Effects of lng Mutations on LngA Expression, Processing, and CS21 Assembly in Enterotoxigenic Escherichia coli E9034A

Science.gov (United States)

Saldaña-Ahuactzi, Zeus; Rodea, Gerardo E.; Cruz-Córdova, Ariadnna; Rodríguez-Ramírez, Viridiana; Espinosa-Mazariego, Karina; González-Montalvo, Martín A.; Ochoa, Sara A.; González-Pedrajo, Bertha; Eslava-Campos, Carlos A.; López-Villegas, Edgar O.; Hernández-Castro, Rigoberto; Arellano-Galindo, José; Patiño-López, Genaro; Xicohtencatl-Cortes, Juan

2016-01-01

Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity in children under 5 years of age in low- and middle-income countries and a leading cause of traveler's diarrhea worldwide. The ability of ETEC to colonize the intestinal epithelium is mediated by fimbrial adhesins, such as CS21 (Longus). This adhesin is a type IVb pilus involved in adherence to intestinal cells in vitro and bacterial self-aggregation. Fourteen open reading frames have been proposed to be involved in CS21 assembly, hitherto only the lngA and lngB genes, coding for the major (LngA) and minor (LngB) structural subunit, have been characterized. In this study, we investigated the role of the LngA, LngB, LngC, LngD, LngH, and LngP proteins in the assembly of CS21 in ETEC strain E9034A. The deletion of the lngA, lngB, lngC, lngD, lngH, or lngP genes, abolished CS21 assembly in ETEC strain E9034A and the adherence to HT-29 cells was reduced 90%, compared to wild-type strain. Subcellular localization prediction of CS21 proteins was similar to other well-known type IV pili homologs. We showed that LngP is the prepilin peptidase of LngA, and that ETEC strain E9034A has another peptidase capable of processing LngA, although with less efficiency. Additionally, we present immuno-electron microscopy images to show that the LngB protein could be localized at the tip of CS21. In conclusion, our results demonstrate that the LngA, LngB, LngC, LngD, LngH, and LngP proteins are essential for CS21 assembly, as well as for bacterial aggregation and adherence to HT-29 cells. PMID:27536289

The LNG Industry - 2005

International Nuclear Information System (INIS)

2006-04-01

First estimates for the marketed production of natural gas in 2005 show a rise of about 1.5 % over 2004. The share of LNG in the gas trade accounts for almost 21 % of the total. This annual report presents: 1 - LNG contracts and trade, 2 - Contracts concluded in 2005, 3 - LNG imports - Sources of imports - Quantities received in 2005 by the importing countries from the exporting countries, 4 - LNG tankers, 5 - 18 Ships delivered in 2005, 6 - Tanker distribution, 7 - Liquefaction plants, 8 - re-gasification plants, 9 - Long-term and medium-term contracts in force in 2005, 10 - Spot and short term quantities received in 2005 by the importing countries from the exporting countries, 11 - Sea transportation routes, 12 - Liquefaction plants (table), 13 - re-gasification plants (table), 14 - Delivery date of the LNG tankers

LNG -- Technology on the edge

International Nuclear Information System (INIS)

Alexander, C.B.

1995-01-01

With immense promise and many supporters, LNG as a vehicular fuel is still, a nascent industry. In about two years, an array of LNG engines should be commercially available, and infrastructure greatly expanded. These developments should reduce the present premium of LNG equipment, greatly improving industry economics. The most propitious sign for LNG-market developed lies in the natural gas industry's recently refined strategy for natural gas vehicles. The new strategy targets the right competitor--diesel, not gasoline. It also targets the right market for an emerging fuel--high-fuel-usage fleets made up of medium- and heavy-duty vehicles, often driven long distances. But problems persist in critical areas of development. These problems are related to the materials handling of LNG and the refueling of vehicles. The paper discusses the studies on LNG handling procedures, its performance benefits to high-fuel use vehicles, economic incentives for its use, tax disadvantages that are being fought, and LNG competition with ''clean'' diesel fuels

LIQUIFIED NATURAL GAS (LNG CARRIERS

Directory of Open Access Journals (Sweden)

Daniel Posavec

2010-12-01

Full Text Available Modern liquefied natural gas carriers are double-bottom ships classified according to the type of LNG tank. The tanks are specially designed to store natural gas cooled to -161°C, the boiling point of methane. Since LNG is highly flammable, special care must be taken when designing and operating the ship. The development of LNG carriers has begun in the middle of the twentieth century. LNG carrier storage space has gradually grown to the current maximum of 260000 m3. There are more than 300 LNG carriers currently in operation (the paper is published in Croatian.

The LNG Industry - 2004

International Nuclear Information System (INIS)

2005-04-01

First estimates for the marketed production of natural gas in 2004 show a rise of about 2 % over 2003. The share of LNG in the gas trade accounts for 21.9 % of the total. This annual report presents: 1 - LNG contracts and trade, 2 - Contracts concluded in 2004, 3 - LNG imports - Sources of imports - Quantities received in 2005 by the importing countries from the exporting countries, 4 - LNG tankers, 5 - 21 Ships delivered in 2004, 6 - Tanker distribution (at the end of 2004), 7 - Liquefaction plants, 8 - re-gasification plants, 9 - Long-term and medium-term contracts in force in 2004, 10 - Spot and short term quantities received in 2004 by the importing countries from the exporting countries, 11 - Sea transportation routes, 12 - Liquefaction plants (table), 13 - re-gasification plants (table), 14 - Delivery date of the LNG tankers

LNG - the challenge of growth

International Nuclear Information System (INIS)

Summers, G.G.

1992-01-01

LNG growth prospects - both in the Far East and Atlantic Basin - have never been better. Natural gas is responding strongly to the green momentum and to its clear competitive advantage in power generation. To meet growing demand, the major energy buyers are turning increasingly to large remote reserves of gas which often can only be delivered as LNG. But, the market will decide when and which LNG projects are developed - and the trigger will be price. LNG will compete head-on not only with low priced oil and coal but, in some markets, also with long-haul pipeline gas. This paper outlines regional demand and supply opportunities for LNG and then considers the challenges that the LNG industry must now tackle if it is to realistically expect a larger share of the world's energy market

Key issues considered at LNG 13

International Nuclear Information System (INIS)

Kidd, S.

2001-01-01

In the past few years, deregulation of the gas markets throughout the world has changed the way LNG projects can be brought into realisation. Gone are the days when large consortia of buyers could aggregate demand into quantities that made an LNG project economic. Today's market is typified by buyers requesting greater flexibility in volumes, shorter contract terms and reduced exposure to take-or-pay clauses. This means that the onus is on the producer to aggregate volume to make a large project viable, and to find flexible supply options as demand increases. As a result, there is an increasing ability to source LNG from excess capacity around the world, as has been demonstrated with the extended shutdown of the Arun LNG plant in Indonesia. Although some flexibility exists for the supply of LNG, it is unlikely that a world market where LNG is freely traded will develop. LNG projects will still require long-term contracts to ensure project financing. Furthermore, the 'LNG world' will remain separated into two regions the Atlantic and Asia-Pacific basins with only small amounts of 'spot' trading occurring between them. This is primarily due to the increased shipping costs associated with the global movement of LNG, and thus the ability to compete with closer sources of LNG and pipeline gas. Australia's position and its challenges in the LNG market is analysed

LNG plants in the US and abroad

International Nuclear Information System (INIS)

Blazek, C.F.; Biederman, R.T.

1992-01-01

The Institute of Gas Technology recently conducted a comprehensive survey of LNG production and storage facilities in North America. This survey was performed as part of IGT's LNG Observer newsletter which covers both domestic and international LNG news, reports on LNG related economics and statistics, and routinely conducts interviews with key industry leaders. In addition to providing consulting services to the LNG industry, IGT has cosponsored the International Conference on Liquefied Natural Gas for the part 20 years. The objective of this paper is to present a summary of our recent survey results as well as provide an overview of world LNG trade. This information is important in assessing the potential near term availability of LNG for transportation applications. The IGT LNG Survey appraised the capacity and current market activity of LNG peak shaving, satellite storage, and import receiving facilities in the United States and Canada. Information was requested from facilities on three main topics: liquefaction, storage, and regasification. Additional questions were posed regarding the year of operation, designer/contractor for liquefaction cycle and storage, source of LNG (for storage-only facilities), plans for expansion, and level of interest in providing LNG as a vehicle fuel. The IGT LNG Survey has to date received information on 56 LNG peak shaving facilities, 28 satellite storage facilities, and 4 LNG import receiving terminals

Potential local use of natural gas or LNG from Hammerfest LNG plant

International Nuclear Information System (INIS)

Neeraas, Bengt Olav

1999-01-01

A base-load LNG plant is planned to be built in Norway, near by the northern most city in the world, Hammerfest. Natural gas from the Snoehvit-field will be transported by pipeline to Melkoeya, a few kilometres from Hammerfest, where the liquefaction plant is planned to be located. SINTEF Energy Research has performed a study in co-operation with the local authorities on potentials for the use of LNG and natural gas locally in the Hammerfest region. Combined power and heat production by lean-burn gas engine, low temperature freezing of high quality products by use of LNG cold and drying of fish products are some of the identified fields for the use of natural gas and LNG. The establishment of an industrial area, with fish processing industry and a central freezing storage near by Hammerfest has been suggested. The gas may be transported locally either as LNG, by tank lorry or container, or as gas in a small pipeline, depending on distance, amount and the actual use. (author)

North America and Asia Pacific LNG markets

International Nuclear Information System (INIS)

Pirie, J.D.

1997-01-01

The liquefied natural gas (LNG) export opportunities in the Asia Pacific market were reviewed. Some of the differences that affect a North American LNG projects compared to more typical LNG projects were also outlined. The two main aspects of the LNG market in North America include the establishment of LNG import terminals on the east and southern coasts of the United States and the development of export oriented LNG projects. The Pac-Rim LNG project calls for initial delivery to South Korea of 4.0 MTPA by the end of 2000. A large LNG project has also been proposed for the year 2005 which would use Prudhoe Bay gas. Generally, in North America, there is little use for large scale LNG import projects because of the vast pipeline network that delivers gas reliably and at low cost anywhere in North America. However, LNG remains a good alternative for the Asia Pacific region because of the lack of a pipeline network. Also, Japan, Korea and Taiwan, the three main centers for LNG demand, have no domestic energy supplies and rely on imported energy sources. China is another major market opportunity for LNG. The Pac-Rim LNG project differs from others of its kind in that usually, an LNG project is based on the availability of large reservoirs of natural gas owned by state governments and involves production agreements with multi-national oil and gas companies. This scenario is simply not possible in Canada's deregulated environment. In contrast, the existence of upstream facilities, technical expertise, and low capital costs, hence reduced risks and time to develop an LNG project, gives Canada significant advantages. 3 tabs., 3 figs

LNG projects - nationally and internationally

International Nuclear Information System (INIS)

Graff, Oscar Fr.

2006-01-01

The presentation discusses various aspects of LNG projects nationally and internationally. The emphasis is on the future development of the natural gas markets, the competitiveness and economic requirements of the LNG production and transportation systems and the demands LNG projects will have to competence, technology, products and management

Safety in Liquefied Natural Gas (LNG) Operations

Energy Technology Data Exchange (ETDEWEB)

Buhrow, C. [Technische Univ. Bergakademie, Freiberg (Germany). Lehrstuhl Bergbau/Tiefbau; Niemann-Delius, C.; Okafor, E. [Technische Hochschule Aachen (Germany). Lehrstuhl und Inst. fuer Bergbaukunde 3

2005-07-01

Germany needs an LNG receiving terminal to import LNG and supplement expected future gas supply shortages. Enormous economic benefits also abound if Germany is to install an LNG receiving terminal. Jobs will be created for several hundred people. New tax revenues will be generated for state and local governments and this will further enhance the economic competitiveness of Germany. Additionally, it will provide Germany with a reliable source of clean-burning energy. Any proposed LNG receiving terminal should incorporate safety right from the start. These safety requirements will: ensure that certain public land uses, people, and structures outside the LNG facility boundaries are protected in the event of LNG fire, prevent vapour clouds associated with an LNG spill from reaching a property line that can be built upon, prevent severe burns resulting from thermal radiation, specify requirements for design, construction and use of LNG facilities and other equipments, and promote safe, secure and reliable LNG operations. The German future LNG business will not be complete without the evolution of both local and international standards that can apply to LNG operations. Currently existing European standards also appear inadequate. With an OHSAS 18001 management system integrated with other existing standards we can better control our LNG occupational health and safety risks, and improve performance in the process. Additionally, an OHSAS 18001 System will help future German LNG contractors and operators safeguard their most important assets - their employees. (orig.)

LIQUIFIED NATURAL GAS (LNG) CARRIERS

OpenAIRE

Daniel Posavec; Katarina Simon; Matija Malnar

2010-01-01

Modern liquefied natural gas carriers are double-bottom ships classified according to the type of LNG tank. The tanks are specially designed to store natural gas cooled to -161°C, the boiling point of methane. Since LNG is highly flammable, special care must be taken when designing and operating the ship. The development of LNG carriers has begun in the middle of the twentieth century. LNG carrier storage space has gradually grown to the current maximum of 260000 m3. There are more than 300 L...

The LNG Industry - 2010

International Nuclear Information System (INIS)

2011-04-01

In 2010, global energy demand has recovered. Estimates for World Natural Gas consumption show a 7.3% increase compared with 2009 thanks to the economic rally and the cold winter conditions in Western countries. Due to the decline of indigenous productions in mature markets and to the development of new gas markets, international gas flows continued to expand, and total international gas trade increased by 10.9% compared with 2009. In this context, LNG flows recorded the largest growth with a 21% increase in 2010, the operational start-up of new liquefaction capacity in Qatar being the primary reason. By comparison, pipeline trade increased by 7%. This annual report presents: 1 - LNG contracts and trade, 2 - Contracts concluded in 2010, 3 - LNG imports - Sources of imports - Quantities received in 2010, 4 - LNG tankers, 5 - Ships delivered, 6 - Tanker distribution, 7 - Liquefaction plants, 8 - re-gasification plants, 9 - Contracts in force in 2010, 10 - Spot and short term quantities received in 2010, 11 - Sea transportation routes, 12 - Liquefaction plants (table), 13 - re-gasification plants (table), 14 - Delivery date of the LNG tankers

LNG - emergency control

Energy Technology Data Exchange (ETDEWEB)

Berardinelli, Ricardo Porto; Correa, Kleber Macedo; Moura Filho, Nelson Barboza de; Fernandez, Carlos Antonio [TRANSPETRO, Rio de Janeiro, RJ (Brazil); Matos, Jose Eduardo Nogueira de [PETROBRAS, Rio de Janeiro, RJ (Brazil)

2009-07-01

The operation of liquefied natural gas (LNG) is pioneering within the PETROBRAS System. PETROBRAS Transporte - TRANSPETRO is going to operate two flexible LNG terminals, located in Ceara and Rio de Janeiro. In accordance with the Corporate Health, Safety and Environmental (HSE) Directive - Training, Education and Awareness, PETROBRAS Transporte S.A. - TRANSPETRO has prepared an action plan with the objective of ensuring the operational safety of the undertaking. Among other actions a training program for the emergency control of LNG will be inserted into the timetable. The above mentioned training program was held over a period of 20 hours, and was divided between theory and practice. In the theoretical part, the characteristics of the product, the history of accidents and the emergency response procedures were covered. In the practical part, 3000 gallons of LNG were utilized where the behavior of the product could be confirmed following a confined leak, thereby verifying the efficacy of the emergency control resources. The teaching process of the course was developed in the company through the preparation of specific procedures, emergency plans and the formation of internal instructors. (author)

Power and LPG production with LNG import

International Nuclear Information System (INIS)

Mak, J.Y.

2004-01-01

When used in power cogeneration, Liquefied Natural Gas (LNG) is both energy efficient and can eliminate seawater or fuel gas consumption as well as the associated environmental impacts of conventional regasification processes. However, some liquefied natural gas (LNG) sources have heating values higher than current North American natural gas pipelines can allow for. LNG from these cannot be injected into gas pipelines without several heating control processing steps. This paper outlines two new technologies developed to address this issue. The first is a power cogeneration process using LNG as a heat sink. The second technology involves a fractionation process removing Liquid Propane Gas (LPG) components from imported LNG, thereby controlling heat value. Both technologies are applicable in grassroots installations as well as being suitable for retrofitting to existing LNG regasification for power generation and LPG production. It was concluded that power cogeneration with a mixed fluid power cycle recovered a significant portion of energy in LNG liquefaction plants. Additionally, it was also possible to fractionate high quality LPG from LNG at a low cost, with the residue being further re-condensed and re-utilized for power generation. It was also concluded that the LNG fractionation process would add flexibility to the LNG receiving terminals, allowing the import of lower quality LNG to North America, while also generating additional revenues from LPG production. 3 refs., 5 tabs., 6 figs

LNG links remote supplies and markets

International Nuclear Information System (INIS)

Avidan, A.A.; Gardner, R.E.; Nelson, D.; Borrelli, E.N.; Rethore, T.J.

1997-01-01

Liquefied natural gas (LNG) has established a niche for itself by matching remote gas supplies to markets that both lacked indigenous gas reserves and felt threatened in the aftermath of the energy crises of the 1970s and 1980s. It has provided a cost-effective energy source for these markets, while also offering an environmentally friendly fuel long before that was fashionable. The introduction of natural-gas use via LNG in the early years (mostly into France and Japan) has also allowed LNG to play a major role in developing gas infrastructure. Today, natural gas, often supplied as LNG, is particularly well-suited for use in the combined cycle technology used in independent power generation projects (IPPs). Today, LNG players cannot simply focus on monetizing gas resources. Instead, they must adapt their projects to meet the needs of changing markets. The impact of these changes on the LNG industry has been felt throughout the value chain from finding and producing gas, gas treatment, liquefaction, transport as a liquid, receiving terminals and regasification, and finally, to consumption by power producers, industrial users, and households. These factors have influenced the evolution of the LNG industry and have implications for the future of LNG, particularly in the context of worldwide natural gas

Panel discussion: LNG's future in Asia

International Nuclear Information System (INIS)

Ohashi, Tadahiko

1992-01-01

The panelists convened to: (1) identify and evaluate the role which LNG is likely to play in the changing energy scene; (2) to examine the future supply and demand structure of the LNG trade; (3) to discover the key obstacles to continued growth in LNG trade; and (4) to find solutions to these problems. The panelists identified and outlined growing opportunities for LNG utilization in Asia during the next two decades. They shared the opinion that the structure of the supply and demand balance for LNG in Asia will shift during the next decade, providing considerable room for new projects. The key obstacles to continued growth in LNG trade are the lack of: long-distance transmission networks and an efficient competitive market pricing mechanism for LNG in the Asian region. The major importers in the region are keen on developing a range of new long-term supply alternatives, not simply within the Asia-Pacific region, but also from a wider perspective. These alternatives include: financing the expansion of production from existing facilities, development of new fields, and construction of long-distance pipelines

Global LNG - characteristics, clients and contracts

International Nuclear Information System (INIS)

Bauquis, P.R.

1997-01-01

Total's liquefied natural gas (LNG) holdings were described. Other topics discussed included an overview of gas consumption and internationally traded gas in 1995, a primer on the history of LNG, Japan's average import prices in 1996, Europe's border gas prices and consumption in 1995, Canada/US regional price differences in 1995 and 1996, and world gas markets and prices in 1996. The projected LNG supply and demand in Europe and Asia , especially in Japan, China and India, was also discussed. General concepts of LNG pricing, the general structure of a gas sales contract, and the different categories of LNG contracts were also reviewed. 24 figs

The Malaysia LNG experience

International Nuclear Information System (INIS)

Muhammed, M.

1991-01-01

This paper summarizes the nature of the LNG trade, the essential components and characteristics of an LNG project, and relates the Malaysia LNG experience to project realization with some emphasis on the financial aspects of the project. Twelve offshore lending institutions were involved in the total project loop providing U.S. dollar equivalents of 4.0 billions with interest rates ranging from 5% to 8%. The total project was completed on schedule and within budget except for the ships which got caught in the political development of the Malaysian petroleum industry at that time

77 FR 73627 - 2012 LNG Export Study

Science.gov (United States)

2012-12-11

... DEPARTMENT OF ENERGY 2012 LNG Export Study AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of availability of 2012 LNG Export Study and request for comments. Freeport LNG Expansion, L.P. [FE Docket No. 10-161-LNG] and FLNG Liquefaction, LLC. Lake Charles Exports, LLC.... [FE Docket...

Arctic Islands LNG

Energy Technology Data Exchange (ETDEWEB)

Hindle, W.

1977-01-01

Trans-Canada Pipe Lines Ltd. made a feasibility study of transporting LNG from the High Arctic Islands to a St. Lawrence River Terminal by means of a specially designed and built 125,000 cu m or 165,000 cu m icebreaking LNG tanker. Studies were made of the climatology and of ice conditions, using available statistical data as well as direct surveys in 1974, 1975, and 1976. For on-schedule and unimpeded (unescorted) passage of the LNG carriers at all times of the year, special navigation and communications systems can be made available. Available icebreaking experience, charting for the proposed tanker routes, and tide tables for the Canadian Arctic were surveyed. Preliminary design of a proposed Arctic LNG icebreaker tanker, including containment system, reliquefaction of boiloff, speed, power, number of trips for 345 day/yr operation, and liquefaction and regasification facilities are discussed. The use of a minimum of three Arctic Class 10 ships would enable delivery of volumes of natural gas averaging 11.3 million cu m/day over a period of a year to Canadian markets. The concept appears to be technically feasible with existing basic technology.

The LNG Industry in 2006

International Nuclear Information System (INIS)

Anon.

2007-01-01

Estimates for the marketed production of natural gas in 2006 show a rise of about 3% over 2005. The share of LNG in the gas trade accounts for 23% of the total. In 2006, the international trade in liquid form accounted for 348.4 10 6 m 3 or almost 159 10 6 t. It rose by 38.4 10 6 m 3 , or 12.4%, the highest growth rate ever recorded over the last decade. As to imports: - Japan remained by far the world's largest LNG importer with 136 10 6 m 3 , or 39% of all imports, followed by Korea with 55.3 10 6 m 3 (15.9%) and Spain with 41.6 10 6 m 3 (12.0%), markedly higher than the U.S.A. ranking fourth with 26 10 6 m 3 (7.5%). Seventeen countries were involved in LNG imports with the addition of China and Mexico in 2006. - The growth rate of European imports remained stable at 21%, above the global growth rate of 12.4%, resulting in a market share for Europe of 27.4% and demonstrating the dynamism of this region in the LNG trade. With a 12% market share in worldwide trade, Spain maintained its position as Europe's largest LNG market. - After substantial increases during the early part of this decade, the US market suffered most from the shortage in LNG production and price arbitration prompted some shippers to divert spot LNG away from the US market. Imports for the Americas as a whole still decreased by 3.2% and their global market share fell to 8.5%. - The Asian market kept on growing steadily by 11.4% with imports to the region rising from 200.6 10 6 m 3 to 223.4 10 6 m 3 or an increase of 22.8 10 6 m 3 , mainly due to the continued rise of Indian imports with a 3.9% market share, and the emergence of China on the LNG scene. Japanese imports steadily rose to 136 10 6 m 3 . Korea also enjoyed a significant growth by 13.5% to 55.3 10 6 m 3 while Taiwan's imports grew by 8.5% to 17 10 6 m 3 . As to sources of imports: Indonesia lost its leading position and Qatar became the world's largest LNG producer with 15.5% of all exports. Indonesia ranked second with 13.9%, Malaysia

46 CFR 154.703 - Methane (LNG).

Science.gov (United States)

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Methane (LNG). 154.703 Section 154.703 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS FOR... and Temperature Control § 154.703 Methane (LNG). Unless a cargo tank carrying methane (LNG) can...

The LNG Industry - 2013

International Nuclear Information System (INIS)

Dispenza, Domenico

2014-04-01

In 2013 the LNG markets remained extremely tight due to the demand pull from nuclear closures in Japan and South Korea and the difficulties to ramp-up production of new facilities in Angola and Algeria, bringing LNG price levels in the Far East to record highs in the first quarter. In addition to Cheniere's Sabine Pass, three new liquefaction projects received full approvals in the U.S.A. last year, confirming the country's path to become the world's third largest LNG exporter by the end of the decade. Cameron joined their ranks in early 2014 so that at the time of this writing, a total 62.5 Mt/y of capacity have been approved to export to non-FTA countries by the Department of Energy, already impacting the LNG industry, if not in physical volume then in contracting strategy. 2013 could be considered a transition year. LNG traded volumes as a whole remained at the same level as in 2012, but new trade patterns seem to emerge. The past year may have seen a slowdown in the number of FIDs, counting only one greenfield (Yamal LNG) and two expansion projects, but not in capacity increase with a respectable 29 Mt/y committed in total. Demand remained strong in Asia, mainly in China and South Korea. In Japan, imports continued to increase, although more moderately in a response to high prices and the yen devaluation, shifting the energy mix towards other sources of energy. Demand also increased in South America, strongly related to weather factors. Europe remained the swing provider to the world's LNG market. In a context of depressed local demand and with the utilization rate of the re-gasification terminals in their region at a historical low, European players continued with innovative transactions in search for business (such as re-loadings, two-port loadings, ship-to-ship transfers) while developing new markets for LNG as a transportation fuel. Three new countries joined the ranks of LNG importers in 2013: Israel, Malaysia, and Singapore. Total

LNG's renaissance in the U.S. -- why now?

International Nuclear Information System (INIS)

Moore, J.

2000-01-01

The present state and future prospects for the U.S. liquefied natural gas industry are reviewed in light of expanding opportunities for LNG export worldwide. An update on new tanker ships to transport LNG by both exporters and importers and on developments at US LNG facilities at Everett, MA, Cove Point, MD, Elba Island, GA, and at Lake Charles, LA, is provided, along with an assessment of East Coast supply sources and demand forecast. The prediction is that worldwide supply/demand for LNG will tighten, that US prices will be strong enough to support LNG, that proposed expansion of LNG liquefaction facilities in the Atlantic Basin will fill US import facilities, and that East Coast demand growth will absorb growth in LNG imports

Financial structure of Korea Gas Corporation's LNG projects

International Nuclear Information System (INIS)

Jeongsoo Ko

1991-01-01

When an Indonesian LNG tanker arrived in Korea for the first time in October 1986, Korea became the seventh LNG-consuming nation in the world. The imported LNG has contributed greatly to solving pollution problems and ensuring a stable supply of energy to Korea through the diversification of energy sources. So far, the LNG supply has been confined to the Metropolitan area. The Korea Gas Corporation now plans to expand the LNG supply to cover the entire nation. This paper introduces the experience and future plan of Korea's LNG projects with a special reference to their financial structure

LNG plant combined with power plant

Energy Technology Data Exchange (ETDEWEB)

Aoki, I; Kikkawa, Y [Chiyoda Chemical Engineering and Construction Co. Ltd., Tokyo (Japan)

1997-06-01

The LNG plant consumers a lot of power of natural gas cooling and liquefaction. In some LNG plant location, a rapid growth of electric power demand is expected due to the modernization of area and/or the country. The electric power demand will have a peak in day time and low consumption in night time, while the power demand of the LNG plant is almost constant due to its nature. Combining the LNG plant with power plant will contribute an improvement the thermal efficiency of the power plant by keeping higher average load of the power plant, which will lead to a reduction of electrical power generation cost. The sweet fuel gas to the power plant can be extracted from the LNG plant, which will be favorable from view point of clean air of the area. (Author). 5 figs.

LNG plant combined with power plant

International Nuclear Information System (INIS)

Aoki, I.; Kikkawa, Y.

1997-01-01

The LNG plant consumers a lot of power of natural gas cooling and liquefaction. In some LNG plant location, a rapid growth of electric power demand is expected due to the modernization of area and/or the country. The electric power demand will have a peak in day time and low consumption in night time, while the power demand of the LNG plant is almost constant due to its nature. Combining the LNG plant with power plant will contribute an improvement the thermal efficiency of the power plant by keeping higher average load of the power plant, which will lead to a reduction of electrical power generation cost. The sweet fuel gas to the power plant can be extracted from the LNG plant, which will be favorable from view point of clean air of the area. (Author). 5 figs

LNG market: future clouded by uncertainty

Energy Technology Data Exchange (ETDEWEB)

Segal, J

1979-12-01

The emergence of a US national energy policy playing down the role of LNG, along with a growing trend toward unfavorable production and pricing policies by LNG-exporting nations, will limit international LNG trade to about 9-10.5 billion CF/day by 1985, instead of the 13.4-15 billion CF predicted previously. In the US, LNG now stands fifth in priority as a baseload supply source, following conventional Lower 48 supplies, Alaskan pipeline gas, imports from Canada and Mexico, and domestic synthetic gas. Despite this federal policy and the adjoined decision to apply incremental pricing to future LNG imports, two new projects will soon come on-stream in the US: one to receive 450 million CF/day of Algerian gas at Lake Charles, La., and another to receive 539 million CF/day from Indonesia and 431 million CF/day from Alaska at a terminal in California.

The Japanese approach to financing LNG projects

International Nuclear Information System (INIS)

Aoki, Wataru

1995-01-01

The Japanese approach approach to financing LNG project has been what could be called a combined purchase and finance system which has been arranged mainly at the initiative of japan's Sogo Shosh (general trading companies) with the support of japanese governmental financial agencies and a purchase commitment from japanese utilities. In the QATARGAS project, despite it being the first greenfield LNG project in decade since North West Shelf Australia LNG project, financing for the LNG plant phase has been successfully arranged through Japanese financing. The structuring of the financial facilities for the QATARGAS project seems to have lessons for future development of the next generation of greenfield LNG projects. Discharge of the parties' liability, proper sharing of the risk burden and reconfirmation of the spirit of mutual understanding and trust among the parties concerned are key factors for the success of any new LNG project in the future. (Author)

Is LNG the way ahead for natural gas?

International Nuclear Information System (INIS)

Chabrelie, M.F.; Dhellemmes, J.; Hosanski, J.M.; Goy, A.

2004-01-01

The topic of the last 2004 meeting of the French gas association (AFG) was the liquefied natural gas (LNG) which takes a growing up share in the international gas trade. The number of liquefaction plants and re-gasification terminals have increased and liquefied natural gas tanker fleets grown to match the development of world trade. The three major French players in the LNG field are Total, which produces gas and LNG in several countries, Gaz de France (GdF) which buys in a significant quantity of LNG, and GTT which provides engineering services for shipping. To get a better inside view of the LNG question, four specialists were invited to the last AFG meeting. This paper summarizes their opinion about the following points: the world potential LNG offer and the growing up capacities (LNG development, markets, supply and demand, companies strategy), the shipping by tanker ships (membrane insulation technology, fleet uses and perspectives), convergence of LNG markets and the role of Middle-East (shipping, increase of Middle-East LNG share in the world market, major stakes for the international companies), and the constraints and opportunities of re-gasification (terminals optimization, competition for re-gasification, terminals setting up problems, technical solutions). A summary of the questions and answers with the public concludes the article. (J.S.)

LNG Market: Developments in 2014 and 2015 Outlook. Enerdata Gas/LNG and Power Consulting - January 2015

International Nuclear Information System (INIS)

2015-01-01

Enerdata power and gas expert held a webinar on the important developments happened in the LNG market in 2014 and provided insight on the LNG market outlook for 2015. 2015 is the year of uncertainty for the LNG industry. We will continue to experience low LNG prices driven by temporary liquefaction over capacity. The 2015 low prices environment will continue to support domestic gas price reforms in countries such as India, China, Malaysia and Indonesia. National economies of high LNG consumers such as Japan, Korea and Taiwan will benefit from low energy cost. Import terminal operators will see their utilization rates drop at concerning levels where the balance between operating cost and revenue starts to move on the red zone. Project developers will continue to delay their FID until they can see the light out of the tunnel. Those negotiating long term contracts have the big dilemma of shall it be oil-linked or not oil-linked. Never as before the importance to have a good insight of the future will differentiate losers from winners

Algeria's response to future LNG needs: The revamping of its LNG plants

International Nuclear Information System (INIS)

Bendani, A.; Rekkab, O.

1992-01-01

Since the beginning of the sixties, Algeria decided to participate in the international commerce of gas through its LNG. Four plants have thus been built and started in 1964, 1972, 1978 and 1981. Following the decrease in world LNG demand in the eighties, these plants built to supply 30 billion M 3 have not been operated at their full capacities. As a result, the plant equipment has suffered from this situation of partial operation (excessive shutdowns and startups). In order for SONATRACH to participate as it wishes in the expected increase in world LNG demand, two alternatives are possible to achieve this objective: Rehabilitate existing plants to enable them to operate safety and continuously to their full capacities or, build new plants. It is the first alternative that has been selected and the previous plant constructors have been selected for their renovation

LNG and LPG total involvement of Pullman Kellogg

Energy Technology Data Exchange (ETDEWEB)

1978-10-01

A discussion of Pullman Kellogg activity covers a new LNG terminal in Belgium; construction of LNG 2 for Sonatrach in Algeria; an LPG recovery system in Kuwait; the Trunkline Gas Co. LNG project at Lake Charles, La.; and the Cove Point, Md., facility for Columbia Gas System Inc. and Consolidated Natural Gas Co., which will be capable of mooring two 750,000 bbl LNG tankers simultaneously.

A basic study on underground storage of LNG

Energy Technology Data Exchange (ETDEWEB)

Kim, Min-Kyu; Lee, Kyung-Han; Kang, Sun-Duck [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

1999-12-01

In 1997, import of LNG was 11,378 thousand of about 2.3 billion US dollars. The demand of LNG(Liquefied Natural Gas) in Korea has been increased since 1987 with the rate of 20% annually. It is also estimated that this trend will be continued until 2010. Long-term estimation says that demand will increase with 9.1% and total demand of 2010 will be 23 million ton that is four times larger than that of 1994. Bases of unloading and store of LNG is necessary to complete the network of LNG distribution system to cover all of the country from import to final supply terminal at home. The construction plan of LNG bases with 49 tanks was published and is going on now at three bases, Pyungtaek, Incheon and Tongyoung. The total cost for this construction will be over 5,400 billion Won. All the LNG tanks are planned to build on the surface. The construction of LNG tanks on the surfaces is conventional but it damage the surface green area and is very vulnerable on safety, especially in Korea Peninsula with potentially unstable of military confrontation. And Korea is so small and limited in available land that it is not easy to find proper places for construction of more LNG tanks on surface. Underground LNG stores in rock will be a good alternative for tanks on surface in the view points of environmental and safety. It is also reported that it can be cheaper than that of on surfaces. It is well known that bed rocks in Korea is good to build underground structure like LNG stores. This report is basic research to seek for the possibility of LNG store construction in underground rocks. The important two questions on it is that whether it is possible technically and economically or not. The technical focus in this report is the stability of underground cavern for storage of LNG, energy conservation in operation, tightness against leakage of stored gas to surface and safety. Some statistic on LNG in Korea is given for this study with its future. (author). 25 refs., 36 tabs., 88 figs.

The sustainability of LNG evaporation

NARCIS (Netherlands)

Stougie, L.; Van der Kooi, H.J.

2011-01-01

Numerous LNG (Liquefied Natural Gas) import terminals are under construction to fulfil the growing demand for energy carriers. After storage in tanks, the LNG needs to be heated and evaporated, also called ‘regasified’, to the natural gas needed in households and industry. Several options exist for

Asia-Pacific focus of coming LNG trade boom

International Nuclear Information System (INIS)

Anon.

1992-01-01

This paper reports that the Asia-Pacific region remains the centerpiece of a booming world trade in liquefied natural gas. Biggest growth in LNG demand is expected from some of the region's strongest economies such as Japan, South Korea, and Taiwan, Key LNG exporters such as Brunei, Malaysia, and Indonesia are scrambling to implement projects to meet that expected demand growth. Uncertainties cloud the outlook for Far East LNG trade, Australia, for one, is more cautious in pressing expansion of its LNG export capacity as more competing LNG expansions spring up around the world, notably in the Middle East and Africa

LNG - Status in Denmark. Technology and potential. Project report

Energy Technology Data Exchange (ETDEWEB)

Naeslund, M.

2012-05-15

The interest for LNG both on a small and a large scale is increasing worldwide. The experiences and knowledge on LNG is limited in Denmark. The Danish gas companies' Technical Management Group (TCG) has asked for a status report including a technology description and an evaluation of the potential in Denmark. A survey of primarily small-scale LNG technology is done in the report. The focus is motivated by the new areas of gas utilisation that become possible with small-scale LNG. Small-scale LNG in this study is defined as LNG stored and used at the application or in an isolated gas grid. The small-scale use of LNG has today an almost negligible share of the total LNG trade but offers interesting new applications for gas utilisation. LNG on a small scale can be used primarily as: 1) Ship fuel. 2) Truck fuel (heavy duty long distance). 3) Individual users not connected to the natural gas grid. 4) Backup for upgraded biogas to individual users and vehicle fleets. 5) Security of supply or supply enhancement of heavily loaded parts of the gas grid. 6) Small-scale storage and/or peak shaving. All but the first topics are natural uses for the current Danish gas distributors. LNG as ship fuel may engage other specialized LNG companies. The report contains a technical description of the parts in primarily small-scale LNG handling and operation. Liquefaction, transport, storage, engine technologies, gas quality and safety aspects related to LNG are covered. There seem to be two more or less separate paths for LNG in Denmark, onshore and off-shore use. These are not, apparently, sharing their experiences and knowledge. Rules and regulations are also different which may create some problems in the interface, for example ship bunkering. Further studies are suggested in the area of gas quality and engine technologies and adaptation of foreign guidelines for small-scale installations to Danish conditions. These guidelines ought to be based on international standards and

Coordination of ministerial actions regarding the use of liquefied natural gas (LNG) as fuel. LNG, a European component of the energy transition in road freight transport

International Nuclear Information System (INIS)

Maler, Philippe; Erhardt, Jean-Bernard; Ourliac, Jean-Paul

2015-09-01

This report is the third of a series dealing with the coordination of ministerial actions in favor of the use of liquefied natural gas (LNG) as fuel in transports. LNG is an important potential substitute to diesel fuel in road transport and would allow significant abatement of nitrogen oxides emissions. Bio-LNG is ten times less polluting than fossil fuel LNG and thus important efforts are to be made in bio-LNG R and D. An important work has been carried out for adapting EU regulations and standards to LNG vehicles and LNG supply developments. This report presents, first, a summary of the report's recommendations and the aim of this coordination study, and, then, treats more thoroughly of the different coordination aspects: 1 - European framework of energy transition in the road freight transport (differences with maritime transport, CO 2 emissions abatement, trucks pollution and fuel quality standards, trucks technical specifications and equipment, fuel taxes in EU countries); 2 - European policy and national actions in favour of LNG development for road transport (LNG as alternate fuel, the Paris agreement, the French national energy plan); 3 - Environmental benefits of LNG in road transport (public health impacts, nitrogen oxides abatement, divergent views and expertise, LNG and CO 2 abatement measures, bio-LNG environmental evaluation; 4 - LNG development actors in road transport and the administrative coordination (professional organizations, public stakeholders, LNG topics information dissemination at the Ministry); 5 - LNG development in road transport at the worldwide, European and national scales; 6 - European regulations and standards allowing trucks LNG fueling and circulation (standard needs, users information, regulation works); 7 - Common rules to define and implement for personnel training; 8 - reflexion on LNG taxation; 9 - support policy for a road transport LNG supply chain (infrastructures, European financing, lessons learnt from maritime

Research of design challenges and new technologies for floating LNG

Directory of Open Access Journals (Sweden)

Dong-Hyun Lee

2014-06-01

Full Text Available With the rate of worldwide LNG demand expected to grow faster than that of gas demand, most major oil companies are currently investing their resources to develop floating LNG-FLNG (i.e. LNG FSRU and LNG FPSO. The global Floating LNG (FLNG market trend will be reviewed based on demand and supply chain relationships. Typical technical issues associated with FLNG design are categorized in terms of global performance evaluation. Although many proven technologies developed through LNG carrier and oil FPSO projects are available for FLNG design, we are still faced with several technical challenges to clear for successful FLNG projects. In this study, some of the challenges encountered during development of the floating LNG facility (i.e. LNG FPSO and FSRU will be reviewed together with their investigated solution. At the same time, research of new LNG-related technologies such as combined containment system will be presented.

The LNG Industry - 2014

International Nuclear Information System (INIS)

Dispenza, Domenico

2015-04-01

In the main, the global LNG industry can look back on 2014 as another year of relative stagnation with LNG trade reaching 239.2 MMT, a 1% increase over 2013, but just below 2011 levels. Although one new liquefaction plant came on stream in May in Papua New Guinea and one expansion train started producing in Algeria, disappointments in Angola and Egypt and slowdown in Qatar limited the volume of additional LNG supply. Low demand in South Korea as well as slower than expected growth in China contributed to loosen the market tightness observed in recent years, foreboding the return of a buyers' market as the year progressed. Other highlights in the past year's review of LNG imports are the remarkable gain in India, ahead of the U.K and Japan's demand increase, and the arrival of Lithuania as the world's 30. importer with a floating storage and re-gasification unit (FSRU). On the supply side, Queensland Curtis was on the brink at year-end of joining the producers' rank and managed to load its first cargo in December. Nigeria showed the second largest addition of supply (after PNG) attributable to a much improved feed-gas supply. During the second half of the year a sharp decrease in crude oil prices combined with a looser supply situation in the Pacific drove down prices in Asia, where spot prices were halved between March and October of last year. On the supply side, this price drop in Asia will inevitably slow down or defer development of expensive new supply projects. On the demand side, it has begun to translate into the return of flexible LNG cargoes to Europe, where spot prices have been disconnected from oil prices for some time. In this context of demand and price uncertainty, traditional procurement models are changing, as new players with different business models emerge, new procurement alliances are being formed and new commercial offerings are being structured; all mainly in the pursuit of enhanced flexibility both in terms of

49 CFR 193.2623 - Inspecting LNG storage tanks.

Science.gov (United States)

2010-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES: FEDERAL SAFETY STANDARDS Maintenance § 193.2623 Inspecting LNG storage tanks. Each LNG... 49 Transportation 3 2010-10-01 2010-10-01 false Inspecting LNG storage tanks. 193.2623 Section 193...

Seismic analysis of a LNG storage tank isolated by a multiple friction pendulum system

Science.gov (United States)

Zhang, Ruifu; Weng, Dagen; Ren, Xiaosong

2011-06-01

The seismic response of an isolated vertical, cylindrical, extra-large liquefied natural gas (LNG) tank by a multiple friction pendulum system (MFPS) is analyzed. Most of the extra-large LNG tanks have a fundamental frequency which involves a range of resonance of most earthquake ground motions. It is an effective way to decrease the response of an isolation system used for extra-large LNG storage tanks under a strong earthquake. However, it is difficult to implement in practice with common isolation bearings due to issues such as low temperature, soft site and other severe environment factors. The extra-large LNG tank isolated by a MFPS is presented in this study to address these problems. A MFPS is appropriate for large displacements induced by earthquakes with long predominant periods. A simplified finite element model by Malhotra and Dunkerley is used to determine the usefulness of the isolation system. Data reported and statistically sorted include pile shear, wave height, impulsive acceleration, convective acceleration and outer tank acceleration. The results show that the isolation system has excellent adaptability for different liquid levels and is very effective in controlling the seismic response of extra-large LNG tanks.

The globalization and environmental sustainability of LNG: Is LNG a fuel for the 21st century?

Energy Technology Data Exchange (ETDEWEB)

Sakmar, Susan

2010-09-15

As the world enters the 21st Century, policy makers around the world are grappling with issues related to energy security, energy poverty, global climate change, and the need to reduce greenhouse gas emissions while meeting an expected increase in demand for all energy sources. As a clean burning fuel, many policy leaders have suggested that LNG can play an important role as the world struggles to develop a more environmental sustainable energy future. Others claim that the safety and environmental impact of LNG, including life-cycle emissions, may nullify any clean burning benefit LNG might otherwise provide.

World economic growth pushing LNG use

International Nuclear Information System (INIS)

Brown, R.L.; Clary, R.

1997-01-01

Natural gas, especially liquefied (LNG), is in position to participate in the energy growth now being triggered by strong worldwide economic growth, increasingly open markets, and expanding international trade. Natural gas is abundant, burns cleanly, and is highly efficient in combined-cycle, gas-turbine power plants. Moreover, the comparative remoteness of much of the resource base to established and emerging markets can make LNG a compelling processing and transportation alternative. Discussed here are the resource distribution and emerging market opportunities that can make LNG attractive for monetizing natural-gas reserves

LNG (liquefied natural gas): A necessary part in China's future energy infrastructure

International Nuclear Information System (INIS)

Lin, Wensheng; Gu, Anzhong; Zhang, Na

2010-01-01

This paper presents an overview of the LNG industry in China, covering LNG plants, receiving terminals, transportation, and applications. Small and medium scale LNG plants with different liquefaction processes have already been built or are being built. China's first two LNG receiving terminals have been put into operation in Guangdong and Fujian, another one is being built in Shanghai, and more are being planned. China is now able to manufacture LNG road tanks and containers. The construction of the first two LNG carriers has been completed. LNG satellite stations have been built, and LNG vehicles have been manufactured. LNG related regulations and standards are being established. The prospects of LNG in China are also discussed in this paper. Interesting topics such as small-scale liquefiers, LNG cold energy utilization, coal bed methane liquefaction, LNG plant on board (FPSO - floating production, storage, and off-loading), and LNG price are introduced and analyzed. To meet the increasing demand for natural gas, China needs to build about 10 large LNG receiving terminals, and to import LNG at the level of more than 20 bcm (billion cubic metre) per year by 2020. (author)

The economic value of LNG in the Korean manufacturing industry

International Nuclear Information System (INIS)

Park, Sun-Young; Yoo, Seung-Hoon

2013-01-01

Although LNG is an important input to industrial production for manufacturing firms, its economic value has been rarely investigated in the literature. This paper attempts to estimate the economic value of LNG in Korea's manufacturing sector by employing the concept of the value of marginal product (VMP). For this, we used data on 328 firms using LNG as an input. Two types of production functions (the Cobb–Douglas and trans-log functions) are applied. The result of the specification test indicates that the trans-log function is more appropriate for estimating the data. The output elasticity and VMP of industrial LNG are estimated to be 0.1346 and KRW 6844 (USD 6.22) per m 3 , respectively. The results have important implications for various areas of industrial LNG management. For example, any cost–benefit analysis of new projects providing industrial LNG requires information on the economic value of industrial LNG. In addition, such information is useful for the Korean government's future policies on LNG pricing. - Highlights: • We estimate the economic value of LNG in the Korean manufacturing industry. • We employ the concept of the value of marginal product (VMP). • The VMP of industrial LNG is estimated to be KRW 6844 (USD 6.22) per m 3 . • It significantly outweighs the price of industrial LNG (KRW 629.4 per m 3 )

Russian LNG: The Long Road to Export

International Nuclear Information System (INIS)

Mitrova, Tatiana

2013-12-01

On December 1, 2013 a law on liquefied natural gas (LNG) export liberalization came into legal force in Russia. The law grants two categories of companies other than Russia's state gas giant Gazprom and its subsidiary companies the right to export LNG: (1) users of mineral resources that have a license to construct an LNG plant or to send their gas production for liquefaction, and (2) companies that are more than 50% owned by the Russian government, for gas produced from Russian offshore fields or under production-sharing agreements. This is-without exaggeration-a historic decision for the Russian gas industry, the path to which was certainly not easy. Recent years have seen a radical change in the global economic climate, which has changed the dynamics of the European gas market (gas demand decline and Russian gas import reduction, changing pricing mechanism for a much higher share of spot indexing, European Commission anti-trust investigations against Gazprom, etc) and is increasingly pushing Russia to diversify its gas exports. However, diversifying exports through the development of LNG has proven to be not so simple. Over the past 20 years, with the exception of the Sakhalin-2 project, structured under a project-sharing agreement (PSA) rather than in the framework of national legislation, all other projects failed to come close to completion. The Kharasavey and Baltic LNG projects were abandoned in the early stages of project evaluation, while the Shtokman project progressed to the point of the operating company being created, but in the end was postponed indefinitely. The first stage of LNG development in Russia ended in failure. However, the Russian government considers the development of LNG exports to be a priority, which can be evidenced in all official policy papers. It is believed that LNG will help in achieving a set of objectives, namely: increasing the absolute volume of exports, allowing the country to enter into previously inaccessible markets

LNG terminalil on idaraha keeld / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2011-01-01

Euroopa Komisjon kiirustab Balti riike LNG (vedeldatud maagaasi) terminali asukohas kokku leppima. Kolmest tingimusest, millele peab LNG terminali projekt vastama, et tekiks võimalus kandideerida EL-i toetusele

French Gas Association roundtable - May 27, 2013. Evolutions of the LNG market

International Nuclear Information System (INIS)

Robin, Jean-Yves; Brunero, Francois; Cotin, Pierre; Daubonne, Jean-Francois; Deybach, Frederic; Seilhan, Bruno

2013-01-01

The LNG industry is currently facing contrasting trends, with overall decreasing consumption in 2012 compared to the previous year, large uncertainties on gas prices - energy being regarded by European and Asian customers as costly - and however very encouraging prospects, in particular regarding LNG as a fuel. This document reports on the minutes of the French Gas Association roundtable on the subject 'Evolutions of the LNG market'. Contents: 1) LNG Market Outlook, 2) LNG in Europe, 3) LNG terminals and the evolving LNG market, 4) The road-transported LNG market, 5) LNG market trends, 6) Questions and Answers

LNG imports make strong recovery in 1996; exports increase also

International Nuclear Information System (INIS)

Swain, E.J.

1998-01-01

LNG imports to the US jumped in 1996 as Algerian base-load plants resumed operations following major revamps. Exports from Alaska to Japan grew by nearly 4% over 1995. Total LNG imports to the US in 1996 were 40.27 bcf compared to 17.92 bcf in 1995, an increase of 124.8%. Algeria supplied 35.32 bcf; Abu Dhabi, 4.95 bcf. About 82.3% of the imported LNG was received at Distrigas Corp.'s terminal north of Boston. The remaining LNG was received at the Pan National terminal in Lake Charles, LA. LNG imports during 1995 fell to such a low level not because of depressed US demand but because of limited supply. The paper discusses LNG-receiving terminals, base-load producers, LNG pricing, and exports

Improvement of plant reliability in PT. Badak LNG plant

International Nuclear Information System (INIS)

Achmad, S.; Somantri, A.

1997-01-01

PT. Badak's LNG sales commitment has been steadily increasing, therefore, there has been more emphasis to improve and maintain the LNG plant reliability. From plant operation historical records, Badak LNG plant experienced a high number of LNG process train trips and down time for 1977 through 1988. The highest annual number of LNG plant trips (50 times) occurred in 1983 and the longest LNG process train down time (1259 train-hours) occurred in 1988. Since 1989, PT. Badak has been able to reduce the number of LNG process train trips and down time significantly. In 1994 the number of LNG process train trips and was 18 times and the longest LNG process train down time was 377 train-hours. This plant reliability improvement was achieved by implementing plant reliability improvement programs beginning with the design of the new facilities and continuing with the maintenance and modification of the existing facilities. To improve reliability of the existing facilities, PT. Badak has been implementing comprehensive maintenance programs, to reduce the frequency and down time of the plant, such as Preventive and Predictive Maintenance as well as procurement material improvement since PT. Badak location is in a remote area. By implementing the comprehensive reliability maintenance, PT. Badak has been able to reduce the LNG process train trips to 18 and down time to 337 train hours in 1994 with the subsequent maintenance cost reduction. The average PT. Badak plant availability from 1985 to 1995 is 94.59%. New facilities were designed according to the established PT. Badak design philosophy, master plan and specification. Design of new facilities was modified to avoid certain problems from past experience. (au)

76 FR 53440 - Freeport LNG Development, LP; Freeport LNG Expansion, LP; FLNG Liquefaction LLC; Notice of Intent...

Science.gov (United States)

2011-08-26

.... Summary of the Planned Project Freeport plans to add natural gas liquefaction and exportation capabilities to its existing liquefied natural gas (LNG) import terminal on Quintana Island in Brazoria County... tank, and additional LNG vaporization and natural gas send-out facilities that were previously...

Research on energy efficiency design index for sea-going LNG carriers

Science.gov (United States)

Lin, Yan; Yu, Yanyun; Guan, Guan

2014-12-01

This paper describes the characteristics of liquefied natural gas (LNG) carriers briefly. The LNG carrier includes power plant selection, vapor treatment, liquid cargo tank type, etc. Two parameters—fuel substitution rate and recovery of boil of gas (BOG) volume to energy efficiency design index (EEDI) formula are added, and EEDI formula of LNG carriers is established based on ship EEDI formula. Then, based on steam turbine propulsion device of LNG carriers, mathematical models of LNG carriers' reference line value are established in this paper. By verification, the EEDI formula of LNG carriers described in this paper can provide a reference for LNG carrier EEDI calculation and green shipbuilding.

LNG As an Alternative Energy Supply in Sweden

Energy Technology Data Exchange (ETDEWEB)

Hansson, Jens [Lund Univ., Dept. of Chemical Engineering, Lund (Sweden)

2008-11-15

As well as summarising the possible alternatives, environmental aspects and uses of LNG, this study aims to investigate the cost involved in the import of LNG to Sweden, from well to user. In Sweden, Natural Gas is used to cover 2 % of the total energy input. The pipeline network stretches from Malmoe to Stenungsund and Gnosjoe, which means some of the most densely populated areas are covered, but there is still 1200 km of the country left, including larger cities such as Stockholm, Uppsala and Linkoeping as well as areas that host some of the most energy demanding industries, e.g. Sundsvall, Umeaa, Luleaa and Kiruna. The absence of Natural Gas typically causes these regions to rely on fuel oil, coke or coal. If these sources of energy could be replaced by Natural Gas, great environmental benefits could be achieved. Research shows that the use of Natural Gas adds 20 % less CO{sub 2} to the atmosphere than oil and also mean lower emissions of NO{sub x}, SO{sub 2} and particles, making it the better alternative from both local and global perspectives. LNG is potentially a fire and an explosion hazard, but in the last 45 years of usage, no major accidents have occurred. Major exporters of LNG are Indonesia, Quatar, Australia and Algeria. Some of the largest importers are Japan, USA, France and Spain. Japan imports nearly 100 % of their Natural Gas as LNG. The available LNG liquefaction capacity increased by 60 % between 2002 and 2007. The total import cost for LNG includes the purchase cost from the producer, the transport cost, be it sea, railroad or road transport, and the cost for the terminal which receives and stores LNG. The study of different routes, volumes and means of transport creates a picture of how the total cost varies in proportion to these parameters. In the calculation of these costs, sources from the industry or estimations of purchase prices, transport costs and terminal costs are used. The uncertainties in this study are especially high when it

LNG As an Alternative Energy Supply in Sweden

Energy Technology Data Exchange (ETDEWEB)

Hansson, Jens (Lund Univ., Dept. of Chemical Engineering, Lund (Sweden))

2008-11-15

As well as summarising the possible alternatives, environmental aspects and uses of LNG, this study aims to investigate the cost involved in the import of LNG to Sweden, from well to user. In Sweden, Natural Gas is used to cover 2 % of the total energy input. The pipeline network stretches from Malmoe to Stenungsund and Gnosjoe, which means some of the most densely populated areas are covered, but there is still 1200 km of the country left, including larger cities such as Stockholm, Uppsala and Linkoeping as well as areas that host some of the most energy demanding industries, e.g. Sundsvall, Umeaa, Luleaa and Kiruna. The absence of Natural Gas typically causes these regions to rely on fuel oil, coke or coal. If these sources of energy could be replaced by Natural Gas, great environmental benefits could be achieved. Research shows that the use of Natural Gas adds 20 % less CO{sub 2} to the atmosphere than oil and also mean lower emissions of NO{sub x}, SO{sub 2} and particles, making it the better alternative from both local and global perspectives. LNG is potentially a fire and an explosion hazard, but in the last 45 years of usage, no major accidents have occurred. Major exporters of LNG are Indonesia, Quatar, Australia and Algeria. Some of the largest importers are Japan, USA, France and Spain. Japan imports nearly 100 % of their Natural Gas as LNG. The available LNG liquefaction capacity increased by 60 % between 2002 and 2007. The total import cost for LNG includes the purchase cost from the producer, the transport cost, be it sea, railroad or road transport, and the cost for the terminal which receives and stores LNG. The study of different routes, volumes and means of transport creates a picture of how the total cost varies in proportion to these parameters. In the calculation of these costs, sources from the industry or estimations of purchase prices, transport costs and terminal costs are used. The uncertainties in this study are especially high when it

The conception of the LNG implementation in Poland

International Nuclear Information System (INIS)

Skwarczynski, S.; Zola, P.

