston, TX (United States); Kirksey, Jim [Univ. of Illinois, Champaign, IL (United States)

    2015-06-01

    The Midwest Geological Sequestration Consortium (MGSC) has partnered with Archer Daniels Midland Company (ADM) and Schlumberger Carbon Services to conduct a large-volume, saline reservoir storage project at ADM’s agricultural products processing complex in Decatur, Illinois. The Development Phase project, named the Illinois Basin Decatur Project (IBDP) involves the injection of 1 million tonnes of carbon dioxide (CO2) into a deep saline formation of the Illinois Basin over a three-year period. This report focuses on objectives, execution, and lessons learned/unanticipated results from the site development (relating specifically to surface equipment), operations, and the site closure plan.

  19. Radiotherapy beyond cancer: Target localization in real-time MRI and treatment planning for cardiac radiosurgery

    International Nuclear Information System (INIS)

    Ipsen, S.; Blanck, O.; Rades, D.; Oborn, B.; Bode, F.; Liney, G.; Hunold, P.; Schweikard, A.; Keall, P. J.

    2014-01-01

    Purpose: Atrial fibrillation (AFib) is the most common cardiac arrhythmia that affects millions of patients world-wide. AFib is usually treated with minimally invasive, time consuming catheter ablation techniques. While recently noninvasive radiosurgery to the pulmonary vein antrum (PVA) in the left atrium has been proposed for AFib treatment, precise target location during treatment is challenging due to complex respiratory and cardiac motion. A MRI linear accelerator (MRI-Linac) could solve the problems of motion tracking and compensation using real-time image guidance. In this study, the authors quantified target motion ranges on cardiac magnetic resonance imaging (MRI) and analyzed the dosimetric benefits of margin reduction assuming real-time motion compensation was applied. Methods: For the imaging study, six human subjects underwent real-time cardiac MRI under free breathing. The target motion was analyzed retrospectively using a template matching algorithm. The planning study was conducted on a CT of an AFib patient with a centrally located esophagus undergoing catheter ablation, representing an ideal case for cardiac radiosurgery. The target definition was similar to the ablation lesions at the PVA created during catheter treatment. Safety margins of 0 mm (perfect tracking) to 8 mm (untracked respiratory motion) were added to the target, defining the planning target volume (PTV). For each margin, a 30 Gy single fraction IMRT plan was generated. Additionally, the influence of 1 and 3 T magnetic fields on the treatment beam delivery was simulated using Monte Carlo calculations to determine the dosimetric impact of MRI guidance for two different Linac positions. Results: Real-time cardiac MRI showed mean respiratory target motion of 10.2 mm (superior–inferior), 2.4 mm (anterior–posterior), and 2 mm (left–right). The planning study showed that increasing safety margins to encompass untracked respiratory motion leads to overlapping structures even in the

  20. Radiotherapy beyond cancer: Target localization in real-time MRI and treatment planning for cardiac radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Ipsen, S. [Radiation Physics Laboratory, Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia and Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck 23562 (Germany); Blanck, O.; Rades, D. [Department of Radiation Oncology, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck 23562 (Germany); Oborn, B. [Illawarra Cancer Care Centre (ICCC), Wollongong, New South Wales 2500, Australia and Centre for Medical Radiation Physics (CMRP), University of Wollongong, Wollongong, New South Wales 2500 (Australia); Bode, F. [Medical Department II, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck 23562 (Germany); Liney, G. [Ingham Institute for Applied Medical Research, Liverpool Hospital, Liverpool, New South Wales 2170 (Australia); Hunold, P. [Department of Radiology and Nuclear Medicine, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck 23562 (Germany); Schweikard, A. [Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck 23562 (Germany); Keall, P. J., E-mail: paul.keall@sydney.edu.au [Radiation Physics Laboratory, Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006 (Australia)

    2014-12-15

    Purpose: Atrial fibrillation (AFib) is the most common cardiac arrhythmia that affects millions of patients world-wide. AFib is usually treated with minimally invasive, time consuming catheter ablation techniques. While recently noninvasive radiosurgery to the pulmonary vein antrum (PVA) in the left atrium has been proposed for AFib treatment, precise target location during treatment is challenging due to complex respiratory and cardiac motion. A MRI linear accelerator (MRI-Linac) could solve the problems of motion tracking and compensation using real-time image guidance. In this study, the authors quantified target motion ranges on cardiac magnetic resonance imaging (MRI) and analyzed the dosimetric benefits of margin reduction assuming real-time motion compensation was applied. Methods: For the imaging study, six human subjects underwent real-time cardiac MRI under free breathing. The target motion was analyzed retrospectively using a template matching algorithm. The planning study was conducted on a CT of an AFib patient with a centrally located esophagus undergoing catheter ablation, representing an ideal case for cardiac radiosurgery. The target definition was similar to the ablation lesions at the PVA created during catheter treatment. Safety margins of 0 mm (perfect tracking) to 8 mm (untracked respiratory motion) were added to the target, defining the planning target volume (PTV). For each margin, a 30 Gy single fraction IMRT plan was generated. Additionally, the influence of 1 and 3 T magnetic fields on the treatment beam delivery was simulated using Monte Carlo calculations to determine the dosimetric impact of MRI guidance for two different Linac positions. Results: Real-time cardiac MRI showed mean respiratory target motion of 10.2 mm (superior–inferior), 2.4 mm (anterior–posterior), and 2 mm (left–right). The planning study showed that increasing safety margins to encompass untracked respiratory motion leads to overlapping structures even in the

  1. Radiotherapy beyond cancer: target localization in real-time MRI and treatment planning for cardiac radiosurgery.

    Science.gov (United States)

    Ipsen, S; Blanck, O; Oborn, B; Bode, F; Liney, G; Hunold, P; Rades, D; Schweikard, A; Keall, P J

    2014-12-01

    Atrial fibrillation (AFib) is the most common cardiac arrhythmia that affects millions of patients world-wide. AFib is usually treated with minimally invasive, time consuming catheter ablation techniques. While recently noninvasive radiosurgery to the pulmonary vein antrum (PVA) in the left atrium has been proposed for AFib treatment, precise target location during treatment is challenging due to complex respiratory and cardiac motion. A MRI linear accelerator (MRI-Linac) could solve the problems of motion tracking and compensation using real-time image guidance. In this study, the authors quantified target motion ranges on cardiac magnetic resonance imaging (MRI) and analyzed the dosimetric benefits of margin reduction assuming real-time motion compensation was applied. For the imaging study, six human subjects underwent real-time cardiac MRI under free breathing. The target motion was analyzed retrospectively using a template matching algorithm. The planning study was conducted on a CT of an AFib patient with a centrally located esophagus undergoing catheter ablation, representing an ideal case for cardiac radiosurgery. The target definition was similar to the ablation lesions at the PVA created during catheter treatment. Safety margins of 0 mm (perfect tracking) to 8 mm (untracked respiratory motion) were added to the target, defining the planning target volume (PTV). For each margin, a 30 Gy single fraction IMRT plan was generated. Additionally, the influence of 1 and 3 T magnetic fields on the treatment beam delivery was simulated using Monte Carlo calculations to determine the dosimetric impact of MRI guidance for two different Linac positions. Real-time cardiac MRI showed mean respiratory target motion of 10.2 mm (superior-inferior), 2.4 mm (anterior-posterior), and 2 mm (left-right). The planning study showed that increasing safety margins to encompass untracked respiratory motion leads to overlapping structures even in the ideal scenario, compromising

  2. Stakeholder e-Participation in Local Planning: The Camargue Park Case

    Science.gov (United States)

    Desquinabo, Nicolas; Ferrand, Nils; Marlier, Julie

    The goal of this study is to evaluate several features and outcomes of the e-consultation organized by the Camargue Natural Park on its management plan. To estimate the benefits of the selected Internet devices, we have compared our assessment of this e-consultation with other face-to-face participative events organized on the same management plan. Following "computer-mediated communication" and deliberative theories, we expected that the tested e-tools would increase the deliberative features of the stakeholder participation. Several economic and organisational benefits were also expected. Our first results confirm the organisational benefits of this e-consultation (information gain, cost of the process, etc.). Several "deliberative" benefits have also been observed (more opinion and thematic diversity without an increase of "flames"). Nevertheless, speech is apparently more concentrated than in face-to-face events, even if many "non-posters" visited the consultation site but did not post because they had "all their comments already included".

  3. Corrective Action Plan for Corrective Action Unit 428: Area 3 Septic Waste Systems 1 and 5 Tonopah Test Range, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    D. S. Tobiason

    2000-01-01

    Area 3 Septic Waste Systems 1 and 5 are located in Area 3 of the Tonopah Test Range (TTR) (Figure 1). The site is listed in the Federal Facility Agreement and Consent Order (FFACO, 1996) as Corrective Action Unit (CAU) 428 and includes Corrective Action Sites 03-05-002-SW01 (Septic Waste System 1[SWS 1]), and 03-05-002-SW05 (Septic Waste System 5[SWS 5]). The site history for the CAU is provided in the Corrective Action Investigation Plan (U.S. Department of Energy, Nevada Operations Office[DOE/NV], 1999). SWS 1 consists of two leachfields and associated septic tanks. SWS 1 received effluent from both sanitary and industrial sources from various buildings in Area 3 of the TTR (Figure 2). SWS 5 is comprised of one leachfield and outfall with an associated septic tank. SWS 5 received effluent from sources in Building 03-50 in Area 3 of the TTR (Figure 2). Both systems were active until 1990 when a consolidated sewer system was installed. The purpose of this Corrective Action Plan (CAP) is to provide the strategy and methodology to close the Area 3 SWS 1 and 5. The CAU will be closed following state and federal regulations and the FFACO (1996). Site characterization was done during May and June 1999. Samples of the tank contents, leachfield soil, and soil under the tanks and pipes were collected. The results of the characterization were reported in the Corrective Action Decision Document (CADD) (DOE/NV, 2000). Additional sampling was done in May 2000, the results of which are presented in this plan. Soil sample results indicated that two constituents of concern were detected above Preliminary Action Levels (PALs). Total arsenic was detected at a concentration of 68.7 milligrams per kilogram (mg/kg). The arsenic was found under the center distribution line at the proximal end of the SWS 5 Leachfield (Figure 3). Total benzo(a)pyrene was detected at a concentration of 480 micrograms per kilogram ((micro)g/kg). The benzo(a)pyrene was found in the soil under the discharge

  4. Exploring Local Perspectives for Conservation Planning: A Case Study from a Remote Forest Community in Indonesian Papua

    Directory of Open Access Journals (Sweden)

    Miriam van Heist

    2015-09-01

    Full Text Available Reconciling conservation and livelihoods is a concern wherever forests are important in local people’s lives. We plead for engaging these people in survey activities to clarify what is important to them, as a first step in conservation planning. This will help to address their priorities and gain their guidance and support for interventions. This paper presents the results of such a survey with the community of Kwerba in Mamberamo, a remote and little known part of Indonesian Papua. Views and priorities were explored through interviews, scoring exercises, community mapping and a field survey. Whereas small gardens provided most staple food, culture and livelihoods were linked to the forest. People scored primary forest highest for nearly all use categories. Primary forest was particularly highly valued as a source of construction materials, ornaments and rituals, and as a hunting place. We developed a list of the overall most important plants and animals. Many natural resources were used, but few were commercially exploited. The community had rules to control access to certain areas and resources. Taboos to restrict access to sacred places were also maintained. Our evaluation identified opportunities to achieve conservation outcomes jointly with the Kwerba people. In follow-up activities, the community presented local government with a land-use plan for their territory. The government recognized the value of our approach and requested training to implement it more widely in the region.

  5. MAIN LAND USE PLANNING APPROACHES TO STRUCTURAL ELEMENTS LOCAL ECOLOGICAL NETWORK

    Directory of Open Access Journals (Sweden)

    TretiakV.M.

    2016-08-01

    Full Text Available In modern conditions of social development, changes in land eco-system of economic relations in Ukraine, the problem of providing conditions for the creation of sustainable land use and creation of protected areas get the status of special urgency. Ideology establishment of ecological networks became logical continuation of environmental thought in general. Considering the methodological approach to the establishment of ecological networks we can constitute, that it is an environmental frame of spatial infrastructure, land conservation and environmental areas, major part of land is the basis of the structural elements of ecological network. Designing an ecological network is made through developing regional schemes of Econet formation, regional and local schemes for establishing an ecological network areas, settlements and other areas. Land Management uses design of structural elements of the ecological network in the village council, as a rule, begins with ecological and landscape mikrozonationof the village council, held during the preparatory work for the land drafting and finishing the formation of environmentally homogeneous regions, which represents the tied system components of ecological network, environmental measures in the form of local environmental restrictions (encumbrances to use land and other natural resources. Additionally, there are some project organization and territorial measures that increase the sustainability area, such as: key, binders, buffer areas and renewable ecological network. Land management projects on the formation of structural elements of ecological network as territorial restrictions (encumbrances in land are used within the territories Councils determined the location and size of land: - Protection zones around especially valuable natural objects of cultural heritage, meteorological stations, etc. in order to protect them from adverse human impacts; - Protection zones along telecommunication lines, power

  6. Google walkability: a new tool for local planning and public health research?

    Science.gov (United States)

    Vargo, Jason; Stone, Brian; Glanz, Karen

    2012-07-01

    We investigate the association of different composite walkability measures with individual walking behaviors to determine if multicomponent metrics of walkability are more useful for assessing the health impacts of the built environment than single component measures. We use a previously published composite walkability measure as well as a new measure that was designed to represent easier methods of combination and which includes 2 metrics obtained using Google data sources. Logistic regression was used to assess the relationship between walking behavior and walkability metrics. Our results suggest that composite measures of walkability are more consistent predictors of walking behavior than single component measures. Furthermore, a walkability measure developed using free, publicly available data from Google was found to be nearly as effective in predicting walking outcomes as a walkability measure derived without such publicly and nationally available measures. Our findings demonstrate the effectiveness of free and locally relevant data for assessing walkable environments. This facilitates the use of locally derived and adaptive tools for evaluating the health impacts of the built environment.

  7. Sustainability Transitions at the Frontline. Lock-in and Potential for Change in the Local Planning Arena

    Directory of Open Access Journals (Sweden)

    Karolina Isaksson

    2018-03-01

    Full Text Available This paper explores challenges and possibilities for integrating goals of long-term sustainable development into urban planning practice, with a specific focus on local institutional conditions for sustainability transitions. The analysis is based on a qualitative single case study of a large urban development process: the development of a new city district in Hyllie in the city of Malmö, Sweden. Hyllie was branded as a flagship project for sustainable urban development, with particularly high ambitions on climate neutrality and sustainable energy consumption. Several innovative elements were initiated in the development process, for instance the “climate contract” between the municipality and large energy companies. In the paper, this climate contract is discussed as an initiative with a promising potential for sustainability transitions. In practice, however, the outcome of the development in Hyllie in terms of sustainable development is ambiguous, since the district is also framed around luxury shopping, entertainment, and an ambition to attract visitors from a long distance. The Hyllie development illustrates pre-requisites for work on sustainable development in a decentralized and market-oriented planning context. Theoretically, the analysis is inspired by the multi-level perspective (MLP and institutional theory. The results illustrate how the development process was shaped by a complex interplay between actors with differing agendas and targets at different stages in the process. These results are applied in a general discussion of challenges and possibilities for urban planning to contribute substantially to a transition to long-term sustainable development. Overall, the analysis demonstrates the importance of considering specific local institutional conditions in strategic work for long-term sustainability.

  8. Breastfeeding: Planning Ahead

    Medline Plus

    Full Text Available ... health topics Find Help Get breastfeeding help Get health care Get health insurance Get help with family planning ... health topics Find Help Get breastfeeding help Get health care Get health insurance Get help with family planning ...

  9. Corrective Action Investigation Plan for Corrective Action Unit 487: Thunderwell Site, Tonopah Test Range, Nevada (Rev. No.: 0, January 2001); TOPICAL

    International Nuclear Information System (INIS)

    2001-01-01

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) approach to collect the data necessary to evaluate corrective action alternatives (CAAs) appropriate for the closure of Corrective Action Unit (CAU) 487, Thunderwell Site, Tonopah Test Range (TTR), Nevada, under the Federal Facility Agreement and Consent Order. Corrective Action Unit 487 consists of a single Corrective Action Site (CAS), RG 26-001-RGRV, Thunderwell Site. The site is located in the northwest portion of the TTR, Nevada, approximately five miles northwest of the Area 3 Control Point and closest to the Cactus Flats broad basin. Historically, Sandia National Laboratories in New Mexico used CAU 487 in the early to mid-1960s for a series of high explosive tests detonated at the bottom of large cylindrical steel tubes. Historical photographs indicate that debris from these tests and subsequent operations may have been scattered and buried throughout the site. A March 2000 walk-over survey and a July 2000 geophysical survey indicated evidence of buried and surface debris in dirt mounds and areas throughout the site; however, a radiological drive-over survey also performed in July 2000 indicated that no radiological hazards were identified at this site. Based on site history, the scope of this plan is to resolve the problem statement identified during the Data Quality Objectives process that detonation activities at this CAU site may have resulted in the release of contaminants of concern into the surface/subsurface soil including total volatile and total semivolatile organic compounds, total Resource Conservation and Recovery Act metals, radionuclides, total petroleum hydrocarbons, and high explosives. Therefore, the scope of corrective action field investigation will involve excavation, drilling, and extensive soil sampling and analysis activities to determine the extent (if any) of both the lateral and vertical contamination and whether

  10. Integrated Modeling of the Human-Natural System to Improve Local Water Management and Planning

    Science.gov (United States)

    Gutowski, W. J., Jr.; Dziubanski, D.; Franz, K.; Goodwin, J.; Rehmann, C. R.; Simpkins, W. W.; Tesfastion, L.; Wanamaker, A. D.; Jie, Y.

    2015-12-01

    Communities across the world are experiencing the effects of unsustainable water management practices. Whether the problem is a lack of water, too much water, or water of degraded quality, finding acceptable solutions requires community-level efforts that integrate sound science with local needs and values. Our project develops both a software technology (agent-based hydrological modeling) and a social technology (a participatory approach to model development) that will allow communities to comprehensively address local water challenges. Using agent-based modeling (ABM), we are building a modeling system that includes a semi-distributed hydrologic process model coupled with agent (stakeholder) models. Information from the hydrologic model is conveyed to the agent models, which, along with economic information, determine appropriate agent actions that subsequently affect hydrology within the model. The iterative participatory modeling (IPM) process will assist with the continual development of the agent models. Further, IPM creates a learning environment in which all participants, including researchers, are co-exploring relevant data, possible scenarios and solutions, and viewpoints through continuous interactions. Our initial work focuses on the impact of flood mitigation and conservation efforts on reducing flooding in an urban area. We are applying all research elements above to the Squaw Creek watershed that flows through parts of four counties in central Iowa. The watershed offers many of the typical tensions encountered in Iowa, such as different perspectives on water management between upstream farmers and downstream urban areas, competition for various types of recreational services, and increasing absentee land ownership that may conflict with community values. Ultimately, climate change scenarios will be incorporated into the model to determine long term patterns that may develop within the social or natural system.

  11. Clinical Evaluation of Stereotactic Target Localization Using 3-Tesla MRI for Radiosurgery Planning

    International Nuclear Information System (INIS)

    MacFadden, Derek; Zhang Beibei; Brock, Kristy K.; Hodaie, Mojgan; Laperriere, Normand; Schwartz, Michael; Tsao, May; Stainsby, Jeffrey; Lockwood, Gina; Mikulis, David; Menard, Cynthia

    2010-01-01

    Purpose: Increasing the magnetic resonance imaging (MRI) field strength can improve image resolution and quality, but concerns remain regarding the influence on geometric fidelity. The objectives of the present study were to spatially investigate the effect of 3-Tesla (3T) MRI on clinical target localization for stereotactic radiosurgery. Methods and Materials: A total of 39 patients were enrolled in a research ethics board-approved prospective clinical trial. Imaging (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively analyzed in a representative cohort of patients with tumor (n = 4) and functional (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target volumes was determined by the mean discrepancy between the average gross target volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement from an averaged surface and volume congruency. Spatial congruency and the reproducibility of functional radiosurgical targets was determined by comparing the mean and standard deviation of the isocenter coordinates. Results: Overall, the mean absolute discrepancy across all patients was 0.67 mm (95% confidence interval, 0.51-0.83), significantly .4), and the gross target volume surface mean displacements were similar within and between users. The overall average isocenter coordinate discrepancy for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval, 0.20-0.48), with no patient-specific differences between the mean values (p >.2) or standard deviations (p >.1). Conclusion: Our results have provided clinically relevant evidence supporting the spatial validity of 3T MRI for use in stereotactic radiosurgery under the imaging conditions used.

  12. Topical report review status

    International Nuclear Information System (INIS)

    1997-08-01

    This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review schedules, of all topical reports currently accepted for review by the NRC. This report will be published annually. Each sponsoring organization with one or more topical reports accepted for review copies

  13. Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 425: Area 9 Main Lake Construction Debris Disposal Area, Tonopah Test Range, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    K. B. Campbell

    2002-01-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses the action necessary for the closure of Corrective Action Unit (CAU) 425, Area 9 Main Lake Construction Debris Disposal Area. This CAU is currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO, 1996). This site will be cleaned up under the SAFER process since the volume of waste exceeds the 23 cubic meters (m(sup 3)) (30 cubic yards[yd(sup 3)]) limit established for housekeeping sites. CAU 425 is located on the Tonopah Test Range (TTR) and consists of one Corrective Action Site (CAS) 09-08-001-TA09, Construction Debris Disposal Area (Figure 1). CAS 09-08-001-TA09 is an area that was used to collect debris from various projects in and around Area 9. The site is located approximately 81 meters (m) (265 feet[ft]) north of Edwards Freeway northeast of Main Lake on the TTR. The site is composed of concrete slabs with metal infrastructure, metal rebar, wooden telephone poles, and concrete rubble from the Hard Target and early Tornado Rocket sled tests. Other items such as wood scraps, plastic pipes, soil, and miscellaneous nonhazardous items have also been identified in the debris pile. It is estimated that this site contains approximately 2280 m(sup 3) (3000 yd(sup 3)) of construction-related debris

  14. Design and Evaluation of Reform Plan for Local Academic Nursing Challenges Using Action Research.

    Science.gov (United States)

    Asadizaker, Marziyeh; Abedsaeedi, Zhila; Abedi, Heidarali; Saki, Azadeh

    2016-12-01

    This study identifies challenges to the first nurse training program for undergraduate nursing students at a nursing and midwifery school in Iran using a collaborative approach in order to improve the program. Action research was used as a research strategy with qualitative content analysis and quantitative evaluation. The participants were 148 individuals from nursing academic and clinical settings, including administrators, faculty members, students, and staff nurses. We obtained approval from the research deputy and ethics committee of Shahid Beheshti University of Medical Sciences in Tehran, Iran for this study. Lack of coherence in the educational program and implementation of the program, inadequate communication between management inside and outside the organization, insufficient understanding of situations by students, and improper control of inhibitors and use of facilitators in teaching and in practice were among the major challenges in the first training process in the context of this study. After classification of problems, the educational decision-making authorities of the school developed an operational program with stakeholder cooperation to plan initial reforms, implementation of reforms, reflection about the actions, and evaluation. Comparison of student satisfaction with the collaborative learning process versus the traditional method showed that except for the atmosphere in the clinical learning environment (p>.05), the mean differences for all dimensions were statistically significant. The results confirm the overall success of the revised partnership program, but stressed the need for further modification of some details for its implementation in future rounds. Copyright © 2016. Published by Elsevier B.V.

  15. Street-level planning; the shifty nature of ‘local knowledge and practice’

    DEFF Research Database (Denmark)

    Vohnsen, Nina Holm

    2015-01-01

    The article explores and problematizes one of the oft-cited reasons why the implementation of public policy and other development initiatives goes wrong – namely that there is a mismatch or antagonistic relationship between street-level worker’s decisions and priorities on the one hand and on the...... descriptions of street-level workers as a distinct group of people with distinctive concerns and attitudes to their work.......The article explores and problematizes one of the oft-cited reasons why the implementation of public policy and other development initiatives goes wrong – namely that there is a mismatch or antagonistic relationship between street-level worker’s decisions and priorities on the one hand...... policy this articles suggests that when policy invariably is distorted at the administrative level it is not necessarily due to lack of will among street-level workers to comply with legislation or centrally devised directives but rather because a) in practice, planning and implementation are concurrent...

  16. Planning for increased bioenergy use-Evaluating the impact on local air quality

    International Nuclear Information System (INIS)

    Jonsson, Anna; Hillring, Bengt

    2006-01-01

    The Swedish energy system is undergoing a transformation due to threats about climate change and political decisions to reduce green house gases and to phase out the nuclear power. The goal is to convert the energy system from a system based on fossil fuels and nuclear power to one based on renewable energy sources. Bioenergy is an available domestic, renewable, carbon dioxide neutral energy source and therefore an increase of the use is forecasted in the future. Studies have shown that bioenergy may cause negative impacts on human health and on the environment due to emissions to air. The aim of this study was to investigate how a future conversion to bioenergy-based heating affect the air quality in residential areas. The contribution of particulate matter (PM 1 ) and benzene from existing heating systems as well as from conversion from electrical heating and firewood boilers to pellets and small-scale district heating systems was investigated. The investigations included monitoring of energy need for heating, identifying suitable energy systems for conversion, identifying emission factors, dispersion calculations and application of the results in a geographical information system (GIS). The results show that conversion from electrical heating to pellets in the investigated areas does not affect the air quality. The GIS maps showed the expected concentrations caused by small-scale combustion of bioenergy-based fuels clearly. The dispersion pattern of the emitted gases and particulates was visualized and the maps can be used for planning purposes when dealing with new residential areas

  17. Evaluating topic models with stability

    CSIR Research Space (South Africa)

    De Waal, A

    2008-11-01

    Full Text Available Topic models are unsupervised techniques that extract likely topics from text corpora, by creating probabilistic word-topic and topic-document associations. Evaluation of topic models is a challenge because (a) topic models are often employed...

  18. Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 330: Areas 6, 22, and 23 Tanks and Spill Sites, Nevada Test Site, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    T. M. Fitzmaurice

    2001-01-01

    This Streamlined Approach for Environmental restoration (SAFER) plan addresses the action necessary for the closure of Corrective Action Unit (CAU) 330, Areas 6,22, and 23 Tanks and Spill Sites. The CAUs are currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO). This CAU is located at the Nevada Test Site (NTS) (Figure 1). CAU 330 consists of the following Corrective Action Sites (CASs): (1) CAS 06-02-04 - Consists of an underground tank and piping. This CAS is close to an area that was part of the Animal Investigation Program (AIP), conducted under the U.S. Public Health Service. Its purpose was to study and perform tests on the cattle and wild animals in and around the NTS that were exposed to radionuclides. It is unknown if this tank was part of these operations. (2) CAS 22-99-06 - Is a fuel spill that is believed to be a waste oil release which occurred when Camp Desert Rock was an active facility. This CAS was originally identified as being a small depression where liquids were poured onto the ground, located on the west side of Building T-1001. This building has been identified as housing a fire station, radio station, and radio net remote and telephone switchboard. (3) CAS 23-01-02 - Is a large aboveground storage tank (AST) farm that was constructed to provide gasoline and diesel storage in Area 23. The site consists of two ASTs, a concrete foundation, a surrounding earthen berm, associated piping, and unloading stations. (4) CAS 23-25-05 - Consists of an asphalt oil spill/tar release that contains a wash covered with asphalt oil/tar material, a half buried 208-liter (L) (55-gallon[gal]) drum, rebar, and concrete located in the vicinity

  19. [Energy and environmental research emphasizing low-rank coal]: Task 7.1, Strategic planning. Topical report, February 1, 1994--June 30, 1995

    International Nuclear Information System (INIS)

    1996-01-01

    The nations of East Central Europe regained their political and economic freedom in 1989, ending nearly a half century of centrally planned economies under the hegemony of the former Soviet Union (FSU). These nations are now emerging from economic conditions marked by price distortions and a focus on heavy industry, isolation from world markets, and a lack of occupational health and environmental safeguards. Economic recovery, environmental restoration, and political stability, as well as eventual entrance into the European Community (EC), require a reordering of policies and priorities, including those bearing on energy and the environment. This report, prepared as a background document for the Second International Conference on Energy and Environment to be held in Prague in November 1994, is composed of a summary table (Table 1) and supporting text and is intended to provide a concise review of issues related to energy and the environment for the Czech and Slovak Republics, Hungary, Poland, and Bulgaria. Organized by subject and country, Table 1 contains country profiles (Row A), information on the economy (Row B), primary energy consumption, environmental priorities, energy resources, production, and utilization (Rows C, D, F, G, H, and I), electrical generation and transmission (Rows J and K), district heating (Row L), briquettes (Row M), and environmental regulations (Row N). Pertinent policy goals, issues, and trends are noted. The reports is based largely on a review of documents published by the International Energy Agency (IEA) and the U.S. Department of Energy (DOE), as well as selected sources obtained from the countries of the region. Reference citations are keyed to information presented in Table 1

  20. Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 326: Areas 6 and 27 Release Sites, Nevada Test Site, Nevada; TOPICAL

    International Nuclear Information System (INIS)

    A. T. Urbon

    2001-01-01

    This Streamlined Approach for Environmental Restoration (SAFER) plan addresses the action necessary for the closure of Corrective Action Unit (CAU) 326, Areas 6 and 27 Release Sites. This CAU is currently listed in the January 2001, Appendix III of the Federal Facilities Agreement and Consent Order (FFACO) (FFACO, 1996). CAU 326 is located on the Nevada Test Site (NTS) and consists of the following four Corrective Action Sites (CASS) (Figure 1): CAS 06-25-01-Is a rupture in an underground pipe that carried heating oil (diesel) from the underground heating oil tank (Tank 6-CP-1) located to the west of Building CP-70 to the boiler in Building CP-1 in the Area 6 Control Point (CP) compound. CAS 06-25-02-A heating oil spill that is a result of overfilling an underground heating oil tank (Tank 6-DAF-5) located at the Area 6 Device Assembly Facility (DAF). CAS 06-25-04-A release of waste oil that occurred while removing used oil to from Tank 6-619-4. Tank 6-619-4 is located northwest of Building 6-619 at the Area 6 Gas Station. CAS 27-25-01-Consists of an excavation that was created in an attempt to remove impacted stained soil from the Site Maintenance Yard in Area 27. Approximately 53.5 cubic meters (m(sup 3)) (70 cubic yards[yd(sup 3)]) of soil impacted by total petroleum hydrocarbons (TPH) and polychlorinated biphenyls (PCBs) was excavated before the excavation activities were halted. The excavation activities were stopped because the volume of impacted soil exceeded estimated quantities and budget

  1. British discretion in Dutch planning: establishing a comparative perspective for regional planning and local development in the Netherlands and the United Kingdom

    NARCIS (Netherlands)

    Janssen-Jansen, L.B.; Woltjer, J.

