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Sample records for ll leftmost k-linear

  1. Non-leftmost Unfolding in Partial Evaluation of Logic Programs with Impure Predicates

    DEFF Research Database (Denmark)

    Albert, Elvira; Puebla, German; Gallagher, John Patrick

    2006-01-01

    -leftmost unfolding steps can result in incorrect results since the independence of the computation rule no longer holds in the presence of impure predicates. Existing proposals allow non-leftmost unfolding steps, but at the cost of accuracy: bindings and failure are not propagated backwards to predicates which...

  2. LL-regular grammars

    NARCIS (Netherlands)

    Nijholt, Antinus

    1980-01-01

    Culik II and Cogen introduced the class of LR-regular grammars, an extension of the LR(k) grammars. In this paper we consider an analogous extension of the LL(k) grammars called the LL-regular grammars. The relation of this class of grammars to other classes of grammars will be shown. Any LL-regular

  3. The transition probability and the probability for the left-most particle's position of the q-totally asymmetric zero range process

    Energy Technology Data Exchange (ETDEWEB)

    Korhonen, Marko [Department of Mathematics and Statistics, University of Helsinki, FIN-00014 (Finland); Lee, Eunghyun [Centre de Recherches Mathématiques (CRM), Université de Montréal, Quebec H3C 3J7 (Canada)

    2014-01-15

    We treat the N-particle zero range process whose jumping rates satisfy a certain condition. This condition is required to use the Bethe ansatz and the resulting model is the q-boson model by Sasamoto and Wadati [“Exact results for one-dimensional totally asymmetric diffusion models,” J. Phys. A 31, 6057–6071 (1998)] or the q-totally asymmetric zero range process (TAZRP) by Borodin and Corwin [“Macdonald processes,” Probab. Theory Relat. Fields (to be published)]. We find the explicit formula of the transition probability of the q-TAZRP via the Bethe ansatz. By using the transition probability we find the probability distribution of the left-most particle's position at time t. To find the probability for the left-most particle's position we find a new identity corresponding to identity for the asymmetric simple exclusion process by Tracy and Widom [“Integral formulas for the asymmetric simple exclusion process,” Commun. Math. Phys. 279, 815–844 (2008)]. For the initial state that all particles occupy a single site, the probability distribution of the left-most particle's position at time t is represented by the contour integral of a determinant.

  4. LALR(1) : LL(1) = LR(0) : LL(0)

    NARCIS (Netherlands)

    Kruseman Aretz, F.E.J.; Emde Boas, van P.; Hemker, P.W.; Hoffman, W.; Houwen, van der P.J.; Pfluger, P.R.

    1992-01-01

    It is shown that LL(l) and LALR(l) acceptors can be obtained by restricting the action tables of the corresponding LL(O) and LR(O) acceptors to those entries that are accessed in at least one accepting sequence (of a sentence from the language). It follows that a number of properties that are easily

  5. Unifying LL and LR parsing

    NARCIS (Netherlands)

    W.H.L.M. Pijls (Wim)

    1993-01-01

    textabstractIn parsing theory, LL parsing and LR parsing are regarded to be two distinct methods. In this paper the relation between these methods is clarified.As shown in literature on parsing theory, for every context-free grammar, a so-called non-deterministic LR(0) automaton can be constructed.

  6. The equivalence problem for LL- and LR-regular grammars

    NARCIS (Netherlands)

    Nijholt, Antinus; Gecsec, F.

    It will be shown that the equivalence problem for LL-regular grammars is decidable. Apart from extending the known result for LL(k) grammar equivalence to LLregular grammar equivalence, we obtain an alternative proof of the decidability of LL(k) equivalence. The equivalence prob]em for LL-regular

  7. An interior-point method for the Cartesian P*(k-linear complementarity problem over symmetric cones

    Directory of Open Access Journals (Sweden)

    B Kheirfam

    2014-06-01

    Full Text Available A novel primal-dual path-following interior-point algorithm for the Cartesian P*(k-linear complementarity problem over symmetric cones is presented. The algorithm is based on a reformulation of the central path for finding the search directions. For a full Nesterov-Todd step feasible interior-point algorithm based on the new search directions, the complexity bound of the algorithm with small-update approach is the best-available bound.

  8. From LL-regular to LL(1) grammars: Transformations, covers and parsing

    NARCIS (Netherlands)

    Nijholt, Antinus

    1982-01-01

    In this paper it is shown that it is possible to transform any LL-regular grammar G into an LL(1) grammar G' in such a way that parsing G' is as good as parsing G. That is, a parse of a sentence of grammar G can be obtained with a simple string homomorphism from the parse of a corresponding sentence

  9. CAIs in Semarkona (LL3.0)

    Science.gov (United States)

    Mishra, R. K.; Simon, J. I.; Ross, D. K.; Marhas, K. K.

