WorldWideScience

Sample records for loading history study

  1. Study on fatigue analysis for operational load histories

    International Nuclear Information System (INIS)

    Wilhelm, Paul; Rudolph, Juergen; Steinmann, Paul

    2013-01-01

    Some laboratories performed fatigue tests in dissolved oxygen water at elevated temperature to better understand the influence of a long hold-time within cyclic loading. Also, the combined effect of complex waveform and surface finish was examined. The data show a less severe influence compared to the prediction model from Argonne National Laboratory; an increase in fatigue life was noticed and attributed to different effects. To evaluate an operational load history with this experimental data an algorithm is developed, which finds hold-times and the examined complex waveform in a stress-time series. All those cycles, which are either geometrically comparable to the complex loading signal or containing a hold period, are evaluated with the test results and not with the formula from Argonne National Laboratory. The reduction of the cumulative usage factor is calculated. Based on this discussion a realistic test condition is derived for further research activities.

  2. Study on inelastic analysis method for structural design (1). Estimation method of loading history effect

    International Nuclear Information System (INIS)

    Tanaka, Yoshihiko; Kasahara, Naoto

    2003-05-01

    The advanced loop-type reactor system, one of the promising concepts in the Feasibility study of the FBR Cycle, adopts many innovative ideas to meet the challenging requirements for safety and economy. As a results, it seems that the structures of the reactor system would be subjected to severer loads than the predecessors. One of the countermeasures to them is the design by inelastic analysis. In the past, many studies showed that structural design by inelastic analysis is much more reasonable than one by conservative elastic analysis. However, inelastic analysis has hardly been adopted in nuclear design so far. One of the reasons is that inelastic analysis has loading history effect, that is, the analysis result would differ depending on the order of loads. It seems to be difficult to find the general solution for the loading history effect. Consequently, inelastic analysis output from the four deferent thermal load histories which consists of the thermal load cycle including the severest cold shock ('C') and the one including the severest hot shock ('H') were compared with each other. From this comparison, it was revealed that the thermal load history with evenly distributed 'H's among 'C's tend to give the most conservative damage estimation derived from inelastic analysis output. Therefore, such thermal load history pattern is proposed for the structural design by inelastic analysis. (author)

  3. A STUDY ON DYNAMIC LOAD HISTORY RECONSTRUCTION USING PSEUDO-INVERSE METHODS

    OpenAIRE

    Santos, Ariane Rebelato Silva dos; Marczak, Rogério José

    2017-01-01

    Considering that the vibratory forces generally cannot be measured directly at the interface of two bodies, an inverse method is studied in the present work to recover the load history in such cases. The proposed technique attempts to reconstruct the dynamic loads history by using a frequency domain analysis and Moore-Penrose pseudo-inverses of the frequency response function (FRF) of the system. The methodology consists in applying discrete dynamic loads on a finite element model in the time...

  4. Impact load time histories for viscoelastic missiles

    International Nuclear Information System (INIS)

    Stoykovich, M.

    1977-01-01

    Generation of the impact load time history at the contact point between a viscoelastic missile and its targets is presented. In the past, in the case of aircraft striking containment shell structure, the impact load history was determined on the basis of actual measurements by subjecting a rigid wall to aircraft crash. The effects of elastic deformation of the target upon the impact load time history is formulated in this paper. The missile is idealized by a linear mass-spring-dashpot combination using viscoelastic models. These models can readily be processed taking into account the elastic as well as inelastic deformations of the missiles. The target is assumed to be either linearly elastic or rigid. In the case of the linearly elastic target, the normal mode theory is used to express the time-dependent displacements of the target which is simulated by lumped masses, elastic properties and dashpots in discrete parts. In the case of Maxwell viscoelastic model, the time-dependent displacements of the missile and the target are given in terms of the unknown impact load time history. This leads to an integral equation which may be solved by Laplace transformation. The normal mode theory is provided. Examples are given for bricks with viscoelastic materials as missiles against a rigid target. (Auth.)

  5. Genome-Wide Association Study Reveals Greater Polygenic Loading for Schizophrenia in Cases With a Family History of Illness

    Science.gov (United States)

    Bigdeli, Tim B.; Ripke, Stephan; Bacanu, Silviu-Alin; Lee, Sang Hong; Wray, Naomi R.; Gejman, Pablo V.; Rietschel, Marcella; Cichon, Sven; St Clair, David; Corvin, Aiden; Kirov, George; McQuillin, Andrew; Gurling, Hugh; Rujescu, Dan; Andreassen, Ole A.; Werge, Thomas; Blackwood, Douglas H.R.; Pato, Carlos N.; Pato, Michele T.; Malhotra, Anil K.; O’Donovan, Michael C.; Kendler, Kenneth S.; Fanous, Ayman H.

    2018-01-01

    Genome-wide association studies (GWAS) of schizophrenia have yielded more than 100 common susceptibility variants, and strongly support a substantial polygenic contribution of a large number of small allelic effects. It has been hypothesized that familial schizophrenia is largely a consequence of inherited rather than environmental factors. We investigated the extent to which familiality of schizophrenia is associated with enrichment for common risk variants detectable in a large GWAS. We analyzed single nucleotide polymorphism (SNP) data for cases reporting a family history of psychotic illness (N = 978), cases reporting no such family history (N = 4,503), and unscreened controls (N = 8,285) from the Psychiatric Genomics Consortium (PGC1) study of schizophrenia. We used a multinomial logistic regression approach with model-fitting to detect allelic effects specific to either family history subgroup. We also considered a polygenic model, in which we tested whether family history positive subjects carried more schizophrenia risk alleles than family history negative subjects, on average. Several individual SNPs attained suggestive but not genome-wide significant association with either family history subgroup. Comparison of genome-wide polygenic risk scores based on GWAS summary statistics indicated a significant enrichment for SNP effects among family history positive compared to family history negative cases (Nagelkerke’s R2 = 0.0021; P = 0.00331; P-value threshold history positive compared to family history negative cases (0.32 and 0.22, respectively; P = 0.031).We found suggestive evidence of allelic effects detectable in large GWAS of schizophrenia that might be specific to particular family history subgroups. However, consideration of a polygenic risk score indicated a significant enrichment among family history positive cases for common allelic effects. Familial illness might, therefore, represent a more heritable form of schizophrenia, as suggested by

  6. Dynamic backcalculation with different load-time histories

    DEFF Research Database (Denmark)

    Madsen, Stine Skov; Levenberg, Eyal

    2017-01-01

    This paper focused attention to the falling weight deflectometer (FWD) load-time history. For a commonly used device, it studied the pulse generation mechanism and the influence of different load histories on backcalculation results. In this connection, a semi-analytic impact theory was first...... for an experimental dataset that resulted from operating an FWD with different loading configurations. It was found that backcalculated parameters are sensitive to the FWD pulse features. Consequently, it is recommended that, whenever advanced pavement characterisation is sought, experimental attention should...

  7. Impact load time histories for viscoelastic missiles

    International Nuclear Information System (INIS)

    Stoykovich, M.

    1977-01-01

    Generation of the impact load time history at the contact point between a viscoelastic missile and its targets is presented. In the past, in the case of aircraft striking containment shell structure, the impact load time history was determined on the basis of actual measurements by subjecting a rigid wall to aircraft crash. The effects of elastic deformation of the target upon the impact load time history is formulated in this paper. The missile is idealized by a linear mass-spring-dashpot combination using viscoelastic models. These models can readily be processed taking into account the elastic as well as inelastic deformations of the missiles. The target is assumed to be either linearly elastic or rigid. In the case of the linearly elastic target, the normal mode theory is used to express the time-dependent displacements of the target which is simulated by lumped masses, elastic properties and dashpots in discrete parts. In the case of Maxwell viscoelastic model, the time-dependent displacements of the missile and the target are given in terms of the unknown impact load time history. This leads to an integral equation which may be solved by Laplace transformation. The normal mode theory is provided. The target structure may be composed of different materials with different components. Concrete and steel structural components have inherently different viscous friction damping properties. Hence, the equivalent modal damping depends on the degree of participation of these components in the modal response. An approximate rule for determining damping in any vibration mode by weighting the damping of each component according to the modal energy stored in each component is considered

  8. Fatigue History and in-situ Loading Studies of the overload Effect Using High Resolution X-ray Strain Profiling

    International Nuclear Information System (INIS)

    Croft, M.; Jisrawi, N.; Zhong, Z.; Holtz, R.; Sadananda, K.; Skaritka, J.; Tsakalakos, T.

    2007-01-01

    High-energy synchrotron X-ray diffraction experiments are used to perform local crack plane strain profiling of 4140 steel compact tension specimens fatigued at constant amplitude, subjected to a single overload cycle, then fatigued some more at constant amplitude. X-ray strain profiling results on a series of samples employing in-situ load cycling are correlated with the crack growth rate (da/dN) providing insight into the da/dN retardation known as the 'overload effect'. Immediately after the overload, the strain under maximum load is greatly reduced but the range of strain, between zero and maximum load, remains unchanged compared to the pre-overload values. At the point of maximum retardation, it is the strain range that is greatly reduced while the maximum-load strain has begun to recover to the pre-overload value. For a sample that has recovered to approximately half of the original da/dN value following the overload, the strain at maximum load is fully recovered while the strain range, though partially recovered, is still substantially reduced. The dominance of the strain range in the overload effect is clearly indicated. Subject to some assumptions, strong quantitative support for a crack growth rate driving force of the suggested form [(K max ) -p (ΔK) p ] γ is found. A dramatic nonlinear load dependence in the spatial distribution of the strain at maximum retardation is also demonstrated: at low load the response is dominantly at the overload position; whereas at high loads it is dominantly at the crack tip position. This transfer of load response away from the crack tip to the overload position appears fundamental to the overload effect for high R-ratio fatigue as studied here

  9. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

    DEFF Research Database (Denmark)

    Bigdeli, Tim B.; Ripke, Stephan; Bacanu, Silviu-Alin

    2016-01-01

    Genome-wide association studies (GWAS) of schizophrenia have yielded more than 100 common susceptibility variants, and strongly support a substantial polygenic contribution of a large number of small allelic effects. It has been hypothesized that familial schizophrenia is largely a consequence...... of inherited rather than environmental factors. We investigated the extent to which familiality of schizophrenia is associated with enrichment for common risk variants detectable in a large GWAS. We analyzed single nucleotide polymorphism (SNP) data for cases reporting a family history of psychotic illness (N...... history subgroup. Comparison of genome-wide polygenic risk scores based on GWAS summary statistics indicated a significant enrichment for SNP effects among family history positive compared to family history negative cases (Nagelkerke's R2=0.0021; P=0.00331; P-value threshold

  10. Loading History Effect on Creep Deformation of Rock

    Directory of Open Access Journals (Sweden)

    Wendong Yang

    2018-06-01

    Full Text Available The creep characteristics of rocks are very important for assessing the long-term stability of rock engineering structures. Two loading methods are commonly used in creep tests: single-step loading and multi-step loading. The multi-step loading method avoids the discrete influence of rock specimens on creep deformation and is relatively time-efficient. It has been widely accepted by researchers in the area of creep testing. However, in the process of multi-step loading, later deformation is affected by earlier loading. This is a key problem in considering the effects of loading history. Therefore, we intend to analyze the deformation laws of rock under multi-step loading and propose a method to correct the disturbance of the preceding load. Based on multi-step loading creep tests, the memory effect of creep deformation caused by loading history is discussed in this paper. A time-affected correction method for the creep strains under multi-step loading is proposed. From this correction method, the creep deformation under single-step loading can be estimated by the super-position of creeps obtained by the dissolution of a multistep creep. We compare the time-affected correction method to the coordinate translation method without considering loading history. The results show that the former results are more consistent with the experimental results. The coordinate translation method produces a large error which should be avoided.

  11. Study experimental and modelisation of strain plastic of iron : rats strains, sensibility to strain rate and loading history

    OpenAIRE

    Afane , Mostapha

    1997-01-01

    This work describes the behavior of a cubical system metal centered : the iron 0.02% C with the help many experimental results. The first part of this thesis is devoted to a bibliographical study whose which the sensitivity of the behavior of metals CC to the speed of deformation, to the temperature is put in obviousness, the indication of the possibility of the appearance of the mecanical twining for the great speeds of deformation, the existence for metals CC of them limit inferior elastici...

  12. A comparison of measured wind park load histories with the WISPER and WISPERX load spectra

    Science.gov (United States)

    Kelley, N. D.

    1995-01-01

    The blade-loading histories from two adjacent Micon 65/13 wind turbines are compared with the variable-amplitude test-loading histories known as the WISPER and WISPERX spectra. These standardized loading sequences were developed from blade flapwise load histories taken from nine different horizontal-axis wind turbines operating under a wide range of conditions in Europe. The subject turbines covered a broad spectrum of rotor diameters, materials, and operating environments. The final loading sequences were developed as a joint effort of thirteen different European organizations. The goal was to develop a meaningful loading standard for horizontal-axis wind turbine blades that represents common interaction effects seen in service. In 1990, NREL made extensive load measurements on two adjacent Micon 65/13 wind turbines in simultaneous operation in the very turbulent environment of a large wind park. Further, before and during the collection of the loads data, comprehensive measurements of the statistics of the turbulent environment were obtained at both the turbines under test and at two other locations within the park. The trend to larger but lighter wind turbine structures has made an understanding of the expected lifetime loading history of paramount importance. Experience in the US has shown that the turbulence-induced loads associated with multi-row wind parks in general are much more severe than for turbines operating individually or within widely spaced environments. Multi-row wind parks are much more common in the US than in Europe. In this paper we report on our results in applying the methodology utilized to develop the WISPER and WISPERX standardized loading sequences using the available data from the Micon turbines. While the intended purpose of the WISPER sequences were not to represent a specific operating environment, we believe the exercise is useful, especially when a turbine design is likely to be installed in a multi-row wind park.

  13. The effects of loading history on fatigue crack growth threshold

    International Nuclear Information System (INIS)

    Ogawa, Takeshi; Tokaji, Keiro; Ochi, Satoshi; Kobayashi, Hideo.

    1987-01-01

    The effects of loading history on threshold stress intensity range (ΔK th ) were investigated in a low alloy steel SFVQ1A (A508 - 3) and a low carbon steel S10C. A single overload and multiple overloads were chosen as loading history. Crack growth and crack closure following the loading histories were measured at load ratios of 0.05 and 0.70. Threshold values were determined as a fatigue limit of preloaded specimens. The ΔK th values increased with increasing overload stress intensity factor (K h ). For a given K h value, multiple overloads produced much larger increase in ΔK th than a single overload and threshold values expressed by maximum stress intensity factor (K max,th ) were almost constant, independent of stress ratio. The results obtained were discussed in terms of crack closure behaviour, and a method was proposed to evaluate the threshold value based on plasticity-induced crack closure. (author)

  14. Effect of loading history on cyclic stress-strain response

    Czech Academy of Sciences Publication Activity Database

    Kunz, Ludvík; Lukáš, Petr; Weiss, B.; Melisova, D.

    2001-01-01

    Roč. 314, 1/2 (2001), s. 1-6 ISSN 0921-5093. [TMS Annual Meeting. Nashville, 12.03.2000-16.03.2000] R&D Projects: GA AV ČR IBS2041001 Institutional research plan: CEZ:AV0Z2041904 Keywords : cyclic plasticity * loading history * mean stress Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 0.978, year: 2001

  15. A probabilistic approach for evaluation of load time history of an aircraft impact

    International Nuclear Information System (INIS)

    Zorn, N.F.; Schueller, G.I.; Riera, J.D.

    1981-01-01

    In the context of an overall structural realiability study for a containment located in the F.R. Germany the external load case aircraft impact is investigated. Previous investigations have been based on deterministic evaluations of the load time history. However, a close analysis of the input parameters, such as the mass distribution, the stiffness of the aircraft, the impact velocity and the impact angle reveal their random properties. This in turn leads to a stochastic load time history the parameters of which have been determined in this study. In other words, the randomness of the input parameters are introduced in the calculation of the load time history and their influence with regard to the load magnitude and frequency content is determined. The statistical parameters such as the mean values and the standard deviation of the mechanical properties are evaluated directly from the design plans of the manufacturer for the aircraft Phantom F4-F. This includes rupture loads, mass distributions etc.. The probability distributions of the crash velocity and impact angle are based on a thorough statistical evaluation of the crash histories of the airplane under consideration. Reference was made only to crashes which occurred in the F.R. Germany. (orig.)

  16. Lumbriculus variegatus loading study

    Data.gov (United States)

    U.S. Environmental Protection Agency — Results from sediment bioaccumulation tests with Lumbriculus variegatus with evaluating the effects of organism loading density. This dataset is associated with the...

  17. DYNAMIC TIME HISTORY ANALYSIS OF BLAST RESISTANT DOOR USING BLAST LOAD MODELED AS IMPACT LOAD

    Directory of Open Access Journals (Sweden)

    Y. A. Pranata

    2012-06-01

    Full Text Available A blast resistant single door was designed to withstand a 0.91 bar blast pressure and 44 ms blast duration. The analysis was done using Dynamic Time History Analysis using Blast Load modeled as Impact Load for given duration. The material properties used have been modified to accommodate dynamic effects. The analysis was done using dynamic finite element method (fem for time of the blast duration, and the maximum/minimum internal forces and displacement were taken from the time history output, in order to know the behavior under blast load and estimate the safety margin of the door. Results obtained from this research indicated that the maximum z-displacement is 1.709 mm, while in the term of serviceability, the permitted is 25 mm. The maximum reaction force is 73,960 N, while the maximum anchor capacity is 82,069 N. On blast condition, the maximum frame stress is 71.71 MPa, the maximum hinge shear stress is 45.28 MPa. While on rebound condition, the maximum frame stress is 172.11 MPa, the maximum hinge shear stress is 29.46 MPa. The maximum door edge rotation is 0.44 degree, which is not exceed the permitted boundary (1.2 degree. Keywords: Dynamic time history, blast resistant door, single door, finite element method.

  18. Lesson Study and History Education

    Science.gov (United States)

    Halvorsen, Anne-Lise; Kesler Lund, Alisa

    2013-01-01

    This article examines the experiences of a group of fifth-grade teachers who used lesson study, a teacher-driven form of professional development, to teach history in a project supported by a Teaching American History Grant. The project addressed the following questions: What does a lesson study cycle for history education look like? What…

  19. Use of plant operating history to define transient loads

    International Nuclear Information System (INIS)

    Dwivedy, K.K.

    1996-01-01

    Fatigue and crack growth analyses of components subjected to transient loads have been under continuous development during the recent past to include effects of environment on the components. The accuracy of the evaluation method on the predicted reliability of the components in the operating environment has become a focus of attention. Methods have integrated available material/component test data to improve evaluation techniques. However, in the area of definition of thermal transient loads the analyst still has to remain conservative, because no realistic guidelines have been developed to define thermal transients and their sequences. Fatigue re-evaluations of components are becoming increasingly necessary in operating plants as they age due to two reasons: (1) Components show age related degradation and cannot be repaired/replaced due to economic/logistic reasons. (2) Components experience transient conditions which were not considered in the original design. In either case, the evaluation of remaining life of components involves definition of transients and their sequence from the time the component was put in service until the end of life. As a common practice, initial plant design transients are used in a conservative definition of sequences to obtain results unrealistic for the situation, which sometimes leads to inaccurate estimate of the remaining life of components. The objective of this paper is to use plant operating history and plant monitoring data to provide procedures and techniques to define realistic transients for evaluation

  20. Fatigue crack threshold relevant to stress ratio, crack wake and loading histories

    International Nuclear Information System (INIS)

    Okazaki, Masakazu; Iwasaki, Akira; Kasahara, Naoto

    2013-01-01

    Fatigue crack propagation behavior was investigated in a low alloy steel which experienced several kind of loading histories. Both the effects of stress ratio, test temperature on the fatigue crack threshold, and the change in the threshold depending on the thermo-mechanical loading histories, were experimentally investigated. It was shown that the thermo-mechanical loading history left its effect along the prior fatigue crack wake resulting in the change of fatigue crack threshold. Some discussions are made on how this type of loading history effect should be treated from engineering point of view. (author)

  1. Business History and Management Studies

    OpenAIRE

    Álvaro-Moya, Adoración; Donzé, Pierre-Yves

    2016-01-01

    This article traces back the origins and nature of business history to stress its potential to dialogue with other social sciences and, in particular, with management studies. It also summarizes the main current trends in business history research to later propose the research lines that editors would like to promote from an interdisciplinary approach and in the direction of a fruitful exchange with scholars active in management and organization studies.

  2. Business History and Management Studies

    Directory of Open Access Journals (Sweden)

    Adoración Álvaro-Moya

    2016-01-01

    Full Text Available This article traces back the origins and nature of business history to stress its potential to dialogue with other social sciences and, in particular, with management studies. It also summarizes the main current trends in business history research to later propose the research lines that editors would like to promote from an interdisciplinary approach and in the direction of a fruitful exchange with scholars active in management and organization studies.

  3. History Through Biography? A Conceptual Research Study.

    Science.gov (United States)

    Johns, Robert W.

    Social studies classroom teachers can enliven high school history courses and motivate students to learn about history by using dramatic or heroic biographies in teaching history. The biographical approach centers on study of the lives, beliefs, and surroundings of historical actors. This approach differs from the "great man" theory of history in…

  4. 1993 Pacific Northwest Loads and Resources Study.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1993-12-01

    The Loads and Resources Study is presented in three documents: (1) this summary of Federal system and Pacific Northwest region loads and resources; (2) a technical appendix detailing forecasted Pacific Northwest economic trends and loads, and (3) a technical appendix detailing the loads and resources for each major Pacific Northwest generating utility. In this loads and resources study, resource availability is compared with a range of forecasted electricity consumption. The forecasted future electricity demands -- firm loads -- are subtracted from the projected capability of existing and {open_quotes}contracted for{close_quotes} resources to determine whether Bonneville Power Administration (BPA) and the region will be surplus or deficit. If resources are greater than loads in any particular year or month, there is a surplus of energy and/or capacity, which BPA can sell to increase revenues. Conversely, if firm loads exceed available resources, there is a deficit of energy and/or capacity, and additional conservation, contract purchases, or generating resources will be needed to meet load growth. The Pacific Northwest Loads and Resources Study analyzes the Pacific Northwest`s projected loads and available generating resources in two parts: (1) the loads and resources of the Federal system, for which BPA is the marketing agency; and (2) the larger Pacific Northwest regional power system, which includes loads and resource in addition to the Federal system. The loads and resources analysis in this study simulates the operation of the power system under the Pacific Northwest Coordination Agreement (PNCA) produced by the Pacific Northwest Coordinating Group. This study presents the Federal system and regional analyses for five load forecasts: high, medium-high, medium, medium-low, and low. This analysis projects the yearly average energy consumption and resource availability for Operating Years (OY) 1994--95 through 2003--04.

  5. On history dependence of stress-strain diagrams and creep curves under variable repeated loading

    International Nuclear Information System (INIS)

    Gokhfeld, D.A.; Sadakov, O.S.; Martynenko, M.E.

    1979-01-01

    The ability of structural alloys to 'keep in memory' the loading prehistory becomes of special importance when inelastic variable repeated loading is considered. There are two main approaches to the development of the mathematical description of this phenomenon: the inclusion of hidden state variables in the incremental theory constitutive equations (a) and construction of proper hereditary functionals (b). In this respect the assumption that the 'memory' regarding the previous deformation history is due to structural nonhomogeneity of actual materials proves to be fruitful. (orig.)

  6. "Why Do I have to Study History?"

    Science.gov (United States)

    Kidwell, F. L.

    1996-01-01

    Recommends beginning classes in history with a short unit on historiography (why and how we study history). This not only provides a context for the succeeding material but also allows for a discussion of inquiry and research methodologies. Defends history-social science as a foundational skill. (MJP)

  7. The Inclusion of Arbitrary Load Histories in the Strength Decay Model for Stress Rupture

    Science.gov (United States)

    Reeder, James R.

    2014-01-01

    Stress rupture is a failure mechanism where failures can occur after a period of time, even though the material has seen no increase in load. Carbon/epoxy composite materials have demonstrated the stress rupture failure mechanism. In a previous work, a model was proposed for stress rupture of composite overwrap pressure vessels (COPVs) and similar composite structures based on strength degradation. However, the original model was limited to constant load periods (holds) at constant load. The model was expanded in this paper to address arbitrary loading histories and specifically the inclusions of ramp loadings up to holds and back down. The broadening of the model allows for failures on loading to be treated as any other failure that may occur during testing instead of having to be treated as a special case. The inclusion of ramps can also influence the length of the "safe period" following proof loading that was previously predicted by the model. No stress rupture failures are predicted in a safe period because time is required for strength to decay from above the proof level to the lower level of loading. Although the model can predict failures during the ramp periods, no closed-form solution for the failure times could be derived. Therefore, two suggested solution techniques were proposed. Finally, the model was used to design an experiment that could detect the difference between the strength decay model and a commonly used model for stress rupture. Although these types of models are necessary to help guide experiments for stress rupture, only experimental evidence will determine how well the model may predict actual material response. If the model can be shown to be accurate, current proof loading requirements may result in predicted safe periods as long as 10(13) years. COPVs design requirements for stress rupture may then be relaxed, allowing more efficient designs, while still maintaining an acceptable level of safety.

  8. Elastic-plastic-creep response of structures under composite time history of loadings

    International Nuclear Information System (INIS)

    Zudans, Z.

    1975-01-01

    High temperature nuclear reactor components are subject to a complex history of thermal and mechanical loading cycles. To evaluate the adequacy of such components, detailed information on the accumulated inelastic strains and strain cycling is required. This work derives the theory, develops efficient numerical techniques accounting for plasticity, creep and overall equilibrium, describes the overall structure of the resulting computer program, and demonstrates the capability of this analysis on a real structure. (Auth.)

  9. Elastic-plastic-creep response of structures under composite time history of loadings

    International Nuclear Information System (INIS)

    Zudans, Z.

    1975-01-01

    The purpose of this work is to derive the theory, to develop efficient numerical techniques accounting for plasticity, creep and overall equilibrium, to describe the overall structure of the resulting computer program, and to demonstrate the capability of this analysis on a real structure. Classical plasticity theory is used to develop a novel method based on the concept of 'plastic stress' for consideration of inelastic behavior. It is shown that materials stres-strain curves can be followed to any desired degree of accuracy both for isotropic and kinematic hardening. It is further shown that for kinematic hardening it is necessary to base the incremental change on the state corresponding to the mean of the initial and the final states in order to satisfy the yield condition at the final state. The equation of state and strain hardening is used to describe the creep behavior. A novel numerical technique to describe a complex load history is developed by using time as a parameter, history breakpoint determination by scanning of various load vectors and by linear interpolation between any two breakpoints in the load history. The 'plastic stress' load vector concept is utilized with iteration and extrapolation to converge to the equilibrium states with simultaneous satisfaction of the stress-strain relations for each of the iterated states. The essential features of the computer program DYPLAS-FSH, based on the theory and techniques described above, and a postprocessor program POR-FSH, based on RDT F9-5T for ratcheting and fatigue evaluation, are identified and discussed. These computer programs are used to analyse the ellipsoidal pressure vessel head of the intermediate heat exchanger of EBR-II, penetrated by two closely spaced non-radial nozzles, subjected to four consecutive composite cycles of complex mechanical and thermal loads

  10. Preservice Social Studies Teachers' Opinions Regarding History Education

    Science.gov (United States)

    Alaca, Eray; Yildirim, Tercan

    2018-01-01

    In Turkey, preservice social studies teachers take history education courses such as Revolution History and Kemalism I-II, Ancient History and Civilization, Pre-Islamic Turkish History and Culture, History of Turkish Education, History of Medieval Age, Ottoman History and Civilization I-II, New and Contemporary History, Contemporary World History,…

  11. Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals.

    Science.gov (United States)

    Fridberg, Daniel J; Gerst, Kyle R; Finn, Peter R

    2013-12-01

    Substance dependence and antisocial psychopathology, such as a history of childhood conduct disorder (HCCD), are associated with impulsive or disadvantageous decision making and reduced working memory capacity (WMC). Reducing WMC via a working memory load increases disadvantageous decision making in healthy adults, but no previous studies have examined this effect in young adults with substance dependence and HCCD. Young adults with substance dependence (SubDep; n=158, 71 female), substance dependence and HCCD (SubDep+HCCD; n=72, 24 female), and control participants (n=152, 84 female) completed a test of decision making (the Iowa Gambling Task; IGT) with or without a concurrent working memory load intended to tax WMC. Outcomes were (i) net advantageous decisions on the IGT, and (ii) preferences for infrequent- versus frequent-punishment decks. SubDep+HCCD men made fewer advantageous decisions on the IGT than control men without a load, but there were no group differences among women in that condition. Load was associated with fewer advantageous decisions for SubDep+HCCD women and control men, but not for men or women in the other groups. Participants showed greater preference for infrequent-punishment, advantageous decks under load as well. There are gender differences in the effects of substance dependence, HCCD, and working memory load on decision making on the IGT. Decision making by control men and SubDep+HCCD women suffered the most under load. Load increases preferences for less-frequent punishments, similar to a delay discounting effect. Future research should clarify the cognitive and neural mechanisms underlying these effects. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  12. Investigation programme and procedure for creep and long-term rupture strength in materials with accounting for stress deviator and loading history

    International Nuclear Information System (INIS)

    Mozharovskaya, T.N.

    1984-01-01

    A programme and procedure are given to study 08Kh18N9 steel at 600 deg C and 15Kh2MFA steel at 550 deg C for creep and long-term strength at different parameters of proportional loading as well as at different parameters under loading in two-link irregular trajectories. This makes it possible to estimate the effect of the kind of a stress deviator, history and prehistory of loading on plastic deformation in creep and on failure under long-term loading

  13. Investigation programme and procedure for creep and long-term rupture strength in materials with accounting for stress deviator and loading history

    Energy Technology Data Exchange (ETDEWEB)

    Mozharovskaya, T N [AN Ukrainskoj SSR, Kiev. Inst. Problem Prochnosti

    1984-11-01

    A programme and procedure are given to study 08Kh18N9 steel at 600 deg C and 15Kh2MFA steel at 550 deg C for creep and long-term strength at different parameters of proportional loading as well as at different parameters under loading in two-link irregular trajectories. This makes it possible to estimate the effect of the kind of a stress deviator, history and prehistory of loading on plastic deformation in creep and on failure under long-term loading.

  14. Recovery of Myocardial Kinematic Function without the Time History of External Loads

    Directory of Open Access Journals (Sweden)

    Zhang Heye

    2010-01-01

    Full Text Available A time-domain filtering algorithm is proposed to recover myocardial kinematic function using output-only measurements without the time history of external loads. The main contribution of this work is that the overall effect of all the external loads on the myocardium is treated as a random variable disturbed by the Gaussian white noise because the external loads of the myocardium are usually unknown in practical exercises. The kernel of our proposed algorithm is an iterative, multiframe, and sequential filtering procedure consisting of a Kalman filter and a least-squares filter. In our proposed implementation, the initial guess of myocardial kinematic function and residual innovation of all the state variables are first computed using a Kalman filter via state space equations only driven by the Gaussian white noise, and then the residual innovation is fed into a least-squares filter to estimate the total external loads of the myocardium. In the end, the initial guess of myocardial kinematic function is corrected using external loads provided by the least-squares filter. After the introduction of the whole structure of our algorithm, we demonstrate the ability of the framework on synthetic data and MR image sequences.

  15. DPC loading feasibility study report

    International Nuclear Information System (INIS)

    Dafoe, R.E.; Lopez, D.A.; Williams, K.L.

    1997-11-01

    Disposal of radioactive wastes now stored at the Idaho Chemical Processing Plant at the Idaho National Engineering and Environmental Laboratory is mandated under a ''Settlement Agreement'' between the Department of Energy and the State of Idaho. This study investigates the feasibility of using the Dry Transfer Cell facility to package waste into Dual Purpose Canisters for interim storage at the adjacent Dry Storage System comprised of an interim storage pad with NUHOMS reg-sign storage modules. The wastes would then be road-ready for eventual disposal in a permanent repository. The operating period for these activities is expected to be from 2015 to 2035

  16. Thermal load histories for North American roof assembles using various cladding materials including wood-thermoplastic composite shingles

    Science.gov (United States)

    J. E. Winandy

    2006-01-01

    Since 1991, thermal load histories for various roof cladding types have been monitored in outdoor attic structures that simulate classic North American light-framed construction. In this paper, the 2005 thermal loads for wood-based composite roof sheathing, wood rafters, and attics under wood-plastic composite shingles are compared to common North American roof...

  17. Preliminary simulation studies of accelerator cavity loading

    International Nuclear Information System (INIS)

    Faehl, R.J.

    1980-06-01

    Two-dimensional simulations of loading effects in a 350 MHz accelerator cavity have been performed. Electron currents of 1-10 kA have been accelerated in 5 MV/m fields. Higher order cavity modes induced by the beam may lead to emittance growth. Operation in an autoaccelerator mode has been studied

  18. History of Pay Equity Studies.

    Science.gov (United States)

    Barbezat, Debra A.

    2002-01-01

    Traces the evolution of salary-equity studies over time, and how the findings have changed with regard to pay differences by gender and race/ethnicity. Reviews the literature on salary equity for both faculty and nonfaculty academic employees. (EV)

  19. Food studies in French History

    DEFF Research Database (Denmark)

    Hedegaard, Liselotte

    The overarching question of this paper is whether it is possible to identify concepts that define a specifically French tradition regarding food. Two themes seem central. The first theme is the relationship between food and place as it emerges in concepts such as authenticity and terroir....... The second theme is the "how" food is eaten and can be studied through concepts such as commensality, synchronisation and structure...

  20. Demonstration of load rating capabilities through physical load testing : Sioux County bridge case study.

    Science.gov (United States)

    2013-08-01

    The objective of this work, Pilot Project - Demonstration of Capabilities and Benefits of Bridge Load Rating through Physical Testing, was to demonstrate the capabilities for load testing and rating bridges in Iowa, study the economic benefit of perf...

  1. Demonstration of load rating capabilities through physical load testing : Johnson County bridge case study.

    Science.gov (United States)

    2013-08-01

    The objective of this work, Pilot Project - Demonstration of Capabilities and Benefits of Bridge Load Rating through Physical Testing, was to demonstrate the capabilities for load testing and rating bridges in Iowa, study the economic benefit of perf...

  2. Demonstration of load rating capabilities through physical load testing : Ida County bridge case study.

    Science.gov (United States)

    2013-08-01

    The objective of this work, Pilot Project - Demonstration of Capabilities and Benefits of Bridge Load Rating through Physical Testing, was to demonstrate the capabilities for load testing and rating bridges in Iowa, study the economic benefit of perf...

  3. Journal of History and Diplomatic Studies

    African Journals Online (AJOL)

    The Journal of History and Diplomatic Studies journal includes papers that focus specifically on developments in Africa and/or the continent's relations with the outside world. All articles must, however, make fresh and original contribution to knowledge and the journal will consider well-researched articles on any aspects of ...

  4. Thermal loading study for FY 1995

    International Nuclear Information System (INIS)

    1996-01-01

    This report provides the results of sensitivity analyses designed to assist the test planners in focusing their in-situ measurements on parameters that appear to be important to waste isolation. Additionally, the study provides a preliminary assessment of the feasibility of certain thermal management options. A decision on thermal loading is a critical part of the scientific and engineering basis for evaluating regulatory compliance of the potential repository for waste isolation. To show, with reasonable assurance, that the natural and engineered barriers will perform adequately under expected repository conditions (thermally perturbed) will require an integrated approach based on thermal testing (laboratory, and in-situ), natural analog observations, and analytic modeling. The Office of Civilian Radioactive Waste Management needed input to assist in the planning of the thermal testing program. Additionally, designers required information on the viability of various thermal management concepts. An approximately 18-month Thermal Loading Study was conducted from March, 1994 until September 30, 1995 to address these issues. This report documents the findings of that study. 89 refs., 71 figs., 33 tabs

  5. Frictional systems under periodic loadsHistory-dependence, non-uniqueness and energy dissipation

    International Nuclear Information System (INIS)

    Barber, J R

    2012-01-01

    Nominally static contacts such as bolted or shrink-fit joints typically experience regions of microslip when subjected to oscillatory loading. This results in energy dissipation, reflected as apparent hysteretic damping of the system, and also may cause the initiation of fretting fatigue cracks. Early theoretical studies of the Hertzian contact problem by Cattaneo and Mindlin were confirmed experimentally by Johnson, who identified signs of fretting damage in the slip annulus predicted by the theory. For many years, tribologists assumed that Melan's theorem in plasticity could be extended to frictional systems — i.e. that if there exists a state of residual stress associated with frictional slip that is sufficient to prevent periodic slip in the steady state, then the system will shake down, regardless of the initial condition. However, we now know that this is true only if there is no coupling between the normal and tangential loading problems, as will be the case notably when contact occurs on a symmetry plane. For all other cases, periodic loading scenarios can be devised such that shakedown occurs for some initial conditions and not for others. The initial condition here might be determined by the assembly protocol — e.g. the order in which a set of bolts is tightened — or by the exact loading path before the steady cycle is attained. This non-uniqueness of the steady state persists at load amplitudes above the shakedown limit, in which case there is always some dissipation, but the dissipation per cycle (and hence both the effective damping and the susceptibility to fretting damage) depends on the initial conditions. This implies that fretting fatigue experiments need to follow a well-defined assembly protocol if reproducible results are to be obtained. We shall also present results showing that when both normal and tangential forces vary in time, the energy dissipation is very sensitive to the relative phase of the oscillatory components, being greatest

  6. Recent Periodicals: Local History, Family and Community History, Cultural Heritage, Folk Studies, Anthropology - A Review (2016

    Directory of Open Access Journals (Sweden)

    R. Vladova

    2017-12-01

    Full Text Available An annual bibliography of papers in the field of local history, family and community history, cultural heritage, folk studies and anthropology, published in 2016, is collected. The inspected journals are: Bulgarian Journal of Science and Education Policy, Chemistry: Bulgarian Journal of Science Education, Current Anthropology, Family and Community History, Folklore, History and Memory, Journal of Family History, Journal of Folklore Research, Past & Present, Winterthur Portfolio. Many of those journals are available at us under subscription.

  7. EDF studies on PWR vessel internal loading

    International Nuclear Information System (INIS)

    Bellet, S.; Vallat, S.

    1998-01-01

    EDF has undertaken some mechanics and thermal-hydraulics studies with the objective of mastering plant phenomena today and in order to numerically predict the behaviour of vessel internals on units planned for the future. From some justifications already underway after in operation incidents (wear and drop time of RCCA rods, fuel deflection, adapter cracks, baffle bolt cracks) we intend to control reactor vessel flows and mechanical behaviour of internal structures. During normal operation, thermal-hydraulic is the main load of vessel internals. The current approach consists of acquiring the capacity to link different calculations, taking care that codes are qualified for physical phenomena and complex 3D geometries. For baffle assembly, a more simple model of this structure has been used to treat the physical phenomena linked to the LOCA transient. Results are encouraging mainly due to code capacity progression (resolution and models), which allows more and more complex physical phenomena to be treated, like turbulence flow and LOCA. (author)

  8. STUDY ON HEAT DYNAMIC LOADING OF RUBBER

    Directory of Open Access Journals (Sweden)

    T. I. Igumenova

    2015-01-01

    Full Text Available A number of studies on heat buildup in tire rubber surface scan method samples using a thermal imaging camera. Investigated the exothermic chemical reaction mechanical destruction rubber when loading designs permanent cyclic stretching with deformation of the working zone 50%. Percentage of deformation of the working zone was chosen on the basis of the actual data on the stretch-compression zone "Rusk" tires, which is the maximum level difference of deformation during run-in. Experiment plan provided for periodic relaxation samples of at least 72 hours for more accurate simulation of operation process of structural products. Created and processed data on temperature changes in samples for bar and line profile for rubber compounds with the introduction of nanomodifiers (fulleren technical carbon in comparison with the control sample without him. The data obtained reflect the nature of heat depending on the composition of the compound. Identified common patterns of thermal nature of physico-chemical process mechanical destruction rubbers. For rubber with nanomodifikatorom there has been an increase in the temperature interval reaction from a minimum to a maximum 2 degrees that is also linked to the rise in the average temperature of the reaction on the histogram also at 2-3 degrees of deformation under the same conditions and the level of cyclic loading. However, the temperature in the control sample that is associated with the beginning of the formation of hardened rubber structures, economies of Mallinz-Petrikeev, occurs with delay twice compared with modified Fullerenes. Measurement of physic-mechanical indicators selected in the course of testing of samples showed the beginning of formation of structure with increased strength of samples in the sample temperature zone that corresponds to the thermal effect of èndotermičeskomu recombination reactions of macromolecules.

  9. The history, development and application of a uniformly applied load wide plate testing machine

    International Nuclear Information System (INIS)

    Quirk, A.; Bevitt, E.

    1989-01-01

    The paper describes early attempts to use a rigid end wide plate testing machine to investigate the behaviour of centre cracked flat plates. Confusing and inconsistent results arising from the above tests lead to a detailed investigation of the loading characteristics of rigid end machines in general and the difficulties which can arise in the interpretation of data obtained by the use of such machines. In order to overcome the above difficulties which stem largely from uneven load distribution, a versatile testing machine was designed which by use of cheap and easily obtainable components allows the application of a uniformly distributed applied load to a centre cracked test plate. The machine which was commissioned in its original form in 1975 was initially capable of testing plate of 820 mm width and 25 or 48 mm thickness up to maximum stress levels of 488 or 254 MPa respectively. The ease of adaptability of the machine has since permitted its capacity to be increased to handle plate up to 2032 mm wide and 76 mm thickness and by use of double-banked hydraulic jacks stress levels up to 350 MPa can be achieved on plate of these dimensions. The configuration of the machine allows adequate access for strain gauging, crack tip observation and measurements, and temperature control, tests having been conducted in the temperature range -40 0 C to 290 0 C. Advantages and potential for further development of the machine are given together with details of two of a number of fracture studies which have been conducted since its commissioning. (orig.)

  10. Studies in the history of Indian mathematics

    CERN Document Server

    2010-01-01

    This volume is the outcome of a seminar on the history of mathematics held at the Chennai Mathematical Institute during January-February 2008 and contains articles based on the talks of distinguished scholars both from the West and from India. The topics covered include: (1) geometry in the oulvasatras; (2) the origins of zero (which can be traced to ideas of lopa in Paoini's grammar); (3) combinatorial methods in Indian music (which were developed in the context of prosody and subsequently applied to the study of tonal and rhythmic patterns in music); (4) a cross-cultural view of the development of negative numbers (from Brahmagupta (c. 628 CE) to John Wallis (1685 CE); (5) Kunnaka, Bhavana and Cakravala (the techniques developed by Indian mathematicians for the solution of indeterminate equations); (6) the development of calculus in India (covering the millennium-long history of discoveries culminating in the work of the Kerala school giving a complete analysis of the basic calculus of polynomial and trigon...

  11. Blogging as Popular History Making, Blogs as Public History: The Singapore Case Study

    Directory of Open Access Journals (Sweden)

    Stephanie Ho

    2007-08-01

    Full Text Available Blogging is a twenty-first century phenomenon that has heralded an age where ordinary people can make their voices heard in the public sphere of the Internet. This article explores blogging as a form of popular history making; the blog as a public history document; and how blogging is transforming the nature of public history and practice of history making in Singapore. An analysis of two Singapore ‘historical’ blogs illustrates how blogging is building a foundation for a more participatory historical society in the island nation. At the same time, the case studies also demonstrate the limitations of blogging and blogs in challenging official versions of history.

  12. A Microstructural Study of Load Distribution in Cartilage: A Comparison of Stress Relaxation versus Creep Loading

    Directory of Open Access Journals (Sweden)

    Ashvin Thambyah

    2015-01-01

    Full Text Available The compressive response of articular cartilage has been extensively investigated and most studies have focussed largely on the directly loaded matrix. However, especially in relation to the tissue microstructure, less is known about load distribution mechanisms operating outside the directly loaded region. We have addressed this issue by using channel indentation and DIC microscopy techniques that provide visualisation of the matrix microstructural response across the regions of both direct and nondirect loading. We hypothesise that, by comparing the microstructural response following stress relaxation and creep compression, new insights can be revealed concerning the complex mechanisms of load bearing. Our results indicate that, with stress relaxation, the initial mode of stress decay appears to primarily involve relaxation of the surface layer. In the creep loading protocol, the main mode of stress release is a lateral distribution of load via the mid matrix. While these two modes of stress redistribution have a complex relationship with the zonally differentiated tissue microstructure and the depth of strain, four mechanostructural mechanisms are proposed to describe succinctly the load responses observed.

  13. Journal of History and Diplomatic Studies: Journal Sponsorship

    African Journals Online (AJOL)

    Journal of History and Diplomatic Studies: Journal Sponsorship. Journal Home > About the Journal > Journal of History and Diplomatic Studies: Journal Sponsorship. Log in or Register to get access to full text downloads.

  14. Why study the history of psychiatry?

    Science.gov (United States)

    Mulder, R T

    1993-12-01

    The history of psychiatry is being neglected. The major psychiatric textbooks no longer offer any overview of psychiatric history. Possible reasons for this indifference are discussed. It is suggested that a knowledge of our history is not only necessary in a general intellectual sense, but also specifically in enabling us to more easily tolerate the incompleteness and ambiguity of many of our concepts. Furthermore, it may help psychiatry to more convincingly explain the reality and consequences of mental illness to a sceptical public.

  15. Sensitivity studies of a PCV under earthquake loading conditions

    International Nuclear Information System (INIS)

    Maraslioglu, B.; Shamshiri, I.

    1987-01-01

    The results point out the special sensitivity of the modeling and the time history method analyses. Due to the lack of more precise general statements in literature and regulations which should help to find an otpimal design, the analyst is challenged to make much efforts in finding realistic, conservative, not overestimated results. For the purpose of more precise data due to the temporal combination in time history method he has to abandon the security supplied by enveloped, smoothed and broadened spectra in response spectrum method analysis (RSMA). It is therefore advisable to prefer RSMA or to perform several calculations with variations of frequency, ground shear modulus and earthquake loading condition. (orig./HP)

  16. Computation of shakedown loads feasibility study

    International Nuclear Information System (INIS)

    Save, M.; Saxce, G. de; Borkowski, A.

    1991-01-01

    Structures submitted to variable loads and temperature fields may enter in a regime of ratcheting where strains and hence structural deflections increase cycle by cycle. It is important to demonstrate that ratcheting is avoided. This happens of course if the structure remains entirely in the elastic regime. However, for more severe loadings, plastic deformations occur and the analyst must then demonstrate that the structure shakes down or adapts. Shakedown may be elastic if after a transient period all strain variations become elastic, or plastic when alternating plasticity occurs. This report addresses plastic shakedown. The problem is treated from the theoretical point of view but also - and this is a very important part of the work - from the numerical and software point of view

  17. The influence of modifications of a fatigue loading history program on fatigue lifetime

    Science.gov (United States)

    Branger, J.

    1972-01-01

    Rectangular specimens of 7075 and 2014 aluminum alloys with two holes (stress concentration factor of 3.24) have been tested under axial fatigue loading on a six-rod test bed with modifications of the loading program, the surface particulars, and the frequency. The length of the precrack stage was investigated by use of a new crack detector. In most cases the two alloys behaved similarly, with similar life to crack start under the same loading. Some overloads lengthened the life. Truncation by omission of the lowest peak loads should be limited to about 20 percent of the ultimate load. Simplifying counting methods gave misleading results. Very thin surface layers of anodizing, protection by vinyl, dry nitrogen atmosphere, as well as stepwise reaming or grinding the surface of the holes, lengthened the life; thick anodized layers shortened the life. Compressing the hole surface by rolling had no influence. Frequencies at about 210 to 240 cpm produced shorter lives than those at 40 cpm. At 5.4 cpm the life was considerably longer. A model to better understand the precrack-stage fatigue mechanism is discussed.

  18. Sensor comparison study for load alleviating wind turbine pitch control

    DEFF Research Database (Denmark)

    Kragh, Knud Abildgaard; Hansen, Morten Hartvig; Henriksen, Lars Christian

    2014-01-01

    As the size of wind turbines increases, the load alleviating capabilities of the turbine controller are becoming increasingly important. Load alleviating control schemes have traditionally been based on feedback from load sensor; however, recent developments of measurement technologies have enabled...... control on the basis of preview measurements of the inflow acquired using, e.g., light detection and ranging. The potential of alleviating load variations that are caused by mean wind speed changes through feed-forward control have been demonstrated through both experiments and simulations in several...... studies, whereas the potential of preview control for alleviating the load variations caused by azimuth dependent inflow variations is less described. Individual or cyclic pitch is required to alleviate azimuth dependent load variations and is traditionally applied through feedback control of the blade...

  19. Feasability Study of Electronic Load Sensing Concept

    DEFF Research Database (Denmark)

    Hansen, Michael Rygaard; Andersen, Torben O.; Pedersen, Henrik C.

    2006-01-01

    to traditional LS-systems, in terms of better control and system utilization possibilities, combined with the increased acceptance and use of electronic sensors in mobile hydraulic machinery. The current work is to evaluate the suitability of an ELS concepts applied to a Sauer Danfoss Series 45 H-frame open...... circuit axial piston pump. Emphasis is on performance robustness with respect to both variations in internal physical parameters of the pump as well as the type of application dependant load that the pump is expected to drive.The research reflect mechatronics as an integrated design process, while...... a synergistic combination of mechanical engineering, electronic engineering, and control engineering are needed in order to get a successful ELS design....

  20. A Preliminary Study on Bucket Foundations under Transient Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo; Nielsen, Søren Kjær

    2013-01-01

    This study aims at investigating the behaviour of monopod bucket foundations through a physical model. The foundation is installed in dense water-saturated sand and is subjected to lateral load applied at different rates. The different loading rates allow for exploring the patterns of response of...

  1. The Effects of Fatigue, Load Carriage, and Physical Activity History on Musculoskeletal Injury Mechanisms

    Science.gov (United States)

    2013-09-01

    20kg, as described in the ACSM’s Guidelines for Exercise Testing and Prescription [3]. Two minutes of rest was given between trials. The assessment was...injuries during military training. Mil Med, 1999. 164(2): p. 153-6. 3. Thompson, W., ACSM’s Guidelines for Exercise Testing and Prescription. 2009...leads to cartilage degeneration and medial knee osteoarthritis (OA) [5,6,7]. Thus, the long- term effect of repetitive high varus knee loading could

  2. Studies in the History of Business Writing.

    Science.gov (United States)

    Douglas, George H., Ed.; Hildebrandt, Herbert W., Ed.

    Because written communication has nearly always been the medium for transmitting information in the business world, these essays are a step toward providing a seminal statement on the history and practice of business writing. The essays in this volume are: "Business Writing and the Spread of Literacy in Late Medieval England" (Malcolm Richardson);…

  3. Study on the HTGR axial fuel loading

    International Nuclear Information System (INIS)

    Tanaka, Ryokichi

    1981-01-01

    In the nuclear and thermal design of reactor cores, it is one of the important targets for reactor safety to flatten fuel temperature distribution as far as possible to prevent local peaking. As a macroscopic method to prevent temperature peaking, it is considered to give exponential type power output distribution in coolant flow direction, while flattening radial power output distribution. Assuming rod-shaped fuel, the distribution of fuel heat generation is given by an exponential function under constant maximum fuel temperature condition in the direction of channel. By applying this function to neutron source distribution, and in a premise that U-235 loading can be changed continuously, the preliminary investigation on no-reflector core by one-dimensional one-group consideration, and then the analytical solution of the diffusion equation for a core with reflectors by two group one-dimensional approximation were carried out. The results of these investigations revealed that the U-235 concentration required for achieving exponential type power output distribution is necessary to have large concentration gradient up to the distance equivalent to the length of a few fuel elements from the core inlet, but it is sufficient to have constant concentration in downstream fuel elements, which is 0.8 to 0.9 times as much as the average value along the channel, except for large flow rate channel. (Wakatsuki, Y.)

  4. Valeriu Bologa’s studies on the history of science

    Science.gov (United States)

    BÂRSU, CRISTIAN

    2016-01-01

    History of science is a vast and complex domain, comprising many sub-domains, such as: the history of medicine, history of chemistry, history of physics etc. Different specialists in these sub-domains, trying to reach the general and integrative understanding of the history of science, succeeded only after they acquired a rich scientific experience in their fields of activity. One of the scientists who had interesting papers on the history of science was Valeriu Bologa (1892–1971). He was the first Romanian professor of history of medicine. Our paper presents some milestones regarding his preoccupations on the history of science. The aim of our study is to prove that, although he was primarily a historian of medicine, he surpassed this framework, proving to be a skillful historian of science. The topics of his works on the history of science included: the value of the unity of science, the ethical aspects of science during centuries, the interferences between the history of science and the history of medicine etc. PMID:27547069

  5. Valeriu Bologa's studies on the history of science.

    Science.gov (United States)

    Bârsu, Cristian

    2016-01-01

    History of science is a vast and complex domain, comprising many sub-domains, such as: the history of medicine, history of chemistry, history of physics etc. Different specialists in these sub-domains, trying to reach the general and integrative understanding of the history of science, succeeded only after they acquired a rich scientific experience in their fields of activity. One of the scientists who had interesting papers on the history of science was Valeriu Bologa (1892-1971). He was the first Romanian professor of history of medicine. Our paper presents some milestones regarding his preoccupations on the history of science. The aim of our study is to prove that, although he was primarily a historian of medicine, he surpassed this framework, proving to be a skillful historian of science. The topics of his works on the history of science included: the value of the unity of science, the ethical aspects of science during centuries, the interferences between the history of science and the history of medicine etc.

  6. Learning Historical Thinking with Oral History Interviews: A Cluster Randomized Controlled Intervention Study of Oral History Interviews in History Lessons

    Science.gov (United States)

    Bertram, Christiane; Wagner, Wolfgang; Trautwein, Ulrich

    2017-01-01

    The present study examined the effectiveness of the oral history approach with respect to students' historical competence. A total of 35 ninth-grade classes (N = 900) in Germany were randomly assigned to one of four conditions--live, video, text, or a (nontreated) control group--in a pretest, posttest, and follow-up design. Comparing the three…

  7. A model for voltage collapse study considering load characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, L B [Companhia de Energia Eletrica da Bahia (COELBA), Salvador, BA (Brazil)

    1994-12-31

    This paper presents a model for analysis of voltage collapse and instability problem considering the load characteristics. The model considers fundamentally the transmission lines represented by exact from through the generalized constants A, B, C, D and the loads as function of the voltage, emphasizing the cases of constant power, constant current and constant impedance. the study treats of the system behavior on steady state and presents illustrative graphics about the problem. (author) 12 refs., 4 figs.

  8. Dynamics of CD4 Lymphocytes and Viral Load at the Natural History of Perinatal HIV-infection

    Directory of Open Access Journals (Sweden)

    T. A. Daminov

    2015-01-01

    Full Text Available This article presents the analysis of indicators of CD4 lymphocyte count and viral load in the natural history (in the absence of ART in perinatally HIV-infected children. It was revealed that perinatal way of transmission is characterized by a higher rate of immunodeficiency progression. It may be associated with intrauterine infection, as well as an early defeat HIV immature immune system of the child. The concentration of virus in perinatally infected children since the beginning of the observation and in 30 months after infection is more than in parenterally infected children in 5 and 2 times, respectively, which determines a infavourable version of the disease in perinatally infected children.

  9. "I'm Buffy, and you're history": Putting fan studies into history [editorial

    Directory of Open Access Journals (Sweden)

    Nancy Reagin

    2011-03-01

    Full Text Available This essay kicks off the special historical issue of Transformative Works and Cultures by offering an overview of the ways in which fan communities have been studied by academic historians, and how fan studies has written the history of fan communities. The essay discusses historical work done by amateur fan historians throughout the 20th century; what academic historians can offer fan communities; why academic historians could benefit from studying fandoms as part of the history of popular culture; and what fan studies as a discipline might gain from a broader historical analysis of fandoms.

  10. Heat load material studies: Simulated tokamak disruptions

    International Nuclear Information System (INIS)

    Gahl, J.M.; McDonald, J.M.; Zakharov, A.; Tserevitinov, S.; Barabash, V.; Guseva, M.

    1991-01-01

    It is clear that an improved understanding of the effects of tokamak disruptions on plasma facing component materials is needed for the ITER program. very large energy fluxes are predicted to be deposited in ITER and could be very damaging to the machine. During 1991, Sandia National Laboratories and the University of New Mexico conducted cooperative tokamak disruption simulation experiments at several Soviet facilities. These facilities were located at the Efremov Institute in Leningrad, the Kurchatov Atomic Energy Institute (Troisk and Moscow) and the Institute for Physical Chemistry of the Soviet Adademy of Sciences in Moscow. Erosion of graphite from plasma stream impact is seen to be much less than that observed with laser or electron beams with similar energy fluxes. This, along with other data obtained, seem to suggest that the ''vapor shielding'' effect is a very important phenomenon in the study of graphite erosion during tokamak disruption

  11. Thermal loading study for FY 1996. Volume 1

    International Nuclear Information System (INIS)

    1996-01-01

    The primary objective of this study was to provide recommendations for Mined Geologic Disposal System requirements affected by thermal loading that will provide sufficient definition to facilitate development of design concepts and support life cycle cost determinations. The study reevaluated and/or redefined selected thermal goals used for design and are currently contained in the requirements documents or the Controlled Design Assumption Document. The study provided recommendations as to what, if any, actions (such as edge loading and limiting of the heat variability between waste packages) are needed and must be accommodated in the design. Additionally, the study provided recommendations as to what alternative thermal loads should be maintained for continued flexibility. Section 1 provides the study objective, background, scope, and organization of the report. Section 2 documents the requirements and standards to include quality assurance (QA) requirements, any requirements used or evaluated, and the inputs and assumptions considered. Section 3 provides the analysis and recommendations for the thermal goals reevaluation. Section 4 discusses the evaluation of edge loading and provides conclusions. Section 5 provides the analyses done to establish recommendations as to what requirements need to be implemented to either limit or manage the amount of heat output variability that may occur. Section 6 discusses alternate thermal loadings; Section 7 provides the study conclusions and recommendations; Section 8 provides the references, standards, and regulations; and Section 9 contains the acronym list

  12. [History of studies of alcohol toxicology].

    Science.gov (United States)

    Konopka, Tomasz

    2010-01-01

    The early history of forensic alcohology was presented, based on writings from the beginning of the 20th century and numerous forensic medical protocols from autopsies performed in Institute of Forensic Medicine in Cracow in the 19th and 20th century. Ethanol has not been considered a poison for a long time. Suspicion of its toxic effect resulted from cases of deaths as a results of people betting who can drink more alcohol. In case of alcohol poisoning, autopsy does not show any typical changes, so the poisonings have not been recognized for many years. At the beginning of the 20th century, the first chemical tests appeared. They were able to detect the presence of alcohol in tissues. A method for measuring the amount of alcohol in blood was also developed. The majority of methods were based on distillation of blood and inspection of the resultant distillate by physical methods (interferometry, colorimetry, refractometry, gravimetry, measuring thermal expansion and electrical conduction) or chemical methods using different reactions (oxidation of alcohol to acetic acid, reducing potassium dichromate by alcohol, alkylation of iodine by alcohol) and marking the amount of products of reaction by titration. Distillation of blood samples required complicated chemical devices and was very time consuming. Erik Widmark suggested a certain method in 1920, in which distillation of a blood sample took place in the same container, in which titration was performed earlier--the so-called Widmark's Flask. It allowed for distilling many samples in an incubator at the same time and dramatically shortened the time of research. Widmark's method was applied to testing drivers and people who committed crimes and was used in the whole world for many following years.

  13. Dynamic axle and wheel loads identification: laboratory studies

    Science.gov (United States)

    Zhu, X. Q.; Law, S. S.

    2003-12-01

    Two methods have been reported by Zhu and Law to identify moving loads on the top of a bridge deck. One is based on the exact solution (ESM) and the other is based on the finite element formulation (FEM). Simulation studies on the effect of different influencing factors have been reported previously. This paper comparatively studies the performances of these two methods with experimental measurements obtained from a bridge/vehicle system in the laboratory. The strains of the bridge deck are measured when a model car moves across the bridge deck along different paths. The moving loads on the bridge deck are identified from the measured strains using these two methods, and the responses are reconstructed from the identified loads for comparison with the measured responses to verify the performances of these methods. Studies on the identification accuracy due to the effect of the number of vibration mode used, the number of measuring points and eccentricities of travelling paths are performed. Results show that the ESM could identify the moving loads individually or as axle loads when they are travelling at an eccentricity with the sensors located close to the travelling path of the forces. And the accuracy of the FEM is dependent on the amount of measured information used in the identification.

  14. Study on Predicting Axial Load Capacity of CFST Columns

    Science.gov (United States)

    Ravi Kumar, H.; Muthu, K. U.; Kumar, N. S.

    2017-11-01

    This work presents an analytical study and experimental study on the behaviour and ultimate load carrying capacity of axially compressed self-compacting concrete-filled steel tubular columns. Results of tests conducted by various researchers on 213 samples concrete-filled steel tubular columns are reported and present authors experimental data are reported. Two theoretical equations were derived for the prediction of the ultimate axial load strength of concrete-filled steel tubular columns. The results from prediction were compared with the experimental data. Validation to the experimental results was made.

  15. Micromechanical studies of cyclic creep fracture under stress controlled loading

    DEFF Research Database (Denmark)

    van der Giessen, Erik; Tvergaard, Viggo

    1996-01-01

    is based on numerical unit cell analyses for a planar polycrystal model with the grains and grain boundaries modeled individually, in order to investigate the interactions between the mechanisms involved and to account for the build-up of residual stress fields during cycling. The behaviour of a limiting......This paper deals with a study of intergranular failure by creep cavitation under stress-controlled cyclic loading conditions. Loading is assumed to be slow enough that diffusion and creep mechanisms (including grain boundary sliding) dominate, leading to intergranular creep fracture. This study...