    2010-01-01

    Regional planning and development is continuing to take an important role in planning agendas throughout Europe. In the United Kingdom (UK), the planning system has been reformed during the last decades, marking a noticeable shift from a development-led towards a more plan-led system. In the

  2. SU-E-T-332: Dosimetric Impact of Photon Energy and Treatment Technique When Knowledge Based Auto-Planning Is Implemented in Radiotherapy of Localized Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Z; Kennedy, A [Sarah Cannon, Nashville, TN (United States); Larsen, E; Grow, A; Hayes, C; Balamucki, C [North Florida Cancer Center, Gainesville, FL (United States); Salmon, H; Thompson, M [Lake City Cancer Center, Lake City, FL (United States)

    2015-06-15

    Purpose: The aim of this study was to investigate the dosimetric impact of the combination of photon energy and treatment technique on radiotherapy of localized prostate cancer when knowledge based planning was used. Methods: A total of 16 patients with localized prostate cancer were retrospectively retrieved from database and used for this study. For each patient, four types of treatment plans with different combinations of photon energy (6X and 10X) and treatment techniques (7-field IMRT and 2-arc VMAT) were created using a prostate DVH estimation model in RapidPlan™ and Eclipse treatment planning system (Varian Medical System). For any beam arrangement, DVH objectives and weighting priorities were generated based on the geometric relationship between the OAR and PTV. Photon optimization algorithm was used for plan optimization and AAA algorithm was used for final dose calculation. Plans were evaluated in terms of the pre-defined dosimetric endpoints for PTV, rectum, bladder, penile bulb, and femur heads. A Student’s paired t-test was used for statistical analysis and p > 0.05 was considered statistically significant. Results: For PTV, V95 was statistically similar among all four types of plans, though the mean dose of 10X plans was higher than that of 6X plans. VMAT plans showed higher heterogeneity index than IMRT plans. No statistically significant difference in dosimetry metrics was observed for rectum, bladder, and penile bulb among plan types. For left and right femur, VMAT plans had a higher mean dose than IMRT plans regardless of photon energy, whereas the maximum dose was similar. Conclusion: Overall, the dosimetric endpoints were similar regardless of photon energy and treatment techniques when knowledge based auto planning was used. Given the similarity in dosimetry metrics of rectum, bladder, and penile bulb, the genitourinary and gastrointestinal toxicities should be comparable among the selections of photon energy and treatment techniques.

  3. Planning Target Volume D95 and Mean Dose Should Be Considered for Optimal Local Control for Stereotactic Ablative Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Lina [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhou, Shouhao [Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Balter, Peter [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Shen, Chan [Department of Health Service Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel R.; Welsh, James D.; Lin, Steve H. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y., E-mail: jychang@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2016-07-15

    Purpose: To identify the optimal dose parameters predictive for local/lobar control after stereotactic ablative radiation therapy (SABR) in early-stage non-small cell lung cancer (NSCLC). Methods and Materials: This study encompassed a total of 1092 patients (1200 lesions) with NSCLC of clinical stage T1-T2 N0M0 who were treated with SABR of 50 Gy in 4 fractions or 70 Gy in 10 fractions, depending on tumor location/size, using computed tomography-based heterogeneity corrections and a convolution superposition calculation algorithm. Patients were monitored by chest CT or positron emission tomography/CT and/or biopsy after SABR. Factors predicting local/lobar recurrence (LR) were determined by competing risk multivariate analysis. Continuous variables were divided into 2 subgroups at cutoff values identified by receiver operating characteristic curves. Results: At a median follow-up time of 31.7 months (interquartile range, 14.8-51.3 months), the 5-year time to local recurrence within the same lobe and overall survival rates were 93.8% and 44.8%, respectively. Total cumulative number of patients experiencing LR was 40 (3.7%), occurring at a median time of 14.4 months (range, 4.8-46 months). Using multivariate competing risk analysis, independent predictive factors for LR after SABR were minimum biologically effective dose (BED{sub 10}) to 95% of planning target volume (PTVD95 BED{sub 10}) ≤86 Gy (corresponding to PTV D95 physics dose of 42 Gy in 4 fractions or 55 Gy in 10 fractions) and gross tumor volume ≥8.3 cm{sup 3}. The PTVmean BED{sub 10} was highly correlated with PTVD95 BED{sub 10.} In univariate analysis, a cutoff of 130 Gy for PTVmean BED{sub 10} (corresponding to PTVmean physics dose of 55 Gy in 4 fractions or 75 Gy in 10 fractions) was also significantly associated with LR. Conclusions: In addition to gross tumor volume, higher radiation dose delivered to the PTV predicts for better local/lobar control. We recommend that both PTVD95 BED

  4. State and local governments plan for development of most land vulnerable to rising sea level along the US Atlantic coast

    International Nuclear Information System (INIS)

    Titus, J G; Hudgens, D E; Kassakian, J M; Trescott, D L; Craghan, M; Nuckols, W H; Hershner, C H; Linn, C J; Merritt, P G; McCue, T M; O'Connell, J F; Tanski, J; Wang, J

    2009-01-01

    Rising sea level threatens existing coastal wetlands. Overall ecosystems could often survive by migrating inland, if adjacent lands remained vacant. On the basis of 131 state and local land use plans, we estimate that almost 60% of the land below 1 m along the US Atlantic coast is expected to be developed and thus unavailable for the inland migration of wetlands. Less than 10% of the land below 1 m has been set aside for conservation. Environmental regulators routinely grant permits for shore protection structures (which block wetland migration) on the basis of a federal finding that these structures have no cumulative environmental impact. Our results suggest that shore protection does have a cumulative impact. If sea level rise is taken into account, wetland policies that previously seemed to comply with federal law probably violate the Clean Water Act.

  5. Postoperative localization of porta hepatis and abdominal vasculature in pancreatic malignancies: Implications for postoperative radiotherapy planning

    International Nuclear Information System (INIS)

    Kresl, John J.; Bonner, James A.; Bender, Claire E.; Grill, Joseph P.; Gunderson, Leonard L.

    1997-01-01

    Purpose: To evaluate changes in preoperative and postoperative positions of structures used to define target volumes (i.e., pancreatic bed, porta hepatis, local-regional lymph nodes) for postoperative irradiation of pancreatic malignancies as defined by abdominal computed tomographs. Methods and Materials: Eleven consecutive patients who had Whipple resection and postoperative irradiation for pancreatic cancer were evaluated. Preoperative and postoperative computed tomographs of each patient were evaluated for the position of the portal vein bifurcation and the origin of the celiac axis and superior mesenteric artery. The length along the x (medial-lateral position) and y (anterior-posterior position) axes was determined with calipers to the closest millimeter. Length along the z axis (cephalad-caudad position) was determined with the computed tomographic sectional interval between images. Statistical significance of the change in the structure's position along the x, y, or z axis between preoperative and postoperative computed tomographs was assessed with the paired t-test. Results: Evaluation of the preoperative and postoperative positions of the portal vein, celiac axis, and superior mesenteric artery along the x, y, and z axes revealed a statistically significant change in the location of the portal vein and celiac axis postoperatively. The median change of the celiac axis in the anterior-posterior position was significant (p = 0.0047), but the mean change was only 2 mm and not considered clinically significant. The median change for the portal vein was 0.97 cm and 1.07 cm along the y and x axes, respectively, and was significant (p = 0.008 and p = 0.0001). The range in position change for the portal vein was 0.0 to 2.0 cm along the y axis and 0.4 to 1.9 along the x axis. The remaining mean changes in position along all axes for all the structures were less than 3 mm (not statistically significant). Conclusions: The mean position of the portal vein

  6. Conservation planning on eroded land based of local wisdom in Kintamani sub-district, province of Bali

    Science.gov (United States)

    Sri Sumarniasih, Made; Antara, Made

    2017-01-01

    Location determination is based on the compilation of soil type’s map, land use map and slope map. Uniformity of soil type, slope and land use is classified into one unit of land, so that there are 48 units of land to be use as sample points. The purpose of this research are to identify patterns of land use, determine the amount of erosion, the amount of erosion that is tolerable and erosion control through a conservation plan based on local wisdom. The erosion prediction used USLE method, erosion of tolerated (Edp) using the formula Hammer. Results of laboratory and field observations having analyzed using USLE showed some level of erosion on land use in the Kintamani classified from very mild to very severe: 4.79 to 370.60 t ha-1yr-1, while Edp ranges from 30.00 to 48.00 t ha-1 yr-1. erosion Severe to very severe found on the use of mixed garden/citrus garden, dry land and shrubs/ reeds. The planned of use of land is intercropping annuals with horticultural crops (cabbage), citrus trees intercropped with flower of gumitir and bush land planting with elephant grass on a slope of less than 25% and planted of trees on land with a slope above 25%.

  7. Cancer--Living with Cancer: MedlinePlus Health Topic

    Science.gov (United States)

    ... during cancer treatment (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cancer--Living with ... care plan Show More Show Less Related Health Topics Cancer Cancer Chemotherapy Palliative Care National Institutes of ...

  8. Intensity-Modulated Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer: A Dose-Escalation Planning Study

    International Nuclear Information System (INIS)

    Lievens, Yolande; Nulens, An; Gaber, Mousa Amr; Defraene, Gilles; De Wever, Walter; Stroobants, Sigrid; Van den Heuvel, Frank

    2011-01-01

    Purpose: To evaluate the potential for dose escalation with intensity-modulated radiotherapy (IMRT) in positron emission tomography-based radiotherapy planning for locally advanced non-small-cell lung cancer (LA-NSCLC). Methods and Materials: For 35 LA-NSCLC patients, three-dimensional conformal radiotherapy and IMRT plans were made to a prescription dose (PD) of 66 Gy in 2-Gy fractions. Dose escalation was performed toward the maximal PD using secondary endpoint constraints for the lung, spinal cord, and heart, with de-escalation according to defined esophageal tolerance. Dose calculation was performed using the Eclipse pencil beam algorithm, and all plans were recalculated using a collapsed cone algorithm. The normal tissue complication probabilities were calculated for the lung (Grade 2 pneumonitis) and esophagus (acute toxicity, grade 2 or greater, and late toxicity). Results: IMRT resulted in statistically significant decreases in the mean lung (p <.0001) and maximal spinal cord (p = .002 and 0005) doses, allowing an average increase in the PD of 8.6-14.2 Gy (p ≤.0001). This advantage was lost after de-escalation within the defined esophageal dose limits. The lung normal tissue complication probabilities were significantly lower for IMRT (p <.0001), even after dose escalation. For esophageal toxicity, IMRT significantly decreased the acute NTCP values at the low dose levels (p = .0009 and p <.0001). After maximal dose escalation, late esophageal tolerance became critical (p <.0001), especially when using IMRT, owing to the parallel increases in the esophageal dose and PD. Conclusion: In LA-NSCLC, IMRT offers the potential to significantly escalate the PD, dependent on the lung and spinal cord tolerance. However, parallel increases in the esophageal dose abolished the advantage, even when using collapsed cone algorithms. This is important to consider in the context of concomitant chemoradiotherapy schedules using IMRT.

  9. Women's Health Topics

    Science.gov (United States)

    ... Information by Audience For Women Women's Health Topics Women's Health Topics Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print National Women's Health Week May 13 - 19, 2018 Join us ...

  10. Regulatory Information By Topic

    Science.gov (United States)

    EPA develops and enforces regulations that span many environmental topics, from acid rain reduction to wetlands restoration. Each topic listed below may include related laws and regulations, compliance enforcement information, policies guidance

  11. Responsibilities and Limits of Local Government Actions against Users of Public Services of Planning and Sustainable Territorial Development in Romania

    Directory of Open Access Journals (Sweden)

    Bogdan Suditu

    2014-02-01

    Full Text Available In the context of the changes that have occurred in the Romanian society, the public authorities are required to play a coordinating role in providing the framework for a sustainable and balanced development of the national territory, and to ensure the quality of life of the citizens. In order to achieve these goals of social responsibility, the public administration authorities must build and adapt the tools of public territorial action based on their specificity and within the existing legal framework and resources,. Thus, the study shows the national and European context that frames the actions of public administration for what concerns the sustainable territorial development. It analyzes the characteristics of administrative-territorial structures of Romania, highlighting their socio-demographic diversity and the territorial forms of institutional cooperation. The approach of these issues is based in the first instance on an analysis of the European strategic documents in the field, as well as on the national regulations concerning the organization and functioning of public administration and territorial planning. The implementation of decentralization and local public autonomy has led to the capitalization of the local potential of some administrative divisions and caused a competition and a difficult cooperation between them. By analogy with the provisions of the quality standards regarding the responsibilities of the organizations towards customers, the study illustrates and analyzes the responsibilities and limits of public administration authorities in promoting sustainable development, territorial equity and the quality of life for the users of public services, i.e. the community members.

  12. Understanding the Collaborative Planning Process in Homeless Services: Networking, Advocacy, and Local Government Support May Reduce Service Gaps.

    Science.gov (United States)

    Jarpe, Meghan; Mosley, Jennifer E; Smith, Bikki Tran

    2018-06-07

    The Continuum of Care (CoC) process-a nationwide system of regional collaborative planning networks addressing homelessness-is the chief administrative method utilized by the US Department of Housing and Urban Development to prevent and reduce homelessness in the United States. The objective of this study is to provide a benchmark comprehensive picture of the structure and practices of CoC networks, as well as information about which of those factors are associated with lower service gaps, a key goal of the initiative. A national survey of the complete population of CoCs in the United States was conducted in 2014 (n = 312, 75% response rate). This survey is the first to gather information on all available CoC networks. Ordinary least squares (OLS) regression was used to determine the relationship between internal networking, advocacy frequency, government investment, and degree of service gaps for CoCs of different sizes. United States. Lead contacts for CoCs (n = 312) that responded to the 2014 survey. Severity of regional service gaps for people who are homeless. Descriptive statistics show that CoCs vary considerably in regard to size, leadership, membership, and other organizational characteristics. Several independent variables were associated with reduced regional service gaps: networking for small CoCs (β = -.39, P < .05) and local government support for midsized CoCs (β = -.10, P < .05). For large CoCs, local government support was again significantly associated with lower service gaps, but there was also a significant interaction effect between advocacy and networking (β = .04, P < .05). To reduce service gaps and better serve the homeless, CoCs should consider taking steps to improve networking, particularly when advocacy is out of reach, and cultivate local government investment and support.

  13. Freshman Health Topics

    Science.gov (United States)

    Hovde, Karen

    2011-01-01

    This article examines a cluster of health topics that are frequently selected by students in lower division classes. Topics address issues relating to addictive substances, including alcohol and tobacco, eating disorders, obesity, and dieting. Analysis of the topics examines their interrelationships and organization in the reference literature.…

  14. When it is unfamiliar to me: Local acceptance of planned nuclear power plants in China in the post-fukushima era

    International Nuclear Information System (INIS)

    Guo, Yue; Ren, Tao

    2017-01-01

    Many contributions have been made in the studies of the factors that influence public acceptance of nuclear power. However, previous studies seldom focused on nuclear power plants in the planning stage. Actually public perception is usually more sensitive at the preliminary planning stage of a nuclear power station. Mainly utilizing questionnaire survey and focus group methods, we have identified the factors that are correlated with local acceptance of planned nuclear power plants in China. We conducted our survey in two cities, Huludao, Liaoning province in northern China, and Shanwei, Guangdong province in southern China, where the local government was planning to build its first nuclear power plant. We find that people who live closer to the plant sites are less willing to accept nuclear power than those who live farther away. As for “surface psychology” factors, perceived benefits and risks significantly influence local acceptance. As for “deep psychology” factors, emotional identification and social trust can significantly influence local acceptance, while perceived knowledge cannot. When citizens are unfamiliar with nuclear power plants, they are more inclined to evaluate the benefits and risks through emotional identification and social trust, rather than through pure rational deduction based on concrete facts. - Highlights: • We focus on the local acceptance of nuclear power in the planning stages. • People who live closer to plant sites are less willing to accept nuclear power. • Perceived benefits and risks significantly influence local acceptance. • Emotional identification and trust can significantly influence local acceptance. • While perceived knowledge cannot significantly influence local acceptance.

  15. Advanced verification topics

    CERN Document Server

    Bhattacharya, Bishnupriya; Hall, Gary; Heaton, Nick; Kashai, Yaron; Khan Neyaz; Kirshenbaum, Zeev; Shneydor, Efrat

    2011-01-01

    The Accellera Universal Verification Methodology (UVM) standard is architected to scale, but verification is growing and in more than just the digital design dimension. It is growing in the SoC dimension to include low-power and mixed-signal and the system integration dimension to include multi-language support and acceleration. These items and others all contribute to the quality of the SOC so the Metric-Driven Verification (MDV) methodology is needed to unify it all into a coherent verification plan. This book is for verification engineers and managers familiar with the UVM and the benefits it brings to digital verification but who also need to tackle specialized tasks. It is also written for the SoC project manager that is tasked with building an efficient worldwide team. While the task continues to become more complex, Advanced Verification Topics describes methodologies outside of the Accellera UVM standard, but that build on it, to provide a way for SoC teams to stay productive and profitable.

  16. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct....... The grammatical relation of the topic is expressed by a voice-like inflection of the verb, here called orientation. While subject-orientation is morphologically unmarked, object-oriented and adjunct-oriented verbs are marked by a subject suffix or by a suffix indicating that the topic is not subject, and adjunct......-orientation differs from object-orientation by a marked tone pattern. Topic choice largely reflects information structure by indicating topic continuity. The topic also plays a crucial role in relative clauses and in clauses with contrastive constituent focus, in that objects and adjuncts can only be relativized...

  17. How to build science-action partnerships for local land-use planning and management: lessons from Durban, South Africa

    Directory of Open Access Journals (Sweden)

    Jessica Cockburn

    2016-03-01

    Full Text Available The gap between scientific knowledge and implementation in the fields of biodiversity conservation, environmental management, and climate change adaptation has resulted in many calls from practitioners and academics to provide practical solutions responding effectively to the risks and opportunities of global environmental change, e.g., Future Earth. We present a framework to guide the implementation of science-action partnerships based on a real-world case study of a partnership between a local municipality and an academic institution to bridge the science-action gap in the eThekwini Municipal Area, South Africa. This partnership aims to inform the implementation of sustainable land-use planning, biodiversity conservation, environmental management, and climate change adaptation practice and contributes to the development of human capacity in these areas of expertise. Using a transdisciplinary approach, implementation-driven research is being conducted to develop several decision-making products to better inform land-use planning and management. Lessons learned through this partnership are synthesized and presented as a framework of enabling actions operating at different levels, from the individual to the interorganizational. Enabling actions include putting in place enabling organizational preconditions, assembling a functional well-structured team, and actively building interpersonal and individual collaborative capacity. Lessons learned in the case study emphasize the importance of building collaborative capacity and social capital, and paying attention to the process of transdisciplinary research to achieve more tangible science, management, and policy objectives in science-action partnerships. By documenting and reflecting on the process, this case study provides conceptual and practical guidance on bridging the science-action gap through partnerships.

  18. The industrial city and its structural changes in local plans on the example of Ruda Śląska, Poland

    Directory of Open Access Journals (Sweden)

    Rysz Kamil

    2015-09-01

    Full Text Available In the modern world, the subject of spatial planning is being increasingly raised by residents of municipalities - mainly because of the lack of a direct influence on the process of local development and aesthetics of the surroundings. Today, the primary objective of spatial planning is not only to form a proper connection between function and space but also to balance public and private interests. Constantly developed geographic spatial information systems allow not only for easy navigation around the city, but more importantly for more advanced analyses, such as the recognition of the current trends in estate development, communication systems, changes in agricultural and forest areas. The main objective of the research is to define functional-spatial links determined by social-economic needs reflected in local plans and to verify the similarities between local plans, that were drawn up in three different periods (PRL, the transition period, and in accordance with nowadays applicable laws, how the changing economic, social goals and current needs of the city affected the continuation of the adopted solutions. The study shows that despite changes in the law and abandoning the idea of industrial city, in which the landscape is dominated by blast furnaces and mine shafts, the basic trend has been maintained and local plans prepared in subsequent years form a continuum, and despite the different scales of development are closely linked. At the same time it has been shown that modern GIS tools enable verification of the continuity of spatial policy of the municipality.

  19. A spatial framework for targeting urban planning for pollinators and people with local stakeholders: A route to healthy, blossoming communities?

    Science.gov (United States)

    Bellamy, Chloe C; van der Jagt, Alexander P N; Barbour, Shelley; Smith, Mike; Moseley, Darren

    2017-10-01

    Pollinators such as bees and hoverflies are essential components of an urban ecosystem, supporting and contributing to the biodiversity, functioning, resilience and visual amenity of green infrastructure. Their urban habitats also deliver health and well-being benefits to society, by providing important opportunities for accessing nature nearby to the homes of a growing majority of people living in towns and cities. However, many pollinator species are in decline, and the loss, degradation and fragmentation of natural habitats are some of the key drivers of this change. Urban planners and other practitioners need evidence to carefully prioritise where they focus their resources to provide and maintain a high quality, multifunctional green infrastructure network that supports pollinators and people. We provide a modelling framework to inform green infrastructure planning as a nature based solution with social and ecological benefits. We show how habitat suitability models (HSM) incorporating remote sensed vegetation data can provide important information on the influence of urban landcover composition and spatial configuration on species distributions across cities. Using Edinburgh, Scotland, as a case study city, we demonstrate this approach for bumble bees and hoverflies, providing high resolution predictive maps that identify pollinator habitat hotspots and pinch points across the city. By combining this spatial HSM output with health deprivation data, we highlight 'win-win' opportunity areas in most need of improved green infrastructure to support pollinator habitat quality and connectivity, as well as societal health and well-being. In addition, in collaboration with municipal planners, local stakeholders, and partners from a local greenspace learning alliance, we identified opportunities for citizen engagement activities to encourage interest in wildlife gardening as part of a 'pollinator pledge'. We conclude that this quantitative, spatially explicit and

  20. Topical report review status

    International Nuclear Information System (INIS)

    1982-08-01

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  1. Topical report review status

    International Nuclear Information System (INIS)

    1983-01-01

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  2. Interaction between Cities and Climate Change: Modelling Urban Morphology and Local Urban Planning Scenarios from Open Datasets across European Cities

    Science.gov (United States)

    Thomas, Bart; Stevens, Catherine; Grommen, Mart

    2015-04-01

    Cities are characterised by a large spatiotemporal diversity of local climates induced by a superposition of various factors and processes interacting at global and regional scales but also at the micro level such as the urban heat island effect. As urban areas are known as 'hot spots' prone to climate and its variability over time leading to changes in the severity and occurrence of extreme events such as heat waves, it is of crucial importance to capture the spatial heterogeneity resulting from variations in land use land cover (LULC) and urban morphology in an effective way to drive local urban climate simulations. The first part of the study conducted in the framework of the NACLIM FP7 project funded by the European Commission focusses on the extraction of land surface parameters linked to urban morphology characteristics from detailed 3D city models and their relationship with openly accessible European datasets such as the degree of soil sealing and disaggregated population densities from the European Environment Agency (EEA) and the Joint Research Centre (JRC). While it has been demonstrated that good correlations can be found between those datasets and the planar and frontal area indices, the present work has expanded the research to other urban morphology parameters including the average and variation of the building height and the sky view factor. Correlations up to 80% have been achieved depending on the considered parameter and the specific urban area including the cities of Antwerp (Belgium), Berlin (Germany) and Almada (Portugal) represented by different climate and urban characteristics. Moreover, the transferability of the established relations has been investigated across the various cities. Secondly, a flexible and scalable approach as a function of the required the level of detail has been elaborated to update the various morphology parameters in case of integration with urban planning data to analyse the local impact of future land use scenarios

  3. Modelo de Gestión de un Plan de Desarrollo Productivo Local. El Caso de Nova Friburgo, Brasil

    Directory of Open Access Journals (Sweden)

    Moré Jesús D.

    2010-11-01

    Full Text Available La presente investigación trata del análisis del impacto de la innovación en las deficiencias que aparecen listadas en el Plan de Desarrollo del Sistema Productivo Local (SPL de Moda Íntima de Nova Friburgo, según la percepción de su Administración. Inicialmente fueron investigadas las principales ideas de la Administración del SPL sobre las  innovaciones y nuevas tecnologías. Primeramente en función del desempeño de los factores que influyen en el desarrollo del SPL (fundamentalmente las innovaciones y las nuevas tecnologías y seguidamente a partir de la influencia de esos factores en las deficiencias presentes en el SPL. Cinco gestores de la Administración fueron sometidos a tres cuestionarios estructurados. Las respuestas, llevadas para un formato numérico, originaron un indicador de impacto relativo el cual fue utilizado para evaluar el impacto que podrían tener las innovaciones en las deficiencias mencionadas. Los resultados de la investigación sugieren  que el proceso de innovación posee un débil desempeño en el SPL y ejerce un impacto bajo cuando se trata de atenuar las deficiencias de este.

  4. Local Environmental Action Plan in Republic of Macedonia. Executive summaries of municipalities of Centar, Zrnovci, Veles and Gevgelija

    International Nuclear Information System (INIS)

    1998-06-01

    The report aims at assessing the progress in adopting comprehensive environmental protection strategies at the local level. The whole project was carried out by the Regional Environmental Center for Central and Eastern Europe (REC) in collaboration with the Ministry for Urban Planning, Construction and Environmental of Republic of Macedonia (MUPCE). The REC and MUPCE identified four different municipalities to develop different modules of LEAPs with using the same methodology approach, which can be used as a pilot projects for other, more than hundred municipalities in Macedonia. These municipalities are: 1) Centar - one of the seven municipalities in the city Skopje, which occupies central part of the capital of Macedonia, as a typical urban area; 2) Veles as a typical industrial area, situated in the central part of the Republic of Macedonia, and considered as the most polluted region in the country; 3) Zrnovci - situated in the eastern part of Macedonia, a typical agricultural area, mainly for rice production; 4) Gevgelija as a transboundary and transit area

  5. Clinical Implementation of an Online Adaptive Plan-of-the-Day Protocol for Nonrigid Motion Management in Locally Advanced Cervical Cancer IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Heijkoop, Sabrina T., E-mail: s.heijkoop@erasmusmc.nl; Langerak, Thomas R.; Quint, Sandra; Bondar, Luiza; Mens, Jan Willem M.; Heijmen, Ben J.M.; Hoogeman, Mischa S.

    2014-11-01

    Purpose: To evaluate the clinical implementation of an online adaptive plan-of-the-day protocol for nonrigid target motion management in locally advanced cervical cancer intensity modulated radiation therapy (IMRT). Methods and Materials: Each of the 64 patients had four markers implanted in the vaginal fornix to verify the position of the cervix during treatment. Full and empty bladder computed tomography (CT) scans were acquired prior to treatment to build a bladder volume-dependent cervix-uterus motion model for establishment of the plan library. In the first phase of clinical implementation, the library consisted of one IMRT plan based on a single model-predicted internal target volume (mpITV), covering the target for the whole pretreatment observed bladder volume range, and a 3D conformal radiation therapy (3DCRT) motion-robust backup plan based on the same mpITV. The planning target volume (PTV) combined the ITV and nodal clinical target volume (CTV), expanded with a 1-cm margin. In the second phase, for patients showing >2.5-cm bladder-induced cervix-uterus motion during planning, two IMRT plans were constructed, based on mpITVs for empty-to-half-full and half-full-to-full bladder. In both phases, a daily cone beam CT (CBCT) scan was acquired to first position the patient based on bony anatomy and nodal targets and then select the appropriate plan. Daily post-treatment CBCT was used to verify plan selection. Results: Twenty-four and 40 patients were included in the first and second phase, respectively. In the second phase, 11 patients had two IMRT plans. Overall, an IMRT plan was used in 82.4% of fractions. The main reasons for selecting the motion-robust backup plan were uterus outside the PTV (27.5%) and markers outside their margin (21.3%). In patients with two IMRT plans, the half-full-to-full bladder plan was selected on average in 45% of the first 12 fractions, which was reduced to 35% in the last treatment fractions. Conclusions: The implemented

  6. The implementation goals of geoinformation support to planning and spatial management at the local level in the framework of the ONIX project

    Directory of Open Access Journals (Sweden)

    Franc J. Zakrajšek

    1999-01-01

    Full Text Available The project objective is to strengthen the development, establishment, maintenance and use of the geographical data bases in the processes of physical planning and urban management on local level. It is a part of the Slovenian environmental project Onix. The current state is the phase of implementation.

  7. Dosimetric study of RapidArc plans with flattened beam (FB and flattening filter-free (FFF beam for localized prostate cancer based on physical indices

    Directory of Open Access Journals (Sweden)

    Birendra Kumar Rout

    2014-12-01

    Full Text Available Purpose: To identify the continual diversity between flattening photon beam (FB and Flattening Filter Free (FFF photon beams for localized prostate cancer; and to determine potential benefits and drawbacks of using unflattened beam for this type of treatment.Methods: Eight prostate cases including seminal vesicles selected for this study. The primary planning target volume (PTVP and boost planning target volume (PTVB were contoured. The total prescription dose was 78 Gy (56 Gy to PTVP and an additional 22 Gy to PTVB. For all cases, treatment plans using 6MV with FB and FFF beams with identical dose-volume constraints, arc angles and number of arcs were developed. The dose volume histograms for both techniques were compared for primary target volume and critical structures.Results: A low Sigma index (FFF: 1.65 + 0.361; FB: 1.725 + 0.39 indicating improved dose homogeneity in FFF beam. Conformity index (FFF: 0.994 + 0.01; FB: 0.993 + 0.01 is comparable for both techniques. Minimal difference of Organ at risk mean dose was observed. Normal tissue integral dose in FB plan resulted 1.5% lower than FFF plan. All the plans displayed significant increase (1.18 times for PTVP and 1.11 for PTBB in the average number of necessary MU with FFF beam.Conclusion: Diversity between FB and FFF beam plans were found. FFF beam accelerator has been utilized to develop clinically acceptable Rapid Arc treatment plans for prostate cancer with 6 MV.---------------------------------Cite this article as: Rout BK, Muralidhar KR, Ali M, Shekar MC, Kumar A. Dosimetric study of RapidArc plans with flattened beam (FB and flattening filter-free (FFF beam for localized prostate cancer based on physical indices. Int J Cancer Ther Oncol 2014; 2(4:02046.  DOI: 10.14319/ijcto.0204.6

  8. Building capacity in local government for integrated planning to increase physical activity: evaluation of the VicHealth MetroACTIVE program.