    2016-01-01

    Calcium, Aluminum-rich inclusions (CAIs) are the first forming solids of the Solar system. Their observed abundance, mean size, and mineralogy vary quite significantly between different groups of chondrites. These differences may reflect the dynamics and distinct cosmochemical conditions present in the region(s) of the protoplanetary disk from which each type likely accreted. Only about 11 such objects have been found in L and LL type while another 57 have been found in H type ordinary chondrites, compared to thousands in carbonaceous chondrites. At issue is whether the rare CAIs contained in ordinary chondrites truly reflect a distinct population from the inclusions commonly found in other chondrite types. Semarkona (LL3.00) (fall, 691 g) is the most pristine chondrite available in our meteorite collection. Here we report petrography and mineralogy of 3 CAIs from Semarkona

  10. 25 Years of the Lesbian Section LL

    Directory of Open Access Journals (Sweden)

    Nataša Sukič

    2013-03-01

    Full Text Available Author describes the beginnings and the history of Škuc LL, the first activist lesbian group in Eastern Europe and former Yugoslavia. Trough projects within the cultural and political domains the group has been fighting against lesbophobia and homophobia for the last 25 years. The group tries to create an inclusive, united and egalitarian society of enlightment ideals. The author mixes personal activist history with a development of a lesbian movement from the first initiative in the alternative society of the 80s in Ljubljana to the situation today.

  11. Human cathelicidin LL-37 – Does it influence the homeostatic ...

    Indian Academy of Sciences (India)

    70

    37; pulmonary tuberculosis; schizophrenia. 1. Introduction. Cathelicidins are ..... higher LL-37 levels in the cerebrospinal fluid and serum of children with ... found to be lower in cultured epidermal cells taken from biopsies of diabetic foot ulcers .... Greer A, Zenobia C and Darveau RP 2013 Defensins and LL-37: a review of ...

  12. COPD: When You Learn More, You'll Breathe Better

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues COPD: When You Learn More, You'll Breathe Better ... Trial to Look at Home Oxygen Therapy for COPD The National Heart, Lung, and Blood Institute (NHLBI) ...

  13. Holmium laser lithotripsy (HoLL) of ureteral calculi

    Science.gov (United States)

    Kuntz, Rainer M.; Lehrich, Karin; Fayad, Amr

    2001-05-01

    The effectiveness and side effects of ureteroscopic HoLL of ureteral stones should be evaluated. In 63 patients (17 female, 46 males) a total of 75 stones of 3-20 mm diameter were treated with ureteroscopic HoLL. 18.7 percent of stones were located in the proximal third, 24.0 percent in the middle third and 57.3 percent in the distal third of the ureter. HoLL was performed with small diameter semirigid and flexible ureteroscopes, 220 or 365 nm flexible laser fibers and a holmium:YAG laser at a power of 5-15 W (0.5-1.0 J, 10- 15 Hz). 47 of 63 patients (74.6 percent) were immediately free of stones, and 8 others (12.6 percent) lost their residual fragments spontaneously within two weeks. Another 2 patients received additional chmolitholysis for uric acid stone fragments, i.e. 90.5 percent of patients were stone free by one sitting of ureterscopic HoLL. Of the remaining 6 patients (9.5 percent) who still had residual calculi 4 weeks after HoLL, 2 asymptomatic patients refused any additional treatment, 2 patients preferred treatment with ESWL, and 2 patients had a successful second HoLL, thereby raising the success rate of ureteroscopic HoLL to 93.7 percent. 2 patients showed contrast medium extravasation on retrograde ureterograms, due to guide wire perforation. No ureteral stricture occurred. In conclusion, transurethral ureteroscopic HoLL proved to be a safe and successful minimal invasive treatment of ureteral calculi.

  14. llén’s constant $M$

    CERN Document Server

    Stora, Raymond

    2014-01-01

    In his Handbook Article [1] G. Källén states the asymptotic condition in quantum electrodynamics where the arrow stands for the “weak” asymptotic limit a la LSZ and M is a finite computable constant expressible in terms of the Källén-Lehmann weight function Π(a) for the photon two point function. All the time, there were conflicting points of view between Källén and LSZ, the former insisting on the canonical formulation (which is sick for coupled fields) and the latter who insist on the asymptotic condition. Amusingly enough followers of LSZ in the framework of LSZ assume [2] which turns out to be inconsistent with perturbative renormalizability. Now Källén’s asymptotic condition is perfectly compatible with LSZ since the free vector field A μ in (x) is associated with a reducible representation of the Poincaré group. The best way to sort this out is to look at massive QED (add a mass term to Källén’s Lagrangian in the Handbook Article, see below). The constant M produces in the cano...

  15. Solving L-L Extraction Problems with Excel Spreadsheet

    Science.gov (United States)

    Teppaitoon, Wittaya

    2016-01-01

    This work aims to demonstrate the use of Excel spreadsheets for solving L-L extraction problems. The key to solving the problems successfully is to be able to determine a tie line on the ternary diagram where the calculation must be carried out. This enables the reader to analyze the extraction process starting with a simple operation, the…

  16. The equivalence problem for LL- and LR-regular grammars

    NARCIS (Netherlands)

    Nijholt, Antinus

    1982-01-01

    The equivalence problem for context-free grammars is "given two arbitrary grammars, do they generate the same language?" Since this is undecidable in general, attention has been restricted to decidable subclasses of the context-free grammars. For example, the classes of LL(k) grammars and real-time

  17. Noble Gases in the Hamlet Meteorite (LL4)

    Science.gov (United States)

    Amari, S.; Sabe, Y.; Shiraishi, T.; Matsuda, J.

    2014-09-01

    We analyzed noble gases in a bulk sample and an HF-HCl residue of Hamlet (LL4). The Xe composition of the residue shows that no diamond is contained in the residue. The 20Ne/22Ne ratio of Hamlet Ne-Q has been determined to be 11.0 ± 0.5.

