WorldWideScience

Sample records for local company picked

  1. The Kaizen Connection: How Companies Pick Tomorrow's Workers.

    Science.gov (United States)

    Feuer, Dale; Lee, Chris

    1988-01-01

    Kaizen is a Japanese management concept that means gradual, ongoing improvement involving everyone from top management to production workers. This concept is starting to appear in American companies, and it requires the personnel department to do a much more thorough assessment of job applicants, testing for leadership skills, interpersonal…

  2. The Kaizen Connection: How Companies Pick Tomorrow's Workers.

    Science.gov (United States)

    Feuer, Dale; Lee, Chris

    1988-01-01

    Kaizen is a Japanese management concept that means gradual, ongoing improvement involving everyone from top management to production workers. This concept is starting to appear in American companies, and it requires the personnel department to do a much more thorough assessment of job applicants, testing for leadership skills, interpersonal…

  3. Automatic traveltime picking using local time-frequency maps

    KAUST Repository

    Saragiotis, Christos

    2011-01-01

    The arrival times of distinct and sufficiently concentrated signals can be computed using Fourier transforms. In real seis- mograms, however, signals are far from distinct. We use local time-frequency maps of the seismograms and its frequency derivatives to obtain frequency-dependent (instantaneous) traveltimes. A smooth division is utilized to control the resolution of the instantaneous traveltimes to allow for a trade-off between resolution and stability. We average these traveltimes over the frequency band which is data-dependent. The resulting traveltime attribute is used to isolate different signals in seismic traces. We demonstrate the effectiveness of this automatic method for picking arrivals by applying it on synthetic and real data. © 2011 Society of Exploration Geophysicists.

  4. Membrane localization is critical for activation of the PICK1 BAR domain

    DEFF Research Database (Denmark)

    Madsen, Kenneth L; Eriksen, Jacob; Milan-Lobo, Laura

    2008-01-01

    The PSD-95/Discs-large/ZO-1 homology (PDZ) domain protein, protein interacting with C kinase 1 (PICK1) contains a C-terminal Bin/amphiphysin/Rvs (BAR) domain mediating recognition of curved membranes; however, the molecular mechanisms controlling the activity of this domain are poorly understood....... In agreement with negative regulation of the BAR domain by the N-terminal PDZ domain, PICK1 distributed evenly in the cytoplasm, whereas truncation of the PDZ domain caused BAR domain-dependent redistribution to clusters colocalizing with markers of recycling endosomal compartments. A similar clustering...... was observed both upon truncation of a short putative alpha-helical segment in the linker between the PDZ and the BAR domains and upon coexpression of PICK1 with a transmembrane PDZ ligand, including the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR2 subunit, the GluR2 C...

  5. Robust 3D object localization and pose estimation for random bin picking with the 3DMaMa algorithm

    Science.gov (United States)

    Skotheim, Øystein; Thielemann, Jens T.; Berge, Asbjørn; Sommerfelt, Arne

    2010-02-01

    Enabling robots to automatically locate and pick up randomly placed and oriented objects from a bin is an important challenge in factory automation, replacing tedious and heavy manual labor. A system should be able to recognize and locate objects with a predefined shape and estimate the position with the precision necessary for a gripping robot to pick it up. We describe a system that consists of a structured light instrument for capturing 3D data and a robust approach for object location and pose estimation. The method does not depend on segmentation of range images, but instead searches through pairs of 2D manifolds to localize candidates for object match. This leads to an algorithm that is not very sensitive to scene complexity or the number of objects in the scene. Furthermore, the strategy for candidate search is easily reconfigurable to arbitrary objects. Experiments reported in this paper show the utility of the method on a general random bin picking problem, in this paper exemplified by localization of car parts with random position and orientation. Full pose estimation is done in less than 380 ms per image. We believe that the method is applicable for a wide range of industrial automation problems where precise localization of 3D objects in a scene is needed.

  6. Green Computing in Local Governments and Information Technology Companies

    Directory of Open Access Journals (Sweden)

    Badar Agung Nugroho

    2013-06-01

    Full Text Available Green computing is a study and practice of designing, manufacturing, using, and disposing of information and communication devices efficiently and effectively with minimum impact on the environment. If the green computing concept was implemented, it will help the agencies or companies to reduce energy and capital cost from their IT infrastructure. The goal from this research is to explore the current condition about the efforts from local governments and IT companies at West Java to implement the green computing concept at their working environment. The primary data were collected by using focus group discussion by inviting the local governments and IT companies representatives who responsible to manage their IT infrastructure. And then, the secondary data were collected by doing brief observation in order to see the real effort of green computing implementation at each institution. The result shows that there are many different perspectives and efforts of green computing implementation between local governments and IT companies.

  7. Pick disease

    Science.gov (United States)

    ... in behavior Failure to show emotional warmth, concern, empathy, sympathy Inappropriate mood Not caring about events or ... and steadily becomes worse. The person becomes totally disabled early in the course of the disease. Pick ...

  8. Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C.

    Science.gov (United States)

    Dardis, A; Zampieri, S; Canterini, S; Newell, K L; Stuani, C; Murrell, J R; Ghetti, B; Fiorenza, M T; Bembi, B; Buratti, E

    2016-05-18

    Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by the occurrence of visceral and neurological symptoms. At present, the molecular mechanisms causing neurodegeneration in this disease are unknown. Here we report the altered expression and/or mislocalization of the TAR-DNA binding protein 43 (TDP-43) in both NPC mouse and in a human neuronal model of the disease. We also report the neuropathologic study of a NPC patient's brain, showing that while TDP-43 is below immunohistochemical detection in nuclei of cerebellar Purkinje cells, it has a predominant localization in the cytoplasm of these cells. From a functional point of view, the TDP-43 mislocalization, that occurs in a human experimental neuronal model system, is associated with specific alterations in TDP-43 controlled genes. Most interestingly, treatment with N-Acetyl-cysteine (NAC) or beta-cyclodextrin (CD) can partially restore TDP-43 nuclear localization. Taken together, the results of these studies extend the role of TDP-43 beyond the Amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD)/Alzheimer disease (AD) spectrum. These findings may open novel research/therapeutic avenues for a better understanding of both NPC disease and the TDP-43 proteinopathy disease mechanism.

  9. Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

    Energy Technology Data Exchange (ETDEWEB)

    Kosicek, Marko, E-mail: marko.kosicek@irb.hr [Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia); Malnar, Martina, E-mail: martina.malnar@irb.hr [Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia); Goate, Alison, E-mail: goate@icarus.wustl.edu [Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110 (United States); Hecimovic, Silva, E-mail: silva.hecimovic@irb.hr [Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia)

    2010-03-12

    It has been suggested that cholesterol may modulate amyloid-{beta} (A{beta}) formation, a causative factor of Alzheimer's disease (AD), by regulating distribution of the three key proteins in the pathogenesis of AD ({beta}-amyloid precursor protein (APP), {beta}-secretase (BACE1) and/or presenilin 1 (PS1)) within lipid rafts. In this work we tested whether cholesterol accumulation upon NPC1 dysfunction, which causes Niemann Pick type C disease (NPC), causes increased partitioning of APP into lipid rafts leading to increased CTF/A{beta} formation in these cholesterol-rich membrane microdomains. To test this we used CHO NPC1{sup -/-} cells (NPC cells) and parental CHOwt cells. By sucrose density gradient centrifugation we observed a shift in fl-APP/CTF compartmentalization into lipid raft fractions upon cholesterol accumulation in NPC vs. wt cells. Furthermore, {gamma}-secretase inhibitor treatment significantly increased fl-APP/CTF distribution in raft fractions in NPC vs. wt cells, suggesting that upon cholesterol accumulation in NPC1-null cells increased formation of APP-CTF and its increased processing towards A{beta} occurs in lipid rafts. Our results support that cholesterol overload, such as in NPC disease, leads to increased partitioning of APP/CTF into lipid rafts resulting in increased amyloidogenic processing of APP in these cholesterol-rich membranes. This work adds to the mechanism of the cholesterol-effect on APP processing and the pathogenesis of Alzheimer's disease and supports the role of lipid rafts in these processes.

  10. Niemann-Pick Disease

    Science.gov (United States)

    ... Disease] National Niemann-Pick Disease Foundation, Inc. National Tay-Sachs and Allied Diseases Association See all related ... Disease] National Niemann-Pick Disease Foundation, Inc. National Tay-Sachs and Allied Diseases Association See all related ...

  11. Appearing like a state: Oil companies and local violence in the Niger Delta

    Science.gov (United States)

    Mattner, Mark

    What determines the extent to which communities in the Niger Delta experience violence? The dissertation addresses this question by focusing on the role of multinational oil companies in local governance, where state institutions are weak. The available literature often overlooks this important dimension. Specifically, the dissertation evaluates whether the choice of community relation policies by oil companies accounts for variations in local violence. These policies often include community development projects and attempts at strengthening local institutions. The main hypothesis is that where projects are allocated and implemented through participatory processes, informal institutions are created which substitute for weak local governments and reduce violence. The dissertation tests this contention by comparing four cases which were selected according to differences in their levels of violence. It concludes that the hypothesis is valid only in highly specific circumstances. In most cases, levels of repression and the relationship between companies and local elites are more significant explanations for violence. This is because oil companies and the state continue to rely primarily on repression and co-optation in their relationship with local communities. Community development and corporate social responsibility are secondary concerns. The central implication of this analysis is that a solution to the crisis in the Niger Delta is unlikely to lie in self-regulation and non-binding commitments by corporate actors. More promising approaches are strengthening local governments by ensuring the integrity of local elections and more stringent regulation of oil company conduct.

  12. Competing with giants. Survival strategies for local companies in emerging markets.

    Science.gov (United States)

    Dawar, N; Frost, T

    1999-01-01

    The arrival of a multinational corporation often looks like a death sentence to local companies in an emerging market. After all, how can they compete in the face of the vast financial and technological resources, the seasoned management, and the powerful brands of, say, a Compaq or a Johnson & Johnson? But local companies often have more options than they might think, say the authors. Those options vary, depending on the strength of globalization pressures in an industry and the nature of a company's competitive assets. In the worst case, when globalization pressures are strong and a company has no competitive assets that it can transfer to other countries, it needs to retreat to a locally oriented link within the value chain. But if globalization pressures are weak, the company may be able to defend its market share by leveraging the advantages it enjoys in its home market. Many companies in emerging markets have assets that can work well in other countries. Those that operate in industries where the pressures to globalize are weak may be able to extend their success to a limited number of other markets that are similar to their home base. And those operating in global markets may be able to contend head-on with multinational rivals. By better understanding the relationship between their company's assets and the industry they operate in, executives from emerging markets can gain a clearer picture of the options they really have when multinationals come to stay.

  13. Management of Corporate Culture through Local Managers' Training in Foreign Companies in China: A Qualitative Analysis

    Science.gov (United States)

    Zhao, Crystal L.

    2005-01-01

    Corporate culture is a complex phenomenon in foreign companies located in the People's Republic of China. For the management team of an international enterprise, it is a challenging task to manage cultural differences. Education and training provided to local managers might be one of the important solutions. Therefore, this study explores the…

  14. Skin Picking Disorder

    Directory of Open Access Journals (Sweden)

    Pinar Cetinay Aydin

    2014-08-01

    Full Text Available Skin picking disorder is not a dermatological disorder and it is a table characterized with picking skin excessively and repetitively, leading to damage in skin tissue. Unlike normal picking behaviour, psychogenic skin picking is repetitive and it can lead to severe damage in the skin and even complications which constitute vital danger. While some patients define frequent but short lasting picking attacks, others define rarer attacks which last a few hours. Skin picking disorder, which is not included in the classification systems up to DSM-5 as a separate diagnosis category, is included as an independent diagnosis in Obsessive Compulsive Disorder and Associated Disorders category in DSM-5. In case reports, open label studies and double blind studies selective serotonin reuptake inhibitors are shown to be effective in the treatment of skin picking disorder. Mostly, cognitive-behaviourial techniques are used and have been proven to be useful in psychotherapy. Habit reversal is one of the behaviourial techniques which are frequently applied, give positive results in which well-being state can be maintained. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(4.000: 401-428

  15. Corporate social responsibility in global and local companies of Southeast Europe

    Directory of Open Access Journals (Sweden)

    Čibukčić Fuad

    2017-01-01

    Full Text Available The aim of this work is the analysis of theoretical assumptions and empirical research to find the answer to the question on how the activities in the field of corporate social responsibility in the region of Southeast Europe are present in the business of global and local companies market. Whether and to what extent to implement socially responsible behavior of companies with a different ownership structure, the revenue volume, market share, market activities and markets where it operates, and if the objectives of the companies are in line with the goals of social communities. they offer other than legal, and more benefits for their employees and provide them extra protection, whether, and to what extent, the state helps in carrying out socially useful activities and the compliance of the company's positive legal norms and international standards? The result of the research offered the conclusion that social responsibility activities in companies market of SE Europe are present in an increasing scope, a CSR program contributes to the awareness of the importance and necessity of such activities in the construction of a positive corporate image and relations of the companies with communities and stakeholders in the region.

  16. THE ROLE OF LOCAL COMMUNITY IN THE DEVELOPMENT OF SMALL AND MEDIUM COMPANIES

    Directory of Open Access Journals (Sweden)

    Nenad Koprivica

    2011-01-01

    Full Text Available We are witnesses of the change ineconomic system, and the transition fromcooperative to market economy and the era ofprivate capital. Major business systems that used tobe the foundation of development mostly do notwork today. The privatisation of the companies didnot give any results. Small and medium companiesshould be a replacement for the major systems andemploy a great number of the workers that havebeen left unemployed. Central authorities havedone very few things for the support anddevelopment of small and medium companies. Thechange in the role of local community has alsohappened, and it has a key role in providing morequality living, through the development of economyof the growth and development of small andmedium companies and decrease in unemployment.The increase of employment can be achieved byincreasing the number of companies or byexpanding the existing ones. Local communitiesshould take various measures to establish abeneficial environment for their development,including various programs, supports, allowances,facilities for potential investors, etc. It is necessaryto ascertain the models of cooperation and supportwith the aim of their development and increase incapacities. The aim of this paper is to show that alocal community which uses the instruments for thedevelopment of institutional, entrepreneurial andmaterial infrastructure for the growth anddevelopment of companies can improve theirdevelopment, and also the economic and generaldevelopment, and thus provide a more quality lifeof its inhabitants.

  17. Management of local economic and ecological system of coal processing company

    Science.gov (United States)

    Kiseleva, T. V.; Mikhailov, V. G.; Karasev, V. A.

    2016-10-01

    The management issues of local ecological and economic system of coal processing company - coal processing plant - are considered in the article. The objectives of the research are the identification and the analysis of local ecological and economic system (coal processing company) performance and the proposals for improving the mechanism to support the management decision aimed at improving its environmental safety. The data on the structure of run-of-mine coal processing products are shown. The analysis of main ecological and economic indicators of coal processing enterprises, characterizing the state of its environmental safety, is done. The main result of the study is the development of proposals to improve the efficiency of local enterprise ecological and economic system management, including technical, technological and business measures. The results of the study can be recommended to industrial enterprises to improve their ecological and economic efficiency.

  18. Skin picking disorder.

    Science.gov (United States)

    Grant, Jon E; Odlaug, Brian L; Chamberlain, Samuel R; Keuthen, Nancy J; Lochner, Christine; Stein, Dan J

    2012-11-01

    Although skin picking has been documented in the medical literature since the 19th century, only now is it receiving serious consideration as a DSM psychiatric disorder in discussions for DSM-5. Recent community prevalence studies suggest that skin picking disorder appears to be as common as many other psychiatric disorders, with reported prevalences ranging from 1.4% to 5.4%. Clinical evaluation of patients with skin picking disorder entails a broad physical and psychiatric examination, encouraging an interdisciplinary approach to evaluation and treatment. Approaches to treatment should include cognitive-behavioral therapy (including habit reversal or acceptance-enhanced behavior therapy) and medication (serotonin reuptake inhibitors, N-acetylcysteine, or naltrexone). Based on clinical experience and research findings, the authors recommend several management approaches to skin picking disorder.

  19. Local Nordic tobacco interests collaborated with multinational companies to maintain a united front and undermine tobacco control policies.

    Science.gov (United States)

    Hiilamo, Heikki; Glantz, Stanton A

    2013-03-01

    To analyse how local tobacco companies in the Nordic countries, individually and through National Manufacturers' Associations, cooperated with British American Tobacco and Philip Morris in denying the health hazards of smoking and undermining tobacco control. Analysis of tobacco control policies in the Nordic countries and tobacco industry documents. Nordic countries were early adopters of tobacco control policies. The multinational tobacco companies recognised this fact and mobilised to oppose these policies, in part because of fear that they would set unfavourable precedents. Since at least 1972, the Nordic tobacco companies were well informed about and willing to participate in the multinational companies activities to obscure the health dangers of smoking and secondhand smoke and to oppose tobacco control policies. Cooperation between multinational companies, Nordic national manufacturer associations and local companies ensured a united front on smoking and health issues in the Nordic area that was consistent with the positions that the multinational companies were taking. This cooperation delayed smoke-free laws and undermined other tobacco control measures. Local tobacco companies worked with multinational companies to undermine tobacco control in distant and small Nordic markets because of concern that pioneering policies initiated in Nordic countries would spread to bigger market areas. Claims by the local Nordic companies that they were not actively involved with the multinationals are not supported by the facts. These results also demonstrate that the industry appreciates the global importance of both positive and negative public health precedents in tobacco control.

  20. Study on monitoring achievement of performance indicators in the subordinate local companies in Romania

    Directory of Open Access Journals (Sweden)

    Gheorghe Neamţiu

    2011-12-01

    Full Text Available This paper deals with the pursuit of economic indicators which are calculated in local subordinate companies. These indicators are imposed by the Board employee manager contract term. Accounting provides enough information to calculate them but we put the issue of prevention of the ability to stay within budget, projected revenues and expenses, before closing operations of an accounting period (month, quarter, semester, year.

  1. [Skin-picking disorder].

    Science.gov (United States)

    Niemeier, V; Peters, E; Gieler, U

    2015-10-01

    The disorder is characterized by compulsive repetitive skin-picking (SP), resulting in skin lesions. The patients must have undertaken several attempts to reduce or stop SP. The disorder must have led to clinically significant limitations in social, professional, or other important areas of life. The symptoms cannot be better explained by another emotional disorder or any other dermatological disease. In the new DSM-V, skin-picking disorder has been included in the diagnostic system as an independent disorder and describes the self-injury of the skin by picking or scratching with an underlying emotional disorder. SP is classified among the impulse-control disorders and is, thus, differentiated from compulsive disorders as such. There are often emotional comorbidities. In cases of pronounced psychosocial limitation, interdisciplinary cooperation with a psychotherapist and/or psychiatrist is indicated.

  2. The options of local authorities for addressing climate change and energy efficiency through environmental regulation of companies

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Kasper

    2015-01-01

    Environmental regulation of companies is sometimes in the literature characterised as a successive broadening of focus and policy instruments: from applying command-and-control mechanism to get companies to clean and/or dilute local pollutants through end-of-pipe solutions; towards applying various...... means to influence and facilitate companies to act proactively in preventing pollution through cleaner production, waste prevention and resource efficiency. This understanding is contested in this article. The article documents instead a gap in respect to the local authorities actual execution...... of the direct regulation of companies in Denmark. The practise of the local competent authorities is found to primarily still target local environmental concerns by command-and-control means. The objective of the article is to analyse this discrepancy between the overall representation of regulatory trends...

  3. Accountability and governance in local public services: The particular case of mixed companies

    Directory of Open Access Journals (Sweden)

    Nuno Ferreira da Cruz

    2011-12-01

    Full Text Available The growing budget restrictions and decentralization processes that local governments face nowadays are threatening the sustainability of local public services. To overcome this problem, local decision-makers around the world have been developing ambiguous reforms, leading to various governance models. Since these services are essential for citizens’ welfare, it is crucial to determine whether or not these models have been effective and useful to cope with this state of affairs. To offer extra leverage to key projects, the European governments have been resorting to public-private partnerships (PPPs. One of the visible trends, which lacks further research, has been the use of mixed public-private companies (institutionalized PPPs. Although it is recognized that this solution can be interesting for both public and private sides, it has some particular features that can avert the aimed goals. This paper provides a literature review on mixed companies encompassing theoretical, legal and operational aspects. It also focuses on regulation by contract, referring to a particular Portuguese case study in the water sector and explaining how the municipality handled risk allocation and regulated the access to the market of private investors. Finally, it discusses the need for external regulation and makes suggestions on how these processes should be managed right from the bidding stage

  4. Can local environmental regulation of companies deal with a broader environmental view?

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Kasper; Smink, Carla

    , where strict regulations increasingly are supplemented with other regulatory instruments such as economic incentives, information and facilitation. In Denmark, municipalities are the competent authority for companies. Throughout the last decade, several attempts to expand competences of municipalities...... to include more facilitating and catalytic aspects as well as promoting cleaner technology and pollution prevention have been tried out. However today, most municipalities still rely on traditional command-and-control mechanisms as well as targeting at the traditional local environmental concerns. However...... the reason years renewed focus on Climate and Energy seems to provide perspectives to reintroduces this more facilitating role and focus on broader environmental aspects....

  5. Can local environmental regulation of companies deal with a broader environmental view?

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Kasper; Smink, Carla

    Environmental concern of companies has gradually expanded from a focus on local environmental problems to a broader inclusion of inputs as well as lifecycle perspectives. At the same time, the regulatory approach has changed from a “pure” command-and-control regime, towards a governance regime...... to include more facilitating and catalytic aspects as well as promoting cleaner technology and pollution prevention have been tried out. However today, most municipalities still rely on traditional command-and-control mechanisms as well as targeting at the traditional local environmental concerns. However...... the reason years renewed focus on Climate and Energy seems to provide perspectives to reintroduces this more facilitating role and focus on broader environmental aspects....

  6. Pick Cubes for Object Picking in VR World

    Directory of Open Access Journals (Sweden)

    M. Mohamed Sathik

    2010-02-01

    Full Text Available In this paper, we proposed an algorithm which performs object picking in Virtualreality world using cubes. As ‘Picking’ is an essential interaction technique in graphics applications,Object Picking is performed in VR world using a 3D mouse or an interactive glove to explore andinteract with any of the objects. In this paper, cube is used to represent the intersection point of the raycoming from the user input and the object to be picked. By intersecting the objects in the scene with theray with a pick cube at the intersection point, it is determined which one is picked. An object is selectedwhen this pick cube intersects the object’s bounding box. In this paper, object picking is typicallyperformed by bounding box checks, taking the position of the pick cube and the objects in account so thatthe algorithm is made simpler and the computation time of the algorithm is also reduced. Pick cube canbe activated to perform more actions during interactions than other shapes. So the efficiency and theperformance of the picking process will be increased which helps the user to play in the virtual worldwith full enthusiasm.

  7. Exploring Partnerships between Local Communities and Timber Companies: An Experiment Using the Role-Playing Games Approach

    Directory of Open Access Journals (Sweden)

    Herry Purnomo

    2009-01-01

    Full Text Available Cooperation among stakeholders is widely accepted as an effective management strategy. This paper describes an experimental study that explores this cooperation using role-playing games, which is formulated within a multiagent simulation framework. This framework enables participants to take active roles in mimicking the collaborative decision environment and the behaviors and attitudes of the different stakeholders. The paper examines a forest plantation company in South Sumatra, Indonesia, which has cooperated with local communities since 2000. The experimental pilot study described in this paper explored the role of communication in partnership relationships between the company and the local communities living within and around the surroundings of the company's plantation. These partnerships were explored and analyzed using the gaming approach involving university students taking the role of forest stakeholders, from both the timber company and the local communities. Lessons learned from the game provided the rationale for the establishment of a communication institution called “Forum Sebahu Sejalan.” This formal forum was constituted after a facilitated ex-postinteraction between representatives from the timber company and local communities. Results and observations drawn from the interactions show the potentials of the RPG approach and the formal forum in crafting resilient partnerships among stakeholders.

  8. Regional Companies of PetroChina Expand Local Oil Products Market Rapidly

    Institute of Scientific and Technical Information of China (English)

    Zhang Kaiyu

    2001-01-01

    @@ Jilin Company Jilin Oil Products Sales Company of PetroChina marketed 1.58 millions of oil products and generated 160 million yuan of profits and taxes in 2000, setting a record high in the company's history.The market occupancy in Jilin Province has risen to 90 percent from the previous 50 percent in the past few years.

  9. The Practice of Mining Companies in Building Relationships with Local Communities in the Context of CSR Formula

    Directory of Open Access Journals (Sweden)

    Marzena Majer

    2013-01-01

    Full Text Available This paper presents results regarding the analysis of activities of coal mining companies operating in Poland in terms of Corporate Social Responsibility (CSR, with a particular emphasis focused on the area of community involvement. This sphere is extremely important for entities operating in the sector due to the scale of the impact on the social environment and the potential threat of resistance from local communities. Mining companies have developed forms of action in this area and are subject to a number of legal regulations, especially in such critical points as mining damages or acquiring concessions for mining operations. Therefore, it is worth analysing these issues from the perspective of the CSR formula, and the way in which mining companies build a relationship with stakeholder groups which are undoubtedly the local communities. This represents a specific challenge for mining companies and requires a change in management approach based on the acceptance of responsibility for the impact they have and to seek solutions that will benefit both the companies themselves and their surroundings. It should also affect the change in approach for building relationships with local groups beyond just the legal requirements.

  10. Local sustainable energy companies. A few visions from the market; Lokale duurzame energiebedrijven. Een aantal visies uit de markt

    Energy Technology Data Exchange (ETDEWEB)

    Faasen, E.; Van Ee, M.; Chatelin, M. (eds.)

    2009-10-15

    In local sustainable energy companies it is all about renewable energy initiatives I which the local authorities play an important steering role. In this publication a number of experts from the renewable energy sector have their say. [Dutch] Bij lokale duurzame energiebedrijven gaat het om duurzame energie-initiatieven waarbij de decentrale overheid een belangrijke regisserende rol speelt. In deze publikatie wordt een aantal experts uit de duurzame energiesector aan het woord gelaten.

  11. Ultrafast optomechanical pulse picking

    Science.gov (United States)

    Lilienfein, Nikolai; Holzberger, Simon; Pupeza, Ioachim

    2017-01-01

    State-of-the-art optical switches for coupling pulses into and/or out of resonators are based on either the electro-optic or the acousto-optic effect in transmissive elements. In high-power applications, the damage threshold and other nonlinear and thermal effects in these elements impede further improvements in pulse energy, duration, and average power. We propose a new optomechanical switching concept which is based solely on reflective elements and is suitable for switching times down to the ten-nanosecond range. To this end, an isolated section of a beam path is moved in a system comprising mirrors rotating at a high angular velocity and stationary imaging mirrors, without affecting the propagation of the beam thereafter. We discuss three variants of the concept and exemplify practical parameters for its application in regenerative amplifiers and stack-and-dump enhancement cavities. We find that optomechanical pulse picking has the potential to achieve switching rates of up to a few tens of kilohertz while supporting pulse energies of up to several joules.

  12. Knowledge virtualization and local connectedness among smart high-tech companies

    NARCIS (Netherlands)

    Van Geenhuizen, M.S.; Nijkamp, P.

    2011-01-01

    Smart high-tech companies are characterized by knowledge intensity and open innovation. Even when these companies emerge in spatial clusters or dense urban places, they may utilize knowledge networks on a global scale. However, there is not much insight into the factors that shape knowledge networks

  13. Localization method of picking point of apple target based on smoothing contour symmetry axis algorithm%基于平滑轮廓对称轴法的苹果目标采摘点定位方法

    Institute of Scientific and Technical Information of China (English)

    王丹丹; 徐越; 宋怀波; 何东健

    2015-01-01

    果实采摘点的精确定位是采摘机器人必须解决的关键问题。鉴于苹果目标具有良好对称性的特点,利用转动惯量所具有的平移、旋转不变性及其在对称轴方向取得极值的特性,提出了一种基于轮廓对称轴法的苹果目标采摘点定位方法。为了解决分割后苹果目标边缘不够平滑而导致定位精度偏低的问题,提出了一种苹果目标轮廓平滑方法。为了验证算法的有效性,对随机选取的20幅无遮挡的单果苹果图像分别利用轮廓平滑和未进行轮廓平滑的算法进行试验,试验结果表明,未进行轮廓平滑算法的平均定位误差为20.678°,而轮廓平滑后算法平均定位误差为4.542°,比未进行轮廓平滑算法平均定位误差降低了78.035%,未进行轮廓平滑算法的平均运行时间为10.2 ms,而轮廓平滑后算法的平均运行时间为7.5 ms,比未进行轮廓平滑算法平均运行时间降低了25.839%,表明平滑轮廓算法可以提高定位精度和运算效率。利用平滑轮廓对称轴算法可以较好地找到苹果目标的对称轴并实现采摘点定位,表明将该方法应用于苹果目标的对称轴提取及采摘点定位是可行的。%The localization of picking points of fruits is one of the key problems for picking robots, and it is the first step of implementation of the picking task for picking robots. In view of a good symmetry of apples, and characteristics of shift, rotation invariance, and reaching the extreme values in symmetry axis direction which moment of inertia possesses, a new method based on a contour symmetry axis was proposed to locate the picking point of apples. In order to solve the problem of low localization accuracy which results from the rough edge of apples after segmentation, a method of smoothing contour algorithm was presented. The steps of the algorithm were as follow, first, the image was transformed from RGB color space into

  14. The Research on Improving the Order Picking Efficiency in Medical Logistics Area of CPL Based on Serial Partition Relay Picking Model

    Directory of Open Access Journals (Sweden)

    Xu Wei

    2013-01-01

    Full Text Available The medical business of China Post Logistics is developing day by day. China Post Logistics have been using the Parallel partition picking mode for a long time, but too many shortages have appearing in these two years, especially in the order picking cost and efficiency. This paper analyzes the current order picking mode of China Post Logistics and compare with the Parallel partition picking mode. By analysis the advantages and disadvantages of these two modes and combine with the actual situation, we choose the serial partition relay picking model as the picking mode of CPL in medical logistics area. And then it optimizes the order picking route in view of the current deficiency combined with the use of Ant Colony Optimization (ACO. The example simulation result shows that this optimizing is effective and the order picking cost decrease 17.36% and the route decrease 9.80% than that as before. This research not only to Chain Post Logistics but also to other logistics company which runs the medical business has certain reference.

  15. Application Performance Management Impact On Organizational Performance Local Company Studies In West Java - Indonesia

    Directory of Open Access Journals (Sweden)

    Teni Listiani

    2015-02-01

    Full Text Available Abstract This study aimed to analyze the effect on the performance of the companys performance management area. Management performance is measured through three dimensions performance planning performance assessment and feeding it behind. While organizational performance is measured through four dimensions financial perspective customer perspective internal business processes and learning and growth perspective. The unit of analysis in this research area comprising 30 companies from 23 taps 6 PD Market and 1 PD Health. Meanwhile the unit of observation is the top-middle-level managers-down of a total of 360 people. To determine the influence of the variables studied used Structural Equation Model SEM based on the model variant with Partial Least Square PLS. The results showed that in the enterprise area performance management affect the performance of the organization but the effect is not too large.

  16. Pick's Theorem: What a Lemon!

    Science.gov (United States)

    Russell, Alan R.

    2004-01-01

    Pick's theorem can be used in various ways just like a lemon. This theorem generally finds its way in the syllabus approximately at the middle school level and in fact at times students have even calculated the area of a state considering its outline with the help of the above theorem.

  17. Enhancing Warehouse Performance by Efficient Order Picking

    NARCIS (Netherlands)

    M. Yu (Mengfei)

    2008-01-01

    textabstractThis thesis studies order picking in warehouses. Order picking, the process of retrieval products from their storage locations to fill customer orders, is regarded as the most critical operation in a warehouse. Using stochastic modelling, we develop a model to estimate order picking syst

  18. Pathological skin picking: case presentation and review of the literature

    Directory of Open Access Journals (Sweden)

    Maria Isabela Sarbu

    2015-04-01

    Full Text Available Pathological skin picking is a condition in which patients induce skin lesions through repetitive, compulsive excoriations of normal skin or skin with minor surface irregularities and they admit their role in the production of the lesions, but are unable to stop their behavior. Psychiatric comorbidities most often associated with skin picking include obsessive-compulsive disorder (OCD, anxiety disorders, mood disorders, body dysmorphic disorders, trichotillomania and compulsive-buying disorder. We report the case of a 17 year old female patient who addressed the dermatology department of our hospital with an eruption consisting of erythematous papules and plaques. The local examination revealed several clues of paramount importance in drawing the final conclusion and the psychiatric examination helped establish the diagnosis of pathological skin picking in a patient with obsessive-compulsive disorder.

  19. Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway

    DEFF Research Database (Denmark)

    Madsen, Kenneth Lindegaard; Thorsen, Thor Seneca; Rahbek-Clemmensen, Troels;

    2012-01-01

    of PICK1 co-clusters in Rab11-positive compartments. Furthermore, PICK1 inhibited Rab11-mediated recycling of the receptor in a BAR and PDZ domain-dependent manner. In contrast, transfer of the DAT C terminus to the δ-opioid receptor, which sorts to degradation, did not result in PICK1 co-clusters or any...... primarily sorts to degradation upon internalization, did not form perinuclear clusters with PICK1, and PICK1 did not affect DAT internalization/recycling. However, transfer of the PICK1-binding DAT C terminus to the β(2)-adrenergic receptor, which sorts to recycling upon internalization, led to formation...... change in internalization/recycling. Further support for a role of PICK1 determined by its PDZ cargo was obtained for the PICK1 interaction partner prolactin-releasing peptide receptor (GPR10). GPR10 co-localized with Rab11 and clustered with PICK1 upon constitutive internalization but co...

  20. Cooperation and innovation in social economy companies Desarrollo local: reflexiones desde el desarrollo humano sostenible

    Directory of Open Access Journals (Sweden)

    Celso Vargas Elizondo

    2012-12-01

    Full Text Available This essay is a social and epistemological reflection on local economic development issued from the perspective of sustainable human development. It deals with some typical problems of development; and a differentiation is established expecting to suggest a road to the status of social citizenship and the threats that this aspiration conveys as well as an analysis of common insertion situations. As an exploratory essay, its main objective is to promote a theoretical reflexion on local economic development.At the same time,it gives an important relative weight to those strategies oriented to include that social sectors more vulnerable in the current process of globalisation.El presente documento contiene una reflexión epistemológica y social del tema del desarrollo económico local, desde la perspectiva del desarrollo humano sostenible. En él se abordan problemas típi- cos del desarrollo; se establece su diferenciación con la expectativa de insinuar al menos las vías de acce- so a la condición de ciudadanía social, las amenazas que esta aspiración experimenta y un recorrido por diversas situaciones de inserción que se suelen presentar. Es, pues, un ensayo exploratorio con el objetivo de promover la reflexión teórica sobre este importante tema. Otorga un gran peso relativo a las estrategias orientadas a incluir económica, social y políticamente a los sectores más vulnerables, en actual proceso de globalización.

  1. Enfermedad de Niemann-Pick

    OpenAIRE

    Margolles, Pedro; Paredes, Lucía; López, J.A. (Juan)

    2014-01-01

    Enfermedades Raras en Asturias. Dirección General de Salud Pública y Participación. Informes breves 11 Niemann-Pick is a hereditary disease in which accumulate sphingomyelin and lipids in the cells of different organs. Este proyecto ha sido financiado a cargo de los fondos para la cohesión territorial 2010 del Ministerio de Sanidad y Política Social que fueron aprobados en el CISNS, como apoyo a la implementación a la Estrategia en Enfermedades Raras del Sistema Nac...

  2. Short convalescence and minimal pain after out-patient Bascom's pit-pick operation

    DEFF Research Database (Denmark)

    Colov, Emilie Palmgren; Bertelsen, Claus Anders

    2011-01-01

    Treatment of pilonidal sinuses with Bascom's pit-pick operation can easily be performed under local analgesia. We describe pain during and after the operation, time to return to work, time to healing and success rate.......Treatment of pilonidal sinuses with Bascom's pit-pick operation can easily be performed under local analgesia. We describe pain during and after the operation, time to return to work, time to healing and success rate....

  3. Nail picking disorder (onychotillomania): a case report.

    Science.gov (United States)

    Snorrason, Ivar; Woods, Douglas W

    2014-03-01

    Nail picking disorder (onychotillomania) is characterized by excessive picking or pulling at one's own finger- or toenails. This condition has received scant research attention and may be related to other body focused repetitive behaviors such as pathological nail biting, skin picking and hair pulling. We present a case of a male client with a chronic and severe nail picking habit treated with acceptance-enhanced behavior therapy. The client showed clinical characteristics similar to other body focused repetitive behaviors and responded moderately well to the treatment.

  4. Improved Operating Performance of Mining Machine Picks

    Science.gov (United States)

    Prokopenko, S.; Li, A.; Kurzina, I.; Sushko, A.

    2016-08-01

    The reasons of low performance of mining machine picks are stated herein. In order to improve the wear resistance and the cutting ability of picks a new design of a cutting carbide tip insert to be fixed on a removable and rotating pick head is developed. Owing to the new design, the tool ensures a twofold increase in the cutting force maintained longer, a twofold reduction in the specific power consumption of the breaking process, and extended service life of picks and the possibility of their multiple use.

  5. Reducing Skin Picking via Competing Activities

    Science.gov (United States)

    Lane, Kathleen Lynne; Thompson, Ada; Reske, Cara L.; Gable, Lauren M.; Barton-Arwood, Sally

    2006-01-01

    This study examined the outcomes of a competing activities intervention to decrease skin picking exhibited by a 9-year-old student with comorbid diagnoses. Results of an ABCBAB design revealed that the use of student-selected manipulatives resulted in reduced skin picking. (Contains 1 figure.)

  6. White matter abnormalities in skin picking disorder

    DEFF Research Database (Denmark)

    Grant, Jon E; Odlaug, Brian Lawrence; Hampshire, Adam

    2013-01-01

    Skin picking disorder (SPD) is characterized by the repetitive and compulsive picking of skin, resulting in tissue damage. Neurocognitive findings in SPD implicate difficulty with response inhibition (suppression of pre-potent motor responses). This function is dependent on the integrity...

  7. Skin picking disorder in university students

    DEFF Research Database (Denmark)

    Odlaug, Brian Lawrence; Lust, Katherine; Schreiber, Liana R N

    2013-01-01

    This study sought to examine the prevalence of skin picking disorder (SPD) in a university sample and assess associated physical and mental health correlates.......This study sought to examine the prevalence of skin picking disorder (SPD) in a university sample and assess associated physical and mental health correlates....

  8. 论地方资产管理公司的运作与发展%Local Asset Management Company ’s Operation and Development

    Institute of Scientific and Technical Information of China (English)

    战友

    2014-01-01

    本文通过地方资产管理公司与四大资产管理公司的对比研究发现,地方资产管理公司的设立有助于加快地方金融机构不良资产处置,维护区域金融稳定;但同时也存在与四大资产管理公司业务重合、地方资产管理公司竞争优势不足、监管乏力等问题。对此,本文提出了明确金融属性、完善法律法规、建全监管体系等相关建议。%Compared with the four major asset management companies, the local asset management companies are helpful to speed up the disposal of bad assets of local financial institutions and maintain regional financial stability;but the two types of asset management companies’ business largely overlaps, the local asset management companies have little advantages and the supervision of the local asset management companies is weak. Some relevant policy recommen-dations, such as defining financial attributes, improving laws and regulations, establishing regulatory system etc are given.

  9. Application of local exhaust ventilation system and integrated collectors for control of air pollutants in mining company.

    Science.gov (United States)

    Ghorbani Shahna, Farshid; Bahrami, Abdulrahman; Farasati, Farhad

    2012-01-01

    Local exhaust ventilation (LEV) systems and integrated collectors were designed and implemented in a mining company in order to control emitted air pollutant from furnaces. The LEV was designed for capture and transition of air pollutants emitted from furnaces to the integrated collectors. The integrated collectors including four high efficiency Stairmand model cyclones for control of particulate matter, a venturi scrubber for control of the fine particles, SO(2) and a part of H(2)S to follow them, and a packed scrubber for treatment of the residual H(2)S and SO(2) were designed. Pollutants concentration were measured to determine system effectiveness. The results showed that the effectiveness of LEV for reducing workplace pollution is 91.83%, 96.32% and 83.67% for dust, SO(2) and H(2)S, respectively. Average removal efficiency of particles by combination of cyclone and venturi scrubber was 98.72%. Average removal efficiency of SO(2) and H(2)S were 95.85% and 47.13% for the venturi scrubber and 68.45% and 92.7% for the packed bed scrubber. The average removal efficiency of SO(2) and H(2)S were increased to 99.1% and 95.95% by the combination of venturi and packed bed scrubbers. According to the results, integrated collectors are a good air pollution control option for industries with economic constraints and ancient technologies.

  10. ORDER-PICKING OPTIMIZATION FOR AUTOMATED PICKING SYSTEM WITH PARALLEL DISPENSERS

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Based on the characteristics of parallel dispensers in automated picking system, an order-picking optimization problem is presented. Firstly, the working principle of parallel dispensers is introduced, which implies the time cost of picking each order is influenced by the order-picking sequence. So the order-picking optimization problem can be classified as a dynamic traveling salesman problem (TSP). Then a mathematical model of the problem is established and an improved max-min ant system (MMAS) is adopted to solve the model. The improvement includes two aspects. One is that the initial assignment of ants depends on a probabilistic formula instead of a random deployment; the other is that the heuristic factor is expressed by the extra picking time of each order instead of the total. At last, an actual simulation is made on an automated picking system with parallel dispensers. The simulation results proved the optimization value and the validity of improvement on MMAS.

  11. Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1

    DEFF Research Database (Denmark)

    Bassan, Merav; Liu, Hongguang; Madsen, Kenneth L

    2008-01-01

    with the PDZ domain protein PICK1, which plays a critical role in regulating the expression of glutamate receptors at excitatory synapses. A yeast two-hybrid screen of a neuronal library using the carboxyl tail of GLT1b yielded clones expressing PICK1. The GLT1b C-terminal peptide bound to PICK1 with high...... affinity (K(i) = 6.5 +/- 0.4 microM) in an in vitro fluorescence polarization assay. We also tested peptides based on other variants of GLT1 and other glutamate transporters. GLT1b co-immunoprecipitated with PICK1 from rat brain lysates and COS7 cell lysates derived from cells transfected with plasmids...... expressing PICK1 and GLT1b. In addition, expression of GLT1b in COS7 cells changed the distribution of PICK1, bringing it to the surface. GLT1b and PICK1 co-localized with each other and with synaptic markers in hippocampal neurons in culture. Phorbol ester, an activator of protein kinase C (PKC), a known...

  12. PICK1 promotes caveolin-dependent degradation of TGF-β typeⅠreceptor

    Institute of Scientific and Technical Information of China (English)

    Bing Zhao; Qiang Wang; Jun Du; Shiwen Luo; Jun Xia; Ye-Guang Chen

    2012-01-01

    Protein that interacts with C kinase 1 (PICK1) is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses.However,its ubiquitous expression suggests that it may have other non-neural functions.Here we show that PICK1 antagonizes transforming growth factor beta (TGF-β)signaling by targeting TGF-β type Ⅰ receptor (TβRI) for degradation.Biochemical analyses reveal that PICK1 directly interacts with the C-terminus of TβRI via its PDZ domain and acts as a scaffold protein to enhance the interaction between TβRI and caveolin-1,leading to enhanced lipid raft/caveolae localization.Therefore,PICK1 increases caveolin-mediated endocytosis,ubiquitination and degradation of TβRI.Moreover,a negative correlation between PICK1 expression and TβRI or phospho-Smad2 levels is observed in human breast tumors,indicating that PICK1 may participate in breast cancer development through inhibition of TGF-β signaling.Our findings reveal a non-neural function of PICK1 as an important negative regulator of TGF-β signaling.

  13. The PIP training programme: building of ACP experts capacities in crop protection and food safety to support local companies to comply with EU regulations on pesticides residues.

    Science.gov (United States)

    Schiffers, B C; Schubert, A; Schiffers, C; Fontaine, S; Gumusboga, N; Werner, B; Webb, M; Lugros, H; Stinglhamber, G

    2006-01-01

    Regulatory requirements, and in particular phytosanitary quality standards change rapidly. As ACP producers/exporters race to become more competitive, to keep their market share and to satisfay their customers' commercial demands (e.g. EUREP-GAP certification), the need for competent staff who are aware of the company's quality objectives and trained to follow instructions is crucial. Mastering sanitary quality is only possible if matched with a programme to build the skills of companies' human resources. The Pesticide Initiative Programme (PIP), mindful of the importance of making operators autonomous and of training them to monitor EU food safety regulations and technology on their own, has successfully developed a training programme while building a quality network of local/ACP service providers. By building the capacities of ACP experts and then securing their services as trainers, PIP also guarantees companies' access to expertise and the sustainability of their efforts to comply with new EU regulations. The training strategy developed by PIP rests on two pilars: instructor training and collective training. Instructor training consists in reinforcing the technical knowledge of local experts (agronomists, hygienists, etc.) by providing them with active teaching methods. Once the ACP experts have gained enough technical knowledge of the key areas of crop protection--mainly pesticides management--and food safety, and have demonstrated their capacity to train the technical staff of local companies, the PIP has carried out a collective training programme in 2004, 2005 and 2006. To date, more than 130 consultants covering about 15 ACP countries have received instructor training, and more than 700 people have participated in collective and in-company training sessions.

  14. National Niemann-Pick Disease Foundation

    Science.gov (United States)

    ... NIH Posted by jbeirl | RECEIVED FROM THE NIH Gene therapy shows promise for treating Niemann-Pick disease type C1 NIH mouse study... NNPDF Research Request for ASMD Posted by jbeirl | The NNPDF ...

  15. Automatic traveltime picking using instantaneous traveltime

    KAUST Repository

    Saragiotis, Christos

    2013-02-08

    Event picking is used in many steps of seismic processing. We present an automatic event picking method that is based on a new attribute of seismic signals, instantaneous traveltime. The calculation of the instantaneous traveltime consists of two separate but interrelated stages. First, a trace is mapped onto the time-frequency domain. Then the time-frequency representation is mapped back onto the time domain by an appropriate operation. The computed instantaneous traveltime equals the recording time at those instances at which there is a seismic event, a feature that is used to pick the events. We analyzed the concept of the instantaneous traveltime and demonstrated the application of our automatic picking method on dynamite and Vibroseis field data.

  16. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

    Directory of Open Access Journals (Sweden)

    Birgitte Holst

    Full Text Available Secretory vesicles in endocrine cells store hormones such as growth hormone (GH and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN and their subsequent maturation remain unclear. Here, we identify the lipid binding BAR (Bin/amphiphysin/Rvs domain protein PICK1 (protein interacting with C kinase 1 as a key component early in the biogenesis of secretory vesicles in GH-producing cells. Both PICK1-deficient Drosophila and mice displayed somatic growth retardation. Growth retardation was rescued in flies by reintroducing PICK1 in neurosecretory cells producing somatotropic peptides. PICK1-deficient mice were characterized by decreased body weight and length, increased fat accumulation, impaired GH secretion, and decreased storage of GH in the pituitary. Decreased GH storage was supported by electron microscopy showing prominent reduction in secretory vesicle number. Evidence was also obtained for impaired insulin secretion associated with decreased glucose tolerance. PICK1 localized in cells to immature secretory vesicles, and the PICK1 BAR domain was shown by live imaging to associate with vesicles budding from the TGN and to possess membrane-sculpting properties in vitro. In mouse pituitary, PICK1 co-localized with the BAR domain protein ICA69, and PICK1 deficiency abolished ICA69 protein expression. In the Drosophila brain, PICK1 and ICA69 co-immunoprecipitated and showed mutually dependent expression. Finally, both in a Drosophila model of type 2 diabetes and in high-fat-diet-induced obese mice, we observed up-regulation of PICK1 mRNA expression. Our findings suggest that PICK1, together with ICA69, is critical during budding of immature secretory vesicles from the TGN and thus for vesicular storage of GH and possibly other hormones. The data link two BAR domain proteins to membrane remodeling processes in the secretory pathway of

  17. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

    Science.gov (United States)

    Holst, Birgitte; Madsen, Kenneth L; Jansen, Anna M; Jin, Chunyu; Rickhag, Mattias; Lund, Viktor K; Jensen, Morten; Bhatia, Vikram; Sørensen, Gunnar; Madsen, Andreas N; Xue, Zhichao; Møller, Siri K; Woldbye, David; Qvortrup, Klaus; Huganir, Richard; Stamou, Dimitrios; Kjærulff, Ole; Gether, Ulrik

    2013-01-01

    Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here, we identify the lipid binding BAR (Bin/amphiphysin/Rvs) domain protein PICK1 (protein interacting with C kinase 1) as a key component early in the biogenesis of secretory vesicles in GH-producing cells. Both PICK1-deficient Drosophila and mice displayed somatic growth retardation. Growth retardation was rescued in flies by reintroducing PICK1 in neurosecretory cells producing somatotropic peptides. PICK1-deficient mice were characterized by decreased body weight and length, increased fat accumulation, impaired GH secretion, and decreased storage of GH in the pituitary. Decreased GH storage was supported by electron microscopy showing prominent reduction in secretory vesicle number. Evidence was also obtained for impaired insulin secretion associated with decreased glucose tolerance. PICK1 localized in cells to immature secretory vesicles, and the PICK1 BAR domain was shown by live imaging to associate with vesicles budding from the TGN and to possess membrane-sculpting properties in vitro. In mouse pituitary, PICK1 co-localized with the BAR domain protein ICA69, and PICK1 deficiency abolished ICA69 protein expression. In the Drosophila brain, PICK1 and ICA69 co-immunoprecipitated and showed mutually dependent expression. Finally, both in a Drosophila model of type 2 diabetes and in high-fat-diet-induced obese mice, we observed up-regulation of PICK1 mRNA expression. Our findings suggest that PICK1, together with ICA69, is critical during budding of immature secretory vesicles from the TGN and thus for vesicular storage of GH and possibly other hormones. The data link two BAR domain proteins to membrane remodeling processes in the secretory pathway of peptidergic endocrine

  18. Picking among pen-reared quail

    Science.gov (United States)

    Nestler, R.B.; Coburn, D.R.; Titus, H.W.

    1945-01-01

    During five years (1939-43) of nutritional research on pen-reared bobwhite quail at the Patuxent Research Refuge, Bowie, Maryland, observations on picking among birds of all ages showed the following results: 1. Picking occurred on all grains tested: corn, wheat, oats, oat groats, barley, millet, buckwheat, kaffir, and mixtures of cereals. The lowest incidence was with buckwheat as the sole grain in a growing diet....2. Picking occurred on all levels of fiber from one to 11per cent in a growing diet....3. Picking occurred on various grinds of corn, barley, and oats, but was least when these cereals were ground in a hammer mill with 3/32 inch mesh screen....4. The incidence was as high on diets containing animal protein as on those containing no animal protein. ....5. After picking began, the addition of one or two per cent of salt to the diet for several days was effective, in many instances, in checking the disorder. Results at the Refuge and the answers to questionnaires from 222 private propagators of gamebirds showed that in two-thirds. of the cases, treatment with an increased quantity of salt successfully stopped the trouble. As a preventative, however, salt was of little value. Picking occurred on both low and high levels of salt.....6. Supplementing the regular diet with certain feed concentrates such as fishmeal, soybean oil meal, liver meal, or chopped greens offered in a separate feeder for a day or two, was as efficacious as the addition of salt.....7. More picking occurred among quail chicks on a 22 per cent level of protein than on higher levels.....8. There was less picking on diets relished by the birds than on those seemingly unpalatable.....9. There was no correlation. between the amount of floor space per chick and the incidence of picking.....10. Increasing the feeding and drinking space seemed to have a marked beneficial effect.....11. Some adult birds on wire floors resorted to self-picking of their feet after the toes were frost-bitten.

  19. Automatic onset phase picking for portable seismic array observation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Automatic phase picking is a critical procedure for seismic data processing, especially for a huge amount of seismic data recorded by a large-scale portable seismic array. In this study is presented a new method used for automatic accurate onset phase picking based on the property of dense seismic array observations. In our method, the Akaike's information criterion (AIC) for the single channel observation and the least-squares cross-correlation for the multi-channel observation are combined together. The tests by the seismic array observation data after triggering with the short-term average/long-term average (STA/LTA) technique show that the phase picking error is less than 0.3 s for local events by using the single channel AIC algorithm. In terms of multi-channel least-squares cross-correlation technique, the clear teleseismic P onset can be detected reliably. Even for the teleseismic records with high noise level, our algorithm is also able to effectually avoid manual misdetections.

  20. Picking the right transition strategy.

    Science.gov (United States)

    Watkins, Michael D

    2009-01-01

    Leaders in transition reflexively rely on the skills and strategies that worked for them in the past. That's a mistake, says Watkins, whose research shows that executives moving into new roles must gain a deep understanding of the situation at hand and adapt to it. To help them accurately assess their organizations and tailor their strategies and styles accordingly, he developed the STARS framework. "STARS" is an acronym for the five common situations leaders move into: start-up, turnaround, accelerated growth, realignment, and sustaining success. Thus, the model outlines the challenges of launching a venture or project; saving a business or initiative that's in serious trouble; dealing with rapid expansion; reenergizing a once-leading company that's now facing problems; and following in the footsteps of a highly regarded leader with a strong legacy of success. Executives can accelerate their immersion in new roles by following certain fundamental principles: Organize to learn about the business, establish A-item priorities, define strategic intent, quickly build the leadership team, secure early wins, and create supportive alliances across the company. But the way those principles should be applied depends very much on the business situation, which the STARS framework can help leaders analyze. Turnarounds and realignments present especially distinct leadership challenges that call for particular transition strategies. Regardless of the business situation, leaders must figure out which things need to happen--perhaps a jump in market share or an expansion into different markets--for their business to achieve its goals. And they must determine which leadership style best fits the new culture they're joining. Armed with such clarity, executives can design effective plans to manage their organizations and themselves.

  1. Performance Approximation and Design of Pick-and-Pass Order Picking Systems

    NARCIS (Netherlands)

    M. Yu (Mengfei); M.B.M. de Koster (René)

    2007-01-01

    textabstractIn this paper, we discuss an approximation method based on G/G/m queuing network modeling using Whitt’s (1983) queuing network analyzer to analyze pick-and-pass order picking systems. The objective of this approximation method is to provide an instrument for obtaining rapid performance

  2. Development of a doorframe-typed swinging seedling pick-up device for automatic field transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Han, H.; Mao, H.; Hu, J.; Tian, K.