    Science.gov (United States)

    Thomas, M M; Hodge, W; Smith, B J

    2009-12-01

    Integrated planning is a holistic approach to addressing the needs of local communities built on partnerships between those responsible for development, environmental quality and service provision. This study investigated the extent and key influences on the use of integrated planning to promote physical activity among six metropolitan councils in Melbourne Australia, which took part in the MetroACTIVE Project funded by the Victorian Health Promotion Foundation from 2005 to 2007. The evaluation entailed interviews conducted at the mid-term (N = 67) and completion (N = 50) of the project, and the review of relevant documents. Respondents included elected councillors, chief executive officers, officers from different council divisions and the project staff employed in each council. Three councils showed evidence of integrated planning for physical activity, whereas the remainder focused on the delivery of community participation programs. Leadership from senior management and an organizational culture that supported collaboration across council departments were prerequisites for integrated planning. Employment of a dedicated project officer with skills for engaging management and building partnerships within the organization was important. Barriers to integrated planning were a complex organization structure, high demands on the council due to a growing residential population and a poor climate among staff. Overall, integrated planning was found to be a viable approach for developing a coordinated approach to this issue involving the range of council services and functions. Ongoing strategies are needed to facilitate senior management commitment and organizational capacity for integrated planning, with leadership provided by departments responsible for infrastructure or corporate planning.

  9. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    by Adam et al. In the paper by V Man'ko et al the diagonal representation of the density operator (usually called P-function of Glauber-Sudarshan) is related to the star-product quantization method and to the tomographic-probability representation of quantum states. Laskowski et al suggest an elegant geometrical criterion for the separability, which is based on the local correlation measurements readily available in the laboratory. Mizrahi describes a method to derive the Pauli-Schrödinger equation starting from a simple model of a qubit carried by a massive particle. By analyzing unavoidable quantum losses as they appear in neutron phase-echo and spin rotation experiments, Rauch concludes that basic quantum irreversibility exists in neutron interferometry. Rauch also shows how entanglement effects in a single particle system demonstrate quantum contextuality, and then argues that a quantum system carries much more information than is usually extracted. Kupczynski advocates various statistical tests which could be used to search for a fine structure in experimental data in order to answer the question: is quantum theory predictably complete? For an ion confined within a Paul trap, Mihalcea constructs an invariant operator based on the Lews and Riesenfeld approach and determines the spectrum of the quasienergy operator. Popov et al construct pair-coherent states of the Barut-Girardello kind for two noninteracting subsystems of pseudoharmonic oscillators and examine their statistical properties in different regions of parameters. The property of entanglement, considered to be the most intriguing property of composite quantum systems, has been an important research subject in recent years. It is considered to be a possible resource for quantum computation and communication. Therefore, a substantial number of papers in this topical issue is devoted to entanglement. Leon et al write that two-photon emission from two atoms initially excited in a common electromagnetic

  10. Adaptive/Nonadaptive Proton Radiation Planning and Outcomes in a Phase II Trial for Locally Advanced Non-small Cell Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Koay, Eugene J.; Lege, David [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y., E-mail: jychang@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2012-12-01

    Purpose: To analyze dosimetric variables and outcomes after adaptive replanning of radiation therapy during concurrent high-dose protons and chemotherapy for locally advanced non-small cell lung cancer (NSCLC). Methods and Materials: Nine of 44 patients with stage III NSCLC in a prospective phase II trial of concurrent paclitaxel/carboplatin with proton radiation [74 Gy(RBE) in 37 fractions] had modifications to their original treatment plans after re-evaluation revealed changes that would compromise coverage of the target volume or violate dose constraints; plans for the other 35 patients were not changed. We compared patients with adaptive plans with those with nonadaptive plans in terms of dosimetry and outcomes. Results: At a median follow-up of 21.2 months (median overall survival, 29.6 months), no differences were found in local, regional, or distant failure or overall survival between groups. Adaptive planning was used more often for large tumors that shrank to a greater extent (median, 107.1 cm{sup 3} adaptive and 86.4 cm{sup 3} nonadaptive; median changes in volume, 25.3% adaptive and 1.2% nonadaptive; P<.01). The median number of fractions delivered using adaptive planning was 13 (range, 4-22). Adaptive planning generally improved sparing of the esophagus (median absolute decrease in V{sub 70}, 1.8%; range, 0%-22.9%) and spinal cord (median absolute change in maximum dose, 3.7 Gy; range, 0-13.8 Gy). Without adaptive replanning, target coverage would have been compromised in 2 cases (57% and 82% coverage without adaptation vs 100% for both with adaptation); neither patient experienced local failure. Radiation-related grade 3 toxicity rates were similar between groups. Conclusions: Adaptive planning can reduce normal tissue doses and prevent target misses, particularly for patients with large tumors that shrink substantially during therapy. Adaptive plans seem to have acceptable toxicity and achieve similar local, regional, and distant control and overall

  11. Modern topics in electron scattering

    CERN Document Server

    Frois, Bernard

    1991-01-01

    This book summarizes the considerable progress recently achieved in the understanding of nucleon and nuclear structure by using high energy electrons as a probe. A collection of papers discusses in detail the new frontiers of this field. Experimental and theoretical articles cover topics such as the structure of the nucleon, nucleon distributions, many-body correlations, non-nucleonic degrees of freedom and few-body systems. This book is an up-to-date introduction to the research planned with continuous beam electron accelerators.

  12. Beyond defense-in-depth: cost and funding of state and local government radiological emergency response plans and preparedness in support of commercial nuclear power stations

    International Nuclear Information System (INIS)

    Salomon, S.N.

    1979-10-01

    Inadequate, sporadic, uncertain and frustrating are words local, state and Federal officials use to describe the current hodgepodge funding approach to State and local government radiological emergency response plans and preparedeness in support of commercial nuclear power stations. The creation of a Radiological Emergency Response Plans and Preparedness Fund for State and Local Government is offered as a preferred solution. Monies for the Fund could be derived from a one time Fee of $1 million levied on the operator of each nuclear power station. Every five years, adjustments could be made in the Fee to assure full recovery of costs because of inflation, revised criteria and other cost related factors. Any surplus would be refunded to the utilities. Any state that has obtained NRC concurrence or is in the process could be reimbursed for previous expenditures up to two years prior to NRC concurrence. Concurrence in all state and local government plans is the objective of the funding program. The Fund should be administered by the Nuclear Regulatory Commission. The report also discusses actions by Federal and state agencies and points to long range considerations, such as a training institute, including transportation and non-commercial and other fixed nuclear facilities, where preparedness could be enhanced by a coherent funding mechanism. All recommendations are based on an inquiry by the Office of state Programs, NRC, into the historical and future costs and funding of radiological emergency response plans and preparedness at the state and local government levels and are derived from discussions with many local, State and Federal officials

  13. Daily online localization using implanted fiducial markers and its impact on planning target volume for carcinoma prostate.

    Science.gov (United States)

    Khosa, Robin; Nangia, Sapna; Chufal, Kundan S; Ghosh, D; Kaul, Rakesh; Sharma, Lalit

    2010-01-01

    Aim of the study was to assess prostate motion on daily basis with respect to setup and to compare the shifts based on bony anatomy and gold fiducial markers. Gold fiducial markers were inserted in prostate under U/S guidance and daily portal images were taken and compared with digitally reconstructed images, both using bony landmarks and fiducial markers as reference. A dose of 2 MU was given for two orthogonal images daily. The mean and standard deviation of displacement using gold seeds and bone were calculated. Systematic and random errors were generated. The planning target volume (PTV) was calculated using the Van Herk formula. A total of 180 portal images from 10 patients were studied. The mean displacement along x, y and z axes was 1.67 mm, 3.58 mm, and 1.76 mm using fiducial markers and 2.12 mm, 3.47 mm, and 2.09 mm using bony landmarks, respectively. The mean internal organ motion was 1.23 mm (+1.45), 3.11 mm (+2.69 mm); and 1.87 mm (+1.67 mm) along x, y and z axes, respectively. The PTV to account for prostate motion if daily matching was not done was 4.64 mm, 10.41 mm and 4.40 mm along lateral, superoinferior, and anteroposterior directions, respectively. If bony landmarks were used for daily matching, margins of 3.61 mm, 7.31 mm, and 4.72 mm in lateral, superoinferior, and anteroposterior directions should be added to the clinical target volume. Daily alignment using gold fiducial markers is an effective method of localizing prostate displacement. It provides the option of reducing margins, thus limiting normal tissue toxicity and allowing the possibility of dose escalation for better long-term control.

  14. Land Use and Land Cover, Existing land use derived from orthoimagery. Ground-truthing from discussion with local plan commission members., Published in 2000, 1:12000 (1in=1000ft) scale, Portage County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Land Use and Land Cover dataset current as of 2000. Existing land use derived from orthoimagery. Ground-truthing from discussion with local plan commission members..

  15. Dosimetry: an ARDENT topic

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    The first annual ARDENT workshop took place in Vienna from 20 to 23 November. The workshop gathered together the Early-Stage Researchers (ESR) and their supervisors, plus other people involved from all the participating institutions.   “The meeting, which was organised with the local support of the Austrian Institute of Technology, was a nice opportunity for the ESRs to get together, meet each other, and present their research plans and some preliminary results of their work,” says Marco Silari, a member of CERN Radiation Protection Group and the scientist in charge of the programme. Two full days were devoted to a training course on radiation dosimetry, delivered by renowned experts. The workshop closed with a half-day visit to the MedAustron facility in Wiener Neustadt. ARDENT (Advanced Radiation Dosimetry European Network Training) is a Marie Curie ITN project funded under EU FP7 with €4 million. The project focuses on radiation dosimetry exploiting se...

  16. Diclofenac Topical (osteoarthritis pain)

    Science.gov (United States)

    ... gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining ... Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a ...

  17. Diclofenac Topical (actinic keratosis)

    Science.gov (United States)

    ... topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by ... The way diclofenac gel works to treat actinic keratosis is not known.Diclofenac is also available as ...

  18. Topics in Nuclear Astrophysics

    International Nuclear Information System (INIS)

    Chung, K.C.

    1982-01-01

    Some topics in nuclear astrophysics are discussed, e.g.: highly evolved stellar cores, stellar evolution (through the temperature analysis of stellar surface), nucleosynthesis and finally the solar neutrino problem. (L.C.) [pt

  19. SU-F-J-64: Comparison of Dosimetric Robustness Between Proton Therapy and IMRT Plans Following Tumor Regression for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

    Energy Technology Data Exchange (ETDEWEB)

    Teng, C; Ainsley, C; Teo, B; Burgdorf, B; Berman, A; Levin, W; Xiao, Y; Lin, L; Simone, C; Solberg, T [University of Pennsylvania, Philadelphia, PA (United States); Janssens, G [IBA, Louvain-la-Neuve (Belgium)

    2016-06-15

    Purpose: In the light of tumor regression and normal tissue changes, dose distributions can deviate undesirably from what was planned. As a consequence, replanning is sometimes necessary during treatment to ensure continued tumor coverage or to avoid overdosing organs at risk (OARs). Proton plans are generally thought to be less robust than photon plans because of the proton beam’s higher sensitivity to changes in tissue composition, suggesting also a higher likely replanning rate due to tumor regression. The purpose of this study is to compare dosimetric deviations between forward-calculated double scattering (DS) proton plans with IMRT plans upon tumor regression, and assesses their impact on clinical replanning decisions. Methods: Ten consecutive locally advanced NSCLC patients whose tumors shrank > 50% in volume and who received four or more CT scans during radiotherapy were analyzed. All the patients received proton radiotherapy (6660 cGy, 180 cGy/fx). Dosimetric robustness during therapy was characterized by changes in the planning objective metrics as well as by point-by-point root-mean-squared differences for the entire PTV, ITV, and OARs (heart, cord, esophagus, brachial plexus and lungs) DVHs. Results: Sixty-four pairs of DVHs were reviewed by three clinicians, who requested a replanning rate of 16.7% and 18.6% for DS and IMRT plans, respectively, with a high agreement between providers. Robustness of clinical indicators was found to depend on the beam orientation and dose level on the DVH curve. Proton dose increased most in OARs distal to the PTV along the beam path, but these changes were primarily in the mid to low dose levels. In contrast, the variation in IMRT plans occurred primarily in the high dose region. Conclusion: Robustness of clinical indicators depends where on the DVH curves comparisons are made. Similar replanning rates were observed for DS and IMRT plans upon large tumor regression.

  20. Superiority of conventional intensity-modulated radiotherapy over helical tomotherapy in locally advanced non-small cell lung cancer. A comparative plan analysis

    Energy Technology Data Exchange (ETDEWEB)

    Song, C. [National Cancer Center, Research Institute and Hospital, Goyang (Korea, Republic of). Proton Therapy Center; Seoul National Univ. College of Medicine (Korea, Republic of). Dept. of Radiation Oncology; Pyo, H.; Kim, J. [Sungkyunkwan Univ. School of Medicine, Samsung Medical Center, Seoul (Korea, Republic of). Dept. of Radiation Oncology; Lim, Y.K.; Kim, D.W.; Cho, K.H. [National Cancer Center, Research Institute and Hospital, Goyang (Korea, Republic of). Proton Therapy Center; Kim, W.C. [Inha Univ. School of Medicine, Incheon (Korea, Republic of). Dept. of Radiation Oncology; Kim, H.J. [Seoul National Univ. College of Medicine (Korea, Republic of). Dept. of Radiation Oncology

    2012-10-15

    Purpose: To compare helical tomotherapy (HT) and conventional intensity-modulated radiotherapy (IMRT) using a variety of dosimetric and radiobiologic indexes in patients with locally advanced non-small cell lung cancer (LA-NSCLC). Patients and methods: A total of 20 patients with LA-NSCLC were enrolled. IMRT plans with 4-6 coplanar beams and HT plans were generated for each patient. Dose distributions and dosimetric indexes for the tumors and critical structures were computed for both plans and compared. Results: Both modalities created highly conformal plans. They did not differ in the volumes of lung exposed to > 20 Gy of radiation. The average mean lung dose, volume receiving {>=} 30 Gy, and volume receiving {>=} 10 Gy in HT planning were 18.3 Gy, 18.5%, and 57.1%, respectively, compared to 19.4 Gy, 25.4%, and 48.9%, respectively, with IMRT (p = 0.004, p < 0.001, and p < 0.001). The differences between HT and IMRT in lung volume receiving {>=} 10-20 Gy increased significantly as the planning target volume (PTV) increased. For 6 patients who had PTV greater than 700 cm{sup 3}, IMRT was superior to HT for 5 patients in terms of lung volume receiving {>=} 5-20 Gy. The integral dose to the entire thorax in HT plans was significantly higher than in IMRT plans. Conclusion: HT gave significantly better control of mean lung dose and volume receiving {>=} 30-40 Gy, whereas IMRT provided better control of the lung volume receiving {>=} 5-15 Gy and the integral dose to entire thorax. In most patients with PTV greater than 700 cm{sup 3}, IMRT was superior to HT in terms of lung volume receiving {>=} 5-20 Gy. It is therefore advised that caution should be exercised when planning LA-NSCLC using HT. (orig.)

  1. Topical Drugs for Pain Relief

    Directory of Open Access Journals (Sweden)

    Anjali Srinivasan

    2015-03-01

    Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

  2. Local Action Plans for Forest Fire Prevention in Greece: Existing situation and a Proposed Template based on the Collaboration of Academics and Public Policy Makers

    Science.gov (United States)

    Papanikolaou, Dimitrios; Arvanitakis, Spyridon; Papanikolaou, , Ioannis; Lozios, Stylianos; Diakakis, Michalis; Deligiannakis, Georgios; Dimitropoulou, Margarita; Georgiou, Konstantinos

    2013-04-01

    Wildfires are a major hazard in Greece suffering on average 1,509 wildfires and 36,151 burned hectares of forestlands every year. Since 1998 the Greek Fire Service is responsible for wildfires suppression and response, while prevention and mitigation yearly directives are also being released by the General Secretariat of Civil Protection. The 3013/2002 Act introduced a major transfer of responsibilities from the national to local municipal and regional authorities, which are accompanied by supplementary financial support. Significant new features were established such as the operation of local coordination councils, the foundation of municipality civil protection offices, the establishment of the annually prevention planning for forest fires and the development of local action plans. The University of Athens has developed a Local Action Plan template for municipality administrative levels, integrating scientific techniques and technologies to public government management. The Local Action Plan for Forest Fire Prevention is the main handbook and primary tool of every municipality for reducing the risk of wildfires. Fire prevention and risk analysis are the principal aims of this Plan, which also emphasizes on the important role of the volunteer organizations on forest fire prevention. The 7 chapters of the Action Plan include the legal framework, the risk analysis parameters, the risk analysis using GIS, the prevention planning, the manpower and available equipment of services involved, along with operational planning and evaluation of the previous year's forest fire prevention actions. Multiple information layers, such as vegetation types, road network, power lines and landfills are combined in GIS environment and transformed into qualitative multiparameter as well as quantitative combinational fire hazard maps. These maps are essential in wildfire risk analysis as they display the areas that need the highest attention during the fire season. Moreover, the separate

  3. Responsibility without legal authority? Tackling alcohol-related health harms through licensing and planning policy in local government.

    Science.gov (United States)

    Martineau, F P; Graff, H; Mitchell, C; Lock, K

    2014-09-01

    The power to influence many social determinants of health lies within local government sectors that are outside public health's traditional remit. We analyse the challenges of achieving health gains through local government alcohol control policies, where legal and professional practice frameworks appear to conflict with public health action. Current legislation governing local alcohol control in England and Wales is reviewed and analysed for barriers and opportunities to implement effective population-level health interventions. Case studies of local government alcohol control practices are described. Addressing alcohol-related health harms is constrained by the absence of a specific legal health licensing objective and differences between public health and legal assessments of the relevance of health evidence to a specific place. Local governments can, however, implement health-relevant policies by developing local evidence for alcohol-related health harms; addressing cumulative impact in licensing policy statements and through other non-legislative approaches such as health and non-health sector partnerships. Innovative local initiatives-for example, minimum unit pricing licensing conditions-can serve as test cases for wider national implementation. By combining the powers available to the many local government sectors involved in alcohol control, alcohol-related health and social harms can be tackled through existing local mechanisms. © The Author 2013. Published by Oxford University Press on behalf of Faculty of Public Health.

  4. Discriminative Relational Topic Models.

    Science.gov (United States)

    Chen, Ning; Zhu, Jun; Xia, Fei; Zhang, Bo

    2015-05-01

    Relational topic models (RTMs) provide a probabilistic generative process to describe both the link structure and document contents for document networks, and they have shown promise on predicting network structures and discovering latent topic representations. However, existing RTMs have limitations in both the restricted model expressiveness and incapability of dealing with imbalanced network data. To expand the scope and improve the inference accuracy of RTMs, this paper presents three extensions: 1) unlike the common link likelihood with a diagonal weight matrix that allows the-same-topic interactions only, we generalize it to use a full weight matrix that captures all pairwise topic interactions and is applicable to asymmetric networks; 2) instead of doing standard Bayesian inference, we perform regularized Bayesian inference (RegBayes) with a regularization parameter to deal with the imbalanced link structure issue in real networks and improve the discriminative ability of learned latent representations; and 3) instead of doing variational approximation with strict mean-field assumptions, we present collapsed Gibbs sampling algorithms for the generalized relational topic models by exploring data augmentation without making restricting assumptions. Under the generic RegBayes framework, we carefully investigate two popular discriminative loss functions, namely, the logistic log-loss and the max-margin hinge loss. Experimental results on several real network datasets demonstrate the significance of these extensions on improving prediction performance.

  5. Planning as a learning process : a strategy for planning land use programmes at local level with special reference to the uplands of Java

    NARCIS (Netherlands)

    Hoek, van den A.

    1992-01-01

    Introduction

    The challenge for land use management in the nineties is to initiate a people- centered development process which creates opportunities for local people to make their own choices about which development strategy to follow. This

  6. Quality Assurance Plan for Data Collection: Characterizing and Quantifying Local and Regional Particulate Matter Emissions from Department of Defense Installations

    National Research Council Canada - National Science Library

    Gillies, J

    2000-01-01

    ...-post regional visibility effects. This document has been assembled to describe the quality assurance plan for data collection for the different components of the proposed research. Quality control (QC...

  7. Topical botulinum toxin.

    Science.gov (United States)

    Collins, Ashley; Nasir, Adnan

    2010-03-01

    Nanotechnology is a rapidly growing discipline that capitalizes on the unique properties of matter engineered on the nanoscale. Vehicles incorporating nanotechnology have led to great strides in drug delivery, allowing for increased active ingredient stability, bioavailability, and site-specific targeting. Botulinum toxin has historically been used for the correction of neurological and neuromuscular disorders, such as torticollis, blepharospasm, and strabismus. Recent dermatological indications have been for the management of axillary hyperhydrosis and facial rhytides. Traditional methods of botulinum toxin delivery have been needle-based. These have been associated with increased pain and cost. Newer methods of botulinum toxin formulation have yielded topical preparations that are bioactive in small pilot clinical studies. While there are some risks associated with topical delivery, the refinement and standardization of delivery systems and techniques for the topical administration of botulinum toxin using nanotechnology is anticipated in the near future.

  8. Urban church forests for local temperature regulation: Implications the role of managing and incorporating urban green space in urban planning

    Directory of Open Access Journals (Sweden)

    Tulu Tolla TURA

    2016-11-01

    Full Text Available The global surface temperature shows an increment of 0.50.1C per decade and 1.050.3C per century from 1880-2014 with greater increases in cities than non-urban areas. Global communities are shifting towards urbanization due to various factors. Urbanization has caused lack of stable condition for dwellers due to environmental and anthropogenic factors such as land cover changes. Urban temperature rising is the main factors hindering urban dwellers at global level due to insufficient green areas. Social institutions are playing important role in urban greening and urban climate regulation. Ethiopian Orthodox Tewahido Church has long history in indigenous trees biodiversity conservation that plays largely greening role in urban and rural parts of the country. However, there is a research gap in Ethiopia regarding the role of urban green area in the church yards in regulating urban temperature and microclimate change. Therefore, the study evaluated the role of church managed forests in Addis Ababa in regulating surface temperature. Surface temperature inside four church forests at a buffer radius of 0–50 m, 50–100 m, 100–200 m and 200–500 m estimated using Landsat image thermal band 6 of 1986, 2000 and 2010 and ground measurement by ambient thermometer at 10:00 am, 12:30 am and 3:00 pm local time. The ground measurement was done in order to validate satellite image analysis. Plant species diversity, DBH, H, HC, BH and BA was measured. There were 1167 trees in the four studied churches. The mean temperatures of the studied sites were 22.50.1, 23.250.2, 240.6, 24.61.1 and 25.52.2C on site,0–50 m, 50–100 m, 100–200m and 200–500 m respectively for 1986 images; 23.20.5, 23.31.0, 24.32.1, 24.82.2 and 25.51.8C on site, 0-50 m, 50–100 m, 100–200 m and 200–500 m respectively for 2000 images and 23.20.3, 23.270.2, 23.71.6, 241.4 and 24.71.3C on site, 0–50 m, 50–100 m

  9. Planning Review: Developments and Planning Issues of Land Use Control in Suburban Areas by Local Government’s Ordinances in Japan

    OpenAIRE

    Mashima, Toshimitsu; Kawakami, Mitsuhiko

    2014-01-01

    This study aims to clarify how changes in the legal system combined with changing social, economic, and environmental pressures have affected approaches taken for land use control. Our emphasis is on how historical transitions in the legal system, particularly in the use of local government ordinances (Development Permission Ordinances and voluntary ordinances concerning land use management) have contributed to land use control in suburban areas. Our results show that because of the revision ...

  10. PRESERVATION OR DEGRADATION OF LOCAL CULTURAL ASSETS IN CENTRAL TOKYO – THE CASE OF THE PLANS TO RELOCATE THE TSUKIJI FISH MARKET

    Directory of Open Access Journals (Sweden)

    Matjaz Ursic

    2013-01-01

    Full Text Available Most cultural-led redevelopment projects in today’s global cities are devised with the clear objective of stimulating their economic growth. Redevelopment schemes usually aim to develop consumption services and urban settings to make the city more attractive for investors. In many cases, redevelopment has led to a diminishment in diversity of local cultural spaces in the inner-city areas. Historically and socially important services and institutions like Tokyo’s Tsukiji Fish Market tend to be relocated and replaced by less traditional and culturally less attractive spaces. This short-term strategy cannot really succeed in preserving or integrating local cultures, which may in the long run help Tokyo to become distinctively different from other global competing cities and to benefit from these advantages. The article analyses the plans to renovate or redevelop specific local consumption spaces in Tokyo, and explores what mechanisms and strategies are being used by the involved actors to accomplish their goals.

  11. Health Topic XML File Description

    Science.gov (United States)

    ... this page: https://medlineplus.gov/xmldescription.html Health Topic XML File Description: MedlinePlus To use the sharing ... information categories assigned. Example of a Full Health Topic Record A record for a MedlinePlus health topic ...

  12. [Diffusion of clinical governance among the Italian Local Health Units (LHUs). Analysis of the Health Surveys, the Firm Acts and the Health Plans].

    Science.gov (United States)

    de Belvis, A G; Biasco, A; Pelone, F; Romaniello, A; De Micco, F; Volpe, M; Ricciardi, W

    2009-01-01

    The objective of our research is to report on the diffusion of Clinical Governance, as introduced with the National Health Plan 2006-2008, by analysing the planning instruments set up by each Region (Regional Health Plans and Emergency Plans in regions with budget deficit), the organizational frameworks (Atti Aziendali, firm acts), and the surveys on performance and quality of healthcare among the Italian Local Health Units (Health Surveys). Our research was realized on September-December 2007 and consisted of the collection of all retrieved documents available on the web and on the online public access catalog (OPAC SBN) of the National Library Service. Futhermore, each document has been classified and analysed according to Chambers' Clinical Governance definition. A descriptive statistical and inferential analysis by applying the Chi-2 Test was performed to test the correlation between the diffusion of such a classified documents and the geographical partition of each LHU. Our results show a scarce diffusion of Firm acts (43%) and Health Surveys (24.9% of the total). Any remind to Clinical Governance instruments and methods inside each document resulted even poorer among both the organizational and performance surveys and the regional health planning frameworks, respectively.

  13. Topics in quantum theory

    International Nuclear Information System (INIS)

    Yuille, A.L.

    1980-11-01

    Topics in the Yang-Mills theories of strong interactions and the quantum theories of gravity are examined, using the path integral approach, including; Yang-Mills instantons in curved spacetimes, Israel-Wilson metrics, Kaehler spacetimes, instantons and anti-instantons. (U.K.)

  14. Salicylic Acid Topical

    Science.gov (United States)

    ... the package label for more information.Apply a small amount of the salicylic acid product to one or two small areas you want to treat for 3 days ... know that children and teenagers who have chicken pox or the flu should not use topical salicylic ...

  15. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

  16. Selected topics in magnetism

    CERN Document Server

    Gupta, L C

    1993-01-01

    Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

  17. Nuclear safety - Topical issues

    International Nuclear Information System (INIS)

    1995-01-01

    The following topical issues related to nuclear safety are discussed: steam generators; maintenance strategies; control rod drive nozzle cracks; core shrouds cracks; sump strainer blockage; fire protection; computer software important for safety; safety during shutdown; operational safety experience; external hazards and other site related issues. 5 figs, 5 tabs

  18. Differential Topic Models.

    Science.gov (United States)

    Chen, Changyou; Buntine, Wray; Ding, Nan; Xie, Lexing; Du, Lan

    2015-02-01

    In applications we may want to compare different document collections: they could have shared content but also different and unique aspects in particular collections. This task has been called comparative text mining or cross-collection modeling. We present a differential topic model for this application that models both topic differences and similarities. For this we use hierarchical Bayesian nonparametric models. Moreover, we found it was important to properly model power-law phenomena in topic-word distributions and thus we used the full Pitman-Yor process rather than just a Dirichlet process. Furthermore, we propose the transformed Pitman-Yor process (TPYP) to incorporate prior knowledge such as vocabulary variations in different collections into the model. To deal with the non-conjugate issue between model prior and likelihood in the TPYP, we thus propose an efficient sampling algorithm using a data augmentation technique based on the multinomial theorem. Experimental results show the model discovers interesting aspects of different collections. We also show the proposed MCMC based algorithm achieves a dramatically reduced test perplexity compared to some existing topic models. Finally, we show our model outperforms the state-of-the-art for document classification/ideology prediction on a number of text collections.

  19. 44 CFR 350.5 - Criteria for review and approval of State and local radiological emergency plans and preparedness.

    Science.gov (United States)

    2010-10-01

    ... completeness.) (3) Arrangements for requesting and effectively using assistance resources have been made... and what their initial actions should be in an emergency (e.g., listening to a local broadcast station...

  20. Epistemic Planning

    DEFF Research Database (Denmark)

    Baral, Chitta; Bolander, Thomas; van Ditmarsch, Hans

    The seminar Epistemic Planning brought together the research communities of Dynamic Epistemic Logic, Knowledge Representation and Reasoning, and Automated Planning to address fundamental problems on the topic of epistemic planning. In the context of this seminar, dynamic epistemic logic...... investigates the formal semantics of communication and communicative actions, knowledge representation and reasoning focuses on theories of action and change, and automated planning investigates computational techniques and tools to generate plans. The original goals of the seminar were to develop benchmarks...... for epistemic planning, to explore the relationship between knowledge and belief in multi-agent epistemic planning, to develop models of agency and capability in epistemic planning and to explore action types and their representations (these originally separate goals were merged during the seminar), and finally...