2006-01-01

The main issues concerning world LNG market, technical applications and the potential growth of the market have been described in the article. The conception of introducing LNG on Polish gas market assumes that a LNG terminal will be built on the Baltic Sea shore along with the infrastructure necessary to store and transmit gas to the national gas pipeline grid. (authors)

LNG in transportation

International Nuclear Information System (INIS)

Madden, Mike; White, Nick; Le Fevre, Chris

2014-01-01

This document summarizes the content of a 402 p. study published by CEDIGAZ, the International Center for Natural Gas Information. According to this study, LNG as a fuel will capture a significant market share in the transport sector by 2035. The greatest potential is seen in road transport, were annual demand is projected to reach 96 million tons per year (mtpa) in CEDIGAZ' base scenario while demand in the marine sector could grow to an estimated 77 mtpa. The rail sector could add another 6 mtpa to global demand. However, the development of LNG as a transport fuel faces a number of challenges, and will have to go hand in hand with the development of fueling infrastructure

Introduction to the marine transportation of bulk LNG and the design of LNG carriers

Energy Technology Data Exchange (ETDEWEB)

Wilson, J J

1974-03-01

The marine transportation of bulk LNG is expected to expand considerably in the near future to help supply the continuous and growing demand for energy predicted for the U.S., Japan, and Western Europe. The number of new LNG tankers required to provide for these markets is estimated to be at least 50 new 4.4 million ft/sup 3/ tankers by 1980. The standard LNG tanker size is expected to increase to 7.06 million ft/sup 3/ within 5 yr. In selecting a particular tanker system, prospective ship-owners may have to consider such factors as national and international subsidies, shipyard limitations, and the trend to build certain specialized tanker components in areas other than in the shipyard. This work separation could help reduce tanker construction cost and time--especially important when several ships are to be constructed. Containment techniques available for construction of the cargo tanks include the self-supporting and the integrated designs, with the most economical provided by systems carrying LNG as a bulk cargo slightly subcooled below its boiling temperature at near-atmospheric pressure. All designs must fulfill the requirements for maintaining the approved temperature over the entire hull structure, preventing excess heat leaks into the cargo, providing tight liquid containment of the cargo, controlling the conditions inside and outside, and providing the proper facilities for safe loading and unloading. Materials of construction range from a combination of various grades of mild steel for the hull to the highest grades of aluminum alloys and nickel steels for the tank areas. Insulation includes polyurethane foam, silicon-coated perlite, and balsa wood used with fiberglass, polyurethane foam, or mineral wool. The insulation materials and arrangement must be waterproof, fire-resistant, and suitable to withstand the forces imposed on them. Finally, the tankers must include the proper equipment for LNG handling, pumping, and boiloff control.

Safety and environmental aspects in LNG carrier design

International Nuclear Information System (INIS)

Takashi Yoneyama

1997-01-01

'Safety and Reliability' has been and will continue to be a key phr ase in marine transportation of LNG. Mitsui Engineering and Shipbuilding Co.,Ltd. has utilized its all expertise and state of art technologies to realize this objective, resulting in exceptionally successful operations of LNG carrier built by the Co. In line with growing global concern about environmental issues, we need to pay more attention to the environmental aspects of the design and construction of LNG carriers. Accordingly, in this paper, we present some topics related safety and environmental concerns which need to be taken into consideration in LNG carriers design and construction. (Author). 7 figs

Safety and environmental aspects in LNG carrier design

Energy Technology Data Exchange (ETDEWEB)

Yoneyama, Takashi [Mitsui Shipbuilding and Engineering Co. Ltd., Tokyo (Japan)

1997-06-01

`Safety and Reliability` has been and will continue to be a key phr ase in marine transportation of LNG. Mitsui Engineering and Shipbuilding Co.,Ltd. has utilized its all expertise and state of art technologies to realize this objective, resulting in exceptionally successful operations of LNG carrier built by the Co. In line with growing global concern about environmental issues, we need to pay more attention to the environmental aspects of the design and construction of LNG carriers. Accordingly, in this paper, we present some topics related safety and environmental concerns which need to be taken into consideration in LNG carriers design and construction. (Author). 7 figs.

49 CFR 193.2181 - Impoundment capacity: LNG storage tanks.

Science.gov (United States)

2010-10-01

... LIQUEFIED NATURAL GAS FACILITIES: FEDERAL SAFETY STANDARDS Design Impoundment Design and Capacity § 193.2181 Impoundment capacity: LNG storage tanks. Each impounding system serving an LNG storage tank must have a... 49 Transportation 3 2010-10-01 2010-10-01 false Impoundment capacity: LNG storage tanks. 193.2181...

77 FR 43589 - Freeport LNG Development, L.P., Freeport LNG Expansion, L.P., FLNG Liquefaction LLC; Supplemental...

Science.gov (United States)

2012-07-25

... addition, a second ship berthing area, third LNG storage tank, and additional LNG vaporization and natural... 7.3 7.3 Appurtenant Facilities beyond Terminal Site and Pretreatment 0.1 0.1 0.2 Facility site and... issues that we think deserve attention based on a preliminary review of the planned facilities and the...

LNG in eastern Canada and New England : market update

International Nuclear Information System (INIS)

Schlesinger, B.

2005-01-01

This presentation provided an overview of the gas markets in North America and discussed the rationale for developing the liquefied natural gas (LNG) market with reference to competitive issues, challenges and global dimensions. LNG is expected to play a greater role in North American gas supplies and markets due to the decrease in conventional natural gas production in North America and the increase in demand for energy. It is expected that the overall share of the LNG gas market will increase in 2002. The construction of at least 15 new LNG receiving terminals has been proposed for location in the U.S., Canada, and Mexico, with most being located along the Gulf Coast. A novel offshore LNG receiving concept involving offshore gas pipelines and on-board-ship regasification was also discussed. As trading of LNG increases in the Atlantic, markets in eastern United States and Canada will benefit from improved gas supplies. Pricing patterns are also expected to change. It was noted that the increased energy demand will enable Arctic gas supplies to enter markets. As such, Arctic gas pipelines will enter service in the next decade and Alberta's importance as a hub will grow. It was also noted that Arctic gas will not have a significant influence on reducing LNG import volumes. figs

Project financing knits parts of costly LNG supply chain

International Nuclear Information System (INIS)

Minyard, R.J.; Strode, M.O.

1997-01-01

The supply and distribution infrastructure of an LNG project requires project sponsors and LNG buyers to make large, interdependent capital investments. For a grassroots project, substantial investments may be necessary for each link in the supply chain: field development; liquefaction plant and storage; ports and utilities; ships; receiving terminal and related facilities; and end-user facilities such as power stations or a gas distribution network. The huge sums required for these projects make their finance ability critical to implementation. Lenders have become increasingly comfortable with LNG as a business and now have achieved a better understanding of the risks associated with it. Raising debt financing for many future LNG projects, however, will present new and increasingly difficult challenges. The challenge of financing these projects will be formidable: political instability, economic uncertainty, and local currency volatility will have to be recognized and mitigated. Described here is the evolution of financing LNG projects, including the Rasgas LNG project financing which broke new ground in this area. The challenges that lie ahead for sponsors seeking to finance future projects selling LNG to emerging markets are also discussed. And the views of leading experts from the field of project finance, specifically solicited for this article, address major issues that must be resolved for successful financing of these projects

LNG : its potential impact on North American markets

International Nuclear Information System (INIS)

Schlesinger, B.

2003-01-01

Liquefied natural gas (LNG) is expected to play a greater role in North American gas supplies and markets due to the decrease in conventional natural gas production in North America accompanied by an increase in demand for energy. It is expected that the overall share of the LNG gas market will rise from about 1.4 per cent in 2002 to more than 5 per cent by 2020, and potentially up to 15 per cent by that year. The construction of at least 15 new LNG receiving terminals has been proposed for location in the U.S., Canada, and Mexico. In addition, El Paso has proposed a novel offshore LNG receiving concept involving offshore gas pipelines and on-board-ship regasification. As trading of LNG increases in the Atlantic, markets in eastern United States and Canada will benefit from improved gas supplies, but pricing patterns are expected to change. Basis differentials along the Atlantic coastline will probably diminish, potentially reducing the value of Sable Island gas and the pipeline system that runs north to south along the eastern coast of North America. It was noted that Middle Eastern suppliers of LNG will play an important potential role in North American markets. 19 figs

LNG (liquefied natural gas): A necessary part in China's future energy infrastructure

Energy Technology Data Exchange (ETDEWEB)

Lin, Wensheng; Gu, Anzhong [Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai 200240 (China); Zhang, Na [Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100080 (China)

2010-11-15

This paper presents an overview of the LNG industry in China, covering LNG plants, receiving terminals, transportation, and applications. Small and medium scale LNG plants with different liquefaction processes have already been built or are being built. China's first two LNG receiving terminals have been put into operation in Guangdong and Fujian, another one is being built in Shanghai, and more are being planned. China is now able to manufacture LNG road tanks and containers. The construction of the first two LNG carriers has been completed. LNG satellite stations have been built, and LNG vehicles have been manufactured. LNG related regulations and standards are being established. The prospects of LNG in China are also discussed in this paper. Interesting topics such as small-scale liquefiers, LNG cold energy utilization, coal bed methane liquefaction, LNG plant on board (FPSO - floating production, storage, and off-loading), and LNG price are introduced and analyzed. To meet the increasing demand for natural gas, China needs to build about 10 large LNG receiving terminals, and to import LNG at the level of more than 20 bcm (billion cubic metre) per year by 2020. (author)

The LNG industry - 2008

International Nuclear Information System (INIS)

2008-01-01

The average annual growth of the world primary energy consumption has been 2.2% over the last ten years, with the highest growth rate observed for 2004 (+4.7%). In 2007, world primary energy consumption registered a 2.4% increase, still exceeding the 10-year average but less than for the four previous years. As for the previous years, the Asia Pacific region shows the most important increase in volume for 2007, rising by 5% and accounting for two-third of the global growth (China alone accounts in 2007 for more than half of this global growth, as was already the case in 2005 and 2006). Over the last ten years, the world energy consumption rose from 8920 10 6 toe in 1998 to 11099 10 6 toe in 2007, a 24.4% overall increase. For the seventh year running, coal has increased its share of the overall energy market, up to 28.6%. It should be noted that nuclear power decreased by 2%, Germany and Japan accounting for more than 90% of this decline. The growth of natural gas consumption in 2007 (+3.1%) was higher than in 2006 (+2.4%). The US accounted for nearly half of the global increase. Strong growth was also observed in China (+19.9%), representing the second largest increment to world gas consumption. Inversely, the EU consumption decreased (-1.6%) for the second year in a row. The market share for natural gas remained stable in 2007 (23.8%) compared to 2006 (23.6%)(1). Estimates for the marketed production of natural gas in 2008(2) show a rise of about 3.4% over 2007. The share of LNG in the gas trade accounts for 27% of the total (excluding trade within the Former Soviet Union and United Arab Emirates). Details are given about: LNG contracts and trade, Contracts concluded in 2008, LNG imports - Sources of imports, Quantities received in 2008, LNG tankers, Ships delivered, Tanker distribution, Liquefaction plants, Re-gasification plants, Contracts in force in 2008, Spot and short term quantities received in 2008, Sea transportation routes, Liquefaction plants, Re

Going global: LNG could open up gas market

International Nuclear Information System (INIS)

Jaremko, D.

2004-01-01

The probability of liquefied natural gas becoming a major source of energy in North America is discussed. Although the safety of the technology of transporting LNG was proven more than 40 years ago, there are considerable hurdles to be overcome when it comes to establishing LNG terminals. Industry insiders contend that the obstacles to finding suitable sites are primarily NIMBY (not-in-my-backyard) or BANANA (build-absolutely-nothing-anywhere-near-anyone) issues that will be overcome in time with better public information as to what the real hazards are, but the time is not yet ripe for any serious LNG development. Proposed LNG projects in Malaysia, Nigeria, Angola are reviewed, in addition to four projects in the United States, one in the Gulf of Mexico, and three along the American east coast. A Canadian project at Bear Head near Point Tupper, Nova Scotia, which has support from the business community, government and industry, and would provide the shortest distance to eastern North American markets for Atlantic basin shippers is also reviewed. LNG technological and transportation issues apart, there is also direct competition from the long-proposed Alaska pipeline which, if and when built, will provide long-term steady supply of gas for the U. S. market. Alaskan natural gas is clearly the preferred alternative to LNG at the present time

Distribution of gas from Canaport LNG

International Nuclear Information System (INIS)

Thompson, W.

2006-01-01

Construction of the Canaport Liquefied Natural Gas (LNG) project will begin in 2006. Public consultations are currently being held for the 145 km pipeline from Canaport to Bailleyville, Maine. It is expected that both the facility and the pipeline will be operational by 2008. This presentation provided details of the New Brunswick (NB) Department of Energy's (DOE) regulatory oversight of the Canaport Liquefied Natural Gas (LNG) project. The DOE is responsible for ensuring diversity and security of supply; economic efficiency; economic development opportunities and protection of the environment. The Canaport LNG facility will provide an additional 500 to 600 temporary jobs over a 2 to 3 year period, as well as 20 full-time jobs once the plant is operational. Tax revenues, access roads and the construction of a pipeline to Bailleyville, Maine will also have positive impacts on the NB economy. The facility will provide a secure long term supply of natural gas for the region. In order to support its energy goals, the DOE has proposed amendments to provide for the distribution of gas from the plant to NB customers. A proposed LNG franchise to allow for direct distribution of gas from the LNG plant to customers was discussed. Issues concerning the Gas Distribution Act and the New Pipeline Act of 2006 were also examined. It was concluded that public consultations are currently being held for the 145 km pipeline, and that both the facility and the pipeline are expected to be operational by 2008. refs., tabs., figs

Siting considerations for LNG import terminals

Energy Technology Data Exchange (ETDEWEB)

Meratla, Z. [CDS Research Ltd., Vancouver, BC (Canada)

2005-07-01

Site selection criteria for liquefied natural gas (LNG) facilities and terminals were reviewed in this PowerPoint presentation. Onshore and offshore sites were discussed. Typical public opposition issues were examined, including public concerns over safety and the environment. Low key consultation processes with local communities was advised to assess levels of interest and opposition during initial stages. It was suggested that desirable LNG sites should not be visible from local communities. Remoteness from built-up areas was advised, as well as ensuring that sites meet the requirements of future expansion and large LNG carriers. Issues concerning waterway drawbacks and exclusion zones were examined, as well as the relative merits of onshore and offshore terminals. It was noted that onshore terminals are accessible to personnel as well as outside emergency response resources, and are less susceptible to weather related downtime. In addition, onshore spills are generally impounded. Offshore LNG import terminals are visible from shorelines and susceptible to stray marine traffic and abnormal events. Siting considerations for offshore facilities include sensitive areas; shipping channels; foundation issues; shipping lane access; and offshore pipeline lengths. Issues concerning loading arms, remote flare systems, integral ballast and process equipment for offshore facilities were discussed. Membrane type storage systems and tank construction details were presented as well as details of self supporting storage systems. A comparison of gravity-based structures and floating facilities was presented. It was concluded that floating LNG facilities have well developed security procedures, passive protection and automatic intruder detection alarms. tabs., figs.

Distribution of gas from Canaport LNG

Energy Technology Data Exchange (ETDEWEB)

Thompson, W. [New Brunswick Dept. of Energy, Fredericton, NB (Canada)

2006-07-01

Construction of the Canaport Liquefied Natural Gas (LNG) project will begin in 2006. Public consultations are currently being held for the 145 km pipeline from Canaport to Bailleyville, Maine. It is expected that both the facility and the pipeline will be operational by 2008. This presentation provided details of the New Brunswick (NB) Department of Energy's (DOE) regulatory oversight of the Canaport Liquefied Natural Gas (LNG) project. The DOE is responsible for ensuring diversity and security of supply; economic efficiency; economic development opportunities and protection of the environment. The Canaport LNG facility will provide an additional 500 to 600 temporary jobs over a 2 to 3 year period, as well as 20 full-time jobs once the plant is operational. Tax revenues, access roads and the construction of a pipeline to Bailleyville, Maine will also have positive impacts on the NB economy. The facility will provide a secure long term supply of natural gas for the region. In order to support its energy goals, the DOE has proposed amendments to provide for the distribution of gas from the plant to NB customers. A proposed LNG franchise to allow for direct distribution of gas from the LNG plant to customers was discussed. Issues concerning the Gas Distribution Act and the New Pipeline Act of 2006 were also examined. It was concluded that public consultations are currently being held for the 145 km pipeline, and that both the facility and the pipeline are expected to be operational by 2008. refs., tabs., figs.

First LNG deliveries from Qatar to Japan

International Nuclear Information System (INIS)

Legros, E.J.

1997-01-01

Twenty five years after the discovery of the giant North Field natural gas deposit, the Qatargas company has delivered its first LNG freight to Japan in December 1996. This paper recalls the history of the company from the discovery of the offshore North Field, its valorization and development, the LNG project with the building of the Ras Laffan harbour and its condensates processing factory and the 3 offshore production platforms. Ten methane-tanker ships will be in operation in the year 2000. Qatar's LNG exports should reach 20 to 25 Mt/year in the next ten years, when all its liquefaction factory projects will be completed. (J.S.)

Design Optimization of a Low Pressure LNG Fuel Supply System

OpenAIRE

Nguyen, Kim

2015-01-01

In 2014 there were 50 liquefied natural gas (LNG) fuelled ships in operation and around 70 on order worldwide. LNG proves to emit less pollution and considering the present and future emission regulations and optimistic gas fuel prices, LNG would be a preferable option as a marine fuel. The number of LNG fuelled ships is therefore likely to increase significantly the next five to ten years. There are many ways to configure the fuel supply system. The fuel supply system consists of a tank,...

Liquefied natural gas (LNG) : production, storage and handling. 7. ed.

Energy Technology Data Exchange (ETDEWEB)

Kalra, S; Jaron, K; Adragna, M; Coyle, S; Foley, C; Hawryn, S; Martin, A; McConnell, J [eds.

2003-07-01

This Canadian Standard on the production, storage and handling of liquefied natural gas (LNG) was prepared by the Technical Committee on Liquefied Natural Gas under the jurisdiction of the Steering Committee on Oil and Gas Industry Systems and Materials. It establishes the necessary requirements for the design, installation and safe operation of LNG facilities. The Standard applies to the design, location, construction, operation and maintenance of facilities at any location of the liquefaction of natural gas and for the storage, vaporization, transfer, handling and truck transport of LNG. The training of personnel involved is also included as well as containers for LNG storage, including insulated vacuum systems. It includes non-mandatory guidelines for small LNG facilities but does not apply to the transportation of refrigerants, LNG by rail, marine vessel or pipeline. This latest edition contains changes in working of seismic design requirements and minor editorial changes to several clauses to bring the Standard closer to the US National Fire Protection Association's Committee on Liquefied Natural Gas Standard while maintaining Canadian regulatory requirements. The document is divided into 12 sections including: general requirements; plant site provisions; process equipment; stationary LNG storage containers; vaporization facilities; piping system and components; instrumentation and electrical services; transfer of LNG and refrigerants; fire protection, safety and security; and, operating, maintenance and personnel training. This Standard, like all Canadian Standards, was subject to periodic review and was most recently reaffirmed in 2003. 6 tabs., 6 figs., 3 apps.

The Phoenix series large scale LNG pool fire experiments.

Energy Technology Data Exchange (ETDEWEB)

Simpson, Richard B.; Jensen, Richard Pearson; Demosthenous, Byron; Luketa, Anay Josephine; Ricks, Allen Joseph; Hightower, Marion Michael; Blanchat, Thomas K.; Helmick, Paul H.; Tieszen, Sheldon Robert; Deola, Regina Anne; Mercier, Jeffrey Alan; Suo-Anttila, Jill Marie; Miller, Timothy J.

2010-12-01

The increasing demand for natural gas could increase the number and frequency of Liquefied Natural Gas (LNG) tanker deliveries to ports across the United States. Because of the increasing number of shipments and the number of possible new facilities, concerns about the potential safety of the public and property from an accidental, and even more importantly intentional spills, have increased. While improvements have been made over the past decade in assessing hazards from LNG spills, the existing experimental data is much smaller in size and scale than many postulated large accidental and intentional spills. Since the physics and hazards from a fire change with fire size, there are concerns about the adequacy of current hazard prediction techniques for large LNG spills and fires. To address these concerns, Congress funded the Department of Energy (DOE) in 2008 to conduct a series of laboratory and large-scale LNG pool fire experiments at Sandia National Laboratories (Sandia) in Albuquerque, New Mexico. This report presents the test data and results of both sets of fire experiments. A series of five reduced-scale (gas burner) tests (yielding 27 sets of data) were conducted in 2007 and 2008 at Sandia's Thermal Test Complex (TTC) to assess flame height to fire diameter ratios as a function of nondimensional heat release rates for extrapolation to large-scale LNG fires. The large-scale LNG pool fire experiments were conducted in a 120 m diameter pond specially designed and constructed in Sandia's Area III large-scale test complex. Two fire tests of LNG spills of 21 and 81 m in diameter were conducted in 2009 to improve the understanding of flame height, smoke production, and burn rate and therefore the physics and hazards of large LNG spills and fires.

The Pacific Basin LNG trade: a return to fundamentals

International Nuclear Information System (INIS)

Baharuddin, H.

1991-01-01

The LNG business in the Pacific Region is unique because there is no other source of energy in which seller and buyer sign contracts for 20-year periods. This long-term relationship is based on mutual buyer/seller cooperation, and mutual buyer/seller recognition of the financial and commercial challenges faced by all links in the LNG Supply Chain. However, there are now concerns that those involved in the LNG business were ignoring the fundamentals of the trade. The buyer expected the seller to absorb higher transportation costs, easing take or pay terms, more flexibility, evergreen options on uncommitted capacity, etc. On the other side, sellers expected larger baseload quantities, equitable sharing of LNG chain risks with consumers. (author)

The Asia Pacific LNG trade: Status and technology development

International Nuclear Information System (INIS)

Hovdestad, W.R.

1995-01-01

The Asia Pacific Region is experiencing a period of sustained economic expansion. Economic growth has led to an increasing demand for energy that has spurred a rapid expansion of baseload liquefied natural gas (LNG) facilities in this region. This is illustrated by the fact that seven of the ten baseload facilities in existence provide LNG for markets in the Asia Pacific region. With the three exceptions having been initially commissioned in 1972 and earlier, it is fair to observed that most advances in LNG technology have been developed and applied for this market. The paper presents the current status and identified future trends for the Asia Pacific LNG trade. Technology development in terms of application to onstream production, processing and transportation facilities, including LNG tankers, is presented. The potential of future advances to applied technology and operational practices to improve the cost-effectiveness of new and existing facilities is discussed. Current design data and methods as actually used are examined in terms of identifying where fundamental research and basic physical data are insufficient for optimization purposes. These findings are then summarized and presented in terms of the likely evolution of future and existing LNG projects in the Asia Pacific region

Novel design of LNG (liquefied natural gas) reliquefaction process

Energy Technology Data Exchange (ETDEWEB)

Baek, S., E-mail: s.baek@kaist.ac.kr [Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 373-1, Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Hwang, G.; Lee, C. [Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 373-1, Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Jeong, S., E-mail: skjeong@kaist.ac.kr [Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 373-1, Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Choi, D. [Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 373-1, Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Ship/Plant System R and D Team, Daewoo Shipbuilding and Marine Engineering Co., Ltd., 1, Ajoo, Koje, Kyungnam 656-714 (Korea, Republic of)

2011-08-15

Highlights: {yields} We performed experiments with LN2 to mock up the new LNG reliquefaction process. {yields} Subcooled liquid goes to heat exchanger, heater, and phase separator. {yields} Reliquefaction occurs when vapor enters heat exchanger and verified by experiments. {yields} Reliquefaction ratio increases when subcooling degree or system pressure increases. - Abstract: This paper presents an investigation of novel LNG reliquefaction process where the cold exergy of subcooled LNG is utilized to recondense the vaporized light component of LNG after it is separated from the heavier component in a phase separator. The regeneration of cold exergy is especially effective as well as important in thermodynamic sense when a cryogenic process is involved. To verify the proposed idea, we performed an experimental study by facilitating liquid nitrogen apparatus to mock up the LNG reliquefaction process. Subcooled liquid nitrogen is produced for a commercial transportation container with a house-made atmospheric liquid nitrogen heat exchanger and then, having subooled degree of up to 19 K, it simulates the behavior of subcooled LNG in the lab-scale reliquefaction experiment. Recondensation of the vaporized gas is possible by using the cold exergy of subcooled liquid in a properly fabricated heat exchanger. Effect of heat exchanger performance factor and degree of subcooling on recondensation portion has been discussed in this paper. It is concluded that utilizing pressurized subcooled liquid that is obtained by liquid pump can surely reduce the pumping power of the vaporized natural gas and save the overall energy expenditure in LNG reliquefaction process.

Novel design of LNG (liquefied natural gas) reliquefaction process

International Nuclear Information System (INIS)

Baek, S.; Hwang, G.; Lee, C.; Jeong, S.; Choi, D.

2011-01-01

Highlights: → We performed experiments with LN2 to mock up the new LNG reliquefaction process. → Subcooled liquid goes to heat exchanger, heater, and phase separator. → Reliquefaction occurs when vapor enters heat exchanger and verified by experiments. → Reliquefaction ratio increases when subcooling degree or system pressure increases. - Abstract: This paper presents an investigation of novel LNG reliquefaction process where the cold exergy of subcooled LNG is utilized to recondense the vaporized light component of LNG after it is separated from the heavier component in a phase separator. The regeneration of cold exergy is especially effective as well as important in thermodynamic sense when a cryogenic process is involved. To verify the proposed idea, we performed an experimental study by facilitating liquid nitrogen apparatus to mock up the LNG reliquefaction process. Subcooled liquid nitrogen is produced for a commercial transportation container with a house-made atmospheric liquid nitrogen heat exchanger and then, having subooled degree of up to 19 K, it simulates the behavior of subcooled LNG in the lab-scale reliquefaction experiment. Recondensation of the vaporized gas is possible by using the cold exergy of subcooled liquid in a properly fabricated heat exchanger. Effect of heat exchanger performance factor and degree of subcooling on recondensation portion has been discussed in this paper. It is concluded that utilizing pressurized subcooled liquid that is obtained by liquid pump can surely reduce the pumping power of the vaporized natural gas and save the overall energy expenditure in LNG reliquefaction process.

Thermodynamic Processes Involving Liquefied Natural Gas at the LNG Receiving Terminals / Procesy termodynamiczne z wykorzystaniem skroplonego gazu ziemnego w terminalach odbiorczych LNG

Science.gov (United States)

Łaciak, Mariusz

2013-06-01

The increase in demand for natural gas in the world, cause that the production of liquefied natural gas (LNG) and in consequences its regasification becoming more common process related to its transportation. Liquefied gas is transported in the tanks at a temperature of about 111K at atmospheric pressure. The process required to convert LNG from a liquid to a gas phase for further pipeline transport, allows the use of exergy of LNG to various applications, including for electricity generation. Exergy analysis is a well known technique for analyzing irreversible losses in a separate process. It allows to specify the distribution, the source and size of the irreversible losses in energy systems, and thus provide guidelines for energy efficiency. Because both the LNG regasification and liquefaction of natural gas are energy intensive, exergy analysis process is essential for designing highly efficient cryogenic installations. Wzrost zapotrzebowania na gaz ziemny na świecie powoduje, że produkcja skroplonego gazu ziemnego (LNG), a w konsekwencji jego regazyfikacja, staje się coraz bardziej powszechnym procesem związanym z jego transportem. Skroplony gaz transportowany jest w zbiornikach w temperaturze około 111K pod ciśnieniem atmosferycznym. Przebieg procesu regazyfikacji niezbędny do zamiany LNG z fazy ciekłej w gazową dla dalszego transportu w sieci, umożliwia wykorzystanie egzergii LNG do różnych zastosowań, między innymi do produkcji energii elektrycznej. Analiza egzergii jest znaną techniką analizowania nieodwracalnych strat w wydzielonym procesie. Pozwala na określenie dystrybucji, źródła i wielkości nieodwracalnych strat w systemach energetycznych, a więc ustalić wytyczne dotyczące efektywnego zużycia energii. Ponieważ zarówno regazyfikacja LNG jak i skraplanie gazu ziemnego są energochłonne, proces analizy egzergii jest niezbędny do projektowania wysoce wydajnych instalacji kriogenicznych.

LNG systems for natural gas propelled ships

Science.gov (United States)

Chorowski, M.; Duda, P.; Polinski, J.; Skrzypacz, J.

2015-12-01

In order to reduce the atmospheric pollution generated by ships, the International Marine Organization has established Emission Controlled Areas. In these areas, nitrogen oxides, sulphur oxides and particulates emission is strongly controlled. From the beginning of 2015, the ECA covers waters 200 nautical miles from the coast of the US and Canada, the US Caribbean Sea area, the Baltic Sea, the North Sea and the English Channel. From the beginning of 2020, strong emission restrictions will also be in force outside the ECA. This requires newly constructed ships to be either equipped with exhaust gas cleaning devices or propelled with emission free fuels. In comparison to low sulphur Marine Diesel and Marine Gas Oil, LNG is a competitive fuel, both from a technical and economical point of view. LNG can be stored in vacuum insulated tanks fulfilling the difficult requirements of marine regulations. LNG must be vaporized and pressurized to the pressure which is compatible with the engine requirements (usually a few bar). The boil-off must be controlled to avoid the occasional gas release to the atmosphere. This paper presents an LNG system designed and commissioned for a Baltic Sea ferry. The specific technical features and exploitation parameters of the system will be presented. The impact of strict marine regulations on the system's thermo-mechanical construction and its performance will be discussed. The review of possible flow-schemes of LNG marine systems will be presented with respect to the system's cost, maintenance, and reliability.

The importance of LNG for natural gas consumption in the EU

Directory of Open Access Journals (Sweden)

Metelska Klaudia

2016-01-01

Full Text Available The World market of liquefied natural gas (LNG is growing rapidly. In 2015 LNG production exceeded 333 bcm with its predicted increase up to 450 bcm in 2019. The analysis of LNG role in natural gas import to the EU in recent years shows variability: LNG share in overall import reached 25% in 2011 and it went down to 15% in 2014. The smaller demand for natural gas including LNG in the EU can be due to, among others, a slower economic growth and a dynamic development of the use of renewable energy sources. The article shows the role of natural gas in the structure of consumption of primary energy as well as the changes in demand for natural gas in the years 2007–2014 for the main groups of end users: industry, energy production and individual households. The biggest fall in demand for natural gas has been observed in energy production sector in recent years. This publication continues to analyse the structure of natural gas supplies to the EU, with special emphasis on the directions of LNG import to the countries such as: The UK, Spain, France, Greece, Belgium, Portugal, Italy, Lithuania and The Netherlands. The significance of LNG in the balance of consumption of natural gas in these countries has been presented as well as the infrastructure connected with LNG and plans of development of regasification terminals. In the summary the most important conclusions have been drawn and a chance of the increase in significance of the role of LNG in the balance of natural gas supplies has been pointed out, which is due to the steep fall of LNG prices which has taken place in recent years.

LNG trade preparations are a decade too soon

Energy Technology Data Exchange (ETDEWEB)

Timm, S [Mar. Week; Faridany, E; Mitchell, P

1979-03-01

A discussion of papers delivered at the 6th International LNG/LPG, Gastech 78, Conference (Monte Carlo 11/7-10/78) covers an estimate by E. Faridany (Ocean Phoenix Transp. Inc.) that in 1981-85, world trade in LNG would increase by 1775 million cu ft/day (Mcfd) over the current 2720 Mcfd, but of this increment only the 460 Mcfd Panhandle project using Lake Charles, La., as a regasification terminal will be into the U.S. while all other trade will be to Europe. Of the present LNG trade, 48Vertical Bar3< goes to Japan from the Brunei (535 Mcfd, the world's largest) and Abu Dhabi projects, and only 20Vertical Bar3< goes to the U.S. Faridany's estimates of U.S. LNG imports in 1990 vary from the 8215 Mcfd ''high'' to the ''median'' forecast of 2930 Mcfd; he predicted that the proportion of incremental sources of gas supply taken up by LNG in 1990 is only 20-40Vertical Bar3< for the U.S., compared with 25Vertical Bar3< for Europe and 90Vertical Bar3< for Japan. According to P. Mitchell (Poten and Partners), world demand for LPG could rise from 9 million to 38 million tons in 1979-85.

Modeling Turkey’s future LNG supply security strategy

International Nuclear Information System (INIS)

Efe Biresselioglu, Mehmet; Hakan Demir, Muhittin; Kandemir, Cansu

2012-01-01

Turkey was among those countries which decided to increase its natural gas consumption in the 1990s, due to its relative low cost and lack of impact on the environment. However, a heavy dependence on imports, from Algeria, Qatar and Nigeria, respectively, creates a threat to energy security, both in terms of source and supply diversity. Accordingly, we follow an analytical approach to identify the accuracy of our assumption, considering the current economic, political and security risk. To this end, we formulate and solve a mixed integer programming model that determines the optimal sourcing strategy for Turkey’s increasing LNG demand. This model demonstrates a number of alternative policy options for LNG supply. Furthermore, we consider that increasing the proportion of LNG in the overall gas supply will contribute to the aim of improving Turkey’s level of energy security. - Highlights: ► Turkey’s best policy option is to increase the share of LNG. ► Turkey’s main suppliers of LNG will be Algeria, Egypt, Nigeria, and Trinidad and Tobago. ► Norway, Libya, and Oman contribute to the supply with rather smaller shares. ► With high risk scenario Algeria, Egypt, Nigeria and Libya will not be suppliers. ► Oman and Qatar will cover; even though they are high-cost suppliers.

Towards a world development of LNG market

International Nuclear Information System (INIS)

Anon.

2002-01-01

The world development of the LNG trade was the theme of the second workshop of the 7. summit of natural gas industry leaders. With the increasing development of the LNG industry, a world scale natural gas market is becoming possible and should replace the present day regional markets. This article analyzes the expected economic impacts of such a market. (J.S.)

LNG, the way ahead

International Nuclear Information System (INIS)

Chabrelie, M.F.

2007-01-01

Despite the many obstacles producers must overcome, particularly to satisfy demand at the right time, LNG remains the pre-eminent option for ensuring the expansion of the world's gas industry. (author)

The Safety Design Research of a LNG Carrier Vehicle

OpenAIRE

Liang, Yi; Zhou, Xiang

2015-01-01

LNG is the abbreviation for liquefied natural gas, which is recognized as one of the world’s clean energies. LNG is one product at natural gas that through purification and ultra-low temperature is liquefied. The liquefied natural gas is very suitable for LNG transportation by a truck. China is a big country rich in natural resources. The use of natural gas is in favor of Chinese energy structure adjustment. It has important strategic significance to improve the ecological environment and the...

LNG: a commodity in the making

International Nuclear Information System (INIS)

Chabrelie, M.F.

2006-01-01

Although still far from being a commodity, LNG is undoubtedly emerging as an essential vector for world gas expansion. The flexibility it procures in terms of supply is of prime importance for future market equilibrium. Despite a number of uncertainties and constraints liable to thwart the realisation of the most optimistic growth prospects, the LNG trade remains wedded to rapid growth of about 7%/year by 2020, boosting its share of world gas trade to some 38% by that horizon. (author)

LNG: a commodity in the making

Energy Technology Data Exchange (ETDEWEB)

Chabrelie, M.F

2006-07-01

Although still far from being a commodity, LNG is undoubtedly emerging as an essential vector for world gas expansion. The flexibility it procures in terms of supply is of prime importance for future market equilibrium. Despite a number of uncertainties and constraints liable to thwart the realisation of the most optimistic growth prospects, the LNG trade remains wedded to rapid growth of about 7%/year by 2020, boosting its share of world gas trade to some 38% by that horizon. (author)

LNG: a commodity in the making

International Nuclear Information System (INIS)

Chabrelie, M.F.

2006-01-01

Although still far being a commodity, LNG is undoubtedly emerging as an essential vector for world gas expansion. The flexibility it procures in terms of supply is of prime importance for future market equilibrium. Despite a number of uncertainties and constraints liable to thwart the realization of the most optimistic growth prospects, the LNG trade remains wedded to rapid growth of about 7% year by 2020, boosting its share of world gas trade to some 38% by that horizon. (author)

Refloating stranded gas. Floating LNG-factory to become the largest ship on the world seas; Gestrand gas vlot trekken. Drijvende LNG-fabriek wordt grootste schip op wereldzeeen

Energy Technology Data Exchange (ETDEWEB)

De Wit, P.

2010-09-15

Great effort is currently put in the upcoming construction of a gigantic floating LNG plant that will be deployed by Shell. The enormous vessel will be used for the production of gas fields that are so far away from the coast that it is uneconomical to bring the gas to land by means of gas pipes, where it is converted into liquid natural gas (LNG). According to recent plans the first floating LNG plant will be used at the Prelude gas field northwest of Australia. [Dutch] Momenteel wordt hard gewerkt aan de aanstaande bouw van een gigantisch drijvende LNG-fabriek die door Shell ingezet gaat worden. Het enorme vaartuig wordt gebruikt voor de productie van gasvelden die zo ver uit de kust liggen dat het oneconomisch is om het gas met pijpleidingen aan land te brengen om het daar om te zetten in vloeibaar aardgas, LNG. Volgens de huidige plannen wordt de eerste drijvende LNG-fabriek gebruikt voor het Prelude gasveld ten noord-westen van Australie.

LNG demand, shipping will expand through 2010

International Nuclear Information System (INIS)

True, W.R.

1998-01-01

The 1990s, especially the middle years, have witnessed a dramatic turnaround in the growth of liquefied-natural-gas demand which has tracked equally strong natural-gas demand growth. This trend was underscored late last year by several annual studies of world LNG demand and shipping. As 1998 began, however, economic turmoil in Asian financial markets has clouded near-term prospects for LNG in particular and all energy in general. But the extent of damage to energy markets is so far unclear. A study by US-based Institute of Gas Technology, Des Plaines, IL, reveals that LNG imports worldwide have climbed nearly 8%/year since 1980 and account for 25% of all natural gas traded internationally. In the mid-1970s, the share was only 5%. In 1996, the most recent year for which complete data are available, world LNG trade rose 7.7% to a record 92 billion cu m, outpacing the overall consumption for natural gas which increased 4.7% in 1996. By 2015, says the IGT study, natural-gas use would surpass coal as the world''s second most widely used fuel, after petroleum. Much of this growth will occur in the developing countries of Asia where gas use, before the current economic crisis began, was projected to grow 8%/year through 2015. Similar trends are reflected in another study of LNG trade released at year end 1997, this from Ocean Shipping Consultants Ltd., Surrey, U.K. The study was done too early, however, to consider the effects of the financial problems roiling Asia

The stress characteristics of plate-fin structures at the different operation parameters of LNG heat exchanger

Directory of Open Access Journals (Sweden)

Ma Hongqiang

2018-01-01

Full Text Available In this paper, the stresses of plate-fin structures at the different operation parameters were analyzed in actual operation process of LNG plate-fin heat exchanger based on finite element method and thermal elastic theory. Stress characteristics of plate-fin structures were investigated at the different operation parameters of that. The results show that the structural failure of plate-fin structures is mainly induced by the maximum shear stress at the brazing filler metal layer between plate and fin while by the maximum normal stress in the region of brazed joint near the fin side. And a crack would initiate in brazed joint near the fin side. The maximum normal stress is also main factor to result in the structural failure of plate-fin structures at the different temperature difference (between Natural Gas (NG and Mixture Refrigerant (MR, MR temperature and NG pressure of LNG heat exchanger. At the same time, the peak stresses obviously increase as the temperature difference, MR temperature and NG pressure increase. These results will provide some constructive instructions in the safe operation of LNG plate-fin heat exchanger in a large-scale LNG cold-box.

LNG REGASIFICATION TERMINALS ACCESS CAPACITY ANALYSIS FOR SECURITY OF EUROPEAN NATURAL GAS SUPPLY

Directory of Open Access Journals (Sweden)

Matija Veselić

2011-12-01

Full Text Available Increasing natural gas consumption, declining North Sea gas reserves, increased production costs and the deregulation of European gas and electricity markets have all combined to create new opportunities for LNG in Europe. In these circumstances, LNG represents an opportunity for many European countries to diversify their natural gas supply, while decreasing their dependence on Russian natural gas import at the same time. The largest exporters of LNG to Europe are Qatar, Algeria, Nigeria, Trinidad & Tobago, Egypt and Oman. Spain, Great Britain and France are the largest European importers of LNG. Spain has six LNG regasification terminals, followed by four in Great Britain, three in France, two in Italy and Turkey and finally Greece and Portugal with one terminal each. New LNG regasification terminals are currently under construction in Italy, Spain, Sweden and Netherlands. In addition, more than 30 new LNG terminal projects have been proposed around Europe. Italy plans to construct as many as 10 new regasification terminals, due to the strong orientation of its national energy policy towards LNG. Many European countries are strongly considering participating in the LNG chain for the first time, namely Albania, Cyprus, Ireland, Lithuania, Germany, Poland, Romania, Ukraine and Croatia. This paper focuses on a specific aspect of the LNG supply chain: the import facility (the paper is published in Croatian.

Analysis of temperature and pressure changes in liquefied natural gas (LNG) cryogenic tanks

Science.gov (United States)

Chen, Q.-S.; Wegrzyn, J.; Prasad, V.

2004-10-01

Liquefied natural gas (LNG) is being developed as a transportation fuel for heavy vehicles such as trucks and transit buses, to lessen the dependency on oil and to reduce greenhouse gas emissions. The LNG stations are properly designed to prevent the venting of natural gas (NG) from LNG tanks, which can cause evaporative greenhouse gas emissions and result in fluctuations of fuel flow and changes of fuel composition. Boil-off is caused by the heat added into the LNG fuel during the storage and fueling. Heat can leak into the LNG fuel through the shell of tank during the storage and through hoses and dispensers during the fueling. Gas from tanks onboard vehicles, when returned to LNG tanks, can add additional heat into the LNG fuel. A thermodynamic and heat transfer model has been developed to analyze different mechanisms of heat leak into the LNG fuel. The evolving of properties and compositions of LNG fuel inside LNG tanks is simulated. The effect of a number of buses fueled each day on the possible total fuel loss rate has been analyzed. It is found that by increasing the number of buses, fueled each day, the total fuel loss rate can be reduced significantly. It is proposed that an electric generator be used to consume the boil-off gas or a liquefier be used to re-liquefy the boil-off gas to reduce the tank pressure and eliminate fuel losses. These approaches can prevent boil-off of natural gas emissions, and reduce the costs of LNG as transportation fuel.

Thermodynamic and heat transfer analysis of LNG energy recovery for power production

International Nuclear Information System (INIS)

Franco, A; Casarosa, C

2014-01-01

An important option to transport the gas is to convert it into liquid natural gas (LNG) and convey it using insulated LNG tankers. At receiving terminals, the LNG is offloaded into storage tanks and then pumped at the required pressure and vaporized for final transmission to the pipeline. The LNG production process consumes a considerable amount of energy, while the cold availability, as also known as cold energy, has been stored in LNG. At a receiving terminal, LNG needs to be evaporated into gas at environmental temperature before fed into the gas distribution system. Seawater is commonly used for the regasification process of the LNG. In the present paper, after a general analysis of the perspectives of the various thermodynamic schemes proposed for power production from the regasification, a detailed analysis of enhanced direct expansion system is carried out in order to identify the upper level of the energy that can be recovered. The analysis outlines that power production typical of optimized ORC plant configurations (120 kJ/kg) can be obtained with direct expansion solutions

Thermodynamic and heat transfer analysis of LNG energy recovery for power production

Science.gov (United States)

Franco, A.; Casarosa, C.

2014-11-01

An important option to transport the gas is to convert it into liquid natural gas (LNG) and convey it using insulated LNG tankers. At receiving terminals, the LNG is offloaded into storage tanks and then pumped at the required pressure and vaporized for final transmission to the pipeline. The LNG production process consumes a considerable amount of energy, while the cold availability, as also known as cold energy, has been stored in LNG. At a receiving terminal, LNG needs to be evaporated into gas at environmental temperature before fed into the gas distribution system. Seawater is commonly used for the regasification process of the LNG. In the present paper, after a general analysis of the perspectives of the various thermodynamic schemes proposed for power production from the regasification, a detailed analysis of enhanced direct expansion system is carried out in order to identify the upper level of the energy that can be recovered. The analysis outlines that power production typical of optimized ORC plant configurations (120 kJ/kg) can be obtained with direct expansion solutions.

The LNG Industry - 2012

International Nuclear Information System (INIS)

2013-04-01

The 2011 catastrophic tsunami in Japan continued its grip on LNG flows throughout 2012, causing massive shifts eastwards of Atlantic Basin and Middle East-sourced cargoes to satisfy the strong demand of Japan's power industry. Its commercial effects are likely to continue beyond the current year as well as beyond a mere diversion of product flows. On the production side, capacity additions have been below expectations and insufficient to make up for the higher loss of capacity due to planned shutdowns and unscheduled production interruptions, mainly resulting from a shortfall of feed-gas. As a result, in 2012, LNG trade has seen the first decline (minus 1.9%) in the past thirty years. The strong growth in spot and short term trade seen in recent years (up by 110% from 2009 to 2011) is no longer there, primarily, but not solely, in line with the lack of new supplies. Undoubtedly, the conversion of non-committed production and flexible supplies and of so-called wedge cargoes -especially from Qatar and Peru- into term volumes has reduced the overall short term liquidity. Until substantial new volumes become available, this phenomenon is likely to continue for the next couple of years as Asian importers have a growing appetite for (more) secure supplies. Two events in 2012, albeit of a different nature, stand out among the highlights of the year: a significant rise in reloads, and the first final investment decision (FID) of exports from North America. Reloading of cargoes in receiving terminals is generally presented as a demonstration of commercial innovation though sometimes simply allowing to overcome destination restrictions or difficult negotiations on profit sharing from cargo deviations. Considering operational cost efficiency and the environmental impact, it is doubtful that reloads will continue to be a growing feature in LNG trading, despite a total count in 2012 of 70 re-exported cargoes actually discharged in 2012 (up 60% from last year). It is

Challenges of LNG (Liquefied Natural Gas Carriers in 21" Century

Directory of Open Access Journals (Sweden)

Marina Zanne

2009-01-01

Full Text Available Natural gas is relatively cheap, environmentally friendlyand energetically efficient fossil fuel that is gaining in attractivenessdaily as it can be used in many sectors. As not all consumerscan be reached by pipelines the technique of transp01tingnatural gas in the liquefied form has been developed at the beginningof 20th century but it was only in 1959 that the firstoverseas transport of liquefied natural gas ( LN G occurred. Inthe fifty years of operation LNG shipping has shown immaculatesafety records. LNG tankers can be described only in superlatives;they are without any doubt the most sophisticated and·expensive ships that sail around the globe, they demand specialattention when navigating to or out of harbours and need to bemanned with the most educated and experienced crew. LNGmarket is expanding and changing; demand is surpassing theproductivity, new importing and exporting countries appear,LNG fleet is growing in capacity and number at high pace, exploitationcontracts for the ships are being modified giving theopportunity for new companies to enter( . .. . The paper givesan overview on liquefied natural gas market and the historic developmentof LNG shipping. It focuses on the recent boom inLNG shipping and emphasises questions concerning the safety,crewing and exploitation of the LNG tankers in the future.

Maritime prerequisites for development of infrastructure for liquefied natural gas (LNG / LBG); Maritima foerutsaettningar foer utbyggnad av infrastruktur foer flytande gas (LNG/LBG)

Energy Technology Data Exchange (ETDEWEB)

Gahnstroem, Johan; Molitor, Edvard; Raggl, Karl-Johan; Sandkvist, Jim [SSPA Sweden AB, Goeteborg (Sweden)

2011-06-15

This study has provided an initial picture of where the most interesting ports and areas available for future expansion of a maritime infrastructure for LNG. On the basis of supplying vessels with LNG as fuel, from a long term perspective, we recommend locating LNG terminals in or near major ports and around the big ship routes. Given the current age distribution of ships operating waters of the Baltic Sea, almost 20% of the vessels are 30-40 years old and likely to be replaced by 2015 - 2020. Thus, there is a potential for newly built ships will be equipped with LNG operation. Selected criteria s; Size of the LNG terminal and hence the need for the size of the fairway and the area of land. Proximity to traffic routes with much ship traffic. Proximity to the major port. Proximity to consumers on the land side. On the basis of selected criteria and analyzed for possible location of the terminal it can be noted that a number of Swedish ports are found suitable. For example, ports of Sundsvall, Gothenburg and Helsingborg has been identified as suitable, but with different starting point and different types and sizes of terminals possible.

The LNG Industry in 2011

International Nuclear Information System (INIS)

Robin, Jean-Yves; Demoury, Vincent; Vermeire, Jean

2012-01-01

The most significant event to mark the LNG trade in 2011 has been the catastrophe that hit Japan in March, in view of both its short-term effect on shifting flows and its long-term demand prospects of LNG as a source for gas-fired power generation. The role of LNG as a flexible and secure energy source as well as the prompt response to provide back-up through additional supplies and cargo diversions to compensate for the sudden loss of nuclear capacity in Japan - with sellers exercising due price restraint in view of the human tragedy - has been a credit to the industry. The increase in production capacity in 2009 and 2010, in particular from Qatar, had permitted the necessary buffer to cope much better with the demand surge than during past disruptions (such as the aftermath of the Chuetsu earthquake in late 2007). Undoubtedly, the marked shift over the last decade in the industry's prevailing business model towards global trade, destination flexibility and portfolio play has also facilitated the rapid response. As the total volume of LNG trade is very much determined by the availability of supply, 2011 has seen a growth of 9.4% over 2010, mainly as a result of the full availability of the six Qatar mega-trains over the past year. On the demand side the two traditional basins have shown a very contrasting trend: 15% higher LNG off-take in Asia (the five major markets all increasing between 37.4% and 8.9%), versus a 1.7% decrease in the Atlantic Basin. Cargo diversions and an increasing number of reloads have boosted the exports from the Atlantic Basin to Asia in 2011 to more than 14 million tons (equivalent to more than 200 large size cargoes). Remarkable is also the fast growth in new markets in Latin America and in the Middle East - albeit from a small base - with counter-seasonal but varying demand, offering attractive arbitrage opportunities to portfolio play. Not surprising then that 2011 has seen another hike in spot and short-term trade, not just in

LNG pool fire spectral data and calculation of emissive power

International Nuclear Information System (INIS)

Raj, Phani K.

2007-01-01

Spectral description of thermal emission from fires provides a fundamental basis on which the fire thermal radiation hazard assessment models can be developed. Several field experiments were conducted during the 1970s and 1980s to measure the thermal radiation field surrounding LNG fires. Most of these tests involved the measurement of fire thermal radiation to objects outside the fire envelope using either narrow-angle or wide-angle radiometers. Extrapolating the wide-angle radiometer data without understanding the nature of fire emission is prone to errors. Spectral emissions from LNG fires have been recorded in four test series conducted with LNG fires on different substrates and of different diameters. These include the AGA test series of LNG fires on land of diameters 1.8 and 6 m, 35 m diameter fire on an insulated concrete dike in the Montoir tests conducted by Gaz de France, a 1976 test with 13 m diameter and the 1980 tests with 10 m diameter LNG fire on water carried out at China Lake, CA. The spectral data from the Montoir test series have not been published in technical journals; only recently has some data from this series have become available. This paper presents the details of the LNG fire spectral data from, primarily, the China Lake test series, their analysis and results. Available data from other test series are also discussed. China Lake data indicate that the thermal radiation emission from 13 m diameter LNG fire is made up of band emissions of about 50% of energy by water vapor (band emission), about 25% by carbon dioxide and the remainder constituting the continuum emission by luminous soot. The emissions from the H 2 O and CO 2 bands are completely absorbed by the intervening atmosphere in less than about 200 m from the fire, even in the relatively dry desert air. The effective soot radiation constitutes only about 23% during the burning period of methane and increases slightly when other higher hydrocarbon species (ethane, propane, etc.) are

77 FR 76013 - Sempra LNG Marketing, LLC; Application for Blanket Authorization To Export Previously Imported...

Science.gov (United States)

2012-12-26

... marketing supplies of LNG. Sempra is a customer of the Cameron Terminal. On June 22, 2012, FE issued DOE/FE... DEPARTMENT OF ENERGY [FE Docket No. 12-155-LNG] Sempra LNG Marketing, LLC; Application for Blanket..., by Sempra LNG Marketing, LLC (Sempra LNG Marketing), requesting blanket authorization to export...

Logistics and supply chain effectiveness measure areas in lng companies

Directory of Open Access Journals (Sweden)

2010-09-01

Full Text Available The article describes the issues of logistics and supply chain measures in companies. It considers different management systems in the area of production, which evolved from isolated production activities to business connected systems. There are performed three case studies - three examples of systems proposed and implemented in the LNG industry: I-MAC, ICIMS and PMS. Data gained from these systems are the basis to create effectiveness measures for LNG companies and LNG supply chains.