  16. Cavitation effects in LMFBR containment loading - a sensitivity study

    International Nuclear Information System (INIS)

    Jones, A.V.

    1981-01-01

    The motivation for and design of a sensitivity study into the effects of bulk cavitation of the coolant upon predicted roof loadings and vessel wall loadings and deformations are presented. The study is designed to cover simple and sophisticated models of cavitation in various geometries and with two types of energy source to represent both an explosion charge and the lower pressure expansion behavior expected in a real core disruptive accident. Effects of change of scale (from reactor to model), of coolant tensile strength, of reactor aspect ratio and design (presence or absence of an internal tank) and of reactor structural resistance (rigid or deforming outer tank) are all examined in order to provide a quantitative answer to the question 'how and to what extent does dynamic cavitation affect the containment loading process.'. (orig.)

  17. Preservice History and Social Studies Teachers' Perceptions of Outdoor History Teaching

    Science.gov (United States)

    Yildirim, Tercan; Yazici, Fatih

    2017-01-01

    Creating positive attitude and behaviors in individuals towards the environment he/she lives in, outdoor teaching aims at bringing the individual together with unwritten evidences by making use of historical environment and resources when considered especially within the scope history and social studies teaching. Using relational screening model,…

  18. Loading technique for dynamic response studies of geological materials

    International Nuclear Information System (INIS)

    Butler, R.I.; Forrestal, M.J.

    1979-04-01

    A loading technique to study the dynamic response of tuff was explored. Loading is provided by electrically exploding etched copper mesh patterns with current from a capacitor discharge. Pressure pulses with peak pressures up to 1.25 kbar and 0.10 to 0.20 ms durations were measured with a pressure bar. The upper value of peak pressure was limited by the strength of the experimental apparatus, and higher pressure generation is possible with a redesign of test hardware. 6 figures, 2 tables

  19. The history of pharmacy studies in Croatia.

    Science.gov (United States)

    Kujundzić, N; Inić, S

    2014-02-01

    The first study of pharmacy on Croatian territory was founded in the early 19th century (1806-1813). Vicencio Dandolo (1758-1819), a pharmacist from Venice who was Napoleon's governor of Dalmatia, established a lyceum in Zadar in 1806. It included education for pharmacists. The Lyceum (later the Central School) was closed in 1811. The founding of the modern University of Zagreb (1874) and its Department of Mathematics and Natural Sciences (1876) created the conditions for the development of university education for pharmacists. The study of pharmacy was introduced at the University of Zagreb in 1882 through the efforts of the Croatian-Slavonian Pharmaceutical Association and the professors of the Faculty of Philosophy. The study went through a series of reforms. The most significant one came with the introduction of the four-year study of pharmacy and the establishment of the Pharmacy Department of the Faculty of Philosophy (1928). The independent Faculty of Pharmacy (today's Faculty of Pharmacy and Biochemistry) was founded at the University of Zagreb in 1942. Since 1989, it has had two separate studies (Pharmacy and Medical Biochemistry).

  20. Studies in the history of astronomy. Number 19, 1987

    Science.gov (United States)

    Gurshtein, A. A.

    Papers are presented on such topics as the history of the exploration of Venus, the history of the discovery of the relic radiation, Copernicus' star catalog, Euler's contribution to potential theory in connection with the theory of the earth's figure, the role of astrology in ancient culture, and the history of the study of astronomical refraction. Attention is also given to astronomy in Kazakhstan during the Second World War, the contribution of Arago to the development of astrophysics instrumentation, and the work on astronomy written by Kirik of Novgorod in the year 1136.

  1. A geometrical approach to determine reorientation start and continuation conditions in ferromagnetic shape memory alloys considering the effects of loading history

    International Nuclear Information System (INIS)

    Shirani, M; Kadkhodaei, M

    2014-01-01

    Ferromagnetic shape memory alloys (FSMAs) and magnetic shape memory alloys (MSMAs) are metallic alloys that can undergo inelastic responses when exposed to magnetic fields. Several constitutive models have been proposed so far to model the behaviors of FSMAs. In this work, the effects of loading history on reorientation start conditions are considered, and it is shown that reorientation start conditions are not fixed values; rather, they change with respect to the amount of loading history. To consider the effects of loading history on reorientation start conditions, an available phase diagram in stress-field space is generalized to reorientation surfaces in stress-field-loading history space. Correspondingly, kinetic laws are derived in a continuum framework to be used with the reorientation surfaces to determine the amount of the martensitic variant 2 volume fraction. Based on the geometry of the reorientation surfaces, conditions that must be satisfied to ensure the continuation of reorientations are obtained. Available experimental findings validate the proposed model and the reorientation surfaces. (paper)

  2. The Utilization of Local History in Teaching American Religious History: A Gilded Age and Progressive Era North Dakota Case Study

    Science.gov (United States)

    Price, Christopher Neal

    2013-01-01

    Teachers of college-level courses on American religious history generally leave out the importance of local and regional histories when telling the story of religion in America. The study of local history provides a fertile ground for understanding broad national trends in a local context. This dissertation focuses upon a little-studied religious…

  3. Lake Titicaca: History and current studies

    International Nuclear Information System (INIS)

    Paredes Riveros, M.A.; Gonfiantini, R.

    1999-01-01

    This article summarizes results of Titicaca lake water balance studies including the findings of the IAEA Technical Cooperation Project RLA/08/022. Direct precipitation over the lake accounts for about 55% of the water inflow and rivers and streams provide about 45% of the water inflow. Diffuse groundwater leakage into the lake from coastal aquifers is believed to represent a negligible term of water balance. Evaporation from the lake is strong and accounts for more than 95% of the water losses. The isotopic and chemical composition data obtained within the frameworks of the IAEA Technical Cooperation Project RLA/08/022 are discussed

  4. Lake Titicaca: History and current studies

    Energy Technology Data Exchange (ETDEWEB)

    Paredes Riveros, M A [PELT, Puno (Peru); Gonfiantini, R [Istituto di Geocronologia e Geochimica Isotopica del CNR, Pisa (Italy)

    1999-12-01

    This article summarizes results of Titicaca lake water balance studies including the findings of the IAEA Technical Cooperation Project RLA/08/022. Direct precipitation over the lake accounts for about 55% of the water inflow and rivers and streams provide about 45% of the water inflow. Diffuse groundwater leakage into the lake from coastal aquifers is believed to represent a negligible term of water balance. Evaporation from the lake is strong and accounts for more than 95% of the water losses. The isotopic and chemical composition data obtained within the frameworks of the IAEA Technical Cooperation Project RLA/08/022 are discussed.

  5. The loading history of trace metals and nutrients in Altata-Ensenada del Pabellon, lagoon complex, northwestern Mexico

    International Nuclear Information System (INIS)

    Ruiz-Fernandez, A.C.; Paez-Osuna, F.; Soto-Jimenez, M.; Hillaire-Marcel, C.; Ghaleb, B.

    2003-01-01

    This paper summarizes the geochemical investigations about the origin and loading history of some trace metals (Ag, Cu and Zn) and nutrients (N and P) in the coastal lagoon complex of Altata-Ensenada del Pabellon, Mexico, by using the radioactive chronometers 210 Pb and 228 Th and the stable isotopes of C and N. The examination of sediment cores collected at different locations in the lagoon system identified a slight enrichment in metals and nutrients in some points, which was mainly associated to organic matter accumulation. Stable C and N isotope ratios revealed wastewater inputs to the lagoon system and the 210 Pb geochronology showed that anthropogenic impact started 50 years ago, with the beginning of the agriculture development and the associated urban growth of the surrounding area. Several atypical 210 Pb and 228 Th/ 232 Th profiles demonstrated that biological and physical disturbances are common phenomena in these environments, that frequently mask the pollution records; and therefore, considering that the contaminated sediments at some locations in the lagoon system are frequently resuspended and re-oxygenated, the pollutants will continue to be easily remobilized in the food chain

  6. SMR Re-Scaling and Modeling for Load Following Studies

    Energy Technology Data Exchange (ETDEWEB)

    Hoover, K.; Wu, Q.; Bragg-Sitton, S.

    2016-11-01

    This study investigates the creation of a new set of scaling parameters for the Oregon State University Multi-Application Small Light Water Reactor (MASLWR) scaled thermal hydraulic test facility. As part of a study being undertaken by Idaho National Lab involving nuclear reactor load following characteristics, full power operations need to be simulated, and therefore properly scaled. Presented here is the scaling analysis and plans for RELAP5-3D simulation.

  7. A study of binder materials subjected to isentropic compression loading

    International Nuclear Information System (INIS)

    Hall, Clint Allen; Orler, E. Bruce; Sheffield, Steve A.; Gustavsen, Rick L.; Sutherland, Gerrit; Baer, Melvin R.; Hooks, D.E.

    2005-01-01

    Binders such as Estane, Teflon, Kel F and HTPB are typically used in heterogeneous explosives to bond polycrystalline constituents together as an energetic composite. Combined theoretical and experimental studies are underway to unravel the mechanical response of these materials when subjected to isentropic compression loading. Key to this effort is the determination of appropriate constitutive and EOS property data at extremely high stress-strain states as required for detailed mesoscale modeling. The Sandia Z accelerator and associated diagnostics provides new insights into mechanical response of these nonreactive constituents via isentropic ramp-wave compression loading. Several thicknesses of samples, varied from 0.3 to 1.2 mm, were subjected to a ramp load of ∼42 Kbar over 500 ns duration using the Sandia Z-machine. Profiles of transmitted ramp waves were measured at window interfaces using conventional VISAR. Shock physics analysis is then used to determine the nonlinear material response of the binder materials. In this presentation we discuss experimental and modeling details of the ramp wave loading ICE experiments designed specifically for binder materials.

  8. 1998 Pacific Northwest Loads and Resources Study: The White Book

    International Nuclear Information System (INIS)

    1998-01-01

    The Pacific Northwest Loads and Resources Study (White Book) is published annually by BPA and establishes the planning basis for supplying electricity to customers. It serves a dual purpose. First, the White Book presents projections of regional and Federal system load and resource capabilities, along with relevant definitions and explanations. Second, the White Book serves as a benchmark for annual BPA determinations made pursuant to the 1981 regional power sales contracts. Specifically, BPA uses the information in the White Book for determining the notice required when customers request to increase or decrease the amount of power purchased from BPA. The White Book compiles information obtained from several formalized resource planning reports and data submittals, including those from the Northwest Power Planning Council (Council) and the Pacific Northwest Utilities Conference Committee (PNUCC). The White Book is not an operational planning guide, nor is it used for inventory planning to determine BPA revenues. Operation of the Federal Columbia River Power System (FCRPS) is based on a set of criteria different from that used for resource planning decisions. Operational planning is dependent upon real-time or near-term knowledge of system conditions, including expectations of river flows and runoff, market opportunities, availability of reservoir storage, energy exchanges, and other factors affecting the dynamics of operating a power system. The 1998 White Book is presented in two documents: (1) this summary of Federal system and Pacific Northwest region loads and resources; and (2) a technical appendix detailing the loads and resources for each major Pacific Northwest generating utility. This analysis updates the December 1997 Pacific Northwest Loads and Resources Study

  9. 1998 Pacific Northwest Loads and Resources Study: The White Book.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1998-12-01

    The Pacific Northwest Loads and Resources Study (White Book) is published annually by BPA and establishes the planning basis for supplying electricity to customers. It serves a dual purpose. First, the White Book presents projections of regional and Federal system load and resource capabilities, along with relevant definitions and explanations. Second, the White Book serves as a benchmark for annual BPA determinations made pursuant to the 1981 regional power sales contracts. Specifically, BPA uses the information in the White Book for determining the notice required when customers request to increase or decrease the amount of power purchased from BPA. The White Book compiles information obtained from several formalized resource planning reports and data submittals, including those from the Northwest Power Planning Council (Council) and the Pacific Northwest Utilities Conference Committee (PNUCC). The White Book is not an operational planning guide, nor is it used for inventory planning to determine BPA revenues. Operation of the Federal Columbia River Power System (FCRPS) is based on a set of criteria different from that used for resource planning decisions. Operational planning is dependent upon real-time or near-term knowledge of system conditions, including expectations of river flows and runoff, market opportunities, availability of reservoir storage, energy exchanges, and other factors affecting the dynamics of operating a power system. The 1998 White Book is presented in two documents: (1) this summary of Federal system and Pacific Northwest region loads and resources; and (2) a technical appendix detailing the loads and resources for each major Pacific Northwest generating utility. This analysis updates the December 1997 Pacific Northwest Loads and Resources Study.

  10. Thermal loading study for FY 1996. Volume 2

    International Nuclear Information System (INIS)

    1996-01-01

    The primary objective of this study was to provide recommendations for Mined Geologic Disposal System requirements affected by thermal loading that will provide sufficient definition to facilitate development of design concepts and support life cycle cost determinations. The study reevaluated and/or redefined selected thermal goals used for design and are currently contained in the requirements documents or the Controlled Design Assumption Document. The study provided recommendations as to what, if any, actions (such as edge loading and limiting of the heat variability between waste packages) are needed and must be accommodated in the design. Additionally, the study provided recommendations as to what alternative thermal loads should be maintained for continued flexibility. This report contains seven appendices: Technical basis for evaluation of thermal goals below the potential nuclear was repository at Yucca Mountain; Thermal-mechanical evaluation of the 200 C drift-wall temperature goal; Evaluation of ground stability and support; Coupled ventilation and hydrothermal evaluations; Heat flow and temperature calculations for continuously ventilated emplacement drifts; Thermal management using aging and/or waste package selection; and Waste stream evaluations

  11. Stability Study of Anthropomorphic Robot Antares under External Load Action

    Science.gov (United States)

    Kodyakov, A. S.; Pavlyuk, N. A.; Budkov, V. Yu; Prakapovich, R. A.

    2017-01-01

    The paper presents the study of the behavior of the major structural elements of the lower limbs of anthropomorphic robot Antares under the influence of different types of loads (torsion, fracture). We have determined the required values for actuators torques for motion of the robot in space. The maximum values of torques are 5 Nm and 5.2 Nm respectively, and are able to withstand the upper and lower leg structures.

  12. Influence of roof motion in LMFBR containment loading studies

    International Nuclear Information System (INIS)

    Potter, R.; Lancefield, M.J.; Sidoli, J.E.A.; Broadhouse, B.J.; Green, R.S.

    1982-01-01

    Following an HCDA the reactor roof may be threatened by coolant impact. Recent trends in CDFR roof design suggest that roof movement during the impact process may reduce the roof loading as a result of the fluid-structure interaction. The paper describes analytic studies of the phenomena, extensions to the SEURBNUK containment code to the roof flexibility and fluid-structure coupling, and results of experiments which confirm the reduced impulse and provide validation of the mathematical modelling

  13. Study of elevated temperature design standard against thermal loads

    International Nuclear Information System (INIS)

    Kasahara, Naoto; Asayama, Tai; Morishita, Masaki

    2001-01-01

    Elevated temperature components must be designed against both pressure and thermal loads. In the case of sodium circuits of fast breeder reactors, a restriction from the pressure load becomes small because of the high boiling point of sodium. Design approaches for thermal loads (displacement-controlled) are compared with those against pressure loads (load-controlled). Considering differences between those two approaches, a concept of the elevated temperature design standard that takes the nature of thermal loads fully into account is proposed. This concept is a basis of load evaluation techniques and an inelastic analysis guide, that are being developed. Finally, problems and plans to realize the above concept are discussed. (author)

  14. Experimental Study on Pipe Sections against Impact Loading

    Directory of Open Access Journals (Sweden)

    Engin GÜCÜYEN

    2018-02-01

    Full Text Available Pipelines are significant structural systems that transfer necessary materials from one place to another. They are under the effect of static and dynamic loads during their service lives. Investigations have become important to determine the effects of sudden dynamic loads with technological developments. Researchers study the mechanical properties of different materials and structural members under dynamic effects such as earthquake, wind, blast, rock falling and vehicle crushing. For this purpose, different test setups have been developed to investigate the behaviour of test members. In this study, galvanized and water filled galvanized pipe sections having three different diameter values are produced in a laboratory to perform tests under impact loading. The behaviour of the pipes is determined by free falling test apparatus. In addition, measurement devices as accelerometer, dynamic force sensor, lvdt, and data logger are used in the experimental program. So, acceleration, impact force, and displacement values are obtained during the tests. Besides, damage developments of the pipes are also observed to determine the impact resistances of test members. The results are compared to each other and it is stated that while acceleration and impact force values decrease, displacement values increase as the test members approach to collapse damage situation.

  15. Interrupting History: Rethinking History Curriculum after "The End of History". Counterpoints: Studies in the Postmodern Theory of Education. Volume 404

    Science.gov (United States)

    Parkes, Robert John

    2011-01-01

    Since the emergence of postmodern social theory, history has been haunted by predictions of its imminent end. Postmodernism has been accused of making historical research and writing untenable, encouraging the proliferation of revisionist histories, providing fertile ground for historical denial, and promoting the adoption of a mournful view of…

  16. Study on Impact Loading and Humerus Injury for Baseball

    Science.gov (United States)

    Sakai, Shinobu; Oda, Juhachi; Yonemura, Shigeru; Sakamoto, Jiro

    In the United States and Japan, baseball is a very popular sport played by many people. However, the ball used is hard and moves fast. A professional baseball pitcher in good form can throw a ball at speeds upwards of 41.7m/s (150km/hr). If a ball at this speed hits the batter, serious injury can occur. In this paper we will describe our investigations on the impact of a baseball with living tissues by finite element analysis. Baseballs were projected at a load cell plate using a specialized pitching machine. The dynamic properties of the baseball were determined by comparing the wall-ball collision experimentally measuring the time history of the force and the displacement using dynamic finite element analysis software (ANSYS/ LS-DYNA). The finite element model representing a human humerus and its surrounding tissue was simulated for balls pitched at variable speeds and pitch types (knuckle and fastball). In so doing, the stress distribution and stress wave in the bone and soft tissue were obtained. From the results, the peak stress of the bone nearly yielded to the stress caused by a high fast ball. If the collision position or direction is moved from the center of the upper arm, it is assumed that the stress exuded on the humerus will be reduced. Some methods to reduce the severity of the injury which can be applied in actual baseball games are also discussed.

  17. Comparative Study of Load Testing Tools: Apache JMeter, HP LoadRunner, Microsoft Visual Studio (TFS, Siege

    Directory of Open Access Journals (Sweden)

    Rabiya Abbas

    2017-12-01

    Full Text Available Software testing is the process of verifying and validating the user’s requirements. Testing is ongoing process during whole software development. Software testing is characterized into three main types. That is, in Black box testing, user doesn’t know domestic knowledge, internal logics and design of system. In white box testing, Tester knows the domestic logic of code. In Grey box testing, Tester has little bit knowledge about the internal structure and working of the system. It is commonly used in case of Integration testing.Load testing helps us to analyze the performance of the system under heavy load or under Zero load. This is achieved with the help of a Load Testing Tool. The intention for writing this research is to carry out a comparison of four load testing tools i.e. Apache JMeter, LoadRunner, Microsoft Visual Studio (TFS, Siege based on certain criteria  i.e. test scripts generation , result reports, application support, plug-in supports, and cost . The main focus is to study these load testing tools and identify which tool is better and more efficient . We assume this comparison can help in selecting the most appropriate tool and motivates the use of open source load testing tools.

  18. Loading Deformation Characteristic Simulation Study of Engineering Vehicle Refurbished Tire

    Science.gov (United States)

    Qiang, Wang; Xiaojie, Qi; Zhao, Yang; Yunlong, Wang; Guotian, Wang; Degang, Lv

    2018-05-01

    The paper constructed engineering vehicle refurbished tire computer geometry model, mechanics model, contact model, finite element analysis model, did simulation study on load-deformation property of engineering vehicle refurbished tire by comparing with that of the new and the same type tire, got load-deformation of engineering vehicle refurbished tire under the working condition of static state and ground contact. The analysis result shows that change rules of radial-direction deformation and side-direction deformation of engineering vehicle refurbished tire are close to that of the new tire, radial-direction and side-direction deformation value is a little less than that of the new tire. When air inflation pressure was certain, radial-direction deformation linear rule of engineer vehicle refurbished tire would increase with load adding, however, side-direction deformation showed linear change rule, when air inflation pressure was low; and it would show increase of non-linear change rule, when air inflation pressure was very high.

  19. Drift scale thermomechanical analysis for thermal loading and retrievability studies

    International Nuclear Information System (INIS)

    Tsai, F.C.

    1995-01-01

    The repository portion of the Mined Geologic Disposal System for the disposal of spent nuclear fuel and high-level radioactive waste is currently in the advanced conceptual design stage. In support of systems studies, a numerical method was used to estimate the stability of emplacement drifts. Thermomechanical analyses, using the Discontinuous Deformation Analysis code, were performed using input data from Yucca Mountain documents. The analysis found that the stresses produced in the rock at thermal loads of 27.4 kilograms uranium per m2 (KgU/m2) would exceed stability criteria and could result in tunnel instability. At thermal loads between 20.5 KgU/m2, the drift is predicted to be stable and its structural integrity remains after thermal loading. In this case, the smaller diameter drift emplacement appears to have better stability. However, local rock spalling may occur. According to the numerical prediction, more rock fall may occur during the retrieval period due to the stress relaxation caused by the rapid cooling in the immediate drift area

  20. Bulk Electric Load Cost Calculation Methods: Iraqi Network Comparative Study

    Directory of Open Access Journals (Sweden)

    Qais M. Alias

    2016-09-01

    Full Text Available It is vital in any industry to regain the spent capitals plus running costs and a margin of profits for the industry to flourish. The electricity industry is an everyday life touching industry which follows the same finance-economic strategy. Cost allocation is a major issue in all sectors of the electric industry, viz, generation, transmission and distribution. Generation and distribution service costing’s well documented in the literature, while the transmission share is still of need for research. In this work, the cost of supplying a bulk electric load connected to the EHV system is calculated. A sample basic lump-average method is used to provide a rough costing guide. Also, two transmission pricing methods are employed, namely, the postage-stamp and the load-flow based MW-distance methods to calculate transmission share in the total cost of each individual bulk load. The three costing methods results are then analyzed and compared for the 400kV Iraqi power grid considered for a case study.

  1. Human Rights and History Education: An Australian Study

    Science.gov (United States)

    Burridge Nina; Buchanan, John; Chodkiewicz, Andrew

    2014-01-01

    The place of education for and about human rights within the school curriculum remains contested and this paper reports on the first national cross-sectoral investigation of its place in Australian curricula and more specifically in national and state History curriculum documents. Opportunities for the inclusion of human rights based studies were…

  2. Website history and the website as an object of study

    DEFF Research Database (Denmark)

    Brügger, Niels

    2009-01-01

    This article puts on the agenda one of the fundamental theoretical questions within the emerging field of website history: how can the object of historical study — the website — be delimited? Its focus is on the 'website' artefact as a medium and a text. After elaborating a definition...

  3. Landmark Study Reveals Antarctic Glacier's Long History of Retreat

    OpenAIRE

    Kuska, Dale M.

    2016-01-01

    Faculty Showcase Archive Article Approved for public release; distribution is unlimited. A major study, released in late November in the journal “Nature,” reveals the history of retreat of the massive Pine Island Glacier (PIG) in western Antarctica, widely considered one of the largest contributors to global sea-level rise.

  4. A Study about Using Internet in History Lessons

    Science.gov (United States)

    Ulusoy, Kadir

    2012-01-01

    Internet has become an important part in the field of education as it is in every area nowadays as well. Internet has become appealing among educators and students with its easy and quick access and wide opportunities. In this study, an application of using internet in the history course was done. 160 students who were enrolled in College of…

  5. Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders

    NARCIS (Netherlands)

    Cichon, S.; Craddock, N.; Daly, M.J.; Faraone, S.V.; Gejman, P.V.; Kelsoe, J.; Lehner, T.; Levinson, D.F.; Moran, A.P.; Sklar, P.; Sullivan, P.F.; Boomsma, D.I.; de Geus, E.J.C.; Posthuma, D.; Willemsen, G.

    2009-01-01

    Objective: The authors conducted a review of the history and empirical basis of genomewide association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date, limitations, and plans for GWAS meta-analyses. Method: A literature review was carried out, power and other issues

  6. Genomewide association studies: history, rationale, and prospects for psychiatric disorders.

    NARCIS (Netherlands)

    Franke, B.; Buitelaar, J.K.; Cichon, S.; Craddock, N.; Daly, M.; Faraone, S.V.; Gejman, P.V.; Kelsoe, J.; Lehner, T.; Levinson, D.F.; Moran, A.; Sklar, P.; Sullivan, P.F.

    2009-01-01

    OBJECTIVE: The authors conducted a review of the history and empirical basis of genomewide association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date, limitations, and plans for GWAS meta-analyses. METHOD: A literature review was carried out, power and other issues

  7. Survival Rate of Dental Implants in Patients with History of Periodontal Disease: A Retrospective Cohort Study.

    Science.gov (United States)

    Correia, Francisco; Gouveia, Sónia; Felino, António Campos; Costa, Ana Lemos; Almeida, Ricardo Faria

    To evaluate the differences between the survival rates of implants placed in patients with no history of periodontal disease (NP) and in patients with a history of chronic periodontal disease (CP). A retrospective cohort study was conducted in which all consenting patients treated with dental implants in a private clinic in Oporto, Portugal, from November 2, 2002 through February 11, 2011 were included. All patients were treated consecutively by the same experimental operator. This study aimed to analyze how the primary outcomes (presence of disease, time of placement, and time of loading) and the secondary outcomes (severity-generalized periodontitis, brand, implant length, prosthesis type, prosthesis metal-ceramic extension) influence the survival rate of dental implants. The survival analysis was performed through the Kaplan-Meier method, and the equality of survival distributions for all groups was tested with the log-rank test with a significance level of .05 for all comparisons. The sample consisted of 202 patients (47% NP and 53% CP) and 689 implants (31% NP and 69% CP). The survival rate in the NP and CP groups showed no statistically significant differences (95.8% versus 93.1%; P ≥ .05). Implants were lost before loading in 54.9% of the cases. The majority of the implants were lost in the first year and stabilized after the second year. Survival rates in the NP and CP patients showed no statistically significant differences when comparing the following factors: subclassification of the disease, implant brands, implant length (short/standard), type of prosthesis, extension of the prosthesis metal-ceramic, and time of placement and loading (P ≥ .05). This work disclosed no statistically significant differences in terms of survival rates when compared with the control group. Placing implants in patients with a history of periodontal disease appears to be viable and safe.

  8. Field Study of Live Load Distribution Factors and Dynamic Load Allowance on Reinforced Concrete T-Beam Bridges

    National Research Council Canada - National Science Library

    Trimble, Matthew

    2003-01-01

    .... The vehicle under consideration in this study was a U.S. Army Palletized Loading System (PLS) military vehicle. Results from this evaluation were compared to those obtained from a civilian dump truck owned by the Virginia Department of Transportation...

  9. The Influence Of Load History On Durability Of P92 Steel Used For The Construction Of Energy Pipelines

    Directory of Open Access Journals (Sweden)

    Cieśla M.

    2015-09-01

    Full Text Available The research material used in the study was the martensitic creep-resistant steel P92 used for the manufacture of pipes being part of power generation units subject to heavy load. The research problem focused on two issues. The first one was to analyze how the plastic deformation cumulated in the material in low-cycle fatigue conditions affects the characteristics of the material in creep conditions in a temperature of 600ºC. The other one was concerned with analysis of a reverse situation, i.e. how the initial plastic deformation of the material in creep conditions changes the mechanical characteristics of the steel under low-cycle fatigue conditions in a temperature of 600ºC.

  10. Feasibility Study for Cobalt Bundle Loading to CANDU Reactor Core

    International Nuclear Information System (INIS)

    Park, Donghwan; Kim, Youngae; Kim, Sungmin

    2016-01-01

    CANDU units are generally used to produce cobalt-60 at Bruce and Point Lepreau in Canada and Embalse in Argentina. China has started production of cobalt-60 using its CANDU 6 Qinshan Phase III nuclear power plant in 2009. For cobalt-60 production, the reactor’s full complement of stainless steel adjusters is replaced with neutronically equivalent cobalt-59 adjusters, which are essentially invisible to reactor operation. With its very high neutron flux and optimized fuel burn-up, the CANDU has a very high cobalt-60 production rate in a relatively short time. This makes CANDU an excellent vehicle for bulk cobalt-60 production. Several studies have been performed to produce cobalt-60 using adjuster rod at Wolsong nuclear power plant. This study proposed new concept for producing cobalt-60 and performed the feasibility study. Bundle typed cobalt loading concept is proposed and evaluated the feasibility to fuel management without physics and system design change. The requirement to load cobalt bundle to the core was considered and several channels are nominated. The production of cobalt-60 source is very depend on the flux level and burnup directly. But the neutron absorption characteristic of cobalt bundle is too high, so optimizing design study is needed in the future

  11. Feasibility Study for Cobalt Bundle Loading to CANDU Reactor Core

    Energy Technology Data Exchange (ETDEWEB)

    Park, Donghwan; Kim, Youngae; Kim, Sungmin [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    CANDU units are generally used to produce cobalt-60 at Bruce and Point Lepreau in Canada and Embalse in Argentina. China has started production of cobalt-60 using its CANDU 6 Qinshan Phase III nuclear power plant in 2009. For cobalt-60 production, the reactor’s full complement of stainless steel adjusters is replaced with neutronically equivalent cobalt-59 adjusters, which are essentially invisible to reactor operation. With its very high neutron flux and optimized fuel burn-up, the CANDU has a very high cobalt-60 production rate in a relatively short time. This makes CANDU an excellent vehicle for bulk cobalt-60 production. Several studies have been performed to produce cobalt-60 using adjuster rod at Wolsong nuclear power plant. This study proposed new concept for producing cobalt-60 and performed the feasibility study. Bundle typed cobalt loading concept is proposed and evaluated the feasibility to fuel management without physics and system design change. The requirement to load cobalt bundle to the core was considered and several channels are nominated. The production of cobalt-60 source is very depend on the flux level and burnup directly. But the neutron absorption characteristic of cobalt bundle is too high, so optimizing design study is needed in the future.

  12. Study on Determination Method of Fatigue Testing Load for Wind Turbine Blade

    Science.gov (United States)

    Liao, Gaohua; Wu, Jianzhong

    2017-07-01

    In this paper, the load calculation method of the fatigue test was studied for the wind turbine blade under uniaxial loading. The characteristics of wind load and blade equivalent load were analyzed. The fatigue property and damage theory of blade material were studied. The fatigue load for 2MW blade was calculated by Bladed, and the stress calculated by ANSYS. Goodman modified exponential function S-N curve and linear cumulative damage rule were used to calculate the fatigue load of wind turbine blades. It lays the foundation for the design and experiment of wind turbine blade fatigue loading system.

  13. 2012 White Book, Pacific Northwest Loads and Resources Study

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-06

    The White Book is a planning analysis produced by BPA that informs BPA of its load and resource conditions for sales and purchases. The White Book provides a 10-year look at the expected obligations and resources in the Federal system and PNW region. The White Book is used as a planning tool for the Columbia River Treaty (Treaty) studies, as an information tool for customers and regional interests, and as a publication of information utilized by other planning entities for their analyses. The White Book is not used to guide day-to-day operations of the Federal Columbia River Power System (FCRPS) or determine BPA revenues or rates.

  14. On the Psychometric Study of Human Life History Strategies.

    Science.gov (United States)

    Richardson, George B; Sanning, Blair K; Lai, Mark H C; Copping, Lee T; Hardesty, Patrick H; Kruger, Daniel J

    2017-01-01

    This article attends to recent discussions of validity in psychometric research on human life history strategy (LHS), provides a constructive critique of the extant literature, and describes strategies for improving construct validity. To place the psychometric study of human LHS on more solid ground, our review indicates that researchers should (a) use approaches to psychometric modeling that are consistent with their philosophies of measurement, (b) confirm the dimensionality of life history indicators, and (c) establish measurement invariance for at least a subset of indicators. Because we see confirming the dimensionality of life history indicators as the next step toward placing the psychometrics of human LHS on more solid ground, we use nationally representative data and structural equation modeling to test the structure of middle adult life history indicators. We found statistically independent mating competition and Super-K dimensions and the effects of parental harshness and childhood unpredictability on Super-K were consistent with past research. However, childhood socioeconomic status had a moderate positive effect on mating competition and no effect on Super-K, while unpredictability did not predict mating competition. We conclude that human LHS is more complex than previously suggested-there does not seem to be a single dimension of human LHS among Western adults and the effects of environmental components seem to vary between mating competition and Super-K.

  15. On the Psychometric Study of Human Life History Strategies

    Directory of Open Access Journals (Sweden)

    George B. Richardson

    2017-02-01

    Full Text Available This article attends to recent discussions of validity in psychometric research on human life history strategy (LHS, provides a constructive critique of the extant literature, and describes strategies for improving construct validity. To place the psychometric study of human LHS on more solid ground, our review indicates that researchers should (a use approaches to psychometric modeling that are consistent with their philosophies of measurement, (b confirm the dimensionality of life history indicators, and (c establish measurement invariance for at least a subset of indicators. Because we see confirming the dimensionality of life history indicators as the next step toward placing the psychometrics of human LHS on more solid ground, we use nationally representative data and structural equation modeling to test the structure of middle adult life history indicators. We found statistically independent mating competition and Super-K dimensions and the effects of parental harshness and childhood unpredictability on Super-K were consistent with past research. However, childhood socioeconomic status had a moderate positive effect on mating competition and no effect on Super-K, while unpredictability did not predict mating competition. We conclude that human LHS is more complex than previously suggested—there does not seem to be a single dimension of human LHS among Western adults and the effects of environmental components seem to vary between mating competition and Super-K.

  16. Study on Mechanical Properties of Barite Concrete under Impact Load

    Science.gov (United States)

    Chen, Z. F.; Cheng, K.; Wu, D.; Gan, Y. C.; Tao, Q. W.

    2018-03-01

    In order to research the mechanical properties of Barite concrete under impact load, a group of concrete compression tests was carried out under the impact load by using the drop test machine. A high-speed camera was used to record the failure process of the specimen during the impact process. The test results show that:with the increase of drop height, the loading rate, the peak load, the strain under peak load, the strain rate and the dynamic increase factor (DIF) all increase gradually. The ultimate tensile strain is close to each other, and the time of impact force decreases significantly, showing significant strain rate effect.

  17. The Application of Load-cell Technique in the Study of Armour Unit Responses to Impact Loads Tests

    DEFF Research Database (Denmark)

    Burcharth, H. F.; Liu, Z.

    1995-01-01

    The slender, complex types of armour units, such as Tetrapods and Dolosse are widely used for rubble mound breakwaters. Many of the recent failures of such structures were caused by unforeseen early breakage of the units, thus revealing an in balance between the strength (structural integrity......) of the units and the hydraulic stability (resistance to displacements) of the armour layers. Breakage is caused by stresses from static, pulsating and impact loads. Impact load generated stresses are difficult to investigate due to non-linear scaling laws. The paper describes a method by which impact loads on....... slender armour units can be studied. by load-cell technique. Moreover, the paper presents DoJos design diagrams for the prediction of both breakage and hydraulic stability...

  18. Changes in water content in response to an acute bout of eccentric loading in a patellar tendon with a history of tendinopathy: A case report.

    Science.gov (United States)

    Ho, Kai-Yu; Kulig, Kornelia

    2016-10-01

    This case-based report assessed resting water content and exercise-driven water exchange within a tendon with a history of tendinopathy and compared the response to that of a healthy uninvolved tendon. Case Report. University imaging center. The participant was a 27-year-old female basketball player 39 months following knee trauma. Patellar tendinopathy developed 12 months after the injury episode and was treated with eccentric exercises. Eighteen months from the beginning of the first eccentric training bout, the participant reported full resolution of symptoms and returned to her pre-injury sport participation without symptoms. Eccentric decline squat exercise. Tendon water content obtained from magnetic resonance imaging (MRI). MRI acquired 39 months post-injury demonstrated increased resting water content of the involved tendon (involved: 91.1% vs. uninvolved: 84.6%). Immediately after the eccentric squat maneuver, water content decreased on both involved and uninvolved tendons (involved: 89.5% vs. uninvolved: 83.3%). Elevated resting water content of the involved tendon found in this report may be indicative of reduced tendon stiffness. A similar amount of water content reduction was observed on both sides following mechanical loading, suggesting that the involved tendon may respond to the eccentric exercise similarly to the uninvolved tendon. Future investigations are needed to study the relationships among tendon water exchanges, mechanical properties, patient symptoms, and tissue injuries.

  19. Studies in the History of Tax Law, Volume 6

    OpenAIRE

    Tiley, John

    2013-01-01

    These are the papers from the 2012 Cambridge Tax Law History Conference revised and reviewed for publication. The papers include new studies of: income tax law rewrite projects 1914–1956; law and administration in capital allowances 1878– 1950; the 'full amount' in income tax legislation; Sir Josiah Stamp and double income tax; early German income tax treaties and laws concerned with double tax avoidance (1869–1908); the policy of the medicine stamp duty; 'Danegeld' – from Danish tribute to E...

  20. A study on risk analysis for loading and un-loading accident

    International Nuclear Information System (INIS)

    Watabe, N.; Suzuki, H.; Saegusa, T.

    1998-01-01

    Low Level Waste packages are transported from each Japanese nuclear power plants to Rokkasho-Mura by exclusive ship. These packages are contained in half-height 5 ton containers. The handling system for loading and unloading containers is composed of the 25 ton crane, the cell-guide system and transport trucks. These systems are mostly automated and under computer control. By design, the whole handling system should be highly protected from any accident. However unknown causes for accidents might be concealed in this handling system, because of complicated system interaction between computer control and human operation. The representative 25 ton bridge type crane was analyzed in this assessment. As the first step, causes of drop accidents were analyzed using design drawing of the crane and its system operation flow chart as inputs to the analysis. After analysis the protection methods were reviewed, and where necessary, revised in each step accident cause. Those results were rearranged by fault trees for each cause. To provide quantitative details of operational interactions, crane operators and safety supervisors were consulted. Based on their experience, a method to determine probabilities of basic events was tentatively adopted. According to this assessment, each protection method was clarified and some weak points of the loading and un-loading process were able to be identified. Figure 1 shows schematically the sequential steps in the method. As a result of this assessment, the PSA method (including fault trees, etc) was found to be adaptable for the loading and un-loading process (i.e. handling system) and to be effective in understanding the system characteristics. Further, using this PSA analysis method allows transport companies to review protection methods with 'Cost and Benefit' analysis concepts. (authors)

  1. Engendering Curriculum History. Studies in Curriculum Theory Series

    Science.gov (United States)

    Hendry, Petra

    2011-01-01

    How can curriculum history be re-envisioned from a feminist, poststructuralist perspective? "Engendering Curriculum History" disrupts dominant notions of history as linear, as inevitable progress, and as embedded in the individual. This conversation requires a history that seeks "rememberance" not representation, "reflexivity" not linearity, and…

  2. Experiment and simulation study on unidirectional carbon fiber composite component under dynamic 3 point bending loading

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Guowei; Sun, Qingping; Zeng, Danielle; Li, Dayong; Su, Xuming

    2018-04-10

    In current work, unidirectional (UD) carbon fiber composite hatsection component with two different layups are studied under dynamic 3 point bending loading. The experiments are performed at various impact velocities, and the effects of impactor velocity and layup on acceleration histories are compared. A macro model is established with LS-Dyna for more detailed study. The simulation results show that the delamination plays an important role during dynamic 3 point bending test. Based on the analysis with high speed camera, the sidewall of hatsection shows significant buckling rather than failure. Without considering the delamination, current material model cannot capture the post failure phenomenon correctly. The sidewall delamination is modeled by assumption of larger failure strain together with slim parameters, and the simulation results of different impact velocities and layups match the experimental results reasonable well.

  3. Study of peak broadening effect in floor time histories

    International Nuclear Information System (INIS)

    Soni, R.S.; Kushwaha, H.S.; Mahajan, S.C.; Kakodkar, A.

    1996-01-01

    Seismic design of secondary systems such components and piping is usually carried out by using the floor motions at their support points. These floor motions can be in the form of Floor Response Spectra (FRS) or the Floor Time Histories (FTH). In order to account for the various uncertainties in generating these floor motions, these motions should be peak broadened and smoothened as per the regulatory codes. Presented here in this paper is the methodology to account for such peak broadening effect in the FTH. Results of this study have been compared with the FRS approach and various important conclusions have been arrived at based on the study

  4. Study on heat under dynamic loading of rubber

    Directory of Open Access Journals (Sweden)

    T. I. Igumenova

    2016-01-01

    Full Text Available A number of studies on heat buildup in tire rubber surface scan method samples using a thermal imaging camera. Investigated the exothermic chemical reaction mechanical destruction rubber when loading designs permanent cyclic stretching with deformation of the working zone 50%. Percentage of deformation of the working zone was chosen on the basis of the actual data on the stretch-compression zone "Rusk" tires, which is the maximum level difference of deformation during run-in. Experiment plan provided for periodic relaxation samples of at least 72 hours for more accurate simulation of operation process of structural products. Created and processed data on temperature changes in samples for bar and line profile for rubber compounds with the introduction of nanomodificator (fullerene-containing technical carbon in comparison with the control sample without him. The data obtained reflect the nature of heat depending on the composition of the compound. Identified common patterns of thermal nature of physicochemical process mechanical destruction rubbers. For rubber with nanomodifikatorom there has been an increase in the temperature interval reaction from a minimum to a maximum 2 degrees that is also linked to the rise in the average temperature of the reaction on the histogram also at 2-3 degrees of deformation under the same conditions and the level of cyclic loading. However, the temperature in the control sample that is associated with the beginning of the formation of hardened rubber structures, economies of Mallinza-Petrikeeva, occurs with delay twice compared with modified Fullerenes. Measurement of physic-mechanical indicators selected in the course of testing of samples showed the beginning of formation of structure with increased strength of samples in the sample temperature zone that corresponds to the thermal effect of èndotermičeskomu recombination reactions of macromolecules.

  5. Hallux valgus and plantar pressure loading: the Framingham foot study

    Science.gov (United States)

    2013-01-01

    Background Hallux valgus (HV), a common structural foot deformity, can cause foot pain and lead to limited mobility. The purpose of this study was to evaluate differences in plantar pressure and force during gait by HV status in a large population-based cohort of men and women. Methods A trained examiner performed a validated physical examination on participants’ feet and recorded the presence of hallux valgus and other specific foot disorders. Each foot was classified into one of four mutually exclusive groups based on the foot examination. Foot groups were: (i) HV only, (ii) HV and at least one additional foot disorder (FD), (iii) no HV but at least one other FD, and (iv) neither HV nor FD (referent). Biomechanical data for both feet were collected using Tekscan Matscan. Foot posture during quiet standing, using modified arch index (MAI), and foot function during gait, using center of pressure excursion index (CPEI), were calculated per foot. Further, walking scans were masked into eight sub-regions using Novel Automask, and peak pressure and maximum force exerted in each region were calculated. Results There were 3205 participants, contributing 6393 feet with complete foot exam data and valid biomechanical measurements. Participants with HV had lower hallucal loading and higher forces at lesser toes as well as higher MAI and lower CPEI values compared to the referent. Participants with HV and other FDs were also noted to have aberrant rearfoot forces and pressures. Conclusions These results suggest that HV alters foot loading patterns and pressure profiles. Future work should investigate how these changes affect the risk of other foot and lower extremity ailments. PMID:24138804

  6. A Relationship Study of Student Satisfaction with Learning Online and Cognitive Load: Initial Results

    Science.gov (United States)

    Bradford, George R.

    2011-01-01

    This study sought to explore if a relationship exists between cognitive load and student satisfaction with learning online. The study separates academic performance (a.k.a., "learning") from cognitive load and satisfaction to better distinguish influences on cognition (from cognitive load) and motivation (from satisfaction). Considerations that…

  7. Determination of post-shakedown quantities of a pipe bend via the simplified theory of plastic zones compared with load history dependent incremental analysis

    Science.gov (United States)

    Vollrath, Bastian; Hübel, Hartwig

    2018-01-01

    The Simplified Theory of Plastic Zones (STPZ) may be used to determine post-shakedown quantities such as strain ranges and accumulated strains at plastic or elastic shakedown. The principles of the method are summarized. Its practical applicability is shown by the example of a pipe bend subjected to constant internal pressure along with cyclic in-plane bending or/and cyclic radial temperature gradient. The results are compared with incremental analyses performed step-by-step throughout the entire load history until the state of plastic shakedown is achieved.

  8. Impact Study on Power Factor of Electrical Load in Power Distribution System

    International Nuclear Information System (INIS)

    Syirrazie Che Soh; Harzawardi Hasim; Ahmad Asraf, A.S.

    2014-01-01

    Low Power Factor of electrical loads cause high current is drawn from power supply. The impact of this circumstance is influenced by impedance of electrical load. Therefore, the key consideration of this study is how impedance of electrical loads influence power factor of electrical loads, and then power distribution as the whole. This study is important to evaluate the right action to mitigate low power factor effectively for electrical energy efficiency purpose. (author)

  9. Rett syndrome diagnostic criteria: lessons from the Natural History Study.

    Science.gov (United States)

    Percy, Alan K; Neul, Jeffrey L; Glaze, Daniel G; Motil, Kathleen J; Skinner, Steven A; Khwaja, Omar; Lee, Hye-Seung; Lane, Jane B; Barrish, Judy O; Annese, Fran; McNair, Lauren; Graham, Joy; Barnes, Katherine

    2010-12-01

    Analysis of 819 participants enrolled in the Rett syndrome (RTT) Natural History Study validates recently revised diagnostic criteria. 765 females fulfilled 2002 consensus criteria for classic (653/85.4%) or variant (112/14.6%) RTT. All participants classified as classic RTT fulfilled each revised main criterion; supportive criteria were not uniformly present. All variant RTT participants met at least 3 of 6 main criteria in the 2002, 2 of 4 main criteria in the current format, and 5 of 11 supportive criteria in both. This analysis underscores the critical role of main criteria for classic RTT; variant RTT requires both main and supportive criteria.

  10. Pathways from fertility history to later life health: Results from analyses of the English Longitudinal Study of Ageing

    Directory of Open Access Journals (Sweden)

    Emily Grundy

    2015-01-01

    Full Text Available Background: Previous research shows associations between fertility histories and later life health. The childless, those with large families, and those with a young age at entry to parenthood generally have higher mortality and worse health than parents of two or three children. These associations are hypothesised to reflect a range of biosocial influences, but underlying mechanisms are poorly understood. Objective: To identify pathways from fertility histories to later life health by examining mediation through health-related behaviours, social support and strain, and wealth. Additionally to examine mediation through allostatic load - an indicator of multisystem physical dysregulation, hypothesised to be an outcome of chronic stress. Methods: Associations between fertility histories, mediators, and outcomes were analysed using path models. Data were drawn from the English Longitudinal Study of Ageing. Outcomes studied were a measure of allostatic load based on 9 biomarkers and self-reported long-term illness which limited activities. Results: Early parenthood (Conclusions: In England early parenthood and larger family size are associated with less wealth and poorer health behaviours and this accounts for much of the association with health. At least part of this operates through stress-related physiological dysfunction (allostatic load.

  11. Study on load temperature control system of ground laser communication

    Science.gov (United States)

    Zhai, Xunhua; Zhang, Hongtao; Liu, Wangsheng; Zhang, Chijun; Zhou, Xun

    2007-12-01

    The ground laser communication terminal as the termination of a communication system, works at the temperature which varies from -40°C to 50°C. We design a temperature control system to keep optical and electronic components working properly in the load. The load is divided into two sections to control temperature respectively. Because the space is limited, we use heater film and thermoelectric cooler to clearify and refrigerate the load. We design a hardware and a software for the temperature control system, establish mathematic model, and emulate it with Matlab.

  12. Fracture studies on stainless steel straight pipes under earthquake-type cyclic loading

    International Nuclear Information System (INIS)

    Raghava, G.; Vishnuvardhan, S.; Gandhi, P.; Vaze, K.K.

    2014-01-01

    In order to study the crack growth and cyclic fracture behaviour, which are required for realistic assessment of Leak Before Break (LBB) applicability, experimental investigations were carried out on straight pipes under quasi-crystal loading. Totally 13 pipes were tested; three were stainless steel welded (SSW) using conventional shielded metal arc welding (SMAW) technique and the remaining specimens were Narrow Gap Welded (NGW). The fracture tests were carried out under load control, displacement control and combination of the two; the pipes were subjected to different amplitudes of load or load-line displacement (LLD), which were decided based on the response of the pipes under monotonic loading. Cyclic tearing and crack growth studies on eight straight pipes of the same material reported earlier in published literature are also considered for studying the results and understanding the behaviour. Under load control, with almost equal load amplitude, the NGW pipe exhibited improved life in comparison with SMAW pipe when both are subjected to cyclic loading. The crack growth and tearing instability behaviour of the pipes were studied. The same were found to be different for load control, displacement control and combined control tests. Based in the load-controlled experimental results, material specific plot between cyclic load amplitude (as a percentage of maximum load carrying capacity of a specimen under monotonic fracture) and number of cycles to failure was obtained. The results indicate that the piping components subjected to quasi-cyclic loading may fail in very less number of cycles even when the load amplitude is sufficiently below the monotonic fracture/collapse load. These studies will be helpful in designing nuclear power plant (NPP) piping components subjected to earthquake-type cyclic loading. (author)

  13. A study of cognitive loading in dual-coding theory.

    Science.gov (United States)

    Ishi, H; Yamauchi, H

    1994-08-01

    15 university students were engaged in a task of recalling sentences with and without figures. Analysis of the number recalled indicated that cognitive loading for sentences with figures was more effective than for recall of sentences without figures.

  14. Cognitive Load Theory: An Empirical Study of Anxiety and Task Performance in Language Learning

    Science.gov (United States)

    Chen, I-Jung; Chang, Chi-Cheng

    2009-01-01

    Introduction: This study explores the relationship among three variables--cognitive load, foreign language anxiety, and task performance. Cognitive load refers to the load imposed on working memory while performing a particular task. The authors hypothesized that anxiety consumes the resources of working memory, leaving less capacity for cognitive…

  15. Reduced phrenic motoneuron recruitment during sustained inspiratory threshold loading compared to single-breath loading: a twitch interpolation study

    Directory of Open Access Journals (Sweden)

    Mathieu Raux

    2016-11-01

    Full Text Available In humans, inspiratory constraints engage cortical networks involving the supplementary motor area. Functional magnetic resonance imaging (fMRI shows that the spread and intensity of the corresponding respiratory-related cortical activation dramatically decrease when a discrete load becomes sustained. This has been interpreted as reflecting motor cortical reorganisation and automatisation, but could proceed from sensory and/or affective habituation. To corroborate the existence of motor reorganisation between single-breath and sustained inspiratory loading (namely changes in motor neurones recruitment, we conducted a diaphragm twitch interpolation study based on the hypothesis that motor reorganisation should result in changes in the twitch interpolation slope. Fourteen healthy subjects (age: 21 – 40 years were studied. Bilateral phrenic stimulation was delivered at rest, upon prepared and targeted voluntary inspiratory efforts (vol, upon unprepared inspiratory efforts against a single-breath inspiratory threshold load (single-breath, and upon sustained inspiratory efforts against the same type of load (continuous. The slope of the relationship between diaphragm twitch transdiaphragmatic pressure and the underlying transdiaphragmatic pressure was –1.1 ± 0.2 during vol, –1.5 ± 0.7 during single-breath, and -0.6 ± 0.4 during continuous (all slopes expressed in percent of baseline.percent of baseline-1 all comparisons significant at the 5% level. The contribution of the diaphragm to inspiration, as assessed by the gastric pressure to transdiaphragmatic pressure ratio, was 31 ± 17 % during vol, 22 ± 16 % during single-breath (p=0.13, and 19 ± 9 % during continuous (p = 0.0015 vs. vol. This study shows that the relationship between the amplitude of the transdiaphragmatic pressure produced by a diaphragm twitch and its counterpart produced by the underlying diaphragm contraction is not unequivocal. If twitch interpolation is interpreted as

  16. Australian football players' Achilles tendons respond to game loads within 2 days: an ultrasound tissue characterisation (UTC) study.

    Science.gov (United States)

    Rosengarten, Samuel D; Cook, Jill L; Bryant, Adam L; Cordy, Justin T; Daffy, John; Docking, Sean I

    2015-02-01

    The Achilles tendon is a tissue that responds to mechanical loads at a molecular and cellular level. In vitro and in vivo studies have shown that the expression of anabolic and/or catabolic proteins can change within hours of loading and return to baseline levels within 72 h. These biochemical changes have not been correlated with changes in whole tendon structure on imaging. We examined the nature and temporal sequence of changes in Achilles tendon structure in response to competitive game loads in elite Australian football players. Elite male Australian football players with no history of Achilles tendinopathy were recruited. Achilles tendon structure was quantified using ultrasound tissue characterisation (UTC) imaging, a valid and reliable measure of intratendinous structure, the day prior to the match (day 0), and then reimaged on days 1, 2 and 4 postgame. Of the 18 participants eligible for this study, 12 had no history of tendinopathy (NORM) and 6 had a history of patellar or hamstring tendinopathy (TEN). Differences in baseline UTC echopattern were observed between the NORM and TEN groups, with the Achilles of the TEN group exhibiting altered UTC echopattern, consistent with a slightly disorganised tendon structure. In the NORM group, a significant reduction in echo-type I (normal tendon structure) was seen on day 2 (p=0.012) that returned to baseline on day 4. There was a transient change in UTC echopattern in the Achilles tendon as a result of an Australian football game in individuals without a history of lower limb tendinopathy. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. Study on simplified estimation of J-integral under thermal loading

    International Nuclear Information System (INIS)

    Takahashi, Y.

    1993-01-01

    For assessing structural integrity or safety of nuclear power plants, strength of structures under the presence of flaws sometimes needs to be evaluated. Because relative large inelastic deformation is anticipated in the liquid metal reactor components even without flaws due to high operating temperature and large temperature gradients, inelastic effects should be properly taken into account in the flaw assessment procedures. It is widely recognized that J-integral and its variations - e.g. fatigue J-integral range and creep J-integral - play substantial roles in the flaw assessment under the presence of large inelastic deformation. Therefore their utilization has been promoted in the recent flaw assessment procedure both for low and high temperature plants. However, it is not very practical to conduct a detailed numerical computation for cracked structures to estimate the values of these parameters for the purpose of trailing crack growth history. Thus development of simplified estimation methods which do not require full numerical calculation for cracked structures is desirable. A method using normalized J-integral solutions tabulated in the handbook is a direct extension of linear fracture mechanics counterpart and it can be used for standard specimen and simple structural configurations subjected to specified loading type. The reference stress method has also been developed but in this case limit load solutions, which are often difficult to obtain for general stress distribution, are necessary instead of nonlinear J-integral solutions. However, both methods have been developed mainly for mechanical loading and thus applying these techniques to thermal stress problem is rather difficult except the cases where the thermal stress can be properly substituted by equivalent mechanical loading as in the case of simple thermal expansion loading. Therefore alternative approach should be pursued for estimating J-integral and their variations in thermal stress problems

  18. Thermal loading studies using cooling enhancement and ventilation

    International Nuclear Information System (INIS)

    Danko, G.

    1993-01-01

    Thermal loading studies are presented for short vertical emplacement, application of cooling enhancement, and drift ventilation. Two 25-m-long heat pipes upward oriented at 45 deg are installed at each emplacement borehole to promote heat transport into the pillar area. In addition, ventilation of the emplacement drifts is assumed for a 2- to 20-yr period. It is concluded that the maximum borehole temperature can be reduced from 230 to 136 C using only the heat pipes, and to 110 C applying the heat pipes together with moderate air cooling. The ventilation along without heat pipes can reduce the temperature to only ∼200 C. It is also demonstrated that the heat transferred from the container area to farther distances into the pillar raises rock temperatures significantly, by 10 to 20 C, and the increase in temperature remains noticeable for at least 1,000 yr. In addition, because of the more efficient heat distribution caused by the heat pipes, lower temperatures will be achieved in the container area together with improved drying and permanent as well as temporary water removal in the pillar area

  19. Social Relationships and Allostatic Load in the MIDUS Study

    Science.gov (United States)

    Brooks, Kathryn P.; Gruenwald, Tara; Karlamanga, Arun; Hu, Peifung; Koretz, Brandon; Seeman, Teresa E.

    2014-01-01

    OBJECTIVE This study examines how the social environment is related to allostatic load (AL), a multi-system index of biological risk. METHODS A national sample of adults (N = 949) aged 34-84 rated their relationships with spouse, family, and friends at two time points 10 years apart. At the second time point, participants completed a biological protocol in which indices of autonomic, hypothalamic-pituitary-adrenal axis, cardiovascular, inflammatory, and metabolic function were obtained and used to create an AL summary score. Generalized estimating equations were used to examine the associations among three aspects of social relationships – social support, social negativity, and frequency of social contact – and AL. RESULTS Higher levels of spouse negativity, family negativity, friend contact, and network level contact were each associated with higher AL, and higher levels of spouse support were associated with lower AL, independent of age, sociodemographic factors, and health covariates. Tests for age interactions suggested that friend support and network support were each associated with higher AL among older adults, but at younger ages there appeared to be no association between friend support and AL and a negative association between network support and AL. For network negativity, there was a marginal interaction such that network negativity was associated with higher AL among younger adults but there was no association among older adults. CONCLUSIONS These findings demonstrate that structural and functional aspects of the social environment are associated with AL, and extend previous work by demonstrating that these associations vary based on the type of relationship assessed and by age. PMID:24447186

  20. Feasibility Study of RFID Technology for Construction Load Tracking

    Science.gov (United States)

    2011-12-31

    RFID technology was proven to be successful in tracking dump trucks from loading plant to a paver location on a highway project. The average roundtrip time was 1 hour and 4 minutes. However, 3% of this data has truck delivery times in excess of 2 hou...

  1. Study on ant colony optimization for fuel loading pattern problem

    International Nuclear Information System (INIS)

    Kishi, Hironori; Kitada, Takanori

    2013-01-01

    Modified ant colony optimization (ACO) was applied to the in-core fuel loading pattern (LP) optimization problem to minimize the power peaking factor (PPF) in the modeled 1/4 symmetry PWR core. Loading order was found to be important in ACO. Three different loading orders with and without the adjacent effect between fuel assemblies (FAs) were compared, and it was found that the loading order from the central core is preferable because many selections of FAs to be inserted are available in the core center region. LPs were determined from pheromone trail and heuristic information, which is a priori knowledge based on the feature of the problem. Three types of heuristic information were compared to obtain the desirable performance of searching LPs with low PPF. Moreover, mutation operation, such as the genetic algorithm (GA), was introduced into the ACO algorithm to avoid searching similar LPs because heuristic information used in ACO tends to localize the searching space in the LP problem. The performance of ACO with some improvement was compared with those of simulated annealing and GA. In conclusion, good performance can be achieved by setting proper heuristic information and mutation operation parameter in ACO. (author)

  2. Moving Toward a Humanistic Social Studies and History Curricula

    Directory of Open Access Journals (Sweden)

    Christopher Berg

    2014-03-01

    Full Text Available Current reflective practices in the social studies are examined in light of how these strategies can add value and meaning to social studies curriculums. Many of these reflective practices were introduced within teacher education programs’ social studies methods courses, to expose pre-service teachers to innovative teaching practices that could be used in the classroom. An ineffective textbook-centered curriculum has dominated education in the United States for over a century. The researchers in this article argue for a new, reflective approach to teaching history and social studies curricula. New pedagogical models are needed to revive an ailing social studies program in the public school system. This article includes a selective examination of some traditional and non-traditional methods for promoting student learning and growth through reflective practices. Those considered in this article include dialogue journals, textbooks, culturally responsive texts (CRT, the Persona Doll Project, mask-making, primary source documents, and co-teaching. Each reflective practice strategy has its merits and could be easily implemented to improve pedagogical practice.

  3. 1991 Pacific Northwest loads and resources study, Pacific Northwest economic and electricity use forecast

    International Nuclear Information System (INIS)

    1992-01-01

    This publication provides detailed documentation of the load forecast scenarios and assumptions used in preparing BPA's 1991 Pacific Northwest Loads and Resources Study (the Study). This is one of two technical appendices to the Study; the other appendix details the utility-specific loads and resources used in the Study. The load forecasts and assumption were developed jointly by Bonneville Power Administration (BPA) and Northwest Power Planning Council (Council) staff. This forecast is also used in the Council's 1991 Northwest Conservation and Electric Power Plan (1991 Plan)

  4. 1991 Pacific Northwest Loads and Resources Study, Technical Appendix: Volume 1.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-03-01

    This publication provides detailed documentation of the load forecast scenarios and assumptions used in preparing BPA's 1991 Pacific Northwest Loads and Resources Study (the Study). This is one of two technical appendices to the Study; the other appendix details the utility-specific loads and resources used in the Study. The load forecasts and assumption were developed jointly by Bonneville Power Administration (BPA) and Northwest Power Planning Council (Council) staff. This forecast is also used in the Council's 1991 Northwest Conservation and Electric Power Plan (1991 Plan).

  5. Development of a mechanical testing and loading system for trabecular bone studies for long term culture

    Directory of Open Access Journals (Sweden)

    DB Jones

    2003-03-01

    Full Text Available A highly accurate (�3% mechanical loading and measurement system combined with a trabecular bone diffusion culture-loading chamber has been developed, which provides the ability to study trabecular bone (and possibly cartilage under controlled culture and loading conditions over long periods of time. The loading device has been designed to work in two main modes, either to apply a specific compressive strain to a trabecular bone cylinder or to apply a specific force and measure the resulting deformation. Presently, precisely machined bone cylinders can be loaded at frequencies between 0.1 Hz to 50 Hz and amplitudes over 7,000�e. The system allows accurate measurement of many mechanical properties of the tissue in real time, including visco-elastic properties. This paper describes the technical components, reproducibility, precision, and the calibration procedures of the loading system. Data on long term culture and mechanical responses to different loading patterns will be published separately.