  1. 68Ga-PSMA-PET/CT imaging of localized primary prostate cancer patients for intensity modulated radiation therapy treatment planning with integrated boost.

    Science.gov (United States)

    Thomas, Lena; Kantz, Steffi; Hung, Arthur; Monaco, Debra; Gaertner, Florian C; Essler, Markus; Strunk, Holger; Laub, Wolfram; Bundschuh, Ralph A

    2018-07-01

    The purpose of our study was to show the feasibility and potential benefits of using 68 Ga-PSMA-PET/CT imaging for radiation therapy treatment planning of patients with primary prostate cancer using either integrated boost on the PET-positive volume or localized treatment of the PET-positive volume. The potential gain of such an approach, the improvement of tumor control, and reduction of the dose to organs-at-risk at the same time was analyzed using the QUANTEC biological model. Twenty-one prostate cancer patients (70 years average) without previous local therapy received 68 Ga-PSMA-PET/CT imaging. Organs-at-risk and standard prostate target volumes were manually defined on the obtained datasets. A PET active volume (PTV_PET) was segmented with a 40% of the maximum activity uptake in the lesion as threshold followed by manual adaption. Five different treatment plan variations were calculated for each patient. Analysis of derived treatment plans was done according to QUANTEC with in-house developed software. Tumor control probability (TCP) and normal tissue complication probability (NTCP) was calculated for all plan variations. Comparing the conventional plans to the plans with integrated boost and plans just treating the PET-positive tumor volume, we found that TCP increased to (95.2 ± 0.5%) for an integrated boost with 75.6 Gy, (98.1 ± 0.3%) for an integrated boost with 80 Gy, (94.7 ± 0.8%) for treatment of PET-positive volume with 75 Gy, and to (99.4 ± 0.1%) for treating PET-positive volume with 95 Gy (all p PET/CT image information allows for more individualized prostate treatment planning. TCP values of identified active tumor volumes were increased, while rectum and bladder NTCP values either remained the same or were even lower. However, further studies need to clarify the clinical benefit for the patients applying these techniques.

  2. Topics and topic prominence in two sign languages

    NARCIS (Netherlands)

    Kimmelman, V.

    2015-01-01

    In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and

  3. Examination of the Locus of Positional Effects on Children's Production of Plural -"s": Considerations from Local and Global Speech Planning

    Science.gov (United States)

    Theodore, Rachel M.; Demuth, Katherine; Shattuck-Hufnagel, Stefanie

    2015-01-01

    Purpose: Prosodic and articulatory factors influence children's production of inflectional morphemes. For example, plural -"s" is produced more reliably in utterance-final compared to utterance-medial position (i.e., the positional effect), which has been attributed to the increased planning time in utterance-final position. In previous…

  4. Expose Mechanical Engineering Students to Biomechanics Topics

    Science.gov (United States)

    Shen, Hui

    2011-01-01

    To adapt the focus of engineering education to emerging new industries and technologies nationwide and in the local area, a biomechanics module has been developed and incorporated into a mechanical engineering technical elective course to expose mechanical engineering students at ONU (Ohio Northern University) to the biomedical engineering topics.…

  5. Topical Therapy of Acute Pharyngitis in Children

    Directory of Open Access Journals (Sweden)

    Yu.K. Bolbot

    2015-02-01

    Full Text Available The paper discusses the methods of topical antiinflammatory therapy for acute pharyngitis in children. The analysis of the complex of mechanisms (antiinflammatory, local analgesic ones of Tantum Verde® action and method of its application are provided.

  6. Topics in industrial mathematics

    International Nuclear Information System (INIS)

    Vatsya, S.R.

    1992-01-01

    Mathematical methods are widely used to solve practical problems arising in modern industry. This article outlines some of the topics relevant to AECL programmes. This covers the applications of transmission and neutron transport tomography to determine density distributions in rocks and two phase flow situations. Another example covered is the use of variational methods to solve the problems of aerosol migration and control theory. (author). 7 refs

  7. Relativity theory - topical

    International Nuclear Information System (INIS)

    Schmutzer, E.

    1979-01-01

    Issued on the occasion of Albert Einstein's 100th birthday the book deals topically with the special and general relativity theory. The latest experiments to confirm the relativity theory are described and the historical development of the theory is presented in detail. Emphasis is given to the disclosure of deep insights into the nature of matter. Of interest to experts in physical and natural sciences and to mathematicians

  8. Entre plan national et initiative locale, l'émergence d'une gouvernance territoriale des risques professionnels ?

    OpenAIRE

    Verdier, Eric; Kornig, Cathel; Mossé, Philippe; Setbon, Michel

    2008-01-01

    A partir du cas des « Réseaux de Veille et de Prévention » des risques professionnels (RVP) mis en place en Provence-Alpes-Côte d'Azur au début des années 2000 dans le cadre du Contrat de Plan Etat-Région 2000-2006, cette recherche s'est efforcé de comprendre comment s'organisait et innovait l'action publique en matière de prévention des risques professionnels. 1. La difficile marche vers une gouvernance territoriale des risques du travail Reprenant les RVP et adopté dès 2005, le Plan régiona...

  9. Locally challenging osteo- and chondrogenic tumors of the axial skeleton: results of combined proton and photon radiation therapy using three-dimensional treatment planning

    Energy Technology Data Exchange (ETDEWEB)

    Hug, Eugen B; Fitzek, Markus M; Liebsch, Norbert J; Munzenrider, John E

    1995-02-01

    Purpose: Tumors of the axial skeleton are at high risk for local failure. Total surgical resection is rarely possible. Critical normal tissues limit the efficacy of conventional photon therapy. This study reviews our experience of using combined high dose proton and photon radiation therapy following three-dimensional (3D) treatment planning. Methods and Materials: Between December 1980 and September 1992, 47 patients were treated at the Massachusetts General Hospital and Harvard Cyclotron Laboratory for primary or recurrent chordomas and chondrosarcomas (group 1, 20 patients), osteogenic sarcomas (group 2, 15 patients) and giant cell tumors, osteo- or chondroblastomas (group 3, 12 patients). Radiation treatment was given postoperatively in 23 patients, pre- and postoperatively in 17 patients, and 7 patients received radiation therapy as definitive treatment modality following biopsy only. The proton radiation component was delivered using a 160 MeV proton beam and the photon component using megavoltage photons up to 23 MV energy with 1.8-2.0 Cobalt Gray Equivalent (CGE) per fraction, once a day. Total external beam target dose ranged from 55.3 CGE to 82.0 CGE with mean target doses of 73.9 CGE (group 1), 69.8 CGE (group 2), and 61.8 CGE (group 3). Results: Group 1 (chordoma and chondrosarcoma): Five of 14 patients (36%) with chordoma recurred locally, and 2 out of 5 patients developed distant metastasis, resulting in 1 death from disease. A trend for improved local control was noted for primary vs. recurrent tumors, target doses > 77 CGE and gross total resection. All patients with chondrosarcoma achieved and maintained local control and disease-free status. Five-year actuarial local control and overall survival rates were 53% and 50% for chordomas and 100% and 100% for chondrosarcomas, respectively. Group 2 (osteogenic sarcoma): Three of 15 patients (20%) never achieved local control and died within 6 months of completion of radiation treatment. Only 1 out of 12

  10. Topic Visualization and Survival Analysis

    OpenAIRE

    Wang, Ping Jr

    2017-01-01

    Latent semantic structure in a text collection is called a topic. In this thesis, we aim to visualize topics in the scientific literature and detect active or inactive research areas based on their lifetime. Topics were extracted from over 1 million abstracts from the arXiv.org database using Latent Dirichlet Allocation (LDA). Hellinger distance measures similarity between two topics. Topics are determined to be relevant if their pairwise distances are smaller than the threshold of Hellinger ...

  11. PLANNING PHASE 2 MULTICENTER RANDOMIZED TRIAL OF NEOADJUVANT CHEMO-RADIOTHERAPY FOLLOWED BY D2 GASTRECTOMY AND ADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED GASTRIC CANCER

    Directory of Open Access Journals (Sweden)

    V. Yu. Skoropad

    2016-01-01

    Full Text Available Introduction. The prognosis for surgical treatment of locally advanced gastric cancer remains disappointing. Neoadjuvant chemo-radiation therapy is relatively new and the least researched method of treatment, it is attracting more and more attention, mainly abroad in recent years. The aims of neoadjuvant therapy is the earliest start of systemic therapy, damage of the primary tumor and regional metastases, an increase in the percentage of radical operations, improving treatment outcome. Material and methods. The planning study is a multicenter, randomized clinical phase II trial. Patients of the first (experimental group will be treated as the followes: neoadjuvant chemo-radiotherapy (total tumor dose of 46 Gy in 23 fractions with the concurrent modified CapOX scheme followed by D2 gastrectomy and adjuvant chemotherapy. Patients of the second (control group will be treated with D2 gastrectomy and adjuvant chemotherapy. Adjuvant chemotherapy will be carried out under the following schemes (optional for the researchers: CapOX or FOLFOX. Toxicity evaluation of neoadjuvant chemo-radiotherapy and adjuvant chemotherapy will be conducted with NCI CTC Toxicity Scale Version 3.0. The main objectives of the trial are to assess the safety and immediate effectiveness of neoadjuvant chemo-radiotherapy according to the criteria of the frequency and severity of postoperative complications and mortality, and tumor response. We are planning to include 80 patients with morphologically confirmed gastric cancer сT2–4N1–3, сT3–4N0–3; М0. The proposed trial will be carried out in accordance with the principles of the Helsinki Declaration, it has been approved by local ethic committees of the participated institutions. Results. As a result of this multicenter randomized trial it is planned to show the reproducibility of obtained in MRRC and a number of foreign centers results – that is, the safety and high immediate effectiveness of neoadjuvant chemo

  12. SU-E-J-244: Development and Validation of a Knowledge Based Planning Model for External Beam Radiation Therapy of Locally Advanced Non-Small Cell Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Z; Kennedy, A [Sarah Cannon, Nashville, TN (United States); Larsen, E; Hayes, C; Grow, A [North Florida Cancer Center, Gainesville, FL (United States); Bahamondes, S.; Zheng, Y; Wu, X [JFK Comprehensive Cancer Institute, Lake Worth, FL (United States); Choi, M; Pai, S [Good Samaritan Hospital, Los Gatos, CA (United States); Li, J [Doctors Hospital of Augusta, Augusta, GA (United States); Cranford, K [Trident Medical Center, Charleston, SC (United States)

    2015-06-15

    Purpose: The study aims to develop and validate a knowledge based planning (KBP) model for external beam radiation therapy of locally advanced non-small cell lung cancer (LA-NSCLC). Methods: RapidPlan™ technology was used to develop a lung KBP model. Plans from 65 patients with LA-NSCLC were used to train the model. 25 patients were treated with VMAT, and the other patients were treated with IMRT. Organs-at-risk (OARs) included right lung, left lung, heart, esophagus, and spinal cord. DVH and geometric distribution DVH were extracted from the treated plans. The model was trained using principal component analysis and step-wise multiple regression. Box plot and regression plot tools were used to identify geometric outliers and dosimetry outliers and help fine-tune the model. The validation was performed by (a) comparing predicted DVH boundaries to actual DVHs of 63 patients and (b) using an independent set of treatment planning data. Results: 63 out of 65 plans were included in the final KBP model with PTV volume ranging from 102.5cc to 1450.2cc. Total treatment dose prescription varied from 50Gy to 70Gy based on institutional guidelines. One patient was excluded due to geometric outlier where 2.18cc of spinal cord was included in PTV. The other patient was excluded due to dosimetric outlier where the dose sparing to spinal cord was heavily enforced in the clinical plan. Target volume, OAR volume, OAR overlap volume percentage to target, and OAR out-of-field volume were included in the trained model. Lungs and heart had two principal component scores of GEDVH, whereas spinal cord and esophagus had three in the final model. Predicted DVH band (mean ±1 standard deviation) represented 66.2±3.6% of all DVHs. Conclusion: A KBP model was developed and validated for radiotherapy of LA-NSCLC in a commercial treatment planning system. The clinical implementation may improve the consistency of IMRT/VMAT planning.

  13. Stereotactic body radiation therapy planning with duodenal sparing using volumetric-modulated arc therapy vs intensity-modulated radiation therapy in locally advanced pancreatic cancer: A dosimetric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Rachit; Wild, Aaron T.; Ziegler, Mark A.; Hooker, Ted K.; Dah, Samson D.; Tran, Phuoc T.; Kang, Jun; Smith, Koren; Zeng, Jing [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401N. Broadway, Weinberg Suite 1440, Baltimore, MD 21231 (United States); Pawlik, Timothy M. [Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Tryggestad, Erik [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401N. Broadway, Weinberg Suite 1440, Baltimore, MD 21231 (United States); Ford, Eric [Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA (United States); Herman, Joseph M., E-mail: jherma15@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401N. Broadway, Weinberg Suite 1440, Baltimore, MD 21231 (United States)

    2013-10-01

    Stereotactic body radiation therapy (SBRT) achieves excellent local control for locally advanced pancreatic cancer (LAPC), but may increase late duodenal toxicity. Volumetric-modulated arc therapy (VMAT) delivers intensity-modulated radiation therapy (IMRT) with a rotating gantry rather than multiple fixed beams. This study dosimetrically evaluates the feasibility of implementing duodenal constraints for SBRT using VMAT vs IMRT. Non–duodenal sparing (NS) and duodenal-sparing (DS) VMAT and IMRT plans delivering 25 Gy in 1 fraction were generated for 15 patients with LAPC. DS plans were constrained to duodenal D{sub max} of<30 Gy at any point. VMAT used 1 360° coplanar arc with 4° spacing between control points, whereas IMRT used 9 coplanar beams with fixed gantry positions at 40° angles. Dosimetric parameters for target volumes and organs at risk were compared for DS planning vs NS planning and VMAT vs IMRT using paired-sample Wilcoxon signed rank tests. Both DS VMAT and DS IMRT achieved significantly reduced duodenal D{sub mean}, D{sub max}, D{sub 1cc}, D{sub 4%}, and V{sub 20} {sub Gy} compared with NS plans (all p≤0.002). DS constraints compromised target coverage for IMRT as demonstrated by reduced V{sub 95%} (p = 0.01) and D{sub mean} (p = 0.02), but not for VMAT. DS constraints resulted in increased dose to right kidney, spinal cord, stomach, and liver for VMAT. Direct comparison of DS VMAT and DS IMRT revealed that VMAT was superior in sparing the left kidney (p<0.001) and the spinal cord (p<0.001), whereas IMRT was superior in sparing the stomach (p = 0.05) and the liver (p = 0.003). DS VMAT required 21% fewer monitor units (p<0.001) and delivered treatment 2.4 minutes faster (p<0.001) than DS IMRT. Implementing DS constraints during SBRT planning for LAPC can significantly reduce duodenal point or volumetric dose parameters for both VMAT and IMRT. The primary consequence of implementing DS constraints for VMAT is increased dose to other organs at

  14. Enhancing Survivorship Care Planning for Patients With Localized Prostate Cancer Using a Couple-Focused mHealth Symptom Self-Management Program: Protocol for a Feasibility Study.

    Science.gov (United States)

    Song, Lixin; Dunlap, Kaitlyn L; Tan, Xianming; Chen, Ronald C; Nielsen, Matthew E; Rabenberg, Rebecca L; Asafu-Adjei, Josephine K; Koontz, Bridget F; Birken, Sarah A; Northouse, Laurel L; Mayer, Deborah K

    2018-02-26

    This project explores a new model of care that enhances survivorship care planning and promotes health for men with localized prostate cancer transitioning to posttreatment self-management. Survivorship care planning is important for patients with prostate cancer because of its high incidence rate in the United States, the frequent occurrence of treatment-related side effects, and reduced quality of life (QOL) for both men and their partners. A key component of comprehensive survivorship care planning is survivorship care plans (SCPs), documents that summarize cancer diagnosis, treatment, and plans for follow-up care. However, research concerning the effectiveness of SCPs on patient outcomes or health service use has thus far been inconclusive. SCPs that are tailored to individual patients' needs for information and care may improve effectiveness. This study aims to examine the feasibility of an enhanced survivorship care plan (ESCP) that integrates a symptom self-management mHealth program called Prostate Cancer Education and Resources for Couples (PERC) into the existing standardized SCP. The specific aims are to (1) examine the feasibility of delivering ESCPs and (2) to estimate the magnitude of benefit of ESCPs. We will use a two-group randomized controlled pretest-posttest design and collect data at baseline (T1) and 4 months later (T2) among 50 patients completing initial treatment for localized prostate cancer and their partners. First, we will assess the feasibility of ESCP by recruitment, enrollment, and retention rates; program satisfaction with the ESCP; and perceived ease of use of the ESCP. To achieve the secondary aim, we will compare the ESCP users with the standardized SCP users and assess their primary outcomes of QOL (overall, physical, emotional, and social QOL); secondary outcomes (reduction in negative appraisals and improvement in self-efficacy, social support, and health behaviors to manage symptoms); and number of visits to posttreatment

  15. Topics in field theory

    CERN Document Server

    Karpilovsky, G

    1989-01-01

    This monograph gives a systematic account of certain important topics pertaining to field theory, including the central ideas, basic results and fundamental methods.Avoiding excessive technical detail, the book is intended for the student who has completed the equivalent of a standard first-year graduate algebra course. Thus it is assumed that the reader is familiar with basic ring-theoretic and group-theoretic concepts. A chapter on algebraic preliminaries is included, as well as a fairly large bibliography of works which are either directly relevant to the text or offer supplementary material of interest.

  16. Topics in CP violation

    International Nuclear Information System (INIS)

    Quinn, H.R.

    1993-02-01

    Given the varied backgrounds of the members of this audience this talk will be a grab bag of topics related to the general theme of CP Violation. I do not have time to dwell in detail on any of them. First, for the astronomers and astrophysicists among you, I want to begin by reviewing the experimental status of evidence for CP violation in particle processes. There is only one system where this has been observed, and that is in the decays of neutral K mesons

  17. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...... food-web systems, nephron pressure and flow regulation, pulsatile secretion of hormones, thermostatically controlled radiator systems, post-stall maneuvering of aircrafts, transfer electron devices for microwave generation, economic long waves, human decision making behavior, and pattern formation...... in chemical reaction-diffusion systems....

  18. Topics in CP violation

    Science.gov (United States)

    Quinn, H. R.

    1993-02-01

    Given the varied backgrounds of the members of this audience this talk will be a grab bag of topics related to the general theme of CP Violation. I do not have time to dwell in detail on any of them. First, for the astronomers and astrophysicists among you, I want to begin by reviewing the experimental status of evidence for CP violation in particle processes. There is only one system where this has been observed, and that is in the decays of neutral K mesons.

  19. Topics in Operator Theory

    CERN Document Server

    Ball, Joseph A; Helton, JWilliam; Rodman, Leiba; Spitkovsky, Iiya

    2010-01-01

    This is the first volume of a collection of original and review articles on recent advances and new directions in a multifaceted and interconnected area of mathematics and its applications. It encompasses many topics in theoretical developments in operator theory and its diverse applications in applied mathematics, physics, engineering, and other disciplines. The purpose is to bring in one volume many important original results of cutting edge research as well as authoritative review of recent achievements, challenges, and future directions in the area of operator theory and its applications.

  20. Hot topics: Signal processing in acoustics

    Science.gov (United States)

    Gaumond, Charles F.

    2005-09-01

    Signal processing in acoustics is a multidisciplinary group of people that work in many areas of acoustics. We have chosen two areas that have shown exciting new applications of signal processing to acoustics or have shown exciting and important results from the use of signal processing. In this session, two hot topics are shown: the use of noiselike acoustic fields to determine sound propagation structure and the use of localization to determine animal behaviors. The first topic shows the application of correlation on geo-acoustic fields to determine the Greens function for propagation through the Earth. These results can then be further used to solve geo-acoustic inverse problems. The first topic also shows the application of correlation using oceanic noise fields to determine the Greens function through the ocean. These results also have utility for oceanic inverse problems. The second topic shows exciting results from the detection, localization, and tracking of marine mammals by two different groups. Results from detection and localization of bullfrogs are shown, too. Each of these studies contributed to the knowledge of animal behavior. [Work supported by ONR.

  1. Topics on continua

    CERN Document Server

    Macias, Sergio

    2005-01-01

    Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

  2. IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC: A direct comparison of PET-based treatment planning.

    Science.gov (United States)

    Fleckenstein, Jochen; Kremp, Katharina; Kremp, Stephanie; Palm, Jan; Rübe, Christian

    2016-02-01

    The potential of intensity-modulated radiation therapy (IMRT) as opposed to three-dimensional conformal radiotherapy (3D-CRT) is analyzed for two different concepts of fluorodeoxyglucose positron emission tomography (FDG PET)-based target volume delineation in locally advanced non-small cell lung cancer (LA-NSCLC): involved-field radiotherapy (IF-RT) vs. elective nodal irradiation (ENI). Treatment planning was performed for 41 patients with LA-NSCLC, using four different planning approaches (3D-CRT-IF, 3D-CRT-ENI, IMRT-IF, IMRT-ENI). ENI included a boost irradiation after 50 Gy. For each plan, maximum dose escalation was calculated based on prespecified normal tissue constraints. The maximum prescription dose (PD), tumor control probability (TCP), conformal indices (CI), and normal tissue complication probabilities (NTCP) were analyzed. IMRT resulted in statistically significant higher prescription doses for both target volume concepts as compared with 3D-CRT (ENI: 68.4 vs. 60.9 Gy, p ENI, there was a considerable theoretical increase in TCP (IMRT: 27.3 vs. 17.7 %, p ENI: 12.3 vs. 30.9 % p < 0.0001; IF: 15.9 vs. 24.1 %; p < 0.001). The IMRT technique and IF target volume delineation allow a significant dose escalation and an increase in TCP. IMRT results in an improved sparing of OARs as compared with 3D-CRT at equivalent dose levels.

  3. Changing the Topic. Topic Position in Ancient Greek Word Order

    NARCIS (Netherlands)

    Allan, R.J.

    2014-01-01

    Ancient Greek, topics can be expressed as intra-clausal constituents but they can also precede or follow the main clause as extra-clausal constituents. Together, these various topic expressions constitute a coherent system of complementary pragmatic functions. For a comprehensive account of topic

  4. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  5. Topics in mathematical biology

    CERN Document Server

    Hadeler, Karl Peter

    2017-01-01

    This book analyzes the impact of quiescent phases on biological models. Quiescence arises, for example, when moving individuals stop moving, hunting predators take a rest, infected individuals are isolated, or cells enter the quiescent compartment of the cell cycle. In the first chapter of Topics in Mathematical Biology general principles about coupled and quiescent systems are derived, including results on shrinking periodic orbits and stabilization of oscillations via quiescence. In subsequent chapters classical biological models are presented in detail and challenged by the introduction of quiescence. These models include delay equations, demographic models, age structured models, Lotka-Volterra systems, replicator systems, genetic models, game theory, Nash equilibria, evolutionary stable strategies, ecological models, epidemiological models, random walks and reaction-diffusion models. In each case we find new and interesting results such as stability of fixed points and/or periodic orbits, excitability...

  6. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    Topical Acne Treatments In every pregnancy, a woman starts out with a 3-5% chance of having a baby ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

  7. Symbiosis: Rich, Exciting, Neglected Topic

    Science.gov (United States)

    Rowland, Jane Thomas

    1974-01-01

    Argues that the topic of symbiosis has been greatly neglected and underemphasized in general-biology textbooks. Discusses many types and examples of symbiosis, and provides an extensive bibliography of the literature related to this topic. (JR)

  8. Wastewater planning in Djenné, Mali. A pilot project for the local infiltration of domestic wastewater.

    Science.gov (United States)

    Alderlieste, M C; Langeveld, J G

    2005-01-01

    The city of Djenné (Mali) is famous for its mosque which is the world's largest adobe building. Djenné is considered to be one of the most interesting cities in Western Africa from an architectural point of view. Since 1988, Djenné is listed as a UNESCO World Heritage Site. In the 1990s, a drinking water supply network was provided by foreign development organisations. However, no facilities were provided for the disposal of wastewater, resulting in an increase of waterborne diseases. This paper describes the urban drainage problem in Djenné and discusses the systematic evaluation of possible solutions and the subsequent pilot project for the local infiltration of sullage. The infiltration of sullage proved to be an appropriate technology for solving the urban drainage problem in Djenné.

  9. Risk assessment of topically applied products

    DEFF Research Database (Denmark)

    Søborg, Tue; Basse, Line Hollesen; Halling-Sørensen, Bent

    2007-01-01

    The human risk of harmful substances in semisolid topical dosage forms applied topically to normal skin and broken skin, respectively, was assessed. Bisphenol A diglycidyl ether (BADGE) and three derivatives of BADGE previously quantified in aqueous cream and the UV filters 3-BC and 4-MBC were used...... as model compounds. Tolerable daily intake (TDI) values have been established for BADGE and derivatives. Endocrine disruption was chosen as endpoint for 3-BC and 4-MBC. Skin permeation of the model compounds was investigated in vitro using pig skin membranes. Tape stripping was applied to simulate broken...... parameters for estimating the risk. The immediate human risk of BADGE and derivatives in topical dosage forms was found to be low. However, local treatment of broken skin may lead to higher exposure of BADGE and derivatives compared to application to normal skin. 3-BC permeated skin at higher flux than 4-MBC...

  10. IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC. A direct comparison of PET-based treatment planning

    International Nuclear Information System (INIS)

    Fleckenstein, Jochen; Kremp, Katharina; Kremp, Stephanie; Palm, Jan; Ruebe, Christian

    2016-01-01

    The potential of intensity-modulated radiation therapy (IMRT) as opposed to three-dimensional conformal radiotherapy (3D-CRT) is analyzed for two different concepts of fluorodeoxyglucose positron emission tomography (FDG PET)-based target volume delineation in locally advanced non-small cell lung cancer (LA-NSCLC): involved-field radiotherapy (IF-RT) vs. elective nodal irradiation (ENI). Treatment planning was performed for 41 patients with LA-NSCLC, using four different planning approaches (3D-CRT-IF, 3D-CRT-ENI, IMRT-IF, IMRT-ENI). ENI included a boost irradiation after 50 Gy. For each plan, maximum dose escalation was calculated based on prespecified normal tissue constraints. The maximum prescription dose (PD), tumor control probability (TCP), conformal indices (CI), and normal tissue complication probabilities (NTCP) were analyzed. IMRT resulted in statistically significant higher prescription doses for both target volume concepts as compared with 3D-CRT (ENI: 68.4 vs. 60.9 Gy, p < 0.001; IF: 74.3 vs. 70.1 Gy, p < 0.03). With IMRT-IF, a PD of at least 66 Gy was achieved for 95 % of all plans. For IF as compared with ENI, there was a considerable theoretical increase in TCP (IMRT: 27.3 vs. 17.7 %, p < 0.00001; 3D-CRT: 20.2 vs. 9.9 %, p < 0.00001). The esophageal NTCP showed a particularly good sparing with IMRT vs. 3D-CRT (ENI: 12.3 vs. 30.9 % p < 0.0001; IF: 15.9 vs. 24.1 %; p < 0.001). The IMRT technique and IF target volume delineation allow a significant dose escalation and an increase in TCP. IMRT results in an improved sparing of OARs as compared with 3D-CRT at equivalent dose levels. (orig.) [de

  11. Dosimetric comparison of standard three-dimensional conformal radiotherapy followed by intensity-modulated radiotherapy boost schedule (sequential IMRT plan) with simultaneous integrated boost-IMRT (SIB IMRT) treatment plan in patients with localized carcinoma prostate.

    Science.gov (United States)

    Bansal, A; Kapoor, R; Singh, S K; Kumar, N; Oinam, A S; Sharma, S C

    2012-07-01

    DOSIMETERIC AND RADIOBIOLOGICAL COMPARISON OF TWO RADIATION SCHEDULES IN LOCALIZED CARCINOMA PROSTATE: Standard Three-Dimensional Conformal Radiotherapy (3DCRT) followed by Intensity Modulated Radiotherapy (IMRT) boost (sequential-IMRT) with Simultaneous Integrated Boost IMRT (SIB-IMRT). Thirty patients were enrolled. In all, the target consisted of PTV P + SV (Prostate and seminal vesicles) and PTV LN (lymph nodes) where PTV refers to planning target volume and the critical structures included: bladder, rectum and small bowel. All patients were treated with sequential-IMRT plan, but for dosimetric comparison, SIB-IMRT plan was also created. The prescription dose to PTV P + SV was 74 Gy in both strategies but with different dose per fraction, however, the dose to PTV LN was 50 Gy delivered in 25 fractions over 5 weeks for sequential-IMRT and 54 Gy delivered in 27 fractions over 5.5 weeks for SIB-IMRT. The treatment plans were compared in terms of dose-volume histograms. Also, Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) obtained with the two plans were compared. The volume of rectum receiving 70 Gy or more (V > 70 Gy) was reduced to 18.23% with SIB-IMRT from 22.81% with sequential-IMRT. SIB-IMRT reduced the mean doses to both bladder and rectum by 13% and 17%, respectively, as compared to sequential-IMRT. NTCP of 0.86 ± 0.75% and 0.01 ± 0.02% for the bladder, 5.87 ± 2.58% and 4.31 ± 2.61% for the rectum and 8.83 ± 7.08% and 8.25 ± 7.98% for the bowel was seen with sequential-IMRT and SIB-IMRT plans respectively. For equal PTV coverage, SIB-IMRT markedly reduced doses to critical structures, therefore should be considered as the strategy for dose escalation. SIB-IMRT achieves lesser NTCP than sequential-IMRT.