Overview study of LNG release prevention and control systems

Energy Technology Data Exchange (ETDEWEB)

Pelto, P.J.; Baker, E.G.; Holter, G.M.; Powers, T.B.

1982-03-01

The liquefied natural gas (LNG) industry employs a variety of release prevention and control techniques to reduce the likelihood and the consequences of accidental LNG releases. A study of the effectiveness of these release prevention and control systems is being performed. Reference descriptions for the basic types of LNG facilities were developed. Then an overview study was performed to identify areas that merit subsequent and more detailed analyses. The specific objectives were to characterize the LNG facilities of interest and their release prevention and control systems, identify possible weak links and research needs, and provide an analytical framework for subsequent detailed analyses. The LNG facilities analyzed include a reference export terminal, marine vessel, import terminal, peakshaving facility, truck tanker, and satellite facility. A reference description for these facilities, a preliminary hazards analysis (PHA), and a list of representative release scenarios are included. The reference facility descriptions outline basic process flows, plant layouts, and safety features. The PHA identifies the important release prevention operations. Representative release scenarios provide a format for discussing potential initiating events, effects of the release prevention and control systems, information needs, and potential design changes. These scenarios range from relatively frequent but low consequence releases to unlikely but large releases and are the principal basis for the next stage of analysis.

Assessing integrity and realiability of multicomposite LNG transfer hoses

NARCIS (Netherlands)

Weijde, G.D. van der; Putten, S. van der

2012-01-01

Reliable transfer systems are a key element in developing floating LNG and the small scale LNG market. Multi-composite hoses may prove to be a reliable and cost effective solution for offshore, near- and on-shore applications. TNO, the Dutch contract research organization, has executed an extensive

The role of Liquefied Natural Gas (LNG) in the European gas market

International Nuclear Information System (INIS)

Mahan, A.

2003-06-01

The purpose of this paper is to discuss the role that Liquefied Natural Gas (LNG) might play in the future EU gas market. LNG imports are not likely to have a place in the Netherlands soon, but they could make an important contribution to the volume and diversity of Europe's gas supplies. An important characteristic of LNG is its inherently high costs, throughout the whole chain, from the wellhead to the market. These costs are considerably higher than the costs of bringing oil to the market. Cost considerations, in combination with the rigidity of the gas market, have led to the use of long-term contracts as a basis for the business, as is the case for the long haul pipeline gas business. Costs have come down considerably and further cost reductions are 'in the pipeline'. While this does not alter the fundamentals of the business it has nonetheless helped to extend the reach of LNG. LNG from the Middle East to Europe has now become economically feasible. The high gas prices of recent years have further fuelled the expansion of the LNG business. Supported by a rapidly growing global economy at the turn of this century, many prospects are under development. The positive economic outlook has seen more speculative positioning in every segment of the LNG chain, while more vertical integration has been industry's response to market liberalisation. The more recent slowdown of the market economies has created a surplus of LNG, which is finding its way onto the markets through short-term and spot transactions. The short-term business will grow over the next few years as more LNG and shipping capacity comes on-stream. However, given underlying high costs and limited flexibility, it should be expected that new projects, currently under consideration, will only be developed on the basis of long-term contracts, thus returning to a balance between supply and demand. For these same reasons, LNG will not likely develop the same the liquidity as that of the oil market. The global

Guanabara Bay and Pecem LNG flexible metering systems

Energy Technology Data Exchange (ETDEWEB)

Torres, Vinicus Roberto C.; Carvalho, Gustavo L.A.; Bruel, Edson L.; Santana, Jose P.C. de; Vidal, Lud C.C.N. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

2009-12-19

This work presents to the community the metering systems installed in the Liquefied Natural (LNG) Gas Flexible Terminals of the Pecem Port and Guanabara Bay. A brief description of the Terminals facilities and its operation is firstly made to provide a background of the systems discussed. Then, the LNG custody transfer metering system, the operational control metering system, the energy balance of the LNG transferring system and the Natural Gas custody transfer metering system - that are our systems of interest - are described in detail. It is intended to use the philosophy adopted in the Guanabara Bay and Pecem Flexible Terminals design as a standard to future installations, integrated with improvements brought by the operation experience that will be obtained in those terminals. (author)

Study on Calculation of Liquid Level And Storage of Tanks for LNG-fueled Vessels

Science.gov (United States)

Li, Kun; Wang, Guoqing; Liu, Chang

2018-01-01

As the ongoing development of the application of LNG as a clean energy in waterborne transport industry, the fleet scale of LNG-fueled vessels enlarged and the safety operation has attracted more attention in the industry. Especially the accurate detection of liquid level of LNG tanks is regarded as an important issue to ensure a safe and stable operation of LNG-fueled ships and a key parameter to keep the proper functioning of marine fuel storage system, supply system and safety control system. At present, detection of LNG tank liquid level mainly adopts differential pressure detection method. Liquid level condition could be found from the liquid level reference tables. However in practice, since LNG-fueled vessels are generally not in a stationary state, liquid state within the LNG tanks will constantly change, the detection of storage of tanks only by reference to the tables will cause deviation to some extent. By analyzing the temperature under different pressure, the effects of temperature change on density and volume integration calculation, a method of calculating the liquid level and storage of LNG tanks is put forward making the calculation of liquid level and actual storage of LNG tanks more accurately and providing a more reliable basis for the calculation of energy consumption level and operation economy for LNG-fueled vessels.

Spot sale of uncommitted LNG from Middle East: Japan or the UK?

International Nuclear Information System (INIS)

Nikhalat-Jahromi, Hamed; Bell, Michael G.H.; Fontes, Dalila B.M.M.; Cochrane, Robert A.; Angeloudis, Panagiotis

2016-01-01

The importance of liquefied natural gas (LNG) is rising as demand for it grows rapidly and steadily due to growth in energy demand, the transition to a low carbon economy and the longer distances over which natural gas is now traded. Given its importance, this work proposes an optimization model that assists to decide on when and where LNG should be delivered by coordinating tanker type, assignment and routing, inventory management, contract obligations, arbitrage and uncommitted LNG. The model maximizes the profit mainly by taking advantage of price differences between different markets. The contributions of this work are twofold. First, following the analysis of expenses and revenues, a new mixed integer programming model for LNG liquefaction and shipping is proposed from a corporate finance perspective. Furthermore, a solution approach for it is implemented and tested. Second, the model is used to derive a short term trade policy for the Middle Eastern LNG producers regarding the spot sale of their uncommitted product to Japan or to the UK, namely to: dispatch to whichever market has the higher current spot price, regardless of the variability of the transport expenses. - Highlights: •The cash-flow of an LNG producer in operational planning is examined. •An LNG inventory routing problem for EBITDA maximization is formulated. •A project in Middle East for studying the spot sale of uncommitted LNG is created. •In sale to Japan and the UK the market with the higher price should be picked.

A dispersion safety factor for LNG vapor clouds

Energy Technology Data Exchange (ETDEWEB)

Vílchez, Juan A. [TIPs – Trámites, Informes y Proyectos, SL, Llenguadoc 10, 08030 Barcelona (Spain); Villafañe, Diana [Centre d’Estudis del Risc Tecnològic (CERTEC), Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Catalonia (Spain); Casal, Joaquim, E-mail: joaquim.casal@upc.edu [Centre d’Estudis del Risc Tecnològic (CERTEC), Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Catalonia (Spain)

2013-02-15

Highlights: ► We proposed a new parameter: the dispersion safety factor (DSF). ► DSF is the ratio between the distance reached by the LFL and that reached by the visible cloud. ► The results for the DSF agree well with the evidence from large scale experiments. ► Two expressions have been proposed to calculate DSF as a function of H{sub R}. ► The DSF may help in indicating the danger of ignition of a LNG vapor cloud. -- Abstract: The growing importance of liquefied natural gas (LNG) to global energy demand has increased interest in the possible hazards associated with its storage and transportation. Concerning the event of an LNG spill, a study was performed on the relationship between the distance at which the lower flammability limit (LFL) concentration occurs and that corresponding to the visible contour of LNG vapor clouds. A parameter called the dispersion safety factor (DSF) has been defined as the ratio between these two lengths, and two expressions are proposed to estimate it. During an emergency, the DSF can be a helpful parameter to indicate the danger of cloud ignition and flash fire.

A dispersion safety factor for LNG vapor clouds

International Nuclear Information System (INIS)

Vílchez, Juan A.; Villafañe, Diana; Casal, Joaquim

2013-01-01

Highlights: ► We proposed a new parameter: the dispersion safety factor (DSF). ► DSF is the ratio between the distance reached by the LFL and that reached by the visible cloud. ► The results for the DSF agree well with the evidence from large scale experiments. ► Two expressions have been proposed to calculate DSF as a function of H R . ► The DSF may help in indicating the danger of ignition of a LNG vapor cloud. -- Abstract: The growing importance of liquefied natural gas (LNG) to global energy demand has increased interest in the possible hazards associated with its storage and transportation. Concerning the event of an LNG spill, a study was performed on the relationship between the distance at which the lower flammability limit (LFL) concentration occurs and that corresponding to the visible contour of LNG vapor clouds. A parameter called the dispersion safety factor (DSF) has been defined as the ratio between these two lengths, and two expressions are proposed to estimate it. During an emergency, the DSF can be a helpful parameter to indicate the danger of cloud ignition and flash fire

Exergetic Analysis, Optimization and Comparison of LNG Cold Exergy Recovery Systems for Transportation

Directory of Open Access Journals (Sweden)

Paweł Dorosz

2018-01-01

Full Text Available LNG (Liquefied Natural Gas shares in the global energy market is steadily increasing. One possible application of LNG is as a fuel for transportation. Stricter air pollution regulations and emission controls have made the natural gas a promising alternative to liquid petroleum fuels, especially in the case of heavy transport. However, in most LNG-fueled vehicles, the physical exergy of LNG is destroyed in the regasification process. This paper investigates possible LNG exergy recovery systems for transportation. The analyses focus on “cold energy” recovery systems as the enthalpy of LNG, which may be used as cooling power in air conditioning or refrigeration. Moreover, four exergy recovery systems that use LNG as a low temperature heat sink to produce electric power are analyzed. This includes single-stage and two-stage direct expansion systems, an ORC (Organic Rankine Cycle system, and a combined system (ORC + direct expansion. The optimization of the above-mentioned LNG power cycles and exergy analyses are also discussed, with the identification of exergy loss in all components. The analyzed systems achieved exergetic efficiencies in the range of 20 % to 36 % , which corresponds to a net work in the range of 214 to 380 kJ/kg L N G .

75 FR 51989 - Southern LNG Company, L.L.C.; Notice of Application

Science.gov (United States)

2010-08-24

... Company, L.L.C.; Notice of Application August 16, 2010. Take notice that on August 4, 2010, Southern LNG Company, L.L.C. (Southern LNG), Post Office Box 2563, Birmingham, Alabama 35202-2563, filed in the above.... Sheffield, Director--Rates and Regulatory, Southern LNG Company, L.L.C., 569 Brookwood Village, Suite 501...

Increased LNG into North America may threaten northern/Arctic gas development

International Nuclear Information System (INIS)

Howard, P.

2006-01-01

Since 2000, liquefied natural gas (LNG) has attracted considerable attention in response to record high price, high demand and tight supply of natural gas. LNG trade is expected to be 18 per cent of North American gas supply by 2020. The natural gas market is also affected by demand dominated by gas-fired power generation. The balance between supply and demand, combined with external factors of economic upsets and weather, has resulted in a volatile market place. LNG can currently be landed in North American at prices that compete with the average continental well head price. In January 2006, there were more than 60 competing LNG regasification projects proposed to access the North American gas market. This presentation listed the proposed facilities to import LNG and emphasized the need for a comprehensive analysis of gas development, given the degree of uncertainty regarding significant investment in gas supply, demand, pipelines and LNG projects. While only a few of the proposed projects will actually be constructed, they will more than double the existing output by 2010. The many possible changes in regional marketplace conditions were discussed with particular attention to the effects on the economic viability of natural gas developments; the impacts of LNG imports on capacities and flows in natural gas pipeline corridors; and, the influence of increased natural gas supplies on local and regional prices. It was noted that since conventional resources in Canada and the United States have reached a plateau, the next logical supply sources are Alaska, the Beaufort Sea, the Mackenzie Delta and the Arctic Islands. However, the development of northern and Arctic gas resources may be delayed if the level of LNG imports is sufficient to fill the deficiency in supply and demand. tabs., figs

Raley's LNG Truck Site Final Data Report

Energy Technology Data Exchange (ETDEWEB)

Battelle

1999-07-01

Raley's is a 120-store grocery chain with headquarters in Sacramento, California, that has been operating eight heavy-duty LNG trucks (Kenworth T800 trucks with Cummins L10-300G engines) and two LNG yard tractors (Ottawa trucks with Cummins B5.9G engines) since April 1997. This report describes the results of data collection and evaluation of the eight heavy-duty LNG trucks compared to similar heavy-duty diesel trucks operating at Raley's. The data collection and evaluation are a part of the U.S. Department of Energy (DOE)/National Renewable Energy Laboratory (NREL) Alternative Fuel Truck Evaluation Project.

LNG ventures raise economic, technical, partnership issues

International Nuclear Information System (INIS)

Acord, H.K.

1995-01-01

The author feels that natural gas will remain a competitive energy alternative and the preferred fuel for many residential and industrial customers around the globe. The article attempts to explain where liquefied natural gas will fit into the global picture. The paper discusses the growth in the Asia-Pacific region; the complex interactions in a LNG project involving buyers, sellers, governments, financial institutions, and shipping companies; the cost of development of such projects; and the elements of a LNG venture

Implementation of the HNS Convention in the LNG Industry: Singularities, Stakes, Issues and GIIGNL Proposed Solutions

International Nuclear Information System (INIS)

2008-01-01

The International Group of Liquefied Natural Gas Importers (GIIGNL) is a non-profit organization founded in December of 1971. It is composed of 56 member companies from 18 different countries across the world and involved in the importation of Liquefied Natural Gas. The main objective of the GIIGNL is to promote the development of activities related to LNG: purchasing, importing, processing, transportation, handling, re-gasification and various uses of LNG. For this purpose, the GIIGNL is particularly involved in promoting the state-of-the art technology in the LNG industry, in communicating about the economic fundamentals of the industry, in enhancing facility operations, in diversifying contractual techniques, and in developing industry positions to be taken in international agencies. As a member of the IOPC Fund since June 2007, the GIIGNL prepared this LNG overview in order to offer a better understanding to state delegations about this specific product and its market and to contribute to the debate on the implementation of the HNS Convention. the first chapter constitutes an introduction to the LNG Industry: presentation of an LNG Chain, overview of the global LNG trade and its growth rate, type of contracts, LNG tankers and technical transportation constraints, liquefaction and re-gasification plants around the world. The second chapter focuses on some singularities of the LNG industry that differentiate LNG from other Hazardous and Noxious Substances: LNG, a clean and unique product and activity, high standards and firm regulations concerning security and maritime safety, high level of investment required for an LNG chain, DES and FOB, the fundamental Incoterms of LNG sales and purchase. The third chapter presents the HNS Convention as potentially applicable to the LNG market: a two tier compensation regime - a new perspective for the LNG industry, a potential impact on LNG sales and purchase agreements, the importance of global HNS ratification within LNG

A NOVEL PROCESS TO USE SALT CAVERNS TO RECEIVE SHIP BORNE LNG

Energy Technology Data Exchange (ETDEWEB)

Michael M. McCall; William M. Bishop; Marcus Krekel; James F. Davis; D. Braxton Scherz

2005-05-31

This cooperative research project validates use of man made salt caverns to receive and store the cargoes of LNG ships in lieu of large liquid LNG tanks. Salt caverns will not tolerate direct injection of LNG because it is a cryogenic liquid, too cold for contact with salt. This research confirmed the technical processes and the economic benefits of pressuring the LNG up to dense phase, warming it to salt compatible temperatures and then directly injecting the dense phase gas into salt caverns for storage. The use of salt caverns to store natural gas sourced from LNG imports, particularly when located offshore, provides a highly secure, large scale and lower cost import facility as an alternative to tank based LNG import terminals. This design can unload a ship in the same time as unloading at a tank based terminal. The Strategic Petroleum Reserve uses man made salt caverns to securely store large quantities of crude oil. Similarly, this project describes a novel application of salt cavern gas storage technologies used for the first time in conjunction with LNG receiving. The energy industry uses man made salt caverns to store an array of gases and liquids but has never used man made salt caverns directly in the importation of LNG. This project has adapted and expanded the field of salt cavern storage technology and combined it with novel equipment and processes to accommodate LNG importation. The salt cavern based LNG receiving terminal described in the project can be located onshore or offshore, but the focus of the design and cost estimates has been on an offshore location, away from congested channels and ports. The salt cavern based terminal can provide large volumes of gas storage, high deliverability from storage, and is simplified in operation compared to tank based LNG terminals. Phase I of this project included mathematical modeling that proved a salt cavern based receiving terminal could be built at lower capital cost, and would have significantly higher

Developments in the safe design of LNG tanks

Science.gov (United States)

Fulford, N. J.; Slatter, M. D.

The objective of this paper is to discuss how the gradual development of design concepts for liquefied natural gas (LNG) storage systems has helped to enhance storage safety and economy. The experience in the UK is compared with practice in other countries with similar LNG storage requirements. Emphasis is placed on the excellent record of safety and reliability exhibited by tanks with a primary metal container designed and constructed to approved standards. The work carried out to promote the development of new materials, fire protection, and monitoring systems for use in LNG storage is also summarized, and specific examples described from British Gas experience. Finally, the trends in storage tank design world-wide and options for future design concepts are discussed, bearing in mind planned legislation and design codes governing hazardous installations.

Waste Management's LNG Truck Fleet: Final Results

Energy Technology Data Exchange (ETDEWEB)

Chandler, K. [Battelle (US); Norton, P. [National Renewable Energy Laboratory (US); Clark, N. [West Virginia University (US)

2001-01-25

Waste Management, Inc., began operating a fleet of heavy-duty LNG refuse trucks at its Washington, Pennsylvania, facility. The objective of the project was to provide transportation professionals with quantitative, unbiased information on the cost, maintenance, operational, and emissions characteristics of LNG as one alternative to conventional diesel for heavy-duty trucking applications.

LNG Safety Assessment Evaluation Methods

Energy Technology Data Exchange (ETDEWEB)

Muna, Alice Baca [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); LaFleur, Angela Christine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-05-01

Sandia National Laboratories evaluated published safety assessment methods across a variety of industries including Liquefied Natural Gas (LNG), hydrogen, land and marine transportation, as well as the US Department of Defense (DOD). All the methods were evaluated for their potential applicability for use in the LNG railroad application. After reviewing the documents included in this report, as well as others not included because of repetition, the Department of Energy (DOE) Hydrogen Safety Plan Checklist is most suitable to be adapted to the LNG railroad application. This report was developed to survey industries related to rail transportation for methodologies and tools that can be used by the FRA to review and evaluate safety assessments submitted by the railroad industry as a part of their implementation plans for liquefied or compressed natural gas storage ( on-board or tender) and engine fueling delivery systems. The main sections of this report provide an overview of various methods found during this survey. In most cases, the reference document is quoted directly. The final section provides discussion and a recommendation for the most appropriate methodology that will allow efficient and consistent evaluations to be made. The DOE Hydrogen Safety Plan Checklist was then revised to adapt it as a methodology for the Federal Railroad Administration’s use in evaluating safety plans submitted by the railroad industry.

Life-cycle greenhouse gas analysis of LNG as a heavy vehicle fuel in Europe

International Nuclear Information System (INIS)

Arteconi, A.; Brandoni, C.; Evangelista, D.; Polonara, F.

2010-01-01

The aim of the present study was to compare the life cycle, in terms of greenhouse gas (GHG) emissions, of diesel and liquefied natural gas (LNG) used as fuels for heavy-duty vehicles in the European market (EU-15). A literature review revealed that the numerous studies conducted have reported different results when the authors departed from different baseline assumptions and reference scenarios. For our study, we concentrated on the European scenario and on heavy-duty road transport vehicles, given their important incidence on the global emissions of GHG. Two possible LNG procurement strategies were considered i.e. purchasing it directly from the regasification terminal (LNG-TER) or producing LNG locally (at the service station) with small-scale plants (LNG-SSL). We ascertained that the use of LNG-TER enables a 10% reduction in GHG emissions by comparison with diesel, while the emissions resulting from the LNG-SSL solution are comparable with those of diesel.

Life-cycle greenhouse gas analysis of LNG as a heavy vehicle fuel in Europe

Energy Technology Data Exchange (ETDEWEB)

Arteconi, A.; Brandoni, C.; Evangelista, D.; Polonara, F. [Universita Politecnica delle Marche, Dipartimento di Energetica, Via Brecce Bianche, 1-60131 Ancona (Italy)

2010-06-15

The aim of the present study was to compare the life cycle, in terms of greenhouse gas (GHG) emissions, of diesel and liquefied natural gas (LNG) used as fuels for heavy-duty vehicles in the European market (EU-15). A literature review revealed that the numerous studies conducted have reported different results when the authors departed from different baseline assumptions and reference scenarios. For our study, we concentrated on the European scenario and on heavy-duty road transport vehicles, given their important incidence on the global emissions of GHG. Two possible LNG procurement strategies were considered i.e. purchasing it directly from the regasification terminal (LNG-TER) or producing LNG locally (at the service station) with small-scale plants (LNG-SSL). We ascertained that the use of LNG-TER enables a 10% reduction in GHG emissions by comparison with diesel, while the emissions resulting from the LNG-SSL solution are comparable with those of diesel. (author)

Drug-induced hepatic injury

DEFF Research Database (Denmark)

Friis, Henrik; Andreasen, P B

1992-01-01

The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.......5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.......7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected...

Future of gas. LNG between feast and famine

Energy Technology Data Exchange (ETDEWEB)

Forbes, A.

2009-05-15

Between now and 2012, a new wave of LNG (liquid natural gas) supply will wash over markets, with Qatar accounting for half the growth as six new 'mega-trains' come on stream. It will arrive just as gas demand is being hit by the economic crisis. Beyond 2012, the situation will reverse, with growth constrained by lack of new supply. The LNG industry is facing a turbulent decade.

Evolving framework of the LNG industry: Expected growth and continuing importance of safety

International Nuclear Information System (INIS)

Kagiyama, Ichiro

1992-01-01

A major increase in LNG trade, expected from the 1990s onwards, is quite significant in that a new framework will be developed. These changes and developments may well prove to be some of the most notable that have ever occurred in the 30-year history of the LNG industry. All over the world, new buyers and sellers are entering the scene, while in Japan, small and medium-size businesses are switching to LNG. Transporters and LNG carriers are also expecting an increase in their numbers. We are about to see a wide-ranging diversification in terms of the geography and the size of the companies that deal with LNG. Safety continues to be the main issue in promoting the development of the LNG market. The wider the spread of LNG, the greater the need will be for further development of the systems and organizations for transferring safety technology and skills. In addition to enhancing safety, it will be necessary to seek harmony with the social environment. This paper discusses measures for the future based on the author's many years of experience, particularly in the field of receiving terminals

Hawaii energy strategy project 2: Fossil energy review. Task 3 -- Greenfield options: Prospects for LNG use

Energy Technology Data Exchange (ETDEWEB)

Breazeale, K. [ed.; Fesharaki, F.; Fridley, D.; Pezeshki, S.; Wu, K.

1993-12-01

This paper begins with an overview of the Asia-Pacific LNG market, its major players, and the likely availability of LNG supplies in the region. The discussion then examines the possibilities for the economic supply of LNG to Hawaii, the potential Hawaiian market, and the viability of an LNG project on Oahu. This survey is far from a complete technical assessment or an actual engineering/feasibility study. The economics alone cannot justify LNG`s introduction. The debate may continue as to whether fuel diversification and environmental reasons can outweigh the higher costs. Several points are made. LNG is not a spot commodity. Switching to LNG in Hawaii would require a massive, long-term commitment and substantial investments. LNG supplies are growing very tight in the Asia-Pacific region. Some of the environmental benefits of LNG are not entirely relevant in Hawaii because Hawaii`s air quality is generally excellent. Any air quality benefits may be more than counterbalanced by the environmental hazards connected with large-scale coastal zone construction, and by the safety hazards of LNG carriers, pipelines, etc. Lastly, LNG is not suitable for all energy uses, and is likely to be entirely unsuitable for neighbor island energy needs.

Investigation of propulsion system for large LNG ships

International Nuclear Information System (INIS)

Sinha, R P; Wan Nik, Wan Mohd Norsani

2012-01-01

Requirements to move away from coal for power generation has made LNG as the most sought after fuel source, raising steep demands on its supply and production. Added to this scenario is the gradual depletion of the offshore oil and gas fields which is pushing future explorations and production activities far away into the hostile environment of deep sea. Production of gas in such environment has great technical and commercial impacts on gas business. For instance, laying gas pipes from deep sea to distant receiving terminals will be technically and economically challenging. Alternative to laying gas pipes will require installing re-liquefaction unit on board FPSOs to convert gas into liquid for transportation by sea. But, then because of increased distance between gas source and receiving terminals the current medium size LNG ships will no longer remain economical to operate. Recognizing this business scenario shipowners are making huge investments in the acquisition of large LNG ships. As power need of large LNG ships is very different from the current small ones, a variety of propulsion derivatives such as UST, DFDE, 2-Stroke DRL and Combined cycle GT have been proposed by leading engine manufacturers. Since, propulsion system constitutes major element of the ship's capital and life cycle cost, which of these options is most suited for large LNG ships is currently a major concern of the shipping industry and must be thoroughly assessed. In this paper the authors investigate relative merits of these propulsion options against the benchmark performance criteria of BOG disposal, fuel consumption, gas emissions, plant availability and overall life cycle cost.

Investigation of propulsion system for large LNG ships

Science.gov (United States)

Sinha, R. P.; Nik, Wan Mohd Norsani Wan

2012-09-01

Requirements to move away from coal for power generation has made LNG as the most sought after fuel source, raising steep demands on its supply and production. Added to this scenario is the gradual depletion of the offshore oil and gas fields which is pushing future explorations and production activities far away into the hostile environment of deep sea. Production of gas in such environment has great technical and commercial impacts on gas business. For instance, laying gas pipes from deep sea to distant receiving terminals will be technically and economically challenging. Alternative to laying gas pipes will require installing re-liquefaction unit on board FPSOs to convert gas into liquid for transportation by sea. But, then because of increased distance between gas source and receiving terminals the current medium size LNG ships will no longer remain economical to operate. Recognizing this business scenario shipowners are making huge investments in the acquisition of large LNG ships. As power need of large LNG ships is very different from the current small ones, a variety of propulsion derivatives such as UST, DFDE, 2-Stroke DRL and Combined cycle GT have been proposed by leading engine manufacturers. Since, propulsion system constitutes major element of the ship's capital and life cycle cost, which of these options is most suited for large LNG ships is currently a major concern of the shipping industry and must be thoroughly assessed. In this paper the authors investigate relative merits of these propulsion options against the benchmark performance criteria of BOG disposal, fuel consumption, gas emissions, plant availability and overall life cycle cost.

LNG development across Europe: Infrastructural and regulatory analysis

International Nuclear Information System (INIS)

Dorigoni, Susanna; Portatadino, Sergio

2008-01-01

In this paper, a cross-section infrastructural and regulatory analysis of the European LNG sector is presented. The LNG chain is maintained as being a good tool to enlarge the number of natural gas exporters to Europe, adding in this way to competition and to the achievement of the targets of the liberalisation process, which is a decrease in price for final customers and security of supply. The main reason for this is to be identified in the minor specificity of the regasification-plant-related investment compared with pipeline transportation. As a matter of fact, as the infrastructural analysis will show, the construction of new LNG receiving terminals is likely to bring about an increase in the number of importers fostering competition among them and shrinking their margins among the value chain. In this context, regulation is meant to play a key role in promoting investments without hindering competition. Nevertheless it is questionable whether LNG will be able to introduce competition beyond the European border (that is among producers) according to the forecasted supply and demand balance that is leading to a seller's market in the upstream sector. In this case, a huger part of the rent would go to the exporters leaving minor scope for competition down the European border. (author)

Total's LNG activities from Algeria to Yemen

International Nuclear Information System (INIS)

Vedrenne, J.P.

1997-01-01

In March 1995, further to an international tender, Total was awarded the leadership of the first LNG project in Yemen. On January 1997 Total announced the extension of the share-holding of the Yemen LNG Co. to include the companies with interests in the Marib area (Hunt-Exxon-Yukong). The Marib area will supply the gas to the future liquefaction plant. The ratification of these agreements confirms the role of Total as lead shareholder with 36% in the share-holding structure and guarantees gas supply from the Marib licence, operated by Hunt-Exxon. (author)

Industry brief letter; Oman LNG, Indo no hatsuden mukeni kyokyu

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-02-01

Oman LNG (OLNG), invested by Mitui Bussan, Mitsubishi Trading and Itochu Trading, concluded a supply contract of liquefied natural gas with a private power supply enterprise of India. Contract period is 20 years, and supplies 1.6 million ton LNG per year from the fourth quarter of 2001. This is the third contract case following to Korea Gas of Korea and Osaka Gas of Japan. OLNG will establish annual production 6.6 million system by the end of 1999. With this contract, almost all LNG production will be ensured to be sold by long term contracts. (translated by NEDO)

75 FR 53688 - Southern LNG Company, L.L.C.; Notice of Technical Conference

Science.gov (United States)

2010-09-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP10-829-000] Southern LNG Company, L.L.C.; Notice of Technical Conference August 25, 2010. Take notice that Commission Staff will... Street, NE., Washington, DC 20426. On June 7, 2010, Southern LNG Company, L.L.C. (Southern LNG) filed a...

Waiting for the Next Train? An Assessment of the Emerging Canadian LNG Industry

International Nuclear Information System (INIS)

Hureau, Geoffroy; Jordan, Louis

2015-03-01

In February 2015, Canada counted 22 LNG liquefaction plant projects - of which 17 are located in British Columbia - representing a total design capacity of 325 mmtpa. Canada has the potential to become a major LNG exporter but no project has received Final Investment Decision (FID) so far. Competition with US brown field projects with innovative business models have limited the commercial appeal of many Canadian projects relying on oil indexing. More recently, plummeting oil prices have put into question their profitability and lead to several postponements of FID reviews. This paper discusses the potential for Canada to export LNG, looking at the initial enthusiasm and wide support by public authorities and local communities but also at the economic challenges and commercial issues that are slowing the progress of these projects. In 2013, Canada owned 2,028 Bcm of proved natural gas reserves and in 2012, remaining marketable gas resources were estimated to exceed 30,000 Bcm, located mainly in the Western Canada Sedimentary Basin. In 2013, natural gas consumption grew due to higher demand from the tar sands industry and reached 90 Bcm, while marketed production rebounded slightly to 145 Bcm after 10 years of continuous decline. Net exports to the United States, the only export market for Canadian gas, kept decreasing to 55 Bcm. In the future, consumption is expected to grow at a slower rate than production and net exports to the United States to keep declining. As a consequence, LNG appears to be an ideal solution to monetize gas and to unlock these large resources. However, CEDIGAZ does not expect material LNG exports to start before 2021, but they could reach 34 mmtpa by 2035. Since the very beginning of the wave of LNG project proposals, Canadian federal and provincial authorities have appeared very supportive. At the provincial level, the government of British Columbia has multiplied initiatives to favor the emergence of a LNG industry, including by lowering

Radiation-induced heart injury

International Nuclear Information System (INIS)

Suzuki, Yoshihiko; Niibe, Hideo

1975-01-01

In order to identify radiation-induced heart injury and to differentiate it from heart disease, an attempt was made to clarify post-irradiation heart injury by investigating the histological changes which occur during the internal between the irradiation and the time of demonstrable histological changes. A study was made of 83 autopsies in which most of the primary neoplasms were breast cancers, lung cancers and mediastinal tumors. In 43 of these autopsies the heart had been irradiated. Sixty eight dd-strain mice were also used for microautoradiographic study. Histological changes in the heart were observed in 27 of the 43 cases receiving irradiation. The limit of the tolerance dose to the heart for indicating histological changes was 1220 ret in humans. The latent period without histological changes was 2.7 months after initiation of radiation therapy. Greater heart injury was observed after re-irradiation or after the combined therapy of radiation and chemotherapy especially mitomycin (MMC). The histological findings after treatment with MMC were similar to those of radiation-induced heart injury. Results of the study indicate that the damage is secondary to radiation-induced changes of the vascula connective tissue. (Evans, G.)

LNG (Liquefied Natural Gas): emerging control; GNL (Gas Natural Liquefeito): controle de emergencia

Energy Technology Data Exchange (ETDEWEB)

Berardinelli, Ricardo Porto; Correa, Kleber Macedo; Moura Filho, Nelson Barboza de; Matos, Jose Eduardo Nogueira de; Fernandez, Carlos Antonio [TRANSPETRO, Rio de Janeiro, RJ (Brazil). Gerencia de Seguranca, Meio Ambiente e Saude

2008-07-01

The operation to Liquefied Natural Gas (LNG) is innovative for the PETROBRAS System. PETROBRAS Transporte - TRANSPETRO will operate two LNG flexible terminals. In accordance with the health, safety and environmental policy - training, education and awareness action plans were formulated by TRANSPETRO to assure the operational safety for the activity. Part of this action plan includes the training of LNG spill control and fire suppression. The training was carried out in 20 hours and divided into two parts: theoretical and practice. In the practice part, 3.000 gallons of LNG were unloaded and the students could verify the behaviour of the LNG and the effectiveness of the resources available for the emergency control. The knowledge was introduced in the company to create specific procedures, local emergency plans and develop internal instructors. (author)

LNG peakshaving plant on the Maasvlakte, The Netherlands

Energy Technology Data Exchange (ETDEWEB)

Bijl, P

1975-06-01

N.V. Nederlandse Gasunie presents the situation which led to its decision to construct a LNG peakshaving plant on the Maasvlakte. The discussion includes peaks in gas transport, the effect of peakshaving upon transportation costs, the selection of the peakshaving method, and the LNG peakshaving plant ultimately chosen. The liquefaction cycle uses 2 loops, the first an open loop obtainin g refrigeration from expansion of natural gas through a turboexpander, the second a closed loop using nitrogen as refrigerant.

75 FR 13755 - Freeport LNG Development, L.P.; Application To Amend Blanket Authorization To Export Liquefied...

Science.gov (United States)

2010-03-23

... Delaware limited partnership with one general partner, Freeport LNG-GP, Inc., a Delaware corporation, which...). Freeport LNG's limited partners are: (1) Freeport LNG Investments, LLLP, a Delaware limited liability limited partnership, which owns a 45% limited partnership interest in Freeport LNG; (2) Cheniere FLNG, L.P...

Qualitative Risk Assessment for an LNG Refueling Station and Review of Relevant Safety Issues

Energy Technology Data Exchange (ETDEWEB)

Siu, N.; Herring, J.S.; Cadwallader, L.; Reece, W.; Byers, J.

1998-02-01

This report is a qualitative assessment of the public and worker risk involved with the operation of a liquefied natural gas (LNG) vehicle refueling facility. This study includes facility maintenance and operations, tank truck deliveries, and end-use vehicle fueling; it does not treat the risks of LNG vehicles on roadways. Accident initiating events are identified by using a Master Logic Diagram, a Failure Modes and Effects Analysis, and historical operating experiences. The event trees were drawn to depict possible sequences of mitigating events following the initiating events. The phenomenology of LNG and other vehicle fuels is discussed to characterize the hazard posed by LNG usage. Based on the risk modeling and analysis, recommendations are given to improve the safety of LNG refueling stations in the areas of procedures and training, station design, and the dissemination of ``best practice`` information throughout the LNG community.

Consensual decision-making model based on game theory for LNG processes

International Nuclear Information System (INIS)

Castillo, Luis; Dorao, Carlos A.

2012-01-01

Highlights: ► A Decision Making (DM) approach for LNG projects based on game theory is presented. ► DM framework was tested with two different cases, using analytical models and a simple LNG process. ► The problems were solved by using a Genetic Algorithm (GA) binary coding and Nash-GA. ► Integrated models from the design and optimization of the process could result in more realistic outcome. ► The major challenge in such a framework is related to the uncertainties in the market models. - Abstract: Decision-Making (DM) in LNG projects is a quite complex process due to the number of actors, approval phases, large investments and capital return in the long time. Furthermore, due to the very high investment of a LNG project, a detailed and efficient DM process is required in order to minimize risks. In this work a Decision-Making (DM) approach for LNG projects is presented. The approach is based on a consensus algorithm to address the consensus output over a common value using cost functions within a framework based on game theory. The DM framework was tested with two different cases. The first case was used for evaluating the performance of the framework with analytical models, while the second case corresponds to a simple LNG process. The problems were solved by using a Genetic Algorithm (GA) binary coding and Nash-GA. The results of the DM framework in the LNG project indicate that considering an integrated DM model and including the markets role from the design and optimization of the process more realistic outcome could be obtained. However, the major challenge in such a framework is related to the uncertainties in the market models.

Techno-economic Analysis of Acid Gas Removal and Liquefaction for Pressurized LNG

Science.gov (United States)

Lee, S. H.; Seo, Y. K.; Chang, D. J.

2018-05-01

This study estimated the life cycle cost (LCC) of an acid gas removal and a liquefaction processes for Pressurized LNG (PLNG) production and compared the results with the cost of normal LNG production. PLNG is pressurized LNG that is liquefied at a higher pressure and temperature than normal LNG. Due to the high temperature, the energy for liquefaction is reduced. The allowable CO2 concentration in PLNG is increased up to 3 mol% when the product pressure 25 bar. An amine process with 35 wt% of diethanolamine (DEA) aqueous solution and a nitrogen expansion cycle were selected for the acid gas removal and the liquefaction processes, respectively. Two types of CO2 concentration in the feed gas were investigated to analyze their impacts on the acid gas removal unit. When the CO2 concentration was 5 mol%, the acid gas removal unit was required for both LNG and PLNG production. However, the acid gas removal unit was not necessary in PLNG when the concentration was 0.5 mol% and the pressure was higher than 15 bar. The results showed that the LCC of PLNG was reduced by almost 35% relative to that of LNG when the PLNG pressure was higher than 15 bar.

LNG [liquefied natural gas]: Fueling energy demand in the Far East

International Nuclear Information System (INIS)

Brown, R.L.

1993-01-01

An overview is presented of the supply and demand outlook for liquefied natural gas (LNG) in the far east, and the basic elements of an LNG supply project in Japan. Power generation is the primary market for LNG in the far east, due to a preference for energy supply diversity, large undeveloped gas resources, drastic improvements in power generation technology, and environmental advantages of natural gas. India and mainland China represent huge potential markets, and projects are under discussion to bring gas by pipeline from Iran or Qatar to both Pakistan or India. The economics of LNG plant development in Japan, including large ($4 billion for field and plant development) capital costs, long-term contracts, government involvement, and gas prices are discussed. Falling yen/dollar exchange rates have substantially bettered the Japanese economy in terms of gas prices. 11 figs., 2 tabs

Modeling the release, spreading, and burning of LNG, LPG, and gasoline on water

International Nuclear Information System (INIS)

Johnson, David W.; Cornwell, John B.

2007-01-01

Current interest in the shipment of liquefied natural gas (LNG) has renewed the debate about the safety of shipping large volumes of flammable fuels. The size of a spreading pool following a release of LNG from an LNG tank ship has been the subject of numerous papers and studies dating back to the mid-1970s. Several papers have presented idealized views of how the LNG would be released and spread across a quiescent water surface. There is a considerable amount of publicly available material describing these idealized releases, but little discussion of how other flammable fuels would behave if released from similar sized ships. The purpose of this paper is to determine whether the models currently available from the United States Federal Energy Regulatory Commission (FERC) can be used to simulate the release, spreading, vaporization, and pool fire impacts for materials other than LNG, and if so, identify which material-specific parameters are required. The review of the basic equations and principles in FERC's LNG release, spreading, and burning models did not reveal a critical fault that would prevent their use in evaluating the consequences of other flammable fluid releases. With the correct physical data, the models can be used with the same level of confidence for materials such as LPG and gasoline as they are for LNG

The Evolving Role of LNG in the Gas Market

Energy Technology Data Exchange (ETDEWEB)

De Jong, D.; Van der Linde, C.; Smeenk, T.

2010-09-15

The global energy scene is changing rapidly. Producing countries are tightening their grip on the development of their resources, emerging (and other) economies are taking a direct political interest in securing supplies, politics and business are increasingly integrated in international energy deals, and energy is on the political agenda of every government. Compounding this, prices of energy skyrocketed over the four years leading up to August 2008. As a result more gas resources became economical to develop, creating more supply potential than before. However, the severe crisis in international financial markets and national banking systems is now changing this outlook. Prices have come down, and this, combined with the current decline in economic activity, is likely to affect the timing of investment decisions on new pipeline and liquefied natural gas (LNG) projects. The impact on national economies on energy demand, and on the relative position of gas in the energy market could be considerable. At the same time, some consuming countries are also reviewing the environmental effect of their energy policies and the security of their energy supply. Any change in these policies could affect the place of gas in the energy mix. These developments are still unfolding; it is difficult to say at this stage in what ways and to what extent the position of natural gas will change. Nevertheless, some expect further globalization of the gas business, with different market structures, more fragmented value chains, more flexibility in supplies to markets, and shorter term contracts. In this respect, LNG is regarded as the major potential game changer. Indeed the LNG business model has been changing over recent years into one of greater flexibility, promising producers higher rewards, albeit in return for higher risks. More recently the perspective of high rewards in a market hungry for supplies has changed radically, at least for the next few years. A global crisis, lower oil

The Evolving Role of LNG in the Gas Market

International Nuclear Information System (INIS)

De Jong, D.; Van der Linde, C.; Smeenk, T.

2010-01-01

The global energy scene is changing rapidly. Producing countries are tightening their grip on the development of their resources, emerging (and other) economies are taking a direct political interest in securing supplies, politics and business are increasingly integrated in international energy deals, and energy is on the political agenda of every government. Compounding this, prices of energy skyrocketed over the four years leading up to August 2008. As a result more gas resources became economical to develop, creating more supply potential than before. However, the severe crisis in international financial markets and national banking systems is now changing this outlook. Prices have come down, and this, combined with the current decline in economic activity, is likely to affect the timing of investment decisions on new pipeline and liquefied natural gas (LNG) projects. The impact on national economies on energy demand, and on the relative position of gas in the energy market could be considerable. At the same time, some consuming countries are also reviewing the environmental effect of their energy policies and the security of their energy supply. Any change in these policies could affect the place of gas in the energy mix. These developments are still unfolding; it is difficult to say at this stage in what ways and to what extent the position of natural gas will change. Nevertheless, some expect further globalization of the gas business, with different market structures, more fragmented value chains, more flexibility in supplies to markets, and shorter term contracts. In this respect, LNG is regarded as the major potential game changer. Indeed the LNG business model has been changing over recent years into one of greater flexibility, promising producers higher rewards, albeit in return for higher risks. More recently the perspective of high rewards in a market hungry for supplies has changed radically, at least for the next few years. A global crisis, lower oil

Clean sailing. LNG terminals. Maritime infrastructure for liquefied natural gas; Sauber auf See. LNG-Terminals. Maritime Infrastruktur fuer fluessiges Erdgas

Energy Technology Data Exchange (ETDEWEB)

Anon.

2013-09-01

Ports act as essential hubs in the global economy. But the rise in maritime traffic is taking a toll on the quality of air in ports and out at sea. From 2015 onwards, threshold governing harmful emissions are being tightened in a bid to clear the air. All of which is driving interest in more environmentally sound fuels. Liquefied natural gas (LNG) is the perfect fit, more than complying with the upcoming regulations. To enable its widespread adoption, Linde is working full steam ahead to create a network of LNG terminals in Europe. (orig.)

Application tests of a new-type LNG rapid gasification unit

Directory of Open Access Journals (Sweden)

Ping Yan

2017-01-01

Full Text Available Liquefied natural gas (LNG is stored under low temperature and high pressure. It has to be gasified before it is used. Therefore, LNG gasification unit is essential and it is vital to the high-efficiency utilization of LNG. In this paper, a new-type LNG rapid gasification unit was developed. Adopted in this unit are some innovative technologies authorized with the national patent of invention, such as the umbrella-shape gas flow circle unit, the flue gas circulation system and the water feeding system, which help to guarantee its operation safety and increase its operation efficiency. After it was justified in lab test, the unit for industrial application was designed and manufactured and then tested to verify its design rationality. The results show that the new-type LNG rapid gasification unit meets the design requirements in the aspect of efficiency, exhaust gas loss, radiation loss and fuel gas consumption rate; at a load of 1800–2200 m3/h, its efficiency is over 95%; at a load of 1976.0 m3/h which is close to the design value of 2000 m3/h, its efficiency is 96.34% or even up to 2800 m3/h. This new-type LNG rapid gasification unit is adaptable to a large range of loads and can adapt to the rapid increase of external load. Its fuel gas consumption rate is only 1.5%, which is in the range of energy conservation. It presents the advantages of high heating efficiency, rapid startup, high gasification rate, compact structure, small land occupation and invulnerability to the environment, therefore, it is applicable to the middle and small independent regions which cannot be connected to the natural gas supply pipeline networks due to various reasons.

Numerical investigation of supercritical LNG convective heat transfer in a horizontal serpentine tube

Science.gov (United States)

Han, Chang-Liang; Ren, Jing-Jie; Dong, Wen-Ping; Bi, Ming-Shu

2016-09-01

The submerged combustion vaporizer (SCV) is indispensable general equipment for liquefied natural gas (LNG) receiving terminals. In this paper, numerical simulation was conducted to get insight into the flow and heat transfer characteristics of supercritical LNG on the tube-side of SCV. The SST model with enhanced wall treatment method was utilized to handle the coupled wall-to-LNG heat transfer. The thermal-physical properties of LNG under supercritical pressure were used for this study. After the validation of model and method, the effects of mass flux, outer wall temperature and inlet pressure on the heat transfer behaviors were discussed in detail. Then the non-uniformity heat transfer mechanism of supercritical LNG and effect of natural convection due to buoyancy change in the tube was discussed based on the numerical results. Moreover, different flow and heat transfer characteristics inside the bend tube sections were also analyzed. The obtained numerical results showed that the local surface heat transfer coefficient attained its peak value when the bulk LNG temperature approached the so-called pseudo-critical temperature. Higher mass flux could eliminate the heat transfer deteriorations due to the increase of turbulent diffusion. An increase of outer wall temperature had a significant influence on diminishing heat transfer ability of LNG. The maximum surface heat transfer coefficient strongly depended on inlet pressure. Bend tube sections could enhance the heat transfer due to secondary flow phenomenon. Furthermore, based on the current simulation results, a new dimensionless, semi-theoretical empirical correlation was developed for supercritical LNG convective heat transfer in a horizontal serpentine tube. The paper provided the mechanism of heat transfer for the design of high-efficiency SCV.

Structural response of cargo containment systems in LNG carriers under ice loads

International Nuclear Information System (INIS)

Wang, B.; Yu, H.; Basu, R.; Lee, H.; Kwon, J.C.; Jeon, B.Y.; Kim, J.H.; Daley, C.; Kendrick, A.

2008-01-01

Gas exploration has been extended into the Arctic region such as in the Russian Arctic area, because of the increasing demand for energy resources. As a result, shipping in ice-covered seas is also increasing. Many technical issues are involved in ensuring the safety of liquefied natural gas (LNG) ships during the transportation. This paper discussed an investigation of ship-ice interaction scenarios for possible operation routes in Arctic areas. Six scenarios were selected to study the structural response of cargo containment systems (CCS) in both membrane and spherical types of LNG ships. For selected ship-ice interaction scenarios, ice loads and loading areas in the hull structure were determined based on the energy theory. The configurations of LNG carriers were discussed and illustrated. The paper also outlined the assessment criteria and structure analysis procedures. It was concluded that the strength of the CCS of membrane-type LNG carrier and the strength of the skirt structure of spherical-type LNG carrier were strong enough under the design ice loads. 13 refs., 9 tabs., 18 figs

LNG containment release: Comparison of NFPA-59A and 49-CFR-193

International Nuclear Information System (INIS)

West, H.H.; Pfenning, D.B.

1994-01-01

Due to the potential wide area impact of an unplanned LNG (Liquefied Natural Gas) release, the National Fire Protection Association (NFPA) and later the US Department of Transportation issued standards and regulations which included specific methodologies for analyzing the consequence of an accidental LNG release. The concept of a ''design spill'' was defined in order to evaluate the consequences of an accidental LNG release, with particular attention to the influence of safety protective measures. In addition to specifying the magnitude of the unplanned release, the design spill also specified some of the parameters for estimation of the downwind LNG vapor dispersion and the extent of the radiant heat from an LNG pool fire. Since the NFPA-59A and 49-CFR-193 standards were the first in-depth regulation to address consequence analysis estimation for petroleum components, it is particularly important to consider their details in light of the recently proposed EPA 40-CFR-68 regulations [Risk Management for Chemical Accidental Release Prevention] which specifically address consequence analysis as a part of process safety management

Alternative natural gas contract and pricing structures and incentives for the LNG industry

International Nuclear Information System (INIS)

Attanasi, E.D.

1991-01-01

Gas conversion to liquefied gas (LNG) and transport by LNG tankers is one option for meeting expanding gas consumption and for gas traded internationally. This paper examines the impact of the traditional gas contract provisions of indefinite pricing, market out price ceilings, and take-or-pay requirements on the profitability of LNG projects in the context of markets characterized by price and quantity uncertainty. Simulation of experiments are used to examine and calibrate the effects of those provisions. The results provide guidance to operators, host countries and purchasers in structuring such contracts. The paper also assesses prospects of future expansion of world LNG capacity. (author). 11 refs, 3 figs, 4 tabs

Interim qualitative risk assessment for an LNG refueling station and review of relevant safety issues

Energy Technology Data Exchange (ETDEWEB)

Siu, N.; Herring, S.; Cadwallader, L.; Reece, W.; Byers, J.

1997-07-01

This report is a qualitative assessment of the public and worker risk involved with the operation of a liquefied natural (LNG) vehicle refueling facility. This study includes facility maintenance and operations, tanker truck delivers and end-use vehicle fueling; it does not treat the risks of LNG vehicles on roadways. Accident initiating events are identified by using a Master Logic Diagram, a Failure Modes and Effects analysis and historical operating experiences. The event trees were drawn to depict possible sequences of mitigating events following the initiating events. The phenomenology of LNG and other vehicle fuels is discussed to characterize the hazard posed by LNG usage. Based on the risk modeling and analysis, recommendations are given to improve the safety of LNG refueling stations in the areas of procedures and training, station design, and the dissemination of best practice information throughout the LNG community.

Performance of cryogenic thermoelectric generators in LNG cold energy utilization

International Nuclear Information System (INIS)

Sun Wei; Hu Peng; Chen Zeshao; Jia Lei

2005-01-01

The cold energy of liquefied natural gas (LNG) is generally wasted when the LNG is extracted for utilization. This paper proposes cryogenic thermoelectric generators to recover this cold energy. The theoretical performance of the generator has been analyzed. An analytical method and numerical method of calculation of the optimum parameters of the generator have been demonstrated

Training simulator for operations at LNG terminals

International Nuclear Information System (INIS)

Tsuta, T.; Yamamoto, K.; Tetsuka, S.; Koyama, K.

1997-01-01

The Tokyo Gas LNG terminals are among the major energy centers of the Tokyo area, supplying 8 million customers with city gas, and also supplying fuel for thermal power generation at the neighboring thermal power plant operated by the Tokyo Electric Power Company. For this reason, in the event of an emergency at the terminal operators have to be able to respond quickly and accurately to restore operations and prevent secondary damage. Modern LNG terminals are highly reliable and are equipped with backup systems, and occurrences of major trouble are now almost nil. Operators therefore have to be trained to respond to emergencies using simulators, in order to heighten their emergency response capabilities. Tokyo Gas Co., Ltd. has long been aware of the need for simulators and has used them in training, but a new large-scale, real-time simulator has now developed in response to new training needs, applying previously accumulated expertise to create a model of an entire LNG terminal incorporating new features. The development of this new simulator has made possible training for emergencies affecting an entire terminal, and this has been very effective in raising the standards of operators. (au)

LNG terminal location still a tossup

Index Scriptorium Estoniae

2011-01-01

Lätti rajatava LNG terminali asukoht pole veel teada. 16. märtsil kohtus Poola president Bronislaw Komorowki Läti riigipea Valdis Zatlersiga ja kiitis selle projekti heaks. Venemaast energiasõltumatuse olulisusest

Meeting the energy needs of the northeast : the role for LNG

International Nuclear Information System (INIS)

Van der Put, J.

2004-01-01

This presentation outlined the role of liquefied natural gas (LNG) in meeting the energy requirements of the northeastern regions of the United States and Canada, as seen from the perspective of TransCanada. The need for LNG to meet projected growth in natural gas demand was presented in the context of a business model for TransCanada's entry into the LNG market. A plan for the successful siting and construction of import terminals in various strategic locations in the Northeast was presented. Issues surrounding supply and demand for LNG in North America, with specific reference to the Northeastern regions, were examined. Tables of existing import terminals were presented. Forecasts of demand growth were provided as well as details of natural gas transmission and power assets. A detailed description of the Fairwinds Project included existing and proposed pipelines, site descriptions and an outline of a stakeholder engagement campaign with examples of support and opposition as well as community impacts of the project. A behavioral guideline suggested that specific commitments should be made rather than generalized promises. A list of lessons learned from the Fairwinds project was also included. The potential to land LNG in Quebec was examined, with details of the rationale behind the proposed projects, shipping distance advantages and ice management. 16 figs

The gas century: worldwide LNG developments may deal death blow to Alaskan pipeline dream

International Nuclear Information System (INIS)

Lorenz, A.

2004-01-01

The growing interest in liquefied natural gas (LNG), which casts doubt on the viability of the Alaska gas pipeline, and the potential impacts on Canadian gas exports to the United States are discussed. There is currently a proposal before Congress for an Alaskan LNG project, and consensus appears to be building among American energy experts and law-makers that building a multitude of LNG facilities would be more flexible and cheaper than building the proposed Alaska pipeline. As further proof of the growing popularity of LNG, U.S. industry lobbyists are said to be rapidly gaining congressional support for the idea of building eight to ten billion cubic feet per day of LNG capacity along the U. S. coast. Either development, -- LNG facilities or the Alaska pipeline -- have the potential to seriously impact Canadian natural gas exports. If the Alaska pipeline is built, the addition of five billion cubic feet per day of new gas on the market would cause gas prices to fall; if the U.S. decides to subsidize its gas industry, Canadian gas would be put at a serious disadvantage. Conversely, if the Alaskan LNG proposal were to succeed, the potential demise of the Alaska pipeline would mean the loss of about 12,000 jobs that would be created during the Canadian construction phase of the pipeline, as well as the loss of tariffs. Industry experts predict that by 2005 LNG terminals will dot the periphery of the U. S. coast line; to prepare for these eventualities, Canadian companies, such as Irving Oil, TransCanada Pipelines and EnCana are taking note, and are scrambling not to be left out of the game. As proof of the seriousness of their concern, Irving Oil is adding a Can$500 million LNG facility to its Canaport terminal on the Scotian shelf; TCPL is working to supply an LNG terminal offshore Massachusetts, and EnCana is refurbishing a Louisiana salt cavern to prepare for storage of gas delivered to the Gulf Coast

File list: DNS.Lng.20.AllAg.Lung_adenocarcinoma [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available DNS.Lng.20.AllAg.Lung_adenocarcinoma mm9 DNase-seq Lung Lung adenocarcinoma http://...dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.Lng.20.AllAg.Lung_adenocarcinoma.bed ...