    2015-07-01

    A doorframe-typed swing seedling pick-up device for automatic field transplanters was developed and evaluated in a laboratory. The device, consisting of a path manipulator and two grippers, can move the pins slowly to extract seedlings from the tray cells and return quickly to the pick-up point for the next extraction. The path manipulator was constructed with the creative design of type-Ⅱ mechanism combination in series. It consists of an oscillating guide linkage mechanism and a grooved globoidal cam mechanism. The gripper is a pincette-type mechanism using the pick-up pins to penetrate into the root mass for seedling extraction. The dynamic analysis of the designed seedling pick-up device was simulated with ADAMS software. Being the first prototype, various performance tests under local production conditions were conducted to find out the optimal machine operation parameters and transplant production conditions. As the gripper with multiple fine pins was moved by the swing pick-up device, it can effectively complete the transplanting work cycle of extracting, transferring, and discharging a seedling. The laboratory evaluation showed that the pick-up device equipped with two grippers can extract 80 seedlings/min with a 90% success and a 3% failure in discharging seedlings, using 42-day-old tomato plantlets. The quality of extracting seedlings was satisfactory. (Author)

  3. Development of a doorframe-typed swinging seedling pick-up device for automatic field transplantation

    Directory of Open Access Journals (Sweden)

    Han Luhua

    2015-06-01

    Full Text Available A doorframe-typed swing seedling pick-up device for automatic field transplanters was developed and evaluated in a laboratory. The device, consisting of a path manipulator and two grippers, can move the pins slowly to extract seedlings from the tray cells and return quickly to the pick-up point for the next extraction. The path manipulator was constructed with the creative design of type-II mechanism combination in series. It consists of an oscillating guide linkage mechanism and a grooved globoidal cam mechanism. The gripper is a pincette-type mechanism using the pick-up pins to penetrate into the root mass for seedling extraction. The dynamic analysis of the designed seedling pick-up device was simulated with ADAMS software. Being the first prototype, various performance tests under local production conditions were conducted to find out the optimal machine operation parameters and transplant production conditions. As the gripper with multiple fine pins was moved by the swing pick-up device, it can effectively complete the transplanting work cycle of extracting, transferring, and discharging a seedling. The laboratory evaluation showed that the pick-up device equipped with two grippers can extract 80 seedlings/min with a 90% success and a 3% failure in discharging seedlings, using 42-day-old tomato plantlets. The quality of extracting seedlings was satisfactory.

  4. Bayesian peak picking for NMR spectra.

    Science.gov (United States)

    Cheng, Yichen; Gao, Xin; Liang, Faming

    2014-02-01

    Protein structure determination is a very important topic in structural genomics, which helps people to understand varieties of biological functions such as protein-protein interactions, protein-DNA interactions and so on. Nowadays, nuclear magnetic resonance (NMR) has often been used to determine the three-dimensional structures of protein in vivo. This study aims to automate the peak picking step, the most important and tricky step in NMR structure determination. We propose to model the NMR spectrum by a mixture of bivariate Gaussian densities and use the stochastic approximation Monte Carlo algorithm as the computational tool to solve the problem. Under the Bayesian framework, the peak picking problem is casted as a variable selection problem. The proposed method can automatically distinguish true peaks from false ones without preprocessing the data. To the best of our knowledge, this is the first effort in the literature that tackles the peak picking problem for NMR spectrum data using Bayesian method.

  5. Bayesian Peak Picking for NMR Spectra

    KAUST Repository

    Cheng, Yichen

    2014-02-01

    Protein structure determination is a very important topic in structural genomics, which helps people to understand varieties of biological functions such as protein-protein interactions, protein–DNA interactions and so on. Nowadays, nuclear magnetic resonance (NMR) has often been used to determine the three-dimensional structures of protein in vivo. This study aims to automate the peak picking step, the most important and tricky step in NMR structure determination. We propose to model the NMR spectrum by a mixture of bivariate Gaussian densities and use the stochastic approximation Monte Carlo algorithm as the computational tool to solve the problem. Under the Bayesian framework, the peak picking problem is casted as a variable selection problem. The proposed method can automatically distinguish true peaks from false ones without preprocessing the data. To the best of our knowledge, this is the first effort in the literature that tackles the peak picking problem for NMR spectrum data using Bayesian method.

  6. Pick matricies and quaternionic power series

    OpenAIRE

    Bolotnikov, Vladimir

    2014-01-01

    It is well known that a non-constant complex-valued function $f$ defined on the open unit disk $\\mathbb D$ is an analytic self-mapping of $\\D$ if and only if Pick matrices $\\left[ (1-f(z_i)\\overline{f(z_j)})/(1-z_i\\overline{z}_j)\\right]_{i,j=1}^n$ are positive semidefinite for all choices of finitely many points $z_i\\in\\D$. A stronger version of the "if" part was established by Alan Hindmarsh: if all $3\\times 3$ Pick matrices are positive semidefinite, then $f$ is an analytic self-mapping of ...

  7. Intelligent Control Mechanism of Part Picking Operations of Automated Warehouse

    Institute of Scientific and Technical Information of China (English)

    Chwen-Tzeng; Su

    2002-01-01

    This paper studies the part picking operations of a ut omated warehouse. It assumed the demand of picking orders of automated warehouse are dynamic generated. Once the picking orders of certain period of time are kn own, it is necessary to decide an efficient order picking sequence and routing t o minimize the total travel distance to complete those orders. Assumed there are n i items to be picked in order O i. Each item in the picking ord er is located in different locations in the warehouse. Since i...

  8. Radon in homes of the Portland, Oregon Area: Radon data from local radon testing companies collected by CRM (Continuous Radon Measurement) machines

    Science.gov (United States)

    Whitney, H.; Lindsey, K.; Linde, T.; Burns, S. F.

    2013-12-01

    Students from the Department of Geology at Portland State University paired up with the Oregon Health Authority to better understand radon gas values in homes of the Portland metropolitan area. This study focuses on radon values collected by continuous radon measurement (CRM) machines, taken by local radon testing companies. The local companies participating in this study include Alpha Environmental Services, Inc., Cascade Radon, Environmental Works, The House Detectives, LLC, and Soil Solutions Environmental Services, Inc. In total, 2491 radon readings spanning across 77 zip codes were collected from local companies in the Portland metropolitan area. The maximum value, average value, percentage of homes greater than 4 pCi/L and total rank sum was calculated and used to determine the overall radon potential for each zip code (Burns et al., 1998). A list and four maps were produced showing the results from each category. Out of the total records, 24 zip codes resulted in high radon potential and the average reading for the entire Portland Metropolitan area was 3.7 pCi/L. High potential zip codes are thought to be a result of sand and gravel (Missoula Flood deposits) and faults present in the subsurface. The CRM data was compared with both long-term and short-term data provided by the Oregon Health Authority to validate radon potentials in each zip code. If a home is located in a zip code with high or moderate radon potential across two types of data sets, it is recommended that those homes be tested for radon gas.

  9. Foreign Friends Join Spring Tea Picking

    Institute of Scientific and Technical Information of China (English)

    Rong; You

    2013-01-01

    <正>Foreign Friends Picking Spring Tea, one of the activities of the Fourth China Tea Festival, was held in Pujiang County, Sichuan Province on March 17. Pang Te Cheng, Singaporean Consul General in Chengdu, Komate Kamalanavin, Thai Consul General in Chengdu, and Claudia Spahl, German

  10. Fast visual part inspection for bin picking

    DEFF Research Database (Denmark)

    Rofalis, Nikolaos; Olesen, Anders Sig; Jakobsen, Michael Linde

    2016-01-01

    In this paper we present a novel 3D sensing approach for industrial bin-picking applications that is low-cost, fast and precise. The system uses a simple laser-line emitter. While a robot arm moves the object through the laser light, a synchronized camera captures the laser line image on the object...

  11. Genetics Home Reference: Niemann-Pick disease

    Science.gov (United States)

    ... causing this fat to accumulate in cells. This fat buildup causes cells to malfunction and eventually die. Over time, cell loss impairs function of tissues and organs including the brain, lungs, spleen, and liver in people with Niemann-Pick disease types A and B. Mutations in either the NPC1 ...

  12. Cloud Computing:A Perfect Fit for Midsized Companies

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ I often hear a debate about exactly who is using cloud computing--especially the IaaS variant.Many times I hear people aver that cloud computing is mostly being used by SMB companies.Others assert that cloud computing will really pick up when really large companies make the move.

  13. 7 CFR 51.1315 - Carefully hand-picked.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Carefully hand-picked. 51.1315 Section 51.1315... STANDARDS) United States Standards for Winter Pears 1 Definitions § 51.1315 Carefully hand-picked. Carefully hand-picked means that the pears do not show evidence of rough handling or of having been on the ground....

  14. 7 CFR 51.1274 - Carefully hand-picked.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Carefully hand-picked. 51.1274 Section 51.1274... STANDARDS) United States Standards for Summer and Fall Pears 1 Definitions § 51.1274 Carefully hand-picked. Carefully hand-picked means that the pears do not show evidence of rough handling or of having been on...

  15. Design and Control of Warehouse Order Picking: a literature review

    NARCIS (Netherlands)

    M.B.M. de Koster (René); T. Le-Duc (Tho); K.J. Roodbergen (Kees-Jan)

    2006-01-01

    textabstractOrder picking has long been identified as the most labour-intensive and costly activity for almost every warehouse; the cost of order picking is estimated to be as much as 55% of the total warehouse operating expense. Any underperformance in order picking can lead to unsatisfactory servi

  16. Complete Pick Positivity and Unitary Invariance

    CERN Document Server

    Bhattacharya, Angshuman

    2009-01-01

    The characteristic function for a contraction is a classical complete unitary invariant devised by Sz.-Nagy and Foias. Just as a contraction is related to the Szego kernel $k_S(z,w) = (1 - z\\ow)^{-1}$ for $|z|, |w| < 1$, by means of $(1/k_S)(T,T^*) \\ge 0$, we consider an arbitrary open connected domain $\\Omega$ in $\\BC^n$, a complete Nevanilinna-Pick kernel $k$ on $\\Omega$ and a tuple $T = (T_1, ..., T_n)$ of commuting bounded operators on a complex separable Hilbert space $\\clh$ such that $(1/k)(T,T^*) \\ge 0$. For a complete Pick kernel the $1/k$ functional calculus makes sense in a beautiful way. It turns out that the model theory works very well and a characteristic function can be associated with $T$. Moreover, the characteristic function then is a complete unitary invariant for a suitable class of tuples $T$.

  17. Stem Cells in Niemann-Pick Disease

    Directory of Open Access Journals (Sweden)

    Sun-Jung Kim

    2008-01-01

    Full Text Available Neural stem cells are multi-potent and able to self renew to maintain its character throughout the life. Loss of self renewal ability of stem cells prevents recovery or replacement of cells damaged by disease with new cells. The Niemann-Pick type C1 (NPC1 disease is one of the neurodegenerative diseases, caused by a mutation of NPC1 gene which affects the function of NPC1 protein. We reported that NPC 1 gene deficiency could lead to lack of the self renewal ability of neural stem cells in Niemann pick type C disease. We also investigated many genes which are involved in stem cells proliferation and differentiation by gene profile in NPC mice.

  18. Niemann-Pick disease type C

    OpenAIRE

    Vanier Marie T

    2010-01-01

    Abstract Niemann-Pick C disease (NP-C) is a neurovisceral atypical lysosomal lipid storage disorder with an estimated minimal incidence of 1/120 000 live births. The broad clinical spectrum ranges from a neonatal rapidly fatal disorder to an adult-onset chronic neurodegenerative disease. The neurological involvement defines the disease severity in most patients but is typically preceded by systemic signs (cholestatic jaundice in the neonatal period or isolated spleno- or hepatosplenomegaly in...

  19. Study on Picking Single Micro Uranium Particles

    Institute of Scientific and Technical Information of China (English)

    WANG; Fan; ZHANG; Yan; ZHAO; Yong-gang; LU; Jie

    2012-01-01

    <正>From isotopic ratio of a single particle, plenty of information can be inferred, such as its forming process, origin and so on. These information are essential and wildly used for nuclear safeguards, nuclear forensic and geology. To evaluate the capability of the measurement of isotopic ratio in individual particle by secondary ion mass spectrometry, particles of five different diameters (1, 5, 10, 20, 50 μm) were picked by micromanipulator system.

  20. Warehouse Order-Picking Process. Review

    Directory of Open Access Journals (Sweden)

    E. V. Korobkov

    2015-01-01

    Full Text Available This article describes basic warehousing activities, namely: movement, information storage and transfer, as well as connections between typical warehouse operations (reception, transfer, assigning storage position and put-away, order-picking, hoarding and sorting, cross-docking, shipping. It presents a classification of the warehouse order-picking systems in terms of manual labor on offer as well as external (marketing channels, consumer’s demand structure, supplier’s replenishment structure and inventory level, total production demand, economic situation and internal (mechanization level, information accessibility, warehouse dimensionality, method of dispatch for shipping, zoning, batching, storage assignment method, routing method factors affecting the designing systems complexity. Basic optimization considerations are described. There is a literature review on the following sub-problems of planning and control of orderpicking processes.A layout design problem has been taken in account at two levels — external (facility layout problem and internal (aisle configuration problem. For a problem of distributing goods or stock keeping units the following methods are emphasized: random, nearest open storage position, and dedicated (COI-based, frequency-based distribution, as well as class-based and familygrouped (complimentary- and contact-based one. Batching problem can be solved by two main methods, i.e. proximity order batching (seed and saving algorithms and time-window order batching. There are two strategies for a zoning problem: progressive and synchronized, and also a special case of zoning — bucket brigades method. Hoarding/sorting problem is briefly reviewed. Order-picking routing problem will be thoroughly described in the next article of the cycle “Warehouse order-picking process”.

  1. Ion pick-up near the icy Galilean satellites

    Science.gov (United States)

    Volwerk, M.; Khurana, K. K.

    2010-12-01

    The ion pick-up near the icy Galilean satellites is studied using ion cyclotron waves. Using Galileo magnetometer data, we show evidence for the existence of ion cyclotron waves, which are generated by pick-up of freshly ionized particles. Near Europa, in the wake various kinds of ions are detected, which were already predicted to be present on the moon. Upstream of the moon there is evidence for water ion pick-up, which could facilitate the slow down of the plasma flow. Ganymede shows evidence for either water or oxygen pick up on the flanks of the magnetosphere. Callisto shows indication of hydrogen pick-up from its atmosphere.

  2. COOPERATION WITH ASSETS MANAGEMENT COMPANIES AS THE INVESTMENT ACTIVITY OF INSURANCE COMPANIES

    OpenAIRE

    2008-01-01

    The article explores the peculiarities of investment activity of local insurance companies there is analyze of one of the option using the investment opportunities of insurance companies in the way of cooperation with assets management companies.

  3. Research of Personnel Localization of Our Overseas Companies%我国境外企业人员当地化研究

    Institute of Scientific and Technical Information of China (English)

    王小伟; 舒清; 王佳

    2015-01-01

    Research on our ten years of foreign enterprises overseas investment practice shows personnel localization plays a positive economic and social effects on overseas companies and exhibits such efforts to hire local employees and attention to material incentives and growth of local staff as characteristics.At the same time, there have been some problems, for example, the weaker recognition for the enterprise culture of the lo-cal staff, the“glass ceiling effect” and the higher turnover rate.Therefore, this paper proposes some solutions including constructing international corporate culture , expanding the scale of recruitment, holding related training and learning, optimizing combination of salaries and benefits, accelerating promotion and so on.%我国境外企业十多年的境外投资实践表明,人员当地化为境外企业自身带来了积极的经济和社会效应。然而,在出当地员工聘用力度增大、重视当地员工的物质激励和成长学习的同时,这些企业也存在当地员工对企业文化的认同感不强、“玻璃天花板效应”及离职率较高等问题。对此,提出了解决的对策,包括营建国际化管理的企业文化、扩大招聘规模、开展培训与学习、优化薪酬福利组合、加速晋升通道等。

  4. Cold pressor pain in skin picking disorder.

    Science.gov (United States)

    Grant, Jon E; Redden, Sarah A; Chamberlain, Samuel R

    2017-03-01

    Excoriation (skin-picking) disorder (SPD) is a disabling, under-recognized condition in which individuals repeatedly pick at their skin, leading to noticeable tissue damage. There has been no examination as to whether individuals with SPD have different pain thresholds or pain tolerances compared to healthy counterparts. Adults with SPD were examined on a variety of clinical measures including symptom severity and functioning. All participants underwent the cold pressor test. Heart rate, blood pressure, and self-reported pain were compared between SPD participants (n=14) and healthy controls (n=14). Adults with SPD demonstrated significantly dampened autonomic response to cold pressor pain as exhibited by reduced heart rate compared to controls (group x time interaction using repeated ANOVA F=3.258, p<0.001). There were no significant differences between the groups in terms of overall pain tolerance (measured in seconds), recovery time, or blood pressure. SPD symptom severity was not significantly associated with autonomic response in the patients. In this study, adults with SPD exhibited a dampened autonomic response to pain while reporting pain intensity similar to that reported by the controls. The lack of an autonomic response may explain why the SPD participants continue a behavior that they cognitively find painful and may offer options for future interventions.

  5. 含义丰富的Pick up

    Institute of Scientific and Technical Information of China (English)

    刘奉越

    2004-01-01

    在我们的课本中,有这么一个句子:Have you ever picked up a library book?在这里pick up意为“捡到”。在不同的语言环境里,pick up可表示不同的含义,本文就其用法和含义作一归纳。

  6. Reestructuración del layout de la zona de picking en una bodega industrial

    Directory of Open Access Journals (Sweden)

    Martín Darío Arango Serna

    2010-12-01

    Full Text Available Este artículo tiene como objetivo presentar una propuesta orientada al mejoramiento de los procesos de distribución y Picking en la bodega de una empresa del sector industrial. Este presenta, inicialmente el marco teórico y la problemática, finaliza con la presentación del caso empresarial objeto de estudio. Las actividades relacionadas con el almacenamiento de materiales son de las que más interfieren en los costos logísticos totales en una empresa o cadena de suministro. Una de las actividades primordiales para intentar reducir los costos operativos es la optimización de los espacios requeridos en el almacenamiento. La finalidad del estudio radica principalmente en la disminución de los tiempos de preparación de pedido para lograr una mejora en el servicio y en la reducción del área destinada al almacenamiento para mitigar los costos de operación. / The main objective of this paper is to present a proposal aimed at improving the distribution and picking processes in a warehouse of an industrial company. Initially, it outlines the theory and problem to be solved, and concludes with a description of a case study. Warehousing activities affect the total logistics costs of a company or supply chain most; thus, optimizing the required spaces for warehousing is one of the most important activities when attempting to reduce operative costs in a company. The purpose of this study is to reduce the time required for picking activities and, therefore, obtain an improvement in the service and a reduction of the area used in the warehouse, which leads to cost reductions.

  7. 解读pick up的各种意义

    Institute of Scientific and Technical Information of China (English)

    陈锁兆

    2007-01-01

    <正>本文旨在解读pick up的各种意义。1.pick up最基本的含义是“拾起;捡起;拿起”。例如:The Young Pioneer turned over to the police the wallet he had picked up in the street.那位少先队员把他在街上拾到的钱包交给了警察。Having played for a while,the boys picked up their school bags from

  8. Exact Solutions to the Symmetric and Asymmetric Vehicle Routing Problem with Simultaneous Delivery and Pick-Up

    Directory of Open Access Journals (Sweden)

    Julia Rieck

    2013-05-01

    Full Text Available In reverse logistics networks, products (e.g., bottles or containers have to be transported from a depot to customer locations and, after use, from customer locations back to the depot. In order to operate economically beneficial, companies prefer a simultaneous delivery and pick-up service. The resulting Vehicle Routing Problem with Simultaneous Delivery and Pick-up (VRPSDP is an operational problem, which has to be solved daily by many companies. We present two mixed-integer linear model formulations for the VRPSDP, namely a vehicle-flow and a commodity-flow model. In order to strengthen the models, domain-reducing preprocessing techniques, and effective cutting planes are outlined. Symmetric benchmark instances known from the literature as well as new asymmetric instances derived from real-world problems are solved to optimality using CPLEX 12.1.

  9. Excoriation (skin-picking) disorder in adults

    DEFF Research Database (Denmark)

    Leibovici, Vera; Koran, Lorrin M; Murad, Sari

    2015-01-01

    OBJECTIVE: We sought to estimate the lifetime prevalence of Excoriation (Skin-Picking) Disorder (SPD) in the Israeli adult population as a whole and compare SPD prevalence in the Jewish and Arab communities. We also explored demographic, medical and psychological correlates of SPD diagnosis....... METHODS: Questionnaires and scales screening for SPD, and assessing the severity of perceived stress, depression, obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), alcohol use, illicit drug use, and medical disorders were completed in a sample of 2145 adults attending medical settings...... was more prevalent in the SPD-positive Jewish subsample (p=0.02). In the total sample, diabetes mellitus was more common in women than in men (p=0.04). CONCLUSION: Lifetime SPD appears to be relatively common in Israeli adults and associated with other mental disorders. Differences in the self...

  10. Company analysis

    DEFF Research Database (Denmark)

    Jenster, Per V.; Hussey, David

    This volume looks at the company appraisal as a whole, examining the continuing need to appraise companies as part of the continuing strategy process. Building from a sound basis of theory, the text aims to be practical and to give guidance to senior managers and others involved in the strategy p...

  11. System for conveyor belt part picking using structured light and 3D pose estimation

    Science.gov (United States)

    Thielemann, J.; Skotheim, Ø.; Nygaard, J. O.; Vollset, T.

    2009-01-01

    Automatic picking of parts is an important challenge to solve within factory automation, because it can remove tedious manual work and save labor costs. One such application involves parts that arrive with random position and orientation on a conveyor belt. The parts should be picked off the conveyor belt and placed systematically into bins. We describe a system that consists of a structured light instrument for capturing 3D data and robust methods for aligning an input 3D template with a 3D image of the scene. The method uses general and robust pre-processing steps based on geometric primitives that allow the well-known Iterative Closest Point algorithm to converge quickly and robustly to the correct solution. The method has been demonstrated for localization of car parts with random position and orientation. We believe that the method is applicable for a wide range of industrial automation problems where precise localization of 3D objects in a scene is needed.

  12. Skin Picking in Turkish Students: Prevalence, Characteristics, and Gender Differences

    Science.gov (United States)

    Calikusu, Celal; Kucukgoncu, Suat; Tecer, Ozlem; Bestepe, Emrem

    2012-01-01

    The aim of this study is to investigate the prevalence, characteristics, triggers, and consequences of skin picking (SP) in a sample of Turkish university students, with an emphasis on gender differences. A total of 245 students from two universities in Turkey were assessed by using the Skin Picking Inventory. In total, 87.8% of the students…

  13. Skin Picking in Turkish Students: Prevalence, Characteristics, and Gender Differences

    Science.gov (United States)

    Calikusu, Celal; Kucukgoncu, Suat; Tecer, Ozlem; Bestepe, Emrem

    2012-01-01

    The aim of this study is to investigate the prevalence, characteristics, triggers, and consequences of skin picking (SP) in a sample of Turkish university students, with an emphasis on gender differences. A total of 245 students from two universities in Turkey were assessed by using the Skin Picking Inventory. In total, 87.8% of the students…

  14. The ACRV Picking Benchmark (APB): A Robotic Shelf Picking Benchmark to Foster Reproducible Research

    OpenAIRE

    Leitner, Jürgen; Tow, Adam W.; Dean, Jake E.; Suenderhauf, Niko; Durham, Joseph W.; Cooper, Matthew; Eich, Markus; Lehnert, Christopher; Mangels, Ruben; McCool, Christopher; Kujala, Peter; Nicholson, Lachlan; Van Pham, Trung; Sergeant, James; Wu, Liao

    2016-01-01

    Robotic challenges like the Amazon Picking Challenge (APC) or the DARPA Challenges are an established and important way to drive scientific progress. They make research comparable on a well-defined benchmark with equal test conditions for all participants. However, such challenge events occur only occasionally, are limited to a small number of contestants, and the test conditions are very difficult to replicate after the main event. We present a new physical benchmark challenge for robotic pi...

  15. Membrane Binding and Modulation of the PDZ Domain of PICK1

    DEFF Research Database (Denmark)

    Erlendsson, Simon; Madsen, Kenneth Lindegaard

    2015-01-01

    Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of b...... lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function....

  16. Nonmedical factors associated with feather picking in pet psittacine birds.

    Science.gov (United States)

    Gaskins, Lori A; Hungerford, Laura

    2014-06-01

    A nested case-control study was performed to determine nonmedical risk factors associated with feather picking in psittacine birds. Forty-two case birds, reported by their owners to pick their feathers, and 126 unaffected birds were compared. The odds of feather picking were higher in 2 species categories, African grey parrots (Psitticus erithacus, adjusted odds ratio [ORadj = 8.4, P picking also were higher for birds that were out of their cages more than 8 hours per day (ORadj = 7.4, P picking decreased by almost 90% (ORadj = 0.1, P < .005) for birds that interacted with people at least 4 hours a day. These findings identify characteristics that practitioners may want to include when asking bird owners about behavioral history and may be useful in focusing future research regarding this behavior.

  17. The Development of Local Fast-food Franchise Companies in China%中国本土快餐连锁企业发展分析

    Institute of Scientific and Technical Information of China (English)

    侯冬梅; 何鑫

    2012-01-01

    Difficulties facing China's local fast-food franchise companies include serious food safety problems, low price threats from foreign fast food, the block to the development of indigenous markets, and the deficiency of brand recognition and consumer loyalty. To overcome these difficulties, fast-food companies need to prioritize target customers' requirement, envisage the product quality defects, ensure product quality, price reasonably, build networks of diversified channels, take advantage of the power of the strong, and improve marketing projects by means of advertisements and public relation strategies. In addition, they need to select strategies suitable to their own conditions, refine the target markets and the products with proper detail management, learn from and utilize the power of the strong to promote themselves on the giant's shoulders.%中国本土快餐连锁企业的困境主要有:严重的食品安全问题;洋快餐的低价优势构成的威胁;自主市场开发受阻;消费者对品牌认知度和忠诚度的缺失等。快餐连锁企业应以目标顾客的需求为前提,正视产品质量缺陷,保证产品质量。合理调整定价,构建多样化渠道网络建设,学会向强者借势。用广告与公共关系策略打造完美促销攻势。同时,还要结合自身发展状况选用适合自己的策略。将目标市场细化,将产品细化,做好细节管理;在向强者学习的同时还要学会向强者借势。要学会站在巨人的肩膀上推销自己。

  18. Open-label escitalopram treatment for pathological skin picking.

    Science.gov (United States)

    Keuthen, Nancy J; Jameson, Mariko; Loh, Rebecca; Deckersbach, Thilo; Wilhelm, Sabine; Dougherty, Darin D

    2007-09-01

    Pathological skin picking is characterized by dysfunctional, repetitive and excessive manipulation of the skin resulting in noticeable tissue damage. This study sought to assess the effectiveness of escitalopram in treating pathological skin picking. Twenty-nine individuals with pathological skin picking were enrolled in an 18-week, open-label trial of escitalopram. Study measures assessing skin picking severity and impact, anxiety, depression, and quality of life were given at baseline and weeks 2, 4, 6, 10, 14, and 18. The mean maximally tolerated dose was 25.0 mg (standard deviation=8.4). For the 19 study completers, pre-post-treatment analyses revealed significant improvements (Ppicking severity and impact, quality of life, and self-rated anxiety and depression. Completer as well as intent-to-treat analyses indicated that approximately half of the sample satisfied full medication response criteria and one-quarter were partial medication responders. Correlational analyses indicated that changes in depression, anxiety, and quality of life co-occurred with reductions in skin picking severity but not impact. A high percentage of variance in severity, however, remained unexplained. These results suggest that escitalopram can be an effective agent in reducing pathological skin picking. The lack of medication response in a subset of our sample suggests the possibility of pathological skin picking subtypes.

  19. Pick-up, impact, and peeling

    Science.gov (United States)

    Singh, Harmeet; Hanna, James

    We consider a class of problems involving a one-dimensional, inextensible body with a propagating discontinuity (shock) associated with partial contact with a rigid obstacle providing steric, frictional, or adhesive forces. This class includes the pick-up and impact of an axially flowing string or cable, and the peeling of an adhesive tape. The dynamics are derived by applying an action principle to a non-material volume. The resulting boundary conditions provide momentum and energy jump conditions at the shock. These are combined with kinematic conditions on velocities and accelerations to obtain families of steady-state solutions parameterized by the shock velocity and momentum and energy sources. We find relationships between the jump in stress, injection of momentum, and dissipation of energy, which we apply to specific cases, and compare with other results in the literature on chain fountains, falling folded chains, and impulsively loaded cables. Time permitting, we will briefly discuss the possibility of using kinematic conditions and information about accelerating or otherwise unsteady forms of the adjoining bulk solutions to construct an equation of motion of the shock.

  20. Comments on R·Frost’s After Apple-Picking

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    Robert Frost once said that a poet“speaks in parables and in hints and inindirections,”for“poetry provides the one permissible way of saying one thingand meaning another.”In After Apple-Picking,one of his best-known poems,Frost again speaks indirectly,in parrables and hints;he is not just talkingabout apple-picking when he says“But I am done with apple-picking now.”What he actually hints is that the“I”(herein indicates the farmer)has justbeen through with his struggle against nature and life.

  1. A morphometric and molecular study of Anastrepha pickeli Lima (Diptera: Tephritidae).

    Science.gov (United States)

    Bomfim, Z V; Lima, K M; Silva, J G; Costa, M A; Zucchi, Robert A

    2011-10-01

    This study investigated the level of morphometric and genetic variability among populations of Anastrepha pickeli Lima from several localities in Brazil, one locality in Bolivia and one in Paraguay. Traditional and geometric morphometric analyses were used, as well as sequencing of a fragment of the cytochrome oxidase gene (COI). Six variables were measured from the aculeus for traditional morphometric analysis and 14 landmarks from the right wing were used for geometric analysis, using 10 specimes/population. The aculeus tip length, aculeus width at the end of the cloaca opening, and the serrate part length contributed with 62.7% for grouping. According to the results from traditional morphometry, there was no significant difference, but the multivariate tests showed that the canonical variables were statistically significant, indicating a difference in the wing conformation among populations. Molecular phylogenetic analysis indicated that the populations clustered into three clades and revealed a high level of genetic variation within A. pickeli populations from various geographic regions. Anastrepha pickeli populations differed among them according to the methods used in this study, showing incongruence among the methods used.

  2. How to pick a good fight.

    Science.gov (United States)

    Joni, Saj-nicole A; Beyer, Damon

    2009-12-01

    Peace and harmony are overrated. Though conflict-free teamwork is often held up as the be-all and end-all of organizational life, it actually can be the worst thing to ever happen to a company. Look at Lehman Brothers. When Dick Fuld took over, he transformed a notoriously contentious workplace into one of Wall Street's most harmonious firms. But his efforts backfired--directors and managers became too agreeable, afraid to rock the boat by pointing out that the firm was heading into a crisis. Research shows that the single greatest predictor of poor company performance is complacency, which is why every organization needs a healthy dose of dissent. Not all kinds of conflict are productive, of course -companies need to find the right balance of alignment and competition and make sure that people's energies are pointed in a positive direction. In this article, two seasoned business advisers lay down ground rules for the right kinds of fights. First, the stakes must be worthwhile: The issue should involve a noble purpose or create noticeable--preferably game-changing--value. Next, good fights focus on the future; they're never about placing blame for the past. And it's critical for leaders to keep fights sportsmanlike, allow informal give-and-take in the trenches, and help soften the blow for the losing parties.

  3. Fast and Reliable Mouse Picking Using Graphics Hardware

    Directory of Open Access Journals (Sweden)

    Hanli Zhao

    2009-01-01

    Full Text Available Mouse picking is the most commonly used intuitive operation to interact with 3D scenes in a variety of 3D graphics applications. High performance for such operation is necessary in order to provide users with fast responses. This paper proposes a fast and reliable mouse picking algorithm using graphics hardware for 3D triangular scenes. Our approach uses a multi-layer rendering algorithm to perform the picking operation in linear time complexity. The objectspace based ray-triangle intersection test is implemented in a highly parallelized geometry shader. After applying the hardware-supported occlusion queries, only a small number of objects (or sub-objects are rendered in subsequent layers, which accelerates the picking efficiency. Experimental results demonstrate the high performance of our novel approach. Due to its simplicity, our algorithm can be easily integrated into existing real-time rendering systems.

  4. Grasp Densities for Grasp Refinement in Industrial Bin Picking

    DEFF Research Database (Denmark)

    Hupfauf, Benedikt; Hahn, Heiko; Bodenhagen, Leon

    Automatic picking of randomly distributed objects from a bin has been denoted the "Holy Grail" in the world of robot automation. A particular property of the bin-picking scenario (in contrast to most other industrial robot applications) is that grasp errors are allowed to occur: Usually bin...... generated in industrial bin-picking for grasp learning. This aim is achieved by using the novel concept of grasp densities (Detry et al., 2010). Grasp densities can describe the full variety of grasps that apply to specific objects using specific grippers. They represent the likelihood of grasp success...... in terms of object-relative gripper pose, can be learned from empirical experience, and allow the automatic choice of optimal grasps in a given scene context (object pose, workspace constraints, etc.). We will show grasp densities extracted from empirical data in a real industrial bin picking context...

  5. Boundary Nevanlinna-pick Interpolation for Meromorphic Functions

    Institute of Scientific and Technical Information of China (English)

    Gong-ning Chen; Li-xin Jia

    2002-01-01

    Versions of the multiple Nevanlinna-Pick interpolation problem in the class N involving both interior and boundary data are investigated. This leads to solvability criteria for the indicated problems and description of their solutions.

  6. Analysis of Pick-Up Development in Punching

    DEFF Research Database (Denmark)

    Olsson, David Dam; Bay, Niels; Andreasen, Jan Lasson

    2002-01-01

    The development of pick-up of work piece material on the punch surface with increasing number of strokes during punching of stainless steel sheet is investigated applying Scanning Electron Microscopy (SEM), 3D roughness mapping and measurements of the backstroke force. It is found that pick......-up on the punch stem develops gradually backwards from the tip of the punch with increasing number of strokes saturating at a certain level while the radial build-up in the case of dry friction conditions continues until the clearance between the punch and die has been filled up. The rate of pick......-up is significantly smaller in case of lubrication and may be very low if an efficient boundary lubricant is applied. Good correlation between the pick-up development and the backstroke force is found....

  7. Automatic Grasp Generation and Improvement for Industrial Bin-Picking

    DEFF Research Database (Denmark)

    Kraft, Dirk; Ellekilde, Lars-Peter; Rytz, Jimmy Alison

    2014-01-01

    This paper presents work on automatic grasp generation and grasp learning for reducing the manual setup time and increase grasp success rates within bin-picking applications. We propose an approach that is able to generate good grasps automatically using a dynamic grasp simulator, a newly developed...... and achieve comparable results and that our learning approach can improve system performance significantly. Automatic bin-picking is an important industrial process that can lead to significant savings and potentially keep production in countries with high labour cost rather than outsourcing it. The presented...... work allows to minimize cycle time as well as setup cost, which are essential factors in automatic bin-picking. It therefore leads to a wider applicability of bin-picking in industry....

  8. Psychosocial dysfunction associated with skin picking disorder and trichotillomania

    DEFF Research Database (Denmark)

    Grant, Jon E.; Redden, Sarah A.; Leppink, Eric W.

    2016-01-01

    Skin picking disorder (SPD) and trichotillomania (TTM) are common and oftentimes disabling disorders. 125 Participants with SPD and 152 with TTM undertook clinical and neurocognitive evaluation, and were grouped according to mild, moderate, or severe levels of psychosocial dysfunction. Relationsh......Skin picking disorder (SPD) and trichotillomania (TTM) are common and oftentimes disabling disorders. 125 Participants with SPD and 152 with TTM undertook clinical and neurocognitive evaluation, and were grouped according to mild, moderate, or severe levels of psychosocial dysfunction...

  9. Automatic first-break picking using the instantaneous traveltime attribute

    KAUST Repository

    Saragiotis, Christos

    2012-01-01

    Picking the first breaks is an important step in seismic processing. The large volume of the seismic data calls for automatic and objective picking. We introduce a new automatic first-break picker, which uses specifically designed time windows and an iterative procedure based on the instantaneous traveltime attribute. The method is fast as it only uses a few FFT\\'s per trace. We demonstrate the effectiveness of this automatic method by applying it on real test data.

  10. Company analysis

    DEFF Research Database (Denmark)

    Jenster, Per V.; Hussey, David

    This volume looks at the company appraisal as a whole, examining the continuing need to appraise companies as part of the continuing strategy process. Building from a sound basis of theory, the text aims to be practical and to give guidance to senior managers and others involved in the strategy...... process. It is thus a book primarily aimed at managers, but should also be useful for MBA students undertaking strategy assignments It provides helpful, practical guidance and identifies weaknesses of traditional methods. It also presents a variety of tools which may be used in the appraisal process...

  11. Bin-picking new approaches for a classical problem

    CERN Document Server

    Buchholz, Dirk

    2016-01-01

    This book is devoted to one of the most famous examples of automation handling tasks – the “bin-picking” problem. To pick up objects, scrambled in a box is an easy task for humans, but its automation is very complex. In this book three different approaches to solve the bin-picking problem are described, showing how modern sensors can be used for efficient bin-picking as well as how classic sensor concepts can be applied for novel bin-picking techniques. 3D point clouds are firstly used as basis, employing the known Random Sample Matching algorithm paired with a very efficient depth map based collision avoidance mechanism resulting in a very robust bin-picking approach. Reducing the complexity of the sensor data, all computations are then done on depth maps. This allows the use of 2D image analysis techniques to fulfill the tasks and results in real time data analysis. Combined with force/torque and acceleration sensors, a near time optimal bin-picking system emerges. Lastly, surface normal maps are empl...

  12. Company profile

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Datacon was founded in 1986 and, since the beginning of 2005, has been part of the Dutch Besi group (BE Semiconductor Industries N.V.), an international group of companies operating in the semiconductor industry. Besi is a leading manufacturer of semiconductor die sorting, die bonding, packaging and plating equipment and provides the most cost efficient solution for RFID inlay production.

  13. Niemann-Pick disease type C

    Directory of Open Access Journals (Sweden)

    Vanier Marie T

    2010-06-01

    Full Text Available Abstract Niemann-Pick C disease (NP-C is a neurovisceral atypical lysosomal lipid storage disorder with an estimated minimal incidence of 1/120 000 live births. The broad clinical spectrum ranges from a neonatal rapidly fatal disorder to an adult-onset chronic neurodegenerative disease. The neurological involvement defines the disease severity in most patients but is typically preceded by systemic signs (cholestatic jaundice in the neonatal period or isolated spleno- or hepatosplenomegaly in infancy or childhood. The first neurological symptoms vary with age of onset: delay in developmental motor milestones (early infantile period, gait problems, falls, clumsiness, cataplexy, school problems (late infantile and juvenile period, and ataxia not unfrequently following initial psychiatric disturbances (adult form. The most characteristic sign is vertical supranuclear gaze palsy. The neurological disorder consists mainly of cerebellar ataxia, dysarthria, dysphagia, and progressive dementia. Cataplexy, seizures and dystonia are other common features. NP-C is transmitted in an autosomal recessive manner and is caused by mutations of either the NPC1 (95% of families or the NPC2 genes. The exact functions of the NPC1 and NPC2 proteins are still unclear. NP-C is currently described as a cellular cholesterol trafficking defect but in the brain, the prominently stored lipids are gangliosides. Clinical examination should include comprehensive neurological and ophthalmological evaluations. The primary laboratory diagnosis requires living skin fibroblasts to demonstrate accumulation of unesterified cholesterol in perinuclear vesicles (lysosomes after staining with filipin. Pronounced abnormalities are observed in about 80% of the cases, mild to moderate alterations in the remainder ("variant" biochemical phenotype. Genotyping of patients is useful to confirm the diagnosis in the latter patients and essential for future prenatal diagnosis. The differential

  14. Niemann-Pick disease type C.

    Science.gov (United States)

    Vanier, Marie T

    2010-06-03

    Niemann-Pick C disease (NP-C) is a neurovisceral atypical lysosomal lipid storage disorder with an estimated minimal incidence of 1/120,000 live births. The broad clinical spectrum ranges from a neonatal rapidly fatal disorder to an adult-onset chronic neurodegenerative disease. The neurological involvement defines the disease severity in most patients but is typically preceded by systemic signs (cholestatic jaundice in the neonatal period or isolated spleno- or hepatosplenomegaly in infancy or childhood). The first neurological symptoms vary with age of onset: delay in developmental motor milestones (early infantile period), gait problems, falls, clumsiness, cataplexy, school problems (late infantile and juvenile period), and ataxia not unfrequently following initial psychiatric disturbances (adult form). The most characteristic sign is vertical supranuclear gaze palsy. The neurological disorder consists mainly of cerebellar ataxia, dysarthria, dysphagia, and progressive dementia. Cataplexy, seizures and dystonia are other common features. NP-C is transmitted in an autosomal recessive manner and is caused by mutations of either the NPC1 (95% of families) or the NPC2 genes. The exact functions of the NPC1 and NPC2 proteins are still unclear. NP-C is currently described as a cellular cholesterol trafficking defect but in the brain, the prominently stored lipids are gangliosides. Clinical examination should include comprehensive neurological and ophthalmological evaluations. The primary laboratory diagnosis requires living skin fibroblasts to demonstrate accumulation of unesterified cholesterol in perinuclear vesicles (lysosomes) after staining with filipin. Pronounced abnormalities are observed in about 80% of the cases, mild to moderate alterations in the remainder ("variant" biochemical phenotype). Genotyping of patients is useful to confirm the diagnosis in the latter patients and essential for future prenatal diagnosis. The differential diagnosis may include

  15. The relationship of psychological trauma with trichotillomania and skin picking

    Directory of Open Access Journals (Sweden)

    Özten E

    2015-05-01

    Full Text Available Eylem Özten,1 Gökben Hızlı Sayar,1 Gül Eryilmaz,1 Gaye Kağan,2 Sibel Işik,3 Oğuz Karamustafalioğlu4 1Neuropsychiatry Health, Practice, and Research Center, Üsküdar University, 2Istanbul Neuropsychiatry Hospital, Üsküdar University, 3Turkish Red Crescent Altintepe Medical Center, 4Department of Psychology, Faculty of Human and Social Sciences, Üsküdar University, Istanbul, Turkey Objective: Interactions between psychological, biological and environmental factors are important in development of trichotillomania and skin picking. The aim of this study is to determine the relationship of traumatic life events, symptoms of post-traumatic stress disorder and dissociation in patients with diagnoses of trichotillomania and skin picking disorder.Methods: The study included patients who was diagnosed with trichotillomania (n=23 or skin picking disorder (n=44, and healthy controls (n=37. Beck Depression Inventory, Traumatic Stress Symptoms Scale and Dissociative Experiences Scale were administered. All groups checked a list of traumatic life events to determine the exposed traumatic events.Results: There was no statistical significance between three groups in terms of Dissociative Experiences Scale scores (P=0.07. But Beck Depression Inventory and Traumatic Stress Symptoms Scale scores of trichotillomania and skin picking groups were significantly higher than the control group. Subjects with a diagnosis of trichotillomania and skin picking reported statistically significantly higher numbers of traumatic and negative events in childhood compared to healthy subjects.Conclusion: We can conclude that trauma may play a role in development of both trichotillomania and skin picking. Increased duration of trichotillomania or skin picking was correlated with decreased presence of post-traumatic stress symptoms. The reason for the negatively correlation of severity of post-traumatic stress symptoms and self-harming behavior may be speculated as

  16. Indoor Radon Gas Management For Multi-Site Companies: How To Screen For Potentially High-Risk Sites By Studying The Local Geology

    Science.gov (United States)

    Ruggeri, Rudi; Gigliuto, Andrea; Minnei, Tiziana; Savini, Raffaella

    2008-08-01

    In this article, ENSR presents an evaluation tool for Radon gas monitoring programs that companies with large portfolios of properties will find useful in reducing their efforts and expenditures. The World Health Organization (WHO) considers Radon gas the second cause of lung cancer and the first source of natural radiations affecting the human population. In Italy, Legal Decree No. 230 (0/17/95) is the laws that regulate gas Radon concentrations in work places. Hereunder we present the ENSR approach to executing preliminary geologic studies aimed at planning an instrumental monitoring program for companies.

  17. Excessive Picking in Prader-Willi Syndrome: A Pilot Study of Phenomenological Aspects and Comorbid Symptoms.

    Science.gov (United States)

    Wigren, Margareta; Heimann, Mikael

    2001-01-01

    Interviews with parents of 37 individuals (ages 12-30) with Prader-Willi syndrome revealed two-thirds displayed skin picking with a frequency ranging from chronic to transient, episodic symptoms. Many individuals with skin picking also exhibited comorbid picking behaviors And individuals with excessive skin picking also had frequent tantrums and…

  18. local

    Directory of Open Access Journals (Sweden)

    Abílio Amiguinho

    2005-01-01

    Full Text Available The process of socio-educational territorialisation in rural contexts is the topic of this text. The theme corresponds to a challenge to address it having as main axis of discussion either the problem of social exclusion or that of local development. The reasons to locate the discussion in this last field of analysis are discussed in the first part of the text. Theoretical and political reasons are there articulated because the question is about projects whose intentions and practices call for the political both in the theoretical debate and in the choices that anticipate intervention. From research conducted for several years, I use contributions that aim at discuss and enlighten how school can be a potential locus of local development. Its identification and recognition as local institution (either because of those that work and live in it or because of those that act in the surrounding context are crucial steps to progressively constitute school as a partner for development. The promotion of the local values and roots, the reconstruction of socio-personal and local identities, the production of sociabilities and the equation and solution of shared problems were the dimensions of a socio-educative intervention, markedly globalising. This scenario, as it is argued, was also, intentionally, one of transformation and of deliberate change of school and of the administration of the educative territoires.

  19. Enhancement of the automatic onset time picking via wavelet thresholding

    Science.gov (United States)

    Gaci, Said

    2013-04-01

    Since arrival time-picking is a critical step in the analysis of geophysical data, many time picking algorithms have been developed. Nowadays, the ''short-time-average through long-time-average trigger'' (STA/LTA) in different forms are the most commonly used. This study aims at improving this algorithm in the presence of high amplitude noise. The suggested method consists of denoising the seismic trace using the discrete wavelet transform. Therefore, the STA/LTA curve obtained from the denoised trace displays a faster build up at the position of the wave arrival, and the picking error is reduced. The application of this technique is first demonstrated on synthetic seismic traces with varying noise levels, then extended to uphole seismic traces recorded in the Algerian Sahara. The results show that the picked first arrivals are more accurate than those yielded by the standard STA/LTA algorithm and this method can tolerate high noise levels. Keywords: picking, first arrival, seismic wave, wavelet thresholding.

  20. Natural gas annual 1993 supplement: Company profiles

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. This report, the Natural Gas Annual 1993 Supplement: Company Profiles, presents a detailed profile of 45 selected companies in the natural gas industry. The purpose of this report is to show the movement of natural gas through the various States served by the companies profiled. The companies in this report are interstate pipeline companies or local distribution companies (LDC`s). Interstate pipeline companies acquire gas supplies from company owned production, purchases from producers, and receipts for transportation for account of others. Pipeline systems, service area maps, company supply and disposition data are presented.

  1. Logistics process improvement of warehousing and picking in a colombian company textile sector

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo-Díaz

    2014-01-01

    Full Text Available Esta investigación considera el problema de diseño de centros de distribución y preparación de pedidos o alistamiento, en una empresa del sector textil colombiano. Mediante una revisión literaria se establece la metodología para el diseño del centro que mejor se ajusta a la empresa para minimizar el tiempo de alistamiento. A partir de la metodología seleccionada se construye el perfil de los pedidos, con base en la caracterización, se trata de manera integral el problema de diseño y alistamiento. Se evalúan distintos escenario de diseño del centro de distribución y políticas de alistamiento y de ruteo, con el propósito de identificar la influencia de los escenarios y políticas en el tiempo de alistamiento de pedidos y el factor de utilización de los recursos involucrados en el proceso. Los resultados contribuyen a la mejora de los indicadores de los procesos, reflejados en los costos de operación y el servicio al cliente.

  2. Pick-up and impact of flexible bodies

    CERN Document Server

    Singh, H

    2016-01-01

    Picking up, laying down, colliding, rolling, and peeling are partial-contact interactions involving moving discontinuities. We examine the balances of momentum and energy across a moving discontinuity in a string, with allowance for injection or dissipation by singular supplies. We split the energy dissipation according to its invariance properties, discuss analogies with systems of particles and connections with the literature on shocks and phase transition fronts in various bodies, and derive a compatibility relation between supplies of momentum and translation-invariant energy. For a moving contact discontinuity between a string and a smooth rigid plane in the presence of gravity, we find a surprising asymmetry between the processes of picking up and laying down, such that steady-state kinks in geometry and associated jumps in tension are not admissible during pick-up. This prediction is consistent with experimental observations. We briefly discuss related problems including the falling folded chain, peeli...

  3. Design and Development of an automated Robotic Pick & Stow System for an e-Commerce Warehouse

    OpenAIRE

    Kumar, Swagat; Majumder, Anima; Dutta, Samrat; Raja, Rekha; Jotawar, Sharath; Kumar, Ashish; Soni, Manish; Raju, Venkat; Kundu, Olyvia; Behera, Ehtesham Hassan Laxmidhar; K. S. Venkatesh; Sinha, Rajesh

    2017-01-01

    In this paper, we provide details of a robotic system that can automate the task of picking and stowing objects from and to a rack in an e-commerce fulfillment warehouse. The system primarily comprises of four main modules: (1) Perception module responsible for recognizing query objects and localizing them in the 3-dimensional robot workspace; (2) Planning module generates necessary paths that the robot end- effector has to take for reaching the objects in the rack or in the tote; (3) Calibra...

  4. SAFER - Company Snapshot - SAFER - Company Snapshot

    Data.gov (United States)

    Department of Transportation — The Company Snapshot is a concise electronic record of company identification, size, commodity information, and safety record, including the safety rating (if any),...

  5. 26 CFR 1.501(c)(12)-1 - Local benevolent life insurance associations, mutual irrigation and telephone companies, and like...

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Local benevolent life insurance associations...) INCOME TAXES (CONTINUED) Exempt Organizations § 1.501(c)(12)-1 Local benevolent life insurance.... (b) The phrase of a purely local character applies to benevolent life insurance associations, and...

  6. 关于pick-up的常见问题

    Institute of Scientific and Technical Information of China (English)

    魏国

    2003-01-01

    @@ 电吉他pick-up的发明是为了使吉他发出更大的声音,也因此有了所谓"电"吉他.我们可以视之为一种能量的转换装置,对音色有很大影响.早期研究发展pick-up多在Fender、Gibson为主的大公司内进行,不同于今日百家争鸣的局面.

  7. Grasp Densities for Grasp Refinement in Industrial Bin Picking

    DEFF Research Database (Denmark)

    Hupfauf, Benedikt; Hahn, Heiko; Bodenhagen, Leon

    in terms of object-relative gripper pose, can be learned from empirical experience, and allow the automatic choice of optimal grasps in a given scene context (object pose, workspace constraints, etc.). We will show grasp densities extracted from empirical data in a real industrial bin picking context...... generated in industrial bin-picking for grasp learning. This aim is achieved by using the novel concept of grasp densities (Detry et al., 2010). Grasp densities can describe the full variety of grasps that apply to specific objects using specific grippers. They represent the likelihood of grasp success...

  8. Robust control, multidimensional systems and multivariable Nevanlinna-Pick interpolation

    CERN Document Server

    Ball, J A

    2009-01-01

    The connection between the standard $H^\\infty$-problem in control theory and Nevanlinna-Pick interpolation in operator theory was established in the 1980s, and has led to a fruitful cross-pollination between the two fields since. In the meantime, research in $H^\\infty$-control theory has moved on to the study of robust control for systems with structured uncertainties and to various types of multidimensional systems, while Nevanlinna-Pick interpolation theory has moved on independently to a variety of multivariable settings. Here we review these developments and indicate the precise connections which survive in the more general multidimensional/multivariable incarnations of the two theories.

  9. Conceptual Design of a Microwave Confocal Resonator Pick-up

    CERN Document Server

    Caspers, Friedhelm; Lofnes, T; Syratchev, I V; Ziemann, Volker

    2004-01-01

    A confocal resonator may be used as a pick-up for frequencies in the multi-GHz region. In this report we present the design, by analytical and numerical methods, of such a device. Furthermore, we discuss engineering issues, such as the damping of unwanted modes, shielding of image fields and manufacturing tolerances. Such a device can be used both as a pick-up and a kicker where the actual structure is several wavelengths away from the beam in the transverse direction. It is intended for highly relativistic beams and does not require changing the particle trajectory, as opposed to a diagnostic wiggler.

  10. Evaluation of peak-picking algorithms for protein mass spectrometry.

    Science.gov (United States)

    Bauer, Chris; Cramer, Rainer; Schuchhardt, Johannes

    2011-01-01

    Peak picking is an early key step in MS data analysis. We compare three commonly used approaches to peak picking and discuss their merits by means of statistical analysis. Methods investigated encompass signal-to-noise ratio, continuous wavelet transform, and a correlation-based approach using a Gaussian template. Functionality of the three methods is illustrated and discussed in a practical context using a mass spectral data set created with MALDI-TOF technology. Sensitivity and specificity are investigated using a manually defined reference set of peaks. As an additional criterion, the robustness of the three methods is assessed by a perturbation analysis and illustrated using ROC curves.

  11. PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system

    DEFF Research Database (Denmark)

    Jansen, Anna M; Nässel, Dick R; Madsen, Kenneth L

    2009-01-01

    in the adult and larval Drosophila central nervous system. PICK1 was found in cell bodies in the subesophageal ganglion, the antennal lobe, the protocerebrum, and the neuroendocrine center pars intercerebralis. The cell types that express PICK1 were identified using GAL4 enhancer trap lines. The PICK1...... (AMPA) receptor subunit GluR2 and the dopamine transporter. PICK1 is strongly implicated in GluR2 trafficking and synaptic plasticity. In mammals, PICK1 has been characterized extensively in cell culture studies. To study PICK1 in an intact system, we characterized PICK1 expression immunohistochemically...... neurons in the neuroendocrine system, which express the transcription factor DIMM and the amidating enzyme peptidylglycine-alpha-hydroxylating monooxygenase (PHM). The PICK1-positive cells include neurosecretory cells that produce the insulin-like peptide dILP2. PICK1 expression in insulin-producing cells...