  18. A Case Study of I’ll Be Fine

    Directory of Open Access Journals (Sweden)

    Angela Ferraiolo

    2017-04-01

    Full Text Available This case study of I’ll Be Fine describes my creation of a passively interactive, “playable” movie for networked screens, and outlines reasons why this story is an instance of a new genre of storytelling that might be called “playable narrative”. Although the piece is interactive, and while it seems to satisfy certain features of the activity of play, I’ll Be Fine does not offer opportunities for strategy, competition, or closure, and does not proceed towards goals or outcomes, but seeks to construct meaning cinematically, proceeding sequentially across planes or layers, and using a spatial design much like the cinematic compositional scheme of background, middle ground, and foreground. While a general model for the spatial construction of playable movies is outside the scope of this writing, the following description of my design concepts are meant to delineate certain aspects of working with spatiality and playability while constructing an interactive story.

  19. Markkinointiviestintä Venäjällä

    OpenAIRE

    Rajalin, Nigina

    2014-01-01

    Tämän opinnäytetyön tavoitteena on selvittää markkinointiviestintää Venäjällä, jotta suomalaiset pienyritykset osaisivat tehokkaasti ja tuloksellisesti markkinoida itseään. Opinnäytetyössä selvitetään Venäjän markkinoiden tilannetta ja tehokkaita markkinointiviestinnän keinoja Venäjällä. Opinnäytetyössä tehdään yleiskatsaus Venäjän talouteen ja sen nykytilaan. Työssä perehdytään Venäjän kulttuuriin ja sen vaikutuksiin markkinointiviestinnässä. Työ on jaettu kahteen teoriaosaan. Ensimmäises...

  20. M4SF-17LL010301071: Thermodynamic Database Development

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Institute, Physical & Life Sciences; Wolery, T. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Akima Infrastructure Services, LLC

    2017-09-05

    This progress report (Level 4 Milestone Number M4SF-17LL010301071) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Argillite Disposal R&D Work Package Number M4SF-17LL01030107. The DR Argillite Disposal R&D control account is focused on the evaluation of important processes in the analysis of disposal design concepts and related materials for nuclear fuel disposal in clay-bearing repository media. The objectives of this work package are to develop model tools for evaluating impacts of THMC process on long-term disposal of spent fuel in argillite rocks, and to establish the scientific basis for high thermal limits. This work is contributing to the GDSA model activities to identify gaps, develop process models, provide parameter feeds and support requirements providing the capability for a robust repository performance assessment model by 2020.

  1. Gottlieb Bindesbøll and Romantic Historicism

    DEFF Research Database (Denmark)

    Kristensen, Peter Thule

    2013-01-01

    The article demonstrates how the Danish architect Gottlieb Bindesbøll (1800-1856) employed a form of repetition of motifs many places in his architecture, regardless of style. A closer look shows that this is not only a distinctive feature of a single architect's work, but also a new way...... of achieving consistency. This design principle emerged in the romantic view of architecture as an organic entity and later became influential among twentieth-century Danish architects....

  2. Stability of the cathelicidin peptide LL-37 in a non-healing wound environment

    DEFF Research Database (Denmark)

    Grönberg, Alvar; Zettergren, Louise; Ågren, Sven Per Magnus

    2011-01-01

    The endogenous cathelicidin peptide LL-37 is strongly expressed at the wound edge early in the process of acute wound healing, but only weakly expressed in chronic wounds. Excessive proteolysis may limit the therapeutic usefulness of exogenous LL-37, especially in ulcers colonized with Pseudomonas...... aeruginosa that produce elastase, which degrades LL-37. This study investigated the stability of synthetic LL-37 against two types of proteinases in the presence or absence of wound fluid samples (diluted to 10-20%) from nine non-healing venous leg ulcers. Incubation of LL-37 (10 µg/ml) at 37°C for 6 h...... resulted in complete degradation by the serine proteinase trypsin (≥ 10 ng/ml), while no degradation was observed with matrix metalloproteinase-9. LL-37 susceptibility to trypsin was diminished considerably in the presence of wound fluid, and there was no apparent cleavage of exogenous LL-37 incubated...

  3. LL-37 induces polymerization and bundling of actin and affects actin structure.

    Directory of Open Access Journals (Sweden)

    Asaf Sol

    Full Text Available Actin exists as a monomer (G-actin which can be polymerized to filaments F-actin that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton. Bundled actin from lysed cells increases the viscosity of sputum in lungs of cystic fibrosis patients. The human host defense peptide LL-37 was previously shown to induce actin bundling and was thus hypothesized to contribute to the pathogenicity of this disease. In this work, interactions between actin and the cationic LL-37 were studied by optical, proteolytic and surface plasmon resonance methods and compared to those obtained with scrambled LL-37 and with the cationic protein lysozyme. We show that LL-37 binds strongly to CaATP-G-actin while scrambled LL-37 does not. While LL-37, at superstoichiometric LL-37/actin concentrations polymerizes MgATP-G-actin, at lower non-polymerizing concentrations LL-37 inhibits actin polymerization by MgCl(2 or NaCl. LL-37 bundles Mg-F-actin filaments both at low and physiological ionic strength when in equimolar or higher concentrations than those of actin. The LL-37 induced bundles are significantly less sensitive to increase in ionic strength than those induced by scrambled LL-37 and lysozyme. LL-37 in concentrations lower than those needed for actin polymerization or bundling, accelerates cleavage of both monomer and polymer actin by subtilisin. Our results indicate that the LL-37-actin interaction is partially electrostatic and partially hydrophobic and that a specific actin binding sequence in the peptide is responsible for the hydrophobic interaction. LL-37-induced bundles, which may contribute to the accumulation of sputum in cystic fibrosis, are dissociated very efficiently by DNase-1 and also by cofilin.