  6. Historians or History Teachers? A Qualitative Study in Pedagogical Formation Program in Turkey

    Science.gov (United States)

    Ünisen, Ali

    2016-01-01

    This study aims to determine how the history teaching career is perceived by prospective history teachers who attended the pedagogical formation program in Adiyaman University in 2014-2015 academic year. The study was conducted through content analysis of 5 sets of essays dealing with various aspects of history teaching. The essays topics were…

  7. From the History of Religions to the Study of Religion in Denmark

    DEFF Research Database (Denmark)

    Jensen, Tim; Geertz, Armin W.

    2014-01-01

    The history of the academic study of religion in Denmark resembles developments in other Nordic and European countries as it has moved from a primarily historical-philological and comparative ‘history of religions’ towards a broader ‘study of religion(s)’ that includes history of religions together...

  8. Experimental studies of yield phenomena in biaxially loaded metals

    International Nuclear Information System (INIS)

    Hecker, S.S.

    1976-01-01

    Realistic materials properties input represents one of the major limitations in computer stress analysis in the plastic range. Lack of data on the response of many structural materials to multiaxial loading requires modeling plastic behavior. Such models can at best predict the response of a limited class of materials for a limited range of loading. A summary of biaxial plasticity experiments on metals is presented to provide a testing ground for such models and to serve as a reference guide for materials that may be of practical interest. Most of the work has been done on materials assumed to exhibit time-and-pressure-independent plastic flow. Special attention is focused on initial and subsequent yield conditions and stress-strain relations. Some specific examples of material behavior that does not fall within the assumptions of classical plasticity theories are discussed. These include time-dependence as evidenced in creep, cyclic loading and strain-rate effects, pressure dependence, large strain behavior, microstructural changes and failure laws. 15 figures, 277 references

  9. High strain fatigue behaviour of a high-temperature, low-alloyed forging steel subject to a servicelike loading history

    International Nuclear Information System (INIS)

    Kloos, K.H.; Granacher, J.; Rieth, P.

    1979-01-01

    A test plan was developed for selected cases of service-like long-time high strain load of a heated surface of massive components, which includes service-like anisothermic high strain tests with pressure-strain in the start-up phase and pull-strain in the shutdown phase, comparable isothermal tests at the highest cycle temperature, and finally tests with 'packaged' high strain and creep strain periods, which should enable long-time-tests with only short use of the large-scale high-strain-test-technique. The tests started on the melts of the high-temperature steel 28 Cr Mo NiV 4 9 have reached a longest tests time of nearly 1000 at a maximum temperature of 525 0 C. On the basis of there results, the carrying-out of 'packaged' long-time high strain tests with short creep strain periods seem to be a good way of determining the long-time high-strain behaviour of this steel under service-like strain cycles. (orig./RW) 891 RW/orig.- 892 RKD [de

  10. Fine Arts as Means for Studying Media History

    Directory of Open Access Journals (Sweden)

    Tereza Ježková

    2015-09-01

    Full Text Available Studying art as a manifestation of cultural memory can help us understand both collective and individual identities. Specific works of art can give us a sense of the artist while the content can also present a more general theme or social issue of a given era. Considering the number of artworks that reference (either as a major or minor topical element mass communication, media seems to be a feasible theme. The topic of media and its specific appearances has varied significantly throughout the history of both art and media. The aim of this paper is to introduce a unique analysis that combines artworks that display the use of mass communication in Czech fine arts. The collected items were the subject of an interdisciplinary analysis – both historical and semiotic. So far, the relationship between media and art has not been explored within Czech media studies. Finding the connection between fine arts and the media can broaden the horizons of historical and social sciences. Representation of media by art points to the importance of media in any given historical period. Some examples can clearly show us how media were produced and consumed, as well as, in the later periods, used as a material for the creation or the art itself. The objective of this paper is to show the perspectives and limits of art as a source of knowledge about cultural memory and advantages and disadvantages of combining historical and semiotic analyses as applied to specific artworks.

  11. A history of studies on safety of irradiated foods

    International Nuclear Information System (INIS)

    Miyahara, Makoto

    2003-01-01

    This report explained a history of studies on safety of irradiated foods in the United States. The army of USA had begun an experiment of irradiated foods in 1953. The toxic tests consisted of three phase, the phase I (1954 to 1959), phase II (1956 to 1965) and phase III (1971 to 1978). In the phase I, the short period toxic tests (90days) of 54 kinds of foods were carried out using high and low irradiation. The Swift and Company Laboratories reported detailed animal tests of 2685 albino rat, chickens and human. The animal tests showed many kinds of nutrition disorder, but the human test no problem. On phase II, 22 kinds of foods were tested for long period using rat, dog and mouse. Dog showed many kinds of symptom, for example, low birthrate, short life time, low growth rate, increasing spleen weight and thyroid disease. On phase III, two companies carried out the toxic test and Ralston Purina Company report is only data to be used now. Atomic Energy Commission (AEC) (1960 to 1970), Department of Commerce (1965 to 1976) and Department of Agriculture (1961 to 1966) studied safety of irradiated foods. Food and Drug Administration (FDA) determined that the irradiated foods belonged to under the category of food additive in 1958. FDA tests safety of irradiated foods using the determination tree and permitted many kinds of irradiated foods. (S.Y.)

  12. Effect of the hydro-thermal load history on the high-temperature creep of HTR-concrete

    International Nuclear Information System (INIS)

    Diederichs, U.; Rostasy, F.S.; Becker, G.

    1991-01-01

    In the research and development works for the prestressed concrete vessel for the HTR-500 high temperature reactor, the comprehensive tests concerning mix design, manufacture as well as mechanical and thermal behavior of the concrete have been carried out. The concrete was put to the numerous tests for determining the strength and the creep behavior at elevated temperature. In the real PCRV, the concrete is heated at different heating rate depending on the location of a certain volume element of the concrete in the structure. Furthermore, the heat transport simultaneously causes the moisture transport. For this reason, the test has been planned to investigate the transient creep at various heating rates and in different states of moisture during heating to the accident temperature up to 300 deg C. The cylindrical specimens were used for the high temperature creep test. The test procedure and the test results are reported. It was shown that the thermal history (heating rate, duration of holding at a certain temperature and so on) determines the transient creep deformation to a great extent. (K.I.)

  13. How to study the history of European law?

    DEFF Research Database (Denmark)

    Rasmussen, Morten

    This paper has a double purpose. On the one hand, it offers a new history, based on recently discovered primary sources, of the driving forces behind the so-called ‘constitutionalisation’ of European law taking place in 1963-64. On the other hand, it uses the lessons of this new history to reflect...... on how a general history of European law should be written and in particular how to avoid the pitfalls that characterises mainstream research on European law. In the first part it is argued that the ‘constitutionalisation’ of European law was promoted by a broad coalition beyond the Court of Justice...... the ‘constitutionalisation’ of European law in the 1960s. This is in particular the case with the ‘integration-through-law’ paradigm that permeates most of the writing on European law even today. Concluding, it is argued that a general history of European law should avoid the adoption of mainstream conceptualisations...

  14. Working memory load modulates the neural response to other's pain: Evidence from an ERP study.

    Science.gov (United States)

    Cui, Fang; Zhu, Xiangru; Luo, Yuejia; Cheng, Jiaping

    2017-03-22

    The present study investigated the time course of processing other's pain under different conditions of working memory (WM) load. Event-related potentials (ERPs) were recorded while the participants held two digits (low WM load) or six digits (high WM load) in WM and viewed pictures that showed others who were in painful or non-painful situations. Robust WM-load×Picture interactions were found for the N2 and LPP components. In the high WM-load condition, painful pictures elicited significantly larger amplitudes than non-painful pictures. In the low WM load condition, the difference between the painful and non-painful pictures was not significant. These ERP results indicate that WM load can influence both the early automatic N2 component and late cognitive LPP component. Compared with high WM load, low WM load reduced affective arousal and emotional sharing in response to other's pain and weakened the cognitive evaluation of task irrelevant stimuli. These findings are explained from the load theory perspective. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Study of load balancing technology for EAST data management

    Energy Technology Data Exchange (ETDEWEB)

    Li, Shi, E-mail: lishi@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui (China); Wang, Feng [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui (China); Xiao, Bingjia [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui (China); School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui (China); Yang, Fei [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui (China); Department of Computer Science, Anhui Medical University, Hefei, Anhui (China); Sun, Xiaoyang; Wang, Yong [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui (China)

    2014-05-15

    Highlights: • The load balancing concept is introduced into the MDSplus data service. • The new data service system based on the LVS framework and heartbeat technologies are described. • The scheduling algorithm “WLC” is used, and a software system is developed for optimizing the weight of node server. - Abstract: With the continuous renewal and increasing number of diagnostics, the EAST tokamak routinely generates ∼3 GB of raw data per pulse of the experiment, which is transferred to a centralized data management system. In order to strengthen international cooperation, all the acquired data has been converted and stored in the MDSplus servers. During the data system operation, there are some problems when a lot of client machines connect to a single MDSplus data server. Because the server process keeps the connection until the client closes its connection, a lot of server processes use a lot of network ports and consume a large amount of memory, so that the speed of access to data is very slow, but the CPU resource is not fully utilized. To improve data management system performance, many MDSplus servers will be installed on the blade server and form a server cluster to realize load balancing and high availability by using LVS and heartbeat technology. This paper will describe the details of the design and the test results.

  16. Macrocrack propagation in concrete specimens under sustained loading: Study of the physical mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Pierre, E-mail: pierre.rossi@lcpc.fr; Boulay, Claude; Tailhan, Jean-Louis; Martin, Eric; Desnoyers, Dominic

    2014-09-15

    This study presents a series of 4-point bending tests performed to describe the delayed behavior of unreinforced pre-cracked beams under low, moderate and high sustained loading levels. The deflection creep rate, the failure time and the load level were assessed. A linear relation, in a semi-log scale, was found for the deflection creep rate at high load levels. In addition, a linear relation, in a log–log scale, between the secondary deflection creep rate and failure time was observed. Besides, it was shown that the secondary creep deflection rate increases with the sustained loading level and the macrocrack propagation rate when macrocrack propagation occurs during the sustained loading. Physical mechanisms are proposed to explain these results and may be summarized as follows: the delayed behavior of an unreinforced cracked concrete specimen under sustained loading is mainly due to the cracking evolution, thus the creation of microcracks and/or the propagation of a macrocrack.

  17. Study on the Flare Load Estimation of the Deethanizer using Dynamic Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyungtae; Won, Wangyun [GS EC, Seoul (Korea, Republic of); Shin, Dongil [Myongji University, Yongin (Korea, Republic of)

    2014-10-15

    A flare system is a very important system that crucially affects on the process safety in chemical plants. If a flare system is designed too small, it cannot prevent catastrophic accidents of a chemical plant. On the other hand, if a flare system is designed too large, it will waste resources. Therefore, reasonable relief load estimation has been a crucial issue in the industry. American Petroleum Institute (API) suggests basic guidelines for relief load estimation, and a lot of engineering companies have developed their own relief load estimation methods that use an unbalanced heat and material method. However, these methods have to involve lots of conservative assumptions that lead to an overestimation of relief loads. In this study, the new design procedure for a flare system based on dynamic simulation was proposed in order to avoid the overestimation of relief loads. The relief load of a deethanizer process was tested to verify the performance of the proposed design procedure.

  18. Macrocrack propagation in concrete specimens under sustained loading: Study of the physical mechanisms

    International Nuclear Information System (INIS)

    Rossi, Pierre; Boulay, Claude; Tailhan, Jean-Louis; Martin, Eric; Desnoyers, Dominic

    2014-01-01

    This study presents a series of 4-point bending tests performed to describe the delayed behavior of unreinforced pre-cracked beams under low, moderate and high sustained loading levels. The deflection creep rate, the failure time and the load level were assessed. A linear relation, in a semi-log scale, was found for the deflection creep rate at high load levels. In addition, a linear relation, in a log–log scale, between the secondary deflection creep rate and failure time was observed. Besides, it was shown that the secondary creep deflection rate increases with the sustained loading level and the macrocrack propagation rate when macrocrack propagation occurs during the sustained loading. Physical mechanisms are proposed to explain these results and may be summarized as follows: the delayed behavior of an unreinforced cracked concrete specimen under sustained loading is mainly due to the cracking evolution, thus the creation of microcracks and/or the propagation of a macrocrack

  19. Citizenship Education about War and Peace: A Study of the History of the Vietnam War through Oral History

    Science.gov (United States)

    Murray, Thomas E.

    2004-01-01

    In this article, the author discusses his "History of the Vietnam War" course, which takes oral history as the core of its curriculum. This oral history focuses on personal lives and stories that can bring history to life. The components of the course are as follows: (1) overview of the History of the Vietnam War; (2) email interviews;…

  20. Study protocol: a mixed methods feasibility study for a loaded self-managed exercise programme for patellofemoral pain.

    Science.gov (United States)

    Smith, Benjamin E; Hendrick, Paul; Bateman, Marcus; Moffatt, Fiona; Rathleff, Michael Skovdal; Selfe, James; Smith, Toby O; Logan, Pip

    2018-01-01

    Patellofemoral pain (PFP) is one of the most common forms of knee pain in adults under the age of 40, with a prevalence of 23% in the general population. The long-term prognosis is poor, with only one third of people pain-free 1 year after diagnosis. The biomedical model of pain in relation to persistent PFP has recently been called into question. It has been suggested that interventions for chronic musculoskeletal conditions should consider alternative mechanisms of action, beyond muscles and joints. Modern treatment therapies should consider desensitising strategies, with exercises that target movements and activities patients find fearful and painful. High-quality research on exercise prescription in relation to pain mechanisms, not directed at specific tissue pathology, and dose response clearly warrants further investigation. Our primary aim is to establish the feasibility and acceptability of conducting a definitive RCT which will evaluate the clinical and cost-effectiveness of a loaded self-managed exercise programme for people with patellofemoral pain. This is a single-centred, multiphase, sequential, mixed-methods trial that will evaluate the feasibility of running a definitive large-scale randomised controlled trial of a loaded self-managed exercise programme versus usual physiotherapy. Initially, 8-10 participants with a minimum 3-month history of PFP will be recruited from an NHS physiotherapy waiting list and interviewed. Participants will be invited to discuss perceived barriers and facilitators to exercise engagement, and the meaning and impact of PFP. Then, 60 participants will be recruited in the same manner for the main phase of the feasibility trial. A web-based service will randomise patients to a loaded self-managed exercise programme or usual physiotherapy. The loaded self-managed exercise programme is aimed at addressing lower limb knee and hip weakness and is positioned within a framework of reducing fear/avoidance with an emphasis on self

  1. A computational parametric study on edge loading in ceramic-on-ceramic total hip joint replacements.

    Science.gov (United States)

    Liu, Feng; Feng, Li; Wang, Junyuan

    2018-07-01

    Edge loading in ceramic-on-ceramic total hip joint replacement is an adverse condition that occurs as the result of a direct contact between the head and the cup rim. It has been associated with translational mismatch in the centres of rotation of the cup and head, and found to cause severe wear and early failure of the implants. Edge loading has been considered in particular in relation to dynamic separation of the cup and head centres during a gait cycle. Research has been carried out both experimentally and computationally to understand the mechanism including the influence of bearing component positioning on the occurrence and severity of edge loading. However, it is experimentally difficult to measure both the load magnitude and duration of edge loading as it occurs as a short impact within the tight space of hip joints. Computationally, a dynamic contact model, for example, developed using the MSC ADAMS software for a multi-body dynamics simulation can be particularly useful for calculating the loads and characterising the edge loading. The aim of the present study was to further develop the computational model, and improve the predictions of contact force and the understanding of mechanism in order to provide guidance on design and surgical factors to avoid or to reduce edge loading and wear. The results have shown that edge loading can be avoided for a low range of translational mismatch in the centres of rotation of the cup and head during gait at the level of approximately 1.0 mm for a cup at 45° inclination, keeping a correct cup inclination at 45° is important to reduce the edge loading severity, and edge loading can be avoided for a certain range of translational mismatch of the cup and head centres with an increased swing phase load. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. Human genetic studies in areas of high natural radiation VI. Genetical load and ethnic group

    Energy Technology Data Exchange (ETDEWEB)

    Freire-Maia, A [Faculdade de Ciencias Medicas e Biologicas de Botucatu (Brazil). Departamento de Genetica

    1974-01-01

    The load of mutations disclosed by inbreeding, according to the ethnic group of the parents, has been analyzed in our data. Besides the total of the population, a sample with no alien ancestrals has also been analyzed. Genetic load has been studied for absortions, still births, pos-natal mortality, total mortality, anomalies, total mortality + anomalies, and abnormalities in general.

  3. 1993 Pacific Northwest Loads and Resources Study, Technical Appendix: Volume 2, Book 1, Energy.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1993-12-01

    The 1993 Pacific Northwest Loads and Resources Study establishes the Bonneville Power Administration`s (BPA) planning basis for supplying electricity to BPA customers. The Loads and Resources Study is presented in three documents: (1) this technical appendix detailing loads and resources for each major Pacific and Northwest generating utility, (2) a summary of Federal system and Pacific Northwest region loads and resources, and (3) a technical appendix detailing forecasted Pacific Northwest economic trends and loads. This analysis updates the 1992 Pacific Northwest Loads and Resources Study Technical Appendix published in December 1992. This technical appendix provides utility-specific information that BPA uses in its long-range planning. It incorporates the following for each utility (1) Electrical demand firm loads; (2) Generating resources; and (3) Contracts both inside and outside the region. This document should be used in combination with the 1993 Pacific Northwest Loads and Resources Study, published in December 1993, because much of the information in that document is not duplicated here.

  4. Human genetic studies in areas of high natural radiation VI. Genetical load and ethnic group

    International Nuclear Information System (INIS)

    Freire-Maia, A.

    1974-01-01

    The load of mutations disclosed by inbreeding, according to the ethnic group of the parents, has been analyzed in our data. Besides the total of the population, a sample with no alien ancestrals has also been analyzed. Genetic load has been studied for absortions, still births, pos-natal mortality, total mortality, anomalies, total mortality + anomalies, and abnormalities in general [pt

  5. In Situ Test Study of Characteristics of Coal Mining Dynamic Load

    Directory of Open Access Journals (Sweden)

    Jiang He

    2015-01-01

    Full Text Available Combination of coal mining dynamic load and high static stress can easily induce such dynamic disasters as rock burst, coal and gas outburst, roof fall, and water inrush. In order to obtain the characteristic parameters of mining dynamic load and dynamic mechanism of coal and rock, the stress wave theory is applied to derive the relation of mining dynamic load strain rate and stress wave parameters. The in situ test was applied to study the stress wave propagation law of coal mine dynamic load by using the SOS microseismic monitoring system. An evaluation method for mining dynamic load strain rate was proposed, and the statistical evaluation was carried out for the range of strain rate. The research results show that the loading strain rate of mining dynamic load is in direct proportion to the seismic frequency of coal-rock mass and particle peak vibration velocity and is in inverse proportion to wave velocity. The high-frequency component damps faster than the low-frequency component in the shockwave propagating process; and the peak particle vibration velocity has a power functional relationship with the transmitting distance. The loading strain rate of mining dynamic load is generally less than class 10−1/s.

  6. Teaching History with Museums: Strategies for K-12 Social Studies

    Science.gov (United States)

    Marcus, Alan; Stoddard, Jeremy; Woodward, Walter W.

    2011-01-01

    "Teaching History with Museums" provides an introduction and overview of the rich pedagogical power of museums. In this comprehensive textbook, the authors show how museums offer a sophisticated understanding of the past and develop habits of mind in ways that are not easily duplicated in the classroom. Using engaging cases to illustrate…

  7. World History. A Program for Senior High School Social Studies.

    Science.gov (United States)

    Waldner, Patrick

    GRADES OR AGES: Senior high school. SUBJECT MATTER: World history. ORGANIZATION AND PHYSICAL APPEARANCE: The guide covers ten units: 1) Perspective--Man in Pre-historic and Ancient Times; 2) Feudalism and the Church in the Middle Ages; 3) Renaissance and Reformation; 4) The Emergence of Nationalism--Its Cause and Effects; 5) Revolutions of Rising…

  8. Relationship between Feline calicivirus Load, Oral Lesions, and Outcome in Feline Chronic Gingivostomatitis (Caudal Stomatitis: Retrospective Study in 104 Cats

    Directory of Open Access Journals (Sweden)

    Isabelle Druet

    2017-12-01

    Full Text Available ObjectiveThis study was performed to assess the relationship between oral Feline calicivirus (FCV load and severity of lesions at the time of presentation of cats suffering from feline chronic gingivostomatitis (FCGS (part 1 and treatment outcome after dental extractions (part 2. We hypothesized that a higher FCV viral load would be positively correlated with the severity of lesions at presentation and negatively correlated with treatment outcome. In addition, the effect of dental extractions on outcome and the influence of preoperative severity of lesions on the outcome were investigated.Materials and methodsCats with FCGS were included in the study if they had been diagnosed with caudal stomatitis, had been tested positive for FCV using a real-time reverse transcriptase-PCR test on oropharyngeal swab, and had dental extractions performed within the authors’ department. General practitioners provided all previous medical treatments. Cats with recheck examinations were included in part 2 of the study. Multivariate statistical analysis was performed to assess the relationship between the different parameters.ResultsOne hundred four cats met the requirements for part 1 and 56 cats for part 2 of the study. Data collected from patients’ record included patient history, viral testing results, extent and severity of oral lesions, extent of teeth extraction. Signalment, history, preoperative treatment, and severity of caudal and alveolar stomatitis score were not associated with FCV load (P > 0.05. Presence of lingual ulcers was significantly correlated with FCV load (P = 0.0325. Clinical cure (32.1% or very significant improvement (19.6% was achieved in 51.8% of cats within 38 days. Concomitantly, 60.7% of the owners considered their cat cured (41.1% or significantly improved (19.6%. Extent of teeth extraction was not found to influence the clinical outcome (P > 0.05.ConclusionThe results of this study did not support the hypothesis

  9. The role of the demand-duration curve in the evaluation of power station installation policies. Remarks on its effects on stations' utilization, generating capacity, load factor history and consumptions

    International Nuclear Information System (INIS)

    Graziani, G.; Maineri, M.; Zanantoni, C.

    1976-12-01

    The role of the load-duration curve in determining the installation policy for an electric power system, is examined. The effect of the priority order for the allocation of the power stations in the load-diagram is also discussed: in the model used here (program TOTEM) this priority is given as a function of type and age of the station. The significance of the load factor history for a power station as a function of its age is also discussed. It is suggested that such a curve be deduced as a result of strategy calculations made with TOTEM rather than assumping it as input data

  10. Studies on load metric and communication for a load balancing algorithm in a distributed data acquisition system

    International Nuclear Information System (INIS)

    Simon, M; Kozielski, S; Sakulin, H

    2011-01-01

    The proposed method is designed for a data acquisition system acquiring data from n independent sources. The data sources are supposed to produce fragments that together constitute some logical wholeness. These fragments are produced with the same frequency and in the same sequence. The discussed algorithm aims to balance the data dynamically between m logically autonomous processing units (consisting of computing nodes) in case of variation in their processing power which could be caused by some faults like failing computing nodes, or broken network connections. As a case study we consider the Data Acquisition System of the Compact Muon Solenoid Experiment at CERN's new Large Hadron Collider. The system acquires data from about 500 sources and combines them into full events. Each data source is expected to deliver event fragments of an average size of 2 kB with 100 kHz frequency. In this paper we present the results of applying proposed load metric and load communication pattern. Moreover, we discuss their impact on the algorithm's overall efficiency and scalability, as well as on fault tolerance of the whole system. We also propose a general concept of an algorithm that allows for choosing the destination processing unit in all source nodes asynchronously and asserts that all fragments of same logical data always go to same unit.

  11. Seasonal player wellness and its longitudinal association with internal training load: study in elite volleyball.

    Science.gov (United States)

    Clemente, Filipe M; Mendes, Bruno; Palao, José M; Silvério, André; Carriço, Sandro; Calvete, Francisco; Nakamura, Fábio Y

    2018-04-04

    Monitoring training load is critical to minimize the risk of overreaching, injury or illness. The purpose of this study was to assess the relationships and variance between perceived internal load and wellness status of elite male volleyball. Thirteen elite volleyball players were studied during a full competitive season (nine months, 237 training sessions and 37 official matches). Perceived exertion, muscle soreness, stress, fatigue and sleep quality levels were daily measured using session RPE and the Hopper Questionnaire. Moderate-to-large correlations were found between weekly training load and perceived status of muscle soreness, fatigue and stress. Stronger correlations were found between weekly training loads than daily training load. Significant greater stress levels in match days than in training were found. No correlations between load and wellness were not found in the last month when players perceived higher levels of stress due to the competition. The analysis of the weekly training load had a higher relationship with players' wellness status in pre-season and middle of the season. In the last part of the season (final matches for the title), despite of a decrease in perceived load of last month of the season, there was an increase stress and fatigue levels. These results suggest the importance of including the impact on the competition when elite athletes are monitored. The results show the monitoring tools used may help in to characterize the training process of teams and the player's acute and chronic responses.

  12. Depositional history and fault-related studies, Bolinas Lagoon, California

    Science.gov (United States)

    Berquist, Joel R.

    1978-01-01

    Studies of core sediments and seismic reflection profiles elucidate the structure and depositional history of Bolinas Lagoon, Calif., which covers 4.4 km 2 and lies in the San Andreas fault zone at the southeast corner of the Point Reyes Peninsula 20 km northwest of San Francisco. The 1906 trace of the San Andreas fault crosses the west side of the lagoon and was determined from (1) tectonically caused salt-marsh destruction indicated by comparison of 1854 and 1929 U.S. Coast and Geodetic Survey (U.S.C. & G.S.) topographic surveys, (2) formation of a tidal channel along the border of destroyed salt marshes, and (3) azimuths of the trend of the fault measured in 1907. Subsidence in the lagoon of 30 cm occurred east of the San Andreas fault in 1906. Near the east shore, seismic-reflection profiling indicates the existence of a graben fault that may connect to a graben fault on the Golden Gate Platform. Comparison of radiocarbon dates on shells and plant debris from boreholes drilled on Stinson Beach spit with a relative sea-level curve constructed for southern San Francisco Bay indicates 5.8 to more than 17.9 m of tectonic subsidence of sediments now located 33 m below mean sea level. Cored sediments indicate a marine transgression dated at 7770?65 yrs B.P. overlying freshwater organic-rich lake deposits. Fossil pollen including 2 to 8 percent Picea (spruce) indicate a late Pleistocene (?)-Early Holocene climate, cooler, wetter, and foggier than at present. Above the transgression are discontinuous and interfingering sequences of transgressive-regressive marine, estuarine, and barrier sediments that reflect rapid lateral and vertical shifts of successive depositional environments. Fossil megafauna indicate (1) accumulation in a protected, shallow-water estuary or bay, and (2) that the lagoon was probably continuously shallow and never a deep-water embayment. Analysis of grain-size parameters, pollen frequencies, and organic remains from a core near the north end of

  13. A Guide to the Study and Use of Military History

    Science.gov (United States)

    1988-01-01

    psychological, and quantitative techniques to older as well as newer forms of history. The legacy of ferment left from older debates in historical...Western expansion into Africa, Asia, and South America introduced ferment and instability into what had been areas of high social, economic, and political...the leading American figure there, Joseph W. (" Vinegar Joe") Stilwell, and because of the enigma of American relations with China and its generalissimo

  14. FY 93 thermal loading systems study final report: Volume 1. Revision 1

    International Nuclear Information System (INIS)

    Saterlie, S.F.; Thomson, B.H.

    1994-01-01

    The ability to meet the overall performance requirements for the proposed Mined Geology Disposal System at Yucca Mountain, Nevada requires the two major subsystem (natural barriers and engineered barriers) to positively contribute to containment and radionuclide isolation. In addition to the postclosure performance the proposed repository must meet preclosure requirements of safety, retrievability, and operability. Cost and schedule were also considered. The thermal loading strategy chosen may significantly affect both the postclosure and preclosure performance of the proposed repository. Although the current Site Characterization Plan reference case is 57 kilowatts (kW)/acre, other thermal loading strategies (different areal mass loadings) have been proposed which possess both advantages and disadvantages. The objectives of the FY 1993 Thermal Loading Study were to (1) place bounds on the thermal loading which would establish the loading regime that is ''too hot'' and the loading regime that is ''too cold'', to (2) ''grade'' or evaluate the performance, as a function of thermal loading, of the repository to contain high level wastes against performance criteria and to (3) evaluate the performance of the various options with respect to cost, safety, and operability. Additionally, the effort was to (4) identify important uncertainties that need to be resolved by tests and/or analyses in order to complete a performance assessment on the effects of thermal loading. The FY 1993 Thermal Loading Study was conducted from December 1, 1992 to December 30, 1993 and this final report provides the findings of the study. Volume 1 contains the Introduction; Performance requirements; Input and assumptions; Near-field thermal analysis; Far-field thermal analysis; Cost analysis; Other considerations; System analysis; Additional thermal analysis; and Conclusions and recommendations. 71 refs., 54 figs

  15. Experimental study of a macrocrack propagation in a concrete specimen subjected to creep loading

    Science.gov (United States)

    Rossi, P.; Boulay, C.; Tailhan, J.-L.; Martin, E.

    2013-07-01

    Structures managers need a better prediction of the delayed failure of concrete structures, especially for very important structures like nuclear power plant encasement. Sustained loadings at high level (above 75% of loading capacity of the structure), can lead to structure failure after some time. In this study, a series of 4-point bending tests were performed in order to characterize the creep behaviour of pre-cracked beams under high load level. The specimens were made of normal strength concrete. A power law relationship is observed between the secondary deflection creep rate and the failure time. It is also shown that when crack propagation occurs during the creep loading, the creep deflection rate increases with the creep loading level and with the crack propagation rate.

  16. Characteristic study of high-Tc superconducting maglev under side-loading

    International Nuclear Information System (INIS)

    Wang Wei; Wang Jiasu; Liu Wei; Zheng Jun; Lin Qunxu; Pan Siting; Deng Zigang; Ma Guangtong; Wang Suyu

    2009-01-01

    In practical application of High-T c Superconducting (HTS) maglev, slant is an observable defect. It was caused by constantly one side on and off the vehicle by passengers. So far, this phenomenon has not been reported yet. In order to understand its influence on the stability of the HTS maglev, we experimentally studied the dynamic characteristic and slant effect of HTS maglev under center-load and side-load. It was found that load destabilizes the vehicle, and the side-load can obviously slant the vehicle body. In the end, the pre-load method was proposed to enhance the dynamic stability and suppress the slant, which proved to be considerably effective. These results are critical in practical running of HTS maglev

  17. Characteristic study of high-T{sub c} superconducting maglev under side-loading

    Energy Technology Data Exchange (ETDEWEB)

    Wang Wei [Applied Superconductivity Laboratory, M/S 152, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China)], E-mail: frank.weiwang@gmail.com; Wang Jiasu [Applied Superconductivity Laboratory, M/S 152, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China)], E-mail: asclab@asclab.cn; Liu Wei; Zheng Jun; Lin Qunxu; Pan Siting; Deng Zigang; Ma Guangtong; Wang Suyu [Applied Superconductivity Laboratory, M/S 152, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China)

    2009-02-15

    In practical application of High-T{sub c} Superconducting (HTS) maglev, slant is an observable defect. It was caused by constantly one side on and off the vehicle by passengers. So far, this phenomenon has not been reported yet. In order to understand its influence on the stability of the HTS maglev, we experimentally studied the dynamic characteristic and slant effect of HTS maglev under center-load and side-load. It was found that load destabilizes the vehicle, and the side-load can obviously slant the vehicle body. In the end, the pre-load method was proposed to enhance the dynamic stability and suppress the slant, which proved to be considerably effective. These results are critical in practical running of HTS maglev.

  18. Analysis and Synthesis of Load Forecasting Data for Renewable Integration Studies: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Steckler, N.; Florita, A.; Zhang, J.; Hodge, B. M.

    2013-11-01

    As renewable energy constitutes greater portions of the generation fleet, the importance of modeling uncertainty as part of integration studies also increases. In pursuit of optimal system operations, it is important to capture not only the definitive behavior of power plants, but also the risks associated with systemwide interactions. This research examines the dependence of load forecast errors on external predictor variables such as temperature, day type, and time of day. The analysis was utilized to create statistically relevant instances of sequential load forecasts with only a time series of historic, measured load available. The creation of such load forecasts relies on Bayesian techniques for informing and updating the model, thus providing a basis for networked and adaptive load forecast models in future operational applications.

  19. Expert System Models for Forecasting Forklifts Engagement in a Warehouse Loading Operation: A Case Study

    Directory of Open Access Journals (Sweden)

    Dejan Mirčetić

    2016-08-01

    Full Text Available The paper focuses on the problem of forklifts engagement in warehouse loading operations. Two expert system (ES models are created using several machine learning (ML models. Models try to mimic expert decisions while determining the forklifts engagement in the loading operation. Different ML models are evaluated and adaptive neuro fuzzy inference system (ANFIS and classification and regression trees (CART are chosen as the ones which have shown best results for the research purpose. As a case study, a central warehouse of a beverage company was used. In a beverage distribution chain, the proper engagement of forklifts in a loading operation is crucial for maintaining the defined customer service level. The created ES models represent a new approach for the rationalization of the forklifts usage, particularly for solving the problem of the forklifts engagement incargo loading. They are simple, easy to understand, reliable, and practically applicable tool for deciding on the engagement of the forklifts in a loading operation.

  20. Prevalence of Trichomonas vaginalis infection and protozoan load in South African women: a cross-sectional study

    Science.gov (United States)

    de Waaij, Dewi J

    2017-01-01

    Objectives Trichomonas vaginalis is thought to be the most common non-viral sexually transmitted infection worldwide. We investigated the prevalence, risk factors and protozoan load of T. vaginalis infection in South African women. Methods A cross-sectional study of 604 women was conducted at 25 primary healthcare facilities in rural South Africa (Mopani district). T. vaginalis DNA was detected in vaginal and rectal swabs. In univariate and multivariate analyses, the T. vaginalis infection was investigated in relation to demographic characteristics, medical history and behavioural factors. The T. vaginalis load was determined as the logarithm of DNA copies per microlitre sample solution. Results Collected vaginal and rectal swabs were tested for T. vaginalis DNA. Prevalence of vaginal T. vaginalis was 20% (95% CI 17.0% to 23.4%) and rectal 1.2% (95% CI 0.6% to 2.4%). Most women (66%) with a vaginal infection were asymptomatic. Factors associated with T. vaginalis infection were a relationship status of single (OR 2.4; 95% CI 1.5 to 4.0; pvaginalis infection were more likely to have concurrent Chlamydia trachomatis rectal infection than those without vaginal infection (12%vs3%; pvaginalis load was observed among women with observed vaginal discharge compared with those without vaginal discharge (p=0.025). Conclusions Vaginal trichomoniasis is highly prevalent in rural South Africa, especially among single women and those with HIV infection, and often presents without symptoms. PMID:28993385

  1. Soil mechanical stresses in high wheel load agricultural field traffic: a case study

    DEFF Research Database (Denmark)

    Lamandé, Mathieu; Schjønning, Per

    2017-01-01

    highly skewed. Across tyres, the maximum stress in the contact area correlated linearly with, but was much higher than, the mean ground pressure. For each of the three soil depths, the maximum stresses under the tyres were significantly correlated with the wheel load, but not with other loading......Subsoil compaction is a serious long-term threat to soil functions. Only a few studies have quantified the mechanical stresses reaching deep subsoil layers for modern high wheel load machinery. In the present study we measured the vertical stresses in the tyre–soil contact area and at 0.3, 0...

  2. Canadian House Dust Study: Population-based concentrations, loads and loading rates of arsenic, cadmium, chromium, copper, nickel, lead, and zinc inside urban homes

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, Pat E. [Exposure and Biomonitoring Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, ON, Canada K1A 0K9 (Canada); Department of Earth Sciences, University of Ottawa, 140 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); Levesque, Christine [Exposure and Biomonitoring Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, ON, Canada K1A 0K9 (Canada); Chénier, Marc; Gardner, H. David [Exposure and Biomonitoring Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, ON, Canada K1A 0K9 (Canada); Department of Earth Sciences, University of Ottawa, 140 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); Jones-Otazo, Heather [Regions and Programs Branch, Health Canada, 180 Queen Street West, Toronto, ON, Canada M5V 3L7 (Canada); Petrovic, Sanya [Contaminated Sites Division, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave West, Ottawa, ON, Canada K1A 0K9 (Canada)

    2013-01-15

    The Canadian House Dust Study was designed to obtain nationally representative urban house dust metal concentrations (μg g{sup −1}) and metal loadings (μg m{sup −2}) for arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn). Consistent sampling of active dust of known age and provenance (area sampled) also permitted the calculation of indoor loading rates (mg m{sup −2} day{sup −1} for dust and μg m{sup −2} day{sup −1} for metals) for the winter season (from 2007 to 2010) when houses are most tightly sealed. Geomean/median indoor dust loading rates in homes located more than 2 km away from industry of any kind (9.6/9.1 mg m{sup −2} day{sup −1}; n = 580) were significantly lower (p < .001) than geomean (median) dust loading rates in homes located within 2 km of industry (13.5/13.4 mg m{sup −2} day{sup −1}; n = 421). Proximity to industry was characterized by higher indoor metal loading rates (p < .003), but no difference in dust metal concentrations (.29 ≥ p ≤ .97). Comparisons of non-smokers' and smokers' homes in non-industrial zones showed higher metal loading rates (.005 ≥ p ≤ .038) in smokers' homes, but no difference in dust metal concentrations (.15 ≥ p ≤ .97). Relationships between house age and dust metal concentrations were significant for Pb, Cd and Zn (p < .001) but not for the other four metals (.14 ≥ p ≤ .87). All seven metals, however, displayed a significant increase in metal loading rates with house age (p < .001) due to the influence of higher dust loading rates in older homes (p < .001). Relationships between three measures of metals in house dust – concentration, load, and loading rate – in the context of house age, smoking behavior and urban setting consistently show that concentration data is a useful indicator of the presence of metal sources in the home, whereas dust mass is the overriding influence on metal loadings and loading rates

  3. Study of damage of graphite/epoxy composites submitted to repeated quasi-static shear loadings

    International Nuclear Information System (INIS)

    Khadhraoui-Lattreche, Malika

    1984-01-01

    Quasi static loading tests on composite materials with organic matrix allow the behaviour of the materials under repeated loadings to be studied while avoiding viscoelastic effects. In this research thesis, the author reports the study of one-directional composite samples submitted to static pure shear loadings which represent the most severe stress state for this type of material. The material behaviour has been determined by application of loads greater than the yield strength, and of zero torque unloads. This allowed cumulative residual deformations to be monitored, and the increasing evolution of this parameter to be studied with respect to the number of applied cycles. The author deduces from these results a characteristic law for the material which introduces a decoupling between the stress and the cumulative residual deformation. Thus, a method of prediction of cumulative residual deformations is developed. Besides, a brief application to another material seems to confirm this type of law, and suggests that its generalisation should be studied [fr

  4. Training Load and Fatigue Marker Associations with Injury and Illness: A Systematic Review of Longitudinal Studies.

    Science.gov (United States)

    Jones, Christopher M; Griffiths, Peter C; Mellalieu, Stephen D

    2017-05-01

    Coaches, sport scientists, clinicians and medical personnel face a constant challenge to prescribe sufficient training load to produce training adaption while minimising fatigue, performance inhibition and risk of injury/illness. The aim of this review was to investigate the relationship between injury and illness and longitudinal training load and fatigue markers in sporting populations. Systematic searches of the Web of Science and PubMed online databases to August 2015 were conducted for articles reporting relationships between training load/fatigue measures and injury/illness in athlete populations. From the initial 5943 articles identified, 2863 duplicates were removed, followed by a further 2833 articles from title and abstract selection. Manual searching of the reference lists of the remaining 247 articles, together with use of the Google Scholar 'cited by' tool, yielded 205 extra articles deemed worthy of assessment. Sixty-eight studies were subsequently selected for inclusion in this study, of which 45 investigated injury only, 17 investigated illness only, and 6 investigated both injury and illness. This systematic review highlighted a number of key findings, including disparity within the literature regarding the use of various terminologies such as training load, fatigue, injury and illness. Athletes are at an increased risk of injury/illness at key stages in their training and competition, including periods of training load intensification and periods of accumulated training loads. Further investigation of individual athlete characteristics is required due to their impact on internal training load and, therefore, susceptibility to injury/illness.

  5. Mechanical properties of stanene under uniaxial and biaxial loading: A molecular dynamics study

    Energy Technology Data Exchange (ETDEWEB)

    Mojumder, Satyajit [Department of Mechanical Engineering, Bangladesh University of Engineering and Technology, Dhaka 1000 (Bangladesh); Amin, Abdullah Al [Department of Mechanical and Aerospace Engineering, Case western Reverse University, Cleveland, Ohio 44106 (United States); Islam, Md Mahbubul, E-mail: mmi122@psu.edu [Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802 (United States)

    2015-09-28

    Stanene, a graphene like two dimensional honeycomb structure of tin has attractive features in electronics application. In this study, we performed molecular dynamics simulations using modified embedded atom method potential to investigate mechanical properties of stanene. We studied the effect of temperature and strain rate on mechanical properties of α-stanene for both uniaxial and biaxial loading conditions. Our study suggests that with the increasing temperature, both the fracture strength and strain of the stanene decrease. Uniaxial loading in zigzag direction shows higher fracture strength and strain compared to the armchair direction, while no noticeable variation in the mechanical properties is observed for biaxial loading. We also found at a higher loading rate, material exhibits higher fracture strength and strain. These results will aid further investigation of stanene as a potential nano-electronics substitute.

  6. 3D Modeling and Printing in History/Social Studies Classrooms: Initial Lessons and Insights

    Science.gov (United States)

    Maloy, Robert; Trust, Torrey; Kommers, Suzan; Malinowski, Allison; LaRoche, Irene

    2017-01-01

    This exploratory study examines the use of 3D technology by teachers and students in four middle school history/social studies classrooms. As part of a university-developed 3D Printing 4 Teaching & Learning project, teachers integrated 3D modeling and printing into curriculum topics in world geography, U.S. history, and government/civics.…

  7. User Experience Design of History Game: An Analysis Review and Evaluation Study for Malaysia Context

    Science.gov (United States)

    Wong, Seng Yue; Ghavifekr, Simin

    2018-01-01

    User experience (UX) and user interface design of an educational game are important in enhancing and sustaining the utilisation of Game Based Learning (GBL) in learning history. Thus, this article provides a detailed literature review on history learning problems, as well as previous studies on user experience in game design. Future studies on…

  8. A Content Analysis Study about the Usage of History of Mathematics in Textbooks in Turkey

    Science.gov (United States)

    Eren, Mehmet; Bulut, Mehmet; Bulut, Neslihan

    2015-01-01

    The present study aimed to investigate how history of mathematics was integrated to some mathematics textbooks in Turkey. On this account, four different textbooks with different grade levels were chosen. In total, 42 cases were detected and studied by three researchers. Results indicated that the usage of history of mathematics was materialized…

  9. Impact of working memory load on cognitive control in trait anxiety: an ERP study.

    Science.gov (United States)

    Qi, Senqing; Zeng, Qinghong; Luo, Yangmei; Duan, Haijun; Ding, Cody; Hu, Weiping; Li, Hong

    2014-01-01

    Whether trait anxiety is associated with a general impairment of cognitive control is a matter of debate. This study investigated whether and how experimentally manipulated working memory (WM) load modulates the relation between trait anxiety and cognitive control. This question was investigated using a dual-task design in combination with event-related potentials. Participants were required to remember either one (low WM load) or six letters (high WM load) while performing a flanker task. Our results showed that a high WM load disrupted participants' ability to overcome distractor interference and this effect was exacerbated for the high trait-anxious (HTA) group. This exacerbation was reflected by larger interference effects (i.e., incongruent minus congruent) on reaction times (RTs) and N2 amplitudes for the HTA group than for the low trait-anxious group under high WM load. The two groups, however, did not differ in their ability to inhibit task-irrelevant distractors under low WM load, as indicated by both RTs and N2 amplitudes. These findings underscore the significance of WM-related cognitive demand in contributing to the presence (or absence) of a general cognitive control deficit in trait anxiety. Furthermore, our findings show that when limited WM resources are depleted by high WM load, HTA individuals exhibit less efficient recruitments of cognitive control required for the inhibition of distractors, therefore resulting in a greater degree of response conflict.

  10. Impact of working memory load on cognitive control in trait anxiety: an ERP study.

    Directory of Open Access Journals (Sweden)

    Senqing Qi

    Full Text Available Whether trait anxiety is associated with a general impairment of cognitive control is a matter of debate. This study investigated whether and how experimentally manipulated working memory (WM load modulates the relation between trait anxiety and cognitive control. This question was investigated using a dual-task design in combination with event-related potentials. Participants were required to remember either one (low WM load or six letters (high WM load while performing a flanker task. Our results showed that a high WM load disrupted participants' ability to overcome distractor interference and this effect was exacerbated for the high trait-anxious (HTA group. This exacerbation was reflected by larger interference effects (i.e., incongruent minus congruent on reaction times (RTs and N2 amplitudes for the HTA group than for the low trait-anxious group under high WM load. The two groups, however, did not differ in their ability to inhibit task-irrelevant distractors under low WM load, as indicated by both RTs and N2 amplitudes. These findings underscore the significance of WM-related cognitive demand in contributing to the presence (or absence of a general cognitive control deficit in trait anxiety. Furthermore, our findings show that when limited WM resources are depleted by high WM load, HTA individuals exhibit less efficient recruitments of cognitive control required for the inhibition of distractors, therefore resulting in a greater degree of response conflict.

  11. Study of Flexible Load Dispatch to Improve the Capacity of Wind Power Absorption

    Science.gov (United States)

    Yunlei, Yang; Shifeng, Zhang; Xiao, Chang; Da, Lei; Min, Zhang; Jinhao, Wang; Shengwen, Li; Huipeng, Li

    2017-05-01

    The dispatch method which track the trend of load demand by arranging the generation scheme of controllable hydro or thermal units faces great difficulties and challenges. With the increase of renewable energy sources such as wind power and photovoltaic power introduced to grid, system has to arrange much more spinning reserve units to compensate the unbalanced power. How to exploit the peak-shaving potential of flexible load which can be shifted with time or storage energy has become many scholars’ research direction. However, the modelling of different kinds of load and control strategy is considerably difficult, this paper choose the Air Conditioner with compressor which can storage energy in fact to study. The equivalent thermal parameters of Air Conditioner has been established. And with the use of “loop control” strategies, we can predict the regulated power of Air Conditioner. Then we established the Gen-Load optimal scheduling model including flexible load based on traditional optimal scheduling model. At last, an improved IEEE-30 case is used to verify. The result of simulation shows that flexible load can fast-track renewable power changes. More than that, with flexible load and reasonable incentive method to consumers, the operating cost of the system can be greatly cut down.

  12. Analysis of postural load during tasks related to milking cows-a case study.

    Science.gov (United States)

    Groborz, Anna; Tokarski, Tomasz; Roman-Liu, Danuta

    2011-01-01

    The aim of this study was to analyse postural load during tasks related to milking cows of 2 farmers on 2 different farms (one with a manual milk transport system, the other with a fully automated milk transport system) as a case study. The participants were full-time farmers, they were both healthy and experienced in their job. The Ovako Working Posture Analyzing System (OWAS) was used to evaluate postural load and postural risk. Postural load was medium for the farmer on the farm with a manual milk transport system and high for the farmer working on the farm with a fully automated milk transport system. Thus, it can be concluded that a higher level of farm mechanization not always mean that the farmer's postural load is lower, but limitation of OWAS should be considered.

  13. Young children's family history of stuttering and their articulation, language and attentional abilities: An exploratory study.

    Science.gov (United States)

    Choi, Dahye; Conture, Edward G; Tumanova, Victoria; Clark, Chagit E; Walden, Tedra A; Jones, Robin M

    The purpose of this study was to determine whether young children who do (CWS) and do not stutter (CWNS) with a positive versus negative family history of stuttering differ in articulation, language and attentional abilities and family histories of articulation, language and attention related disorders. Participants were 25 young CWS and 50 young CWNS. All 75 participants' caregivers consistently reported a positive or negative family history of stuttering across three consecutive time points that were about 8 months apart for a total of approximately 16 months. Each participant's family history focused on the same, relatively limited number of generations (i.e., participants' parents & siblings). Children's family history of stuttering as well as articulation, language, and attention related disorders was obtained from one or two caregivers during an extensive interview. Children's speech and language abilities were measured using four standardized articulation and language tests and their attentional abilities were measured using caregiver reports of temperament. Findings indicated that (1) most caregivers (81.5% or 75 out 92) were consistent in their reporting of positive or negative history of stuttering; (2) CWNS with a positive family history of stuttering, compared to those with a negative family history of stuttering, were more likely to have reported a positive family history of attention deficit/hyperactivity disorder (ADHD), and (3) CWNS with a positive family history of stuttering had lower language scores than those with a negative family history of stuttering. However, there were no such significant differences in family histories of ADHD and language scores for CWS with a positive versus negative family history of stuttering. In addition, although 24% of CWS versus 12% of CWNS's caregivers reported a positive family history of stuttering, inferential analyses indicated no significant differences between CWS and CWNS in relative proportions of family

  14. A study of the importance of occupancy to building cooling load in prediction by intelligent approach

    International Nuclear Information System (INIS)

    Kwok, Simon S.K.; Lee, Eric W.M.

    2011-01-01

    Research highlights: → The building occupancy affecting the cooling load prediction is studied. → PENN model is adopted in this study for predicting the building cooling load. → Statistical approach is adopted to result a less prejudice prediction performance. → Results show that occupancy data can significantly improve the prediction. -- Abstract: Building cooling load prediction is one of the key factors in the success of energy-saving measures. Many computational models available in the industry today have been developed from either forward or inverse modeling approaches. However, most of these models require extensive computer resources and involve lengthy computation. This paper discusses the use of data-driven intelligent approaches, a probabilistic entropy-based neural (PENN) model to predict the cooling load of a building. Although it is common knowledge that the presence and activity of building occupants have a significant impact on the required cooling load of buildings, practices currently adopted in modeling the presence and activity of people in buildings do not reflect the complexity of the impact occupants have on building cooling load. In contrast to previous artificial neural network (ANN) models, most of which employ a fixed schedule or historic load data to represent building occupancy in simulating building cooling load, this paper introduces two input parameters, dynamic occupancy area and rate and uses it to mimic building cooling load. The training samples used include weather data obtained from the Hong Kong Observatory and building-related data acquired from an existing grade A mega office buildings in Hong Kong with tenants including many multi-national financial companies that require 24-h air conditioning seven days a week. The dynamic changes that occur in the occupancy of these buildings therefore make it very difficult to forecast building cooling load by means of a fixed time schedule. The performance of simulation results

  15. A study of the importance of occupancy to building cooling load in prediction by intelligent approach

    Energy Technology Data Exchange (ETDEWEB)

    Kwok, Simon S.K. [Department of Building and Construction, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong (Hong Kong); Lee, Eric W.M., E-mail: ericlee@cityu.edu.h [Department of Building and Construction, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong (Hong Kong)

    2011-07-15

    Research highlights: {yields} The building occupancy affecting the cooling load prediction is studied. {yields} PENN model is adopted in this study for predicting the building cooling load. {yields} Statistical approach is adopted to result a less prejudice prediction performance. {yields} Results show that occupancy data can significantly improve the prediction. -- Abstract: Building cooling load prediction is one of the key factors in the success of energy-saving measures. Many computational models available in the industry today have been developed from either forward or inverse modeling approaches. However, most of these models require extensive computer resources and involve lengthy computation. This paper discusses the use of data-driven intelligent approaches, a probabilistic entropy-based neural (PENN) model to predict the cooling load of a building. Although it is common knowledge that the presence and activity of building occupants have a significant impact on the required cooling load of buildings, practices currently adopted in modeling the presence and activity of people in buildings do not reflect the complexity of the impact occupants have on building cooling load. In contrast to previous artificial neural network (ANN) models, most of which employ a fixed schedule or historic load data to represent building occupancy in simulating building cooling load, this paper introduces two input parameters, dynamic occupancy area and rate and uses it to mimic building cooling load. The training samples used include weather data obtained from the Hong Kong Observatory and building-related data acquired from an existing grade A mega office buildings in Hong Kong with tenants including many multi-national financial companies that require 24-h air conditioning seven days a week. The dynamic changes that occur in the occupancy of these buildings therefore make it very difficult to forecast building cooling load by means of a fixed time schedule. The performance of

  16. Comparison of three methods of calculating strain in the mouse ulna in exogenous loading studies.

    Science.gov (United States)

    Norman, Stephanie C; Wagner, David W; Beaupre, Gary S; Castillo, Alesha B

    2015-01-02

    Axial compression of mouse limbs is commonly used to induce bone formation in a controlled, non-invasive manner. Determination of peak strains caused by loading is central to interpreting results. Load-strain calibration is typically performed using uniaxial strain gauges attached to the diaphyseal, periosteal surface of a small number of sacrificed animals. Strain is measured as the limb is loaded to a range of physiological loads known to be anabolic to bone. The load-strain relationship determined by this subgroup is then extrapolated to a larger group of experimental mice. This method of strain calculation requires the challenging process of strain gauging very small bones which is subject to variability in placement of the strain gauge. We previously developed a method to estimate animal-specific periosteal strain during axial ulnar loading using an image-based computational approach that does not require strain gauges. The purpose of this study was to compare the relationship between load-induced bone formation rates and periosteal strain at ulnar midshaft using three different methods to estimate strain: (A) Nominal strain values based solely on load-strain calibration; (B) Strains calculated from load-strain calibration, but scaled for differences in mid-shaft cross-sectional geometry among animals; and (C) An alternative image-based computational method for calculating strains based on beam theory and animal-specific bone geometry. Our results show that the alternative method (C) provides comparable correlation between strain and bone formation rates in the mouse ulna relative to the strain gauge-dependent methods (A and B), while avoiding the need to use strain gauges. Published by Elsevier Ltd.

  17. The Application of Load-cell Technique in the Study of Armour Unit Responses to Impact Loads

    OpenAIRE

    Burcharth, H. F.; Liu, Zhou

    1994-01-01

    The slender, complex types of armour units, such as Tetrapods and Dolosse arewidely used for rubble mound breakwaters. Many of the recent failures of such structures were caused by unforeseen early breakage of the units, thus revealing an inbalance between the strength (structural integrity) of the units and the hydraulic stability (resistance to displacements) of the armour layers. Breakage is caused by stresses from static, pulsating and impact loads. Impact load generated stresses are diff...

  18. The Application of Load-cell Technique in the Study of Armour Unit Responses to Impact Loads Tests

    OpenAIRE

    Burcharth, H. F.; Liu, Z.

    1995-01-01

    The slender, complex types of armour units, such as Tetrapods and Dolosse arewidely used for rubble mound breakwaters. Many of the recent failures of suchstructures were caused by unforeseen early breakage of the units, thus revealingan in balance between the strength (structural integrity) of the units and thehydraulic stability (resistance to displacements) of the armour layers. Breakageis caused by stresses from static, pulsating and impact loads. Impact load generated stresses are difficu...

  19. World History and Global Consciousness: A Case Study in the Scholarship of Teaching and Learning

    Science.gov (United States)

    Quirin, James A.

    2009-01-01

    World history has become part of the "revolution in historical studies" since the 1960s, and a fast-growing area of college teaching in recent years. This article reports the author's research on his own world history-based course at Fisk University under the rubric of the Scholarship of Teaching and Learning (SoTL). This SoTL research suggests…

  20. Embodied Experiences of Place: A Study of History Learning with Mobile Technologies

    Science.gov (United States)

    Price, S.; Jewitt, C.; Sakr, M.

    2016-01-01

    This paper reports an empirical study that takes a multimodal analytical approach to examine how mobile technologies shape students' exploration and experience of place during a history learning activity in situ. In history education, mobile technologies provide opportunities for authentic experiential learning activities that have the potential…

  1. A Categorization Model for Educational Values of the History of Mathematics: An Empirical Study

    Science.gov (United States)

    Wang, Xiao-qin; Qi, Chun-yan; Wang, Ke

    2017-01-01

    There is not a clear consensus on the categorization framework of the educational values of the history of mathematics. By analyzing 20 Chinese teaching cases on integrating the history of mathematics into mathematics teaching based on the relevant literature, this study examined a new categorization framework of the educational values of the…

  2. Extra-Curricular Social Studies in an Open Air History Museum

    Science.gov (United States)

    Morris, Ronald Vaughan

    2008-01-01

    This article discusses extra-curricular social studies in an Open Air History Museum. Open Air History Museum, Conner Prairie Interpretive Park in Fishers, Indiana, is a cultural institution that encourages and supports talented students as they participate in an extra-curricular program. Ten-to sixteen-year-old youths "apply for jobs"…

  3. Ethiopian society and history : a bibliography of Ethiopian studies 1957-1990

    NARCIS (Netherlands)

    Abbink, G.J.

    1990-01-01

    Comprehensive overview of publications on Ethiopia published between c. 1957 up to 1990. The 5433 entries are arranged according to the following broad subject areas: Bibliographies - History of Ethiopianist studies - Studies on manuscripts, documents, archives and library resources - Travellers and

  4. Natural history of polyomaviruses in men: the HPV infection in men (HIM) study.

    Science.gov (United States)

    Hampras, Shalaka S; Giuliano, Anna R; Lin, Hui-Yi; Fisher, Kate J; Abrahamsen, Martha E; McKay-Chopin, Sandrine; Gheit, Tarik; Tommasino, Massimo; Rollison, Dana E

    2015-05-01

    Several new polyomaviruses have been discovered in the last decade, including Merkel cell polyomavirus (MCPyV). Little is known about the natural history of the more recently discovered polyomaviruses. We estimated the incidence, prevalence, and persistence of 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPyV6], HPyV7, HPyV9, and Trichodysplasia spinulosa-associated polyomavirus) and examined factors associated with MCPyV infection in a prospective cohort of 209 men initially enrolled in the HPV Infection in Men (HIM) study. Participants enrolled at the US site of the HIM study were recruited into a substudy of cutaneous viral infections and followed for a median of 12.6 months. Eyebrow hair and normal skin swab specimens were obtained at each study visit, and the viral DNA load was measured using multiplex polymerase chain reaction. MCPyV infection showed the highest prevalence (65.1% of normal skin swab specimens and 30.6% of eyebrow hair specimens), incidence (81.7 cases per 1000 person-months among normal skin swab specimens, and 24.1 cases per 1000 person-months among eyebrow hair specimens), and persistence (85.8% of normal skin swab specimens and 58.9% of eyebrow hair specimens) among all polyomaviruses examined. Age of >44 years (odds ratio [OR], 2.11; 95% confidence interval [CI], 1.03-4.33) and Hispanic race (OR, 2.64; 95% CI, 1.01-6.88) were associated with an increased prevalence of MCPyV infection in eyebrow hair and normal skin swab specimens, respectively. MCPyV infection is highly prevalent in adults, with age and race being predisposing factors. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. [The trend and prospect of studies on the history of Western medicine in Korea.].

    Science.gov (United States)

    Kim, Ock Joo

    2010-06-30

    Studies on the history of Western medicine in Korea began to be actively conducted and published since the restart of the Korean Society for the History of Medicine in 1991, which had been originally inaugurated in 1947, and the publication of its official journal, the Korean Journal of Medical History in 1992. In 1970s and 1980s, even before the start of the Journal, articles on a history of Western medicine were published mainly written by physicians in medical journals. This paper aims to provide an overview of the publications on the history of Western medicine in Korea, comparing papers published in the Journal with those published in other journals. Authors of the papers in the Journal are those who majored in history of medicine or history science whose initial educational backgrounds were medicine or science, whereas authors of the papers in other journals majored in Western history, economic history, social history, religious history, or women's history. While a large portion of papers in the Journal deal with medicine in ancient Greek or in modern America with no paper on medieval medicine, the papers in other journals deal with more various periods including ancient, medieval and modern periods and with diverse areas including France, Britain, Germany, Europe etc. Recent trends in 2000s show an increase in the number of researchers who published the history of Western medicine in other journals, total number of their publications, and the topics that they dealt with in their papers. In contrast, however, the number of researchers published in the Journal, the number of the papers and its topics - all decreased in recent years. Only three papers on the history of diseases have been published in the Journal, while eleven published in other journals. In order to stimulate research on the history of Western medicine in Korea, concerted efforts are necessary including academic communication among various disciplines, formulation of a long term plan to enlarge

  6. Drug-polymer interaction studies of cytarabine loaded chitosan nanoparticles

    International Nuclear Information System (INIS)

    Madni, A.; Kashif, P.M.; Nazir, I.; Rehman, M.