Trading in LNG and natural gas

International Nuclear Information System (INIS)

1992-01-01

We have examined the market for natural gas from a number of viewpoints, starting with the role of natural gas in the global energy market where its 20% share of primary energy demand has been captured in the space of almost as many years. In discussion regional energy markets we cover the disparities between supply and demand which give rise to trade by pipeline, and by sea in the form of liquefied natural gas (LNG). Both have in fact increased steadily in recent years, yet even in 1991, only 12-15% of total gas production was traded across international boundaries, whereas for oil it was closer to 40%. For the moment pipeline trade remains heavily concentrated in Europe and North America, and it is in the LNG sector where the spread of projects, both existing and planned, is more global in nature. We examine the development of LNG trades and the implications for shipping. Finally, we look at transportation costs, which are likely to be an important component in the viability of many of the natural gas export schemes now under review. There is good reason to be ''bullish'' about parts of the natural gas industry but this Report suggests that there are areas of concern which could impinge on the development of the market in the 1990s. (author)

European gas markets and Russian LNG. Prospects for the development of European gas markets and model simulations of possible new LNG supplies from year 2000

Energy Technology Data Exchange (ETDEWEB)

Eldegard, Tom [Foundation for Research in Economics and Business Administration, Bergen (Norway)

1996-07-01

The study aims at clarifying the framework for possible LNG exports from Northern Russia and focuses on the European natural gas markets. The first stage provides general background information on the market structure and related topics. In the second stage this information is used to develop a formal market model and subject it to simulations with various assumptions of the future gas supply. The model is described and results from simulations are given. In the first stage facts from the history of the European natural gas market are outlined. Underlying conditions for the development of natural gas markets in Europe are addressed. The EU has been promoting trade liberalisation in the energy sector but most counties resist freer gas trade across the boarders. New infrastructure development for natural gas are either underway or planned. Some important projects are mentioned. Gas in a global perspective is discussed. The cost structure of the LNG chain is mentioned and an overview of existing LNG export capacities world-wide and major reception terminals in Europe and the USA is given. The second stage employs a scenario analysis to evaluate the economic effects of hypothetical LNG deliveries from Northern Russia. The model is developed for the analysis of West European natural gas markets and designed to allow users to create a structural system of interconnected producers and market regions. Basic assumptions for the evolution of natural gas markets till 2005 is developed and base case scenarios calculated for the years 2000 and 2005 and used as a point of reference for the alternative scenarios considered. According to the analysis the introduction of a new LNG supplier in the European gas market will inflict a substantial loss upon all the existing producers. The primary keys to this result are the assumptions made for gas demand and supply capacity. The LNG alternative will hardly be approved for purely economic reasons as long as the Russians maintain

European gas markets and Russian LNG. Prospects for the development of European gas markets and model simulations of possible new LNG supplies from year 2000

International Nuclear Information System (INIS)

Eldegard, Tom

1996-01-01

The study aims at clarifying the framework for possible LNG exports from Northern Russia and focuses on the European natural gas markets. The first stage provides general background information on the market structure and related topics. In the second stage this information is used to develop a formal market model and subject it to simulations with various assumptions of the future gas supply. The model is described and results from simulations are given. In the first stage facts from the history of the European natural gas market are outlined. Underlying conditions for the development of natural gas markets in Europe are addressed. The EU has been promoting trade liberalisation in the energy sector but most counties resist freer gas trade across the boarders. New infrastructure development for natural gas are either underway or planned. Some important projects are mentioned. Gas in a global perspective is discussed. The cost structure of the LNG chain is mentioned and an overview of existing LNG export capacities world-wide and major reception terminals in Europe and the USA is given. The second stage employs a scenario analysis to evaluate the economic effects of hypothetical LNG deliveries from Northern Russia. The model is developed for the analysis of West European natural gas markets and designed to allow users to create a structural system of interconnected producers and market regions. Basic assumptions for the evolution of natural gas markets till 2005 is developed and base case scenarios calculated for the years 2000 and 2005 and used as a point of reference for the alternative scenarios considered. According to the analysis the introduction of a new LNG supplier in the European gas market will inflict a substantial loss upon all the existing producers. The primary keys to this result are the assumptions made for gas demand and supply capacity. The LNG alternative will hardly be approved for purely economic reasons as long as the Russians maintain

File list: Pol.Lng.10.AllAg.Lung_adenocarcinoma [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Lng.10.AllAg.Lung_adenocarcinoma mm9 RNA polymerase Lung Lung adenocarcinoma ht...tp://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Lng.10.AllAg.Lung_adenocarcinoma.bed ...

LNG. Practice and policy. Meeting report NeVER, November 20, 2006

International Nuclear Information System (INIS)

Holzhauer, R.W.

2007-01-01

Report is given of a meeting of the Netherlands Association for Energy Legislation (NeVER), which was held November 16, 2006, in Amsterdam, on the subject of LNG. More in particular third party access to LNG-terminals and related exemption regulations in Europe and the Netherlands [nl

The Triaging and Treatment of Cold-Induced Injuries.

Science.gov (United States)

Sachs, Christoph; Lehnhardt, Marcus; Daigeler, Adrien; Goertz, Ole

2015-10-30

In Central Europe, cold-induced injuries are much less common than burns. In a burn center in western Germany, the mean ratio of these two types of injury over the past 10 years was 1 to 35. Because cold-induced injuries are so rare, physicians often do not know how to deal with them. This article is based on a review of publications (up to December 2014) retrieved by a selective search in PubMed using the terms "freezing," "frostbite injury," "non-freezing cold injury," and "frostbite review," as well as on the authors' clinical experience. Freezing and cold-induced trauma are part of the treatment spectrum in burn centers. The treatment of cold-induced injuries is not standardized and is based largely on case reports and observations of use. distinction is drawn between non-freezing injuries, in which there is a slow temperature drop in tissue without freezing, and freezing injuries in which ice crystals form in tissue. In all cases of cold-induced injury, the patient should be slowly warmed to 22°-27°C to prevent reperfusion injury. Freezing injuries are treated with warming of the body's core temperature and with the bathing of the affected body parts in warm water with added antiseptic agents. Any large or open vesicles that are already apparent should be debrided. To inhibit prostaglandin-mediated thrombosis, ibuprofen is given (12 mg/kg body weight b.i.d.). The treatment of cold-induced injuries is based on their type, severity, and timing. The recommendations above are grade C recommendations. The current approach to reperfusion has yielded promising initial results and should be further investigated in prospective studies.

LNG, Competition and Security of Supply: the Role of Shipping

International Nuclear Information System (INIS)

Dorigoni, S.; Mazzei, L.; Pontoni, F.; Sileo, A.

2009-01-01

In the last few years, one of the main concerns of European Union in the energetic field has been that of facilitating the safeguard of raw materials' security of supply, especially that of natural gas. Import through LNG chain, that is, through the employment of LNG tankers for gas transportation, has been identified by the European Council as one of the instruments to achieve these goals. In fact, import via LNG does not require, for the importer, such investments as to determine an indissoluble physical tie between producer and buyer, as happens for transport via pipeline (Chernyavska et al., 2002). In other words, investments in pipelines are very specific. Moreover, as they are made in order to support specific transactions, contracts usually take the form of long-term agreements with minimum off take requirements (take or pay clauses): such contracts definitely contribute to the cartelization of the market, hindering competition. Unlike investments in pipelines, those in the LNG chain present a much lower degree of specificity: in fact, even though the construction of a re gasification plant is generally tied to the stipulation of a long-term agreement (with take or pay clause), LNG chain costs have significantly decreased over time (until a few years ago) and, moreover, it is getting increasingly common that part of plant capacity is made available for spot transactions. What's more, once the contract is expired and the investment is sunk, the importer may satisfy his gas supply needs on the basis of his relative gains. As far as LNG import contractual practices are concerned, significant changes have started to take places in the last few years, both in terms of agreements' length average duration has significantly decreased and in terms of price indexation in the most developed markets LNG price is tied to gas spot price (IEA, 2006). One of the many possible advantages of transport via LNG is that liquefied gas enables European importers to widen their gas

File list: ALL.Lng.05.AllAg.Lung_adenocarcinoma [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.Lng.05.AllAg.Lung_adenocarcinoma mm9 All antigens Lung Lung adenocarcinoma SRX2...RX213848 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Lng.05.AllAg.Lung_adenocarcinoma.bed ...

Concept for a LNG Gas Handling System for a Dual Fuel Engine

Directory of Open Access Journals (Sweden)

Michael Rachow

2017-09-01

Full Text Available Nowadays, ships are using LNG as main engine fuel because based on the facts that LNG has no sulphur content, and its combustion process, LNG produces low NOx content compared to heavy fuel oil and marine diesel oil. LNG is not only produces low gas emission, but may have economic advantages. In the engine laboratory of maritime studies department in Warnemunde, Germany, there is a diesel engine type MAN 6L23/30 A, where the mode operation of these engine would be changed to dual fuel engine mode operation. Therefore, in this thesis, the use dual fuel engine will be compared where it will utilize natural gas and marine diesel oil and select the required components for fuel gas supply system. By conducting the process calculation, engine MAN 6L23/30 A requires the capacity natural gas of 12.908  for 5 days at full load. A concept for LNG supply system would be arranged from storage tank until engine manifold. Germanischer Lloyd and Project Guide of dual fuel engine will be used as a guidelines to develop an optimal design and arrangement which comply with the regulation.

Development and industrial tests of the first LNG hydraulic turbine system in China

Directory of Open Access Journals (Sweden)

Jie Chen

2016-10-01

Full Text Available The cryogenic hydraulic turbine can be used to replace the conventional J–T valve for LNG or mixed refrigerant throttling and depressurization in a natural gas liquefaction plant. This advanced technology is not only to enhance the efficiency of the liquefaction plant, but to usher a new trend in the development of global liquefaction technologies. China has over 136 liquefaction plants, but the cryogenic hydraulic turbines have not been deployed in industrial utilization. In addition, these turbines cannot be manufactured domestically. In this circumstance, through working on the key technologies for LNG hydraulic turbine process & control system development, hydraulic model optimization design, structure design and manufacturing, the first domestic cryogenic hydraulic turbine with a flow rate of 40 m3/h was developed to recover the pressure energy from the LNG of cold box. The turbine was installed in the CNOOC Zhuhai Natural Gas Liquefaction Plant for industrial tests under multiple working conditions, including start-stop, variable flow rates and variable rotation speeds. Test results show that the domestic LNG cryogenic hydraulic turbine has satisfactory mechanical and operational performances at low temperatures as specified in design. In addition, the process & control system and frequency-conversion power-generation system of the turbine system are designed properly to automatically and smoothly replace the existing LNG J–T valve. As a result, the domestic LNG cryogenic hydraulic turbine system can improve LNG production by an average of 2% and generate power of 8.3 kW.

LNG vapor dispersion prediction with the DEGADIS dense-gas dispersion model. Topical report, April 1988-July 1990. Documentation

International Nuclear Information System (INIS)

Havens, J.; Spicer, T.

1990-09-01

The topical report is one of a series on the development of methods for LNG vapor dispersion prediction for regulatory application. The results indicate that the DEGADIS model is superior both phenomenologically and in performance to the Gaussian line source model promulgated in 49 CFR 193 for LNG vapor dispersion simulation. Availability of the DEGADIS model for VAX and IBM-PC formats provides for wider use of the model and greater potential for industry and regulatory acceptance. The acceptance is seen as an important interim objective while research continues on vapor dispersion estimation methods which provide for effects of vapor detention systems, turbulence induced by plant structure, and plant/area topographical features

Study of Volatility of New Ship Building Prices in LNG Shipping

Directory of Open Access Journals (Sweden)

T. Bangar Raju

2016-12-01

Full Text Available The natural gas market has been expanding in size and has attracted particular attention across the global energy market. Although most natural gas transportation is carried out through pipelines, almost one third of it is done with the help of merchant vessels, capable of carrying liquefied natural gas. These LNG carriers have a special design and thus can be treated as a separate class of global fleet. New vessels are huge capital investments by vessel owning companies and just like other vessel classes; the new shipbuilding prices for the LNG segment continue to be a key aspect in the decision making of business players. Additionally these prices can be volatile as new ship building prices fluctuate with time. This paper attempts to analyse the volatility of new ship building prices of LNG carriers. For the study, the average ship building prices for all the LNG carriers having volume carrying capacity is between 160,000 – 173,000 cbm to be delivered between 2016 – 2019 were taken into account. For the analysis, GARCH and EGARCH methods were applied on the data set. The analysis concluded that there is a great deal of volatility in the new ship building prices of LNG vessels. It was also identified that negative shocks were more persistent the positive shocks.

Preconditions for the development of land-based infrastructure for liquefied natural gas (LNG / LBG); Foerutsaettningar foer utbyggnad av landbaserad infrastruktur foer flytande gas (LNG/LBG)

Energy Technology Data Exchange (ETDEWEB)

Stenkvist, Maria; Paradis, Hanna; Haraldsson, Kristina; Beijer, Ronja; Stensson, Peter (AaF Industry AB(Sweden))

2011-06-15

The conversion potential to replace oil in the energy intensive industries and diesel in heavy transport is estimated in the study to 6.8 TWh and 10 TWh per year, respectively. Several alternative fuels compete for this conversion potential. What fuels will take market share depends on several factors such as price, availability of fuel, availability of process technology and vehicles, technology development and possible future technological advances. For liquid methane to compete a new infrastructure is required that in a cost effective manner makes it possible to distribute the liquid methane to the regions where the need is the greatest. With today's distribution system, including truck delivery from import terminals in Nynaeshamn and Fredrikstad, virtually the entire southern Sweden is within reach of LNG deliveries. The study points out three nodes, Gaevle, Sundsvall and Luleaa, which is suitable for distribution of liquid methane to the central and northern Sweden. The three hubs are suitable for freight transfer to trucks as well as rail and shipping. A strategic nationwide network of refueling stations is also proposed, with a total of 18 new stations, in addition to the filling stations in southern and central Sweden that are already planned or in operation. Both the availability and use of liquid methane in Sweden today is limited. Liquid natural gas, LNG (liquefied natural gas), is primarily used as a backup to biogas plants, in a few industries and as supply for a few filling stations for compressed gas. The availability of LNG and also liquid biogas (LBG liquefied biogas), will increase in coming years. In 2011, two new LNG import terminals are put into operation in Nynaeshamn and Fredrikstad in Norway and two additional import terminals are planned in Gothenburg and Lysekil. Furthermore, two production plants for liquid biogas production have started, and four additional plants are planned, which together will produce around 0.5 TWh LBG annually

Demand management of city gas per season and study of estimating proper size of LNG storage facilities

Energy Technology Data Exchange (ETDEWEB)

Jung, Y.H.; Kim, S.D. [Korea Energy Economics Institute, Euiwang (Korea, Republic of)

1997-09-01

LNG storage facilities are indispensable to satisfy demand throughout the year by saturating the time difference of supply and demand that appears due to seasonal factors. The necessity of storage facilities is more important in a country like Korea where LNG is not produced at all and imports are relied upon. The problem of deciding how much storage facilities to keep and in what pattern to import LNG is a question to solve in order to minimize the costs related to the construction of LNG storage facilities while not causing any problem in the supply and demand of LNG. This study analyzes how the import of LNG and the consumption pattern of LNG for power generation affect the decision on the size of storage facilities. How the shipping control, and how LNG demand for power generation affect the decision of requirement of storage facilities, and why the possibility of shipping control should be investigated in the aspect of costs is investigated. As a result of this study, I presented necessary basic data for drafting a policy by assessing the minimum requirements of storage facilities needed for balancing the supply and demand with the various shipping control and LNG consumption patterns through simulation up to the year 2010. 10 refs., 33 figs., 66 tabs.

LNG shipping at 50, SIGTTO at 35 and GIIGNL at 43. A commemorative SIGTTO/GIIGNL publication 2014

International Nuclear Information System (INIS)

Corkhill, Mike; Harris, Syd; Clifton, Andrew; Wayne, Bill; Robin, Jean-Yves

2014-01-01

Jointly sponsored by SIGTTO and GIIGNL, LNG Shipping at 50 is a celebration of the first half century of commercial LNG carrier and terminal operations. The publication also marks the 35. and 43. anniversaries of the Society of International Gas Tanker and Terminal Operators (SIGTTO) and the International Group of LNG Importers (GIIGNL), respectively. The two organisations and their memberships have done a sterling job of developing guidance on safe operations; promulgating industry best practice; and providing forums for the airing of concerns and discussion of topical issues. The exemplary safety record built up by the LNG shipping and terminal industry over the past five decades owes much to the central roles played by SIGTTO and GIIGNL. The LNG industry has an exceptional story to tell and LNG Shipping at 50 contributes to the telling of that story. The publication starts with a review of the early days to show how the industry developed the innovative solutions needed to ensure the safe transport of LNG by sea. The articles in this section then describe how these solutions were then continuously improved upon as more countries turned to seaborne natural gas imports to meet their energy needs. Pioneering people, ships, shipyards, containment systems, class societies and equipment suppliers are reviewed to highlight the key role they played in facilitating the safe and smooth operation of the LNG supply chain, including at the critical ship/shore interface. Safety is the No 1 priority in the LNG industry and the safety regime section of the magazine examines the cornerstones that underpin an unparalleled safety record. Quite aside from the IGC Code and the work of SIGTTO and GIIGNL, there are the contributions of class, training establishments, vetting programmes and escort tug services. LNG Shipping at 50's survey of progress to date is followed by a look at the many innovations introduced by the industry in more recent years, not least floating LNG

Pac-Rim LNG project : final project report specifications

International Nuclear Information System (INIS)

1996-01-01

PAC-RIM LNG Inc. has submitted a proposal to the British Columbia Environmental Assessment Office, to develop a liquefied natural gas project which would purchase pipeline quality natural gas from sources in northeast British Columbia and Alberta and transport it via a dedicated pipeline system to a LNG processing plant on tidewater on the Pacific coast. The project would include storage and processing facilities and a marine loading terminal. This document sets out the final project report specifications prepared by the Project Committee on the basis of input received from the public, First Nations and federal, provincial and local governments

LNG Regasification Terminals: The Role of Geography and Meteorology on Technology Choices

Directory of Open Access Journals (Sweden)

Randeep Agarwal

2017-12-01

Full Text Available Liquefied natural gas (LNG projects are regulated by host countries, but policy and regulation should depend on geography and meteorology. Without considering the role of geography and meteorology, sub-optimal design choices can result, leading to energy conversion efficiency and capital investment decisions that are less than ideal. A key step in LNG is regasification, which transforms LNG back from liquid to the gaseous state and requires substantial heat input. This study investigated different LNG regasification technologies used around the world and benchmarked location and meteorology-related factors, such as seawater temperatures, ambient air temperatures, wind speeds and relative humidity. Seawater vaporizers are used for more than 95% of locations subject to water quality. Ambient air conditions are relatively better for South America, India, Spain and other Asian countries (Singapore, Taiwan, Indonesia, and Thailand and provide a much cleaner regasification technology option for natural and forced draft systems and air-based intermediate fluid vaporizers. On a global basis, cold energy utilization currently represents <1% of the total potential, but this approach could deliver nearly 12 Gigawatt (GW per annum. Overall, climate change is expected to have a positive financial impact on the LNG regasification industry, but the improvement could be unevenly distributed.

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Lifescience Database Archive (English)

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Exergy recovery during LNG regasification: Electric energy production - Part two

International Nuclear Information System (INIS)

Dispenza, Celidonio; Dispenza, Giorgio; Rocca, Vincenzo La; Panno, Giuseppe

2009-01-01

In liquefied natural gas (LNG) regasification facilities, for exergy recovery during regasification, an option could be the production of electric energy recovering the energy available as cold. In a previous paper, the authors propose an innovative process which uses a cryogenic stream of LNG during regasification as a cold source in an improved combined heat and power (CHP) plant. Considering the LNG regasification projects in progress all over the World, an appropriate design option could be based on a modular unit having a mean regasification capacity of 2 x 10 9 standard cubic meters/year. This paper deals with the results of feasibility studies, developed by the authors at DREAM in the context of a research program, on ventures based on thermodynamic and economic analysis of improved CHP cycles and related innovative technology which demonstrate the suitability of the proposal

Fructokinase activity mediates dehydration-induced renal injury.

Science.gov (United States)

Roncal Jimenez, Carlos A; Ishimoto, Takuji; Lanaspa, Miguel A; Rivard, Christopher J; Nakagawa, Takahiko; Ejaz, A Ahsan; Cicerchi, Christina; Inaba, Shinichiro; Le, MyPhuong; Miyazaki, Makoto; Glaser, Jason; Correa-Rotter, Ricardo; González, Marvin A; Aragón, Aurora; Wesseling, Catharina; Sánchez-Lozada, Laura G; Johnson, Richard J

2014-08-01

The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has been linked with recurrent dehydration. Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently induce renal injury via metabolism by fructokinase. Wild-type and fructokinase-deficient mice were subjected to recurrent heat-induced dehydration. One group of each genotype was provided water throughout the day and the other group was hydrated at night, after the dehydration. Both groups received the same total hydration in 24 h. Wild-type mice that received delayed hydration developed renal injury, with elevated serum creatinine, increased urinary NGAL, proximal tubular injury, and renal inflammation and fibrosis. This was associated with activation of the polyol pathway, with increased renal cortical sorbitol and fructose levels. Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway. Access to sufficient water during the dehydration period can protect mice from developing renal injury. These studies provide a potential mechanism for Mesoamerican nephropathy.

Norcal Prototype LNG Truck Fleet: Final Results

Energy Technology Data Exchange (ETDEWEB)

2004-07-01

U.S. DOE and National Renewable Energy Laboratory evaluated Norcal Waste Systems liquefied natural gas (LNG) waste transfer trucks. Trucks had prototype Cummins Westport ISXG engines. Report gives final evaluation results.

Improving sustainability of maritime transport through utilization of Liquefied Natural Gas (LNG) for propulsion

International Nuclear Information System (INIS)

Burel, Fabio; Taccani, Rodolfo; Zuliani, Nicola

2013-01-01

Today, most merchant vessels use Heavy Fuel Oils (HFOs) for ship propulsion. These fuels are cost effective but they produce significant amounts of noxious emissions. In order to comply with International Maritime Organization (IMO) rules, Liquefied Natural Gas (LNG) is becoming an interesting option for merchant ships. The aim of the research presented in this paper is to analyse the economic upturn that can result from the use of LNG as fuel for merchant ships and to assess the effects of its utilization in terms of environmental impact. In the first part of the study, a statistical analysis of maritime traffic is carried out in order to identify which merchant ship types could most benefit from using LNG as fuel for ship propulsion. Traffic data of world ships related to the months of May 2008, 2009 and 2010 are analysed. Roll-on/Roll-off vessels (RoRo) and tanker ships spend most of their sailing time in Emission Control Areas (ECA) consequently appear to be the best candidates for LNG use. In particular, the use of LNG is most profitable for tanker ships in the range of 10,000–60,000 DWT (deadweight). In the second part of the study, operational costs and pollutant emission reduction, following LNG implementation, are calculated for a 33,000 DWT tanker ship. Results show that LNG leads to a reduction of 35% of operational costs and 25% of CO 2 emissions. The possibility of improving energy efficiency on board is analysed considering that combustion gases, produced by LNG, are cleaner, thus simplifying the introduction of exhaust gas heat recovery. Two options are considered: simple heat recovery and heat recovery to drive a turbine (ORC). The results show that it is possible to achieve a reduction in fuel consumption of up to 15%. - Highlights: • Ship propulsion accounts for a large amount of noxious emissions in costal/harbour areas. • Today price differential between fuel oil and natural gas is increasing. • The use of Liquefied Natural Gas as fuel

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File list: Pol.Lng.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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Applications of human factors engineering to LNG release prevention and control

Energy Technology Data Exchange (ETDEWEB)

Shikiar, R.; Rankin, W.L.; Rideout, T.B.

1982-06-01

The results of an investigation of human factors engineering and human reliability applications to LNG release prevention and control are reported. The report includes a discussion of possible human error contributions to previous LNG accidents and incidents, and a discussion of generic HF considerations for peakshaving plants. More specific recommendations for improving HF practices at peakshaving plants are offered based on visits to six facilities. The HF aspects of the recently promulgated DOT regulations are reviewed, and recommendations are made concerning how these regulations can be implemented utilizing standard HF practices. Finally, the integration of HF considerations into overall system safety is illustrated by a presentation of human error probabilities applicable to LNG operations and by an expanded fault tree analysis which explicitly recognizes man-machine interfaces.

Northwest Asia - gas market outlook: LNG vs. pipeline gas

International Nuclear Information System (INIS)

Keun Wook Paik

1996-01-01

The share of natural gas in Northeast Asia's energy mix is quite low despite that the region currently dominates the world LNG trade. In the long term, the region's rapid expansion of gas demand in the coming decades looks very likely, but the LNG dominance in the region's gas market will collapse in parallel with the introduction of a long distance pipeline gas. The most likely timing of pipeline gas introduction in Northeast Asian gas market seems to be during the second half of the next decade. (Author)

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Boil off gas (BOG) management in Spanish liquid natural gas (LNG) terminals

Energy Technology Data Exchange (ETDEWEB)

Querol, E.; Gonzalez-Regueral, B.; Garcia-Torrent, J.; Garcia-Martinez, M.J. [Departamento de Ingenieria Quimica y Combustibles, Escuela Tecnica Superior de Ingenieros de Minas, Universidad Politecnica de Madrid, c. Alenza 4, 28003 Madrid (Spain)

2010-11-15

Spain is a country with six LNG terminals in operation and three more scheduled for 2011. At the same time an increasing number of LNG tanks are under construction to compensate the Spanish lack of underground storage. A method for evaluating the daily boil off generated is presented in this paper. This method is applied to evaluate the increase of BOG to be handle by LNG terminals in 2016, studying the best commercially available solution to be installed. Finally, as a solution to tackle with the BOG a cogeneration plant is suggested. This option will reduce terminal's operational costs increasing its availability. (author)

Panorama 2016 - LNG in transportation: what is its potential for the sector?

International Nuclear Information System (INIS)

Jordan, Louis

2015-12-01

With low emissions and competitive pricing, liquefied natural gas (LNG) appears to have significant advantages to emerge as an alternative or supplement to traditional fossil fuels. Although LNG has significant potential for growth over the long term, it will have to eliminate some uncertainties, especially those related to supply infrastructure. (author)

Federal cabinet minister from N.B joins opponents to LNG terminals

Energy Technology Data Exchange (ETDEWEB)

Morris, C.

2005-08-25

This article addressed the debate regarding the United States' proposal to construct liquefied natural gas (LNG) facilities on a pristine bay between New Brunswick and Maine. Two LNG projects are currently being promoted for Passamaquoddy Bay, and 2 more proposals are expected to be announced in the near future. However, the proponents have not yet submitted any formal applications to the Canadian government. A federal cabinet minister from New Brunswick has joined the growing opposition to the proposed project, claiming that the location on the Maine side of Passamaquoddy Bay, a large inlet off the Bay of Fundy, poses too many risks to the habitat of several endangered or at-risk species, including the North Atlantic Right Whale. The proposed sites in Maine are directly across a narrow bay where tourism and fishing are prime industries in New Brunswick. The cabinet minister claims that with over 2,000 miles of coastline on the eastern seaboard, another location can be found for the LNG facilities that would not present navigational difficulties. The Canadian federal government has the jurisdiction to stop the project by not allowing the supertankers to cross Canadian waters to enter the Bay. The waters are known for their treacherous navigation. The premier of New Brunswick has also stepped in to ensure that the governor of Maine is made aware of Canada's opposition to the project. Officials with Downeast LNG and Quoddy Bay LLC claim there would not be any safety or environmental risks associated with the LNG project.

The LNG industry in 2011. Press revue

International Nuclear Information System (INIS)

2012-05-01

The outlook of the LNG industry in 2011 is presented as a revue of press articles: The role of LNG as a flexible and secure energy source as well as the prompt response to provide back-up through additional supplies and cargo diversions to compensate for the sudden loss of nuclear capacity in Japan - with sellers exercising due price restraint in view of the human tragedy - has been a credit to the industry. The increase in production capacity in 2009 and 2010, in particular from Qatar, had permitted the necessary buffer to cope much better with the demand surge than during past disruptions (such as the aftermath of the Chuetsu earthquake in late 2007). Undoubtedly, the marked shift over the last decade in the industry's prevailing business model towards global trade, destination flexibility and portfolio play has also facilitated the rapid response. As the total volume of LNG trade is very much determined by the availability of supply, 2011 has seen a growth of 9.4% over 2010, mainly as a result of the full availability of the six Qatar mega-trains over the past year. On the demand side the two traditional basins have shown very contrasting trends: 15% higher LNG off-take in Asia (the five major markets all increasing between 37.4% and 8.9%), versus a 1.7% decrease in the Atlantic Basin. Cargo diversions and an increasing number of reloads have boosted the exports from the Atlantic Basin to Asia in 2011 to more than 14 million tons (equivalent to more than 200 large size cargoes). Remarkable is also the fast growth in new markets in Latin America and in the Middle East - albeit from a small base - with counter-seasonal but varying demand, offering attractive arbitrage opportunities to portfolio play. Not surprising then that 2011 has seen another hike in spot and short-term trade, not just in absolute terms but also as a percentage of total trade (50% over 2010, 25.4% of total trade). The outlook for LNG is strong and its global demand prospects further

Traditional Chinese Medicine and Herb-induced Liver Injury: Comparison with Drug-induced Liver Injury.

Science.gov (United States)

Jing, Jing; Teschke, Rolf

2018-03-28

Cases of suspected herb-induced liver injury (HILI) caused by herbal Traditional Chinese Medicines (TCMs) and of drug-induced liver injury (DILI) are commonly published in the scientific literature worldwide. As opposed to the multiplicity of botanical chemicals in herbal TCM products, which are often mixtures of several herbs, conventional Western drugs contain only a single synthetic chemical. It is therefore of interest to study how HILI by TCM and DILI compare with each other, and to what extent results from each liver injury type can be transferred to the other. China is among the few countries with a large population using synthetic Western drugs as well as herbal TCM. Therefore, China is well suited to studies of liver injury comparing drugs with TCM herbs. Despite some concordance, recent analyses of liver injury cases with verified causality, using the Roussel Uclaf Causality Assessment Method, revealed major differences in HILI caused by TCMs as compared to DILI with respect to the following features: HILI cases are less frequently observed as compared to DILI, have a smaller proportion of females and less unintentional rechallenge events, and present a higher rate of hepatocellular injury features. Since many results were obtained among Chinese residents who had access to and had used Western drugs and TCM herbs, such ethnic homogeneity supports the contention that the observed differences of HILI and DILI in the assessed population are well founded.

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Suramin protects from cisplatin-induced acute kidney injury

Science.gov (United States)

Dupre, Tess V.; Doll, Mark A.; Shah, Parag P.; Sharp, Cierra N.; Kiefer, Alex; Scherzer, Michael T.; Saurabh, Kumar; Saforo, Doug; Siow, Deanna; Casson, Lavona; Arteel, Gavin E.; Jenson, Alfred Bennett; Megyesi, Judit; Schnellmann, Rick G.; Beverly, Levi J.

2015-01-01

Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from kidney injury, and there are limited treatment options for the treatment of cisplatin-induced kidney injury. Suramin, which is Federal Drug Administration-approved for the treatment of trypanosomiasis, improves kidney function after various forms of kidney injury in rodent models. We hypothesized that suramin would attenuate cisplatin-induced kidney injury. Suramin treatment before cisplatin administration reduced cisplatin-induced decreases in kidney function and injury. Furthermore, suramin attenuated cisplatin-induced expression of inflammatory cytokines and chemokines, endoplasmic reticulum stress, and apoptosis in the kidney cortex. Treatment of mice with suramin 24 h after cisplatin also improved kidney function, suggesting that the mechanism of protection is not by inhibition of tubular cisplatin uptake or its metabolism to nephrotoxic species. If suramin is to be used in the context of cancer, then it cannot prevent cisplatin-induced cytotoxicity of cancer cells. Suramin did not alter the dose-response curve of cisplatin in lung adenocarcinoma cells in vitro. In addition, suramin pretreatment of mice harboring lung adenocarcinomas did not alter the initial cytotoxic effects of cisplatin (DNA damage and apoptosis) on tumor cells. These results provide evidence that suramin has potential as a renoprotective agent for the treatment/prevention of cisplatin-induced acute kidney injury and justify future long-term preclinical studies using cotreatment of suramin and cisplatin in mouse models of cancer. PMID:26661653

Optimal LNG (liquefied natural gas) regasification scheduling for import terminals with storage

International Nuclear Information System (INIS)

Trotter, Ian M.; Gomes, Marília Fernandes Maciel; Braga, Marcelo José; Brochmann, Bjørn; Lie, Ole Nikolai

2016-01-01

We describe a stochastic dynamic programming model for maximising the revenue generated by regasification of LNG (liquefied natural gas) from storage tanks at importation terminals in relation to a natural gas spot market. We present three numerical resolution strategies: a posterior optimal strategy, a rolling intrinsic strategy and a full option strategy based on a least-squares Monte Carlo algorithm. We then compare model simulation results to the observed behaviour of three LNG importation terminals in the UK for the period April 2011 to April 2012, and find that there was low correlation between the observed regasification decisions of the operators and those suggested by the three simulated strategies. However, the actions suggested by the model simulations would have generated significantly higher revenues, suggesting that the facilities might have been operated sub-optimally. A further numerical experiment shows that increasing the storage and regasification capacities of a facility can significantly increase the achievable revenue, even without altering the amount of LNG received, by allowing operators more flexibility to defer regasification. - Highlights: • We present a revenue maximisation model for LNG (liquefied natural gas) storage tanks at import terminals. • Three resolution strategies: posterior optimal, rolling intrinsic and full option. • The full option strategy is based on a least-squares Monte Carlo algorithm. • Model simulations show potential for higher revenue in three UK LNG terminals. • Numerical experiments show how storage and regasification capacities affect revenue.

Improved processes of light hydrocarbon separation from LNG with its cryogenic energy utilized

International Nuclear Information System (INIS)

Gao Ting; Lin Wensheng; Gu Anzhong

2011-01-01

Research highlights: → We propose two new light hydrocarbon separation processes utilizing LNG cold energy. → Both processes produce liquefied ethane and LPG with high ethane recovery rate. → CH 4 -riched gas from the high pressure process is compressed to final pressure. → Re-liquefied CH 4 -riched gas from the low pressure one is pumped to final pressure. → Both processes have good performance; the low pressure one is economically better. -- Abstract: Liquefied natural gas (LNG) often consists of some kinds of light hydrocarbons other than methane, such as ethane, propane and butane, which are of high additional value. By efficiently utilization of LNG cryogenic energy, these light hydrocarbons (C 2 + ) can be separated from LNG with low power consumption and LNG is gasified meanwhile. Two novel light hydrocarbon separation processes are proposed in this paper. The first process uses a demethanizer working at higher pressure (about 4.5 MPa). The methane-riched natural gas from the demethanizer can be compressed to pipeline pressure with low power consumption. The other one uses a demethanizer working at lower pressure (about 2.4 MPa). By cascade utilization of LNG cryogenic energy, the methane-riched natural gas from the demethanizer is entirely re-liquefied. Then the liquid product is pressurized to pipeline pressure by pumps instead of compressors, reducing the power consumption greatly. By both of the two processes, liquefied ethane and LPG (liquefied petroleum gas, i.e. C 3 + ) at atmosphere pressure can be obtained directly, and high ethane recovery rate can be gained. On the basis of one typical feed gas composition, the effects of the ethane content and the ethane price to the economics of the light hydrocarbon separation plants are studied, and the economics are compared for these two processes. The results show that recovering light hydrocarbons from LNG can gain great profits by both of the two processes, and from the view of economics, the

In-situ strain monitoring in liquid containers of LNG transporting carriers

Science.gov (United States)

Oh, Min-Cheol; Seo, Jun-Kyu; Kim, Kyung-Jo; Lee, Sang-Min; Kim, Myung-Hyun

2008-08-01

Liquefied natural gas (LNG) transport carriers are exposed to a risk by the repeated bump in the LNG container during the vessel traveling over the wave in ocean. The liquid inside the container, especially when it was not fully contained, make a strong bump onto the insulation panel of the tank wall. The insulation panel consists of several layers of thick polyurethane foam (PUF) to maintain the LNG below the cryogenic temperature, -162°C. Due to the repeated shock on the PUF, a crack could be developed on the tank wall causing a tremendous disaster for LNG carriers. To prevent the accidental crack on the tank, a continuous monitoring of the strain imposed on the PUF is recommended. In this work, a fiber-optic Bragg grating was imbedded inside the PUF for monitoring the strain parallel to the impact direction. The optical fiber sensor with a small diameter of 125 μm was suitable to be inserted in the PUF through a small hole drilled after the PUF was cured. In-situ monitoring of the strain producing the change of Bragg reflection wavelength, a high speed wavelength interrogation method was employed by using an arrayed waveguide grating. By dropping a heavy mass on the PUF, we measured the strain imposed on the insulation panel.

Natural gas and CO2 price variation: impact on the relative cost-efficiency of LNG and pipelines.

Science.gov (United States)

Ulvestad, Marte; Overland, Indra

2012-06-01

THIS ARTICLE DEVELOPS A FORMAL MODEL FOR COMPARING THE COST STRUCTURE OF THE TWO MAIN TRANSPORT OPTIONS FOR NATURAL GAS: liquefied natural gas (LNG) and pipelines. In particular, it evaluates how variations in the prices of natural gas and greenhouse gas emissions affect the relative cost-efficiency of these two options. Natural gas is often promoted as the most environmentally friendly of all fossil fuels, and LNG as a modern and efficient way of transporting it. Some research has been carried out into the local environmental impact of LNG facilities, but almost none into aspects related to climate change. This paper concludes that at current price levels for natural gas and CO 2 emissions the distance from field to consumer and the volume of natural gas transported are the main determinants of transport costs. The pricing of natural gas and greenhouse emissions influence the relative cost-efficiency of LNG and pipeline transport, but only to a limited degree at current price levels. Because more energy is required for the LNG process (especially for fuelling the liquefaction process) than for pipelines at distances below 9100 km, LNG is more exposed to variability in the price of natural gas and greenhouse gas emissions up to this distance. If the prices of natural gas and/or greenhouse gas emission rise dramatically in the future, this will affect the choice between pipelines and LNG. Such a price increase will be favourable for pipelines relative to LNG.

Monitoring and analysis of liquid storage in LNG tank based on different support springs

Science.gov (United States)

He, Hua; Sun, Jianping; Li, Ke; Wu, Zheng; Chen, Qidong; Chen, Guodong; Cao, Can

2018-04-01

With the rapid development of social modernization, LNG vehicles are springing up in daily life. However, it is difficult to monitor and judge the liquid storage tanks accurately and quickly. Based on this, this paper presents a new method of liquid storage monitoring, LNG tank on-line vibration monitoring system. By collecting the vibration frequency of LNG tank and tank liquid and supporting spring system, the liquid storage quality in the tank can be calculated. In this experiment, various vibration modes of the tank spring system are fully taken into account. The vibration effects of different types of support springs on the LNG tank system were investigated. The results show that the spring model has a great influence on the test results. This study provides a technical reference for the selection of suitable support springs for liquid storage monitoring.

Radiation-induced heart injury. Radiopathological study

Energy Technology Data Exchange (ETDEWEB)

Suzuki, Y; Niibe, H [Gunma Univ., Maebashi (Japan). School of Medicine

1975-11-01

In order to identify radiation-induced heart injury and to differentiate it from heart disease, an attempt was made to clarify post-irradiation heart injury by investigating the histological changes which occur during the interval between the irradiation and the time of demonstrable histological changes. A study was made of 83 autopsies in which most of the primary neoplasms were breast cancers, lung cancers and mediastinal tumors. In 43 of these autopsies the heart had been irradiated. Sixty eight dd-strain mice were also used for microautoradiographic study. Histological changes in the heart were observed in 27 of the 43 cases receiving irradiation. The limit of the tolerance dose to the heart for indicating histological changes was 1220 ret in humans. The latent period without histological changes was 2.7 months after initiation of radiation therapy. Greater heart injury was observed after re-irradiation or after the combined therapy of radiation and chemotherapy especially mitomycin (MMC). The histological findings after treatment with MMC were similar to those of radiation-induced heart injury. Results of the study indicate that the damage is secondary to radiation-induced changes of the vascula connective tissue.

A structural and stochastic optimal model for projections of LNG imports and exports in Asia-Pacific

Directory of Open Access Journals (Sweden)

Tom Kompas

2016-06-01

Full Text Available The Asia-Pacific region, the largest and fastest growing liquefied natural gas (LNG market in the world, has been undergoing radical changes over the past few years. These changes include considerable additional supplies from North America and Australia, and a recent LNG price slump resulting from an oil-linked pricing mechanism and demand uncertainties. This paper develops an Asia-Pacific Gas Model (APGM, based on a structural, stochastic and optimising framework, providing a valuable tool for the projection of LNG trade in the Asia-Pacific region. With existing social-economic conditions, the model projects that Asia-Pacific LNG imports are expected to increase by 49.1 percent in 2020 and 95.7 percent in 2030, compared to 2013. Total LNG trade value is estimated to increase to US$127.2 billion in 2020 and US$199.0 billion in 2030. Future LNG trade expansion is mainly driven by emerging and large importers (i.e., China and India, and serviced, most importantly, by new supplies from Australia and the USA. The model's projected results are sensitive to changes in expected oil prices, pricing mechanisms, economic growth and energy policies, as well as unexpected geopolitical-economic events.

File list: InP.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

Lifescience Database Archive (English)

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Dossier LNG. Liquid market move

International Nuclear Information System (INIS)

Matla, P.

2012-01-01

The worldwide market for liquid natural gas is booming like never before and the end is not in sight yet. Shell is market leader among international energy companies. But where does LNG come from? And how will the fuel be used in the coming years? What role does Shell want to play in this market? These questions are addressed in a series of three articles. [nl

33 CFR 165.1709 - Security Zones: Liquefied Natural Gas Tanker Transits and Operations at Phillips Petroleum LNG...

Science.gov (United States)

2010-07-01

... Gas Tanker Transits and Operations at Phillips Petroleum LNG Pier, Cook Inlet, AK. 165.1709 Section...: Liquefied Natural Gas Tanker Transits and Operations at Phillips Petroleum LNG Pier, Cook Inlet, AK. (a... and outbound transits through Cook Inlet, Alaska between the Phillips Petroleum LNG Pier, 60°40′43″ N...

Montelukast induced acute hepatocellular liver injury

Directory of Open Access Journals (Sweden)

Harugeri A

2009-01-01

Full Text Available A 46-year-old male with uncontrolled asthma on inhaled albuterol and formoterol with budesonide was commenced on montelukast. He developed abdominal pain and jaundice 48 days after initiating montelukast therapy. His liver tests showed an increase in serum total bilirubin, conjugated bilirubin, aspartate aminotranferase, alanine aminotranferase, and alkaline phosphatase. The patient was evaluated for possible non-drug related liver injury. Montelukast was discontinued suspecting montelukast induced hepatocellular liver injury. Liver tests began to improve and returned to normal 55 days after drug cessation. Causality of this adverse drug reaction by the Council for International Organizations of Medical Sciences or Roussel Uclaf Causality Assessment Method (CIOMS or RUCAM and Naranjo′s algorithm was ′probable′. Liver tests should be monitored in patients receiving montelukast and any early signs of liver injury should be investigated with a high index of suspicion for drug induced liver injury.

File list: NoD.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

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File list: NoD.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

Lifescience Database Archive (English)

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File list: InP.Lng.20.Input_control.AllCell [Chip-atlas[Archive

Lifescience Database Archive (English)

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File list: InP.Lng.10.Input_control.AllCell [Chip-atlas[Archive

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File list: InP.Lng.05.Input_control.AllCell [Chip-atlas[Archive

Lifescience Database Archive (English)

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File list: InP.Lng.50.Input_control.AllCell [Chip-atlas[Archive

Lifescience Database Archive (English)

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Future forecast for life-cycle greenhouse gas emissions of LNG and city gas 13A

International Nuclear Information System (INIS)

Okamura, Tomohito; Furukawa, Michinobu; Ishitani, Hisashi

2007-01-01

The objective of this paper is to analyze the most up-to-date data available on total greenhouse-gas emissions of a LNG fuel supply chain and life-cycle of city gas 13A based on surveys of the LNG projects delivering to Japan, which should provide useful basic-data for conducting life-cycle analyses of other product systems as well as future alternative energy systems, because of highly reliable data qualified in terms of its source and representativeness. In addition, the life-cycle greenhouse-gas emissions of LNG and city-gas 13A in 2010 were also predicted, taking into account not only the improvement of technologies, but also the change of composition of LNG projects. As a result of this analysis, the total amount of greenhouse-gas emissions of the whole city-gas 13A chain at present was calculated to be 61.91 g-CO 2 /MJ, and the life-cycle greenhouse-gas emissions of LNG and city-gas 13A in 2010 could be expected to decrease by about 1.1% of the current emissions

US North Slope gas and Asian LNG markets

Science.gov (United States)

Attanasi, E.D.

1994-01-01

Prospects for export of liquified natural gas (LNG) from Alaska's North Slope are assessed. Projected market conditions to 2010 show that new LNG capacity beyond announced expansions will be needed to meet regional demand and that supplies will probably come from outside the region. The estimated delivered costs of likely suppliers show that Alaska North Slope gas will not be competitive. The alternative North Slope gas development strategies of transport and sale to the lower 48 states and use on the North Slope for either enhanced oil recovery or conversion to liquids are examined. The alternative options require delaying development until US gas prices increase, exhaustion of certain North Slope oil fields, or advances occur in gas to liquid fuels conversion technology. ?? 1995.

Current status and future projections of LNG demand and supplies: A global prospective

International Nuclear Information System (INIS)

Kumar, Satish; Kwon, Hyouk-Tae; Choi, Kwang-Ho; Hyun Cho, Jae; Lim, Wonsub; Moon, Il

2011-01-01

An unceasing growth of gas consumption in domestic households, industry, and power plants has gradually turned natural gas into a major source of energy. Main drivers in this development are the technical and economic advantages of natural gas. It is a clean, versatile, and easily controllable fuel. On this basis, natural gas is often considered the form of energy that will be the 'bridging fuel' to a sustainable energy system, sometime after 2050. Unlike other main sources of energy, such as oil and coal, gas is not traded on an actual world market. This paper provides an overview on demand and supplies of natural gas (LNG) in the past as a function of gas prices, gas technology (gas sweetening, liquefaction, shipping and re-gasification), and gas market and how they have changed recently. It also discusses the likely developments in global LNG demand for the period to the year 2030. - Highlights: → This study provides an overview on demand and supplies of LNG in the past and future. → Outlook for LNG demand in Asia pacific region is very robust. → In past decade the shale gas production in USA has increased fivefold. → The future of European gas supply depends largely on the geopolitical environments. → Within the gas sector LNG is playing an ever increasing role in gas transportation.

Induced hypernatraemia is protective in acute lung injury.

Science.gov (United States)

Bihari, Shailesh; Dixon, Dani-Louise; Lawrence, Mark D; Bersten, Andrew D

2016-06-15

Sucrose induced hyperosmolarity is lung protective but the safety of administering hyperosmolar sucrose in patients is unknown. Hypertonic saline is commonly used to produce hyperosmolarity aimed at reducing intra cranial pressure in patients with intracranial pathology. Therefore we studied the protective effects of 20% saline in a lipopolysaccharide lung injury rat model. 20% saline was also compared with other commonly used fluids. Following lipopolysaccharide-induced acute lung injury, male Sprague Dawley rats received either 20% hypertonic saline, 0.9% saline, 4% albumin, 20% albumin, 5% glucose or 20% albumin with 5% glucose, i.v. During 2h of non-injurious mechanical ventilation parameters of acute lung injury were assessed. Hypertonic saline resulted in hypernatraemia (160 (1) mmol/l, mean (SD)) maintained through 2h of ventilation, and in amelioration of lung oedema, myeloperoxidase, bronchoalveolar cell infiltrate, total soluble protein and inflammatory cytokines, and lung histological injury score, compared with positive control and all other fluids (p ≤ 0.001). Lung physiology was maintained (conserved PaO2, elastance), associated with preservation of alveolar surfactant (p ≤ 0.0001). Independent of fluid or sodium load, induced hypernatraemia is lung protective in lipopolysaccharide-induced acute lung injury. Copyright © 2016 Elsevier B.V. All rights reserved.

Overview of the LNG world market; Panorama mundial do mercado de GNL

Energy Technology Data Exchange (ETDEWEB)

Veloso, Luciano de Gusmao; Costa, Julia Rotstein Smith da Silva; Moreira, Tathiany Rodrigues [Agencia Nacional do Petroleo, Gas Natural e Biocombustiveis (ANP), Rio de Janeiro, RJ (Brazil)

2008-07-01

The commercialization of Liquefied Natural Gas (LNG) has been gaining great prominence worldwide and in Brazil, in recent days, due to the ever-increasing need for diversification of energy sources and for flexibilization of gas offer, in order to ensure the importing countries' supply. In this scenario, LNG has been positioning itself, around the world, as an important alternative, especially in cases where there is uncertainty concerning the fulfillment of delivery contracts, the transportation network is still incipient or inexistent, the gas pipelines operate at full capacity and the country's gas demand is met by more than one exporting source, sometimes by different transport modals. In the case of Brazil, the recent restrictions to the gas offer bring to the agenda the search for better solutions in energy policy in order to appropriately meet the totality of national demand. This article presents the current situation of the LNG market and identifies the main agents involved in its commerce, drawing attention to, in light of the originality of LNG projects in Brazil, the need for perfecting the regulation in order to boost the development of the national gas industry. (author)

More LNG ship orders for GD (General Dynamics Corp. )

Energy Technology Data Exchange (ETDEWEB)

1977-09-01

General Dynamics Corp. has been awarded a contract for two LNG tankers to transport LNG from Algeria to Lake Charles, La., with the U.S. Maritime Administration funding 25.5% of the $155 million cost of each vessel. The two ships are being built for Lachmar Inc., of Delaware, a partnership composed of Morgas Inc., Pantheon Inc., and Pelmar Inc., subsidiaries respectively of Moore-McCormack Bulk Transport Inc., General Dynamics Corp., and Panhandle Eastern Pipe Line Co. Upon completion in Dec. 1979 and Mar. 1980, the ships will be operated by Gastrans Inc. of Delaware, which is also a subsidiary of Moore-McCormack.

China's energy and environmental quandary: is LNG the answer?

International Nuclear Information System (INIS)

Williams, M.F.; King, B.S.

1996-01-01

Economic growth in China has inevitably lead to an increased energy demand to fuel industrial production, infrastructural and domestic needs. To date much of China's generating capacity has been coal-based, without flue gas desulphurisation. The serious environmental effects of such a policy are being reexamined in the light of rapid growth in demand. This paper argues that power generation by combined cycle gas turbines and fuelled by natural gas, supplied as LNG could provide a solution. Imported LNG to fuel such turbines could, it is argued, be used to generate electricity at prices competitive with imported coal and other sources of domestic gas. (UK)

File list: His.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

Lifescience Database Archive (English)

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Blanketing effect of expansion foam on liquefied natural gas (LNG) spillage pool

Energy Technology Data Exchange (ETDEWEB)

Zhang, Bin; Liu, Yi [Mary Kay O’Connor Process Safety Center, Artie McFerrin Department of Chemical Engineering, Texas A and M University System, College Station, TX 77843-3122 (United States); Olewski, Tomasz; Vechot, Luc [Mary Kay O’Connor Process Safety Center - Qatar, Texas A and M University at Qatar, PO Box 23874, Doha (Qatar); Mannan, M. Sam, E-mail: mannan@tamu.edu [Mary Kay O’Connor Process Safety Center, Artie McFerrin Department of Chemical Engineering, Texas A and M University System, College Station, TX 77843-3122 (United States)

2014-09-15

Highlights: • Reveal the existence of blocking effect of high expansion foam on an LNG pool. • Study the blanketing effect of high expansion foam quantitatively. • Correlate heat flux for vaporization with foam breaking rate. • Propose the physical mechanism of blanketing effect. - Abstract: With increasing consumption of natural gas, the safety of liquefied natural gas (LNG) utilization has become an issue that requires a comprehensive study on the risk of LNG spillage in facilities with mitigation measures. The immediate hazard associated with an LNG spill is the vapor hazard, i.e., a flammable vapor cloud at the ground level, due to rapid vaporization and dense gas behavior. It was believed that high expansion foam mitigated LNG vapor hazard through warming effect (raising vapor buoyancy), but the boil-off effect increased vaporization rate due to the heat from water drainage of foam. This work reveals the existence of blocking effect (blocking convection and radiation to the pool) to reduce vaporization rate. The blanketing effect on source term (vaporization rate) is a combination of boil-off and blocking effect, which was quantitatively studied through seven tests conducted in a wind tunnel with liquid nitrogen. Since the blocking effect reduces more heat to the pool than the boil-off effect adds, the blanketing effect contributes to the net reduction of heat convection and radiation to the pool by 70%. Water drainage rate of high expansion foam is essential to determine the effectiveness of blanketing effect, since water provides the boil-off effect.