  12. Fast exchanging mould system for warm extrusion precision forming of pick%截齿温挤压精密成形快换模具系统

    Institute of Scientific and Technical Information of China (English)

    马世博; 孙红磊; 赵军; 邵明杰; 王东风; 马进

    2016-01-01

    针对截齿齿体的结构特点,提出了采用3种温挤压精密成形工艺成形截齿齿体.分别为镦挤工艺成形普通轴对称类截齿、浮动组合模具镦挤工艺成形局部大尺寸类截齿和镦挤联合采用径向挤压工艺成形旋翼类截齿.根据不同工艺和模具特点,设计了截齿齿体温挤压精密成形快换模具系统总体结构,实现了不同上、下凹模成形不同截齿,并且上、下凹模可以根据截齿的具体型号和尺寸进行更换,无需其他模具零件.并进行了温挤压精密成形实验研究,分析了成形后截齿的微观组织.结果表明:温挤压精密成形快换模具系统适合于成形各类截齿,且成形齿体表面质量高、模具成本低、模具更换时间短,显著提高了生产效率.%Considering structural characteristics of the pick body,three kinds of warm extrusion precision forming technologies were proposed to form the pick body,namely,the upset-extrusion technology for common axisymmetric pick,the floating assembling die upset-extrusion technology for local large size pick,and the upset-extrusion with radial-extrusion technology for the rotary wing pick.The quick change mould system of warm extrusion precision forming of pick body was designed according to various technologies and mould requirements to realize the corresponding various picks by different top and bottom dies.The dies could be replaced according to the specific type and the size of pick without replacing the other parts of the mould.The warm extrusion precision forming experiment was carried out,and the microstructure of pick formed was analyzed.The results show that the forming pick by warm extrusion quick change type mould system is suitable for forming different kinds of picks,which are of fine surface quality,low cost,less time for changing mould,and high productivity.

  13. 论晚清政府的保护与萍乡煤矿的开发%On the Protection to Pingxiang Coal Mine of Hanyeping Company From Jiangxi Local Authorities in Late Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    左世元; 刘小畅

    2015-01-01

    Pingxiang Coal Mine has the features such as rich reserves, high grade and long history of mining. After Sheng Xuanhuai (1844—1916), official merchant and entrepreneur in late Qing Dynasty , took over Hanyeping Iron Company, he decided to exploit Pingxiang Coal Mine on large scale by machine to solve the problem of fuel shortage.As an official merchant, Sheng Xuanhuai and Hanyeping Iron Company obtained the support of local authorities in Jiangxi Province and late Qing Government in terms of mining right and ex-pansion of Pingxiang Coal Mine , tax waiving and military protection , which promoted the development of Pingxiang Coal Mine and Hanyeping Company .%萍乡煤炭储量丰富、品位高,开采历史悠久. 盛宣怀接手汉阳铁厂后,为解决燃料匮乏的问题,决定使用机器大规模开采萍乡煤矿. 由于有官办的背景,盛宣怀及汉阳铁厂在进驻萍矿、扩张矿权、减免税厘、军事保护方面均获得了江西地方政府和晚清政府一定的支持,推动了萍矿的开发,促进了汉冶萍公司的发展.

  14. Strategy of adaptation to competition of a local public utility company in a situation of monopoly: the case of Gaz de Strasbourg SA; Strategie d'adaptation a la concurrence d'une societe locale de service public en monopole: le cas de Gaz de Strasbourg SA

    Energy Technology Data Exchange (ETDEWEB)

    Carbonnier, R.

    2001-07-01

    This work deals with the creation process and the definition of the strategy content of Gaz de Strasbourg company at a time when this local monopoly company has to face the deregulation of the gas market and the competition. Its aim is to give help to the company in the identification of the stakes and to adopt and implement the proper strategies in a context dominated by the 'essential facility doctrine' which makes a distinction between the activities linked with the physical network infrastructures, considered as 'natural monopoly', and the commercialization activities of the natural gas product. The strategy proposals are built with the prospect of splitting of the company into two or three different layers of activities and using the concepts and tools of structural analysis, inspired from Michael Porter, and the resources and competences model. It includes an analysis of the activities of a natural gas network company, like Gaz de Strasbourg, and of their evolution in an integrated or in a disintegrated structure. (J.S.)

  15. Multiple People Picking Assignment and Routing Optimization Based on Genetic Algorithm

    Institute of Scientific and Technical Information of China (English)

    孙慧

    2014-01-01

    In order to improve the picking efficiency, reduce the picking time, this paper take artificial picking operation of a certain distribution center which has double-area warehouse as the studying object. Discuss the picking task allocation and routing problems. Establish the TSP model of order-picking system. Create a heuristic algorithm bases on the Genetic Algorithm (GA) which help to solve the task allocating problem and to get the associated order-picking routes. And achieve the simulation experiment with the Visual 6.0C++platform to prove the rationality of the model and the effectiveness of the arithmetic.

  16. Flooded County Picks Up the Pieces

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Local residents in Xiahe County, Gansu Province, clear up debris left by floodwaters on August 20. People’s Daily Online reported that rains triggered mudrock flows that hit seven villages in three towns on August 19. About 3,000 rooms in the county’s houses are reported to have collapsed and more than 11,400 were flooded. Three people were killed and one was missing. A 30-meter section of highway linking Xiahe and other regions was blocked by falling rocks and mud. The report said the county government had mobilized staff for disaster-relief work.

  17. Multivariable operator-valued Nevanlinna-Pick interpolation: a survey

    NARCIS (Netherlands)

    Ball, J.A.; ter Horst, S.

    2010-01-01

    The theory of Nevanlinna-Pick and Carathéodory-Fejér interpolation for matrix- and operator-valued Schur class functions on the unit disk is now well established. Recent work has produced extensions of the theory to a variety of multivariable settings, including the ball and the polydisk (both commu

  18. Effect of horizontal pick and place locations on shoulder kinematics

    NARCIS (Netherlands)

    Könemann, R.; Bosch, T.; Kingma, I.; Dieën, J.H. van; Looze, M.P. de

    2015-01-01

    In this study the effects of horizontal bin locations in an order picking workstation on upper arm elevation, trunk inclination and hand use were investigated. Eight subjects moved (self-paced) light or heavy products (0.2 and 3.0 kg) from a central product bin to an inner or outer order bin (at 60

  19. A case of progressive aphasia without dementia: "temporal" Pick's disease?

    Science.gov (United States)

    Scheltens, P; Hazenberg, G J; Lindeboom, J; Valk, J; Wolters, E C

    1990-01-01

    We report a patient who suffered from progressive aphasia for nine years, before developing mild behavioural disturbances. Sequential computed tomography (CT) scanning and magnetic resonance (MRI) imaging showed progressive bilateral temporal atrophy. The case is thought to be a temporal form of Pick's disease, in which isolated progressive aphasia was the only symptom over many years. Images PMID:2303835

  20. Systematic Approaches to Experimentation: The Case of Pick's Theorem

    Science.gov (United States)

    Papadopoulos, Ioannis; Iatridou, Maria

    2010-01-01

    In this paper two 10th graders having an accumulated experience on problem-solving ancillary to the concept of area confronted the task to find Pick's formula for a lattice polygon's area. The formula was omitted from the theorem in order for the students to read the theorem as a problem to be solved. Their working is examined and emphasis is…

  1. Expanding the Black Woman's Horizon: Picking From a Higher Bush ...

    African Journals Online (AJOL)

    Expanding the Black Woman's Horizon: Picking From a Higher Bush Motif in Zora ... While bringing up Janie, Nanny overprotects her and shields her from the ... In her quest, Janie discovers that it is not comfort or money that brings about love ...

  2. Benchmarking motion planning algorithms for bin-picking applications

    DEFF Research Database (Denmark)

    Iversen, Thomas Fridolin; Ellekilde, Lars-Peter

    2017-01-01

    Purpose For robot motion planning there exists a large number of different algorithms, each appropriate for a certain domain, and the right choice of planner depends on the specific use case. The purpose of this paper is to consider the application of bin picking and benchmark a set of motion...

  3. Vision guided robot bin picking of cylindrical objects

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg; Dyhr-Nielsen, Carsten

    1997-01-01

    In order to achieve increased flexibility on robotic production lines an investigation of the rovbot bin-picking problem is presented. In the paper, the limitations related to previous attempts to solve the problem are pointed uot and a set of innovative methods are presented. The main elements h...

  4. 75 FR 12329 - Union Pacific Railroad Company-Temporary Trackage Rights Exemption-BNSF Railway Company

    Science.gov (United States)

    2010-03-15

    ... Surface Transportation Board Union Pacific Railroad Company--Temporary Trackage Rights Exemption--BNSF Railway Company AGENCY: Surface Transportation Board, DOT. ACTION: Partial revocation of exemption... Railway Company (BNSF) to extend to December 18, 2010, the expiration date of the local trackage rights...

  5. Pick sequencing optimization problem in the rotary rack S/R system

    Institute of Scientific and Technical Information of China (English)

    Pan ZHANG; Lei JIA; Guohui TIAN

    2004-01-01

    The problem of pick sequencing in the rotary rack S/R system (PPS-RRS) is investigated with the objective of minimizing the execution time.The rotary rack S/R system consists of one S/R machine and multiple levels of carousels that can rotate independently in bi-directions.The routing policy,namely the decision on the storage or retrieval sequence,dominates the efficiency and the throughput for such S/R systems,due to the complicated relationship between all levels of carousels and the S/R machine.For the purpose of optimizing the PPS-RRS,a computational model is developed in terms of execution time for picking multiple items in one trip.Characteristics of the PPS-RRS are analyzed and a local search heuristic based on a newly proposed neighborhood is presented.Integrated with the proposed local search procedure a new hybrid genetic algorithm is developed.Experimental results demonstrate the structure characteristics of good sequence and the efficiency and effectiveness of the proposed sequencing algorithms.

  6. Close up of the pick and place tool carrying a dummy silicon sensor.

    CERN Multimedia

    Bernd Surrow

    1999-01-01

    The gantry positioning head contains a vacuum pick-up system thatallows several different pick-up tools to be used. This one isdesigned to pick up the silicon sensors. The pick-up tool containsa pressure sensitive contact which can stop the motion of the machine when the tool touches a fixed object. The shiny cylinderis the end of the microscope optics of the CCD camera.

  7. Metaheuristics for Order Batching and Sequencing in Manual Order Picking Systems

    OpenAIRE

    Sebastian Henn; Verena Schmid

    2011-01-01

    Order picking deals with the retrieval of articles from their storage locations in order to satisfy customer requests. A major issue in manual order picking systems concerns of the transformation and consolidation of customer orders into picking orders (order batching). In practice, customer orders have to be completed by certain due dates in order to avoid delay in the shipment to customers or in production. The composition of the picking orders, their processing times and the sequence accor...

  8. Automatic picking and earthquake relocation for the Antilles subduction zone (1972-2013)

    Science.gov (United States)

    Massin, F.; Amorèse, D.; Bengoubou-Valerius, M.; Bernard, M.

    2013-12-01

    Locations for earthquake recorded in the Antilles subduction zone are processed separately by regional observatories and ISC. There is no earthquake location catalog available compiling all available first arrival data. We aim to produce a best complete earthquake catalog by merging all available first arrival data for better constrains on earthquake locations. ISC provides the first arrival data of 29243 earthquakes (magnitude range from 1.4 to 6.4) recorded by PRSN (Porto Rico), SRC (British West Indies), and form FUNVISIS (Venezuela). IPGP provided the first arrival data of 68718 earthquakes (magnitude from 0.1 to 7.5) recorded by OVSG (Guadeloupe, 53226 earthquakes since 1981) and by OVSM (Martinique, 29931 earthquakes since 1972). IPGP also provides the accelerometer waveform data of the GIS-RAP network in the Antilles. The final catalog contains 84979 earthquakes between 1972 and 2013, 24528 of which we compiled additional data. We achieved automatic picking using the Component Energy Correlation Method. The CECM provide high precision phase detection, a realistic estimation of picking error and realistic weights that can be used with manual pick weights. The CECM add an average of 3 P-waves and 2 S-waves arrivals to 3846 earthquakes recoded by the GIS-RAP network since 2002. Cluster analysis, earthquake local tomography and relative locations are to be applied in order to image active faulting and migration of seismicity. This will help to understand seismic coupling in the seismogenic zone as well as triggering mechanisms of intermediate depth seismicity like fluid migration beneath the volcanic arc.

  9. 7 CFR 51.1236 - U.S. Fancy Hand Picked.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false U.S. Fancy Hand Picked. 51.1236 Section 51.1236 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards.... Fancy Hand Picked. U.S. Fancy Hand Picked shall consist of cleaned Virginia type peanuts in the...

  10. A Preliminary Analysis of the Phenomenology of Skin-Picking in Prader-Willi Syndrome

    Science.gov (United States)

    Morgan, Jessica R.; Storch, Eric A.; Woods, Douglas W.; Bodzin, Danielle; Lewin, Adam B.; Murphy, Tanya K.

    2010-01-01

    To examine the nature and psychosocial correlates of skin-picking behavior in youth with Prader-Willi Syndrome (PWS). Parents of 67 youth (aged 5-19 years) with PWS were recruited to complete an internet-based survey that included measures of: skin-picking behaviors, the automatic and/or focused nature of skin-picking, severity of skin-picking…

  11. 7 CFR 51.1235 - U.S. Jumbo Hand Picked.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false U.S. Jumbo Hand Picked. 51.1235 Section 51.1235 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards.... Jumbo Hand Picked. U.S. Jumbo Hand Picked shall consist of cleaned Virginia type peanuts in the...

  12. Determining Number of Zones in a Pick-and-pack Orderpicking System

    NARCIS (Netherlands)

    T. Le-Duc (Tho); M.B.M. de Koster (René)

    2005-01-01

    textabstractIn this study we consider a pick-to-pack orderpicking system, in which batches of orders are picked simultaneously from different(work) zones by a group of order pickers. After picking, the orders are transported by a conveyor to the next station for packing. Our aim is to determine the

  13. Aligning order picking methods, incentive systems, and regulatory focus to increase performance

    NARCIS (Netherlands)

    J. de Vries (Jelle); M.B.M. de Koster (René); D.A. Stam (Daan)

    2015-01-01

    textabstractA unique controlled field experiment investigates order picking performance (in terms of productivity and quality). We examined three manual picker-to-parts order picking methods (parallel, zone, and dynamic zone picking) under two different incentive systems (competition- based versus c

  14. Aligning order picking methods, incentive systems, and regulatory focus to increase performance

    NARCIS (Netherlands)

    J. de Vries (Jelle); M.B.M. de Koster (René); D.A. Stam (Daan)

    2015-01-01

    textabstractA unique controlled field experiment investigates order picking performance (in terms of productivity and quality). We examined three manual picker-to-parts order picking methods (parallel, zone, and dynamic zone picking) under two different incentive systems (competition- based versus

  15. 21 CFR 872.6650 - Massaging pick or tip for oral hygiene.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Massaging pick or tip for oral hygiene. 872.6650... (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6650 Massaging pick or tip for oral hygiene. (a) Identification. A massaging pick or tip for oral hygiene is a rigid, pointed device...

  16. Skin picking disorder with co-occurring body dysmorphic disorder.

    Science.gov (United States)

    Grant, Jon E; Redden, Sarah A; Leppink, Eric W; Odlaug, Brian L

    2015-09-01

    There is clinical overlap between skin picking disorder (SPD) and body dysmorphic disorder (BDD), but little research has examined clinical and cognitive correlates of the two disorders when they co-occur. Of 55 participants with SPD recruited for a neurocognitive study and two pharmacological studies, 16 (29.1%) had co-occurring BDD. SPD participants with and without BDD were compared to each other and to 40 healthy volunteers on measures of symptom severity, social functioning, and cognitive assessments using the Stop-signal task (assessing response impulsivity) and the Intra-dimensional/Extra-dimensional Set Shift task (assessing cognitive flexibility). Individuals with SPD and BDD exhibited significantly worse picking, significantly worse overall psychosocial functioning, and significantly greater dysfunction on aspects of cognitive flexibility. These results indicate that when SPD co-occurs with BDD unique clinical and cognitive aspects of SPD may be more pronounced. Future work should explore possible subgroups in SPD and whether these predict different treatment outcomes.

  17. Picking and Choosing the ‘Sovereign’Border

    DEFF Research Database (Denmark)

    Parker, Noel; Adler-Nissen, Rebecca

    2012-01-01

    We argue that the continued persistence of borders is an effect of their constitutive role for the many dimensions of a social particular. States cannot choose to have a border; but they can and do make choices amongst the materials available on the various planes of inscription for bordering....... For contemporary states the planes have become increasingly disaggregated, in the sense that they do not fall into place at one and the same border. Thus, states have to pick and choose different articulations (often inconsistently) on different planes. We illustrate these ideas with instances, present......-day and historical, of bordering. A corollary of there being more need to pick and choose is that articulations of sovereignty change. So, sovereignty is increasingly the material of ‘sovereignty games’, where sovereignty is used as a political instrument. In sum, our theory directs attention to state bordering...

  18. Impact Factors of Choosing Willingness for Picking up Service

    Directory of Open Access Journals (Sweden)

    Jun-Jie Xu

    2013-08-01

    Full Text Available To obtain promotion schemes for picking up service in e-commerce logistics system, a regression analysis model of customer willingness was established with four types of independent variables including personal characteristics, parcel characteristics, environment characteristics and service evaluation on traditional home delivery. An empirical study with 479 samples collected from Taobao networks was conducted, if controlling gender and age, significant effects were confirmed such as perceived convenience on home delivery, age of online shopping, frequency of online shopping and parcel’s value. However the anticipated effects of traffic congestion, parcel dimensions, service evaluation on home delivery and other factors were not proved. The results investigated that attraction of picking up service was limited, related firms should propose a targeted marketing plan focusing on customer characteristics and parcel properties

  19. Abnormal brain activation in excoriation (skin-picking) disorder

    DEFF Research Database (Denmark)

    Odlaug, Brian L.; Hampshire, Adam; Chamberlain, Samuel R

    2016-01-01

    Background: Excoriation (skin-picking) disorder (SPD) is a relatively common psychiatric condition whose neurobiological basis is unknown. Aims: To probe the function of fronto-striatal circuitry in SPD. Method: Eighteen participants with SPD and 15 matched healthy controls undertook an executive...... involved in habit formation, action monitoring and inhibition appear involved in the pathophysiology of SPD. Implications exist for understanding the basis of excessive grooming and the relationship of SPD with putative obsessive-compulsive spectrum disorders.......Background: Excoriation (skin-picking) disorder (SPD) is a relatively common psychiatric condition whose neurobiological basis is unknown. Aims: To probe the function of fronto-striatal circuitry in SPD. Method: Eighteen participants with SPD and 15 matched healthy controls undertook an executive...

  20. The storage location assignment problem: application in an agribusiness company

    Directory of Open Access Journals (Sweden)

    Helton C. Gomes

    2015-09-01

    Full Text Available The goal of this work is propose an efficient storage scheme for a company in the agribusiness sector. The company studied herein is located in the Alto Paranaíba region of Minas Gerais, and exports coffee beans. Efficient storage can provide improvements in the use of space, operational resources, and staff time, as well as facilitating the order picking process. To accomplish this, the problem was mathematically modeled as a Storage Location Assignment Problem (SLAP, aimed at minimizing handling costs and maximizing space utilization and storage efficiency. The mathematical model using the company data was solved using the CPLEX solver, version 12.1. The results obtained were compared with the actual company scenario, and several advantages were observed.

  1. 本土服装上市公司的多元化发展困境与解决思路%Research on the Diversiifed Development of Locally Listed Apparel Companies:Dilemma and Solutions

    Institute of Scientific and Technical Information of China (English)

    王革非

    2014-01-01

    Along with the step-by-step withdrawal of U.S. QE, the contraction of China’s banking credit scale and also the weakening financing function of the real estate market and capital market, locally listed apparel companies are facing increasing constraints when extending their business to the high-profit fields such as the real estate industry. However, under the background that the apparel industry is losing competitive advantages and the difficult situation of the apparel industry is hardly improved, the diversified development model adopted by clothing listed companies will exist in a very long period of time, and comparatively speaking, the incremental related diversification strategy could be used as the preferred strategic choice for listed apparel companies.%随着美国QE逐步退出、我国银行信贷规模收紧、房地产及资本市场融资功能转弱,本土服装上市公司向地产等高收益领域的多元化发展受到制约。然而在服装业比较优势走弱不可逆转、行业大环境难以改善的背景下,服装上市公司的多元化发展模式依然会长期存在,但相较而言,增量式同界异业相关多元化发展模式或可作为服装上市公司的战略首选。

  2. SIMILARITIES AND DIFFERENCES BETWEEN COMPANIES

    Directory of Open Access Journals (Sweden)

    NAGY CRISTINA MIHAELA

    2015-05-01

    Full Text Available act: Similarities between the accounting of companies and territorial administrative units accounting are the following: organizing double entry accounting; accounting method both in terms of fundamental theoretical principles and specific practical tools. The differences between the accounting of companies and of territorial administrative units refer to: the accounting of territorial administrative units includes besides general accounting (financial also budgetary accounting, and the accounts system of the budgetary accounting is completely different from that of companies; financial statements of territorial administrative units to which leaders are not main authorizing officers are submitted to the hierarchically superior body (not at MPF; the accounts of territorial administrative units are opened at treasury and financial institutions, accounts at commercial banks being prohibited; equity accounts in territorial administrative units are structured into groups of funds; long term debts have a specific structure in territorial administrative units (internal local public debt and external local public debt.

  3. Climate Change and Fruit-Picking Tourism: Impact and Adaptation

    Directory of Open Access Journals (Sweden)

    Jun Liu

    2016-01-01

    Full Text Available The purpose of this work is to present phenology as a valid indicator and methodology for monitoring and assessing the impact of climate change on plant-based tourist activities. Fruit-picking has become a popular rural tourism activity worldwide. However, fruit maturity dates (FMD have been affected by climate change (CC, which has in turn profoundly affected fruit-picking tourism activities (FPTA. In this paper, phenological data on the FMD for 45 types of plants in 1980–2012, dates for more than 200 fruit-picking festivals, and data on monthly average air temperature in 1980–2013 were used to assess the impact of CC on FPTA by wavelet and correlation analyses. The findings indicated that the study area had been significantly affected by CC. Prevailing temperatures at one or three months prior have a decisive influence on FMD. Among the 11 plants directly related to FPTA, the FMD of four were significantly advanced, while 6-7 were significantly delayed owning to increased temperature. Of the 11 FPTA, only two had realized the impact of CC and had adjusted festival opening dates based on dynamic changes. However, a considerable number of festival activities remained fixed or scheduled on the weekends.

  4. Pick-up and impact of flexible bodies

    Science.gov (United States)

    Singh, H.; Hanna, J. A.

    2017-09-01

    Picking up, laying down, colliding, rolling, and peeling are partial-contact interactions involving moving discontinuities. We examine the balances of momentum and energy across a moving discontinuity in a string, with allowance for injection or dissipation by singular supplies. We split the energy dissipation according to its invariance properties, discuss analogies with systems of particles and connections with the literature on shocks and phase transition fronts in various bodies, and derive a compatibility relation between supplies of momentum and translation-invariant energy. For a moving contact discontinuity between a string and a smooth rigid plane in the presence of gravity, we find a surprising asymmetry between the processes of picking up and laying down, such that steady-state kinks in geometry and associated jumps in tension are not admissible during pick-up. This prediction is consistent with experimental observations. We briefly discuss related problems including the falling folded chain, peeling of an adhesive tape, and the ;chain fountain;. Our approach is applicable to the study of impact and locomotion, and to systems such as moored floating structures and some musical instruments that feature vibrating string and cable elements interacting with a surface.

  5. Peak picking multidimensional NMR spectra with the contour geometry based algorithm CYPICK.

    Science.gov (United States)

    Würz, Julia M; Güntert, Peter

    2017-01-01

    The automated identification of signals in multidimensional NMR spectra is a challenging task, complicated by signal overlap, noise, and spectral artifacts, for which no universally accepted method is available. Here, we present a new peak picking algorithm, CYPICK, that follows, as far as possible, the manual approach taken by a spectroscopist who analyzes peak patterns in contour plots of the spectrum, but is fully automated. Human visual inspection is replaced by the evaluation of geometric criteria applied to contour lines, such as local extremality, approximate circularity (after appropriate scaling of the spectrum axes), and convexity. The performance of CYPICK was evaluated for a variety of spectra from different proteins by systematic comparison with peak lists obtained by other, manual or automated, peak picking methods, as well as by analyzing the results of automated chemical shift assignment and structure calculation based on input peak lists from CYPICK. The results show that CYPICK yielded peak lists that compare in most cases favorably to those obtained by other automated peak pickers with respect to the criteria of finding a maximal number of real signals, a minimal number of artifact peaks, and maximal correctness of the chemical shift assignments and the three-dimensional structure obtained by fully automated assignment and structure calculation.

  6. Particle quality assessment and sorting for automatic and semiautomatic particle-picking techniques.

    Science.gov (United States)

    Vargas, J; Abrishami, V; Marabini, R; de la Rosa-Trevín, J M; Zaldivar, A; Carazo, J M; Sorzano, C O S

    2013-09-01

    Three-dimensional reconstruction of biological specimens using electron microscopy by single particle methodologies requires the identification and extraction of the imaged particles from the acquired micrographs. Automatic and semiautomatic particle selection approaches can localize these particles, minimizing the user interaction, but at the cost of selecting a non-negligible number of incorrect particles, which can corrupt the final three-dimensional reconstruction. In this work, we present a novel particle quality assessment and sorting method that can separate most erroneously picked particles from correct ones. The proposed method is based on multivariate statistical analysis of a particle set that has been picked previously using any automatic or manual approach. The new method uses different sets of particle descriptors, which are morphology-based, histogram-based and signal to noise analysis based. We have tested our proposed algorithm with experimental data obtaining very satisfactory results. The algorithm is freely available as a part of the Xmipp 3.0 package [http://xmipp.cnb.csic.es].

  7. Metaheuristics for the Order Batching Problem in Manual Order Picking Systems

    Directory of Open Access Journals (Sweden)

    Sebastian Henn

    2010-05-01

    Full Text Available In manual order picking systems, order pickers walk or drive through a distribution warehouse in order to collect items which are requested by (internal or external customers. In order to perform these operations efficiently, it is usually required that customer orders are combined into (more substantial picking orders of limited size. The Order Batching Problem considered in this paper deals with the question of how a given set of customer orders should be combined such that the total length of all tours is minimized which are necessary to collect all items. The authors introduce two metaheuristic approaches for the solution of this problem: the first one is based on Iterated Local Search; the second on Ant Colony Optimization. In a series of extensive numerical experiments, the newly developed approaches are benchmarked against classic solution methods. It is demonstrated that the proposed methods are not only superior to existing methods but provide solutions which may allow distribution warehouses to be operated significantly more efficiently.

  8. The Milwaukee Inventory for the Dimensions of Adult Skin Picking (MIDAS): initial development and psychometric properties.

    Science.gov (United States)

    Walther, Michael R; Flessner, Christopher A; Conelea, Christine A; Woods, Douglas W

    2009-03-01

    This article describes the development and initial psychometric properties of the Milwaukee Inventory for the Dimensions of Adult Skin picking (MIDAS), a measure designed to assess "automatic" and "focused" skin picking. Data were collected from 92 participants who completed an anonymous internet-based survey. Results of an exploratory factor analysis revealed a two-factor solution. Factors 1 ("focused" picking scale) and 2 ("automatic" picking scale) each consisted of 6 items, and preliminary data demonstrated adequate internal consistency, good construct validity, and good discriminant validity. The MIDAS provides researchers with a reliable and valid assessment of "automatic" and "focused" skin picking.

  9. Study of Air Pollution Due to Plasma Cutting Process and Designing Local Ventilation System with Collector in Central Workshop of Mobarakeh Steel Company

    Directory of Open Access Journals (Sweden)

    Farideh Atabi

    2014-06-01

    Full Text Available Background & Objectives : Cutting leads to production of different hazardous agents such as fumes, particles, gases and vapors. In various studies, the effects of fumes, gases, and vapors on workers and environment have been proved. Meanwhile, cutting alloying plates with plasma cutting machine due to containing various alloy materials produces a lot of air pollution. Therefore, using the ventilation system to remove the mentioned pollution has always been noteworthy. Method: This study was performed on plasma cutting machine at Mobarakeh Steel Company. At first, according to ASTM the elements from alloy plates with optical emission spectrometry crm-35000-quantometery were detected, the air pollution from cutting the mentioned plates was sampled and measured using NIOSH 7300 method and according to the ACGIH:VS-72-20, VS-70-12, VS-70-11 VS-916 push-pull ventilation with bag filter collector was designed. Results: Results of sampling from pollution of cutting the alloy material, concentration of iron, lead and cadmium fumes were more than the standard limits. After calculation for push system, air flow volume of 195.163 cfm, outgoing air velocity of 5937.4 fpm and for pull system air flow volume of 12498 cfm, minimum duct velocity of 3000 fpm and velocity pressure of duct of 0.717 inwg, for fan, total pressure of 6.301 inwg, static pressure of 0.587 inwg and power of 20.65 Bhp and for collector with pulse jet cleaning system air to cloth ratio of 7 and dimensions of 6.88ft × 6.56ft × 9.84ft were obtained. Conclusion: The result of study indicated that push pull ventilation compared to other ventilation system s for plasma cutting has more efficiency and makes suitable control for pollution.

  10. Ultimate control, corporate governance, and overinvestment by local state- owned companies%终极控制、公司治理与地方国有公司过度投资

    Institute of Scientific and Technical Information of China (English)

    刘星; 连军

    2011-01-01

    By choosing Chinese local state - owned listed companies during the period of 2005 - 2008 as samples, from the perspective of free - cash - flow agency problems,the corporate governance effects of cash - flow rights and control rights are studied when local government is uhimate controller. The empirical re.suits indicate that ( 1 ) only when cash - flow rights held by local government is at a higher level, the cash - flow rights have the incentive effect, which can bind the behavior of abusing five cash flow for over investment; However, when cash -flow rights is at a lower level, the incentive effect is not found. (2) the divergence between control rights and cash - flow rights has the entrenchment effect. However, when cash - flow rights held by local government is at a higher level, the cost of overinvastment for private benefits is increasing, therefore, the entrenchment effect becomes moderate accordingly. The study provides enlightenment for understanding the proxy conflict between the ultimate shareholder and external minority shareholders in local state - owned listed companies during the period of transition economies, and enriches empirical literatures involving the study on corporate governance under the control of government.%以2005—2008年中国地方国有上市公司为样本,从公司滥用自由现金流进行过度投资视角出发。研究地方政府作为上市公司终极控制人时,其持有的现金流权以及“控制权与现金流权分离”所内涵的公司治理效应。实证结果表明:(1)只有当地方政府持有的现金流权较大时,现金流权的“激励效应”才会显现,能够抑制公司滥用自由现金流进行过度投资的行为;当持有的现金流权较小时,不足以发挥激励作用。(2)控制权与现金流权分离表现出“堑壕效应”。但是当地方政府持有的现金流权较大时,以过度投资攫取控制权私利的成本加大,这种“堑壕效应”会

  11. AN ANALYSIS OF TEAMWORK IN THE INSURANCE COMPANIES

    National Research Council Canada - National Science Library

    Luka Stanić; Ivana Miklošević; Jerko Glavaš

    2017-01-01

    ...: a combination of science, the real sector and local government. The basis of this research is teamwork in insurance companies operating in eastern Croatia whose indicators reflect on other insurance companies in Croatia and beyond...

  12. Skin picking behaviors: An examination of the prevalence and severity in a community sample.

    Science.gov (United States)

    Hayes, Stephania L; Storch, Eric A; Berlanga, Lissette

    2009-04-01

    Body-focused repetitive behaviors such as skin picking have gained recent attention in the psychiatric literature. Prevalence of skin picking has not been well researched and is difficult to estimate; however, consequences of such behaviors can include severe medical complications and impaired social and occupational functioning. Given this, this study examined: (1) the prevalence and severity of skin picking in a nonclinical community sample, and (2) associations between skin picking and other measures of psychological functioning. Three hundred and fifty-four participants completed measures of psychological functioning and skin picking frequency and severity. A total of 62.7% endorsed some form of skin picking and 5.4% reported clinical levels of skin picking and associated distress/impact. Direct associations were found between skin picking and depressive, anxiety, and obsessive-compulsive symptoms, which may support the emotional regulation model of pathological skin picking. To establish proper diagnostic classification of pathological skin picking and optimize treatment planning and outcome, further investigation of functional relationships between skin picking and affective distress is needed.

  13. Sistema de apoio à decisão para a otimização da roteirização da separação manual de peças em armazém utilizando planilhas eletrônicas The order-picking routing problem for low-level order picker in a warehouse

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Bonassa

    2011-01-01

    Full Text Available O presente trabalho trata do problema da determinação de rota de separação manual de peças em armazéns que minimize a distância total percorrida pelo separador. O problema abordado é prático e comum a várias empresas, com impacto nos custos operacionais e relevância para a assertividade em relação aos itens coletados. Ainda assim, o tema é pouco explorado nos estudos de roteirização disponíveis em língua portuguesa e muitas empresas optam por confiar nas rotas criadas empiricamente pelos separadores. O método de roteirização proposto é baseado em programação dinâmica e foi implementado em ambiente de planilha eletrônica. O algoritmo utilizado como método de solução é eficiente, flexível e genérico para ser utilizado em armazéns com dois corredores transversais, independente da política de localização ou separação adotada e, por sua facilidade de implementação e utilização, representa uma alternativa de roteirização eficiente e de baixo custo para pequenas e médias empresas.This work deals with the problem of finding the route that minimizes the total distance traveled by individuals working in the picking process in a warehouse. This problem is practical and common to several companies impacting their operational costs, and it is relevant for reducing miss-picking. Despite its importance, this issue has been little explored in the scientific literature in Portuguese, and thus many companies still rely on their picking personnel to subjectively determine the best routes to be followed. We propose a solution algorithm based on dynamic programming, which was implemented in spreadsheet environment. It is flexible and generic thus allowing its use in any warehouse with two traverse corridors, independent of the localization policy or separation strategy adopted. Furthermore, due to its easy implementation and utilization, this algorithm represents an efficient low cost routing alternative for small and

  14. Diagnosis of Pick Disease%Pick病的诊断

    Institute of Scientific and Technical Information of China (English)

    贾建军; 卢文甫; 王鲁宁; 汤洪川; 尹岭

    2001-01-01

    目的探讨Pick病(Pick disease)诊断的正确性。方法分析2例临床上曾诊断为阿尔茨海默病(Alzheimer disease,AD),经核磁共振成像(MRI)检查证实的Pick病,其中1例经正电子发射型计算机断层扫描(PET)得到进一步证实。结果 Pick病与AD比较有如下特点:①特殊的语言方式及语言改变;②临床上以缓慢进展的性格改变及社会活动能力衰退为主,而记忆力、理解判断力、计算力障碍等出现相对较晚;③病程中有不同程度的Klüver-Bucy综合征表现;④脑MRI检查提示:额和(或)颞叶萎缩,颞极为著;⑤PET检查提示:双侧额、颞叶代谢减低,颞极明显。 结论根据Pick病临床表现及神经影像学特征,在排除AD及其它脑变性病的基础上,生前诊断Pick病是可能的。%Objective To explore the definite diagnosis of pick disease. Methods Two cases of the pick disease diag nosised by clinical and MRI findings,one of them certified by PET. The patients had been diagnosised as Alzheimer dis ease(AD) before. Results There are the following features on pick disease as compared with AD:①The special type of speech and speech disorder;②The slowly progressive change of character and involution of social action emerged earlier in clinical and the disturbance of memory,comprehension and calculation emerged later;③Klüver-Bucy syndrome can be found in the course of the illness;④MRI showed:the atrophy of frontal-temporal lobe is obviously, especially on tempo ral pole;⑤Frontal-temporal lobe deficits on PET,especially on temporal pole. Conclusion The antemortem diagnosis of pick disease might be possible on the detailed basis of clinical manifestations, MRI and PET features, but other neu rodegeneration disorders such as AD should be ruled out.

  15. Respiratory symptoms among waste-picking child laborers: a cross-sectional study.

    Science.gov (United States)

    Hernández Romero, Danilo A; Oudin, Anna; Strömberg, Ulf; Karlsson, Jan-Eric; Welinder, Hans; Sequeira, Gustavo; Blanco, Luís; Jiménez, Mario; Sánchez, Félix; Albin, María

    2010-01-01

    This study evaluates respiratory symptoms, lung function, and exposure to airborne particles among waste-picking children. We enrolled 103 waste-picking children at a dump in Managua, Nicaragua and 103 children who do not pick waste. Exposure to airborne particles was assessed by area sampling. Health data were obtained from a questionnaire, clinical examination, and spirometry. Exposure effects were evaluated with multivariate regression analysis. Exposure to particles exceeded national and international standards. Wheezing among children was related to exposure status, with waste-picking children who are both "never highly exposed" and "ever highly exposed" having greater prevalence of wheezing compared to the children who do not pick waste. FEV1 among "ever highly exposed" waste-picking children with wheeze was 13% lower than non-waste-picking children with wheeze. Exposure to small particles was unacceptably high and associated with wheeze and decreased lung function.

  16. The Skin Picking Impact Project: phenomenology, interference, and treatment utilization of pathological skin picking in a population-based sample.

    Science.gov (United States)

    Tucker, Benjamin T P; Woods, Douglas W; Flessner, Christopher A; Franklin, Shana A; Franklin, Martin E

    2011-01-01

    The current study examined the characteristics of pathological skin picking (PSP) in a population-based sample. Participants were recruited through several online resources for PSP and related conditions to complete a web-based survey assessing the functional and topographical phenomenology, physical and psychosocial impact, treatment utilization, and associated psychopathology of PSP. A total of 1663 participants consented, of whom 760 were over 18 and met study criteria for PSP. Results showed considerable heterogeneity in picking methods, body sites, and function (e.g., regulation of emotional, sensory, and cognitive states). Participants generally reported moderate psychosocial and physical impact from picking and tended to perceive available treatment as poor in quality. Severity of associated symptoms of psychopathology (depression, anxiety, and stress) was comparable to severity levels found in previous samples of persons with trichotillomania and obsessive-compulsive disorder. Severity of PSP was a statistically significant predictor of overall impairment after controlling for depression and anxiety symptoms. Results suggest that PSP is a significant public health concern in need of further rigorous investigation.

  17. Liquidation of the company

    OpenAIRE

    Procházka, Michal

    2011-01-01

    This work deals with the liquidation of the company focusing on commercial companies. It describes whole process of liquidation from decision to liquidate to delete the company from the Commercial Register. The work also focuses on legal, accounting and tax site of liquidation. Accounting practices in the liquidation process are illustrated on the example of a fictive company.

  18. The effects of brief cognitive-behaviour therapy for pathological skin picking: A randomized comparison to wait-list control

    NARCIS (Netherlands)

    Schuck, K.; Keijsers, G.P.J.; Rinck, M.

    2011-01-01

    Thirty-four college students suffering from pathological skin picking were randomly assigned to a four-session cognitive-behavioural treatment (n = 17) or a waiting-list condition (n = 17). Severity of skin picking, psycho-social impact of skin picking, strength of skin-picking-related dysfunctional

  19. Implementation of a new picking procedure in the Antelope software

    Science.gov (United States)

    Tiberi, Lara; Costa, Giovanni; Spallarossa, Daniele

    2014-05-01

    Automatic estimates of earthquake parameters continues to be of considerable interest to the seismological community. In this study we present a new automatic procedure for a quasi real-time location of events. This procedure is a combination of the solid and tested Antelope sotfware with a new picking procedure, the AutoPicker (DipTeRiS, University of Genova). Antelope picking procedure consists on: a) Prefiltering into different frequency pass bands; b) Run STA/LTA detectors in one or more channels of the waveform data; c) Associate event locations by searching over one or more spatial grids for a candidate hypocenter that produces theoretical time moveout (P and S) to each station that most closely matches the observations. The main characteristics of the AutoPicker picking algorithm are: a) Pre-filtering and envelope calculation to prearrange the onset; b) Preliminary detection of P onset using the AIC based picker; c) P validation, Signal Variance/Noise Variance analysis sample by sample; d) Preliminary earthquake location; e) Detection of S onset adopting the AIC based picker; f) S/N analysis, S validation; g) Earthquake location. We have applied these two automatic procedures to the Emilia sequence occurred in May-June 2012. In this comparison the distribution of the differences between the manual and the two automatic P-onset are comparable. The average values of P differences are similar, but we have to point out that the AutoPicker procedure gives a st.deviation value lower than the Antelope ones and most important it picks the 16% of phases more than the other algoritm. For S-phases the AutoPicker algorithm picks 178 phases with a mean value of 0.09 sec, instead of the 16s of Antelope with a mean value of 3.75 sec. For more than 90% events the epicentral differences of AutoPicker is less than 5 kms, instead of the Antelope differences which are less than 10 kms. For the depth differences the mean values and the distributions of the two procedures are

  20. Experimental functional analysis of severe skin-picking behavior in Prader-Willi syndrome.

    Science.gov (United States)

    Hall, Scott S; Hustyi, Kristin M; Chui, Clara; Hammond, Jennifer L

    2014-10-01

    Skin picking is an extremely distressing and treatment resistant behavior commonly shown by individuals with Prader-Willi syndrome (PWS). However, with the exception of a limited number of published single-case and survey studies, little is known about the environmental determinants of skin picking in this population. In this study, functional analyses were conducted with thirteen individuals with PWS, aged 6-23 years, who engaged in severe skin-picking behavior. In addition to the conditions typically employed in a functional analysis (i.e., alone, attention, play, demand), we included an ignore condition to examine potential effects of stimulus control by the presence of an adult. Twelve participants engaged in skin picking during the functional analysis, with the highest levels occurring in the alone and ignore conditions for eight participants, suggesting that skin picking in these participants was maintained by automatic reinforcement. For the remaining four participants, an undifferentiated pattern of low-rate skin picking was observed across conditions. These data confirm previous studies indicating that skin picking in PWS may be maintained most often by automatically produced sensory consequences. There were no associations between demographic characteristics of the participants (e.g., sex, age, IQ or BMI) and levels of skin picking observed in the functional analysis. Additional investigations are needed to identify the nature of the sensory consequences produced during episodes of skin picking in PWS. Behavioral interventions designed to extinguish or compete with the potential sensory consequences arising from skin picking in PWS are also warranted.

  1. Wavefront picking for 3D tomography and full-waveform inversion

    KAUST Repository

    AlTheyab, Abdullah

    2016-09-08

    We have developed an efficient approach for picking firstbreak wavefronts on coarsely sampled time slices of 3D shot gathers. Our objective was to compute a smooth initial velocity model for multiscale full-waveform inversion (FWI). Using interactive software, first-break wavefronts were geometrically modeled on time slices with a minimal number of picks. We picked sparse time slices, performed traveltime tomography, and then compared the predicted traveltimes with the data in-between the picked slices. The picking interval was refined with iterations until the errors in traveltime predictions fell within the limits necessary to avoid cycle skipping in early arrivals FWI. This approach was applied to a 3D ocean-bottom-station data set. Our results indicate that wavefront picking has 28% fewer data slices to pick compared with picking traveltimes in shot gathers. In addition, by using sparse time samples for picking, data storage is reduced by 88%, and therefore allows for a faster visualization and quality control of the picks. Our final traveltime tomogram is sufficient as a starting model for early arrival FWI. © 2016 Society of Exploration Geophysicists.

  2. Wear Assessment of Conical Pick used in Coal Cutting Operation

    Science.gov (United States)

    Dewangan, Saurabh; Chattopadhyaya, Somnath; Hloch, Sergej

    2015-09-01

    Conical pick is a widely used tool for cutting coal in mines. It has a cemented carbide tip inserted in a steel body. Cemented carbide has been in use for many years for coal/rock cutting because it has the optimum combination of hardness, toughness and resistance against abrasive wear. As coal/rock is a heterogeneous substance, the cutting tool has to undergo various obstructions at the time of excavation that cause the tool to wear out. The cracks and fractures developing in the cemented carbide limit the life of the tool. For a long time, different wear mechanisms have been studied to develop improved grades of cemented carbide with high wear resistance properties. The research is still continuing. Moreover, due to the highly unpredictable nature of coal/rock, it is not easy to understand the wear mechanisms. In the present work, an attempt has been made to understand the wear mechanisms in four conical picks, which were used in a continuous miner machine for underground mining of coal. The wearing pattern of the conical pick indicates damage in its cemented carbide tip as well as the steel body. The worn out parts of the tools have been critically examined using scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) point analysis. Mainly four types of wear mechanisms, namely, coal/rock intermixing, plastic deformation, rock channel formation and crushing and cracking, have been detected. The presence of coal/rock material and their respective concentrations in the selected area of worn out surface were observed using the spectra generated by EDX analysis.

  3. Psychosocial dysfunction associated with skin picking disorder and trichotillomania.

    Science.gov (United States)

    Grant, Jon E; Redden, Sarah A; Leppink, Eric W; Odlaug, Brian L; Chamberlain, Samuel R

    2016-05-30

    Skin picking disorder (SPD) and trichotillomania (TTM) are common and oftentimes disabling disorders. 125 Participants with SPD and 152 with TTM undertook clinical and neurocognitive evaluation, and were grouped according to mild, moderate, or severe levels of psychosocial dysfunction. Relationships between functional impairment and other variables were explored using linear regression and categorical analyses. Greater functional impairment was associated with worse disease severity in both groups, and by later symptom onset and lower quality of life in TTM subjects. These results indicate that levels of self-reported psychosocial dysfunction have a strong association with specific clinical aspects of SPD and TTM.

  4. Pick 'n' mix: neuropatholgical detection of peri-tumour taupathy.

    LENUS (Irish Health Repository)

    Lonergan, Roisin

    2013-11-01

    Radiotherapy is used to treat recurrent oligodendrogliomas, WHO grade 2 tumours. Potential morbitities include steroid-responsive radiation necrosis and radiation leucoencephalopathy, characterised pathologically by reactive astrogliosis, focal necrosis, demyelination, axonal loss, and clinically by progressive subcortical deficits (ataxia, amnesia, incontinence, cognitive decline), with relative sparing of cortical function. Although subcortical features may overlap with neurodegenerative conditions (eg frontotemporal dementia), focal cortical atrophy of FTD causes loss of language function in addition to memory, and specific histopathological features characterise FTD subtypes (eg Pick disease). Association between mitotic disease and tauopathy has not been reported widely, but co-existence is possible. Diagnostic accuracy may guide management.

  5. Niemann-Pick type C mutations cause lipid traffic jam.

    Science.gov (United States)

    Liscum, L

    2000-03-01

    The Niemann-Pick C protein (NPC1) is required for cholesterol transport from late endosomes and lysosomes to other cellular membranes. Mutations in NPC1 cause lysosomal lipid storage and progressive neurological degeneration. Cloning of the NPC1 gene has given us tools with which to investigate the function of this putative cholesterol transporter. Here, we discuss recent studies indicating that NPC1 is not a cholesterol-specific transport molecule. Instead, NPC1 appears to be required for the vesicular shuttling of both lipids and fluid-phase constituents from multivesicular late endosomes to destinations such as the trans-Golgi network.

  6. Skin picking disorder with co-occurring body dysmorphic disorder

    DEFF Research Database (Denmark)

    Grant, Jon E; Redden, Sarah A; Leppink, Eric W

    2015-01-01

    There is clinical overlap between skin picking disorder (SPD) and body dysmorphic disorder (BDD), but little research has examined clinical and cognitive correlates of the two disorders when they co-occur. Of 55 participants with SPD recruited for a neurocognitive study and two pharmacological...... studies, 16 (29.1%) had co-occurring BDD. SPD participants with and without BDD were compared to each other and to 40 healthy volunteers on measures of symptom severity, social functioning, and cognitive assessments using the Stop-signal task (assessing response impulsivity) and the Intra...

  7. A preliminary investigation of acceptance and commitment therapy as a treatment for chronic skin picking.

    Science.gov (United States)

    Twohig, Michael P; Hayes, Steven C; Masuda, Akihiko

    2006-10-01

    The effectiveness of a deliberately limited version of Acceptance and Commitment Therapy (ACT) for chronic skin picking was evaluated in a pair of multiple baseline across participants designs. Self-monitoring of skin picking showed that four of the five participants reached near zero levels of picking by post-treatment, but these gains were not fully maintained for three of the four participants at follow-up. The findings of the self-reported skin picking were generally corroborated by ratings of photographs of the damaged areas and by ratings on a validated measure of skin picking severity. All participants rated the intervention as socially acceptable, and reductions were found on measures of anxiety, depression, and experiential avoidance for most participants as a result of the intervention. Results support the construction of more comprehensive ACT protocols for skin picking.

  8. [Effects of debagging time and picking off leaf on fruit quality of "Red Fuji" apple].

    Science.gov (United States)

    Zhang, Ji-Xiang; Yue, Yu-Ling; Wei, Qin-Ping; Wang, Xiao-Wei; Zhang, Qiang

    2010-08-01

    This paper studied the effects of debagging time and picking off leaves around fruits on the fruit quality and 1-year old shoots stored nutrition of "Red Fuji" apple. Properly advancing debagging time significantly increased the mean mass, anthocyanin content, and coloration area of the fruits (P picked off, the light environment around the fruits improved significantly (P picked off treatment. Picking off the leaves within 30-45 cm away from the fruits benefited the fruit coloration and anthocyanin accumulation. No significant effects were observed on the 1-year old shoots stored nutrition and their budding in next year among the treatments of picking off leaves. Advancing debagging time and picking off the leaves within 30-45 cm away from the fruits could improve fruit appearance and quality.

  9. Study on pick arrangement of shearer drum based on load fluctuation

    Institute of Scientific and Technical Information of China (English)

    DU Chang-long; LIU Song-yong; CUI Xin-xia; LI Ti-jian

    2008-01-01

    According to the coal or rock cutting theory, a mechanical model and computing formula for a pick and the drum load fluctuation model were established in order to obtain relationships between pick arrangements and drum fluctuation loads, drum rotary speeds and haulage speeds. Based on a minimum load fluctuation, an optimal mathematical model was established for drum pick arrangements. The effects of pick arrangements (including punnett square, sequence, aberrance Ⅰ and Ⅱ) on the drum load fluctuation coefficient are discussed. The relationships between the pick arrangements of the drum with different start vanes and the cutting load fluctuation coefficient, the drum rotary speed and haulage speed were also studied. The results indicate that the punnett square arrangement has a smaller cutting load fluctuation coefficient than other forms of arrangement and the drum with the 4-start vanes has the smallest coefficient. The drum rotary speed and haulage speed are affected not only by pick arrangements, but also by the number of vanes.

  10. A Proposed Analytical Model for Integrated Pick-and-Sort Systems

    Directory of Open Access Journals (Sweden)

    Recep KIZILASLAN

    2013-11-01

    Full Text Available In this study we present an analytical approach for integration of order picking and sortation operations which are the most important, labour intensive and costly activity for warehouses. Main aim is to investigate order picking and sorting efficiencies under different design issues as a function of order wave size. Integrated analytical model is proposed to estimate the optimum order picking and order sortation efficiency. The model, which has been tested by simulations with different illustrative examples, calculates the optimum wave size that solves the trade-off between picking and sorting operations and makes the order picking and sortations efficiency maximum. Our model also allow system designer to predict the order picking and sorting capacity for different system configurations. This study presents an innovative approach for integrated warehouse operations.

  11. Evidence of Change of Intention in Picking Situations.

    Science.gov (United States)

    Furstenberg, Ariel; Breska, Assaf; Sompolinsky, Haim; Deouell, Leon Y

    2015-11-01

    Intending to perform an action and then immediately executing it is a mundane process. The cognitive and neural mechanisms involved in this process of "proximal" intention formation and execution, in the face of multiple options to choose from, are not clear, however. Especially, it is not clear how intentions are formed when the choice makes no difference. Here we used behavioral and electrophysiological measures to investigate the temporal dynamics of proximal intention formation and "change of intention" in a free picking scenario, in which the alternatives are on a par for the participant. Participants pressed a right or left button following either an instructive visible arrow cue or a visible neutral "free-choice" cue, both preceded by a masked arrow prime. The goal of the prime was to induce a bias toward pressing the left or right button. Presumably, when the choice is arbitrary, such bias should determine the decision. EEG lateralized readiness potentials and EMG measurements revealed that the prime indeed induced an intention to move in one direction. However, we discovered a signature of "change of intention" in both the Instructed and Free-choice decisions. These results suggest that, even in arbitrary choices, biases present in the neural system for choosing one or another option may be overruled and point to a curious "picking deliberation" phenomenon. We discuss a possible neural scenario that could explain this phenomenon.

  12. Refraction Static Correction without Picking First Arrival Times

    Directory of Open Access Journals (Sweden)

    Chien-Ying Wang

    2009-01-01

    Full Text Available A concept of differential delay time is proposed for refraction static correction without picking first arrival times in the CDP reflection data processing. This new method is a modification of the ABCD method; it uses cross-correlation to measure the first arrival time difference between signals received at stations B and C, instead of directly computing them from their picked times. By taking advantage of multiple-fold CDP data, we apply the "line-up trace" measurement of cross-correlations, which may alleviate the effect of data imperfections. The problem of refractor velocity variation has also been solved to a certain extent, which allows for a reliable delay time to be adequately estimated for each station and consequently the static correction value. A synthetic model and a real case with a severe weathered layer problem have been tested to evaluate the method. Stable and man age able computation processes have been explored to attain the maximum performance. The results are quite satisfactory. It should be possible to apply this method in rough areas with complicated refraction static problem, even in 3D cases.