  12. A dose planning study on applicator guided stereotactic IMRT boost in combination with 3D MRI based brachytherapy in locally advanced cervical cancer

    International Nuclear Information System (INIS)

    Assenholt, Marianne S.; Petersen, Joergen B.; Nielsen, Soeren K.; Lindegaard, Jacob C.; Tanderup, Kari

    2008-01-01

    Purpose. Locally advanced cervical cancer is usually treated with external beam radiotherapy followed by brachytherapy (BT). However, if response or tumour topography is unfavourable it may be difficult to reach a sufficient BT dose. The purpose of this study was to explore whether an applicator guided stereotactic IMRT boost could be combined with brachytherapy to improve dose volume parameters. Material and methods. Dose plans of 6 patients with HR CTV volumes of 31-100cc at the time of BT were analysed. MRI was performed with a combined intracavitary (IC)-interstitial (IS) ring applicator in situ. A radiotherapy schedule consisting of 45Gy (1.8Gyx25) IMRT followed by boost of 28Gy (7Gyx4fx) was modelled. Four different boost techniques were evaluated: IC-BT, IC/IS-BT, IC-BT+IMRT and IMRT. Dose plans were optimised for maximal tumour dose (D90) and coverage (V85Gy) while respecting DVH constraints in organs at risk: D2cc <75Gy in rectum and sigmoid and <90Gy in bladder (EQD2). In combined BT+IMRT dose plans, the IMRT plan was optimised on top of the BT dose distribution. Volumes irradiated to more than 60 Gy EQD2 (V60Gy) were evaluated. Results. Median dose coverage in IC plans was 74% [66-93%]. By using IC/IS or IC-BT+IMRT boost, the median coverage was improved to 95% [78-99%], and to 96% [69-99%] respectively. For IMRT alone, a median coverage of 98% [90-100%] was achieved, but V60Gy volumes were significantly increased by a median factor of 2.0 [1.4-2.3] as compared to IC/IS. It depended on the individual tumour topography whether IC/IS-BT or IC-BT+IMRT boost was the most favourable technique. Conclusion. It is technically possible to create dose plans that combine image guided BT and IMRT. In this study the dose coverage could be significantly increased by adding IS-BT or IMRT boost to the intracavitary dose. Using IMRT alone for boost cannot be advocated since this results in a significant increase of the volume irradiated to 60Gy

  13. Hanford Site Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, C.A.; Curry, R.H.; Hagan, J.W.; Seiler, S.W.; Sommer, D.J. (Westinghouse Hanford Co., Richland, WA (USA)); Yancey, E.F. (Pacific Northwest Lab., Richland, WA (USA))

    1990-01-01

    The Hanford Site Development Plan (Site Development Plan) is intended to guide the short- and long-range development and use of the Hanford Site. All acquisition, development, and permanent facility use at the Hanford Site will conform to the approved plan. The Site Development Plan also serves as the base document for all subsequent studies that involve use of facilities at the Site. This revision is an update of a previous plan. The executive summary presents the highlights of the five major topics covered in the Site Development Plan: general site information, existing conditions, planning analysis, Master Plan, and Five-Year Plan. 56 refs., 67 figs., 31 tabs.

  14. Hanford Site Development Plan

    International Nuclear Information System (INIS)

    Rinne, C.A.; Curry, R.H.; Hagan, J.W.; Seiler, S.W.; Sommer, D.J.; Yancey, E.F.

    1990-01-01

    The Hanford Site Development Plan (Site Development Plan) is intended to guide the short- and long-range development and use of the Hanford Site. All acquisition, development, and permanent facility use at the Hanford Site will conform to the approved plan. The Site Development Plan also serves as the base document for all subsequent studies that involve use of facilities at the Site. This revision is an update of a previous plan. The executive summary presents the highlights of the five major topics covered in the Site Development Plan: general site information, existing conditions, planning analysis, Master Plan, and Five-Year Plan. 56 refs., 67 figs., 31 tabs

  15. Ontario's primary care reforms have transformed the local care landscape, but a plan is needed for ongoing improvement.

    Science.gov (United States)

    Hutchison, Brian; Glazier, Richard

    2013-04-01

    Primary care in Ontario, Canada, has undergone a series of reforms designed to improve access to care, patient and provider satisfaction, care quality, and health system efficiency and sustainability. We highlight key features of the reforms, which included patient enrollment with a primary care provider; funding for interprofessional primary care organizations; and physician reimbursement based on varying blends of fee-for-service, capitation, and pay-for-performance. With nearly 75 percent of Ontario's population now enrolled in these new models, total payments to primary care physicians increased by 32 percent between 2006 and 2010, and the proportion of Ontario primary care physicians who reported overall satisfaction with the practice of medicine rose from 76 percent in 2009 to 84 percent in 2012. However, primary care in Ontario also faces challenges. There is no meaningful performance measurement system that tracks the impact of these innovations, for example. A better system of risk adjustment is also needed in capitated plans so that groups have the incentive to take on high-need patients. Ongoing investment in these models is required despite fiscal constraints. We recommend a clearly articulated policy road map to continue the transformation.

  16. Examination of the Locus of Positional Effects on Children's Production of Plural -s: Considerations From Local and Global Speech Planning.

    Science.gov (United States)

    Theodore, Rachel M; Demuth, Katherine; Shattuck-Hufnagel, Stefanie

    2015-06-01

    Prosodic and articulatory factors influence children's production of inflectional morphemes. For example, plural -s is produced more reliably in utterance-final compared to utterance-medial position (i.e., the positional effect), which has been attributed to the increased planning time in utterance-final position. In previous investigations of plural -s, utterance-medial plurals were followed by a stop consonant (e.g., dogsbark), inducing high articulatory complexity. We examined whether the positional effect would be observed if the utterance-medial context were simplified to a following vowel. An elicited imitation task was used to collect productions of plural nouns from 2-year-old children. Nouns were elicited utterance-medially and utterance-finally, with the medial plural followed by either a stressed or an unstressed vowel. Acoustic analysis was used to identify evidence of morpheme production. The positional effect was absent when the morpheme was followed by a vowel (e.g., dogseat). However, it returned when the vowel-initial word contained 2 syllables (e.g., dogsarrive), suggesting that the increased processing load in the latter condition negated the facilitative effect of the easy articulatory context. Children's productions of grammatical morphemes reflect a rich interaction between emerging levels of linguistic competence, raising considerations for diagnosis and rehabilitation of language disorders.

  17. Magnetic Resonance Imaging Including Magnetic Resonance Cholangiopancreatography for Tumor Localization and Therapy Planning in Malignant Hilar Obstructions

    International Nuclear Information System (INIS)

    Haenninen, E.L.

    2005-01-01

    PURPOSE: To assess image quality and overall accuracy of magnetic resonance imaging (MRI), including two magnetic cholangiopancreatography (MRCP) techniques, for the diagnostics and preoperative work-up of malignant hilar obstructions. MATERIAL AND METHODS: Thirty-one patients with malignant hilar obstructions (hilar cholangiocarcinoma, n=30; hepatocellular carcinoma, n=1) received MRCP by two techniques (single-shot thick-slab and multisection thin-slice MRCP) and unenhanced and contrast material-enhanced MRI. MR assessment included the evaluation of image quality and visualization of bile ducts (5-point scale), and the classification of tumor status. MR results were subsequently correlated with the results from surgery and pathology. RESULTS: The maximum intensity projections of multisection thin-slice MRCP had significantly more artifacts compared to MRCP in the single-shot thick-slab technique, and overall image quality of single-shot thick-slab MRCP was rated significantly superior compared to multisection thin-slice MRCP (4.4 ± 0.7 and 4.1 ± 0.9, respectively). Moreover, ductal visualization of different parts of the biliary system was rated superior with single-shot thick-slab MRCP. In contrast, the original data from multisection thin slice MRCP facilitated visualization of periductal lesions and adjacent structures. Overall MR accuracy for the assessment of tumor status, periductal infiltration, and lymph node metastases was 90%, 87%, and 66%, respectively. CONCLUSION: For evaluation of malignant hilar obstructions, MRCP by the single-shot thick-slab technique had superior image quality and fewer artifacts; in contrast, besides sole biliary visualization, multisection MRCP depicted complementary adjacent parenchymal and periductal structures. We therefore recommend MRI, with a combination of both MRCP techniques, for the diagnostic work-up and therapy planning of malignant hilar obstructions

  18. Quantifying the National Significance of Local Areas for Regional Conservation Planning: North Carolina’s Mountain Treasures

    Directory of Open Access Journals (Sweden)

    R. Travis Belote

    2017-05-01

    Full Text Available Conservation scientists recognize that additional protected areas are needed to maintain biological diversity and ecological processes. As regional conservation planners embark on recommending additional areas for protection in formal ecological reserves, it is important to evaluate candidate lands for their role in building a resilient protected areas system of the future. Here, we evaluate North Carolina’s Mountain Treasures with respect to their (1 ecological integrity, (2 role in connecting existing core protected areas, (3 potential to diversify the ecosystem representation of reserves, and (4 role in maintaining hotspots of biologically-rich areas that are not well protected. Mountain Treasures represent a citizen inventory of roadless areas and serve as candidates for elevated levels of conservation protection on U.S. federal lands. We compared Mountain Treasures to other candidate lands throughout the country to evaluate their potential national significance. While the Mountain Treasures tended to be more impacted by human modifications than other roadless areas, they are as important as other roadless areas with respect to their role in connecting existing protected areas and diversifying representation of ecosystems in conservation reserves. However, Mountain Treasures tended to have a much higher biodiversity priority index than other roadless areas leading to an overall higher composite score compared to other roadless areas. Our analysis serves as an example of how using broad-scale datasets can help conservation planners assess the national significance of local areas.

  19. The energy intensity target in China's 11th Five-Year Plan period-Local implementation and achievements in Shanxi Province

    International Nuclear Information System (INIS)

    Zhang Daisheng; Aunan, Kristin; Martin Seip, Hans; Vennemo, Haakon

    2011-01-01

    Facing the mounting pressure on energy security and increasing environmental concerns about air pollution and climate change, the Chinese government set a mandatory goal of 20% reduction of energy intensity in its 11th Five-Year Plan period (FYP, 2006-2010). In this paper we use Shanxi province to illustrate how policies and measures are implemented in practice at a provincial level as a response to the National FYP issued by the central government. Local policies are described and their effects are analyzed. We compare reported energy saving achievements with our own estimates and conclude that the achievements in Shanxi probably have been substantial since the start of the 11th FYP period. The most important measures taken by provincial and local governments seem to be in the secondary sector, such as Top-200/Top-1000 program and phasing out outdated technologies. However, Shanxi has still a long way to go to achieve satisfactory energy use. Further improvement of energy intensity will require continuing efforts. Although many measures are necessary, improving the energy efficiency in heavy industries and reducing the dependence on these industries should be particularly effective. - Highlights: → We use Shanxi province to illustrate how local policies respond to the National FYP. → Energy saving in Shanxi has been substantial since the start of the 11th FYP. → Assumptions about baseline energy use strongly affects energy saving estimates. → The most important measures taken by local governments are in the secondary sector. → Further improvement of energy intensity will require efforts especially in heavy industries.

  20. Main technical topics in 1999

    International Nuclear Information System (INIS)

    2000-01-01

    This Safety Authority annual report strives to present current organizational provisions and future trends in nuclear safety supervision in France and to describe the most outstanding occurrences during the past year. A first part presents nine documents concerning the main topics of 1999: aging of nuclear installations, the Offsite Emergency Plans (PPI), the impact of nuclear activities on man and the environment, the criticality hazards, EDF in 1999, the EPR project, the Andra in 1999, the transport incidents, the nuclear safety in eastern Europe. The second part presents the missions and actions of the Nuclear Installations Safety in the domains of the liabilities, the organization of the nuclear safety control, the regulations of the INB, the public information, the international relations, the crisis management, the radioactive materials transportation, the radioactive wastes. The equipment, the radiation protection and the exploitation of the pressurized water reactors are also treated just as the experimental reactors, the fuel cycle installations and the the nuclear installations dismantling. (A.L.B.)

  1. Topics in statistical mechanics

    International Nuclear Information System (INIS)

    Elser, V.

    1984-05-01

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references

  2. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  3. Topics in broken supersymmetry

    International Nuclear Information System (INIS)

    Lee, I.H.

    1984-01-01

    Studies on two topics in the framework of broken supersymmetry are presented. Chapter I is a brief introduction in which the motivation and the background of this work are discussed. In Chapter II, the author studies the decay K + → π + γγ in models with spontaneous supersymmetry breaking and find that it is generally suppressed relative to the decay K + → π + anti nu nu of the conventional model, except possibly for a class of models where the scalar quark masses are generated by radiative corrections from a much larger supersymmetry breaking scale. For a small range of scalar quark and photino mass parameters, the cascade decay process K + → π + π 0 → π + γγ will become dominant over the anti nu nu mode. The author also comments on the possibility of probing the neutrino mass through the K + → π + π 0 → π + anti nu nu cascade decay. Chapter III is concerned with the implications of explicit lepton number violating soft operators in a general low energy effective theory with softly broken supersymmetry

  4. Topics in supersymmetric theories

    International Nuclear Information System (INIS)

    Nemeschansky, D.D.

    1984-01-01

    This thesis discusses four different topics in supersymmetric theories. In the first part models in which supersymmetry is broken by the Fayet-Iliopoulos mechanism are considered. The possibility that scalar quark and lepton masses might arise radiatively in such theories is explored. In the second part supersymmetric grand unified models with a sliding singlet are considered. The author reviews the argument that the sliding singlet does not work in models with large supersymmetry breaking. Then he considers the possibility of using a sliding singlet with low energy supersymmetry breaking. The third part of the thesis deals with the entropy problem of supersymmetric theories. Most supersymmetric models possess a decoupled particle with mass of order 100 GeV which is copiously produced in the early universe and whose decay produces huge amounts of entropy. The author shows how this problem can be avoided in theories in which the hidden sector contains several light fields. In the fourth part effective Lagrangians for supersymmetric theories are studied. The anomalous pion interaction for supersymmetric theories is written down. General properties of this term are studied both on compact and non-compact manifolds

  5. Topics in field theory

    International Nuclear Information System (INIS)

    Velasco, E.S.

    1986-01-01

    This dissertation deals with several topics of field theory. Chapter I is a brief outline of the work presented in the next chapters. In chapter II, the Gauss-Bonnet-Chern theorem for manifolds with boundary is computed using the path integral representation of the Witten index for supersymmetric quantum mechanical systems. In chapter III the action of N = 2 (Poincare) supergravity is obtained in terms of N = 1 superfields. In chapter IV, N = 2 supergravity coupled to the (abelian) vector multiplet is projected into N - 1 superspace. There, the resulting set of constraints is solved in terms of unconstrained prepotential and the action in terms of N = 1 superfields is constructed. In chapter V the set of constraints for N = 2 conformal supergravity is projected into N = 1 superspace and solved in terms of N = 1 conformal supergravity fields a d matter prepotentials. In chapter VI the role of magnetic monopoles in the phase structure of the change one fixed length abelian Higgs model ins the latticer is investigated using analytic and numerical methods. The technique of monopole suppression is used to determine the phase transition lines that are monopole driven. Finally in chapter VII, the role of the charge of the Higgs field in the abelian Higgs model in the lattice is investigated

  6. Topics in inflationary cosmology

    International Nuclear Information System (INIS)

    Kahn, R.N.

    1985-01-01

    This thesis examines several topics in the theory of inflationary cosmology. It first proves the existence of Hawking Radiation during the slow-rolling period of a new inflationary universe. It then derives and somewhat extends Bardeen's gauge invariant formalism for calculating the growth of linear gravitational perturbations in a Friedmann-Robertson-Walker cosmological background. This formalism is then applied, first to several new inflationary universe models all of which show a Zel'dovich spectrum of fluctuations, but with amplitude sigma(100 4 ) above observational limits. The general formalism is next applied to models that exhibit primordial inflation. Fluctuations in these models also exhibit a Zel'dovich spectrum here with an acceptable amplitude. Finally the thesis presents the results of new, numerical calculations. A classical, (2 + 1) dimensional computer model is developed that includes a Higgs field (which drives inflation) along with enough auxiliary fields to generate dynamically not only a thermal bath, but also the fluctuations that naturally accompany that bath. The thesis ends with a discussion of future prospects

  7. Grand unification and gravity - selected topics

    International Nuclear Information System (INIS)

    Zee, A.

    1981-09-01

    The material given here was presented in lectures delivered at the 4th Kyoto Summer Institute on Grand Unification and Related Topics. It consists of six sections. The sections are: the family problem, fermion mass hierarchy, maximal local symmetry, operator analysis of new physics, dynamically generated gravity, and Kaluza theory and grand unification. The last section contains a (hopefully) pedagogical introduction to Kaluza theory. For pedagogical completeness, several appendices reviewing some elementary notions of differential geometry have been added

  8. Magnetic resonance imaging in the radiation treatment planning of localized prostate cancer using intra-prostatic fiducial markers for computed tomography co-registration

    International Nuclear Information System (INIS)

    Parker, C.C.; Damyanovich, A.; Haycocks, T.; Haider, M.; Bayley, A.; Catton, C.N.

    2003-01-01

    Purpose: To assess the feasibility, and potential implications, of using intra-prostatic fiducial markers, rather than bony landmarks, for the co-registration of computed tomography (CT) and magnetic resonance (MR) images in the radiation treatment planning of localized prostate cancer. Methods: All men treated with conformal therapy for localized prostate cancer underwent routine pre-treatment insertion of prostatic fiducial markers to assist with gross target volume (GTV) delineation and to identify prostate positioning during therapy. Six of these men were selected for investigation. Phantom MRI measurements were obtained to quantify image distortion, to determine the most suitable gold alloy marker composition, and to identify the spin-echo sequences that optimized both marker identification and the contrast between the prostate and the surrounding tissues. The GTV for each patient was contoured independently by three radiation oncologists on axial planning CT slices, and on axial MRI slices fused to the CT slices by matching the implanted fiducial markers. From each set of contours the scan common volume (SCV), and the scan encompassing volume (SEV), were obtained. The ratio SEV/SCV for a given scan is a measure of inter-observer variation in contouring. For each of the 18 patient-observer combinations the observer common volume (OCV) and the observer encompassing volume (OEV) was obtained. The ratio OEV/OCV for a given patient-observer combination is a measure of the inter-modality variation in contouring. The distance from the treatment planning isocenter to the prostate contours was measured and the discrepancy between the CT- and the MR-defined contour recorded. The discrepancies between the CT- and MR-defined contours of the posterior prostate were recorded in the sagittal plane at 1-cm intervals above and below the isocenter. Results: Phantom measurements demonstrated trivial image distortion within the required field of view, and an 18K Au/Cu alloy to

  9. Overcoming distance in design and planning methodologies and thinking in order to support climate adaptation strategies and projects to become local

    DEFF Research Database (Denmark)

    Majgaard Krarup, Jonna

    2015-01-01

    sources; the one related to the critique by Hajer and Reijndorp (2001) on the similarities of taste, background, preference etc. among deciding parties in planning and designing urban spaces, and hence designs that users don’t relate to or attach meaning to, i.e. public spaces, which do not function...... as public domains. The other is more specific and refers to a recent PhD study at KADK that cleverly contributes to developing methods of mapping of people in public urban space in Copenhagen by using smartphones in tracking people and identifying the public urban spaces they spend most time in...... in understanding relationships and interdependencies between cities and their local land(-scape) now re-appears. Understandings hereof are essential in developing adequate climate change adaptation measurements. But even so the thinking behind is often situated in and drawing on an urban perspective (Krasny 2014...

  10. High voltage electricity installations a planning perspective

    CERN Document Server

    Jay, Stephen Andrew

    2006-01-01

    The presence of high voltage power lines has provoked widespread concern for many years. High Voltage Electricity Installations presents an in-depth study of policy surrounding the planning of high voltage installations, discussing the manner in which they are percieved by the public, and the associated environmental issues. An analysis of these concerns, along with the geographical, environmental and political influences that shape their expression, is presented. Investigates local planning policy in an area of the energy sector that is of highly topical environmental and public concern Cover

  11. F-18-FDG-PET Confined Radiotherapy of Locally Advanced NSCLC With Concomitant Chemotherapy: Results of the PET-PLAN Pilot Trial

    Energy Technology Data Exchange (ETDEWEB)

    Fleckenstein, Jochen [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Hellwig, Dirk [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Kremp, Stephanie [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Grgic, Aleksandar [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Groeschel, Andreas [Department of Internal Medicine V, Saarland University Medical School, Homburg (Germany); Kirsch, Carl-Martin [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Nestle, Ursula [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Clinic for Radiotherapy, University Hospital, Freiburg (Germany); Ruebe, Christian, E-mail: christian.ruebe@uks.eu [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany)

    2011-11-15

    Purpose: The integration of fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) in the process of radiotherapy (RT) planning of locally advanced non-small-cell lung cancer (NSCLC) may improve diagnostic accuracy and minimize interobserver variability compared with target volume definition solely based on computed tomography. Furthermore, irradiating only FDG-PET-positive findings and omitting elective nodal regions may allow dose escalation by treating smaller volumes. The aim of this prospective pilot trial was to evaluate the therapeutic safety of FDG-PET-based RT treatment planning with an autocontour-derived delineation of the primary tumor. Methods and Materials: Eligible patients had Stages II-III inoperable NSCLC, and simultaneous, platinum-based radiochemotherapy was indicated. FDG-PET and computed tomography acquisitions in RT treatment planning position were coregistered. The clinical target volume (CTV) included the FDG-PET-defined primary tumor, which was autodelineated with a source-to-background algorithm, plus FDG-PET-positive lymph node stations. Limited by dose restrictions for normal tissues, prescribed total doses were in the range of 66.6 to 73.8 Gy. The primary endpoint was the rate of out-of-field isolated nodal recurrences (INR). Results: As per intent to treat, 32 patients received radiochemotherapy. In 15 of these patients, dose escalation above 66.6 Gy was achieved. No Grade 4 toxicities occurred. After a median follow-up time of 27.2 months, the estimated median survival time was 19.3 months. During the observation period, one INR was observed in 23 evaluable patients. Conclusions: FDG-PET-confined target volume definition in radiochemotherapy of NSCLC, based on a contrast-oriented source-to-background algorithm, was associated with a low risk of INR. It might provide improved tumor control because of dose escalation.

  12. Fractional CO2 laser assisted delivery of topical anesthetics: A randomized controlled pilot study

    NARCIS (Netherlands)

    Meesters, Arne A.; Bakker, Myrna M.; de Rie, Menno A.; Wolkerstorfer, Albert

    2016-01-01

    Many dermatological procedures are performed under local anesthesia. Topical anesthesia requires prolonged occlusion and is often insufficient. Infiltration anesthesia is associated with discomfort. Pretreatment with an ablative fractional laser (AFXL) may enhance penetration of topical drugs,

  13. Sexual orientation and suicide ideation, plans, attempts, and medically serious attempts: evidence from local Youth Risk Behavior Surveys, 2001-2009.

    Science.gov (United States)

    Stone, Deborah M; Luo, Feijun; Ouyang, Lijing; Lippy, Caroline; Hertz, Marci F; Crosby, Alex E

    2014-02-01

    We examined the associations between 2 measures of sexual orientation and 4 suicide risk outcomes (SROs) from pooled local Youth Risk Behavior Surveys. We aggregated data from 5 local Youth Risk Behavior Surveys from 2001 to 2009. We defined sexual minority youths (SMYs) by sexual identity (lesbian, gay, bisexual) and sex of sexual contacts (same- or both-sex contacts). Survey logistic regression analyses controlled for a wide range of suicide risk factors and sample design effects. Compared with non-SMYs, all SMYs had increased odds of suicide ideation; bisexual youths, gay males, and both-sex contact females had greater odds of suicide planning; all SMYs, except same-sex contact males, had increased odds of suicide attempts; and lesbians, bisexuals, and both-sex contact youths had increased odds of medically serious attempts. Unsure males had increased odds of suicide ideation compared with heterosexual males. Not having sexual contact was protective of most SROs among females and of medically serious attempts among males. Regardless of sexual orientation measure used, most SMY subgroups had increased odds of all SROs. However, many factors are associated with SROs.

  14. NACS Store Planning Manual.

    Science.gov (United States)

    College Store Journal, 1979

    1979-01-01

    Topics discussed by the NACS Store Planning/Renovation Committees in this updated version of the college store renovation manual include: short- and long-range planning, financial considerations, professional planning assistance, the store's image and business character, location considerations, building requirements, space requirements, fixtures,…

  15. Modeling for sustainable use of biofuels, eolic and solar energy within the scope of the local Brazilian Integrated Planning of Energy Resources: case study of this plan in Aracatuba region, SP, Brazil; Modelagem para o aproveitamento sustentavel dos biocombustiveis, energia eolica e solar dentro do PIR (Planejamento Integrado de Recursos Energeticos) local: estudo de caso do PIR da regiao de Aracatuba, SP, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Jonathas Luiz de Oliveira

    2009-07-01

    It is evaluated the wind power, solar energy resources and biofuels available in Aracatuba through integrated resources planning methodology. which seeks to systematize and qualify the impacts associated with the use of energy by integrating supply and demand and seeking the lowest full-cost recital characteristics of each energy resource in environmental, social, political and technical-economic dimensions . Working with the demand forecast for trend, sustainable energy scenarios, optimistic and sustainable-prime as a PIN for the integration of energy resources over time, and considering the vigilant of Energy-environmental parameters, fetching mapping meeting local demand and export of energy. Thus conclude that the energy resources considered may meet the requirements of demand in all scenarios, but with the possibility of exhaustion in certain scenarios with planning horizon larger than 30 years. (author)

  16. Topics in Bethe Ansatz

    Science.gov (United States)

    Wang, Chunguang

    Integrable quantum spin chains have close connections to integrable quantum field. theories, modern condensed matter physics, string and Yang-Mills theories. Bethe. ansatz is one of the most important approaches for solving quantum integrable spin. chains. At the heart of the algebraic structure of integrable quantum spin chains is. the quantum Yang-Baxter equation and the boundary Yang-Baxter equation. This. thesis focuses on four topics in Bethe ansatz. The Bethe equations for the isotropic periodic spin-1/2 Heisenberg chain with N. sites have solutions containing ±i/2 that are singular: both the corresponding energy and the algebraic Bethe ansatz vector are divergent. Such solutions must be carefully regularized. We consider a regularization involving a parameter that can be. determined using a generalization of the Bethe equations. These generalized Bethe. equations provide a practical way of determining which singular solutions correspond. to eigenvectors of the model. The Bethe equations for the periodic XXX and XXZ spin chains admit singular. solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to bephysical, in which case they correspond to genuine eigenvalues and eigenvectors of. the Hamiltonian. We analyze the ground state of the open spin-1/2 isotropic quantum spin chain. with a non-diagonal boundary term using a recently proposed Bethe ansatz solution. As the coefficient of the non-diagonal boundary term tends to zero, the Bethe roots. split evenly into two sets: those that remain finite, and those that become infinite. We. argue that the former satisfy conventional Bethe equations, while the latter satisfy a. generalization of the Richardson-Gaudin equations. We derive an expression for the. leading correction to the boundary energy in terms of the boundary parameters. We argue that the Hamiltonians for A(2) 2n open quantum spin chains

  17. Topics in string theory

    Science.gov (United States)

    Gorbatov, Elie

    In the first part of the dissertation we study noncommutative field theories at finite temperature. We find evidence for winding states and observe the existence of a transition to a new phase where there is a reduction of the degrees of freedom in the non-planar sector of the theory. We emphasize that such a transition is generic and insensitive to the particulars of the UV definition of the theory. In the second part we investigate some aspects of M-theory compactifications on orbifolds. The heterotic E8 x E 8 string compactified on T4/ ZN has gauge group G x G˜ with massless states in the twisted sector charged under both factors. In the dual M-theory description on T4/ ZN x S1/Z 2 the two groups do not communicate with each other since they reside on the boundary of the eleven dimensional spacetime. This leads to a conundrum for the twisted states of the perturbative heterotic string for there does not seem to be local degrees of freedom which carry charges under both G and G˜. We propose a resolution of this apparent paradox by nonperturbative states in M-theory. In support of our argument we review the consideration of six-dimensional gauge couplings and verify the local anomaly cancellation. In order to understand the dynamical properties of these states we deform the orbifold geometry, find an equivalent string theory background, and brane engineer the low energy six-dimensional field theories. In the process we encounter many exotic and surprising phenomena which are intrinsically M-theoretic and completely invisible to the perturbative observer.

  18. Family planning education.

    Science.gov (United States)

    Hamburg, M V

    1983-02-01

    17 days were spent devoted to the effort of learning about China's educational approach to family planning in the hope of discovering how they are achieving their remarkable success in reducing population growth. As a member of the 1981 New York University/SIECUS Colloquim in China, it was necessary to rely on the translation provided by the excellent guides. Discussions were focused on questions prepared in advance about the topics that concerned the group. These observations, based on a short and limited exposure, cover the following areas: marriage and family planning policies; the family planning program; school programs; adult education; family planning workers; and unique aspects of the program. China has an official position on marriage and family planning that continues to undergo revisions. The new marriage law sets the minimum ages of marriage at 22 for men and 20 for women. Almost everyone marries, and an unmarried person over age 28 is a rarity. The family planning program in China is carried out by an extensive organizational network at national, provincial, and local government levels. Officials termed it a "propaganda campaign." Hospitals, clinics, and factories invariably displayed posters; a popular set of four presents the advantages of the 1 child family as follows: late marriage is best, for it allows more time to work and study; 1 child is best for the health of the mother; one gets free medical care for his/her child if a family has only 1 child; and there is more time to teach 1 child. The state operated television regularly explains the 1 child policy utilizing special films. According to 1 family planning official, "before marriage there is little sex." There are few abortions for unmarried women. Education about sex is for adults, for those persons who are about to be married. There is little if any sex education in schools. Sexual teaching is not generally acceptable, especially in the rural areas. By contrast, in Shanghai the physiology

  19. Spectral Learning for Supervised Topic Models.

    Science.gov (United States)

    Ren, Yong; Wang, Yining; Zhu, Jun

    2018-03-01

    Supervised topic models simultaneously model the latent topic structure of large collections of documents and a response variable associated with each document. Existing inference methods are based on variational approximation or Monte Carlo sampling, which often suffers from the local minimum defect. Spectral methods have been applied to learn unsupervised topic models, such as latent Dirichlet allocation (LDA), with provable guarantees. This paper investigates the possibility of applying spectral methods to recover the parameters of supervised LDA (sLDA). We first present a two-stage spectral method, which recovers the parameters of LDA followed by a power update method to recover the regression model parameters. Then, we further present a single-phase spectral algorithm to jointly recover the topic distribution matrix as well as the regression weights. Our spectral algorithms are provably correct and computationally efficient. We prove a sample complexity bound for each algorithm and subsequently derive a sufficient condition for the identifiability of sLDA. Thorough experiments on synthetic and real-world datasets verify the theory and demonstrate the practical effectiveness of the spectral algorithms. In fact, our results on a large-scale review rating dataset demonstrate that our single-phase spectral algorithm alone gets comparable or even better performance than state-of-the-art methods, while previous work on spectral methods has rarely reported such promising performance.