    2017-01-01

    Assessment of possible incompatibilities between drug and excipients is an important parameter of preformulation stage during the pharmaceutical product development of active pharmaceutical ingredient (API). The potential physical and chemical interaction among the components of a delivery system can affect the chemical nature, bioavailability, stability, and subsequently therapeutic efficacy of drugs. In this study, ATR-FTIR spectroscopy was employed to investigate the possible intermolecular interaction of Cytarabine with deacetylated chitosan and tripolyphosphate in the resulting physical blends and crosslinked nanoparticulate system. Two different strategies, physical blending and ionotropic gelation, were adopted to prepare binary or tertiary mixtures and nanoparticulate formulation, respectively. The IR spectra of CB showed characteristic peaks at 3438.27 cm-1 (primary amine), 3264.74 cm-1 (hydroxyl group) and 1654.98 cm-1 (C=O stretch in cyclic ring); CS at 3361.47 cm-1 (N-H stretching), 1646.18 cm-1 (C=O of Amide I), 1582.36 cm-1 (C=O of Amide II), and sTPP at 1135.77 cm-1 (P=O). CS-sTPP chemical interaction was confirmed from the shift in the absorption band of carbonyl groups (amide I, II) to 1634.66 cm-1 and 1541.17 cm-1 in blank chitosan nanoparticles, and 1636.87 cm-1, 1543.33 cm-1 in CSNP1 (2:6:1), and at 1646.15 cm-1 and 1557.04 cm-1 in CSNP2 (1:3:1). The characteristic peaks of CB were also present in chitosan formulation with a slight shift in the amino group at 3429.43 cm-1 and 3423.21 cm-1, in the hydroxyl group at 3274.54 cm-1 and 3270.73 cm-1, CSNP1 and CSNP2, respectively. The findings counseled no significant interaction in IR absorption pattern of cytarabine functional groups after encapsulation in CS-sTPP complex, which projected the potential of chitosan nanoparticulate system to entrap cytarabine. (author)

  7. Study of Acoustic Emission and Mechanical Characteristics of Coal Samples under Different Loading Rates

    Directory of Open Access Journals (Sweden)

    Huamin Li

    2015-01-01

    Full Text Available To study the effect of loading rate on mechanical properties and acoustic emission characteristics of coal samples, collected from Sanjiaohe Colliery, the uniaxial compression tests are carried out under various levels of loading rates, including 0.001 mm/s, 0.002 mm/s, and 0.005 mm/s, respectively, using AE-win E1.86 acoustic emission instrument and RMT-150C rock mechanics test system. The results indicate that the loading rate has a strong impact on peak stress and peak strain of coal samples, but the effect of loading rate on elasticity modulus of coal samples is relatively small. When the loading rate increases from 0.001 mm/s to 0.002 mm/s, the peak stress increases from 22.67 MPa to 24.99 MPa, the incremental percentage is 10.23%, and under the same condition the peak strain increases from 0.006191 to 0.007411 and the incremental percentage is 19.71%. Similarly, when the loading rate increases from 0.002 mm/s to 0.005 mm/s, the peak stress increases from 24.99 MPa to 28.01 MPa, the incremental percentage is 12.08%, the peak strain increases from 0.007411 to 0.008203, and the incremental percentage is 10.69%. The relationship between acoustic emission and loading rate presents a positive correlation, and the negative correlation relation has been determined between acoustic emission cumulative counts and loading rate during the rupture process of coal samples.

  8. Heel blood flow during loading and off-loading in bedridden older adults with low and normal ankle-brachial pressure index: a quasi-experimental study.

    Science.gov (United States)

    Masaki, Nami; Sugama, Junko; Okuwa, Mayumi; Inagaki, Misako; Matsuo, Junko; Nakatani, Tosio; Sanada, Hiromi

    2013-07-01

    The purpose of this study was to evaluate the differences in heel blood flow during loading and off-loading in bedridden adults older than 65 years. The patients were divided into three groups based on ankle-brachial pressure index (ABI) and transcutaneous oxygen tension (tcPO₂): (1) patients with an ABI ≥ 0.8 (Group A); (2) patients with an ABI < 0.8 and heel tcPO₂ ≥ 10 mmHg (Group B); and (3) patients with an ABI < 0.8 and heel tcPO₂ < 10 mmHg (Group C). Heel blood flow was monitored using tcPO₂ sensors. Data were collected with the heel (1) suspended above the bed surface (preload), (2) on the bed surface for 30 min (loading), and (3) again suspended above the bed surface for 60 min (off-loading). Heel blood flow during off-loading was assessed using three parameters: oxygen recovery index (ORI), total tcPO₂ for the first 10 min, and change in tcPO₂ after 60 min of off-loading. ORI in Group C (n = 8) was significantly shorter than in Groups A (n = 22) and B (n = 15). Total tcPO₂ for the first 10 min of off-loading in Group C was significantly less than that in Groups A and B. Change in tcPO₂ after 60 min of off-loading in Group C was less than in Group A. Based on these findings, additional preventive care against heel blood flow decrease in older adults with an ABI < 0.8 and heel tcPO₂ < 10 mmHg might be necessary after loading.

  9. Adolescent standing postural response to backpack loads: a randomised controlled experimental study

    Directory of Open Access Journals (Sweden)

    Pirunsan Ubon

    2002-04-01

    Full Text Available Abstract Background Backpack loads produce changes in standing posture when compared with unloaded posture. Although 'poor' unloaded standing posture has been related to spinal pain, there is little evidence of whether, and how much, exposure to posterior load produces injurious effects on spinal tissue. The objective of this study was to describe the effect on adolescent sagittal plane standing posture of different loads and positions of a common design of school backpack. The underlying study aim was to test the appropriateness of two adult 'rules-of-thumb'-that for postural efficiency, backpacks should be worn high on the spine, and loads should be limited to 10% of body weight. Method A randomised controlled experimental study was conducted on 250 adolescents (12–18 years, randomly selected from five South Australian metropolitan high schools. Sagittal view anatomical points were marked on head, neck, shoulder, hip, thigh, knee and ankle. There were nine experimental conditions: combinations of backpack loads (3, 5 or 10% of body weight and positions (backpack centred at T7, T12 or L3. Sagittal plane photographs were taken of unloaded standing posture (baseline, and standing posture under the experimental conditions. Posture was quantified from the x (horizontal coordinate of each anatomical point under each experimental condition. Differences in postural response were described, and differences between conditions were determined using Analysis of Variance models. Results Neither age nor gender was a significant factor when comparing postural response to backpack loads or conditions. Backpacks positioned at T7 produced the largest forward (horizontal displacement at all the anatomical points. The horizontal position of all anatomical points increased linearly with load. Conclusion There is evidence refuting the 'rule-of-thumb' to carry the backpack high on the back. Typical school backpacks should be positioned with the centre at waist or

  10. Parameter studies to determine sensitivity of slug impact loads to properties of core surrounding structures

    International Nuclear Information System (INIS)

    Gvildys, J.

    1985-01-01

    A sensitivity study of the HCDA slug impact response of fast reactor primary containment to properties of core surrounding structures was performed. Parameters such as the strength of the radial shield material, mass, void, and compressibility properties of the gas plenum material, mass of core material, and mass and compressibility properties of the coolant were used as variables to determine the magnitude of the slug impact loads. The response of the reactor primary containment and the partition of energy were also given. A study was also performed using water as coolant to study the difference in slug impact loads

  11. A Categorization Model for Educational Values of the History of Mathematics. An Empirical Study

    Science.gov (United States)

    Wang, Xiao-qin; Qi, Chun-yan; Wang, Ke

    2017-11-01

    There is not a clear consensus on the categorization framework of the educational values of the history of mathematics. By analyzing 20 Chinese teaching cases on integrating the history of mathematics into mathematics teaching based on the relevant literature, this study examined a new categorization framework of the educational values of the history of mathematics by combining the objectives of high school mathematics curriculum in China. This framework includes six dimensions: the harmony of knowledge, the beauty of ideas or methods, the pleasure of inquiries, the improvement of capabilities, the charm of cultures, and the availability of moral education. The results show that this framework better explained the all-educational values of the history of mathematics that all teaching cases showed. Therefore, the framework can guide teachers to better integrate the history of mathematics into teaching.

  12. Esthetic Outcomes of Immediately Loaded Locking Taper Implants in the Anterior Maxilla: A Case Series Study.

    Science.gov (United States)

    Lombardo, Giorgio; Corrocher, Giovanni; Pighi, Jacopo; Mascellaro, Anna; Marincola, Mauro; Nocini, Per Francesco

    2016-06-01

    The purpose of this study was to evaluate the esthetic outcome of single-tooth locking taper connection implants placed in the anterior maxilla following a postextractive nonfunctional loading protocol. This preliminary clinical study involving 16 patients evaluated the results of 21 implants placed in areas with high esthetic value. For each implant the pink esthetic score, white esthetic score, cumulative survival rate, and health status of peri-implant tissues were evaluated. The cumulative survival rate was 100% 2 years after prosthetic loading, and the mean total pink esthetic score/white esthetic score was 16.9 ± 1.14 on a maximum value of 20. There was excellent plaque control in all patients, and inflammation indices were within the norm. Within the limits of this study, this immediate nonfunctional loading protocol seems to be a successful procedure esthetically and for the maintenance of peri-implant soft tissues.

  13. Dietary acid load in early life and bone health in childhood: the Generation R Study.

    Science.gov (United States)

    Garcia, Audry H; Franco, Oscar H; Voortman, Trudy; de Jonge, Ester A L; Gordillo, Noelia G; Jaddoe, Vincent W V; Rivadeneira, Fernando; van den Hooven, Edith H

    2015-12-01

    Dietary contribution to acid-base balance in early life may influence subsequent bone mineralization. Previous studies reported inconsistent results regarding the associations between dietary acid load and bone mass. We examined the associations of dietary acid load in early life with bone health in childhood. In a prospective, multiethnic, population-based cohort study of 2850 children, we estimated dietary acid load as dietary potential renal acid load (dPRAL), based on dietary intakes of calcium, magnesium, phosphorus, potassium, and protein, and as a protein intake to potassium intake ratio (Pro:K) at 1 y of age and in a subgroup at 2 y of age : Bone mineral density, bone mineral content (BMC), area-adjusted BMC, and bone area were assessed by dual-energy X-ray absorptiometry at the median age of 6 y. Data were analyzed by using multivariable linear regression models. After adjusting for relevant maternal and child factors, dietary acid load estimated as either dPRAL or Pro:K ratio was not consistently associated with childhood bone health. Associations did not differ by sex, ethnicity, weight status, or vitamin D supplementation. Only in those children with high protein intake in our population (i.e., >42 g/d), a 1-unit increase in dPRAL (mEq/d) was inversely associated with BMC (difference: -0.32 g; 95% CI: -0.64, -0.01 g). Dietary acid load in early life was not consistently associated with bone health in childhood. Further research is needed to explore the extent to which dietary acid load in later childhood may affect current and future bone health. © 2015 American Society for Nutrition.

  14. Operation window and part-load performance study of a syngas fired gas turbine

    International Nuclear Information System (INIS)

    He, Fen; Li, Zheng; Liu, Pei; Ma, Linwei; Pistikopoulos, Efstratios N.

    2012-01-01

    Integrated coal gasification combined cycle (IGCC) provides a great opportunity for clean utilization of coal while maintaining the advantage of high energy efficiency brought by gas turbines. A challenging problem arising from the integration of an existing gas turbine to an IGCC system is the performance change of the gas turbine due to the shift of fuel from natural gas to synthesis gas, or syngas, mainly consisting of carbon monoxide and hydrogen. Besides the change of base-load performance, which has been extensively studied, the change of part-load performance is also of great significance for the operation of a gas turbine and an IGCC plant. In this paper, a detailed mathematical model of a syngas fired gas turbine is developed to study its part-load performance. A baseline is firstly established using the part-load performance of a natural gas fired gas turbine, then the part-load performance of the gas turbine running with different compositions of syngas is investigated and compared with the baseline. Particularly, the impacts of the variable inlet guide vane, the degree of fuel dilution, and the degree of air bleed are investigated. Results indicate that insufficient cooling of turbine blades and a reduced compressor surge margin are the major factors that constrain the part-load performance of a syngas fired gas turbine. Results also show that air bleed from the compressor can greatly improve the working condition of a syngas fired gas turbine, especially for those fired with low lower heating value syngas. The regulating strategy of a syngas fired gas turbine should also be adjusted in accordance to the changes of part-load performance, and a reduced scope of constant TAT (turbine exhaust temperature) control mode is required.

  15. Letter to the Editor: Electric Vehicle Demand Model for Load Flow Studies

    DEFF Research Database (Denmark)

    Garcia-Valle, Rodrigo; Vlachogiannis, Ioannis (John)

    2009-01-01

    This paper introduces specific and simple model for electric vehicles suitable for load flow studies. The electric vehicles demand system is modelled as PQ bus with stochastic characteristics based on the concept of queuing theory. All appropriate variables of stochastic PQ buses are given...... with closed formulae as a function of charging time. Specific manufacturer model of electric vehicles is used as study case....

  16. History of health studies around nuclear facilities: a methodologival consideration

    International Nuclear Information System (INIS)

    Tokuhata, G.K.; Smith, M.W.

    1981-01-01

    A brief historical review was made of low-level radiation studies for general populations living around nuclear facilities. In addition, technical and methodological problems were identified and discussed which often arise in all epidemiological studies designed to determine the possible health effects of low-level radiation released from nuclear facilities. Need for extremely large populations for prospective cancer studies was discussed, but accompanying ascertainment difficulties were also emphasized. More epidemiological studies are needed to provide adequate assessment of the potential health hazards of nuclear facilities

  17. Experimental study on the response characteristics of coal permeability to pore pressure under loading and unloading conditions

    Science.gov (United States)

    Ye, Zhiwei; Zhang, Lei; Hao, Dingyi; Zhang, Cun; Wang, Chen

    2017-10-01

    In order to study the response characteristics of coal permeability to pore pressure, seepage experiments under different simulated in situ stresses on loading and unloading paths are carried out using the self-developed Gas Flow and Displacement Testing Apparatus (GFDTA) system. Based on the analysis of the experimental data, the relationship between average pore pressure and permeability is found to basically obey the function distribution of a two degree polynomial. In this paper, two aspects of the relationship between permeability and pore pressure are explained: the Klinbenberg effect and expansion, and the penetration of the initial fracture. Under low pore pressure, the decrease in the Klinbenberg effect is the main reason for the decrease in permeability with increased pore pressure. Under relatively high pore pressure, the increase in pore pressure leads to the initial fracture expansion and penetration of the coal sample, which causes an increase in permeability. In order to evaluate the sensitivity of the permeability response to pore pressure changes, the permeability dispersion and pore pressure sensitivity coefficients are defined. After the sensitivity analysis, it was concluded that the loading history changed the fracture structure of the original coal sample and reduced its permeability sensitivity to pore pressure. Under low pore pressure, the Klinbenberg effect is the reason for the decrease in pore pressure sensitivity. Lastly, the permeability-pore pressure relationship is divided into three stages to describe the different response characteristics individually.

  18. Study on the reactivity behavior partially loaded reactor cores using SIMULATE-3

    International Nuclear Information System (INIS)

    Holzer, Robert; Zeitz, Andreas; Grimminger, Werner; Lubczyk, Tobias

    2009-01-01

    The reactor core design for the NPP Gundremmingen unit B and C is performed since several years using the validated 3D reactor core calculation program SIMULATE-3. The authors describe a special application of the program to study the reactivity for different partial core loadings. Based on the comparison with results of the program CASMO-4 the program SIMULATE-3 was validated for the calculation of partially loaded reactor cores. For the planned reactor operation in NPP Gundremmingen using new MOX fuel elements the reactivity behavior was studied with respect to the KTA-Code requirements.

  19. Empowering Students through History: "The Giver" as a Metaphor and Preparation for Studying History in the Secondary Classroom

    Science.gov (United States)

    Brugar, Kristy A.

    2012-01-01

    Students sometimes resist the history lessons their teachers try to impart; challenging the purpose and relevance of the information being shared. However, reading "The Giver" can help to bridge the gap between students accepting and rejecting the lessons of history while learning to value the skills such as citizenship and awareness associated…

  20. A History of Study Skills: Not Hot, but Not Forgotten

    Science.gov (United States)

    Richardson, Judy S.; Robnolt, Valerie J.; Rhodes, Joan A.

    2010-01-01

    Study skills were an early and important topic in reading; however, since the 1970s, they have received relatively little research attention. The authors systematically analyzed the research conducted on study skills from 1900 to the present. Several themes emerged including: (a) motivation and affect; (b) activities described; (c) metacognition;…

  1. Reliability-based load and resistance factor design for piping: an exploratory case study

    International Nuclear Information System (INIS)

    Gupta, Abhinav; Choi, Byounghoan

    2003-01-01

    This paper presents an exploratory case study on the application of Load and Resistance Factor Design (LRFD) approach to the Section III of ASME Boiler and Pressure Vessel code for piping design. The failure criterion for defining the performance function is considered as plastic instability. Presently used design equation is calibrated by evaluating the minimum reliability levels associated with it. If the target reliability in the LRFD approach is same as that evaluated for the presently used design equation, it is shown that the total safety factors for the two design equations are identical. It is observed that the load and resistance factors are not dependent upon the diameter to thickness ratio. A sensitivity analysis is also conducted to study the variations in the load and resistance factors due to changes in (a) coefficients of variation for pressure, moment, and ultimate stress, (b) ratio of mean design pressure to mean design moment, (c) distribution types used for characterizing the random variables, and (d) statistical correlation between random variables. It is observed that characterization of random variables by log-normal distribution is reasonable. Consideration of statistical correlation between the ultimate stress and section modulus gives higher values of the load factor for pressure but lower value for the moment than the corresponding values obtained by considering the variables to be uncorrelated. Since the effect of statistical correlation on the load and resistance factors is relatively insignificant for target reliability values of practical interest, the effect of correlated variables may be neglected

  2. Antimicrobial activity Study of triclosan-loaded WBPU on Proteus mirabilis in vitro.

    Science.gov (United States)

    Tian, Ye; Jian, Zhongyu; Wang, Jianzhong; He, Wei; Liu, Qinyu; Wang, Kunjie; Li, Hong; Tan, Hong

    2017-04-01

    To evaluate the antimicrobial activity study of triclosan-loaded waterborne polyurethanes (WBPU) on Proteus mirabilis in vitro. Inhibition zone assays on petri plates with triclosan-loaded WBPU samples were used to test its antimicrobial activity on Proteus mirabilis. Models of the catheterized bladder supplied with artificial urine infected with Proteus mirabilis were employed to confirm the antimicrobial activity of triclosan-loaded WBPU. Bacteria colony counting, pH of the residual urine at each time point and catheter blockage time were recorded. Confocal laser scanning microscopy, scanning electron microscopy and encrustation deposits dry weighing were used for evaluating the biofilm formation. Inhibition zones formed in the triclosan-loaded WBPU groups in a dose-response manner (the radius for samples with 1, 0.1 and 0.01 mg triclosan were 9.93 ± 1.08, 6.07 ± 0.54 and 2.47 ± 0.25 mm, P Proteus mirabilis biofilm formation (33.9 ± 13.9 mg vs. 1.4 ± 1.5 mg, P = 0.016). Triclosan-loaded WBPU significantly inhibited Proteus mirabilis' growth and biofilm formation, indicating the promising antibacterial effects on Proteus mirabilis in vitro. Further efforts are under way that involves coating the material onto the urinary catheters and in vivo studies.

  3. A Model of Microteaching Lesson Study Implementation in the Prospective History Teacher Education

    Science.gov (United States)

    Utami, Indah Wahyu Puji; Mashuri; Nafi'ah, Ulfatun

    2016-01-01

    Microteaching lesson study is a model to improve prospective teacher quality by incorporating several element of microteaching and lesson study. This study concern on the implementation of microteaching lesson study in prospective history teacher education. Microteaching lesson study model implemented in this study consist of three stages: plan,…

  4. Minorities in Islamic History: An Analytical Study of Four Documents ...

    African Journals Online (AJOL)

    Journal for Islamic Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 20 (2000) >. Log in or Register to get access to full text downloads.

  5. Language ability of children with and without a history of stuttering: a longitudinal cohort study.

    Science.gov (United States)

    Watts, Amy; Eadie, Patricia; Block, Susan; Mensah, Fiona; Reilly, Sheena

    2015-02-01

    This study aims to determine whether the communication and language skills of children who have a history of stuttering are different from children who do not have a history of stuttering at ages 2-5 years. This study utilizes data from the Early Language in Victoria Study (ELVS), a longitudinal study with a community sample of 1910 children recruited in Melbourne, Australia, as well as a concurrent study examining the onset and progression of stuttering. Participants with a history of stuttering (n = 181) and a control group without a history of stuttering (n = 1438) were identified according to the established protocol of these two existing studies. The stuttering group scored higher than the non-stuttering group on all of the communication and language outcomes measured. The group differences were statistically significant on four of the seven measures and these findings were maintained when potentially confounding factors were controlled for. Importantly, the children with a history of stuttering, as a group, and the control group without a history of stuttering demonstrated developmentally-appropriate early communication and language skills.

  6. Parental history of psychiatric diagnoses and unipolar depression: a Danish National Register-based cohort study.

    Science.gov (United States)

    Musliner, K L; Trabjerg, B B; Waltoft, B L; Laursen, T M; Mortensen, P B; Zandi, P P; Munk-Olsen, T

    2015-10-01

    Depression is known to run in families, but the effects of parental history of other psychiatric diagnoses on depression rates are less well studied. Few studies have examined the impact of parental psychopathology on depression rates in older age groups. We established a population-based cohort including all individuals born in Denmark after 1954 and alive on their 10th birthday (N = 29 76 264). Exposure variables were maternal and paternal history of schizophrenia, bipolar disorder, depression, anxiety or 'other' psychiatric diagnoses. Incidence rate ratios (IRRs) were estimated using Poisson regressions. Parental history of any psychiatric diagnosis increased incidence rates of outpatient (maternal: IRR 1.88, p history. IRRs for parental history of non-affective disorders remained relatively stable across age groups, while IRRs for parental affective disorders (unipolar or bipolar) decreased with age from 2.29-3.96 in the youngest age group to 1.53-1.90 in the oldest group. IRR estimates for all parental diagnoses were similar among individuals aged ⩾41 years (IRR range 1.51-1.90). Parental history of any psychiatric diagnosis is associated with increased incidence rates of unipolar depression. In younger age groups, parental history of affective diagnoses is more strongly associated with rates of unipolar depression than non-affective diagnoses; however, this distinction disappears after age 40, suggesting that parental psychopathology in general, rather than any one disorder, confers risk for depression in middle life.

  7. Study of nonpoint source nutrient loading in the Patuxent River basin, Maryland

    Science.gov (United States)

    Preston, S.D.

    1997-01-01

    Study of nonpoint-source (NPS) nutrient loading in Maryland has focused on the Patuxent watershed because of its importance and representativeness of conditions in the State. Evaluation of NPS nutrient loading has been comprehensive and has included long-term monitoring, detailed watershed modeling, and synoptic sampling studies. A large amount of information has been compiled for the watershed and that information is being used to identify primary controls and efficient management strategies for NPS nutrient loading. Results of the Patuxent NPS study have identified spatial trends in water quality that appear to be related to basin charcteristics such as land use, physiography, andgeology. Evaluation of the data compiled by the study components is continuing and is expected to provide more detailed assessments of the reasons for spatial trends. In particular, ongoing evaluation of the watershed model output is expected to provide detailed information on the relative importance of nutrient sources and transport pathways across the entire watershed. Planned future directions of NPS evaluation in the State of Maryland include continued study of water quality in the Patuxent watershed and a shift in emphasis to a statewide approach. Eventually, the statewide approach will become the primary approach usedby the State to evaluate NPS loading. The information gained in the Patuxent study and the tools developed will represent valuable assets indeveloping the statewide NPS assessment program.

  8. STUDY ON THE CROSS WAR FOR INTERNALIZING VALUES OF TOLERANCE IN HISTORY LEARNING

    Directory of Open Access Journals (Sweden)

    Jossapat Hendra Prijanto

    2017-05-01

    Full Text Available As we know that history is series of events that occurred which its presence must be motivated by specific causes. History does not appear immediately and stand alone without anyone arousing it. It can be said that history has a prologue and epilogue, because not all of the events that happened in the past can be recorded by history. In this topic being discussed, a crusade became the reality of the history of mankind, which had taken more or less for two hundred years. The War was the greatest conflict of two religions in the world which was between Islam that held the power at that time in part of Europe, North Africa and Asia, against the followers of Christianity who tried to seize the city of Jerusalem, which at that time ruled by Islam, the postscript is a holy city for them. Islam and Christianity are the major religions in the world that their religious teachings heavily loaded with the values of peace, tolerance and social relationships. Both in the Qur'an and Gospel, there are a lot of passages of calls for tolerance, peace and social relations. This creates a question, why the war should happen, in terms of Islam encountered in a call for dialogue with the People of the Book in a good way, as well as in Christianity which is expressed as a neighbor. Islam also considers that the Christians are a people who are closest to the Islamic ummah, and both religions actually are brothers, free from hostility and enmity.

  9. Fatigue life assessment of thin-walled welded joints under non-proportional load-time histories by the shear stress rate integral approach

    Directory of Open Access Journals (Sweden)

    A. Bolchoun

    2016-10-01

    Full Text Available Fatigue life tests under constant and variable amplitude loadings were performed on the tube-tube thin-walled welded specimens made of magnesium (AZ31 and AZ61 alloys. The tests included pure axial, pure torsional and combined in-phase and out-of-phase loadings with the load ratio  RR " ", " " 1  . For the tests with variable amplitude loads a Gaußdistributed loading spectrum with S L 4 5 10  cycles was used. Since magnesium welds show a fatigue life reduction under out-of-phase loads, a stress-based method, which takes this behavior into account, is proposed. The out-of-phase loading results in rotating shear stress vectors in the section planes, which are not orthogonal to the surface. This fact is used in order to provide an out-of-phase measure of the load. This measure is computed as an area covered by the shear stress vectors in all planes over a certain time interval, its computation involves the shear stress and the shear stress rate vectors in the individual planes. Fatigue life evaluation for the variable amplitudes loadings is performed using the Palmgren-Miner linear damage accumulation, whereas the total damage of every cycle is split up into two components: the amplitude component and the out-of-phase component. In order to compute the two components a modification of the rainflow counting method, which keeps track of the time intervals, where the cycles occur, must be used. The proposed method also takes into account different slopes of the pure axial and the pure torsional Wöhler-line by means of a Wöhler-line interpolation for combined loadings

  10. History and actual state of study on thorotrast delayed injuries

    International Nuclear Information System (INIS)

    Mori, Takesaburo

    1974-01-01

    Disorders caused by thorotrast have been paid attention recently from aspect of relationship of radiation delayed injuries and it will be called into question in future. It is regarded as important as one of the basic data of ultra-uranium element disorders which induced alpha disintegration. Reports from each country such as epidemiological study, clinical and pathohistological examinations presented at the third international meeting on the toxity of thorotrast held in April of 1973 were given an outline. Being too late in study of thorotrast injuries in Japan as compared with that in Europe and America each country was pointed out. (Serizawa, K.)

  11. A Study on Load Following Operation Strategy to Minimize Boric-acid Adjustment

    International Nuclear Information System (INIS)

    Yoo, Jae Woon

    1997-02-01

    Applicability of the MSHIM control strategy, which has been developed by Westinghouse and characterized by elimination of the adjustment to the boron concentration during load maneuvering, to 1300MWe KNGR Cycle-1 is examined by simulation based on one-dimensional transient analyses code, ONED94, under the conditions of relatively large xenon worth and high amplitude of xenon oscillation. CASMO-3/MASTER code system is used to generate the ONED94 model. A processing code, which is referred to as MAS2ONED, is also developed to transform the MASTER calculation results to ONED94 cross section library. The three types of power maneuvering, daily maneuvering, extended weekend load follow, and spinning reserve capacity are simulated to evaluate the capability of the selected load follow technology, by using ONED94 code. By showing that the calculated total peaking factor is maintained below safety limit, it is proved that load follow operation without boron adjustment is feasible with simple control rod motion only. It is expected that the results of this study, such as control rod parameters could give a contribution to the development of load following technology in our country. The developed process code could be utilized in the another simulation of power maneuver in the future

  12. Voltage control of a variable speed wind turbine connected to an isolated load: Experimental study

    International Nuclear Information System (INIS)

    Masmoudi, Abdelkarim; Krichen, Lotfi; Ouali, Abderrazak

    2012-01-01

    Highlights: ► We develop an experimental test bench of a wind energy conversion system. ► A DC motor is emulating a variable speed wind turbine using a DS1104 card. ► The production unit is supplying a three-phase load. ► A voltage control is established in order to regulate the DC bus voltage and the line-to-line voltages. - Abstract: This study is interested in the development of an experimental test bench of an autonomous wind energy conversion system (WECS) based on a permanent magnet synchronous generator (PMSG). After the description of the test bench, the elements constituting the WECS are presented. Then, a real time model implemented under a digital signal processor (DSP) system is established. The first objective of this work is to validate the functionality of the test bench leading to experiment some principles developed in theory. The second objective is to control the load connection voltages and the DC bus voltage. For the first control, two resonant controllers are used and for the second one, a dump load, connected to the DC bus, offers the possibility to maintain a balance between production and consumption in spite of wind fluctuations and load variations. The experimental results show the effectiveness of the test bench trying out in real time the behavior of a WECS supplying an isolated load.

  13. Experimental study on the Kaiser effect of AE under multiaxial loading in granite

    International Nuclear Information System (INIS)

    Watanabe, Hidehiko; Hiroi, Takehiro

    2012-01-01

    Knowledge of the in-situ stresses is essential for underground excavation design, particularly in evaluating stability of excavation. Acoustic Emission method, which utilizes the Kaiser effect, is one of the simple methods for measuring in-situ stresses. Experiments on the Kaiser effect has been carried out under uniaxial compression and triaxial compression (σ 1 > σ 2 = σ 3 ), but has not been carried out under the three different principal stresses (σ 1 > σ 2 > σ 3 ). In this study, we performed two experiments on the Kaiser effect under multiaxial loading, using a hollow cylindrical granite specimen. The rapidly increasing point of cumulative AE event count was determined as the peak point of AE event count rate increment (AERI). The main results are summarized as follows. (1) In the case of the cyclic incremental σ 1 loading under σ 2 ≠σ 3 , the large peak point of AERI appeared just before the pre-stress level. And as more stresses prior to just before the peak point were estimated, the estimated error showed a tendency to increase. (2) In the case of re-loading under the lower σ 2 and σ 3 more than pre-loading, the estimated stresses using the three peak points of AERI corresponded to the pre-differential stresses (σ 1 -σ 2 ), (σ 1 -σ 3 ) and pre-axial stress σ 1 . The magnitudes of the three principal stresses were estimated under multiaxial loading from the Kaiser effect, using only one specimen. (author)

  14. Experimental Study for Structural Behaviour of Precast Lightweight Panel (PLP) Under Flexural Load

    Science.gov (United States)

    Goh, W. I.; Mohamad, N.; Tay, Y. L.; Rahim, N. H. A.; Jhatial, A. A.; Samad, A. A. A.; Abdullah, R.

    2017-06-01

    Precast lightweight concrete slab is first fabricated in workshop or industrial before construction and then transported to site and installed by skilled labour. It can reduce construction time by minimizing user delay and time for cast-in-situ to increase workability and efficiency. is environmental friendly and helps in resource reduction. Although the foamed concrete has low compressive strength compared to normal weight concrete but it has excellent thermal insulation and sound absorption. It is environmental friendly and helps in resource reduction. To determine the material properties of foamed concrete, nine cubes and six cylindrical specimens were fabricated and the results were recorded. In this study, structural behaviour of precast lightweight panel (PLP) with dry density of 1800 kg/m3 was tested under flexural load. The results were recorded and analysed in terms of ultimate load, crack pattern, load-deflection profiles and strain distribution. Linear Voltage Displacement Transducers (LVDT) and strain gauges were used to determine the deflection and strain distribution of PLP. The theoretical and experimental ultimate load of PLP was analysed and recorded to be 70 and 62 kN respectively, having a difference of 12.9%. Based on the results, it can be observed that PLP can resist the adequate loading. Thus, it can be used in precast industry for construction purposes.

  15. Antimicrobial, Mechanical and Thermal Studies of Silver Particle-Loaded Polyurethane

    Directory of Open Access Journals (Sweden)

    Deepen Paul

    2013-12-01

    Full Text Available Silver-particle-incorporated polyurethane films were evaluated for antimicrobial activity towards two different bacteria: Escherichia coli (E. coli and Staphylococcus aureus (S. aureus. Distributed silver particles sourced from silver nitrate, silver lactate and preformed silver nanoparticles were mixed with polyurethane (PU and variously characterized by field emission scanning electron microscopy (FESEM, fourier transform infra-red (FTIR spectroscopy, X-ray diffraction (XRD and contact angle measurement. Antibacterial activity against E.coli was confirmed for films loaded with 10% (w/w AgNO3, 1% and 10% (w/w Ag lactate and preformed Ag nanoparticles. All were active against S. aureus, but Ag nanoparticles loaded with PU had a minor effect. The apparent antibacterial performance of Ag lactate-loaded PU is better than other Ag ion-loaded films, revealed from the zone of inhibition study. The better performance of silver lactate-loaded PU was the likely result of a porous PU structure. FESEM and FTIR indicated direct interaction of silver with the PU backbone, and XRD patterns confirmed that face-centred cubic-type silver, representative of Ag metal, was present. Young’s modulus, tensile strength and the hardness of silver containing PU films were not adversely affected and possibly marginally increased with silver incorporation. Dynamic mechanical analysis (DMA indicated greater thermal stability.

  16. Effects of occlusal inclination and loading on mandibular bone remodeling: a finite element study.

    Science.gov (United States)

    Rungsiyakull, Chaiy; Rungsiyakull, Pimdeun; Li, Qing; Li, Wei; Swain, Michael

    2011-01-01

    To provide a preliminary understanding of the biomechanics with respect to the effect of cusp inclination and occlusal loading on the mandibular bone remodeling. Three different cusp inclinations (0, 10, and 30 degrees) of a ceramic crown and different occlusal loading locations (central fossa and 1- and 2-mm offsets horizontally) were taken into account to explore the stresses and strains transferred from the crown to the surrounding dental bone through the implant. A strain energy density obtained from two-dimensional plane-strain finite element analysis was used as the mechanical stimulus to drive cancellous and cortical bone remodeling in a buccolingual mandibular section. Different ceramic cusp inclinations had a significant effect on bone remodeling responses in terms of the change in the average peri-implant bone density and overall stability. The remodeling rate was relatively high in the first few months of loading and gradually decreased until reaching its equilibrium. A larger cusp inclination and horizontal offset (eg, 30 degrees and 2-mm offset) led to a higher bone remodeling rate and greater interfacial stress. The dental implant superstructure design (in terms of cusp inclination and loading location) determines the load transmission pattern and thus largely affects bone remodeling activities. Although the design with a lower cusp inclination recommended in previous studies may reduce damage and fracture failure, it could, to a certain extent, compromise bone engagement and long-term stability.

  17. Recent history of Saker Falcon studies in Mongolia

    Science.gov (United States)

    Ellis, D.H.

    2001-01-01

    This report clarifies recent studies on the saker falcon in Mongolia. In the last five years, three museum studies appeared on the Altay falcon (is it a gyrfalcon, saker or separate species). These showed that all of the most distinct Central Asian summer specimens were from only two mountain ranges. However, there is a continuum between sakers and Altay falcons and the two should be considered synonymous. Of field studies focused on the saker in Mongolia, the first was conducted by Baumgart in the 1970s. The next (my own) began in 1994 with a Mongolia-wide study of the nesting ecology of the species. From that study, we now have over 150 breeding territories with over 200 eyries described. Resulting publications dealt with reproductive performance of the falcons and unusual breeding situations. Not only were many nests in odd situations, many were also composed mainly of manmade materials. We found that birds sometimes became entangled in twine and cloth in such nests and either died or would have died without our intervention. Our work also led to observations of novel social behavior including the first documentation of siblicide for any falcon and the description of a new falcon display, splayed-toes-flight. Aware that saker populations in Kazakhstan and elsewhere were plummeting due to over harvest for falconry and seeing a growing harvest in Mongolia, in 1997, we began efforts to build artificial eyries for the falcons. To date, over 150 artificial eyries have been created. In 1998, there was a great expansion of saker field work after the National Avian Research Center (NARC) of the United Arab Emirates became directly involved in hiring Mongol students and scientists. Those efforts resulted in an immediate estimate of the breeding population. Continuing work promises to provide good information on home range, food habits, productivity and other topics.

  18. The study of virus structure and function: a personal history

    Science.gov (United States)

    Rossmann, Michael G.

    2014-09-01

    I describe my gradually evolving role as a scientist from my birth in Frankfurt (Germany) to my education in the UK, my post-doc years and my experiences as an independent investigator at Purdue University1. I discuss the significance of my post-doctoral work in Minnesota where I had my first encounter with an electronic computer and subsequently in Cambridge where I participated in the first structure determination of proteins. After six years back in England my family moved to Indiana (USA) where my home remains to this day. At Purdue University I first studied the structure of enzymes and in the process I discovered the organization and slow evolution of protein domains, each with a specific function. With this success I started what had been on my mind already for a long time, namely the structural analysis of viruses. Initially we studied plant viruses but then switched to small RNA animal viruses, discovering that some plant and animal RNA viruses have closely similar structures and therefore presumably had a common evolutionary origin. Next I became interested in somewhat larger viruses that had lipid membrane envelopes. In turn that has led to the study of very large dsDNA viruses as big as small bacteria as well as studies of bacterial viruses that require complex molecular motors for different parts of their life cycle. While developing crystallographic techniques for the study of viruses it has become progressively more apparent that electron microscopy is an important new tool that is likely to eclipse x-ray crystallography in the next decade.

  19. A Comparative Study of the Behaviour of Five Dense Glass Materials Under Shock Loading Conditions

    Science.gov (United States)

    Radford, Darren D.; Proud, William G.; Field, John E.

    2001-06-01

    Previous work at the Cavendish Laboratory on the properties of glasses under shock loading has demonstrated that the material response is highly dependent upon the composition of the glass. The shock response of glass materials with an open structure, such as borosilicate, exhibits a ramping behaviour in the longitudinal stress histories due to structural collapse. Glass materials with a “filled” microstructure, as in the case of Type-D, Extra Dense Flint (DEDF) do not exhibit a ramping behaviour and behave in a manner similar to polycrystalline ceramics [1]. The current investigation compares the behaviour of five such glasses (SF15, DEDF, LACA, SF57 and DEDF-927210) under shock loading conditions. It is observed that slight changes in material composition can have a large affect on the inelastic behaviour. Principal Hugoniot and shear strength data are presented for all of the materials for pressures ranging from 2 to 14 GPa. Evidence of the so-called failure-front [2] is presented via lateral stress histories measured using manganin stress gauges and confirmed with high-speed photography. 1. Bourne, N.K., Millett, J.C.F., and Field, J.E., “On the strength of shocked glasses” Proc. R. Soc. Lond. A 455 (1999) 1275-1282 2. Brar, N.S., “Failure Waves in Glass and Ceramics Under Shock Compression”, in "Shock Compression of Condensed Matter 1999", ed. M.D. Furnish, L.C. Chhabildas, and R.S. Hixson, American Institute of Physics, Woodbury, New York, (1999) 601-606

  20. Study of automatic boat loading unit and horizontal sintering process of uranium dioxide pellet

    International Nuclear Information System (INIS)

    He Zhongjing; Chen Yu; Yao Dengfeng; Wang Youliang; Shu Binhua; Wu Genjiu

    2014-01-01

    Sintering process is a key process for the manufacture of nuclear fuel UO_2 pellet. In our factory, the continuous high temperature sintering furnace is used for sintering process. During the sintering of green pellets, the furnace, the boat and the accumulation way can influence the quality of the final product. In this text, on the basis of early process research, The automatic loading boat Unit and horizontal sintering process is studied successively. The results show that the physical and chemical properties of the products manufactured by automatic loading boat unit and horizontal sintering process can meet the technique requirements completely, and this system is reliable and continuous. (authors)

  1. Experimental study of plasma energy transfer and material erosion under ELM-like heat loads

    Energy Technology Data Exchange (ETDEWEB)

    Garkusha, I.E., E-mail: garkusha@ipp.kharkov.u [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine); Makhlaj, V.A.; Chebotarev, V.V. [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine); Landman, I. [Forschungszentrum Karlsruhe, IHM, 76021 Karlsruhe (Germany); Tereshin, V.I.; Aksenov, N.N.; Bandura, A.N. [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine)

    2009-06-15

    Main features of plasma-surface interaction and energy transfer to tokamak plasma facing components are studied at different heat loads in ELM simulation experiments with the plasma gun QSPA Kh-50. Repetitive plasma exposures of tungsten, graphite and different combined W-C targets were performed at the pulse duration of 0.25 ms and the heat loads varied in the range 0.2-2.5 MJ/m{sup 2}. The onset of vapor shield in front of the surface was investigated. The evaporation is immediately followed by a saturation of surface heat load if further increasing the impact energy. The presence of graphite essentially decreases the heat flux to the nearby tungsten surface, which is due to the carbon vapor shield. Droplet splashing at the tungsten surface and formation of hot spots on the graphite surface are discussed.

  2. Experimental study of plasma energy transfer and material erosion under ELM-like heat loads

    International Nuclear Information System (INIS)

    Garkusha, I.E.; Makhlaj, V.A.; Chebotarev, V.V.; Landman, I.; Tereshin, V.I.; Aksenov, N.N.; Bandura, A.N.

    2009-01-01

    Main features of plasma-surface interaction and energy transfer to tokamak plasma facing components are studied at different heat loads in ELM simulation experiments with the plasma gun QSPA Kh-50. Repetitive plasma exposures of tungsten, graphite and different combined W-C targets were performed at the pulse duration of 0.25 ms and the heat loads varied in the range 0.2-2.5 MJ/m 2 . The onset of vapor shield in front of the surface was investigated. The evaporation is immediately followed by a saturation of surface heat load if further increasing the impact energy. The presence of graphite essentially decreases the heat flux to the nearby tungsten surface, which is due to the carbon vapor shield. Droplet splashing at the tungsten surface and formation of hot spots on the graphite surface are discussed.

  3. A study on fire design accidental loads for aluminum safety helidecks

    Directory of Open Access Journals (Sweden)

    Sang Jin Kim

    2016-11-01

    Full Text Available The helideck structure must satisfy the safety requirements associated with various environmental and accidental loads. Especially, there have been a number of fire accidents offshore due to helicopter collision (take-off and/or landing in recent decades. To prevent further accidents, a substantial amount of effort has been directed toward the management of fire in the safety design of offshore helidecks. The aims of this study are to introduce and apply a procedure for quantitative risk assessment and management of fires by defining the fire loads with an applied example. The frequency of helicopter accidents are considered, and design accidental levels are applied. The proposed procedures for determining design fire loads can be efficiently applied in offshore helideck development projects.

  4. Synthesis of curcumin-loaded chitosan phosphate nanoparticle and study of its cytotoxicity and antimicrobial activity.

    Science.gov (United States)

    Deka, C; Aidew, L; Devi, N; Buragohain, A K; Kakati, D K

    2016-11-01

    Curcumin has acquired an important position in the treatment of various diseases. But its use, as a chemotherapeutic agent, is limited due to its low water solubility, poor bioavailability, and its sensitive nature at the physiological pH. To overcome this, curcumin was loaded into chitosan phosphate nanoparticles (CPNs). The loading efficiency was found to be 84%. DLS studies revealed the average particle size of CPNs and curcumin-loaded CPNs as 53 and 91 nm, respectively, and TEM results supplemented these values. A sustained release pattern was noticed and the amount of curcumin released in acidic pH was higher than at physiological pH. The curcumin nanoformulation exhibited proficient activity against both Gram-positive and Gram-negative bacteria as well as fungus. Cytocompatibility of the nanoformulations against peripheral blood mononuclear cells (PBMCs) and murine monocyte-macrophage cell line was confirmed by incubating with PBMCs and murine monocyte-macrophage cell line.

  5. Preparation of berbamine loaded chitosan-agarose microspheres and in vitro release study

    Directory of Open Access Journals (Sweden)

    Zhang Hu

    2012-01-01

    Full Text Available Berbamine loaded chitosan-agarose microspheres were prepared using a water-in-oil emulsion technique. Optimum preparing parameters were determined by orthogonal experiments as follows: ratio of berbamine to chitosan (w/w is 1:10; percentage of emulsifier (span 80, v/v is 6%; volume of glutaraldehyde is 2 mL; and reaction temperature is 70 ºC. Under these optimal conditions, the encapsulation efficiency and loading capacity of microspheres are 84.57% and 8.44%, respectively. The swelling tests showed that the microspheres possessed higher swelling ratio at pH 7.4 than at pH 1.2. FTIR indicated that berbamine had been successfully loaded in the chitosan-agarose microspheres by physical entrapment. In vitro release studies showed that berbamine was released from microspheres in a significantly sustained fashion.

  6. Novel method to dynamically load cells in 3D-hydrogels culture for blast injury studies

    Science.gov (United States)

    Sory, David R.; Areias, Anabela C.; Overby, Darryl R.; Proud, William G.

    2017-01-01

    For at least a century explosive devices have been one of the most important causes of injuries in military conflicts as well as in terrorist attacks. Although significant experimental and modelling efforts have been focussed on blast injuries at the organ or tissue level, few studies have investigated the mechanisms of blast injuries at the cellular level. This paper introduces an in vitro method compatible with living cells to examine the effects of high stress and short-duration pulses relevant to blast loadings and blunt trauma. The experimental phase involves high strain-rate axial compression of cylindrical specimens within an hermetically sealed chamber made of biocompatible polymer. Numerical simulations were performed in order to verify the experimental loading conditions and to characterize the loading path within the sample. A proof of concept is presented so as to establish a new window to address fundamental questions regarding blast injury at the cellular level.

  7. Bone reactions adjacent to titanium implants subjected to static load. A study in the dog (I)

    DEFF Research Database (Denmark)

    Gotfredsen, K; Berglundh, T; Lindhe, J

    2001-01-01

    The aim of the study was to evaluate the effect of lateral static load induced by an expansion force on the bone/implant interface and adjacent peri-implant bone. In 3 beagle dogs, the 2nd, 3rd and 4th mandibular premolars were extracted bilaterally. Twelve weeks later 8 implants of the ITI Dental...... Implant System were placed in each dog. Crowns connected in pairs were screwed on the implants 12 weeks after implant installation. The connected crowns contained an orthodontic expansion screw yielding 4 loading units in each dog. Clinical registrations, standardized radiographs and fluorochrome labeling...... were carried out during the 24-week loading period. Biopsies were harvested and processed for ground sectioning. The sections were subjected to histological examination. No evident marginal bone loss was observed at either test or control sites. The bone density and the mineralized bone-to-implant...

  8. A study on contraction of pneumatic artificial muscle (PAM) for load-lifting

    Science.gov (United States)

    Najmuddin, W. S. W. A.; Mustaffa, M. T.

    2017-10-01

    Pneumatic Artificial Muscles (PAMs) have been known for its wide application in various aspects of industrial automation and robotic equipments. Many advantages in terms of high power-to-volume ratio, high power-to-weight ratio, stick-slip-free operation and high degree of safety offer by PAM compare to traditional actuators. However, behind this benefits lie a limitation of significant compatibility of PAM mechanism which have to be considered so as to fully understand how the PAM works during load-lifting. In this study, the mesh suitability experiment and the effect of force load on PAM contraction experiment have been carried out. PAM is constructed and compatibility of bladder and the braided mesh to produce uniform expansion is investigated. Moreover, the first experimental result of finding compatibility is used to verify the contraction value under various loads.

  9. Case studies in cholera: lessons in medical history and science.

    Science.gov (United States)

    Kavic, S. M.; Frehm, E. J.; Segal, A. S.

    1999-01-01

    Cholera, a prototypical secretory diarrheal disease, is an ancient scourge that has both wrought great suffering and taught many valuable lessons, from basic sanitation to molecular signal transduction. Victims experience the voluminous loss of bicarbonate-rich isotonic saline at a rate that may lead to hypovolemic shock, metabolic acidosis, and death within afew hours. Intravenous solution therapy as we know it was first developed in an attempt to provide life-saving volume replacement for cholera patients. Breakthroughs in epithelial membrane transport physiology, such as the discovery of sugar and salt cotransport, have paved the way for oral replacement therapy in areas of the world where intravenous replacement is not readily available. In addition, the discovery of the cholera toxin has yielded vital information about toxigenic infectious diseases, providing a framework in which to study fundamental elements of intracellular signal transduction pathways, such as G-proteins. Cholera may even shed light on the evolution and pathophysiology of cystic fibrosis, the most commonly inherited disease among Caucasians. The goal of this paper is to review, using case studies, some of the lessons learned from cholera throughout the ages, acknowledging those pioneers whose seminal work led to our understanding of many basic concepts in medical epidemiology, microbiology, physiology, and therapeutics. PMID:11138935

  10. Is the internal training load different between starters and nonstarters volleyball players submitted to the same external load training? A case study

    Directory of Open Access Journals (Sweden)

    Thiago Andrade Goulart Horta

    2017-11-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2017v19n4p395   The same training stimulus can provide different physiological adaptations for athletes of the same team. Thus, the aim of this study was to analyze and compare the load training of starters and nonstarters players, athletes of a men’s volleyball team at different times of the season. The sample consisted of fifteen men’s volleyball superleague athletes who were divided into two groups of starters and nonstarters players. The training load of the ten weeks of the team’s preparation period for the main championship season in which no games were performed was selected for the study. The method of subjective perceived of effort (session-RPE proposed by Foster et al. (2001 was used to quantify the training load. The group of starters players had higher total weekly training load (TWTL and RPE values in the average of the ten weeks of training (p<0.05. Higher TWTL values for starters players in the preparatory and pre-competitive period compared to nonstarters players was also demonstrated (p<0.05. When different weeks were analyzed separately, weeks three and seven presented higher TWTL and RPE values for starters players compared with nonstarters players (p<0.05. The results presented in this study showed that starters players showed greater internal training load compared to nonstarters players.

  11. Experimental study on the structural and mooring loads of the WEPTOS Wave Energy Converter

    DEFF Research Database (Denmark)

    Pecher, Arthur Francois Serge; Kofoed, Jens Peter

    This report presents the results of an experimental study that was performed on small scale model that was a replication of the full-scale Weptos WEC intended for DanWEC. During these tests, after optimising the mooring solution, various loads were measured that occur in the structure and mooring...

  12. A controlled intervention study concerning the effect of intended temperature rise on house dust mite load

    DEFF Research Database (Denmark)

    Sidenius, Kirsten E; Hallas, Thorkil E; Poulsen, Lars K.

    2002-01-01

    In epidemiological studies, increased indoor temperature--producing a lower relative humidity--is associated with low house dust mite (HDM) load. Twenty-eight dwellings were allocated for either intervention (12/15 completed) or control (11/13 completed). In the intervention group, participants w...

  13. Experimental study on the potential of higher octane number fuels for low load partially premixed combustion

    NARCIS (Netherlands)

    Wang, S.; van der Waart, K.; Somers, B.; de Goey, P.

    2017-01-01

    The optimal fuel for partially premixed combustion (PPC) is considered to be a gasoline boiling range fuel with an octane number around 70. Higher octane number fuels are considered problematic with low load and idle conditions. In previous studies mostly the intake air temperature did not exceed 30

  14. Divertor power load studies for attached L-mode single-null plasmas in TCV

    NARCIS (Netherlands)

    Maurizio, R.; Elmore, S.; Fedorczak, N.; Gallo, A.; Reimerdes, H.; Labit, B.; Theiler, C.; Tsui, C. K.; Vijvers, W. A. J.; TCV team,; MST1 Team,

    2018-01-01

    This paper investigates the power loads at the inner and outer divertor targets of attached, Ohmic L-mode, deuterium plasmas in the TCV tokamak, in various experimental situations using an Infrared thermography system. The study comprises variations of the outer divertor leg length and target flux

  15. Study of evacuation times based on recent accident history

    International Nuclear Information System (INIS)

    Mills, G.S.; Neuhauser, K.S.

    1995-01-01

    A key parameter in the calculation of accident dose-risks by the RADTRAN 4 code is the time assigned for evacuation of the affected area surrounding the accident. Currently, in the interest of assured conservatism, this time is set at 24 hrs. Casual anecdotal evidence has indicated that this value is overly conservative and results in assignment of overly conservative estimates of accident dose-risk. Therefore, a survey of recent truck accidents involving various hazardous materials which required evacuation of surrounding populations reported in various news media was undertaken. Accounts of pertinent scenarios were gleaned from databases citing newspapers and other periodicals, and the local authorities involved in each were contacted to get details of the evacuation including time required. This paper presents the data obtained in the study and the resultant mean evacuation time plus limits and factors influencing specific results together with conclusions regarding the appropriate value to be used in the RADTRAN 4 code

  16. Molecular Study of the Amazonian Macabea Cattle History.

    Science.gov (United States)

    Vargas, Julio; Landi, Vincenzo; Martínez, Amparo; Gómez, Mayra; Camacho, María Esperanza; Álvarez, Luz Ángela; Aguirre, Lenin; Delgado, Juan Vicente

    2016-01-01

    Macabea cattle are the only Bos taurus breed that have adapted to the wet tropical conditions of the Amazon. This breed has integrated into the culture of the indigenous Shuar-Asuar nations probably since its origins, being one of the few European zoogenetic resources assimilated by the deep-jungle Amazon communities. Despite its potential for local endogenous sustainable development, this breed is currently endangered. The present study used molecular genetics tools to investigate the within- and between-breeds diversity, in order to characterize the breed population, define its associations with other breeds, and infer its origin and evolution. The within-breed genetic diversity showed high values, as indicated by all genetic parameters, such as the mean number of alleles (MNA = 7.25±2.03), the observed heterozygosity (Ho = 0.72±0.02) and the expected heterozygosity (He = 0.72±0.02). The between-breeds diversity analysis, which included factorial correspondence analysis, Reynolds genetic distance, neighbor-joining analysis, and genetic structure analysis, showed that the Macabea breed belongs to the group of the American Creoles, with a Southern-Spain origin. Our outcomes demonstrated that the Macabea breed has a high level of purity and null influences of exotic cosmopolitan breeds with European or Asiatic origin. This breed is an important zoogenetic resource of Ecuador, with relevant and unique attributes; therefore, there is an urgent need to develop conservation strategies for the Macabea breed.

  17. The History of Cosmic Ray Studies after Hess

    Energy Technology Data Exchange (ETDEWEB)

    Grupen, Claus, E-mail: grupen@physik.uni-siegen.de

    2013-06-15

    The discovery of cosmic rays by Victor Hess was confirmed with balloon flights at higher altitudes by Kolhörster. Soon the interest turned into questions about the nature of cosmic rays: gamma rays or particles? Subsequent investigations have established cosmic rays as the birthplace of elementary particle physics. The 1936 Nobel prize was shared between Victor Hess and Carl Anderson. Anderson discovered the positron in a cloud chamber. The positron was predicted by Dirac several years earlier. Many new results came now from studies with cloud chambers and nuclear emulsions. Anderson and Neddermeyer saw the muon, which for some time was considered to be a candidate for the Yukawa particle responsible for nuclear binding. Lattes, Powell, Occhialini and Muirhead clarified the situation by the discovery of the charged pions in cosmic rays. Rochester and Butler found V's, which turned out to be short-lived neutral kaons decaying into a pair of charged pions. Λ's, Σ's and Ξ's were found in cosmic rays using nuclear emulsions. After that period, accelerators and storage rings took over. The unexpected renaissance of cosmic rays started with the search for solar neutrinos and the observation of the supernova 1987A and other accelerators in the sky. With the observation of neutrino oscillations one began to look beyond the standard model of elementary particles. After 100 years of cosmic ray research we are again at the beginning of a new era, and cosmic rays may contribute to solve the many open questions, like dark matter and dark energy, by providing energies well beyond those of earth-bound accelerators.

  18. Study on infrasonic characteristics of coal samples in failure process under uniaxial loading

    Directory of Open Access Journals (Sweden)

    Bing Jia

    Full Text Available To study the precursory failure infrasonic characteristics of coal samples, coal rock stress loading system and infrasonic wave acquisition system were adopted, and infrasonic tests in uniaxial loading process were made for the coal samples in the studied area. Wavelet filtering, fast Fourier transform, and relative infrasonic energy methods were used to analyze the characteristics of the infrasonic waves in the loading process, including time domain characteristics, and relative energy. The analysis results demonstrated that the frequencies of the infrasonic signals in the loading process mainly distribute within 5–10 Hz, which are significantly different from noise signals. The changes of the infrasonic signals show clear periodic characters in time domain. Meanwhile, the relative energy changes of the infrasonic wave also show periodic characters, which are divided into two stages by the yield limit of coal samples, and are clear and easy to be recognized, so that they can be used as the precursory characteristics for recognizing coal sample failures. Moreover, the infrasonic waves generated by coal samples have low frequency and low attenuation, which can be collected without coupling and transmitted in long distance. This study provides an important support for the further in-situ prediction of coal rock failures. Keywords: Infrasound, Relative energy, Time-frequency analysis, Failure prediction, Identification feature

  19. Can concurrent memory load reduce distraction? A replication study and beyond.

    Science.gov (United States)

    Gil-Gómez de Liaño, Beatriz; Stablum, Franca; Umiltà, Carlo

    2016-01-01

    The effects of concurrent working memory load in attentional processes have been 1 of the most puzzling issues in cognitive psychology. Studies have shown detrimental effects, no effects, and even beneficial effects of working memory load in different attentional tasks. In the present study we attempted to replicate Kim, Kim, and Chun's (2005, Experiment 3b) findings of beneficial effects of concurrent working memory load in a spatial Stroop-like task. In 3 experiments in which our sample was 3 times larger than that in the original Kim et al. study, we could not replicate their findings. The results are discussed in terms of what may have produced the conflicting results, trying to shed light on how working memory load affects attentional tasks. Also, we emphasize the importance of using adequately large samples in cognitive research. Although we acknowledge the relevance of meta-analyses to analyze conflicting results, in the present article we stress (perhaps more important) the power of an essential trademark in science for research development: replicability. (c) 2015 APA, all rights reserved).

  20. Experimental studies on the performance of novel layered materials under highly dynamic loads

    Energy Technology Data Exchange (ETDEWEB)

    Shukla, A, E-mail: shuklaa@egr.uri.ed [Dynamic Photomechanics Laboratory Department of Mechanical Engineering and Applied Mechanics University of Rhode Island, Kingston, RI 02881 (United States)

    2009-08-01

    This paper focuses on the experimental observations of the performance of different layered composite material systems subjected to blast loadings. These material systems include layered composites and sandwich composite materials. A controlled blast loading of pre-defined pressure magnitude and rise time were obtained using a shock tube apparatus. Rectangular plate elements of the desired material system were subjected to such a controlled blast loading and the effects of the blast loading on these elements were studied using optical and residual strength measurements. A high speed imaging technique was utilized to study the damage modes and mechanisms in real time. It was observed that layering of a conventional composite material with a soft visco-elastic polymer provided better blast resistance and sandwiching the polymer greatly enhanced its survivability under extreme air blast conditions. Aside from layering the conventional composite material with a soft visco-elastic polymer, it was observed that layering or grading the core can successfully mitigate the impact damage and thus improve the overall blast resistance as well. In addition to these, three dimensional (3D) woven skin and core reinforcements were introduced in the conventional sandwich composites and their effects on the blast resistance were studied experimentally. It was observed that these reinforcements also enhance the blast resistance of conventional sandwich composites by changing the mechanism of failure initiation and propagation in these sandwich structures.

  1. A Brief History of Soils and Human Health Studies

    Science.gov (United States)

    Brevik, Eric C.; Sauer, Thomas J.

    2013-04-01

    scientist to date to be awarded a Nobel Prize. In the 1940s and 50s William Albrecht of the University of Missouri became interested in links between soils and human health, an interest that lead to the publication of several papers. Albrecht's works focused on links between soil fertility and dental health, with a particular focus on the relationships between soil fertility and dental cavities. However, Albrecht did extend the relationships between soil fertility and human health out to broader, more general health issues in some of his writings as well. Well-known figures such as Sir Albert Howard and J.I. Rodale also published works in the 1940s that included soils and human health components. Then André Voisin published "Soil, Grass, and Cancer" in 1959. Much of Voisin's work focused on nutrient content in soils, including both nutrient deficiencies and imbalances, and how that influences nutrient status in plants and animals that are in turn consumed by humans. Several health problems are discussed, including but not limited to birth defects, goiter, mental illness, diabetes, and cancer. Voisin concluded that the medical profession had largely ignored soils in their efforts to improve human health, but that soil science should be the foundation of preventative medicine. Soils and human health studies continued in the later part of the 20th Century. The health effects of exposures to radioactive elements in soils received considerable attention after the 1986 Chernobyl incident, however, even prior to Chernobyl radionuclides in the soil and how they may affect human health were receiving attention. Investigations into the effects of heavy metals in soils became a common theme as did organic chemicals in soils and the effects of trace elements on human health. Following up on the discovery of antibiotics, soil organisms received increased attention as they related to human health. By the end of the 1900s, M.A. Oliver (1997) noted that "… there is a dearth of

  2. Natural history of untreatable hepatocellular carcinoma: A retrospective cohort study.

    Science.gov (United States)

    Cabibbo, Giuseppe; Maida, Marcello; Genco, Chiara; Parisi, Pietro; Peralta, Marco; Antonucci, Michela; Brancatelli, Giuseppe; Cammà, Calogero; Craxì, Antonio; Di Marco, Vito

    2012-09-27

    median survival was 6.8 mo, and the 1-year survival was 32%. The 1-year survival according to BCLC classes was 100%, 79%, 12% and 0%, for BCLC A, B, C and D, respectively. There was a significant difference in survival between each BCLC class. The median survival of patients of BCLC stages A, B, C and D was 33, 17.4, 6.9, and 1.8 mo, respectively (P < 0.05 for comparison between stages). The median survival of Child-Pugh A, B and C classes were 9.8 mo (range 6.4-13), 6.1 (range 4.9-7.3), and 3.7 (range 1.5-6), respectively (P < 0.05 for comparison between stages). By univariate analysis, the variables significantly associated to an increased liklihood of mortality were Eastern Cooperative Oncology Group performance status (PS), presence of ascites, low level of albumin, elevated level of bilirubin, international normalized ratio (INR) and Log-[(α fetoprotein (AFP)]. At multivariate analysis, mortality was independently predicted by bad PS (P < 0.0001), high INR values (P = 0.0001) and elevated Log-(AFP) levels (P = 0.009). This study confirms the heterogeneous behavior of untreated HCC. BCLC staging remains an important prognostic guide and may be important in decision-making for palliative treatment.