  13. Feather-picking psittacines: histopathology and species trends.

    Science.gov (United States)

    Garner, M M; Clubb, S L; Mitchell, M A; Brown, L

    2008-05-01

    Histologic findings are described for 408 feather-picking or self-mutilating psittacines with the use of biopsies from clinically affected and unaffected skin. Inflammatory skin disease was diagnosed in 210 birds, and traumatic skin disease was diagnosed in 198 birds. Criteria used for the diagnosis of inflammatory skin disease included the presence of perivascular inflammation in the superficial or deep dermis of clinically affected and unaffected sites. The primary histologic criteria for the diagnosis of traumatic skin disease were superficial dermal scarring with or without inflammation in the affected sites and an absence of inflammation in the unaffected sites. The inflammatory cells associated with the lesions were typically lymphocytes and occasionally plasma cells, histiocytes, and granulocytes. A preponderance of inflammatory skin disease was seen in macaws (Ara spp.) and Amazon parrots (Amazona spp.). A preponderance of traumatic skin disease was seen in cockatoos (Cacatua spp.) and African grey parrots (Psittacus erithacus). The prevalence of each was approximately equal in several other species, including conures (Aratinga and Pyrrhura spp.), eclectus parrots (Eclectus roratus), quaker parrots (Myiopsitta monachus), cockatiels (Nymphicus hollandicus), parakeets (Cyanorhamphus and Psittacula spp.), and caiques (Pionites spp.). No geographic or gender-based trends were identified. These findings could be helpful for identifying and treating birds with feather-picking disorders.

  14. How consumers pick a hotel strategic segmentation and target marketing

    CERN Document Server

    Winston, William

    2013-01-01

    Venture through the pages of How Consumers Pick a Hotel to learn the steps of selecting a target and using consumer behavior applications to segment the market to reach your target. Much as a consumer goes through the process of selecting a satisfying hotel, you can choose to use the information provided to make your hospitality career relaxing and satisfying. When you finish this fantastic reading journey, you'll be prepared to offer services that meet the public's demands, and you'll possess the prerequisite knowledge and skills for developing your own strategic approach to a target market. As the many methods of segmentation are discussed in detail, you will also learn effective strategies for communicating with multiple segments. Ideal as a supplementary text for marketing and hospitality marketing courses, How Consumers Pick a Hotel provides a concise overview of consumer behavior and intertwines marketing theory with sound ways in which to implement the theory. This will both orient you and give you a s...

  15. [Assessment for intelligence on patients with Pick's disease].

    Science.gov (United States)

    Nagano, K; Tanabe, H; Kazui, H; Ikeda, M; Hashimoto, M; Yamada, N; Nakagawa, Y; Nishimura, T

    1995-11-01

    In contrast to Alzheimer's disease, it is unclear whether the MMS (Mini-Mental State) or the RCPM (Raven's Coloured Progressive Matrices) is clinically useful as a mental test battery in patients with Pick's disease, and it has not been fully evaluated whether intelligence of these patients really deteriorate along with the staging of dementia. The present study aimed to make these problems clear. We administered the MMS and the RCPM to 17 cases of Pick's disease, including 7 cases with predominantly frontal lobe atrophy and 10 cases with predominantly temporal lobe atrophy, which were all classified into 3 groups according to the staging of dementia by using the NM scale (New Clinical Scale for Rating of Mental States). We also investigated whether these patients had "Denkfaulheit" (laziness of thinking) and/or "gogi" aphasia (word meaning aphasia), which may affect performances on the mental test batteries. Two cases with predominantly frontal lobe atrophy and 5 cases with predominantly temporal lobe atrophy were assessed by the same examinations several years later. In cases with predominantly frontal lobe atrophy, all the patients presented with "Denkfaulheit". However, the mean RCPM score was normal in the mildly damaged patients, suggesting that their intelligence were relatively preserved. In the moderately and severely damaged groups, their intelligence could not be assessed owing to their severe "Denkfaulheit". In cases with predominantly temporal lobe atrophy, all the patients had "gogi" aphasia and 3 cases of the severely damaged groups presented with "Denkfaulheit".(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Comparative study of the radial and tangential shearer cutting picks from an energetic point of view

    Energy Technology Data Exchange (ETDEWEB)

    Marian, I.; Elczner, G.; Kovacs, I.; Koronka, F.

    1984-11-01

    After having calculated and established the deformation energies of radial and tangential shearer cutting picks by laboratory test, it is concluded that in the conditions specific for the lignite operations in Romania the tangential type of picks, among many other advantages, ensure important energy savings. The tests were aimed at improving the parameters and construction of the shearer cutting picks and at increasing their cutting efficiency. 4 references.

  17. Experiment on Conical Pick Cutting Rock Material Assisted with Front and Rear Water Jet

    OpenAIRE

    Xiaohui Liu; Songyong Liu; Lie Li; Xinxia Cui

    2015-01-01

    Conical picks are one kind of cutting tools widely used in engineering machinery. In the process of rock breaking, the conical pick bears great cutting force and wear. To solve the problem, a new method, conical pick assisted with high pressure water jet, could break rock effectively, and four different configuration modes of water jet were presented. In this paper, based on the analysis of the different water jet configuration’s advantages and disadvantages, experiments on front water jet, n...

  18. Pick-Up Ion Instabilities at Planetary Magnetospheres

    Science.gov (United States)

    Strangeway, Robert J.; Sharber, James (Technical Monitor)

    2001-01-01

    This effort involved the analysis of low frequency waves as observed by the Galileo spacecraft near the Galilean moon, Io. Io is a significant source of material, especially SO2, and various products of dissociation, and further these atoms and molecules are readily ionized. The initial velocity of the ions is essentially that of the neutral species, i.e., the Keplerian velocity. The plasma, on the other hand is co-rotating, and there is a differential flow of the order 57 km/s between the plasma and the neutral particles. Thus pick-up ion instabilities are Rely to occur within the Jovian magnetosphere. Indeed, magnetometer observations from the Galileo spacecraft clearly show ion cyclotron waves that have been identified with a large variety of plasma species, such as O+, S++ (which has the same gyro-frequency as O+), S+, and SO2+. Typically, however, the dominant frequency is near the SO2+ gyro-frequency. The research effort was originally planned to be a team effort between Robert J. Strangeway as the Principal Investigator, and Debbie Huddleston, who was an Assistant Research Geophysicist at UCLA. Unfortunately, Dr. Huddleston took a position within Industry. The effort was therefore descoped, and Dr. Strangeway instead pursued a collaboration with Dr. Xochitl Blanco-Cano, of the Instituto de Geofisica, Universidad Nacional Autonoma de Mexico. This has proved to be a productive collaboration, with several papers and publications arising out of the effort. The magnetic field oscillations near lo generally fall into two types: ion cyclotron waves, with frequencies near an ion gyro-frequency, and lower frequency mirror-mode waves. The ion cyclotron waves are mainly transverse, and frequently propagate along the ambient magnetic field. The mirror-mode waves are compressional waves, and they have essentially zero frequency in the plasma rest frame. One of the purposes of our investigation is to understand what controls the types of wave modes that occur, since both

  19. Global electricity company profiles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    Global Electricity Company Profiles examines the operations and strategies of 60 of the leading electricity companies in the world. Through its analysis of the key players, the report provides a comprehensive review of the current state of the global electricity industry. Using electricity sales as its criteria, the most successful companies are compared in terms of their national, regional and global importance. Global Electricity Company Profiles provides an outline of each company, its structure and operations, as well as key financial data. The detailed performance benchmarking and review of expectations for future development for each individual company provide a wealth of invaluable strategic information not available elsewhere. (author)

  20. Childhood-onset pathologic skin picking: clinical characteristics and psychiatric comorbidity.

    Science.gov (United States)

    Odlaug, Brian L; Grant, Jon E

    2007-01-01

    There has been little research examining clinical correlates of childhood-onset pathologic skin picking in a sample of individuals with a primary diagnosis of pathologic skin picking. Using a sample of 40 consecutive subjects with current pathologic skin picking, we compared subjects with childhood-onset (before 10 years of age) pathologic skin picking to those with later onset on a variety of clinical measures. Symptom severity was examined by assessing time spent picking per day, intensity and frequency of thoughts and urges to pick, and social and occupational functioning. Of the 40 subjects, 19 (47.5%) reported onset of skin picking before 10 years of age. Subjects with childhood-onset had significantly longer durations of illness before receiving treatment and were more likely to pick unconsciously. Symptom severity, comorbidity, and social functioning did not differ between groups. These preliminary results suggest that although onset before 10 years of age is fairly common among people with pathologic skin picking, individuals developing this behavior earlier in life have similar clinical characteristics as those with later onset but may be less likely to seek treatment.

  1. An order-picking operations system for managing the batching activities in a warehouse

    Science.gov (United States)

    Lam, Cathy H. Y.; Choy, K. L.; Ho, G. T. S.; Lee, C. K. M.

    2014-06-01

    Nowadays, customer orders with high product variety in small quantities are often received and requested for timely delivery. However, the order-picking process is a labour-intensive and costly activity to handle those small orders separately. In such cases, small orders are often grouped into batches so that two or more orders can be served at once to increase the picking efficiency and thus reduce the travel distance. In this paper, an order-picking operations system (OPOS) is proposed to assist the formulation of an order-picking plan and batch-handling sequence. The study integrates a mathematical model and fuzzy logic technique to divide the receiving orders into batches and prioritise the batch-handling sequence for picking, respectively. Through the proposed system, the order-picking process can be managed as batches with common picking locations to minimise the travel distance, and the batch-picking sequence can be determined as well. To demonstrate the use of the system, a case study in a third-party logistics warehouse is presented, and the result shows that both the order-picking activity and labour utilisation can be better organised.

  2. Picking vs Waveform based detection and location methods for induced seismicity monitoring

    Science.gov (United States)

    Grigoli, Francesco; Boese, Maren; Scarabello, Luca; Diehl, Tobias; Weber, Bernd; Wiemer, Stefan; Clinton, John F.

    2017-04-01

    Microseismic monitoring is a common operation in various industrial activities related to geo-resouces, such as oil and gas and mining operations or geothermal energy exploitation. In microseismic monitoring we generally deal with large datasets from dense monitoring networks that require robust automated analysis procedures. The seismic sequences being monitored are often characterized by very many events with short inter-event times that can even provide overlapped seismic signatures. In these situations, traditional approaches that identify seismic events using dense seismic networks based on detections, phase identification and event association can fail, leading to missed detections and/or reduced location resolution. In recent years, to improve the quality of automated catalogues, various waveform-based methods for the detection and location of microseismicity have been proposed. These methods exploit the coherence of the waveforms recorded at different stations and do not require any automated picking procedure. Although this family of methods have been applied to different induced seismicity datasets, an extensive comparison with sophisticated pick-based detection and location methods is still lacking. We aim here to perform a systematic comparison in term of performance using the waveform-based method LOKI and the pick-based detection and location methods (SCAUTOLOC and SCANLOC) implemented within the SeisComP3 software package. SCANLOC is a new detection and location method specifically designed for seismic monitoring at local scale. Although recent applications have proved an extensive test with induced seismicity datasets have been not yet performed. This method is based on a cluster search algorithm to associate detections to one or many potential earthquake sources. On the other hand, SCAUTOLOC is more a "conventional" method and is the basic tool for seismic event detection and location in SeisComp3. This approach was specifically designed for

  3. Titan's atmospheric sputtering and neutral torus produced by magnetospheric and pick-up ions

    Science.gov (United States)

    Michael, M.; Smith, H. T.; Johnson, R. E.; Shematovich, V.; Leblanc, F.; Ledvina, S.; Luhmann, J. H.

    As Titan does not possess an intrinsic magnetic field, Kronian magnetospheric ions can penetrate Titan's exobase as can locally produced pick-up ions (e.g. Shematovich et al. 2003). This can cause atmospheric loss and heating of the exobase region. Penetration by slowed and deflected magnetospheric ions and by the pick-up ions is described here using a 3-D Monte Carlo model (Michael et al. 2004). The incident ions can lead to the production of fast neutrals that collide with other atmospheric neutrals producing the ejection of both atomic and molecular nitrogen and heating. The recently calculated dissociation cross sections of N2 are used in the present model (Tully and Johnson 2002). The incident flux of slowed magnetospheric N+ ions and pick-up C2H5+ ions is estimated from the work of Brecht et al. (2000). These ions, which have energies less than 1.2 keV, were shown to be more efficient in ejecting material from Titan's atmosphere than the non-deflected co-rotating ions used earlier (Lammer et al. 1993). The loss rates are comparable or larger than those produced by photo-dissociation. Exobse heating rates are given and the loss rates of N and N2 are then used as a source of nitrogen for the Titan neutral torus. If atmospheric sputtering is important this torus will contain both atomic and molecular nitrogen and, therefore, will provide a distributed source of both atomic and molecular nitrogen ions that will be readily detected by Cassini (Smith et al. 2004) Acknowledgment: This work is supported by NASA's Planetary Atmospheres Program and by the CAPS-Cassini Instrument. Brecht, S.H., J.G. Luhmann, and D.J. Larson, J. Geophys. Res., 105, 13119, 2000. Lammer, H., and S.J. Bauer,. Planet. Space Sci., 41, 657, 1993. Shematovich, V.I.,et al, J. Geophys. Res., 108, 5086, 10.1029/2003JE002096, 2003. Michael, M. et al., submitted, Icarus, 2004. Smith, H.T., et al., Titan Aeronomy Workshop, Paris, January 7-9, 2004. Tully, C., R.E. Johnson, J. Chem. Phys. 117, 6556

  4. LA CREACION DE EMPRESAS DE ECONOMIA SOCIAL EN EL MODELO DE DESARROLLO LOCAL: REFLEXIONES SOBRE LA DIVERGENCIA ACTUAL DEL CASO VALENCIANO / THE CREATION OF SOCIAL ECONOMY COMPANIES IN THE MODEL OF LOCAL DEVELOPMENT: REFLECTIONS ON THE PRESENT CASE VALENCIAN DIVERGENCE

    Directory of Open Access Journals (Sweden)

    RICARD CALVO PALOMARES

    2011-05-01

    Full Text Available La hipótesis central de nuestro artículo gira en torno al papel asumido por el modelo de desarrollo local implantado en España desde la década de los 80 en el proceso de creación de empresas, y en concreto en el proceso de creación de empresas de Economía Social. Plantea la reflexión sobre cómo en sus inicios el modelo, apostaba encarecidamente por el fomento y la constitución de cooperativas como política activa de empleo, y en cómo en la actualidad, ha abandonado esta línea de actuación en favor de otras formas jurídicas. Para ello, partiremos del análisis de los datos oficiales existentes sobre la evolución de los dos modelos en la Comunitat Valenciana, poniendo de manifiesto la tendencia a la baja sufrida en la promoción de constitución de entidades de Economía Social y por el contrario el continuo crecimiento de Agencias Locales de Empleo y Desarrollo. Finalmente concluiremos el artículo proponiendo una serie de factores, que a nuestro entender han sido los determinantes de este proceso. / The central hypothesis of this article focuses on the role played by the local development model implemented in Spain since the 80//////s in the process of business creation, and specifically in the creation of social economy enterprises. Raises the debate on how the model in its infancy, argued strongly for the promotion and development of cooperatives as active employment policy, and how at present, has abandoned this line of action in favor of other legal forms. For this, the analysis of existing official data on the evolution of the two models in the Valencia region, shown by the downward trend experienced in the promotion of cooperatives and on the contrary, the continuous growth of Local Agencies Employment and Development. Finally propose a number of factors, which we believe are the determinants of this process.

  5. WaVPeak: Picking NMR peaks through wavelet-based smoothing and volume-based filtering

    KAUST Repository

    Liu, Zhi

    2012-02-10

    Motivation: Nuclear magnetic resonance (NMR) has been widely used as a powerful tool to determine the 3D structures of proteins in vivo. However, the post-spectra processing stage of NMR structure determination usually involves a tremendous amount of time and expert knowledge, which includes peak picking, chemical shift assignment and structure calculation steps. Detecting accurate peaks from the NMR spectra is a prerequisite for all following steps, and thus remains a key problem in automatic NMR structure determination. Results: We introduce WaVPeak, a fully automatic peak detection method. WaVPeak first smoothes the given NMR spectrum by wavelets. The peaks are then identified as the local maxima. The false positive peaks are filtered out efficiently by considering the volume of the peaks. WaVPeak has two major advantages over the state-of-the-art peak-picking methods. First, through wavelet-based smoothing, WaVPeak does not eliminate any data point in the spectra. Therefore, WaVPeak is able to detect weak peaks that are embedded in the noise level. NMR spectroscopists need the most help isolating these weak peaks. Second, WaVPeak estimates the volume of the peaks to filter the false positives. This is more reliable than intensity-based filters that are widely used in existing methods. We evaluate the performance of WaVPeak on the benchmark set proposed by PICKY (Alipanahi et al., 2009), one of the most accurate methods in the literature. The dataset comprises 32 2D and 3D spectra from eight different proteins. Experimental results demonstrate that WaVPeak achieves an average of 96%, 91%, 88%, 76% and 85% recall on 15N-HSQC, HNCO, HNCA, HNCACB and CBCA(CO)NH, respectively. When the same number of peaks are considered, WaVPeak significantly outperforms PICKY. The Author(s) 2012. Published by Oxford University Press.

  6. On the Trend of the Innovation Cooperation between the Multinational Company and Local Enterprise%跨国公司与本土企业创新合作趋势研究

    Institute of Scientific and Technical Information of China (English)

    简徳三; 杨晔; 刘曦腾

    2016-01-01

    The cooperation between the multinational company and the local enterprise has been an important part of global economic integration, and both sides benefit from the cooperation of global economic integration.In the future, China will continue to be the most attractive area of multinational corporations, but the strategic cooperation needs, the trend and the pattern have had significant changes.In this regard, China must grasp this opportunity to adjust the formu-lation of relevant policies.%跨国公司与本土企业的合作是经济全球化的重要组成部分, 中国和跨国公司双方受益于国际经济合作, 未来中国对跨国公司仍将是最具吸引力的区域, 但双方战略合作需求点、 趋势和模式已有了新变化, 中国必须因势利导调整制定相关的政策.

  7. Pseudohyperglycaemia in a comatose patient after picking cherries.

    Science.gov (United States)

    Derkenne, Clément; Lamblin, Antoine; Jost, Daniel; Tourtier, Jean-Pierre

    2016-10-28

    We report a case of pseudohyperglycaemia on a capillary blood glucose measurement taken from fingers stained with sugar (fructose). A 76-year-old patient with type 1 diabetes received emergency attention at home because of a coma. The first capillary blood glucose measurement collected from a finger revealed a concentration higher than the reference limits, misleading the clinician. After starting symptomatic treatment, a second blood glucose measurement was taken. This measurement, taken at the earlobe, revealed profound hypoglycaemia (0.89 mmol/L), which prompted the administration of appropriate treatment. The elevated initial capillary blood glucose measurement was linked to the presence of fructose on the fingers of the patient from picking cherries just before the patient fainted. After intravenous administration of glucose, the patient regained normal consciousness and had no sequelae despite the severity of the hypoglycaemia and delayed diagnosis. Pseudohyperglycaemia is rare, and delayed diagnosis frequently results in severe sequelae or death.

  8. Alternative Therapies for Excoriation (Skin Picking) Disorder: A Brief Update.

    Science.gov (United States)

    Torales, Julio; Barrios, Iván; Villalba, Jorge

    2017-01-01

    Context • Excoriation (skin picking) disorder is characterized by the need or urge to pick, scratch, pinch, touch, rub, scrub, squeeze, bite, or dig the skin, and it can be a perplexing condition for the inexperienced physician. Treatments include pharmacotherapy, psychotherapy, and alternative therapies. Alternative therapies for excoriation disorder and other body-focused repetitive behaviors include yoga, aerobic exercise, acupuncture, biofeedback, hypnosis, and inositol and N-acetylcysteine, among others. Objective • This review article intended to review the current literature on the alternative therapies to provide a brief update on their benefits for the treatment of excoriation disorder for use in conjunction with psychotherapy and pharmacotherapy in the management of a challenging group of patients. Design • This review (focusing on literature published in the last 15 y, selected from a search of PubMed) critically considers the evidence for the use of alternative therapies in the treatment of excoriation disorder. Setting • This review was conducted at the National University of Asunción (San Lorenzo, Paraguay). Results • Results for yoga were as follows: This technique may influence the structure and functioning of the areas of emotional processing involved in the pathophysiology of excoriation disorder and other body-focused repetitive behaviors, such as trichotillomania. Although still limited, the current research team's use of yoga as a treatment has given useful results. Results for aerobic exercise were as follows: People suffering from excoriation disorder and other-body focused repetitive behaviors generally have a worsening of their behaviors in times of negative mood and anxiety. As exercise has qualities that allow individuals to improve their mood and reduce their anxiety, it is likely that it also can help reduce behaviors like hair pulling or scratching, and it should be considered to be an adjunctive therapy. Results for

  9. Picking and Nibbling in Children and Adolescents with Eating Disorders

    Science.gov (United States)

    Kass, Andrea E.; Accurso, Erin C.; Goldschmidt, Andrea B.; Anam, Seeba; Byrne, Catherine E.; Kinasz, Kate; Goodyear, Alexandria; O'Brien, Setareh; Le Grange, Daniel

    2016-01-01

    Objective Picking and nibbling (P&N), defined as eating in an unplanned and repetitious way between meals and snacks, is prevalent among adults with eating disorders (EDs), but unexamined among youth with EDs. This study sought to assess the prevalence of P&N in youth with EDs and its association with ED and comorbid pathology. Method Youth (N = 515; ages 7–18) who presented to one outpatient ED research-clinical program were assessed for ED and comorbid pathology. Results Two-fifths (n = 214, 41.6%) of youth endorsed P&N. These individuals were older (p .05). Discussion Consistent with research in adults, P&N is prevalent but not significantly associated with ED pathology, except for global ED pathology in youth with AN/atypical AN, or comorbid disorders. PMID:26282064

  10. Design of Nut Picked Platform in Hill Country

    Directory of Open Access Journals (Sweden)

    Jian Zhou

    2014-10-01

    Full Text Available The subject target is to design agricultural production facility. Hydraulic lifting platform consists of high quality steel, hydraulic pumps, fluid cylinders, tubing, rail wheels and other combinations. The hydraulic lifting table of maximum load is 500 kg, The lifting table is composed of two parts: Mechanism body and hydraulic system. Lifting operation and controlling system are done by a hydraulic system and hydraulic cylinders, all combinations of hydraulic system are driven by hydraulic pump. Hydraulic pump and hydraulic cylinder mainly belong to standard components. The affected maximum force of fluid cylinder is analyzed through supporting hinge frame for raising goods, torque of lifting platform is also calculated, liquid system is also studied carefully. Through comparing and checking the relative datum, the design can satisfy the demand of picking fruits.

  11. Excoriation (skin picking) disorder in Israeli University students

    DEFF Research Database (Denmark)

    Leibovici, Vera; Murad, Sari; Cooper-Kazaz, Rena

    2014-01-01

    , depression, obsessive-compulsive disorder, body dysmorphic disorder and disruptive, impulse control and conduct disorders. A total of 2176 participants (43.6%) responded and were included in the analysis. Mean age was 25.1 ± 4.8 (range 17-60) years, and 64.3% were female. RESULTS: The proportion of students...... who were screened positive for SPD was 3.03%, with a nearly equal gender distribution (3.0% in females and 3.1% in males). There was a trend toward significantly higher rates of psychiatric problems such as generalized anxiety, compulsive sexual behavior and eating disorders in these students. Within......OBJECTIVE: The purpose of the study was to examine the prevalence of excoriation (skin picking) disorder (SPD) and associated physical and mental health correlates in a sample of Israeli university students. METHODS: Five thousand Israeli students were given questionnaires screening for SPD...

  12. A case of Niemann – Pick disease type C

    Directory of Open Access Journals (Sweden)

    Sergei Anatolyevich Klyushnikov

    2013-01-01

    Full Text Available The paper describes a clinical case of a 27-year-old female patient with Niemann – Pick disease type C (NPC, a rare inherited orphan disease, belonging to a group of lipid storage diseases. It gives an update on the etiology and pathogenesis of this type of glycosphingolipidosis and on established gene mutations. The clinical polymorphism of NPC and the trends in the development of somatic, mental, and neurological disorders are highlighted in relation to the onset age of the disease. The problem of differential diagnosis is discussed. The diagnostic NPC probability index in scores and the latest methods for laboratory diagnostic verification, including molecular genetic testing, are presented.Information is given on specific substrate reduction therapy with miglustat for NPC.

  13. [Niemann-Pick type C disease: pathophysiology, diagnosis and treatment].

    Science.gov (United States)

    Ohno, Kousaku

    2016-03-01

    Niemann-Pick type C (NPC) disease is an autosomal recessive neurodegenerative disorder which is caused in 95% by a mutation in the NPC1 gene on chromosome 18 or by NPC2 mutation, encoding for 2 different lysosomal lipid transport proteins. The impaired protein function leads to systemic intralysosomal accumulation of free cholesterol and shingolipids particularly in the CNS. In Japan, currently 34 living NPC patients are known as of December 2015. Considering the prevalence of the disease in the Western countries, the real number of NPC patients is most likely to be five-folds higher. For NPC, treatment methods are established and an approved disease-specific medications are available. It is important that patients early in their disease are referred to expert centers, in order to ensure timely initiation of treatment and to delay the progression of neurological symptoms as a goal.

  14. MERGER ACCOUTING FOR COMPANIES

    Directory of Open Access Journals (Sweden)

    SUCIU GHEORGHE

    2014-05-01

    Full Text Available Companies, especially nowadays, are characterized through great mobility, fast circulation of capital, occurring in their chase for profit. In this context, companies look for alliances, economical and political assistance. These objectives can materialize through merging of companies. The merger can be internal (between Romanian companies or transboundary, which includes foreign companies. In order to correctly reflect these events, the merger operations must be regulated and must respect national and international regulations. One important request concerning the merger operations is that the accounting values of the assets, debts and ownership equity must be brought to the present financial value.

  15. Local Transport Policy and Planning

    DEFF Research Database (Denmark)

    Hansen, Carsten Jahn

    The Ph. D. thesis describes and analyses how environmental obejctives and strategies have materialised in the real-life context of local transport policies and plans, how environmental perspectives have been picked up by policy makers concerned with transport issues, how policy and planning...

  16. Local Transport Policy and Planning

    DEFF Research Database (Denmark)

    Hansen, Carsten Jahn

    The Ph. D. thesis describes and analyses how environmental obejctives and strategies have materialised in the real-life context of local transport policies and plans, how environmental perspectives have been picked up by policy makers concerned with transport issues, how policy and planning...

  17. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.

    Science.gov (United States)

    Lu, Wei; Ziff, Edward B

    2005-08-04

    PICK1 and ABP/GRIP bind to the AMPA receptor (AMPAR) GluR2 subunit C terminus. Transfer of the receptor from ABP/GRIP to PICK1, facilitated by GluR2 S880 phosphorylation, may initiate receptor trafficking. Here we report protein interactions that regulate these steps. The PICK1 BAR domain interacts intermolecularly with the ABP/GRIP linker II region and intramolecularly with the PICK1 PDZ domain. Binding of PKCalpha or GluR2 to the PICK1 PDZ domain disrupts the intramolecular interaction and facilitates the PICK1 BAR domain association with ABP/GRIP. Interference with the PICK1-ABP/GRIP interaction impairs S880 phosphorylation of GluR2 by PKC and decreases the constitutive surface expression of GluR2, the NMDA-induced endocytosis of GluR2, and recycling of internalized GluR2. We suggest that the PICK1 interaction with ABP/GRIP is a critical step in controlling GluR2 trafficking.

  18. Behavioral Treatment of Chronic Skin-Picking in Individuals with Developmental Disabilities: A Systematic Review

    Science.gov (United States)

    Lang, Russell; Didden, Robert; Machalicek, Wendy; Rispoli, Mandy; Sigafoos, Jeff; Lancioni, Giulio; Mulloy, Austin; Regester, April; Pierce, Nigel; Kang, Soyeon

    2010-01-01

    Skin-picking is a type of self-injurious behavior involving the pulling, scratching, lancing, digging, or gouging of one's own body. It is associated with social impairment, and increased medical and mental health concerns. While there are several reports showing that skin-picking is common in individuals with developmental disabilities, knowledge…

  19. 教你正确用(三)Pick Up的十种用法

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ I have been wondering about the number of ways we can use the expression "pick up" in everyday English. Today,sitting through a long,boring meeting,I took some notes. I counted at least 10 ways to use "pick up". In each case,the meaning of the expression is somewhat different.

  20. INTRAOPERATIYE OVUM PICK-UP AND ULTRASONICGUIDED TRANSVAGINAL OVUM RETRIEVAL IN AN IVF PROGRAM

    Institute of Scientific and Technical Information of China (English)

    ZHANGLi-Zhu; CHENGui-An; ZHAOWen-Xin; WANGZe-Mi; LIMei-Zhi; LIUPing; WANGXiu-Yun; ZHAOYun-Fen

    1989-01-01

    Methods of ovum pick-up in an IVF program From January to November, 1988, were reported. In the initial stages of the program, transabdominal intraopcrative ovum pick-up was used, which resulte, d in two cases of clinical pregnancy in 1987 with full term delivery

  1. Schwarz-Pick estimates for positive real part holomorphic functions on unit ball and polydisc

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    We give higher order derivatives Schwarz-Pick estimates for all positive real part holomorphic functions on Bn and D n,and generalize early work on Schwarz-Pick estimate of higher order derivatives for holomorphic functions with positive real part on unit disk in C.

  2. The high order Schwarz-Pick lemma on complex Hilbert balls

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper we prove a high order Schwarz-Pick lemma for holomorphic mappings between unit balls in complex Hilbert spaces.In addition,a Schwarz-Pick estimate for high order Fréchet derivatives of a holomorphic function f of a Hilbert ball into the right half-plane is obtained.

  3. Prevalence and heritability of skin picking in an adult community sample: a twin study.

    Science.gov (United States)

    Monzani, Benedetta; Rijsdijk, Fruhling; Cherkas, Lynn; Harris, Juliette; Keuthen, Nancy; Mataix-Cols, David

    2012-07-01

    Skin-picking disorder (SPD) is a disabling psychiatric condition that can lead to skin damage and other medical complications. Epidemiological data is scarce and its causes are unknown. The present study examined the prevalence and heritability of skin-picking symptoms in a large sample of twins. A total of 2,518 twins completed a valid and reliable self-report measure of skin-picking behavior. The prevalence of clinically significant skin picking was established using empirically derived cut-offs. Twin modeling methods were employed to decompose the variance in the liability to skin picking into additive genetic and shared and non-shared environmental factors. A total of 1.2% of twins scored above the cut-off, indicative of clinically significant skin picking. All these participants were women. Univariate model-fitting analyses (female twins only, N = 2,191) showed that genetic factors accounted for approximately 40% (95% CI 19-58%) of the variance in skin picking, with non-shared environmental factors and measurement error accounting for the remaining variance (60% [95% CI 42-81%]). Shared environmental factors were negligible. It is concluded that pathological skin picking is relatively prevalent problem, particularly among women, and that it tends to run in families primarily due to genetic factors. Non-shared environmental factors are also likely to play an important role in its etiology.

  4. SCHWARZ-PICK ESTIMATES FOR BOUNDED HOLOMORPHIC FUNCTIONS ON CLASSICAL DOMAINS

    Institute of Scientific and Technical Information of China (English)

    Liu Yang; Chen Zhihua

    2011-01-01

    In this paper,Schwarz-Pick estimates for high order Fréchet derivatives of bounded holomorphic functions on three kinds of classical domains are presented.We generalize the early work on Schwarz-Pick estimates of higher order partial derivatives for bounded holomorphic functions on the disk and unit ball.

  5. Treatment of Chronic Skin-Picking in an Adolescent With Asperger Syndrome and Borderline Intellectual Disability

    NARCIS (Netherlands)

    Lang, R.; Didden, H.C.M.; Sigafoos, J.; Rispoli, M.; Regester, A.; Lancioni, G.E.

    2009-01-01

    We present the case of a 17-year-old girl with Asperger syndrome and borderline intellectual disability with a 5-year history of chronic skin-picking. Our intervention approach included an initial functional assessment to identify variables maintaining skin-picking, followed by evaluation of a

  6. Treatment of Chronic Skin-Picking in an Adolescent With Asperger Syndrome and Borderline Intellectual Disability

    NARCIS (Netherlands)

    Lang, R.; Didden, H.C.M.; Sigafoos, J.; Rispoli, M.; Regester, A.; Lancioni, G.E.

    2009-01-01

    We present the case of a 17-year-old girl with Asperger syndrome and borderline intellectual disability with a 5-year history of chronic skin-picking. Our intervention approach included an initial functional assessment to identify variables maintaining skin-picking, followed by evaluation of a behav

  7. How 'ground-picked' olive fruits affect virgin olive oil ethanol content, ethyl esters and quality.

    Science.gov (United States)

    Beltran, Gabriel; Sánchez, Raquel; Sánchez-Ortiz, Araceli; Aguilera, Maria P; Bejaoui, Mohamed A; Jimenez, Antonio

    2016-08-01

    Olives dropped on the ground naturally sometimes are not separated from those fresh and healthy collected from the tree for harvest and processing. In this work we compared the quality, ethanol content and bioactive components of virgin olive oils from ground-picked olives, tree-picked fruits and their mixture. Ground-picked olives produced 'Lampante' virgin olive oils; these are of a lower quality category, because of important alterations in chemical and sensory characteristics. Ethyl esters showed the highest values, although under the regulated limit. The mixture of ground and tree-picked olives gave oils classified as 'virgin' because of sensory defects, although the quality parameters did not exceed the limits for the 'extra' category. Ethanol content showed a significant increase in the oils from ground- picked olives and their mixture with respect to those from tree-picked fruits. Furthermore, bioactive compounds showed a significant decrease as fruit quality was poorer. Ground-picked olives must be harvested and processed separately since they produce low-quality virgin olive oils with sensory defects and lower concentrations of bioactive compounds. The higher acidity and ethanol concentration observed in oils from ground-picked fruits or their mixture may help ethyl ester synthesis during storage. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

  8. Two new species of Anastrepha Schiner (Diptera, Tephritidae) closely related to Anastrepha pickeli Lima.

    Science.gov (United States)

    Canal, N A; Uramoto, K; Zucchi, R A

    2013-02-01

    Anastrepha entodonta n. sp. and Anastrepha hadropickeli n. sp. are described and illustrated. The new species belong to the spatulata group. Both species occur sympatrically with Anastrepha pickeli Lima in the semiarid region of the state of Minas Gerais, Brazil. Anastrepha hadropickeli occurs also in the semiarid of the state of Rio Grande do Norte, Brazil, where it was misidentified as A. pickeli.

  9. Efficacy of the “pick and roll” offense in top level European basketball teams

    Directory of Open Access Journals (Sweden)

    Marmarinos Christos

    2016-06-01

    Full Text Available Team offense in basketball games consists of a set of offensive actions carried out with the cooperation of two or more players. Of these actions, the most commonly used in the last decade is the on-ball screen called the “pick and roll.” The aim of this study was to analyze all of the pick and rolls conducted in the Euroleague championship from all of the 24 participating teams and to investigate the possible relationships between success in the pick and roll and overall success of the teams. For this purpose, 12,376 pick and rolls from 502 matches were analyzed and classified in categories according to the end result of the offensive possession. The results showed that the most effective type of pick and roll offense was when a shot was attempted after 2 passes from the pick and roll occurrence, followed by the screener’s shot when he rolled to the basket. Additionally, linear regression analysis confirmed that pick and roll effectiveness could predict the final classification of the teams. Conclusively, coaches of the high level European clubs should focus on training the players to the most efficient phases of the pick and roll offense, so that the chances of winning the championship to be maximized.

  10. Treatment of Chronic Skin-Picking in an Adolescent With Asperger Syndrome and Borderline Intellectual Disability

    NARCIS (Netherlands)

    Lang, R.; Didden, H.C.M.; Sigafoos, J.; Rispoli, M.; Regester, A.; Lancioni, G.E.

    2009-01-01

    We present the case of a 17-year-old girl with Asperger syndrome and borderline intellectual disability with a 5-year history of chronic skin-picking. Our intervention approach included an initial functional assessment to identify variables maintaining skin-picking, followed by evaluation of a behav

  11. Rock Breaking by Conical Pick Assisted with High Pressure Water Jet

    Directory of Open Access Journals (Sweden)

    Liu Songyong

    2014-03-01

    Full Text Available In the process of hard rock breaking, the conical pick bears great cutting force and wear, and the cutting efficiency is lower. Thus different combination ways of water jet and conical pick were proposed to solve this issue; for instance, water jet placed in the front of pick (JFP and water jet through the center of pick (JCP was researched by numerical simulation and experiments in this paper. First, the models of rock breaking were built based on SPH combined with finite element method. Then, the stress distribution of rock and the cut force of pick were analyzed when the rock broken by the conical pick assisted with the high pressure water jet. It indicates that the effect of the JCP on rock breaking is better than the JFP. At last, experiments about rock breaking with a conical pick and the JCP were conducted to verify the reliability of the simulation. It indicates that the rock breaking with the assistance of high pressure water jet cannot only reduce the pick force, but also increase the rock crushing volume.

  12. Performance of helical cutting drum with additional picks on the face side

    Energy Technology Data Exchange (ETDEWEB)

    Krauze, K.; Paraszczak, J. (University of Mining Metallurgy, Krakow (Poland))

    1990-01-01

    Extensive study has shown that it is necessary to apply additional picks to a shearer in order to eliminate or diminish the forces pushing it out of the coal face. The presented design of the cutting drum with three or four additional picks has met these conditions, and tests and observations have confirmed the value of this design. 4 figs., 1 tab.

  13. Behavioral treatment of chronic skin-picking in individuals with developmental disabilities: A systematic review

    NARCIS (Netherlands)

    Lang, R.; Didden, H.C.M.; Machalicek, W.A.; Rispoli, M.; Sigafoos, J.; Lancioni, G.E.; Mulloy, A.; Regester, A.; Pierce, N.; Kang, S.Y.

    2010-01-01

    Skin-picking is a type of self-injurious behavior involving the pulling, scratching, lancing, digging, or gouging of one's own body. It is associated with social impairment, and increased medical and mental health concerns. While there are several reports showing that skin-picking is common in indiv

  14. Expatriation on the strategy of internationalized companies

    Directory of Open Access Journals (Sweden)

    Shalimar Gallon

    2014-12-01

    Full Text Available This paper analyses the strategic role of the expatriation in the internationalization of the company. Expatriation should be minded as the result of a broader organizational strategy, representing one of the ways to articulate international and local strategies. A case study made on the Alpha Company has been presented in which 21 interviews were performed with professionals of the area and expatriates/repatriates. Alpha company has very emphasis in the world scenario and has a expatriation program of 12 years, nevertheless, has a lack of polices and more structured practices, due to its internationalization has been taken a larger dimension as the company was ready to deal with. It is pointed, however, that the same process have permitted several growing possibilities for professionals and the company as has presented many challenges to be overcome, like enhancement of the process training, repatriation planning, valorization and retention of the repatriate

  15. Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

    DEFF Research Database (Denmark)

    Madsen, Kenneth L; Beuming, Thijs; Niv, Masha Y

    2005-01-01

    PICK1 (protein interacting with C kinase 1) contains a single PDZ domain known to mediate interaction with the C termini of several receptors, transporters, ion channels, and kinases. In contrast to most PDZ domains, the PICK1 PDZ domain interacts with binding sequences classifiable as type I...... (terminating in (S/T)XPhi; X, any residue) as well as type II (PhiXPhi; Phi, any hydrophobic residue). To enable direct assessment of the affinity of the PICK1 PDZ domain for its binding partners we developed a purification scheme for PICK1 and a novel quantitative binding assay based on fluorescence...... polarization. Our results showed that the PICK1 PDZ domain binds the type II sequence presented by the human dopamine transporter (-WLKV) with an almost 15-fold and >100-fold higher affinity than the type I sequences presented by protein kinase Calpha (-QSAV) and the beta(2)-adrenergic receptor (-DSLL...

  16. The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

    DEFF Research Database (Denmark)

    da Silva Pinheiro, Paulo César; Jansen, Anna M; de Wit, Heidi

    2014-01-01

    Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6......, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca(2+) sensitivity were unaffected. Vesicle-fusion events had a reduced frequency and released lower amounts of transmitter per vesicle (i.......e., reduced quantal size). This was paralleled by a reduction in the mean single-vesicle capacitance, estimated by averaging time-locked capacitance traces. EM confirmed that LDCVs were fewer and of markedly reduced size in the PICK1 KO, demonstrating that all phenotypes can be explained by reductions...

  17. The impact of COI-based storage on order-picking times

    Directory of Open Access Journals (Sweden)

    Grzegorz Tarczyński

    2017-09-01

    Full Text Available Background: The increasing competitiveness on the global markets enforces the need for a fast and reliable delivery. This task is possible to perform by improving the order-picking systems. The implementation of automated storage and retrieval systems (AS/RS is not always profitable. In the warehouses where the order-picking is performed in accordance with the principle of picker-to-part rule, the picking efficiency optimization includes among others: the warehouse layout, the storage policy, the routing heuristic, the way of zoning, the order-batching method, and the sequencing of pick-lists. In the paper the impact of the storage policy on the order-picking times is checked. Methods: The influence of storage based on Heskett’s cube-per-order index (COI on the average order-picking times is analyzed. The items based on increasing values of COI index are divided on classes. To determine the demand for items the analytical function proposed by Caron is used. Results: In the paper the benefits of storage based on COI index are compared with random storage and storage based only on picking frequency. It is assumed that the bin, to which the picker collects items has limited capacity – some orders has to be divided on smaller pick-lists. The analysis was performed using simulation tools. Additionally, the algorithm (taking into account different sizes of picker’s bin for order-batching is presented. Conclusions: The analysis shows that the COI-based storage is particularly effective when the size of items increases. The COI-based curve is less skewed than the curve based only on picking frequency. The choice of storage policy should be carried out together with routing heuristic. The use of batching algorithm significantly increases the effectiveness of the order-picking process, but the optimal size of picker’s bin (and batch should be optimized with consideration the sorting process.

  18. Open Source Telecommunication Companies

    Directory of Open Access Journals (Sweden)

    Peter Liu

    2007-08-01

    Full Text Available Little is known about companies whose core business is selling telecommunications products that lever open source projects. Open source telecommunications (OST companies operate in markets that are very different from typical software product markets. The telecommunications market is regulated, vertically integrated, and proprietary designs and special chips are widely used. For a telecommunications product to be useful, it must interact with both access network products and core network products. Due to specifications in Service Agreements Levels, penalties for failures of telecommunications products are very high. This article shares information that is not widely known, including a list of OST companies and the open source projects on which they depend, the size and diversity of venture capital investment in OST companies, the nature of the commercial product-open source software and company-project relationships, ways in which OST companies make money, benefits and risks of OST companies, and competition between OST companies. Analysis of this information provides insights into the ways in which companies can build business models around open source software. These findings will be of interest to entrepreneurs, top management teams of incumbent companies that sell telecommunications products, and those who care about Ontario's ability to compete globally.

  19. Harnessing fluid-driven vesicles to pick up and drop off Janus particles.

    Science.gov (United States)

    Salib, Isaac; Yong, Xin; Crabb, Emily J; Moellers, Nicholas M; McFarlin, Gerald T; Kuksenok, Olga; Balazs, Anna C

    2013-02-26

    Using dissipative particle dynamics (DPD) simulations, we model the interaction between nanoscopic lipid vesicles and Janus nanoparticles in the presence of an imposed flow. Both the vesicle and Janus nanoparticles are localized on a hydrophilic substrate and immersed in a hydrophilic solution. The fluid-driven vesicle successfully picks up Janus particles on the substrate and transports these particles as cargo along the surface. The vesicle can carry up to four particles as its payload. Hence, the vesicles can act as nanoscopic "vacuum cleaners", collecting nanoscopic debris localized on the floors of the fluidic devices. Importantly, these studies reveal how an imposed flow can facilitate the incorporation of nanoparticles into nanoscale vesicles. With the introduction of a "sticky" domain on the substrate, the vesicles can also robustly drop off and deposit the particles on the surface. The controlled pickup and delivery of nanoparticles via lipid vesicles can play an important step in the bottom-up assembly of these nanoparticles within small-scale fluidic devices.

  20. The Danish East India Company

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2005-01-01

    The article analysis the first Danish East India Company incorporated in 1616, which was the first Danish Stock Company and which has impacts even on modern Danish company la......The article analysis the first Danish East India Company incorporated in 1616, which was the first Danish Stock Company and which has impacts even on modern Danish company la...

  1. Influence of the Hard-Faced Layer Welded on Tangential-Rotary Pick Operational Part on to Its Wear Rate

    Science.gov (United States)

    Krauze, Krzysztof; Skowronek, Tadeusz; Mucha, Kamil

    2016-12-01

    Problems related with abrasive wear of tangential-rotary picks during cutting process and its limitations, have been discussed in the present study. Essential for the parameters of cutting process geometrical, kinematic and material parameters of tangential-rotary picks and types of their wear, have been discussed. Testing procedure in aspect of the wear of tangential-rotary picks and their durability estimation, has been described. Manners of the abrasion of pick body and pick edge of the tangential-rotary picks, have been determined. Particular attention was paid to procedure of hard facing of the pick operational part and its influence onto mining process. Results of examination of tangential-rotary picks with hard facing layer on operational part near insert made of abrasion sintered carbide are also cited.

  2. 77 FR 40385 - Withdrawal of Regulatory Guide 7.3; Procedures for Picking Up and Receiving Packages of...

    Science.gov (United States)

    2012-07-09

    ... COMMISSION Withdrawal of Regulatory Guide 7.3; Procedures for Picking Up and Receiving Packages of... Commission) is withdrawing RG 7.3, ``Procedures for Picking Up and Receiving Packages of Radioactive Material... CFR) 20.205, ``Procedures for Picking Up, Receiving, and Opening Packages.'' Regulatory Guide...

  3. 76 FR 24856 - Heavy Forged Hand Tools (i.e., Axes & Adzes, Bars & Wedges, Hammers & Sledges, and Picks...

    Science.gov (United States)

    2011-05-03

    ..., and Picks & Mattocks) From the People's Republic of China: Final Results of the Expedited Sunset... & Adzes, Bars & Wedges, Hammers & Sledges, and Picks & Mattocks) from the People's Republic of China..., track tools and wedges; (3) picks and mattocks; and (4) axes, adzes and similar hewing tools. Hand...

  4. 76 FR 52313 - Heavy Forged Hand Tools (i.e., Axes & Adzes, Bars & Wedges, Hammers & Sledges, and Picks...

    Science.gov (United States)

    2011-08-22

    ..., and Picks & Mattocks) From the People's Republic of China: Continuation of Antidumping Duty Orders... & Adzes, Bars & Wedges, Hammers & Sledges, and Picks & Mattocks) (``Hand Tools'') from the People's... & Wedges, Hammers & Sledges, and Picks & Mattocks) From the People's Republic of China: Final Results...

  5. Niemann-Pick disease, type B with TRAP-positive storage cells and secondary sea blue histiocytosis

    Directory of Open Access Journals (Sweden)

    R. Saxena

    2009-09-01

    Full Text Available We present 2 cases of Niemann Pick disease, type B with secondary sea-blue histiocytosis. Strikingly, in both cases the Pick cells were positive for tartrate resistant acid phosphatase, a finding hitherto described only in Gaucher cells. This report highlights the importance of this finding as a potential cytochemical diagnostic pitfall in the diagnosis of Niemann Pick disease.

  6. Structure-modification and oil pick-up ability of PHBV as oil sorbent materials

    Institute of Scientific and Technical Information of China (English)

    Xuwen He; Dayi Qian; Bing Wu; Tong Wang

    2003-01-01

    The PHBV (β-hydroxybutyrate-co-β-hydroxyvalerate) foams as oil sorbent materials, which were prepared by salting out method based on PHBV and chloroform additive and their oil pick-up abilities were investigated. And the oil pick-up abilities of different PHBV foams as oil sorbent materials were compared. The results show that with the amount of chloroform additive and sodium chloride increasing, the oil pick-up rates, the oil-keeping rates and the second oil pick-up rates of PHBV foams can increase to different extent. When the amount of sodium chloride was 92%, the ratio of PHBV to chloroform was 1 (g): 14 (mL), the oil pick-up ability of the PHBV foam was optimal. And their oil pick-up ratios can reach 25.51 (26℃) and 27.51 g/g (17℃) in raw oil, which were 4-5 times more than those of PHBV powder. In addition, the structure-modified PHBV as oil sorbent materials also has some advantages, such as three-dimension structure, bio-degradability and good oil pick-up ability, so this kind of green oil sorbent materials will have great perspective in the future.

  7. Pengembangan Bumper Depan Mobil Pick Up Multiguna Pedesaan

    Directory of Open Access Journals (Sweden)

    Alfie Adiananda

    2015-03-01

    Full Text Available Tim Pengembangan Mobil Jurusan Teknik Mesin ITS bekerja sama dengan PT. INKA, PT. Railindo Global Karya, dan PT. Karya Tugas Anda melakukan pengembangan mobil GEA. Salah satu pengembangan yang akan dilakukan adalah pengembangan desain bumper depan. Dari hasil pengkajian pada bagian bumper, tidak ditemukan adanya fog lamp untuk membantu penerangan pada saat cuaca buruk. Rancangan bumper baru terbuat dari komposit jenis e-glass dan pengujiannya mengikuti standar, dimana gaya yang terjadi pada saat terjadi benturan dihitung berdasarkan standar pengujian ECE Regulation No.42. Oleh karena itu perlu dilakukan analisa kekuatan bumper depan dalam menahan benturan. Langkah-langkah dalam pengembangan bumper adalah mensimulasikan pengujian tumbukan untuk mengetahui nilai deformasi dan tegangan dari tiap ketebalan bumper yang berbeda, lalu setelah didapatkan ketebalan yang sesuai akan dilakukan proses pembuatan dan pemasangan bumper depan pada mobil pick up multiguna. Hasil yang didapatkan dari penelitan ini adalah bumper hasil pengembangan memiliki dimensi panjang 1430 mm, lebar 500 mm, tinggi 500 mm dan ketebalan bumper yang dipilih adalah 4 mm dimana tegangan yang terjadi adalah sebesar 785,98 MPa sedangkan deformasi bumper hasil simulasi adalah sebesar 18,160 mm, jauh lebih kecil daripada deformasi yang diizinkan yaitu 60 mm. Proses pembuatan bumper dengan metode wet-lay up.

  8. Single neutron pick-up on {sup 104}Pd

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, M.R.D.; Andre, J.P.A.M. de; Borello-Lewin, T.; Horodynski-Matsushigue, L.B.; Duarte, J.L.M.; Rodrigues, C.L. [Universidade de Sao Paulo, SP (Brazil). Inst. de Fisica; Ukita, G.M. [Universidade de Santo Amaro, SP (Brazil). Faculdade de Psicologia

    2006-12-15

    Low-lying levels of {sup 103}Pd have been investigated through the (d,t) reaction on {sup 104}Pd, at an incident deuteron energy of 15.0 MeV. Outgoing particles were momentum analyzed by an Enge magnetic spectrograph and detected in nuclear emulsion plates, with an energy resolution of 8 keV. Previous (d,t) work suffered from a much worse resolution than that here achieved. A partial analysis of the data obtained is reported, referring to six out of the fourteen scattering angles for which data were obtained. Angular distributions associated with eight of the thirteen levels seen up to 1.1 MeV of excitation have been compared to DWBA one-neutron pick-up predictions. Both, the attributed excitation energy values and the transferred angular momenta are in excellent agreement with the results of other kind of experiments, as tabulated by the Nuclear Data Sheets. Some peculiar structure characteristics, associated with the yrast 5/2{sup +}, 3/2{sup +} and 7/2{sup +} states found in the Ru chain could be recognized also in {sup 103}Pd, pointing to the possibility of a more global understanding of this transitional mass region. (author)

  9. Anesthesia Management in a Patient with Niemann Pick Disease

    Directory of Open Access Journals (Sweden)

    Zeynep Akoğul

    2013-04-01

    Full Text Available Niemann-Pick disease (NPD is an autosomal recessive, lipid storage disorder caused by the deficiency of the lysosomal enzyme sphingomyelinase or defective cholesterol transport from lysosome to cytosol. The clinical symptoms and signs include dysphagia, loss of motor function, hepatosplenomegaly, recurred respiratory infections, seizure, mental retardation, spasticity, myoclonic jerks and ataxia, but vary depending on the type of this disease. According to the observed pathology, patients require specialized therapy. Due to the high prevalence of the pathology in this group of patients, surgical interventions requiring general anaesthesia are common. Anesthetists have some difficulties with this group of patients. One of them is difficult ventilation because of hepatosplenomegaly and the other is difficult intubation. The metabolism of some of the anesthetic agents may be affected due to chronic use of anticonvulsant agents. Liver enzymes are elevated and platelet counts are reduced. Here we report an anesthesia management, difficulties and post-op follow up in a female child having NPD. Anesthetists have some difficulties in ventilation and intubation with NPD patients. In this situation ventilation should be with low tidal volume and high frequency. Because anesthetic agents might cause liver damage, they should be used cautiously. As a result, with keeping mind all these pathologies, anesthesia management to these patients should be used cautiously. (Journal of Current Pediatrics 2013; 11: 42-4

  10. Experiment on Conical Pick Cutting Rock Material Assisted with Front and Rear Water Jet

    Directory of Open Access Journals (Sweden)

    Xiaohui Liu

    2015-01-01

    Full Text Available Conical picks are one kind of cutting tools widely used in engineering machinery. In the process of rock breaking, the conical pick bears great cutting force and wear. To solve the problem, a new method, conical pick assisted with high pressure water jet, could break rock effectively, and four different configuration modes of water jet were presented. In this paper, based on the analysis of the different water jet configuration’s advantages and disadvantages, experiments on front water jet, new typed rear water jet, and the combination of those two water jet configuration modes were conducted to study the assisting cutting performance and obtain the quantitative results.

  11. The Other Itch That Rashes: a Clinical and Therapeutic Approach to Pruritus and Skin Picking Disorders.

    Science.gov (United States)

    Craig-Müller, Sören A; Reichenberg, Jason S

    2015-06-01

    Patients with skin picking disorders (SPDs) have historically been an under recognized and under treated group. Originally classified an impulse control disorder, skin picking disorder is now considered under the obsessive-compulsive disorder (OCD) and obsessive-compulsive-related disorder (OCRD) spectrum. Workup of SPD concentrates on differentiating this condition from primary skin disorders, systemic conditions associated with pruritus, and psychocutaneous syndromes. It is important to first address any underlying pruritic disorders (if present) that may be a trigger to pick the skin. First-line treatment for SPD is cognitive behavioral therapy. When necessary, pharmacologic therapy can be helpful as well.