  4. Resummed Higgs cross section at N3LL

    International Nuclear Information System (INIS)

    Bonvini, Marco; Marzani, Simone

    2014-05-01

    We present accurate predictions for the inclusive production of a Higgs boson in proton-proton collisions, via gluon-gluon fusion. Our calculation includes next-to-next-to-leading order (NNLO) corrections in perturbative QCD, as well as the resummation of threshold-enhanced contributions to next-to-next-to-next-to-leading logarithmic (N 3 LL) accuracy, with the inclusion of the recently-determined three-loop constant coefficient (sometimes referred to as N 3 LL' accuracy). Our result correctly accounts for finite top, bottom and charm masses at leading order (LO) and next-to-leading order (NLO), and includes the exact top mass dependence at NNLO. At the resummed level the dependence on top, bottom and charm mass is accounted for at NLL, while only the top mass at NNLL. The all-order calculation is improved by a suitable choice of the soft terms, dictated by analyticity conditions and by the inclusion of subleading corrections of collinear origin, which improve the accuracy of the resummation away from the threshold region. We present results for different collider energies and we study perturbative uncertainties by varying renormalization and factorization scales. We find that, at current LHC energies, the resummation corrects the NNLO result by as much as 20 % at μ R =μ F =m H , while the correction is much smaller, 5.5 %, at μ R =μ F =m H /2. While the central value of NNLO+N 3 LL result depends very mildly on the scale choice, we argue that a more realiable estimate of the theoretical uncertainty is found if the perturbative scales are canonically varied about m H .

  5. PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

    Science.gov (United States)

    Chereddy, Kiran Kumar; Her, Charles-Henry; Comune, Michela; Moia, Claudia; Lopes, Alessandra; Porporato, Paolo E; Vanacker, Julie; Lam, Martin C; Steinstraesser, Lars; Sonveaux, Pierre; Zhu, Huijun; Ferreira, Lino S; Vandermeulen, Gaëlle; Préat, Véronique

    2014-11-28

    Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Poly (lactic-co-glycolic acid) (PLGA) supplies lactate that accelerates neovascularization and promotes wound healing. LL37 is an endogenous human host defense peptide that modulates wound healing and angiogenesis and fights infection. Hence, we hypothesized that the administration of LL37 encapsulated in PLGA nanoparticles (PLGA-LL37 NP) promotes wound closure due to the sustained release of both LL37 and lactate. In full thickness excisional wounds, the treatment with PLGA-LL37 NP significantly accelerated wound healing compared to PLGA or LL37 administration alone. PLGA-LL37 NP-treated wounds displayed advanced granulation tissue formation by significant higher collagen deposition, re-epithelialized and neovascularized composition. PLGA-LL37 NP improved angiogenesis, significantly up-regulated IL-6 and VEGFa expression, and modulated the inflammatory wound response. In vitro, PLGA-LL37 NP induced enhanced cell migration but had no effect on the metabolism and proliferation of keratinocytes. It displayed antimicrobial activity on Escherichia coli. In conclusion, we developed a biodegradable drug delivery system that accelerated healing processes due to the combined effects of lactate and LL37 released from the nanoparticles. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. Mis saab ESTERMist? / Tiina Soon, Peeter Päll, Ivi Papstel ; interv. Aili Künstler

    Index Scriptorium Estoniae

    Soon, Tiina

    2008-01-01

    Eesti Õiguskeskuse loodud andmebaasist ESTERM. Vastavad EKI terminoloogiaosakonna juhataja Tiina Soon, EKI keelekorraldusosakonna vanemteadur Peeter Päll, Justiitsministeeriumi avalike suhete talituse juhataja Ivi Papstel

  7. Sisällönhallintajärjestelmä verkkosivuston alustana

    OpenAIRE

    Lehtisaari, Harri

    2013-01-01

    Insinöörityössä selvitettiin avoimen lähdekoodin WordPress-sisällönhallintajärjestelmän soveltuvuutta verkkosivujen alustaksi. Työssä vertailtiin eri sisällönhallintajärjestelmiä asiakkaan toimittamien vaatimusten mukaisesti, minkä pohjalta valittiin soveltuva sisällönhallintajärjestelmä. Soveltuvimmaksi sisällönhallintajärjestelmäksi todettiin WordPress. WordPress asennettiin testipalvelimelle, jolla sivusto rakennettiin ennen sen siirtämistä asiakkaan käyttöön. Insinöörityössä perehdytti...

  8. Adsorption Kinetics of Cd(ll and Pb(ll Ions from Aqueous Solutions by Bamboo-Based Activated Charcoal and Bamboo Dust

    Directory of Open Access Journals (Sweden)

    Stevens Azubuike Odoemelam

    2015-01-01

    Full Text Available The use of bamboo dust (BD and bamboo-based activated charcoal for adsorption of Pb(ll and Cd(ll ions from aqueous solutions were assessed in this work. The effect of contact time on the uptake of these metal ions was studied in batch process. The adsorption data were correlated with pseudo first-order, pseudo second-order and diffusivity kinetic models. Results show that pseudo second-order kinetic model gave the best description for the adsorption process. Kinetic studies further showed that the adsorption transport mechanism was particle-diffusion controlled for the adsorption process. Results obtained generally showed that lead(ll ions were better adsorbed onto both adsorbents as compared to cadmium(ll. Comparison of sorption capacity for the two adsorbents shows that bamboo-based activated charcoal exhibited better removal for the metal ions than the bamboo dust.