  3. Risk of herpes zoster and family history: A Meta-analysis of case–control studies

    Directory of Open Access Journals (Sweden)

    Yi Chun Lai

    2016-01-01

    Full Text Available Background: Herpes zoster (HZ results from the reactivation of latent varicella zoster virus (VZV residing in dorsal root and cranial nerve ganglia. Advanced age and dysfunctional cell-mediated immune responses are well-established risk factors for VZV reactivation. There have been recent interests in whether there is an increased risk of the disease associated with a positive family history. Aims and Objectives: We aimed to conduct a meta-analysis to evaluate the association between HZ infection and family history. In addition, we investigated the dose-response relationship between HZ infection and the number of relatives with a history of HZ. Materials and Methods: Observational studies were searched from MEDLINE, EMBASE, and Cochrane Central Register from inception to April 15, 2015. The Meta-analysis of Observational Studies in Epidemiology guidelines were followed in conducting this study. To estimate the pooled odds ratio, random-effects model of DerSimonian and Laird was used. Heterogeneity between studies was assessed using the I2 statistic. A dose-response meta-analysis with studies that reported appropriate data were done using the generalized least squares for trend method. Results: Five studies, yielding a total of 4169 subjects, were identified for meta-analysis. Cases with HZ were 3.03 (95% confidence interval [CI]: 1.86–4.94, P < 0.001 and 3.27 (95% CI: 1.75–6.10, P < 0.001 times more likely to report the first-degree relatives and total relatives with a history of HZ, respectively. A significant positive dose-response relationship between the risk of HZ infection and the number of relatives with a history of HZ was also demonstrated (P < 0.001. Conclusions: This meta-analysis demonstrated that family history is a significant risk factor for HZ infection. This risk has a dose-response relationship with the number of relatives with a history of HZ.

  4. Experimental Study on Fatigue Behaviour of BFRP-Concrete Bond Interfaces under Bending Load

    Directory of Open Access Journals (Sweden)

    Jianhe Xie

    2018-01-01

    Full Text Available Basalt fiber reinforced polymer (BFRP composites are increasingly being used to retrofit concrete structures by external bonding. For such strengthened members, the BFRP-concrete interface plays the crucial role of transferring stresses. This study aims to investigate the fatigue behaviour of the interface under bending load. A series of tests were conducted on BFRP-concrete bonded joint, including static, fatigue, and postfatigue loading. The fatigue failure modes, the development of deflection, the evolution of BFRP strains, and the propagation of interfacial cracks were analysed. In addition, the debonding-induced fatigue life of BFRP-concrete bonded joints was studied. Finally, a new model of fatigue life was proposed by defining the effective fatigue bond stress. The results showed that the fatigue experience has a significant effect on the BFRP strength especially near the root of concrete transverse crack and on the bond performance of the adhesive near the interface crack tip. There are two main fatigue failure modes: BFRP rupture and BFRP debonding. The fatigue damage development of the bond interface has three stages: rapid, stable, and unstable growth. The proposed model for the debonding-induced fatigue life is more conservative for the BFRP-concrete bonded joints under pure shear load than for those under bending load.

  5. Intraoperative Noise Increases Perceived Task Load and Fatigue in Anesthesiology Residents: A Simulation-Based Study.

    Science.gov (United States)

    McNeer, Richard R; Bennett, Christopher L; Dudaryk, Roman

    2016-02-01

    Operating rooms are identified as being one of the noisiest of clinical environments, and intraoperative noise is associated with adverse effects on staff and patient safety. Simulation-based experiments would offer controllable and safe venues for investigating this noise problem. However, realistic simulation of the clinical auditory environment is rare in current simulators. Therefore, we retrofitted our operating room simulator to be able to produce immersive auditory simulations with the use of typical sound sources encountered during surgeries. Then, we tested the hypothesis that anesthesia residents would perceive greater task load and fatigue while being given simulated lunch breaks in noisy environments rather than in quiet ones. As a secondary objective, we proposed and tested the plausibility of a novel psychometric instrument for the assessment of stress. In this simulation-based, randomized, repeated-measures, crossover study, 2 validated psychometric survey instruments, the NASA Task Load Index (NASA-TLX), composed of 6 items, and the Swedish Occupational Fatigue Inventory (SOFI), composed of 5 items, were used to assess perceived task load and fatigue, respectively, in first-year anesthesia residents. Residents completed the psychometric instruments after being given lunch breaks in quiet and noisy intraoperative environments (soundscapes). The effects of soundscape grouping on the psychometric instruments and their comprising items were analyzed with a split-plot analysis. A model for a new psychometric instrument for measuring stress that combines the NASA-TLX and SOFI instruments was proposed, and a factor analysis was performed on the collected data to determine the model's plausibility. Twenty residents participated in this study. Multivariate analysis of variance showed an effect of soundscape grouping on the combined NASA-TLX and SOFI instrument items (P = 0.003) and the comparisons of univariate item reached significance for the NASA Temporal

  6. The Development of Dalton's Atomic Theory as a Case Study in the History of Science: Reflections for Educators in Chemistry

    Science.gov (United States)

    Viana, Helio Elael Bonini; Porto, Paulo Alves

    2010-01-01

    The inclusion of the history of science in science curricula--and specially, in the curricula of science teachers--is a trend that has been followed in several countries. The reasons advanced for the study of the history of science are manifold. This paper presents a case study in the history of chemistry, on the early developments of John…

  7. Experimental study of low amplitude, long-duration mechanical loading of reactive materials

    International Nuclear Information System (INIS)

    Urtiew, P A; Forbes, J W

    2000-01-01

    Studies of the low amplitude, long-duration mechanical loading of reactive materials rely very heavily on the experimental data in general and in particular on the data obtained from gauges placed within the experimental test sample to measure accurately the local changes of parameters of the investigated material. For a complete description of these changes taking place in a dynamically loaded material one would like to know both the spatial and the temporal resolution of pressure, temperature, volume, wave and mass velocity. However, temperature and volume are not easily attainable. Therefore, most of the in-situ work is limited to measurements of pressure and both wave and mass velocities. Various types of these gauges will be discussed and their records will be illustrated. Some of these gauges have limitations but are better suited for particular applications than others. These aspects will also be discussed. Main limitation of most in-situ gauges is that they are built for one-dimensional application. However, some work is being done to develop two-dimensional gauges. This work will also be briefly discussed. While these experiments are necessary to validate theoretical models of the phenomenon, they can also provide sufficient amount of data to yield complete information on material characteristics such as its equation of state (EOS), its phase change under certain loads and its sensitivity to shock loading. Processing of these data to get important information on the behavior of both reactive and non-reactive materials will also be demonstrated

  8. Localized Fluctuant Oscillatory Activity by Working Memory Load: A Simultaneous EEG-fMRI Study

    Directory of Open Access Journals (Sweden)

    Xiaojie Zhao

    2017-10-01

    Full Text Available Working memory (WM is a resource-limited memory system for temporary storage and processing of brain information during the execution of cognitive tasks. Increased WM load will increase the amount and difficulty of memory information. Several studies have used electroencephalography (EEG or functional magnetic resonance imaging (fMRI to explore load-dependent cognition processing according to the time courses of electrophysiological activity or the spatial pattern of blood oxygen metabolic activity. However, the relationships between these two activities and the underlying neural mechanism are still unclear. In this study, using simultaneously collected EEG and fMRI data under an n-back verbal WM task, we modeled the spectral perturbation of EEG oscillation and fMRI activation through joint independent component analysis (JICA. Multi-channel oscillation features were also introduced into the JICA model for further analysis. The results showed that time-locked activity of theta and beta were modulated by memory load in the early stimuli evaluation stage, corresponding to the enhanced activation in the frontal and parietal lobe, which were involved in stimulus discrimination, information encoding and delay-period activity. In the late response selection stage, alpha and gamma activity changes dependent on the load correspond to enhanced activation in the areas of frontal, temporal and parietal lobes, which played important roles in attention, information extraction and memory retention. These findings suggest that the increases in memory load not only affect the intensity and time course of the EEG activities, but also lead to the enhanced activation of brain regions which plays different roles during different time periods of cognitive process of WM.

  9. Localized Fluctuant Oscillatory Activity by Working Memory Load: A Simultaneous EEG-fMRI Study.

    Science.gov (United States)

    Zhao, Xiaojie; Li, Xiaoyun; Yao, Li

    2017-01-01

    Working memory (WM) is a resource-limited memory system for temporary storage and processing of brain information during the execution of cognitive tasks. Increased WM load will increase the amount and difficulty of memory information. Several studies have used electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) to explore load-dependent cognition processing according to the time courses of electrophysiological activity or the spatial pattern of blood oxygen metabolic activity. However, the relationships between these two activities and the underlying neural mechanism are still unclear. In this study, using simultaneously collected EEG and fMRI data under an n-back verbal WM task, we modeled the spectral perturbation of EEG oscillation and fMRI activation through joint independent component analysis (JICA). Multi-channel oscillation features were also introduced into the JICA model for further analysis. The results showed that time-locked activity of theta and beta were modulated by memory load in the early stimuli evaluation stage, corresponding to the enhanced activation in the frontal and parietal lobe, which were involved in stimulus discrimination, information encoding and delay-period activity. In the late response selection stage, alpha and gamma activity changes dependent on the load correspond to enhanced activation in the areas of frontal, temporal and parietal lobes, which played important roles in attention, information extraction and memory retention. These findings suggest that the increases in memory load not only affect the intensity and time course of the EEG activities, but also lead to the enhanced activation of brain regions which plays different roles during different time periods of cognitive process of WM.

  10. Towards a critical dialogue between the history of sport, management history, and sport management/organisation studies in research and teaching

    OpenAIRE

    McDowell, Matthew

    2015-01-01

    This article discusses possibilities for a critical dialogue between the history of sport, management history, and sport management/organization studies. Many historians of sport will find themselves employed in sport management programmes, and these programmes allow the potential to interpret historical perspectives on sport, as well as historical research methods in sport management. This offers possibilities in terms of research as well. However, if historians are to engage in a research a...

  11. Study of Copolymer Composition on Drug Loading Efficiency of Enalapril in Polymersomes and Cytotoxicity of Drug Loaded Nanoparticles.

    Science.gov (United States)

    Danafar, H; Manjili, H K; Najafi, M

    2016-09-01

    Enalapril was used for hypertension and congestive heart failure. Di-block mPEG-PCL copolymers were synthesized and used to prepare of polymersomes for controlled release of enalapril as a hydrophilic drug. The various methods such as HNMR, FTIR, GPC, DSC, PCS and AFM performed for characterization of the polymersomes. The results of AFM showed that the polymersomes had spherical structure and the size of nanoparticles was 97 nm. Drug-loading efficiency of nanoparticles from copolymers with compositions of mPEG1-PCL1, mPEG2-PCL2, and mPEG3-PCL3 were 14.43%, 19.8%, and 12.33% respectively. The release profile of enalapril for drug loaded nanoparticles prepared from mPEG3-PCL3 was very fast and release profile for the nanoparticles prepared from mPEG1-PCL1 and mPEG2-PCL2 was sustained. The IC 50 value of enalapril was determined to be 8 μM while EPM/m-PEG-PCL nanoparticles did not show significant toxicity at equal concentrations in comparison with enalapril drug. Therapeutic preparations of mPEG-PCL micelle are calibrated by the mouse LD 50 assay. A dose-finding scheme of the polymeric micelle showed a safe dose of mPEG-PCL micelles was approximately 330 mg/kg in mice. The relationship between the numbers of animals, number of doses, duration of the assay used to estimate the LD 50 and the precision of the assay were investigated. Overall, the results was showed that m-PEG-PCL polymersomes can be considered as a promising carrier for hydrophilic drugs. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Synthesis of MgO nanoparticle loaded mesoporous Al2O3 and its defluoridation study

    International Nuclear Information System (INIS)

    Dayananda, Desagani; Sarva, Venkateswara R.; Prasad, Sivankutty V.; Arunachalam, Jayaraman; Parameswaran, Padmanabhan; Ghosh, Narendra N.

    2015-01-01

    Highlights: • Simple and cost effective preparation of MgO nanoparticles loaded mesoporous Al 2 O 3 . • Adsorbents possess high surface area and mesoporous structure. • Higher fluoride removal capacity of MgO loaded Al 2 O 3 than that of pure Al 2 O 3 . • Faster fluoride adsorption kinetics of MgO loaded Al 2 O 3 from water. - Abstract: MgO nanoparticle loaded mesoporous alumina has been synthesized using a simple aqueous solution based cost effective method for removal of fluoride from water. Wide angle powder X-ray diffraction, nitrogen adsorption desorption analysis, transmission electron microscopy techniques and energy dispersive X-ray spectroscopy were used to characterize the synthesized adsorbents. Synthesized adsorbents possess high surface area with mesoporous structure. The adsorbents have been thoroughly investigated for the adsorption of F − using batch adsorption method. MgO nanoparticle loading on mesoporous Al 2 O 3 enhances the F − adsorption capacity of Al 2 O 3 from 56% to 90% (initial F − concentration = 10 mg L −1 ). Kinetic study revealed that adsorption kinetics follows the pseudo-second order model, suggesting the chemisorption mechanism. The F − adsorption isotherm data was explained by both Langmuir and Freundlich model. The maximum adsorption capacity of 40MgO@Al 2 O 3 was 37.35 mg g −1 . It was also observed that, when the solutions having F − concentration of 5 mg L −1 and 10 mg L −1 was treated with 40MgO@Al 2 O 3 , the F − concentration in treated water became <1 mg L −1 , which is well below the recommendation of WHO

  13. The Norwegian curriculum in history and historical thinking: a case study of three lower secondary schools

    Directory of Open Access Journals (Sweden)

    Lisbeth Bergum Johanson

    2015-03-01

    Full Text Available AbstractThe didactics of history and the content of the curriculum and syllabi have changed over the years in order to make history more relevant for the students of today. It is important to provide students with “knowing what” knowledge in addition to “knowing how” knowledge in order to support and develop critical thinking and historical understanding. One way of promoting historical understanding is through introducing the concepts of historical thinking. However, studies show that history classes often promote teaching that is still quite traditional, using history books uncritically and without problematizing their truthfulness, which do not make students see how history is formed, nor how it can be important for the present and the future. The present article explores whether the concepts of historical thinking are encouraged and used in three different lower secondary schools in Norway today. The main sources of data are current history textbooks, teaching plans, tests and assignments. The findings of the study show that the concepts of historical thinking are not made clear and explicit enough in neither history books, plans nor tests. Furthermore, it seems like reproduction rather than reflection is focused on in many classrooms, making it difficult to develop a historical understanding. It is therefore suggested that both teachers and students learn and work thoroughly with the concepts of historical thinking.schools in Norway today. History books in use, plans, tests and assignments were considered important empirical information for the research question. The findings of the study show that the concepts of historical thinking are not clear enough neither in history books, plans nor tests. Furthermore, it seems like reproduction rather than reflections are practiced in many classrooms, making it difficult to get a historical understanding. To accomplish historical understanding it is suggested that both teachers and students

  14. An Old Fad of Great Promise: Reverse Chronology History Teaching in Social Studies Classes

    Science.gov (United States)

    Misco, Thomas; Patterson, Nancy C.

    2009-01-01

    This article revisits and explores the promises and challenges of reverse chronology history instruction within the social studies. In response to student disinterest in social studies, changes in our educational culture that often value content knowledge exclusively, and marginalization of instructional time stemming from testing burdens, reverse…

  15. State-dependent life-history strategies : A long-term study on oystercatchers

    NARCIS (Netherlands)

    van de Pol, Martijn

    2006-01-01

    The research described in this thesis is part of a long-term field study on free-living Oystercatchers (Haematopus ostralegus), on the Dutch Wadden Sea island of Schiermonnikoog.The study was started in 1983 by Jan Hulscher, and since then a lineage of PhDstudents has investigated life-history

  16. A User Study of Visualization Effectiveness Using EEG and Cognitive Load

    KAUST Repository

    Anderson, E. W.; Potter, K. C.; Matzen, L. E.; Shepherd, J. F.; Preston, G. A.; Silva, C. T.

    2011-01-01

    Effectively evaluating visualization techniques is a difficult task often assessed through feedback from user studies and expert evaluations. This work presents an alternative approach to visualization evaluation in which brain activity is passively recorded using electroencephalography (EEG). These measurements are used to compare different visualization techniques in terms of the burden they place on a viewer's cognitive resources. In this paper, EEG signals and response times are recorded while users interpret different representations of data distributions. This information is processed to provide insight into the cognitive load imposed on the viewer. This paper describes the design of the user study performed, the extraction of cognitive load measures from EEG data, and how those measures are used to quantitatively evaluate the effectiveness of visualizations. © 2011 The Author(s).

  17. Study on the Vehicle Dynamic Load Considering the Vehicle-Pavement Coupled Effect

    Science.gov (United States)

    Xu, H. L.; He, L.; An, D.

    2017-11-01

    The vibration of vehicle-pavement interaction system is sophisticated random vibration process and the vehicle-pavement coupled effect was not considered in the previous study. A new linear elastic model of the vehicle-pavement coupled system was established in the paper. The new model was verified with field measurement which could reflect the real vibration between vehicle and pavement. Using the new model, the study on the vehicle dynamic load considering the vehicle-pavement coupled effect showed that random forces (centralization) between vehicle and pavement were influenced largely by vehicle-pavement coupled effect. Numerical calculation indicated that the maximum of random forces in coupled model was 2.4 times than that in uncoupled model. Inquiring the reason, it was found that the main vibration frequency of the vehicle non-suspension system was similar with that of the vehicle suspension system in the coupled model and the resonance vibration lead to vehicle dynamic load increase significantly.

  18. A User Study of Visualization Effectiveness Using EEG and Cognitive Load

    KAUST Repository

    Anderson, E. W.

    2011-06-01

    Effectively evaluating visualization techniques is a difficult task often assessed through feedback from user studies and expert evaluations. This work presents an alternative approach to visualization evaluation in which brain activity is passively recorded using electroencephalography (EEG). These measurements are used to compare different visualization techniques in terms of the burden they place on a viewer\\'s cognitive resources. In this paper, EEG signals and response times are recorded while users interpret different representations of data distributions. This information is processed to provide insight into the cognitive load imposed on the viewer. This paper describes the design of the user study performed, the extraction of cognitive load measures from EEG data, and how those measures are used to quantitatively evaluate the effectiveness of visualizations. © 2011 The Author(s).

  19. Reactivity and reaction rate studies on the fourth loading of ZENITH

    International Nuclear Information System (INIS)

    Cameron, I.R.; Freemantle, R.G.; Reed, D.L.; Wilson, D.J.

    1963-08-01

    The determination of the excess reactivity, control rod worths, prompt neutron lifetime, flux fine structure, and reaction rates of various nuclides for the fourth loading of the heated zero energy reactor ZENITH is described. The core contains 7.76 kg of U235, giving a carbon/U235 atom ratio of 7578, and forms the most dilute of the range studied. Comparisons of the experimental results with calculations using multigroup diffusion codes are presented. (author)

  20. Reactivity and reaction rate studies on the fourth loading of ZENITH

    Energy Technology Data Exchange (ETDEWEB)

    Cameron, I R; Freemantle, R G; Reed, D L; Wilson, D J [General Reactor Physics Division, Atomic Energy Establishment, Winfrith, Dorchester, Dorset (United Kingdom)

    1963-08-15

    The determination of the excess reactivity, control rod worths, prompt neutron lifetime, flux fine structure, and reaction rates of various nuclides for the fourth loading of the heated zero energy reactor ZENITH is described. The core contains 7.76 kg of U235, giving a carbon/U235 atom ratio of 7578, and forms the most dilute of the range studied. Comparisons of the experimental results with calculations using multigroup diffusion codes are presented. (author)

  1. Preparation, characterization, drug release and computational modelling studies of antibiotics loaded amorphous chitin nanoparticles.

    Science.gov (United States)

    Gayathri, N K; Aparna, V; Maya, S; Biswas, Raja; Jayakumar, R; Mohan, C Gopi

    2017-12-01

    We present a computational investigation of binding affinity of different types of drugs with chitin nanocarriers. Understanding the chitn polymer-drug interaction is important to design and optimize the chitin based drug delivery systems. The binding affinity of three different types of anti-bacterial drugs Ethionamide (ETA) Methacycline (MET) and Rifampicin (RIF) with amorphous chitin nanoparticles (AC-NPs) were studied by integrating computational and experimental techniques. The binding energies (BE) of hydrophobic ETA, hydrophilic MET and hydrophobic RIF were -7.3kcal/mol, -5.1kcal/mol and -8.1kcal/mol respectively, with respect to AC-NPs, using molecular docking studies. This theoretical result was in good correlation with the experimental studies of AC-drug loading and drug entrapment efficiencies of MET (3.5±0.1 and 25± 2%), ETA (5.6±0.02 and 45±4%) and RIF (8.9±0.20 and 53±5%) drugs respectively. Stability studies of the drug encapsulated nanoparticles showed stable values of size, zeta and polydispersity index at 6°C temperature. The correlation between computational BE and experimental drug entrapment efficiencies of RIF, ETA and MET drugs with four AC-NPs strands were 0.999 respectively, while that of the drug loading efficiencies were 0.854 respectively. Further, the molecular docking results predict the atomic level details derived from the electrostatic, hydrogen bonding and hydrophobic interactions of the drug and nanoparticle for its encapsulation and loading in the chitin-based host-guest nanosystems. The present results thus revealed the drug loading and drug delivery insights and has the potential of reducing the time and cost of processing new antibiotic drug delivery nanosystem optimization, development and discovery. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits

    OpenAIRE

    Sun, Hongfan

    2009-01-01

    Linhua Zhang1, Yue Li2, Chao Zhang1, Yusheng Wang2, Cunxian Song11Institute of Biomedical Engineering, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China; 2Department of Ophthalmology, Institute of Ophthalmology of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaAbstract: The aim of the study was to investigate the tolerance and pharmacokinetics of dexamethasone (DEX)-loaded poly(lactic acid–co-glycolic acid) ...

  3. The Feasibility Study on Thermal Loading Control of Wind Power Converters with a Flexible Switching Frequency

    DEFF Research Database (Denmark)

    Qin, Zian; Wang, Huai; Blaabjerg, Frede

    2015-01-01

    Thermal loading of wind power converters is critical to their reliability performance. Especially for IGBT modules applied in a converter, both of the mean value and variation of the junction temperature have significant impact on the lifetime. Besides other strategies to reduce the thermal loadi...... the temperature fluctuations due to wind speed variations. The trade-off between the reduced amplitude of temperature fluctuations and the additional power losses that may be introduced is quantitatively studied....

  4. Loading pattern calculated by inverse optimization vs traditional dosimetry systems of intracavitary brachytherapy of cervical cancer: a dosimetric study

    International Nuclear Information System (INIS)

    Jamema, S.V.; Deshpande, D.D.; Kirisits, C.; Trnkova, P.; Poetter, R.; Mahantshetty, U.; Shrivastava, S.K.; Dinshaw, K.A.

    2008-01-01

    In the recent past, inverse planning algorithms were introduced for intracavitary brachytherapy planning (ICBT) for cervical cancer. The loading pattern of these algorithms in comparison with traditional systems may not be similar. The purpose of this study was to objectively compare the loading patterns of traditional systems with the inverse optimization. Based on the outcome of the comparison, an attempt was made to obtain a loading pattern that takes into account the experience made with the inverse optimization

  5. Yang Shengmao and the Development of World History Studies in China

    Institute of Scientific and Technical Information of China (English)

    Li Jianming[1

    2015-01-01

    After the adjustment of disciplinary categorization of Chinese colleges in 2011, world history, along with Chinese history and archeology, became the first-level disciplines in history. As a first-level discipline, world history has a meaning clearly different from its western sense: it is not a simply course, nor a single field, but a disciplinary system combined by many second-level disciplines, including ancient world history, modern world history, history of specific nations or regions, and history of specialized subjects.

  6. Preformulation Studies of Bee Venom for the Preparation of Bee Venom-Loaded PLGA Particles

    Directory of Open Access Journals (Sweden)

    Min-Ho Park

    2015-08-01

    Full Text Available It is known that allergic people was potentially vulnerable to bee venom (BV, which can induce an anaphylactic shock, eventually leading to death. Up until recently, this kind of allergy was treated only by venom immunotherapy (VIT and its efficacy has been recognized worldwide. This treatment is practiced by subcutaneous injections that gradually increase the doses of the allergen. This is inconvenient for patients due to frequent injections. Poly (D,L-lactide-co-glycolide (PLGA has been broadly studied as a carrier for drug delivery systems (DDS of proteins and peptides. PLGA particles usually induce a sustained release. In this study, the physicochemical properties of BV were examined prior to the preparation of BV-loaded PLGA nanoparticles NPs. The content of melittin, the main component of BV, was 53.3%. When protected from the light BV was stable at 4 °C in distilled water, during 8 weeks. BV-loaded PLGA particles were prepared using dichloromethane as the most suitable organic solvent and two min of ultrasonic emulsification time. This study has characterized the physicochemical properties of BV for the preparation BV-loaded PLGA NPs in order to design and optimize a suitable sustained release system in the future.

  7. Preformulation Studies of Bee Venom for the Preparation of Bee Venom-Loaded PLGA Particles.

    Science.gov (United States)

    Park, Min-Ho; Kim, Ju-Heon; Jeon, Jong-Woon; Park, Jin-Kyu; Lee, Bong-Joo; Suh, Guk-Hyun; Cho, Cheong-Weon

    2015-08-18

    It is known that allergic people was potentially vulnerable to bee venom (BV), which can induce an anaphylactic shock, eventually leading to death. Up until recently, this kind of allergy was treated only by venom immunotherapy (VIT) and its efficacy has been recognized worldwide. This treatment is practiced by subcutaneous injections that gradually increase the doses of the allergen. This is inconvenient for patients due to frequent injections. Poly (D,L-lactide-co-glycolide) (PLGA) has been broadly studied as a carrier for drug delivery systems (DDS) of proteins and peptides. PLGA particles usually induce a sustained release. In this study, the physicochemical properties of BV were examined prior to the preparation of BV-loaded PLGA nanoparticles NPs). The content of melittin, the main component of BV, was 53.3%. When protected from the light BV was stable at 4 °C in distilled water, during 8 weeks. BV-loaded PLGA particles were prepared using dichloromethane as the most suitable organic solvent and two min of ultrasonic emulsification time. This study has characterized the physicochemical properties of BV for the preparation BV-loaded PLGA NPs in order to design and optimize a suitable sustained release system in the future.

  8. The reactions of loaded carbon nanotubes, studied by novel electron microscope techniques

    International Nuclear Information System (INIS)

    Rawcliffe, A.

    1999-01-01

    A novel electron microscope technique, controlled environment transmission electron microscopy (CETEM), has been used to investigate the reaction of materials loaded within the internal cavities of carbon nanotubes. CETEM allows the introduction of up to 20 mbar of gas around an electron microscope sample, while maintaining a high resolution imaging capability. The microscope is stable, flexible and reliable under these conditions and high resolution images of encapsulated transmission metal oxide reduction have been recorded at 460 deg. C. Recently discovered carbon nanotubes have in theory many applications, many of which will require controlled reliable loading of the internal cavity. However, at present, there is little experimental evidence to confirm theoretical descriptions of the fundamental mechanisms which govern both the extent of loading and the state in which it is found. Similarly, reaction within the cavity and the effect of encapsulation on the nano-scale particle distribution must also be understood, and CETEM proves to be an ideal technique for the study of these processes. Nanotubes have been loaded from aqueous solution with (NH 4 ) 2 IrCI 6 and with molten MoO 3 or K 2 WO 4 /WO 3 . Bulk samples of the first salt are known to decompose spontaneously in air at 200 deg. C, and the bulk oxides are partially reduced at temperature under hydrogen to give potentially useful conducting phases. Comparing the reaction of these materials it is thus possible to: investigate the effect of loading on their reaction; compare the reaction of these materials in- and out-side the tube cavity; and assess the result of violent loading processes on the tubes themselves. Fortuitously, a spontaneous decomposition, a solid-gas reduction and a phase rearrangement were all recorded, allowing mechanistic implications of encapsulation to be considered for each of these reactions. Perhaps surprisingly, the results can be largely interpreted using the reported bulk

  9. Cognitive load, emotion, and performance in high-fidelity simulation among beginning nursing students: a pilot study.

    Science.gov (United States)

    Schlairet, Maura C; Schlairet, Timothy James; Sauls, Denise H; Bellflowers, Lois

    2015-03-01

    Establishing the impact of the high-fidelity simulation environment on student performance, as well as identifying factors that could predict learning, would refine simulation outcome expectations among educators. The purpose of this quasi-experimental pilot study was to explore the impact of simulation on emotion and cognitive load among beginning nursing students. Forty baccalaureate nursing students participated in teaching simulations, rated their emotional state and cognitive load, and completed evaluation simulations. Two principal components of emotion were identified representing the pleasant activation and pleasant deactivation components of affect. Mean rating of cognitive load following simulation was high. Linear regression identiffed slight but statistically nonsignificant positive associations between principal components of emotion and cognitive load. Logistic regression identified a negative but statistically nonsignificant effect of cognitive load on assessment performance. Among lower ability students, a more pronounced effect of cognitive load on assessment performance was observed; this also was statistically non-significant. Copyright 2015, SLACK Incorporated.

  10. Solid lipid nanoparticles by coacervation loaded with a methotrexate prodrug: preliminary study for glioma treatment.

    Science.gov (United States)

    Battaglia, Luigi; Muntoni, Elisabetta; Chirio, Daniela; Peira, Elena; Annovazzi, Laura; Schiffer, Davide; Mellai, Marta; Riganti, Chiara; Salaroglio, Iris Chiara; Lanotte, Michele; Panciani, Pierpaolo; Capucchio, Maria Teresa; Valazza, Alberto; Biasibetti, Elena; Gallarate, Marina

    2017-03-01

    Methotrexate-loaded biocompatible nanoparticles were tested for preliminary efficacy in glioma treatment. Behenic acid nanoparticles, prepared by the coacervation method, were loaded with the ester prodrug didodecylmethotrexate, which was previously tested in vitro against glioblastoma human primary cultures. Nanoparticle conjugation with an ApoE mimicking chimera peptide was performed to obtain active targeting to the brain. Biodistribution studies in healthy rats assessed the superiority of ApoE-conjugated formulation, which was tested on an F98/Fischer glioma model. Differences were observed in tumor growth rate (measured by MRI) between control and treated rats. In vitro tests on F98 cultured cells assessed their susceptibility to treatment, with consequent apoptosis, and allowed us to explain the apoptosis observed in glioma models.

  11. Sewage-treatment under substantial load variations in winter tourism areas--a full case study.

    Science.gov (United States)

    Winkler, S; Matsché, N; Gamperer, T; Dum, M

    2004-01-01

    The sewage-load variations in winter tourism areas are characterized by sudden increases--in the range of a factor two to three--within only a few days at the start and the end of the tourist season, especially at Christmas. The sudden load increases occur during periods of low wastewater temperatures, which is an additional demanding factor with respect to nitrogen removal. A full case study was carried out at WWTP Saalfelden, which is located near one of Austria's largest skiing resorts. The plant is designed for 80,000 PE and built according to the HYBRID-concept, which is a special two stage activated sludge process for extensive nutrient removal.

  12. Objectively measured work load, health status and sickness absence among Danish ambulance personnel. A longitudinal study

    DEFF Research Database (Denmark)

    Hansen, Claus D.

    2013-01-01

    Background: Reviews show that ambulance personnel (AP) have an increased risk of work-related health problems especially musculoskeletal disorders. Because of the unpredictable character of the AP’s work environment, standard measures of work environment exposures are imprecise. The aim...... of this presentation is to examine the associations between objectively measured work load taken from the company register, health and long-term sickness absence (LTSA) in 1-year follow up period. Methods: Data is taken from the first round of MARS – Men, accidents, risk and safety, a two wave panel study of AP...... workers in Denmark (n = 1606) collected in winter 2010/11. The response rate to the questionnaire was 62% in the baseline. The respondents were asked about health status, physical (DMQ) and psychosocial work environment factors (COPSOQ). Information from the company register about work load (e.g. mean...

  13. EEC-sponsored theoretical studies of gas cloud explosion pressure loadings

    International Nuclear Information System (INIS)

    Briscoe, F.; Curtress, N.; Farmer, C.L.; Fogg, G.J.; Vaughan, G.J.

    1979-01-01

    Estimates of the pressure loadings produced by unconfined gas cloud explosions on the surface of structures are required to assist the design of strong secondary containments in countries where the protection of nuclear installations against these events is considered to be necessary. At the present time, one difficulty in the specification of occurate pressure loadings arises from our lack of knowledge concerning the interaction between the incident pressure waves produced by unconfined gas cloud explosions and large structures. Preliminary theoretical studies include (i) general theoretical considerations, especially with regard to scaling (ii) investigations of the deflagration wave interaction with a wall based on an analytic solution for situations with planar symmetry and the application of an SRD gas cloud explosion code (GASEX 1) for situations with planar and spherical symmetry, and (iii) investigations of the interaction between shock waves and structures for situations with two-dimensional symmetry based on the application of another SRD gas cloud explosion code (GASEX 2)

  14. Experimental study on Kd of 137Cs at varying suspended load conditions

    International Nuclear Information System (INIS)

    Jaison, T.J.; Jain, Abhishek; Patra, A.K.; Ravi, P.M.; Tripathi, R.M.

    2018-01-01

    137 Cs is one of the radionuclide likely to be released through liquid effluents from a nuclear facility. It is soluble in water, but its mobility in aquatic environments is highly retarded by its strong interaction with suspended sediment. The 137 Cs + sorption by suspended load, especially in the subtropics and tropics are not fully understood. Besides, according to IAEA document in emergency situation 137 Cs and 131 I being marker radionuclides, are easier to identify and representative of all the other radionuclides present. Hence a laboratory study is carried out on sorption of 137 Cs with varying silt load, using the upstream lake water and sediments to estimate site specific distribution coefficient (K d )

  15. The use of GPS horizontals for loading studies, with applications to northern California and southeast Greenland

    DEFF Research Database (Denmark)

    Wahr, John; Khan, Shfaqat Abbas; van Dam, Tonie

    2013-01-01

    of the horizontal motion, can help determine whether nearby loading is concentrated in a small region (for example, in a single lake or glacier), and where that region is. We illustrate this method by applying it to two specific cases: an analysis of GPS data from northern California to monitor the level of Lake......We describe how GPS measurements of horizontal crustal motion can be used to augment vertical crustal motion measurements, to improve and extend GPS studies of surface loading. We show that the ratio of the vertical displacement to the horizontal displacement, combined with the direction...... Shasta, and the analysis of data from a single GPS site in southeast Greenland to determine mass variability of two large, nearby outlet glaciers: Helheim Glacier and Midgaard Glacier. The California example serves largely as a proof-of-concept, where the results can be assessed by comparing...

  16. Study of heat and hydraulic diffusions in clays under thermal loading

    International Nuclear Information System (INIS)

    Djeran, I.

    1993-01-01

    This study is a cost-sharing research programme on radioactive waste disposal and radioactive waste management. The thermal conductivity of clays is the fundamental parameter which governs the thermal diffusion and the pore pressure of the rock mass under thermal loading. Experiments have been undertaken in a reduced model, respecting representative boundary conditions. They show that the thermal conductivity depends on temperature in an unfavourable sense to the decrease of heat. On the other hand, the outflow of pore water, from the source to the exterior, has a low amplitude. A single model of porous medium allows the observations and illustrates the effects of the variation of conductivity on the behaviour of rock mass. Finally, thanks to the numerical formulations specially developed, we examine the incident of the particularities of proposed models on the thermohydromechanical behaviour of geometrically simple structures subjected to a given thermal loading

  17. Experimental study on performance of laterally loaded plumb and battered piles in layered sand

    Directory of Open Access Journals (Sweden)

    Bushra S. Albusoda

    2017-09-01

    Full Text Available This study introduces a series of single and pile group model tests subjected to lateral loads in . multilayered sand from Karbala, Iraq. The aim of this study is to investigate: the performance of the pile groups subjected to lateral loads; in which the pile batter inclination angle is changed; the effect of pile spacing (s/d ratio, the influence of using different number of piles and pile group configuration. Results revealed that the performance of single negative (Reverse Battered piles with inclination of 10° and 20° show a gain of 32% and 76 % in the ultimate lateral capacity over the regular ones. For pile groups, the use of a combination of regular, negative and positive battered piles in different angles of inclination within the same group shows a significant increase in the ultimate lateral load carrying capacity. Increasing the spacing between piles in groups of the same category shows an increase in the group efficiency, also changing the piles number within the group by using different patterns will influence the ultimate lateral resistance of the pile group.

  18. Tool-life prediction under multi-cycle loading during metal forming: a feasibility study

    Directory of Open Access Journals (Sweden)

    Hu Yiran

    2015-01-01

    Full Text Available In the present research, the friction and wear behaviour of a hard coating were studied by using ball-on-disc tests to simulate the wear process of the coated tools for sheet metal forming process. The evolution of the friction coefficient followed a typical dual-plateau pattern, i.e. at the initial stage of sliding, the friction coefficient was relatively low, followed by a sharp increase due to the breakdown of the coatings after a certain number of cyclic dynamic loadings. This phenomenon was caused by the interactive response between the friction and wear from a coating tribo-system, which is often neglected by metal forming researchers, and constant friction coefficient values are normally used in the finite element (FE simulations to represent the complex tribological nature at the contact interfaces. Meanwhile, most of the current FE simulations consider single-cycle loading processes, whereas many metal-forming operations are conducted in a form of multi-cycle loading. Therefore, a novel friction/wear interactive friction model was developed to, simultaneously, characterise the evolutions of friction coefficient and the remaining thickness of the coating layer, to enable the wear life of coated tooling to be predicted. The friction model was then implemented into the FE simulation of a sheet metal forming process for feasibility study.

  19. Study on Mechanical Characteristics of Fully Grouted Rock Bolts for Underground Caverns under Seismic Loads

    Directory of Open Access Journals (Sweden)

    Guoqing Liu

    2017-01-01

    Full Text Available This study establishes an analytical model for the interaction between the bolt and surrounding rock based on the bearing mechanism of fully grouted rock bolts. The corresponding controlled differential equation for load transfer is deduced. The stress distributions of the anchorage body are obtained by solving the equations. A dynamic algorithm for the bolt considering shear damage on the anchoring interface is proposed based on the dynamic finite element method. The rationality of the algorithm is verified by a pull-out test and excavation simulation of a rounded tunnel. Then, a case study on the mechanical characteristics of the bolts in underground caverns under seismic loads is conducted. The results indicate that the seismic load may lead to stress originating from the bolts and damage on the anchoring interface. The key positions of the antiseismic support can be determined using the numerical simulation. The calculated results can serve as a reference for the antiseismic optimal design of bolts in underground caverns.

  20. Natural history of breast cancers detected in the Swedish mammography screening programme: a cohort study

    DEFF Research Database (Denmark)

    Zahl, Per-Henrik; Gøtzsche, Peter C; Mæhlen, Jan

    2011-01-01

    The natural history of screen-detected breast cancers is not well understood. A previous analysis of the incidence change during the introduction of the Norwegian screening programme in the late 1990s suggested that the natural history of many screen-detected invasive breast cancers is to regress...... spontaneously but the study was possibly confounded by use of hormone replacement therapy in the population. We did a similar analysis of data collected during an earlier period when few women were exposed to hormone replacement therapy....

  1. Mining and territory: theoretical approaches to the field of environmental history through a case study

    Directory of Open Access Journals (Sweden)

    Francesco Panico

    2018-09-01

    Full Text Available This article aims to outline an epistemological framework for placing the field of environmental history in the context of the current endeavor of social sciences and humanities. The methodology used is defined here as “metabolic landmarks” because it is inspired by the approach of social metabolism. The results suggest that, in the study of environmental history, the specific historiographical object plays an essential role in defining the epistemic context of that hybrid field of historiography and, more generally, of social and environmental analyses.

  2. A study of smart card for radiation exposure history of patient.

    Science.gov (United States)

    Rehani, Madan M; Kushi, Joseph F

    2013-04-01

    The purpose of this article is to undertake a study on developing a prototype of a smart card that, when swiped in a system with access to the radiation exposure monitoring server, will locate the patient's radiation exposure history from that institution or set of associated institutions to which it has database access. Like the ATM or credit card, the card acts as a secure unique "token" rather than having cash, credit, or dose data on the card. The system provides the requested radiation history report, which then can be printed or sent by e-mail to the patient. The prototype system is capable of extending outreach to wherever the radiation exposure monitoring server extends, at county, state, or national levels. It is anticipated that the prototype shall pave the way for quick availability of patient exposure history for use in clinical practice for strengthening radiation protection of patients.

  3. Traffic volume and load data measurement using a portable weigh in motion system: A case study

    Directory of Open Access Journals (Sweden)

    Abu N.M. Faruk

    2016-05-01

    Full Text Available Traditionally, traffic loading characteristics are collected for pavement design and performance prediction purposes using permanent roadside weigh-in-motion (WIM stations. However, high installation and maintenance costs associated with these permanent WIM stations dictate that their deployment be mostly limited to major highways, such as the interstate network. Quite often however, pavement damage on high volume rural highways with heavy truck proportions is more severe than anticipated, and there is no effective way of quantifying the traffic loading on these highways. Therefore, this study was conducted to evaluate the potential application of portable WIM systems as a means for bringing the WIM technology to these high volume rural highways. A portable WIM unit was deployed in the Texas overweight corridor in Hidalgo County (Pharr District near the USA-Mexico border on highway FM 1016 for collecting traffic data for a minimum of three weeks in each direction. The collected traffic data were analyzed to generate traffic parameters such as volume, load spectra, and overloading information both in terms of the gross vehicle weight (GVW and axle weight. The computed traffic parameters were successful in partially explaining some of the existing pavement conditions on this highway. Overall, the study findings indicated that the portable WIM unit can be used as a convenient and cost-effective means for collecting reliable traffic information for design, analysis, and monitoring purposes. However, proper in-situ calibration of the portable WIM unit at each site is imperative prior to any real-time traffic data collection. Keywords: Traffic data, Load spectra, Truck overweight, Weigh-in-motion (WIM, Portable WIM, Texas overweight corridor

  4. History Places: A Case Study for Relational Database and Information Retrieval System Design

    Science.gov (United States)

    Hendry, David G.

    2007-01-01

    This article presents a project-based case study that was developed for students with diverse backgrounds and varied inclinations for engaging technical topics. The project, called History Places, requires that student teams develop a vision for a kind of digital library, propose a conceptual model, and use the model to derive a logical model and…

  5. Report of the Study Group on the History of Fish and Fisheries (SGHIST)

    DEFF Research Database (Denmark)

    The Study Group on the History of Fish and Fisheries (SGHIST) brings together fish-eries scientists, historians and marine biologists working on multidecadal to centen-nial changes in the marine environment, and aims at improving the understanding of the long term dynamics of fish populations...

  6. Citation Behavior of Undergraduate Students: A Study of History, Political Science, and Sociology Papers

    Science.gov (United States)

    Hendley, Michelle

    2012-01-01

    The goal of this analysis was to obtain local citation behavior data on undergraduates researching history, political science, and sociology papers. The study found that students cited books and journals even with the availability of web sources; however, usage varied by subject. References to specific websites' domains also varied across subject…

  7. Curriculum Studies in Brazil: Intellectual Histories, Present Circumstances. International and Development Education

    Science.gov (United States)

    Pinar, William F., Ed.

    2011-01-01

    This collection, comprised of chapters focused on the intellectual histories and present circumstances of curriculum studies in Brazil, is Pinar's summary of exchanges (occurring over a two-year period) between the authors and members of an International Panel (scholars working in Finland, South Africa, the United States). From these and the…

  8. The Impact of the Universal Declaration of Human Rights on the Study of History

    NARCIS (Netherlands)

    De Baets, Antoon

    There is perhaps no text with a broader impact on our lives than the 1948 Universal Declaration of Human Rights (UDHR). It is strange, therefore, that historians have paid so little attention to the UDHR. I argue that its potential impact on the study of history is profound. After asking whether the

  9. Natural History of Thyroid Function in Adults with Down Syndrome--10-Year Follow-Up Study

    Science.gov (United States)

    Prasher, V.; Gomez, G.

    2007-01-01

    Background: The natural history of thyroid function in adults with Down syndrome (DS) is unknown. Method: This study investigated annual thyroid function tests in 200 adults with DS over a 10-year period. Results: Transient and persistent thyroid dysfunction was common. The 5- and 10-year incidence of definite hypothyroidism was 0.9%-1.64% and…

  10. Teaching History with Comic Books: A Case Study of Violence, War, and the Graphic Novel

    Science.gov (United States)

    Decker, Alicia C.; Castro, Mauricio

    2012-01-01

    In this essay, the authors present a case study that demonstrates how graphic novels can be utilized in the history classroom. More specifically, they discuss the benefits (and challenges) of using comic books to teach undergraduates about war and violence. While much of their discussion focuses on the historical particularities of Uganda, their…

  11. Long-term studies of the natural history of asthma in childhood

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Bønnelykke, Klaus

    2010-01-01

    secondary prevention through the use of inhaled corticosteroids can effectively halt the long-term disease progression in childhood. In conclusion, the natural history of asthma and the associated airway changes is still poorly understood, and we have not managed to translate findings from long-term studies...

  12. Eritreo-Ethiopian studies in society and history : 1960-1995 : a supplementary bibliography

    NARCIS (Netherlands)

    Abbink, G.J.

    1996-01-01

    This bibliography on Ethiopia and Eritrea is a sequel to 'Ethiopian society and history: a bibliography of Ethiopian studies 1957-1990' (1990). The present volume, which covers the period 1990-1995, contains c. 2000 items. Books, journal articles, and articles from collective volumes have been

  13. Comparative study of hostility in depressive patients with and without a suicide attempt history.

    Science.gov (United States)

    Christodoulou, Christos; Efstathiou, Vasiliki; Ferentinos, Panagiotis; Poulios, Antonios; Papadopoulou, Athanasia; Douzenis, Athanassios

    2017-08-01

    Hostility in association with depression seems to be connected to suicidal behavior. This study aimed to evaluate hostility and its dimensions in relation to depression in patients who suffered from diagnosed depression with and without a suicide attempt history. The study included 168 participants; 58 patients with depression and suicide attempt history, 55 patients with depression without a suicide attempt history and 55 healthy controls. Hostility was assessed with the Hostility and Direction of Hostility Questionnaire, while depression with the Beck Depression Inventory (BDI). Patients with depression and a suicide attempt history compared with the patients without attempt history presented statistically significantly higher total hostility (28.71 ± 6.43 vs 24.20 ± 7.66), extroverted hostility (17.16 ± 4.37 vs 14.15 ± 4.63), acting out hostility (6.03 ± 2.09 vs 4.73 ± 1.93), and self criticism (6.95 ± 2.12 vs 5.89 ± 2.32). No statistically significant differences were found between the two clinical groups in depression according to the BDI. Moreover depressive patients with suicide attempt history scored higher in all the hostility dimensions than the controls. Therefore, it could be suggested that hostility and especially its extrapunitive dimensions are associated with suicidal behavior, since no differences in depression were recorded between the two clinical groups.

  14. Trajectories of health-related quality of life during the natural history of dementia: a six-wave longitudinal study.

    Science.gov (United States)

    Yu, Hongmei; Gao, Caihong; Zhang, Yanbo; He, Runlian; Zhou, Liye; Liang, Ruifeng

    2017-09-01

    The objective of this study was to explore profiles of quality of life (QoL) trajectories during the natural history of dementia and individual variations contributing to QoL trajectories. We conducted a longitudinal community-based study of 520 elderly people with mild cognitive impairment and 100 healthy people aged 60 years or over. We conducted six waves of assessment between October 2010 and May 2013 in Taiyuan, mainland China. Cognitively normal, mild cognitive impairment, global impairment, and Alzheimer's disease (AD) were defined as state 1, 2, 3, and 4, respectively. We assessed health-related QoL (HRQoL) via the Quality of Life-Alzheimer's Disease (QoL-AD) Chinese version. We used the latent growth curve model (LGCM) to investigate change in HRQoL over time. Latent growth curve model analysis revealed a mean initial QoL level of 29.865 with substantial variation and a significant mean slope for the whole sample. Multigroup LGCM showed substantial variations across individuals in initial QoL levels for each cognitive state transition group. For the slope factor, we found significant changes and variations for the transition from state 2 to 3 and from state 3 to 4. We estimated mean QoL levels over six assessments based on intercept, slope, and factor loadings for the whole sample and the three cognitive state transition groups. A decline in subjective QoL is not inevitable during the natural history of dementia in community settings, and there is a degree of individual variation in QoL. Future studies should investigate the factors associated with individual variations in QoL trajectories in AD. Copyright © 2016 John Wiley & Sons, Ltd.

  15. An experimental study on mass loading of soil particles on plant surfaces

    International Nuclear Information System (INIS)

    Li, J. G.; Gerzabek, M. H.; Mueck, K.

    1994-01-01

    Radionuclide contaminated soil adhered to plant surfaces can contribute to human ingestion dose. To determine this contribution, a method of 46 Sc neutron activation analysis was established and tested, by which a detection limit of 0.05 mg soil per g dry plant biomass can be obtained. In the field and greenhouse experiment the mass loading of soil on ryegrass (Lolium perenne L.) and broadbean (Vicia faba L.) was investigated and the contribution from rainsplash and wind erosion were evaluated separately. Soil retained on plant surfaces in field conditions in Seibersdorf/Austria was 5.77 ± 1.44 mg soil per g dry plant for ryegrass and 9.51 ± 0.73 mg soil per g dry plant for broadbean. Estimates of contribution from rainsplash and wind erosion to soil contamination of plants during the experimental period are 68 % and 32 % for broadbean 47 % and 53 % for ryegrass respectively. Mass loading results from field studies indicate that soil adhesion on plant surfaces can contribute up to 23 % of plant 137 Cs contamination, the transfer factors modified by mass loading decline differently, depending on 137 Cs concentration of the soil and the soil mass adhered to plant surfaces. (author)

  16. An experimental study on mass loading of soil particles on plant surfaces

    International Nuclear Information System (INIS)

    Li, J.; Gerzabek, M.H.; Mueck, K.

    1994-03-01

    Radionuclide contaminated soil adhered to plant surfaces can contribute to human ingestion dose. To determine this contribution, a method of 46 Sc neutron activation analysis was established and tested, by which a detection limit of 0.05 mg soil per g dry plant biomass can be obtained. In the field and greenhouse experiment the mass loading of soil on ryegrass (Lolium perenne L.) and broad bean (Vicia faba L.) was investigated and the contribution from rainsplash and wind erosion were evaluated separately. Soil retained on plant surfaces in field conditions in Seibersdorf/Austria was 5.77 ± 1.44 mg soil per g dry plant for ryegrass and 9.51 ± 0.73 mg soil per g dry plant for broad bean. Estimates of contribution from rainsplash and wind erosion to soil contamination of plant during the experimental period are 68 % and 32 % for broadbean, 47 % and 53 % for ryegrass, respectively. Mass loading results from field studies indicate that soil adhesion on plant surfaces can contribute up to 23 % of plant 137 Cs contamination, the transfer factors modified by mass loading decline differently, depending on 137 Cs concentration of the soil and the soil mass adhered to plant surfaces. (authors)

  17. A study on the evolution of crack networks under thermal fatigue loading

    International Nuclear Information System (INIS)

    Kamaya, Masayuki; Taheri, Said

    2008-01-01

    The crack network is a typical cracking morphology caused by thermal fatigue loading. It was pointed out that the crack network appeared under relatively small temperature fluctuations and did not grow deeply. In this study, the mechanism of evolution of crack network and its influence on crack growth was examined by numerical calculation. First, the stress field near two interacting cracks was investigated. It was shown that there are stress-concentration and stress-shielding zones around interacting cracks, and that cracks can form a network under the bi-axial stress condition. Secondly, a Monte Carlo simulation was developed in order to simulate the initiation and growth of cracks under thermal fatigue loading and the evolution of the crack network. The local stress field formed by pre-existing cracks was evaluated by the body force method and its role in the initiation and growth of cracks was considered. The simulation could simulate the evolution of the crack network and change in number of cracks observed in the experiments. It was revealed that reduction in the stress intensity factor due to stress feature in the depth direction under high cycle thermal fatigue loading plays an important role in the evolution of the crack network and that mechanical interaction between cracks in the network affects initiation rather than growth of cracks. The crack network appears only when the crack growth in the depth direction is interrupted. It was concluded that the emergence of the crack network is preferable for the structural integrity of cracked components

  18. Study on simulation methods of atrium building cooling load in hot and humid regions

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Yiqun; Li, Yuming; Huang, Zhizhong [Institute of Building Performance and Technology, Sino-German College of Applied Sciences, Tongji University, 1239 Siping Road, Shanghai 200092 (China); Wu, Gang [Weldtech Technology (Shanghai) Co. Ltd. (China)

    2010-10-15

    In recent years, highly glazed atria are popular because of their architectural aesthetics and advantage of introducing daylight into inside. However, cooling load estimation of such atrium buildings is difficult due to complex thermal phenomena that occur in the atrium space. The study aims to find out a simplified method of estimating cooling loads through simulations for various types of atria in hot and humid regions. Atrium buildings are divided into different types. For every type of atrium buildings, both CFD and energy models are developed. A standard method versus the simplified one is proposed to simulate cooling load of atria in EnergyPlus based on different room air temperature patterns as a result from CFD simulation. It incorporates CFD results as input into non-dimensional height room air models in EnergyPlus, and the simulation results are defined as a baseline model in order to compare with the results from the simplified method for every category of atrium buildings. In order to further validate the simplified method an actual atrium office building is tested on site in a typical summer day and measured results are compared with simulation results using the simplified methods. Finally, appropriate methods of simulating different types of atrium buildings are proposed. (author)

  19. Abdominal crunch exercise analysis performed with maximum and submaximum loads: An electromyographic study

    Directory of Open Access Journals (Sweden)

    M.L. Moura

    2011-01-01

    Full Text Available The purpose of this study was to verify the electromyographic activity of the rectus abdominis and obliquus externus abdominis during abdominal crunch exercise performed with maximum and submaximum loads. Thirteen male and female university students participated in this investigation (18-23 years old. The subjects completed abdominal crunch exercise until exhaustion with 20, 40, 60 and 80% of the maximum load. The root-mean-square (RMS from electromyography activity of the rectus abdominis and obliquus externus muscles from the first and last three repetitions from each workload performed was analyzed. RMS for the last repetitions increased in relation to the first repetitions for the 20% workload, first two repetitions on 40% workload and first repetition on the 80% workload. There was no difference for the 60% workload. Results showed that external load on abdominal crunch exercise might be an alternative to increase intensity while performing abdominal crunch exercise, which on its turn can be a practical tool for subjects that aim to increase abdominal strength level.

  20. Ratcheting study in pressurized piping components under cyclic loading at room temperature

    International Nuclear Information System (INIS)

    Ravi Kiran, A.; Agrawal, M.K.; Reddy, G.R.; Vaze, K.K.; Ghosh, A.K.; Kushwaha, H.S.

    2006-07-01

    The nuclear power plant piping components and systems are often subjected to reversing cyclic loading conditions due to various process transients, seismic and other events. Earlier the design of piping subjected to seismic excitation was based on the principle of plastic collapse. It is believed that during such events, fatigue-ratcheting is likely mode of failure of piping components. The 1995 ASME Boiler and Pressure Vessel code, Section-III, has incorporated the reverse dynamic loading and ratcheting into the code. Experimental and analytical studies are carried out to understand this failure mechanism. The biaxial ratcheting characteristics of SA 333, Gr. 6 steel and SS 304 stainless steel at room temperature are investigated in the present work. Experiments are carried out on straight pipes subjected to internal pressure and cyclic bending load applied in a three point and four point bend test configurations. A shake table test is also carried out on a pressurized elbow by applying sinusoidal base excitation. Analytical simulation of ratcheting in the piping elements is carried out. Chaboche nonlinear kinematic hardening model is used for ratcheting simulation. (author)

  1. Experimental Study on Reaction Characteristics of PTFE/Ti/W Energetic Materials under Explosive Loading

    Directory of Open Access Journals (Sweden)

    Yan Li

    2016-11-01

    Full Text Available Metal/fluoropolymer composites represent a new category of energetic structural materials that release energy through exothermic chemical reactions initiated under shock loading conditions. This paper describes an experiment designed to study the reaction characteristics of energetic materials with low porosity under explosive loading. Three PTFE (polytetrafluoroethylene/Ti/W mixtures with different W contents are processed through pressing and sintering. An inert PTFE/W mixture without reactive Ti particles is also prepared to serve as a reference. Shock-induced chemical reactions are recorded by high-speed video through a narrow observation window. Related shock parameters are calculated based on experimental data, and differences in energy release are discussed. The results show that the reaction propagation of PTFE/Ti/W energetic materials with low porosity under explosive loading is not self-sustained. As propagation distance increases, the energy release gradually decreases. In addition, reaction failure distance in PTFE/Ti/W composites is inversely proportional to the W content. Porosity increased the failure distance due to higher shock temperature.

  2. The ethos of caring within midwifery: A history of ideas study.

    Science.gov (United States)

    Larsson, Åsa; Hilli, Yvonne

    2016-10-19

    The midwifery profession in Sweden has a history since the early 1700s when government training for midwives began. Midwifery is historically well described, but the idea of caring within midwifery is not described. The aim was to describe the patterns of ideas of caring as they appeared in midwifery during the first half of the 20th century. This study has a hermeneutic approach and the method is history of ideas. Sources of material are taken from the journal Jordemodern (Midwifery), textbooks for midwives, and midwifery regulations. The study has a caring science perspective according to Eriksson. This study is conducted in accordance with the ethical guidelines for good scientific practice issued by The Finnish Advisory Board on Research Integrity. The special demands on approach to the analyzed text in history of ideas have been met. Three themes were identified: Serving as a way of life, Acting in a redemptive spirit, and Having independence with heavy responsibility. The various themes are not refined, but current ideas are woven into the weave that were characteristic of midwifery during the first half of the 20th century. History of ideas is a fruitful method for understanding and re-finding valuable cultural goods. We can once more stress the manner of being within the midwife's profession where inner values, ethos, shape the manner of conduct in the care of women in childbirth. © The Author(s) 2016.

  3. Experimental study on lateral strength of wall-slab joint subjected to lateral cyclic load

    Science.gov (United States)

    Masrom, Mohd Asha'ari; Mohamad, Mohd Elfie; Hamid, Nor Hayati Abdul; Yusuff, Amer

    2017-10-01

    Tunnel form building has been utilised in building construction since 1960 in Malaysia. This method of construction has been applied extensively in the construction of high rise residential house (multistory building) such as condominium and apartment. Most of the tunnel form buildings have been designed according to British standard (BS) whereby there is no provision for seismic loading. The high-rise tunnel form buildings are vulnerable to seismic loading. The connections between slab and shear walls in the tunnel-form building constitute an essential link in the lateral load resisting mechanism. Malaysia is undergoing a shifting process from BS code to Eurocode (EC) for building construction since the country has realised the safety threats of earthquake. Hence, this study is intended to compare the performance of the interior wall slab joint for a tunnel form structure designed based on Euro and British codes. The experiment included a full scale test of the wall slab joint sub-assemblages under reversible lateral cyclic loading. Two sub-assemblage specimens of the wall slab joint were designed and constructed based on both codes. Each specimen was tested using lateral displacement control (drift control). The specimen designed by using Eurocode was found could survive up to 3.0% drift while BS specimen could last to 1.5% drift. The analysis results indicated that the BS specimen was governed by brittle failure modes with Ductility Class Low (DCL) while the EC specimen behaved in a ductile manner with Ductility Class Medium (DCM). The low ductility recorded in BS specimen was resulted from insufficient reinforcement provided in the BS code specimen. Consequently, the BS specimen could not absorb energy efficiently (low energy dissipation) and further sustain under inelastic deformation.

  4. Mechanical stability of immediately loaded implants with various surfaces and designs: a pilot study in dogs.

    Science.gov (United States)

    Neugebauer, Jörg; Weinländer, Michael; Lekovic, Vojislav; von Berg, Karl-Heinz Linne; Zoeller, Joachim E

    2009-01-01

    Immediate loading is among the most innovative techniques in implant therapy today. This pilot study investigates the biomechanical outcome of various designs and surfaces that claim to shorten implant treatment. In each quadrant of two mongrel dogs, four different implants were used for immediate loading. The following implants were placed 3 months after tooth extraction: screw with low thread profile and anodic oxidized surface (LPAOS), solid screw with wide thread profile and titanium plasma spray coating (WPTPS), screw with low profile and hybrid design of double-etched and machined surface (LPHES), and screw with two thread profiles and a sandblasted and acid-etched surface (DTSAE). The insertion torque of each implant was above 35 Ncm. Resonance frequency analysis was performed after implant placement and again after sacrifice. Additionally, the removal torque and the amount of embedded titanium particles in the peri-implant bone were measured. All 16 prostheses were functional after a 5-month loading period. The highest mean removal torque values were recorded with WPTPS implants (24.4 Ncm/mm), followed by DTSAE implants (22.3 Ncm/mm) and LPAOS implants (18.7 Ncm/mm); the lowest score was obtained by LPHES (12.0 Ncm/mm). The ISQ values increased between the time of surgery and recall for all systems on average, but a significant positive correlation was found for DTSAE only. Significantly higher amounts of titanium were found in the surrounding bone with WPTPS (0.76%) and LPAOS (0.41%) in comparison with DTSAE (0.10%) and LPHES (0.03%). Immediate loading is possible with various designs and surfaces if high primary stability can be achieved during implant placement.