Blanketing effect of expansion foam on liquefied natural gas (LNG) spillage pool

International Nuclear Information System (INIS)

Zhang, Bin; Liu, Yi; Olewski, Tomasz; Vechot, Luc; Mannan, M. Sam

2014-01-01

Highlights: • Reveal the existence of blocking effect of high expansion foam on an LNG pool. • Study the blanketing effect of high expansion foam quantitatively. • Correlate heat flux for vaporization with foam breaking rate. • Propose the physical mechanism of blanketing effect. - Abstract: With increasing consumption of natural gas, the safety of liquefied natural gas (LNG) utilization has become an issue that requires a comprehensive study on the risk of LNG spillage in facilities with mitigation measures. The immediate hazard associated with an LNG spill is the vapor hazard, i.e., a flammable vapor cloud at the ground level, due to rapid vaporization and dense gas behavior. It was believed that high expansion foam mitigated LNG vapor hazard through warming effect (raising vapor buoyancy), but the boil-off effect increased vaporization rate due to the heat from water drainage of foam. This work reveals the existence of blocking effect (blocking convection and radiation to the pool) to reduce vaporization rate. The blanketing effect on source term (vaporization rate) is a combination of boil-off and blocking effect, which was quantitatively studied through seven tests conducted in a wind tunnel with liquid nitrogen. Since the blocking effect reduces more heat to the pool than the boil-off effect adds, the blanketing effect contributes to the net reduction of heat convection and radiation to the pool by 70%. Water drainage rate of high expansion foam is essential to determine the effectiveness of blanketing effect, since water provides the boil-off effect

Biomarkers of drug-induced vascular injury

International Nuclear Information System (INIS)

Brott, D.; Gould, S.; Jones, H.; Schofield, J.; Prior, H.; Valentin, J.P; Bjurstrom, S.; Kenne, K.; Schuppe-Koistinen, I.; Katein, A.; Foster-Brown, L.; Betton, G.; Richardson, R.; Evans, G.; Louden, C.

2005-01-01

In pre-clinical safety studies, drug-induced vascular injury is an issue of concern because there are no obvious diagnostic markers for pre-clinical or clinical monitoring and there is an intellectual gap in our understanding of the pathogenesis of this lesion. While vasodilatation and increased shear stress appear to play a role, the exact mechanism(s) of injury to the primary targets, smooth muscle and endothelial cells are unknown. However, evaluation of novel markers for potential clinical monitoring with a mechanistic underpinning would add value in risk assessment and management. This mini review focuses on the progress to identify diagnostic markers of drug-induced vascular injury. Von Willebrand factor (vWF), released upon perturbation of endothelial cells, is transiently increased in plasma prior to morphological evidence of damage in dogs or rats treated with vascular toxicants. Therefore, vWF might be a predictive biomarker of vascular injury. However, vWF is not an appropriate biomarker of lesion progression or severity since levels return to baseline values when there is morphological evidence of injury. A potential mechanistically linked biomarker of vascular injury is caveolin-1. Expression of this protein, localized primarily to smooth muscle and endothelial cells, decreases with the onset of vascular damage. Since vascular injury involves multiple mediators and cell types, evaluation of a panel rather than a single biomarker may be more useful in monitoring early and severe progressive vascular injury

White paper: Preliminary assessment of LNG vehicle technology, economics, and safety issues (Revision 1). Topical report, April-August 1991

International Nuclear Information System (INIS)

Powars, C.; Lucher, D.; Moyer, C.; Browning, L.

1992-01-01

The objective of the study is to evaluate the potential of LNG as a vehicle fuel, to determine market niches, and to identify needed technology improvements. The white paper is being issued when the work is approximately 30 percent complete to preview the study direction, draw preliminary conclusions, and make initial recommendations. Interim findings relative to LNG vehicle technology, economics, and safety are presented. It is important to decide if heavier hydrocarbons should be allowed in LNG vehicle fuel. Development of suitable refueling couplings and vehicle fuel supply pressure systems are recommended. Initial economics analyses considered transit buses and pickup and delivery trucks fueled via onsite liquefiers and imported LNG. Net user costs were more than (but in some cases close to) those for diesel fuel and gasoline. Lowering the cost of small-scale liquefiers would significantly improve the economics of LNG vehicles. New emissions regulations may introduce considerations beyond simple cost comparisons. LNG vehicle safety and available accident data are reviewed. Consistent codes for LNG vehicles and refueling facilities are needed

Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury.

Directory of Open Access Journals (Sweden)

Julie Wagner

Full Text Available Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species, release of pro-inflammatory cytokines, and transmigration as well as activation of neutrophil cells, are needed to improve the clinical outcome of ventilated patients. Though the inhaled anesthetic sevoflurane is known to exert organ-protective effects, little is known about the potential of sevoflurane therapy in ventilator-induced lung injury. This study focused on the effects of delayed sevoflurane application in mechanically ventilated C57BL/6N mice. Lung function, lung injury, oxidative stress, and inflammatory parameters were analyzed and compared between non-ventilated and ventilated groups with or without sevoflurane anesthesia. Mechanical ventilation led to a substantial induction of lung injury, reactive oxygen species production, pro-inflammatory cytokine release, and neutrophil influx. In contrast, sevoflurane posttreatment time dependently reduced histological signs of lung injury. Most interestingly, increased production of reactive oxygen species was clearly inhibited in all sevoflurane posttreatment groups. Likewise, the release of the pro-inflammatory cytokines interleukin-1β and MIP-1β and neutrophil transmigration were completely prevented by sevoflurane independent of the onset of sevoflurane administration. In conclusion, sevoflurane posttreatment time dependently limits lung injury, and oxidative and pro-inflammatory responses are clearly prevented by sevoflurane irrespective of the onset of posttreatment. These findings underline the therapeutic potential of sevoflurane treatment in ventilator-induced lung injury.

Effects of quercetin on kidney injury induced by doxorubicin.

Science.gov (United States)

Yagmurca, M; Yasar, Z; Bas, O

2015-01-01

The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be nephrotoxic to humans. The aim of present study was to determine the protective effects of quercetin against doxorubicin-induced kidney injury with light microscopy. Forty male Wistar albino rats were divided into four groups: control, doxorubicin, doxorubicin+quercetin and quercetin. A single dose of 20 mg/kg/ i.p. doxorubicin was used to induce injury. Quercetin was administrated orally against doxorubicin toxicity. The kidneys were examined under light microscopy after H-E (hematoxylin-eosin) staining and the changes were scored. Significant tissue injury was observed in doxorubicin-administered group. Among these injuries, renal tubular dilatation, tubular vacuolar changes, glomerular vacuolization, decrease in bowman space, bowman capsule thickening, and interstitial infiltration were evident. However, the injury induced by doxorubicin was attenuated with quercetin administration. Quercetin decreased doxorubicin-induced kidney damage (Tab. 1, Fig. 4, Ref. 27).

76 FR 77814 - Cameron LNG, LLC; Notice of Intent To Prepare an Environmental Assessment for the Proposed BOG...

Science.gov (United States)

2011-12-14

.... Summary of the Proposed Project Cameron LNG plans to construct and operate facilities necessary to liquefy boil-off gas (BOG) at its existing liquefied natural gas (LNG) terminal in Cameron Parish, Louisiana... sufficient LNG in each of the terminal's storage tanks. Currently, BOG is sent out via delivery into the...

File list: InP.Lng.50.AllAg.WI-38 [Chip-atlas[Archive

Lifescience Database Archive (English)

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Review of sport-induced groin injuries.

Science.gov (United States)

Sedaghati, Parisa; Alizadeh, Mohammad-Hossein; Shirzad, Elham; Ardjmand, Abolfazl

2013-12-01

Groin injuries are among the most common injuries co-existing with sports. The aim of this review was to outline the epidemiology and identify risk factors, as well as examine preventative and interventional measures for reducing the occurrence of this form of injury among athletes. An electronic, systematic search for relevant keywords, either separately or in combination was sought in the academic scientific databases. Groin injuries, acute or chronic, consist of a high percentage of injuries that manifest with pain. Despite the specific tendency for injury among some sports, such injuries make up 2-5% of sport-induced injuries. There are few available reports on lower limb injuries, especially groin injuries, in Iran. Numerous factors predispose to groin injuries. A lengthy list of preventive/ treatment measures, from preliminary to sophisticated, have been proposed. Although using a programmed strategy designed to decrease the risk of groin injuries by taking a strategic approach to exercise may alleviate complications, in some cases the chronic nature of the injury may threaten the professional life of the athlete. More research is required to plan suitable programs for reducing the risk of this type of injury in athletes.

Flexible LNG supply, storage and price formation in a global natural gas market

Science.gov (United States)

Hayes, Mark Hanley

The body of work included in this dissertation explores the interaction of the growing, flexible liquefied natural gas (LNG) trade with the fundamentals of pipeline gas supply, gas storage, and gas consumption. By nature of its uses---largely for residential heating and electric power generation---the consumption of natural gas is highly variable both seasonally and on less predictable daily and weekly timescales. Flexible LNG trade will interconnect previously isolated regional gas markets, each with non-correlated variability in gas demand, differing gas storage costs, and heterogeneous institutional structures. The dissertation employs a series of analytical models to address key issues that will affect the expansion of the LNG trade and the implications for gas prices, investment and energy policy. First, I employ an optimization model to evaluate the fundamentals of seasonal LNG swing between markets with non-correlated gas demand (the U.S. and Europe). The model provides insights about the interaction of LNG trade with gas storage and price formation in interconnected regional markets. I then explore how random (stochastic) variability in gas demand will drive spot cargo movements and covariation in regional gas prices. Finally, I analyze the different institutional structures of the gas markets in the U.S. and Europe and consider how managed gas markets in Europe---without a competitive wholesale gas market---may effectively "export" supply and price volatility to countries with more competitive gas markets, such as the U.S.

LNG as vehicle fuel and the problem of supply: The Italian case study

International Nuclear Information System (INIS)

Arteconi, A.; Polonara, F.

2013-01-01

The transport sector represents a major item on the global balance of greenhouse gas (GHG) emissions. Natural gas is considered the alternative fuel that, in the short-medium term, can best substitute conventional fuels in order to reduce their environmental impact, because it is readily available at a competitive price, using technologies already in widespread use. It can be used as compressed gas (CNG) or in the liquid phase (LNG), being the former more suitable for light vehicles, while the latter for heavy duty vehicles. The purpose of this paper is to outline the potential of LNG as vehicle fuel, showing positive and negative aspects related to its introduction and comparing the different supply options with reference to the Italian scenario, paying particular attention to the possibility of on site liquefaction. The analysis has highlighted that purchasing LNG at the regasification terminal is convenient up to a terminal distance of 2000 km from the refuelling station. The liquefaction on site, instead, asks for liquefaction efficiency higher than 70% and low natural gas price and, as liquefaction technology, the let-down plants at the pressure reduction points along the pipeline are the best option to compete with direct supply at the terminal. -- Highlights: •LNG potential as vehicles fuel is analysed. •A SWOT analysis for LNG introduction in the Italian market is presented. •An economic comparison of different supply options is performed. •Possible micro-scale liquefaction technologies are evaluated

The influence of the technologically advanced evacuation models on the risk analyses during accidents in LNG terminal

Energy Technology Data Exchange (ETDEWEB)

Stankovicj, Goran; Petelin, Stojan [Faculty for Maritime Studies and Transport, University of Ljubljana, Portorozh (Sierra Leone); others, and

2014-07-01

The evacuation of people located in different safety zones of an LNG terminal is a complex problem considering that the accidents involving LNG are very hazardous and post the biggest threat to the safety of the people located near the LNG leakage. The safety risk criteria define the parameters which one LNG terminal should meet in terms of safety. Those criteria also contain an evacuation as an evasive action with the objective to mitigate the influence of the LNG accident on the people at risk. Till date, not a lot of attention has been paid to technologically advanced evacuations intended for LNG terminals. Creating the technologically advanced evacuation influences directly on the decrease of the probability of fatalities P{sub f,i}, thus influencing the calculation of the individual risk as well as the societal risk which results in the positioning of the F-N curve in the acceptable part of the ALARP zone. With this paper, we aim to present the difference between the safety analyses in cases when conservative data for P{sub f,i} is being used while calculating the risk, and in cases when real data for P{sub f,i} is been used. (Author)

File list: His.Lng.20.AllAg.Lung_adenocarcinoma_cell_lines [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.Lng.20.AllAg.Lung_adenocarcinoma_cell_lines hg19 Histone Lung Lung adenocarcino...ma cell lines SRX1143596,SRX1143597,SRX1143598,SRX1143599 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.Lng.20.AllAg.Lung_adenocarcinoma_cell_lines.bed ...

Process safety management implementation in Pertamina - Badak LNG plant; Mise en pratique de la gestion de la securite Pertamina - usine de PT Badak

Energy Technology Data Exchange (ETDEWEB)

Amsyari, M.; Sunarmo, J. [PT Badak NGL (Indonesia)

2000-07-01

The Badak LNG Plant is located in Bontang, East Kalimantan, Indonesia, and owned by Pertamina (Indonesian Government Oil Company). The total production is about 18.00 million tones per annum of LNG. In the year 2000 the total LNG production of the Badak LNG Plant will be about 21.64 million tones per annum, produced from eight LNG Trains. These company milestones and other achievements are based on the Pertamina initiatives in 1977 to build two LNG Trains in Bontang. In order to maintain continuous supply of LNG to the buyers, Badak LNG Plant Management has established The Company Philosophy i.e. To Operate the Badak LNG Plant Safely, Reliably and Efficiently. Process Safety Management has been implemented in the Badak LNG Plant to fulfill The Company Policy. Management of Change, one of the Process Safety Management elements, is considered the most important element in the support of the Plant operations of the Badak LNG Plant. This paper will explore the Badak LNG Plant Experiences to apply Management Of Change starting with the initial implementation. The Badak LNG Plant Management Of Change is divided into three stages i.e. Evaluation/Study Stage, Safety Review Stage and Documentation Stage. These three stages are combined into a single component referred to as the 'Project Flow Of Work'. In order to ensure that the Safety Review Stage can be conducted in a timely manner to support the 'Project Flow of Work', the Badak LNG Plant has developed and established a 'Hazops Committee'. This group consists of multi disciplined members and is chaired by the Process Engineering Section Head. A high commitment and consistent application of Management Of Change has helped the Badak LNG Plant succeed to fulfill the Company Philosophy especially related to Safety. Up to the end of July 1999, the Badak LNG Plant had achieved 50 Million Working Hours without a lost time accident. (authors)

Process safety management implementation in Pertamina - Badak LNG plant; Mise en pratique de la gestion de la securite Pertamina - usine de PT Badak

Energy Technology Data Exchange (ETDEWEB)

Amsyari, M; Sunarmo, J [PT Badak NGL (Indonesia)

2000-07-01

The Badak LNG Plant is located in Bontang, East Kalimantan, Indonesia, and owned by Pertamina (Indonesian Government Oil Company). The total production is about 18.00 million tones per annum of LNG. In the year 2000 the total LNG production of the Badak LNG Plant will be about 21.64 million tones per annum, produced from eight LNG Trains. These company milestones and other achievements are based on the Pertamina initiatives in 1977 to build two LNG Trains in Bontang. In order to maintain continuous supply of LNG to the buyers, Badak LNG Plant Management has established The Company Philosophy i.e. To Operate the Badak LNG Plant Safely, Reliably and Efficiently. Process Safety Management has been implemented in the Badak LNG Plant to fulfill The Company Policy. Management of Change, one of the Process Safety Management elements, is considered the most important element in the support of the Plant operations of the Badak LNG Plant. This paper will explore the Badak LNG Plant Experiences to apply Management Of Change starting with the initial implementation. The Badak LNG Plant Management Of Change is divided into three stages i.e. Evaluation/Study Stage, Safety Review Stage and Documentation Stage. These three stages are combined into a single component referred to as the 'Project Flow Of Work'. In order to ensure that the Safety Review Stage can be conducted in a timely manner to support the 'Project Flow of Work', the Badak LNG Plant has developed and established a 'Hazops Committee'. This group consists of multi disciplined members and is chaired by the Process Engineering Section Head. A high commitment and consistent application of Management Of Change has helped the Badak LNG Plant succeed to fulfill the Company Philosophy especially related to Safety. Up to the end of July 1999, the Badak LNG Plant had achieved 50 Million Working Hours without a lost time accident. (authors)

Casting a cold eye on LNG : the real possibilities and pitfalls for Atlantic Canada

International Nuclear Information System (INIS)

Weissenberger, A.T.; Crowley, B.L.

2006-01-01

The factors that drive the economic viability of a proposed liquefied natural gas (LNG) project in Atlantic Canada were discussed along with its impact on the region's energy future. The proximity of Atlantic Canada to the high-priced US northeast energy market and the accessibility of its ports gives the region a competitive advantage to become North America's first mover for LNG. Three proposed LNG projects in Atlantic Canada are located in industrial areas where local support is strong. The projects represent more than $5 billion in direct investment. These include the Irving Oil/Repsol terminal at Canaport in Saint John, New Brunswick; Anadarko's terminal at Bear Head, Nova Scotia and Keltic Petrochemical's proposed integrated petrochemical plant and LNG terminal at Goldboro, Nova Scotia. The market issues that must be addressed prior to any LNG project include long-term supply contracts, market response and pipeline capacity. The issues will ultimately be decided by markets and regulatory processes. This document emphasized the significance of the first-mover advantage, and noted that those who gain an early market share will profit from higher prices, access to better customers and potential economies of scale from a well-established presence. Short-term benefits include the jobs created by the construction and operation of a terminal, and the municipal tax revenues it would generate. Long-term benefits include transportation cost savings from pipeline expansion; access to additional gas supplies; and gains for regional prosperity. The final factors in support of LNG projects in Atlantic Canada include the need to strengthen trade ties with the New England States and access to the US gas markets. refs., tabs., figs

Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice.

Directory of Open Access Journals (Sweden)

Diego C Reino

Full Text Available Injurious non-microbial factors released from the stressed gut during shocked states contribute to the development of acute lung injury (ALI and multiple organ dysfunction syndrome (MODS. Since Toll-like receptors (TLR act as sensors of tissue injury as well as microbial invasion and TLR4 signaling occurs in both sepsis and noninfectious models of ischemia/reperfusion (I/R injury, we hypothesized that factors in the intestinal mesenteric lymph after trauma hemorrhagic shock (T/HS mediate gut-induced lung injury via TLR4 activation.The concept that factors in T/HS lymph exiting the gut recreates ALI is evidenced by our findings that the infusion of porcine lymph, collected from animals subjected to global T/HS injury, into naïve wildtype (WT mice induced lung injury. Using C3H/HeJ mice that harbor a TLR4 mutation, we found that TLR4 activation was necessary for the development of T/HS porcine lymph-induced lung injury as determined by Evan's blue dye (EBD lung permeability and myeloperoxidase (MPO levels as well as the induction of the injurious pulmonary iNOS response. TRIF and Myd88 deficiency fully and partially attenuated T/HS lymph-induced increases in lung permeability respectively. Additional studies in TLR2 deficient mice showed that TLR2 activation was not involved in the pathology of T/HS lymph-induced lung injury. Lastly, the lymph samples were devoid of bacteria, endotoxin and bacterial DNA and passage of lymph through an endotoxin removal column did not abrogate the ability of T/HS lymph to cause lung injury in naïve mice.Our findings suggest that non-microbial factors in the intestinal mesenteric lymph after T/HS are capable of recreating T/HS-induced lung injury via TLR4 activation.

Using of polyamide in construction of supporting blocks of cryogenic tanks on example of LNG container

OpenAIRE

E. Lisowski; W. Czyżycki; K. Łazarczyk

2010-01-01

Interest in using of cryogenic gases is increasing recently. It particularly applies to LNG (Liquefied Natural Gas), which is relatively inexpensive and environmental friendly. In the liquefied form this gas is highly compressed. One cubic meter of liquefied LNG can be expanded to 660 cubic meters of normal usable gas. At the atmospheric pressure, the liquefaction temperature of LNG is under minus 160 Celsius degrees. Therefore, there is a necessity to store it in a cryogenic tank. A system o...

Investments in the LNG Value Chain: A Multistage Stochastic Optimization Model focusing on Floating Liquefaction Units

OpenAIRE

Røstad, Lars Dybsjord; Erichsen, Jeanette Christine

2012-01-01

In this thesis, we have developed a strategic optimization model of investments in infrastructure in the LNG value chain. The focus is on floating LNG production units: when they are a viable solution and what value they add to the LNG value chain. First a deterministic model is presented with focus on describing the value chain, before it is expanded to a multistage stochastic model with uncertain field sizes and gas prices. The objective is to maximize expected discounted profits through op...

Calculation models for prediction of Liquefied Natural Gas (LNG) ageing during ship transportation

Energy Technology Data Exchange (ETDEWEB)

Miana, Mario; Hoyo, Rafael del; Rodrigalvarez, Vega; Valdes, Jose Ramon [Instituto Tecnologico de Aragon, Area de Investigacion, Desarrollo y Servicios Tecnologicos, Maria de Luna 7, 50018 Zaragoza (Spain); Llorens, Raul [ENAGAS SA, Direccion de Ingenieria y Tecnologia del Gas, Autovia A - 2, km. 306.4, 50012 Zaragoza (Spain)

2010-05-15

A group of European gas transportation companies within the European Gas Research Group launched in 2007 the 'MOLAS' Project to provide a software program for the analysis of the Liquefied Natural Gas (LNG) ageing process during ship transportation. This program contains two different modeling approaches: a physical algorithm and an 'intelligent' model. Both models are fed with the same input data, which is composed of the ship characteristics (BOR and capacity), voyage duration, LNG composition, temperature, pressure, and volume occupied by liquid phase at the port of origin, together with pressure at the port of destination. The results obtained are the LNG composition, temperature and liquid volume at the port of destination. Furthermore, the physical model obtains the evolution over time of such variables en route as it is based on unsteady mass balances over the system, while the i-model applies neural networks to obtain regression coefficients from historical data composed only of origin and destination measurements. This paper describes both models and validates them from previous published models and experimental data measured in ENAGAS LNG regasification plants. (author)

A combined cycle utilizing LNG and low-temperature solar energy

International Nuclear Information System (INIS)

Rao, Wen-Ji; Zhao, Liang-Ju; Liu, Chao; Zhang, Mo-Geng

2013-01-01

This paper has proposed a combined cycle, in which low-temperature solar energy and cold energy of liquefied natural gas (LNG) can be effectively utilized together. Comparative analysis based on a same net work output between the proposed combined cycle and separated solar ORC and LNG vapor system has been done. The results show that, for the combined cycle, a decrease of nearly 82.2% on the area of solar collector is obtained and the area of heat exchanger decreases by 31.7%. Moreover, exergy efficiency is higher than both two separated systems. This work has also dealt with the thermodynamic analyses for the proposed cycle. The results show that R143a followed by propane and propene emerges as most suitable fluid. Moreover, with a regenerator added in the cycle, performance improvement is obtained for the reduction on area of solar collector and increase on system efficiency and exergy efficiency. -- Highlights: • A combined cycle utilizing low-temperature solar energy and LNG together is proposed. • Five objection functions are used to decide the best working fluids. • Cycle with a regenerator has good performance

Third party access to LNG terminals. GIIGNL - Commercial Study Group Topic 8

International Nuclear Information System (INIS)

2012-11-01

This report has been elaborated in the context of the GIIGNL Commercial Study Group (CSG) activities, which include as one of its topics the 'Third Party Access to LNG terminals' (Topic 8), led by Enagas. The 2010 edition is the third update to the report presented during the meeting of the GIIGNL Commercial Study Group in Tokyo, Japan, in September 2007. - Section 1 includes a review of the regulatory TPA regimes of LNG terminals in operation in Europe. The existing regime in each country, or for each terminal, is reviewed following a number of subsections. Each subsection follows the same structure in order to better understand the different arrangements and facilitate comparisons. - Section 2 shows data on effective usage and TPA access to each LNG terminal since 2000. Three main data are shown where available: number of cargoes delivered, volumes unloaded / sent-out, and the part of these cargoes/volumes that correspond to third parties. - Section 3 includes a tariff comparison for TPA to LNG terminals in Europe, taking into account the terms and conditions in force as of July 2010. - A description of the regulatory situation in the US in Sections 4. Access conditions to the three terminals under regulated TPA have been included for the first time: Lake Charles, Cove Point and Elba Island. An overview of Mexico and Canada is also reported. - An overview of the regulatory situation in Japan is provided in Section 5. The information required for the elaboration of this report has been collected from official web sites (LNG operators, regulatory authorities and industry associations), public reports and industry and statistical data Enagas deems to be reliable. For the adoption of certain hypothesis in Section 3 Enagas has also relied in information directly provided by operators

Studi Awal Desain LNG (Liquefied Natural Gas Plant Dari Coal Bed Methane (CBM Dengan Kapasitas Feed 40 MMSCFD

Directory of Open Access Journals (Sweden)

Muhammad Fahmi

2013-09-01

Full Text Available Dalam penelitian ini telah dilakukan perancangan Liquefied Natural Gas (LNG Plant dari CBM degan kapasitas feed 40 MMSCFD dan waktu operasi 24 jam/hari dan 330 hari/tahun. Perancangan LNG plant dari CBM ini bertujuan untuk membantu usaha Negara dalam melakukan diversifikasi energi untuk mengatasi krisis energi. Salah satu contoh diversifikasi energi adalah mengganti bahan bakar pembangkit listrik High Speed Diesel (HSD menjadi LNG yang harganya relative lebih murah. Penelitian ini didasarkan pada simulasi dengan Aspen HYSYS, dimana terdapat batasan penelitian yakni gas alam yang dicairkan dengan cara didinginkan pada temperatur sekitar -161.3oC dan pada tekanan 1.06 bar. Tujuan pabrik LNG ini adalah Provinsi Bali hal ini dikarenakan elektrifikasi daerah tersebut cukup rendah. Dengan konsumsi minyak HSD yang tinggi tetapi elektrifikasi yang rendah maka diperlukan sumber energi alternatif untuk meningkatkan daya yang dihasilkan dan area distribusi sehingga tingkat elektrifikasi akan menjadi lebih tinggi. Pabrik LNG ini didirikan di Muara Enim, Sumatera Selatan pada tahun 2016. Penentuan lokasi pabrik berorientasi pada ketersediaan sumber bahan baku CBM. Menurut data DITJEN MIGAS Muara enim memiliki potensi CBM sebesar 0.5 TCF. Potensi sebesar ini dapat digunakan selama 60 tahun dengan kapasitas feed LNG plant sebesar 40 MMSCFD Proses pembuatan LNG dari gas alam ini menggunakan Proses On-Shore LNG menggunakan beberapa rangkaian proses yaitu : Unit Penghilang CO2 dan H2S : menggunakan Amine Cycle, Unit Dehidrasi : menggunakan molecular sieve, Unit Refrigeran dan Pencairan : menggunakan MCR Coldbox Sumber dana investasi berasal dari modal sendiri sebesar 20 % biaya investasi dan pinjaman jangka pendek sebesar 80 % biaya investasi dengan bunga sebesar 12 % per tahun. Dari analisa perhitungan ekonomi didapat hasil-hasil sebagai berikut : Investasi : 163,557 MUSD, Internal Rate of Return : 25.66 %, POT : 3.26 tahun, BEP : 58.86 %, NPV 10 year   :120

Blast-induced traumatic brain injury: a new trend of blast injury research.

Science.gov (United States)

Zhao, Yan; Wang, Zheng-Guo

2015-01-01

Blast injury has become the major life- and function-threatening injuries in recent warfares. There is increased research interest in the mental disorders caused by blast-induced traumatic brain injury (bTBI), which has been proved as one of the "signature wounds" in modern battlefield. We reviewed the recent progresses in bTBI-related researches and concluded that the new era of blast injury research has shifted from the traditional physical impairments to cognitive dysfunctional/mental disorders that are proved to be more related to the outcome of combat casualty care.

Guidance on risk analysis and safety implications of a large liquefied natural gas (LNG) spill over water.

Energy Technology Data Exchange (ETDEWEB)

Wellman, Gerald William; Melof, Brian Matthew; Luketa-Hanlin, Anay Josephine; Hightower, Marion Michael; Covan, John Morgan; Gritzo, Louis Alan; Irwin, Michael James; Kaneshige, Michael Jiro; Morrow, Charles W.

2004-12-01

While recognized standards exist for the systematic safety analysis of potential spills or releases from LNG (Liquefied Natural Gas) storage terminals and facilities on land, no equivalent set of standards or guidance exists for the evaluation of the safety or consequences from LNG spills over water. Heightened security awareness and energy surety issues have increased industry's and the public's attention to these activities. The report reviews several existing studies of LNG spills with respect to their assumptions, inputs, models, and experimental data. Based on this review and further analysis, the report provides guidance on the appropriateness of models, assumptions, and risk management to address public safety and property relative to a potential LNG spill over water.

Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.

Directory of Open Access Journals (Sweden)

Heather D Jones

Full Text Available Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-induced lung injury and exacerbates the injury when given exogenously. Nicotinamide (vitamin B3 directly inhibits downstream pathways activated by Nicotinamide phosphoribosyltransferase and is protective in other models of acute lung injury.We administered nicotinamide i.p. to mice undergoing mechanical ventilation with high tidal volumes to study the effects of nicotinamide on ventilator-induced lung injury. Measures of injury included oxygen saturations and bronchoalveolar lavage neutrophil counts, protein, and cytokine levels. We also measured expression of nicotinamide phosophoribosyltransferase, and its downstream effectors Sirt1 and Cebpa, Cebpb, Cebpe. We assessed the effect of nicotinamide on the production of nitric oxide during ventilator-induced lung injury. We also studied the effects of ventilator-induced lung injury in mice deficient in C/EBPε.Nicotinamide treatment significantly inhibited neutrophil infiltration into the lungs during ventilator-induced lung injury, but did not affect protein leakage or cytokine production. Surprisingly, mice treated with nicotinamide developed significantly worse hypoxemia during mechanical ventilation. This effect was not linked to increases in nitric oxide production or alterations in expression of Nicotinamide phosphoribosyl transferase, Sirt1, or Cebpa and Cebpb. Cebpe mRNA levels were decreased with either nicotinamide treatment or mechanical ventilation, but mice lacking C/EBPε developed the same degree of hypoxemia and ventilator-induced lung injury as wild-type mice.Nicotinamide treatment during VILI inhibits neutrophil infiltration of the lungs consistent with a strong anti-inflammatory effect, but paradoxically also leads to the

Thermodynamic analysis of a novel power plant with LNG (liquefied natural gas) cold exergy exploitation and CO_2 capture

International Nuclear Information System (INIS)

Romero Gómez, Manuel; Romero Gómez, Javier; López-González, Luis M.; López-Ochoa, Luis M.

2016-01-01

The LNG (liquefied natural gas) regasification process is a source of cold exergy that is suitable to be recovered to improve the efficiency of thermal power plants. In this paper, an innovative power plant with LNG (liquefied natural gas) exergy utilisation and the capture of CO_2 proceeding from the flue gases is presented. It is characterised by the recovery of LNG cold exergy in a closed Brayton cycle and through direct expansion in an expander coupled to an electrical generator. Moreover, this novel power plant configuration allows CO_2 capture, through an oxy-fuel combustion system and a Rankine cycle that operates with the flue gases themselves and in quasi-critical conditions. The greatest advantage of this plant is that all the recoverable LNG exergy is used to increase the efficiency of the CBC (closed Brayton cycle) and in direct expansion whereas, in other power cycles found in literature that associate LNG regasification and CO_2 capture, part of the LNG exergy is used for condensing flue gas CO_2 for its subsequent capture. As a result, a high efficiency power plant is achieved, exceeding 65%, with almost zero greenhouse gas emissions. - Highlights: • LNG cold exergy can be recovered to improve the efficiency of power plants. • High efficiency power plant with almost zero greenhouse gas emissions. • CO_2 capture through an oxy-fuel combustion system and a Rankine cycle. • Sensitivity analysis of key parameters to evaluate the effect on the efficiency. • The exergy available in the LNG represents 34.79% of the fuel exergy.

Drug-induced liver injury due to antibiotics.

Science.gov (United States)

Björnsson, Einar S

Drug-induced liver injury (DILI) is an important differential diagnosis in patients with abnormal liver tests and normal hepatobiliary imaging. Of all known liver diseases, the diagnosis of DILI is probably one of the most difficult one to be established. In all major studies on DILI, antibiotics are the most common type of drugs that have been reported. The clinical phenotype of different types of antibiotics associated with liver injury is highly variable. Some widely used antibiotics such as amoxicillin-clavulanate have been shown to have a delayed onset on liver injury and recently cefazolin has been found to lead to liver injury 1-3 weeks after exposure of a single infusion. The other extreme is the nature of nitrofurantoin-induced liver injury, which can occur after a few years of treatment and lead to acute liver failure (ALF) or autoimmune-like reaction. Most patients with liver injury associated with use of antibiotics have a favorable prognosis. However, patients with jaundice have approximately 10% risk of death from liver failure and/or require liver transplantation. In rare instances, the hepatoxicity can lead to chronic injury and vanishing bile duct syndrome. Given, sometimes very severe consequences of the adverse liver reactions, it cannot be over emphasized that the indication for the different antibiotics should be evidence-based and symptoms and signs of liver injury from the drugs should lead to prompt cessation of therapy.

Designing Optimal LNG Station Network for U.S. Heavy-Duty Freight Trucks using Temporally and Spatially Explicit Supply Chain Optimization

Science.gov (United States)

Lee, Allen

The recent natural gas boom has opened much discussion about the potential of natural gas and specifically Liquefied Natural Gas (LNG) in the United States transportation sector. The switch from diesel to natural gas vehicles would reduce foreign dependence on oil, spur domestic economic growth, and potentially reduce greenhouse gas emissions. LNG provides the most potential for the medium to heavy-duty vehicle market partially due to unstable oil prices and stagnant natural gas prices. As long as the abundance of unconventional gas in the United States remains cheap, fuel switching to natural gas could provide significant cost savings for long haul freight industry. Amid a growing LNG station network and ever increasing demand for freight movement, LNG heavy-duty truck sales are less than anticipated and the industry as a whole is less economic than expected. In spite of much existing and mature natural gas infrastructure, the supply chain for LNG is different and requires explicit and careful planning. This thesis proposes research to explore the claim that the largest obstacle to widespread LNG market penetration is sub-optimal infrastructure planning. No other study we are aware of has explicitly explored the LNG transportation fuel supply chain for heavy-duty freight trucks. This thesis presents a novel methodology that links a network infrastructure optimization model (represents supply side) with a vehicle stock and economic payback model (represents demand side). The model characterizes both a temporal and spatial optimization model of future LNG transportation fuel supply chains in the United States. The principal research goal is to assess the economic feasibility of the current LNG transportation fuel industry and to determine an optimal pathway to achieve ubiquitous commercialization of LNG vehicles in the heavy-duty transport sector. The results indicate that LNG is not economic as a heavy-duty truck fuel until 2030 under current market conditions

Theoretical and computational analyses of LNG evaporator

Science.gov (United States)

Chidambaram, Palani Kumar; Jo, Yang Myung; Kim, Heuy Dong

2017-04-01

Theoretical and numerical analysis on the fluid flow and heat transfer inside a LNG evaporator is conducted in this work. Methane is used instead of LNG as the operating fluid. This is because; methane constitutes over 80% of natural gas. The analytical calculations are performed using simple mass and energy balance equations. The analytical calculations are made to assess the pressure and temperature variations in the steam tube. Multiphase numerical simulations are performed by solving the governing equations (basic flow equations of continuity, momentum and energy equations) in a portion of the evaporator domain consisting of a single steam pipe. The flow equations are solved along with equations of species transport. Multiphase modeling is incorporated using VOF method. Liquid methane is the primary phase. It vaporizes into the secondary phase gaseous methane. Steam is another secondary phase which flows through the heating coils. Turbulence is modeled by a two equation turbulence model. Both the theoretical and numerical predictions are seen to match well with each other. Further parametric studies are planned based on the current research.

Primary blast-induced traumatic brain injury: lessons from lithotripsy

Science.gov (United States)

Nakagawa, A.; Ohtani, K.; Armonda, R.; Tomita, H.; Sakuma, A.; Mugikura, S.; Takayama, K.; Kushimoto, S.; Tominaga, T.

2017-11-01

Traumatic injury caused by explosive or blast events is traditionally divided into four mechanisms: primary, secondary, tertiary, and quaternary blast injury. The mechanisms of blast-induced traumatic brain injury (bTBI) are biomechanically distinct and can be modeled in both in vivo and in vitro systems. The primary bTBI injury mechanism is associated with the response of brain tissue to the initial blast wave. Among the four mechanisms of bTBI, there is a remarkable lack of information regarding the mechanism of primary bTBI. On the other hand, 30 years of research on the medical application of shock waves (SWs) has given us insight into the mechanisms of tissue and cellular damage in bTBI, including both air-mediated and underwater SW sources. From a basic physics perspective, the typical blast wave consists of a lead SW followed by shock-accelerated flow. The resultant tissue injury includes several features observed in primary bTBI, such as hemorrhage, edema, pseudo-aneurysm formation, vasoconstriction, and induction of apoptosis. These are well-described pathological findings within the SW literature. Acoustic impedance mismatch, penetration of tissue by shock/bubble interaction, geometry of the skull, shear stress, tensile stress, and subsequent cavitation formation are all important factors in determining the extent of SW-induced tissue and cellular injury. In addition, neuropsychiatric aspects of blast events need to be taken into account, as evidenced by reports of comorbidity and of some similar symptoms between physical injury resulting in bTBI and the psychiatric sequelae of post-traumatic stress. Research into blast injury biophysics is important to elucidate specific pathophysiologic mechanisms of blast injury, which enable accurate differential diagnosis, as well as development of effective treatments. Herein we describe the requirements for an adequate experimental setup when investigating blast-induced tissue and cellular injury; review SW physics

Techno-economic feasibility study of a system for the transfer of refrigeration capacity from LNG regasification plants to industrial assets

NARCIS (Netherlands)

Pineda Quijano, Diego; Infante Ferreira, C.A.; Duivenvoorden, Wil; Mieog, Juriaan; van der Noortgaete, Tom; van Velpen, Bart

2017-01-01

The recovery of cold energy during the regasification of Liquefied Natural Gas (LNG) has gained attention in recent years due to the fast growth of the LNG trade market and the increasing importance that governments are giving to energy efficiency and sustainability. Near 200 kWh/ton of LNG are

LNG businesses evaluation: strategic positioning; Avaliacao de negocios de GNL: posicionamento estrategico

Energy Technology Data Exchange (ETDEWEB)

Toste, Ana Cristina Leitao Goncalves; Frozza, Eduardo [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

2008-07-01

Given the global development of the LNG industry and the changes it has suffered along the recent years, companies must evaluate how they should better position themselves towards this business, in order to optimize resources and maximize gains. The present work discusses three fictitious cases, in an effort to delineate and understand the several issues that impact a business decision in the LNG industry. In each case, business evaluation is performed taking into consideration project economics, as well as risk and strategy issues. (author)

Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

Energy Technology Data Exchange (ETDEWEB)

Yoshikawa, Yukitaka; Miyashita, Taishi; Higuchi, Satonori [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920‐1192 (Japan); Tsuneyama, Koichi [Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Sugitani, Toyama 930‐0194 (Japan); Endo, Shinya [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920‐1192 (Japan); Tsukui, Tohru [Research Center for Genomic Medicine, Saitama Medical University, Yamane, Hidaka 350‐1241 (Japan); Toyoda, Yasuyuki; Fukami, Tatsuki; Nakajima, Miki [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920‐1192 (Japan); Yokoi, Tsuyoshi, E-mail: tyokoi@p.kanazawa-u.ac.jp [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920‐1192 (Japan)

2012-10-01

Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia–reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury. The present study investigated the effects of an ERα agonist, selective ER modulators (SERMs) and an ER antagonist on drug-induced and chemical-induced liver injuries caused by acetaminophen, bromobenzene, diclofenac, and thioacetamide (TA). We observed hepatoprotective effects of EE2, tamoxifen (TAM) and raloxifene pretreatment in female mice that were exposed to a variety of hepatotoxic compounds. In contrast, the ER antagonist did not show any hepatoprotective effects. DNA microarray analyses suggested that monocyte to macrophage differentiation-associated 2 (Mmd2) protein, which has an unknown function, is commonly increased by TAM and RAL pretreatment, but not by pretreatment with the ER antagonist. In ERα-knockout mice, the hepatoprotective effects of TAM and the increased expression of Mmd2 mRNA were not observed in TA-induced liver injury. To investigate the function of Mmd2, the expression level of Mmd2 mRNA was significantly knocked down to approximately 30% in mice by injection of siRNA for Mmd2 (siMmd2). Mmd2 knockdown resulted in a reduction of the protective effects of TAM on TA-induced liver injury in mice. This is the first report of the involvement of ERα in drug-induced or chemical-induced liver injury. Upregulation of Mmd2 protein in the liver was suggested as the mechanism of the hepatoprotective effects of EE2 and SERMs. -- Highlights: ► Liver injury induced by drugs or chemicals was investigated in mice. ► Liver injury was suppressed by pretreatment with tamoxifen in female mice. ► Mmd2, whose function was unknown, could be a candidate gene for liver protection. ► Tamoxifen up-regulated Mmd2 mRNA expression

Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

International Nuclear Information System (INIS)

Yoshikawa, Yukitaka; Miyashita, Taishi; Higuchi, Satonori; Tsuneyama, Koichi; Endo, Shinya; Tsukui, Tohru; Toyoda, Yasuyuki; Fukami, Tatsuki; Nakajima, Miki; Yokoi, Tsuyoshi

2012-01-01

Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia–reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury. The present study investigated the effects of an ERα agonist, selective ER modulators (SERMs) and an ER antagonist on drug-induced and chemical-induced liver injuries caused by acetaminophen, bromobenzene, diclofenac, and thioacetamide (TA). We observed hepatoprotective effects of EE2, tamoxifen (TAM) and raloxifene pretreatment in female mice that were exposed to a variety of hepatotoxic compounds. In contrast, the ER antagonist did not show any hepatoprotective effects. DNA microarray analyses suggested that monocyte to macrophage differentiation-associated 2 (Mmd2) protein, which has an unknown function, is commonly increased by TAM and RAL pretreatment, but not by pretreatment with the ER antagonist. In ERα-knockout mice, the hepatoprotective effects of TAM and the increased expression of Mmd2 mRNA were not observed in TA-induced liver injury. To investigate the function of Mmd2, the expression level of Mmd2 mRNA was significantly knocked down to approximately 30% in mice by injection of siRNA for Mmd2 (siMmd2). Mmd2 knockdown resulted in a reduction of the protective effects of TAM on TA-induced liver injury in mice. This is the first report of the involvement of ERα in drug-induced or chemical-induced liver injury. Upregulation of Mmd2 protein in the liver was suggested as the mechanism of the hepatoprotective effects of EE2 and SERMs. -- Highlights: ► Liver injury induced by drugs or chemicals was investigated in mice. ► Liver injury was suppressed by pretreatment with tamoxifen in female mice. ► Mmd2, whose function was unknown, could be a candidate gene for liver protection. ► Tamoxifen up-regulated Mmd2 mRNA expression

Histopathology of cryoballoon ablation-induced phrenic nerve injury.

Science.gov (United States)

Andrade, Jason G; Dubuc, Marc; Ferreira, Jose; Guerra, Peter G; Landry, Evelyn; Coulombe, Nicolas; Rivard, Lena; Macle, Laurent; Thibault, Bernard; Talajic, Mario; Roy, Denis; Khairy, Paul

2014-02-01

Hemi-diaphragmatic paralysis is the most common complication associated with cryoballoon ablation for atrial fibrillation, yet the histopathology of phrenic nerve injury has not been well described. A preclinical randomized study was conducted to characterize the histopathology of phrenic nerve injury induced by cryoballoon ablation and assess the potential for electromyographic (EMG) monitoring to limit phrenic nerve damage. Thirty-two dogs underwent cryoballoon ablation of the right superior pulmonary vein with the objective of inducing phrenic nerve injury. Animals were randomized 1:1 to standard monitoring (i.e., interruption of ablation upon reduction in diaphragmatic motion) versus EMG guidance (i.e., cessation of ablation upon a 30% reduction in the diaphragmatic compound motor action potential [CMAP] amplitude). The acute procedural endpoint was achieved in all dogs. Phrenic nerve injury was characterized by Wallerian degeneration, with subperineural injury to large myelinated axons and evidence of axonal regeneration. The degree of phrenic nerve injury paralleled the reduction in CMAP amplitude (P = 0.007). Animals randomized to EMG guidance had a lower incidence of acute hemi-diaphragmatic paralysis (50% vs 100%; P = 0.001), persistent paralysis at 30 days (21% vs 75%; multivariate odds ratio 0.12, 95% confidence interval [0.02, 0.69], P = 0.017), and a lesser severity of histologic injury (P = 0.001). Mature pulmonary vein ablation lesion characteristics, including circumferentiality and transmurality, were similar in both groups. Phrenic nerve injury induced by cryoballoon ablation is axonal in nature and characterized by Wallerian degeneration, with potential for recovery. An EMG-guided approach is superior to standard monitoring in limiting phrenic nerve damage. © 2013 Wiley Periodicals, Inc.

Evaluasi dan Analisis Dampak Program Corporate Social Responsibility Badak LNG

Directory of Open Access Journals (Sweden)

Hanes Utama

2017-08-01

Full Text Available Program CSR Badak LNG telah melibatkan masyarakat dalam proses perencanaan, pelaksanaan, sampai pada proses monitoring dan evaluasi. Hal ini tentu berdampak pada peningkatan kualitas program serta meningkatkan peran partisipasi masyarakat sebagai kelompok sasaran penerima program CSR. Tujuan dari penelitian ini adalah mengukur tingkat kepuasan masyarakat terhadap program CSR yang telah dijalankan dan mengevaluasi dampak program CSR yang telah dilakukan. Adapun metode yang digunakan adalah  melalui pendekatan kajian input, output, outcome dan impact melalui analisis Indeks Kepuasan Masyarakat, Importance Performance Analysis, dan Compass Sustainability Analysis. Hasil penelitian menunjukkan secara keseluruhan kepuasan masyarakat terhadap pelayanan program CSR Badak LNG menunjukkan parameter sangat baik. Tingkat kesesuaian antara kepuasan kinerja dengan tingkat kepentingan masyarakat masuk dalam kategori sangat baik. Indikator kejelasan petugas pendamping,  tanggung jawab petugas pendamping, kemampuan petugas pendamping,  kesopanan petugas pendamping, dan kepastian biaya pelayanan adalah indikator yang memiliki harapan tinggi dari masyarakat penerima manfaat, dan perusahaan memiliki kinerja yang sangat baik dalam hal tersebut. Dampak positif yang diterima dari  kegiatan CSR pada dimensi nature, wellbeing, economy, social di Kota Bontang sangat tinggi, di antaranya terjadinya peningkatan kualitas lingkungan, pemanfaatan potensi alam, peningkatan pendapatan masyarakat, pengentasan kemiskinan, peningkatan kemandirian UMKM, semakin dikenalnya kebudayaan masyarakat, dan tingginya tingkat kepuasan masyarakat terhadap kegiatan-kegiatan CSR Badak LNG. The CSR program from Badak LNG has been involving the society in the planning, implementation, monitoring and evaluation process. It has an impact to the improvement quality program and increase peoples participation as a CSR awardee. This research aims to measure the peoples satisfactory towards CSR

Bowel injuries secondary to induced abortion: a dilemma

International Nuclear Information System (INIS)

Rehman, A.; Fatima, S.; Soomro, N.

2006-01-01

To study the pattern of bowel injuries incurred by induced abortion, and the morbidity and mortality associated with them. All patients with bowel injuries due to induced abortion. Detailed data of all the patients was collected and analyzed. A total of 22 patients, mostly young with an average age of 26.86 years, presented with bowel injuries following induced abortion. Severe hemorrhage occurred in 8(36.4%) patients while 11(50%) had ileal perforation; 9(40.9%) underwent primary repair and 2(9.1%) ileostomy formation. Two (9.1%) patients with jejunal perforation had primary repair, whereas two with both jejunal and ileal perforations underwent resections with anastomosis in one and ileostomy in another. Seven (31.8%) with large gut involvement had colostomy formation. Septicemia and wound infection occurred in 7(31.8%) patients each, faecal fistula and abdominal wound dehiscence in 3(13.6%), and pelvic abscess in 1(4.6%) patient. The total mortality in this series was 6(27.3%) patients. Iatrogenic injuries during induced abortion, most commonly caused by quacks, can be minimized substantially if the procedure is performed by qualified medical personnel in proper health care facilities. There is a need for radical overhauling of the mind set in our society together with legislation. (author)

Is a 125,000 M3 class ship always an optimum for LNG carriers 7

International Nuclear Information System (INIS)

Grill, A.

1992-01-01

When making the inventory of LNG carriers built up to the present day, one can see that ships of 125 to 130,000 m 3 may be considered as a real standard. An increase of ship's size, together with a reduction of the number of ships required on a given trade, must lead to a reduction of transportation cost. It must also be possible to obtain a better correlation between available energy during voyage and propulsion needs by adjusting boil-off rate and adapting the tanks insulation coefficient. The presentation shows the possibility to significantly reduce LNG transportation cost by an optimization of the size for future ships. The study is based on a certain number of typical trades being able to be met when taking into account future foreseeable needs for LNG. The influence of parameters such as type of containment system and number of tanks, type of propulsion, influence of size restrictions, ability to deliver a given amount of LNG per year even in case of one ship temporary out of order is also considered

Acute liver injury induced by weight-loss herbal supplements.

Science.gov (United States)

Chen, Gary C; Ramanathan, Vivek S; Law, David; Funchain, Pauline; Chen, George C; French, Samuel; Shlopov, Boris; Eysselein, Viktor; Chung, David; Reicher, Sonya; Pham, Binh V

2010-11-27

We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients demonstrated findings consistent with drug-induced acute liver injury. To our knowledge, we are the first institute to report acute liver injury from both of these two types of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supplements for the purpose of weight loss.

Using of polyamide in construction of supporting blocks of cryogenic tanks on example of LNG container

Directory of Open Access Journals (Sweden)

E. Lisowski

2010-07-01

Full Text Available Interest in using of cryogenic gases is increasing recently. It particularly applies to LNG (Liquefied Natural Gas, which is relatively inexpensive and environmental friendly. In the liquefied form this gas is highly compressed. One cubic meter of liquefied LNG can be expanded to 660 cubic meters of normal usable gas. At the atmospheric pressure, the liquefaction temperature of LNG is under minus 160 Celsius degrees. Therefore, there is a necessity to store it in a cryogenic tank. A system of reloading port terminals is built in several UE countries, as Spain, Italy. The LNG is delivered to these terminals using the adequately equipped ships. However, there are significant problems with delivering LNG to recipients not connected to the gas network directly. Delivering of liquefied LNG to recipients using the road or rail transport is one of the simplest solutions of this problem. This kind of transport is possible only with using suitable tanks with the adequate insulation and fulfilling the transport requirements. Many scientific research centers carry out investigations on high insulating-power materials. The problem to design and build universal container for road and rail transport was taken on by Cracow University of Technology together with the company Chemet from Tarnowskie Góry. Designed cryogenic tank is a two-walledconstruction with the vacuum between them. Distance between walls is provided by system of supporting blocks made of plastic. Thispaper presents problem of heat transfer between the walls through the supporting blocks. The investigations were carried out both:numerically, using the finite element method and experimentally, using the especially designed and built laboratory test stand, whichallowed to determine heat transfer coefficient.

Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation

International Nuclear Information System (INIS)

Zhang, Da-Gang; Zhang, Cheng; Wang, Jun-Xian; Wang, Bi-Wei; Wang, Hua; Zhang, Zhi-Hui; Chen, Yuan-Hua; Lu, Yan; Tao, Li; Wang, Jian-Qing; Chen, Xi; Xu, De-Xiang

2017-01-01

The farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays important roles in regulating bile acid homeostasis. The aim of the present study was to investigate the effects of obeticholic acid (OCA), a novel synthetic FXR agonist, carbon tetrachloride (CCl 4 )-induced acute liver injury. Mice were intraperitoneally injected with CCl 4 (0.15 ml/kg). In CCl 4 + OCA group, mice were orally with OCA (5 mg/kg) 48, 24 and 1 h before CCl 4 . As expected, hepatic FXR was activated by OCA. Interestingly, OCA pretreatment alleviated CCl 4 -induced elevation of serum ALT and hepatic necrosis. Moreover, OCA pretreatment inhibited CCl 4 -induced hepatocyte apoptosis. Additional experiment showed that OCA inhibits CCl 4 -induced hepatic chemokine gene Mcp-1, Mip-2 and Kc. Moreover, OCA inhibits CCl 4 -induced hepatic pro-inflammatory gene Tnf-α and Il-1β. By contrast, OCA pretreatment elevated hepatic anti-inflammatory gene Il-4. Further analysis showed that OCA pretreatment inhibited hepatic IκB phosphorylation and blocked nuclear translocation of NF-κB p65 and p50 subunits during CCl 4 -induced acute liver injury. In addition, OCA pretreatment inhibited hepatic Akt, ERK and p38 phosphorylation in CCl 4 -induced acute liver injury. These results suggest that OCA protects against CCl 4 -induced acute liver injury and inflammation. Synthetic FXR agonists may be effective antidotes for hepatic inflammation during acute liver injury. - Highlights: • OCA pretreatment activates hepatic FXR. • FXR activation protects against CCl 4 -induced acute liver injury. • FXR activation inhibits hepatocyte apoptosis during CCl 4 -induced liver injury. • FXR activation differentially regulates hepatic inflammatory genes. • Synthetic FXR agonists are effective antidotes for acute liver injury.

Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation

Energy Technology Data Exchange (ETDEWEB)

Zhang, Da-Gang [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China); Zhang, Cheng [Department of Toxicology, Anhui Medical University, Hefei 230032 (China); Wang, Jun-Xian [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China); Wang, Bi-Wei; Wang, Hua; Zhang, Zhi-Hui; Chen, Yuan-Hua [Department of Toxicology, Anhui Medical University, Hefei 230032 (China); Lu, Yan; Tao, Li; Wang, Jian-Qing [Second Affiliated Hospital, Anhui Medical University, Hefei 230601 (China); Chen, Xi [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China); Xu, De-Xiang, E-mail: xudex@126.com [Department of Toxicology, Anhui Medical University, Hefei 230032 (China)

2017-01-01

The farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays important roles in regulating bile acid homeostasis. The aim of the present study was to investigate the effects of obeticholic acid (OCA), a novel synthetic FXR agonist, carbon tetrachloride (CCl{sub 4})-induced acute liver injury. Mice were intraperitoneally injected with CCl{sub 4} (0.15 ml/kg). In CCl{sub 4} + OCA group, mice were orally with OCA (5 mg/kg) 48, 24 and 1 h before CCl{sub 4}. As expected, hepatic FXR was activated by OCA. Interestingly, OCA pretreatment alleviated CCl{sub 4}-induced elevation of serum ALT and hepatic necrosis. Moreover, OCA pretreatment inhibited CCl{sub 4}-induced hepatocyte apoptosis. Additional experiment showed that OCA inhibits CCl{sub 4}-induced hepatic chemokine gene Mcp-1, Mip-2 and Kc. Moreover, OCA inhibits CCl{sub 4}-induced hepatic pro-inflammatory gene Tnf-α and Il-1β. By contrast, OCA pretreatment elevated hepatic anti-inflammatory gene Il-4. Further analysis showed that OCA pretreatment inhibited hepatic IκB phosphorylation and blocked nuclear translocation of NF-κB p65 and p50 subunits during CCl{sub 4}-induced acute liver injury. In addition, OCA pretreatment inhibited hepatic Akt, ERK and p38 phosphorylation in CCl{sub 4}-induced acute liver injury. These results suggest that OCA protects against CCl{sub 4}-induced acute liver injury and inflammation. Synthetic FXR agonists may be effective antidotes for hepatic inflammation during acute liver injury. - Highlights: • OCA pretreatment activates hepatic FXR. • FXR activation protects against CCl{sub 4}-induced acute liver injury. • FXR activation inhibits hepatocyte apoptosis during CCl{sub 4}-induced liver injury. • FXR activation differentially regulates hepatic inflammatory genes. • Synthetic FXR agonists are effective antidotes for acute liver injury.