  9. Effects of conditioned medium from LL-37 treated adipose stem cells on human fibroblast migration.

    Science.gov (United States)

    Yang, Eun-Jung; Bang, Sa-Ik

    2017-07-01

    Adipose stem cell-conditioned medium may promote human dermal fibroblast (HDF) proliferation and migration by activating paracrine peptides during the re-epithelization phase of wound healing. Human antimicrobial peptide LL-37 is upregulated in the skin epithelium as part of the normal response to injury. The effects of conditioned medium (CM) from LL-37 treated adipose stem cells (ASCs) on cutaneous wound healing, including the mediation of fibroblast migration, remain to be elucidated, therefore the aim of the present study was to determine how ASCs would react to an LL-37-rich microenvironment and if CM from LL-37 treated ASCs may influence the migration of HDFs. The present study conducted migration assays with HDFs treated with CM from LL-37 treated ASCs. Expression of CXC chemokine receptor 4 (CXCR4), which controls the recruitment of HDFs, was analyzed at the mRNA and protein levels. To further characterize the stimulatory effects of LL-37 on ASCs, the expression of stromal cell-derived factor-1α (SDF-1α), a CXC chemokine, was investigated. CM from LL-37-treated ASCs induced migration of HDFs in a time- and dose-dependent manner, with a maximum difference in migration observed 24 h following stimulation with LL-37 at a concentration of 10 µg/ml. The HDF migration and the expression of CXCR4 in fibroblasts was markedly increased upon treatment with CM from LL-37-treated ASCs compared with CM from untreated ASCs. SDF-1α expression was markedly increased in CM from LL-37 treated ASCs. It was additionally observed that SDF-1α blockade significantly reduced HDF migration. These findings suggest the feasibility of CM from LL-37-treated ASCs as a potential therapeutic for human dermal fibroblast migration.

  10. OmpA Binding Mediates the Effect of Antimicrobial Peptide LL-37 on Acinetobacter baumannii.

    Directory of Open Access Journals (Sweden)

    Ming-Feng Lin

    Full Text Available Multidrug-resistant Acinetobacter baumannii has recently emerged as an important pathogen in nosocomial infection; thus, effective antimicrobial regimens are urgently needed. Human antimicrobial peptides (AMPs exhibit multiple functions and antimicrobial activities against bacteria and fungi and are proposed to be potential adjuvant therapeutic agents. This study examined the effect of the human cathelicidin-derived AMP LL-37 on A. baumannii and revealed the underlying mode of action. We found that LL-37 killed A. baumannii efficiently and reduced cell motility and adhesion. The bacteria-killing effect of LL-37 on A. baumannii was more efficient compared to other AMPs, including human ß-defensin 3 (hBD3 and histatin 5 (Hst5. Both flow cytometric analysis and immunofluorescence staining showed that LL-37 bound to A. baumannii cells. Moreover, far-western analysis demonstrated that LL-37 could bind to the A. baumannii OmpA (AbOmpA protein. An ELISA assay indicated that biotin-labelled LL-37 (BA-LL37 bound to the AbOmpA74-84 peptide in a dose-dependent manner. Using BA-LL37 as a probe, the ~38 kDa OmpA signal was detected in the wild type but the ompA deletion strain did not show the protein, thereby validating the interaction. Finally, we found that the ompA deletion mutant was more sensitive to LL-37 and decreased cell adhesion by 32% compared to the wild type. However, ompA deletion mutant showed a greatly reduced adhesion defect after LL-37 treatment compared to the wild strain. Taken together, this study provides evidence that LL-37 affects A. baumannii through OmpA binding.

  11. SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice.

    Science.gov (United States)

    Lee, In Hye; Jung, Yu-Jin; Cho, Yong Gu; Nou, Ill Sup; Huq, Md Amdadul; Nogoy, Franz Marielle; Kang, Kwon-Kyoo

    2017-01-01

    Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus. We now demonstrate in this study how signal peptide LL-37 (SP-LL-37) can be used in rice resistance against bacterial leaf blight and blast. We synthesized LL-37 peptide and subcloned in a recombinant pPZP vector with pGD1 as promoter. SP-LL-37 was introduced into rice plants by Agrobacterium mediated transformation. Stable expression of SP-LL-37 in transgenic rice plants was confirmed by RT-PCR and ELISA analyses. Subcellular localization of SP-LL-37-GFP fusion protein showed evidently in intercellular space. Our data on testing for resistance to bacterial leaf blight and blast revealed that the transgenic lines are highly resistant compared to its wildtype. Our results suggest that LL-37 can be further explored to improve wide-spectrum resistance to biotic stress in rice.