  5. Pesticide load dynamics during stormwater flow events in Mediterranean coastal streams: Alexander stream case study.

    Science.gov (United States)

    Topaz, Tom; Egozi, Roey; Eshel, Gil; Chefetz, Benny

    2018-06-01

    Cultivated land is a major source of pesticides, which are transported with the runoff water and eroded soil during rainfall events and pollute riverine and estuarine environments. Common ecotoxicological assessments of riverine systems are mainly based on water sampling and analysis of only the dissolved phase, and address a single pesticide's toxicological impact under laboratory conditions. A clear overview of mixtures of pesticides in the adsorbed and dissolved phases is missing, and therefore the full ecotoxicological impact is not fully addressed. The aim of this study was to characterize and quantify pesticide concentrations in both suspended sediment and dissolved phases, to provide a better understanding of pesticide-load dynamics during storm events in coastal streams in a Mediterranean climate. High-resolution sampling campaigns of seven flood events were conducted during two rainy seasons in Alexander stream, Israel. Samples of suspended sediments were separated from the solution and both media were analyzed separately for 250 pesticides. A total of 63 pesticides were detected; 18 and 16 pesticides were found solely in the suspended sediments and solution, respectively. Significant differences were observed among the pesticide groups: only 7% of herbicide, 20% of fungicide and 42% of insecticide load was transported with the suspended sediments. However, in both dissolved and adsorbed phases, a mix of pesticides was found which were graded from "mobile" to "non-mobile" with varied distribution coefficients. Diuron, and tebuconazole were frequently found in large quantities in both phases. Whereas insecticide and fungicide transport is likely governed by application time and method, the governing factor for herbicide load was the magnitude of the stream discharge. The results show a complex dynamic of pesticide load affected by excessive use of pesticides, which should be taken into consideration when designing projects to monitor riverine and estuarine

  6. Self-Instructional Module Based on Cognitive Load Theory: A Study on Information Retention among Trainee Teachers

    Science.gov (United States)

    Ong, Chiek Pin; Tasir, Zaidatun

    2015-01-01

    The aim of the research is to study the information retention among trainee teachers using a self-instructional printed module based on Cognitive Load Theory for learning spreadsheet software. Effective pedagogical considerations integrating the theoretical concepts related to cognitive load are reflected in the design and development of the…

  7. Immediate loading versus immediate provisionalization of maxillary single-tooth replacements: a prospective randomized study with BioComp implants

    NARCIS (Netherlands)

    Lindeboom, Jerome A.; Frenken, Joost W.; Dubois, Leander; Frank, Michael; Abbink, Ingmar; Kroon, Frans H.

    2006-01-01

    PURPOSE: The aim of this prospective randomized study was to evaluate the clinical outcome of immediately loaded solid plasma sprayed (TPS) BioComp (BioComp Industries BV, Vught, The Netherlands) implants versus immediate provisionalized but non-loaded BioComp implants in the anterior and premolar

  8. Postural stability and history of falls in cognitively able older adults: the Canton Ticino study.

    Science.gov (United States)

    Merlo, Andrea; Zemp, Damiano; Zanda, Enrica; Rocchi, Sabrina; Meroni, Fabiano; Tettamanti, Mauro; Recchia, Angela; Lucca, Ugo; Quadri, Pierluigi

    2012-09-01

    Falls are common events in the elderly and represent the main risk factor for fractures and other injuries. Strategies for fall prevention rely on the multifactorial assessment of the risk of falling. The contribution of instrumented balance assessment to the prediction of falls remains unclear in the literature. In this study, we analyzed the association between the fall-history of a wide sample of older people without dementia and the values of a set of posturographic parameters acquired in different visual, proprioceptive and mental conditions. A consecutive sample of 130 cognitively able elderly subjects, age≥70 years, was analyzed. Based on their fall-history in the last year, subjects were categorized into non-fallers (NF), fallers (F) and recurrent fallers (RF>2 falls). Each subject was assessed by measurements of cognition and functional ability. Static posturography tests were performed in five conditions: with eyes open/close (EO/EC) on a firm/compliant (FS/CS) surface and while performing a cognitive task. The center of pressure (COP) mean position referred to the mid-point of the heels, area of the 95% confidence ellipse, sway mean velocities and RMS displacements in the antero-posterior (AP) and medio-lateral (ML) directions were computed and their association with the fall-history was assessed. The mean position of the COP in the AP direction and the confidence ellipse area were associated with the fall-history in the EOFS, ECFS and EOCS conditions (Pfall-history in the EOCS condition (Pcontrol balance while standing with eyes open on a compliant surface showed a high degree of association with the fall-history of older people with no or mild cognitive impairment. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. Experimental and Model Studies on Loading Path-Dependent and Nonlinear Gas Flow Behavior in Shale Fractures

    Science.gov (United States)

    Li, Honglian; Lu, Yiyu; Zhou, Lei; Tang, Jiren; Han, Shuaibin; Ao, Xiang

    2018-01-01

    Interest in shale gas as an energy source is growing worldwide. Because the rock's natural fracture system can contribute to gas production, it is important to understand the flow behavior of natural fractures in shale. Previous studies on the flow characteristics in shale fractures were limited and did not consider the effect of nonlinearity. To understand the basic mechanics of the gas flow behavior in shale fractures, laboratory investigations with consideration of the fluid pressure gradient, the confining stress, the loading history and the fracture geometry were conducted in this paper. Izbash's equation was used to analyze the nonlinearity of the flow. The results show that the behavior of the friction factors is similar to that shown in flow tests in smooth and rough pipes. The increase of the confining stress and the irreversible damage to the shale decreased the hydraulic aperture and increased the relative roughness. Thus, turbulent flow could appear at a low Reynolds number, resulting in a significant pressure loss. The limits of the cubic law and the existing correction factor for transmissivity are discussed. It is found that the previous friction models overestimate the friction factor in the laminar regime and underestimate the friction factor in the turbulent regime. For this reason, a new friction model based on a linear combination of the Reynolds number and the relative roughness was developed.

  10. A Study of Distributed Generation System Characteristics and Protective Load Control Strategy

    DEFF Research Database (Denmark)

    Wei, Mu; Chen, Zhe

    2011-01-01

    Due to the smaller inertia feature of a Wind Turbine (WT) involved Distributed Generation System (DGS), the WT’s induction generator are more vulnerable to frequency and voltage disturbances. Therefore the study investigates the DGS characteristics respectively from power plants, i.e. WTs and load....... Two kinds of wind turbines: Doubly-fed Induction Generator (DFIG) and Fixed-speed Wind Turbine (FSWT) are compared in this study. A conventional power system protective scheme may not response promptly, which could lead an undesired disconnection of WTs for the turbine protection purpose. Consequently...

  11. Family load estimates and risk factors of anxiety disorders in a nationwide three generation study

    DEFF Research Database (Denmark)

    Helenius, Dorte; Munk-Jørgensen, Povl; Steinhausen, Hans-Christoph

    2014-01-01

    region. Psychiatric diagnoses were also obtained for parents, siblings, and offspring. A family load component was obtained by using various mixed regression models. Anxiety disorders occurred significantly more often in case than in control families. Having a mother, father, or a sibling......The present study investigated how often anxiety disorders with different ages of onset occurred in affected families compared to control families. Furthermore, the study addressed the impact of sex, region of residence, year and month of birth, and parental age at birth. The sample included N=1373......, provide further and solid evidence for the family aggregation of anxiety disorders....

  12. Enhancing Accuracy of Sediment Total Load Prediction Using Evolutionary Algorithms (Case Study: Gotoorchay River

    Directory of Open Access Journals (Sweden)

    K. Roshangar

    2016-09-01

    Full Text Available Introduction: Exact prediction of transported sediment rate by rivers in water resources projects is of utmost importance. Basically erosion and sediment transport process is one of the most complexes hydrodynamic. Although different studies have been developed on the application of intelligent models based on neural, they are not widely used because of lacking explicitness and complexity governing on choosing and architecting of proper network. In this study, a Genetic expression programming model (as an important branches of evolutionary algorithems for predicting of sediment load is selected and investigated as an intelligent approach along with other known classical and imperical methods such as Larsen´s equation, Engelund-Hansen´s equation and Bagnold´s equation. Materials and Methods: In this study, in order to improve explicit prediction of sediment load of Gotoorchay, located in Aras catchment, Northwestern Iran latitude: 38°24´33.3˝ and longitude: 44°46´13.2˝, genetic programming (GP and Genetic Algorithm (GA were applied. Moreover, the semi-empirical models for predicting of total sediment load and rating curve have been used. Finally all the methods were compared and the best ones were introduced. Two statistical measures were used to compare the performance of the different models, namely root mean square error (RMSE and determination coefficient (DC. RMSE and DC indicate the discrepancy between the observed and computed values. Results and Discussions: The statistical characteristics results obtained from the analysis of genetic programming method for both selected model groups indicated that the model 4 including the only discharge of the river, relative to other studied models had the highest DC and the least RMSE in the testing stage (DC= 0.907, RMSE= 0.067. Although there were several parameters applied in other models, these models were complicated and had weak results of prediction. Our results showed that the model 9

  13. Influence of occlusal loading on peri-implant clinical parameters. A pilot study.

    Science.gov (United States)

    Pellicer-Chover, Hilario; Viña-Almunia, José; Romero-Millán, Javier; Peñarrocha-Oltra, David; García-Mira, Berta; Peñarrocha-Diago, María

    2014-05-01

    To investigate the relation between occlusal loading and peri-implant clinical parameters (probing depth, bleeding on probing, gingival retraction, width of keratinized mucosa, and crevicular fluid volume) in patients with implant-supported complete fixed prostheses in both arches. This clinical study took place at the University of Valencia (Spain) dental clinic. It included patients attending the clinic for regular check-ups during at least 12 months after rehabilitation of both arches with implant-supported complete fixed ceramo-metallic prostheses. One study implant and one control implant were established for each patient using the T-Scan®III computerized system (Tesco, South Boston, USA). The maxillary implant closest to the point of maximum occlusal loading was taken as the study implant and the farthest (with least loading) as the control. Occlusal forces were registered with the T-Scan® III and then occlusal adjustment was performed to distribute occlusal forces correctly. Peri-implant clinical parameters were analyzed in both implants before and two and twelve months after occlusal adjustment. Before occlusal adjustment, study group implants presented a higher mean volume of crevicular fluid (51.3 ± 7.4 UP) than the control group (25.8 ± 5.5 UP), with statistically significant difference. Two months after occlusal adjustment, there were no significant differences between groups (24.6 ± 3.8 UP and 26 ± 4.5 UP respectively) (p=0.977). After twelve months, no significant differences were found between groups (24.4 ± 11.1 UP and 22.5 ± 8.9 UP respectively) (p=0.323). For the other clinical parameters, no significant differences were identified between study and control implants at any of the study times (p>0.05). Study group implants receiving higher occlusal loading presented significantly higher volumes of crevicular fluid than control implants. Crevicular fluid volumes were similar in both groups two and twelve months after occlusal adjustment.

  14. Switch Panel wear loading - a parametric study regarding governing train operational factors

    Science.gov (United States)

    Hiensch, E. J. M.; Burgelman, N.

    2017-09-01

    The acting forces and resulting material degradation at the running surfaces of wheels and rail are determined by vehicle, track, interface and operational characteristics. To effectively manage the experienced wear, plastic deformation and crack development at wheels and rail, the interaction between vehicle and track demands a system approach both in maintenance and in design. This requires insight into the impact of train operational parameters on rail- and wheel degradation, in particular at switches and crossings due to the complex dynamic behaviour of a railway vehicle at a turnout. A parametric study was carried out by means of vehicle-track simulations within the VAMPIRE® multibody simulation software, performing a sensitivity analysis regarding operational factors and their impact on expected switch panel wear loading. Additionally, theoretical concepts were cross-checked with operational practices by means of a case study in response to a dramatic change in lateral rail wear development at specific switches in Dutch track. Data from train operation, track maintenance and track inspection were analysed, providing further insight into the operational dependencies. From the simulations performed in this study, it was found that switch rail lateral wear loading at the diverging route of a 1:9 type turnout is significantly influenced by the level of wheel-rail friction and to a lesser extent by the direction of travel (facing or trailing). The influence of other investigated parameters, being vehicle speed, traction, gauge widening and track layout is found to be small. Findings from the case study further confirm the simulation outcome. This research clearly demonstrates the contribution flange lubrication can have in preventing abnormal lateral wear at locations where the wheel-rail interface is heavily loaded.

  15. Preparation and Comparative Bioavailability Studies of Indomethacin-Loaded Cetyl Alcohol Microspheres

    Directory of Open Access Journals (Sweden)

    N. Vishal Gupta

    2013-01-01

    Full Text Available The purpose of the present study was to compare the in vitro release and to find out whether the bioavailability of a 75 mg indomethacin capsule (Microcid SR was equivalent to optimized formulation (indomethacin-loaded cetyl alcohol microspheres. Indomethacin-loaded cetyl alcohol microspheres were prepared by meltable emulsified cooling-induced technique. Surface morphology of microspheres has been evaluated using scanning electron microscopy. A single dose, randomized, complete cross over study of IM microspheres was carried out on 10 healthy male and female Albino sheep’s under fasting conditions. The plasma was separated and the concentrations of the drug were determined by HPLC-UV method. Plasma indomethacin concentrations and other pharmacokinetic parameters obtained were statistically analyzed. The SEM images revealed the spherical shape of fat microspheres, and more than 98.0% of the isolated microspheres were in the size range 12–32 μm. DSC, FTIR spectroscopy and stability studies indicated that the drug after encapsulation with fat microspheres was stable and compatible. Both formulations were found to be bioequivalent as evidenced by in vivo studies. Based on this study, it can be concluded that cetyl alcohol microspheres and Microcid SR capsule are bioequivalent in terms of the rate and extent of absorption.

  16. Biomechanical evaluation of an integrated fixation cage during fatigue loading: a human cadaver study.

    Science.gov (United States)

    Palepu, Vivek; Peck, Jonathan H; Simon, David D; Helgeson, Melvin D; Nagaraja, Srinidhi

    2017-04-01

    OBJECTIVE Lumbar cages with integrated fixation screws offer a low-profile alternative to a standard cage with anterior supplemental fixation. However, the mechanical stability of integrated fixation cages (IFCs) compared with a cage with anterior plate fixation under fatigue loading has not been investigated. The purpose of this study was to compare the biomechanical stability of a screw-based IFC with a standard cage coupled with that of an anterior plate under fatigue loading. METHODS Eighteen functional spinal units were implanted with either a 4-screw IFC or an anterior plate and cage (AP+C) without integrated fixation. Flexibility testing was conducted in flexion-extension (FE), lateral bending (LB), and axial rotation (AR) on intact spines, immediately after device implantation, and post-fatigue up to 20,000 cycles of FE loading. Stability parameters such as range of motion (ROM) and lax zone (LZ) for each loading mode were compared between the 2 constructs at multiple stages of testing. In addition, construct loosening was quantified by subtracting post-instrumentation ROM from post-fatigue ROM. RESULTS IFC and AP+C configurations exhibited similar stability (ROM and LZ) at every stage of testing in FE (p ≥ 0.33) and LB (p ≥ 0.23) motions. In AR, however, IFCs had decreased ROM compared with AP+C constructs at pre-fatigue (p = 0.07) and at all post-fatigue time points (p ≤ 0.05). LZ followed a trend similar to that of ROM in AR. ROM increased toward intact motion during fatigue cycling for AP+C and IFC implants. IFC specimens remained significantly (p < 0.01) more rigid than specimens in the intact condition during fatigue for each loading mode, whereas AP+C construct motion did not differ significantly (p ≥ 0.37) in FE and LB and was significantly greater (p < 0.01) in AR motion compared with intact specimens after fatigue. Weak to moderate correlations (R 2 ≤ 56%) were observed between T-scores and construct loosening, with lower T

  17. Immediate functional loading of provisional implants in the reconstructed atrophic maxilla: preliminary results of a prospective study after 6 months of loading with a provisional bridge.

    Science.gov (United States)

    Lenssen, O; Barbier, L; De Clercq, C

    2011-09-01

    Implant-prosthetic rehabilitation of atrophic maxillae remains a challenging problem. The aim of this paper is to describe a novel treatment for functional rehabilitation of the atrophic maxilla and to discuss preliminary results of this treatment protocol. A prospective pilot study was carried out in 10 patients who underwent bony reconstruction of atrophic maxillae under general anaesthesia, with autologous calvarial bone grafts and simultaneous placement of six provisional implants. The provisional implants were loaded with a provisional acrylic bridge 1 day after surgery. After 6 months, the provisional implants were removed and final implants were placed under local anaesthesia, again in an immediate loading concept with a provisional bridge, followed by a final bridge after another 6 months of healing. The bone grafts integrated well in all 10 patients without infectious complications. The prosthetic survival of the provisional bridge at the time of placing the implants was 100%. All final implants could be placed and immediately loaded with a second provisional bridge. Patient satisfaction was high due to limited postoperative inconvenience and immediate fixed prosthetic rehabilitation. The preliminary results of this pilot study demonstrate that this treatment protocol is a well tolerated treatment for patients with maxillary atrophy desiring dental rehabilitation. Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  18. Drug elution from high-dose antibiotic-loaded acrylic cement: a comparative, in vitro study.

    Science.gov (United States)

    Gasparini, Giorgio; De Gori, Marco; Calonego, Giovanni; Della Bora, Tommaso; Caroleo, Benedetto; Galasso, Olimpio

    2014-11-01

    High-dose antibiotic-loaded acrylic cement (ALAC) is used for managing peri-prosthetic joint infections (PJIs). The marked increase in resistant high-virulence bacteria is drawing the attention of physicians toward alternative antimicrobial formulations loaded into acrylic bone cement. The aim of this in vitro study was to determine the elution kinetics of 14 different high-dose ALACs. All ALAC samples showed a burst release of antibiotics in the first hour, progressively decreasing over time, and elution curves strictly adhered to a nonlinear regression analysis formula. Among aminoglycosides, commonly seen as the most appropriate antibiotics to be loaded into the bone cement, the highest elution rate was that of tobramycin. Among the glycopeptides, a class of antibiotics that should be considered to treat PJIs because of the prevalence of aminoglycoside resistance, vancomycin showed better elution than teicoplanin. Clindamycin, which can be associated with aminoglycosides to prepare ALACs and represents a useful option against the most common pathogens responsible for PJIs, showed the highest absolute and relative elutions among all the tested formulations. A noticeable elution was also detected for colistin, an antibiotic of last resort for treating multidrug-resistant bacteria. The current study demonstrates theoretical advantages in the preparation of ALAC for some antibiotics not routinely used in the clinical setting for PJIs. The use of these antibiotics based on the infecting bacteria sensitivity may represent a useful option for physicians to eradicate PJIs. In vivo testing should be considered in the future to confirm the results of this study. Copyright 2014, SLACK Incorporated.

  19. Can bed-load help to validate hydrology studies in mountainous catchment? The case study of the Roize (Voreppe, France

    Directory of Open Access Journals (Sweden)

    Piton Guillaume

    2016-01-01

    Full Text Available Larges uncertainties are attached to hazard prediction in mountain streams, because of some limitations in our knowledge of physical processes, and overall, because of the lack of measurements for validation. This is particularly true for hydrological data, making the hydrology assessment of a mountain river a very difficult task, usually associated with large uncertainties. On the other hand, contrarily to lowland rivers, bed-load in mountain streams is often trapped in mitigation-structures, such as open check dams. This study aims to take advantage of these additional information for compensating the general lack of hydrological data, in order to converge toward a comprehensive diagnosis of the catchment hydrological behavior. A hydrology and sediment transport study has been done on the Roize torrent (16.1-km2 - Voreppe - 38-FR. After a classical historical study, a regional analysis of raingauges and water-discharge-stations situated in the calcareous north Pre-Alps massifs of the Vercors, Chartreuse and Bauges has been done. A catchment geomorphology study has been performed to get insight about the Roize torrential activity and sediment transport. The volumes of bed-load transported each year on average and during extreme floods have been computed using the estimated hydrology. The good bed-load predictions compare to the volume dredged in the Voreppe sediment trap are considered an indirect validation of the hydrology study.

  20. Psychological impact of family history risk assessment in primary care: a mixed methods study.

    Science.gov (United States)

    Birt, Linda; Emery, Jon D; Prevost, A Toby; Sutton, Stephen; Walter, Fiona M

    2014-08-01

    Routine family history risk assessment for chronic diseases could enable primary care practitioners to efficiently identify at-risk patients and promote preventive management strategies. To investigate patients' understanding and responses to family history risk assessment in primary care. A mixed methods study set in 10 Eastern England general practices. Participants in a family history questionnaire validation study were triaged into population or increased risk for four chronic diseases (type 2 diabetes, cardiovascular disease, breast cancer, colorectal cancer). Questionnaires completed immediately prior to the family history consultation (baseline) and 4 weeks later (follow-up) assessed the psychological impact, including State-Trait Anxiety Inventory scores. Semi-structured interviews explored the meaning participants gave to their personal familial disease risk. Four hundred and fifty-three participants completed both baseline and follow-up questionnaires and 30 were interviewed. At follow-up, there was no increase in anxiety among either group, or differences between the groups [difference in mean change 0.02, 95% confidence interval -2.04, 2.08, P = 0.98]. There were no significant changes over time in self-rated health in either group. At follow-up, participants at increased risk (n = 153) were more likely to have recent changes to behaviour and they had stronger intentions to make changes to diet (P = 0.001), physical activity (P = 0.006) and to seek further information in the future than those at population risk (n = 300; P assessment for familial risk of chronic diseases may be undertaken in primary care without causing anxiety or reducing self-rated health. Patient responses to family history risk assessment may inform promotion of preventive management strategies. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Effect of thermo-mechanical loading histories on fatigue crack growth behavior and the threshold in SUS 316 and SCM 440 steels. For prevention of high cycle thermal fatigue failures

    International Nuclear Information System (INIS)

    Okazaki, Masakazu; Muzvidziwa, Milton; Iwasaki, Akira; Kasahara, Naoto

    2014-01-01

    High cycle thermal fatigue failure of pipes induced by fluid temperature change is one of the interdisciplinary issues to be concerned for long term structural reliability of high temperature components in energy systems. In order to explore advanced life assessment methods to prevent the failure, fatigue crack propagation tests were carried out in a low alloy steel and an austenitic stainless steel under typical thermal and thermo-mechanical histories. Special attention was paid to both the effect of thermo-mechanical loading history on the fatigue crack threshold, as well as to the applicability of continuum fracture mechanics treatment to small or short cracks. It was shown experimentally that the crack-based remaining fatigue life evaluation provided more reasonable assessment than the traditional method based on the semi-empirical law in terms of 'usage factor' for high cycle thermal fatigue failure that is employed in JSME Standard, S017. The crack propagation analysis based on continuum fracture mechanics was almost successfully applied to the small fatigue cracks of which size was comparable to a few times of material grain size. It was also shown the thermo-mechanical histories introduced unique effects to the prior fatigue crack wake, resulting in occasional change in the fatigue crack threshold. (author)

  2. What is the history of my house? An integrated appraoch between geology, archaeology, history and heritage studies

    Science.gov (United States)

    Kluiving, Sjoerd; van Gelder, Ronald; Schmidt, Freek

    2017-04-01

    What is the history of my house? In what kind of architectural style was the house (re-)built and by whom? Who were the former inhabitants of my house and what is known about them? What other historic facts are known of the house or street in which I live? On what natural and/or cultural substrate is my house built and which processes can be reconstructed? Could traces of older inhabitants of this place be found underneath my house? These questions are both practically and theoretically relevant, for inhabitants of our society and for use and knowledge in science. Who could answer such detailed questions about your own house? Of course heritage scientists, historians, archaeologists, soil scientists and geologists could answer part of these questions, but an integrated overview that summarises all relevant historical, cultural and natural data of the most special place of people in general is lacking until today. What kind of story has the house and soil underneath my home to tell? To enable a wider public to discover the 'big' history of their private homes, we envision an integrated tool needs to be developed that 'harvests' publicly available digital data from cadastres, cultural heritage institutions and databases with a large variety of information. The specific digital aspects that are the objective of this project is the writing of an app/program that summarises these interdisciplinary data of local circumstances retrieved from e.g. a central server. We aim specifically to get information from databases with a spatial component that can link thematic data to x,y z coordinates. A diverse heterogeneous digital data set cannot be queried easily, therefore a sophisticated and up-to-date app or computer program needs to be developed. The end goal of this app/program should be an easy to reach overview of interdisciplinary data retrieved from a given location or any other smaller spatial scale that is feasible and stored on a central server. We present the results

  3. A study on the load distribution factor in the perforated square plate with elastic support

    International Nuclear Information System (INIS)

    Lee, Y.S.; Yim, J.S.

    1993-01-01

    The load distribution factor in the perforated square plate supporting by angle shape legs under concentrated load acting at arbitrary points through elastic media is calculated. For the calculation the perforated plate was converted into an orthotropic plate using the method suggested by J.B. Mahoney. The deflection for the calculation of the load distribution factor was obtained from the auxiliary plate which was extended both sides of the plate and it was compared with the results from ANSYS calculation. With this deflection, the calculation of the load distribution factor was performed. The result shows that the load distribution factor at the periphery of the plate is larger than that of in the central location. This load distribution factor could be used for re-distribution of the applied load in more accurate analysis of the plate as well as in the analysis of the elastic media as the load factor. (author)

  4. Stability Estimates for a Twisted Rod Under Terminal Loads: A Three-dimensional Study

    KAUST Repository

    Majumdar, Apala

    2012-03-01

    The stability of an inextensible unshearable elastic rod with quadratic strain energy density subject to end loads is considered. We study the second variation of the corresponding rod-energy, making a distinction between in-plane and out-of-plane perturbations and isotropic and anisotropic cross-sections, respectively. In all cases, we demonstrate that the naturally straight state is a local energy minimizer in parameter regimes specified by material constants. These stability results are also accompanied by instability results in parameter regimes defined in terms of material constants. © 2012 Springer Science+Business Media B.V.

  5. A micromechanical study of porous composites under longitudinal shear and transverse normal loading

    DEFF Research Database (Denmark)

    Ashouri Vajari, Danial

    2015-01-01

    The mechanical response of porous unidirectional composites under transverse normal and longitudinal shear loading is studied using the finite element analysis. The 3D model includes discrete and random distribution of fibers and voids. The micromechanical failure mechanisms are taken into account....... Finally, the computational prediction of the porous composite in the transverse normal-longitudinal shear stress space is obtained and compared with Puck's model. The results show that both interfaces with low fracture toughness and microvoids with even small void volume fraction can significantly reduce...

  6. Superconducting magnetic energy storage for electric utility load leveling: A study of cost vs. stored energy

    International Nuclear Information System (INIS)

    Luongo, C.A.; Loyd, R.J.

    1987-01-01

    Superconducting Magnetic Energy Storage (SMES) is a promising technology for electric utility load leveling. This paper presents the results of a study to establish the capital cost of SMES as a function of stored energy. Energy-related coil cost and total installed plant cost are given for construction in nominal soil and in competent rock. Economic comparisons are made between SMES and other storage technologies and peaking gas turbines. SMES is projected to be competitive at stored energies as low as 1000 MWh

  7. Study of loading by beam of dual-resonator structure of linear electron accelerator

    International Nuclear Information System (INIS)

    Milovanov, O.S.; Smirnov, I.A.

    1988-01-01

    Loading by the beam of the accelerating structure of an Argus dual-resonator linear electron accelerator with a kinetic energy of ∼ 1 MeV and a pulsed beam current of up to 0.5 A is studied experimentally. It is shown that the conditions for stable single-frequency operation of the magnetron are disrupted and the acceleration process is cut off at certain electron-beam currents. Experimental curves of the maximum beam current and maximum electron efficiency of the Argus linear electron accelerator as functions of rf power are given

  8. Study of the effect of gamma irradiation on carbon black loaded low-density polyethylene films

    International Nuclear Information System (INIS)

    Salem, M.A.; Hussein, A.; El-Ahdal, M.A.

    2003-01-01

    The effect of gamma irradiation on the tensile and physico-chemical properties of low-density polyethylene (LDPE) films loaded with different concentrations of carbon black (C.B) has been studied. The results showed that the behavior of the samples during gamma irradiation is complicated and this may be due to scission and the interaction between oxidation and crosslinking processes. The tensile properties are modified by the presence of carbon black. Film sample containing 7% C.B was found to exhibit a nearly stabilized tensile behavior with radiation dose, which allows to use this formulation in packaging for food sterilization and in preservation of weak cobalt-gamma sources. (author)

  9. Stability Estimates for a Twisted Rod Under Terminal Loads: A Three-dimensional Study

    KAUST Repository

    Majumdar, Apala; Prior, Christopher; Goriely, Alain

    2012-01-01

    The stability of an inextensible unshearable elastic rod with quadratic strain energy density subject to end loads is considered. We study the second variation of the corresponding rod-energy, making a distinction between in-plane and out-of-plane perturbations and isotropic and anisotropic cross-sections, respectively. In all cases, we demonstrate that the naturally straight state is a local energy minimizer in parameter regimes specified by material constants. These stability results are also accompanied by instability results in parameter regimes defined in terms of material constants. © 2012 Springer Science+Business Media B.V.

  10. Effects of load and thermal histories on mechanical behavior of materials; Proceedings of the Symposium, Denver, CO, Feb. 25, 26, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Liaw, P.K.; Nicholas, T.

    1987-01-01

    This volume includes topics on fatigue crack propagation; isothermal and thermal-mechanical fatigue; and microstructure, fracture, and damage. Papers are presented on transients in fatigue crack growth, elevated-temperature fatigue crack propagation, the role of crack closure in crack retardation in P/M and I/M aluminum alloys, the acoustic interrogation of fatigue overload effects, and the effects of frequency and environment on crack growth in Inconel 718. Special attention is given to isothermal fatigue failure mechanisms in low-tin lead-based solder, the stress and strain controlled low-cycle fatigue of Pb-Sn solder for electronic packaging applications, load sequence effects on the deformation of isolated microplastic grains, and thermal fatigue of stainless steel. Other papers are on the influence of thermal aging on the creep crack growth behavior of a Cr-Mo steel, the effect of cyclic loading on the fracture toughness of a modified 4340 steel, and the effects of hot rolling condition and boron microalloying on phase transformation and microstructure in niobium-bearing interstitial free steel.

  11. A Comparative Study of Load Balancing Algorithms in Cloud Computing Environment

    OpenAIRE

    Katyal, Mayanka; Mishra, Atul

    2014-01-01

    Cloud Computing is a new trend emerging in IT environment with huge requirements of infrastructure and resources. Load Balancing is an important aspect of cloud computing environment. Efficient load balancing scheme ensures efficient resource utilization by provisioning of resources to cloud users on demand basis in pay as you say manner. Load Balancing may even support prioritizing users by applying appropriate scheduling criteria. This paper presents various load balancing schemes in differ...

  12. Phylogeny and Historical Biogeography of Acer I-Study History of the Infrageneric Classification(1

    Directory of Open Access Journals (Sweden)

    Shing-Fan Huang

    2002-09-01

    Full Text Available Historical biogeography is a study of taxa in time and space including their origin, migration and diversification. This kind of study requires fossil data and an understanding of phylogenetic relationships. These requirements make Acer a good model to study because Acer 1 has a relatively complete fossil record, 2 contains many species, 3 is a major northern temperate floristic element, and 4 is well known. Because fossils are only confidently assigned to section or species group, section as a unit is suitable for tracing evolutionary history of Acer. However, the circumscription of section of Acer is different to each classification through the long history of studies. This work reviews and summarizes the studying history of Acer. Delendick in 1981concluded that the system of Ogata in 1967 and that of Jong in 1976 were superior to others except that most Jong’s series should be raised to section. This work, therefore, follows Delendick’s delineation of section except Distyla and Parviflora, which are combined as Parviflora, to elucidate the development of the circumscription of section based on the system of Pax in 1885 and 1886, Pojarkova in 1933, Momotani in 1962, Fang in 1966, Ogata in 1967, Murray in 1970, Jong in 1976, Delendick in 1990 and Xu in 1996.

  13. A Study of Gender and Performance on Advanced Placement History Examinations. College Board Report No. 91-4.

    Science.gov (United States)

    Breland, Hunter M.; And Others

    Several studies have shown that, on average, women perform slightly better than men on free-response tests, while men perform slightly better on multiple-choice tests. Two advanced placement examinations, United States History (USH) and European History (EH), were chosen for study because previous studies have shown that sex differences on the…

  14. The effects of mechanical loading on tendons--an in vivo and in vitro model study.

    Directory of Open Access Journals (Sweden)

    Jianying Zhang

    Full Text Available Mechanical loading constantly acts on tendons, and a better understanding of its effects on the tendons is essential to gain more insights into tendon patho-physiology. This study aims to investigate tendon mechanobiological responses through the use of mouse treadmill running as an in vivo model and mechanical stretching of tendon cells as an in vitro model. In the in vivo study, mice underwent moderate treadmill running (MTR and intensive treadmill running (ITR regimens. Treadmill running elevated the expression of mechanical growth factors (MGF and enhanced the proliferative potential of tendon stem cells (TSCs in both patellar and Achilles tendons. In both tendons, MTR upregulated tenocyte-related genes: collagen type I (Coll. I ∼10 fold and tenomodulin (∼3-4 fold, but did not affect non-tenocyte-related genes: LPL (adipocyte, Sox9 (chondrocyte, Runx2 and Osterix (both osteocyte. However, ITR upregulated both tenocyte (Coll. I ∼7-11 fold; tenomodulin ∼4-5 fold and non-tenocyte-related genes (∼3-8 fold. In the in vitro study, TSCs and tenocytes were stretched to 4% and 8% using a custom made mechanical loading system. Low mechanical stretching (4% of TSCs from both patellar and Achilles tendons increased the expression of only the tenocyte-related genes (Coll. I ∼5-6 fold; tenomodulin ∼6-13 fold, but high mechanical stretching (8% increased the expression of both tenocyte (Coll. I ∼28-50 fold; tenomodulin ∼14-48 fold and non-tenocyte-related genes (2-5-fold. However, in tenocytes, non-tenocyte related gene expression was not altered by the application of either low or high mechanical stretching. These findings indicate that appropriate mechanical loading could be beneficial to tendons because of their potential to induce anabolic changes in tendon cells. However, while excessive mechanical loading caused anabolic changes in tendons, it also induced differentiation of TSCs into non-tenocytes, which may lead to the development

  15. Training Load, Immune Status, and Clinical Outcomes in Young Athletes: A Controlled, Prospective, Longitudinal Study

    Science.gov (United States)

    Blume, Katharina; Körber, Nina; Hoffmann, Dieter; Wolfarth, Bernd

    2018-01-01

    Introduction: Beside positive effects on athlete's health, competitive sport can be linked with an increased risk of illness and injury. Because of high relative increases in training, additional physical and psychological strains, and an earlier specialization and professionalization, adolescent athletes needs an increased attention. Training can alter the immune system by inducing a temporary immunosuppression, finally developing infection symptoms. Previous studies identified Epstein Barr Virus (EBV) as potential indicator for the immune status. In addition to the identification of triggering risk factors for recurrent infections, the aim was to determine the interaction between training load, stress sense, immunological parameters, and clinical symptoms. Methods: A controlled, prospective, longitudinal study on young athletes (n = 274, mean age: 13.8 ± 1.5 yrs) was conducted between 2010 and 2014. Also 285 controls (students, who did not perform competitive sports, mean age: 14.5 ± 1.9 yrs) were recruited. Athletes were examined 3 times each year to determine the effects of stress factors (training load: training hours per week [Th/w]) on selected outcome parameters (clinical [susceptibility to infection, WURSS-21: 21-item Wisconsin Upper Respiratory Symptom Survey], immunological, psychological end points). As part of each visit, EBV serostatus and EBV-specific IgG tiers were studied longitudinally as potential immune markers. Results: Athletes (A) trained 14.9 ± 5.6 h weekly. Controls (C) showed no lower stress levels compared to athletes (p = 0.387). Twelve percent of athletes reported recurrent infections (C: 8.5%, p = 0.153), the presence of an upper respiratory tract infection (URTI) was achieved in 30.7%. EBV seroprevalence of athletes was 60.3% (C: 56.6%, p = 0.339). Mean EBV-specific IgG titer of athletes was 166 ± 115 U/ml (C: 137 ± 112 U/ml, p = 0.030). With increasing Th/w, higher stress levels were observed (p athletes showed no increased

  16. History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany)

    DEFF Research Database (Denmark)

    Berg-Beckhoff, Gabriele; Schüz, Joachim; Blettner, Maria

    2009-01-01

    The aim of the present analysis was to examine the association of a medical history of asthma, hay fever, eczema, or epilepsy with the risk of glioma and meningioma. Data of a German population-based case-control study included 381 meningioma cases, 366 glioma cases, and 1,494 controls...... occurring more than a decade before the diagnosis of glioma, this might indicate either an aetiological role of epilepsy, or a relatively long preclinical phase. In conclusion our study confirms previous findings of case control studies but not those from cohort studies. However, possible selection bias...... in case control studies might not explain the different results in its entirety....

  17. Training Load, Immune Status, and Clinical Outcomes in Young Athletes: A Controlled, Prospective, Longitudinal Study

    Directory of Open Access Journals (Sweden)

    Katharina Blume

    2018-03-01

    Full Text Available Introduction: Beside positive effects on athlete's health, competitive sport can be linked with an increased risk of illness and injury. Because of high relative increases in training, additional physical and psychological strains, and an earlier specialization and professionalization, adolescent athletes needs an increased attention. Training can alter the immune system by inducing a temporary immunosuppression, finally developing infection symptoms. Previous studies identified Epstein Barr Virus (EBV as potential indicator for the immune status. In addition to the identification of triggering risk factors for recurrent infections, the aim was to determine the interaction between training load, stress sense, immunological parameters, and clinical symptoms.Methods: A controlled, prospective, longitudinal study on young athletes (n = 274, mean age: 13.8 ± 1.5 yrs was conducted between 2010 and 2014. Also 285 controls (students, who did not perform competitive sports, mean age: 14.5 ± 1.9 yrs were recruited. Athletes were examined 3 times each year to determine the effects of stress factors (training load: training hours per week [Th/w] on selected outcome parameters (clinical [susceptibility to infection, WURSS-21: 21-item Wisconsin Upper Respiratory Symptom Survey], immunological, psychological end points. As part of each visit, EBV serostatus and EBV-specific IgG tiers were studied longitudinally as potential immune markers.Results: Athletes (A trained 14.9 ± 5.6 h weekly. Controls (C showed no lower stress levels compared to athletes (p = 0.387. Twelve percent of athletes reported recurrent infections (C: 8.5%, p = 0.153, the presence of an upper respiratory tract infection (URTI was achieved in 30.7%. EBV seroprevalence of athletes was 60.3% (C: 56.6%, p = 0.339. Mean EBV-specific IgG titer of athletes was 166 ± 115 U/ml (C: 137 ± 112 U/ml, p = 0.030. With increasing Th/w, higher stress levels were observed (p < 0.001. Analyzes of WURSS

  18. Reliability of Baropodometry on the Evaluation of Plantar Load Distribution: A Transversal Study.

    Science.gov (United States)

    Baumfeld, Daniel; Baumfeld, Tiago; da Rocha, Romário Lopes; Macedo, Benjamim; Raduan, Fernando; Zambelli, Roberto; Alves Silva, Thiago Alexandre; Nery, Caio

    2017-01-01

    Introduction . Baropodometry is used to measure the load distribution on feet during rest and walking. The aim of this study was to evaluate changes in plantar foot pressures distribution due to period of working and due to stretching exercises of the posterior muscular chain. Methods . In this transversal study, all participants were submitted to baropodometric evaluation at two different times: before and after the working period and before and after stretching the muscles of the posterior chain. Results . We analyzed a total of 54 feet of 27 participants. After the working period, there was an average increase in the forefoot pressure of 0.16 Kgf/cm 2 and an average decrease in the hindfoot pressure of 0.17 Kgf/cm 2 . After stretching the posterior muscular chain, the average increase in the forefoot pressure was 0.56 Kgf/cm 2 and the hindfoot average pressure decrease was 0.56 Kgf/cm 2 . These changes were not statistically significant. Discussion . It was reported that the strength of the Achilles tendon generates greater forefoot load transferred from the hindfoot. In our study, no significant variation in the distribution of plantar pressure was observed. It can be inferred that baropodometry was a reliable instrument to determine the plantar pressure, regardless of the tension of the posterior chain muscles.

  19. An experimental study on the resistance and movement of short pile installed in sands under horizontal pullout load

    Directory of Open Access Journals (Sweden)

    Oh Kyun Kwon

    2014-03-01

    Full Text Available In this study, the model tests were conducted on the short piles installed in sands under a horizontal pullout load to investigate their behavior characteristics. From the horizontal loading tests where dimensions of the pile diameter and length, and loading point were varied, the horizontal pullout resistance and the rotational and translational movement pattern of the pile were investigated. As a result, the horizontal pullout resistance of the pile embedded in sands was dependent on the pile length, diameter, loading point, etc. The ultimate horizontal pullout load tended to increase as the loading point (h/L moved to the bottom from the top of the pile, regardless of the ratio between the pile length and diameter (L/D, reached the maximum value at the point of h/L = 0.75, and decreased afterwards. When the horizontal pullout load acted on the upper part above the middle of the pile, the pile rotated clockwise and moved to the pullout direction, and the pivot point of the pile was located at 150–360mm depth below the ground surface. On the other hand, when the horizontal pullout load acted on the lower part of the pile, the pile rotated counterclockwise and travelled horizontally, and the rotational angle was very small.

  20. The Lexicon of Development: A Quantitative History of the Language of Development Studies

    Directory of Open Access Journals (Sweden)

    Christopher David ABSELL

    2015-05-01

    Full Text Available The objective of this article is to examine the history of the language of development theory in order to elucidate the nature of its terminology. The history of the principal terms of development theory (economic/sustainable/human development, Third World, and North/(Global South is examined by way of a quantitative study of the frequency of the usage of these terms during the 20th century based on a dataset of millions of digitised books made available by Google Books. The author argues that the results of the study provide empirical evidence that the language of development theory is a historical-ideological construction which is embedded in the structure of the world economy.

  1. [Information production by scientists and the history of science: typological study of personal archives].

    Science.gov (United States)

    Silva, Maria Celina Soares de Mello E; Trancoso, Márcia Cristina Duarte

    2015-01-01

    This article addresses the study of document typology in the personal archives of scientists and its importance in the history of science studies and for the archivist's work. A brief history is presented of diplomatic to typological information, emphasizing that identifying document production activity as essential for its classification. The article illustrates personal archive characteristics as regards the diversity of documental types and, in particular, those belonging to physicists. Furthermore, it presents five examples of documental types found in the archives of physicists as examples of research in progress. It also highlights the elaboration of a glossary of different documental kinds and types found in the private archives of Museum of Astronomy and Related Sciences in Rio de Janeiro.

  2. Survival rates and bone loss after immediate loading of implants in fresh extraction sockets (single gaps). A clinical prospective study with 4 year follow-up

    Science.gov (United States)

    Wojtovicz, Eduardo; España-Lopez, Antonio; Jimenez-Guerra, Alvaro; Monsalve-Guil, Loreto; Ortiz-Garcia, Ivan; Serrera-Figallo, Maria-Angeles

    2018-01-01

    Background The aim of this prospective study was to report the outcome of treatment with implants inserted after tooth extraction and immediately loaded. Material and Methods Fifty-six patients with single tooth loss were treated with 116 IPX Galimplant® implants with internal connections and a sandblasted, acid-etched surface. All implants were placed after tooth extraction using a flapless approach without bone regeneration, and they were then immediately loaded with cemented acrylic prostheses. After a period of three months, definitive cemented ceramic prostheses were placed. Patients were examined throughout a total of 4 years of follow-up. Marginal bone loss and survival rates were evaluated using digital periapical radiographs, taking into account clinical variables such as age, gender, smoking, history of periodontitis, etiology of extraction, placement site, diameter, and implant length. The Mann-Whitney U and Kruskal-Wallis non-parametric tests were used to compare differences between subgroups created based on the different clinical variables identified. Results Clinical results indicate an implant survival and success rate of 97.4%. Three implants were lost. Of the 116 immediate acrylic single crowns initially placed, 113 were replaced with definitive ceramic crowns after 3 months. A total of 77.8% of implants were inserted in the maxilla, while 22.2% were inserted in the mandible. No further complications were reported after the follow-up period (4 years). The mean marginal bone loss was 0.67 mm ± 0.40 mm. No differences were found among the subgroups of study patients. Conclusions This study indicates that dental implants that are inserted after tooth extraction and immediately loaded may constitute a successful and predictable alternative implant treatment. Key words:Dental implants, post-extraction implants, fresh sockets, immediate loading, immediate prostheses, implant dentistry. PMID:29476669

  3. Experimental studies of breaking of elastic tired wheel under variable normal load

    Science.gov (United States)

    Fedotov, A. I.; Zedgenizov, V. G.; Ovchinnikova, N. I.

    2017-10-01

    The paper analyzes the braking of a vehicle wheel subjected to disturbances of normal load variations. Experimental tests and methods for developing test modes as sinusoidal force disturbances of the normal wheel load were used. Measuring methods for digital and analogue signals were used as well. Stabilization of vehicle wheel braking subjected to disturbances of normal load variations is a topical issue. The paper suggests a method for analyzing wheel braking processes under disturbances of normal load variations. A method to control wheel baking processes subjected to disturbances of normal load variations was developed.

  4. Four Tools for Critical Inquiry in History, Social Studies, and Civic Education

    OpenAIRE

    Bermudez, Angela

    2015-01-01

    The promotion of critical thinking is an important but elusive goal in history, social studies, and civic education. Teachers often struggle to translate general definitions of critical thinking into specific pedagogical tools to plan learning activities and to observe and interpret student work in these subjects. They also struggle to distinguish between "teaching critical content" and "teaching students to think critically." In this paper, I draw upon scholarship on critical thinking, histo...

  5. A Qualitative Natural History Study of ME/CFS in the Community

    OpenAIRE

    Anderson, Valerie R.; Jason, Leonard A.; Hlavaty, Laura E.

    2013-01-01

    In previous qualitative research on Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS), researchers have focused on the experiences of patients with ME/CFS in tertiary care samples, which limit the representativeness of the findings to those with access to health care. This qualitative study examined the natural history of a community-based sample of people with ME/CFS. Participants (n=19) were categorized into persisting, incidence, or remitting groups based on their reported illnes...

  6. The History of Technology in Education. A Comparative Study and Forecast

    OpenAIRE

    del Campo, Jose María; Negro, Vicente; Núñez, Miguel

    2012-01-01

    Area, launched in 1999 with the Bologna Declaration, has bestowed such a magnitude and unprecedented agility to the transformation process undertaken by European universities. However, the change has been more profound and drastic with regards to the use of new technologies both inside and outside the classroom. This article focuses on the study and analysis of the technology’s history within the university education and its impact on teachers, students and teaching methods. A...

  7. Photolysis study of octyl p-methoxycinnamate loaded microemulsion by molecular fluorescence and chemometric approach

    Science.gov (United States)

    Nascimento, Danielle Silva; Insausti, Matías; Band, Beatriz Susana Fernández; Grünhut, Marcos

    2018-02-01

    Octyl p-methoxycinnamate (OMC) is one of the most widely used sunscreen agents. However, the efficiency of OMC as UV filter over time is affected due to the formation of the cis-isomer which presents a markedly lower extinction coefficient (εcis = 12,600 L mol- 1 cm- 1 at 291 nm) than the original trans-isomer (εtrans = 24,000 L mol- 1 cm- 1 at 310 nm). In this work, a novel carrier for OMC based on an oil-in-water microemulsion is proposed in order to improve the photostability of this sunscreen. The formulation was composed of 29.2% (w/w) of a 3:1 mixture of ethanol (co-surfactant) and decaethylene glycol mono-dodecyl ether (surfactant), 1.5% (w/w) of oleic acid (oil phase) and 69.2% (w/w) of water. This microemulsion was prepared in a simple way, under moderate stirring at 25 °C and using acceptable, biocompatible and accessible materials for topical use. OMC was incorporated in the vehicle at a final concentration of 5.0% (w/w), taking into account the maximum permitted levels established by international norms. Then, a photolysis study of the loaded formulation was performed using a continuous flow system. The direct photolysis was monitored over time by molecular fluorescence. The recorded spectra data between 370 y 490 nm were analyzed by multivariate curve resolution-alternating least squares algorithm. The kinetic rate constants corresponding to the photolysis of the trans-OMC were calculated from the concentration profiles, resulting in 0.0049 s- 1 for the trans-OMC loaded microemulsion and 0.0131 s- 1 for the trans-OMC in aqueous media. These results demonstrate a higher photostability of the trans-OMC when loaded in the proposed vehicle with respect to the free trans-OMC in aqueous media.

  8. Study of nitric oxide catalytic oxidation on manganese oxides-loaded activated carbon at low temperature

    Energy Technology Data Exchange (ETDEWEB)

    You, Fu-Tian [Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen (China); University of Chinese Academy of Sciences, Beijing (China); Yu, Guang-Wei, E-mail: gwyu@iue.ac.cn [Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen (China); Wang, Yin, E-mail: yinwang@iue.ac.cn [Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen (China); Xing, Zhen-Jiao [Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen (China); Liu, Xue-Jiao; Li, Jie [Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen (China); University of Chinese Academy of Sciences, Beijing (China)

    2017-08-15

    Highlights: • Loading manganese oxides on activated carbon effectively promotes NO oxidation. • NO adsorption-desorption on activated carbon is fundamental to NO oxidation. • A high Mn{sup 4+}/Mn{sup 3+} ratio contributes to NO oxidation by promoting lattice O transfer. - Abstract: Nitric oxide (NO) is an air pollutant that is difficult to remove at low concentration and low temperature. Manganese oxides (MnO{sub x})-loaded activated carbon (MLAC) was prepared by a co-precipitation method and studied as a new catalyst for NO oxidation at low temperature. Characterization of MLAC included X-ray diffraction (XRD), scanning electron microscopy (SEM), N{sub 2} adsorption/desorption and X-ray photoelectron spectroscopy (XPS). Activity tests demonstrated the influence of the amount of MnO{sub x} and the test conditions on the reaction. MLAC with 7.5 wt.% MnO{sub x} (MLAC003) exhibits the highest NO conversion (38.7%) at 1000 ppm NO, 20 vol.% O{sub 2}, room temperature and GHSV ca. 16000 h{sup −1}. The NO conversion of MLAC003 was elevated by 26% compared with that of activated carbon. The results of the MLAC003 activity test under different test conditions demonstrated that NO conversion is also influenced by inlet NO concentration, inlet O{sub 2} concentration, reaction temperature and GHSV. The NO adsorption-desorption process in micropores of activated carbon is fundamental to NO oxidation, which can be controlled by pore structure and reaction temperature. The activity elevation caused by MnO{sub x} loading is assumed to be related to Mn{sup 4+}/Mn{sup 3+} ratio. Finally, a mechanism of NO catalytic oxidation on MLAC based on NO adsorption-desorption and MnO{sub x} lattice O transfer is proposed.

  9. Formulation, physicochemical characterization and stability study of lithium-loaded microemulsion system.

    Science.gov (United States)

    Mouri, Abdelkader; Legrand, Philippe; El Ghzaoui, Abdeslam; Dorandeu, Christophe; Maurel, Jean Claude; Devoisselle, Jean-Marie

    2016-04-11

    Lithium biocompatible microemulsion based on Peceol(®), lecithin, ethanol and water was studied in attempt to identify the optimal compositions in term of drug content, physicochemical properties and stability. Lithium solubilization in microemulsion was found to be compatible with a drug-surfactant binding model. Lithium ions were predominantly solubilized within lecithin head group altering significantly the interfacial properties of the system. Pseudo-ternary phase diagrams of drug free and drug loaded microemulsions were built at constant ethanol/lecithin weight ratio (40/60). Lithium loaded microemulsion has totally disappeared in the Peceol(®) rich part of phase diagram; critical fractions of lecithin and ethanol were required for the formation of stable microemulsion. The effect of lithium concentration on the properties and physical stability of microemulsions were studied using microscopy, Karl Fischer titrations, rheology analyses, conductivity measurements and centrifugation tests. The investigated microemulsions were found to be stable under accelerated storage conditions. The systems exhibited low viscosity and behaved as Newtonian fluid and no structural transition was shown. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Studying the loading effect of acidic type antioxidant on amorphous silica nanoparticle carriers

    Science.gov (United States)

    Ravinayagam, Vijaya; Rabindran Jermy, B.

    2017-06-01

    The study investigates the suitable nanosilica carriers to transport acidic type cargo molecules for potential targeted drug delivery application. Using phenolic acidic type antioxidant gallic acid (GA) as model compound, the present study investigates the loading effect of GA (0.3-15.9 mmol GA g-1 support) on textural characteristics of amorphous silica nanoparticles such as Q10 silica (1D), structured two-dimensional Si-MCM-41 (2D), and three-dimensional Si-SBA-16 (3D). The variation in the nature of textures after GA loading was analyzed using X-ray diffraction, N2 adsorption, FT-IR, scanning electron microscopy with energy dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy. Among the nanocarriers, high adsorption of GA was found in the following order: Si-SBA-16 (3D)˜Si-KIT-6 (3D) > Si-MCM-41 (2D) > ultralarge pore FDU-12 (ULPFDU-12; 3D) > Q10 (1D)˜mesostructured cellular silica foam (MSU-F). 3D-type silicas Si-SBA-16 and KIT-6 were shown to maintain structural integrity at acidic condition (pH ˜3) and accommodate GA in non-crystalline form. In the case of ULPFDU-12 and MSU-F cellular foam, only crystalline deposition of GA occurs with a significant variation in the surface area and pore volume. [Figure not available: see fulltext.

  11. Influence of foundation settlements in load redistribution on columns in a monitoring construction - Case Study

    Directory of Open Access Journals (Sweden)

    G. Savaris

    Full Text Available The objective of this article is to present the results obtained in a study on the interaction between the behavior of the structure and the foundation settlements and verify the influence of normal load distribution on the columns. In this mechanism, known as structure soil interaction (SSI, as the building is constructed, a transfer of loads occurs from the columns which tend to settle more to those that tend to settle less. The study was conducted in a building which had its settlements monitored from the beginning of construction. For this purpose, a linear tridimensional numerical model was constructed and numerical analysis was performed, using the finite elements method. In these analyses, numerical models corre- sponding to the execution of each floor were used, considering the settlements measured in each stage of the construction. The results of analy- ses showed that the effect of SSI are significant for calculating the normal efforts on the columns, particularly on those located in the first floors.

  12. Study on Repaired Earthquake-Damaged Bridge Piers under Seismic Load

    Directory of Open Access Journals (Sweden)

    Jun Deng

    2015-01-01

    Full Text Available The concrete bridge pier damaged during earthquakes need be repaired to meet the design standards. Steel tube as a traditional material or FRP as a novel material has become popular to repair the damaged reinforced concrete (RC bridge piers. In this paper, experimental and finite element (FE studies are employed to analyze the confinement effectiveness of the different repair materials. The FE method was used to calculate the hysteretic behavior of three predamaged circle RC bridge piers repaired with steel tube, basalt fiber reinforced polymer (BFRP, and carbon fiber reinforced polymer (CFRP, respectively. Meanwhile, the repaired predamaged circle concrete bridge piers were tested by pseudo-static cyclic loading to study the seismic behavior and evaluate the confinement effectiveness of the different repair materials and techniques. The FE analysis and experimental results showed that the repaired piers had similar hysteretic curves with the original specimens and all the three repair techniques can restore the seismic performance of the earthquake-damaged piers. Steel tube jacketing can significantly improve the lateral stiffness and peak load of the damaged pier, while the BFRP and CFRP sheets cannot improve these properties due to their thin thickness.

  13. A study on the stress history condensation method for a fatigue monitoring system

    International Nuclear Information System (INIS)

    Ko, Hanok; Jhung, Myungjo; Lee, Kihyoung

    2014-01-01

    Fatigue damage is the one of important aging mechanisms. Time-varying thermal, pressure and mechanical loads produce perturbations of stress cycles primarily at the surface of a component. Stress cycles of sufficient magnitude cause fatigue damage, which can ultimately lead to cracking of the component. According to NUREG-1801, fatigue monitoring systems identify acceptable aging management programs, including programs for fatigue and cyclic operation. In a monitoring system, the rainflow counting method is mainly used as the stress cycle counting method. Before determining the stress cycles using rainflow counting method, stress extremum (or peak/valley) must be identified. Because real stress history contains large numbers of very small cycles, which may be a result of digitization noise, these cycles will slow down the analysis and distort the scaling of graphical displays. As a result, it is found that stress cycles smaller than a threshold value are discarded by using the proposed method. In this paper, an engineering methodology which extracts extremum from the real-time transient data, so-called SEE, has been developed. The proposed method is very simple and so fast because it only uses the difference between the input value and local peak/valley. The stress cycles counted by two methods are compared with those counted by only rainflow counting method and it is found that stress cycles smaller than a threshold value were eliminated

  14. Remaining life case history studies for high energy piping systems using equivalent stress

    International Nuclear Information System (INIS)

    Cohn, M.J.

    1987-01-01

    As the development of plant life extension for high energy piping systems is progressing, conventional piping system design methodologies are also being reevaluated. Traditional guidelines such as American National Standard Institute/American Society of Mechanical Engineers B31.1 (ANSI/ASME) were developed for plants having design lives in the 25- to 30-year regime based upon relatively short-term base metal creep data. These guidelines use a simplified approach for the piping analysis. Two types of stress criteria must be satisfied. The first type is longitudinal plus torsion stress checks for several types of loading conditions versus the material allowable stresses. The second type is an independent minimum wall thickness check which considers the hoop stress versus the material allowable stress. Seven case histories have been evaluated to estimate the minimum piping system creep life based on the current ANSI/ASME B31.1 finite element type of analysis, which is a traditional approach, versus a multiaxial stress state type of analysis. In nearly every case, the equivalent stress methodology predicted significantly higher stresses. Consequently, the equivalent stress methodology resulted in 11 to 96% lower time to rupture values as compared to the values predicted using ANSI/ASME B31.1 stresses

  15. Theoretical study of the electromechanical efficiency of a loaded tubular dielectric elastomer actuator

    DEFF Research Database (Denmark)

    Rechenbach, Björn; Willatzen, Morten; Lassen, Benny

    2016-01-01

    The electromechanical efficiency of a loaded tubular dielectric elastomer actuator (DEA) is investigated theoretically. In previous studies, the external system, on which the DEA performs mechanical work, is implemented implicitly by prescribing the stroke of the DEA in a closed operation cycle....... Here, a more generic approach, modelling the external system by a frequency-dependent mechanical impedance which exerts a certain force on the DEA depending on its deformation, is chosen. It admits studying the dependence of the electromechanical efficiency of the DEA on the external system. A closed...... operation cycle is realized by exciting the DEA electrically by a sinusoidal voltage around a bias voltage. A detailed parametric study shows that the electromechanical efficiency is highly dependent on the frequency, amplitude, and bias of the excitation voltage and the mechanical impedance of the external...

  16. Pupil Perspectives on the Purposes and Benefits of Studying History in High School: A View from the UK

    Science.gov (United States)

    Haydn, Terry; Harris, Richard

    2010-01-01

    Drawing on data from 1740 pupil questionnaires and 160 pupils in focus-group interviews, the study aimed to gain insight into British pupils' ideas about why they study history at school. The paper considers the implications of these ideas for history teachers and teacher educators. The data suggest that many pupils have very vague ideas about the…

  17. Seasonal Variations and Yearly Trend Evaluations of Sedimentation Loads: A Case Study at Chalok River, Terengganu, Malaysia

    Directory of Open Access Journals (Sweden)

    Aida Soraya Shamsuddin

    2014-01-01

    Full Text Available The aims of this study were to determine the relationship between seasonal variations (wet and dry periods on sedimentation loads and to identify the yearly trend of sedimentation loads at Chalok River, Terengganu, Malaysia from 2003 to 2008. It was found that wet and dry periods influenced the transportation of suspended sediment into the river significantly. The highest suspended sediment loads at Chalok River occurred during the wet period when the intensity of rainfall is high. Besides, the rainfall, water level, stream flow and suspended sediment loads also were analysed using Spearman correlation to identify their relationships. The results showed significant positive relationship between suspended sediment loads with rainfall (r = 0.664, p< 0.05, water level (r = 0.923, p< 0.05 and stream flow (r = 0.919, p< 0.05. Multiple linear regressions revealed 63% of high suspended sediment loads at Chalok River can be explained by rainfall, water level and stream flow. The trends of rainfall, water level, stream flow and suspended sediment loads were analysed by using Mann-Kendall trend test where the results showed that there is a significant increasing trend for suspended sediment loads but no significant increase trend for rainfall, water level and stream flow over the studied periods. It is evident that the evaluations conducted in this study are useful in providing better understanding and reliable conclusion on the basis of seasonal variations and other environmental variables that affect the sedimentations loads in the river. Such effort provides holistic information for effective and wise management policy of river basin management in the future.

  18. Comparative study between clinical history and polysomnogram in the obstructive sleep apnea/ hypopnea syndrome.

    Science.gov (United States)

    Gondim, Lys Maria Allenstein; Matumoto, Luciana Matshie; Melo Júnior, Marco Antônio Cezário de; Bittencourt, Sérgio; Ribeiro, Ulisses José

    2007-01-01

    Recognizing sleep-disordered breathing is on the rise every year. Manifestations, such as snoring, that were earlier considered mere inconvenients are now acquiring greater importance concerning life quality and social impact. To compare the clinical history to polysomnogram (PSG) results in the Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS). 125 patients were analyzed, in a retrospective study. Specific questionnaires, avaliations of Body Mass Index and Epworth Scale were carried out. Among the patients, 75 were males and 50 were females. The main symptom was snoring. 46% had normal PSG, 30% had light OSAHS, 15% moderate and 9% severe OSAHS and it was not observed a correlation between clinical data and PSG results. Concerning clinical symptoms, only insomnia has shown relevance when univariably analyzed in normal and light OSAHS patients (plosing its importance when analyzed together with other factors. the clinical history, per se, is not sufficient to define OSAHS' diagnosis or it's severity.