  20. Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents.

    Science.gov (United States)

    Scheinfeld, Noah

    2014-07-15

    Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n-methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS . Doxepin is available in a 3% or 3.3% concentration (which causes less drowsiness) from compounding pharmacies and can be used in compounded analgesic preparations with positive effect. Topical doxepin is preferred over use of topical amitriptyline because topical doxepin is more effective. Nevertheless, topical amitriptyline increase of the tactile and mechanical nociceptive thresholds and can be used for topical pain control in compound mixture of analgesics . Gabapentin and pregablin can also be used compounded with other agents in topical analgesic preparations with positive topical anesthetic effect. Capsaicin is not useful for topical treatment of the pain of HS. Sometimes compounded of anesthetics medications such as ketamine 10%, bupivacaine 1%, diclofenac 3%, doxepin 3% or 3.3%, and gabapentin 6% can extend the duration of effect so that medication only needs to be used 2 or 3 times a day. Still in my experience the easiest to get and most patient requested agent is topical diclonefac 1% gel.

  1. Topics in nuclear power

    International Nuclear Information System (INIS)

    Budnitz, Robert J.

    2015-01-01

    The 101 nuclear plants operating in the US today are far safer than they were 20-30 years ago. For example, there's been about a 100-fold reduction in the occurrence of 'significant events' since the late 1970s. Although the youngest of currently operating US plants was designed in the 1970s, all have been significantly modified over the years. Key contributors to the safety gains are a vigilant culture, much improved equipment reliability, greatly improved training of operators and maintenance workers, worldwide sharing of experience, and the effective use of probabilistic risk assessment. Several manufacturers have submitted high quality new designs for large reactors to the U.S. Nuclear Regulatory Commission (NRC) for design approval, and several companies are vigorously working on designs for smaller, modular reactors. Although the Fukushima reactor accident in March 2011 in Japan has been an almost unmitigated disaster for the local population due to their being displaced from their homes and workplaces and also due to the land contamination, its 'lessons learned' have been important for the broader nuclear industry, and will surely result in safer nuclear plants worldwide - indeed, have already done so, with more safety improvements to come

  2. Topics in Skyrmion physics

    International Nuclear Information System (INIS)

    1986-01-01

    The first part of the thesis is concerned with the spectrum of fermions interacting with a topological Skyrmion background field. It is shown that, in contradiction to the usual interpretation of a result obtained with the adiabatic approximation, no fermion charge is localized on the Skyrmion through the mechanism of vacuum polarization. This result is obtained by explicitly solving for the continuum spectrum with a simplified Skyrmion profile. However, the Skyrmion can acquire charge if there is spectral flow across zero energy, and an argument is given for why the adiabatic method gives the correct charge under certain conditions. The implications of this understanding of Skyrmion charge for Skyrmion bags are discussed. The second part of the thesis is an investigation into the phenomenology of Skyrmion-like solitons in the standard electroweak model with a large Higgs mass. Estimates of the masses, couplings, and widths of such solitons are derived. The possibility of a resonance analogous to the rho meson in hadron physics is entertained, and the assumption that this resonance is a soliton-antisoliton bound state is used to estimate that its mass is on the order of a TeV. Unitarity arguments are used to get an estimate for the width of this resonance

  3. Topics in nuclear power

    Science.gov (United States)

    Budnitz, Robert J.

    2015-03-01

    The 101 nuclear plants operating in the US today are far safer than they were 20-30 years ago. For example, there's been about a 100-fold reduction in the occurrence of "significant events" since the late 1970s. Although the youngest of currently operating US plants was designed in the 1970s, all have been significantly modified over the years. Key contributors to the safety gains are a vigilant culture, much improved equipment reliability, greatly improved training of operators and maintenance workers, worldwide sharing of experience, and the effective use of probabilistic risk assessment. Several manufacturers have submitted high quality new designs for large reactors to the U.S. Nuclear Regulatory Commission (NRC) for design approval, and several companies are vigorously working on designs for smaller, modular reactors. Although the Fukushima reactor accident in March 2011 in Japan has been an almost unmitigated disaster for the local population due to their being displaced from their homes and workplaces and also due to the land contamination, its "lessons learned" have been important for the broader nuclear industry, and will surely result in safer nuclear plants worldwide - indeed, have already done so, with more safety improvements to come.

  4. Topics in nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Budnitz, Robert J. [Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2015-03-30

    The 101 nuclear plants operating in the US today are far safer than they were 20-30 years ago. For example, there's been about a 100-fold reduction in the occurrence of 'significant events' since the late 1970s. Although the youngest of currently operating US plants was designed in the 1970s, all have been significantly modified over the years. Key contributors to the safety gains are a vigilant culture, much improved equipment reliability, greatly improved training of operators and maintenance workers, worldwide sharing of experience, and the effective use of probabilistic risk assessment. Several manufacturers have submitted high quality new designs for large reactors to the U.S. Nuclear Regulatory Commission (NRC) for design approval, and several companies are vigorously working on designs for smaller, modular reactors. Although the Fukushima reactor accident in March 2011 in Japan has been an almost unmitigated disaster for the local population due to their being displaced from their homes and workplaces and also due to the land contamination, its 'lessons learned' have been important for the broader nuclear industry, and will surely result in safer nuclear plants worldwide - indeed, have already done so, with more safety improvements to come.

  5. Feasibility of MR Imaging/MR Spectroscopy-Planned Focal Partial Salvage Permanent Prostate Implant (PPI) for Localized Recurrence After Initial PPI for Prostate Cancer

    International Nuclear Information System (INIS)

    Hsu, Charles C.; Hsu, Howard; Pickett, Barby; Crehange, Gilles; Hsu, I-Chow Joe; Dea, Ryan; Weinberg, Vivian; Gottschalk, Alexander R.; Kurhanewicz, John; Shinohara, Katsuto; Roach, Mack

    2013-01-01

    Purpose: To assess the feasibility of magnetic resonance imaging (MRI)-planned partial salvage permanent prostate implant (psPPI) among patients with biopsy-proven local recurrence after initial PPI without evidence of distant disease. Methods and Materials: From 2003-2009, 15 patients underwent MRI/magnetic resonance spectroscopy (MRS) planning for salvage brachytherapy (psPPI, I-125 [n=14; 144 Gy]; Pd-103 [n=1; 125 Gy]) without hormone therapy. Full dose was prescribed to areas of recurrence and underdosage, without entire prostate implantation. Limiting urethral and rectal toxicity was prioritized. Follow-up was from salvage date to prostate-specific antigen (PSA) concentration failure (Phoenix criteria = nadir + 2.0; ASTRO = 3 consecutive rises), recurrence, distant metastases, or last follow-up PSA level. Progression-free survival (PFS) was defined as no PSA failure or biopsy-proven recurrence without all-cause mortality. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4.0. Results: At salvage, median age was 68 years, and PSA concentration was 3.5 ng/mL (range, 0.9-5.6 ng/mL). Abnormal MRI/MRS findings were evident in 40% of patients. Biopsy-proven recurrences consisted of a single focus (80%) or 2 foci (20%). At recurrence, Gleason score was 6 (67%) or ≥7 (27%). Median interval between initial and salvage implantation was 69 months (range, 28-132 months). psPPI planning characteristics limited doses to the rectum (mean V100 = 0.5% [0.07 cc]) and urethra (V100 = 12% [0.3 cc]). At median follow-up (23.3 months; range, 8-88 months), treatment failure (n=2) resulted only in localized recurrence; both patients underwent second psPPI with follow-up PSA tests at 12 and 26 months, resulting in 0.6 and 0.7 ng/mL, respectively. American Society for Radiation Oncology PFS rates at 1, 2, and 3 years were 86.7%, 78.4%, and 62.7%, respectively, with 5 patients for whom treatment failed (n=3 with negative transrectal ultrasound

  6. Feasibility of MR Imaging/MR Spectroscopy-Planned Focal Partial Salvage Permanent Prostate Implant (PPI) for Localized Recurrence After Initial PPI for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Charles C., E-mail: hsucc@radonc.ucsf.edu [Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Hsu, Howard [Department of Radiation Oncology, New York University, New York, New York (United States); Pickett, Barby [Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Crehange, Gilles [Department of Radiation Oncology, Dijon University, Dijon (France); Hsu, I-Chow Joe; Dea, Ryan [Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Weinberg, Vivian [Biostatistics and Computational Biology Core, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Gottschalk, Alexander R. [Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Kurhanewicz, John [Department of Radiology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Shinohara, Katsuto [Department of Urology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California (United States)

    2013-02-01

    Purpose: To assess the feasibility of magnetic resonance imaging (MRI)-planned partial salvage permanent prostate implant (psPPI) among patients with biopsy-proven local recurrence after initial PPI without evidence of distant disease. Methods and Materials: From 2003-2009, 15 patients underwent MRI/magnetic resonance spectroscopy (MRS) planning for salvage brachytherapy (psPPI, I-125 [n=14; 144 Gy]; Pd-103 [n=1; 125 Gy]) without hormone therapy. Full dose was prescribed to areas of recurrence and underdosage, without entire prostate implantation. Limiting urethral and rectal toxicity was prioritized. Follow-up was from salvage date to prostate-specific antigen (PSA) concentration failure (Phoenix criteria = nadir + 2.0; ASTRO = 3 consecutive rises), recurrence, distant metastases, or last follow-up PSA level. Progression-free survival (PFS) was defined as no PSA failure or biopsy-proven recurrence without all-cause mortality. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4.0. Results: At salvage, median age was 68 years, and PSA concentration was 3.5 ng/mL (range, 0.9-5.6 ng/mL). Abnormal MRI/MRS findings were evident in 40% of patients. Biopsy-proven recurrences consisted of a single focus (80%) or 2 foci (20%). At recurrence, Gleason score was 6 (67%) or {>=}7 (27%). Median interval between initial and salvage implantation was 69 months (range, 28-132 months). psPPI planning characteristics limited doses to the rectum (mean V100 = 0.5% [0.07 cc]) and urethra (V100 = 12% [0.3 cc]). At median follow-up (23.3 months; range, 8-88 months), treatment failure (n=2) resulted only in localized recurrence; both patients underwent second psPPI with follow-up PSA tests at 12 and 26 months, resulting in 0.6 and 0.7 ng/mL, respectively. American Society for Radiation Oncology PFS rates at 1, 2, and 3 years were 86.7%, 78.4%, and 62.7%, respectively, with 5 patients for whom treatment failed (n=3 with negative transrectal ultrasound

  7. Topics in quantum field theory

    NARCIS (Netherlands)

    Dams, C.J.F.

    2006-01-01

    In this PhD-thesis some topics in quantum field theory are considered. The first chapter gives a background to these topics. The second chapter discusses renormalization. In particular it is shown how loop calculations can be performed when using the axial gauge fixing. Fermion creation and

  8. Web directories as topical context

    NARCIS (Netherlands)

    Kaptein, R.; Kamps, J.; Aly, R.; Hauff, C.; den Hamer, I.; Hiemstra, D.; Huibers, T.; de Jong, F.

    2009-01-01

    In this paper we explore whether the Open Directory (or DMOZ) can be used to classify queries into topical categories on different levels and whether we can use this topical context to improve retrieval performance. We have set up a user study to let test persons explicitly classify queries into

  9. Resources for Topics in Architecture.

    Science.gov (United States)

    Van Noate, Judith, Comp.

    This guide for conducting library research on topics in architecture or on the work of a particular architect presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and series list (PASL). Two topics are researched as examples: the contemporary architect Richard Meier, and…

  10. Drivers Motivating Community Health Improvement Plan Completion by Local Public Health Agencies and Community Partners in the Rocky Mountain Region and Western Plains.

    Science.gov (United States)

    Hill, Anne; Wolf, Holly J; Scallan, Elaine; Case, Jenny; Kellar-Guenther, Yvonne

    There are numerous drivers that motivate completion of community health improvement plans (CHIPs). Some are more obvious and include voluntary public health accreditation, state requirements, federal and state funding, and nonprofit hospital requirements through IRS regulations. Less is known about other drivers, including involvement of diverse partners and belief in best practices, that may motivate CHIP completion. This research investigated the drivers that motivated CHIP completion based on experiences of 51 local public health agencies (LPHAs). An explanatory mixed-methods design, including closed- and open-ended survey questions and key informant interviews, was used to understand the drivers that motivated CHIP completion. Analysis of survey data involved descriptive statistics. Classical content analysis was used for qualitative data to clarify survey findings. The surveys and key informant interviews were conducted in the Rocky Mountain Region and Western Plains among 51 medium and large LPHAs in Colorado, Kansas, Montana, Nebraska, North Dakota, South Dakota, Utah, and Wyoming. More than 50% of respondents were public health directors; the balance of the respondents were division/program directors, accreditation coordinators, and public health planners. CHIP completion. Most LPHAs in the Rocky Mountains and Western Plains have embraced developing and publishing a CHIP, with 80% having completed their plan and another 13% working on it. CHIP completion is motivated by a belief in best practices, with LPHAs and partners seeing the benefit of quality improvement activities linked to the CHIP and the investment of nonprofit hospitals in the process. Completing a CHIP is strengthened through engagement of diverse partners and a well-functioning partnership. The future of CHIP creation depends on LPHAs and partners investing in the CHIP as a best practice, dedicating personnel to CHIP activities, and enhancing leadership skills to contribute to a synergistic

  11. Accuracy of an infrared marker-based patient positioning system (ExacTrac®) for stereotactic body radiotherapy in localizing the planned isocenter using fiducial markers

    Science.gov (United States)

    Montes-Rodríguez, María de los Ángeles; Hernández-Bojórquez, Mariana; Martínez-Gómez, Alma Angélica; Contreras-Pérez, Agustín; Negrete-Hernández, Ingrid Mireya; Hernández-Oviedo, Jorge Omar; Mitsoura, Eleni; Santiago-Concha, Bernardino Gabriel

    2014-11-01

    Stereotactic Body Radiation Therapy (SBRT) requires a controlled immobilization and position monitoring of patient and target. The purpose of this work is to analyze the performance of the imaging system ExacTrac® (ETX) using infrared and fiducial markers. Materials and methods: In order to assure the accuracy of isocenter localization, a Quality Assurance procedure was applied using an infrared marker-based positioning system. Scans were acquired of an inhouse-agar gel and solid water phantom with infrared spheres. In the inner part of the phantom, three reference markers were delineated as reference and one pellet was place internally; which was assigned as the isocenter. The iPlan® RT Dose treatment planning system. Images were exported to the ETX console. Images were acquired with the ETX to check the correctness of the isocenter placement. Adjustments were made in 6D the reference markers were used to fuse the images. Couch shifts were registered. The procedure was repeated for verification purposes. Results: The data recorded of the verifications in translational and rotational movements showed averaged 3D spatial uncertainties of 0.31 ± 0.42 mm respectively 0.82° ± 0.46° in the phantom and the first correction of these uncertainties were of 1.51 ± 1.14 mm respectively and 1.37° ± 0.61°. Conclusions: This study shows a high accuracy and repeatability in positioning the selected isocenter. The ETX-system for verifying the treatment isocenter position has the ability to monitor the tracing position of interest, making it possible to be used for SBRT positioning within uncertainty ≤1mm.

  12. Accuracy of an infrared marker-based patient positioning system (ExacTrac®) for stereotactic body radiotherapy in localizing the planned isocenter using fiducial markers

    Energy Technology Data Exchange (ETDEWEB)

    Montes-Rodríguez, María de los Ángeles, E-mail: angy24538@yahoo.com; Mitsoura, Eleni [Medical Physics Graduate Programme, Universidad Autónoma del Estado de México, Facultad de Medicina, Paseo Tollocan esquina Jesús Carranza Colonia Moderna de la Cruz, C.P. 50180, Toluca, Estado de México (Mexico); Hernández-Bojórquez, Mariana; Martínez-Gómez, Alma Angélica; Contreras-Pérez, Agustín; Negrete-Hernández, Ingrid Mireya; Hernández-Oviedo, Jorge Omar; Santiago-Concha, Bernardino Gabriel [Centro de Cáncer ABC, The American British Cowdray Medical Center I.A.P. (CMABC), Calle Sur 136, no. 116, Colonia las Américas, C.P. 01120, México, D.F. (Mexico)

    2014-11-07

    Stereotactic Body Radiation Therapy (SBRT) requires a controlled immobilization and position monitoring of patient and target. The purpose of this work is to analyze the performance of the imaging system ExacTrac® (ETX) using infrared and fiducial markers. Materials and methods: In order to assure the accuracy of isocenter localization, a Quality Assurance procedure was applied using an infrared marker-based positioning system. Scans were acquired of an inhouse-agar gel and solid water phantom with infrared spheres. In the inner part of the phantom, three reference markers were delineated as reference and one pellet was place internally; which was assigned as the isocenter. The iPlan® RT Dose treatment planning system. Images were exported to the ETX console. Images were acquired with the ETX to check the correctness of the isocenter placement. Adjustments were made in 6D the reference markers were used to fuse the images. Couch shifts were registered. The procedure was repeated for verification purposes. Results: The data recorded of the verifications in translational and rotational movements showed averaged 3D spatial uncertainties of 0.31 ± 0.42 mm respectively 0.82° ± 0.46° in the phantom and the first correction of these uncertainties were of 1.51 ± 1.14 mm respectively and 1.37° ± 0.61°. Conclusions: This study shows a high accuracy and repeatability in positioning the selected isocenter. The ETX-system for verifying the treatment isocenter position has the ability to monitor the tracing position of interest, making it possible to be used for SBRT positioning within uncertainty ≤1mm.

  13. Five-year biochemical outcome and toxicity with transperineal CT-planned permanent I-125 prostate implantation for patients with localized prostate cancer

    International Nuclear Information System (INIS)

    Zelefsky, Michael J.; Hollister, Timothy; Raben, Adam; Matthews, Sheeba; Wallner, Kent E.

    2000-01-01

    Purpose: To report the 5-year prostate-specific antigen (PSA) relapse-free survival outcome and incidence of long-term morbidity for patients with localized prostate cancer treated with CT-planned permanent I-125 prostate implantation using a transperineal technique (TPI). Methods and Materials: Between 1989-1996, 248 patients with clinically localized prostate cancer were treated with TPI. The median age was 65 years (range: 45-80 years). The clinical stage was T1c in 143 patients (58%), Stage T2a in 102 (41%), and T2b in 3 (1%). Thirty patients (12%) had Gleason scores 10 ng/mL and Gleason score >6) were classified as having intermediate and unfavorable risk disease, respectively. PSA relapse was defined according to the American Society of Therapeutic Radiation Oncology Consensus Statement, and toxicity was scored according to the Radiation Therapy Oncology Group morbidity scoring scale. The median follow-up was 48 months (range: 12-126 months). Results: Thirty-eight patients (15%) developed a PSA relapse, and the overall 5-year PSA relapse-free survival (PRFS) rate was 71%. The 5-year PRFS rates for favorable-risk (n = 146), intermediate-risk (n = 85), and unfavorable-risk (n = 17) patients were 88%, 77%, and 38%, respectively (p 10 ng/mL and Gleason score >6 as independent predictors for biochemical relapse after TPI. The 5-year actuarial likelihood of late Grade 2 urinary toxicity was 41%. The 5-year likelihood of urethral stricture development was 10%, and the median time to stricture development was 18 months. One patient (0.4%) in the early phase of this clinical experience developed a Grade 4 urethral complication. The actuarial incidence of late Grade 2 rectal bleeding was 9%. One patient (0.4%) developed a Grade 4 rectal complication. Conclusions: Especially for favorable risk disease, the 5-year biochemical outcome with this approach was excellent and appears to be comparable to other therapeutic interventions. Grade 2 urinary symptoms were common in

  14. Breastfeeding: Planning Ahead

    Medline Plus

    Full Text Available ... Pregnancy Thyroid disease All A-Z health topics Find Help Get breastfeeding help Get health care Get ... with family planning Get help with mental health Find girls' health information Stay Connected Blog Contact us ...

  15. Breastfeeding: Planning Ahead

    Medline Plus

    Full Text Available ... Easy An Interview About Breastfeeding: Lauren Sogor Taking Care of Your Health — and Your Baby's Subscribe ... topics Find Help Get breastfeeding help Get health care Get health insurance Get help with family planning ...

  16. Breastfeeding: Planning Ahead

    Medline Plus

    Full Text Available ... we are What we do Programs and activities Work with us Contact Us Blog Popular topics Vision ... Planning ahead Breastfeeding and baby basics Making breastfeeding work for you Addressing breastfeeding myths Breastfeeding myths in ...

  17. A multidisciplinary protocol for planned skin-preserving delayed breast reconstruction for patients with locally advanced breast cancer requiring postmastectomy radiation therapy: 3-year follow-up.

    Science.gov (United States)

    Kronowitz, Steven J; Lam, Candace; Terefe, Welela; Hunt, Kelly K; Kuerer, Henry M; Valero, Vicente; Lance, Samuel; Robb, Geoffrey L; Feng, Lei; Buchholz, Thomas A

    2011-06-01

    The authors examined the safety of a protocol for planned skin-preserving delayed breast reconstruction after postmastectomy radiotherapy with placement of a tissue expander for patients with locally advanced breast cancer (stages IIB and III). The authors compared 47 patients treated according to the protocol between December 2003 and May 2008 with 47 disease-stage-matched control patients who underwent standard delayed reconstruction after postmastectomy radiotherapy (no skin preservation or tissue expander) during the same period. Protocol-group complication rates were 21 percent for skin-preserving mastectomy and placement of the expander (stage 1), 5 percent for postmastectomy radiotherapy, 25 percent for expander reinflation after radiotherapy, and 24 percent for skin-preserving delayed reconstruction. The complication rate for standard delayed reconstruction was 38 percent. Tissue-expander loss rates were 32 percent overall, 9 percent for stage 1, 5 percent for postmastectomy radiotherapy, and 22 percent for reinflation. Wound-healing complications after reconstruction occurred in 3 percent of protocol-group and 10 percent of control-group patients. The median follow-up time for patients still alive at last follow-up was 40 months (range, 8.5 to 85.3 months). Three-year recurrence-free survival rates were 92 percent (95 percent CI, 83 to 100 percent) and 86 percent (95 percent CI, 76 to 98 percent) for the protocol and control groups, respectively (p = 0.87). In patients with locally advanced breast cancer, skin-preserving mastectomy with a deflated tissue expander on the chest wall during postmastectomy radiotherapy does not increase locoregional recurrence risk and is associated with lower complication rates of definitive reconstruction.

  18. WE-AB-207B-09: Margin Reduction for Planning Target Volume (PTV) in Patients with Localized Prostate Cancer: Impact On Delivered Dose and Quality of Life

    Energy Technology Data Exchange (ETDEWEB)

    Kumarasiri, A; Liu, C; Brown, S; Glide-Hurst, C; Elshaikh, M; Chetty, I; Movsas, B [Henry Ford Health System, Detroit, MI (United States)

    2016-06-15

    Purpose: To estimate the delivered (cumulative) dose to targets and organs at risk for localized prostate cancer patients treated with reduced PTV margins and to evaluate preliminary patient reported quality-of-life (QOL). Methods: Under an IRB-approved protocol, 20 prostate cancer patients (including 11 control patients) were treated with reduced planning margins (5 mm uniform with 4 mm at prostate/rectum interface). Control patients had standard margin (10/6 mm)-based treatments. A parameter-optimized Elastix algorithm along with energy-mass mapping was used to deform and resample dose of the day onto the planning CT for each fraction to estimate the delivered dose over all fractions. QOL data were collected via Expanded Prostate cancer Index Composite (EPIC-26) questionnaires at time points pre-treatment, post-treatment, and at 2, 6, 12, 18 month follow-ups. Standardized QOL scores [range: 0–100] were determined and baseline-corrected by subtracting pre-treatment QOL data. Mean QOL differences between the margin reduced group and control group (QOLmr-QOLcontrol) were calculated for first 18 months. Results: The difference between the cumulative mean dose (Dmean) and the planned mean dose (±SD) for PTV, prostate, bladder, and rectum were −2.2±1.0, 0.3±0.5, −0.7±2.6, and −2.1±1.3 Gy respectively for the margin-reduced group, and −0.8±2.0, 0.9±1.4, - 0.7±3.1 and −1.0±2.4 Gy for the control group. Difference between the two groups was statistically insignificant (p=0.1). Standardized and baseline corrected QOLmr-QOLcontrol for EPIC domains categorized as “Urinary Incontinence”, “Urinary Irritative/Obstructive”, “Bowel”, “Sexual”, and “Hormonal” were 0.6, 12.1, 9.1, 13.3, and −0.9 for the 18 months following radiation therapy (higher values better). Delivered dose to rectum showed a weak correlation to “Bowel” domain (Pearson’s coefficient −0.24, p<0.001), while bladder dose did not correlate to Urinary Incontinence

  19. WE-AB-207B-09: Margin Reduction for Planning Target Volume (PTV) in Patients with Localized Prostate Cancer: Impact On Delivered Dose and Quality of Life

    International Nuclear Information System (INIS)

    Kumarasiri, A; Liu, C; Brown, S; Glide-Hurst, C; Elshaikh, M; Chetty, I; Movsas, B

    2016-01-01

    Purpose: To estimate the delivered (cumulative) dose to targets and organs at risk for localized prostate cancer patients treated with reduced PTV margins and to evaluate preliminary patient reported quality-of-life (QOL). Methods: Under an IRB-approved protocol, 20 prostate cancer patients (including 11 control patients) were treated with reduced planning margins (5 mm uniform with 4 mm at prostate/rectum interface). Control patients had standard margin (10/6 mm)-based treatments. A parameter-optimized Elastix algorithm along with energy-mass mapping was used to deform and resample dose of the day onto the planning CT for each fraction to estimate the delivered dose over all fractions. QOL data were collected via Expanded Prostate cancer Index Composite (EPIC-26) questionnaires at time points pre-treatment, post-treatment, and at 2, 6, 12, 18 month follow-ups. Standardized QOL scores [range: 0–100] were determined and baseline-corrected by subtracting pre-treatment QOL data. Mean QOL differences between the margin reduced group and control group (QOLmr-QOLcontrol) were calculated for first 18 months. Results: The difference between the cumulative mean dose (Dmean) and the planned mean dose (±SD) for PTV, prostate, bladder, and rectum were −2.2±1.0, 0.3±0.5, −0.7±2.6, and −2.1±1.3 Gy respectively for the margin-reduced group, and −0.8±2.0, 0.9±1.4, - 0.7±3.1 and −1.0±2.4 Gy for the control group. Difference between the two groups was statistically insignificant (p=0.1). Standardized and baseline corrected QOLmr-QOLcontrol for EPIC domains categorized as “Urinary Incontinence”, “Urinary Irritative/Obstructive”, “Bowel”, “Sexual”, and “Hormonal” were 0.6, 12.1, 9.1, 13.3, and −0.9 for the 18 months following radiation therapy (higher values better). Delivered dose to rectum showed a weak correlation to “Bowel” domain (Pearson’s coefficient −0.24, p<0.001), while bladder dose did not correlate to Urinary Incontinence

  20. Breastfeeding: Planning Ahead

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    Full Text Available ... Popular Topics Autoimmune diseases Breastfeeding Carpal tunnel syndrome Depression HIV and AIDS Menstruation Polycystic ovary syndrome (PCOS) Pregnancy Thyroid disease All A-Z health topics Find Help Get breastfeeding help Get health care Get health insurance Get help with family planning ...

  1. IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC. A direct comparison of PET-based treatment planning

    Energy Technology Data Exchange (ETDEWEB)

    Fleckenstein, Jochen; Kremp, Katharina; Kremp, Stephanie; Palm, Jan; Ruebe, Christian [Saarland University Medical School, Department of Radiotherapy and Radiation Oncology, Homburg/Saar (Germany)

    2016-02-15

    The potential of intensity-modulated radiation therapy (IMRT) as opposed to three-dimensional conformal radiotherapy (3D-CRT) is analyzed for two different concepts of fluorodeoxyglucose positron emission tomography (FDG PET)-based target volume delineation in locally advanced non-small cell lung cancer (LA-NSCLC): involved-field radiotherapy (IF-RT) vs. elective nodal irradiation (ENI). Treatment planning was performed for 41 patients with LA-NSCLC, using four different planning approaches (3D-CRT-IF, 3D-CRT-ENI, IMRT-IF, IMRT-ENI). ENI included a boost irradiation after 50 Gy. For each plan, maximum dose escalation was calculated based on prespecified normal tissue constraints. The maximum prescription dose (PD), tumor control probability (TCP), conformal indices (CI), and normal tissue complication probabilities (NTCP) were analyzed. IMRT resulted in statistically significant higher prescription doses for both target volume concepts as compared with 3D-CRT (ENI: 68.4 vs. 60.9 Gy, p < 0.001; IF: 74.3 vs. 70.1 Gy, p < 0.03). With IMRT-IF, a PD of at least 66 Gy was achieved for 95 % of all plans. For IF as compared with ENI, there was a considerable theoretical increase in TCP (IMRT: 27.3 vs. 17.7 %, p < 0.00001; 3D-CRT: 20.2 vs. 9.9 %, p < 0.00001). The esophageal NTCP showed a particularly good sparing with IMRT vs. 3D-CRT (ENI: 12.3 vs. 30.9 % p < 0.0001; IF: 15.9 vs. 24.1 %; p < 0.001). The IMRT technique and IF target volume delineation allow a significant dose escalation and an increase in TCP. IMRT results in an improved sparing of OARs as compared with 3D-CRT at equivalent dose levels. (orig.) [German] Das Potenzial der intensitaetsmodulierten Strahlentherapie (IMRT) soll im Rahmen der FDG-PET basierten Bestrahlungsplanung des lokal fortgeschrittenen nichtkleinzelligen Bronchialkarzinoms (LA-NSCLC) fuer 2 Zielvolumenansaetze (Involved-Field-Bestrahlung, IF) sowie elektive Nodalbestrahlung (ENI) geprueft und mit der 3-D-konformalen Strahlentherapie (3-D

  2. Local Estuary Programs

    Science.gov (United States)

    This page provides information about Local Individual Estuary Programs including links to their NEP homepages, social media, Comprehensive Conservation and Management Plans, and state of the bay reports.