  12. Cherry picking in ESRD: an ethical challenge in the era of pay for performance.

    Science.gov (United States)

    Parker, J Clint

    2011-01-01

    In poorly designed pay-for-performance schemes in which case mix adjustments are not adequate, self-interest could lead nephrologists toward cherry picking dialysis patients. Cherry picking, however, is morally problematic. First, it may manifest itself as a subtle form of covert rationing which threatens to undermine patient trust. Second, it involves shifting the burden of caring for sicker (and less financially attractive) patients to other nephrologists and dialysis units that do not practice cherry picking, creating injustices in the health care system. Finally, it treats patients as mere means through which nephrologists achieve reimbursement instead of as persons possessing dignity and deserving of respect.

  13. Conclusion: The balanced company

    DEFF Research Database (Denmark)

    2013-01-01

    This concluding chapter brings together the various research findings of the book "The balanced company - organizing for the 21st Century" and develops a general overview of their implications for our understanding of the balancing processes unfolding in companies and organizations....

  14. Virtual Company and Modelbank

    DEFF Research Database (Denmark)

    Thorsteinsson, Uffe

    1996-01-01

    Ansøgning til Socrates programmet vedr. Tematisk netværk inden for området Virtual Company and Modelbank......Ansøgning til Socrates programmet vedr. Tematisk netværk inden for området Virtual Company and Modelbank...

  15. Allocation for manufacturing companies

    Directory of Open Access Journals (Sweden)

    2010-06-01

    Full Text Available Assuring a high material availability for production is while reducing sourcing costs remains a major logistical challenge for producing companies. Lean economic processes, flexibility and responsiveness - beneficial both for the customer and for the supplier - are characteristics of an excellent customer-supplier relationship. Standard sourcing models offer a field-tested approach for setting up across company boarders processes.

  16. The mortality of companies

    Science.gov (United States)

    Daepp, Madeleine I. G.; Hamilton, Marcus J.; West, Geoffrey B.; Bettencourt, Luís M. A.

    2015-01-01

    The firm is a fundamental economic unit of contemporary human societies. Studies on the general quantitative and statistical character of firms have produced mixed results regarding their lifespans and mortality. We examine a comprehensive database of more than 25 000 publicly traded North American companies, from 1950 to 2009, to derive the statistics of firm lifespans. Based on detailed survival analysis, we show that the mortality of publicly traded companies manifests an approximately constant hazard rate over long periods of observation. This regularity indicates that mortality rates are independent of a company's age. We show that the typical half-life of a publicly traded company is about a decade, regardless of business sector. Our results shed new light on the dynamics of births and deaths of publicly traded companies and identify some of the necessary ingredients of a general theory of firms. PMID:25833247

  17. Locating single-point sources from arrival times containing large picking errors (LPEs): the virtual field optimization method (VFOM).

    Science.gov (United States)

    Li, Xi-Bing; Wang, Ze-Wei; Dong, Long-Jun

    2016-01-12

    Microseismic monitoring systems using local location techniques tend to be timely, automatic and stable. One basic requirement of these systems is the automatic picking of arrival times. However, arrival times generated by automated techniques always contain large picking errors (LPEs), which may make the location solution unreliable and cause the integrated system to be unstable. To overcome the LPE issue, we propose the virtual field optimization method (VFOM) for locating single-point sources. In contrast to existing approaches, the VFOM optimizes a continuous and virtually established objective function to search the space for the common intersection of the hyperboloids, which is determined by sensor pairs other than the least residual between the model-calculated and measured arrivals. The results of numerical examples and in-site blasts show that the VFOM can obtain more precise and stable solutions than traditional methods when the input data contain LPEs. Furthermore, we discuss the impact of LPEs on objective functions to determine the LPE-tolerant mechanism, velocity sensitivity and stopping criteria of the VFOM. The proposed method is also capable of locating acoustic sources using passive techniques such as passive sonar detection and acoustic emission.

  18. Increased emotional reactivity to affective pictures in patients with skin-picking disorder: Evidence from functional magnetic resonance imaging.

    Science.gov (United States)

    Wabnegger, Albert; Übel, Sonja; Suchar, Gerald; Schienle, Anne

    2017-09-01

    The predominant symptom of skin-picking disorder (SPD) is the recurrent picking of one's own skin, leading to tissue damage and discomfort. Psychological disorder models suggest an enhanced emotional reactivity in patients with SPD, which contributes to the maintenance of symptoms. This functional magnetic resonance imaging (fMRI) experiment analyzed both subjective and neuronal responses to affective pictures (categories: fear, disgust, happiness, neutral) in 19 women with SPD and 16 healthy controls. Also, affective traits (disgust, anxiety, depression) were assessed. Those with SPD scored higher on trait anxiety/depression, and reported higher intensities of negative emotions experienced during the picture viewing. On the neuronal level, the clinical group showed enhanced localized brain activation to fear, disgust and happiness in the amygdala, the insula and the orbitofrontal cortex. These regions are part of a brain circuit mediating affective responses and affective awareness. The current fMRI study provides first data on the neuronal basis of elevated emotional reactivity to affective pictures in SPD. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. On the Stability of Pick-up Ion Ring Distributions in the Outer Heliosheath

    Science.gov (United States)

    Summerlin, Errol J.; Viñas, Adolfo F.; Moore, Thomas E.; Christian, Eric R.; Cooper, John F.

    2014-10-01

    The "secondary energetic neutral atom (ENA)" hypothesis for the ribbon feature observed by the Interstellar Boundary Explorer (IBEX) posits that the neutral component of the solar wind continues beyond the heliopause and charge exchanges with interstellar ions in the Outer Heliosheath (OHS). This creates pick-up ions that gyrate about the draped interstellar magnetic field (ISMF) lines at pitch angles near 90° on the locus where the ISMF lies tangential to the heliopause and perpendicular to the heliocentric radial direction. This location closely coincides with the location of the ribbon feature according to the prevailing inferences of the ISMF orientation and draping. The locally gyrating ions undergo additional charge exchange and escape as free-flying neutral atoms, many of which travel back toward the inner solar system and are imaged by IBEX as a ribbon tracing out the locus described above. For this mechanism to succeed, the pick-up ions must diffuse in pitch angle slowly enough to permit secondary charge exchange before their pitch angle distribution substantially broadens away from 90°. Previous work using linear Vlasov dispersion analysis of parallel propagating waves has suggested that the ring distribution in the OHS is highly unstable, which, if true, would make the secondary ENA hypothesis incapable of rendering the observed ribbon. In this paper, we extend this earlier work to more realistic ring distribution functions. We find that, at the low densities necessary to produce the observed IBEX ribbon via the secondary ENA hypothesis, growth rates are highly sensitive to the temperature of the beam and that even very modest temperatures of the ring beam corresponding to beam widths of <1° are sufficient to damp the self-generated waves associated with the ring beam. Thus, at least from the perspective of linear Vlasov dispersion analysis of parallel propagating waves, there is no reason to expect that the ring distributions necessary to produce the

  20. On the stability of pick-up ion ring distributions in the outer heliosheath

    Energy Technology Data Exchange (ETDEWEB)

    Summerlin, Errol J.; Viñas, Adolfo F.; Moore, Thomas E.; Christian, Eric R.; Cooper, John F., E-mail: errol.summerlin@nasa.gov, E-mail: adolfo.figueroa-vinas-1@nasa.gov, E-mail: thomas.e.moore@nasa.gov, E-mail: eric.r.christian@nasa.gov, E-mail: john.f.cooper@nasa.gov [Heliophysics Science Division, NASAs Goddard Space Flight Center, 8800 Greenbelt Road, Greenbelt, MD (United States)

    2014-10-01

    The 'secondary energetic neutral atom (ENA)' hypothesis for the ribbon feature observed by the Interstellar Boundary Explorer (IBEX) posits that the neutral component of the solar wind continues beyond the heliopause and charge exchanges with interstellar ions in the Outer Heliosheath (OHS). This creates pick-up ions that gyrate about the draped interstellar magnetic field (ISMF) lines at pitch angles near 90° on the locus where the ISMF lies tangential to the heliopause and perpendicular to the heliocentric radial direction. This location closely coincides with the location of the ribbon feature according to the prevailing inferences of the ISMF orientation and draping. The locally gyrating ions undergo additional charge exchange and escape as free-flying neutral atoms, many of which travel back toward the inner solar system and are imaged by IBEX as a ribbon tracing out the locus described above. For this mechanism to succeed, the pick-up ions must diffuse in pitch angle slowly enough to permit secondary charge exchange before their pitch angle distribution substantially broadens away from 90°. Previous work using linear Vlasov dispersion analysis of parallel propagating waves has suggested that the ring distribution in the OHS is highly unstable, which, if true, would make the secondary ENA hypothesis incapable of rendering the observed ribbon. In this paper, we extend this earlier work to more realistic ring distribution functions. We find that, at the low densities necessary to produce the observed IBEX ribbon via the secondary ENA hypothesis, growth rates are highly sensitive to the temperature of the beam and that even very modest temperatures of the ring beam corresponding to beam widths of <1° are sufficient to damp the self-generated waves associated with the ring beam. Thus, at least from the perspective of linear Vlasov dispersion analysis of parallel propagating waves, there is no reason to expect that the ring distributions necessary to

  1. Laparoscopic ovum pick-up in spotted paca ( Cuniculus pacas

    Directory of Open Access Journals (Sweden)

    F.F.P.C. Barros

    2016-08-01

    Full Text Available ABSTRACT The aim of this work is study the laparoscopic ovum pick-up (LapOPU technique in spotted paca, describing surgery details, complications and oocyte recovery rate. Nine healthy adult non-pregnant captive females were used, in a total of 39 procedures. When the surgical plane of anaesthesia was achieved, the females were positioned at 20º Trendelenburg. Three 6mm trocars were placed on right and left inguinal and hypogastric regions. Abdomen was inflated with CO2 and the intra-abdominal pressure was stablished in 10mmHg. Follicular punctures were performed moving the ovaries with atraumatic forceps. For punctures, an 18-gauge 3.5 inch long needle attached to a vacuum system with pressure not exceeding 65mmHg was used. Oocytes were recovered into 50mL centrifuge tubes with media composed of PBS supplemented with 10 IU/mL of heparin and kept at 36°C. R Software was used for statistical analysis. Data normality distribution (Shapiro test and variances homoscedasticity (Bartlett test were tested and descriptive statistics (mean±SD was used to present the results. It was only possible to perform LapOPU in 30 of 39 laparoscopies (76.92%. The surgical total time was 37.34 ± 18.53 minutes. The total number of visualized follicles, aspirated follicles, and retrieved oocytes were 502, 415, and 155, respectively. And the same parameters per animal were: 14.34 ± 12.23, 11.86 ± 10.03, and 4.43 ± 4.69 respectively. Oocyte recovery rate was 32.56 ± 27.32%. In conclusion, caudal positioning of portals with slight triangulation allows good viewing of the abdominal cavity and eases the manipulation of the ovaries. Thus this described LapOPU technique is feasible in spotted paca and easy to perform.

  2. TOTAL REWARDS MODEL IN ROMANIAN COMPANIES

    Directory of Open Access Journals (Sweden)

    Elena-Sabina HODOR

    2014-04-01

    Full Text Available Total Rewards Management is a subject of major importance for companies, because, by using models for this, firms can achieve their objectives of high performance. In order to analyse a validated total rewards model in Romanian Accounting and Consulting Companies, it is used The WorldatWork Total Rewards Model, which depict what contributes to applicant attraction and employee motivation and retention. Thus, the methodology of the previous survey is adjusted to the local context. The conclusions for the methodological aspects illustrate that the present research involves three strategic steps in order to achieve the objectives presented: the analysis of organizational environment of the companies from the sample, checking if Total Rewards Model proposed in the previous research is applicable for the same romanian companies from the previous survey, the analysing of the differences between results, and, if necessary, the adaptation of the model for Romania.

  3. TOTAL REWARDS MODEL IN ROMANIAN COMPANIES

    Directory of Open Access Journals (Sweden)

    Elena-Sabina HODOR

    2014-04-01

    Full Text Available Total Rewards Management is a subject of major importance for companies, because, by using models for this, firms can achieve their objectives of high performance. In order to analyse a validated total rewards model in Romanian Accounting and Consulting Companies, it is used The WorldatWork Total Rewards Model, which depict what contributes to applicant attraction and employee motivation and retention. Thus, the methodology of the previous survey is adjusted to the local context. The conclusions for the methodological aspects illustrate that the present research involves three strategic steps in order to achieve the objectives presented: the analysis of organizational environment of the companies from the sample, checking if Total Rewards Model proposed in the previous research is applicable for the same romanian companies from the previous survey, the analysing of the differences between results, and, if necessary, the adaptation of the model for Romania.

  4. 从2006年高考题看pick up的用法

    Institute of Scientific and Technical Information of China (English)

    万春霞

    2007-01-01

    <正>请看2006年高考英语福建卷第28题:She____Japanese when she was in Japan.Now she can speak it freely. A.picked out B.made out C.made up D.picked up解析:答案是D。此题考查的是短语动词pick up的用法。在本题中的意思是"偶然获得,无意中学会……"。Pick up是中学英语中常用的短语动词,也是高考近几年经常考

  5. PAL-XFEL cavity beam position monitor pick-up design and beam test

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sojeong, E-mail: sojung8681@postech.ac.kr; Park, Young Jung; Kim, Changbum; Kim, Seung Hwan; Shin, Dong Cheol; Han, Jang-Hui; Ko, In Soo

    2016-08-11

    As an X-ray Free Electron Laser, PAL-XFEL is about to start beam commissioning. X-band cavity beam position monitor (BPM) is used in the PAL-XFEL undulator beam line. Prototypes of cavity BPM pick-up were designed and fabricated to test the RF characteristics. Also, the beam test of a cavity BPM pick-up was done in the Injector Test Facility (ITF). In the beam test, the raw signal properties of the cavity BPM pick-up were measured at a 200 pC bunch charge. According to the RF test and beam test results, the prototype cavity BPM pick-up design was confirmed to meet the requirements of the PAL-XFEL cavity BPM system.

  6. Pick-up Lines”: A Fun Way to Facilitate Learning Microbiological Concepts

    Directory of Open Access Journals (Sweden)

    Thomas Edison E. dela Cruz

    2014-05-01

    Full Text Available Learning microbiology can be made fun by writing funny lines related to microbiology. Students were tasked to create their own pick-up lines and explain these based on their understanding of the basic concepts in microbiology.

  7. Using Robot Skills for Flexible Reprogramming of Pick Operations in Industrial Scenarios

    DEFF Research Database (Denmark)

    Andersen, Rasmus S.; Nalpantidis, Lazaros; Krüger, Volker

    2014-01-01

    objects on tabletops and pick them up in a user-specified manner. The programming itself is primarily done through kinesthetic teaching. We show that the skill has robustness towards the location and shape of the object to pick, and that objects from a real industrial production line can be handled. Also......Traditional robots used in manufacturing are very efficient for solving specific tasks that are repeated many times. The robots are, however, difficult to (re-)configure and (re-)program. This can often only be done by expert robotic programmers, computer vision experts, etc., and it requires...... additionally lots of time. In this paper we present and use a skill based framework for robotic programming. In this framework, we develop a flexible pick skill, that can easily be reprogrammed to solve new specific tasks, even by non-experts. Using the pick skill, a robot can detect rotational symmetric...

  8. COMPRESSIBLE VIRTUAL WINDOW ALGORITHM IN PICKING PROCESS CONTROL OF AUTOMATED SORTING SYSTEM

    Institute of Scientific and Technical Information of China (English)

    WU Yaohua; ZHANG Yigong; WU Yingying

    2008-01-01

    Compared to fixed virtual window algorithm (FVWA), the dynamic virtual window algorithm (DVWA) determines the length of each virtual container according to the sizes of goods of each order, which saves space of virtual containers and improves the picking efficiency. However, the interval of consecutive goods caused by dispensers on conveyor can not be eliminated by DVWA, which limits a further improvement of picking efficiency. In order to solve this problem, a compressible virtual window algorithm (CVWA) is presented. It not only inherits the merit of DVWA but also compresses the length of virtual containers without congestion of order accumulation by advancing the beginning time of order picking and reasonably coordinating the pace of order accumulation. The simulation result proves that the picking efficiency of automated sorting system is greatly improved by CVWA.

  9. Travel motives of participants in the Cape Argus Pick n Pay Cycle Tour

    African Journals Online (AJOL)

    South African Journal for Research in Sport, Physical Education and Recreation. Journal Home ... The Cape Argus Pick n Pay Cycle Tour is the largest cycling events in South Africa. The event ... South Africa; Marketing; Factor analysis.

  10. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    DEFF Research Database (Denmark)

    Holst, Birgitte; Madsen, Kenneth L; Jansen, Anna M;

    2013-01-01

    Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here...... was rescued in flies by reintroducing PICK1 in neurosecretory cells producing somatotropic peptides. PICK1-deficient mice were characterized by decreased body weight and length, increased fat accumulation, impaired GH secretion, and decreased storage of GH in the pituitary. Decreased GH storage was supported...... dependent expression. Finally, both in a Drosophila model of type 2 diabetes and in high-fat-diet-induced obese mice, we observed up-regulation of PICK1 mRNA expression. Our findings suggest that PICK1, together with ICA69, is critical during budding of immature secretory vesicles from the TGN and thus...

  11. Using the Min/Max Method for Replenishment of Picking Locations

    Directory of Open Access Journals (Sweden)

    Apsalons Raitis

    2017-03-01

    Full Text Available The irregularity of removing quantities from a definite picking location in a warehouse very often results in the stock out in the particular picking address. In practice, the Red Card principle is used to determine a critical level for each picking location when it is necessary to start the replenishment of stock in the picking address. The question is how to calculate an adequate critical level. The guidelines in this paper explain in detail the solution of the problem using the Min/Max stock control method and mathematical algorithms adjusted by authors. In order to check the validity of these mathematical algorithms of the Min/Max method, the simulation modelling has been also done and presented.

  12. Tabu Search Heuristics for the Order Batching Problem in Manual Order Picking Systems

    OpenAIRE

    Sebastian Henn; Gerhard Wäscher

    2010-01-01

    In manual order picking systems, order pickers walk or ride through a distribution warehouse in order to collect items requested by (internal or external) customers. In order to perform these operations efficiently, it is usually required that customer orders are combined into (more substantial) picking orders of limited size. The Order Batching Problem considered in this paper deals with the question of how a given set of customer orders should be combined such that the total length of all t...

  13. Algorithms for On-line Order Batching in an Order-Picking Warehouse

    OpenAIRE

    Sebastian Henn

    2009-01-01

    In manual order picking systems, order pickers walk or ride through a distribution warehouse in order to collect items required by (internal or external) customers. Order batching consists of combining these – indivisible – customer orders into picking orders. With respect to order batching, two problem types can be distinguished: In off-line (static) batching all customer orders are known in advance. In on-line (dynamic) batching customer orders become available dynamically over time. This r...

  14. Going Global: Key Insights from Two Mexican Companies

    Directory of Open Access Journals (Sweden)

    Martha RIVERA

    2015-12-01

    Full Text Available This paper explores how Mexican companies in different industries have achieved international expansion, while at the same time preserving local elements in executing their strategies. For this initial stage of research, the analysis focuses on two companies: a Grupo Bimbo, the number one company in the bakery industry worldwide and b KidZania, one of the world’s top indoor family entertainment centers. The research methodology is based on in-depth interviews with CEOs and key executives from the two companies done over a period of more than ten years. We have also used secondary data such as press releases and case studies. By contrasting their strategies and comparing them with those of other multinationals like Ford Motor Company and Santander Bank, we identified major issues that we condensed into 10 key insights. Understanding how these companies have struggled and succeeded in gaining international markets can help other companies tailor their own strategies. Our argument is that the typical simplified international expansion process is insufficient when companies need to compete in the global arena. Becoming an MNC implies handling an entire ecosystem: building local presence, establishing joint ventures or alliances with local companies, recruiting local talent, developing new business models, reshaping the value proposition, developing new brands or introducing traditional ones with a local flavor, and understanding the supply chain and routes to market. Therefore, a number of aspects have to be taken into consideration beyond just simply selecting a market. For certain companies in emerging markets, making the decision to grow internationally was not initially in their strategic vision, but economic liberalization in their home country and the threat of being purchased by an MNC from a developed country triggered the decision. There is a learning process in international expansion, and trial and error is common and useful. The

  15. SICHUAN GEOPHYSICAL COMPANY

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Sichuan Geophysical Company (abbreviated as SCGC below), originally named Sichuan Geophysical Company of CNPC Sichuan Petroleum, was founded in 1956 and is a subsidiary of CNPC Chuanqing Drilling Engineering Company Limited. With more than 50 years' development, SCGC now owns almost 3800 employees and has become a big oil & gas seismic exploration engineering service enterprise with the characteristic mountain seismic exploration techniques, and its annual business turnover reaches nearly 2 billion RMB. It can provide the integrated seismic exploration engineering service including seismic data acquisition, processing, interpretation, and geological comprehensive evaluation in various complex regions for clients at home and abroad.

  16. Valuation of Companies

    Directory of Open Access Journals (Sweden)

    J. Lisník

    2007-01-01

    Full Text Available This paper deals with valuating telecommunications companies. Six groups operating mainly in the European countries are compared. The comparison is based on financial and techno-economic indicators.These indicators are used to value the company by the DCF method. However, many companies have only a very short history. To value these, classical methods like DCF or real options are not suitable. In this case, methods based on market confrontation seem to be efficient. A further exploration of these methods is also the topic of my graduate studies 

  17. 精密草莓采摘机器人优化设计—基于光程调节结构%Optimization Design of Precision Strawberry-picking Robot—Based on Optical Path Adjustment Structure

    Institute of Scientific and Technical Information of China (English)

    刘志刚; 王风燕; 魏纯

    2016-01-01

    In the process of strawberry picking robots , because strawberry fruit is fragile , and its volume is small , so the breakage and leakage rate is high , which are related to strawberry picking robot positioning accuracy .In order to improve the positioning accuracy of strawberry picking process , in the acquisition robot localization system introduced a new kind of optical positioning results , and puts forward the vacuum for a white Cell optical path adjustment structure , using the feedback of the signal , realizes the optimization design of picking mechanism .In order to verify the reliability of the de-sign precision of strawberry picking robots , the design of the robot strawberry picking experiment , and the breakage and leakage rate were tested , by testing found that the device can effectively reduce the breakage and leakage of strawberry picking up rate , and lower picking time , high efficiency and can meet the needs of the strawberry picking the practical production .%在机器人草莓采摘过程中 ,由于草莓果实比较脆弱,加上其体积较小,因此存在较高的破碎率和漏采率,这都与草莓采摘机器人的定位精度有关. 为了提高草莓采摘过程的定位精度,在采集机器人定位系统的引入了一种新的光定位结果,并提出了一种用于真空怀特池光程调节的机构,利用该机构的反馈源信号,实现了对采摘机构的优化设计. 为了验证设计的精密草莓采摘机器人的可靠性,设计了机器人的草莓采摘试验,并对其破碎率和漏采率进行了测试. 通过测试发现:该装置可以有效地降低草莓采摘的破碎率和漏拾率,且采摘耗时低、效率高,可以满足草莓采摘实际生产的需要.

  18. Emotion regulation in pathological skin picking: findings from a non-treatment seeking sample.

    Science.gov (United States)

    Snorrason, Ivar; Smári, Jakob; Olafsson, Ragnar P

    2010-09-01

    Pathological skin picking (PSP) is characterized by excessive picking of the skin, resulting in significant distress or functional impairment. The aim of the present study was to investigate the emotion regulation hypothesis of PSP. University students with PSP (n = 55) and without history of PSP (n = 55) were asked to retrospectively rate the intensity of affective states before, during, and after skin picking episodes. The results showed that for a majority of the PSP sufferers, intensity of certain negative affective states (i.e. anxiety, tension or boredom) was pronounced just before picking, and diminished significantly in the period from before to after picking. Relief and gratification increased during picking whereas guilt increased afterwards. A similar pattern emerged in the control group, although a much lower level of intensity was reported. Participants were also asked to fill out questionnaires concerning emotion regulation difficulties, emotion reactivity, depression, anxiety and worry. Hierarchical logistic regressions demonstrated that emotion regulation difficulties as well as emotion reactivity predicted PSP diagnosis after depression, anxiety and worry were controlled for. Furthermore, emotion regulation difficulties statistically mediated the relationship between emotion reactivity and PSP. Overall, the findings support an emotion regulation model of PSP.

  19. PICKY: a novel SVD-based NMR spectra peak picking method.

    Science.gov (United States)

    Alipanahi, Babak; Gao, Xin; Karakoc, Emre; Donaldson, Logan; Li, Ming

    2009-06-15

    Picking peaks from experimental NMR spectra is a key unsolved problem for automated NMR protein structure determination. Such a process is a prerequisite for resonance assignment, nuclear overhauser enhancement (NOE) distance restraint assignment, and structure calculation tasks. Manual or semi-automatic peak picking, which is currently the prominent way used in NMR labs, is tedious, time consuming and costly. We introduce new ideas, including noise-level estimation, component forming and sub-division, singular value decomposition (SVD)-based peak picking and peak pruning and refinement. PICKY is developed as an automated peak picking method. Different from the previous research on peak picking, we provide a systematic study of the proposed method. PICKY is tested on 32 real 2D and 3D spectra of eight target proteins, and achieves an average of 88% recall and 74% precision. PICKY is efficient. It takes PICKY on average 15.7 s to process an NMR spectrum. More important than these numbers, PICKY actually works in practice. We feed peak lists generated by PICKY to IPASS for resonance assignment, feed IPASS assignment to SPARTA for fragments generation, and feed SPARTA fragments to FALCON for structure calculation. This results in high-resolution structures of several proteins, for example, TM1112, at 1.25 A. PICKY is available upon request. The peak lists of PICKY can be easily loaded by SPARKY to enable a better interactive strategy for rapid peak picking.

  20. 78 FR 11638 - Michigan Consolidated Gas Company, DTE Gas Company, DTE Gas Company; Notice of Petition

    Science.gov (United States)

    2013-02-19

    ... Energy Regulatory Commission Michigan Consolidated Gas Company, DTE Gas Company, DTE Gas Company; Notice... Docket Nos. PR13-29-000, and PR13-30-000 (not consolidated), Michigan Consolidated Gas Company (MichCon) and DTE Gas Company (DTE Gas) filed to institute a name change to both itself from MichCon to DTE...

  1. 75 FR 13524 - Northern Natural Gas Company, Southern Natural Gas Company, Florida Gas Transmission Company, LLC...

    Science.gov (United States)

    2010-03-22

    ... Energy Regulatory Commission Northern Natural Gas Company, Southern Natural Gas Company, Florida Gas... of Application March 16, 2010. Take notice that on March 5, 2010, Northern Natural Gas Company... other owners, Southern Natural Gas Company, Florida Gas Transmission Company, LLC, Transcontinental...

  2. CNPC Picks out Key Techniques for Development in 2002

    Institute of Scientific and Technical Information of China (English)

    Shi Wei

    2002-01-01

    @@ CNPC will focus on a number of key technologies relating to the company's development and economic performance in 2002, including 12 technical projects at the State level and other 59 projects identified by CNPC itself. The oil giant will concentrate the efforts on the exploration and development technologies, such as "preliminary exploration study and target evaluation in major oil and gas exploration fields," "systematic techniques for improvement of water flooding and tertiary oil recovery at later high water-cut period" and "systematic techniques for heat recovery of heavy crude."

  3. 地方高校图书馆向当地企业开展文献信息服务的可行性探讨%A Study on the Feasibility of the Information Service to the Local Companies from Local Colleges

    Institute of Scientific and Technical Information of China (English)

    李歌维

    2011-01-01

    地方中小企业因观念、资金、技术、人才等局限,信息利用水平很低,与地方高校图书馆合作是地方企业既节约又高效获取信息服务的好途径.共建共享、信息整合、牵线搭桥、远程服务、专业导航、“镜象”服务、个性化服务等方式是地方高校图书馆向当地中小企业提供信息服务的主要途径和方法.图书馆主动与地方企业交流合作,是充分发挥信息搜集、加工、处理和传递功能,繁荣当地社会文化,服务当地经济建设,推动高校与地方经济协调发展,促进地方高校图书馆自身快速成长的明智选择.%The related information usage is very much limited in the small enterprises because of their ideas, fund, technology and talents. It is an economic and highly efficient way to get information service if they cooperate with local colleges. The major information service ways in the local colleges are co-construction and sharing, information integration, information serving as a bridge, remote service, information specialty navigation, image service, and individualized information service. It is a wise choice for the college libraries if they actively cooperate with the companies to fully functioning their information searching, processing and information transfer, which will help the local social culture and economy development, improve the coordinated development of the colleges and local economy and fasten the college library development.

  4. PICK1 confers anti-inflammatory effects in acute liver injury via suppressing M1 macrophage polarization.

    Science.gov (United States)

    Xie, Juan; Wu, Xiaoqin; Zhou, Qun; Yang, Yang; Tian, Yuanyao; Huang, Cheng; Meng, Xiaoming; Li, Jun

    2016-08-01

    Protein interacting with C kinase 1 (PICK1) is a scaffolding protein mainly implicated in neurological diseases, however, the function of PICK1 in acute liver injury (ALI) remains unknown. Our study found a dramatical decrease in mRNA and protein levels of PICK1 in liver tissues and isolated Kupffer cells (KCs) from the liver in mice with ALI. Furthermore, pretreatment the mice with ALI with FSC-231, a pharmacological inhibitor of PICK1, could significantly augment inflammatory response. Furthermore, in vitro studies showed that both lipopolysaccharide (LPS) and interferon gamma (IFN-γ) significantly reduced the expression of PICK1, while IL-4 elevated its expression in RAW 264.7 cells. Additionally, over-expression of PICK1 inhibited the expression of M1 biomarkers by suppressing NF-κB activity, and enhanced the expression of M2 biomarkers by promoting STAT6 activity. In contrast, knockdown of PICK1 or FSC-231 pretreatment promoted M1 polarization and suppressed M2 polarization. Besides, caveolin-1 was identified as a potential target gene controlled by PICK1 in RAW 264.7 cells. Mechanistic investigation revealed a dual role of PICK1 in regulating macrophage polarization and implied PICK1 as a potential therapeutic target in ALI.

  5. Estimating order-picking times for return heuristic - equations and simulations

    Directory of Open Access Journals (Sweden)

    Grzegorz Tarczyński

    2015-09-01

    Full Text Available Background: A key element of the evaluation of warehouse operation is the average order-picking time. In warehouses where the order-picking process is carried out according to the "picker-to-part" rule the order-picking time is usually proportional to the distance covered by the picker while picking items. This distance can by estimated by simulations or using mathematical equations. In the paper only the best described in the literature one-block rectangular warehouses are considered. Material and methods: For the one-block rectangular warehouses there are well known five routing heuristics. In the paper the author considers the return heuristic in two variants. The paper presents well known Hall's and De Koster's equations for the average distance traveled by the picker while completing items from one pick list. The author presents own proposals for calculating the expected distance. Results: the results calculated by the use of mathematical equations (the formulas of Hall, De Koster and own propositions were compared with the average values obtained using computer simulations. For the most cases the average error does not exceed 1% (except for Hall's equations. To carry out simulation the computer software Warehouse Real-Time Simulator was used. Conclusions: the order-picking time is a function of many variables and its optimization is not easy. It can be done in two stages: firstly using mathematical equations the set of the potentially best variants is established, next the results are verified using simulations. The results calculated by the use of equations are not precise, but possible to achieve immediately. The simulations are more time-consuming, but allow to analyze the order-picking process more accurately.

  6. Pre-Interaction Management in Multinational Companies in Central Europe

    Science.gov (United States)

    Nekvapil, Jiri; Sherman, Tamah

    2009-01-01

    This article is devoted to the linguistic, communicative and sociocultural situation in branches of multinational companies located in the Czech Republic and Hungary. There are typically several languages used in these branches. In addition to the local languages, there are the languages of the parent companies--most commonly English or German,…

  7. Korean Investment in EU through Holding Companies: A Case Study

    Directory of Open Access Journals (Sweden)

    Seong-Bong Lee

    1998-09-01

    Full Text Available When transnational enterprises set subsidiary companies in certain area, their major aim is to invest indirectly through the holding companies which hold invested share. Especially, because of the geographical neighborhood and economic integration, investing by holding companies is common in Europe. In Europe, taking full advantage of holding company is out of the following two reasons. Firstly, the efficiency and flexibility of the manage strategy of a group could be elevated by making full use of the holding company. Secondly, the transnational enterprises have the possibility of flexible management at the tax strategy level. Recently, the Korean companies are making the best use of holding companies when they are Marching into the EU. In the year 1996, group K purchased 8 enterprises of a certain industry section of B, a German company, setting holding companies in Germany. The analysis result of the case shows that the manage efficiency could be risen and the taxation could be reduced by way of making use of holding companies. As to the Korean investment efficiency of overseas indirect investment in EU, this thesis brought forward a blueprint about integrating the local companies.

  8. Oil Companies Climb Global List

    Institute of Scientific and Technical Information of China (English)

    JESSY ZHANG

    2006-01-01

    @@ Backed by the huge market size,China's energy companies have been ranked in the group of the world's largest industry players. On September 6th,eight companies from the Chinese mainland and six companies from Hong Kong SAR were included in this year's Platts Top 250 Energy Companies List.

  9. Refinement of arrival-time picks using a cross-correlation based workflow

    Science.gov (United States)

    Akram, Jubran; Eaton, David W.

    2016-12-01

    We propose a new iterative workflow based on cross-correlation for improved arrival-time picking on microseismic data. In this workflow, signal-to-noise ratio (S/N) and polarity weighted stacking are used to minimize the effect of S/N and polarity fluctuations on the pilot waveform computation. We use an exhaustive search technique for polarity estimation through stack power maximization. We use pseudo-synthetic and real microseismic data from western Canada in order to demonstrate the effectiveness of proposed workflow relative to Akaike information criterion (AIC) and a previously published cross-correlation based method. The pseudo-synthetic microseismic waveforms are obtained by introducing Gaussian noise and polarity fluctuations into waveforms from a high S/N microseismic event. We find that the cross-correlation based approaches yield more accurate arrival-time picks as compared to AIC for low S/N waveforms. AIC is not affected by waveform polarities as it works on individual receiver levels whereas the accuracy of existing cross-correlation method decreases in spite of using envelope correlation. We show that our proposed workflow yields better and consistent arrival-time picks regardless of waveform amplitude and polarity variations within the receiver array. After refinement, the initial arrival-time picks are located closer to the best estimated manual picks.

  10. The use of technologies for the process of picking: implications and propositions

    Directory of Open Access Journals (Sweden)

    Jorge Arnaldo Troche Escobar

    2015-02-01

    Full Text Available In the present, businesses are facing numerous challenges with regard to their competitiveness in a global and complex marketplace, being required an ongoing review and evaluation of their management processes. The process of picking in Warehouses is one of the most critical, both for its complexity either by its high cost, so high levels of efficiency are necessary and desirable. The objective of this paper is to present the results of a research about the technologies on picking process in warehouses. They were developed a conceptual model and a methodology to support the choice of technological solutions for picker-to-part’s strategy. The proposed approach incorporates the various dimensions of decision process for assessment and selection of picking technologies based both, in the literature review, as from empirical contributions obtained from a provider of order picking technologies. In the decision process highlights the highly complexity, as it involves several levels of decision and several dimensions that pass through the layout of the warehouse, the methodology of picking, the level of traceability wanted, the coding model of products, among others determinant factors, beyond the cost of the technological solution itself.

  11. The Impact of Visual Guided Order Picking on Ocular Comfort, Ocular Surface and Tear Function.

    Directory of Open Access Journals (Sweden)

    Angelika Klein-Theyer

    Full Text Available We investigated the effects of a visual picking system on ocular comfort, the ocular surface and tear function compared to those of a voice guided picking solution.Prospective, observational, cohort study.Institutional.A total of 25 young asymptomatic volunteers performed commissioning over 10 hours on two consecutive days.The operators were guided in the picking process by two different picking solutions, either visually or by voice while their subjective symptoms and ocular surface and tear function parameters were recorded.The visual analogue scale (VAS values, according to subjective dry eye symptoms, in the visual condition were significantly higher at the end of the commissioning than the baseline measurements. In the voice condition, the VAS values remained stable during the commissioning. The tear break-up time (BUT values declined significantly in the visual condition (pre-task: 16.6 sec and post-task: 9.6 sec in the right eyes, that were exposed to the displays, the left eyes in the visual condition showed only a minor decline, whereas the BUT values in the voice condition remained constant (right eyes or even increased (left eyes over the time. No significant differences in the tear meniscus height values before and after the commissioning were observed in either condition.In our study, the use of visually guided picking solutions was correlated with post-task subjective symptoms and tear film instability.

  12. Captive insurance companies.

    Science.gov (United States)

    Strauss, Peter

    2014-01-01

    The landscape of the business world is changing; and now, more than ever, business owners are recognizing that life is filled with risks: known risk, calculated risk, and unexpected risk. Every day, businesses thrive or fail based on understanding the risk of owning and operating their business, and business owners are recognizing that there are alternative risk financing mechanisms other than simply taking out a basket of standard coverage as recommended by your friendly neighborhood agent. A captive insurance company is an insurance company established to provide a broad range of risk management capabilities to affiliated companies. The captive is owned by the business owner and can provide insurance to the business for potential future losses, whether or not the losses are already covered by a commercial carrier or are "self-insured." The premiums paid by your business are tax deductible. Meanwhile, the premiums that your captive collects are tax-free up to $1.2 million annually.

  13. Companies as "Cyborgs"?

    DEFF Research Database (Denmark)

    Thompson, Grahame

    This paper investigates the legal and commercial consequences of companies being considered as both an entity and a person in law – hence the notion of ‘cyborg’ in its title. It concentrates upon legal personhood and relates this particular feature to the issue of corporate citizenship. In turn...... corporate citizenship provides a link to considering the political role of companies, since in claiming citizenship they are implicitly at least claiming a particular set of political rights consequent upon that status, and announcing a particular politically constrained context associated...... with their operational characteristics. But what would be involved in granting companies full citizenship rights in the image of natural person citizenship? The paper explores this issue in connection to the differences between corporate social responsibility and an earlier idea of the socially responsible corporation...

  14. Complement is dispensable for neurodegeneration in Niemann-Pick disease type C

    Directory of Open Access Journals (Sweden)

    Lopez Manuel E

    2012-09-01

    Full Text Available Abstract Background The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency impeded the elimination of apoptotic neurons, allowing survival. In the genetic lysosomal storage disease Niemann-Pick C (NPC, caused by loss of NPC1 function, the expression of complement system components, C1q especially, is elevated in degenerating brain regions of Npc1-/- mice. Here we test whether complement is mediating neurodegeneration in NPC disease. Findings In normal mature mice, C1q mRNA was found in neurons, particularly cerebellar Purkinje neurons (PNs. In Npc1-/- mice, C1q mRNA was additionally found in activated microglia, which accumulate during disease progression and PN loss. Interestingly, C1q was not enriched on or near degenerating neurons. Instead, C1q was concentrated in other brain regions, where it partially co-localized with a potential C1q inhibitor, chondroitin sulfate proteoglycan (CSPG. Genetic deletion of C1q, or of the downstream complement pathway component C3, did not significantly alter patterned neuron loss or disease progression. Deletion of other immune response factors, a Toll-like receptor, a matrix metalloprotease, or the apoptosis facilitator BIM, also failed to alter neuron loss. Conclusion We conclude that complement is not involved in the death and clearance of neurons in NPC disease. This study supports a view of neuroinflammation as a secondary response with non-causal relationship to neuron injury in the disease. This disease model may prove useful for understanding the conditions in which complement and immunity do contribute to neurodegeneration in other disorders.

  15. RESTRUCTURING COMPANIES UNDER CRISIS

    Directory of Open Access Journals (Sweden)

    Hezi Aviram SHAYB

    2016-12-01

    Full Text Available Nobody is planning to fail, but many companies are failing because of lack of planning. Real business experience showed during the years that crisis can be prevented, avoided or limited. If detected in time, the risks associated with the crisis can be mitigated and the effects can be diminished, with the condition that the actions required are done fast, in a sharp and accurate manner. When it comes, a crisis brings an intense level of pressure and under these conditions there is no time or room for mistakes. Delays, losing focus and lack of planning will bring a company one step away from failure. The right way to deal with crisis, if required measures are not done in time, is to minimize the losses and reposition in the best way possible. Analysing the success stories of some of the biggest and strongest companies in the world, led to an important conclusion: the majority of these companies were in the situation to face huge crises which threatened their ability to survive in certain moments, on their way to success. With the right planning and by setting a proper organisational structure, the negative aspects of the crisis can be turned into benefits and opportunities for the company. The most critical challenge for management is to assess the level of exposure to risk of the company and identify the key points to focus on in order to overcome the crisis and create value. In order to set up a strong plan in dealing with crisis, a business organisation needs reliable, efficient and effective tools and this is what this article is all about.

  16. RESTRUCTURING COMPANIES UNDER CRISIS

    Directory of Open Access Journals (Sweden)

    Hezi Aviram SHAYB

    2016-12-01

    Full Text Available Nobody is planning to fail, but many companies are failing because of lack of planning. Real business experience showed during the years that crisis can be prevented, avoided or limited. If detected in time, the risks associated with the crisis can be mitigated and the effects can be diminished, with the condition that the actions required are done fast, in a sharp and accurate manner. When it comes, a crisis brings an intense level of pressure and under these conditions there is no time or room for mistakes. Delays, losing focus and lack of planning will bring a company one step away from failure. The right way to deal with crisis, if required measures are not done in time, is to minimize the losses and reposition in the best way possible. Analysing the success stories of some of the biggest and strongest companies in the world, led to an important conclusion: the majority of these companies were in the situation to face huge crises which threatened their ability to survive in certain moments, on their way to success. With the right planning and by setting a proper organisational structure, the negative aspects of the crisis can be turned into benefits and opportunities for the company. The most critical challenge for management is to assess the level of exposure to risk of the company and identify the key points to focus on in order to overcome the crisis and create value. In order to set up a strong plan in dealing with crisis, a business organisation needs reliable, efficient and effective tools and this is what this article is all about.

  17. Lubricant Film Breakdown and Material Pick-Up in Sheet Forming of Advanced High Strength Steels and Stainless Steels when Using Environmental Friendly Lubricants

    DEFF Research Database (Denmark)

    Ceron, Ermanno; Olsson, M.; Bay, Niels

    2014-01-01

    Increasing focus on environmental issues in industrial production has urged sheet metal stamping companies to look for new tribo-systems in order to substitute hazardous lubricants such as chlorinated paraffin oils. The efficiency of chlorinated paraffin is due to the fact that the lubricant reacts...... chemically with the tool and workpiece material forming thin films, which adhere strongly to the surfaces and reduce the tendency to metal-metal contact and material pick-up. Production tests of new, environmentally benign tribo-systems are, however, costly and laboratory tests are preferred as a preliminary...... and stainless steels. The performance of the tribo-systems was analyzed in the laboratory by means of a newly developed simulative test as well as in an industrial production process. The results obtained show a good agreement between the laboratory test and the industrial production process regarding...

  18. PREVENTION OF COMPANY RISKS

    Directory of Open Access Journals (Sweden)

    SUCI U GHEORGHE

    2014-10-01

    Full Text Available A company’s manager has to create and maintain a healthy internal control system. An efficient internal control system implies the implementation in the company of risk management. Each company, but also each individual, who tries to attain certain objectives, establishes the activities which lead to the achievement of goals and, at the same time, tries to identify as many “threats” as possible, in order to take the necessary measures to eliminate them. Thus, even if one is not familiar with the concepts of risk and risk management, one acts, consciously or not, for that purpose.

  19. Competitor Analysis : Company X

    OpenAIRE

    Valkama, Suvi

    2014-01-01

    The purpose of the thesis was to create a competitor analysis of the market of stainless steel swimming pools for the commissioner Company X, a company that will be set up in the near future. The thesis aimed at finding out the commissioner’s assets in producing stainless steel swimming pools as well as defining its competitive advantage. This was done by identifying the relative strengths and weaknesses of the main competitors named by the commissioner. Moreover, the purpose of the thesis wa...

  20. COMPANY ACTIVITY FINANCIAL RISK

    Directory of Open Access Journals (Sweden)

    Caruntu Genu Alexandru

    2012-12-01

    Full Text Available In economic and financial activity, risk is an inherent financial decisions, encountered in daily agenda of managers of companies. Unexpected changes in the price of a product development not only affect the financial results of a company, but can cause even bankruptcy. In fact, the nature of financial decisions involve uncertainty. Financial decisions are made based on cash flows under future contracts, which are par excellence incerte.Activitatea an enterprise that holds any weight in the industry is subject to risks, since it can not predict with certainty different components of its outcome (cost, quantity, price and operating cycle (purchase, processing, sales.

  1. Identifying P phase arrival of weak events: The Akaike Information Criterion picking application based on the Empirical Mode Decomposition

    Science.gov (United States)

    Li, Xibing; Shang, Xueyi; Morales-Esteban, A.; Wang, Zewei

    2017-03-01

    Seismic P phase arrival picking of weak events is a difficult problem in seismology. The algorithm proposed in this research is based on Empirical Mode Decomposition (EMD) and on the Akaike Information Criterion (AIC) picker. It has been called the EMD-AIC picker. The EMD is a self-adaptive signal decomposition method that not only improves Signal to Noise Ratio (SNR) but also retains P phase arrival information. Then, P phase arrival picking has been determined by applying the AIC picker to the selected main Intrinsic Mode Functions (IMFs). The performance of the EMD-AIC picker has been evaluated on the basis of 1938 micro-seismic signals from the Yongshaba mine (China). The P phases identified by this algorithm have been compared with manual pickings. The evaluation results confirm that the EMD-AIC pickings are highly accurate for the majority of the micro-seismograms. Moreover, the pickings are independent of the kind of noise. Finally, the results obtained by this algorithm have been compared to the wavelet based Discrete Wavelet Transform (DWT)-AIC pickings. This comparison has demonstrated that the EMD-AIC picking method has a better picking accuracy than the DWT-AIC picking method, thus showing this method's reliability and potential.

  2. P wave onset time picking with the B-spline biorthogonal wavelet

    Institute of Scientific and Technical Information of China (English)

    TENG Yun-tian; WANG Xi-zhen; WANG Xiao-mei; MA Jie-mei; XU Jian-hua

    2006-01-01

    @@ The seismic wave consists of many seismic phases, which contain rich geophysical information from the hypocenter, medium of seismic wave passing through and so on. It is very important to detect and pick these seismic phases for understanding the mechanism of earthquake, the Earth structure and property of seismic waves. In order to reduce or avoid the loss resulted from the earthquake, one of the important goals of seismic event detecting is to obtain its related information before and after it occurs. Because of the particularity of P wave and S wave,the seismic event detecting focuses on distinguishing P and S waves and picking their onset time, it has been becoming one of the research hotspots for many geophysicists to pick the P and S wave arrival accurately and effectively.

  3. Classic Pick's disease type with ubiquitin-positive and tau-negative inclusions: case report

    Directory of Open Access Journals (Sweden)

    Brito-Marques Paulo Roberto de

    2001-01-01

    Full Text Available We report on a patient presenting Pick's disease similar to the one reported by Pick in 1892, with ubiquitin-positive and tau-negative inclusions. His diagnosis was made on the basis of clinical (language disturbance and behavioural disorders, neuropsychological (progressive aphasia of the expression type and late mutism, neuroimaging with magnetic resonance (bilateral frontal and temporal lobes atrophy and brain single photon emission computed tomography (frontal and temporal lobes hypoperfusion studies. Macroscopic examination showed atrophy on the frontal and temporal lobes. The left hippocampus displayed a major circumscribed atrophy. The diagnostic confirmation was made by the neuropathological findings of the autopsy that showed neuronal loss with gliosis of the adjacent white matter and apearence of status spongiosus in the middle frontal and especially in the upper temporal lobes. There were also neuronal swelling (ballooned cell and argyrophilic inclusions (Pick's bodies in the left and right hippocampi. Anti-ubiquitin reaction tested positive and anti-tau tested negative.

  4. Robotic vision system for random bin picking with dual-arm robots

    Directory of Open Access Journals (Sweden)

    Kang Sangseung

    2016-01-01

    Full Text Available Random bin picking is one of the most challenging industrial robotics applications available. It constitutes a complicated interaction between the vision system, robot, and control system. For a packaging operation requiring a pick-and-place task, the robot system utilized should be able to perform certain functions for recognizing the applicable target object from randomized objects in a bin. In this paper, we introduce a robotic vision system for bin picking using industrial dual-arm robots. The proposed system recognizes the best object from randomized target candidates based on stereo vision, and estimates the position and orientation of the object. It then sends the result to the robot control system. The system was developed for use in the packaging process of cell phone accessories using dual-arm robots.

  5. Brushes and picks used on nails during the surgical scrub to reduce bacteria: a randomised trial.

    Science.gov (United States)

    Tanner, J; Khan, D; Walsh, S; Chernova, J; Lamont, S; Laurent, T

    2009-03-01

    Though brushes are no longer used on the hands and forearms during the surgical scrub, they are still widely used on the nails. The aim of this study was to determine whether nail picks and nail brushes are effective in providing additional decontamination during a surgical hand scrub. A total of 164 operating department staff were randomised to undertake one of the following three surgical hand-scrub protocols: chlorhexidine only; chlorhexidine and a nail pick; or chlorhexidine and a nail brush. Bacterial hand sampling was conducted before and 1h after scrubbing using a modified version of the glove juice method. No statistically significant differences in bacterial numbers were found between any two of the three intervention groups. Nail brushes and nail picks used during surgical hand scrubs do not decrease bacterial numbers and are unnecessary.

  6. The Kharbarelli Pick-Up: How & Why This Throwing Technique Works

    Directory of Open Access Journals (Sweden)

    Steve Scott

    2012-07-01

    Full Text Available The throwing technique that came to be known as the Kharbarelli Pick-up in the world of competitive judo is a good example of how different cultures and their unique grappling traditions have changed the look of this Olympic sport. This presentation of the Kharbarelli Pick-up illustrates and explains the theory, mechanics, and application of this unorthodox, effective and crowd-pleasing throwing technique. The author has an extensive background in sambo and judo and studied this technique for a number of years after seeing it used in international judo and sambo events. The Kharbarelli Pick-up, while considered “unorthodox” and not Japanese in origin, is effective because it exhibits the common elements of using an opponent’s balance and movement in the same way a “traditional” judo throw does.

  7. Lytle S. Adams, DDS (1883-1970): Nonstop Airmail Pick-up inventor.

    Science.gov (United States)

    Christen, Arden G; Christen, Joan A

    2005-11-01

    Between 1923 and 1940, a restless, optimistic, self-styled, inventor, Lytle S. Adams, DDS (1883-1970) was tirelessly working to develop a nonstop, airmail delivery and pick-up system. He believed that his invention would enable air postal services to serve those smaller, more isolated communities that would otherwise be bypassed due to economic and operational reasons. For 17 years, Adams vigorously promoted his pick-up system in both public and private arenas, and he even obtained congressional support for his ideas. However, he was unable to arrange for long-term, hardheaded financial and engineering support. Consequently, the once promising Adams Nonstop Airmail Pick-up System had only temporary and limited success. His endeavor, like others which came before and after, initially appeared to be a sound idea in search of inspired realization.

  8. PICK1在中枢神经系统疾病中的作用%PICK1 is associated with central nervous system diseases

    Institute of Scientific and Technical Information of China (English)

    卢宇婷; 朱丽君

    2009-01-01

    PICK1(protein interacting with C kinase 1)是一种含PDZ(PSD-95/Dlg/ZO1)结构域和BAR (Bin/amphiphysin/Rvs)结构域的蛋白,它可通过PDZ结构域与多种蛋白发生相互作用,其中一些蛋白与中枢神经系统(CNS)疾病密切相关.文中综述了近年来关于PICK1在几种中枢神经系统疾病中的作用研究,以期对疾病研究和临床治疗提供参考.

  9. Transnational companies and production global networks

    Directory of Open Access Journals (Sweden)

    Valentina Golea

    2010-12-01

    Full Text Available Internationalizing a company is an objective process. The historical reality shows that, while developing, the company tends to exceed its local, national and regional limits of business environment, in order to expand its activity into the global economic space, whose formatting is possible through the very company’s movement towards exterior. This process is based on the imminent expansionism of the market forces, their tendencies to invade the environment “unmarketedly”, and to include it in an economic system based on the market mechanism. Companies involve themselves in the international production because they have a specific competitive advantage which is best exploited in this way. The advantage can consist in a product or in a brevetted technique, but it may also include management techniques or such as: company’s or its employee’s qualification and expertise.

  10. Revisiting the theory of the evolution of pick-up ion distributions: magnetic or adiabatic cooling?

    Directory of Open Access Journals (Sweden)

    H. J. Fahr

    2008-01-01

    Full Text Available We study the phasespace behaviour of heliospheric pick-up ions after the time of their injection as newly created ions into the solar wind bulk flow from either charge exchange or photoionization of interplanetary neutral atoms. As interaction with the ambient MHD wave fields we allow for rapid pitch angle diffusion, but for the beginning of this paper we shall neglect the effect of quasilinear or nonlinear energy diffusion (Fermi-2 acceleration induced by counterflowing ambient waves. In the up-to-now literature connected with the convection of pick-up ions by the solar wind only adiabatic cooling of these ions is considered which in the solar wind frame takes care of filling the gap between the injection energy and energies of the thermal bulk of solar wind ions. Here we reinvestigate the basics of the theory behind this assumption of adiabatic pick-up ion reactions and correlated predictions derived from it. We then compare it with the new assumption of a pure magnetic cooling of pick-up ions simply resulting from their being convected in an interplanetary magnetic field which decreases in magnitude with increase of solar distance. We compare the results for pick-up ion distribution functions derived along both ways and can point out essential differences of observational and diagnostic relevance. Furthermore we then include stochastic acceleration processes by wave-particle interactions. As we can show, magnetic cooling in conjunction with diffusive acceleration by wave-particle interaction allows for an unbroken power law with the unique power index γ=−5 beginning from lowest velocities up to highest energy particles of about 100 KeV which just marginally can be in resonance with magnetoacoustic turbulences. Consequences for the resulting pick-up ion pressures are also analysed.