  19. Teaching Recent History in Countries that Have Experienced Human Rights Violations: Case Studies from Chile

    Science.gov (United States)

    Toledo, Maria Isabel; Magendzo, Abraham; Gazmuri, Renato

    2011-01-01

    Incorporating recent history into the educational curricula of countries that have experienced human rights violations combines the complexities of teaching history, teaching recent history, and human rights education. Recent history makes a historical analysis of social reality and a historiographical analysis of the immediate. It is located…

  20. Study of load change control in PWRs using the methods of linear optimal control

    International Nuclear Information System (INIS)

    Yang, T.

    1983-01-01

    This thesis investigates the application of modern control theory to the problem of controlling load changes in PWR power plants. A linear optimal state feedback scheme resulting from linear optimal control theory with a quadratic cost function is reduced to a partially decentralized control system using mode preservation techniques. Minimum information transfer among major components of the plant is investigated to provide an adequate coordination, simple implementation, and a reliable control system. Two control approaches are proposed: servo and model following. Each design considers several information structures for performance comparison. Integrated output error has been included in the control systems to accommodate external and plant parameter disturbances. In addition, the cross limit feature, specific to certain modern reactor control systems, is considered in the study to prevent low pressure reactor trip conditions. An 11th order nonlinear model for the reactor and boiler is derived based on theoretical principles, and simulation tests are performed for 10% load change as an illustration of system performance

  1. Loading of praziquantel in the crystal lattice of solid lipid nanoparticles - studies by DSC and SAXS

    Energy Technology Data Exchange (ETDEWEB)

    Souza, A.L.R.; Cassimiro, D.L.; Almeida, A.E.; Ribeiro, C.A.; Gremiao, M.P.D. [UNESP, Araraquara, SP (Brazil); Sarmento, V.H.V. [Universidade Federal de Sergipe (UFS), Itabaiana, SE (Brazil); Andreani, T.; Silva, A.M.; Souto, E.B. [Universidade de Tras-os-Montes e Alto Douro, Vila Real (Portugal)

    2012-07-01

    Full text: Praziquantel (PZQ) is the drug of choice for oral treatment of schistosomiasis and other fluke infections that affect humans. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. In this work, solid lipid nanoparticles loaded with PZQ (PZQ-SLN) were prepared by a modified oil-in-water microemulsion method selecting stearic acid as lipid phase after solubility screening studies. The mean particle size (Z-Ave) and zeta potential (ZP) were 500 nm and -34.0 mV, respectively. Morphology and shape of PZQ-SLN were analysed by scanning electron microscopy revealing the presence of spherical particles with smooth surface. Differential scanning calorimetry suggested that SLN comprised a less ordered arrangement of crystals and the drug was molecularly dispersed in the lipid matrix. No supercooled melts were detected. The entrapment efficiency (EE) and loading capacity of PZQ, determined by high performance liquid chromatography, were 99.0 and 17.5, respectively. Effective incorporation of PZQ into the particles was confirmed by small angle X-ray scattering revealing the presence of a lipid lamellar structure. Stability parameters of PZQ-SLN stored at room temperature (25 deg C) and at 4 deg C were checked by analysing Z-Ave, ZP and the EE for a period of 60 days Results showed a relatively long-term physical stability after storage at 4 deg C, without drug expulsion. (author)

  2. An experimental study on pile spacing effects under lateral loading in sand.

    Science.gov (United States)

    Khari, Mahdy; Kassim, Khairul Anuar; Adnan, Azlan

    2013-01-01

    Grouped and single pile behavior differs owing to the impacts of the pile-to-pile interaction. Ultimate lateral resistance and lateral subgrade modulus within a pile group are known as the key parameters in the soil-pile interaction phenomenon. In this study, a series of experimental investigation was carried out on single and group pile subjected to monotonic lateral loadings. Experimental investigations were conducted on twelve model pile groups of configurations 1 × 2, 1 × 3, 2 × 2, 3 × 3, and 3 × 2 for embedded length-to-diameter ratio l/d = 32 into loose and dense sand, spacing from 3 to 6 pile diameter, in parallel and series arrangement. The tests were performed in dry sand from Johor Bahru, Malaysia. To reconstruct the sand samples, the new designed apparatus, Mobile Pluviator, was adopted. The ultimate lateral load is increased 53% in increasing of s/d from 3 to 6 owing to effects of sand relative density. An increasing of the number of piles in-group decreases the group efficiency owing to the increasing of overlapped stress zones and active wedges. A ratio of s/d more than 6d is large enough to eliminate the pile-to-pile interaction and the group effects. It may be more in the loose sand.

  3. Rock Fracture Toughness Study Under Mixed Mode I/III Loading

    Science.gov (United States)

    Aliha, M. R. M.; Bahmani, A.

    2017-07-01

    Fracture growth in underground rock structures occurs under complex stress states, which typically include the in- and out-of-plane sliding deformation of jointed rock masses before catastrophic failure. However, the lack of a comprehensive theoretical and experimental fracture toughness study for rocks under contributions of out-of plane deformations (i.e. mode III) is one of the shortcomings of this field. Therefore, in this research the mixed mode I/III fracture toughness of a typical rock material is investigated experimentally by means of a novel cracked disc specimen subjected to bend loading. It was shown that the specimen can provide full combinations of modes I and III and consequently a complete set of mixed mode I/III fracture toughness data were determined for the tested marble rock. By moving from pure mode I towards pure mode III, fracture load was increased; however, the corresponding fracture toughness value became smaller. The obtained experimental fracture toughness results were finally predicted using theoretical and empirical fracture models.

  4. Loading of praziquantel in the crystal lattice of solid lipid nanoparticles - studies by DSC and SAXS

    International Nuclear Information System (INIS)

    Souza, A.L.R.; Cassimiro, D.L.; Almeida, A.E.; Ribeiro, C.A.; Gremiao, M.P.D.; Sarmento, V.H.V.; Andreani, T.; Silva, A.M.; Souto, E.B.

    2012-01-01

    Full text: Praziquantel (PZQ) is the drug of choice for oral treatment of schistosomiasis and other fluke infections that affect humans. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. In this work, solid lipid nanoparticles loaded with PZQ (PZQ-SLN) were prepared by a modified oil-in-water microemulsion method selecting stearic acid as lipid phase after solubility screening studies. The mean particle size (Z-Ave) and zeta potential (ZP) were 500 nm and -34.0 mV, respectively. Morphology and shape of PZQ-SLN were analysed by scanning electron microscopy revealing the presence of spherical particles with smooth surface. Differential scanning calorimetry suggested that SLN comprised a less ordered arrangement of crystals and the drug was molecularly dispersed in the lipid matrix. No supercooled melts were detected. The entrapment efficiency (EE) and loading capacity of PZQ, determined by high performance liquid chromatography, were 99.0 and 17.5, respectively. Effective incorporation of PZQ into the particles was confirmed by small angle X-ray scattering revealing the presence of a lipid lamellar structure. Stability parameters of PZQ-SLN stored at room temperature (25 deg C) and at 4 deg C were checked by analysing Z-Ave, ZP and the EE for a period of 60 days Results showed a relatively long-term physical stability after storage at 4 deg C, without drug expulsion. (author)

  5. The studies of PLGA nanoparticles loading atorvastatin calcium for oral administration in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Zhenbao Li

    2017-05-01

    Full Text Available A biodegradable poly(lactic-co-glycolic acid loading atorvastatin calcium (AC nanoparticles (AC-PLGA-NPs were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental parameters, including stabilizer species, stabilizer concentration and pH of aqueous phase, on particle size were also evaluated. The resultant nanoparticles were in spherical shape with an average diameter of 174.7 nm and a narrow particle size distribution. And the drug loading and encapsulation efficiency were about 8% and 71%, respectively. The particle size and polydispersion were almost unchanged in 10 days. The release curves of AC-PLGA-NPs in vitro displaying sustained release characteristics indicated that its release mechanisms were matrix erosion and diffusion. The pharmacokinetic study in vivo revealed that the Cmax and AUC0-∞ of AC-PLGA-NPs in rats were nearly 3.7-fold and 4.7-fold higher than that of pure atorvastatin calcium suspension. Our results demonstrated that the delivery of AC-PLGA-NPs could be a promising approach for the oral delivery of AC for enhanced bioavailability.

  6. Numerical study of radial stepwise fuel load reshuffling traveling wave reactor

    International Nuclear Information System (INIS)

    Zhang Dalin; Zheng Meiyin; Tian Wenxi; Qiu Suizheng; Su Guanghui

    2015-01-01

    Traveling wave reactor is a new conceptual fast breeder reactor, which can adopt natural uranium, depleted uranium and thorium directly to realize the self sustainable breeding and burning to achieve very high fuel utilization fraction. Based on the mechanism of traveling wave reactor, a concept of radial stepwise fuel load reshuffling traveling wave reactor was proposed for realistic application. It was combined with the typical design of sodium-cooled fast reactors, with which the asymptotic characteristics of the inwards stepwise fuel load reshuffling were studied numerically in two-dimension. The calculated results show that the asymptotic k_e_f_f parabolically varies with the reshuffling cycle length, while the burnup increases linearly. The highest burnup satisfying the reactor critical condition is 38%. The power peak shifts from the fuel discharging zone (core centre) to the fuel uploading zone (core periphery) and correspondingly the power peaking factor decreases along with the reshuffling cycle length. In addition, at the high burnup case the axial power distribution close to the core centre displays the M-shaped deformation. (authors)

  7. An Experimental Study on Pile Spacing Effects under Lateral Loading in Sand

    Science.gov (United States)

    Khari, Mahdy; Kassim, Khairul Anuar; Adnan, Azlan

    2013-01-01

    Grouped and single pile behavior differs owing to the impacts of the pile-to-pile interaction. Ultimate lateral resistance and lateral subgrade modulus within a pile group are known as the key parameters in the soil-pile interaction phenomenon. In this study, a series of experimental investigation was carried out on single and group pile subjected to monotonic lateral loadings. Experimental investigations were conducted on twelve model pile groups of configurations 1 × 2, 1 × 3, 2 × 2, 3 × 3, and 3 × 2 for embedded length-to-diameter ratio l/d = 32 into loose and dense sand, spacing from 3 to 6 pile diameter, in parallel and series arrangement. The tests were performed in dry sand from Johor Bahru, Malaysia. To reconstruct the sand samples, the new designed apparatus, Mobile Pluviator, was adopted. The ultimate lateral load is increased 53% in increasing of s/d from 3 to 6 owing to effects of sand relative density. An increasing of the number of piles in-group decreases the group efficiency owing to the increasing of overlapped stress zones and active wedges. A ratio of s/d more than 6d is large enough to eliminate the pile-to-pile interaction and the group effects. It may be more in the loose sand. PMID:24453900

  8. Wind-induced transmission tower foundation loads. A field study-design code comparison

    Energy Technology Data Exchange (ETDEWEB)

    Savory, E. [Department of Mechanical and Materials Engineering, University of Western Ontario, London, Ont. (Canada); Parke, G.A.R.; Disney, P.; Toy, N. [School of Engineering, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom)

    2008-06-15

    This paper presents a comparison between the wind-induced foundation loads measured on a type L6 transmission line tower during a field study in the UK and those computed using the UK Code of Practice for lattice tower and transmission line design (BS8100). In this work, the Code provisions have been generalised to give the wind-induced strain in each of the tower legs immediately above the foundation as a function of wind direction and wind speed at the top of the tower. The complete data set from the field monitoring has been decomposed to provide a similar formulation for comparison purposes. The analysis shows excellent agreement between the Code calculations and the measured results, within the overall accuracy of the field data. This indicates that, at least for the tower type examined here, the existing design Code provides a reliable transformation of the local wind speed at the top of the tower into tension and compression loads on the foundations. (author)

  9. Immediate loading implants with mandibular overdenture: a 48-month prospective follow-up study

    Directory of Open Access Journals (Sweden)

    Karla ZANCOPE

    2014-08-01

    Full Text Available The aim of this prospective clinical study was to evaluate patient rehabilitation with two immediately loaded implants and bar-retained mandibular overdentures after 48 months of follow-up. Twenty patients were treated with two implants each; of these, 17 patients were re-evaluated for comparison. Gender, age, plaque index, gingival inflammation, keratinized mucosa, probing depth, bleeding, and implant loss data were recorded, and periapical radiographs were obtained for measurement of marginal bone loss. The results were statistically analyzed with one-way analysis of variance (ANOVA followed by Student’s t-test and Pearson’s correlation test. To compare the data at baseline and after 48 months, a Wilcoxon Signed Rank Test was performed (α = 0.05. One implant failed (2.9% during the first year and was replaced. A total of 35 implants were evaluated. Bone loss values were 0.52–2.89 mm (mean, 1.46 mm. Probing depth was 1.75–3.75 mm (mean, 2.22 mm. Correlations were found between bone loss and plaque index and between bone loss and gender, but bone loss did not correlate with gingival inflammation, keratinized mucosa, probing depth, or age. The overall survival rate of the implants was 97.1%. Based on these results, the use of two immediately loaded splinted interforaminal implants to retain an overdenture with a bar attachment is a clinically viable option with a high survival rate.

  10. Neuropathic pain in the orofacial region: The role of pain history. A retrospective study.

    Science.gov (United States)

    Dieb, W; Moreau, N; Chemla, I; Descroix, V; Boucher, Y

    2017-06-01

    Orofacial neuropathic pain is often difficult to treat, mostly because of still unclear underlying mechanisms. The occurrence of such neuropathic pain varies depending on different factors, of which preexisting preoperative pain seems to be of high importance. The aim of this study was thus to test the hypothesis that prior history of pain could indeed be considered a risk factor for the development of orofacial neuropathic pain in the same region. The study was performed in the dental department of the Groupe Hospitalier Pitié-Salpêtrière (GHPS) in Paris, France. We investigated the presence of prior inflammatory pain before development of orofacial neuropathic pain in 56 patients. For each patient file, the following items were collected: age, gender; medical history; diagnosis; description of the pain (at time of consultation); presence or absence of prior dental treatment; date and type of dental treatment received. 41 patients (73%) of orofacial neuropathic pain patients had a history of pain compatible with an inflammatory condition; 4% (n=2) did not report any prior pain and 23% (n=13) could not remember. Among the patients with documented history of pain prior to neuropathy, 88% (n=36) received surgical treatment; 61%, (n=25) endodontic treatment and 22%, (n=9) restorative treatment. All eventually received endodontic treatment or tooth extraction. These dental treatments are compatible with the hypothesis of prior inflammatory pain in these patients. These results support the hypothesis that prior inflammatory pain could favor the development of orofacial neuropathic pain. Prevention and treatment of inflammatory trigeminal pain may therefore play a key role in preventing future neuropathic pain development. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  11. Cumulative occupational lumbar load and lumbar disc disease – results of a German multi-center case-control study (EPILIFT

    Directory of Open Access Journals (Sweden)

    Michaelis Martina

    2009-05-01

    Full Text Available Abstract Background The to date evidence for a dose-response relationship between physical workload and the development of lumbar disc diseases is limited. We therefore investigated the possible etiologic relevance of cumulative occupational lumbar load to lumbar disc diseases in a multi-center case-control study. Methods In four study regions in Germany (Frankfurt/Main, Freiburg, Halle/Saale, Regensburg, patients seeking medical care for pain associated with clinically and radiologically verified lumbar disc herniation (286 males, 278 females or symptomatic lumbar disc narrowing (145 males, 206 females were prospectively recruited. Population control subjects (453 males and 448 females were drawn from the regional population registers. Cases and control subjects were between 25 and 70 years of age. In a structured personal interview, a complete occupational history was elicited to identify subjects with certain minimum workloads. On the basis of job task-specific supplementary surveys performed by technical experts, the situational lumbar load represented by the compressive force at the lumbosacral disc was determined via biomechanical model calculations for any working situation with object handling and load-intensive postures during the total working life. For this analysis, all manual handling of objects of about 5 kilograms or more and postures with trunk inclination of 20 degrees or more are included in the calculation of cumulative lumbar load. Confounder selection was based on biologic plausibility and on the change-in-estimate criterion. Odds ratios (OR and 95% confidence intervals (CI were calculated separately for men and women using unconditional logistic regression analysis, adjusted for age, region, and unemployment as major life event (in males or psychosocial strain at work (in females, respectively. To further elucidate the contribution of past physical workload to the development of lumbar disc diseases, we performed lag

  12. Study of the energy gain and the beam loading of the detuned structure with a simple model

    International Nuclear Information System (INIS)

    Heifets, S.A.; Kheifets, S.A.

    1993-01-01

    A circuit model for the longitudinal case from which to study the field pattern, energy gain and beam loading of a detuned structure is derived from Maxwell's equations. The results obtained with the model are compared to numerical results of the code PROGON. The model gives reasonable scaling of the group velocity and voltage with geometric parameters. The energy gain and beam loading are compared and are shown to depend on the same factor. This is true even for periodic variations of the boundary. Finally, a way to find the shape of the rf pulse envelope for the beam loading compensation is suggested

  13. Polymeric films loaded with cisplatin for malignant pleural mesothelioma: a pharmacokinetic study in an ovine model

    Science.gov (United States)

    Barocelli, Elisabetta; Cavazzoni, Andrea; Petronini, Piergiorgio; Mucchino, Claudio; Cantoni, Anna Maria; Leonardi, Fabio; Ventura, Luigi; Barbieri, Stefano; Colombo, Paolo; Fusari, Antonella; Carbognani, Paolo; Rusca, Michele; Sonvico, Fabio

    2018-01-01

    Background Malignant pleural mesothelioma (MPM) continues to be a distressing tumor due to its aggressive biologic behavior and scanty prognosis. Several therapeutic approaches have been tested both in clinical and preclinical settings, being intrapleural chemotherapy one of the most promising. Some years ago, our interest focused on polymeric films loaded with cisplatin for the adjuvant intrapleural treatment of surgical patients. After in vitro and in vivo studies in a rat recurrence model of MPM, the aim of this study was to evaluate the pharmacokinetics of the polymeric films in a sheep model in view of further studies in a clinical setting. Methods An ovine model was used. Animals were divided into four groups according to pharmacologic treatment: control group (three animals undergoing left pneumonectomy and saline-NaCl solution); intrapleural hyaluronate cisplatin films (HYALCIS) group (six animals undergoing left pneumonectomy and intrapleural application of polymeric films loaded with cisplatin); intrapleural cisplatin solution (six animals undergoing left pneumonectomy and intrapleural application of cisplatin solution); intravenous cisplatin (five animals undergoing left pneumonectomy and intravenous administration of cisplatin solution). The primary objective was the plasmatic and pleural concentration of cisplatin in the treatment groups. The secondary objective was the treatment-related toxicity evaluated by plasmatic analysis performed at prearranged time intervals and histological examinations of tissue samples collected during animal autopsy. Analysis of variance (ANOVA) was used for statistical analysis. Bonferroni correction was applied for comparison between all groups. Results Twenty female Sardinian sheep with a mean weight of 45.1 kg were studied. All animals survived the surgical procedures. The whole surgical procedure had a mean duration of 113 minutes. Cisplatin blood levels obtained from polymeric films application were low during the

  14. A numerical study of crack interactions under thermo-mechanical load using EFGM

    International Nuclear Information System (INIS)

    Pant, Mohit; Singh, I. V.; Mishra, B. K.

    2011-01-01

    In this work, element free Galerkin method (EFGM) has been used to obtain the solution of various edge crack problems under thermo-mechanical loads as it provides a versatile technique to model stationary as well as moving crack problems without re-meshing. Standard diffraction criterion has been modified with multiple crack weight technique to characterize the presence of various cracks in the domain of influence of a particular node. The effect of crack inclination has been studied for single as well as two edge cracks, whereas the cracks interaction has been studied for two edge cracks lying on same as well as opposite edges under plane stress conditions. The values of mode-I and mode-II stress intensity factors have been evaluated by the interaction integral approach

  15. Optimality study of a gust alleviation system for light wing-loading STOL aircraft

    Science.gov (United States)

    Komoda, M.

    1976-01-01

    An analytical study was made of an optimal gust alleviation system that employs a vertical gust sensor mounted forward of an aircraft's center of gravity. Frequency domain optimization techniques were employed to synthesize the optimal filters that process the corrective signals to the flaps and elevator actuators. Special attention was given to evaluating the effectiveness of lead time, that is, the time by which relative wind sensor information should lead the actual encounter of the gust. The resulting filter is expressed as an implicit function of the prescribed control cost. A numerical example for a light wing loading STOL aircraft is included in which the optimal trade-off between performance and control cost is systematically studied.

  16. Thermal buckling behavior of defective CNTs under pre-load: A molecular dynamics study.

    Science.gov (United States)

    Mehralian, Fahimeh; Tadi Beni, Yaghoub; Kiani, Yaser

    2017-05-01

    Current study is concentrated on the extraordinary properties of defective carbon nanotubes (CNTs). The role of vacancy defects in thermal buckling response of precompressed CNTs is explored via molecular dynamics (MD) simulations. Defective CNTs are initially compressed at a certain ratio of their critical buckling strain and then undergo a uniform temperature rise. Comprehensive study is implemented on both armchair and zigzag CNTs with different vacancy defects including monovacancy, symmetric bivacancy and asymmetric bivacancy. The results reveal that defects have a pronounced impact on the buckling behavior of CNTs; interestingly, defective CNTs under compressive pre-load show higher resistance to thermal buckling than pristine ones. In the following, the buckling response of defective CNTs is shown to be dependent on the vacancy defects, location of defects and chirality. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. A Study of Cognitive Load for Enhancing Student’s Quantitative Literacy in Inquiry Lab Learning

    Science.gov (United States)

    Nuraeni, E.; Rahman, T.; Alifiani, D. P.; Khoerunnisa, R. S.

    2017-09-01

    Students often find it difficult to appreciate the relevance of the role of quantitative analysis and concept attainment in the science class. This study measured student cognitive load during the inquiry lab of the respiratory system to improve quantitative literacy. Participants in this study were 40 11th graders from senior high school in Indonesia. After students learned, their feelings about the degree of mental effort that it took to complete the learning tasks were measured by 28 self-report on a 4-point Likert scale. The Task Complexity Worksheet were used to asses processing quantitative information and paper based test were applied to assess participants’ concept achievements. The results showed that inquiry instructional induced a relatively low mental effort, high processing information and high concept achievments.

  18. Tamoxifen-loaded polymeric micelles: preparation, physico-chemical characterization and in vitro evaluation studies.

    Science.gov (United States)

    Cavallaro, Gennara; Maniscalco, Laura; Licciardi, Mariano; Giammona, Gaetano

    2004-11-20

    Several samples of polymeric micelles, formed by amphiphilic derivatives of PHEA, obtained by grafting into polymeric backbone of PEGs and/or hexadecylamine groups (PHEA-PEG-C(16) and PHEA-C(16)) and containing different amount of Tamoxifen, were prepared. All Tamoxifen-loaded polymeric micelles showed to increase drug water solubility. TEM studies provided evidence of the formation of supramolecular core/shell architectures containing drug, in the nanoscopic range and with spherical shape. Samples with different amount of encapsulated Tamoxifen were subjected to in vitro cytotoxic studies in order to evaluate the effect of Tamoxifen micellization on cell growth inhibition. All samples of Tamoxifen-loaded polymeric micelles showed a significantly higher antiproliferative activity in comparison with free drug, probably attributable to fluidification of cellular membranes, caused by amphiphilic copolymers, that allows a higher penetration of the drug into tumoral cells. To gain preliminary information about the potential use of prepared micelles as Tamoxifen drug delivery systems, studies evaluating drug release ability of micelle systems in media mimicking biological fluids (buffer solutions at pH 7.4 and 5.5) and in human plasma were carried out. These studies, performed evaluating the amount of Tamoxifen that remains in solution as a function of time, showed that at pH 7.4, as well as in plasma, PHEA-C(16) polymeric micelles were able to release lower drug amounts than PHEA-PEG(5000)-C(16) ones, while at pH 5.5, the behavior difference between two kind of micelles was less pronounced.

  19. Relaxation of Shot-Peened Residual Stresses Under Creep Loading (Preprint)

    National Research Council Canada - National Science Library

    Buchanan, Dennis J; John, Reji; Brockman, Robert A

    2008-01-01

    .... Compressive residual stresses retard initiation and growth of fatigue cracks. During the component loading history, loading, or during elevated temperature static loading, such as thermal exposure and creep...

  20. Study on loading coefficient in steam explosion process of corn stalk.

    Science.gov (United States)

    Sui, Wenjie; Chen, Hongzhang

    2015-03-01

    The object of this work was to evaluate the effect of loading coefficient on steam explosion process and efficacy of corn stalk. Loading coefficient's relation with loading pattern and material property was first revealed, then its effect on transfer process and pretreatment efficacy of steam explosion was assessed by established models and enzymatic hydrolysis tests, respectively, in order to propose its optimization strategy for improving the process economy. Results showed that loading coefficient was mainly determined by loading pattern, moisture content and chip size. Both compact loading pattern and low moisture content improved the energy efficiency of steam explosion pretreatment and overall sugar yield of pretreated materials, indicating that they are desirable to improve the process economy. Pretreatment of small chip size showed opposite effects in pretreatment energy efficiency and enzymatic hydrolysis performance, thus its optimization should be balanced in investigated aspects according to further techno-economical evaluation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Study on load test of 100m cross-reinforced deck type concrete box arch bridge

    Science.gov (United States)

    Shi, Jing Xian; Cheng, Ying Jie

    2018-06-01

    Found in the routine quality inspection of highway bridge that many vertical fractures on the main beam (10mT beam) of the steel reinforced concrete arch bridge near the hydropower station. In order to grasp the bearing capacity of this bridge under working conditions with cracks, the static load and dynamic load test of box arch bridge are carried out. The Midas civil theory is calculated by using the special plate trailer - 300 as the calculation load, and the deflection and stress of the critical section are tested by the equivalent cloth load in the test vehicle. The pulsation test, obstacles and no obstacle driving test were carried out. Experimental results show that the bridge under the condition of the test loads is in safe condition, main bearing component of the strength and stiffness meet the design requirements, the crack width does not increase, in the process of loading bridge overall work performance is good.

  2. A new pressure chamber to study the biosynthetic response of articular cartilage to mechanical loading.

    Science.gov (United States)

    Steinmeyer, J; Torzilli, P A; Burton-Wurster, N; Lust, G

    1993-01-01

    A prototype chamber was used to apply a precise cyclic or static load on articular cartilage explants under sterile conditions. A variable pressure, pneumatic controller was constructed to power the chamber's air cylinder, capable of applying, with a porous load platen, loads of up to 10 MPa at cycles ranging from 0 to 10 Hz. Pig articular cartilage explants were maintained successfully in this chamber for 2 days under cyclic mechanical loading of 0.5 Hz, 0.5 MPa. Explants remained sterile, viable and metabolically active. Cartilage responded to this load with a decreased synthesis of fibronectin and a small but statistically significant elevation in proteoglycan content. Similar but less extensive effects on fibronectin synthesis were observed with the small static load (0.016 MPa) inherent in the design of the chamber.

  3. Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study

    Science.gov (United States)

    Madsen, Steen J.; Shih, En-Chung; Peng, Qian; Christie, Catherine; Krasieva, Tatiana; Hirschberg, Henry

    2016-01-01

    Moderate hyperthermia (MHT) has been shown to enhance the effects of chemotherapeutic agents in a wide variety of cancers. The purpose of this study was to investigate the combined effects of commonly used chemotherapeutic agents with MHT induced by near-infrared (NIR) activation of gold nanoshell (AuNS)-loaded macrophages (Ma). AuNS-loaded murine Ma combined with human FaDu squamous cells, in hybrid monolayers, were subjected to three cytotoxic drugs (doxorubicin, bleomycin, cisplatin) with or without NIR laser irradiation. For all three drugs, efficacy was increased by NIR activation of AuNS-loaded Ma. The results of this in vitro study provide proof-of-concept for the use of AuNS-loaded Ma for photothermal enhancement of the effects of chemotherapy on squamous cell carcinoma.

  4. The neural correlates of perceptual load induced attentional selection: an fMRI study.

    Science.gov (United States)

    Wei, P; Szameitat, A J; Müller, H J; Schubert, T; Zhou, X

    2013-10-10

    The neural correlates of perceptual load induced attentional selection were investigated in an functional magnetic resonance imaging (fMRI) experiment in which attentional selection was manipulated through the variation of perceptual load in target search. Participants searched for a vertically or horizontally oriented bar among heterogeneously (the high load condition) or homogeneously (the low load condition) oriented distractor bars in the central display, which was flanked by a vertical or horizontal bar presented at the left or the right periphery. The search reaction times were longer when the central display was of high load than of low load, and were longer when the flanker was incongruent than congruent with the target. Importantly, the flanker congruency effect was manifested only in the low load condition, not in the high load condition, indicating that the perceptual load in target search determined whether the task-irrelevant flanker was processed. Imaging analyses revealed a set of fronto-parietal regions having higher activations in the high than in the low load condition. Anterior cingulate cortex (ACC) was more activated for the incongruent than for the congruent trials. Moreover, ACC and bilateral anterior insula were sensitive to the interaction between perceptual load and flanker congruency such that the activation differences between the incongruent and congruent conditions were significant in the low, but not in the high load condition. These results are consistent with the claim that ACC and bilateral anterior insula may exert executive control by selectively biasing processing in favor of task-relevant information and this biasing depends on the resources currently available to the control system. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

  5. The deaf history of radio studies and the challenges of research on listening significations

    Directory of Open Access Journals (Sweden)

    Madalena Oliveira

    2013-06-01

    Full Text Available With more than 90 year-old history, radio has been neglected by media studies. Within mainstream media, radio is not only a blind medium but an invisible medium too in terms of scientific production on communication. This article reflects on the production of knowledge in this area and the challenges of studying a culture of listening in times dominated by the look. The point of view of this approach is based on scientific self-reflexivity and socio-semiotics analysis of radio.

  6. Design study of a plasma-loaded CRM using TPD-II machine

    International Nuclear Information System (INIS)

    Minami, Kazuo

    2007-08-01

    Design study of an experiment for plasma-loaded cyclotron resonance maser (CRM) utilizing TPD-II Machine at NIFS, Japan is described in some detail. The principle of gyrotrons has been believed the CRM instability. However, all the existing linear theories of CRM instability include unphysical modes unstable at infinite values of axial wavenumber that can never be observed experimentally. To overcome the difficulty, we derive and analyze numerically an exact linear dispersion relation of a large orbit electron beam for CRM, and removed the unphysical modes. However, the relation is found to include two principles of cyclotron emission with oscillation frequencies above and below the branch of fast electron cyclotron wave. The former is CRM instability, and the latter is named Chrenkov instability in the azimuthal direction (CIAD). It is noted that the CIAD we found remains only a proposal of a new mechanism for cyclotron emission until the physical existence is verified experimentally. To verify the CIAD, the design study of a plasma-loaded CRM has been carried out. The apparatus consists of two portions installed in the TPD-II: A pair of helical wiggler windings to create a mono-energetic beam with 15 keV and pitch factor V θ /V z ≥1, and microwave circuits including a cylindrical TE 011 mode cavity with resonant frequency 3.45 GHz. For high plasma density n≥1.5x10 11 cm -3 from TPD-II, the CRM instability may be suppressed and the CIAD will take turn. The present experimental study contributes to a deeper understanding and a widened future prospect in gyrotron physics. (author)

  7. Radiotracer study of wash load movement in a drum-type fabric washing machine using a gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Balt, A.P.; Brekel, L.D.M. van den; Vandecasteele, C.; Kolar, Z.

    1987-01-01

    A study was made of the movement of the wash loads in a drum-type washing machine. For this purpose a sup(99m)Tc source was attached to one or two separate textile pieces and the subsequent source positions were determined by means of a gamma-camera. The wash load movement pattern appears to depend on the type of textile material and its amount, as well as on the volume of water present in the washing machine.

  8. Blinded comparison of faecal loading on plain radiography versus radio-opaque marker transit studies in the assessment of constipation

    International Nuclear Information System (INIS)

    Cowlam, S.; Vinayagam, R.; Khan, U.; Marsden, S.; Minty, I.; Moncur, P.; Bain, I.; Yiannakou, Y.J.

    2008-01-01

    Aim: To compare faecal loading on plain radiography versus radio-opaque marker transit studies in the assessment of constipation. Methods: The study group was a convenience sample of patients attending the Durham Constipation Clinic. All patients underwent transit studies according to an established protocol, and severity of constipation was assessed contemporaneously using a validated questionnaire (PAC-SYM). Transit studies were performed using radio-opaque markers that were ingested over 3 consecutive days, with a radiograph taken on the fourth day. Digital images of the radiograph were digitally altered to remove all traces of the transit markers without affecting the underlying pattern of faecal loading. Four observers assessed faecal loading independently; two clinicians (C1 and C2) and two radiologists (R1 and R2). C1 and R1 used a previously described formal scoring method of assessing faecal loading, whereas C2 and R2 assessed the images as if they were in a clinic or reporting session, grading the faecal loading as mild, moderate, or severe. Results: One hundred patients were recruited out of 186 presenting in a 2-year period. All patients completed assessments. The correlation between observers was only fair to moderate (r ranging from 0.34-0.51). There were some surprisingly marked disagreements in 10-18% of assessments. The correlation between faecal loading and transit was weak for all observers (r ranging from 0.261-0.311). Symptom severity did not correlate with faecal loading. Conclusion: These results suggest that there is considerable inter-observer variation in the radiological assessment of faecal loading, irrespective of the training or method used by the observer, and that there is very poor correlation with colonic transit. The diagnosis of constipation, and the assessment of severity, is best performed clinically

  9. Blinded comparison of faecal loading on plain radiography versus radio-opaque marker transit studies in the assessment of constipation

    Energy Technology Data Exchange (ETDEWEB)

    Cowlam, S. [Sunderland Royal Hospital, Sunderland (United Kingdom); Vinayagam, R.; Khan, U.; Marsden, S.; Minty, I.; Moncur, P.; Bain, I. [University Hospital of North Durham, Durham (United Kingdom); Yiannakou, Y.J. [University Hospital of North Durham, Durham (United Kingdom)], E-mail: yan.yiannakou@cddft.nhs.uk

    2008-12-15

    Aim: To compare faecal loading on plain radiography versus radio-opaque marker transit studies in the assessment of constipation. Methods: The study group was a convenience sample of patients attending the Durham Constipation Clinic. All patients underwent transit studies according to an established protocol, and severity of constipation was assessed contemporaneously using a validated questionnaire (PAC-SYM). Transit studies were performed using radio-opaque markers that were ingested over 3 consecutive days, with a radiograph taken on the fourth day. Digital images of the radiograph were digitally altered to remove all traces of the transit markers without affecting the underlying pattern of faecal loading. Four observers assessed faecal loading independently; two clinicians (C1 and C2) and two radiologists (R1 and R2). C1 and R1 used a previously described formal scoring method of assessing faecal loading, whereas C2 and R2 assessed the images as if they were in a clinic or reporting session, grading the faecal loading as mild, moderate, or severe. Results: One hundred patients were recruited out of 186 presenting in a 2-year period. All patients completed assessments. The correlation between observers was only fair to moderate (r ranging from 0.34-0.51). There were some surprisingly marked disagreements in 10-18% of assessments. The correlation between faecal loading and transit was weak for all observers (r ranging from 0.261-0.311). Symptom severity did not correlate with faecal loading. Conclusion: These results suggest that there is considerable inter-observer variation in the radiological assessment of faecal loading, irrespective of the training or method used by the observer, and that there is very poor correlation with colonic transit. The diagnosis of constipation, and the assessment of severity, is best performed clinically.

  10. A study of two kinds of electromagnetic pulse antennas with a continuous resistive loading using the FDTD method

    International Nuclear Information System (INIS)

    Mao Congguang; Zhou Hui

    2003-01-01

    The cylindrical and conical monopole antenna with a continuous resistive loading is considered as a radiator in the experiments of the electromagnetic pulse compatibility. The various principle of the resistive loading is discussed in details and the characters of the antennas are studied using the Finite-Difference Time-Domain (FDTD) method. The key techniques of the calculating are presented. The results are in good agreement with the documents and the theory

  11. Radiotracer study of wash load movement in a drum-type fabric washing machine using a gamma camera

    International Nuclear Information System (INIS)

    Balt, A.P.; Brekel, L.D.M. van den; Vandecasteele, C.; Kolar, Z.

    1987-01-01

    A study was made of the movement of the wash loads in a drum-type washing machine. For this purpose a sup(99m)Tc source was attached to one or two separate textile pieces and the subsequent source positions were determined by means of a gamma-camera. The wash load movement pattern appears to depend on the type of textile material and its amount, as well as on the volume of water present in the washing machine. (author)

  12. A micromechanical study of the damage mechanics of acrylic particulate composites under thermomechanical loading

    Science.gov (United States)

    Nie, Shihua

    The main aim of this dissertation was to characterize the damage mechanism and fatigue behavior of the acrylic particulate composite. This dissertation also investigated how the failure mechanism is influenced by changes in certain parameters including the volume fraction of particle, the interfacial bonding strength, the stiffness and thickness of the interphase, and the CTE mismatch between the particle and the matrix. Monotonic uniaxial tensile and compressive testing under various temperatures and strain rates, isothermal low-cycle mechanical testing and thermal cycling of a plate with a cutout were performed. The influence of the interfacial bonding strength between the particle and the matrix on the failure mechanism of the ATH filled PMMA was investigated using in situ observations under uniaxial loading conditions. For composites with weak interfacial bonding, the debonding is the major damage mode. For composites with strong interfacial bonding, the breakage of the agglomerate of particles is the major damage mode. Experimental studies also demonstrated the significant influence of interfacial bonding strength on the fatigue life of the ATH filled PMMA. The damage was characterized in terms of the elastic modulus degradation, the load-drop parameter, the plastic strain range and the hysteresis dissipation. Identifying the internal state variables that quantify material degradation under thermomechanical loading is an active research field. In this dissertation, the entropy production, which is a measure of the irreversibility of the thermodynamic system, is used as the metric for damage. The close correlation between the damage measured in terms of elastic modulus degradation and that obtained from the finite element simulation results validates the entropy based damage evolution function. A micromechanical model for acrylic particulate composites with imperfect interfacial bonds was proposed. Acrylic particulate composites are treated as three

  13. History and the Study of "Administration" (LAMPS) in Education: A Reflection on an Editorial for a Special Issue

    Science.gov (United States)

    Ribbins, Peter

    2008-01-01

    The special edition of JEAH published in August 2006 on "Administration and Leadership in Education: A Case for History?" argued that history has been seriously undervalued in the study of administration and leadership in education. My introductory editorial explained why this mattered and outlined the framework in which the papers it…

  14. Life-history strategies as a tool to identify conservation constraints: A case-study on ants in chalk grasslands

    NARCIS (Netherlands)

    Noordwijk, C.G.E.; Boer, P.; Mabelis, A.A.; Verberk, W.C.E.P.; Siepel, H.

    2012-01-01

    Species’ life-history traits underlie species–environment relationships. Therefore, analysis of species traits, combined into life-history strategies, can be used to identify key factors shaping the local species composition. This is demonstrated in a case-study on ants in chalk grasslands. We

  15. The History and Future of the Southern Bible Institute: A Post-Secondary School of Biblical Studies for African Americans

    Science.gov (United States)

    Cooks, Michael

    2010-01-01

    The United States of America has a long history in higher education, but one area of its history not exhausted through research involves higher education for African Americans. Specifically, higher education for African Americans in the area of theology or biblical studies presents numerous opportunities for further research. Soon after the…

  16. Comparative study of the prevalence of suicidal behavior and sexual abuse history in delinquent and non-delinquent adolescents.

    Science.gov (United States)

    Matsumoto, Toshihiko; Tsutsumi, Atsuro; Izutsu, Takashi; Imamura, Fumi; Chiba, Yasuhiko; Takeshima, Tadashi

    2009-04-01

    The present study examined the prevalence of suicidal behavior and sexual abuse history in delinquent and non-delinquent adolescents aged 15-17 years. Results showed that delinquent adolescents, particularly girls, more frequently reported histories of suicidal behavior and sexual abuse than non-delinquent adolescents.

  17. Study the effect of dye concentration on optical history using circular polarization holographic grating in thin polymeric film

    International Nuclear Information System (INIS)

    Mohajerani, E.; Hosain Nataj, N.

    2006-01-01

    By studying the effect of dye concentration, we obtained the optimal dye concentration for recording holographic gratings. The history of circular polarization grating is also investigated. We built polarization holographic grating with more than 2 weeks history. By using a mask in front of pump beam, different pictures could be built up in the film.

  18. The impact of a family history of hearing problems on those with hearing difficulties themselves: an exploratory study

    NARCIS (Netherlands)

    Stephens, D.; Kramer, S.E.

    2005-01-01

    The objective of the study was to investigate the effects of a family history of hearing impairment on those people with the hearing impairment themselves. The subjects were 102 consecutive patients with a family history of hearing impairment, seen in an audiological rehabilitation clinic. Each was

  19. A Case Study of the In-Class Use of a Video Game for Teaching High School History

    Science.gov (United States)

    Watson, William R.; Mong, Christopher J.; Harris, Constance A.

    2011-01-01

    This study examines the case of a sophomore high school history class where "Making History", a video game designed with educational purposes in mind, is used in the classroom to teach about World War II. Data was gathered using observation, focus group and individual interviews, and document analysis. The high school was a rural school…

  20. STANDALONE PHOTOVOLTAIC SYSTEMS SIZING OPTIMIZATION USING DESIGN SPACE APPROACH: CASE STUDY FOR RESIDENTIAL LIGHTING LOAD

    Directory of Open Access Journals (Sweden)

    D. F. AL RIZA

    2015-07-01

    Full Text Available This paper presents a sizing optimization methodology of panel and battery capacity in a standalone photovoltaic system with lighting load. Performance of the system is identified by performing Loss of Power Supply Probability (LPSP calculation. Input data used for the calculation is the daily weather data and system components parameters. Capital Cost and Life Cycle Cost (LCC is calculated as optimization parameters. Design space for optimum system configuration is identified based on a given LPSP value, Capital Cost and Life Cycle Cost. Excess energy value is used as an over-design indicator in the design space. An economic analysis, including cost of the energy and payback period, for selected configurations are also studied.

  1. Experimental Studies on Behaviour of Reinforced Geopolymer Concrete Beams Subjected to Monotonic Static Loading

    Science.gov (United States)

    Madheswaran, C. K.; Ambily, P. S.; Dattatreya, J. K.; Ramesh, G.

    2015-06-01

    This work describes the experimental investigation on behaviour of reinforced GPC beams subjected to monotonic static loading. The overall dimensions of the GPC beams are 250 mm × 300 mm × 2200 mm. The effective span of beam is 1600 mm. The beams have been designed to be critical in shear as per IS:456 provisions. The specimens were produced from a mix incorporating fly ash and ground granulated blast furnace slag, which was designed for a compressive strength of 40 MPa at 28 days. The reinforced concrete specimens are subjected to curing at ambient temperature under wet burlap. The parameters being investigated include shear span to depth ratio (a/d = 1.5 and 2.0). Experiments are conducted on 12 GPC beams and four OPCC control beams. All the beams are tested using 2000 kN servo-controlled hydraulic actuator. This paper presents the results of experimental studies.

  2. Influence of gender, parity, and caloric load on gastrorectal response in healthy subjects: a barostat study.

    Science.gov (United States)

    Sloots, Cornelius E J; Felt-Bersma, Richelle J F; Meuwissen, Stephan G M; Kuipers, Ernst J

    2003-03-01

    The gastrocolonic response consists of a prompt increase in colonic tone after a meal. With a barostat and a high compliant air-filled bag, it is possible to measure rectal tone by recording changes in volume at a constant intrabag pressure. The aim of this study was to evaluate the gastrorectal response in males and females as well as the effect of different caloric loads on the gastrorectal response. In 33 volunteers a barostat procedure during basal conditions and after a 600-kcal meal was performed. In 26 volunteers the procedure was repeated with a 1000-kcal meal. A meal response was defined as a decrease in volume of more than 10%. Phasic volume events (PVE) were defined as a 10% decrease in volume of 15-60 sec duration. After a 600-kcal meal, the decrease in volume after 1 hr was 28 +/- 7% (mean +/- SEM, P parity should be made when results are compared.

  3. Experimental study on surface wrinkling of silicon monoxide film on compliant substrate under thermally induced loads

    Science.gov (United States)

    Li, Chuanwei; Kong, Yingxiao; Jiang, Wenchong; Wang, Zhiyong; Li, Linan; Wang, Shibin

    2017-06-01

    The wrinkling of a silicon monoxide thin film on a compliant poly(dimethylsiloxane) (PDMS) substrate structure was experimentally investigated in this study. The self-expansion effect of PDMS during film deposition was utilized to impose a pretensile strain on the structure through a specially made fixture. A laser scanning confocal microscope (LSCM) system with an in situ heating stage was employed for the real-time measurement. The Young’s modulus of the silicon monoxide thin film as well as the PDMS substrate was measured on the basis of the elasticity theory. Moreover, the effects of temperature variations on geometric parameters in the postbuckling state, such as wavelength and amplitude, were analyzed. It was proved that wavelength is relatively immune to thermal loads, while amplitude is much more sensitive.

  4. Experimental and numerical study of plastic shear instability under high-speed loading conditions

    International Nuclear Information System (INIS)

    Sokovikov, Mikhail; Chudinov, Vasiliy; Bilalov, Dmitry; Oborin, Vladimir; Uvarov, Sergey; Plekhov, Oleg; Terekhina, Alena; Naimark, Oleg

    2014-01-01

    The behavior of specimens dynamically loaded during the split Hopkinson (Kolsky) bar tests in a regime close to simple shear conditions was studied. The lateral surface of the specimens was investigated in a real-time mode with the aid of a high-speed infra-red camera CEDIP Silver 450M. The temperature field distribution obtained at different time made it possible to trace the evolution of plastic strain localization. The process of target perforation involving plug formation and ejection was examined using a high-speed infra-red camera and a VISAR velocity measurement system. The microstructure of tested specimens was analyzed using an optical interferometer-profilometer and a scanning electron microscope. The development of plastic shear instability regions has been simulated numerically

  5. Glycemic index, glycemic load and mammographic breast density: the EPIC Florence longitudinal study.

    Directory of Open Access Journals (Sweden)

    Giovanna Masala

    Full Text Available A few studies have evaluated the association between diet and mammographic breast density (MBD and results are inconsistent. MBD, a well-recognized risk factor for breast cancer, has been proposed as a marker of cumulative exposure to hormones and growth factors. Diets with a high glycemic index (GI or glycemic load (GL may increase breast cancer risk, via an effect on the insulin-like growth factor axis. We have investigated the association between carbohydrate intake, GI, GL and MBD in a prospective study. We identified a large series of women, in the frame of the EPIC-Florence cohort, with a mammogram taken five years after enrolment, when detailed information on dietary and lifestyle habits and anthropometric measurements had been collected. Mammograms have been retrieved (1,668, 83% and MBD assessed according to Wolfe's classification. We compared women with high MBD (P2+DY Wolfe's categories with those with low MBD (N1+P1 through logistic models adjusted for age, education, body mass index, menopause, number of children, breast feeding, physical activity, non-alcohol energy, fibers, saturated fat and alcohol. A direct association between GL and high MBD emerged in the highest quintile of intake in comparison with the lowest quintile (OR = 1.73, 95%CI 1.13-2.67, p for trend = 0.048 while no association with glycemic index was evident. These results were confirmed after exclusion of women reporting to be on a diet or affected with diabetes, and when Hormone Replacement Therapy at the date of mammographic examination used to assess MBD was considered. The effect was particularly evident among leaner women, although no interaction was found. A positive association was suggested for increasing simple sugar and total carbohydrates intakes limited to the highest quintiles. In this Italian population we observed an association between glycemic load, total and rapidly absorbed carbohydrates and high MBD. These novel results warrant further

  6. Study of the dynamic fragmentation of laser shock-loaded metallic target

    International Nuclear Information System (INIS)

    Lescoute, E.

    2010-01-01

    The irradiation of a metallic target by a high power laser pulse induces a shock wave in the material. Under some conditions, it leads to the production of high velocity ejecta which can damage the optical environment (lenses, mirrors, windows, etc.). With the ongoing development of high energy laser facilities designed to achieve inertial confinement fusion, such as the Laser MegaJoule in France or the National Ignition Facility in the USA, the question of debris ejection from metallic samples subjected to intense laser irradiation has become a key issue. It is necessary to understand fragmentation processes induced by laser shock, and to anticipate and quantify generated fragments, in order to design suitable protections and experiments, and to preserve laser facilities. The main fragmentation processes which can occur in a laser-shock-loaded metallic target and generate high velocity ejecta are: (i) micro-jetting, which occurs upon reflection of the incident compressive front from the free surface, (ii) spallation, which is due to the later interaction of the release wave reflected from that surface with the incident unloading wave and (iii) dynamic punching of thin targets. Experimental campaigns have been performed on high energy laser facilities in the Centre d'Etudes Scientifiques et Techniques d'Aquitaine (CESTA, CEA, Alise facility) and in the Laboratoire pour l'Utilisation des Lasers Intenses (LULI, Ecole Polytechnique, LULI 2000 facility). Gold and aluminium have been mainly studied because they are the two main metallic components of the target which will be used to achieved the inertial confinement fusion. Specific diagnostics have been developed and used during these experiments to study the dynamic fragmentation: transverse shadowgraphy, free surface velocity measurement and recovery of generated fragments. Experimental results have been compared with numerical predictions obtained with a bi-dimensional hydrodynamic code, where a specific numerical

  7. Experimental study of the anisotropic properties of argillite under moisture and mechanical loads

    International Nuclear Information System (INIS)

    Yang, D.S.; Chanchole, S.; Wang, L.L.; Bornert, M.; Gatmiri, B.

    2012-01-01

    Document available in extended abstract form only. Due to various factors, such as sedimentation, layered morphology of clay mineral, in-situ stress, etc., the behavior of argillite rocks is often anisotropic. In order to study the anisotropy of the Callovo-Oxfordian (COx) argillite considered as a possible host rock for high-level radioactive nuclear waste repository in France, a series of tests including uniaxial compression and dehydration and hydration at different constant applied stress levels, are carried out using a specific setup combining mechanical and moisture loading devices. During these hydro-mechanical tests, this specific setup can also continuously capture images of the sample surfaces to be subsequently analyzed using Digital Image Correlation techniques (DIC) in order to determine full-field strains. In this study, three sampling directions are used with the angle θ between the bedding plane and the cylindrical sample axis equal to 45 deg., 60 deg. and 90 deg.. To investigate the mechanical anisotropy, uniaxial compressive tests with mechanical loading and unloading cycles are performed on several different samples at the same moisture level. The results show that the mechanical parameters (apparent modulus, failure stress) depend on loading orientation relative to the stratification plane. For a given water content, the failure stress reaches maximum values for θ =90 deg. and minimum values for θ =45 deg.. To study the hydric anisotropy, dehydration and hydration tests under stress-free conditions are performed on two cylindrical samples (θ=90 deg. and θ=60 deg.). Three cycles of hydration and dehydration are carried out by varying the relative humidity between 40% and 95%. The sample weight, the deformation measured by strain gages and the relative humidity are continuously recorded during the test by means of another specific setup described in [Pham et al., 2007]. Fig.1a illustrates the evolution of the strains of the sample EST28030-No

  8. Haptic and Olfactory Experiences of the Perth Foreshore: Case Studies in Sensory History

    Directory of Open Access Journals (Sweden)

    Saren Reid

    2015-11-01

    Full Text Available The liminal zone where a city meets ‘the water’s edge’ is a place of heightened sensory experiences. In Australia, these settings have been continually reshaped and experienced, individually and collectively, both before and after European settlement, and so they provide a physical domain for reinterpreting Australian history. In Perth, Western Australia, at the turn of the twentieth century, two recreational buildings on the foreshore, the Perth City Baths (1898–1914 and the Water Chute (1905–unknown, promoted new aquatic leisure practices that provided heightened sensory experiences of the Swan River and the city foreshore. These buildings are examined from the perspective of ‘sensory history’, an alternative form of cultural and environmental analysis that has been garnering interest from a range of disciplines over the past several decades (see, for example, the work of Constance Classen, Alain Corbin, David Howes and Mark M Smith. Sensory history seeks to reveal through historical inquiry the informative and exploratory nature of the senses in specific contexts. The potential value of sensory history to studies of built and natural environments lies in drawing attention away from the overweening and frequently generalising dominance of ‘the visual’ as a critical category in humanities research. The case studies explore how evolving swimming practices at the City Baths and ‘shooting the chutes’ at the Water Chute provided novel, exciting and sometimes unpleasant haptic and olfactory experiences and consider how changing forms of recreation allowed for broadly sensuous rather than primarily visual experiences of the foreshore and Swan River. These case studies are part of a larger body of research that seeks to ‘make sense’ of the Perth foreshore and, more broadly, Australian urban waterfronts as sites of varied and evolving sensory experience.

  9. Electric utility load management: rational use of energy program pilot study

    Energy Technology Data Exchange (ETDEWEB)

    1977-08-01

    In recognition of the role that load management can play in ensuring that the growing demand for electricity is met in a cost- and energy-efficient manner, in mid-1974, the NATO Committee on the Challenges of Modern Society sponsored all three meetings to provide a forum for representatives of U.S. and European utilities to exchange views and experiences on the various aspects of load management. It was the consensus of representatives at the meetings that three overall approaches offer significant opportunities for achieving improved load management: development of marginal-cost rate structures; power pooling and energy storage by utilities; and efforts by consumers. Industrial consumers can assist electric utilities in their efforts to level system loads through three important methods: interruptible power and deferred load control; peak self-generation; and shifts in operating schedules. Residential/commercial consumers also have an important role to play by managing both their electric heating load (through the interruption of direct-resistance heating and the storage of heat) and their air conditioning load. In response to the interest expressed by the participants in the CCMS conferences, the U.S. and several European governments, national electric utility industry organizations, state public utility commissions, and many individual utilities have undertaken R and D projects to investigate and test various aspects of these three approaches to load management. This report describes the projects that were presented by the utility representatives.

  10. Load consequences when sweeping blades - A case study of a 5 MW pitch controlled wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Verelst, D.R.S.; Larsen, Torben J.

    2010-08-15

    The generic 5 MW NREL wind turbine model is used in Risoe's aeroelastic simulator HAWC2 to investigate 120 different swept blade configurations (forward and backward sweep). Sensitivity for 2 different controllers is considered as well. Backward sweep results in a pitch to feather torsional moment of the blade, effectively reducing blade twist angles under increased loading. This behaviour results in decreased flap-wise fatigue and extreme loads, an increase for edge-wise fatigue loading and status quo or slight decrease in extreme loads (depending on the controller). Tower base and shaft-end bending moments are reduced as well. Forward sweep leads to an increase in angle of attack under loading. For a pitch controlled turbine this leads to an increase in fatigue and extreme loading in all cases. A controller inflicted instability is present for the more extreme forward swept cases. Due to the shape of considered sweep curves, an inherent and significant increase in torsional blade root bending moment is noted. A boomerang shaped sweep curve is proposed to counteract this problematic increased loading. Controller sensitivity shows that adding sweep affects some loadings differently. Power output is reduced for backward sweep since the blade twist is optimized as a rigid structure, ignoring the torsional deformations which for a swept blade can be significant. (author)

  11. Maternal history of child abuse moderates the association between daily stress and diurnal cortisol in pregnancy: a pilot study.

    Science.gov (United States)

    Bublitz, Margaret H; Stroud, Laura R

    2013-11-01

    Previous research on the association between maternal daily stress and cortisol in pregnancy has yielded inconsistent findings. However, past studies have not considered whether stressful experiences in childhood impact maternal cortisol regulation in pregnancy. In this pilot study, we aimed to examine whether the association between maternal daily stress and cortisol differed according to maternal history of child abuse. Forty-one women provided salivary cortisol samples at wake-up, 30 min after wake-up, and bedtime for 3 days at three times over second and third trimesters of pregnancy. On each day of cortisol collection women reported their daily stress. Women reported child abuse experiences prior to age 18 years by completing 15 items from the Adverse Childhood Experiences Scale. Twenty-one percent (N = 9) of women reported a history of child sexual abuse (CSA), 44% (N = 18) reported a history of non-sexual child abuse and 34% (N = 14) reported no history of child abuse. Hierarchical Linear Modeling (HLM) analyses revealed that stress in the day prior was associated with increases in morning cortisol in women with CSA histories compared to women with non-sexual abuse histories or no history of child abuse. Increases in evening cortisol were associated with increases in daily stress in women with CSA histories compared to women with non-sexual abuse histories or no history of child abuse. Results reveal a dynamic association between daily stress and cortisol in pregnancy and suggest that patterns differ according to maternal child abuse history.

  12. Atorvastatin calcium loaded chitosan nanoparticles: in vitro evaluation and in vivo pharmacokinetic studies in rabbits

    Directory of Open Access Journals (Sweden)

    Abdul Baquee Ahmed

    2015-06-01

    Full Text Available In this study, we prepared atorvastatin calcium (AVST loaded chitosan nanoparticles to improve the oral bioavailability of the drug. Nanoparticles were prepared by solvent evaporation technique and evaluated for its particle size, entrapment efficiency, zeta potential, in vitro release and surface morphology by scanning electron microscopy (SEM. In addition, the pharmacokinetics of AVST from the optimized formulation (FT5 was compared with marketed immediate release formulation (Atorva(r in rabbits. Particle size of prepared nanoparticles was ranged between 179.3 ± 7.12 to 256.8 ± 8.24 nm with a low polydispersity index (PI value. Zeta potential study showed that the particles are stable with positive values between 13.03 ± 0.32 to 46.90 ± 0.49 mV. FT-IR studies confirmed the absence of incompatibility of AVST with excipient used in the formulations. In vitro release study showed that the drug release was sustained for 48 h. Results of pharmacokinetics study showed significant changes in the pharmacokinetic parameter (2.2 fold increase in AUC of the optimized formulation as compared to marketed formulation (Atorva(r. Thus, the developed nanoparticles evidenced the improvement of oral bioavailability of AVST in rabbit model.

  13. Changing psychology: history and legacy of the Society for the Psychological Study of Ethnic Minority Issues.

    Science.gov (United States)

    Comas-Díaz, Lillian

    2009-10-01

    The history and legacy of the Society for the Psychological Study of Ethnic Minority Issues (American Psychological Association Division 45) for its first 20 years are reviewed. The legitimization of the ethnic minority scholarship within organized psychology is chronicled, highlighting the central role of advocacy and activism. Multiculturalism is presented as a paradigm for the globalization of the United States. It is concluded that ethnic minority psychology has changed the field and equips us for the challenges of the internationalization of the world. Copyright 2009 APA, all rights reserved.

  14. Experimental study on the wave loads on a rotor of the WEPTOS Wave Energy Converter

    DEFF Research Database (Denmark)

    Pecher, Arthur; Kofoed, Jens Peter

    Experimental tests have been performed to investigate the wave load on the rotor in design wave conditions. These wave loads should give an indication of the required structural strength around the rotors as well as for other equipment such as the bearings. During the lab tests, the wave loads have...... been measured for the following configurations: • Head and beam seas (wave coming from the front and the side) • For three different submergence levels • For three different dispositions of the rotor (free to rotate, and fixed at 50° and 90°) Based on this results, an estimation of the maximum wave...... loads has been made on the maximum wave loads at the DanWEC test site....

  15. A literature study on the effects of cyclic lateral loading of monopiles in cohesionless soils

    Energy Technology Data Exchange (ETDEWEB)

    Lange Rasmussen, K. [Niras, Aalborg (Denmark); Hansen, Mette; Kirk Wolf, T. [COWI, Kgs. Lyngby, (Denmark); Ibsen, L.B.; Ravn Roesen, H. [Aalborg Univ.. Dept. of Civil Engineering, Aalborg (Denmark)

    2013-06-15

    Today, monopiles are the most typical foundation for offshore wind turbines. During their lifetime large diameter, stiff piles are subjected to millions of small cyclic loads due to environmental forces. The long-term cyclic loading can change the granular structure of the soil surrounding the pile. This may change the stiffness of the soil-pile system and create an accumulated rotation of the pile. The behaviour of the soil-pile system is very complex and the influence of soil parameters, number of load cycles, and size, amplitude and characteristic of the load are examined, as they all contribute to the rotation and the change in stiffness. The scope of this article is to outline current design methods and the state of the art knowledge within the subject of long-term cyclic, lateral loading of piles. (Author)

  16. Rib fractures under anterior-posterior dynamic loads: experimental and finite-element study.

    Science.gov (United States)

    Li, Zuoping; Kindig, Matthew W; Kerrigan, Jason R; Untaroiu, Costin D; Subit, Damien; Crandall, Jeff R; Kent, Richard W

    2010-01-19

    The purpose of this study was to investigate whether using a finite-element (FE) mesh composed entirely of hexahedral elements to model cortical and trabecular bone (all-hex model) would provide more accurate simulations than those with variable thickness shell elements for cortical bone and hexahedral elements for trabecular bone (hex-shell model) in the modeling human ribs. First, quasi-static non-injurious and dynamic injurious experiments were performed using the second, fourth, and tenth human thoracic ribs to record the structural behavior and fracture tolerance of individual ribs under anterior-posterior bending loads. Then, all-hex and hex-shell FE models for the three ribs were developed using an octree-based and multi-block hex meshing approach, respectively. Material properties of cortical bone were optimized using dynamic experimental data and the hex-shell model of the fourth rib and trabecular bone properties were taken from the literature. Overall, the reaction force-displacement relationship predicted by both all-hex and hex-shell models with nodes in the offset middle-cortical surfaces compared well with those measured experimentally for all the three ribs. With the exception of fracture locations, the predictions from all-hex and offset hex-shell models of the second and fourth ribs agreed better with experimental data than those from the tenth rib models in terms of reaction force at fracture (difference rib responses and bone fractures for the loading conditions considered, but coarse hex-shell models with constant or variable shell thickness were more computationally efficient and therefore preferred. Copyright 2009 Elsevier Ltd. All rights reserved.