  3. Topical tacrolimus for atopic dermatitis.

    Science.gov (United States)

    Cury Martins, Jade; Martins, Ciro; Aoki, Valeria; Gois, Aecio F T; Ishii, Henrique A; da Silva, Edina M K

    2015-07-01

    .98, 1 study, n = 139, low-quality evidence), but the effects were equivocal when evaluating BSA. In the comparison of tacrolimus 0.03% with moderate-to-potent corticosteroids, no difference was found in most of the outcomes measured (including physician's and participant's assessment and also for the secondary outcomes), but in two studies, a marginal benefit favouring the corticosteroid group was found for the EASI and BSA scores.Burning was more frequent in those using calcineurin inhibitors than those using corticosteroid tacrolimus 0.03% (RR 2.48, 95% CI 1.96 to 3.14, 5 studies, 1883 participants, high-quality evidence), but no difference was found for skin infections. Symptoms observed were mild and transient. The comparison between the two calcineurin inhibitors (pimecrolimus and tacrolimus) showed the same overall incidence of adverse events, but with a small difference in the frequency of local effects.Serious adverse events were rare; occurred in both the tacrolimus and corticosteroid groups; and in most cases, were considered to be unrelated to the treatment. No cases of lymphoma were noted in the included studies nor in the non-comparative studies. Cases were only noted in spontaneous reports, cohorts, and case-control studies. Systemic absorption was rarely detectable, only in low levels, and this decreased with time. Exception is made for diseases with severe barrier defects, such as Netherton's syndrome, lamellar ichthyosis, and a few others, with case reports of a higher absorption. We evaluated clinical trials; case reports; and in vivo, in vitro, and animal studies; and didn't find any evidence that topical tacrolimus could cause skin atrophy. Tacrolimus 0.1% was better than low-potency corticosteroids, pimecrolimus 1%, and tacrolimus 0.03%. Results were equivocal when comparing both dose formulations to moderate-to-potent corticosteroids. Tacrolimus 0.03% was superior to mild corticosteroids and pimecrolimus. Both tacrolimus formulations seemed to be

  4. Mental Mechanisms for Topics Identification

    Directory of Open Access Journals (Sweden)

    Louis Massey

    2014-01-01

    Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

  5. Topic Model for Graph Mining.

    Science.gov (United States)

    Xuan, Junyu; Lu, Jie; Zhang, Guangquan; Luo, Xiangfeng

    2015-12-01

    Graph mining has been a popular research area because of its numerous application scenarios. Many unstructured and structured data can be represented as graphs, such as, documents, chemical molecular structures, and images. However, an issue in relation to current research on graphs is that they cannot adequately discover the topics hidden in graph-structured data which can be beneficial for both the unsupervised learning and supervised learning of the graphs. Although topic models have proved to be very successful in discovering latent topics, the standard topic models cannot be directly applied to graph-structured data due to the "bag-of-word" assumption. In this paper, an innovative graph topic model (GTM) is proposed to address this issue, which uses Bernoulli distributions to model the edges between nodes in a graph. It can, therefore, make the edges in a graph contribute to latent topic discovery and further improve the accuracy of the supervised and unsupervised learning of graphs. The experimental results on two different types of graph datasets show that the proposed GTM outperforms the latent Dirichlet allocation on classification by using the unveiled topics of these two models to represent graphs.

  6. Local failure after radical radiotherapy of non-small cell lung cancer in relation to the planning FDG-PET/CT

    DEFF Research Database (Denmark)

    Kandi, M; Hoffmann, L; Sloth Moeller, D

    2018-01-01

    OBJECTIVES: Local recurrence (rec) in lung cancer is associated with poor survival. This study examined whether the pattern of failure is associated with the most PET avid volume in the planning-FDG-PET/CT scan (p-PET/CT). METHODS: 162 consecutive inoperable NSCLC patients (pts) receiving...... 50% of SUVpeak on p-PET/CT and the volume of T-rec was calculated: OF = (SUVp50∩T-rec)/min(SUVp50, T-rec). Similarly for the GTV on the p-CT: OF = (GTV∩T-rec)/min(GTV, T-rec). OF was based on a rigid registration between p-PET/CT and rec-CT with PET guided delineation of T- rec. For lymph nodes (LN...... in these stations; 4R (55%) and 7 (83%). CONCLUSIONS: This study indicates that the most PET active volume on p-PET-CT is a driver for rec at T-site. LN-recurrences predominantly appear in station 2R, 4R, 7 and right hilum. Additional confirmatory studies regarding lymph node mapping and selective lymph node...

  7. Adverse effects after radical external beam radiotherapy of localized prostatic adenocarcinoma using two-dimensional dose-planning and a limited field technique

    International Nuclear Information System (INIS)

    Ljung, G.; Haeggman, M.; Hansson, H.; Holmberg, L.; Nilsson, S.

    1996-01-01

    Adverse effects were assessed after definitive limited field, 2-dimensional CT-planned radiation treatment of localized prostatic adenocarcinoma. In 66 surviving patients, out of a total of 176 treated patients, personal interviews were performed and self-administered questionnaires distributed. The average follow-up was 6.6 years. Adverse effects with regard to bowel function and micturition were investigated, and graded 0-4 with increasing severity and impact on performance status, essentially according to the RTOG toxicity scoring system. Sexual functions were registered on visual analogue scales. The majority of adverse effects were considered minor (grade 1) and did not require any treatment. Late adverse effects on bowel and bladder or urethra that required treatment (grade 2-4) were reported in up to 8% (n=5) of cases respectively. Late bowel side-effects that interfered with life style (grade 3-4) occurred in up to 3% (n=2) of patients; the majority were rectal complications. Corresponding urinary side-effects were registered in up to 6% (n=4) of the patients. Major surgical interventions were not required. Sexual functions were substantially affected in 60% of cases not administered endocrine treatment. Multivariate analyses could not identify patient or treatment risk factors related to complications. (orig.)

  8. Topical steroid-damaged skin

    Directory of Open Access Journals (Sweden)

    Anil Abraham

    2014-01-01

    Full Text Available Topical steroids, commonly used for a wide range of skin disorders, are associated with side effects both systemic and cutaneous. This article aims at bringing awareness among practitioners, about the cutaneous side effects of easily available, over the counter, topical steroids. This makes it important for us as dermatologists to weigh the usefulness of topical steroids versus their side effects, and to make an informed decision regarding their use in each individual based on other factors such as age, site involved and type of skin disorder.

  9. Topics in lightwave transmission systems

    CERN Document Server

    Li, Tingye

    1991-01-01

    Topics in Lightwave Transmission Systems is a second volume of a treatise on optical fiber communications that is devoted to the science, engineering, and application of information transmission via optical fibers. The first volume, published in 1985, dealt exclusively with fiber fabrication. The present volume contains topics that pertain to subsystems and systems. The book contains five chapters and begins with discussions of transmitters and receivers, which are basic to systems now operating in the field. Subsequent chapters cover topics relating to coherent systems: frequency and phase m

  10. Planejamento local: a fala do gerente de Unidade Básica de Saúde Planificación local: la habla de lo gerente de Unidad Básica de Salud Local planning: the speech of Basic Health Care Center manager

    Directory of Open Access Journals (Sweden)

    Márcia Regina Cubas

    2005-06-01

    Full Text Available Entendendo o planejamento como ferramenta de gestão, este artigo oferece através da metodologia do Discurso do Sujeito Coletivo, uma discussão acerca das falas dos Gerentes de Unidades Básicas de Saúde do município de Curitiba - PR sobre aspectos do planejamento local. Tem como finalidade possibilitar aos gestores locais uma reflexão sobre seus estilos, práticas e experiências, assim como colaborar com equipes dirigentes de nível central na construção de seus processos de planejamento de forma ascendente, participativa, comunicativa e estratégica. São apresentadas considerações dos Discursos construídos a partir das idéias centrais: metodologia do planejamento; intersetorialidade; base territorial; participação da equipe e da comunidade; capacitação, autonomia e perfil particular do gerente local; agenda do gestor e a cultura institucional.Entendiendo que el planificación es herramienta de gestión, el presente artículo ofrece a través de la metodología del Discurso del Sujeto Colectivo, una discusión sobre las hablas de los Gerentes de Unidades Básicas de Salud del municipio de Curitiba PR sobre aspectos referentes al planificación local. Tiene por finalidad posibilitar a los gestores locales una reflexión sobre sus estilos, prácticas y experiencias, como también colaborar con equipos dirigentes de nivel central en la construcción de sus procesos de planificación de forma ascendiente, participativa, comunicativa y estratégica. Se presentan consideraciones de los Discursos construidos a partir de las ideas centrales: metodología del planeamiento; intersectorialidad; base territorial; participación del equipo y de la comunidad; capacitación, autonomía y perfil particular del gerente local; agenda del gestor y la cultura institucional.As planning is understood as a management tool, this article offers an argument through the speech framework of Basic Health Care Center Managers in the city of Curitiba-PR, by

  11. Topic structure for information retrieval

    NARCIS (Netherlands)

    He, J.; Sanderson, M.; Zhai, C.; Zobel, J.; Allan, J.; Aslam, J.A.

    2009-01-01

    In my research, I propose a coherence measure, with the goal of discovering and using topic structures within and between documents, of which I explore its extensions and applications in information retrieval.

  12. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    1994-01-01

    The collection of abstracts on selected topics in nuclear structure are given. Special attention pays to collective excitations and high-spin states of nuclei, giant resonance structure, nuclear reaction mechanisms and so on

  13. Case Of Iatrogenic Cushing's Syndrome By Topical Triamcinolone.

    Science.gov (United States)

    Zil-E-Ali, Ahsan; Janjua, Omer Hanif; Latif, Aiza; Aadil, Muhammad

    2018-01-01

    Cushing's syndrome is a collection of signs and symptoms due to hypercortisolism. Prolong use of topical steroid may cause this syndrome and suppression of hypothalamic and pituitary function, however such events are more common with oral and parenteral route. There are very few cases of Cushing's syndrome with a topical application amongst which triamcinolone is the rarest drug. We report a case of 11-year-old boy is presented who developed Cushing's disease by topical application. The child had body rashes for which the caregiver consulted a local quack, a topical cream of triamcinolone was prescribed. After application for three months, the patient became obese and developed a moon-like face. A thorough biochemical workup and diagnostic test for Cushing's disease was done to confirm. The following case report a dramatic example of development of the syndrome from chronic topical application of the least potent corticosteroid.

  14. Scaling and root planning, and locally delivered minocycline reduces the load of Prevotella intermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial

    NARCIS (Netherlands)

    Deng, S.; Wang, Y.; Sun, W.; Chen, H.; Wu, G.

    2015-01-01

    Background: To evaluate the respective or combinatory efficacy of locally delivered 2% minocycline (MO) and scaling and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis (CP). Methods: Seventy adults with CP

  15. Recent topics in differential and analytic geometry

    CERN Document Server

    Ochiai, T

    1990-01-01

    Advanced Studies in Pure Mathematics, Volume 18-I: Recent Topics in Differential and Analytic Geometry presents the developments in the field of analytical and differential geometry. This book provides some generalities about bounded symmetric domains.Organized into two parts encompassing 12 chapters, this volume begins with an overview of harmonic mappings and holomorphic foliations. This text then discusses the global structures of a compact Kähler manifold that is locally decomposable as an isometric product of Ricci-positive, Ricci-negative, and Ricci-flat parts. Other chapters con

  16. Key Topics in Sports Medicine

    OpenAIRE

    2006-01-01

    Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

  17. Topics of Bioengineering in Wikipedia

    Directory of Open Access Journals (Sweden)

    Vassia Atanassova

    2009-10-01

    Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

  18. Topics in modern differential geometry

    CERN Document Server

    Verstraelen, Leopold

    2017-01-01

    A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

  19. Energy future Santa Cruz. A citizens plan for energy self-reliance: Executive summary

    Science.gov (United States)

    Cohn, J.; Stayton, R.

    A grassroots energy conservation project which involved more than 3100 residents of Santa Cruz, California, is discussed. Citizens attended forums and town meetings to suggest ideas for solving the community's energy problems. These ideas were then evaluated by the Energy Future Advisory Board and compiled into the Energy Future Plan. The plan covers such topics as new residences, residential retrofit, automobile efficiency, farm efficiency, commercial greenhouses, local food production, commercial efficiency, land use planning, energy eduction and financing, and solar, wind, and ocean energy. If the plan is successfully implemented, the energy that the community is projected to use in 1991 can be lowered by 24 to 35 percent.

  20. [Endoscopic endonasal detection of cerebrospinal fluid leakage with topical fluorescein].

    Science.gov (United States)

    Sato, Taku; Kishida, Yugo; Watanabe, Tadashi; Tani, Akiko; Tada, Yasuhiro; Tamura, Takamitsu; Ichikawa, Masahiro; Sakuma, Jun; Omori, Koichi; Saito, Kiyoshi

    2013-08-01

    We evaluated the effectiveness of intraoperative topical application of fluorescein to detect the leakage point of cerebrospinal fluid(CSF)rhinorrhea. Three patients with CSF rhinorrhea were treated with an endoscopic endonasal technique. Ten percent fluorescein was topically used for intraoperative localization of the leak site. A change of the fluorescein color from brown to green due to dilation of CSF were recognized as evidence of CSF rhinorrhea. We repeated the procedure to detect any small defects. All CSF rhinorrheas were successfully repaired by this endoscopic endonasal approach. Topical application of fluorescein is simple and sensitive for identifying intraoperative CSF rhinorrhea.

  1. Planning Systems for Distributed Operations

    Science.gov (United States)

    Maxwell, Theresa G.

    2002-01-01

    This viewgraph representation presents an overview of the mission planning process involving distributed operations (such as the International Space Station (ISS)) and the computer hardware and software systems needed to support such an effort. Topics considered include: evolution of distributed planning systems, ISS distributed planning, the Payload Planning System (PPS), future developments in distributed planning systems, Request Oriented Scheduling Engine (ROSE) and Next Generation distributed planning systems.

  2. Magnetic Resonance Imaging-Based Target Volume Delineation in Radiation Therapy Treatment Planning for Brain Tumors Using Localized Region-Based Active Contour

    Energy Technology Data Exchange (ETDEWEB)

    Aslian, Hossein [Department of Medical Radiation, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Sadeghi, Mahdi [Agricultural, Medical and Industrial Research School, Karaj (Iran, Islamic Republic of); Mahdavi, Seied Rabie [Department of Medical Physics, Iran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Babapour Mofrad, Farshid [Department of Medical Radiation, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Astarakee, Mahdi, E-mail: M-Astarakee@Engineer.com [Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Khaledi, Navid [Department of Medical Radiation, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Fadavi, Pedram [Department of Radiation Oncology, Iran University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2013-09-01

    Purpose: To evaluate the clinical application of a robust semiautomatic image segmentation method to determine the brain target volumes in radiation therapy treatment planning. Methods and Materials: A local robust region-based algorithm was used on MRI brain images to study the clinical target volume (CTV) of several patients. First, 3 oncologists delineated CTVs of 10 patients manually, and the process time for each patient was calculated. The averages of the oncologists’ contours were evaluated and considered as reference contours. Then, to determine the CTV through the semiautomatic method, a fourth oncologist who was blind to all manual contours selected 4-8 points around the edema and defined the initial contour. The time to obtain the final contour was calculated again for each patient. Manual and semiautomatic segmentation were compared using 3 different metric criteria: Dice coefficient, Hausdorff distance, and mean absolute distance. A comparison also was performed between volumes obtained from semiautomatic and manual methods. Results: Manual delineation processing time of tumors for each patient was dependent on its size and complexity and had a mean (±SD) of 12.33 ± 2.47 minutes, whereas it was 3.254 ± 1.7507 minutes for the semiautomatic method. Means of Dice coefficient, Hausdorff distance, and mean absolute distance between manual contours were 0.84 ± 0.02, 2.05 ± 0.66 cm, and 0.78 ± 0.15 cm, and they were 0.82 ± 0.03, 1.91 ± 0.65 cm, and 0.7 ± 0.22 cm between manual and semiautomatic contours, respectively. Moreover, the mean volume ratio (=semiautomatic/manual) calculated for all samples was 0.87. Conclusions: Given the deformability of this method, the results showed reasonable accuracy and similarity to the results of manual contouring by the oncologists. This study shows that the localized region-based algorithms can have great ability in determining the CTV and can be appropriate alternatives for manual approaches in brain cancer.

  3. Magnetic Resonance Imaging-Based Target Volume Delineation in Radiation Therapy Treatment Planning for Brain Tumors Using Localized Region-Based Active Contour

    International Nuclear Information System (INIS)

    Aslian, Hossein; Sadeghi, Mahdi; Mahdavi, Seied Rabie; Babapour Mofrad, Farshid; Astarakee, Mahdi; Khaledi, Navid; Fadavi, Pedram

    2013-01-01

    Purpose: To evaluate the clinical application of a robust semiautomatic image segmentation method to determine the brain target volumes in radiation therapy treatment planning. Methods and Materials: A local robust region-based algorithm was used on MRI brain images to study the clinical target volume (CTV) of several patients. First, 3 oncologists delineated CTVs of 10 patients manually, and the process time for each patient was calculated. The averages of the oncologists’ contours were evaluated and considered as reference contours. Then, to determine the CTV through the semiautomatic method, a fourth oncologist who was blind to all manual contours selected 4-8 points around the edema and defined the initial contour. The time to obtain the final contour was calculated again for each patient. Manual and semiautomatic segmentation were compared using 3 different metric criteria: Dice coefficient, Hausdorff distance, and mean absolute distance. A comparison also was performed between volumes obtained from semiautomatic and manual methods. Results: Manual delineation processing time of tumors for each patient was dependent on its size and complexity and had a mean (±SD) of 12.33 ± 2.47 minutes, whereas it was 3.254 ± 1.7507 minutes for the semiautomatic method. Means of Dice coefficient, Hausdorff distance, and mean absolute distance between manual contours were 0.84 ± 0.02, 2.05 ± 0.66 cm, and 0.78 ± 0.15 cm, and they were 0.82 ± 0.03, 1.91 ± 0.65 cm, and 0.7 ± 0.22 cm between manual and semiautomatic contours, respectively. Moreover, the mean volume ratio (=semiautomatic/manual) calculated for all samples was 0.87. Conclusions: Given the deformability of this method, the results showed reasonable accuracy and similarity to the results of manual contouring by the oncologists. This study shows that the localized region-based algorithms can have great ability in determining the CTV and can be appropriate alternatives for manual approaches in brain cancer

  4. Community development planning

    International Nuclear Information System (INIS)

    Gray, S.I.

    1983-01-01

    The focus of this paper will be methods of local community involvement in the community development planning efforts which will be required at the recommended sites. Community development planning will include capital improvement plans, housing plans, zoning changes, business development plans and other community service and fiscal plans required to meet the projected needs of new residents as a result of the repository construction and operation. This paper will present, (1) the need for community planning, (2) methods of responding to community planning needs, (3) current community planning issues to be addressed. 2 references, 1 figure

  5. Deep Unfolding for Topic Models.

    Science.gov (United States)

    Chien, Jen-Tzung; Lee, Chao-Hsi

    2018-02-01

    Deep unfolding provides an approach to integrate the probabilistic generative models and the deterministic neural networks. Such an approach is benefited by deep representation, easy interpretation, flexible learning and stochastic modeling. This study develops the unsupervised and supervised learning of deep unfolded topic models for document representation and classification. Conventionally, the unsupervised and supervised topic models are inferred via the variational inference algorithm where the model parameters are estimated by maximizing the lower bound of logarithm of marginal likelihood using input documents without and with class labels, respectively. The representation capability or classification accuracy is constrained by the variational lower bound and the tied model parameters across inference procedure. This paper aims to relax these constraints by directly maximizing the end performance criterion and continuously untying the parameters in learning process via deep unfolding inference (DUI). The inference procedure is treated as the layer-wise learning in a deep neural network. The end performance is iteratively improved by using the estimated topic parameters according to the exponentiated updates. Deep learning of topic models is therefore implemented through a back-propagation procedure. Experimental results show the merits of DUI with increasing number of layers compared with variational inference in unsupervised as well as supervised topic models.

  6. Evaluation of HACCP Plans of Food Industries: Case Study Conducted by the Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service) of the Local Health Authority of Foggia, Italy

    Science.gov (United States)

    Panunzio, Michele F.; Antoniciello, Antonietta; Pisano, Alessandra; Rosa, Giovanna

    2007-01-01

    With respect to food safety, many works have studied the effectiveness of self-monitoring plans of food companies, designed using the Hazard Analysis and Critical Control Point (HACCP) method. On the other hand, in-depth research has not been made concerning the adherence of the plans to HACCP standards. During our research, we evaluated 116 self-monitoring plans adopted by food companies located in the territory of the Local Health Authority (LHA) of Foggia, Italy. The general errors (terminology, philosophy and redundancy) and the specific errors (transversal plan, critical limits, hazard specificity, and lack of procedures) were standardized. Concerning the general errors, terminological errors pertain to half the plans examined, 47% include superfluous elements and 60% have repetitive subjects. With regards to the specific errors, 77% of the plans examined contained specific errors. The evaluation has pointed out the lack of comprehension of the HACCP system by the food companies and has allowed the Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service), in its capacity as a control body, to intervene with the companies in order to improve designing HACCP plans. PMID:17911662

  7. Quantum mechanics II advanced topics

    CERN Document Server

    Rajasekar, S

    2015-01-01

    Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

  8. Topical application of hemostatic paste

    Directory of Open Access Journals (Sweden)

    Mohammad Mizanur Rahman

    2017-02-01

    Full Text Available As a measure to control minor surgical bleeding, surgeons usually depend on a number of hemostatic aids. Topical use of bovine thrombin is a widely used procedure to arrest such minor bleeding. A 35 year old male sergeant of Bangladesh Air Force presented with repeated development of hematoma in his left thigh without any history of trauma or previous history of bleeding. Critical analysis of the patient’s history, routine and sophisticated hematological investigations revealed that the patient developed anti-thrombin antibody following the application of hemostatic paste in the tooth socket five years back during minor dental procedure to stop ignorable bleeding episodes. Therefore, topical use of hemostatic glue/paste or bovine thrombin should be avoided to desist minor bleeding as recombinant human thrombin is now available for topical use.

  9. Osteoarthritis guidelines: a progressive role for topical nonsteroidal anti-inflammatory drugs

    Directory of Open Access Journals (Sweden)

    Stanos SP

    2013-04-01

    Full Text Available Steven P Stanos Rehabilitation Institute of Chicago, Center for Pain Management, Chicago, IL, USA Abstract: Current treatment guidelines for the treatment of chronic pain associated with osteoarthritis reflect the collective clinical knowledge of international experts in weighing the benefits of pharmacologic therapy options while striving to minimize the negative effects associated with them. Consideration of disease progression, pattern of flares, level of functional impairment or disability, response to treatment, coexisting conditions such as cardiovascular disease or gastrointestinal disorders, and concomitant prescription medication use should be considered when creating a therapeutic plan for a patient with osteoarthritis. Although topical nonsteroidal anti-inflammatory drugs historically have not been prevalent in many of the guidelines for osteoarthritis treatment, recent evidence-based medicine and new guidelines now support their use as a viable option for the clinician seeking alternatives to typical oral formulations. This article provides a qualitative review of these treatment guidelines and the emerging role of topical nonsteroidal anti-inflammatory drugs as a therapy option for patients with localized symptoms of osteoarthritis who may be at risk for oral nonsteroidal anti-inflammatory drug-related serious adverse events. Keywords: osteoarthritis, nonsteroidal anti-inflammatory drugs, guidelines, topical analgesics, diclofenac

  10. Primary Student Teachers' Ideas about Teaching a Physics Topic

    Science.gov (United States)

    Ahtee, Maija; Johnston, Jane

    2006-01-01

    This study examines Finnish and English primary student teachers' ideas when planning to teach a physics topic during their science education studies. Many primary student teachers lack sufficient subject knowledge, which prevents them from constructing the scientific pedagogical content knowledge that enables them to concentrate on pupils'…

  11. Transdermal and Topical Drug Administration in the Treatment of Pain

    Directory of Open Access Journals (Sweden)

    Wojciech Leppert

    2018-03-01

    Full Text Available The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms. Opioids administered transdermally are absorbed into vessels located in subcutaneous tissue and, subsequently, are conveyed in the blood to opioid receptors localized in the central and peripheral nervous system. Non–steroidal anti–inflammatory drugs (NSAIDs applied topically render analgesia mainly through a high concentration in the structures of the joint and a provision of local anti–inflammatory effects. Topically administered drugs such as lidocaine and capsaicin in patches, capsaicin in cream, EMLA cream, and creams containing antidepressants (i.e., doxepin, amitriptyline act mainly locally in tissues through receptors and/or ion channels. Transdermal and topical routes offer some advantages over systemic analgesic administration. Analgesics administered topically have a much better profile for adverse effects as they relieve local pain with minimal systemic effects. The transdermal route apart from the above-mentioned advantages and provision of long period of analgesia may be more convenient, especially for patients who are unable to take drugs orally. Topically and transdermally administered opioids are characterised by a lower risk of addiction compared to oral and parenteral routes.

  12. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Solov'ev, V.G.; Gromov, K.Ya.; Malov, L.A.; Shilov, V.M.

    1994-01-01

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles. heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and β-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei

  13. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  14. Selected topics in nuclear structure

    Energy Technology Data Exchange (ETDEWEB)

    Solov` ev, V G; Gromov, K Ya; Malov, L A; Shilov, V M

    1994-12-31

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles). heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and {beta}-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei.

  15. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  16. Comparison of two dimensional and three dimensional radiotherapy treatment planning in locally advanced non-small cell lung cancer treated with continuous hyperfractionated accelerated radiotherapy weekend less

    International Nuclear Information System (INIS)

    Wilson, Elena M.; Joy Williams, Frances; Ethan Lyn, Basil; Aird, Edwin G.A.

    2005-01-01

    Background and purpose: Patients with inoperable non-small cell lung cancer being treated with continuous hyperfractionated accelerated radiotherapy weekend less (CHARTWEL) were planned and treated with a three dimensional (3D) conformal protocol and comparison made with two dimensional (2D) planning, as used previously, to compare past practice and methods. Patients and methods: Twenty-four patients were planned initially using 3D and then replanned using a 2D system. The 2D plans were transferred onto the 3D system and recalculated. Dose volume histograms could then be constructed of planning target volumes for phases 1 and 2 (PTV 1 and 2, respectively), lung and spinal cord for the 2D plans and compared with the 3D plans. Results: There was a significantly lower absolute dose to the isocentre with 2D compared to 3D planning with dose reductions of 3.9% for phase 1, 4.4% for phase 2 and 4.7% for those treated with a single phase. Maximum dose to spinal cord was greater in 17 of the 24 2D plans with a median dose reduction of 0.82 Gy for 3D (P=0.04). The percentage volume of whole lung receiving ≥20 Gy (V 20 ) was greater in 16 of the 24 2D plans with a median reduction in V 20 of 2.4% for 3D (P=0.03). Conclusions: A lower dose to tumour was obtained using 2D planning due to the method of dose calculation and spinal cord and lung doses were significantly higher

  17. Selected topics in grand unification

    International Nuclear Information System (INIS)

    Seckel, D.

    1983-01-01

    This dissertation is a collection of four pieces of research dealing with grand unification. The topics are neutron oscillation, CP violation, magnetic monopole abundance and distribution in neutron stars, and a proposal for an inflationary cosmology driven by stress-energy in domain walls

  18. Topics in elementary particle physics

    International Nuclear Information System (INIS)

    Dugan, M.J.

    1985-01-01

    Topics in elementary particle physics are discussed. Models with N = 2 supersymmetry are constructed. The CP violation properties of a class of N = 1 supergravity models are analyzed. The structure of a composite Higgs model is investigated. The implications of a 17 keV neutrino are considered

  19. Resources for Topics in Nursing.

    Science.gov (United States)

    Riordan, Dale B.

    This guide is intended to help the user become familiar with a selected group of reference tools and resources which are useful in nursing education and practice. It is important for students to use the correct medical or scientific terminology, understand the scope of a topic, and then utilize the tools necessary to research subjects of interest.…

  20. Seven topics in perturbative QCD

    International Nuclear Information System (INIS)

    Buras, A.J.

    1980-09-01

    The following topics of perturbative QCD are discussed: (1) deep inelastic scattering; (2) higher order corrections to e + e - annihilation, to photon structure functions and to quarkonia decays; (3) higher order corrections to fragmentation functions and to various semi-inclusive processes; (4) higher twist contributions; (5) exclusive processes; (6) transverse momentum effects; (7) jet and photon physics

  1. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Stachura, Z.

    1984-09-01

    19. winter school in Zakopane was devoted to selected topics in nuclear structure such as: production of spin resonances, heavy ions reactions and their applications to the investigation of high spin states, octupole deformations, excited states and production of new elements etc. The experimental data are ofen compared with theoretical predictions. Report contains 28 papers. (M.F.W.)

  2. Hot Topics in Science Teaching

    Science.gov (United States)

    Ediger, Marlow

    2018-01-01

    There are vital topics in science teaching and learning which are mentioned frequently in the literature. Specialists advocate their importance in the curriculum as well as science teachers stress their saliency. Inservice education might well assist new and veteran teachers in knowledge and skills. The very best science lessons and units of…

  3. Topic Map for Authentic Travel

    OpenAIRE

    Wandsvik, Atle; Zare, Mehdi

    2007-01-01

    E-business is a new trend in Internet use. Authentic travel is an approach to travel and travel business which helps the traveler experience what is authentic in the travel destination. But how can the traveler find those small authentic spots and organize them together to compose a vacation? E-business techniques, combined withTopic Maps, can help.

  4. Two topics in quantum chromodynamics

    International Nuclear Information System (INIS)

    Bjorken, J.D.