  11. Haloperidol augmentation of fluvoxamine in skin picking disorder: a case report

    Directory of Open Access Journals (Sweden)

    Luca Maria

    2012-07-01

    Full Text Available Abstract Introduction Compulsive skin picking, being part of the broader category of impulse control disorders, is considered a residual diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. It is characterized by excessive scratching or picking of normal skin, or skin with minor surface irregularities, and occurs in 2% of patients attending dermatology clinics. Despite the clinical relevance of this disorder, no clear guidelines are available yet; clinical management is, therefore, compromised and the day-to-day clinical practice is burdened by difficulties. Studies on selective serotonin reuptake inhibitors and anti-epileptic drugs have provided limited results. The association between anti-depressants and anti-epileptics has been found to be beneficial in some impulse control disorders, but in skin picking no previous studies have been conducted on this pharmacological approach. There are very few reports on the efficacy of anti-psychotics in skin picking. Case presentation The therapeutic path described in this case report produced good results for a 59-year-old Caucasian woman. The first therapeutic approach, with fluvoxamine and oxcarbazepine was partially effective; then, the suspension of oxcarbazepine and haloperidol augmentation of fluvoxamine were adopted. After 10 weeks, a significant improvement of the disease was observed: the clinical picture and the associated symptoms were nearly solved. Conclusions To the best of our knowledge, this is the first article reporting the association of fluvoxamine and haloperidol in skin picking disorder. It might be useful to perform further research regarding the treatment of skin picking disorder: in clinical practice, several variables might limit the choice of certain drugs. Therefore, it would be useful for the clinician to be aware of other therapeutic options.

  12. Smart customers, dumb companies.

    Science.gov (United States)

    Locke, C

    2000-01-01

    Customers today are being bombarded with an overwhelming array of choices. To alleviate customer frustration, say Steven Cristol and Peter Sealey in Simplicity Marketing, companies should stop creating new brands and product extensions. Better to consolidate product and service functions by following a four R approach: replace, repackage, reposition, and replenish. That's an outmoded, dictatorial view of markets, says Christopher Locke. Far from being stymied by choices, customers are rapidly becoming smarter than the companies that pretend to serve them. In this networked economy, people are talking among themselves, and that changes everything. Locke predicts we'll see a growing number of well-defined micromarkets--groups of customers converging in real time around entertaining and knowledgeable voices--such as NPR's car guys and the Motley Fool investment site. "Micromedia" Web sites will replace traditional advertising because they'll provide credible user-supplied news about products and services. Locke contends that an open exchange of information solves the "problem" of choice much better than manipulative strategies like simplicity or even permission marketing. Companies can participate in micromarkets through what Locke dubs "gonzo marketing." If Ford, for example, discovers that a subset of its employees are organic gardeners, it may offer support to a big independent organic-gardening Web site with donations and employee volunteers. This marketing effort would be driven not by advertising managers but by people with genuine interest in each micromarket, so it would have credibility with customers. With gonzo marketing, both companies and their markets will benefit.

  13. Pork in good company?

    DEFF Research Database (Denmark)

    Verbeke, Wim; Perez-Cueto, Federico J.; de Barcellos, Marcia D.

    2013-01-01

    (odds ratio=1.30) as side dishes to pork meat. Substantial cross-cultural differences were revealed in line with typical pork consumption and meal composition habits in the respective countries. Finally, this study found that the company of family plays a significant role when choosing side dishes...

  14. A Robust Formant Extraction Algorithm Combining Spectral Peak Picking and Root Polishing

    Directory of Open Access Journals (Sweden)

    Seo Kwang-deok

    2006-01-01

    Full Text Available We propose a robust formant extraction algorithm that combines the spectral peak picking, formants location examining for peak merger checking, and the root extraction methods. The spectral peak picking method is employed to locate the formant candidates, and the root extraction is used for solving the peak merger problem. The location and the distance between the extracted formants are also utilized to efficiently find out suspected peak mergers. The proposed algorithm does not require much computation, and is shown to be superior to previous formant extraction algorithms through extensive tests using TIMIT speech database.

  15. Perfil Neuropsicológico de la Enfermedad de Niemann Pick Tipo C: Estudio de Caso

    OpenAIRE

    Molina, David Andres; Gómez, Mónica

    2016-01-01

    El síndrome de Niemann-Pick es una enfermedad caracterizada por falla en el metabolismo lipídico y su almacenamiento a nivel lisosomal, cuya causa esta relacionada con mutaciones específicas en los genes NPC1 y NPC2, los cuales producen acumulación de colesterol no esterificado y esfingolípidos en los lisosomas. El presente artículo expone un perfil  neuropsicológico de la Enfermedad de Niemann Pick Tipo C, padecida por un paciente  masculino de nueve años edad. Se realizo un estudio de caso ...

  16. IcePick: a flexible surface-based system for molecular diversity.

    Science.gov (United States)

    Mount, J; Ruppert, J; Welch, W; Jain, A N

    1999-01-14

    IcePick is a system for computationally selecting diverse sets of molecules. It computes the dissimilarity of the surface-accessible features of two molecules, taking into account conformational flexibility. Then, the intrinsic diversity of an entire set of molecules is calculated from a spanning tree over the pairwise dissimilarities. IcePick's dissimilarity measure is compared against traditional 2D topological approaches, and the spanning tree diversity measure is compared against commonly used variance techniques. The method has proven easy to implement and is fast enough to be used in selection of reactants for numerous production-sized combinatorial libraries.

  17. Design of Intelligent Monitoring and Path Planning in Picking Robot%采摘机器人智能监控和路径规划设计研究

    Institute of Scientific and Technical Information of China (English)

    吴芳; 汪小志

    2016-01-01

    In order to improve the picking robot autonomous navigation and automatic positioning capability and improve the accuracy of path planning for the machine vision, based on MSP430F149 of TI company,it designs a function auto-matic picking robot with the monitoring terminal and GPS navigation, the robot path planning in real-time processing, communication, location and alarm integration and automation control function.Through the test, the MSP430 F149 micro controller has the advantages of low power consumption, small size, simple operation, and easy to maintain the system management and maintenance.5 robot path planning for the overall running accuracy and path planning of mobile time u-tilization, path planning leakage recovery rate were tested, it was found by test that five kinds of path planning method for various index to test the effect best, combined with MSP430F149 MCU and PID algorithm, to realize picking robot, auto-matic picking function, which can improve the robot's picking accuracy and provides a valuable reference for the picking robot intelligent design.%为了提高采摘机器人自主导航和自动化定位能力,提升机器视觉的路径规划精度,基于 TI 公司的MSP430 F149 单片机,设计了一款具有监控终端和GPS导航功能的自动采摘机器人,实现了机器人路径规划实时处理、通讯、定位、报警一体化和自动化控制功能. 通过测试发现,MSP430F149 单片机具有功耗低、体积小、操作简单,便于系统管理维护等优点. 对机器人5 种路径规划的总体行驶精度路、径规划的移动时间利用率、路径规划的漏采率进行了测试,通过测试发现:5 种路径规划中套行法的各种指标测试效果最好. 同时,结合MSP430 F149 单片机和PID算法,实现了采摘机器人高效自动化采摘功能,提高了机器人的采摘精度,为采摘机器人的智能化设计提供了较有价值的参考 .

  18. Valuation of companies activity on sustainability level

    Directory of Open Access Journals (Sweden)

    S. Nadolski

    2007-03-01

    Full Text Available Purpose: Paper presents a possibilities of companies valuation due to their activity in accordance with sustainable development.Design/methodology/approach: The article describes best known methods of companies assessment (stock indices, non-financial reports and other indicators connected with sustainability. Also there is a history of indices methodology which comes from ethical, religious problems and sustainable development principles.Findings: There is still more companies interested in being (as a part of sustainability indices or other rankings. Research organizations should be concentrated on different type of rankings which contain summary report of best available techniques.Research limitations/implications: Every sustainability index or non-financial reports ranking should be important part of companies management thinking. It is important idea to create these indices for every local stock exchange. Also companies should publish true and clear non-financial reports.Originality/value: The paper concerns on existing indices and tries to make new look at sustainability problems. Important conclusions are connected with non-financial reports and possible connections between indices, rankings and best available techniques.

  19. The number of pickers and stock-keeping unit arrangement on a uni-directional picking line

    Directory of Open Access Journals (Sweden)

    Hagspihl, Robert

    2014-10-01

    Full Text Available The order picking process is often the single largest expense in a distribution centre (DC. The DC considered in this paper uses a picking line configuration to perform order picking. The number of pickers in a picking line, and the initial arrangement of stock-keeping units (SKUs, are two important factors that affect the total completion time of the picking lines. In this paper, the picking line configuration is simulated with an agent-based approach to describe the behaviour of an individual picker. The simulation is then used to analyse the effect of the number of pickers and the SKU arrangement. Verification and validation of this model shows that the model represents the real-world picking line to a satisfactory degree. Marginal analysis (MA was chosen to determine a ‘good’ number of pickers by means of the simulation model. A look-up table is presented to provide decision support for the choice of a ‘good’ number of pickers to improve completion times of the picking line, for the properties of a specific picking line. The initial SKU arrangement on a picking line is shown to be a factor that can affect the level of picker congestion and the total completion time. The greedy ranking and partitioning (GRP and organ pipe arrangement (OPA techniques from the literature, as well as the historical SKU arrangements used by the retailer under consideration, were compared with the proposed classroom discipline heuristic (CDH for SKU arrangement. It was found that the CDH provides an more even spread of SKUs that are picked most frequently, thus decreasing congestion and total completion time.

  20. Marketing company profile: Consumer-led company features

    Directory of Open Access Journals (Sweden)

    Kovačević Ivana

    2005-01-01

    Full Text Available Starting point in defining modern company profile is its absolute orientation to customers. So called Customer-led companies are those which all their activities put toward customers instead of product which is offered. These companies try to make all their sectors to be oriented toward customers.

  1. 77 FR 38085 - Importer of Controlled Substances; Notice of Registration; Stepan Company

    Science.gov (United States)

    2012-06-26

    ... physical security systems, verification of the company's compliance with state and local laws, and a review... Enforcement Administration Importer of Controlled Substances; Notice of Registration; Stepan Company By Notice dated May 11, 2012, and published in the Federal Register on May 21, 2012, 77 FR 30025, Stepan Company...

  2. 78 FR 64015 - Importer of Controlled Substances; Notice of Registration; Stepan Company

    Science.gov (United States)

    2013-10-25

    ... physical security systems, verification of the company's compliance with state and local laws, and a review... Enforcement Administration Importer of Controlled Substances; Notice of Registration; Stepan Company By Notice... Company, Natural Products Department, 100 W. Hunter Avenue, Maywood, New Jersey 07607, made application by...

  3. A Semiautomated Multilayer Picking Algorithm for Ice-sheet Radar Echograms Applied to Ground-Based Near-Surface Data

    Science.gov (United States)

    Onana, Vincent De Paul; Koenig, Lora Suzanne; Ruth, Julia; Studinger, Michael; Harbeck, Jeremy P.

    2014-01-01

    Snow accumulation over an ice sheet is the sole mass input, making it a primary measurement for understanding the past, present, and future mass balance. Near-surface frequency-modulated continuous-wave (FMCW) radars image isochronous firn layers recording accumulation histories. The Semiautomated Multilayer Picking Algorithm (SAMPA) was designed and developed to trace annual accumulation layers in polar firn from both airborne and ground-based radars. The SAMPA algorithm is based on the Radon transform (RT) computed by blocks and angular orientations over a radar echogram. For each echogram's block, the RT maps firn segmented-layer features into peaks, which are picked using amplitude and width threshold parameters of peaks. A backward RT is then computed for each corresponding block, mapping the peaks back into picked segmented-layers. The segmented layers are then connected and smoothed to achieve a final layer pick across the echogram. Once input parameters are trained, SAMPA operates autonomously and can process hundreds of kilometers of radar data picking more than 40 layers. SAMPA final pick results and layer numbering still require a cursory manual adjustment to correct noncontinuous picks, which are likely not annual, and to correct for inconsistency in layer numbering. Despite the manual effort to train and check SAMPA results, it is an efficient tool for picking multiple accumulation layers in polar firn, reducing time over manual digitizing efforts. The trackability of good detected layers is greater than 90%.

  4. 75 FR 22423 - Pick-Sloan Missouri Basin Program, Eastern and Western Division Proposed Project Use Power Rate

    Science.gov (United States)

    2010-04-28

    ... Bureau of Reclamation Pick-Sloan Missouri Basin Program, Eastern and Western Division Proposed Project... of the Pick-Sloan Missouri Basin Program, Eastern and Western Divisions, Proposed Project Use Power Rate Adjustment. ] SUMMARY: The Bureau of Reclamation is reopening the comment period for the...

  5. 41 CFR 102-41.230 - May SASPs pick up or store donated drug paraphernalia in their distribution centers?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May SASPs pick up or store donated drug paraphernalia in their distribution centers? 102-41.230 Section 102-41.230 Public... SASPs pick up or store donated drug paraphernalia in their distribution centers? No, you must...

  6. Nanorobotic Manipulation Setup for Pick-and-Place Handling and non-destructive Characterization of Carbon Nanotubes

    DEFF Research Database (Denmark)

    Eicchorn, V.; Carlson, Kenneth; Andersen, Karin Nordström

    2007-01-01

    . The pick-and-place task is carried out by using an electrothermal actuated microgripper, designed for controlled manipulation of nanotubes. The nanotube is picked up from an array of multiwalled carbon nanotubes (MWCNTs) and transferred to the tip of an atomic force microscope (AFM) probe in order...

  7. 75 FR 1408 - Pick-Sloan Missouri Basin Program, Eastern and Western Division Proposed Project Use Power Rate

    Science.gov (United States)

    2010-01-11

    ... Bureau of Reclamation Pick-Sloan Missouri Basin Program, Eastern and Western Division Proposed Project Use Power Rate AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of Proposed Pick-Sloan Missouri... Reclamation (Reclamation) is proposing a rate adjustment (proposed rate) for Project Use Power for the...

  8. Functional Assessment and Behavioral Treatment of Skin Picking in a Teenage Girl With Prader-Willi Syndrome

    NARCIS (Netherlands)

    Radstaake, M.; Didden, H.C.M.; Bolio, M.M.L.; Lang, R.; Lancioni, G.E.; Curfs, L.M.G

    2011-01-01

    Skin picking is common in individuals with Prader-Willi Syndrome (PWS) but few treatment studies exist. This study reports the successful functional behavioral assessment (FBA) and treatment of skin picking in a 16-year-old female with PWS. A treatment package based on FBA results consisted of diffe

  9. Continuous Access to Competing Stimulation as Intervention for Self-Injurious Skin Picking in a Child with Autism

    Science.gov (United States)

    Ladd, Mara V.; Luiselli, James K.; Baker, Lorianne

    2009-01-01

    Children with autism frequently display self-injurious behavior (SIB), but skin picking--a less severe topography of SIB--has not been the focus of much clinical research. The present study evaluated a home-based intervention that was implemented with a 9-year-old girl who had autism and picked her fingers with resulting tissue damage. The…

  10. The class characteristic mark of the H&M Mul-T-Lock picking tool in toolmarks examination.

    Science.gov (United States)

    Volkov, Nikolai; Finkelstein, Nir; Novoselsky, Yehuda; Tsach, Tsadok

    2014-07-01

    Mul-T-Lock is a high security lock cylinder distinguished by the use of a telescoping "pin-in-pin"-tumbler design. Picking the Mul-T-Lock cylinder with a traditional picking tool is highly complicated because it can get stuck between the inner and outer pins. The H&M Mul-T-Lock picking tool was designed to overcome this problem and facilitate the picking of the "pin-in-pin" cylinder. The purpose of this research is to determine whether H&M Mul-T-Lock picking tool leaves class characteristic mark and whether it can be distinguished from traditional picking tools marks and from regular key marks. It also describes and determines the class characteristic mark left on telescopic pins, its origin, recurrence, and its benefit to the toolmarks examiner. When receiving a Mul-T-Lock from a crime scene, a toolmarks examiner can quickly determine whether or not it was picked by an H&M Mul-T-Lock picking tool by noticing the class characteristic mark which this typical tool leaves.

  11. APASVO: A free software tool for automatic P-phase picking and event detection in seismic traces

    Science.gov (United States)

    Romero, José Emilio; Titos, Manuel; Bueno, Ángel; Álvarez, Isaac; García, Luz; Torre, Ángel de la; Benítez, M.a. Carmen

    2016-05-01

    The accurate estimation of the arrival time of seismic waves or picking is a problem of major interest in seismic research given its relevance in many seismological applications, such as earthquake source location and active seismic tomography. In the last decades, several automatic picking methods have been proposed with the ultimate goal of implementing picking algorithms whose results are comparable to those obtained by manual picking. In order to facilitate the use of these automated methods in the analysis of seismic traces, this paper presents a new free, open source, software graphical tool, named APASVO, which allows picking tasks in an easy and user-friendly way. The tool also provides event detection functionality, where a relatively imprecise estimation of the onset time is sufficient. The application implements the STA-LTA detection algorithm and the AMPA picking algorithm. An autoregressive AIC-based picking method can also be applied. Besides, this graphical tool is complemented with two additional command line tools, an event picking tool and a synthetic earthquake generator. APASVO is a multiplatform tool that works on Windows, Linux and OS X. The application can process data in a large variety of file formats. It is implemented in Python and relies on well-known scientific computing packages such as ObsPy, NumPy, SciPy and Matplotlib.

  12. Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1

    DEFF Research Database (Denmark)

    Søgaard, Rikke; Borre, Lars; Braunstein, Thomas H

    2013-01-01

    effect on trafficking of AMPA-type glutamate receptors. The 11 extreme C-terminal residues specific for the GLT1b variant are essential for its specific interaction with the PICK1 PDZ domain, but a functional consequence of this interaction has remained unresolved. To identify a functional effect of PICK...

  13. Building Company Loyalty System

    OpenAIRE

    Haniková, Alžběta

    2010-01-01

    The thesis discusses the importance of loyal customers, and loyalty system as a tool for building loyalty. It defines loyalty and customer satisfaction, it deals with the issue of customer retention. It describes the history and types of loyalty programs, important factors for deciding on their implementation and problems associated with them. The practical part is concerned with the clothing market, Orsay company and its Orsay Club loyalty systeme. The work also includes a survey of the loya...

  14. Building Company Loyalty System

    OpenAIRE

    Haniková, Alžběta

    2010-01-01

    The thesis discusses the importance of loyal customers, and loyalty system as a tool for building loyalty. It defines loyalty and customer satisfaction, it deals with the issue of customer retention. It describes the history and types of loyalty programs, important factors for deciding on their implementation and problems associated with them. The practical part is concerned with the clothing market, Orsay company and its Orsay Club loyalty systeme. The work also includes a survey of the loya...

  15. enjoy the company of

    Institute of Scientific and Technical Information of China (English)

    柳延延

    2004-01-01

    @@ 请先读一段文字: John is a clean-cut, great-looking guy who likes his father and mother, who frowns on drugs, who takes his profession seriously, who likes to have a good time, who enjoys the company of the opposite sex, and who has his own goals and values. He's a boy with no surprise up in his sleeve.

  16. Picking Teams: Motivational Effects of Team Selection Strategies in Physical Education

    Science.gov (United States)

    Barney, David; Prusak, Keven A.; Beddoes, Zack; Eggett, Dennis

    2016-01-01

    The tacitly sanctioned practice of publicly picking teams in physical education has been categorized as instructionally inappropriate, yet its practice persists. Therefore, the purpose of this two-study article was to examine its effects on achievement goals orientations and motivational profiles of male junior high school physical education…

  17. Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs.

    Science.gov (United States)

    Norousi, Ramin; Wickles, Stephan; Leidig, Christoph; Becker, Thomas; Schmid, Volker J; Beckmann, Roland; Tresch, Achim

    2013-05-01

    Cryo-electron microscopy (cryo-EM) studies using single particle reconstruction are extensively used to reveal structural information on macromolecular complexes. Aiming at the highest achievable resolution, state of the art electron microscopes automatically acquire thousands of high-quality micrographs. Particles are detected on and boxed out from each micrograph using fully- or semi-automated approaches. However, the obtained particles still require laborious manual post-picking classification, which is one major bottleneck for single particle analysis of large datasets. We introduce MAPPOS, a supervised post-picking strategy for the classification of boxed particle images, as additional strategy adding to the already efficient automated particle picking routines. MAPPOS employs machine learning techniques to train a robust classifier from a small number of characteristic image features. In order to accurately quantify the performance of MAPPOS we used simulated particle and non-particle images. In addition, we verified our method by applying it to an experimental cryo-EM dataset and comparing the results to the manual classification of the same dataset. Comparisons between MAPPOS and manual post-picking classification by several human experts demonstrated that merely a few hundred sample images are sufficient for MAPPOS to classify an entire dataset with a human-like performance. MAPPOS was shown to greatly accelerate the throughput of large datasets by reducing the manual workload by orders of magnitude while maintaining a reliable identification of non-particle images.

  18. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology

    DEFF Research Database (Denmark)

    Kirkegaard, Thomas; Roth, Anke G; Petersen, Nikolaj H T

    2010-01-01

    inhibition of ASM, effectively revert the Hsp70-mediated stabilization of lysosomes. Notably, the reduced ASM activity in cells from patients with Niemann-Pick disease (NPD) A and B-severe lysosomal storage disorders caused by mutations in the sphingomyelin phosphodiesterase 1 gene (SMPD1) encoding for ASM...

  19. Phenomenological Characteristics, Social Problems, and the Economic Impact Associated with Chronic Skin Picking

    Science.gov (United States)

    Flessner, Christopher A.; Woods, Douglas W.

    2006-01-01

    In this study, the authors collected data on the demographic characteristics, phenomenology, and social and economic impact of skin picking. A total of 92 participants completed an anonymous, Internet-based survey through a link to the Trichotillomania Learning Center's home page. Results indicated that skin pickers experienced social,…

  20. An automated framework for NMR resonance assignment through simultaneous slice picking and spin system forming.

    Science.gov (United States)

    Abbas, Ahmed; Guo, Xianrong; Jing, Bing-Yi; Gao, Xin

    2014-06-01

    Despite significant advances in automated nuclear magnetic resonance-based protein structure determination, the high numbers of false positives and false negatives among the peaks selected by fully automated methods remain a problem. These false positives and negatives impair the performance of resonance assignment methods. One of the main reasons for this problem is that the computational research community often considers peak picking and resonance assignment to be two separate problems, whereas spectroscopists use expert knowledge to pick peaks and assign their resonances at the same time. We propose a novel framework that simultaneously conducts slice picking and spin system forming, an essential step in resonance assignment. Our framework then employs a genetic algorithm, directed by both connectivity information and amino acid typing information from the spin systems, to assign the spin systems to residues. The inputs to our framework can be as few as two commonly used spectra, i.e., CBCA(CO)NH and HNCACB. Different from the existing peak picking and resonance assignment methods that treat peaks as the units, our method is based on 'slices', which are one-dimensional vectors in three-dimensional spectra that correspond to certain ([Formula: see text]) values. Experimental results on both benchmark simulated data sets and four real protein data sets demonstrate that our method significantly outperforms the state-of-the-art methods while using a less number of spectra than those methods. Our method is freely available at http://sfb.kaust.edu.sa/Pages/Software.aspx.

  1. First arrival time picking for microseismic data based on shearlet transform

    Science.gov (United States)

    Cheng, Yao; Li, Yue; Zhang, Chao

    2017-03-01

    Automatic identification and first arrival time picking of microseismic data play an important role in microseismic monitoring technology, and it is the precondition for real-time microseismic hypocenter location. This paper presents a novel first arrival time picking method based on shearlet transform (ST), which aims to get satisfactory results in low signal-to-noise ratio data. The ST is used to decompose noisy microseismic data. By the coefficient differences between the signal and noise at fine scales, the signal points can be preliminarily selected from the noise. To further improve the accuracy of the signal recognition, a correction to the selected signal points is made by utilizing the scale correlation between adjacent scales. The realization of the correction depends on the distances between the signal points at one scale and those at its adjacent scale. After the correction, the moment of the first identified signal point is the first arrival time. This proposed method can produce a superior performance in the accuracy of the first arrival time picking, compared with the other methods, as demonstrated using synthetic and field microseismic data. The actual picking performance of the method is further verified by receiver operating characteristic curves.

  2. A Normative Study of the Person Picking an Apple from a Tree (PPAT) Assessment

    Science.gov (United States)

    Bucciarelli, Amy

    2011-01-01

    The Person Picking an Apple from a Tree (PPAT) is an art therapy assessment task that is scored using the Formal Elements Art Therapy Scale (FEATS) to identify a client's mental health symptoms and progress in art therapy. Normative data are needed to empirically validate assumptions about the PPAT. This report summarizes a normative study of the…

  3. DeepPicker: A deep learning approach for fully automated particle picking in cryo-EM.

    Science.gov (United States)

    Wang, Feng; Gong, Huichao; Liu, Gaochao; Li, Meijing; Yan, Chuangye; Xia, Tian; Li, Xueming; Zeng, Jianyang

    2016-09-01

    Particle picking is a time-consuming step in single-particle analysis and often requires significant interventions from users, which has become a bottleneck for future automated electron cryo-microscopy (cryo-EM). Here we report a deep learning framework, called DeepPicker, to address this problem and fill the current gaps toward a fully automated cryo-EM pipeline. DeepPicker employs a novel cross-molecule training strategy to capture common features of particles from previously-analyzed micrographs, and thus does not require any human intervention during particle picking. Tests on the recently-published cryo-EM data of three complexes have demonstrated that our deep learning based scheme can successfully accomplish the human-level particle picking process and identify a sufficient number of particles that are comparable to those picked manually by human experts. These results indicate that DeepPicker can provide a practically useful tool to significantly reduce the time and manual effort spent in single-particle analysis and thus greatly facilitate high-resolution cryo-EM structure determination. DeepPicker is released as an open-source program, which can be downloaded from https://github.com/nejyeah/DeepPicker-python.

  4. A Port-Hamiltonian Approach to Visual Servo Control of a Pick and Place System

    NARCIS (Netherlands)

    Dirksz, Daniel A.; Scherpen, Jacquelien M. A.; Steinbuch, Maarten

    In this paper, we take a port-Hamiltonian approach to address the problem of image-based visual servo control of a pick and place system. Through a coordinate transformation and a passive interconnection between mechanical system and camera dynamics we realize a closed-loop system that is

  5. Pick-up ion pressure gradients modulating the solar wind dynamics

    Science.gov (United States)

    Fahr, Hans J.; Fichtner, Horst

    1995-01-01

    Neutral interstellar atoms penetrate deeply into the inner heliosphere before they become ionized by various processes. As ions they are picked-up by the frozen-in magnetic fields and are convected outwards with the solar wind plasma. Thereby the primary plasma flow is mass, momentum, and energy-loaded. The dynamics of the distant multi-constituent solar wind is, however, not solely determined by these loading processes, but is also affected by the wave-mediated pick-up ion pressure gradients derivable from the pick-up ion distribution function. The action of the radial components of these pressures essentially counter balances the decelerating effect of the solar wind momentum loading, diminishing strongly the deceleration of the distant solar wind. Furthermore the latitudinal components of the pick-up ion pressures induce latitudinal forces acting on the multiconstituent solar plasma outflow and inducing nonradial bulk flow components. The enforced nonradial outflow geometry on the upwind hemisphere may partly be responsible for the magnetic flux deficit which was claimed since several years in the PIONEER-10 magnetic flux data.

  6. Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice

    NARCIS (Netherlands)

    Acuna, Mariana; Gonzalez-Hodar, Lila; Amigo, Ludwig; Castro, Juan; Gabriela Morales, M.; Cancino, Gonzalo I.; Groen, Albert K.; Young, Juan; Francisco Miquel, Juan; Zanlungo, Silvana

    Background & Aims: Niemann-Pick C2 (NPC2) is a lysosomal protein involved in the egress of low-density lipoprotein-derived cholesterol from lysosomes to other intracellular compartments. NPC2 has been detected in several tissues and is also secreted from the liver into bile. We have previously shown

  7. MgB2 magnetometer with a directly coupled pick-up loop

    NARCIS (Netherlands)

    Portesi, C.; Mijatovic, D.; Veldhuis, D.; Brinkman, A.; Monticone, E.; Gonnelli, R.S.

    2006-01-01

    magnetometer with a directly coupled pick-up loop. We used an all in situ technique for fabricating magnesium diboride films, which consists of the co-evaporation of B and Mg by means of an e-gun and a resistive heater respectively. Consequently, we realized the superconducting device, which incorpo

  8. Movement strategy and performance in a high-volume order picking workstation

    NARCIS (Netherlands)

    Könemann, R.; Bosch, T.; Looze, M. de

    2012-01-01

    The design of a work station generally prescribes a global movement pattern of the operator, but also leaving some degrees of freedom regarding movement strategy. For a specific order picking work station, we studied the movement strategies, the underlying factors and its impact on performance. Eigh

  9. Description of third instar larvae of Anastrepha curitis, Anastrepha pickeli and Anastrepha pulchra (Diptera: Tephritidae)

    Science.gov (United States)

    We describe and illustrate for the first time the third instar larvae of three Anastrepha species, Anastrepha pickeli Lima, Anastrepha pulchra Stone, and Anastrepha curitis Stone, and also the second instar of A. curitis. Internal structures, such as the cephalopharyngeal skeleton and spiracles, and...

  10. Modeling and Scaling of Hysteresis in Magnetic Materials. Frequency, Pick of Induction and Temperature Dependence

    CERN Document Server

    Sokalski, Krzysztof Z

    2015-01-01

    Recently introduced model of magnetic hysteresis was extended into set of the following features: frequency, pick of induction and temperature of specimen. Group theoretical classification of hysteresis loops' sets is presented. An effect analogous to the Zeeman splitting has been revealed in the set of the all hysteresis loops.

  11. Design study of a resonant Schottky pick-up for the Rare-RI Ring project

    Energy Technology Data Exchange (ETDEWEB)

    Suzaki, F., E-mail: suzaki@ribf.riken.jp [Department of Physics, Saitama University, Saitama 338-8570 (Japan); Zenihiro, J. [RIKEN Nishina Center, RIKEN, Wako, Saitama 351-0198 (Japan); Yamaguchi, T., E-mail: yamaguti@phy.saitama-u.ac.jp [Department of Physics, Saitama University, Saitama 338-8570 (Japan); Ozawa, A. [Institute of Physics, University of Tsukuba, Ibaraki 305-8571 (Japan); Uesaka, T.; Wakasugi, M.; Yamada, K.; Yamaguchi, Y. [RIKEN Nishina Center, RIKEN, Wako, Saitama 351-0198 (Japan)

    2013-12-15

    Highlights: • The heavy-ion storage ring project, the Rare-RI Ring, is ongoing at the RIKEN RI Beam Factory. • The Rare-RI Ring will enable precision isochronous mass spectrometry of r-process nuclei. • A resonant Schottky pick-up will be used for the precise tuning of isochronous optics of the storage ring. • Simulation results of 3D electromagnetic field calculations show a high sensitivity of stored single-ion detection. -- Abstract: The new heavy-ion storage ring project Rare-RI Ring at the RIKEN RI Beam Factory launched in 2012 aims at precision isochronous mass spectrometry for single ions of exotic nuclides. To precisely tune the storage-ring ion optical conditions to the isochronous field setting, Schottky noise pick-up technique will be employed. Pillbox-type resonant cavity, similar to the Schottky pick-up system successfully operating at the experimental storage ring ESR at GSI, is adopted for the pick-up probe. To determine the design values of the cavity, we systematically performed a simulation study of three-dimensional electromagnetic field calculations in the high frequency region. High shunt impedance obtained in the simulation will enable us to detect stored single ions with charge down to q≃15.

  12. The Value of Inaccurate Advance Time Window Information in a Pick-up and Delivery Problem

    NARCIS (Netherlands)

    F.J. Srour (Jordan); N.A.H. Agatz (Niels); J. Oppen (Johan)

    2014-01-01

    textabstractWe examine different routing strategies to cope with inaccurate time window in- formation in the context of a dynamic pick-up and delivery problem with time windows. Our experiments show that advance information, even if inaccurate, can provide benefits from a planning perspective. We

  13. The Effect of Slot-Code Optimization in Warehouse Order Picking

    Directory of Open Access Journals (Sweden)

    Andrea Fumi

    2013-07-01

    most appropriate material handling resource configuration. Building on previous work on the effect of slot-code optimization on travel times in single/dual command cycles, the authors broaden the scope to include the most general picking case, thus widening the range of applicability and realising former suggestions for future research.

  14. Determining The Optimal Order Picking Batch Size In Single Aisle Warehouses

    NARCIS (Netherlands)

    T. Le-Duc (Tho); M.B.M. de Koster (René)

    2002-01-01

    textabstractThis work aims at investigating the influence of picking batch size to average time in system of orders in a one-aisle warehouse under the assumption that order arrivals follow a Poisson process and items are uniformly distributed over the aisle's length. We model this problem as an M

  15. Pick-N Multiple Choice-Exams: A Comparison of Scoring Algorithms

    Science.gov (United States)

    Bauer, Daniel; Holzer, Matthias; Kopp, Veronika; Fischer, Martin R.

    2011-01-01

    To compare different scoring algorithms for Pick-N multiple correct answer multiple-choice (MC) exams regarding test reliability, student performance, total item discrimination and item difficulty. Data from six 3rd year medical students' end of term exams in internal medicine from 2005 to 2008 at Munich University were analysed (1,255 students,…

  16. A constrained Nevanlinna-Pick interpolation problem for matrix-valued functions

    NARCIS (Netherlands)

    Ball, J.A.; Bolotnikov, V.; ter Horst, S.

    2010-01-01

    Recent results of Davidson-Paulsen-Raghupathi-Singh give necessary and sufficient conditions for the existence of a solution to the Nevanlinna-Pick interpolation problem on the unit disk with the additional restriction that the interpolant should have the value of its derivative at the origin equal

  17. The hidden Niemann-Pick type C patient : Clinical niches for a rare inherited metabolic disease

    NARCIS (Netherlands)

    Hendriksz, Christian J.; Anheim, Mathieu; Bauer, Peter; Bonnot, Olivier; Chakrapani, Anupam; Corvol, Jean-Christophe; de Koning, Tom J.; Degtyareva, Anna; Dionisi-Vici, Carlo; Doss, Sarah; Duning, Thomas; Giunti, Paola; Iodice, Rosa; Johnston, Tracy; Kelly, Dierdre; Kluenemann, Hans-Hermann; Lorenzl, Stefan; Padovani, Alessandro; Pocovi, Miguel; Synofzik, Matthis; Terblanche, Alta; Bergh, Florian Then; Topcu, Meral; Tranchant, Christine; Walterfang, Mark; Velten, Christian; Kolb, Stefan A.

    2017-01-01

    Background: Niemann-Pick disease type C (NP-C) is a rare, inherited neurodegenerative disease of impaired intracellular lipid trafficking. Clinical symptoms are highly heterogeneous, including neurological, visceral, or psychiatric manifestations. The incidence of NP-C is under-estimated due to unde

  18. Ataxia, dystonia and myoclonus in adult patients with Niemann-Pick type C

    NARCIS (Netherlands)

    Koens, L. H.; Kuiper, A.; Coenen, M. A.; Elting, J. W. J.; de Vries, J. J.; Engelen, M.; Koelman, J. H. T. M.; van Spronsen, F. J.; Spikman, J. M.; de Koning, T. J.; Tijssen, M. A. J.

    2016-01-01

    Background: Niemann-Pick type C (NP-C) is a rare autosomal recessive progressive neurodegenerative disorder caused by mutations in the NP-C 1 or 2 gene. Besides visceral symptoms, presentation in adolescent and adult onset variants is often with neurological symptoms. The most frequently reported pr

  19. Cherry Picking Robot Vision Recognition System Based on OpenCV

    Directory of Open Access Journals (Sweden)

    Zhang Qi Rong

    2016-01-01

    Full Text Available Through OpenCV function, the cherry in a natural environment image after image preprocessing, color recognition, threshold segmentation, morphological filtering, edge detection, circle Hough transform, you can draw the cherry’s center and circular contour, to carry out the purpose of the machine picking. The system is simple and effective.

  20. MgB2 magnetometer with directly coupled pick-up loop

    NARCIS (Netherlands)

    Portesi, C.; Mijatovic, D.; Veldhuis, Dick; Brinkman, Alexander; Monticone, E.; Gonnelli, R.S.

    2006-01-01

    magnetometer with a directly coupled pick-up loop. We used an all in situ technique for fabricating magnesium diboride films, which consists of the co-evaporation of B and Mg by means of an e-gun and a resistive heater respectively. Consequently, we realized the superconducting device, which

  1. What Skills and Tactics Are Needed to Play Adult Pick-Up Basketball Games?

    Science.gov (United States)

    Wang, Jianyu; Liu, Wenhao; Moffit, Jeffrey

    2010-01-01

    The purpose of this study was to examine skill levels and performance patterns of regular players of pick-up basketball games. By a survey, 65 participants were identified as regular players and participated in the study. An observational instrument used to analyze game performance of the participants was developed and both content and construct…

  2. White Speck, A Dye Defect in Mechanically and Hand Picked Cottons

    Science.gov (United States)

    The textile industry is often caught off guard by white specks showing up in dyed fabrics. The current grading system does not always pick up the level of maturity that causes white specks. Research using international cottons is aimed at finding high-speed measurement systems that can be used to ...

  3. 12 CFR 583.15 - Parent company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Parent company. 583.15 Section 583.15 Banks and... SAVINGS AND LOAN HOLDING COMPANIES § 583.15 Parent company. The term parent company means any company which directly or indirectly controls any other company or companies....

  4. Organizational architecture of multinational companies

    OpenAIRE

    Sikorová, Lenka

    2017-01-01

    The main goal of the bachelor thesis Organizational Architecture of Multinational Companies is to elaborate the overview of organizational structures that are used by modern global companies. The thesis contains an analysis of such companies development, principles of functioning, pros and cons and the opportunities which these brings. It also contains a description of the basic concepts associated with organizational architecture such as globalization, multinational companies and organizatio...

  5. The effects of environmental enrichment devices on feather picking in commercially housed Pekin ducks.

    Science.gov (United States)

    Colton, S; Fraley, G S

    2014-09-01

    Like other poultry species, Pekin ducks occasionally show an auto-mutilation behavior referred to as feather picking. Self-picking can lead to further pecking by conspecifics and ultimately to reduced feather quality and poor overall health of the bird. Although the reasons underlying feather picking are not clear, it appears to occur when the ducks are transitioning between downy feathers and adult plumage, between 17 and 22 d of age. We hypothesized that giving Pekin ducks a substitute outlet for this behavior in the form of environmental enrichment devices (EED) would decrease feather picking and improve feather quality and duck health and welfare. The EED were plastic Wiffle-style balls, each threaded with 4 zip-ties. In the first experiment, we set out to determine that placement of EED would not induce fear or harmful behaviors. Five barns were each divided into 2 pens, holding an average combined total of approximately 4,500 ducks with one pen per barn used as control. Upon placement of the EED in one pen per barn, both pens were videotaped for a total of 2 h per day. The physical characteristics of 100 ducks per pen were scored at age 7, 21, 28, and 35. Results showed a decrease (P = 0.034) in both self-picking and conspecific-pecking in pens with EED compared with pens without EED. Although no differences in body condition scores were observed at 7 d of age, by d 21 ducks with EED showed better (P = 0.021) feather quality and cleanliness scores compared with ducks without EED. In a second experiment, we set out to determine if ducks had a color preference for blue/green, red, or white EED. Again, ducks with EED showed reduced (P = 0.038) feather picking compared with ducks without EED. Ducks interacted considerably more (P = 0.00089) frequently with blue/green EED then either red or white EED. These results suggest that providing environmental enrichment may minimize feather picking and improve feather quality and duck welfare.

  6. The effects of brief cognitive-behaviour therapy for pathological skin picking: A randomized comparison to wait-list control.

    Science.gov (United States)

    Schuck, Kathrin; Keijsers, Ger P J; Rinck, Mike

    2011-01-01

    Thirty-four college students suffering from pathological skin picking were randomly assigned to a four-session cognitive-behavioural treatment (n=17) or a waiting-list condition (n=17). Severity of skin picking, psycho-social impact of skin picking, strength of skin-picking-related dysfunctional cognitions, and severity of skin injury were measured at pre-, post-, and two-months follow-up assessment. Participants in the treatment condition showed a significantly larger reduction on all measured variables in comparison to the waiting-list condition. The obtained effect sizes for the outcome measures were large, ranging from .90 to 1.89. Treatment effects were maintained at follow-up. In conclusion, cognitive-behavioural therapy, even in brief form, constitutes an adequate treatment option for pathological skin-picking behaviour.

  7. IMPLEMENTATION OF QUALITATIVE RULES IN COMPANY`S INFORMATION MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Anna WOLNOWSKA

    2012-07-01

    Full Text Available In the article there were presented chosen issues of quality management. Important role of information and work processes in companies were emphasized . Based on eight rules of quality management, TQM standards and ideas of discipline pioneers like Deming, Juran, Crosby and Shewart, author has constructed way of using chosen rules and assumptions to company`s information circulation. Analogy, suggested by author, has not only emphasized importance of information as a company`s resource, but also has pointed to possibility of improving ways of managing this information.

  8. Systematic approach to modernizing the production company

    Directory of Open Access Journals (Sweden)

    Irina Valeryevna Makarova

    2011-06-01

    Full Text Available This paper discusses development of modernization processes in the Russian industrial enterprises. The object of the current study is the JSC "Perm Company of petroleum machinery-producing industry". It has been manufacturing oilfield service products of various kinds. It is shown that the impact of modernization on the enterprise depends not only on the local effectiveness of selected solutions, but also on the overall strategy of sustainable development. Modernization is a strategic planning tool. Taking into account the need for a comprehensive approach to strategic development and modernization, the top five stages of the development strategy of the company were mentioned: 1 analysis of internal and external environment; 2 definition of the mission and goals; 3 choice of strategy and baseline scenarios; 4 development of basic strategy; 5 implementation of the strategy. At each stage, methods and tools for strategic planning, as well as the tools of modernization are defined. The relationship between modernization and development strategy of the company is shown. It was revealed that an integrated approach to the modernization and incremental implementation are the basics for the use of a hierarchical system of optimization models to describe the process of manufacturing company modernization. As the target model of the upper level, financial performance of the company is defined. This approach has the following advantages over the point upgrading - reducing the probability of omission of important limitations and ineffective use of resources during the transition to modernization of the company. Basing on the main strategic goals, main directions and tasks of modernization, which are integrated into the tree ends were formed. A thesis was substantiated that he essence of modernization lies in the continuity of mutually complex processes of improving all its directions. For the JSC "Perm Company of petroleum machinery-producing industry

  9. Organizational architecture of multinational company

    OpenAIRE

    Vrbová, Tereza

    2012-01-01

    The Bachelor's Thesis ,,Organizational architecture of multinational company" sets the target to analyse organizational structures used in multinational companies at present. In the teoretical section is briefly described development of this subject, basic concepts associated with organizational architecture such as globalization, multinational companies and organizational architecture. I also generalized main characteristics of organizational forms and describe their pros and cons. The pract...

  10. 政府干预、地方国有企业募资变更后投向与公司价值%Government Intervention, the Investment after the Changes of Committed Investment Orientation of Local State-owned Companies and the Companies' Value

    Institute of Scientific and Technical Information of China (English)

    曹春方

    2012-01-01

    以往的文献很少关注募资变更之后的投向,从而使得募资变更如何导致公司价值下降成为“黑箱”。本文选取2000—2008年地方国有上市公司为样本,从政府干预下募资变更后投向的角度解开部分“黑箱”。我们从晋升激励、财政激励和社会稳定等方面构建政府多重目标的干预指数,发现政府干预越强,募资变更几率越大;政府干预下公司募资变更后更易投向固定投资,最终降低公司价值。进一步发现,固定投资的资金是否来自募资变更并不能影响公司价值,降低公司价值的关键原因在于政府干预;政府干预之下公司进行的募资变更和固定投资均降低了公司价值,而募资变更是政府干预下公司进行固定投资的主要途径之一。本文从募资变更投向角度揭示了政府对企业“掠夺之手”的具体路径,有助于加深我们对政府干预企业的认识。%Raising money through stock issuance is an important capital source of listed companies' invest- ments. However, many companies' investments are not according to the commitment in the stock issue prospectus. Although considerable literatures found that the changes ofcommitted investment orientation can cause the reduction of companies' value, the researchers have paid little attention to the investments after the orientation changes, which turns the pathway of committed investment orientation's changes reducing companies' value into a "black box". By observing the data of local state-owned listed companies from the year 2000 to 2008, this paper tries to part- ly unlock the "black box" from the perspective of investment after the changes of committed investment orientation. Local governments concern about the officials' promotion, fiscal revenue and social stability. So, local govern- ments tend to intervene in the enterprises under the above incentives. And the local state

  11. Antioxidant Therapies for Ulcerative Dermatitis: A Potential Model for Skin Picking Disorder.

    Science.gov (United States)

    George, Nneka M; Whitaker, Julia; Vieira, Giovana; Geronimo, Jerome T; Bellinger, Dwight A; Fletcher, Craig A; Garner, Joseph P

    2015-01-01

    Skin Picking Disorder affects 4% of the general population, with serious quality of life impacts, and potentially life threatening complications. Standard psychoactive medications do not help most patients. Similarly, Mouse Ulcerative Dermatitis (skin lesions caused by excessive abnormal grooming behavior) is very common in widely used inbred strains of mice, and represents a serious animal welfare issue and cause of mortality. Treatment options for Ulcerative Dermatitis are largely palliative and ineffective. We have proposed mouse Ulcerative Dermatitis as a model for human Skin Picking Disorder based on similar epidemiology, behavior, and its comorbidity and mechanistic overlap with hair pulling (trichotillomania). We predicted that mouse Ulcerative Dermatitis would be treated by N-Acetylcysteine, as this compound is highly effective in treating both Skin Picking Disorder and Trichotillomania. Furthermore, we hypothesized that N-Acetylcysteine's mode of action is as a precursor to the production of the endogenous antioxidant glutathione in the brain, and therefore intranasal glutathione would also treat Ulcerative Dermatitis. Accordingly, we show in a heterogenous prospective trial, the significant reduction in Ulcerative Dermatitis lesion severity in mice receiving either N-acetylcysteine (oral administration) or glutathione (intranasal). The majority of mice treated with N-acetylcysteine improved slowly throughout the course of the study. Roughly half of the mice treated with glutathione showed complete resolution of lesion within 2-4 weeks, while the remainder did not respond. These findings are the first to show that the use of N-acetylcysteine and Glutathione can be curative for mouse Ulcerative Dermatitis. These findings lend additional support for mouse Ulcerative Dermatitis as a model of Skin Picking Disorder and also support oxidative stress and glutathione synthesis as the mechanism of action for these compounds. As N-Acetylcysteine is poorly tolerated

  12. Perturbations of the solar wind flow by radial and latitudinal pick-up ion pressure gradients

    Directory of Open Access Journals (Sweden)

    H. J. Fahr

    2004-06-01

    Full Text Available It has been found that pick-up ions at their dynamical incorporation into the solar wind modify the original conditions of the asymptotic solar wind plasma flow. In this respect, it has meanwhile been revealed in many papers that these type of solar wind modifications, i.e. deceleration and decrease of effective Mach number, are not only due to the pick-up ion loading effects, but also to the action of pick-up ion pressure gradients. Up to now only the effects of radial pick-up ion pressure gradients were considered, however, analogously but latitudinal pressure gradients also appear to be important. Here we study the effects of radial and latitudinal pick-up ion pressure gradients, occurring especially during solar minimum conditions at mid-latitude regions where slow solar wind streams change to fast solar wind streams. First, we give estimates of the latitudinal wind components connected with these gradients, and then after revealing its importance, present a more quantitative calculation of solar wind velocity and density perturbations resulting from these pressure forces. It is shown that the relative density perturbations near and in the ecliptic increase with radial distance and thus may well explain the measured non-spherically symmetric density decrease with distance. We also show that the solar wind decelerations actually seen with Voyager-1/2 are in conciliation with interstellar hydrogen densities of nH∞≥0.1cm-3, in contrast to earlier claims for nH∞=0.05cm-3.

  13. Prevalence of eating disorders and picking/nibbling in elderly women.

    Science.gov (United States)

    Conceição, Eva M; Gomes, Fabiana V S; Vaz, Ana R; Pinto-Bastos, Ana; Machado, Paulo P P

    2017-07-01

    The aim of this study was to examine the point prevalence of eating disorders and picking/nibbling in elderly women. This was a two-stage epidemiological study that assessed 342 women aged 65-94 years old. In Stage 1, the following screening measures were used to identify possible cases: the Mini-Mental State Examination, to screen and exclude patients with cognitive impairment; Weight Concerns Scale; SCOFF (Sick, Control, One, Fat, Food) Questionnaire; Eating Disorder Examination Questionnaire-dietary restraint subscale; and three questions to screen for picking/nibbling and night eating syndrome. Women selected for Stage 2 (n = 118) were interviewed using the diagnostic items of the Eating Disorder Examination. According to the DSM-5, the prevalence of all eating disorders was 3.25% (1.83-5.7, 95% C.I.). Prevalence of binge-eating disorder was 1.68% (0.82-3.82, 95% C.I.), of other specified feeding or eating disorders was 1.48% (0.63-3.42, 95% C.I.), and of bulimia nervosa 0.3% (.05-1.7, 95% C.I.)]. Binge-eating episodes were reported by 5.62% of women. No cases of anorexia nervosa or night eating syndrome were identified. The prevalence of picking/nibbling was 18.9%. Picking/nibbling was associated with increased body mass index (t(322) = -3.28, p eating episodes (χ(2) (1) = 5.65, p eating disorders on elderly Portuguese women were comparable to those found on young women. Our data support the literature that suggests that binge-eating disorder is particularly prevalent in older adults. Picking/nibbling was the most prevalent eating behavior and we provide further evidence for its association with weight and disordered eating. © 2017 Wiley Periodicals, Inc.

  14. Taboo search algorithm for item assignment in synchronized zone automated order picking system

    Science.gov (United States)

    Wu, Yingying; Wu, Yaohua

    2014-07-01

    The idle time which is part of the order fulfillment time is decided by the number of items in the zone; therefore the item assignment method affects the picking efficiency. Whereas previous studies only focus on the balance of number of kinds of items between different zones but not the number of items and the idle time in each zone. In this paper, an idle factor is proposed to measure the idle time exactly. The idle factor is proven to obey the same vary trend with the idle time, so the object of this problem can be simplified from minimizing idle time to minimizing idle factor. Based on this, the model of item assignment problem in synchronized zone automated order picking system is built. The model is a form of relaxation of parallel machine scheduling problem which had been proven to be NP-complete. To solve the model, a taboo search algorithm is proposed. The main idea of the algorithm is minimizing the greatest idle factor of zones with the 2-exchange algorithm. Finally, the simulation which applies the data collected from a tobacco distribution center is conducted to evaluate the performance of the algorithm. The result verifies the model and shows the algorithm can do a steady work to reduce idle time and the idle time can be reduced by 45.63% on average. This research proposed an approach to measure the idle time in synchronized zone automated order picking system. The approach can improve the picking efficiency significantly and can be seen as theoretical basis when optimizing the synchronized automated order picking systems.

  15. Trophic apparatus in cyprinodontiform fishes: functional specializations for picking and scraping behaviors.

    Science.gov (United States)

    Hernandez, L Patricia; Gibb, Alice C; Ferry-Graham, Lara

    2009-06-01

    Cyprinodontiforms are a diverse and speciose order that includes topminnows, pupfishes, swordtails, mosquitofishes, guppies, and mollies. Sister group to the Beloniformes and Atheriniformes, Cyprinodontiformes contains approximately twice the number of species of these other two orders combined. Recent studies suggest that this group is well suited to capturing prey by "picking" small items from the water surface, water column, and the substrate. Because picking places unusual performance demands on the feeding apparatus, this mode of prey capture may rely upon novel morphological modifications not found in more widespread ram- or suction-based feeding mechanisms. To assess this evolutionary hypothesis, we describe the trophic anatomy of 16 cyprinodontiform species, selected to broadly represent the order as well as capture intrageneric variation. The group appears to have undergone gradual morphological changes to become increasingly specialized for picking and scraping behaviors. We also identify a suite of functional characters related to the acquisition of a novel and previously undescribed mechanism of premaxillary protrusion and retraction, including: modification of the "premaxillomandibular" ligament (which connects each side of the premaxilla to the ipsilateral mandible, or lower jaw), a novel architecture of the ligaments and bony elements that unite the premaxillae, maxillae and palatine bones, and novel insertions of the adductor muscles onto the jaws. These morphological changes to both the upper and lower jaws suggest an evolutionary trend within this group toward increased reliance on picking individual prey from the water column/substrate or for scraping encrusting material from the substrate. We propose that the suite of morphological characters described here enable a functional innovation, "picking," which leads to novel trophic habits.

  16. Antioxidant Therapies for Ulcerative Dermatitis: A Potential Model for Skin Picking Disorder.

    Directory of Open Access Journals (Sweden)

    Nneka M George

    Full Text Available Skin Picking Disorder affects 4% of the general population, with serious quality of life impacts, and potentially life threatening complications. Standard psychoactive medications do not help most patients. Similarly, Mouse Ulcerative Dermatitis (skin lesions caused by excessive abnormal grooming behavior is very common in widely used inbred strains of mice, and represents a serious animal welfare issue and cause of mortality. Treatment options for Ulcerative Dermatitis are largely palliative and ineffective. We have proposed mouse Ulcerative Dermatitis as a model for human Skin Picking Disorder based on similar epidemiology, behavior, and its comorbidity and mechanistic overlap with hair pulling (trichotillomania. We predicted that mouse Ulcerative Dermatitis would be treated by N-Acetylcysteine, as this compound is highly effective in treating both Skin Picking Disorder and Trichotillomania. Furthermore, we hypothesized that N-Acetylcysteine's mode of action is as a precursor to the production of the endogenous antioxidant glutathione in the brain, and therefore intranasal glutathione would also treat Ulcerative Dermatitis. Accordingly, we show in a heterogenous prospective trial, the significant reduction in Ulcerative Dermatitis lesion severity in mice receiving either N-acetylcysteine (oral administration or glutathione (intranasal. The majority of mice treated with N-acetylcysteine improved slowly throughout the course of the study. Roughly half of the mice treated with glutathione showed complete resolution of lesion within 2-4 weeks, while the remainder did not respond. These findings are the first to show that the use of N-acetylcysteine and Glutathione can be curative for mouse Ulcerative Dermatitis. These findings lend additional support for mouse Ulcerative Dermatitis as a model of Skin Picking Disorder and also support oxidative stress and glutathione synthesis as the mechanism of action for these compounds. As N-Acetylcysteine is

  17. Research on Vision Measurement and Obstacle Avoidance Control System of Picking Robot Based on Embedded System%嵌入式采摘机器人视觉测量与避障控制系统研究

    Institute of Scientific and Technical Information of China (English)

    孙承庭; 胡平

    2016-01-01

    采摘机器人拥有自主收集信息并进行有效判断的能力,可以独立完成对果实的采摘作业,对满足水果种植需求、减小水果种植的劳动力投入及降低生产成本有着很重要的实际应用价值。为此,以嵌入式 ARM 智控系统为基础平台,设计了采摘机器人视觉测量与避障控制系统。该系统集机器视觉、视觉传感感知、伺服电机驱动和ARM智控模块于一体,建立了采摘机器人采摘运动学的数学模型,并通过 BP 网络神经型迭代学习算法测量果实的距离和球心坐标,对成熟果实进行精准识别和定位采摘。试验结果表明:采摘机器人能准确地进行自主采摘,成功率比较高,躲避障碍物的能力很强,更适合在复杂未知的果园中进行收获作业。%Harvesting robot has the ability to collect information and carry out effective judgment .It can be used to com-plete the picking of fruit .It is very important to have a very important practical application value for fruit growing de-mand, reducing the labor input and reducing production cost .This paper takes the embedded intelligence control system as the basic platform to design and research the picking robot vision measurement and obstacle avoidance control system , the system in machine vision , sensory perception , servo motor drive and arm intellectual control module in one , estab-lished picking picking robot kinematics mathematical model , and through BP neural network type iterative learning algo-rithm for measuring fruit distance and center coordinates , to mature fruits were accurate identification and localization of picking .The experimental results show that the picking robot can carry out self picking accurately , the success rate is relatively high , and the ability of avoiding obstacles is also very strong , and it is more suitable for harvesting operations in complex unknown orchard .