  12. Cationic Antimicrobial Peptide LL-37 Is Effective against both Extra- and Intracellular Staphylococcus aureus

    Science.gov (United States)

    Noore, Jabeen; Noore, Adly

    2013-01-01

    The increasing resistance of bacteria to conventional antibiotics and the challenges posed by intracellular bacteria, which may be responsible for chronic and recurrent infections, have driven the need for advanced antimicrobial drugs for effective elimination of both extra- and intracellular pathogens. The purpose of this study was to determine the killing efficacy of cationic antimicrobial peptide LL-37 compared to conventional antibiotics against extra- and intracellular Staphylococcus aureus. Bacterial killing assays and an infection model of osteoblasts and S. aureus were studied to determine the bacterial killing efficacy of LL-37 and conventional antibiotics against extra- and intracellular S. aureus. We found that LL-37 was effective in killing extracellular S. aureus at nanomolar concentrations, while lactoferricin B was effective at micromolar concentrations and doxycycline and cefazolin at millimolar concentrations. LL-37 was surprisingly more effective in killing the clinical strain than in killing an ATCC strain of S. aureus. Moreover, LL-37 was superior to conventional antibiotics in eliminating intracellular S. aureus. The kinetic studies further revealed that LL-37 was fast in eliminating both extra- and intracellular S. aureus. Therefore, LL-37 was shown to be very potent and prompt in eliminating both extra- and intracellular S. aureus and was more effective in killing extra- and intracellular S. aureus than commonly used conventional antibiotics. LL-37 could potentially be used to treat chronic and recurrent infections due to its effectiveness in eliminating not only extracellular but also intracellular pathogens. PMID:23274662

  13. Ch(k) grammars: A characterization of LL(k) languages

    NARCIS (Netherlands)

    Becvar, J.; Nijholt, Antinus; Soisalon-Soininen, E.

    In this paper we introduce the class of so called Ch(k) grammars [pronounced "chain k grammars"]. This class of grammars is properly contained in the class of LR(k) grammars and it properly contains the LL(k) grammars. However, the family of Ch[k) languages coincides with the family of LL(k)

  14. The interaction of antimicrobial peptide LL-37 with artificial biomembranes: epifluorescence and impedance spectroscopy approach

    International Nuclear Information System (INIS)

    Neville, Frances; Cahuzac, Marjolaine; Nelson, Andrew; Gidalevitz, David

    2004-01-01

    Membrane interactions of the human antimicrobial peptide LL-37 have been studied by a variety of techniques including insertion assay, epifluorescence microscopy and impedance spectroscopy. This study makes use of lipid monolayers at the air-aqueous interface to mimic bacterial or eukaryotic membranes. It was found that LL-37 readily inserts into phosphatidylglycerol (PG) and lipid A monolayers, significantly disrupting their structure. In contrast, the structure of phosphatidylcholine (PC) monolayers remains virtually unaffected by LL-37, which is evident both from epifluorescence and electrochemical measurements. Impedance spectroscopy showed that the LL-37 rich PC monolayer remains an ideal capacitor while LL-37 enriched lipid A capacitance decreases significantly, suggesting an increase in layer thickness from peptide-lipid binding

  15. A formulation for the critical temperature T/sub c/ of Ll2-type superconductors

    International Nuclear Information System (INIS)

    Wang Rong-Yao; Zhang Xiao

    1985-01-01

    From the examination of Ll 2 type superconductors, the superconducting critical temperature T/sub b/ of Ll 2 -type superconductors is obtained by: T/sub c/ = 15.9T/sub B/V(B)G/sub A//(√M/sub m/) V(Ll 2 )/sub m/ G/sub B/ where T/sub B/ is the superconducting critical temperature of pure B, V(B) the atomic volume in pure B, V(Ll 2 )/sub m/ the average atomic volume in the Ll 2 type compound, M/sub m/ the average atomic weight of the compound, and G/sub A/, G/sub B/ are the Gordy electronegative values. (author)

  16. LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.

    Science.gov (United States)

    van der Does, Anne M; Beekhuizen, Henry; Ravensbergen, Bep; Vos, Tim; Ottenhoff, Tom H M; van Dissel, Jaap T; Drijfhout, Jan W; Hiemstra, Pieter S; Nibbering, Peter H

    2010-08-01

    The human cathelicidin LL-37 has broad-spectrum antimicrobial activity. It also participates at the interface of innate and adaptive immunity by chemoattracting immune effector cells, modulating the production of a variety of inflammatory mediators by different cell types, and regulating the differentiation of monocytes into dendritic cells. In this study, we investigated the effects of LL-37 on the differentiation of human monocytes into anti-inflammatory macrophages (MPhi-2; driven by M-CSF) versus proinflammatory macrophages (MPhi-1; driven by GM-CSF) as well as on fully differentiated MPhi-1 and MPhi-2. Results revealed that monocytes cultured with M-CSF in the presence of LL-37 resulted in macrophages displaying a proinflammatory signature, namely, low expression of CD163 and little IL-10 and profound IL-12p40 production on LPS stimulation. The effects of LL-37 on M-CSF-driven macrophage differentiation were dose- and time-dependent with maximal effects observed at 10 microg/ml when the peptide was present from the start of the cultures. The peptide enhanced the GM-CSF-driven macrophage differentiation. Exposure of fully differentiated MPhi-2 to LL-37 for 6 d resulted in macrophages that produced less IL-10 and more IL-12p40 on LPS stimulation than control MPhi-2. In contrast, LL-37 had no effect on fully differentiated MPhi-1. Peptide mapping using a set of 16 overlapping 22-mer peptides covering the complete LL-37 sequence revealed that the C-terminal portion of LL-37 is responsible for directing macrophage differentiation. Our results furthermore indicate that the effects of LL-37 on macrophage differentiation required internalization of the peptide. Together, we conclude that LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.