Full scale ambient water flow tests of a 10-inch emergency release coupling for LNG transfer

NARCIS (Netherlands)

Putte, L.J. van der; Webber, T.; Bokhorst, E. van; Revell, C.

2016-01-01

For LNG transfer in ship-to-ship and ship-to-shore configurations emergency release couplings (F.RC) in combination with loading arms and multi-composite hoses are applied In view of a demand for increasing transfer flow rates in offshore LNG applications a 10-inch ERC has been developed intended

Studi Pemilihan Sistem Supply Listrik Dengan Pendekatan Topsis Dan Desain Sistem Kelistrikan Pada Onshore Receiving Facility LNG Di Celukan Bawang, Buleleng, Bali.

Directory of Open Access Journals (Sweden)

Fadilla Indrayuni Prastyasari

2014-09-01

Full Text Available Liqueafied Natural Gas (LNG merupakan gas alam yang sudah dikonversi menjadi fase cair pada kisaran temperatur -161°C pada tekanan atmosfer. Konversi ini mereduksi volume 600 kali lebih kecil dari volume gas alam sehingga LNG lebih bernilai ekonomis untuk disimpan dan ditransportasikan. LNG dapat menjadi solusi alternatif bahan bakar bagi pembangkit listrik di Indonesia. Disamping kelebihan dari LNG, hanya sedikit gas yang dimanfaatkan langsung oleh Indonesia karena kurangnya sarana dan prasarana yang mendukung. Salah satu sarana yang dapat mendukung pendistribusian LNG adalah terminal penerima LNG dan sistem pendukungnya, kapal LNG dan dermaga, unit regasifikasi, dan yang lainnya. Studi ini bertujuan untuk memilih sistem supply listrik menggunakan metode TOPSIS dan selanjutnya mendesain sistem kelistrikan untuk ORF di Celukan Bawang – Buleleng. LNG didistribusikan menuju ke tiga pembangkit listrik yang ada di Bali: Pesanggaran, Gilimanuk, dan Pemaron. Beberapa peralatan utama dari ORF yang dipertimbangkan adalah tangki penyimpanan, kompresor BOG, recondenser, pompa kriogenik, loading arm dan lainnya, dengan total kebutuhan daya sebesar 214,6 kW. Peralatan tersebut membutuhkan sistem supply listrik yang dapat memenuhi kebutuhan listrik dari seluruh peralatan di ORF. Terdapat tiga alternatif dari sumber listrik, yaitu diesel engine generator, gas engine generator, dan supply listrik dari PLN (Perusahaan Listrik Negara. Alternatif terbaik kemudian akan dipilih menggunakan metode TOPSIS dengan dua metode pembobotan yang berbeda. Studi ini menunjukkan bahwa alternatif terbaik adalah supply listrik dari PLN. Dengan menggunakan hasil seleksi, akan dibuat desain sistem kelistrikan untuk ORF dan setiap terminal penerima LNG mini di setiap pembangkit listrik yang terdiri dari wiring diagram dan oneline diagram.

Advanced exergy-based analyses applied to a system including LNG regasification and electricity generation

Energy Technology Data Exchange (ETDEWEB)

Morosuk, Tatiana; Tsatsaronis, George; Boyano, Alicia; Gantiva, Camilo [Technische Univ. Berlin (Germany)

2012-07-01

Liquefied natural gas (LNG) will contribute more in the future than in the past to the overall energy supply in the world. The paper discusses the application of advanced exergy-based analyses to a recently developed LNG-based cogeneration system. These analyses include advanced exergetic, advanced exergoeconomic, and advanced exergoenvironmental analyses in which thermodynamic inefficiencies (exergy destruction), costs, and environmental impacts have been split into avoidable and unavoidable parts. With the aid of these analyses, the potentials for improving the thermodynamic efficiency and for reducing the overall cost and the overall environmental impact are revealed. The objectives of this paper are to demonstrate (a) the potential for generating electricity while regasifying LNG and (b) some of the capabilities associated with advanced exergy-based methods. The most important subsystems and components are identified, and suggestions for improving them are made. (orig.)

Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling.

Directory of Open Access Journals (Sweden)

Eileen M Redmond

Full Text Available To determine the efficacy of perivascular delivery of Notch 1 siRNA in preventing injury-induced arterial remodeling.Carotid artery ligation was performed to induce arterial remodeling. After 14 days, morphometric analysis confirmed increased vSMC growth and subsequent media thickening and neointimal formation. Laser capture microdissection, quantitative qRT-PCR and immunoblot analysis of medial tissue revealed a significant increase in Notch1 receptor and notch target gene, Hrt 1 and 2 expression in the injured vessels. Perivascular delivery of Notch 1 siRNA by pluronic gel inhibited the injury-induced increase in Notch 1 receptor and target gene expression when compared to scrambled siRNA controls while concomitantly reducing media thickening and neointimal formation to pre-injury, sham-operated levels. Selective Notch 1 knockdown also reversed the injury-induced inhibition of pro-apoptotic Bax expression while decreasing injury-induced anti-apoptotic Bcl-XL expression to sham-operated control levels. In parallel experiments, proliferative cyclin levels, as measured by PCNA expression, were reversed to sham-operated control levels following selective Notch 1 knockdown.These results suggest that injury-induced arterial remodeling can be successfully inhibited by localized perivascular delivery of Notch 1 siRNA.

Designing a decision support model for the LNG market

NARCIS (Netherlands)

Engelen, Steve; Dullaert, Wout

2010-01-01

As the Liquefied Natural Gas (LNG) market is supply-driven and subject to longterm contracts, both liquefaction companies and shipowners need to make strategic decisions on fleet chartering requirements. These planning decisions become ever more difficult in light of the transformations permeating

LNG (liquefied natural gas) in the Asia-Pacific region: Twenty years of trade and outlook for the future

Energy Technology Data Exchange (ETDEWEB)

Kiani, B.

1990-01-01

This report discusses the following topics: the current status of LNG trade in the Asia-Pacific region; present structure and projected demand in the Asia-Pacific region; prospective and tentative projects; and LNG contracts: stability versus flexibility.

LNG: in Asia, the demand should double by 2010

International Nuclear Information System (INIS)

Anon.

1996-01-01

In a well-documented study, ''Asia Gas Study'', published by the end of the first semester of 1996, the International Energy Agency (IEA) anticipated the doubling of the LNG demand from Asia, because of a more rapid growth of gas industry than for other energy industries. The regional gas trade should even triple by 2010. This study is the first from IEA about Asia and focusses on 6 key-countries: Brunei-Darussalam, Taiwan, Indonesia, the Republic of Korea, Malaysia and Thailand. About 7% of the worldwide natural gas reserves belong to Asia but this self-sufficiency will fall rapidly. This paper summarizes the forecasting and uncertainties of natural gas demand from Japan, South Korea, China and India by the year 2010. LNG producers such as Brunei and Australia but also Papua-New Guinea, Vietnam, Alaska and Middle East are ready to supply the Asian demand. (J.S.)

Kalimantan field development hikes gas supply for LNG export

International Nuclear Information System (INIS)

Suharmoko, G.R.

1991-01-01

This paper reports on the development of Tambora and Tunu gas fields in Kalimantan that have increased available gas supply for the export of liquefied natural gas (LNG) from Indonesia. The demand for LNG is increasing in the energy thirsty Far East market. And Indonesia, the world's largest exporter, is keeping pace by expanding the Bontang liquefaction plant in East Kalimantan. A fifth train, with a capacity of around 2.5 million tons/year, began operating in January 1990. Start-up of a sixth train, of identical capacity, is planned for January 1994. The Bontang plant is operated by PT Badak on behalf of Pertamina, the Indonesian state oil and gas mining company. The feed to the fifth train comes primarily from the first-phase development of Total Indonesie's two gas fields, Tambora and Tunu. The sixth train will be fed by a second-phase development of the Tunu field

Considerations for the optimization of induced white matter injury preclinical models

Directory of Open Access Journals (Sweden)

Abdullah Shafique Ahmad

2015-08-01

Full Text Available The white matter injury in relation to acute neurologic conditions, especially stroke, has remained obscure until recently. Current advances in the imaging technologies in the field of stroke have confirmed that white matter injury plays an important role in the prognosis of stroke and suggest that white matter protection is essential for functional recovery and post-stroke rehabilitation. However, due to the lack of a reproducible animal model of white matter injury, the pathophysiology and mechanisms of this injury are not well studied. Moreover, producing selective white matter injury in animals, especially in rodents, has proven to be challenging. Problems associated with inducing selective white matter ischemic injury in the rodent derive from differences in the architecture of the brain, most particularly the ratio of white matter to gray matter in rodents compared to humans, the agents used to induce the injury, and the location of the injury. Aging, gender differences, and comorbidities further add to this complexity. This review provides a brief account of the techniques commonly used to induce general white matter injury in animal models (stroke and non-stroke related and highlights relevance, optimization issues, and translational potentials associated with this particular form of injury.

Apoptosis-induced lymphopenia in sepsis and other severe injuries.

Science.gov (United States)

Girardot, Thibaut; Rimmelé, Thomas; Venet, Fabienne; Monneret, Guillaume

2017-02-01

Sepsis and other acute injuries such as severe trauma, extensive burns, or major surgeries, are usually followed by a period of marked immunosuppression. In particular, while lymphocytes play a pivotal role in immune response, their functions and numbers are profoundly altered after severe injuries. Apoptosis plays a central role in this process by affecting immune response at various levels. Indeed, apoptosis-induced lymphopenia duration and depth have been associated with higher risk of infection and mortality in various clinical settings. Therapies modulating apoptosis represent an interesting approach to restore immune competence after acute injury, although their use in clinical practice still presents several limitations. After briefly describing the apoptosis process in physiology and during severe injuries, we will explore the immunological consequences of injury-induced lymphocyte apoptosis, and describe associations with clinically relevant outcomes in patients. Therapeutic perspectives targeting apoptosis will also be discussed.

Cold recovery during regasification of LNG part two: Applications in an Agro Food Industry and a Hypermarket

International Nuclear Information System (INIS)

La Rocca, Vincenzo

2011-01-01

The paper deals with the cold energy available during LNG regasification, which can be recovered and utilized both inside the LNG regasification area and at a distance, such as in deep freezing agro food industry facilities and for space conditioning in the commercial and residential sector (e.g. Supermarkets and Hypermarkets). The feasibility study of this kind of application has been carried out at DREAM, Palermo University, within the framework of a research program. The results of a feasibility study of the kind of venture proposed, starting from its conceptual design and with a thorough thermodynamic and economic analysis, demonstrated the suitability and the profitability of the applications proposed. They seem very attractive due to expected wide future exploitation of LNG regasification in the World. -- Highlights: → Proposal pertaining cold recovery during LNG regasification. → Cold utilization far from the regasification site. → Transfer of liquid/gaseous carbon dioxide pipeline. → Exergetic and economic analysis of venture pertaining applications proposed. → Results of venture economic analysis.

LNG as a strategy to establish developing countries' gas markets: The Brazilian case

International Nuclear Information System (INIS)

Alberto Rechelo Neto, Carlos; Sauer, Ildo Luis

2006-01-01

This paper aims to evaluate, from a Brazilian case study, if the natural gas trade can be viewed as a good opportunity for developing countries located geographically close to Western Europe and North America gas markets. Initially, the paper presents an overview of the Brazilian natural gas industry and evaluates the balance between supply and demand in each main region of Brazil. Then, it analyzes the evolution of the international gas trade, which is expected to increase rapidly (LNG particularly). Finally, the paper analyses the financial viability of the Brazilian LNG project in a context of high volatility of natural gas prices in the international market. To take this uncertainty into account, North-American natural gas prices are modelled according to the ORNSTEIN-UHLENBECK process (with EIA data over the period 1985-2003). By using an approach based on Monte-Carlo simulations and under the assumption that imports are guaranteed since the North American gas price would be higher than the breakeven of the Brazilian project, the model aims to test the hypothesis that export can promote the development of the Brazilian Northeastern gas market. LNG project is here compared to the Petrobras pipelines project, which is considered as the immediate solution for the Northeastern gas shortage. As a conclusion, this study shows that the LNG export will be vulnerable to the risks associated to the natural gas prices volatility observed on the international market

A combined power cycle utilizing low-temperature waste heat and LNG cold energy

International Nuclear Information System (INIS)

Shi Xiaojun; Che Defu

2009-01-01

This paper has proposed a combined power system, in which low-temperature waste heat can be efficiently recovered and cold energy of liquefied natural gas (LNG) can be fully utilized as well. This system consists of an ammonia-water mixture Rankine cycle and an LNG power generation cycle, and it is modelled by considering mass, energy and species balances for every component and thermodynamic analyses are conducted. The results show that the proposed combined cycle has good performance, with net electrical efficiency and exergy efficiency of 33% and 48%, respectively, for a typical operating condition. The power output is equal to 1.25 MWh per kg of ammonia-water mixture. About 0.2 MW of electrical power for operating sea water pumps can be saved. Parametric analyses are performed for the proposed combined cycle to evaluate the effects of key factors on the performance of the proposed combined cycle through simulation calculations. Results show that a maximum net electrical efficiency can be obtained as the inlet pressure of ammonia turbine increases and the peak value increases as the ammonia mass fraction increases. Exergy efficiency goes up with the increased ammonia turbine inlet pressure. With the ammonia mass fraction increases, the net electrical efficiency increases, whereas exergy efficiency decreases. For increasing LNG turbine inlet pressure or heat source temperature, there is also a peak of net electrical efficiency and exergy efficiency. With the increase of LNG gas turbine outlet pressure, exergy efficiency increases while net electrical efficiency drops

77 FR 32962 - Gulf Coast LNG Export, LLC; Application for Long-Term Authorization To Export Domestically...

Science.gov (United States)

2012-06-04

... supply domestic demand for a century, even with significant exports of LNG. Gulf Coast contends that the... is not prohibited by U.S. law or policy. Gulf Coast seeks to export this LNG on its own behalf and...-going carrier, and with which trade is not prohibited by U.S. law or policy. In the alternative, Gulf...

Antioxidant protection of statins in acute kidney injury induced by sepsis

Directory of Open Access Journals (Sweden)

Franciele do Nascimento Santos

2014-10-01

Full Text Available Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control; SHAM+Statin (0.5 mg/kg simvastatin, orally; Sepsis (cecal puncture ligation – CPL; Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. Results The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality. Conclusion This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.

Helium Extraction from LNG End Flash

OpenAIRE

Kim, Donghoi

2014-01-01

Helium is an invaluable element as it is widely used in industry such as cryo-genics and welding due to its unique properties. However, helium shortage is expected in near future because of increasing demand and the anxiety of sup-ply. Consequently, helium production has attracted the attention of industry. The main source of He is natural gas and extracting it from LNG end-flash is considered as the most promising way of producing crude helium. Thus, many process suppliers have proposed proc...

Advanced evacuation model managed through fuzzy logic during an accident in LNG terminal

Energy Technology Data Exchange (ETDEWEB)

Stankovicj, Goran; Petelin, Stojan [Faculty for Maritime Studies and Transport, University of Ljubljana, Portorozh (Sierra Leone); others, and

2014-07-01

Evacuation of people located inside the enclosed area of an LNG terminal is a complex problem, especially considering that accidents involving LNG are potentially very hazardous. In order to create an evacuation model managed through fuzzy logic, extensive influence must be generated from safety analyses. A very important moment in the optimal functioning of an evacuation model is the creation of a database which incorporates all input indicators. The output result is the creation of a safety evacuation route which is active at the moment of the accident. (Author)

Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats.

Science.gov (United States)

Santoru, Francesca; Berretti, Roberta; Locci, Andrea; Porcu, Patrizia; Concas, Alessandra

2014-09-01

Allopregnanolone is a neurosteroid involved in depression, memory, social, and sexual behavior. We have previously demonstrated that treatment with a combination of ethinylestradiol (EE) and levonorgestrel (LNG), two compounds frequently used in hormonal contraception, decreased brain allopregnanolone concentrations. These changes may contribute to some of the emotional and sexual disorders observed in hormonal contraceptive users. We thus examined whether the reduction in allopregnanolone concentrations induced by long-term EE/LNG administration was associated with altered emotional, learning, social, and sexual behaviors. Rats were orally treated with a combination of EE (0.030 mg) and LNG (0.125 mg) once a day for 4 weeks and were subjected to behavioral tests 24 h after the last administration. EE/LNG treatment reduced immobility behavior in the forced swim test, without affecting sucrose preference and spatial learning and memory. In the resident-intruder test, EE/LNG-treated rats displayed a decrease in dominant behaviors associated with a reduction in social investigation. In the paced mating test, EE/LNG treated rats showed a reduction in proceptive behaviors, while the lordosis quotient was not affected. Progesterone, but not estradiol, administration to EE/LNG-treated rats increased sexual activity and cerebrocortical allopregnanolone concentrations. Prior administration of finasteride decreased allopregnanolone concentrations and abolished the increase in proceptivity induced by progesterone administration. The decrease in brain allopregnanolone concentrations induced by EE/LNG treatment is associated with a reduction in social behavior and sexual motivation in female rats. These results might be relevant to the side effects sometimes exhibited by women taking hormonal contraceptives.

Diphenhydramine as a Cause of Drug-Induced Liver Injury

Directory of Open Access Journals (Sweden)

Yunseok Namn

2017-01-01

Full Text Available Drug-induced liver injury (DILI is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases. We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications. A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice. Aspartate-aminotransferase and alanine-aminotransferase levels peaked above 20,000 IU/L and 5,000 IU/L, respectively. He developed coagulopathy but without altered mental status. Patient reported taking up to 400 mg diphenhydramine nightly, without concomitant acetaminophen, for insomnia. He denied taking other medications, supplements, antibiotics, and herbals. A thorough workup of liver injury ruled out viral hepatitis (including A, B, C, and E, autoimmune, toxic, ischemic, and metabolic etiologies including Wilson’s disease. A liver biopsy was consistent with DILI without evidence of iron or copper deposition. Diphenhydramine was determined to be the likely culprit. This is the first reported case of diphenhydramine-induced liver injury without concomitant use of acetaminophen.

Analysis of constraints to the introduction of LNG plants in the Brazilian electric sector; Analise dos condicionantes para a introducao de plantas a GNL no setor eletrico brasileiro

Energy Technology Data Exchange (ETDEWEB)

Cortes, Tatiane Moraes Pestana

2010-03-15

This work aims analyze the constraints to the introduction of LNG in the Brazilian energy matrix. Therefore, considers the current regulatory framework and the investments recently made by PETROBRAS to acquire LNG in the international market in order to supply power plants in the country. In order to assess the current status of the LNG plants in the electricity sector, factors are analyzed in terms of the natural gas industry and electric power industry, such as: storage, LNG contracts, operating dispatch, LNG plants pricing and operational flexibility. Despite the increase in LNG international trade and the prospect of using this product in Brazil, there are some challenges for the effective use of LNG plants by Brazilian electric sector. Some of the challenges are the need to review the methodology of calculating the cost benefit of LNG power plants. Another important challenge is to examine the use of underground storage and its influence in the operating dispatch of LNG plants. (author)

The effects of LNG imports on the North American natural gas market and the economy of Atlantic Canada

International Nuclear Information System (INIS)

Howard, P.H.; Kralovic, P.; McColl, D.C.; Mutysheva, D.; Stogran, M.; Ryan, P.C.; Brown, M.; Gardner, M.; Hanrahan, M.

2006-01-01

Liquefied natural gas (LNG) is natural gas that has been cooled to a point that it condenses in a liquid state. As such, it is economical to transport over long distances in specially designed double-hulled tankers. With record high price, high demand and tight supply of natural gas, LNG has attracted considerable attention in recent years, and trade is expected to be 18 per cent of North American gas supply by 2020. Volatility in North American natural gas markets is felt strongly along the east coast, with demand dominated by gas-fired power generation. There are 5 facilities proposed to import LNG into the Maritimes and the province of Quebec. These include the Bear Head and Keltic facilities in Nova Scotia, Canaport in New Brunswick and the Rabaska and Cacouna facilities in the province of Quebec. There is a need for a comprehensive analysis of east coast gas development, given the degree of uncertainty regarding significant investment in gas supply, demand, pipelines and LNG projects. This report examined many possible changes in regional marketplace conditions with particular attention to the effects on the economic viability of natural gas developments in Atlantic Canada; the impacts of LNG imports on capacities and flows in natural gas pipeline corridors; and, the influence of increased natural gas supplies on local and regional prices. In order to examine the impact of LNG imports on the development of the natural gas industry, this report provided a 15-year natural gas flow and price simulation for Atlantic Canada, New England and the Mid-Atlantic region. It considered how LNG imports may influence the development of compressed natural gas and the impact that CNG may have on regional markets and infrastructure. It was concluded that the most direct impacts the LNG facilities will have on Atlantic Canada, other than the impacts of terminal construction, jobs and tax revenue, will be the security of supply to area residents and the availability of gas

LNG Industry in Europe beset by uncertainties

International Nuclear Information System (INIS)

Forbes, A.

2007-01-01

Over the past five years, the liquefied natural gas industry (LNG) has metamorphosed from a specialist niche business into a mainstream source of energy supply, It is currently by far the fastest-growing source of fossil fuel and growth forecasts. However, the industry's future is beset by uncertainty, not least in Europe. Supply is tight, technical skills are hard to come by, and even future demand looks uncertain

Drug-induced liver injury

DEFF Research Database (Denmark)

Nielsen, Mille Bækdal; Ytting, Henriette; Skalshøi Kjær, Mette

2017-01-01

OBJECTIVE: The idiosyncratic subtype of drug-induced liver injury (DILI) is a rare reaction to medical treatment that in severe cases can lead to acute liver failure and death. The aim of this study was to describe the presentation and outcome of DILI and to identify potential predictive factors...... that DILI may be severe and run a fatal course, and that bilirubin and INR levels may predict poor outcome....

77 FR 48145 - Cameron Interstate Pipeline, LLC, Cameron LNG, LLC; Notice of Intent To Prepare an Environmental...

Science.gov (United States)

2012-08-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. PF12-12-000; PF12-13-000] Cameron Interstate Pipeline, LLC, Cameron LNG, LLC; Notice of Intent To Prepare an Environmental Impact Statement for the Planned Cameron Pipeline Expansion Project and Cameron LNG Liquefaction Project, Request for Comments on Environmental Issues,...

Role and mechanisms of autophagy in acetaminophen-induced liver injury.

Science.gov (United States)

Chao, Xiaojuan; Wang, Hua; Jaeschke, Hartmut; Ding, Wen-Xing

2018-04-23

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the USA and many other countries. Although the metabolism and pathogenesis of APAP has been extensively investigated for decades, the mechanisms by which APAP induces liver injury are incompletely known, which hampers the development of effective therapeutic approaches to tackle this important clinical problem. Autophagy is a highly conserved intracellular degradation pathway, which aims at recycling cellular components and damaged organelles in response to adverse environmental conditions and stresses as a survival mechanism. There is accumulating evidence indicating that autophagy is activated in response to APAP overdose in specific liver zone areas, and pharmacological activation of autophagy protects against APAP-induced liver injury. Increasing evidence also suggests that hepatic autophagy is impaired in nonalcoholic fatty livers (NAFLD), and NAFLD patients are more susceptible to APAP-induced liver injury. Here, we summarized the current progress on the role and mechanisms of autophagy in protecting against APAP-induced liver injury. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Melatonin mitigates neomycin-induced hair cell injury in zebrafish.

Science.gov (United States)

Oh, Kyoung Ho; Rah, Yoon Chan; Hwang, Kyu Ho; Lee, Seung Hoon; Kwon, Soon Young; Cha, Jae Hyung; Choi, June

2017-10-01

Ototoxicity due to medications, such as aminoglycosides, is irreversible, and free radicals in the inner ear are assumed to play a major role. Because melatonin has an antioxidant property, we hypothesize that it might mitigate hair cell injury by aminoglycosides. The objective of this study was to evaluate whether melatonin has an alleviative effect on neomycin-induced hair cell injury in zebrafish (Danio rerio). Various concentrations of melatonin were administered to 5-day post-fertilization zebrafish treated with 125 μM neomycin for 1 h. Surviving hair cells within four neuromasts were compared with that of a control group. Apoptosis was assessed via terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. The changes of ultrastructure were confirmed using a scanning electron microscope. Melatonin alleviated neomycin-induced hair cell injury in neuromasts (neomycin + melatonin 100 μM: 13.88 ± 0.91 cells, neomycin only: 7.85 ± 0.90 cells; n = 10, p melatonin for 1 h in SEM findings. Melatonin is effective in alleviating aminoglycoside-induced hair cell injury in zebrafish. The results of this study demonstrated that melatonin has the potential to reduce apoptosis induced by aminoglycosides in zebrafish.

Role of IRAK-M in alcohol induced liver injury.

Directory of Open Access Journals (Sweden)

Yipeng Wang

Full Text Available Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity. The main objective of this study was to investigate the negative regulator of innate immunity, IL-1/Toll-like receptor (TLR signaling pathways and interleukin receptor-associated kinase-M (IRAK-M in alcoholic liver injury. We established an alcohol-induced liver injury model using wild type and IRAK-M deficient B6 mice and investigated the possible mechanisms. We found that in the absence of IRAK-M, liver damage by alcohol was worse with higher alanine transaminase (ALT, more immune cell infiltration and increased numbers of IFNγ producing cells. We also found enhanced phagocytic activity in CD68(+ cells. Moreover, our results revealed altered gut bacteria after alcohol consumption and this was more striking in the absence of IRAK-M. Our study provides evidence that IRAK-M plays an important role in alcohol-induced liver injury and IRAK-M negatively regulates the innate and possibly the adaptive immune response in the liver reacting to acute insult by alcohol. In the absence of IRAK-M, the hosts developed worse liver injury, enhanced gut permeability and altered gut microbiota.

Ethanol extract from portulaca oleracea L. attenuated acetaminophen-induced mice liver injury

Science.gov (United States)

Liu, Xue-Feng; Zheng, Cheng-Gang; Shi, Hong-Guang; Tang, Gu-Sheng; Wang, Wan-Yin; Zhou, Juan; Dong, Li-Wei

2015-01-01

Acetaminophen-induced liver injury represents the most frequent cause of drug-induced liver failure in the world. Portulaca oleracea L., a widely distributed weed, has been used as a folk medicine in many countries. Previously, we reported that the ethanol extracts of Portulaca oleracea L. (PO) exhibited significant anti-hypoxic activity. In the present study, we investigated the role of PO on acetaminophen (APAP) induced hepatotoxicity. The results demonstrated that PO was an effective anti-oxidative agent, which could, to some extent, reverse APAP-induced hepatotoxicity by regulating the reactive oxygen species (ROS) in the liver of mice. At the same time, PO treatment significantly decreased mice serum levels of IL-6 and TNFα and their mRNA expression in liver tissue IL-α and TNFα play an important role during APAP-induced liver injury. Furthermore, PO inhibited APAP and TNFα-induced activation of JNK, whose activation play an important effect during APAP induced liver injury. These findings suggested that administration of PO may be an effective strategy to prevent or treat liver injury induced by APAP. PMID:25901199

76 FR 4885 - Freeport LNG Expansion, L.P. and FLNG Liquefaction, LLC Application for Long-Term Authorization...

Science.gov (United States)

2011-01-27

... order dated September 26, 2006 \\1\\: (1) A second marine berthing dock; (2) A third LNG storage tank; and... world.\\7\\ FLEX states that many natural gas and LNG supply contracts in European and Asian markets are... public interest. First, FLEX contends that the project will cause direct and indirect job creation...

Cold recovery during regasification of LNG part one: Cold utilization far from the regasification facility

International Nuclear Information System (INIS)

La Rocca, Vincenzo

2010-01-01

The paper deals with cold recovery during LNG regasification. The applications analyzed pertain to the use in deep freezing agro food industry and in space air conditioning facilities in commercial sector (Supermarkets and Hypermarkets) of cold recovered from the regasification process. A modular LNG regasification unit is proposed having the regasification capacity of 2 BCM/year of gas and it is based on use of a Power Cycle working with Ethane, this unit allows operation of cold energy transfer, contained in LNG to be regasified, in a range of temperatures suitable for multipurpose use of cold, reducing regasification process irreversibility. Some electric energy is produced by the Power Cycle, but the purpose of the modular unit is to deliver cold suitable for industrial and commercial use in the proper temperature range utilizing Carbon dioxide as secondary fluid to transfer cold from regasification site to far end users. The subject is divided in two papers: this paper deals with facilities delivering cold released during LNG regasification and related pipeline facilities to transfer cold at far end users while the other paper pertains to analysis of end users applications. Results of a detailed thermodynamic and economic analysis demonstrate the suitability of the proposal.

Public consultation by the French Energy Regulatory Commission of 14 September 2016 relating to the new tariffs for the use of regulated LNG terminals. Evolution of the ATM5 offer Proposals from Elengy and Fosmax LNG

International Nuclear Information System (INIS)

2016-01-01

The aim of this public consultation is to gather input from the market regarding the options envisaged by the CRE for the ATTM5 tariffs. These concern the tariff regulation framework, the level of tariffs and the structure of the tariff offerings of the LNG terminals. Items from the tariff documentation sent to the CRE by Elengy and Fosmax LNG would lead to a change in unit tariffs of -0.7% for Montoir, -13.9% for Fos Tonkin and -11.9% for Fos Cavaou. At this stage, with regard to the requests from Elengy and Fosmax LNG, the CRE is planning: - to adjust the trajectories of the net operational charges requested by the LNG terminal operators; - to decide on a weighted average cost of capital (WACC) equal to that of the transmission network operators, within a range from 4.75% to 5.5% actual before tax, plus a bonus reflecting the specific risks to LNG terminals, within a range from 1.0% to 2.4%. Depending on the rate of remuneration applied, and the direction of the net operational charges selected, the change in the ATTM5 tariff may be between -2.5% and -10.6% inclusive for Montoir, between -14.4% and -18.5% inclusive for Fos Tonkin and between -14.8% and -26.1% inclusive on average per year for Fos Cavaou. The CRE is planning the following schedule for drawing up the ATTM5 tariff and its entry into force: - this public consultation is open up to 14 October 2016; - the CRE's tariff deliberation, having consulted the French Higher Energy Council (CSE), will be adopted at the end of 2016; - the ATTM5 tariff will enter into force on 1 April 2017. At the same time as this public consultation, the CRE is publishing an audit of the request from LNG terminal operators on the rate of remuneration for the period of the ATTM5

Blast overpressure induced axonal injury changes in rat brainstem and spinal cord

Directory of Open Access Journals (Sweden)

Srinivasu Kallakuri

2015-01-01

Full Text Available Introduction: Blast induced neurotrauma has been the signature wound in returning soldiers from the ongoing wars in Iraq and Afghanistan. Of importance is understanding the pathomechansim(s of blast overpressure (OP induced axonal injury. Although several recent animal models of blast injury indicate the neuronal and axonal injury in various brain regions, animal studies related to axonal injury in the white matter (WM tracts of cervical spinal cord are limited. Objective: The purpose of this study was to assess the extent of axonal injury in WM tracts of cervical spinal cord in male Sprague Dawley rats subjected to a single insult of blast OP. Materials and Methods: Sagittal brainstem sections and horizontal cervical spinal cord sections from blast and sham animals were stained by neurofilament light (NF-L chain and beta amyloid precursor protein immunocytochemistry and observed for axonal injury changes. Results: Observations from this preliminary study demonstrate axonal injury changes in the form of prominent swellings, retraction bulbs, and putative signs of membrane disruptions in the brainstem and cervical spinal cord WM tracts of rats subjected to blast OP. Conclusions: Prominent axonal injury changes following the blast OP exposure in brainstem and cervical spinal WM tracts underscores the need for careful evaluation of blast induced injury changes and associated symptoms. NF-L immunocytochemistry can be considered as an additional tool to assess the blast OP induced axonal injury.

Failure analysis of storage tank component in LNG regasification unit using fault tree analysis method (FTA)

Science.gov (United States)

Mulyana, Cukup; Muhammad, Fajar; Saad, Aswad H.; Mariah, Riveli, Nowo

2017-03-01

Storage tank component is the most critical component in LNG regasification terminal. It has the risk of failure and accident which impacts to human health and environment. Risk assessment is conducted to detect and reduce the risk of failure in storage tank. The aim of this research is determining and calculating the probability of failure in regasification unit of LNG. In this case, the failure is caused by Boiling Liquid Expanding Vapor Explosion (BLEVE) and jet fire in LNG storage tank component. The failure probability can be determined by using Fault Tree Analysis (FTA). Besides that, the impact of heat radiation which is generated is calculated. Fault tree for BLEVE and jet fire on storage tank component has been determined and obtained with the value of failure probability for BLEVE of 5.63 × 10-19 and for jet fire of 9.57 × 10-3. The value of failure probability for jet fire is high enough and need to be reduced by customizing PID scheme of regasification LNG unit in pipeline number 1312 and unit 1. The value of failure probability after customization has been obtained of 4.22 × 10-6.

75 FR 57269 - Southern LNG Company, LLC; Notice of Intent To Prepare an Environmental Assessment for the...

Science.gov (United States)

2010-09-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP10-477-000] Southern LNG Company, LLC; Notice of Intent To Prepare an Environmental Assessment for the Proposed LNG Truck Loading Project and Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting September 13, 2010. The staff of the Federal Energ...

LNG trumped : the burst of enthusiasm for shale gas could put LNG on the sidelines of global gas trade

International Nuclear Information System (INIS)

McKenzie-Brown, P.

2010-01-01

The growing interest in shale gas is largely due to rapid innovation in down-hole technologies such as horizontal drilling, better bit design, coil tubing, down-hole motors, geosteering, microseismic, measurement while drilling tools and more powerful fracing systems. Despite these advances in shale gas technology, price will be the deciding factor in the competition between liquefied natural gas (LNG) and shale gas. This article discussed the 3 sources of gas that are of interest to North American producers. The first is the great success of shale gas production in the United States and Canada. The second is the evolution of a global market for LNG. This development has eliminated the need for pipelines to tie stranded gas into the world's industrial markets. For example, Qatar is developing liquefaction facilities for an offshore reservoir with more than a quadrillion cubic feet of proved reserves. The gas industry's third area of interest lies in the huge conventional gas reserves in Alaska and the Northwest Territories. However, there is doubt that any proposed pipelines to deliver the resources to southern markets will be built, particularly since shale gas formations like the Montney and Horn River have great potential and are located right next to existing infrastructure. 2 figs.

Gastric injury induced by hemorrhage, local ischemia, and oxygen radical generation

International Nuclear Information System (INIS)

Wadhwa, S.S.; Perry, M.A.

1987-01-01

Gastric mucosal injury caused by local intra-arterial generation of oxygen-derived free radicals was compared with gastric injury caused by 30 min of hemorrhage-induced ischemia or local ischemia. The index of injury was the loss of 51 Cr-labeled red cells across the gastric mucosa. Generation of oxygen radicals in the celiac artery caused a rapid increase in mucosal blood loss during the period of radical generation, and this loss was maintained after radical production ceased. Local ischemia produced similar mucosal injury; however, this occurred after reperfusion of the stomach and not during the ischemic episode. Hemorrhage-induced ischemia produced a threefold greater mucosal blood loss than local ischemia. The results of this study indicate that (1) oxygen radicals generated enzymatically in the blood supply to the stomach cause mucosal bleeding of similar magnitude to that observed after local ischemia and (2) that gastric ischemia induced by systemic hypotension produces more severe gastric injury than the same level of local hypotension

[Changes of menstruation patterns and adverse effects during the treatment of LNG-IUS for symptomatic adenomyosis].

Science.gov (United States)

Li, L; Leng, J H; Zhang, J J; Jia, S Z; Li, X Y; Shi, J H; Dai, Y; Zhang, J R; Li, T; Xu, X X; Liu, Z Z; You, S S; Chang, X Y; Lang, J H

2016-09-25

Objective: To investigate the changes of mestruation patterns and adverse effects during the treatment of levonorgestrel-releasing intrauterine system(LNG-IUS)for symptomatic adenomyosis in a prospective cohort study. Methods: From December, 2006 to December, 2014, patients of symptomatic adenomyosis diagnosed by transvaginal ultrasound in Peking Union Medical College Hospital were given LNG-IUS. Before and after placement of IUS, all patients' parameters were recorded, including carrying status of IUS, symptoms and scores of dysmenorrhea, menstruation scores, biochemical indicators, physical parameters, menstruation patterns and adverse effects. Risk factors for changes of menstruation patterns and adverse effects, and their impact on treatment effects were analyzed. Results: Totally 1 100 cases met inclusion criteria, with median age 36 years(range 20-44 years), median follow-up 35 months(range 1 -108 months). During follow-up changes of menstruation patterns increased significantly with amenorrhea and shortened-menstruation being the most common manifestations. On 3, 6, 12, 24, 36, 48 and 60 months after the placement of LNG-IUS, 0, 5.8%(43/744), 6.9%(47/682), 10.1%(60/595), 17.3%(87/502), 27.2%(104/383)and 29.6%(82/277)patients achieved amenorrhea respectively( P 12 months after placement, abdominal pain and body weight increasing ≥5 kg/year were the most common adverse effects. Changes of menstruation patterns, total and subclassifications of adverse effects were neither dependent on patient parameters, treatment modes and treatment effects, nor could predict future LNG-IUS carrying status(all P > 0.05). After taking out of LNG-IUS, most changes of menstruation and adverse effects disappeared. Conclusions: During the treatment of LNG-IUS for symptomatic adenomyosis, changes of menstruation patterns increase gradually with amenorrhea and shortened-menstruation being the most common manifestations, while adverse effects decrease significantly. Changes of

77 FR 7568 - Freeport LNG Expansion, L.P. and FLNG Liquefaction, LLC; Application for Long-Term Authorization...

Science.gov (United States)

2012-02-13

... that is sufficient to supply domestic demand for a century, even with significant exports of LNG. FLEX... is not prohibited by U.S. law or policy. The Application is filed independent of, and in addition to... application in Docket 10-161-LNG is 2.8 Bcf/d. FLEX further states that demand for liquefaction capacity has...

Radiated-induced brain injury: advance of molecular mechanisms and neuroprotection strategies

International Nuclear Information System (INIS)

Gao Bo; Wang Xuejian

2007-01-01

The underlying mechanisms of radiated-induced brain injury (RBI) remain incompletely clear. Pathophysiological data indicate that the development of RBI involves complex and dynamic interactions between neurons, glia, and vascular endothelial cells within thecentral nervous system (CNS). Radiated-induced injury in the CNS can be modulated by the therapies directed at altering steps in the cascade of events leading to the clinical expression of normal tissue injury. Some neuroprotective strategies are also addressed in the review. (authors)

Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice

Directory of Open Access Journals (Sweden)

Xin-Jing Yang

2018-01-01

Full Text Available Background. Tanshinone IIA sodium sulfonate (TSS is known to possess anti-inflammatory effects and has exhibited protective effects in various inflammatory conditions; however, its role in lipopolysaccharide- (LPS- induced intestinal injury is still unknown. Objective. The present study is designed to explore the role and possible mechanism of TSS in LPS-induced intestinal injury. Methods. Male C57BL/6J mice, challenged with intraperitoneal LPS injection, were treated with or without TSS 0.5 h prior to LPS exposure. At 1, 6, and 12 h after LPS injection, mice were sacrificed, and the small intestine was excised. The intestinal tissue injury was analyzed by HE staining. Inflammatory factors (TNF-α, IL-1β, and IL-6 in the intestinal tissue were examined by ELISA and RT-PCR. In addition, expressions of autophagy markers (microtubule-associated light chain 3 (LC3 and Beclin-1 were detected by western blot and RT-PCR. A number of autophagosomes were also observed under electron microscopy. Results. TSS treatment significantly attenuated small intestinal epithelium injury induced by LPS. LPS-induced release of inflammatory mediators, including TNF-α, IL-1β, and IL-6, were markedly inhibited by TSS. Furthermore, TSS treatment could effectively upregulate LPS-induced decrease of autophagy levels, as evidenced by the increased expression of LC3 and Beclin-1, and more autophagosomes. Conclusion. The protective effect of TSS on LPS-induced small intestinal injury may be attributed to the inhibition of inflammatory factors and promotion of autophagy levels. The present study may provide novel insight into the molecular mechanisms of TSS on the treatment of intestinal injury.

Developing safe and reliable LNG supply chains in teh new global environment: experience and lessons from six continents

Energy Technology Data Exchange (ETDEWEB)

Meyer, Ernst; Danielsen, Hans Kristian; Dweck, Jacob; Mareino, Vince; Eriksen, Remi

2007-07-01

This paper explores the dynamics of risk management in the context of specific recent experiences in the liquefied natural gas (LNG) business. The paper notes the overall success of the LNG business in ensuring safety and reliability, and highlights the opportunities and dangers of recent business growth. Risks are organised by theme, with focuses on politics and regulation, safety and security, environmental impact, public perception, technological innovation, cost and time management, competence and quality of assets, and harsh climates. Developers and other stakeholders are encouraged to draw lessons from these experiences when attempting to model the interplay of social, commercial and technical factors in LNG project development. (auth)

Desain Rantai Pasok Gas Alam Cair (LNG untuk Kebutuhan Pembangkit Listrik di Indonesia Bagian Timur

Directory of Open Access Journals (Sweden)

Made Arya Satya Dharma Putra

2017-01-01

Full Text Available Indonesia merupakan negara yang memiliki gas alam yang melimpah, namun kurangnya kesadaran masyarakat Indonesia untuk memanfaatkan gas tersebut untuk kebutuhan listrik di Indonesia yang sekarang sedang dalam krisis terutama di Indonesia Timur. Salah satu penyebab krisis tenaga listrik yang terjadi di Indonesia adalah tingginya nilai harga bahan bakar minyak, dimana High Speed Diesel Oil merupakan bahan bakar utama bagi pembangkit listrik di Indonesia. Gas alam cair atau Liquefied Natural Gas (LNG dapat menjadi solusi alternatif bahan bakar bagi pembangkit listrik di Indonesia.Studi kali ini bertujuan untuk pemanfaatan gas alam cair (LNG untuk kebutuhan pembangkit listrik di Indonesia Timur dengan menentukan pola distribusi LNG dengan menggunakan Blok Masela sebagai sumber LNG dan menggunakan kapal untuk mendistribusikannya. Terdapat 39 pembangkit yang tersebar di 4 pulau yaitu Maluku, Nusa Tenggara Barat, Nusa Tenggara Timur, dan Papua. Kapal yang digunakan untuk mendistribusikan terdapat 5 kapal dengan ukuran 2500 m3, 7500 m3, 10000 m3, 19500 m3, 23000 m3. Untuk mendapatkan rute distribusi, studi ini menggunakan metode Linear Programing dan dalam Vehicle Routing Problem. Hasil optimasi pada distribusi ini adalah rute dan kapal yang optimal / terbaik dengan biaya ekonomi yang minimal.Dari hasil penelitian ini pembangkit akan dibagi menjadi 5 cluster dimana terdapat 5 rute yang terpilih dengan menggunakan 6 kapal yaitu 5 kapal ukuran 2500 m3 dan 1 kapal dengan ukuran 7500m3. Biaya total yang diperlukan dalam mendistribusikan LNG sebesar US$ 111,863,119.15 untuk Opex dan US$ 283,967,000.00 untuk Capex. Hasil dari kajian ekonomi menunjukan bahwa margin penjualan yang terpilih adalah antara US$ 3.5 sampai US$ 3.9 dengan payback period selama 6.8 – 4.7 tahun tahun dari waktu operasi 20 tahun.

H_2 production by the steam reforming of excess boil off gas on LNG vessels

International Nuclear Information System (INIS)

Fernández, Ignacio Arias; Gómez, Manuel Romero; Gómez, Javier Romero; López-González, Luis M.

2017-01-01

Highlights: • BOG excess in LNG vessels is burned in the GCU without energy use. • The gas management plants need to be improved to increase efficiency. • BOG excess in LNG vessels is used for H_2 production by steam reforming. • The availability of different fuels increases the versatility of the ship. - Abstract: The gas management system onboard LNG (Liquid Natural Gas) vessels is crucial, since the exploitation of the BOG (Boil Off Gas) produced is of utmost importance for the overall efficiency of the plant. At present, LNG ships with no reliquefaction plant consume the BOG generated in the engines, and the excess is burned in the GCU (Gas Combustion Unit) without any energy use. The need to improve the gas management system, therefore, is evident. This paper proposes hydrogen production through a steam reforming plant, using the excess BOG as raw material and thus avoiding it being burned in the GCU. To test the feasibility of integrating the plant, an actual study of the gas management process on an LNG vessel with 4SDF (4 Stroke Dual Fuel) propulsion and with no reliquefaction plant was conducted, along with a thermodynamic simulation of the reforming plant. With the proposed gas management system, the vessel disposes of different fuels, including H_2, a clean fuel with zero ozone-depleting emissions. The availability of H_2 on board in areas with strict anti-pollution regulations, such as ECAs (Emission Control Area), means that the vessel may be navigated without using fossil fuels which generate CO_2 and SO_X emissions. Moreover, while at port, Cold Ironing is avoided, which entails high costs. Thus it is demonstrated that the installation of a reforming plant is both energetically viable and provides greater versatility to the ship.

Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury.

Science.gov (United States)

Keskin, Ilknur; Gunal, M Yalcin; Ayturk, Nilufer; Kilic, Ulkan; Ozansoy, Mehmet; Kilic, Ertugrul

2017-05-01

Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.

Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats.

Science.gov (United States)

Suyama, Yosuke; Handa, Osamu; Naito, Yuji; Takayama, Shun; Mukai, Rieko; Ushiroda, Chihiro; Majima, Atsushi; Yasuda-Onozawa, Yuriko; Higashimura, Yasuki; Fukui, Akifumi; Dohi, Osamu; Okayama, Tetsuya; Yoshida, Naohisa; Katada, Kazuhiro; Kamada, Kazuhiro; Uchiyama, Kazuhiko; Ishikawa, Takeshi; Takagi, Tomohisa; Konishi, Hideyuki; Itoh, Yoshito

2018-03-25

Acetyl salicylic acid (ASA) is a useful drug for the secondary prevention of cerebro-cardiovascular diseases, but it has adverse effects on the small intestinal mucosa. The pathogenesis and prophylaxis of ASA-induced small intestinal injury remain unclear. In this study, we focused on the intestinal mucus, as the gastrointestinal tract is covered by mucus, which exhibits protective effects against various gastrointestinal diseases. ASA was injected into the duodenum of rats, and small intestinal mucosal injury was evaluated using Evans blue dye. To investigate the importance of mucus, Polysorbate 80 (P80), an emulsifier, was used before ASA injection. In addition, rebamipide, a mucus secretion inducer in the small intestine, was used to suppress mucus reduction in the small intestine of P80-administered rats. The addition of P80 reduced the mucus and exacerbated the ASA-induced small intestinal mucosal injury. Rebamipide significantly suppressed P80-reduced small intestinal mucus and P80-increased intestinal mucosal lesions in ASA-injected rats, demonstrating that mucus is important for the protection against ASA-induced small intestinal mucosal injury. These results provide new insight into the mechanism of ASA-induced small intestinal mucosal injury. Mucus secretion-increasing therapy might be useful in preventing ASA-induced small intestinal mucosal injury. Copyright © 2018 Elsevier Inc. All rights reserved.

Acetaminophen-induced acute liver injury in HCV transgenic mice

International Nuclear Information System (INIS)

Uehara, Takeki; Kosyk, Oksana; Jeannot, Emmanuelle; Bradford, Blair U.; Tech, Katherine; Macdonald, Jeffrey M.; Boorman, Gary A.; Chatterjee, Saurabh; Mason, Ronald P.; Melnyk, Stepan B.; Tryndyak, Volodymyr P.; Pogribny, Igor P.; Rusyn, Ivan

2013-01-01

The exact etiology of clinical cases of acute liver failure is difficult to ascertain and it is likely that various co-morbidity factors play a role. For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure. However, little is known about possible mechanisms of enhanced acetaminophen hepatotoxicity in HCV-infected subjects. In this study, we tested a hypothesis that HCV-Tg mice may be more susceptible to acetaminophen hepatotoxicity, and also evaluated the mechanisms of acetaminophen-induced liver damage in wild type and HCV-Tg mice expressing core, E1 and E2 proteins. Male mice were treated with a single dose of acetaminophen (300 or 500 mg/kg in fed animals; or 200 mg/kg in fasted animals; i.g.) and liver and serum endpoints were evaluated at 4 and 24 h after dosing. Our results suggest that in fed mice, liver toxicity in HCV-Tg mice is not markedly exaggerated as compared to the wild-type mice. In fasted mice, greater liver injury was observed in HCV-Tg mice. In fed mice dosed with 300 mg/kg acetaminophen, we observed that liver mitochondria in HCV-Tg mice exhibited signs of dysfunction showing the potential mechanism for increased susceptibility. -- Highlights: ► Acetaminophen-induced liver injury is a significant clinical challenge. ► HCV-infected subjects may be at higher risk for acetaminophen-induced liver injury. ► We used HCV transgenics to test if liver injury due to acetaminophen is exacerbated.

Acetaminophen-induced acute liver injury in HCV transgenic mice

Energy Technology Data Exchange (ETDEWEB)

Uehara, Takeki; Kosyk, Oksana; Jeannot, Emmanuelle; Bradford, Blair U. [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599 (United States); Tech, Katherine; Macdonald, Jeffrey M. [Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599 (United States); Boorman, Gary A. [Covance, Chantilly, VA 20151 (United States); Chatterjee, Saurabh; Mason, Ronald P. [Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, RTP, NC 27713 (United States); Melnyk, Stepan B. [Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72201 (United States); Tryndyak, Volodymyr P.; Pogribny, Igor P. [Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079 (United States); Rusyn, Ivan, E-mail: iir@unc.edu [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599 (United States)

2013-01-15

The exact etiology of clinical cases of acute liver failure is difficult to ascertain and it is likely that various co-morbidity factors play a role. For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure. However, little is known about possible mechanisms of enhanced acetaminophen hepatotoxicity in HCV-infected subjects. In this study, we tested a hypothesis that HCV-Tg mice may be more susceptible to acetaminophen hepatotoxicity, and also evaluated the mechanisms of acetaminophen-induced liver damage in wild type and HCV-Tg mice expressing core, E1 and E2 proteins. Male mice were treated with a single dose of acetaminophen (300 or 500 mg/kg in fed animals; or 200 mg/kg in fasted animals; i.g.) and liver and serum endpoints were evaluated at 4 and 24 h after dosing. Our results suggest that in fed mice, liver toxicity in HCV-Tg mice is not markedly exaggerated as compared to the wild-type mice. In fasted mice, greater liver injury was observed in HCV-Tg mice. In fed mice dosed with 300 mg/kg acetaminophen, we observed that liver mitochondria in HCV-Tg mice exhibited signs of dysfunction showing the potential mechanism for increased susceptibility. -- Highlights: ► Acetaminophen-induced liver injury is a significant clinical challenge. ► HCV-infected subjects may be at higher risk for acetaminophen-induced liver injury. ► We used HCV transgenics to test if liver injury due to acetaminophen is exacerbated.

An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury

Directory of Open Access Journals (Sweden)

Reza Heidari

2015-03-01

Full Text Available Drug-induced liver injury (DILI is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied. Elucidating the mechanisms of DILI will allow clinicians to prevent liver failure, need for liver transplantation, and death induced by drugs. Methimazole and propylthiouracil (PTU are two convenient antithyroid agents which their administration is accompanied by hepatotoxicity as a deleterious side effect. Although several cases of antithyroid drugs-induced liver injury are reported, there is no clear idea about the mechanism(s of hepatotoxicity induced by these medications. Different mechanisms such as reactive metabolites formation, oxidative stress induction, intracellular targets dysfunction, and immune-mediated toxicity are postulated to be involved in antithyroid agents-induced hepatic damage. Due to the idiosyncratic nature of antithyroid drugs-induced hepatotoxicity, it is impossible to draw a specific conclusion about the mechanisms of liver injury. However, it seems that reactive metabolite formation and immune-mediated toxicity have a great role in antithyroids liver toxicity, especially those caused by methimazole. This review attempted to discuss different mechanisms proposed to be involved in the hepatic injury induced by antithyroid drugs.

Minocycline Attenuates Iron-Induced Brain Injury.

Science.gov (United States)

Zhao, Fan; Xi, Guohua; Liu, Wenqaun; Keep, Richard F; Hua, Ya

2016-01-01

Iron plays an important role in brain injury after intracerebral hemorrhage (ICH). Our previous study found minocycline reduces iron overload after ICH. The present study examined the effects of minocycline on the subacute brain injury induced by iron. Rats had an intracaudate injection of 50 μl of saline, iron, or iron + minocycline. All the animals were euthanized at day 3. Rat brains were used for immunohistochemistry (n = 5-6 per each group) and Western blotting assay (n = 4). Brain swelling, blood-brain barrier (BBB) disruption, and iron-handling proteins were measured. We found that intracerebral injection of iron resulted in brain swelling, BBB disruption, and brain iron-handling protein upregulation (p minocycline with iron significantly reduced iron-induced brain swelling (n = 5, p Minocycline significantly decreased albumin protein levels in the ipsilateral basal ganglia (p minocycline co-injected animals. In conclusion, the present study suggests that minocycline attenuates brain swelling and BBB disruption via an iron-chelation mechanism.

How the Norwegian Maritime Sector can succeed in internationalizing LNG-technology to Southeast Asia: A Case Study of Rolls-Royce Marine

OpenAIRE

Tveten, Rolf Erik; Løset, Gaute Dag

2012-01-01

The future potential of LNG as a bunker fuel in the Southeast Asian market is huge, although it is still immature. An emerging market for LNG-propulsion in the region creates a business opportunity for Norwegian companies delivering relevant products and services. This is a summary of the strategy that will yield the highest return on a foreign market entry with focus on export of LNG-technology in the Southeast Asian region. This thesis has assessed the gas producing and consuming countries,...