  18. PICK1蛋白C端酸性区域对其功能的调节%C-terminal Acidic Region Regulates PICK1 Function

    Institute of Scientific and Technical Information of China (English)

    贾原; 黄玉民; 刘俊林; 石亚伟

    2010-01-01

    蛋白激酶C相互作用蛋白1(protein interacting with C kinase l,PICKl)是调节AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)受体在细胞膜上的数量与分布,引起 LTP与LTD现象的重要蛋白.本文利用基因克隆、荧光光谱以及免疫分析等方法,分析了PICK1蛋白C末端酸性区对BAR结构域与膜脂结合能力以及PICK1分子内BAR(Bin/amphiphysin/RVS)结构域与PDZ结构域相互作用的影响,研究了钙离子结合C末端酸性区后对上述相互作用的调节.结果显示,C末端酸性区的存在使BAR结构域与膜脂的结合能力减弱大约10倍,但PICK1分子内的BAR与PDZ结构域的相互作用与不含C末端的酸性区相比增强了大约4倍.另一方面,C末端酸性区的存在,伴随钙离子浓度的提高,有助于增强BAR与膜脂的结合,却削弱了PDZ和BAR结构域的作用.当钙离子浓度增加到500 μmoL/L时,BARC的脂质结合能力以及和PDZ的亲和力与不合酸性区相当.

  19. The Italian Seismic Bulletin: strategies, revised pickings and locations of the central Italy seismic sequence

    Directory of Open Access Journals (Sweden)

    Alessandro Marchetti

    2016-12-01

    Full Text Available The central Italy seismic sequence, started with the Mw = 6.0 Amatrice earthquake on August 24th 2016, is the first significant one after the Italian Seismic Bulletin (BSI changed its analysis strategies in 2015. These new strategies consist on the release of the BSI every four months, the review of the events with ML ≥ 1.5 and the priority on the review of events with ML ≥ 3.5. Furthermore, in the last year we improved the bulletin tools and made possible the analysis of all the stations whose data are stored in the European Integrated Data Archive (EIDA. The new procedures and software utilities allowed, during the first month of 2016 emergency, to integrate, in the Bulletin, the temporary stations installed by the emergency group SISMIKO, both in real–time transmission and in stand-alone recording. In the early days of the sequence many of the BSI analysts were engaged in the monitoring room shifts, nevertheless at the end of August all events occurred in those days with ML ≥ 4 were analyzed; the largest event recovered and localized is a ML = 4.5 event immediately following the main shock. In September 2016, 83 events with ML ≥ 3.5 were analyzed and re-checked, the number of pickings greatly improved. The focal mechanism of the main shock was evaluated using first motion polarities, and compared with the available Time Domain Moment Tensors and Regional Centroid Moment Tensor. The first eight hours of the day on August 24th, the most critical for the INGV surveillance room, were carefully analyzed: the number of located events increased from 133 to 408. The magnitude of completeness, after the analysis of the BSI, has dropped significantly from about 3.5 to 2.7. The mainshock focal mechanism and the relative locations of the first 8 hours’ aftershocks give clues on the initial fault activation. The seismic sequence in November 2016 is still ongoing; it included a mainshock of Mw = 6.5 on October 30th and 3 events of magnitude

  20. INTERNATIONALIZATION STRATEGIES OF EMERGING COMPANIES: A COMPARATIVE STUDY OF BRAZILIAN CASES

    Directory of Open Access Journals (Sweden)

    Janaína Maria Bueno

    2012-01-01

    Full Text Available Over the last decade, interest has picked up as to emerging economies and their companies. This recent movement does not imply that previous theories and models are no longer applicable, however, one must analyze, in a broader comprehensive manner, a series of specific context factors and those concerning the management of this kind of company. Therefore, this paper analyzed the internationalization strategies adopted by six Brazilian companies before a set of internationalization models. A qualitative research approach was employed and in-depth interviews were conducted with corporate management level professionals. Companies were divided into three groups according to internationalization times (Group I – over ten years, Group II - between five and ten years, and Group III – under five years. Observations indicated that for Groups I and III companies the product lifecycle (Vernon, 1966 and 1979 and the eclectic paradigm (Dunning, 1980, 1988 and 2000 economic models support justifying internationalization motivations for companies’ internalization whilst the Uppsala model (Johanson and VAHLNE, 1979, 2009, at least in part explains, choice decisions concerning a few countries. As to Group II companies, the product lifecycle model is not the underlying motivation for internationalization, choices being more closely related to sector opportunities and the characteristics of both products and services.

  1. The European Model Company Act

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix

    2011-01-01

    European Company Law regulation is currently undergoing a reform. These reforms raise a number of regulatory questions, such as what should be the aims of companies' legislation, and how these aims should best be met by regulation. Many of the reforms and discussions (both on EU and national level......) on the organisation of company laws reflect an interesting paradigm shift. Whereas, previously company law was primarily focused on preventing abuse, there is now a trend towards legislation that promote commerce and satisfy the needs of business. This means that the goal of economic efficiency is having...... an increasing influence on the framing of company legislation, such as the choice between mandatory or default rules. This article introduces the project 'European Company Law and the choice of Regulatory Method' which is carried out in collaboration with the 'European Model Company Act Group'. The project aims...

  2. CSR in TSL companies

    Directory of Open Access Journals (Sweden)

    Joanna DYCZKOWSKA

    2015-03-01

    Full Text Available TSL companies are characterized by high dynamics of an increase of incomes, and hence increased shipping. Owing to a rational policy in the area of the consolidation of production and distribution, they may boast of a better use of the means of transport. The purpose of this article is to present the activities in the area of the eco-friendly CSR aspect in the activities of TSL companies taking into consideration particularly logistic operators. The research methods used in the study include an analysis of secondary data, observations and comparative analyses. Road transport in the shipping structure comes first and it constitutes 84% of freights. In the year 2009, in Poland greenhouse gas emissions from road transport amounted to 42.5 million tons (4.84% of the EU member states and CO emissions were 41.9 million tons (analogically, 4.83% of environment pollutions in the European Union. This causes an emission of fumes into the atmosphere. The policy of sustainable development pursued by logistic operators under corporate social responsibility is a response to the abovementioned data. They take decisions concerning social and environmental aspects. The activities of TSL companies under CSR need to provide an answer to customer expectations and needs, and they have to cause an increase of competitiveness on the market. The selected four largest logistic operators conduct the following eco-friendly activities on the highest level: fume emission reports and the control of these emissions, transport of hazardous goods (ADR, voluntary services in the scope of environmental protection and cooperation with eco-friendly organizations. There are those activities which call for improvement: a limitation of the emission of fumes, waste management and sewage treatment policy.

  3. Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease.

    Science.gov (United States)

    Ottinger, Elizabeth A; Kao, Mark L; Carrillo-Carrasco, Nuria; Yanjanin, Nicole; Shankar, Roopa Kanakatti; Janssen, Marjo; Brewster, Marcus; Scott, Ilona; Xu, Xin; Cradock, Jim; Terse, Pramod; Dehdashti, Seameen J; Marugan, Juan; Zheng, Wei; Portilla, Lili; Hubbs, Alan; Pavan, William J; Heiss, John; Vite, Charles H; Walkley, Steven U; Ory, Daniel S; Silber, Steven A; Porter, Forbes D; Austin, Christopher P; McKew, John C

    2014-01-01

    In 2010, the National Institutes of Health (NIH) established the Therapeutics for Rare and Neglected Diseases (TRND) program within the National Center for Advancing Translational Sciences (NCATS), which was created to stimulate drug discovery and development for rare and neglected tropical diseases through a collaborative model between the NIH, academic scientists, nonprofit organizations, and pharmaceutical and biotechnology companies. This paper describes one of the first TRND programs, the development of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) for the treatment of Niemann-Pick disease type C1 (NPC1). NPC is a neurodegenerative, autosomal recessive rare disease caused by a mutation in either the NPC1 (about 95% of cases) or the NPC2 gene (about 5% of cases). These mutations affect the intracellular trafficking of cholesterol and other lipids, which leads to a progressive accumulation of unesterified cholesterol and glycosphingolipids in the CNS and visceral organs. Affected individuals typically exhibit ataxia, swallowing problems, seizures, and progressive impairment of motor and intellectual function in early childhood, and usually die in adolescence. There is no disease modifying therapy currently approved for NPC1 in the US. A collaborative drug development program has been established between TRND, public and private partners that has completed the pre-clinical development of HP-β-CD through IND filing for the current Phase I clinical trial that is underway. Here we discuss how this collaborative effort helped to overcome scientific, clinical and financial challenges facing the development of new drug treatments for rare and neglected diseases, and how it will incentivize the commercialization of HP-β-CD for the benefit of the NPC patient community.

  4. An open-label pilot study of N-acetylcysteine for skin-picking in Prader-Willi syndrome.

    Science.gov (United States)

    Miller, Jennifer L; Angulo, Moris

    2014-02-01

    Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder caused by an abnormality on the long arm of chromosome 15 (q11-q13) that results in a host of behavioral characteristics including excessive interest in food, skin picking, difficulty with a change in routine, and obsessive and compulsive behaviors. Skin-picking can result in serious and potentially life-threatening infections. Recent evidence suggests that the excitatory neurotransmitter glutamate is dysregulated in obsessive-compulsive behaviors, and modulation of the glutaminergic pathway may decrease compulsive behaviors, such as recurrent hair pulling or skin-picking behaviors. N-acetylcysteine (NAC), a derivative of the amino acid cysteine, is thought to act either via modulation of NMDA glutamate receptors or by increasing glutathione in pilot studies. Thirty-five individuals with confirmed PWS (ages 5-39 years, 23 females/12 males) and skin-picking behavior for more than 1 year were treated with N-acetylcysteine (Pharma-NAC®) at a dose of 450-1,200 mg/day. Skin-picking symptoms and open lesions were assessed after 12 weeks of treatment by counting and measuring lesions before and after the medication. All 35 individuals had improvement in skin-picking behaviors. Ten (29%) individuals (six males and four females) did not have complete resolution of skin-picking behavior, but had significant reduction in the number of active lesions. Longer-term, placebo-controlled trials are needed to further assess the potential benefit of this treatment.

  5. CHANGQING OILFIELD COMPANY PROMOTES COOPERATION WITH FOREIGN COMPANIES

    Institute of Scientific and Technical Information of China (English)

    Di Guanglong; Li Dongxun

    2001-01-01

    @@ PetroChina Changqing Oilfield Company has vigorously promoted cooperation with foreign companies in oil and gas exploration and development in Orodos basin. In partnership with US-based Halliburton International Inc., Baker Hughes Inc., Schlumberger Ltd. and BJ Corporation,the company has carried out acidizing and fracturing design and operation for almost 30 wells with acquisition of the equipment. The cooperation has achieved satisfactory results. At present, the company is under negotiation with Exxon-Mobil Corporation and Chevron Corporation on the cooperative natural gas development and application of Sulige and Mizhi gas fields. A large number of first-class international petroleum companies have expressed their great interest and willingness to cooperate with Changqing Oilfield Company. On 30 July, the Asian Exchange Association based in Japan sent a 24-member delegation to Changqing on its fourth tour to seek business opportunities.

  6. Foreign Company in China

    Institute of Scientific and Technical Information of China (English)

    Xue Ning

    2012-01-01

    Goodyear Formally Launched Local Production of Commercial Car Tires On October 18, Goodyear's plant in Pulandian, Dalian held a ceremony to celebrate its new 200 serial commercial car tires formally coming into the market, which indicates that Goodyear formally entered into the times of local production of commercial car tires.

  7. The advanced development of Niemann-Pick C1 Like 1%Niemann-Pick C1 Like 1研究新进展

    Institute of Scientific and Technical Information of China (English)

    朱雁飞; 李幼生; 黎介寿

    2009-01-01

    Identification and characterization of Niemann-Pick C1 Like 1 (NPC1L1) has established NPC1L1 as an essential protein in the intestinal cholesterol absorption process,and NPC1L1 is the molecular target of ezetimibe, which is a cholesterol absorption inhibitor. The expression of the gene and protein of NPC1L1 may be regulated by some nuclear receptors. Lack of NPC1L1 auses a nearly complete protection from the development of atherosclerosis in apoE-/- mice c, which provides new target for the treatment for atherosclerosis and cardiovascular disease.%Niemann-Pick C1 Like 1(NPC1L1)是肠道胆固醇吸收的关键蛋白,也是胆固醇吸收抑制剂依泽替米贝的分子作用靶点.NPC1L1的表达受一些核因子受体调控.敲除apoE-/-小鼠NPC1L1基因能显著抑制动脉粥样硬化的发生和发展,为动脉粥样硬化和冠状动脉性心脏病提供了新的治疗靶点.

  8. 齿梳式油茶果采摘机采摘执行机构的研制与试验%Development and test of picking actor in oil-tea camellia fruit picking machine of tooth comb type

    Institute of Scientific and Technical Information of China (English)

    高自成; 李立君; 李昕; 闵淑辉; 易春峰

    2013-01-01

      为了实现油茶果采摘的机械化,该文论述了齿梳式油茶果采摘机执行机构的研制和试验,重点论述了可避让式采摘头、多自由度采摘臂的设计。建立了空间坐标系,应用D-H矩阵变换,建立了采摘执行机构中采摘齿的空间运动方程。现场采摘试验表明,当齿梳式采摘头上升速度约为0.8 m/s左右,采摘头回转速度约为15 r/min时,既可以获得较高的采摘效率,又能使采摘范围内的漏摘率控制在3.2%以内,同时保证花蕾的掉落率控制在3%以内,从而验证了齿梳式油茶果采摘机的可行性。%Oil-tea camellia is one of the most important economic forest products in southern China, and it has a characteristic of whose florescence overlaps with the fruiting period. During the fruiting period, the fruits should be picked, while buds falling should be avoided. At present, the oil-tea camellia fruit picking is finished by the classical manual method that results in high cost and lower efficiency. With the promotion of the good varieties and the cultivation method of oil-tea camellia, mechanization and intellectualization of fruit picking have become an important aspect in upgrading the oil-tea industry as well as one of the important development directions of forestry machinery. This paper discussed the development and test of the picking machine of the toothcomb type from several aspects as the following. Firstly, the design of the rotary picking head and the picking arm of the machine were discussed. The picking arm, which consists of two parallel quadrilateral mechanisms connected in series, locates on the end of the picking arm. This kind of structure makes it easy to keep the posture of the picking head during the picking process. The rotary picking head consists of three parallel quadrilateral mechanisms connected in parallel, revolving around the common axis. This type of picking head can increase the picking efficiency

  9. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    DEFF Research Database (Denmark)

    Thorsen, Thor S; Madsen, Kenneth L; Rebola, Nelson

    2010-01-01

    interacting protein 1 (GRIP1). Pretreatment of cultured hippocampal neurons with FSC231 inhibited coimmunopreciptation of the AMPA receptor GluR2 subunit with PICK1. In agreement with inhibiting the role of PICK1 in GluR2 trafficking, FSC231 accelerated recycling of pHluorin-tagged GluR2 in hippocampal...... neurons after internalization in response to NMDA receptor activation. FSC231 blocked the expression of both long-term depression and long-term potentiation in hippocampal CA1 neurons from acute slices, consistent with inhibition of the bidirectional function of PICK1 in synaptic plasticity. Given...

  10. Hankel vector moment sequences and the non-tangential regularity at infinity of two variable Pick functions

    CERN Document Server

    Agler, Jim

    2011-01-01

    A Pick function of $d$ variables is a holomorphic map from $\\Pi^d$ to $\\Pi$, where $\\Pi$ is the upper halfplane. Some Pick functions of one variable have an asymptotic expansion at infinity, a power series $\\sum_{n=1}^\\infty \\rho_n z^{-n}$ with real numbers $\\rho_n$ that gives an asymptotic expansion on non-tangential approach regions to infinity. H. Hamburger in 1921 characterized which sequences $\\{\\rho_n\\} $ can occur. We give an extension of Hamburger's results to Pick functions of two variables.

  11. Quality Management Systems And Impact From Standardization In Albanian Companies

    Directory of Open Access Journals (Sweden)

    Ira Zoga Gjika

    2015-08-01

    Full Text Available The increase of competition in the local and regional markets is forcing companies to provide high quality products and services as well as to continuously improve their activities. The quality management systems and standard implementation in Albanian companies are the at the focus of this paper with the intention to evidence the actual situation and the results achieved from the certification process. The implementation of ISO standard requirements together with the assessment of the benefits deriving from it is a relatively new experience for Albanian companies and slightly developed in our economic literature. Consequently this work follows a combined approach of reviewing the relevant rich literature of the last decades with the empirical survey of some Albanian companies that have chosen ISO certification as an instrument to gain competitive advantage in the market. The analysis of factors that drive companies towards such time consuming costly and managerially- wise committed process is one of main study objectives. It is followed by the assessment of benefits deriving from this process for companies in quantitative and qualitative terms. Comparing the expected advantages from the certification with those actually obtained might assist companies themselves to improve their processes. From the other side this comparison serves as a basis for suggestions and recommendations to other companies that intend to make good use of advantages the ISO certification.

  12. The Skin Picking Impact Scale: Factor structure, validity and development of a short version.

    Science.gov (United States)

    Snorrason, Ivar; Olafsson, Ragnar P; Flessner, Christopher A; Keuthen, Nancy J; Franklin, Martin E; Woods, Douglas W

    2013-08-01

    In the present study, we examined the psychometric properties of the Skin Picking Impact Scale (SPIS; Keuthen, Deckersbach, Wilhelm et al., 2001), a 10 item self-report questionnaire designed to assess the psychosocial impact of skin picking disorder (SPD). Participants were 650 individuals who met criteria for SPD in an online survey. Exploratory and confirmatory factor analyses demonstrated a unitary factor structure with high internal consistency (α = 0.94). Consequently, we constructed an abbreviated 4-item version that retained good internal consistency (α = 0.87) and a robust factor structure. Both the short and the full versions demonstrated discriminant and convergent/concurrent validity. In conclusion, the findings indicate that both versions are psychometrically sound measures of SPD related psychosocial impact; however, some potential limitations of the full scale are discussed.

  13. Stirring, charging, and picking: hunting tactics of potamotrygonid rays in the upper Paraná River

    Directory of Open Access Journals (Sweden)

    Domingos Garrone-Neto

    Full Text Available Hunting tactics of potamotrygonid freshwater rays remain unreported under natural conditions. Three main foraging tactics of Potamotrygon falkneri and P. motoro are described here based on underwater observations in the upper Paraná River. Both species displayed similar behaviors. The most common tactic was to undulate the disc margins close to, or on, the bottom and thus stirring the substrate and uncovering hidden preys. Another tactic was to charge upon prey concentrated in the shallows. The least common tactic was to pick out prey adhered to the substrate. The first tactic is widespread in several species of marine rays in the Dasyatidae, whereas the remainder (especially picking up prey on substrata above water surface may be restricted to the Potamotrygonidae.

  14. Automatic post-picking improves particle image detection from Cryo-EM micrographs

    CERN Document Server

    Norousi, Ramin; Becker, Thomas; Beckmann, Roland; Schmid, Volker J; Tresch, Achim

    2011-01-01

    Cryo-electron microscopy (cryo-EM) studies using single particle reconstruction is extensively used to reveal structural information of macromolecular complexes. Aiming at the highest achievable resolution, state of the art electron microscopes acquire thousands of high-quality images. Having collected these data, each single particle must be detected and windowed out. Several fully- or semi-automated approaches have been developed for the selection of particle images from digitized micrographs. However they still require laborious manual post processing, which will become the major bottleneck for next generation of electron microscopes. Instead of focusing on improvements in automated particle selection from micrographs, we propose a post-picking step for classifying small windowed images, which are output by common picking software. A supervised strategy for the classification of windowed micrograph images into particles and non-particles reduces the manual workload by orders of magnitude. The method builds...

  15. Injection to the pick-up ion regime from high energies and induced ion power laws

    CERN Document Server

    Fahr, H -J; Verscharen, D

    2008-01-01

    Though pick-up ions (PUIs) are a well known phenomenon in the inner heliosphere, their phase-space distribution nevertheless is a theoretically unsettled problem. Especially the question of how pick-up ions form their suprathermal tails, extending to far above their injection energies, still now is unsatistactorily answered. Though Fermi-2 velocity diffusion theories have revealed that such tails are populated, they nevertheless show that resulting population densities are much less than seen in observations showing power-laws with a velocity index of ``-5''. We first investigate here, whether or not observationally suggested power-laws can be the result of a quasi-equilibrium state between suprathermal ions and magnetohydrodynamic turbulences in energy exchange with eachother. We demonstrate that such an equilibrium cannot be established. We furthermore show that Fermi-2 type energy diffusion in the outer heliosphere is too inefficient to determine the shape of the distribution function there. As we can show...

  16. Combinatorial optimization of order picking and export choosing for bypass type automatic stereoscopic warehouse

    Directory of Open Access Journals (Sweden)

    Jinye WANG

    Full Text Available The automatic stereo warehouse system is a storage system with multi-storey warehouse, by which the automation access and integrated automation management are realized in the computer's direct control and management. The emerging, bypass automatic stereo warehouse has gained more and more application in rapid access. The stacker's working time directly affects the efficiency of the warehouse. To improve the bypass automatic warehouse efficiency and analyze the stacker route, an integrated optimization model considering the export selection and the path picking is established. The model aims to the picking task cycle and develops the population's generating method of genetic algorithm, then solves the optimization model. The last section in this stage is the initial point of the next optimization stage, using the nearest neighbor method to find the optimal export location. Simulation and practical application show that the model and the algorithm are feasible and effective.

  17. Robust Controller Design Using the Nevanlinna-Pick Interpolation in Gyro Stabilized Pod

    Directory of Open Access Journals (Sweden)

    Bin Liu

    2010-01-01

    Full Text Available The sensitivity minimization of feedback system is solved based on the theory of Nevanlinna-Pick interpolation with degree constraint without using weighting functions. More details of the dynamic characteristic of second-order system investigated, which is determined by the location of spectral zeroes, the upper bound γ of S, the length of the spectral radius and the additional interpolation constraints. And the guidelines on how to tune the design parameters are provided. Gyro stabilized pod as a typical tracking system is studied, which is based on the typical structure of two-axis and four-frame. The robust controller is designed based on Nevanlinna-Pick interpolation with degree constraint. When both friction of LuGre model and disturbance exist, the closed-loop system has stronger disturbance rejection ability and high tracking precision. Numerical examples illustrate the potential of the method in designing robust controllers with relatively low degrees.

  18. Manipulator adaptive control by neural networks in an orange picking robot.

    Science.gov (United States)

    Cavalieri, S; Plebe, A

    1996-12-01

    The paper focuses on the use of neural networks for process identification in an orange-picking robot adaptive control system. The results that will be shown in the paper refer to a study carried out under the European Community ESPRIT project "CONNY", dealing with the application of neural networks to robotics. The aim of the research is to verify the possibility of integrating a neural identification module in a traditional system to control the movement of the manipulators of the robot. The paper illustrates integration of neural identification in the existing orange-picking robot control system, highlighting the improvement of performance obtainable. Although the proposal refers to a specific robot, it can be applied to any system with the same dynamic features.

  19. Research on inverse kinematics solution of apple picking manipulator%苹果采摘机械手的逆运动学求解研究

    Institute of Scientific and Technical Information of China (English)

    邹志勇; 韩玖胜

    2016-01-01

    为了提高苹果采摘机械手的采摘成品率,保证采摘后苹果质量,提出一种引入采摘综合因素的苹果采摘机械手的逆运动学求解方法。首先,采用Denavit-Hartenberg模型对苹果采摘机械手进行建模,并将逆运动学求解问题转化为规划问题,其中,目标函数为所求得逆运动学参数对应的机械手末端中心坐标与待求坐标欧式距离。然后,在遗传算法选择、交叉、变异算子进行全局搜索的基础上,结合非线性规划对目标函数进行局部搜索。最后,借助随机森林算法将逆运动学求解结果分为3个姿势等级。试验表明,非线性遗传算法在苹果采摘机械手的逆运动学求解上相比遗传算法精度提高了8~25 mm,随机森林算法可以很好地对其求逆结果进行优化,从而提高苹果采摘成品率。%In order to improve the stability and yield of apple picking robot , the method of inverse kinematics of picking manipulator was proposed .First, the D-H model was used to establish the model of the apple picking robot . Kinematics problem of apple picking robot was thus translated into programming problem .The objective function was the Euclidean distance between the apple picking robot coordinate and unknown coordinate .In order to obtain the in-verse kinematic parameters , the genetic algorithm was then used for global search , which included selection , cross-over and mutation operators , and non-linear programming was used for local search based on the result of genetic al-gorithm.Finally, the kinematic parameters were divided into 3 grades by random forest algorithm .Experiment showed that compared with the genetic algorithm , the algorithm proposed in the present study improved the accuracy by 8-25 mm in solution of inverse kinematics .In conclusion , the proposed method was valid for kinematics prob-lem, and thus would help improve the yield of apple picking robot .

  20. Diagnostic Process of Company Productivity

    Directory of Open Access Journals (Sweden)

    Emese Tokarˇcíková

    2009-12-01

    Full Text Available This paper deals with an actual topic of how key factors of enterprise diagnostics can help to increase company productivity. Recognition and use of relevant internal and external information in this field determines the success of the enterprise. Application of the general diagnostic model of company productivity to the net income has been a frequent problem of company practice. This problem is of profit showing, which is an inevitable precondition for long-term company development and growth. Diagnostic access of company productivity allows recognition of specific problems in greater detail, which results from the activity of each company. This article also presents an introduction to the researched area of enterprise diagnostics, which opens opportunities for other publishing activities and can lead to information exchange.

  1. An automated framework for NMR resonance assignment through simultaneous slice picking and spin system forming

    KAUST Repository

    Abbas, Ahmed

    2014-04-19

    Despite significant advances in automated nuclear magnetic resonance-based protein structure determination, the high numbers of false positives and false negatives among the peaks selected by fully automated methods remain a problem. These false positives and negatives impair the performance of resonance assignment methods. One of the main reasons for this problem is that the computational research community often considers peak picking and resonance assignment to be two separate problems, whereas spectroscopists use expert knowledge to pick peaks and assign their resonances at the same time. We propose a novel framework that simultaneously conducts slice picking and spin system forming, an essential step in resonance assignment. Our framework then employs a genetic algorithm, directed by both connectivity information and amino acid typing information from the spin systems, to assign the spin systems to residues. The inputs to our framework can be as few as two commonly used spectra, i.e., CBCA(CO)NH and HNCACB. Different from the existing peak picking and resonance assignment methods that treat peaks as the units, our method is based on \\'slices\\', which are one-dimensional vectors in three-dimensional spectra that correspond to certain (N, H) values. Experimental results on both benchmark simulated data sets and four real protein data sets demonstrate that our method significantly outperforms the state-of-the-art methods while using a less number of spectra than those methods. Our method is freely available at http://sfb.kaust.edu.sa/Pages/Software.aspx. © 2014 Springer Science+Business Media.

  2. ActiveSeismoPick3D - automatic first arrival determination for large active seismic arrays

    Science.gov (United States)

    Paffrath, Marcel; Küperkoch, Ludger; Wehling-Benatelli, Sebastian; Friederich, Wolfgang

    2016-04-01

    We developed a tool for automatic determination of first arrivals in active seismic data based on an approach, that utilises higher order statistics (HOS) and the Akaike information criterion (AIC), commonly used in seismology, but not in active seismics. Automatic picking is highly desirable in active seismics as the number of data provided by large seismic arrays rapidly exceeds of what an analyst can evaluate in a reasonable amount of time. To bring the functionality of automatic phase picking into the context of active data, the software package ActiveSeismoPick3D was developed in Python. It uses a modified algorithm for the determination of first arrivals which searches for the HOS maximum in unfiltered data. Additionally, it offers tools for manual quality control and postprocessing, e.g. various visualisation and repicking functionalities. For flexibility, the tool also includes methods for the preparation of geometry information of large seismic arrays and improved interfaces to the Fast Marching Tomography Package (FMTOMO), which can be used for the prediction of travel times and inversion for subsurface properties. Output files are generated in the VTK format, allowing the 3D visualization of e.g. the inversion results. As a test case, a data set consisting of 9216 traces from 64 shots was gathered, recorded at 144 receivers deployed in a regular 2D array of a size of 100 x 100 m. ActiveSeismoPick3D automatically checks the determined first arrivals by a dynamic signal to noise ratio threshold. From the data a 3D model of the subsurface was generated using the export functionality of the package and FMTOMO.

  3. Excoriation (skin-picking disorder: a systematic review of treatment options

    Directory of Open Access Journals (Sweden)

    Lochner C

    2017-07-01

    Full Text Available Christine Lochner,1 Annerine Roos,1 Dan J Stein2 1SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South Africa; 2SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, South Africa Abstract: Although pathological skin-picking has been documented in the medical literature since the 19th century, it has only recently been included as a distinct entity in psychiatric classification systems. In the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition and the proposed International Classification of Diseases, Eleventh Revision, excoriation (skin-picking disorder (ED, also known as neurotic excoriation, psychogenic excoriation, or dermatillomania, is described as recurrent picking of skin, leading to skin lesions and significant distress or functional impairment. ED is listed as one of the obsessive–compulsive and related disorders, given its overlap with conditions such as trichotillomania (hair-pulling disorder. Arguably, its inclusion and delineation in the diagnostic nomenclature will lead to increased awareness of the condition, more research, and ultimately in treatment advances. This systematic review aims to provide readers with an up-to-date view of current treatment options for ED. A MEDLINE search of the ED treatment literature was conducted to collate relevant articles published between 1996 and 2017. The findings indicate that a number of randomized controlled trails on ED have now been published, and that current management options include behavioral therapy (habit reversal or acceptance-enhanced behavior therapy, and medication (selective serotonin reuptake inhibitors or N-acetyl cysteine. Keywords: excoriation, skin-picking, treatment, habit reversal therapy, behavioral therapy, pharmacotherapy, systematic review

  4. The aurora sign in a patient with type B Niemann-Pick disease

    Energy Technology Data Exchange (ETDEWEB)

    Costa e. Silva, Eduardo J. da [Instituto Materno Infantil Professor Fernando Figueira, Departamento de Radiologia, Recife, Pernambuco (Brazil); IMIP, Departamento de Radiologia-Rua dos Coelhos, Recife, PE (Brazil); Cavalcanti de Albuquerque, Silvio; Queiroz Praxedes, Eduardo L. de; Amaral, Fernando J. do [Instituto Materno Infantil Professor Fernando Figueira, Departamento de Radiologia, Recife, Pernambuco (Brazil)

    2007-01-15

    The aurora sign, a sonographic sign found on the sagittal and transverse view, refers to multiple bands of ring-down artifacts posterior to the right hemidiaphragm. Parenchymal lung disease should be suspected when this is present. We report a case of type B Niemann-Pick disease with pulmonary involvement and the aurora sign on abdominal sonography. High-resolution CT of the chest showed corresponding thickened interlobular septa. (orig.)

  5. Microstructure & performance of laser cladding on pick surface of coal mining machine

    Institute of Scientific and Technical Information of China (English)

    SUN Hui-lai; ZHAO Fang-fang; ZHANG Shou-xin; QI Xiang-yang

    2006-01-01

    Laser cladding of 316 L steel powders on pick substrate of coal mining machine was conducted, and microstructure of laser cladding coating was analyzed. The micro-hardness of laser cladding coating was examined. The results show that microstructure of laser cladding zone is exiguous dentrite, and there are hard spots dispersible distribution in the laser cladding zone. Performances of erode-resistant, surface micro-hardness and wear-resistant are improved obviously.

  6. The planning of order picking in a warehouse by heuristic algorithms

    OpenAIRE

    Uršič, Jakob

    2014-01-01

    Planning of order picking is essential process in every warehouse. In this thesis, we developed a simple warehouse simulator, which allows us to do various searches on path finding for a certain amount of items for one or more robots, using the A* algorithm. Heuristic guidance of search is mainly based on heuristic evaluation. We have implemented five different heuristic estimates, which we tested experimentally on examples with different warehouse configurations and with different numbers of...

  7. Survey of finance companies, 2000

    OpenAIRE

    Karen E. Dynan; Kathleen W. Johnson; Samuel M. Slowinski

    2002-01-01

    Against a backdrop of robust economic activity, the finance company sector expanded briskly over the second half of the 1990s. The value of receivables held by finance companies in the United States rose nearly 50 percent, or about 11 percent a year, between 1996 and 2000. Business lending remained finance companies' major line of activity; the importance to the sector of consumer lending and leasing declined slightly, and the importance of real estate lending rose a bit. These and other find...

  8. Benchmarking in Mobarakeh Steel Company

    OpenAIRE

    Sasan Ghasemi; Mohammad Nazemi; Mehran Nejati

    2008-01-01

    Benchmarking is considered as one of the most effective ways of improving performance in companies. Although benchmarking in business organizations is a relatively new concept and practice, it has rapidly gained acceptance worldwide. This paper introduces the benchmarking project conducted in Esfahan's Mobarakeh Steel Company, as the first systematic benchmarking project conducted in Iran. It aims to share the process deployed for the benchmarking project in this company and illustrate how th...

  9. Identification of Company Command Competencies

    Science.gov (United States)

    2013-06-01

    45 Virtual role plays ( VRPs ) could be used to measure many of the company command competencies identified in this project. In a VRP , the user...could play the role of a Company Commander who must deal with myriad crises, challenges, and potential opportunities. In a web- enabled VRP , the user...to be concerned about. Future research should create VRPs or other engaging assessments to determine proficiency levels on the identified company

  10. Company cases Denmark

    DEFF Research Database (Denmark)

    Tølle, Martin; Pedersen, Jørgen Lindgaard

    2005-01-01

    IT - solitions. CSC wanted to buy DC to penetrate the Nordic market. Some effects can be mentioned: Employment in CSC - DK is in 2003 1,700 persons or 2,600 including other companies bought up recently. In innovation positive effects can be registered from contacts with CSC - International. Not only from access...... for government sector in Denmark. DC employed 1,000 persons and had a market share on 75 % in the market of large government institutions when it was taken over. Danish government wanted to sell DC in order to get more intensity in competion in IT - markets in general and especially in the market for public...... to technology but also from more focus on human beings and business.It has been important that CSC has respected Nordic values in worklife and that the CSC philosophy has been important and not so different from DC. The other case is from pharmaceutical industry in which Norwegian Nycomed buys DAK...

  11. The Balanced Company

    DEFF Research Database (Denmark)

    Controlling the sustainability of production processes and ethical employment of the work force in suppliers' production facilities far away from the home country has resulted in new challenges for managers. They now have to consider how important it is for customers, investors and employees to see...... that a company is respected in wider society and behaves according to ethical standards. Strategists and Leaders need to make balanced choices about long-term goals and the allocation of resources. They need to analyse, understand and adjust strategies to market, political, value and technology related changes...... in their environments. Communication specialists need to make balanced decisions which take the different value systems and assumptions of stakeholders into consideration. Change specialists need to balance the need for continuity and change. Managers need to make balanced decisions about whether to achieve goals...

  12. Marketing Strategy of Company

    OpenAIRE

    Pavlas, Vojtěch

    2009-01-01

    Cílem této diplomové práce s názvem "Marketingová strategie podniku" je nalezení vhodných nástrojů pomocí kterých bude analyzována stávající situace společnosti C&K a.s. v oblasti marketingové strategie. Pomocí aplikace nástrojů marketingu budou navžena opatření, jejichž aplikací by mělo dojít k zlepšení postavení společnosti na thu na němž se pohybuje. The main subject of this thesis named "Marketing strategy of company" is finding suitable tools which will help to analyse present situati...

  13. Acousto-optic pulse picking scheme with carrier-frequency-to-pulse-repetition-rate synchronization.

    Science.gov (United States)

    de Vries, Oliver; Saule, Tobias; Plötner, Marco; Lücking, Fabian; Eidam, Tino; Hoffmann, Armin; Klenke, Arno; Hädrich, Steffen; Limpert, Jens; Holzberger, Simon; Schreiber, Thomas; Eberhardt, Ramona; Pupeza, Ioachim; Tünnermann, Andreas

    2015-07-27

    We introduce and experimentally validate a pulse picking technique based on a travelling-wave-type acousto-optic modulator (AOM) having the AOM carrier frequency synchronized to the repetition rate of the original pulse train. As a consequence, the phase noise characteristic of the original pulse train is largely preserved, rendering this technique suitable for applications requiring carrier-envelope phase stabilization. In a proof-of-principle experiment, the 1030-nm spectral part of an 74-MHz, carrier-envelope phase stable Ti:sapphire oscillator is amplified and reduced in pulse repetition frequency by a factor of two, maintaining an unprecedentedly low carrier-envelope phase noise spectral density of below 68 mrad. Furthermore, a comparative analysis reveals that the pulse-picking-induced additional amplitude noise is minimized, when the AOM is operated under synchronicity. The proposed scheme is particularly suitable when the down-picked repetition rate is still in the multi-MHz-range, where Pockels cells cannot be applied due to piezoelectric ringing.

  14. Method proposition to set the pallet positions designated to fractioned picking orders in a warehouse

    Directory of Open Access Journals (Sweden)

    Caroline Morito Pereira

    2016-11-01

    Full Text Available Storage processes have acquired great importance in the modern supply chain, which demands better performance by warehouses in organizing goods in order to achieve high utilization of physical space and to facilitate the movement of materials. Sizing the storage area and organizing items strategically in storage positions ensures better efficiency in picking processes and customer service. In this context, this study aims to propose a method for defining the positions of pallets assigned to fractioned picking orders in a warehouse according to criteria based on popularity and turnover of the products. This method will be presented in a case study, and the pallets will be positioned in the warehouse in accordance with the results obtained. The gains in terms of order picking productivity and optimization of storage positions will then be measured. Research in this area has grown rapidly in recent years, but the combination of sizing items and classifying these items has not been closely explored. Thus, it is believed that the results could contribute to future research, bridging academic researchers and warehouse professionals.

  15. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    DEFF Research Database (Denmark)

    Holst, Birgitte; Madsen, Kenneth L; Jansen, Anna M

    2013-01-01

    Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here...... for vesicular storage of GH and possibly other hormones. The data link two BAR domain proteins to membrane remodeling processes in the secretory pathway of peptidergic endocrine cells and support an important role of PICK1/ICA69 in maintenance of metabolic homeostasis.......Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here......, we identify the lipid binding BAR (Bin/amphiphysin/Rvs) domain protein PICK1 (protein interacting with C kinase 1) as a key component early in the biogenesis of secretory vesicles in GH-producing cells. Both PICK1-deficient Drosophila and mice displayed somatic growth retardation. Growth retardation...

  16. EFFICACY OF CITALOPRAM IN TREATMENT OF PATHOLOGICAL SKIN PICKING, A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL

    Directory of Open Access Journals (Sweden)

    M Arbabi

    2008-11-01

    Full Text Available "nVarious studies suggest that selective serotonin reuptake inhibitors (SSRIs may be useful in treating pathological skin picking (PSP. This study sought to assess effectiveness of citalopram in comparison with placebo in treating PSP. Forty five individuals with PSP were recruited in a four-week, randomized clinical trial of citalopram (20 mg/day in comparison with placebo. Study measures assessing skin picking severity, mental health status, obsessive compulsive disorder and quality of life were given at baseline, weeks 2 and 4. PSP severity, general health status, obsession-compulsion severity and quality of life level were similar between two groups at baseline (P > 0.05. Treatment analyses revealed significant improvements in quality of life, general health status and obsession-compulsion severity in citalopram group compared to placebo group (P < 0.05. Mean PSP severity reduction in citalopram group was more than placebo group but this difference was not significant. Citalopram can improve general health status and quality of life in individuals with PSP but its effect on skin picking behavior doesn't differ significantly with placebo. Other trials with longer time are needed to determine the exact efficacy of citalopram on PSP

  17. Measuring the Company Performance

    Directory of Open Access Journals (Sweden)

    Ion Stancu

    2006-01-01

    Full Text Available According to the logics of the efficient capital investment, the management of the investment of the saving capital in the company’s assets must conclude, on the end of the financial year, with a plus of real value (NPV > 0. From this point of view, in this paper we suggest the usage of an investment valuation model for the assessment of the company managerial and technological performance. Supposing the book value is a proxy of the just value (of assets and operational results and supposing the capital cost is correctly estimated, we evaluate the company’s performance both by the net present value model, and also by the company’s ability to create a surplus of the invested capital (NPV >0. Our paper also aims to identify the performance of the financial breakeven point (for which NPV is at least equal to zero as the minimum acceptable level for the company’s activity. Under this critical sales point, the company goes through the undervaluation of shareholders fortune even if the company’s sales are greater than accounting breakeven point. The performance’s activity level is one which the managers recover and surpass the cost of capital, cost which stand for the normal activity benchmark. The risks of applying of our suggested model we support go down to the confidence of accounting data and of the cost of capital estimating. In spite all of this, the usage of a sensitivity analysis to search an average NPV would leads to the company’s performance valuation within investment logic with a high information power.

  18. Measuring the Company Performance

    Directory of Open Access Journals (Sweden)

    Ion Stancu

    2006-03-01

    Full Text Available According to the logics of the efficient capital investment, the management of the investment of the saving capital in the company’s assets must conclude, on the end of the financial year, with a plus ofreal value (NPV > 0. From this point of view, in this paper we suggest the usage of an investment valuationmodel for the assessment of the company managerial and technological performance. Supposing the book value is a proxy of the just value (of assets and operational results and supposing the capital cost iscorrectly estimated, we evaluate the company’s performance both by the net present value model, and also by the company’s ability to create a surplus of the invested capital (NPV >0.Our paper also aims to identify the performance of the financial breakeven point (for which NPV is at least equal to zero as the minimum acceptable level for the company’s activity. Under this critical sales point, the company goes through the undervaluation of shareholders fortune even if the company’s sales are greater than accounting breakeven point. The performance’s activity level is one which the managers recover and surpass the cost of capital, cost which stand for the normal activity benchmark.The risks of applying of our suggested model we support go down to the confidence of accounting data and of the cost of capital estimating. In spite all of this, the usage of a sensitivity analysis to search anaverage NPV would leads to the company’s performance valuation within investment logic with a high information power.

  19. Influence of new customs procedures and logistic security standards on companies competiveness – a Croatian company case study

    Directory of Open Access Journals (Sweden)

    Aleksandar Erceg

    2014-12-01

    Full Text Available In today’s global market, companies are constantly confronted with the competition on the local, national and international level. Companies therefore use a variety of strategies and tools to become and/or remain competitive. Potential areas for cost reduction in companies are supply chain management and logistic and customs procedures. Implementation of various logistic standards in supply chain management can provide significant cost savings for the company’s daily operations and thus reduce overall costs and improve the competitiveness. Using different customs procedures and logistic standards to reduce their costs and become more competitive in the market is necessary for Croatian companies. The method of using these tools is not a one-time process and requires constant efforts. Companies therefore have to be ready to improve daily to be and remain competitive. Using a variety of modern customs procedures can save their money and time, not only through these procedures, but also through better use of their employee’s time, their own vehicles and other equipment. The paper analyzes various customs procedures and logistic standards that can help companies save time and money and improve their competitiveness. In the example of Croatian company, which uses various available procedures and standards the benefits of their use are shown. Apart from bringing savings in operations, all these procedures and standards allow the company to be better, cheaper and more attractive to buyers.

  20. Changes in Caries Risk and Activity of a 9-Year-Old Patient with Niemann-Pick Disease Type C

    Directory of Open Access Journals (Sweden)

    Késsia Suênia Fidelis Mesquita-Guimarães

    2015-01-01

    Full Text Available Objective. This case report describes the changes in caries risk and activity and dental treatment of a 9-year-old patient who presented with signs and symptoms of Niemann-Pick disease type C (NPC. Treatment. The preventive dental treatment included instructions to caregivers for oral hygiene and diet. A calcium hydroxide pulpotomy and restorative dental treatments were performed in a dental office with desensitization techniques and behavioral management. The patient was attended every 3 months for the control of dental plaque biofilm, for topical fluoride application, and for observing the pulpotomized tooth. Results. The bacterial plaque biofilm was being adequately controlled by the caregiver. After 2 years, the clinical and radiographic examination of the pulpotomized tooth showed the absence of internal root resorption and bone rarefaction, and clinical examination showed tooth sensitivity, dental pain, and gingival swelling. Conclusion. The pulpotomy prevented clinical and radiographic success. Dentists must be aware of and be able to identify systemic and local aspects associated with caries risk of children with NPC disease. Furthermore, dentists must employ stringent preventive measures and provide instructions to caregivers to reduce caries risk.

  1. Social licence for the utilization of wild berries in the context of local traditional rights and the interests of the berry industry

    Directory of Open Access Journals (Sweden)

    Rainer Peltola

    2014-10-01

    Full Text Available Everyman’s right, as applied in Finland and other Nordic countries, allows the picking of natural products (wild berries, mushrooms, etc. regardless of land ownership. Harvesting and selling natural products has been an important source of income in rural areas of northern Finland. As household berry picking has more or less replaced small-scale commercial berry picking, foreign seasonal pickers are now supplying raw material for the berry industry. This has aroused vivid discussions about the limits of everyman’s right and inhabitants’ rights to local natural resources. Critics claim that commercially organized berry picking makes it difficult for inhabitants to fully use natural resources. In this article, we present the results of a survey aimed at nature-oriented, mainly northern residents of Finland and a telephone and e-mail service to which residents of northern Finland sent feedback regarding foreign berry pickers. The results of the survey and the feedback show that, in general, organized berry picking by foreign labourers is accepted if some basic guidelines or rules are respected. These guidelines may stem from local customary laws or traditions which have regulated berry picking. Another factor which would improve local acceptance and promote social licence for organized berry picking by foreign and non–local labourers is the distribution of benefits. At present, the advantages of organized berry picking are seen as benefiting stakeholders outside the local community, whereas local communities have to bear the costs: for example, increased berry picking activity in areas which they have utilized for a prolonged time, sometimes through generations.

  2. 78 FR 58571 - Maine Yankee Atomic Power Company, Connecticut Yankee Atomic Power Company, and The Yankee Atomic...

    Science.gov (United States)

    2013-09-24

    ... Atomic Power Company, Connecticut Yankee Atomic Power Company, and The Yankee Atomic Electric Company... Power Company (Maine Yankee), Connecticut Yankee Atomic Power Company (Connecticut Yankee), and the Yankee Atomic Electric Company (Yankee Atomic) (together, ``licensees'' or ``the Yankee Companies'')...

  3. Local Responsiveness in Distant Markets

    DEFF Research Database (Denmark)

    Lubinski, Christina

    2015-01-01

    Multinational corporations face the challenge of balancing global integration and local responsiveness. Localization strategies have been much debated in the literature, and scholars have suggested the 1980s as a watershed moment leading to the development of distinctly transnational companies......, the political context, and the flow of information between headquarters and subsidiaries showing how and why these companies developed into transnational entities....... on the Indian market before WWI, this article traces the competition between different Western gramophone companies and their business strategies for this economically attractive market with institutional voids and rising Indian nationalism. It addresses the specificity of the gramophone and music industry...

  4. Company Strategy Determination in Food Company Using Swot Method

    Directory of Open Access Journals (Sweden)

    Ingaldi Manuela

    2014-10-01

    Full Text Available Strategy is a high-level plan to achieve one or more goals under conditions of uncertainty. Strategy becomes necessary when it is known or suspected there are insufcient resources to achieve these goals. To choose a good strategy, it is important to check frst the strategic position of a company. The SWOT analysis is a very useful tool to do so. Everyone almost every day buys food to live. For people, it is very important to buy food with good quality at a low price. That is why the authors chose a food company to check its strategic position. In this paper, the strategic position of the chosen food company was specifed. This allowed assessing the current situation of the company and to determine the direction of its future activities. The company should use the maxi-maxi strategy.

  5. The use of data mining by private health insurance companies and customers' privacy.

    Science.gov (United States)

    Al-Saggaf, Yeslam

    2015-07-01

    This article examines privacy threats arising from the use of data mining by private Australian health insurance companies. Qualitative interviews were conducted with key experts, and Australian governmental and nongovernmental websites relevant to private health insurance were searched. Using Rationale, a critical thinking tool, the themes and considerations elicited through this empirical approach were developed into an argument about the use of data mining by private health insurance companies. The argument is followed by an ethical analysis guided by classical philosophical theories-utilitarianism, Mill's harm principle, Kant's deontological theory, and Helen Nissenbaum's contextual integrity framework. Both the argument and the ethical analysis find the use of data mining by private health insurance companies in Australia to be unethical. Although private health insurance companies in Australia cannot use data mining for risk rating to cherry-pick customers and cannot use customers' personal information for unintended purposes, this article nonetheless concludes that the secondary use of customers' personal information and the absence of customers' consent still suggest that the use of data mining by private health insurance companies is wrong.

  6. 用于Pick-and-Place的高速并联机构Par4%High Speed Parallel Robot Par4 for Pick-and-Place

    Institute of Scientific and Technical Information of China (English)

    张树君; 辛莹莹; 陈大千; 何召明; 陈芳芳

    2013-01-01

    介绍了一种用于拾取放置(Pick-and-Place)场合的四自由度并联机构.它是Delta机构的一种演化,在H4和I4并联机构的基础上发展起来的,Par4机构既保留了H4和I4并联机构的优点又克服了其缺点.通过对末端执行器的改进使其实现4个自由度,提高了机器人的力学性能和工作空间,延长了寿命,为Par4并联机器人性能的提升和实际的工程应用提供了理论依据和技术支持.

  7. Clinical evaluation of chitotriosidase enzyme activity in Gaucher and Niemann Pick A/B diseases: A retrospective study from India.

    Science.gov (United States)

    Kadali, Srilatha; Kolusu, Anusha; Sunkara, Satish; Gummadi, Maheshwar Reddy; Undamatla, Jayanthi

    2016-06-01

    Plasma chitotriosidase originates from activated macrophages and is reported to be elevated in many Lysosomal Storage Disorders. Measurement of this enzyme activity has been an available tool for monitoring therapy of Gaucher disease. The degree of elevation of chitotriosidase is useful for differential diagnosis of Gaucher disease and Niemann Pick A/B. However the potential utility of this chitotriosidase assay depends on the frequency of deficient chitotriosidase activity in a particular population. We therefore aim to study the clinical utility of this assay Gaucher and Niemann Pick A/B diseases in the backdrop of chitotriosidase deficiency in our population. The study comprises 173 patients with clinical suspicion of either Gaucher disease (n=108) or Niemann Pick A/B (n=65) and 92 healthy controls. The plasma samples of controls, Gaucher disease, and Niemann Pick A/B showed chitotriosidase deficiency of 12%, 25% and 27% respectively. The degree of elevation of chitotriosidase in Gaucher disease and Niemann Pick A/B patients is 40-326 (11,325.7±6395.4nmol/h/ml) and 7-22 folds (1192.5±463.0nmol/h/ml) respectively. In view of these findings of distinguishable fold elevation of chitotriosidase in Gaucher disease or Niemann Pick A/B, it can be a potential surrogate differential diagnostic marker for these groups of diseases, except in the patients in whom this enzyme is deficient.

  8. Design of planar pick-ups for beam position monitor in the bunch compressor at FLASH and XFEL

    Energy Technology Data Exchange (ETDEWEB)

    Angelovski, Aleksandar; Penirschke, Andreas; Jakoby, Rolf [Institut fuer Mikrowellentechnik und Photonik, TU Darmstadt (Germany); Sydlo, Cezary; Mavric, Uros; Gerth, Christopher [DESY, Hamburg (Germany)

    2013-07-01

    For obtaining ultra short electron bunches at the Free Electron Laser at DESY (FLASH) the beam is compressed in magnetic chicanes. During the compression process the precise knowledge of the energy of the bunches is essential for the longitudinal dynamics control. The measurement of the beam position in the chicane allows for non-destructive measurements of the energy. For that purpose, two stripline pick-ups perpendicular to the beam direction are installed in the chicane at FLASH as a part of the Beam Position Monitor. The recent upgrade in the electronics as well as the increased aperture and length of the beam pipe (for the European XFEL) requires the design of new pick-ups which will fulfill the new demands. Namely, the pick-ups should have maximum signal at 3 GHz with minimum reflections. In this talk, we will present the design of planar transmission line pick-ups for FLASH and XFEL. The planar design of the pick-ups can provide for a proper impedance matching to the subsequent electronics as well as sufficient mechanical stability along the aperture when using alumina substrate. A prototype of the pick-ups was build and installed in a non-hermetic body. The measured S parameters are compared to the simulation.

  9. Company Development Through the Employees

    DEFF Research Database (Denmark)

    Møller, Niels; Hvenegaard, Hans; Limborg, Hans Jørgen

    2003-01-01

    Human Deveoplment and Working Life - Work for Welfare explores whether the development of human resources at company level can improve individuals' quality of life, companies' possibilities of development, and welfare and democracy in society. Chapter four documents the the proces and results...