  17. LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline.

    LENUS (Irish Health Repository)

    Bergsson, Gudmundur

    2009-07-01

    There is an abundance of antimicrobial peptides in cystic fibrosis (CF) lungs. Despite this, individuals with CF are susceptible to microbial colonization and infection. In this study, we investigated the antimicrobial response within the CF lung, focusing on the human cathelicidin LL-37. We demonstrate the presence of the LL-37 precursor, human cathelicidin precursor protein designated 18-kDa cationic antimicrobial protein, in the CF lung along with evidence that it is processed to active LL-37 by proteinase-3. We demonstrate that despite supranormal levels of LL-37, the lung fluid from CF patients exhibits no demonstrable antimicrobial activity. Furthermore Pseudomonas killing by physiological concentrations of exogenous LL-37 is inhibited by CF bronchoalveolar lavage (BAL) fluid due to proteolytic degradation of LL-37 by neutrophil elastase and cathepsin D. The endogenous LL-37 in CF BAL fluid is protected from this proteolysis by interactions with glycosaminoglycans, but while this protects LL-37 from proteolysis it results in inactivation of LL-37 antimicrobial activity. By digesting glycosaminoglycans in CF BAL fluid, endogenous LL-37 is liberated and the antimicrobial properties of CF BAL fluid restored. High sodium concentrations also liberate LL-37 in CF BAL fluid in vitro. This is also seen in vivo in CF sputum where LL-37 is complexed to glycosaminoglycans but is liberated following nebulized hypertonic saline resulting in increased antimicrobial effect. These data suggest glycosaminoglycan-LL-37 complexes to be potential therapeutic targets. Factors that disrupt glycosaminoglycan-LL-37 aggregates promote the antimicrobial effects of LL-37 with the caveat that concomitant administration of antiproteases may be needed to protect the now liberated LL-37 from proteolytic cleavage.

  18. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol

    KAUST Repository

    Liu, Xiang; Bastian, Sabine; Snow, Christopher D.; Brustad, Eric M.; Saleski, Tatyana E.; Xu, Jian-He; Meinhold, Peter; Arnold, Frances H.

    2013-01-01

    We have determined the X-ray crystal structures of the NADH-dependent alcohol dehydrogenase LlAdhA from Lactococcus lactis and its laboratory-evolved variant LlAdhA(RE1) at 1.9Å and 2.5Å resolution, respectively. LlAdhA(RE1), which contains three

  19. M4SF-17LL010302072: The Roles of Diffusion and Corrosion in Radionuclide Retardation

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Balboni, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Atkins-Duffin, Cindy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-21

    This progress report (Level 4 Milestone Number M4SF-17LL010302072) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Crystalline Disposal R&D Activity Number M4SF-17LL01030207 and Crystalline International Collaborations Activity Number M4SF-17LL01030208. The focus of this research is the interaction of radionuclides with Engineered Barrier System (EBS) and host rock materials at various physicochemical conditions relevant to subsurface repository environments. They include both chemical and physical processes such as solubility, sorption, and diffusion.

  20. The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.

    Directory of Open Access Journals (Sweden)

    Silke M Currie

    Full Text Available Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions are urgently required. Cathelicidins are cationic host defence peptides expressed in the inflamed lung, with key roles in innate host defence against infection. We demonstrate that the human cathelicidin LL-37 has effective antiviral activity against RSV in vitro, retained by a truncated central peptide fragment. LL-37 prevented virus-induced cell death in epithelial cultures, significantly inhibited the production of new infectious particles and diminished the spread of infection, with antiviral effects directed both against the viral particles and the epithelial cells. LL-37 may represent an important targetable component of innate host defence against RSV infection. Prophylactic modulation of LL-37 expression and/or use of synthetic analogues post-infection may represent future novel strategies against RSV infection.

  1. Spin transfer coefficient DΛLL to Λ hyperon in semi-inclusive DIS at HERMES

    International Nuclear Information System (INIS)

    Belostotski, S; Veretennikov, D; Naryshkin, Yu

    2011-01-01

    Three components of the spin transfer coefficient from the longitudinally polarized electron/positron beam to the Λ or Λ-bar hyperon have been measured in the HERMES experiment. Kinematical dependencies of the spin-transfer have been studied. Averaged over Λ kinematics, longitudinal component of the spin transfer DΛ LL (along the virtual photon direction) to the Λ hyperon is found to be DΛ LL = 0.19 ± 0.04 stat ± 0.02 syst .

  2. Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe): A new radiomics descriptor.

    Science.gov (United States)

    Prasanna, Prateek; Tiwari, Pallavi; Madabhushi, Anant

    2016-11-22

    In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel. The hypothesis behind CoLlAGe is that benign and pathologic phenotypes even though they may appear similar on anatomic imaging, will differ in their local entropy patterns, in turn reflecting subtle local differences in tissue microarchitecture. We demonstrate CoLlAGe's utility in three clinically challenging classification problems: distinguishing (1) radiation necrosis, a benign yet confounding effect of radiation treatment, from recurrent tumors on T1-w MRI in 42 brain tumor patients, (2) different molecular sub-types of breast cancer on DCE-MRI in 65 studies and (3) non-small cell lung cancer (adenocarcinomas) from benign fungal infection (granulomas) on 120 non-contrast CT studies. For each of these classification problems, CoLlAGE in conjunction with a random forest classifier outperformed state of the art radiomic descriptors (Haralick, Gabor, Histogram of Gradient Orientations).