Effect of heme oxygenase-1 on radiation-induced skin injury

International Nuclear Information System (INIS)

Song Chuanjun; Meng Xingjun; Xie Ling; Chen Qing; Zhou Jundong; Zhang Shuyu; Wu Jinchang

2012-01-01

Objective: To investigate the effect of heme oxygenase-1 (HO-1) on the acute radiation-induced skin injury by gene transfer. Methods: Thirty-three male SD rats were randomly divided into three groups as PBS-injected group, Ad-EGFP-injected group and Ad-HO-1-injected group (n=11). In each group, three rats were used for determining the expression of target gene and the other rats were irradiated on the buttock skin with 40 Gy electron beam generated by a linear accelerator. Immediately after irradiation, rats were administered with a subcutaneous injection of PBS, Ad-EGFP or Ad-HO-1, respectively. Subsequently, the skin reactions were measured twice a week using the semi-quantitative skin injury scale. Results: The strong positive expression of HO-1 was observed in subcutaneous dermal tissue after injection of Ad-HO-1. Compared to the PBS-injected group or the Ad-EGFP-injected group, a significant mitigation of skin injury was observed in Ad-HO-1-injected mice 14 d after irradiation (q=0.000-0.030, P<0.05). Conclusions: HO-1 could significantly mitigate radiation-induced acute skin injury and Ad-HO-1 could be used to treat radiation-induced skin injury. (authors)

Evolving natural gas markets: LNG possibilities for a hydrothermal power system

Energy Technology Data Exchange (ETDEWEB)

Correia, Tiago B.; Resende, Joao P.; Costa, Agnes M. [Brazilian Ministry of Mines and Energy, Brasilia, DF (Brazil)

2008-07-01

The latest advancements in the natural gas - NG industry have brought new opportunities for the resource's application, especially in the power industry. On the one hand, rapid growth in demand and falling costs of transportation over long distances, particularly as liquefied natural gas - LNG, should lead to a more integrated NG world market. On the other, the deregulation of electricity markets and the growth of independent power producers - IPPs using NG as a fuel for generating peak load power have increased the demand for more flexible NG supply contracts. These factors have allowed a shift in the timing of investment and contract negotiation in NG market. Traditionally, firms searched for trading partners and signed long-term contracts before investing in infrastructure. In the evolving LNG market, producers invest in infrastructure before they have buyers for all their expected outputs, while buyers undertake investment before having firm contracts for all their expected NG needs. These technological and market changes may foster greater participation of a fully flexible NG power plants in the Brazilian electricity market. Nowadays, thermal power long-term capacity contracts customized and negotiated in the local electricity pool (ACR) require power producer to award guarantees of NG firm supply, substantially increasing their cost. A combination of flexible LNG supply contracts and electricity pool contracts may present a solution to the lack of competitiveness of NG power plants in the Brazilian power industry. (author)

Pressure induced deep tissue injury explained

NARCIS (Netherlands)

Oomens, C.W.J.; Bader, D.L.; Loerakker, S.; Baaijens, F.P.T.

The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This

Pathophysiological Responses in Rat and Mouse Models of Radiation-Induced Brain Injury.

Science.gov (United States)

Yang, Lianhong; Yang, Jianhua; Li, Guoqian; Li, Yi; Wu, Rong; Cheng, Jinping; Tang, Yamei

2017-03-01

The brain is the major dose-limiting organ in patients undergoing radiotherapy for assorted conditions. Radiation-induced brain injury is common and mainly occurs in patients receiving radiotherapy for malignant head and neck tumors, arteriovenous malformations, or lung cancer-derived brain metastases. Nevertheless, the underlying mechanisms of radiation-induced brain injury are largely unknown. Although many treatment strategies are employed for affected individuals, the effects remain suboptimal. Accordingly, animal models are extremely important for elucidating pathogenic radiation-associated mechanisms and for developing more efficacious therapies. So far, models employing various animal species with different radiation dosages and fractions have been introduced to investigate the prevention, mechanisms, early detection, and management of radiation-induced brain injury. However, these models all have limitations, and none are widely accepted. This review summarizes the animal models currently set forth for studies of radiation-induced brain injury, especially rat and mouse, as well as radiation dosages, dose fractionation, and secondary pathophysiological responses.

Obeticholic acid protects mice against lipopolysaccharide-induced liver injury and inflammation.

Science.gov (United States)

Xiong, Xi; Ren, Yuqian; Cui, Yun; Li, Rui; Wang, Chunxia; Zhang, Yucai

2017-12-01

Cholestasis, as a main manifestation, induces liver injury during sepsis. The farnesoid X receptor (FXR) plays an important role in regulating bile acid homeostasis. Whether FXR activation by its agonist obeticholic acid (OCA) is contributed to improve sepsis-induced liver injury remains unknown. The aim of the present study was to investigate the effect of OCA on lipopolysaccharide (LPS)-induced acute liver injury in mice. 8-week old male C57BL/6J mice were randomly divided into control group, LPS group, oral OCA group and LPS plus oral OCA (LPS + OCA) group. The serum and livers were collected for further analysis. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA) and total bilirubin (TBIL) were measured at indicated time after LPS administration. Liver sections were stained with hematoxylin & eosin (H&E). Orally OCA pretreatment stimulated the expression of FXR and BSEP in livers and protected mice from LPS-induced hepatocyte apoptosis and inflammatory infiltration. Consistently, LPS-induced higher serum levels of ALT, AST, TBA and TBIL were significantly reversed by OCA administration. Meanwhile, the mRNA levels of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α) and IL-6 were decreased in livers of mice in LPS + OCA group compared with LPS group. Further investigation indicated that the higher expression of ATF4 and LC3II/I were associated with the protective effect of OCA on LPS-induced liver injury. Orally OCA pretreatment protects mice from LPS-induced liver injury possibly contributed by improved bile acid homeostasis, decreased inflammatory factors and ATF4-mediated autophagy activity in hepatocytes. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Neuroprotective Treatment of Laser-Induced Retinal Injuries

National Research Council Canada - National Science Library

Rosner, Mordechai

2001-01-01

.... It is not possible to prevent all these injuries and there is no treatment. This study was designed to evaluate the neuroprotective effect of dextromethorphan, memantine and brimonidine in our rat model of laser- induced retinal-lesions Methods...

Factors affecting drug-induced liver injury: antithyroid drugs as instances

Directory of Open Access Journals (Sweden)

Reza Heidari

2014-09-01

Full Text Available Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.

Vildagliptin-induced acute lung injury: a case report.

Science.gov (United States)

Ohara, Nobumasa; Kaneko, Masanori; Sato, Kazuhiro; Maruyama, Ryoko; Furukawa, Tomoyasu; Tanaka, Junta; Kaneko, Kenzo; Kamoi, Kyuzi

2016-08-12

Dipeptidyl peptidase-4 inhibitors are a class of oral hypoglycemic drugs and are used widely to treat type 2 diabetes mellitus in many countries. Adverse effects include nasopharyngitis, headache, elevated serum pancreatic enzymes, and gastrointestinal symptoms. In addition, a few cases of interstitial pneumonia associated with their use have been reported in the Japanese literature. Here we describe a patient who developed drug-induced acute lung injury shortly after the administration of the dipeptidyl peptidase-4 inhibitor vildagliptin. A 38-year-old Japanese woman with diabetes mellitus developed acute respiratory failure 1 day after administration of vildagliptin. Chest computed tomography revealed nonsegmental ground-glass opacities in her lungs. There was no evidence of bacterial pneumonia or any other cause of her respiratory manifestations. After discontinuation of vildagliptin, she recovered fully from her respiratory disorder. She received insulin therapy for her diabetes mellitus, and her subsequent clinical course has been uneventful. The period of drug exposure in previously reported cases of patients with drug-induced interstitial pneumonia caused by dipeptidyl peptidase-4 inhibitor varied from several days to over 6 months. In the present case, our patient developed interstitial pneumonia only 1 day after the administration of vildagliptin. The precise mechanism of her vildagliptin-induced lung injury remains uncertain, but physicians should consider that dipeptidyl peptidase-4 inhibitor-induced lung injury, although rare, may appear acutely, even within days after administration of this drug.

Electric power generation and LNG evaporation with the aid of gas turbines within a closed-cycle process. [In German

Energy Technology Data Exchange (ETDEWEB)

Weber, D

1978-01-01

LNG, after being pumped to customary pipeline pressure, has a high working potential which can be technically utilized. Thus, in a modern large-size terminal, a power potential in the order of magnitude of several hundred MW is available. In the course of rising power prices the question becomes important if this potential continues to be wasted or if conversion to electric power is economical. In the proposed process the working fluid of a gas turbine plant with a closed circuit is cooled to -140/sup 0/C with LNG before entering the compressor and heated to +720/sup 0/C before entering the turbine by means of external heat gained by burning natural gas. With a 1 million m/sup 3//h throughput of LNG in its normal state, 237 MW of electric power can be generated with 53% efficiency with this simple circuit, which can be further developed. In a combination of closed gas turbine and diesel generator, almost 289 MW of electric power can be produced per 1 million m/sup 3//h LNG with an efficiency of 60%.

Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration

Directory of Open Access Journals (Sweden)

Jung Hyun Park

2017-01-01

Full Text Available Acrolein is known to be involved in acute lung injury and other pulmonary diseases. A number of studies have suggested that acrolein-induced toxic effects are associated with depletion of antioxidants, such as reduced glutathione and protein thiols, and production of reactive oxygen species. Mitochondrial NADP+-dependent isocitrate dehydrogenase (idh2 regulates mitochondrial redox balance and reduces oxidative stress-induced cell injury via generation of NADPH. Therefore, we evaluated the role of idh2 in acrolein-induced lung injury using idh2 short hairpin RNA- (shRNA- transfected Lewis lung carcinoma (LLC cells and idh2-deficient (idh2−/− mice. Downregulation of idh2 expression increased susceptibility to acrolein via induction of apoptotic cell death due to elevated mitochondrial oxidative stress. Idh2 deficiency also promoted acrolein-induced lung injury in idh2 knockout mice through the disruption of mitochondrial redox status. In addition, acrolein-induced toxicity in idh2 shRNA-transfected LLC cells and in idh2 knockout mice was ameliorated by the antioxidant, N-acetylcysteine, through attenuation of oxidative stress resulting from idh2 deficiency. In conclusion, idh2 deficiency leads to mitochondrial redox environment deterioration, which causes acrolein-mediated apoptosis of LLC cells and acrolein-induced lung injury in idh2−/− mice. The present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung.

Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration.

Science.gov (United States)

Park, Jung Hyun; Ku, Hyeong Jun; Lee, Jin Hyup; Park, Jeen-Woo

2017-01-01

Acrolein is known to be involved in acute lung injury and other pulmonary diseases. A number of studies have suggested that acrolein-induced toxic effects are associated with depletion of antioxidants, such as reduced glutathione and protein thiols, and production of reactive oxygen species. Mitochondrial NADP + -dependent isocitrate dehydrogenase ( idh2 ) regulates mitochondrial redox balance and reduces oxidative stress-induced cell injury via generation of NADPH. Therefore, we evaluated the role of idh2 in acrolein-induced lung injury using idh2 short hairpin RNA- (shRNA-) transfected Lewis lung carcinoma (LLC) cells and idh2 -deficient ( idh2 -/- ) mice. Downregulation of idh2 expression increased susceptibility to acrolein via induction of apoptotic cell death due to elevated mitochondrial oxidative stress. Idh2 deficiency also promoted acrolein-induced lung injury in idh2 knockout mice through the disruption of mitochondrial redox status. In addition, acrolein-induced toxicity in idh2 shRNA-transfected LLC cells and in idh2 knockout mice was ameliorated by the antioxidant, N-acetylcysteine, through attenuation of oxidative stress resulting from idh2 deficiency. In conclusion, idh2 deficiency leads to mitochondrial redox environment deterioration, which causes acrolein-mediated apoptosis of LLC cells and acrolein-induced lung injury in idh2 -/- mice. The present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung.

Radiation-induced brain injury: A review

Directory of Open Access Journals (Sweden)

Michael eRobbins

2012-07-01

Full Text Available Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (> 6 months to experience radiation-induced brain injury. Prior to 1970, the human brain was thought to be highly radioresistant; the acute CNS syndrome occurs after single doses > 30 Gy; white matter necrosis occurs at fractionated doses > 60 Gy. Although white matter necrosis is uncommon with modern techniques, functional deficits, including progressive impairments in memory, attention, and executive function have become important, because they have profound effects on quality of life. Preclinical studies have provided valuable insights into the pathogenesis of radiation-induced cognitive impairment. Given its central role in memory and neurogenesis, the majority of these studies have focused on the hippocampus. Irradiating pediatric and young adult rodent brains leads to several hippocampal changes including neuroinflammation and a marked reduction in neurogenesis. These data have been interpreted to suggest that shielding the hippocampus will prevent clinical radiation-induced cognitive impairment. However, this interpretation may be overly simplistic. Studies using older rodents, that more closely match the adult human brain tumor population, indicate that, unlike pediatric and young adult rats, older rats fail to show a radiation-induced decrease in neurogenesis or a loss of mature neurons. Nevertheless, older rats still exhibit cognitive impairment. This occurs in the absence of demyelination and/or white matter necrosis similar to what is observed clinically, suggesting that more subtle molecular, cellular and/or microanatomic modifications are involved in this radiation-induced brain injury. Given that radiation-induced cognitive impairment likely reflects damage to both hippocampal- and non-hippocampal-dependent domains, there is a critical need to investigate the microanatomic and functional effects of radiation in various brain

Comparison between reverse Brayton and Kapitza based LNG boil-off gas reliquefaction system using exergy analysis

Science.gov (United States)

Kochunni, Sarun Kumar; Chowdhury, Kanchan

2017-02-01

LNG boil-off gas (BOG) reliquefaction systems in LNG carrier ships uses refrigeration devices which are based on reverse Brayton, Claude, Kapitza (modified Claude) or Cascade cycles. Some of these refrigeration devices use nitrogen as the refrigerants and hence nitrogen storage vessels or nitrogen generators needs to be installed in LNG carrier ships which consume space and add weight to the carrier. In the present work, a new configuration based on Kapitza liquefaction cycle which uses BOG itself as working fluid is proposed and has been compared with Reverse Brayton Cycle (RBC) on sizes of heat exchangers and compressor operating parameters. Exergy analysis is done after simulating at steady state with Aspen Hysys 8.6® and the comparison between RBC and Kapitza may help designers to choose reliquefaction system with appropriate process parameters and sizes of equipment. With comparable exergetic efficiency as that of an RBC, a Kaptiza system needs only BOG compressor without any need of nitrogen gas.

Simulation of a Novel Single-column Cryogenic Air Separation Process Using LNG Cold Energy

Science.gov (United States)

Jieyu, Zheng; Yanzhong, Li; Guangpeng, Li; Biao, Si

In this paper, a novel single-column air separation process is proposed with the implementation of heat pump technique and introduction of LNG coldenergy. The proposed process is verifiedand optimized through simulation on the Aspen Hysys® platform. Simulation results reveal that thepower consumption per unit mass of liquid productis around 0.218 kWh/kg, and the total exergy efficiency of the systemis 0.575. According to the latest literatures, an energy saving of 39.1% is achieved compared with those using conventional double-column air separation units.The introduction of LNG cold energy is an effective way to increase the system efficiency.

FY1995 research report on the survey of cryogenic energy utilization systems for environmentally friendly energy community project. Case studies of LNG cryogenic energy cascade-wise utilization; 1995 nendo kankyo chowagata energycommunity jigyo ni kakawaru reinetsu riyo system kento chosa hokokusho. LNG reinetsu no cascade teki riyo case study

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

Japan's import of LNG (liquefied natural gas) has increased in these 15 years from 13-million tons to 43-million tons at a high rate of 2-million tons a year. At present LNG is used only in power generation and town gas business, and its cryogenic feature which may be useful in various fields is not being utilized. In this survey, factors impeding the wider application of the cryogenic energy are investigated, methods for using the energy more widely and mechanisms required therefor are studied, and discussion is made about the feasibility of the utilization of the energy in a cascade-wise form under the environmentally friendly energy community project. Researches are conducted and the results are evaluated in a study carried out on the comprehensive utilization of LNG cryogenic energy. These researches involve the actualities and trends of LNG cryogenic energy utilization in Japan; current status and prospect of the involvement of LNG bases with their neighboring industries and communities; technological measures for cryogenic energy utilization; technological measures related to low-temperature media and cold heat transportation systems; technological measures for the cascade-wise multidirectional utilization of cryogenic energy; and case studies on assumed local models. (NEDO)

Clinical Relevance and Predictive Value of Damage Biomarkers of Drug-Induced Kidney Injury.

Science.gov (United States)

Kane-Gill, Sandra L; Smithburger, Pamela L; Kashani, Kianoush; Kellum, John A; Frazee, Erin

2017-11-01

Nephrotoxin exposure accounts for up to one-fourth of acute kidney injury episodes in hospitalized patients, and the associated consequences are as severe as acute kidney injury due to other etiologies. As the use of nephrotoxic agents represents one of the few modifiable risk factors for acute kidney injury, clinicians must be able to identify patients at high risk for drug-induced kidney injury rapidly. Recently, significant advancements have been made in the field of biomarker utilization for the prediction and detection of acute kidney injury. Such biomarkers may have a role both for detection of drug-induced kidney disease and implementation of preventative and therapeutic strategies designed to mitigate injury. In this article, basic principles of renal biomarker use in practice are summarized, and the existing evidence for six markers specifically used to detect drug-induced kidney injury are outlined, including liver-type fatty acid binding protein, neutrophil gelatinase-associated lipocalin, tissue inhibitor of metalloproteinase-2 times insulin-like growth factor-binding protein 7 ([TIMP-2]·[IGFBP7]), kidney injury molecule-1 and N-acetyl-β-D-glucosaminidase. The results of the literature search for these six kidney damage biomarkers identified 29 unique articles with none detected for liver-type fatty acid binding protein and [TIMP-2]·[IGFBP7]. For three biomarkers, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and N-acetyl-β-D-glucosaminidase, the majority of the studies suggest utility in clinical practice. While many questions need to be answered to clearly articulate the use of biomarkers to predict drug-induced kidney disease, current data are promising.

Fire injury reduces inducible defenses of lodgepole pine against Mountain pine beetle.

Science.gov (United States)

Powell, Erinn N; Raffa, Kenneth F

2011-11-01

We examined the effect of wildfire injury on lodgepole pine chemical defenses against mountain pine beetle. We compared the constitutive phloem chemistry among uninjured, lightly-, moderately-, and severely-injured trees, and the induced chemistry elicited by simulated beetle attack, among these same categories. We also compared the entry rates of caged female beetles into trees of these categories. The volatiles we studied included thirteen monoterpene hydrocarbons, four allylic monoterpene alcohols, one ester, and one phenyl propanoid, of which the monoterpene hydrocarbons always comprised 96% or more of the total. Fire injury reduced the total concentration of these compounds in the induced but not constitutive phloem tissue of lodgepole pines. Fire injury also affected the relative composition of some volatiles in both induced and constitutive phloem. For example, increased fire injury reduced 4-allylanisole, a host compound that inhibits mountain pine beetle aggregation. Increased fire injury also increased (-) α-pinene, which can serve as precursor of pheromone communication. However, it also reduced myrcene and terpinolene, which can serve as stimulants and synergists of pheromone communication. Beetle entry did not show statistical differences among fire injury categories, although there was a trend to increased entry with fire injury. These results suggest that the reduced ability of trees to mobilize induced chemical defenses is an important mechanism behind the higher incidence of attack on fire-injured trees in the field. Future studies should concentrate on whether beetles that enter fire-injured trees are more likely to elicit aggregation, based on the differences we observed in volatile composition.

Amiodarone-Induced Liver Injury and Cirrhosis.

Science.gov (United States)

Buggey, Jonathan; Kappus, Matthew; Lagoo, Anand S; Brady, Carla W

2015-01-01

We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.

[Role of melatonin in calcium overload-induced heart injury].

Science.gov (United States)

Kong, Lingheng; Wei, Ming; Sun, Na; Zhu, Juanxia; Su, Xingli

2017-06-28

To investigate the role of melatonin in calcium overload-induced heart injury.
 Methods: Thirty-two rats were divided into 4 groups: a control group (Control), a melatonin control group (Mel), a calcium overload group (CaP), and a calcium overload plus melatonin group (Mel+CaP). Isolated Sprague Dawley male rat hearts underwent Langendorff perfusion. Left ventricular developed pressure (LVDP) was calculated to evaluate the myocardial performance. Triphenyltetrazolium chloride staining was used to measure the infarct size of myocardium. Lactate dehydrogenase (LDH) activity in the coronary flow was determined. The expressions of caspase-3 and cytochrome c were determined by Western blot. The pathological morphological changes in myocardial fiber were analyzed by HE staining.
 Results: Compared with the control group, calcium overload significantly induced an enlarged infarct size (Poverload-induced heart injury.

Signal Transduction Pathways Involved in Brain Death-Induced Renal Injury

NARCIS (Netherlands)

Bouma, H. R.; Ploeg, R. J.; Schuurs, T. A.

Kidneys derived from brain death organ donors show an inferior survival when compared to kidneys derived from living donors. Brain death is known to induce organ injury by evoking an inflammatory response in the donor. Neuronal injury triggers an inflammatory response in the brain, leading to

[Expression of various matrix metalloproteinases in mice with hyperoxia-induced acute lung injury].

Science.gov (United States)

Zhang, Xiang-feng; Ding, Shao-fang; Gao, Yuan-ming; Liang, Ying; Foda, Hussein D

2006-08-01

To investigate the role of matrix metalloproteinases (MMPs) and extracellular matrix metalloproteinase inducer (EMMPRIN) in the pathogenesis of acute lung injury induced by hyperoxia. Fifty four mice were exposed in sealed cages to >98% oxygen (for 24-72 hours), and another 18 mice to room air. The severity of lung injury was assessed, and the expression of mRNA and protein of MMP-2, MMP-9 and EMMPRIN in lung tissue, after exposure for 24, 48 and 72 hours of hyperoxia were studied by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Hyperoxia caused acute lung injury; this was accompanied by increased expression of an upregulation of MMP-2, MMP-9 and EMMPRIN mRNA and protein in lung tissues. Hyperoxia causes acute lung injury in mice; increases in MMP-2, MMP-9 and EMMPRIN may play an important role in the development of hyperoxia induced lung injury in mice.

Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury

Directory of Open Access Journals (Sweden)

Costello Joseph F

2008-07-01

Full Text Available Abstract Background Hypertonic saline (HTS reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung injury is not known. We investigated the potential for hypertonic saline to modulate the evolution and resolution of oleic acid induced lung injury. Methods Adult male Sprague Dawley rats were used in all experiments. Series 1 examined the potential for HTS to reduce the severity of evolving oleic acid (OA induced acute lung injury. Following intravenous OA administration, animals were randomized to receive isotonic (Control, n = 12 or hypertonic saline (HTS, n = 12, and the extent of lung injury assessed after 6 hours. Series 2 examined the potential for HTS to enhance the resolution of oleic acid (OA induced acute lung injury. Following intravenous OA administration, animals were randomized to receive isotonic (Control, n = 6 or hypertonic saline (HTS, n = 6, and the extent of lung injury assessed after 6 hours. Results In Series I, HTS significantly reduced bronchoalveolar lavage (BAL neutrophil count compared to Control [61.5 ± 9.08 versus 102.6 ± 11.89 × 103 cells.ml-1]. However, there were no between group differences with regard to: A-a O2 gradient [11.9 ± 0.5 vs. 12.0 ± 0.5 KPa]; arterial PO2; static lung compliance, or histologic injury. In contrast, in Series 2, hypertonic saline significantly reduced histologic injury and reduced BAL neutrophil count [24.5 ± 5.9 versus 46.8 ± 4.4 × 103 cells.ml-1], and interleukin-6 levels [681.9 ± 190.4 versus 1365.7 ± 246.8 pg.ml-1]. Conclusion These findings demonstrate, for the first time, the potential for HTS to reduce pulmonary inflammation and enhance the resolution of oleic acid induced lung injury.

Project risk perspective on using LNG, CNG, and GTL concepts to monetise offshore stranded gas

Energy Technology Data Exchange (ETDEWEB)

Danielsen, Hans Kristian; Blikom, Lars Petter

2010-09-15

This paper discusses technology maturity and the key risks involved in establishing LNG, CNG, and GTL value chains in order to monetise offshore stranded and associated gas. The paper uses Monte Carlo simulations to evaluate the economics of the various concepts and the impact of uncertainty. The conclusion is that LNG offers the most flexible value chain with the lowest level of risk exposure. CNG may offer better economics as long as the distance to market is fairly short. GTL must overcome significant technological challenges before becoming available for offshore use and also offers higher uncertainty in economic terms.

Brazil's insertion in the international LNG (Liquefied Natural Gas) route; A insercao do Brasil na rota internacional de GNL (Gas Natural Liquefeito)

Energy Technology Data Exchange (ETDEWEB)

Kueng, Stephan de Carvalho; Bastos, Filipe Sant' Ana [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil)

2008-07-01

In the late 1990's, PETROBRAS began considering diversifying its energy sources. This included the possibility of importing LNG (Liquefied Natural Gas), making it one additional source for gas supply in Brazil. There is a belief that the imported LNG is the cheapest, quickest and most efficient option in terms of infrastructure compared to other transportation, such as pipelines. This will permit an increase in gas supply, given the growing demand for this energy source in the domestic market. The current international LNG trading market is adjusting itself to the world integration, where short-term (spot) agreements prevail. These agreements have many advantages, such as: lowering fixed trading costs; the possibility to diversify suppliers; minimizing gas supply risk; and facilitating import market supply adjustment. In Brazil, the main objective to import LNG is to supply natural gas (NG) to thermal plants, supplementing the hydroelectric - gas integration of the electric system. For the accomplishment of this project, it is forecasted the construction of LNG offloading terminals, together with the construction of gas distribution networks. Therefore, LNG transportation will guarantee security in supply, permit the diversification of the NG supply source and enable the increased use of NG in the Brazilian energy grid. (author)

The dependencies for determining the cargo capacity of lng carriers with spherical tanks and membrane tanks at the initial stages of design

OpenAIRE

Xinshuo, Dong

2016-01-01

The boiling point of liquefied natural gas (LNG) reaches –163 °c, it means that it is necessary to use the special cargo tanks for the LNG carriers to ensure the safety of transport. In this article, the general classification of the cargo system in the LNG carriers at the first time of their operation is demonstrated. And the author summarizes the process of development of the two most common type of cargo tanks: the spherical Moss types and the membrane types. Moreover, the cargo capacity a...

Characteristics of laser-induced shock wave injury to the inner ear of rats

Science.gov (United States)

Kurioka, Takaomi; Matsunobu, Takeshi; Niwa, Katsuki; Tamura, Atsushi; Kawauchi, Satoko; Satoh, Yasushi; Sato, Shunichi; Shiotani, Akihiro

2014-12-01

Recently, the number of blast injuries of the inner ear has increased in the general population. In blast-induced inner ear injury, a shock wave (SW) component in the blast wave is considered to play an important role in sensorineural hearing loss. However, the mechanisms by which an SW affects inner ear tissue remain largely unknown. We aimed to establish a new animal model for SW-induced inner ear injury by using laser-induced SWs (LISWs) on rats. The LISWs were generated by irradiating an elastic laser target with 694-nm nanosecond pulses of a ruby laser. After LISW application to the cochlea through bone conduction, auditory measurements revealed the presence of inner ear dysfunction, the extent of which depended on LISW overpressure. A significantly lower survival rate of hair cells and spiral ganglion neurons, as well as severe oxidative damage, were observed in the inner ear exposed to an LISW. Although considerable differences in the pressure characteristics exist between LISWs and SWs in real blast waves, the functional and morphological changes shown by the present LISW-based model were similar to those observed in real blast-induced injury. Thus, our animal model is expected to be useful for laboratory-based research of blast-induced inner ear injury.

Characteristics of laser-induced shock wave injury to the inner ear of rats.

Science.gov (United States)

Kurioka, Takaomi; Matsunobu, Takeshi; Niwa, Katsuki; Tamura, Atsushi; Kawauchi, Satoko; Satoh, Yasushi; Sato, Shunichi; Shiotani, Akihiro

2014-12-01

Recently, the number of blast injuries of the inner ear has increased in the general population. In blast-induced inner ear injury, a shock wave (SW) component in the blast wave is considered to play an important role in sensorineural hearing loss. However, the mechanisms by which an SW affects inner ear tissue remain largely unknown. We aimed to establish a new animal model for SW-induced inner ear injury by using laser-induced SWs (LISWs) on rats. The LISWs were generated by irradiating an elastic laser target with 694-nm nanosecond pulses of a ruby laser. After LISW application to the cochlea through bone conduction, auditory measurements revealed the presence of inner ear dysfunction, the extent of which depended on LISW overpressure. A significantly lower survival rate of hair cells and spiral ganglion neurons, as well as severe oxidative damage, were observed in the inner ear exposed to an LISW. Although considerable differences in the pressure characteristics exist between LISWs and SWs in real blast waves, the functional and morphological changes shown by the present LISW-based model were similar to those observed in real blast-induced injury. Thus, our animal model is expected to be useful for laboratory-based research of blast-induced inner ear injury.

Thermodynamic aspects of an LNG tank in fire and experimental validation

Science.gov (United States)

Hulsbosch-Dam, Corina; Atli-Veltin, Bilim; Kamperveen, Jerry; Velthuis, Han; Reinders, Johan; Spruijt, Mark; Vredeveldt, Lex

Mechanical behaviour of a Liquefied Natural Gas (LNG) tank and the thermodynamic behaviour of its containment under extreme heat load - for instance when subjected to external fire source as might occur during an accident - are extremely important when addressing safety concerns. In a scenario where external fire is present and consequent release of LNG from pressure relief valves (PRV) has occurred, escalation of the fire might occur causing difficulty for the fire response teams to approach the tank or to secure the perimeter. If the duration of the tank exposure to fire is known, the PRV opening time can be estimated based on the thermodynamic calculations. In this paper, such an accidental scenario is considered, relevant thermodynamic equations are derived and presented. Moreover, an experiment is performed with liquid nitrogen and the results are compared to the analytical ones. The analytical results match very well with the experimental observations. The resulting analytical models are suitable to be applied to other cryogenic liquids.

Thermodynamic aspects of an LNG tank in fire and experimental validation

Directory of Open Access Journals (Sweden)

Hulsbosch-Dam Corina

2017-01-01

Full Text Available Mechanical behaviour of a Liquefied Natural Gas (LNG tank and the thermodynamic behaviour of its containment under extreme heat load – for instance when subjected to external fire source as might occur during an accident - are extremely important when addressing safety concerns. In a scenario where external fire is present and consequent release of LNG from pressure relief valves (PRV has occurred, escalation of the fire might occur causing difficulty for the fire response teams to approach the tank or to secure the perimeter. If the duration of the tank exposure to fire is known, the PRV opening time can be estimated based on the thermodynamic calculations. In this paper, such an accidental scenario is considered, relevant thermodynamic equations are derived and presented. Moreover, an experiment is performed with liquid nitrogen and the results are compared to the analytical ones. The analytical results match very well with the experimental observations. The resulting analytical models are suitable to be applied to other cryogenic liquids.

What role for LNG in Europe? Outlook for supply and demand

International Nuclear Information System (INIS)

Valais, M.; Roze, J.

1992-01-01

The current development of natural gas in Europe reflects all the technical, economic, environmental or political factors that make it one of the best energy options for the future. However, the sustained expansion of its demand must cope with a decline in domestic production in most European countries, which is resulting in a sharp rise in imports. Furthermore, because of the large volumes required, traditional exporters by pipeline to European markets could progressively come up against limits in the growth of the amounts they can supply. LNG could thus play an increasing role in the European gas balance. Europe is geographically well situated in relation to potential LNG exporting countries. The abundance of the resources and the regional diversity of these countries will be an additional guarantee of the reliability of supplies. However, any new projects can be carried out only under economic conditions that are viable for the gas industry and compatible with the development of European markets

The influence of chemical composition of LNG on the supercritical heat transfer in an intermediate fluid vaporizer

Science.gov (United States)

Xu, Shuangqing; Chen, Xuedong; Fan, Zhichao; Chen, Yongdong; Nie, Defu; Wu, Qiaoguo

2018-04-01

A three-dimensional transient computational fluid dynamics (CFD) model has been established for the simulations of supercritical heat transfer of real liquefied natural gas (LNG) mixture in a single tube and a tube bundle of an intermediate fluid vaporizer (IFV). The influence of chemical composition of LNG on the thermal performance has been analyzed. The results have also been compared with those obtained from the one-dimensional steady-state calculations using the distributed parameter model (DPM). It is found that the current DPM approach can give reasonable prediction accuracy for the thermal performance in the tube bundle but unsatisfactory prediction accuracy for that in a single tube as compared with the corresponding CFD data. As benchmarked against pure methane, the vaporization of an LNG containing about 90% (mole fraction) of methane would lead to an absolute deviation of 5.5 K in the outlet NG temperature and a maximum relative deviation of 11.4% in the tube side HTC in a bundle of about 816 U tubes at the inlet pressure of 12 MPa and mass flux of 200 kg·m-2·s-1. It is concluded that the influence of LNG composition on the thermal performance should be taken into consideration in order to obtain an economic and reliable design of an IFV.

Carbonic anhydrase inhibitor attenuates ischemia-reperfusion induced acute lung injury.

Directory of Open Access Journals (Sweden)

Chou-Chin Lan

Full Text Available Ischemia-reperfusion (IR-induced acute lung injury (ALI is implicated in several clinical conditions including lung transplantation, cardiopulmonary bypass surgery, re-expansion of collapsed lung from pneumothorax or pleural effusion and etc. IR-induced ALI remains a challenge in the current treatment. Carbonic anhydrase has important physiological function and influences on transport of CO2. Some investigators suggest that CO2 influences lung injury. Therefore, carbonic anhydrase should have the role in ALI. This study was undertaken to define the effect of a carbonic anhydrase inhibitor, acetazolamide (AZA, in IR-induced ALI, that was conducted in a rat model of isolated-perfused lung with 30 minutes of ischemia and 90 minutes of reperfusion. The animals were divided into six groups (n = 6 per group: sham, sham + AZA 200 mg/kg body weight (BW, IR, IR + AZA 100 mg/kg BW, IR + AZA 200 mg/kg BW and IR+ AZA 400 mg/kg BW. IR caused significant pulmonary micro-vascular hyper-permeability, pulmonary edema, pulmonary hypertension, neutrophilic sequestration, and an increase in the expression of pro-inflammatory cytokines. Increases in carbonic anhydrase expression and perfusate pCO2 levels were noted, while decreased Na-K-ATPase expression was noted after IR. Administration of 200mg/kg BW and 400mg/kg BW AZA significantly suppressed the expression of pro-inflammatory cytokines (TNF-α, IL-1, IL-6 and IL-17 and attenuated IR-induced lung injury, represented by decreases in pulmonary hyper-permeability, pulmonary edema, pulmonary hypertension and neutrophilic sequestration. AZA attenuated IR-induced lung injury, associated with decreases in carbonic anhydrase expression and pCO2 levels, as well as restoration of Na-K-ATPase expression.

1-methylmalate from camu-camu (Myrciaria dubia) suppressed D-galactosamine-induced liver injury in rats.

Science.gov (United States)

Akachi, Toshiyuki; Shiina, Yasuyuki; Kawaguchi, Takumi; Kawagishi, Hirokazu; Morita, Tatsuya; Sugiyama, Kimio

2010-01-01

To evaluate the protective effects of fruit juices against D-galactosamine (GalN)-induced liver injury, lyophilized fruit juices (total 12 kinds) were fed to rats for 7 d, and then we evoked liver injury by injecting GalN. The juice of camu-camu (Myrciaria dubia) significantly suppressed GalN-induced liver injury when the magnitude of liver injury was assessed by plasma alanine aminotransferase and aspartate aminotransferase activities, although some other juices (acerola, dragon fruit, shekwasha, and star fruit) also tended to have suppressive effects. An active compound was isolated from camu-camu juice by solvent fractionation and silica gel column chromatography. The structure was determined to be 1-methylmalate. On the other hand, malate, 1,4-dimethylmalate, citrate, and tartrate had no significant effect on GalN-induced liver injury. It is suggested that 1-methylmalate might be a rather specific compound among organic acids and their derivatives in fruit juices in suppressing GalN-induced liver injury.

Natural gas for ship propulsion in Denmark - Possibilities for using LNG and CNG on ferry and cargo routes

Energy Technology Data Exchange (ETDEWEB)

Stuer-Lauridsen, F.; Nielsen, Jesper B. (LITEHAUZ, Copenhagen (Denmark)); Odgaard, T.; Birkeland, M. (IncentivePartners, Birkeroed (Denmark)); Winter Graugaard, C.; Blikom, L.P. (DNV, Copenhagen (Denmark)); Muro-Sun, N.; Andersen, Morten; OEvlisen, F. (Ramboell Oil and Gas, Esbjerg (Denmark))

2010-07-01

The project's main task was to review logistical, technical and economic feasibility for using Liquefied Natural Gas (LNG) and Compressed Natural Gas (CNG) as fuel for ship propulsion and the supply of LNG or CNG to Danish ports from existing natural gas lines, trucks or by ship. The following key findings are related to the use of natural gas as fuel for ships in Denmark: Natural gas as propulsion fuel in ships: 1) Advantages: Provide solution to present air emission challenges 2) Barriers: Capital investments large 3) Synergies: Developments in Norway and Baltic Sea area 4) Economy: Positive case for operation for large consumers 5) Future: Develop bunkering options for short sea shipping LNG: 6) Propulsion technology in ships is mature and proven 7) Distribution network not yet developed for use in ships 8) Safety concerns are demanding but manageable 9) Can enter existing bunkering value chain CNG: 10) Well developed for land based transport, not yet for shipping 11) Distribution network for natural gas exists in Denmark 12) Safety concerns are demanding but manageable 13) No seaborne CNG value chains in operation An immediate focus on the ferry sector in Denmark will reap benefits on a relatively short time scale. For the short sea shipping sector away to promote the conversion to natural gas is to support the development of storage and bunkering facilities in main ports. Given the general expectations in the shipping community LNG will presumably be the de facto choice at least for the 5-10 years ahead and the demand for facilities and bunkers will be for LNG. (LN)

Electrophysiologic and clinico-pathologic characteristics of statin-induced muscle injury

Directory of Open Access Journals (Sweden)

Mohammed Abdulrazaq

2015-08-01

Conclusion: Atorvastatin increased average creatine kinase, suggesting, statins produce mild muscle injury even in asymptomatic subjects. Diabetic statin users were more prone to develop muscle injury than others. Muscle fiber conduction velocity evaluation is recommended as a simple and reliable test to diagnose statin-induced myopathy instead of invasive muscle biopsy.

Natural Gas and CO2 Price Variation: Impact on the Relative Cost-Efficiency of LNG and Pipelines

OpenAIRE

Øverland, Indra; Ulvestad, Marte

2012-01-01

This article develops a formal model for comparing the cost structure of the two main transport options for natural gas: liquefied natural gas (LNG) and pipelines. In particular, it evaluates how variations in the prices of natural gas and greenhouse gas emissions affect the relative cost-efficiency of these two options. Natural gas is often promoted as the most environmentally friendly of all fossil fuels, and LNG as a modern and efficient way of transporting it. Some research has been carri...

FY1995 research report on the survey of cryogenic energy utilization systems for environmentally friendly energy community project. Case studies of LNG cryogenic energy cascade-wise utilization; 1995 nendo kankyo chowagata energycommunity jigyo ni kakawaru reinetsu riyo system kento chosa hokokusho. LNG reinetsu no cascade teki riyo case study

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

Japan's import of LNG (liquefied natural gas) has increased in these 15 years from 13-million tons to 43-million tons at a high rate of 2-million tons a year. At present LNG is used only in power generation and town gas business, and its cryogenic feature which may be useful in various fields is not being utilized. In this survey, factors impeding the wider application of the cryogenic energy are investigated, methods for using the energy more widely and mechanisms required therefor are studied, and discussion is made about the feasibility of the utilization of the energy in a cascade-wise form under the environmentally friendly energy community project. Researches are conducted and the results are evaluated in a study carried out on the comprehensive utilization of LNG cryogenic energy. These researches involve the actualities and trends of LNG cryogenic energy utilization in Japan; current status and prospect of the involvement of LNG bases with their neighboring industries and communities; technological measures for cryogenic energy utilization; technological measures related to low-temperature media and cold heat transportation systems; technological measures for the cascade-wise multidirectional utilization of cryogenic energy; and case studies on assumed local models. (NEDO)

Radiation scanning aids tower diagnosis at Arun LNG plant

International Nuclear Information System (INIS)

Naklie, M.M.; Pless, L.; Gurning, T.P.; Hyasak, M.

1990-01-01

Radiation scanning has been used effectively to troubleshoot the treating towers of the Arun LNG plant in Sumatra, Indonesia. The plant is one of the world's largest such facilities. The analysis was part of an investigation aimed at increasing the capacity of the treater section of the plant. Radiation scanning is a tool which, in addition to tower differential pressure and product purity, can aid in diagnosing tower performance

Sodium hypochlorite-induced acute kidney injury

Directory of Open Access Journals (Sweden)

Brandon W Peck

2014-01-01

Full Text Available Sodium hypochlorite (bleach is commonly used as an irrigant during dental proce-dures as well as a topical antiseptic agent. Although it is generally safe when applied topically, reports of accidental injection of sodium hypochlorite into tissue have been reported. Local necrosis, pain and nerve damage have been described as a result of exposure, but sodium hypo-chlorite has never been implicated as a cause of an acute kidney injury (AKI. In this report, we describe the first case of accidental sodium hypochlorite injection into the infraorbital tissue during a dental procedure that precipitated the AKI. We speculate that oxidative species induced by sodium hypochlorite caused AKI secondary to the renal tubular injury, causing mild acute tubular necrosis.

Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram

Energy Technology Data Exchange (ETDEWEB)

Chang, Weiyuan; Chen, Jing; Schlueter, Connie F. [Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY (United States); Rando, Roy J. [Department of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University Health Sciences Center, New Orleans, LA (United States); Pathak, Yashwant V. [College of Pharmacy, University of South Florida, Tampa, FL (United States); Hoyle, Gary W., E-mail: Gary.Hoyle@louisville.edu [Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY (United States)

2012-09-01

Chlorine is a highly toxic respiratory irritant that when inhaled causes epithelial cell injury, alveolar-capillary barrier disruption, airway hyperreactivity, inflammation, and pulmonary edema. Chlorine is considered a chemical threat agent, and its release through accidental or intentional means has the potential to result in mass casualties from acute lung injury. The type 4 phosphodiesterase inhibitor rolipram was investigated as a rescue treatment for chlorine-induced lung injury. Rolipram inhibits degradation of the intracellular signaling molecule cyclic AMP. Potential beneficial effects of increased cyclic AMP levels include inhibition of pulmonary edema, inflammation, and airway hyperreactivity. Mice were exposed to chlorine (whole body exposure, 228–270 ppm for 1 h) and were treated with rolipram by intraperitoneal, intranasal, or intramuscular (either aqueous or nanoemulsion formulation) delivery starting 1 h after exposure. Rolipram administered intraperitoneally or intranasally inhibited chlorine-induced pulmonary edema. Minor or no effects were observed on lavage fluid IgM (indicative of plasma protein leakage), KC (Cxcl1, neutrophil chemoattractant), and neutrophils. All routes of administration inhibited chlorine-induced airway hyperreactivity assessed 1 day after exposure. The results of the study suggest that rolipram may be an effective rescue treatment for chlorine-induced lung injury and that both systemic and targeted administration to the respiratory tract were effective routes of delivery. -- Highlights: ► Chlorine causes lung injury when inhaled and is considered a chemical threat agent. ► Rolipram inhibited chlorine-induced pulmonary edema and airway hyperreactivity. ► Post-exposure rolipram treatments by both systemic and local delivery were effective. ► Rolipram shows promise as a rescue treatment for chlorine-induced lung injury.

Enhancement of the efficiency of the Open Cycle Phillips Optimized Cascade LNG process

International Nuclear Information System (INIS)

Fahmy, M.F.M.; Nabih, H.I.; El-Nigeily, M.

2016-01-01

Highlights: • Expanders replaced JT valves in the Phillips Optimized Cascade liquefaction process. • Improvement in plant liquefaction efficiency was evaluated in presence of expanders. • Comparison of the different optimum cases for the liquefaction process was presented. - Abstract: This study aims to improve the performance of the Open Cycle Phillips Optimized Cascade Process for the production of liquefied natural gas (LNG) through the replacement of Joule–Thomson (JT) valves by expanders. The expander has a higher thermodynamic efficiency than the JT valve. Moreover, the produced shaft power from the expander is integrated into the process. The study is conducted using the Aspen HYSYS-V7 simulation software for simulation of the Open Cycle Phillips Optimized Cascade Process having the JT valves. Simulation of several proposed cases in which expanders are used instead of JT valves at different locations in the process as at the propane cycle, ethylene cycle, methane cycle and the upstream of the heavies removal column is conducted. The optimum cases clearly indicate that expanders not only produce power, but also offer significant improvements in the process performance as shown by the total plant power consumption, LNG production, thermal efficiency, plant specific power and CO_2 emissions reduction. Results also reveal that replacing JT valves by expanders in the methane cycle has a dominating influence on all performance criteria and hence, can be considered as the main key contributor affecting the Phillips Optimized Cascade Process leading to a notable enhancement in its efficiency. This replacement of JT valves by liquid expanders at different locations of the methane cycle encounters power savings in the range of 4.92–5.72%, plant thermal efficiency of 92.64–92.97% and an increase in LNG production of 5.77–7.04%. Moreover, applying liquid expanders at the determined optimum cases for the different cycles, improves process performance and

Developing better mouse models to study cisplatin-induced kidney injury.

Science.gov (United States)

Sharp, Cierra N; Siskind, Leah J

2017-10-01

Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). Unfortunately, there are no therapeutic interventions for the treatment of AKI. It has been suggested that the lack of therapies is due in part to the fact that the established mouse model used to study cisplatin-induced AKI does not recapitulate the cisplatin dosing regimen patients receive. In recent years, work has been done to develop more clinically relevant models of cisplatin-induced kidney injury, with much work focusing on incorporation of multiple low doses of cisplatin administered over a period of weeks. These models can be used to recapitulate the development of CKD after AKI and, by doing so, increase the likelihood of identifying novel therapeutic targets for the treatment of cisplatin-induced kidney injury. Copyright © 2017 the American Physiological Society.

Pre-commissioning, commissioning, start-up and operation of a major extension to an LNG manufacturing facility in Bintulu, Sarawak

International Nuclear Information System (INIS)

Wong, T.

1997-01-01

In 1989, a decision was taken by the Shareholders of Malaysia LNG Sdn Bhd (MLNG) to expand their existing LNG manufacturing facility of some 8.0 million tonnes per annum, and to minimise the capital investment by maximizing the use of available off-plot facilities and utilities, together with the introduction of proven technological enhancements. Accordingly a new Company (MLNG Dua) was set up to own and manage this project and joint venture between existing shareholders. This paper describes the organisation, planning, and execution of the precommissioning, commissioning, start-up, and operation of the off-plot facilities, integrated utilities, and the first new process module, such that on-grade LNG rundown into MLNG's existing storage capacity was achieved within 26 days of the process module being signed off as Ready for Start-up (RFSU). (au)

Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury.

Directory of Open Access Journals (Sweden)

Srabani Mitra

Full Text Available Lung endothelial cell apoptosis and injury occurs throughout all stages of acute lung injury (ALI/ARDS and impacts disease progression. Lung endothelial injury has traditionally been focused on the role of neutrophil trafficking to lung vascular integrin receptors induced by proinflammatory cytokine expression. Although much is known about the pathogenesis of cell injury and death in ALI/ARDS, gaps remain in our knowledge; as a result of which there is currently no effective pharmacologic therapy. Enzymes known as caspases are essential for completion of the apoptotic program and secretion of pro-inflammatory cytokines. We hypothesized that caspase-1 may serve as a key regulator of human pulmonary microvascular endothelial cell (HPMVEC apoptosis in ALI/ARDS. Our recent experiments confirm that microparticles released from stimulated monocytic cells (THP1 induce lung endothelial cell apoptosis. Microparticles pretreated with the caspase-1 inhibitor, YVAD, or pan-caspase inhibitor, ZVAD, were unable to induce cell death of HPMVEC, suggesting the role of caspase-1 or its substrate in the induction of HPMVEC cell death. Neither un-induced microparticles (control nor direct treatment with LPS induced apoptosis of HPMVEC. Further experiments showed that caspase-1 uptake into HPMVEC and the induction of HPMVEC apoptosis was facilitated by caspase-1 interactions with microparticulate vesicles. Altering vesicle integrity completely abrogated apoptosis of HPMVEC suggesting an encapsulation requirement for target cell uptake of active caspase-1. Taken together, we confirm that microparticle centered caspase-1 can play a regulator role in endothelial cell injury.

Radiation-induced brain injury: A review

Energy Technology Data Exchange (ETDEWEB)

Greene-Schloesser, Dana; Robbins, Mike E.; Peiffer, Ann M.; Shaw, Edward G. [Department of Radiation Oncology, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Brain Tumor Center of Excellence, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Wheeler, Kenneth T. [Brain Tumor Center of Excellence, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Department of Radiology, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Chan, Michael D., E-mail: mrobbins@wakehealth.edu [Department of Radiation Oncology, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Brain Tumor Center of Excellence, Wake Forest School of Medicine,, Winston-Salem, NC (United States)

2012-07-19

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (>6 months) to experience radiation-induced brain injury. Prior to 1970, the human brain was thought to be highly radioresistant; the acute CNS syndrome occurs after single doses >30 Gy; white matter necrosis occurs at fractionated doses >60 Gy. Although white matter necrosis is uncommon with modern techniques, functional deficits, including progressive impairments in memory, attention, and executive function have become important, because they have profound effects on quality of life. Preclinical studies have provided valuable insights into the pathogenesis of radiation-induced cognitive impairment. Given its central role in memory and neurogenesis, the majority of these studies have focused on the hippocampus. Irradiating pediatric and young adult rodent brains leads to several hippocampal changes including neuroinflammation and a marked reduction in neurogenesis. These data have been interpreted to suggest that shielding the hippocampus will prevent clinical radiation-induced cognitive impairment. However, this interpretation may be overly simplistic. Studies using older rodents, that more closely match the adult human brain tumor population, indicate that, unlike pediatric and young adult rats, older rats fail to show a radiation-induced decrease in neurogenesis or a loss of mature neurons. Nevertheless, older rats still exhibit cognitive impairment. This occurs in the absence of demyelination and/or white matter necrosis similar to what is observed clinically, suggesting that more subtle molecular, cellular and/or microanatomic modifications are involved in this radiation-induced brain injury. Given that radiation-induced cognitive impairment likely reflects damage to both hippocampal- and non-hippocampal-dependent domains, there is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their

Radiation-induced brain injury: A review

International Nuclear Information System (INIS)

Greene-Schloesser, Dana; Robbins, Mike E.; Peiffer, Ann M.; Shaw, Edward G.; Wheeler, Kenneth T.; Chan, Michael D.

2012-01-01

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (>6 months) to experience radiation-induced brain injury. Prior to 1970, the human brain was thought to be highly radioresistant; the acute CNS syndrome occurs after single doses >30 Gy; white matter necrosis occurs at fractionated doses >60 Gy. Although white matter necrosis is uncommon with modern techniques, functional deficits, including progressive impairments in memory, attention, and executive function have become important, because they have profound effects on quality of life. Preclinical studies have provided valuable insights into the pathogenesis of radiation-induced cognitive impairment. Given its central role in memory and neurogenesis, the majority of these studies have focused on the hippocampus. Irradiating pediatric and young adult rodent brains leads to several hippocampal changes including neuroinflammation and a marked reduction in neurogenesis. These data have been interpreted to suggest that shielding the hippocampus will prevent clinical radiation-induced cognitive impairment. However, this interpretation may be overly simplistic. Studies using older rodents, that more closely match the adult human brain tumor population, indicate that, unlike pediatric and young adult rats, older rats fail to show a radiation-induced decrease in neurogenesis or a loss of mature neurons. Nevertheless, older rats still exhibit cognitive impairment. This occurs in the absence of demyelination and/or white matter necrosis similar to what is observed clinically, suggesting that more subtle molecular, cellular and/or microanatomic modifications are involved in this radiation-induced brain injury. Given that radiation-induced cognitive impairment likely reflects damage to both hippocampal- and non-hippocampal-dependent domains, there is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their

Time Window Is Important for Adenosine Preventing Cold-induced Injury to the Endothelium.

Science.gov (United States)

Li, Yan; Hu, Xiao-Xia; Fu, Li; Chen, Jing; Lu, Li-He; Liu, Xiang; Xu, Zhe; Zhou, Li; Wang, Zhi-Ping; Zhang, Xi; Ou, Zhi-Jun; Ou, Jing-Song

2017-06-01

Cold cardioplegia is used to induce heart arrest during cardiac surgery. However, endothelial function may be compromised after this procedure. Accordingly, interventions such as adenosine, that mimic the effects of preconditioning, may minimize endothelial injury. Herein, we investigated whether adenosine prevents cold-induced injury to the endothelium. Cultured human cardiac microvascular endothelial cells were treated with adenosine for different durations. Phosphorylation and expression of endothelial nitric oxide synthase (eNOS), p38MAPK, ERK1/2, and p70S6K6 were measured along with nitric oxide (NO) production using diaminofluorescein-2 diacetate (DAF-2DA) probe. Cold-induced injury by hypothermia to 4°C for 45 minutes to mimic conditions of cold cardioplegia during open heart surgery was induced in human cardiac microvascular endothelial cells. Under basal conditions, adenosine stimulated NO production, eNOS phosphorylation at serine 1177 from 5 minutes to 4 hours and inhibited eNOS phosphorylation at threonine 495 from 5 minutes to 6 hours, but increased phosphorylation of ERK1/2, p38MAPK, and p70S6K only after exposure for 5 minutes. Cold-induced injury inhibited NO production and the phosphorylation of the different enzymes. Importantly, adenosine prevented these effects of hypothermic injury. Our data demonstrated that adenosine prevents hypothermic injury to the endothelium by activating ERK1/2, eNOS, p70S6K, and p38MAPK signaling pathways at early time points. These findings also indicated that 5 minutes after administration of adenosine or release of adenosine is an important time window for cardioprotection during cardiac surgery.

Blueberry Anthocyanins-Enriched Extracts Attenuate Cyclophosphamide-Induced Cardiac Injury.

Directory of Open Access Journals (Sweden)

Yunen Liu

Full Text Available We sought to explore the effect of blueberry anthocyanins-enriched extracts (BAE on cyclophosphamide (CTX-induced cardiac injury. The rats were divided randomly into five groups including normal control, CTX 100 mg/kg, BAE 80mg/kg, CTX+BAE 20mg/kg and CTX+BAE 80mg/kg groups. The rats in the three BAE-treated groups were administered BAE for four weeks. Seven days after BAE administration, rats in CTX group and two BAE-treated groups were intraperitoneally injected with a single dose of 100 mg/kg CTX. Cardiac injury was assessed using physiological parameters, Echo, morphological staining, real-time PCR and western blot. In addition, cardiotoxicity indices, inflammatory cytokines expression and oxidative stress markers were also detected. Four weeks 20mg/kg and 80mg/kg dose of BAE treatment following CTX exposure attenuated mean arterial blood pressure, heart rate and activities of heart enzymes, improved cardiac dysfunction, left ventricular hypertrophy and fibrosis. Importantly, BAE also attenuated CTX-induced LV leukocyte infiltration and inflammatory cytokines expression, ameliorated oxidative stress as well as cardiomyocyte apoptosis. In conclusion, BAE attenuated the CTX-induced cardiac injury and the protective mechanisms were related closely to the anti-inflammatory, antioxidant and anti-inflammatory characteristics of BAE.

Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level.

Science.gov (United States)

Brommer, Benedikt; Engel, Odilo; Kopp, Marcel A; Watzlawick, Ralf; Müller, Susanne; Prüss, Harald; Chen, Yuying; DeVivo, Michael J; Finkenstaedt, Felix W; Dirnagl, Ulrich; Liebscher, Thomas; Meisel, Andreas; Schwab, Jan M

2016-03-01

Pneumonia is the leading cause of death after acute spinal cord injury and is associated with poor neurological outcome. In contrast to the current understanding, attributing enhanced infection susceptibility solely to the patient's environment and motor dysfunction, we investigate whether a secondary functional neurogenic immune deficiency (spinal cord injury-induced immune deficiency syndrome, SCI-IDS) may account for the enhanced infection susceptibility. We applied a clinically relevant model of experimental induced pneumonia to investigate whether the systemic SCI-IDS is functional sufficient to cause pneumonia dependent on spinal cord injury lesion level and investigated whether findings are mirrored in a large prospective cohort study after human spinal cord injury. In a mouse model of inducible pneumonia, high thoracic lesions that interrupt sympathetic innervation to major immune organs, but not low thoracic lesions, significantly increased bacterial load in lungs. The ability to clear the bacterial load from the lung remained preserved in sham animals. Propagated immune susceptibility depended on injury of central pre-ganglionic but not peripheral postganglionic sympathetic innervation to the spleen. Thoracic spinal cord injury level was confirmed as an independent increased risk factor of pneumonia in patients after motor complete spinal cord injury (odds ratio = 1.35, P spinal cord injury directly causes increased risk for bacterial infection in mice as well as in patients. Besides obvious motor and sensory paralysis, spinal cord injury also induces a functional SCI-IDS ('immune paralysis'), sufficient to propagate clinically relevant infection in an injury level dependent manner. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Finite Element Crash Simulations and Impact-Induced Injuries

Directory of Open Access Journals (Sweden)

Jaroslav Mackerle

1999-01-01

Full Text Available This bibliography lists references to papers, conference proceedings and theses/dissertations dealing with finite element simulations of crashes, impact-induced injuries and their protection that were published in 1980–1998. 390 citations are listed.

Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Directory of Open Access Journals (Sweden)

Tong Zhou

2017-01-01

Full Text Available Chronic excessive alcohol consumption (more than 40–80 g/day for males and more than 20–40 g/day for females could induce serious liver injury. In this study, effects of lemon juice on chronic alcohol-induced liver injury in mice were evaluated. The serum biochemical profiles and hepatic lipid peroxidation levels, triacylglycerol (TG contents, antioxidant enzyme activities, and histopathological changes were examined for evaluating the hepatoprotective effects of lemon juice in mice. In addition, the in vitro antioxidant capacities of lemon juice were determined. The results showed that lemon juice significantly inhibited alcohol-induced increase of alanine transaminase (ALT, aspartate transaminase (AST, hepatic TG, and lipid peroxidation levels in a dose-dependent manner. Histopathological changes induced by alcohol were also remarkably improved by lemon juice treatment. These findings suggest that lemon juice has protective effects on alcohol-induced liver injury in mice. The protective effects might be related to the antioxidant capacity of lemon juice because lemon juice showed in vitro antioxidant capacity.

Enhancement of energy performance in a boil-off gas re-liquefaction system of LNG carriers using ejectors

International Nuclear Information System (INIS)

Tan, Hongbo; Zhao, Qingxuan; Sun, Nannan; Li, Yanzhong

2016-01-01

Highlights: • An ejector-enhanced LNG boil-off gas (BOG) re-liquefaction system is proposed. • The new system has an improvement of 28% in COP over the existing system. • The specific energy consumption of the new system is reduced to 0.59 kW h/kg(BOG). • The power consumption of 754.1 kW is saved in the case study. - Abstract: An ejector-enhanced Liquefied Natural Gas (LNG) boil-off gas (BOG) re-liquefaction system is proposed to improve the energy efficiency of the existing system. In the new system, two ejectors are respectively used to reduce the energy loss in the expansion of the pressurized BOG and inject a part of fuel BOG into the compression system, and a recuperator is employed to recover the cold energy of the BOG exited from LNG tank. The performance improvement of the proposed system is analysed on the basis of the simulation in Aspen HYSYS. In the case of the re-liquefaction capacity of 4557.6 kg/h, the coefficient of performance (COP) and exergy efficiency can be increased by 28%, and the specific energy consumption (SEC) reduced from 0.756 to 0.59 kW h/kg(BOG) compared to the conventional BOG re-liquefaction system. Correspondingly, the power consumption of 754.1 kW is saved. This means that applying ejectors can effectively improve the energy efficiency of the existing BOG re-liquefaction system for LNG carriers.

Thermodynamic performance analysis of a combined power cycle using low grade heat source and LNG cold energy

International Nuclear Information System (INIS)

Kim, Kyoung Hoon; Kim, Kyung Chun

2014-01-01

Thermodynamic analysis of a combined cycle using a low grade heat source and LNG cold energy was carried out. The combined cycle consisted of an ammonia–water Rankine cycle with and without regeneration and a LNG Rankine cycle. A parametric study was conducted to examine the effects of the key parameters, such as ammonia mass fraction, turbine inlet pressure, condensation temperature. The effects of the ammonia mass fraction on the temperature distributions of the hot and cold streams in heat exchangers were also investigated. The characteristic diagram of the exergy efficiency and heat transfer capability was proposed to consider the system performance and expenditure of the heat exchangers simultaneously. The simulation showed that the system performance is influenced significantly by the parameters with the ammonia mass fraction having largest effect. The net work output of the ammonia–water cycle may have a peak value or increase monotonically with increasing ammonia mass fraction, which depends on turbine inlet pressure or condensation temperature. The exergy efficiency may decrease or increase or have a peak value with turbine inlet pressure depending on the ammonia mass fraction. - Highlights: • Thermodynamic analysis was performed for a combined cycle utilizing LNG cold energy. • Ammonia–water Rankine cycle and LNG Rankine cycle was combined. • A parametric study was conducted to examine the effects of the key parameters. • Characteristics of the exergy efficiency and heat transfer capability were proposed. • The system performance was influenced significantly by the ammonia mass fraction

Possible gasoline-induced chronic liver injury due to occupational malpractice in a motor mechanic: a case report

OpenAIRE

Gunathilaka, Mahesh Lakmal; Niriella, Madunil Anuk; Luke, Nathasha Vihangi; Piyarathna, Chathura Lakmal; Siriwardena, Rohan Chaminda; De Silva, Arjuna Priyadarshin; de Silva, Hithanadura Janaka

2017-01-01

Background Hydrocarbon-induced occupational liver injury is a well-known clinical entity among petroleum industry workers. There are many types of hydrocarbon exposure, with inhalation being the most common. Hydrocarbon-induced occupational liver injury is a rarely suspected and commonly missed etiological agent for liver injury. We report a case of a non-petroleum industry worker with chronic liver disease secondary to hydrocarbon-induced occupational liver injury caused by chronic low-grade...

Application of the Stirling engine driven with cryogenic exergy of LNG (liquefied natural gas) for the production of electricity

International Nuclear Information System (INIS)

Szczygieł, Ireneusz; Stanek, Wojciech; Szargut, Jan

2016-01-01

LNG (liquefied natural gas) delivered by means of sea-ships is pressurized and then regasified before its introduction to the system of pipelines. The utilization of cryogenic exergy of LNG for electricity production without combustion of any its portion is analyzed. For the conversion of LNG cryogenic exergy into electricity, the Stirling engine is proposed to be applied. The theoretical thermodynamic model of Stirling engine has been applied. This model is used to investigate the influence of pinch temperature in heat exchangers, engine compression ratio and dead volumes ratios on the thermodynamic parameters of the Stirling engine. The results of simulation represent the input data for investigations of thermodynamic performance of the proposed system. In order to evaluate the thermodynamic performance of the proposed process, an exergy analysis has been applied. The exergy efficiency and influence of design and operational parameters on exergy losses are determined for each of the proposed system configurations. The obtained results represent the background for advanced exergy-based analyses, including thermo-ecological cost. - Highlights: • Application of Stirling engine in LNG regasification. • Thermodynamic model of Stirling engine for cryogenic exergy recovery is applied. • Sensitivity analysis of operational parameters on system behaviour is applied. • Exergy analysis is conducted.

Energetic recovery from LNG gasification plant : cold energy utilization in agro-alimentary industry

International Nuclear Information System (INIS)

Messineo, A.; Panno, D.

2009-01-01

It is known how the complete gasification of liquefied natural gas (LNG) can return about 230 kWh/t of energy. Nevertheless out of 51 gasification plants in the world, only 31 of them are equipped with systems for the partial recovery of the available energy. At the moment most of these plants mainly produce electric energy; however the employment of the cold energy results very interesting, in fact, it can be recovered for agrofood transformation and conservation as well as for some loops in the cold chain. Cold energy at low temperatures requires high amounts of mechanical energy and it unavoidably increases as the required temperature diminishes. Cold energy recovery from LNG gasification would allow considerable energy and economic savings to these applications, as well as environmental benefits due to the reduction of climate-changing gas emissions. The task of this work is to assess the possibility to create around a gasification plant an industrial site for firms working on the transformation and conservation of agrofood products locally grown. The cold recovered from gasification would be distributed to those firms through an opportune liquid Co 2 network distribution capable of supplying the cold to the different facilities. A LNG gasification plant in a highly agricultural zone in Sicily would increase the worth of the agrofood production, lower transformation and conservation costs when compared to the traditional systems and bring economic and environmental benefits to the interested areas. [it

Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog.

Science.gov (United States)

Wang, Zhengguan; Li, Ruibing; Liu, Yifan; Liu, Xiaoting; Chen, Wenyan; Xu, Shumin; Guo, Yuni; Duan, Jinyang; Chen, Yihong; Wang, Chengbin

2015-05-01

The present study aimed to investigate the combined effects of puerarin with edaravone on inhalation lung injury induced by black gunpowder smog. Male Wistar rats were divided into five groups (control group, edaravone group, puerarin group, edaravone combined with puerarin group and inhalation group). The severity of pulmonary injuries was evaluated after inducing acute lung injury. Arterial blood gas, inflammatory cytokines, biochemical, parameters, cell counting, W/D weight ratio and histopathology were analyzed. Results in lung tissues, either edaravone or puerarin treatment alone showed significant protective effects against neutrophil infiltration and tissue injury, as demonstrated by myeloperoxidase activity and histopathological analysis (all pedaravone and puerarin demonstrated additive protective effects on smog-induced lung injury, compared with single treatment. Combination of edaravone and puerarin shows promise as a new treatment option for acute lung injury/acute respiratory distress syndrome patients. Copyright © 2015 Elsevier B.V. All rights reserved.

Deliberation of the French Energy Regulatory Commission of 18 January 2017 forming a decision on the tariffs for the use of regulated LNG terminals

International Nuclear Information System (INIS)

Ladoucette, Philippe de; Chauvet, Christine; Edwige, Catherine; Gassin, Helene; Sotura, Jean-Pierre

2017-01-01

The new tariffs for the use of regulated LNG terminals in Montoir-de-Bretagne (Montoir) and Fos Tonkin, which are operated by Elengy, and for the Fos Cavaou terminal, which is operated by Fosmax LNG, known as 'ATTM51', take effect on 1 April 2017 for a period of approximately four years. They were adopted after a broad consultation of stakeholders and following studies that were made public. The ATTM5 tariffs offer all stakeholders visibility on the changes to tariffs between 2017 and 2021, and provide incentive to LNG terminal operators to improve their efficiency in terms of both cost control and the service quality provided to the users of their terminals. The ATTM5 tariffs show a significant reduction compared to the ATTM4 tariffs: the decrease of the average unit tariff for the ATTM5 period is of 6.5 % for Montoir, 18.2 % for Fos Tonkin, and 18.6 % for Fos Cavaou. These decreases are mainly due to the lower return on assets. To a lesser extent, the reduced operating expenses reinforce the tariff reduction. They can be partly explained by the reduced expenditure related to the decrease in activity, and by the higher productivity achieved by Elengy and Fosmax LNG over the ATTM4 period, enabling the LNG terminal users to benefit from this. The ATTM5 tariffs introduce a change to the structure of the services offer. They create in particular a basic service, the main offer of the LNG terminal operators, which can be supplemented by the subscription to a uniform option. They extend several experimental services initiated during the ATTM4 tariff period. They increase the flexibility available to the terminal's clients on their subscriptions. Finally, they give Fosmax LNG the possibility to offer over the long-term the 10 % capacity previously restricted to the short-term subscriptions

Cooperative strategies in the LNG industry: is the rationalisation argument grounded?

International Nuclear Information System (INIS)

Massol, O.; Tchung-Ming, St.

2009-02-01

The authors are commenting the emergence of cooperative strategies between 12 LNG (liquefied natural gas) exporting countries which are part of the Gas Exporting Countries Forum (GECF). In this economic study, they more particularly examine the often evoked scenario of a cooperation only aimed at a logistic rationalisation, which has no impact of LNG prices. Using a simple static model calibrated with data from 2007, they assess the benefit of this cooperation. Numerical results suggest that, in absence of a redistribution policy, this cooperative strategy is likely not to be adopted. Without any redistribution, choosing cooperation would not be rational for some exporters. The issue of sharing this collective benefit is then formulated by using concepts of the cooperative game theory. Several redistribution policies are then studied, including the Shapley value and several concepts based on the nucleolus. The results reveal a relatively restrained choice for the redistribution policy. Among the used methods, only the 'per capita nucleolus', a rather sophisticated one, matches the both desirable properties: to belong to the cooperative game core and a monotony with respect to the aggregate

LNG in the next decade the changing face of the industry

Energy Technology Data Exchange (ETDEWEB)

Houston, M. [BG International (United Kingdom); Morin, P.; Laupretre, J.M. [Elf Aquitaine, Dir. du Gaz Naturel, 92 - Courbevoie (France)

2000-07-01

This paper considers the changes in the LNG industry over the past five years, and looks at how the industry might evolve by 2010.The current shape of the industry is a product of recent changes in cost structures, contracting issues, shipping and the emergence of new suppliers and new markets. In describing the possible evolution of the industry over the coming decade, two contrasting scenarios have been considered, for each of two regions of the world. The first scenario is entitled 'Continuity', and envisages that buyers and sellers will not materially change their approach towards LNG projects, in spite of the new business environment. The second scenario, entitled 'New Approach', foresees innovative solutions to technical, commercial and financial questions, in all parts of the value chain. The two world regions covered are the Atlantic - Mediterranean Basin and the Pacific-India Rim. The paper concludes that the industry is at a crossroads and that much will depend upon buyers and sellers dividing up risk in an acceptable way to meet the market and competitive challenges. (authors)

DNaseI Protects against Paraquat-Induced Acute Lung Injury and Pulmonary Fibrosis Mediated by Mitochondrial DNA

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Guo Li

2015-01-01

Full Text Available Background. Paraquat (PQ poisoning is a lethal toxicological challenge that served as a disease model of acute lung injury and pulmonary fibrosis, but the mechanism is undetermined and no effective treatment has been discovered. Methods and Findings. We demonstrated that PQ injures mitochondria and leads to mtDNA release. The mtDNA mediated PBMC recruitment and stimulated the alveolar epithelial cell production of TGF-β1 in vitro. The levels of mtDNA in circulation and bronchial alveolar lavage fluid (BALF were elevated in a mouse of PQ-induced lung injury. DNaseI could protect PQ-induced lung injury and significantly improved survival. Acute lung injury markers, such as TNFα, IL-1β, and IL-6, and marker of fibrosis, collagen I, were downregulated in parallel with the elimination of mtDNA by DNaseI. These data indicate a possible mechanism for PQ-induced, mtDNA-mediated lung injury, which may be shared by other causes of lung injury, as suggested by the same protective effect of DNaseI in bleomycin-induced lung injury model. Interestingly, increased mtDNA in the BALF of patients with amyopathic dermatomyositis-interstitial lung disease can be appreciated. Conclusions. DNaseI targeting mtDNA may be a promising approach for the treatment of PQ-induced acute lung injury and pulmonary fibrosis that merits fast tracking through clinical trials.

Gas and LNG pricing and trading hub in East Asia: An introduction

Directory of Open Access Journals (Sweden)

Xunpeng Shi

2016-10-01

Full Text Available This paper summarizes the four papers in the special issues on ‘Gas and LNG pricing and trading hub in East Asia’. The papers examine lessons and experience from European hub development, other commodity, the Japanese history on developing of futures markets and inter-fuel substitution in East Asia. The papers finds that liquid futures market is the key to formulate benchmark prices while a well-developed spot market is the foundation; political will and strong leadership are required to overcome the power of incumbents and to restructure the gas market that impede the the development of competitive markets; and East Asia needs to develop its indigenous gas or LNG trading hubs even in low oil prices period and its developing market allows easier changes in new contracts than in existing ones. This hub development requires governments to go through tough domestic market reforms, including liberalization and cooperation with each other and with gas exporters.

Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury

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Jin Wu

2015-01-01

Full Text Available Objective: The objective was to evaluate the protective effects of dexmedetomidine (DEX, a selective agonist of α2-adrenergic receptor, on sepsis-induced diaphragm injury and the underlying molecular mechanisms. Data Sources: The data used in this review were mainly from PubMed articles published in English from 1990 to 2015. Study Selection: Clinical or basic research articles were selected mainly according to their level of relevance to this topic. Results: Sepsis could induce severe diaphragm dysfunction and exacerbate respiratory weakness. The mechanism of sepsis-induced diaphragm injury includes the increased inflammatory cytokines and excessive oxidative stress and superfluous production of nitric oxide (NO. DEX can reduce inflammatory cytokines, inhibit nuclear factor-kappaB signaling pathways, suppress the activation of caspase-3, furthermore decrease oxidative stress and inhibit NO synthase. On the basis of these mechanisms, DEX may result in a shorter period of mechanical ventilation in septic patients in clinical practice. Conclusions: Based on this current available evidence, DEX may produce extra protective effects on sepsis-induced diaphragm injury. Further direct evidence and more specific studies are still required to confirm these beneficial effects.

Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation

Energy Technology Data Exchange (ETDEWEB)

Hoyle, Gary W., E-mail: Gary.Hoyle@louisville.edu [Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY (United States); Chen, Jing; Schlueter, Connie F.; Mo, Yiqun; Humphrey, David M. [Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY (United States); Rawson, Greg; Niño, Joe A.; Carson, Kenneth H. [Microencapsulation and Nanomaterials Department, Chemistry and Chemical Engineering Division, Southwest Research Institute, San Antonio, TX (United States)

2016-05-01

Chlorine is a commonly used, reactive compound to which humans can be exposed via accidental or intentional release resulting in acute lung injury. Formulations of rolipram (a phosphodiesterase inhibitor), triptolide (a natural plant product with anti-inflammatory properties), and budesonide (a corticosteroid), either neat or in conjunction with poly(lactic:glycolic acid) (PLGA), were developed for treatment of chlorine-induced acute lung injury by intramuscular injection. Formulations were produced by spray-drying, which generated generally spherical microparticles that were suitable for intramuscular injection. Multiple parameters were varied to produce formulations with a wide range of in vitro release kinetics. Testing of selected formulations in chlorine-exposed mice demonstrated efficacy against key aspects of acute lung injury. The results show the feasibility of developing microencapsulated formulations that could be used to treat chlorine-induced acute lung injury by intramuscular injection, which represents a preferred route of administration in a mass casualty situation. - Highlights: • Chlorine causes lung injury when inhaled and is considered a chemical threat agent. • Countermeasures for treatment of chlorine-induced acute lung injury are needed. • Formulations containing rolipram, triptolide, or budesonide were produced. • Formulations with a wide range of release properties were developed. • Countermeasure formulations inhibited chlorine-induced lung injury in mice.

Long-term contracts for European gas supply - an empirical analysis of the changing nature of pipeline and LNG-contracts

International Nuclear Information System (INIS)

Neumann, Anne

2005-01-01

As the structure of the European natural gas market is evolving towards more competition and more diverse market structures than before, the nature of the long-term contracts for European natural gas supply is also undergoing change. Experience from other liberalization processes, such as in the U.S. or the UK, suggests that the importance of long-term contracts diminishes over time, but that they remain an important element of supply. In Europe long-term contracts are still considered as a firm basis for investment and financing of capital-intensive infrastructure with a high degree of asset and relationship-specificity. Literature on institutional economics also suggests that long-term contracts act as a device to overcome the ''hold-up'' problem of relationship-specific investments in infrastructure (Klein, Crawford, and Alchian, 1987; Williamson, 1975, 1985). On the other hand, Hartley and Brito (2002) show that more flexible markets also imply a lower degree of asset specificity, thus requiring less fixed contracts. This paper explores the changing nature of long-term contracts for European natural gas supply, with a particular focus on differences between contracts for pipeline gas and liquefied natural gas (LNG). Traditionally, Europe relied on very long-term contracts for pipeline gas (Russia, Norway, Algeria). More recently, increasing LNG supplies are contemplated as a more flexible source of natural gas: The international LNG market is becoming more flexible, LNG can be sourced from a variety of sellers, and the cost of LNG supplies and infrastructure is coming down rapidly (Jensen, 2004). Thus, the evaluation of investing in LNG infrastructure (and the so bought flexibility and possibility of arbitraging profits) may be higher than committing to fixed/predetermined flows of pipeline gas. We ask whether this is reflected in the observed contracts. The paper is based on standard contract theory (Bolton and Dewatripont, 2005). We apply a microeconomic

MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice.

Science.gov (United States)

Song, L; Zhang, Z R; Zhang, J L; Zhu, X B; He, L; Shi, Z; Gao, L; Li, Y; Hu, B; Feng, F M

2015-10-27

Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and indices of oxidative stress during liver injury in mice after administration of isoniazid, a first-line anti-tuberculosis drug. We quantified microRNA-122 expression and indices of oxidative stress at 7 time points, including 1, 3, and 5 days and 1, 2, 3, and 4 weeks. The tissue microRNA-122 levels and oxidative stress significantly changed at 3 and 5 days, suggesting that isoniazid-induced liver injury reduces oxidative stress and microRNA-122 expression compared to in the control group (P microRNA-122, began to change at 5 days (P microRNA-122 profile may affect oxidative stress by regulating mitochondrial ribosome protein S11 gene during isoniazid-induced liver injury, which may contribute to the response mechanisms of microRNA-122 and oxidative stress.

Edaravone prevents lung injury induced by hepatic ischemia-reperfusion.

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Uchiyama, Munehito; Tojo, Kentaro; Yazawa, Takuya; Ota, Shuhei; Goto, Takahisa; Kurahashi, Kiyoyasu

2015-04-01

Lung injury is a major clinical concern after hepatic ischemia-reperfusion (I/R), due to the production of reactive oxygen species in the reperfused liver. We investigated the efficacy of edaravone, a potent free-radical scavenger, for attenuating lung injury after hepatic I/R. Adult male Sprague-Dawley rats were assigned to sham + normal saline (NS), I/R + NS, or I/R + edaravone group. Rats in the I/R groups were subjected to 90 min of partial hepatic I/R. Five minutes before reperfusion, 3 mg/kg edaravone was administered to the I/R + edaravone group. After 6 h of reperfusion, we evaluated lung histopathology and wet-to-dry ratio. We also measured malondialdehyde (MDA), an indicator of oxidative stress, in the liver and the lung, as well as cytokine messenger RNA expressions in the reperfused liver and plasma cytokine concentrations. Histopathology revealed lung damages after 6 h reperfusion of partial ischemic liver. Moreover, a significant increase in lung wet-to-dry ratio was observed. MDA concentration increased in the reperfused liver, but not in the lungs. Edaravone administration attenuated the lung injury and the increase of MDA in the reperfused liver. Edaravone also suppressed the reperfusion-induced increase of interleukin-6 messenger RNA expressions in the liver and plasma interleukin-6 concentrations. Edaravone administration before reperfusion of the ischemic liver attenuates oxidative stress in the reperfused liver and the subsequent lung injury. Edaravone may be beneficial for preventing lung injury induced by hepatic I/R. Copyright © 2015 Elsevier Inc. All rights reserved.

Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice

Energy Technology Data Exchange (ETDEWEB)

Swelm, Rachel P.L. van [Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen (Netherlands); Laarakkers, Coby M.M. [Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen (Netherlands); Pertijs, Jeanne C.L.M.; Verweij, Vivienne; Masereeuw, Rosalinde [Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen (Netherlands); Russel, Frans G.M., E-mail: F.Russel@pharmtox.umcn.nl [Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen (Netherlands)

2013-06-01

Diclofenac (DF) is a widely used non-steroidal anti-inflammatory drug for the treatment of rheumatic disorders, but is often associated with liver injury. We applied urinary proteomic profiling using MALDI-TOF MS to identify biomarkers for DF-induced hepatotoxicity in mice. Female CH3/HeOUJIco mice were treated with 75 mg/kg bw DF by oral gavage and 24 h urine was collected. Proteins identified in urine of DF-treated mice included epidermal growth factor, transthyretin, kallikrein, clusterin, fatty acid binding protein 1 and urokinase, which are related to liver regeneration but also to kidney injury. Both organs showed enhanced levels of oxidative stress (TBARS, p < 0.01). Kidney injury was confirmed by histology and increased Kim1 and Il-6 mRNA expression levels (p < 0.001 and p < 0.01). Liver histology and plasma ALT levels in DF-treated mice were not different from control, but mRNA expression of Stat3 (p < 0.001) and protein expression of PCNA (p < 0.05) were increased, indicating liver regeneration. In conclusion, urinary proteome analysis revealed that DF treatment in mice induced kidney and liver injury. Within 24 h, however, the liver was able to recover by activating tissue regeneration processes. Hence, the proteins found in urine of DF-treated mice represent kidney damage rather than hepatic injury. - Highlights: • The urinary proteome shows biological processes involved in adverse drug reactions. • Urine proteins of DF-treated mice relate to kidney injury rather than liver injury. • Liver regeneration, not liver injury, is apparent 24h after oral DF administration. • Pretreatment with LPS does not enhance DF-induced liver injury in mice.

Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses.

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Chen, Xiong; Cai, Xueding; Le, Rongrong; Zhang, Man; Gu, Xuemei; Shen, Feixia; Hong, Guangliang; Chen, Zimiao

2018-02-05

Sepsis, one of the most fatal diseases worldwide, often leads to multiple organ failure, mainly due to uncontrolled inflammatory responses. Despite accumulating knowledge obtained in recent years, effective drugs to treat sepsis in the clinic are still urgently needed. Isoliquiritigenin (ISL), a chalcone compound, has been reported to exert anti-inflammatory properties. However, little is known about the effects of ISL on sepsis and its related complications. In this study, we investigated the potential protective effects of ISL on lipopolysaccharide (LPS)-induced injuries and identified the mechanisms underlying these effects. ISL inhibited inflammatory cytokine expression in mouse primary peritoneal macrophages (MPMs) exposed to LPS. In an acute lung injury (ALI) mouse model, ISL prevented LPS-induced structural damage and inflammatory cell infiltration. Additionally, pretreatment with ISL attenuated sepsis-induced lung and liver injury, accompanied by a reduction in inflammatory responses. Moreover, these protective effects were mediated by the nuclear factor kappa B (NF-κB) pathway-mediated inhibition of inflammatory responses in vitro and in vivo. Our study suggests that ISL may be a potential therapeutic agent for sepsis-induced injuries. Copyright © 2017. Published by Elsevier Inc.

Diacylglycerol kinase regulation of protein kinase D during oxidative stress-induced intestinal cell injury

International Nuclear Information System (INIS)

Song Jun; Li Jing; Mourot, Joshua M.; Mark Evers, B.; Chung, Dai H.

2008-01-01

We recently demonstrated that protein kinase D (PKD) exerts a protective function during oxidative stress-induced intestinal epithelial cell injury; however, the exact role of DAG kinase (DGK)ζ, an isoform expressed in intestine, during this process is unknown. We sought to determine the role of DGK during oxidative stress-induced intestinal cell injury and whether DGK acts as an upstream regulator of PKD. Inhibition of DGK with R59022 compound or DGKζ siRNA transfection decreased H 2 O 2 -induced RIE-1 cell apoptosis as measured by DNA fragmentation and increased PKD phosphorylation. Overexpression of kinase-dead DGKζ also significantly increased PKD phosphorylation. Additionally, endogenous nuclear DGKζ rapidly translocated to the cytoplasm following H 2 O 2 treatment. Our findings demonstrate that DGK is involved in the regulation of oxidative stress-induced intestinal cell injury. PKD activation is induced by DGKζ, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells

Urokinase Plasminogen Activator Receptor-Deficient Mice Demonstrate Reduced Hyperoxia-Induced Lung Injury

NARCIS (Netherlands)

van Zoelen, Marieke A. D.; Florquin, Sandrine; de Beer, Regina; Pater, Jennie M.; Verstege, Marleen I.; Meijers, Joost C. M.; van der Poll, Tom

2009-01-01

Patients with respiratory failure often require supplemental oxygen therapy and mechanical ventilation. Although both supportive measures are necessary to guarantee adequate oxygen uptake, they can also cause or worsen lung inflammation and injury. Hyperoxia-induced lung injury is characterized by

Possible gasoline-induced chronic liver injury due to occupational malpractice in a motor mechanic: a case report.

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Gunathilaka, Mahesh Lakmal; Niriella, Madunil Anuk; Luke, Nathasha Vihangi; Piyarathna, Chathura Lakmal; Siriwardena, Rohan Chaminda; De Silva, Arjuna Priyadarshin; de Silva, Hithanadura Janaka

2017-07-03

Hydrocarbon-induced occupational liver injury is a well-known clinical entity among petroleum industry workers. There are many types of hydrocarbon exposure, with inhalation being the most common. Hydrocarbon-induced occupational liver injury is a rarely suspected and commonly missed etiological agent for liver injury. We report a case of a non-petroleum industry worker with chronic liver disease secondary to hydrocarbon-induced occupational liver injury caused by chronic low-grade hydrocarbon ingestion due to occupational malpractice. A 23-year-old Sri Lankan man who was a motor mechanic presented to our hospital with decompensated cirrhosis. He had been chronically exposed to gasoline via inadvertent ingestion due to occupational malpractice. He used to remove gasoline from carburetors by sucking and failed to practice mouth washing thereafter. On evaluation, he had histologically proven established cirrhosis. A comprehensive history and workup ruled out other nonoccupational etiologies for cirrhosis. The patient's long-term occupational gasoline exposure and clinical course led us to a diagnosis of hydrocarbon-induced occupational liver injury leading to decompensated cirrhosis. Hydrocarbon-induced occupational liver injury should be considered as a cause when evaluating a patient with liver injury with possible exposure in relevant occupations.

Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

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Laura A Cagle

Full Text Available Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury.To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation.5-12 week-old female BALB/c mice (n = 85 were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg or high tidal volume (15 ml/kg with or without positive end-expiratory pressure and recruitment maneuvers.Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation.Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours and lung injury worsens with longer-term ventilation (4 hrs. Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide

Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model

Science.gov (United States)

Franzi, Lisa M.; Linderholm, Angela L.; Last, Jerold A.; Adams, Jason Y.; Harper, Richart W.

2017-01-01

Background Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. Objectives To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. Methods 5–12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Results Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Conclusions Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points

Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

Science.gov (United States)

Cagle, Laura A; Franzi, Lisa M; Linderholm, Angela L; Last, Jerold A; Adams, Jason Y; Harper, Richart W; Kenyon, Nicholas J

2017-01-01

Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. 5-12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide the frequency

Working fluid selection for an Organic Rankine Cycle utilizing high and low temperature energy of an LNG engine

International Nuclear Information System (INIS)

He, Sinian; Chang, Huawei; Zhang, Xiaoqing; Shu, Shuiming; Duan, Chen

2015-01-01

This study proposed a combined Organic Rankine Cycle (ORC) system utilizing exhaust waste as its heat source and liquid natural gas (LNG) as its heat sink to provide alternative power for an LNG-fired vehicle. This system, consisting of a regenerator and a dual heat source composite heat exchanger, was designed to efficiently recover the engine waste heat (EWH) and to guarantee vaporizing LNG steadily. Five potential applicable organic working fluids are analyzed: C4F10, CF3I, R236EA, R236FA and RC318. Each fluid was analyzed at various evaporation temperatures and condensation temperatures using a thermodynamic model, and a self-made MATLAB program based on the physical properties on REFPROP data was applied to run the simulation. Analytical results showed that fluid R236FA has the highest thermal efficiency η_t_h of 21.6%, and that of the others are also around 21%. Based on a twelve-cylinder four stroke stationary natural gas engine, the simulated calculations show that the selected five working fluids can improve the fuel economy by more than 14.7% compared to that without ORC. - Highlights: • We design an ORC utilizing LNG cold energy and engine waste heat. • Five working fluids are examined at various working conditions. • The maximum thermal efficient of our proposed cycle can reach 20.3%–21.6%. • This system can decrease the brake specific fuel consumption by more than 14.7%.

LANDFILL GAS CONVERSION TO LNG AND LCO{sub 2}. PHASE 1, FINAL REPORT FOR THE PERIOD MARCH 1998-FEBRUARY 1999

Energy Technology Data Exchange (ETDEWEB)

COOK,W.J.; NEYMAN,M.; SIWAJEK,L.A.; BROWN,W.R.; VAN HAUWAERT,P.M.; CURREN,E.D.

1998-02-25

Process designs and economics were developed to produce LNG and liquid carbon dioxide (CO{sub 2}) from landfill gas (LFG) using the Acrion CO{sub 2} wash process. The patented Acrion CO{sub 2} wash process uses liquid CO{sub 2} to absorb contaminants from the LFG. The process steps are compression, drying, CO{sub 2} wash contaminant removal and CO{sub 2} recovery, residual CO{sub 2} removal and methane liquefaction. Three flowsheets were developed using different residual CO{sub 2} removal schemes. These included physical solvent absorption (methanol), membranes and molecular sieves. The capital and operating costs of the flowsheets were very similar. The LNG production cost was around ten cents per gallon. In parallel with process flowsheet development, the business aspects of an eventual commercial project have been explored. The process was found to have significant potential commercial application. The business plan effort investigated the economics of LNG transportation, fueling, vehicle conversion, and markets. The commercial value of liquid CO{sub 2} was also investigated. This Phase 1 work, March 1998 through February 1999, was funded under Brookhaven National laboratory contract 725089 under the research program entitled ``Liquefied Natural Gas as a Heavy Vehicle Fuel.'' The Phase 2 effort will develop flowsheets for the following: (1) CO{sub 2} and pipeline gas production, with the pipeline methane being liquefied at a peak shaving site, (2) sewage digester gas as an alternate feedstock to LFG and (3) the use of mixed refrigerants for process cooling. Phase 2 will also study the modification of Acrion's process demonstration unit for the production of LNG and a market site for LNG production.

The triterpenoids of Ganoderma tsugae prevent stress-induced myocardial injury in mice.

Science.gov (United States)

Kuok, Qian-Yu; Yeh, Chen-Yu; Su, Bor-Chyuan; Hsu, Pei-Ling; Ni, Hao; Liu, Ming-Yie; Mo, Fan-E

2013-10-01

Ganoderma mushrooms (Lingzhi in Chinese) have well-documented health benefits. Ganoderma tsugae (G. tsugae), one of the ganoderma species, has been commercially cultivated as a dietary supplement. Because G. tsugae has high antioxidant activity and because oxidative stress is often associated with cardiac injury, we hypothesized that G. tsugae protects against cardiac injury by alleviating oxidative stress. We tested the hypothesis using a work-overload-induced myocardial injury model created by challenging mice with isoproterenol (ISO). Remarkably, oral G. tsugae protected the mice from ISO-induced myocardial injury. Moreover, the triterpenoid fraction of G. tsugae, composed of a mixture of nine structurally related ganoderic acids (GAs), provided cardioprotection by inhibiting the ISO-induced expression of Fas/Fas ligand, oxidative stress, and apoptosis. The antioxidant activity of GAs was tested in cultured cardio-myoblast H9c2 cells against the insult of H₂O₂. GAs dissipated the cellular reactive oxygen species imposed by H₂O₂ and prevented cell death. Our findings uncovered the cardioprotective activity of G. tsugae and identified GAs as the bioactive components against cardiac insults. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Quercetin prevents pyrrolizidine alkaloid clivorine-induced liver injury in mice by elevating body defense capacity.

Directory of Open Access Journals (Sweden)

Lili Ji

Full Text Available Quercetin is a plant-derived flavonoid that is widely distributed in nature. The present study is designed to analyze the underlying mechanism in the protection of quercetin against pyrrolizidine alkaloid clivorine-induced acute liver injury in vivo. Serum transaminases, total bilirubin analysis, and liver histological evaluation demonstrated the protection of quercetin against clivorine-induced liver injury. Terminal dUTP nick end-labeling assay demonstrated that quercetin reduced the increased amount of liver apoptotic cells induced by clivorine. Western-blot analysis of caspase-3 showed that quercetin inhibited the cleaved activation of caspase-3 induced by clivorine. Results also showed that quercetin reduced the increase in liver glutathione and lipid peroxidative product malondialdehyde induced by clivorine. Quercetin reduced the enhanced liver immunohistochemical staining for 4-hydroxynonenal induced by clivorine. Results of the Mouse Stress and Toxicity PathwayFinder RT2 Profiler PCR Array demonstrated that the expression of genes related with oxidative or metabolic stress and heat shock was obviously altered after quercetin treatment. Some of the alterations were confirmed by real-time PCR. Our results demonstrated that quercetin prevents clivorine-induced acute liver injury in vivo by inhibiting apoptotic cell death and ameliorating oxidative stress injury. This protection may be caused by the elevation of the body defense capacity induced by quercetin.

Quercetin Prevents Pyrrolizidine Alkaloid Clivorine-Induced Liver Injury in Mice by Elevating Body Defense Capacity

Science.gov (United States)

Ji, Lili; Ma, Yibo; Wang, Zaiyong; Cai, Zhunxiu; Pang, Chun; Wang, Zhengtao

2014-01-01

Quercetin is a plant-derived flavonoid that is widely distributed in nature. The present study is designed to analyze the underlying mechanism in the protection of quercetin against pyrrolizidine alkaloid clivorine-induced acute liver injury in vivo. Serum transaminases, total bilirubin analysis, and liver histological evaluation demonstrated the protection of quercetin against clivorine-induced liver injury. Terminal dUTP nick end-labeling assay demonstrated that quercetin reduced the increased amount of liver apoptotic cells induced by clivorine. Western-blot analysis of caspase-3 showed that quercetin inhibited the cleaved activation of caspase-3 induced by clivorine. Results also showed that quercetin reduced the increase in liver glutathione and lipid peroxidative product malondialdehyde induced by clivorine. Quercetin reduced the enhanced liver immunohistochemical staining for 4-hydroxynonenal induced by clivorine. Results of the Mouse Stress and Toxicity PathwayFinder RT2 Profiler PCR Array demonstrated that the expression of genes related with oxidative or metabolic stress and heat shock was obviously altered after quercetin treatment. Some of the alterations were confirmed by real-time PCR. Our results demonstrated that quercetin prevents clivorine-induced acute liver injury in vivo by inhibiting apoptotic cell death and ameliorating oxidative stress injury. This protection may be caused by the elevation of the body defense capacity induced by quercetin. PMID:24905073

Angiotensin II induces calcium/calcineurin signaling and podocyte injury by downregulating microRNA-30 family members.

Science.gov (United States)

Zhao, Yue; Wu, Junnan; Zhang, Mingchao; Zhou, Minlin; Xu, Feng; Zhu, Xiaodong; Zhou, Xianguang; Lang, Yue; Yang, Fan; Yun, Shifeng; Shi, Shaolin; Liu, Zhihong

2017-08-01

Angiotensin II (AngII) is capable of inducing calcium/calcineurin signaling and podocyte injury; however, the precise underlying mechanism is not well understood. Because we have previously demonstrated that microRNA-30s (miR-30s) inhibit calcium/calcineurin signaling in podocytes, we hypothesize that AngII may induce podocyte injury by downregulating miR-30s and thereby activating calcium/calcineurin signaling. To test this hypothesis, we used an AngII-induced podocyte injury mouse model. The mice were treated with AngII via infusion for 28 days, which resulted in hypertension, albuminuria, and glomerular damage. AngII treatment also resulted in a significant reduction of miR-30s and upregulation of calcium/calcineurin signaling components, including TRPC6, PPP3CA, PPP3CB, PPP3R1, and NFATC3, which are the known targets of miR-30s in podocytes. The delivery of miR-30a-expressing lentivirus to the podocytes on day 14 of the infusion ameliorated the AngII-induced podocyte and glomerular injury and attenuated the upregulation of the calcium/calcineurin signaling components. Similarly, treatment with losartan, which is an AngII receptor blocker, also prevented AngII-induced podocyte injury and calcium/calcineurin signaling activation. Notably, losartan was found to sustain miR-30 levels during AngII treatment both in vivo and in vitro. In conclusion, the effect of AngII on podocytes is in part mediated by miR-30s through calcium/calcineurin signaling, a novel mechanism underlying AngII-induced podocyte injury. • AngII infusion resulted in downregulation of miR-30s in podocytes. • Exogenous miR-30a delivery mitigated the glomerular and podocyte injuries induced by AngII. • Both miR-30a and losartan prevented AngII-induced activation of calcium-calcineurin signaling.

Optimization control of LNG regasification plant using Model Predictive Control

Science.gov (United States)

Wahid, A.; Adicandra, F. F.

2018-03-01

Optimization of liquified natural gas (LNG) regasification plant is important to minimize costs, especially operational costs. Therefore, it is important to choose optimum LNG regasification plant design and maintaining the optimum operating conditions through the implementation of model predictive control (MPC). Optimal tuning parameter for MPC such as P (prediction horizon), M (control of the horizon) and T (sampling time) are achieved by using fine-tuning method. The optimal criterion for design is the minimum amount of energy used and for control is integral of square error (ISE). As a result, the optimum design is scheme 2 which is developed by Devold with an energy savings of 40%. To maintain the optimum conditions, required MPC with P, M and T as follows: tank storage pressure: 90, 2, 1; product pressure: 95, 2, 1; temperature vaporizer: 65, 2, 2; and temperature heater: 35, 6, 5, with ISE value at set point tracking respectively 0.99, 1792.78, 34.89 and 7.54, or improvement of control performance respectively 4.6%, 63.5%, 3.1% and 58.2% compared to PI controller performance. The energy savings that MPC controllers can make when there is a disturbance in temperature rise 1°C of sea water is 0.02 MW.

77 FR 788 - Southern LNG Company, L.L.C.; Notice of Application

Science.gov (United States)

2012-01-06

... a new 2,500 horsepower electric- driven compressor unit at its liquefied natural gas (LNG) terminal... referenced docket pursuant to section 3(a) of the Natural Gas Act (NGA) and Part 153 of the Federal Energy... to allow boil-off gas generated naturally within its storage tanks to be delivered to the downstream...

Traumatic brain injury and obesity induce persistent central insulin resistance.

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Karelina, Kate; Sarac, Benjamin; Freeman, Lindsey M; Gaier, Kristopher R; Weil, Zachary M

2016-04-01

Traumatic brain injury (TBI)-induced impairments in cerebral energy metabolism impede tissue repair and contribute to delayed functional recovery. Moreover, the transient alteration in brain glucose utilization corresponds to a period of increased vulnerability to the negative effects of a subsequent TBI. In order to better understand the factors contributing to TBI-induced central metabolic dysfunction, we examined the effect of single and repeated TBIs on brain insulin signalling. Here we show that TBI induced acute brain insulin resistance, which resolved within 7 days following a single injury but persisted until 28 days following repeated injuries. Obesity, which causes brain insulin resistance and neuroinflammation, exacerbated the consequences of TBI. Obese mice that underwent a TBI exhibited a prolonged reduction of Akt (also known as protein kinase B) signalling, exacerbated neuroinflammation (microglial activation), learning and memory deficits, and anxiety-like behaviours. Taken together, the transient changes in brain insulin sensitivity following TBI suggest a reduced capacity of the injured brain to respond to the neuroprotective and anti-inflammatory actions of insulin and Akt signalling, and thus may be a contributing factor for the damaging neuroinflammation and long-lasting deficits that occur following TBI. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Systemic progesterone for modulating electrocautery-induced secondary brain injury.

Science.gov (United States)

Un, Ka Chun; Wang, Yue Chun; Wu, Wutian; Leung, Gilberto Ka Kit

2013-09-01

Bipolar electrocautery is an effective and commonly used haemostatic technique but it may also cause iatrogenic brain trauma due to thermal injury and secondary inflammatory reactions. Progesterone has anti-inflammatory and neuroprotective actions in traumatic brain injury. However, its potential use in preventing iatrogenic brain trauma has not been explored. We conducted a pilot animal study to investigate the effect of systemic progesterone on brain cellular responses to electrocautery-induced injury. Adult male Sprague-Dawley rats received standardized bipolar electrocautery (40 W for 2 seconds) over the right cerebral cortex. The treatment group received progesterone intraperitoneally 2 hours prior to surgery; the control group received the drug vehicle only. Immunohistochemical studies showed that progesterone could significantly reduce astrocytic hypertrophy on postoperative day 1, 3 and 7, as well as macrophage infiltration on day 3. The number of astrocytes, however, was unaffected. Our findings suggest that progesterone should be further explored as a neuroprotective agent against electrocautery-induced or other forms of iatrogenic trauma during routine neurosurgical procedures. Future studies may focus on different dosing regimens, neuronal survival, functional outcome, and to compare progesterone with other agents such as dexamethasone. Copyright © 2013 Elsevier Ltd. All rights reserved.

Does sucralfate prevent apoptosis occurring in the ischemia/reperfusion-induced intestinal injury?

Science.gov (United States)

Sencan, A; Yilmaz, O; Ozer, E; Günşar, C; Genç, K; Ulukuş, C; Taneli, C; Mir, E

2003-08-01

We have shown in a previous study that sucralfate is beneficial in the prophylaxis and treatment of hypoxia/reoxygenation-induced intestinal injury. The aim of this study is to investigate whether sucralfate has any effect on the prevention of apoptosis in the ischemia/reperfusion (I/R)-induced intestinal injury. Rats were randomized into three groups. Group 1 and 2 were subjected to I/R. Group 1 (treatment group) received sucralfate while group 2 (treatment control group) did not. Group 3 served as a normal control group (sham group). The terminal ileum was harvested for histopathologic investigation by light microscopy. The presence of apoptotic enterocytes (DNA fragmentation in cell nuclei) was detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end-labeling (TUNEL) reaction. In treatment control group, 3 of 7 rats had severe inflammation. None of the sucralfate-treated rats showed severe inflammation, 6 of them only showed mild inflammatory changes (p < 0.05). The apoptotic percentage was found to be 37.1 +/- 9.4 in the sucralfate-treated group (group 1), whereas it was 45.4 +/- 3.9 in the untreated group (group 2) (p < 0.05). The sham group had a completely normal intestinal architecture. The present study shows that 1) the experimental model of I/R-induced intestinal injury induces enterocyte apoptosis; 2) sucralfate decreases enterocyte apoptosis in the experimental model of I/R-induced intestinal injury which may play a key role in the pathophysiological events leading to failure of the intrinsic gut barrier defense mechanisms.

Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration

OpenAIRE

Park, Jung Hyun; Ku, Hyeong Jun; Lee, Jin Hyup; Park, Jeen-Woo

2017-01-01

Acrolein is known to be involved in acute lung injury and other pulmonary diseases. A number of studies have suggested that acrolein-induced toxic effects are associated with depletion of antioxidants, such as reduced glutathione and protein thiols, and production of reactive oxygen species. Mitochondrial NADP+-dependent isocitrate dehydrogenase (idh2) regulates mitochondrial redox balance and reduces oxidative stress-induced cell injury via generation of NADPH. Therefore, we evaluated the ro...

Thermodynamic analysis of direct expansion configurations for electricity production by LNG cold energy recovery

International Nuclear Information System (INIS)

Franco, Alessandro; Casarosa, Claudio

2015-01-01

In the present paper, after a brief review of the perspectives of the various schemes proposed for electricity generation from the regasification of Liquefied Natural Gas (LNG), a detailed analysis of two particular direct expansion solutions is proposed. The purpose is to identify the upper level of the energy that can be recovered with the aim of electricity production, using configurations with direct expansion. The analysis developed resorting to a simplified thermodynamic model, shows that using a direct expansion configurations with multistage turbine, values of power production typical of optimized ORC plant configurations (120 kJ for each kg of natural gas that flows through the plant) can be obtained. The development of a direct expansion plant with multistage turbine and internal heat recovery systems could permit to approach the production of more than 160 kJ for each kg of flowing liquefied natural gas. Considering values of the mass flow rate typical of LNG gas stations (e.g. 70 kg/s); this corresponds to an output power ranging between 8.3 MW and 11.4 MW. - Highlights: • Recovery of the cold energy contained in Liquefied Natural Gas. • Thermodynamic analysis of systems for electricity generation in regasification. • Direct expansion solutions with multistage expansion. • Comparison of direct expansion solutions with conventional ORC systems. • Power output in conditions typical of existing LNG regasification terminals

Liver injury from Herbals and Dietary Supplements in the US Drug Induced Liver Injury Network

Science.gov (United States)

Navarro, Victor J.; Barnhart, Huiman; Bonkovsky, Herbert L.; Davern, Timothy; Fontana, Robert J.; Grant, Lafaine; Reddy, K. Rajender; Seeff, Leonard B.; Serrano, Jose; Sherker, Averell H.; Stolz, Andrew; Talwalkar, Jayant; Vega, Maricruz; Vuppalanchi, Raj

2014-01-01

Background The Drug-Induced Liver Injury Network (DILIN) studies hepatotoxicity due to conventional medications as well as herbals and dietary supplements (HDS). Rationale To characterize hepatotoxicity and its outcomes from HDS versus medications, patients with hepatotoxicity attributed to medications or HDS were enrolled prospectively between 2004 and 2013. The study took place among eight US referral centers that are part of the DILIN. Consecutive patients with liver injury referred to a DILIN center were eligible. The final sample comprised 130 (15.5%) of all subjects enrolled (839) who were judged to have experienced liver injury due to HDS. Hepatotoxicity due to HDS was evaluated by expert opinion. Demographic and clinical characteristics and outcome assessments including death and liver transplantation were ascertained. Cases were stratified and compared according to the type of agent implicated in liver injury; 45 had injury due to bodybuilding HDS, 85 due to non-bodybuilding HDS, and 709 due to medications. Main Results Liver injury due to HDS increased from 7% to 20% (p Bodybuilding HDS caused prolonged jaundice (median 91 days) in young men but did not result in any fatalities or liver transplantation. The remaining HDS cases presented as hepatocellular injury, predominantly in middle-aged women and more frequently led to death or transplantation compared to injury from medications (13% vs. 3%, p bodybuilding HDS is more severe than from bodybuilding HDS or medications, as evidenced by differences in unfavorable outcomes; death and transplantation. PMID:25043597

Mechanical injury induces brain endothelial-derived microvesicle release: Implications for cerebral vascular injury during traumatic brain injury

Directory of Open Access Journals (Sweden)

Allison M. Andrews

2016-02-01

Full Text Available It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and mechanotransduction. However, our understanding of vascular remodeling following traumatic brain injury (TBI remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produce extracellular microvesicles (eMVs, such as microparticles, in response to changes in mechanical forces (blood flow and mechanical injury. Yet, to date, no studies have shown whether brain endothelial cells produce eMVs following TBI. The brain endothelium is highly specialized and forms the blood-brain barrier (BBB, which regulates diffusion and transport of solutes into the brain. This specialization is largely due to the presence of tight junction proteins (TJPs between neighboring endothelial cells. Following TBI, a breakdown in tight junction complexes at the BBB leads to increased permeability, which greatly contributes to the secondary phase of injury. We have therefore tested the hypothesis that brain endothelium responds to mechanical injury, by producing eMVs that contain brain endothelial proteins, specifically TJPs. In our study, primary human adult brain microvascular endothelial cells (BMVEC were subjected to rapid mechanical injury to simulate the abrupt endothelial disruption that can occur in the primary injury phase of TBI. eMVs were isolated from the media following injury at 2, 6, 24 and 48 hrs. Western blot analysis of eMVs demonstrated a time-dependent increase in TJP occludin, PECAM-1 and ICAM-1 following mechanical injury. In addition, activation of ARF6, a small GTPase linked to extracellular vesicle production, was increased after injury. To confirm these results in vivo, mice were subjected to sham surgery or TBI and blood plasma was collected 24 hrs post-injury. Isolation and analysis of eMVs from blood plasma using cryo-EM and flow cytometry revealed elevated levels of vesicles containing

Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury.

Science.gov (United States)

Andrews, Allison M; Lutton, Evan M; Merkel, Steven F; Razmpour, Roshanak; Ramirez, Servio H

2016-01-01

It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produce extracellular microvesicles (eMVs), such as microparticles, in response to changes in mechanical forces (blood flow and mechanical injury). Yet, to date, no studies have shown whether brain endothelial cells produce eMVs following TBI. The brain endothelium is highly specialized and forms the blood-brain barrier (BBB), which regulates diffusion and transport of solutes into the brain. This specialization is largely due to the presence of tight junction proteins (TJPs) between neighboring endothelial cells. Following TBI, a breakdown in tight junction complexes at the BBB leads to increased permeability, which greatly contributes to the secondary phase of injury. We have therefore tested the hypothesis that brain endothelium responds to mechanical injury, by producing eMVs that contain brain endothelial proteins, specifically TJPs. In our study, primary human adult brain microvascular endothelial cells (BMVEC) were subjected to rapid mechanical injury to simulate the abrupt endothelial disruption that can occur in the primary injury phase of TBI. eMVs were isolated from the media following injury at 2, 6, 24, and 48 h. Western blot analysis of eMVs demonstrated a time-dependent increase in TJP occludin, PECAM-1 and ICAM-1 following mechanical injury. In addition, activation of ARF6, a small GTPase linked to extracellular vesicle production, was increased after injury. To confirm these results in vivo, mice were subjected to sham surgery or TBI and blood plasma was collected 24 h post-injury. Isolation and analysis of eMVs from blood plasma using cryo-EM and flow cytometry revealed elevated levels of vesicles containing occludin following brain trauma