    1989-12-01

    The two topics are (1) estimates of perturbation theory coefficients for R(e + e - → hadrons), and (2) the virtual-photon structure function, with emphasis on the analytic behavior in its squared mass. 20 refs., 4 figs., 2 tabs

  5. Topical Session on Materials Management

    International Nuclear Information System (INIS)

    2002-01-01

    At its second meeting, in Paris, 5-7 December 2001, the WPDD held two topical sessions on the D and D Safety Case and on the Management of Materials from D and D, respectively. This report documents the topical session on the management of materials. Presentations during the topical session covered key aspects of the management of materials and meant to provide an exchange of information and experience, including: Experience and lessons learnt from VLLW and non-radioactive material management in Spain and Germany with special attention to recycling (How specific solutions came about? Are there 'generic' examples for wider adoption?); Risk assessment of recycling and non-recycling: a CPD study; Waste acceptance issues within different national contexts (What constraints are there on the waste receiving body and what flexibility can the latter have? What constraints does this impose on D and D implementers? What about wastes are without current solution? What needs to be done? What about large items and 'difficult' waste in general?); Radiological characterisation of materials during decommissioning, particularly difficult situations - large volumes, large items,.. wastes, heterogeneous streams (What examples of established practice? What are the approaches or aspects that set the regulatory requirements? How can the flow rates be large but the answers acceptable? How much is needed to be known for later action, e. g., disposal, release, protection of worker, etc.); Radiological characterisation of buildings as they stand, in order to allow conventional demolition (What are strategies for optimisation of characterisation? How much needs to be known to take action later? e.g. for storage, disposal, release, cost estimation and ALARA? What needs to be done in advance and after decommissioning/dismantling?). At the end of each presentation time was allotted for discussion of the paper. Integral to the Topical Session was a facilitated plenary discussion on the topical

  6. Guidelines and criteria for planning Slovenian settlements

    Directory of Open Access Journals (Sweden)

    Andrej Pogačnik

    2001-01-01

    Full Text Available The article deals with proposals for directing settlement development and management in Slovenia on the national level. They should be integrated in the spatial order, a part of the national spatial plan. First a short chronology of research with similar topics and simultaneous critical analysis is presented. The methodology and possible models for structuring directives is elaborated. Based on recent research by domestic authors, European guidelines and own ideas, a manual was devised, dividing guidelines hierarchically between the national, regional and local level. The second part or rather different type of text attached to the manual is a glossary. It also includes an index for further research of various sources.

  7. Presentations of Topic 3: Policies Planning Implementing and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 nov. 2010 ... A global vision for small business in Egypt. Once overlooked and undervalued, small-scale businesses are now front and centre as Egypt takes bold steps to transform its economy, with the strat. View moreA global vision for small business in Egypt ...

  8. Finance and supply management project execution plan; TOPICAL

    International Nuclear Information System (INIS)

    BENNION, S.I.

    1999-01-01

    As a subproject of the HANDI 2000 project, the Finance and Supply Management system is intended to serve FDH and Project Hanford major subcontractor with financial processes including general ledger, project costing, budgeting, and accounts payable, and supply management process including purchasing, inventory and contracts management. Currently these functions are performed with numerous legacy information systems and suboptimized processes

  9. Topical phenytoin for treating pressure ulcers.

    Science.gov (United States)

    Hao, Xiang Yong; Li, Hong Ling; Su, He; Cai, Hui; Guo, Tian Kang; Liu, Ruifeng; Jiang, Lei; Shen, Yan Fei

    2017-02-22

    Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin. Phenytoin is a drug more commonly used in the treatment of epilepsy, but may play an important role in accelerating ulcer healing. To assess the effects of topical phenytoin on the rate of healing of pressure ulcers of any grade, in any care setting. In September 2016, we searched the following electronic databases to identify relevant randomized clinical trials: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library); Ovid MEDLINE; Ovid Embase; and EBSCO CINAHL Plus. We handsearched conference proceedings from the European Pressure Ulcer Advisory Panel, European Wound Management Association and the Tissue Viability Society for all available years. We searched the references of the retrieved trials to identify further relevant trials. We also searched clinical trials registries to identify ongoing and unpublished studies. There were no restrictions with respect to language, date of publication or study setting. We included all randomized controlled trials (RCTs) addressing the effects (both benefits and harms) of topical phenytoin on the healing of pressure ulcers of any grade compared with placebo or alternative treatments or no therapy, irrespective of blinding, language, and publication status. Two review authors independently selected studies, extracted information on participants, interventions, methods and results and assessed risk of bias using

  10. Geotechnical support and topical studies for nuclear waste geologic repositories

    International Nuclear Information System (INIS)

    1989-01-01

    The present report lists the technical reviews and comments made during the fiscal year 1988 and summarizes the technical progress of the topical studies. In the area of technical assistance, there were numerous activities detailed in the next section. These included 24 geotechnical support activities, including reviews of 6 Study Plans (SP) and participation in 6 SP Review Workshops, review of one whole document Site Characterization Plan (SCP) and participation in the Assembled Document SCP Review Workshops by 6 LBL reviewers; the hosting of a DOE program review, the rewriting of the project statement of work, 2 trips to technical and planning meetings; preparation of proposed work statements for two new topics for DOE, and 5 instances of technical assistance to DOE. These activities are described in a Table in the following section entitled ''Geoscience Technical Support for Nuclear Waste Geologic Repositories.''

  11. The Report of Suicide by Ingestion of Lidocaine Topical Spray

    Directory of Open Access Journals (Sweden)

    Hossein Hassanian-Moghaddam

    2014-09-01

    Full Text Available Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sprays used as local anesthetics in dentistry. Cases: Three cases of suicidal poisoning by ingestion of the content of lidocaine topical spray are reported in the present study. The cases developed episodes of seizure requiring diazepam and other therapeutic modalities upon admission. Eventually, one of the cases expired. Conclusion: To the best of our knowledge, this study is the first reported case of suicidal poisoning after ingestion of this formulation which highlights the fact that lidocaine topical spray formulation may be used for committing suicide. Ingestion of lidocaine present in topical spray can induce varying levels of toxicity that can even be fatal.

  12. Topics on Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Within the last decade we have experienced deregulation of several industries, such as airlines, telecommunications and the electric utility industry, the last-mentioned being the focus of this work. Both the telecommunications and the electricity sector depend on network facilities, some of which are still considered as natural monopolies. In these industries, open network access is regarded as crucial in order to achieve the gains from increased competition, and transmission tariffs are important in implementing this. Based on the Energy Act that was introduced in 1991, Norway was among the first countries to restructure its electricity sector. On the supply side there are a large number of competing firms, almost exclusively hydro plants, with a combined capacity of about 23000 MW, producing 105-125 TWh per year, depending on the availability of water. Hydro plants are characterized by low variable costs of operation, however since water may be stored in dams, water has an opportunity cost, generally known as the water value, which is the shadow price of water when solving the generator's inter temporal profit maximization problem. Water values are the main factor of the producers' short run marginal cost. Total consumption amounts to 112-117 TWh a year, and consumers, even households, may choose their electricity supplier independent of the local distributor to which the customer is connected. In fact, approximately 10% of the households have actually changed supplier. The web-site www.konkurransetilsynet.no indicates available contracts, and www.dinside.no provides an ''energy-calculator'' where one can check whether it is profitable to switch supplier. If a customer buys energy from a remote supplier, the local distributor only provides transportation facilities for the energy and is compensated accordingly. Transmission and distribution have remained monopolized and regulated by the Norwegian Water Resources and Energy

  13. Topics in Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Within the last decade we have experienced deregulation of several industries, such as airlines, telecommunications and the electric utility industry, the last-mentioned being the focus of this work. Both the telecommunications and the electricity sector depend on network facilities, some of which are still considered as natural monopolies. In these industries, open network access is regarded as crucial in order to achieve the gains from increased competition, and transmission tariffs are important in implementing this. Based on the Energy Act that was introduced in 1991, Norway was among the first countries to restructure its electricity sector. On the supply side there are a large number of competing firms, almost exclusively hydro plants, with a combined capacity of about 23000 MW, producing 105-125 TWh per year, depending on the availability of water. Hydro plants are characterized by low variable costs of operation, however since water may be stored in dams, water has an opportunity cost, generally known as the water value, which is the shadow price of water when solving the generator's inter temporal profit maximization problem. Water values are the main factor of the producers' short run marginal cost. Total consumption amounts to 112-117 TWh a year, and consumers, even households, may choose their electricity supplier independent of the local distributor to which the customer is connected. In fact, approximately 10% of the households have actually changed supplier. The web-site www.konkurransetilsynet.no indicates available contracts, and www.dinside.no provides an ''energy-calculator'' where one can check whether it is profitable to switch supplier. If a customer buys energy from a remote supplier, the local distributor only provides transportation facilities for the energy and is compensated accordingly. Transmission and distribution have remained monopolized and regulated by the Norwegian Water Resources and Energy

  14. Topics on Electricity Transmission Pricing

    International Nuclear Information System (INIS)

    Bjoerndal, Mette

    2000-02-01

    Within the last decade we have experienced deregulation of several industries, such as airlines, telecommunications and the electric utility industry, the last-mentioned being the focus of this work. Both the telecommunications and the electricity sector depend on network facilities, some of which are still considered as natural monopolies. In these industries, open network access is regarded as crucial in order to achieve the gains from increased competition, and transmission tariffs are important in implementing this. Based on the Energy Act that was introduced in 1991, Norway was among the first countries to restructure its electricity sector. On the supply side there are a large number of competing firms, almost exclusively hydro plants, with a combined capacity of about 23000 MW, producing 105-125 TWh per year, depending on the availability of water. Hydro plants are characterized by low variable costs of operation, however since water may be stored in dams, water has an opportunity cost, generally known as the water value, which is the shadow price of water when solving the generator's inter temporal profit maximization problem. Water values are the main factor of the producers' short run marginal cost. Total consumption amounts to 112-117 TWh a year, and consumers, even households, may choose their electricity supplier independent of the local distributor to which the customer is connected. In fact, approximately 10% of the households have actually changed supplier. The web-site www.konkurransetilsynet.no indicates available contracts, and www.dinside.no provides an ''energy-calculator'' where one can check whether it is profitable to switch supplier. If a customer buys energy from a remote supplier, the local distributor only provides transportation facilities for the energy and is compensated accordingly. Transmission and distribution have remained monopolized and regulated by the Norwegian Water Resources and Energy Directorate (NVE). To prevent cross

  15. Topical cyclosporine for atopic keratoconjunctivitis.

    Science.gov (United States)

    González-López, Julio J; López-Alcalde, Jesús; Morcillo Laiz, Rafael; Fernández Buenaga, Roberto; Rebolleda Fernández, Gema

    2012-09-12

    Atopic keratoconjunctivitis (AKC) is a chronic ocular surface non-infectious inflammatory condition that atopic dermatitis patients may suffer at any time point in the course of their dermatologic disease and is independent of its degree of severity. AKC is usually not self resolving and it poses a higher risk of corneal injuries and severe sequelae. Management of AKC should prevent or treat corneal damage. Although topical corticosteroids remain the standard treatment for patients with AKC, prolonged use may lead to complications. Topical cyclosporine A (CsA) may improve AKC signs and symptoms, and be used as a corticosteroid sparing agent. To determine the efficacy and gather evidence on safety from randomised controlled trials (RCTs) of topical CsA in patients with AKC. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 6), MEDLINE (January 1946 to July 2012), EMBASE (January 1980 to July 2012), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to July 2012), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (January 1937 to July 2012), OpenGrey (System for Information on Grey Literature in Europe) (www.opengrey.eu/), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en), the IFPMA Clinical Trials Portal (http://clinicaltrials.ifpma.org/no_cache/en/myportal/index.htm) and Web of Science Conference Proceedings Citation Index- Science (CPCI-S). We did not use any date or language restrictions in the electronic searches for trials. The electronic databases were last searched on 9 July 2012. We also handsearched the following conference proceedings: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, International Council of Opthalmology and Societas

  16. The superiority of hybrid-volumetric arc therapy (VMAT) technique over double arcs VMAT and 3D-conformal technique in the treatment of locally advanced non-small cell lung cancer – A planning study

    International Nuclear Information System (INIS)

    Chan, Oscar S.H.; Lee, Michael C.H.; Hung, Albert W.M.; Chang, Amy T.Y.; Yeung, Rebecca M.W.; Lee, Anne W.M.

    2011-01-01

    Purpose: To compare the dosimetric performance of three different treatment techniques – conformal radiotherapy (CRT), double arcs volumetric modulated arc therapy (RapidArc, RA) and Hybrid-RapidArc (H-RA) for locally-advanced non-small cell lung cancer (NSCLC). Material and methods: CRT, RA and H-RA plans were optimized for 24 stage III NSCLC patients. The target prescription dose was 60 Gy. CRT consisted of 5–7 coplanar fields, while RA comprised of two 204 o arcs. H-RA referred to two 204 o arcs plus 2 static fields, which accounted for approximately half of the total dose. The plans were optimized to fulfill the departmental plan acceptance criteria. Results: RA and H-RA yielded a 20% better conformity compared with CRT. Lung volume receiving >20 Gy (V20) and mean lung dose (MLD) were the lowest in H-RA (V20 1.7% and 2.1% lower, MLD 0.59 Gy and 0.41 Gy lower than CRT and RA respectively) without jeopardizing the low-dose lung volume (V5). H-RA plans gave the lowest mean maximum spinal cord dose (34.4 Gy, 3.9 Gy < CRT and 2.2 Gy < RA plans) and NTCP of lung. Higher average MU per fraction (addition 52.4 MU) was observed with a reduced treatment time compared with CRT plans. Conclusion: The H-RA technique was superior in dosimetric outcomes for treating locally-advanced NSCLC compared to CRT and RA.

  17. WE-F-BRB-03: Inclusion of Data-Driven Risk Predictions in Radiation Treatment Planning in the Context of a Local Level Learning Health System

    International Nuclear Information System (INIS)

    McNutt, T.

    2015-01-01

    Advancements in informatics in radiotherapy are opening up opportunities to improve our ability to assess treatment plans. Models on individualizing patient dose constraints from prior patient data and shape relationships have been extensively researched and are now making their way into commercial products. New developments in knowledge based treatment planning involve understanding the impact of the radiation dosimetry on the patient. Akin to radiobiology models that have driven intensity modulated radiotherapy optimization, toxicity and outcome predictions based on treatment plans and prior patient experiences may be the next step in knowledge based planning. In order to realize these predictions, it is necessary to understand how the clinical information can be captured, structured and organized with ontologies and databases designed for recall. Large databases containing radiation dosimetry and outcomes present the opportunity to evaluate treatment plans against predictions of toxicity and disease response. Such evaluations can be based on dose volume histogram or even the full 3-dimensional dose distribution and its relation to the critical anatomy. This session will provide an understanding of ontologies and standard terminologies used to capture clinical knowledge into structured databases; How data can be organized and accessed to utilize the knowledge in planning; and examples of research and clinical efforts to incorporate that clinical knowledge into planning for improved care for our patients. Learning Objectives: Understand the role of standard terminologies, ontologies and data organization in oncology Understand methods to capture clinical toxicity and outcomes in a clinical setting Understand opportunities to learn from clinical data and its application to treatment planning Todd McNutt receives funding from Philips, Elekta and Toshiba for some of the work presented

  18. Topical antifungal agents: an update.

    Science.gov (United States)

    Diehl, K B

    1996-10-01

    So many topical antifungal agents have been introduced that it has become very difficult to select the proper agent for a given infection. Nonspecific agents have been available for many years, and they are still effective in many situations. These agents include Whitfield's ointment, Castellani paint, gentian violet, potassium permanganate, undecylenic acid and selenium sulfide. Specific antifungal agents include, among others, the polyenes (nystatin, amphotericin B), the imidazoles (metronidazole, clotrimazole) and the allylamines (terbinafine, naftifine). Although the choice of an antifungal agent should be based on an accurate diagnosis, many clinicians believe that topical miconazole is a relatively effective agent for the treatment of most mycotic infections. Terbinafine and other newer drugs have primary fungicidal effects. Compared with older antifungal agents, these newer drugs can be used in lower concentrations and shorter therapeutic courses. Studies are needed to evaluate the clinical efficacies and cost advantages of both newer and traditional agents.

  19. Topics in computational linear optimization

    DEFF Research Database (Denmark)

    Hultberg, Tim Helge

    2000-01-01

    Linear optimization has been an active area of research ever since the pioneering work of G. Dantzig more than 50 years ago. This research has produced a long sequence of practical as well as theoretical improvements of the solution techniques avilable for solving linear optimization problems...... of high quality solvers and the use of algebraic modelling systems to handle the communication between the modeller and the solver. This dissertation features four topics in computational linear optimization: A) automatic reformulation of mixed 0/1 linear programs, B) direct solution of sparse unsymmetric...... systems of linear equations, C) reduction of linear programs and D) integration of algebraic modelling of linear optimization problems in C++. Each of these topics is treated in a separate paper included in this dissertation. The efficiency of solving mixed 0-1 linear programs by linear programming based...

  20. Do scientists trace hot topics?

    Science.gov (United States)

    Wei, Tian; Li, Menghui; Wu, Chensheng; Yan, Xiao-Yong; Fan, Ying; Di, Zengru; Wu, Jinshan

    2013-01-01

    Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do follow hot topics. However, there are qualitative differences among scientists from various countries, among research works regarding different number of authors, different number of affiliations and different number of references. These observations could be valuable for policy makers when deciding research funding and also for individual researchers when searching for scientific projects.

  1. OHVT technology roadmap[2000]; TOPICAL

    International Nuclear Information System (INIS)

    Bradley, R.A.

    2000-01-01

    The OHVT Technology Roadmap for 2000 presents the multiyear program plan of the U.S. DOE's Office of Heavy Vehicle Technologies (OHVT). It is an update of the 1997 plan, reflecting changes in regulations and ongoing discussions with DOE's heavy vehicle customers. The technical plan covers three classes of trucks: (1) class 7-8 (large, on-highway trucks); (2) class 3-6 (medium duty trucks); (3) class 1-2 (pickups, vans, and sport utility vehicles) as well as enabling and supporting technologies. The Roadmap documents program goals, schedules, and milestones

  2. The Development of Biology Teaching Material Based on the Local Wisdom of Timorese to Improve Students Knowledge and Attitude of Environment in Caring the Preservation of Environment

    Science.gov (United States)

    Ardan, Andam S.

    2016-01-01

    The purposes of this study were (1) to describe the biology learning such as lesson plans, teaching materials, media and worksheets for the tenth grade of High School on the topic of Biodiversity and Basic Classification, Ecosystems and Environment Issues based on local wisdom of Timorese; (2) to analyze the improvement of the environmental…

  3. Recent topics in nonlinear PDE

    International Nuclear Information System (INIS)

    Mimura, Masayasu; Nishida, Takaaki

    1984-01-01

    The meeting on the subject of nonlinear partial differential equations was held at Hiroshima University in February, 1983. Leading and active mathematicians were invited to talk on their current research interests in nonlinear pdes occuring in the areas of fluid dynamics, free boundary problems, population dynamics and mathematical physics. This volume contains the theory of nonlinear pdes and the related topics which have been recently developed in Japan. (Auth.)

  4. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1983-01-01

    Probabilistic Analysis and Related Topics, Volume 3 focuses on the continuity, integrability, and differentiability of random functions, including operator theory, measure theory, and functional and numerical analysis. The selection first offers information on the qualitative theory of stochastic systems and Langevin equations with multiplicative noise. Discussions focus on phase-space evolution via direct integration, phase-space evolution, linear and nonlinear systems, linearization, and generalizations. The text then ponders on the stability theory of stochastic difference systems and Marko

  5. Topics in clinical oncology. 15

    International Nuclear Information System (INIS)

    Cepcek, P.

    1987-12-01

    The monograph comprising primarily papers on topical subjects of oncology and cancer research, contains also a selection of papers presented at the 2. Congress of the Czechoslovak Society of Nuclear Medicine and Radiation Hygiene. Seven papers were selected on behalf of their subject related to clinical oncology. All of them were iputted in INIS; five of them deal with the scintiscanning of the skeleton of cancer patients, one with radioimmunodetection of tumors, and one with radionuclide lymphography. (A.K.)

  6. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1979-01-01

    Probabilistic Analysis and Related Topics, Volume 2 focuses on the integrability, continuity, and differentiability of random functions, as well as functional analysis, measure theory, operator theory, and numerical analysis.The selection first offers information on the optimal control of stochastic systems and Gleason measures. Discussions focus on convergence of Gleason measures, random Gleason measures, orthogonally scattered Gleason measures, existence of optimal controls without feedback, random necessary conditions, and Gleason measures in tensor products. The text then elaborates on an

  7. Stochastic Analysis and Related Topics

    CERN Document Server

    Ustunel, Ali

    1988-01-01

    The Silvri Workshop was divided into a short summer school and a working conference, producing lectures and research papers on recent developments in stochastic analysis on Wiener space. The topics treated in the lectures relate to the Malliavin calculus, the Skorohod integral and nonlinear functionals of white noise. Most of the research papers are applications of these subjects. This volume addresses researchers and graduate students in stochastic processes and theoretical physics.

  8. Cumulative irritation potential of topical retinoid formulations.

    Science.gov (United States)

    Leyden, James J; Grossman, Rachel; Nighland, Marge

    2008-08-01

    Localized irritation can limit treatment success with topical retinoids such as tretinoin and adapalene. The factors that influence irritant reactions have been shown to include individual skin sensitivity, the particular retinoid and concentration used, and the vehicle formulation. To compare the cutaneous tolerability of tretinoin 0.04% microsphere gel (TMG) with that of adapalene 0.3% gel and a standard tretinoin 0.025% cream. The results of 2 randomized, investigator-blinded studies of 2 to 3 weeks' duration, which utilized a split-face method to compare cumulative irritation scores induced by topical retinoids in subjects with healthy skin, were combined. Study 1 compared TMG 0.04% with adapalene 0.3% gel over 2 weeks, while study 2 compared TMG 0.04% with tretinoin 0.025% cream over 3 weeks. In study 1, TMG 0.04% was associated with significantly lower cumulative scores for erythema, dryness, and burning/stinging than adapalene 0.3% gel. However, in study 2, there were no significant differences in cumulative irritation scores between TMG 0.04% and tretinoin 0.025% cream. Measurements of erythema by a chromameter showed no significant differences between the test formulations in either study. Cutaneous tolerance of TMG 0.04% on the face was superior to that of adapalene 0.3% gel and similar to that of a standard tretinoin cream containing a lower concentration of the drug (0.025%).

  9. Internet plan and planning

    Directory of Open Access Journals (Sweden)

    Kahriman Emina

    2008-01-01

    Full Text Available Paper discuss specific features of internet plan as well as planning as management process in general in the contemporary environment. No need to stress out that marketing plan and marketing planning is core activity in approaching to market. At the same time, there are a lot specific c request in preparing marketing plan comparing to business planning due to marketing plan is an essential part. The importance of internet plan and planning rely on specific features of the internet network but as a part of general corporate as well as marketing strategy.

  10. Solid-State Lighting 2017 Suggested Research Topics

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-09-29

    A 2017 update to the Solid-State Lighting R&D Plan that is divided into two documents. The first document describes a list of suggested SSL priority research topics and the second document provides context and background, including information drawn from technical, market, and economic studies. Widely referenced by industry and government both here and abroad, these documents reflect SSL stakeholder inputs on key R&D topics that will improve efficacy, reduce cost, remove barriers to adoption, and add value for LED and OLED lighting solutions over the next three to five years, and discuss those applications that drive and prioritize the specific R&D.

  11. Thailand Momentum on Policy and Practice in Local Legislation on Dengue Vector Control

    Directory of Open Access Journals (Sweden)

    Adisak Bhumiratana

    2014-01-01

    Full Text Available Over a past decade, an administrative decentralization model, adopted for local administration development in Thailand, is replacing the prior centralized (top-down command system. The change offers challenges to local governmental agencies and other public health agencies at all the ministerial, regional, and provincial levels. A public health regulatory and legislative framework for dengue vector control by local governmental agencies is a national topic of interest because dengue control program has been integrated into healthcare services at the provincial level and also has been given priority in health plans of local governmental agencies. The enabling environments of local administrations are unique, so this critical review focuses on the authority of local governmental agencies responsible for disease prevention and control and on the functioning of local legislation with respect to dengue vector control and practices.

  12. Precession electron diffraction – a topical review

    Directory of Open Access Journals (Sweden)

    Paul A. Midgley

    2015-01-01

    Full Text Available In the 20 years since precession electron diffraction (PED was introduced, it has grown from a little-known niche technique to one that is seen as a cornerstone of electron crystallography. It is now used primarily in two ways. The first is to determine crystal structures, to identify lattice parameters and symmetry, and ultimately to solve the atomic structure ab initio. The second is, through connection with the microscope scanning system, to map the local orientation of the specimen to investigate crystal texture, rotation and strain at the nanometre scale. This topical review brings the reader up to date, highlighting recent successes using PED and providing some pointers to the future in terms of method development and how the technique can meet some of the needs of the X-ray crystallography community. Complementary electron techniques are also discussed, together with how a synergy of methods may provide the best approach to electron-based structure analysis.

  13. Topics in modelling of clustered data

    CERN Document Server

    Aerts, Marc; Ryan, Louise M; Geys, Helena

    2002-01-01

    Many methods for analyzing clustered data exist, all with advantages and limitations in particular applications. Compiled from the contributions of leading specialists in the field, Topics in Modelling of Clustered Data describes the tools and techniques for modelling the clustered data often encountered in medical, biological, environmental, and social science studies. It focuses on providing a comprehensive treatment of marginal, conditional, and random effects models using, among others, likelihood, pseudo-likelihood, and generalized estimating equations methods. The authors motivate and illustrate all aspects of these models in a variety of real applications. They discuss several variations and extensions, including individual-level covariates and combined continuous and discrete outcomes. Flexible modelling with fractional and local polynomials, omnibus lack-of-fit tests, robustification against misspecification, exact, and bootstrap inferential procedures all receive extensive treatment. The application...

  14. Disposal Criticality Analysis Methodology Topical Report

    International Nuclear Information System (INIS)

    Horton, D.G.

    1998-01-01

    The fundamental objective of this topical report is to present the planned risk-informed disposal criticality analysis methodology to the NRC to seek acceptance that the principles of the methodology and the planned approach to validating the methodology are sound. The design parameters and environmental assumptions within which the waste forms will reside are currently not fully established and will vary with the detailed waste package design, engineered barrier design, repository design, and repository layout. Therefore, it is not practical to present the full validation of the methodology in this report, though a limited validation over a parameter range potentially applicable to the repository is presented for approval. If the NRC accepts the methodology as described in this section, the methodology will be fully validated for repository design applications to which it will be applied in the License Application and its references. For certain fuel types (e.g., intact naval fuel), a ny processes, criteria, codes or methods different from the ones presented in this report will be described in separate addenda. These addenda will employ the principles of the methodology described in this report as a foundation. Departures from the specifics of the methodology presented in this report will be described in the addenda

  15. Disposal Criticality Analysis Methodology Topical Report

    International Nuclear Information System (INIS)

    D.G. Horton

    1998-01-01

    The fundamental objective of this topical report is to present the planned risk-informed disposal criticality analysis methodology to the NRC to seek acceptance that the principles of the methodology and the planned approach to validating the methodology are sound. The design parameters and environmental assumptions within which the waste forms will reside are currently not fully established and will vary with the detailed waste package design, engineered barrier design, repository design, and repository layout. Therefore, it is not practical to present the full validation of the methodology in this report, though a limited validation over a parameter range potentially applicable to the repository is presented for approval. If the NRC accepts the methodology as described in this section, the methodology will be fully validated for repository design applications to which it will be applied in the License Application and its references. For certain fuel types (e.g., intact naval fuel), any processes, criteria, codes or methods different from the ones presented in this report will be described in separate addenda. These addenda will employ the principles of the methodology described in this report as a foundation. Departures from the specifics of the methodology presented in this report will be described in the addenda

  16. Energy future Santa Cruz: A citizens' plan for energy self-reliance

    Science.gov (United States)

    Cohn, J.; Stayton, R.

    The results of a grassroots energy conservation project which involved more than 3,100 residents of Santa Cruz, California, is discussed. Citizens attended forums and town meetings to suggest ideas for solving the community's energy problems. These ideas were then evaluated by the Energy Future Advisory Board and compiled into the Energy Future Plan. The energy plan covers such topics as new residences, residential retrofit, automobile efficiency, farm efficiency, commercial greenhouses, local food production, commercial efficiency, land use planning, energy education and financing, and solar, wind, and ocean energy. An energy implementation guide and glossary are included.

  17. Film forming systems for topical and transdermal drug delivery

    Directory of Open Access Journals (Sweden)

    Kashmira Kathe

    2017-11-01

    Full Text Available Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system's ability to adhere to skin during the therapy so as to promote drug penetration through the skin barrier. Conventional formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient compliance. For the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance. In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions along with their evaluation parameters have also been reviewed.

  18. National Capital Planning Commission Library contents

    Data.gov (United States)

    National Capital Planning Commission — The National Capital Planning Commission library catalog is a compilation of titles, authors, years of publication and topics of books, reports and NCPC publications.

  19. Tactile friction of topical formulations.

    Science.gov (United States)

    Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L

    2016-02-01

    The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Topic extraction from adverbial clauses

    Directory of Open Access Journals (Sweden)

    Carlos Rubio Alcalá

    2016-06-01

    Full Text Available This paper offers new data to support findings about Topic extraction from adverbial clauses. Since such clauses are strong islands, they should not allow extraction of any kind, but we show here that if the appropriate conditions are met, Topics of the CLLD kind in Romance can move out of them. We propose that two conditions must be met for such movement to be possible: the first is that the adverbial clause must have undergone topicalisation in the first place; the second is that the adverbial clause is inherently topical from a semantic viewpoint. Contrast with other language families (Germanic, Quechua and Japanese is provided and the semantic implications of the proposal are briefly discussed. Keywords: topicalisation; Clitic Left Dislocation; syntactic islands; adverbial clauses Este artículo ofrece nuevos datos sobre la extracción de Tópicos desde oraciones subordinadas adverbiales. Dado que dichas oraciones son islas fuertes, no deberían permitir extracción de ningún tipo, pero mostramos que si se dan las condiciones apropiadas, los Tópicos del tipo CLLD en lenguas románicas pueden desplazarse fuera de ellas. Proponemos que se deben cumplir dos condiciones para que ese movimiento sea posible: la primera es que la propia subordinada adverbial se haya topicalizado en primer lugar; la segunda es que la subordinada adverbial sea inherentemente un Tópico desde el punto de vista semántico. Proporcionamos también algunos contrastes con otras familias lingüísticas (germánica, quechua y japonés y se discuten brevemente las implicaciones semánticas de la propuesta. Palabras clave: topicalización; dislocación a la izquierda con clítico; islas sintácticas; oraciones adverbiales