  17. Sustained release donepezil loaded PLGA microspheres for injection: Preparation, in vitro and in vivo study

    Directory of Open Access Journals (Sweden)

    Wenjia Guo

    2015-10-01

    Full Text Available The purpose of this study was to develop a PLGA microspheres-based donepezil (DP formulation which was expected to sustain release of DP for one week with high encapsulation efficiency (EE. DP derived from donepezil hydrochloride was encapsulated in PLGA microspheres by the O/W emulsion-solvent evaporation method. The optimized formulation which avoided the crushing of microspheres during the preparation process was characterized in terms of particle size, morphology, drug loading and EE, physical state of DP in the matrix and in vitro and in vivo release behavior. DP microspheres were prepared successfully with average diameter of 30 µm, drug loading of 15.92 ± 0.31% and EE up to 78.79 ± 2.56%. Scanning electron microscope image showed it has integrated spherical shape with no drug crystal and porous on its surface. Differential scanning calorimetry and X-ray diffraction results suggested DP was in amorphous state or molecularly dispersed in microspheres. The Tg of PLGA was increased with the addition of DP. The release profile in vitro was characterized with slow but continuous release that lasted for about one week and fitted well with first-order model, which suggested the diffusion governing release mechanism. After single-dose administration of DP microspheres via subcutaneous injection in rats, the plasma concentration of DP reached peak concentration at 0.50 d, and then declined gradually, but was still detectable at 15 d. A good correlation between in vitro and in vivo data was obtained. The results suggest the potential use of DP microspheres for treatment of Alzheimer's disease over long periods.

  18. Parametric studies on containment thermal hydraulic loads during high pressure melt ejection in a BWR

    Energy Technology Data Exchange (ETDEWEB)

    Silde, A.; Lindholm, I. [VTT Energy, Espoo (Finland)

    1997-12-01

    The containment thermal hydraulic loads during high pressure melt ejection in a Nordic BWR are studied parametrically with the CONTAIN and the MELCOR codes. The work is part of the Nordic RAK-2 project. The containment analyses were divided into two categories according to composition of the discharged debris: metallic and oxidic debris cases. In the base case with highly metallic debris, all sources from the reactor coolant system to the containment were based on the MELCOR/BH calculation. In the base case with the oxidic debris, the source data was specified assuming that {approx} 15% of the whole core material inventory and 34,000 kg of saturated water was discharged from the reactor pressure vessel (RPV) during 30 seconds. In this case, the debris consisted mostly of oxides. The highest predicted containment pressure peaks were about 8.5 bar. In the scenarios with highly metallic debris source, very high gas temperature of about 1900 K was predicted in the pedestal, and about 1400 K in the upper drywell. The calculations with metallic debris were sensititive to model parameters, like the particle size and the parameters, which control the chemical reaction kinetics. In the scenarios with oxidic debris source, the predicted pressure peaks were comparable to the cases with the metallic debris source. The maximum gas temperatures (about 450-500 K) in the containment were, however, significantly lower than in the respective metallic debris case. The temperatures were also insensitive to parametric variations. In addition, one analysis was performed with the MELCOR code for benchmarking of the MELCOR capabilities against the more detailed CONTAIN code. The calculations showed that leak tightness of the containment penetrations could be jeopardized due to high temperature loads, if a high pressure melt ejection occurred during a severe accident. Another consequence would be an early containment venting. (au). 28 refs.

  19. Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study

    Science.gov (United States)

    Koblizek, Vladimir; Milenkovic, Branislava; Barczyk, Adam; Tkacova, Ruzena; Somfay, Attila; Zykov, Kirill; Tudoric, Neven; Kostov, Kosta; Zbozinkova, Zuzana; Svancara, Jan; Sorli, Jurij; Krams, Alvils; Miravitlles, Marc

    2017-01-01

    Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region. Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment. 3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma–COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma–COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes. The majority of patients with stable COPD in CEE are nonexacerbators; however, there are distinct differences in surrogates of disease severity and therapy between predefined COPD phenotypes. PMID:28495687

  20. Study on erbium loading method to improve reactivity coefficients for low radiotoxic spent fuel HTGR

    Energy Technology Data Exchange (ETDEWEB)

    Fukaya, Y., E-mail: fukaya.yuji@jaea.go.jp; Goto, M.; Nishihara, T.

    2015-11-15

    Highlights: • We attempted and optimized erbium loading methods to improve reactivity coefficients for LRSF-HTGR. • We elucidated the mechanism of the improvements for each erbium loading method by using the Bondarenko approach. • We concluded the erbium loading method by embedding into graphite shaft is preferable. - Abstract: Erbium loading methods are investigated to improve reactivity coefficients of Low Radiotoxic Spent Fuel High Temperature Gas-cooled Reactor (LRSF-HTGR). Highly enriched uranium is used for fuel to reduce the generation of toxicity from uranium-238. The power coefficients are positive without the use of any additive. Then, the erbium is loaded into the core to obtain negative reactivity coefficients owing to the large resonance the peak of neutron capture reaction of erbium-167. The loading methods are attempted to find the suitable method for LRSF-HTGR. The erbium is mixed in a CPF fuel kernel, loaded by binary packing with fuel particles and erbium particles, and embedded into the graphite shaft deployed in the center of the fuel compact. It is found that erbium loading causes negative reactivity as moderator temperature reactivity, and from the viewpoint of heat transfer, it should be loaded into fuel pin elements for pin-in-block type fuel. Moreover, the erbium should be incinerated slowly to obtain negative reactivity coefficients even at the End Of Cycle (EOC). A loading method that effectively causes self-shielding should be selected to avoid incineration with burn-up. The incineration mechanism is elucidated using the Bondarenko approach. As a result, it is concluded that erbium embedded into graphite shaft is preferable for LRSF-HTGR to ensure that the reactivity coefficients remain negative at EOC.

  1. Selection History Modulates Working Memory Capacity

    Directory of Open Access Journals (Sweden)

    Bo-Cheng Kuo

    2016-10-01

    Full Text Available Recent studies have shown that past selection history affects the allocation of attention on target selection. However, it is unclear whether context-driven selection history can modulate the efficacy of attention allocation on working memory (WM representations. This study tests the influences of selection history on WM capacity. A display of one item (low load or three/four items (high load was shown for the participants to hold in WM in a delayed response task. Participants then judged whether a probe item was in the memory display or not. Selection history was defined as the number of items attended across trials in the task context within a block, manipulated by the stimulus set-size in the contexts with fewer possible stimuli (4-item or 5-item context or more possible stimuli (8-item or 9-item context from which the memorized content was selected. The capacity measure (i.e. the K parameter was estimated to reflect the number of items that can be held in WM. Across four behavioral experiments, the results revealed that the capacity was significantly reduced in the context with more possible stimuli relative to the context with fewer possible stimuli. Moreover, the reduction in capacity was significant for high WM load and not observed when the focus was on only a single item. Together, these findings indicate that context-driven selection history and focused attention influence WM capacity.

  2. A Comparative Study of Harnessing Cattle - An Important Chapter in the History of European Ethnology

    Czech Academy of Sciences Publication Activity Database

    Woitsch, Jiří

    2017-01-01

    Roč. 38, č. 2017 (2017), s. 59-89 ISSN 1335-4116 R&D Projects: GA ČR GA15-03754S Institutional support: RVO:68378076 Keywords : harnessing cattle * European ethnology * history of ethnology Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  3. Comparison study of time history and response spectrum responses for multiply supported piping systems

    International Nuclear Information System (INIS)

    Wang, Y.K.; Subudhi, M.; Bezler, P.

    1983-01-01

    In the past decade, several investigators have studied the problem of independent support excitation of a multiply supported piping system to identify the real need for such an analysis. This approach offers an increase in accuracy at a small increase in computational costs. To assess the method, studies based on the response spectrum approach using independent support motions for each group of commonly connected supports were performed. The results obtained from this approach were compared with the conventional envelope spectrum and time history solutions. The present study includes a mathematical formulation of the independent support motion analysis method suitable for implementation into an existing all purpose piping code PSAFE2 and a comparison of the solutions for some typical piping system using both Time History and Response Spectrum Methods. The results obtained from the Response Spectrum Methods represent the upper bound solution at most points in the piping system. Similarly, the Seismic Anchor Movement analysis based on the SRP method over predicts the responses near the support points and under predicts at points away from the supports

  4. Teaching Local History Using Social Studies Models for Turkish Middle School Students

    Science.gov (United States)

    Oguzhan, Karadeniz

    2015-01-01

    Local history teaching provides students the opportunity to gain first-hand experience by improving awareness of history. Students having active communication with their neighbourhood are given the opportunity to learn about themselves and their past, words and concepts about the past and they can make easier connection between history and other…

  5. Accounting History in Undergraduate Introductory Financial Accounting Courses: An Exploratory Study.

    Science.gov (United States)

    Williams, Satina V.; Schwartz, Bill N.

    2002-01-01

    Accounting faculty surveyed (n=45) did not overwhelmingly support incorporating accounting history into introductory courses, despite Accounting Education Change Commission recommendations. They did not support a separate course or believe history would attract more students. Attitudes of those already including history did not differ greatly from…

  6. Digital History: Using the Internet to Enhance African American Studies in the Secondary School

    Science.gov (United States)

    Scheuerell, Scott; Jaeger, Matt

    2015-01-01

    The authors discuss how high school students participated in a unit in which they learned about African American history in a 1:1 computer classroom--in particular, how they were able to use digital history to learn about a variety of African American leaders who are not frequently covered in the traditional American History textbook. In addition,…

  7. [Thoughts and methods of study on acupuncture medical history: an example of Mr. MA Ji-Xing].

    Science.gov (United States)

    Yang, Feng; Zhu, Ling

    2014-03-01

    Mr. MA Ji-xing has devoted himself into the study of acupuncture medical history for more than 70 years. As a result, a great work of Zhenjiuxue Tongshi (see text), History of Acupuncture-Moxibustion) has been completed. The author has expensively studied for history of acupuncture medicine in time and space. Base on abundant historical materials, deliberate textual research as well as strategically situated academic view, it is considered as a masterpiece of acupuncture on real significance. It is worthwhile to note that the book has a systematic and profound explanation on Bian-stone therapy, unearthed literature relics of acupuncture, the bronze figure or illustration of acupoint as well as special topics of Japan and Korea acupuncture history. Filled several gaps of the field, and explored some significant new paths of study, it laid the groundwork for the profound study and unscramble of traditional acupuncture theory as well as the investigation of the academic history, which is considered to have a profound and persistent influence. The careful sorting and profound digging of many distinguish thoughts and methods of Mr. MA Ji-xing in the study of acupuncture medical history has significant meaning in references and enlightenment of the future research on acupuncture medical history.

  8. Graft tendon slippage with metallic and bioabsorbable interference screws under cyclic load: a biomechanical study in a porcine model

    Directory of Open Access Journals (Sweden)

    Ari Digiácomo Ocampo Moré

    Full Text Available Introduction The rupture of the anterior cruciate ligament (ACL is the most common type of knee injury. Reconstructive surgery is the ‘gold standard’ treatment. During the immediate post-operative period, the fixation of the graft is entirely dependent on the ability of the grafted implant to be secured inside the bone tunnel under the cyclical loads associated with daily tasks. Poor fixation can lead to graft slippage, thus impairing the healing and integration of the graft. The aim of this study was to evaluate the biomechanical performance of tendon graft fixation devices with metallic and bioabsorbable interference screws. Methods Twenty ACL reconstructions were carried out in porcine tibias using deep flexor tendons to fix 9 × 20 mm metallic (n=10 and PLLA 70/30 bioabsorbable screws (n=10. To verify the ability of a construct to resist immediate postoperative (PO rehabilitation protocols for immediate load bearing, a cyclic loading test was applied with 50-250 N of tensile force at 1 Hz for 1000 cycles, and the displacement was measured at 10, 50, 100, 500 and 1000 load cycles to quantify the slippage of the graft during the test. After the cyclic loading test, a single-cycle load-to-failure test was applied. Results The slippage of the graft using metallic screws did not differ (P = 0.616 from that observed when using bioabsorbable screws. Conclusion The results obtained in this experiment indicate that metallic screws may promote a similar amount of graft slippage during low cyclic loading as bioabsorbable screws. Additionally, there was no difference in the biomechanical performance of these two types of screws during high failure loads.

  9. Load-bearing evaluation of spinal posterior column by measuring surface strain from lumbar pedicles. An in vitro study.

    Science.gov (United States)

    Sun, Peidong; Zhao, Weidong; Bi, Zhenyu; Wu, Changfu; Ouyang, Jun

    2012-01-01

    An understanding of the load transfer within spinal posterior column of lumbar spine is necessary to determine the influence of mechanical factors on potential mechanisms of the motion-sparing implant such as artificial intervertebral disc and the dynamic spine stabilization systems. In this study, a new method has been developed for evaluating the load bearing of spinal posterior column by the surface strain of spinal pedicle response to the loading of spinal segment. Six cadaveric lumbar spine segments were biomechanically evaluated between levels L1 and L5 in intact condition and the strain gauges were pasted to an inferior surface of L2 pedicles. Multidirectional flexibility testing used the Panjabi testing protocol; pure moments for the intact condition with overall spinal motion and unconstrained intact moments of ±8 Nm were used for flexion-extension and lateral bending testing. High correlation coefficient (0.967-0.998) indicated a good agreement between the load of spinal segment and the surface strain of pedicle in all loading directions. Principal compressive strain could be observed in flexion direction and tensile strain in extension direction, respectively. In conclusion, the new method seems to be effective for evaluating posterior spinal column loads using pedicles' surface strain data collected during biomechanical testing of spine segments.

  10. Someone to count on: social support as an effect modifier of viral load suppression in a prospective cohort study.

    Science.gov (United States)

    Friedman, M Reuel; Coulter, Robert W S; Silvestre, Anthony J; Stall, Ron; Teplin, Linda; Shoptaw, Steve; Surkan, Pamela J; Plankey, Michael W

    2017-04-01

    Though functional social support has been shown to serve as a protective factor for HIV viral load suppression in other populations, scant research has examined this relationship among men who have sex with men (MSM) in the United States. We assessed characteristics of social support, effects of social support on HIV viral load, and moderation by social support of the relationship between psychosocial indicators of a synergistic epidemic (syndemic) and HIV viral load. We analyzed longitudinal data from HIV-positive MSM using antiretroviral therapy who were enrolled in the Multicenter AIDS Cohort Study between 2002 and 2009 (n = 712). First, we conducted reliability assessments of a one-item social support measure. Then, we conducted a series of generalized longitudinal mixed models to assess our research questions. Moderation was assessed using an interaction term. A three-level (low/medium/high) social support variable demonstrated high reliability (intraclass correlation coefficients  = 0.72; 95% CI: 0.70, 0.75). Black and Hispanic MSM reported lower social support than their White counterparts (p social support (p social support (p social support levels were associated with greater viral load suppression and lower viral load means (p Social support moderated the relationships between syndemic and HIV viral load (p social support. Creating strengths-based interventions may also have particularly high impact among HIV-positive MSM with the highest psychosocial burdens.

  11. Study of the effect of humidity, particle hygroscopicity and size on the mass loading capacity of HEPA filters

    International Nuclear Information System (INIS)

    Gupta, A.

    1992-01-01

    The effect of humidity, particle hygroscopicity and size on the mass loading capacity of glass fiber HEPA filters has been studied. At humidifies above the deliquescent point, the pressure drop across the HEPA filter increased non-linearly with the areal loading density (mass collected/filtration area) of NaCl aerosol, thus significantly reducing the mass loading capacity of the filter compared to dry hygroscopic or non-hygroscopic particle mass loadings. The specific cake resistance, K 2 , has been computed for different test conditions and used as a measure of the mass loading capacity. K. was found to decrease with increasing humidity for the non-hygroscopic aluminum oxide particles and the hygroscopic NaCl particles (at humidities below the deliquescent point). It is postulated that an increase in humidity leads to the formation of a more open particulate cake which lowers the pressure drop for a given mass loading. A formula for predicting K 2 for lognormally distributed aerosols (parameters obtained from impactor data) is derived. The resistance factor, R, calculated using this formula was compared to the theoretical R calculated using the Rudnick-Happel expression. For the non-hygroscopic aluminum oxide the agreement was good but for the hygroscopic sodium chloride, due to large variation in the cake porosity estimates, the agreement was poor

  12. The use of simulated rainfall to study the discharge process and the influence factors of urban surface runoff pollution loads.

    Science.gov (United States)

    Qinqin, Li; Qiao, Chen; Jiancai, Deng; Weiping, Hu

    2015-01-01

    An understanding of the characteristics of pollutants on impervious surfaces is essential to estimate pollution loads and to design methods to minimize the impacts of pollutants on the environment. In this study, simulated rainfall equipment was constructed to investigate the pollutant discharge process and the influence factors of urban surface runoff (USR). The results indicated that concentrations of total suspended solids (TSS), total nitrogen (TN), total phosphorus (TP) and chemical oxygen demand (COD) appeared to be higher in the early period and then decreased gradually with rainfall duration until finally stabilized. The capacity and particle size of surface dust, rainfall intensity and urban surface slopes affected runoff pollution loads to a variable extent. The loads of TP, TN and COD showed a positive relationship with the surface dust capacity, whereas the maximum TSS load appeared when the surface dust was 0.0317 g·cm⁻². Smaller particle sizes (pollution carrying capacity of runoff, leading to higher pollution loads. Knowledge of the influence factors could assist in the management of USR pollution loads.

  13. Understanding how axial loads on the spine influence segmental biomechanics for idiopathic scoliosis patients: A magnetic resonance imaging study.

    Science.gov (United States)

    Little, J P; Pearcy, M J; Izatt, M T; Boom, K; Labrom, R D; Askin, G N; Adam, C J

    2016-02-01

    Segmental biomechanics of the scoliotic spine are important since the overall spinal deformity is comprised of the cumulative coronal and axial rotations of individual joints. This study investigates the coronal plane segmental biomechanics for adolescent idiopathic scoliosis patients in response to physiologically relevant axial compression. Individual spinal joint compliance in the coronal plane was measured for a series of 15 idiopathic scoliosis patients using axially loaded magnetic resonance imaging. Each patient was first imaged in the supine position with no axial load, and then again following application of an axial compressive load. Coronal plane disc wedge angles in the unloaded and loaded configurations were measured. Joint moments exerted by the axial compressive load were used to derive estimates of individual joint compliance. The mean standing major Cobb angle for this patient series was 46°. Mean intra-observer measurement error for endplate inclination was 1.6°. Following loading, initially highly wedged discs demonstrated a smaller change in wedge angle, than less wedged discs for certain spinal levels (+2,+1,-2 relative to the apex, (pbiomechanical data on in vivo spinal biomechanics of the scoliotic spine, for analysis of deformity progression and surgical planning. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Managing the space-time-load continuum in TMDL planning: a case study for understanding groundwaer loads through advanced mapping techniques

    Science.gov (United States)

    Phillip Harte; Marcel Belaval; Andrea Traviglia

    2016-01-01

    The lag time between groundwater recharge and discharge in a watershed and the potential groundwater load to streams is an important factor in forecasting responses to future land use practices. We call this concept managing the “space-time-load continuum.” It’s understood that in any given watershed, the response function (the load at any given time) will differ for...

  15. 从环境的历史到环境史——关于环境史研究的一种认识%From the history of the environment to environmental history: A personal understanding of environmental history studies

    Institute of Scientific and Technical Information of China (English)

    梅雪芹

    2007-01-01

    By and large, there are three kinds of research on environment: the history of environment as a field of natural history studies, the history of environment as within the scope of history of society studies, and environmental history as the study of the relationship between human and nature. The methodological perspective of the relationship between humanity and environmental distinguishes the third from the previous two. From thi sperspective, when we probe the mutual effects between human and nature, we will stress on their interactions. The new era and the realities of contemporary society foster the rise of environmental history, which has not only theoretical values but also practical significance.

  16. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study

    Directory of Open Access Journals (Sweden)

    Ismail Noor

    2012-08-01

    Full Text Available Abstract Background The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults. Methods A case–control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011. Comprehensive acne severity scale (CASS was used to determine acne severity. A questionnaire comprising items enquiring into the respondent’s family history and dietary patterns was distributed. Subjects were asked to record their food intake on two weekdays and one day on a weekend in a three day food diary. Anthropometric measurements including body weight, height and body fat percentage were taken. Acne severity was assessed by a dermatologist. Results Cases had a significantly higher dietary glycemic load (175 ± 35 compared to controls (122 ± 28 (p  0.05. Conclusions Glycemic load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris.

  17. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study.

    Science.gov (United States)

    Ismail, Noor Hasnani; Manaf, Zahara Abdul; Azizan, Noor Zalmy

    2012-08-16

    The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults. A case-control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011. Comprehensive acne severity scale (CASS) was used to determine acne severity. A questionnaire comprising items enquiring into the respondent's family history and dietary patterns was distributed. Subjects were asked to record their food intake on two weekdays and one day on a weekend in a three day food diary. Anthropometric measurements including body weight, height and body fat percentage were taken. Acne severity was assessed by a dermatologist. Cases had a significantly higher dietary glycemic load (175 ± 35) compared to controls (122 ± 28) (p  0.05). Glycemic load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris.

  18. Study of Pneumatic Servo Loading System in Double-Sided Polishing

    International Nuclear Information System (INIS)

    Qian, N; Ruan, J; Li, W

    2006-01-01

    The precise double-sided polishing process is one of the main methods to get the ultra-smooth surface of workpiece. In double-sided polishing machine, a loading system is required to be able to precisely control the load superimposed on the workpiece, while the polishing is being carried out. A pneumatic servo loading system is proposed for this purpose. In the pneumatic servo system, the servo valve, which acts both the electrical to mechanical converter and the power amplifier, has a substantial influence on the performance of the loading system. Therefore a specially designed pneumatic digital servo valve is applied in the control system. In this paper, the construction of the pneumatic servo loading system in double-sided polishing machine and control strategy associated with the digital servo valve are first addressed. The mathematical model of the system established and the hardware of the pneumatic servo system is designed. Finally, the experiments are carried out by measuring the practical load on the workpiece and the quality of the surface finish. It is demonstrated that the error rate of load is less than 5% and a super-smooth surface of silicon wafer with roughness Ra 0.401 nm can be obtained

  19. Natural history of severe atheromatous disease of the thoracic aorta: a transesophageal echocardiographic study.

    Science.gov (United States)

    Montgomery, D H; Ververis, J J; McGorisk, G; Frohwein, S; Martin, R P; Taylor, W R

    1996-01-01

    This study sought to prospectively observe the morphologic and clinical natural history of severe atherosclerotic disease of the thoracic aorta as defined by transesophageal echocardiography. Atherosclerosis of the thoracic aorta has been shown to be highly associated with risk for embolic events in transesophageal studies, but the natural history of the disease under clinical conditions has not been reported. During a 20-month period, 191 of 264 patients undergoing transesophageal echocardiography had adequate visualization of the aorta to allow atherosclerotic severity to be graded as follows: grade I = normal (44 patients); grade II = intimal thickening (52 patients); grade III = atheroma or = 5 mm (19 patients); grade V = mobile lesion (14 patients). All available patients with grades IV (8 patients) and V (10 patients) disease as well as a subgroup of 12 patients with grade III disease had follow-up transesophageal echocardiographic studies (mean [+/- SD] 11.7 +/- 0.9 months, range 6 to 22). Of 30 patients undergoing follow-up transesophageal echocardiographic studies, 20 (66%) had no change in atherosclerotic severity grade. Of the remaining 10 patients, atherosclerotic severity progressed one grade in 7 and decreased in 3 with resolved mobile lesions. Of 18 patients with grade IV or V disease of the aorta who underwent a follow-up study, 11 (61%) demonstrated formation of new mobile lesions. Of 10 patients with grade V disease on initial study who underwent follow-up study, 7 (70%) demonstrated resolution of a specific previously documented mobile lesion. However, seven patients (70%) with grade V disease also demonstrated development of a new mobile lesion. Of 33 patients with grade IV or V disease, 8 (24%) died during the study period, and 1 (3%) had a clinical embolic event. The presence of severe atherosclerotic disease of the thoracic aorta as defined by transesophageal echocardiography is associated with a high mortality rate. Although the morphologic

  20. The CCC2000 Birth Cohort Study of Register-Based Family History of Mental Disorders and Psychotic Experiences in Offspring

    DEFF Research Database (Denmark)

    Jeppesen, Pia; Tidselbak Larsen, Janne; Clemmensen, Lars

    2015-01-01

    in childhood was predicted by a family history of mental disorder with psychosis rather than a family history of nonpsychotic mental disorder and whether this association differed by severity of PE. The study examined data on 1632 children from a general population birth cohort assessed at age 11-12 years...... by use of a semistructured interview covering 22 psychotic symptoms. The Danish national registers were linked to describe the complete family history of hospital-based psychiatric diagnoses. Uni- and multivariable logistic regressions were used to test whether a family history of any mental disorder...... with psychosis, or of nonpsychotic mental disorder, vs no diagnoses was associated with increased risk of PE in offspring (hierarchical exposure variable). The occurrence of PE in offspring was significantly associated with a history of psychosis among the first-degree relatives (adjusted relative risk [RR] = 3...

  1. Preliminary Study on the Damping Effect of a Lateral Damping Buffer under a Debris Flow Load

    Directory of Open Access Journals (Sweden)

    Zheng Lu

    2017-02-01

    Full Text Available Simulating the impact of debris flows on structures and exploring the feasibility of applying energy dissipation devices or shock isolators to reduce the damage caused by debris flows can make great contribution to the design of disaster prevention structures. In this paper, we propose a new type of device, a lateral damping buffer, to reduce the vulnerability of building structures to debris flows. This lateral damping buffer has two mechanisms of damage mitigation: when debris flows impact on a building, it acts as a buffer, and when the structure vibrates due to the impact, it acts as a shock absorber, which can reduce the maximum acceleration response and subsequent vibration respectively. To study the effectiveness of such a lateral damping buffer, an impact test is conducted, which mainly involves a lateral damping buffer attached to a two-degree-of-freedom structure under a simulated debris flow load. To enable the numerical study, the equation of motion of the structure along with the lateral damping buffer is derived. A subsequent parametric study is performed to optimize the lateral damping buffer. Finally, a practical design procedure is also provided.

  2. Comparative anti-psoriatic efficacy studies of clobetasol loaded chitin nanogel and marketed cream.

    Science.gov (United States)

    Panonnummal, Rajitha; Jayakumar, R; Sabitha, M

    2017-01-01

    In the present study chitin nanogel loaded with anti-psoriatic drug clobetasol was developed (CLCNG) for its topical delivery in psoriasis. CLCNG had the particle size of 132±14nm, with gel like consistency, stability in refrigerator, having higher drug release properties at acidic pH. CLCNG exhibited significant toxicity towards HaCaT and THP-1cell lines by MTT assay. The uptake of nanogel by HaCaT cell lines was confirmed by fluorescent microscopy. CLCNG at 0.35mg/ml exhibited significant anti-inflammatory activity with an average of 65% and 70% inhibition in COX and LOX activities expressed in THP-1 cells. In vitro skin permeation studies revealed the increased transdermal flux with fragmented stratum corneum and loosened epidermal layers in CLCNG treated samples, compared with control drug solution. The in vivo anti-psoriatic studies done on imiquimod model confirmed the potential benefits of the nanogel for the topical delivery of clobetasol in psoriasis. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress

    Directory of Open Access Journals (Sweden)

    Millet Grégoire P

    2012-07-01

    Full Text Available Abstract Ultramarathons comprise any sporting event involving running longer than the traditional marathon length of 42.195 km (26.2 miles. Studies on ultramarathon participants can investigate the acute consequences of ultra-endurance exercise on inflammation and cardiovascular or renal consequences, as well as endocrine/energetic aspects, and examine the tissue recovery process over several days of extreme physical load. In a study published in BMC Medicine, Schütz et al. followed 44 ultramarathon runners over 4,487 km from South Italy to North Cape, Norway (the Trans Europe Foot Race 2009 and recorded daily sets of data from magnetic resonance imaging, psychometric, body composition and biological measurements. The findings will allow us to better understand the timecourse of degeneration/regeneration of some lower leg tissues such as knee joint cartilage, to differentiate running-induced from age-induced pathologies (for example, retropatelar arthritis and finally to assess the interindividual susceptibility to injuries. Moreover, it will also provide new information about the complex interplay between cerebral adaptations/alterations and hormonal influences resulting from endurance exercise and provide data on the dose-response relationship between exercise and brain structure/function. Overall, this study represents a unique attempt to investigate the limits of the adaptive response of human bodies. Please see related article: http://www.biomedcentral.com/1741-7015/10/78

  4. The Improvement of Students’ Leadership Ethic in Studying History by Using Baratayuda Audio Visual Media

    Directory of Open Access Journals (Sweden)

    Wendhy Rachmadhany

    2018-04-01

    Full Text Available The purpose of this research is to know the improvement of students’ leadership ethic in studying History after the implementation of Baratayuda Audio Visual Media. The population of this research is XI-Social Science-1 Class of SMAN 1 Pare, Kediri Regency, in academic year 2016/2017, consisted of 39 students. This Classroom Action Research (CAR is arranged by Pre-test, Cycle-1 and Cycle-2 which consisted by some steps, such like; planning, implementation, observation, and reflection. Collecting the data is by using questionnaire of leadership ethic, interview, and documentation. The method of data analysis in this research is descriptive analysis by comparing the improvement from one cycle to another. The result of the research is showing that: There is an improvement of leadership ethic in studying History after the implementation of Baratayuda Audio Visual media. It is shown by the results as follows; Pre-test indicates that the passing score is about 17, 95%. On Cycle-1 indicates 46, 1% and on Cycle-2 indicates a significant improvement about 71, 83%.

  5. The natural history of familial cerebral cavernomas: a retrospective MRI study of 40 patients

    International Nuclear Information System (INIS)

    Labauge, P.; Laberge, S.; Brunereau, L.; Levy, C.; Houtteville, J.P.

    2000-01-01

    Our objective was to determine the natural history and prognostic factors of familial forms of cerebral cavernous malformations (CCM). Cavernomas are one of the most common central nervous system vascular malformations. Familial CCM is increasingly diagnosed, but little is known about its natural history. In a national survey, we analysed clinical and MRI features of 173 patients from 57 unrelated French families. Of these 40 had undergone at least two clinical and MRI examinations. Occurrence of haemorrhage, new lesions, change in signal intensity and size of lesions have been studied by comparison between first and last MRI studies. The CCM were classified according to Zabramski et al. Mean follow-up was 3.2 years (range 0.5-6.5 years). We followed 232 cavernomas (mean 5.9 per patient, range 1-17). Serial MRI demonstrated changes in 28 patients (70 %). Bleeding occurred in 21 lesions (9.1 %) in 14 patients (35 %). The haemorrhagic risk was 2.5 % per lesion-year, higher in type I and brain-stem CCM. We saw 23 new lesions appear in 11 patients (27.5 %), with an incidence of 0.2 lesions per patient year. Signal change was observed in 11 patients (27.5 %), in 14 lesions (6 %), while 9 lesions (3.9 %) in 9 patients (22.5 %) changed significantly in size. (orig.)

  6. Toxoplasma gondii in women with bad obstetric history and infertility: a five-year study

    Directory of Open Access Journals (Sweden)

    Abida Malik

    2014-02-01

    Full Text Available Objective: To evaluate the role of Toxoplasma gondii in women with bad obstetric (BOH history and in women with primary and secondary infertility. Methods: This study was conducted in the Department of Microbiology, Jawaharlal Nehru Medical College and Hospital for a period of 5 years from January 2004 to December 2009. Quantitative determination of IgM antibodies to Toxoplasma gondii infection was done by IgM capture ELISA in patients with history of BOH or infertility. Results: Out of a total of 441 subjects included in the study, 417 (94.6% had a BOH and 24 (5.4% subjects had infertility. Toxoplasma was found to be more common in females with two or more abortions 52 (76.5%. Similarly in patients with infertility due to Toxoplasma, secondary infertility (66.7% was more common than primary infertility. About 40.3% patients with BOH and 20% patients with infertility had healthy live issues after treatment with spiramycin. Conclusions: Toxoplasmosis is thus, an easily treatable cause of abortions and infertility. All antenatal females and females with infertility should be screened for toxoplasmosis.

  7. Heavy smoking history interacts with chemoradiotherapy for esophageal cancer prognosis. A retrospective study

    International Nuclear Information System (INIS)

    Shitara, Kohei; Hatooka, Shunzo; Matsuo, Keitaro

    2010-01-01

    Smoking is a well-known risk factor for esophageal cancer. However, there are few reports that directly evaluate smoking as a prognostic factor for esophageal cancer. Moreover, scarce evidence is available on whether smoking interacts with major treatment modalities of esophageal cancer. In this study we retrospectively analyzed 364 patients with esophageal squamous cell cancer who were treated between 2001 and 2005 at our institution. Background characteristics, including smoking history, were analyzed as potential prognostic factors. Of the 363 patients, 76 patients (20.9%) were non-smokers or light smokers (non-heavy), whereas 287 patients (79.1%) were heavy smokers. The 5-year survival rate for non-heavy smokers and heavy smokers was 61.8% (95% confidence interval [CI]: 49.1-72.2) vs 44.6% (95% CI: 38.2-50.9), respectively. In a multivariate Cox model (adjusted for age, gender, performance status, alcohol consumption, histology, tumor length, International Union Against Cancer [UICC] stage, and treatment), the hazard ratio for heavy smokers in comparison with non-heavy smokers was 1.73 (95% CI: 1.12-2.68; P=0.013). When we stratified by treatment method, heavy smoking was significantly associated with poor survival only in patients treated by chemoradiotherapy (hazard ratio, 2.43; 95% CI: 1.38-4.27; P=0.002). More importantly, a statistically significant interaction between heavy smoking history and treatment modality was observed (P=0.041). Our results indicated that smoking history is strongly associated with poor prognosis in patients with esophageal cancer, especially those treated by chemoradiotherapy. Further investigation is warranted to explain this different prognosis. (author)

  8. History of Asthma From Childhood and Arterial Stiffness in Asymptomatic Young Adults: The Bogalusa Heart Study.

    Science.gov (United States)

    Sun, Dianjianyi; Li, Xiang; Heianza, Yoriko; Nisa, Hoirun; Shang, Xiaoyun; Rabito, Felicia; Kelly, Tanika; Harville, Emily; Li, Shengxu; He, Jiang; Bazzano, Lydia; Chen, Wei; Qi, Lu

    2018-05-01

    Asthma is related to various cardiovascular risk. Whether a history of asthma from childhood contributes to arterial stiffness in adulthood, a noninvasive surrogate for cardiovascular events, is unknown. Prospective analyses were performed among 1746 Bogalusa Heart Study participants aged 20 to 51 years with data on self-report asthma collected since childhood. Aorta-femoral pulse wave velocity (af-PWV, m/s) was repeatedly assessed among adults ≥aged 18 years. Generalized linear mixed models and generalized linear models were fitted for the repeated measurements of af-PWV and its changes between the last and the first measurements, respectively. After a median follow-up of 11.1 years, participants with a history of asthma from childhood had a higher af-PWV (6.78 versus 6.13; P =0.048) and a greater increase in af-PWV (8.99 versus 2.95; P =0.043) than those without asthma, adjusted for age, sex, race, smoking status, heart rate, body mass index, systolic blood pressure, lipids, and glycemia. In addition, we found significant interactions of asthma with body mass index and systolic blood pressure on af-PWV and its changes ( P for interaction The associations of asthma with af-PWV and its changes appeared to be stronger among participants who were overweight and obese (body mass index ≥25 kg/m 2 ) or with prehypertension and hypertension (systolic blood pressure ≥120 mm Hg) compared with those with a normal body mass index or systolic blood pressure. Our findings indicate that a history of asthma from childhood is associated with higher af-PWV and greater increases in af-PWV, and such associations are stronger among young adults who are overweight or with elevated blood pressure. © 2018 American Heart Association, Inc.

  9. Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis

    DEFF Research Database (Denmark)

    Vrenken, H; Jenkinson, M; Horsfield, M A

    2013-01-01

    resonance image analysis methods for assessing brain lesion load and atrophy, this paper makes recommendations to improve these measures for longitudinal studies of MS. Briefly, they are (1) images should be acquired using 3D pulse sequences, with near-isotropic spatial resolution and multiple image......Focal lesions and brain atrophy are the most extensively studied aspects of multiple sclerosis (MS), but the image acquisition and analysis techniques used can be further improved, especially those for studying within-patient changes of lesion load and atrophy longitudinally. Improved accuracy...

  10. The spaces of the margin. History of Sexuality and LGBTIQ studies from an interdisciplinary perspective

    Directory of Open Access Journals (Sweden)

    Elisabetta Bini

    2013-10-01

    Full Text Available The essay offers an overview of LGBTIQ studies, by analyzing several texts that have influenced the debate and research about the history of sexuality and LGBTIQ identities. The first part examines the forms of exchange and contamination between LGBTIQ and historical studies. The author argues that, since they emerged in the 1970s, LGBTIQ studies have aimed at challenging the specific forms of discrimination carried out against gays and lesbians, by highlighting the historical and social construction of sexuality and sexual identities. The essay focuses in particular on the importance of works by Michel Foucault, Adrienne Rich, Monique Wittig, Judith Butler, Teresa de Lauretis and American “women of color,” and their influence on historical research. The second part of the essay examines the photographs taken by several artists whose work focuses on sexual identities, such as Claude Cahun, Nan Goldin, Catherine Opie and Del LaGrace Volcano.

  11. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings

    International Nuclear Information System (INIS)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and panels. This volume contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.). Individual papers in this volume were abstracted and indexed for the database

  12. Scientific literacy: Role of natural history studies in constructing understanding of the nature of science

    Science.gov (United States)

    Lutz, Martha Victoria Rosett

    2002-01-01

    Scientific literacy is a central goal of science education. One purpose of this investigation was to reevaluate the definition of 'scientific literacy.' Another purpose was to develop and implement new curriculum involving natural history experiments with insects, with the goal of allowing students opportunities to construct an understanding of the nature of science, a crucial aspect of scientific literacy. This investigation was a qualitative case study. Methods of data collection included direct observations, analysis of sketches and written products created by students and class-room teachers, and analysis of audio tapes. Major findings include: (1) Scientific literacy is generally defined by lists of factual information which students are expected to master. When asked to evaluate their knowledge of selected items on a list published in a science education reform curriculum guide, 15 practicing scientists reported lack of familiarity or comprehension with many items, with the exception of items within their areas of specialization. (2) Genuine natural history experiments using insects can be incorporated into the existing school schedule and need not require any increase in the budget for science materials. (3) Students as young as first through third grade can learn the manual techniques and conceptual skills necessary for designing and conducting original natural history experiments, including manipulating the insects, making accurate sketches, developing test able hypotheses, recording data, and drawing conclusions from their data. Students were generally enthusiastic both about working with live insects and also conducting genuine science experiments. (4) Girls appear both positive and engaged with natural history activities and may be more likely than boys to follow through on designing, conducting, and reporting on independent experiments. The results imply that a valid definition of scientific literacy should be based on the ability to acquire scientific

  13. Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study.

    LENUS (Irish Health Repository)

    Macfarlane, T V

    2012-04-01

    The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.

  14. Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

    DEFF Research Database (Denmark)

    Ferrannini, E; Natali, A; Muscelli, E

    2011-01-01

    The natural history and physiological determinants of glucose intolerance in subjects living in Europe have not been investigated. The aim of this study was to increase our understanding of this area....

  15. Immediate Loading of Single Implants in the Anterior Maxilla: A 1-Year Prospective Clinical Study on 34 Patients

    Directory of Open Access Journals (Sweden)

    Miguel Stanley

    2017-01-01

    Full Text Available Purpose. To present the outcomes of immediately loaded single implants placed in the anterior maxilla. Methods. Over a 2-year period, all patients referred to a private clinic were considered for enrolment in this study. Inclusion criteria were single-tooth placement in postextraction sockets or healed sites of the anterior maxilla. All implants were immediately loaded and followed for a period of 1 year after the placement of definitive crowns. The outcome measures were implant stability, survival, and success. Results. 34 patients were selected and 43 tapered implants with a knife-edge thread design and a nanostructured, calcium-incorporated surface (Anyridge®, Megagen, Gyeongsang, Korea were installed. Two implants were not sufficiently stable at placement (ISQ < 60 and were considered failed for immediate loading; 41 implants had an ISQ ≥ 60 at placement and were immediately loaded. One year after the placement of definitive crowns, no implant failures were reported, for a survival rate of 100%. No biological complications were found, but 2 implants had their prosthetic abutments loosened: the implant success rate was 95.2%. Conclusions. In the present study on the immediate loading of single implants in the anterior maxilla, positive outcomes were reported, with high survival (100% and success (95.2% rates (the present study has been registered in the ISRCTN registry, a publicly available trial register recognized by WHO and ICMJE, with number ISRCTN12935478.

  16. A pilot study on quantification of training load: The use of HRV in training practice.

    Science.gov (United States)

    Saboul, Damien; Balducci, Pascal; Millet, Grégoire; Pialoux, Vincent; Hautier, Christophe

    2016-01-01

    Recent laboratory studies have suggested that heart rate variability (HRV) may be an appropriate criterion for training load (TL) quantification. The aim of this study was to validate a novel HRV index that may be used to assess TL in field conditions. Eleven well-trained long-distance male runners performed four exercises of different duration and intensity. TL was evaluated using Foster and Banister methods. In addition, HRV measurements were performed 5 minutes before exercise and 5 and 30 minutes after exercise. We calculated HRV index (TLHRV) based on the ratio between HRV decrease during exercise and HRV increase during recovery. HRV decrease during exercise was strongly correlated with exercise intensity (R = -0.70; p HRV changes during exercise and recovery phase are affected by both intensity and physiological impact of the exercise. Since the TLHRV formula takes into account the disturbance and the return to homeostatic balance induced by exercise, this new method provides an objective and rational TL index. However, some simplification of the protocol measurement could be envisaged for field use.

  17. Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALB/c Mice Model

    Directory of Open Access Journals (Sweden)

    Heshu Sulaiman Rahman

    2014-01-01

    Full Text Available Zerumbone- (ZER- loaded nanostructure lipid carrier (NLC (ZER-NLC prepared for its antileukemia effect in vitro was evaluated for its toxicological effects by observing changes in the liver, kidney, spleen, lung, heart, and brain tissues, serum biochemical parameters, total haemogram, and bone marrow stem cells. The acute toxicity study for ZER-NLC was conducted by orally treating BALB/c mice with a single dose with either water, olive oil, ZER, NLC, or ZER-NLC for 14 days. The animals were observed for clinical and behavioral abnormalities, toxicological symptoms, feed consumption, and gross appearance. The liver, kidney, heart, lung, spleen, and brain tissues were assessed histologically. Total haemogram was counted by hemocytometry and microhematocrit reader. Bone marrow examination in terms of cellular morphology was done by Wright staining with bone marrow smear. Furthermore, serum biochemical parameters were determined spectrophotometrically. Grossly all treated mice, their investigated tissues, serum biochemical parameters, total haemogram, and bone marrow were normal. At oral doses of 100 and 200 mg/kg ZER-NLC there was no sign of toxicity or mortality in BALB/c mice. This study suggests that the 50% lethal dose (LD50 of ZER-NLC is higher than 200 mg/kg, thus, safe by oral administration.

  18. Tool life prediction under multi-cycle loading conditions: A feasibility study

    Directory of Open Access Journals (Sweden)

    Yuan Xi

    2015-01-01

    Full Text Available In the present research, the friction and wear behaviour of a hard coating were studied by using ball-on-disc tests to simulate the wear process of the coated tools for sheet metal forming process. The evolution of the friction coefficient followed a typical dual-plateau pattern, i.e. at the initial stage of sliding, the friction coefficient was relatively low, followed by a sharp increase due to the breakdown of the coatings after a certain number of cyclic dynamic loadings. This phenomenon was caused by the interactive response between the friction and wear from a coating tribo-system, which has not been addressed so far by metal forming researchers, and constant friction coefficient values are normally used in the FE simulations to represent the complex tribological nature at the contact interfaces. Meanwhile, most of the current FE simulations are single cycle, whereas most sheet metal forming operations are conducted as multi-cycle. Therefore, a novel friction/wear interactive friction model was developed to, simultaneously, characterise the evolutions of friction coefficient and the remaining thickness of the coating layer, to enable the wear life of coated tooling to be predicted. The friction model was then implemented into the FE simulation of a sheet metal forming process for feasibility study.

  19. Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study.

    Science.gov (United States)

    Singh, Deependra; Saraf, Swarnlata; Dixit, Vinod Kumar; Saraf, Shailendra

    2008-04-01

    Gentamicin-Eudragit RS100 microspheres were prepared by modified double emulsion method. A 3(2) full factorial experiment was designed to study the effects of the composition of outer aqueous phase in terms of amount of glycerol (viscosity effect) and sodium chloride (osmotic pressure gradient effect) on the entrapment efficiency and % yield and microsphere size. The results of analysis of variance test for responses measured indicated that the test is significant (p>0.05). The contribution of sodium chloride concentration was found to be higher on entrapment efficiency and % yield, whereas glycerol produced significant effect on the mean diameter of microspheres. Microspheres demonstrated spherical particles in the size range of 33.24-60.43 microm. In vitro release profile of optimized formulation demonstrated sustained release for 24 h following Higuchi kinetics. Finally, drug bioactivity was found to remain intact after microencapsulation. Response surface graphs are presented to examine the effects of independent variables on the responses studied. Thus, by formulation design important parameters affecting formulation characteristics of gentamicin loaded Eudragit RS100 microspheres can be identified for controlled delivery with desirable characters in terms of maximum entrapment and yield.

  20. Pilot Study of a Plug Load Management System: Preparing for Sustainability Base

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA Ames Research Center’s Sustainability Base is a new 50,000 sq. ft. high-performance office building targeting a LEED Platinum rating. Plug loads are expected to...

  1. Building thermal loads: A case study for David Hellen Petta public secondary school

    CSIR Research Space (South Africa)

    Kumirai, T

    2013-03-01

    Full Text Available This chapter assesses the impact of appropriate passive interventions on building thermal loads. The passive interventions investigated are ceiling insulation, wall insulation, attic ventilation, natural ventilation and roof absorptance and also...

  2. The influences of load mass changing on inverted pendulum stability based on simulation study

    Science.gov (United States)

    Pangaribuan, Timbang; Nasruddin, M. N.; Marlianto, Eddy; Sigiro, Mula

    2017-09-01

    An inverted pendulum has nonlinear dynamic, so it is not easy to do in analysis to see its behavior. From many observations which have been made, there are two things that need to be added on the perfection of inverted pendulum. Firstly, when the pendulum has a large mass, and the second when the pendulum is given a load mass much larger than mass of the inverted pendulum. There are some question, first, how big the load mass can be given so that the movement of the inverted pendulum stay stable is. Second, how weight the changes and moves of load mass which can be given. For all the changes, it hopes the inverted pendulum is stay stable. Finally, the final result is still expected to be as stable, it must need conclude what kind of controller is capable of carrying such a mass burden, and how large the mass load limit can be given.

  3. Study on Stationarity of Random Load Spectrum Based on the Special Road

    Science.gov (United States)

    Yan, Huawen; Zhang, Weigong; Wang, Dong

    2017-09-01

    In the special road quality assessment method, there is a method using a wheel force sensor, the essence of this method is collecting the load spectrum of the car to reflect the quality of road. According to the definition of stochastic process, it is easy to find that the load spectrum is a stochastic process. However, the analysis method and application range of different random processes are very different, especially in engineering practice, which will directly affect the design and development of the experiment. Therefore, determining the type of a random process has important practical significance. Based on the analysis of the digital characteristics of road load spectrum, this paper determines that the road load spectrum in this experiment belongs to a stationary stochastic process, paving the way for the follow-up modeling and feature extraction of the special road.

  4. Human genetics studies in areas of high natural radiation. VII. Genetic load

    Energy Technology Data Exchange (ETDEWEB)

    Freire-Maia, A [Faculdade de Ciencias Medicas e Biologicas de Botucatu (Brazil). Departamento de Genetica

    1975-01-01

    Two methods to estimate the inbreeding load, employed in our analysis, are reviewed. Besides the total population, a sample constituted of individuals with no alien ancesters is also analyzed. The measurements by genetic load models show a clear effect of natural radioactivity (especially for abortions, pre-natal mortality, anomalies, and abnormalities in general). The results on stillbirths and post-natal and total mortalities are discussed and it is concluded that uncontrolled concomitant variables (if not chance alone) cause the differences.

  5. Case study: highly loaded MSE bridge supporting structure, Syncrude NMAPS conveyor overpasses

    Energy Technology Data Exchange (ETDEWEB)

    Scherger, B.; Brockbank, B. [Reinforced Earth Company Ltd., Edmonton, AB (Canada); Mimura, W. [Syncrude Canada Ltd., Edmonton, AB (Canada)

    2005-07-01

    A crusher and conveyor system was constructed at the Mildred Lake Oil Sands Mine near Fort McMurray, Alberta in order to facilitate ore delivery from Syncrude's North Mine. As part of this North Mine Auxiliary Production System (NMAPS), Syncrude Canada and their consultant Cosyn Technology identified the need for 3 overpasses over conveyors in the North Mine in order to provide unrestricted crossing over the operating conveyor system for the heavy hauler trucks and light vehicle mine traffic. The overpasses were designed to support the dead load of the granular fill and the live load of two loaded heavy hauler trucks, with a design load for each loaded hauler of 670 900 kg. This paper reviewed various aspects of the design from planning, structure selection, and overall stability and bearing capacity considerations. The different designs in the 3 new overpasses accommodated foundation and loading requirements. The designs ranged from the use of precast one-piece reinforced concrete arches, Mechanically Stabilized Earth (MSE) bridge abutment technology, and a combination of the two. The MSE retaining walls directly supported the bridge superstructure without the use of piles or other deep structural foundations. The design was challenging because of the significant vertical stresses transferred onto the wall. All 3 overpasses also used MSE walls for the supporting end wing walls. The main focus of this paper was on the heavily loaded MSE walls supporting the bridge abutment style overpasses. This structure has illustrated the capability of properly designed MSE wall structures with steel soil reinforcement and reinforced precast concrete face panels to successfully carry bridge footing pressure loadings up to 545 kPa. It was concluded that this case has good potential for use in future bridge projects in both the industrial and highway sectors. 2 refs., 7 figs.

  6. Experimental Study on the Structural Behavior of HSC Slab under out of plane load

    International Nuclear Information System (INIS)

    Ham, K. W.; Lee, K. J.; Park, D. S.

    2009-01-01

    HSC(Half Steel plate Concrete) Slab is a kind of SC(Steel plate Concrete) structure, so it has a similar advantage of SC structures (short construction period, lower cost and good quality control compared to RC). To apply HSC to the slab of containment building of NPP, several test with different test condition (shear span ratio, shear bar, loading type) were conducted to verify structural behavior of HSC slab structure under out of plane loading

  7. Study on Load-displacement Test of Rubber Pads of Coal Mine Roadway Constructed by Shield

    Science.gov (United States)

    Yang, Yue; Chen, Xiaoguo; Yang, Liyun

    2017-12-01

    Shield method construction of coal mine roadway is the future trend of the development of deep coal mining. The main shaft supporting is the segment. There is rubber pads between segment and segment. The performance of compression deformation of rubber pad is essential for the overall stability of lining. Through load test, displacement of the rubber pad under load, the thrust force law of the rubber pad deformation, and provide a theoretical basis for the stability analysis of coal mine tunnel shield construction.

  8. Towards a Decentred History: The Study of the Holodomor and Ukrainian Historiography

    Directory of Open Access Journals (Sweden)

    Olga Andriewsky

    2015-01-01

    Full Text Available This article reviews research on the Holodomor by historians of Ukraine since the late 1980s. It examines the dominant trends in historiography, the major findings, and the current state of the field. The field itself, it argues, has grown considerably and there now exists a critical body of scholarship on the subject. For the past two decades, this scholarship has largely been dominated by the debate about whether the Holodomor constitutes genocide. Much of the focus has been on illuminating the policies, methods, and intentions of the Soviet leadership and there have been notable advances in these areas of research. Social history on this topic, on the other hand, remains largely underdeveloped. Some historians of Ukraine have begun to study the Holodomor “from below” and to explore the larger social and cultural consequences of de-kulakization, collectivization, and the Terror-Famine. This approach is crucial, the author suggests, to understanding the exceptional nature of the era. In terms of patterns of migration, family structure, religious practices, social identity, status and ranking, and attitudes towards power, authority, and political participation, the Holodomor Era fundamentally changed the way Ukrainians lived. In this respect, it represents a turning point, as momentous as perhaps any in Ukrainian history.

  9. Feasibility study on the readiness, suitability and acceptance of M-Learning AR in learning History

    Science.gov (United States)

    Taharim, Nurwahida Faradila; Lokman, Anitawati Mohd; Hanesh, Amjad; Aziz, Azhar Abd

    2016-02-01

    There is no doubt that globalization and innovation in technology has led to the use of technology widespread in almost all sectors, including in the field of education. In recent years, the use of technology in the field of education has more widely and rapidly expand worldwide. Integration of technology in education always open to new opportunities where past studies have shown that technology enhances teaching and learning experience. There are various technologies that have been integrated into the various disciplines of education. Augmented Reality (AR) in mobile learning, which allows a combination of real and virtual worlds in a mobile device, is one of the latest technological potential and has been applied in the field of education. The aim of this research work is to mitigate the challenges faced by end users namely students and teachers of history class by means of creating Augmented Reality mobile application to increase the interest in both delivering and receiving the subject matter. The system consists a mobile platform for students to view the content, and a cloud-based engine to deliver the content based on recognized marker. The impact of such system has been tested on both students and teachers, where students showed interest in learning history, while teachers expressed interest to extend and adopt the system school wide.

  10. History-dependent dynamics in a generic model of ion channels - an analytic study

    Directory of Open Access Journals (Sweden)

    Daniel Soudry

    2010-04-01

    Full Text Available Recent experiments have demonstrated that the timescale of adaptation of single neurons and ion channel populations to stimuli slows down as the length of stimulation increases; in fact, no upper bound on temporal time-scales seems to exist in such systems. Furthermore, patch clamp experiments on single ion channels have hinted at the existence of large, mostly unobservable, inactivation state spaces within a single ion channel. This raises the question of the relation between this multitude of inactivation states and the observed behavior. In this work we propose a minimal model for ion channel dynamics which does not assume any specific structure of the inactivation state space. The model is simple enough to render an analytical study possible. This leads to a clear and concise explanation of the experimentally observed exponential history-dependent relaxation in sodium channels in a voltage clamp setting, and shows that their recovery rate from slow inactivation must be voltage dependent. Furthermore, we predict that history-dependent relaxation cannot be created by overly sparse spiking activity. While the model was created with ion channel populations in mind, its simplicity and genericalness render it a good starting point for modeling similar effects in other systems, and for scaling up to higher levels such as single neurons which are also known to exhibit multiple time scales.

  11. The 1941 villages census – an important source for studying local history

    Directory of Open Access Journals (Sweden)

    Sergiu Tabuncic

    2014-12-01

    Full Text Available The 1941 census is an important source for studying the history of the settlements from the present-time districts of Soldanesti and Rezina in the Republic of Moldova. In 1941, those localities were part of Bessarabia’s Orhei County. The materials of that census are stored at the National Archives of the Republic of Moldova, the fund No 2069, inventory 1, part 1, file 450-a. Villages Census 1941 – this is the title of the questionnaire used to collect data. The census was conducted under the auspices of the Central Institute of Statistics subordinate to the Council of Ministers of Romania. The census questionnaire contained 28 sections, each containing questions aimed to clarify the status of settlements in terms of administrative, social, economic, ethnographic, cultural, medical and religious aspects. Many questions pertained to the duration and continuity of the population’s residing in villages listed in the census and villages’ foundation years, to description of rural settlements, permanent and temporary dwellings. Also, the census results show some elements of relations between Romanians and Roma people. The 1941 census is the most significant and representative component of local history, substantially enriching the sources of this domain of research.

  12. Effects of caffeine, time of day and user history on study-related performance.

    Science.gov (United States)

    Mitchell, P J; Redman, J R

    1992-01-01

    The individual and interactive effects of caffeine, time of day and history of caffeine consumption on several study-related tasks were investigated in 25 subjects (6 males, 19 females). Performance was measured on short term memory (STM), mental arithmetic (MA), reading comprehension, serial search (SS) and verbal reasoning (VR). Subjects attended eight experimental sessions, at four times of day (0100, 0700, 1300 and 1900 hours), after ingesting caffeine (4 mg/kg) or placebo. Subjects were assigned to a low, moderate or high user group on the basis of a caffeine consumption questionnaire. Reading comprehension was affected by time of day, while caffeine improved performance on all mental speed-related tasks. High caffeine users performed more poorly than other groups on the verbal reasoning task. Several interactions between the three independent variables were observed on a number of tasks, supporting the contention that different processes underlying various types of cognitive performance are differentially, and often jointly, affected by caffeine, time of day and user history. Implications of caffeine usage on academic performance were discussed.

  13. Reinventing Entrepreneurial History

    DEFF Research Database (Denmark)

    Wadhwani, R. Daniel; Lubinski, Christina

    2017-01-01

    Research on entrepreneurship remains fragmented in business history. A lack of conceptual clarity inhibits comparisons between studies and dialogue among scholars. To address these issues, we propose to reinvent entrepreneurial history as a research field. We define “new entrepreneurial history...... and reconfiguring resources, and legitimizing novelty. The article elaborates on the historiography, premises, and potential contributions of new entrepreneurial history....

  14. A Study on Assessment Method of Traffic Load Effect of Bridge in Service

    Science.gov (United States)

    Ling, Pan; Dajian, Han

    2010-05-01

    Because of overloading usually occur in highway in China today, it is found that the traffic load and the load effects given by Specification for Inspection and Evaluation of Load-bearing Capacity of Highway Bridge[1] cannot be adequately estimated. Especially, the extreme values in a service period can not be predicted. In this paper, a model is first developed for a better estimation of the actual traffic flow, as well as the service load effect level of a bridge. Based on a five-day collection data of the vehicle samples passing through the exit of Guangyuan to Shahe of the North-Ring Highway in Guangzhou, The Qiaole Bridge of the highway is taken as an example to illustrate the assessment model. Then, a threshold model is applied to estimate the tail distribution of the maximum load effect of a fleet. And threshold point process is used to infer the maximum value distribution for prediction of the load effect level of the bridge in a future time period. Finally, a 0.95 quantile is obtained to compare with the result given by specification[1]. The results show that the assessment method proposed in this paper is valid and feasible.

  15. Cognitive Load and Cooperation

    DEFF Research Database (Denmark)

    Døssing, Felix Sebastian; Piovesan, Marco; Wengström, Erik Roland

    2017-01-01

    We study the effect of intuitive and reflective processes on cooperation using cognitive load. Compared with time constraint, which has been used in the previous literature, cognitive load is a more direct way to block reflective processes, and thus a more suitable way to study the link between...... intuition and cooperation. Using a repeated public goods game, we study the effect of different levels of cognitive load on contributions. We show that a higher cognitive load increases the initial level of cooperation. In particular, subjects are significantly less likely to fully free ride under high...... cognitive load....

  16. Use of 198 Au, with surface labelling, in the study of solid transport by bed load in large natural channels

    International Nuclear Information System (INIS)

    Nakahira, S.

    1987-01-01

    The present study aims to present a method of measuring the bed load transport using a radioisotope technique in large natural channels. This study describes the basic principles of radioisotope application in this field, emphasizing the use of 198 Au for surface labelling of a natural sediment. Moreover, it presents the theoretical aspects, critical analysis, recommendations and comments on the methodology proposed. (author)

  17. The influence of Young's modulus of loaded implants on bone remodeling: an experimental and numerical study in the goat knee.

    NARCIS (Netherlands)

    Stoppie, N.; Oosterwyck, H. Van; Jansen, J.A.; Wolke, J.G.C.; Wevers, M.; Naert, I.

    2009-01-01

    The aim of this study was to examine the influence of the Young's modulus of the implant material on the bone remodeling in a loaded condition. A combined animal experimental and computational study was set up. The animal experimental group comprised of 16 Saanen goats, each receiving one titanium

  18. Rewriting History.

    Science.gov (United States)

    Ramirez, Catherine Clark

    1994-01-01

    Suggests that the telling of vivid stories can help engage elementary students' emotions and increase the chances of fostering an interest in Texas history. Suggests that incorporating elements of the process approach to writing can merge with social studies objectives in creating a curriculum for wisdom. (RS)

  19. Loading Variables on Implant-Supported Distal-Extension Removable Partial Dentures: An In Vitro Pilot Study.

    Science.gov (United States)

    Hirata, Kiyotaka; Takahashi, Toshihito; Tomita, Akiko; Gonda, Tomoya; Maeda, Yoshinobu

    2016-01-01

    The aim of this study was to investigate strain on implants used for adjunctive support of distal extension removable partial dentures. An implant with strain gauges was used for testing purposes in two positions, parallel and inclined. Three loading scenarios--loading apparatus (LA), artificial teeth via cotton roll (CR), and artificial teeth (UT)--were studied and strains compared via the Kruskal-Wallis test (P=.05). Strain under CR was significantly larger than UT in parallel (P<.05). However, the opposite was observed in inclined. Strain in parallel was smallest for UT, whereas in inclined it was largest for CR.

  20. The effect of body position and axial load on spinal canal morphology: an MRI study of central spinal stenosis

    DEFF Research Database (Denmark)

    Madsen, Rasmus; Jensen, Tue Secher; Pope, Malcolm

    2007-01-01

    STUDY DESIGN: A method comparison study. OBJECTIVE: To investigate the effect of body position and axial load of the lumbar spine on disc height, lumbar lordosis, and dural sac cross-sectional area (DCSA). SUMMARY OF BACKGROUND DATA.: The effects of flexion and extension on spinal canal diameters...... with applied axial loading. Disc height, lumbar lordosis, and DCSA were measured and the different positions were compared. RESULTS: In section 1, the only significant difference between positions was a reduced lumbar lordosis during standing when compared with lying (P = 0.04), most probably a consequence...