  10. INNOVATION IN BRAZILIAN SMALL COMPANIES

    National Research Council Canada - National Science Library

    Rodrigues, Tonny Kerley de Alencar; Lira, Átila De Melo; Naas, Irenilza De Alencar

    2015-01-01

    .... And the data confirms that small Brazilian companies generally have difficulties to sell their innovations. Keywords: innovation, small enterprises, patents. 1. INTRODUCTION Companies worldwide are looking to technological innovation as feasible for your market expansion (BURNS; STALKER, 1961; NELSON, 1993) alternative. In Brazil, the change an...

  11. Gamification in a Consulting Company

    NARCIS (Netherlands)

    Blaauw, Frank; Bazylevska, L.; Aiello, M.

    2014-01-01

    Gamification refers to the use of game-design elements in a non-gaming context. The consulting company Capgemini has set up a rudimentary Gamification platform to help motivating the people to do extra work for the company in their spare time. In order to re- ward people for this effort, they can re

  12. Gamification in a Consulting Company

    NARCIS (Netherlands)

    Blaauw, Frank; Bazylevska, L.; Aiello, M.

    2014-01-01

    Gamification refers to the use of game-design elements in a non-gaming context. The consulting company Capgemini has set up a rudimentary Gamification platform to help motivating the people to do extra work for the company in their spare time. In order to re- ward people for this effort, they can re

  13. College Companies and Commercial Activities.

    Science.gov (United States)

    Further Education Unit, London (England).

    A feasibility study determined the number and scope of existing college companies set up by permission of the Commercial Activities in Further Education Act in Great Britain. A sample of six colleges was studied; managing directors of the six companies took part in semistructured interviews to explore some issues in greater depth. The advantages…

  14. Company Development Through the Employees

    DEFF Research Database (Denmark)

    Møller, Niels; Hvenegaard, Hans; Limborg, Hans Jørgen

    2003-01-01

    Human Deveoplment and Working Life - Work for Welfare explores whether the development of human resources at company level can improve individuals' quality of life, companies' possibilities of development, and welfare and democracy in society. Chapter four documents the the proces and results of ...... of changes at the workplace level....

  15. Responsibilities of Companies towards Employees

    Directory of Open Access Journals (Sweden)

    Monray Marsellus Botha

    2015-07-01

    Full Text Available Central to company law is the promotion of corporate governance. An important question in company law still today is in whose interest the company should be managed. Corporate governance needs to address the entire span of responsibilities to stakeholders of the company such as customers, employees, shareholders, suppliers and the community at large. The promotion of human rights in the application of company law must also take place. This is extremely important given the significant role of enterprises within the social and economic life of the nation. The interests of various stakeholder groups in the context of the corporation as a "social institution" should be enhanced and protected. Because corporations are part of society and the community, like all of us, it is required of them to be socially responsible and have greater accountability to all stakeholders of the company. Although directors must act in the best interests of shareholders collectively they must also consider the interests of other stakeholders. Sustainable relationships with all the relevant stakeholders are thus important. The advancement of social justice is thus important to corporations in that they should take note of the Constitution, labour legislation and company law legislation when social justice issues are dealt with. Employees have become very important stakeholders of companies and their needs should be taken into account in the bigger corporate governance and social responsibility framework.

  16. A strategy for company improvement.

    Science.gov (United States)

    Howley, L

    2000-03-01

    Strategies based on the kaizen methodology are designed to continuously improve company performance without the need for large capital investments. This article looks at how one company used simple kaizen principles to its advantage, achieving 67% increase in productivity and 10% reduction in the standard cost of product.

  17. 78 FR 43197 - Duke Energy Florida, Inc.; Florida Power & Light Company; Tampa Electric Company; Orlando...

    Science.gov (United States)

    2013-07-19

    ... Company; Orlando Utilities Commission; Notice of Compliance Filings Take notice that on July 10, 2013, Duke Energy Florida, Inc., Florida Power & Light Company, Tampa Electric Company, and Orlando...

  18. Jordanian pharmaceutical companies: are their marketing efforts paying off?

    Science.gov (United States)

    Al-Shaikh, Mustafa S; Torres, Ivonne M; Zuniga, Miguel A; Ghunaim, Ayman

    2011-04-01

    The pharmaceuticals industry is one of the main industries in Jordan. Jordanian pharmaceuticals rank third in the export industry of this country. This study aims to examine the strengths that Jordanian pharmaceutical companies have, which, in turn, form their competitiveness base. In addition, this study aims to identify their weaknesses and the effects of marketing their products in the local market. What is the relationship between Jordanian pharmaceutical product quality, price and value, and the competitiveness of pharmaceutical companies in the local market? Our study aims to answer this and other questions. Our results and practical implications are discussed.

  19. Principles of European Company Law

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2010-01-01

    The article focuses on how much we have in common in Europe within company law and its development, and on the principles which are the determining factors for the activities of European companies. The article shows that what we have in common greatly outweighs what divides us, and this is presen......The article focuses on how much we have in common in Europe within company law and its development, and on the principles which are the determining factors for the activities of European companies. The article shows that what we have in common greatly outweighs what divides us......, and this is presented in the article as the provisional capstone of 400 years of joint European development of company law....

  20. In Good Company

    DEFF Research Database (Denmark)

    Tartari, Valentina; Perkmann, Markus; Salter, Ammon

    2014-01-01

    Previous research on academic entrepreneurship and engagement with industry has found that the behaviour of academics is influenced by their local social context. However, we know little about the mechanisms that produce this effect. We argue that academic scientists’ industry engagement is influ...

  1. RESEARCHES REGARDING THE ONLINE PRESENCE OF THE BIHOR COUNTY COMPANIES

    Directory of Open Access Journals (Sweden)

    Mares Marius Daniel

    2012-07-01

    Full Text Available In this paper is presented a survey of companies’ websites in Bihor county. The study aims at local companies whose scope of activity allows them to interact with the end-users – individuals and whose presence in the virtual environment is ensured by websites. Companies that own a website use it for different purposes: to communicate to the users information about the company, to promote its products and services offered, to offer potential clients the opportunity to purchase these products online, to interact with their clients. The website of a company ensure its constant presence and can be used as an instrument in the marketing strategy, as a meaning of identity development or growth of the brand exposure, as a support for relationships with potential buyers or as a way of achieving market research. But for the website to fulfill the purpose for which it was made it must give the needed importance to certain aspects. Research carried out reveals an intensified concern of the companies for creating their own websites, for communicating with potential clients from the virtual environment, but they do not give importance to issues related to updating the information, structure, appearance, purpose sites. Most companies use the website mainly for information. They give little importance to promotion, yet not realizing the benefits they might have. Less than one third of the websites analyzed offers the possibility of online orders.

  2. 12 CFR 583.6 - Company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Company. 583.6 Section 583.6 Banks and Banking... AND LOAN HOLDING COMPANIES § 583.6 Company. The term company means any corporation, partnership, trust, joint-stock company, or similar organization, but does not include: (a) The Federal Deposit...

  3. Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-V.

    Science.gov (United States)

    Stein, Dan J; Grant, Jon E; Franklin, Martin E; Keuthen, Nancy; Lochner, Christine; Singer, Harvey S; Woods, Douglas W

    2010-06-01

    In DSM-IV-TR, trichotillomania (TTM) is classified as an impulse control disorder (not classified elsewhere), skin picking lacks its own diagnostic category (but might be diagnosed as an impulse control disorder not otherwise specified), and stereotypic movement disorder is classified as a disorder usually first diagnosed in infancy, childhood, or adolescence. ICD-10 classifies TTM as a habit and impulse disorder, and includes stereotyped movement disorders in a section on other behavioral and emotional disorders with onset usually occurring in childhood and adolescence. This article provides a focused review of nosological issues relevant to DSM-V, given recent empirical findings. This review presents a number of options and preliminary recommendations to be considered for DSM-V: (1) Although TTM fits optimally into a category of body-focused repetitive behavioral disorders, in a nosology comprised of relatively few major categories it fits best within a category of motoric obsessive-compulsive spectrum disorders, (2) available evidence does not support continuing to include (current) diagnostic criteria B and C for TTM in DSM-V, (3) the text for TTM should be updated to describe subtypes and forms of hair pulling, (4) there are persuasive reasons for referring to TTM as "hair pulling disorder (trichotillomania)," (5) diagnostic criteria for skin picking disorder should be included in DSM-V or in DSM-Vs Appendix of Criteria Sets Provided for Further Study, and (6) the diagnostic criteria for stereotypic movement disorder should be clarified and simplified, bringing them in line with those for hair pulling and skin picking disorder.

  4. Understanding Human Hand Gestures for Learning Robot Pick-and-Place Tasks

    Directory of Open Access Journals (Sweden)

    Hsien-I Lin

    2015-05-01

    Full Text Available Programming robots by human demonstration is an intuitive approach, especially by gestures. Because robot pick-and-place tasks are widely used in industrial factories, this paper proposes a framework to learn robot pick-and-place tasks by understanding human hand gestures. The proposed framework is composed of the module of gesture recognition and the module of robot behaviour control. For the module of gesture recognition, transport empty (TE, transport loaded (TL, grasp (G, and release (RL from Gilbreth's therbligs are the hand gestures to be recognized. A convolution neural network (CNN is adopted to recognize these gestures from a camera image. To achieve the robust performance, the skin model by a Gaussian mixture model (GMM is used to filter out non-skin colours of an image, and the calibration of position and orientation is applied to obtain the neutral hand pose before the training and testing of the CNN. For the module of robot behaviour control, the corresponding robot motion primitives to TE, TL, G, and RL, respectively, are implemented in the robot. To manage the primitives in the robot system, a behaviour-based programming platform based on the Extensible Agent Behavior Specification Language (XABSL is adopted. Because the XABSL provides the flexibility and re-usability of the robot primitives, the hand motion sequence from the module of gesture recognition can be easily used in the XABSL programming platform to implement the robot pick-and-place tasks. The experimental evaluation of seven subjects performing seven hand gestures showed that the average recognition rate was 95.96%. Moreover, by the XABSL programming platform, the experiment showed the cube-stacking task was easily programmed by human demonstration.

  5. 78 FR 35360 - Surety Companies Acceptable on Federal Bonds: Terminations-American Economy Insurance Company...

    Science.gov (United States)

    2013-06-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Fiscal Service Surety Companies Acceptable on Federal Bonds: Terminations-- American Economy Insurance Company (NAIC 19690); American States Insurance Company (NAIC 19704); General Insurance Company of America...

  6. STRATEGIC COMMUNICATION IN MULTINATIONAL COMPANIES

    Directory of Open Access Journals (Sweden)

    Alexandrina Cristina VASILE

    2014-11-01

    Full Text Available The article intends to show how multinational companies gain market share and visibility by using the appropriate strategic communication. The study evaluate the base framework, analysis, tools, data sources, sets of improvement plans and results that some multinational companies obtain by using strategic communication. The analysed companies are American based mainly communicative corporations and it will be underlined the importance of communication in the current economic environment. The results will show how important strategic communication is along the information used and the strategic management in targeting the position in the market.

  7. MANAGER AND LEADERSHIP OF COMPANY

    OpenAIRE

    Rožič, Marko

    2014-01-01

    In my diploma work I presented a manager as the leading person in a company, who has the task of realizing the goals set and is along with employees creating a better tomorrow. Without a good manager, who knows what to do and how to reach good results, an company cannot be successful and cannot develop. I wanted to present a manager, who has the power to help create a story of success in an company. However without the support and cooperation of colleagues that goal cannot be fulfilled. There...

  8. MOC encourages private oil companies

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The Ministry of Commerce issued a guideline in late June, encouraging private oil companies to take part in refined oil's processing, transportation and retail. The government will support competitive and large companies to integrate into asset-based oil groups and technology service-based oil companies, according to the guideline. Private business will be encouraged to obtain stable access to refined oil resources, technology and management service. China's refined oil market is largely controlled by three State-owned heavyweights: PetroChina, the largest oil producer in Asia; Sinopec,

  9. HOW COFFEE COMPANIES CAN STAY COMPETITIVE

    Directory of Open Access Journals (Sweden)

    RALUCA DANIELA RIZEA

    2014-04-01

    Full Text Available The coffee shop industry in the U.S. includes 20,000 stores with combined annual revenue of about $11 billion. Major companies include Starbucks, Dunkin’ Donuts, Caribou, Coffee Bean and Tea Leaf, and Diedrich (Gloria Jean’s. The industry is highly concentrated at the top and fragmented at the bottom: the top 50 companies have over 70 percent of industry sales. Coffee is one of the world’s largest commodities. The top green coffee producing countries are Brazil, Colombia, and Vietnam. Many grower countries are small, poor developing nations that depend on coffee to sustain local economies. The U.S. is the world’s largest importer of green coffee beans and the largest consumer of coffee. The main objective of this study is to investigate the competitive strategies that U.S. coffee franchise companies adopt considering customers’ expectations and industry best practices. In order to achieve this objective, a best practice benchmarking analysis was performed taking into account the top U.S. coffee companies This analysis showed that product and service innovation are necessary in order to stay competitive in the market and attract new or to keep existing customers successfully. Many customers focus on the special atmosphere each store has and which is characterized by the location, music, interior design, seating or whether internet access is provided. Particularly for specialty coffee shops it is important not to sell only the beverage but the whole experience. Coffee shops have to establish a unique image that prevents customers from buying products from another shop or use home-brewing systems which are also on the rise in American households. In addressing the increased level of competition, every company’s focus should be on differentiating from the rest of the market in every possible business segment (products, atmosphere, location, image etc..

  10. HOW COFFEE COMPANIES CAN STAY COMPETITIVE

    Directory of Open Access Journals (Sweden)

    RALUCA DANIELA RIZEA

    2014-04-01

    Full Text Available The coffee shop industry in the U.S. includes 20,000 stores with combined annual revenue of about $11 billion. Major companies include Starbucks, Dunkin’ Donuts, Caribou, Coffee Bean and Tea Leaf, and Diedrich (Gloria Jean’s. The industry is highly concentrated at the top and fragmented at the bottom: the top 50 companies have over 70 percent of industry sales. Coffee is one of the world’s largest commodities. The top green coffee producing countries are Brazil, Colombia, and Vietnam. Many grower countries are small, poor developing nations that depend on coffee to sustain local economies. The U.S. is the world’s largest importer of green coffee beans and the largest consumer of coffee. The main objective of this study is to investigate the competitive strategies that U.S. coffee franchise companies adopt considering customers’ expectations and industry best practices. In order to achieve this objective, a best practice benchmarking analysis was performed taking into account the top U.S. coffee companies This analysis showed that product and service innovation are necessary in order to stay competitive in the market and attract new or to keep existing customers successfully. Many customers focus on the special atmosphere each store has and which is characterized by the location, music, interior design, seating or whether internet access is provided. Particularly for specialty coffee shops it is important not to sell only the beverage but the whole experience. Coffee shops have to establish a unique image that prevents customers from buying products from another shop or use home-brewing systems which are also on the rise in American households. In addressing the increased level of competition, every company’s focus should be on differentiating from the rest of the market in every possible business segment (products, atmosphere, location, image etc..

  11. A digital algorithm for spectral deconvolution with noise filtering and peak picking: NOFIPP-DECON

    Science.gov (United States)

    Edwards, T. R.; Settle, G. L.; Knight, R. D.

    1975-01-01

    Noise-filtering, peak-picking deconvolution software incorporates multiple convoluted convolute integers and multiparameter optimization pattern search. The two theories are described and three aspects of the software package are discussed in detail. Noise-filtering deconvolution was applied to a number of experimental cases ranging from noisy, nondispersive X-ray analyzer data to very noisy photoelectric polarimeter data. Comparisons were made with published infrared data, and a man-machine interactive language has evolved for assisting in very difficult cases. A modified version of the program is being used for routine preprocessing of mass spectral and gas chromatographic data.

  12. Detection of Avian bornavirus 5 RNA in Eclectus roratus with feather picking disorder.

    Science.gov (United States)

    Horie, Masayuki; Ueda, Kengo; Ueda, Akiko; Honda, Tomoyuki; Tomonaga, Keizo

    2012-05-01

    Avian bornavirus (ABV) was discovered recently in parrots with proventricular dilatation disease (PDD), a fatal neurological disease. Although ABV has been shown to be a causative agent of PDD, its virological characteristics are largely unknown. Here we report the detection of ABV genotype 5 RNA in an Eclectus roratus with feather picking disorder (FPD). Interestingly, although the bird was persistently infected with ABV5 for at least 8 months, it had no clinical signs of PDD. Although it remains unclear whether ABV5 is associated with FPD, these findings raise the importance of epidemiological studies of birds with diseases other than PDD. © 2012 The Societies and Blackwell Publishing Asia Pty Ltd.

  13. Stellar wind interaction and pick-up ion escape of the Kepler-11 "super-Earths"

    Science.gov (United States)

    Kislyakova, Kristina; Johnstone, Colin; Odert, Petra; Erkaev, Nikolai; Lammer, Helmut; Lüftinger, Theresa; Holmstöm, Mats; Khodachenko, Maxim; Güdel, Manuel

    2014-05-01

    We present the results of modeling of the interactions between stellar wind and the extended hydrogen-dominated upper atmospheres of planets and estimate the resulting escape of planetary pick-up ions from the 5 «super-Earths» in the compact Kepler-11 system. We compare the escape rates with the efficiency of the thermal escape of neutral hydrogen atoms. Assuming the stellar wind of Kepler-11 is similar to the solar wind, we used a polytropic 1D hydrodynamic wind model to estimate the wind properties at the planetary orbits. We applied a Direct Simulation Monte Carlo Model to model the hydrogen coronae and the stellar wind plasma interaction around Kepler-11b-f planets within a realistic expected heating efficiency range of 15-40%. The same model was used to estimate the ion pick-up escape from the XUV heated and hydrodynamically extended upper atmospheres of Kepler-11b-f. Modeling clarifies the influence of possible magnetic moments on escape processes and allows to estimate the charge exchange and photoionization production rates of planetary ions as well as the loss rates of pick-up H+ ions for all five planets. This study presents also the comparison of the results between the five 'super-Earths' and in a more general sense also with the thermal escape rates of the neutral planetary hydrogen atoms. Our results show that for all Kepler-11b-f exoplanets, a huge neutral hydrogen corona is formed around the planet. The non-symmetric form of the corona changes from planet to planet and is defined mostly by radiation pressure, charge-exchange and gravitational effects. According to our estimates, nonthermal escape rates of pick-up ionized hydrogen atoms for Kepler-11 «super-Earths» vary between ~ 6.4 × 1030 s-1 and ~ 4.1 × 1031 s-1 depending on the planet's orbital location and assumed heating efficiency. These values correspond to non-thermal mass loss rates of ~ 1.07 × 107 g·s-1 and ~ 6.8 × 107 g·s-1 respectively, which is a few percent of the thermal

  14. Bin-Picking based on Harmonic Shape Contexts and Graph-Based Matching

    DEFF Research Database (Denmark)

    Moeslund, Thomas B.; Kirkegaard, Jakob

    2006-01-01

    In this work we address the general bin-picking problem where 3D data is available. We apply Harmonic Shape Contexts (HSC) features since these are invariant to translation, scale, and 3D rotation. Each object is divided into a number of sub-models each represented by a number of HSC features....... These are compared with HSC features extracted in the current data using a graph-based scheme. Results show that the approach is somewhat sensitive to noise, but works in presence of occlusion....

  15. Positronium in Solids: Computer Simulation of Pick-Off and Self-Annihilation

    Energy Technology Data Exchange (ETDEWEB)

    Bug, A; Muluneh, M; Waldman, J; Sterne, P

    2003-08-01

    Positronium (Ps) is simulated using Path Integral Monte Carlo (PIMC). This method can reproduce the results of previous simple theories in which a single quantum particle is used to represent Ps within an idealized pore. In addition, the calculations treat the e{sup -} and e{sup +} of Ps exactly and realistically model interactions with solid atoms, thereby correcting and extending the simpler theory. They study the pick-off lifetime of o-Ps and the internal contact density, {kappa}, which controls the self-annihilation behavior, for Ps in model voids (spherical pores), defects in a solid (argon), and microporous solids (zeolites).

  16. Modelado y análisis de mecanismos para funciones de Pick & Place

    OpenAIRE

    Gutiérrez Castro, Daniel

    2011-01-01

    Este proyecto trata de analizar el comportamiento de una serie de mecanismos que pretenden ser utilizados en la práctica como mecanismo de acción en brazos robóticos. Dichos brazos robóticos se diseñarán con vista a realizar funciones de pick & place en líneas de fabricación. La diferencia de estos mecanismos con los que existen en la actualidad es la simplicidad en cuanto al control de la actuación. En el presente estudio, la actuación es llevada a cabo por un sólo motor. C...

  17. Rock Breaking Performance of a Pick Assisted by High-pressure Water Jet under Different Configuration Modes

    Institute of Scientific and Technical Information of China (English)

    LIU Songyong; LIU Xiaohui; CHEN Junfeng; LIN Mingxing

    2015-01-01

    In the process of rock breaking, the conical pick bears great cutting force and wear, as a result, high-pressure water jet technology is used to assist with cutting. However, the effect of the water jet position has not been studied for rock breaking using a pick. Therefore, the models of rock breaking with different configuration modes of the water jet are established based on SPH combined with FEM. The effect of the water jet pressure, distance between the jet and the pick bit, and cutting depth on the rock breaking performance as well as a comparison of the tension and compression stress are studied via simulation; the simulation results are verified by experiments. The numerical and experimental results indicate that the decrease in the rates of the pick force obviously increases from 25 MPa to 40 MPa, but slowly after 40 MPa, and the optimal distance between the jet and the pick bit is 2 mm under the JFP and JSP modes. The JCP mode is proved the best, followed by the modes of JRP and JFP, and the worst mode is JSP. The decrease in the rates of the pick force of the JCP, JRP, JFP, and JSP modes are up to 30.96%, 28.96%, 33.46%, 28.17%, and 25.42%, respectively, in experiment. Moreover, the JSP mode can be regarded as a special JFP model when the distance between the pick-tip and the jet impact point is 0 mm. This paper has a dominant capability in introducing new numerical and experimental method for the study of rock breaking assisted by water jet and electing the best water jet position from four different configuration modes.

  18. 76 FR 9348 - Southern California Edison Company, Pacific Gas and Electric Company, San Diego Gas & Electric...

    Science.gov (United States)

    2011-02-17

    ... Diego Gas & Electric Company; Notice of Petition Take notice that on January 31, 2011, pursuant to... Edison Company (SCE), Pacific Gas and Electric Company (PG&E), and San Diego Gas & Electric Company (SDG..., Joint Petition of Pacific Gas and Electric Company, Southern California Edison Company, and San Diego...

  19. Human resource policy and Danish multinational companies

    DEFF Research Database (Denmark)

    Fleming, Daniel; Søborg, Henrik

    A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore.......A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore....

  20. LIQUIDATION AND WINDING UP OF COMPANIES

    National Research Council Canada - National Science Library

    Norman M Mzizi

    2014-01-01

    ... or not; accordingly it is not a bar to an application to wind up a company in terms of the Companies Act 1973 on the grounds that it is commercially insolvent. It will, however, always be a factor in deciding whether a company is unable to pay its debts. Thus a commercially solvent company may be wound up in terms of the Companies Act 71 of 2008 only; a solvent company cannot be wound up in terms of the old Act.

  1. Human resource policy and Danish multinational companies

    DEFF Research Database (Denmark)

    Fleming, Daniel; Søborg, Henrik

    A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore.......A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore....

  2. LEADERSHIP DEVELOPMENTS IN SLOVENIAN COMPANIES

    Directory of Open Access Journals (Sweden)

    Andrej Kohont

    2016-04-01

    Full Text Available In this paper we study the relationship between the company and the leaders. We are interested what is characteristic of leadership in the best Slovenian companies. We used standardised employee questionnaire and data gathered in the Golden thread project. We observe the situation in these companies in the period between 2007 and 2014 to find out if there are any significant changes in leadership developments. Special attention in leadership observation is devoted to 1. The fundamental relationship between the company and the leaders, 2. The role and quality of leaders work, 3. Organizational culture, climate and relationships, 4. Entrepreneurship and innovation, 5. The quality of the working environment, 6. The personal growth and development and 7. Emotional commitment. The analysis represents an insight into current leadership situation and shows that the recent developments were heavily marked by the economic crisis, especially in 2009.

  3. International Companies in Fragile States

    DEFF Research Database (Denmark)

    Patey, Luke; Kragelund, Peter

    Denmark must not fail to promote corporate social responsibility in fragile states. International companies remain active in these environments, and often worsen rather than alleviate poor governance. Financial transparency and human rights initiatives offer the first step in ensuring...

  4. WHEN PRIVATE COMPANIES BECOME 'REGULATED'

    National Research Council Canada - National Science Library

    Mark Silberman

    2013-01-01

    ... in additional administrative requirements. There is confusion as many practitioners don't know about these requirements and in the case of numerous smaller companies, there is probably no compliance...

  5. BUSINESS INTELLIGENCE FOR INSURANCE COMPANIES

    Directory of Open Access Journals (Sweden)

    A. Ignatiuk

    2016-06-01

    Full Text Available The current state and future trends for the world and domestic insurance markets are analyzed. The description of business intelligence methodology, tools and their practical implication for insurance companies are provided.

  6. East India Company Logbooks - Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection consists of images of 1,235 ship logbooks created during British East India Company voyages. Period of record 1786-1834, peaking in 1804. The...

  7. Marketing audit in selected company

    OpenAIRE

    ŠACHTA, Martin

    2014-01-01

    This thesis addresses the implementation of marketing audit in selected companies. For the analysis of the selected engineering company ENGEL Strojirenska ltd. based in the South Bohemian Kaplice. The thesis is divided into an introduction and objectives, literature review, characteristics, implementing marketing audit itself, solution design changes, conclusion and list of references. The literature review is characterized by marketing, micro and macro environments, PEST analysis, Porter's f...

  8. COMPANIES WITH MARKET POSITIONING BRANDS

    OpenAIRE

    Ruxandra Radoviciu; Filimon Stremtan

    2009-01-01

    Positioning a company on the market by the usage of brands is defined as the act ofdesigning the supply and its image on the market, so as to occupy a distinct place in the minds of theirtarget audience. The role of positioning in developing marketing strategy to differentiate products andservices involves the selection of attributes that are considered important for consumers. In order togain a strong position on the market the companies must perform a market analysis, an internalanalysis an...

  9. Building a better biotech company.

    Science.gov (United States)

    Turner, L

    1999-02-01

    Invitrogen is a good case study for how to become successful in the rapidly changing field of biotechnology by observing basic business principles. It also shows that even the most successful companies make mistakes. The exciting opportunities that present themselves to high-technology companies in fast-growth fields can divert attention away from the most basic business tenets of quality, profitability, and market responsiveness. CEOs in the biotechnology sector would be well served to review their Business 101 lessons.

  10. Benchmarking in Mobarakeh Steel Company

    Directory of Open Access Journals (Sweden)

    Sasan Ghasemi

    2008-05-01

    Full Text Available Benchmarking is considered as one of the most effective ways of improving performance incompanies. Although benchmarking in business organizations is a relatively new concept and practice, ithas rapidly gained acceptance worldwide. This paper introduces the benchmarking project conducted in Esfahan’s Mobarakeh Steel Company, as the first systematic benchmarking project conducted in Iran. It aimsto share the process deployed for the benchmarking project in this company and illustrate how the projectsystematic implementation led to succes.

  11. Corporate Mobility and Company Law

    OpenAIRE

    Ferran, Eilís

    2016-01-01

    Globalisation has given commercial parties more freedom to choose the company law system that best suits their private needs. The growing range of techniques to facilitate choice between systems of company law reshapes the mandatory/enabling debate in countries where corporate mobility is a relatively new business phenomenon and where the past focus has mostly been on degrees of flexibility within domestic law. This article examines relocations, both out of and into the UK, as a source of lea...

  12. CSR Important to Oil Companies

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Corporations are human endeavors, and all human endeavors should benefit our society and reflect our morals. They should provide more than just investor return. The nature of oil industry demands that oil companies be socially responsible in addition to operating in an ethical and environmentally friendly manner. At a time of rising energy prices and global concern over our energy future, however, oil companies should give even greater emphasis to this part of their approach to corporate social responsibility(CSR).

  13. Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding

    DEFF Research Database (Denmark)

    Ammendrup-Johnsen, Ina; Thorsen, Thor Seneca; Gether, Ulrik

    2012-01-01

    PICK1 (protein interacting with C kinase 1) contains an N-terminal protein binding PDZ domain and a C-terminal lipid binding BAR domain. PICK1 plays a key role in several physiological processes, including synaptic plasticity. However, little is known about the cellular mechanisms governing...... the activity of PICK1 itself. Here we show that PICK1 is a substrate in vitro both for PKCα (protein kinase Cα), as previously shown, and for CaMKIIα (Ca(2+)-calmodulin-dependent protein kinase IIα). By mutation of predicted phosphorylation sites, we identify Ser77 in the PDZ domain as a major phosphorylation...... for optimal phosphorylation. Binding of PKCα to the PICK1 PDZ domain was not required for phosphorylation, but a PDZ domain peptide ligand reduced the overall level of phosphorylation ~30%. The phosphomimic S77D reduced the extent of cytosolic clustering of eYFP-PICK1 in COS7 cells and thereby conceivably its...

  14. Trade Companies and their Classification

    Directory of Open Access Journals (Sweden)

    P. Tărchilă

    2013-12-01

    Full Text Available The Romanian legislation does not define anyhow the concept of companies. It was the merit of the doctrine, which attempted such a definition, starting usually from the provisions of the Civil Code, which in art. 1491 defines the civil society, for the purpose of the memorandum of the association1. For that matter, also in the specialized foreign doctrine (ex. the French doctrine companies are defined based on similar concepts, but standardized by the Civil Code. The two meanings that the company has to be regarded through, also explain the very specific legal matter, a matter of concepts resulting from understanding the concept of memorandum of association and the company-institution. Thus, the contractual conception, imposed by the development of the contract theory in the last century, explains the existence of the companies starting from the validity conditions imposed to any contract and from the contractual techniques that establish the relationships formed within the society (for example, the company management is based on a mandate contract under which the executive operates.

  15. IT Project Management in Very Small Software Companies

    DEFF Research Database (Denmark)

    Shakir, Shahid Nadeem; Nørbjerg, Jacob

    2013-01-01

    In developing countries very small software companies (VSSCs) with only 1-10 employees play an important role both in the local economy and as providers of software and services to customers in other parts of the world. Understanding and improving their IT project management (ITPM) practices...

  16. Spotting Fruit versus Picking Fruit as the Selective Advantage of Human Colour Vision

    Directory of Open Access Journals (Sweden)

    Aline Bompas

    2013-04-01

    Full Text Available The spatiochromatic properties of the red–green dimension of human colour vision appear to be optimized for picking fruit in leaves at about arms' reach. However, other evidence suggests that the task of spotting fruit from a distance might be more important. This discrepancy may arise because the task a system (e.g. human trichromacy is best at is not necessarily the same task where the largest advantage occurs over the evolutionary alternatives (dichromacy or anomalous trichromacy. We tested human dichromats, anomalous trichromats and “normal” trichromats in a naturalistic visual search task in which they had to find fruit pieces in a bush at 1, 4, 8 or 12 m viewing distance. We found that the largest advantage (in terms of either performance ratio or performance difference of normal trichromacy over both types of colour deficiency was for the largest viewing distance. We infer that in the evolution of human colour vision, spotting fruit from a distance was a more important selective advantage than picking fruit at arms' reach.

  17. White matter abnormalities in skin picking disorder: a diffusion tensor imaging study.

    Science.gov (United States)

    Grant, Jon E; Odlaug, Brian L; Hampshire, Adam; Schreiber, Liana R N; Chamberlain, Samuel R

    2013-04-01

    Skin picking disorder (SPD) is characterized by the repetitive and compulsive picking of skin, resulting in tissue damage. Neurocognitive findings in SPD implicate difficulty with response inhibition (suppression of pre-potent motor responses). This function is dependent on the integrity of the right frontal gyrus and the anterior cingulate cortices, and white-matter tracts connecting such neural nodes. It was hypothesized that SPD would be associated with reduced fractional anisotropy in regions implicated in top-down response suppression, particularly white-matter tracts in proximity of the bilateral anterior cingulate and right frontal (especially orbitofrontal and inferior frontal) cortices. 13-subjects meeting proposed SPD criteria for DSM-5 free from other current psychiatric comorbidities, and 12 healthy comparison subjects underwent MRI with a 3-T system. Between-group comparisons of imaging data underwent voxelwise analysis with permutation modeling and cluster correction. Fractional anisotropy (measured using diffusion tensor imaging) was the primary outcome measure. Subjects with SPD exhibited significantly reduced fractional anisotropy in tracts distributed bilaterally, which included the anterior cingulate cortices. Fractional anisotropy did not correlate significantly with SPD disease severity, or depressive or anxiety scores. These findings implicate disorganization of white-matter tracts involved in motor generation and suppression in the pathophysiology of SPD, findings remarkably similar to those previously reported in trichotillomania. This study adds considerable support to the notion that-in addition to the phenomenological and comorbid overlap between SPD and trichotillomania-these disorders likely share overlapping neurobiology.

  18. A theoretical model for predicting the Peak Cutting Force of conical picks

    Directory of Open Access Journals (Sweden)

    Gao Kuidong

    2014-01-01

    Full Text Available In order to predict the PCF (Peak Cutting Force of conical pick in rock cutting process, a theoretical model is established based on elastic fracture mechanics theory. The vertical fracture model of rock cutting fragment is also established based on the maximum tensile criterion. The relation between vertical fracture angle and associated parameters (cutting parameter  and ratio B of rock compressive strength to tensile strength is obtained by numerical analysis method and polynomial regression method, and the correctness of rock vertical fracture model is verified through experiments. Linear regression coefficient between the PCF of prediction and experiments is 0.81, and significance level less than 0.05 shows that the model for predicting the PCF is correct and reliable. A comparative analysis between the PCF obtained from this model and Evans model reveals that the result of this prediction model is more reliable and accurate. The results of this work could provide some guidance for studying the rock cutting theory of conical pick and designing the cutting mechanism.

  19. Pick and Alzheimer diseases: a rare comorbidity presenting as corticobasal syndrome.

    Science.gov (United States)

    Rusina, Robert; Pazdera, Ladislav; Kulišťák, Petr; Vyšata, Oldřich; Matěj, Radoslav

    2013-12-01

    We describe a patient with corticobasal syndrome in whom neuropathological examination on autopsy revealed Pick and Alzheimer diseases in comorbidity. Corticobasal degeneration is a tauopathy usually associated with asymmetric parkinsonism, parietal lobe involvement, and cognitive impairment. Corticobasal syndrome is the clinical presentation of corticobasal degeneration without neuropathological confirmation. A 66-year-old right-handed man slowly developed speech difficulties, right-hand clumsiness, and forgetfulness. His speech apraxia progressed to mutism with preserved comprehension, and his clumsiness progressed to severe apraxia involving both hands. He developed behavioral changes and severe amnesia. All of these features were consistent with corticobasal syndrome. His loss of episodic, verbal, and visuospatial memory suggested Alzheimer disease; however, beyond his frontotemporal neuropsychological profile, he had few symptoms characteristic of frontal lobe dementia. Magnetic resonance imaging scans showed worsening temporal, frontal, and parietal atrophy, predominant in the left hemisphere. Neuropathological examination at autopsy revealed abundant neuritic plaques and neurofibrillary tangles consistent with fully developed Alzheimer disease, as well as numerous intraneuronal Pick bodies in the frontotemporal lobes. Our findings confirm the importance of clinical and neuropathological correlations in patients with atypical neurodegenerative dementias.

  20. C1q, the classical complement pathway protein binds Hirano bodies in Pick's disease.

    Science.gov (United States)

    Singhrao, Sim K

    2013-06-01

    Haematoxylin/Eosin staining was performed to screen for Hirano bodies from the temporal lobe including the hippocampus in 10 Pick's disease cases containing Pick bodies. Although the inclusions were confirmed in 9 out of 10 cases, only 4 out of 10 were particularly enriched with the eosinophilic bodies. These were subjected to immunostaining with anticomplement antibodies and astrocyte marker antiglial fibrillary acidic protein antibody and the HLA class II CR3/43 antibody to visualize microglia. An intraneuronal Hirano body was observed in one case that otherwise contained mainly the extracellular inclusions. In all cases, the extracellular Hirano bodies were seen lying adjacent to soma of neurons within CA1 region of the hippocampus. The extracellular Hirano bodies stained intensely with C1q, the first component of the classical pathway of activation but remained unreactive against antibodies to C4 and the C3 activation products (C3b and iC3b) and the alternative complement pathway component factor B. Hirano bodies also remained negative with the antiglial fibrillary acidic protein for astrocytes and HLA class II antibody CR3/43 for microglia. The results demonstrate that Hirano bodies have strong immunoreactivity to C1q; however, whether other complement components are associated with these inclusions remains to be further investigated.

  1. Automated Trajectory Planner of Industrial Robot for Pick-and-Place Task

    Directory of Open Access Journals (Sweden)

    S. Saravana Perumaal

    2013-02-01

    Full Text Available Industrial robots, due to their great speed, precision and cost-effectiveness in repetitive tasks, now tend to be used in place of human workers in automated manufacturing systems. In particular, they perform the pick-and-place operation, a non-value-added activity which at the same time cannot be eliminated. Hence, minimum time is an important consideration for economic reasons in the trajectory planning system of the manipulator. The trajectory should also be smooth to handle parts precisely in applications such as semiconductor manufacturing, processing and handling of chemicals and medicines, and fluid and aerosol deposition. In this paper, an automated trajectory planner is proposed to determine a smooth, minimum-time and collision-free trajectory for the pick-and-place operations of a 6-DOF robotic manipulator in the presence of an obstacle. Subsequently, it also proposes an algorithm for the jerk-bounded Synchronized Trigonometric S-curve Trajectory (STST and the ‘forbidden-sphere’ technique to avoid the obstacle. The proposed planner is demonstrated with suitable examples and comparisons. The experiments show that the proposed planner is capable of providing a smoother trajectory than the cubic spline based trajectory.

  2. A robust solution for hesitate phenomenon in pick up process of aerospace electromagnetic relay

    Institute of Scientific and Technical Information of China (English)

    Ye Xuerong; Deng Jie; Ma Yue; Zhai Guofu; Yan Jihong

    2013-01-01

    As for aerospace electromagnetic relay (AEMR) which is of small batches and having difficulty in automatic production,the uncertainty phenomenon is remarkable due to excessive manual work involved in the assembly and adjustment processes.This kind of uncertainty may increase the coil voltage difference (CVD) caused by hesitate phenomenon in the pick up process of AEMR.Taking a certain type of AEMR for example,the CVD problem in the actual producing process has been studied in this paper.The primary cause of this issue,two-steps of armature motion (namely hesitate phenomenon) in the pick up process,has been found by analyzing the matching characteristics of electromagnetic and mechanical torques of AEMR.Through the optimization of the matching characteristics,the two-steps of armature motion problem is solved by robust design of the return reed which is a key part of AEMR.The validity of this research has been proved by the comparison of characteristics of AMER before and after the optimization.

  3. Factor Structure, Validity and Reliability of the Revised Version of Skin Picking Scale

    Directory of Open Access Journals (Sweden)

    Mehdi Rabiei

    2014-09-01

    Full Text Available Background: The purpose of this study was to examine the factor structure, validity and reliability of the Skin Picking Scale-Revised Version. Materials and Methods: In this descriptive and validation study, participants were 550 (250 male and 300 female of the University of Isfahan were selected randomly from 15000 students. In order to examine the factor structure of the SPS-R we conducted both exploratory and confirmatory factor analyses and Cronbach's alpha. Results: Convergent validity of SPS-R with YBOCS-BDD, OCI-R and DASS 21-item were r=0.45, r=0.51 and r=0.70 (p<0.001. Exploratory and confirmatory factor analyses revealed two factors, one assessing impairment and the other symptom severity (4 items each. These factors could determine 58.1% of the variance. The Cronbach's alpha for the two factors were above 0.88. Also, results were shown to possess good psychometric properties, as well as discriminant validity and classification accuracy, in both clinical and community populations. Conclusion: It can be concluded that this instrument is a useful measure for assess skin-picking disorder symptoms in clinical assessment.

  4. Stellar wind interaction and pick-up ion escape of the Kepler-11 "super-Earths"

    CERN Document Server

    Kislyakova, K G; Odert, P; Erkaev, N V; Lammer, H; üftinger, T L; Holmström, M; Khodachenko, M L; üdel, M G

    2013-01-01

    We study the interactions between stellar wind and the extended hydrogen-dominated upper atmospheres of planets and the resulting escape of planetary pick-up ions from the 5 "super-Earths" in the compact Kepler-11 system and compare the escape rates with the efficiency of the thermal escape of neutral hydrogen atoms. Assuming the stellar wind of Kepler-11 is similar to the solar wind, we use a polytropic 1D hydrodynamic wind model to estimate the wind properties at the planetary orbits. We apply a Direct Simulation Monte Carlo Model to model the hydrogen coronae and the stellar wind plasma interaction around Kepler-11b-f within a realistic expected heating efficiency range of 15-40%. The same model is used to estimate the ion pick-up escape from the XUV heated and hydrodynamically extended upper atmospheres of Kepler-11b-f. From the interaction model we study the influence of possible magnetic moments, calculate the charge exchange and photoionization production rates of planetary ions and estimate the loss r...

  5. EGCG通过 PICK1抑制可卡因小鼠的自发活动机制研究%EGC G Inhibits Cocaine Induced Locomotor Activity via PICK1

    Institute of Scientific and Technical Information of China (English)

    蔡飞; 李彩蓉; 袁鑫; 王江华; 蔡雪洲

    2013-01-01

    Objective The aim of this study was to examine the effect of EGCG on cocaine induced lo-comotor activity in mice ,and to explore its mechanism of action .Methods EGCG was pretreated before cocaine which was used by intraperitoneal injection .Locomotor activity was detected by behavioral test and the expres-sion of PICK1 protein in the nucleus accumbens ( NAc) was tested by Western blot .Results EGCG can inhibit cocaine induced locomotor activity ,and reduce the expression of PICK 1 protein in NAc.Conclusion EGCG may be important pharmocological effect to prevent cocaine induced drug abuse ,which may be related to inhibition of nucleus accumbens PICK 1 protein expression .%目的:观察EGCG对可卡因小鼠自发活动的影响,并探讨其作用机制。方法通过小鼠腹腔注射可卡因,预先给予EGCG进行干预,采用行为学检测小鼠的自发活动,采用Western blot 的方法检测小鼠伏隔核PICK1蛋白的表达。结果EGCG可抑制可卡因所致小鼠自发活动的增强,并且减少小鼠伏隔核 PICK1蛋白表达。结论EGCG可能对可卡因所致的药物成瘾有防治作用,其作用可能与抑制伏隔核PICK1蛋白表达有关。

  6. Changing local land systems

    DEFF Research Database (Denmark)

    Friis, Cecilie; Reenberg, Anette; Heinimann, Andreas

    2016-01-01

    This paper investigates the direct and cascading land system consequences of a Chinese company's land acquisition for rubber cultivation in northern Laos. Transnational land acquisitions are increasingly acknowledged as an important driver of direct land use conversion with implications for local....... Combining the conceptual lenses of land systems and livelihood approaches, this paper demonstrates how the land use system has changed substantially because of the establishment of the rubber plantation by the company, notably in the linkages between livestock rearing, upland shifting cultivation...... and lowland paddy rice cultivation. The changes go beyond the immediate competition for land caused by the rubber plantation: a penalty scheme introduced by the rubber company for damage to rubber trees caused by browsing animals has led the villagers to abandon livestock rearing, causing a cascade...

  7. Community-company relations in gold mining in Ghana.

    Science.gov (United States)

    Garvin, Theresa; McGee, Tara K; Smoyer-Tomic, Karen E; Aubynn, Emmanuel Ato

    2009-01-01

    As a result of Structural Adjustment Programme from the 1980s, many developing countries have experienced an increase in resource extraction activities by international and transnational corporations. The work reported here examines the perceived impacts of gold mining at the community level in the Wassa West District of Ghana, Africa and discusses those perceived impacts in the context of globalization processes and growing multinational corporate interest in Corporate Social Responsibility (CSR). Interview data compared community members' perceptions with those of company representatives in three communities. The results indicate that communities held companies responsible for a series of economic, social, and environmental changes. While recognizing some of the benefits brought by the mines, communities felt that the companies did not live up to their responsibility to support local development. Companies responded by denying, dismissing concerns, or shifting blame. Findings from this work show that lack of engagement and action by government agencies at all levels resulted in companies acting in a surrogate governmental capacity. In such situations, managing expectations is key to community-company relations.

  8. 77 FR 47922 - BNSF Railway Company-Trackage Rights Exemption-Northern Lines Railway, Inc.

    Science.gov (United States)

    2012-08-10

    ... Surface Transportation Board BNSF Railway Company--Trackage Rights Exemption--Northern Lines Railway, Inc. Pursuant to a written trackage rights agreement, Northern Lines Railway, Inc. (NLR), has agreed to grant restricted local trackage rights to BNSF Railway Company (BNSF) over the rail lines owned by BNSF and leased...

  9. 76 FR 31009 - BNSF Railway Company-Trackage Rights Exemption-Yellowstone Valley Railroad, Inc.

    Science.gov (United States)

    2011-05-27

    ... Surface Transportation Board BNSF Railway Company--Trackage Rights Exemption--Yellowstone Valley Railroad, Inc. Yellowstone Valley Railroad, Inc. (YVRR) has agreed to grant, pursuant to a prospective written trackage rights agreement,\\1\\ restricted local and overhead trackage rights to BNSF Railway Company (BNSF...

  10. OCCUPATIONAL SAFETY AND HEALTH– VECTOR OF CORPORATE SOCIAL RESPONSIBILITY IN ROMANIAN COMPANIES

    Directory of Open Access Journals (Sweden)

    Geanina Constanța SPĂTARU (PRAVĂȚ

    2015-11-01

    The purpose of this article is to investigate the local reports of the corporate social responsibility of the companies that function in Romania, through their own web page and to make an analysis of the occupational safety and health component as presented in the CSR reports of these companies.

  11. Regulation of the inter-provincial establishment of companies: applying the private interest approach to China

    NARCIS (Netherlands)

    Shen, Guang; Philipsen, N.J.; Philipsen, N.J.; Weishaar, S.E.; Xu, G.

    2016-01-01

    Existing empirical evidence shows that Chinese companies sometimes face difficulties when they try to establish themselves across provinces in China. A significant cause of this problem is the way in which local authorities apply the existing rules on inter-provincial establishment of companies. Mor

  12. A fast method for particle picking in cryo-electron micrographs based on fast R-CNN

    Science.gov (United States)

    Xiao, Yifan; Yang, Guangwen

    2017-06-01

    We propose a fast method to automatically pick protein particles in cryo-EM micrographs, which is now completed manually in practice. Our method is based on Fast R-CNN, with sliding window as the regions proposal solution. To reduce the false positive detections, we set a single class for the major contaminant ice, and pick out all the ice particles in the whole datasets. Tests on the recently-published cryo-EM data of three proteins have demonstrated that our approach can automatically accomplish the human-level particle picking task, and we successfully reduce the test time from 1.5 minutes of previous deep learning method to 2 seconds without any recall or precision losses. Our program is available under the MIT License at https://github.com/xiao1fan/FastParticlePicker.

  13. Structure–activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

    DEFF Research Database (Denmark)

    Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S.

    2010-01-01

    Recently, we described the first small-molecule inhibitor, (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate (1), of the PDZ domain of protein interacting with Ca-kinase 1 (PICK1), a potential drug target against brain ischemia, pain and cocaine addiction. Herein, we explore structure......, docking studies were used to correlate biological affinities with structural considerations for ligand–protein interactions. The most potent analogue obtained in this study showed an improvement in affinity compared to 1 and is currently a lead in further studies of PICK1 inhibition....

  14. Automating the Process of Work-Piece Recognition and Location for a Pick-and-Place Robot in a SFMS

    OpenAIRE

    R. V. Sharan; G. C. Onwubolu

    2014-01-01

    This paper reports the development of a vision system to automatically classify work-pieces with respect to their shape and color together with determining their location for manipulation by an in-house developed pick-and-place robot from its work-plane. The vision-based pick-and-place robot has been developed as part of a smart flexible manufacturing system for unloading work-pieces for drilling operations at a drilling workstation from an automatic guided vehicle designed to transport the w...

  15. 75 FR 76452 - ConocoPhillips Company

    Science.gov (United States)

    2010-12-08

    ... Energy Regulatory Commission ConocoPhillips Company v. Enterprise TE Products Pipeline Company LLC... (ICA), ConocoPhillips Company (ConocoPhillips or Complainant) filed a complaint against Enterprise TE Products Pipeline Company LLC (Enterprise TEPPCO or Respondent) alleging that Enterprise TEPPCO has...

  16. How Do Costume Listing Companies Perform?

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Three Features could be read from the performance of China's costume listing companies in 2007. Brand advantage Different from the display of the textile listing companies in the past several Years,Orand Costume companies have hegun to take up a larger proportion,rather than the Processing export ones,as long as more new companies'listing.

  17. How to Analyze Company Using Social Network?

    Science.gov (United States)

    Palus, Sebastian; Bródka, Piotr; Kazienko, Przemysław

    Every single company or institution wants to utilize its resources in the most efficient way. In order to do so they have to be have good structure. The new way to analyze company structure by utilizing existing within company natural social network and example of its usage on Enron company are presented in this paper.

  18. Heliospheric pick-up ions influencing thermodynamics and dynamics of the distant solar wind

    Directory of Open Access Journals (Sweden)

    H. J. Fahr

    2002-01-01

    Full Text Available Neutral interstellar H-atoms penetrate into the inner heliosphere and upon the event of ionization are converted into pick-up ions (PUIs. The magnetized solar wind flow incorporates these ions into the plasma bulk and enforces their co-motion. By nonlinear interactions with wind-entrained Alfvén waves, these ions are then processed in the comoving velocity space. The complete pick-up process is connected with forces acting back to the original solar wind ion flow, thereby decelerating and heating the solar wind plasma. As we show here, the resulting deceleration cannot be treated as a pure loading effect, but requires adequate consideration of the action of the pressure of PUI-scattered waves operating by the PUI pressure gradient. Hereby, it is important to take into proper account the stochastic acceleration which PUIs suffer from at their convection out of the inner heliosphere by quasi-linear interactions with MHD turbulences. Only then can the presently reported VOYAGER observations of solar wind decelerations and heatings in the outer heliosphere be understood in view of the most likely values of interstellar gas parameters, such as an H-atom density of 0.12 cm-3 . Solar wind protons (SWPs appear to be globally heated in their motion to larger solar distances. Ascribing the needed heat transfer to the action of suprathermal PUIs, which drive MHD waves that are partly absorbed by SWPs, in order to establish the observed SWP polytropy, we can obtain a quantitative expression for the solar wind proton pressure as a function of solar distance. This expression clearly shows the change from an adiabatic to a quasi-polytropic SWP behaviour with a decreasing polytropic index at increasing distances. This also allows one to calculate the average percentage of initial pick-up energy fed into the thermal proton energy. In a first order evaluation of this expression, we can estimate that about 10% of the initial PUI injection energy is eventually

  19. Perancangan dan Proses Pembuatan Inner Door Panel Mobil Pick Up Multiguna

    Directory of Open Access Journals (Sweden)

    Bambang Prayogi

    2014-09-01

    Full Text Available Sejak tahun 2012 Jurusan Teknik Mesin bekerja sama dengan PT. INKA mengembangkan mobil murah multigna. Mobil pick up tersebut diberi nama GEA. Pengembangan dilakukan pada body, chasis dan engine. Sebagai bagian dari body, pintu mobil juga akan dikembangkan. Pada tahun 2013, penelitian terhadap posisi handle pengatur kaca jendela atau window regulator mobil pick up GEA telah dilakukan. Evaluasi tersebut mengharuskan adanya perubahan desain dari inner door panel. Suatu rancangan pengembangan desain inner door panel perlu dilakukan agar inner door panel dapat diproduksi secara massal. Langkah-langkah penelitian yang dilakukan meliputi penyusunan list of requirement untuk pengembangan konsep, analisa getaran dan tegangan yang terjadi pada panel dengan bantuan software CATIA. Selanjutnya perancangan proses pembuatan dan perancangan punch and dies-nya dilakukan. Dari analisa getaran yang dilakukan, dapat diketahui inner door panel memiliki frekuensi natural sebesar 166,94 Hz (10.016,4 rpm artinya panel aman dan tidak terpengaruh oleh getaran dari mesin mobil. Tegangan yang terjadi pada inner door panel akibat gaya pembebanan pada handle pintu bagian dalam adalah 2,9159 x 107 Pa (2,97 Kg/mm2 sehingga lebih kecil dari tegangan ijin materialnya 13,94 Kg/mm2 dan rancangan masih berada dalam kategori aman. Untuk membuat inner door panel dilakukan 3 macam proses pembentukan yaitu trimming, embossing dan piercing. Total gaya pembentukan masing-masing proses sebagai berikut: Gaya pembentukan proses trimming = 48.96 ton, proses embossing = 26.89 ton dan proses piercing = 41.66 ton. Window regulator yang disarankan untuk digunakan pada mobil pick up multiguna ini adalah scissor type window regulator dengan tenaga penggerak manual. Pada perancangan punch and dies, tegangan kompresi masing-masing proses dihitung dan hasilnya adalah sebagai berikut: Tegangan kompresi proses trimming 0.11 Kg/mm2, tegangan kompresi proses embossing 0.28 Kg/mm2, tegangan kompresi

  20. DESTRUCTION AND REALLOCATION OF SKILLS FOLLOWING LARGE COMPANY CLOSURES

    DEFF Research Database (Denmark)

    Holm, Jacob Rubæk; Østergaard, Christian Richter; Olesen, Thomas Roslyng

    2017-01-01

    This paper analyzes what happens to redundant skills and workers when large companies close down and whether their skills are destroyed or reallocated. The analysis is based on a combination of qualitative and quantitative data of the closure of four companies. Getting a job in a skill......-related industry or moving to a spinoff firm leads to skill reallocation. Thus, the result depends on regional idiosyncrasies such as industry structure and urbanization. If local policy makers and the owners exert a coordinated effort, it is possible to create success stories of less skill destruction in urban...