  3. Differential diagnosis of pulmonary emphysema using the CT index: LL%w

    Energy Technology Data Exchange (ETDEWEB)

    Kitahara, Yoshinari; Takamoto, Masahiro; Maruyama, Masao; Tanaka, Yasushi; Ishibashi, Tuneo; Shinoda, Atsushi [Ohmuta National Hospital, Fukuoka (Japan)

    1989-06-01

    We measured the computed tomography (CT) index, LL%w, in 81 patients of chronic obstructive pulmonary disease (COPD) and asthma. In this study we defined LL%w as the mean value of the proportion of the low density area under -950 Hounsfield units in the six lung fields: upper, middle and lower lung fields bilaterally, at deep expiration. To examine the usefulness of LL%w in differentiating pulmomary emphysema (PE) from bronchial asthma (BA) and chronic bronchitis (CB), we excluded the overlapped cases of each disease. Mean value (+- standard deviation) of LL%w in PE was 24.6+-20.2% (n=40), whereas it was 0.5+-0.8% (n=27) in BA and 0.2+-0.3% (n=14) in CB respectively. There were clear statistically differences in the values of LL%w between clinically diagnosed emphysema and others. We considered that the value of LL%w within 1% would be observed nonspecifically, because the frequent existence of low density areas originated in bronchial tangents and/or motion artifacts mainly in the left lower lung field. Thus we judged that cases with over 1% of LL%w had abnormal CT findings. The relationship between clinically diagnosed emphysema and CT abnormality (LL%w > 1%) was significant in the analysis of the four-fold table. The CT sensitivity for diagnosing PE was 100%, the CT specificity was 87.8%, and CT accuracy was 93.8%. When cases of LL%w > 1% were shown in BA or CB, it would be better to consider the existence of complicated emphysema or the presence of air trapping or air spaces of any origin. We compared three groups (A', E', C') selected from groups BA, PE and CB, respectively. The groups consisted of patients showing almost the same mean values of FEV{sub 1.0}/VC(%). The value of the LL%w of E', selected from PE, also showed a significantly higher value than those from BA or CB. (J.P.N).

  4. Differential diagnosis of pulmonary emphysema using the CT index: LL%w

    International Nuclear Information System (INIS)

    Kitahara, Yoshinari; Takamoto, Masahiro; Maruyama, Masao; Tanaka, Yasushi; Ishibashi, Tuneo; Shinoda, Atsushi

    1989-01-01

    We measured the computed tomography (CT) index, LL%w, in 81 patients of chronic obstructive pulmonary disease (COPD) and asthma. In this study we defined LL%w as the mean value of the proportion of the low density area under -950 Hounsfield units in the six lung fields: upper, middle and lower lung fields bilaterally, at deep expiration. To examine the usefulness of LL%w in differentiating pulmomary emphysema (PE) from bronchial asthma (BA) and chronic bronchitis (CB), we excluded the overlapped cases of each disease. Mean value (± standard deviation) of LL%w in PE was 24.6±20.2% (n=40), whereas it was 0.5±0.8% (n=27) in BA and 0.2±0.3% (n=14) in CB respectively. There were clear statistically differences in the values of LL%w between clinically diagnosed emphysema and others. We considered that the value of LL%w within 1% would be observed nonspecifically, because the frequent existence of low density areas originated in bronchial tangents and/or motion artifacts mainly in the left lower lung field. Thus we judged that cases with over 1% of LL%w had abnormal CT findings. The relationship between clinically diagnosed emphysema and CT abnormality (LL%w > 1%) was significant in the analysis of the four-fold table. The CT sensitivity for diagnosing PE was 100%, the CT specificity was 87.8%, and CT accuracy was 93.8%. When cases of LL%w > 1% were shown in BA or CB, it would be better to consider the existence of complicated emphysema or the presence of air trapping or air spaces of any origin. We compared three groups (A', E', C') selected from groups BA, PE and CB, respectively. The groups consisted of patients showing almost the same mean values of FEV 1.0 /VC(%). The value of the LL%w of E', selected from PE, also showed a significantly higher value than those from BA or CB. (J.P.N)

  5. The impact of cathelicidin, the human antimicrobial peptide LL-37 in urinary tract infections.

    Science.gov (United States)

    Babikir, Ibrahim H; Abugroun, Elsir A; Bilal, Naser Eldin; Alghasham, Abdullah Ali; Abdalla, Elmuataz Elmansi; Adam, Ishag

    2018-01-08

    The defense mechanisms of the urinary tract are attributed mainly to the innate immune system and the urinary tract urothelium which represent the first line of defense against invading pathogens and maintaining sterility of the urinary tract. There are only a few publications regarding cathelicidin (LL-37) and a urinary tract infection (UTI). This study was done to investigate the plasma and urine levels of human LL-37 in patients with UTI. A case-control study was conducted at Omdurman Hospital, Sudan during the period from August 2014 to May 2017. The cases were patients with confirmed UTI and the controls were healthy volunteers without UTI. Sociodemographic and clinical data were obtained from each participant using questionnaires. Urine cultures and antimicrobial susceptibility were tested. Plasma and urine levels of LL-37 were determined using an enzyme-linked immunosorbent assay (ELISA) kit. SPSS (version 16.0) was used for analyses. Cases and controls (87 in each arm) were matched according to their basic characteristics. Compared with controls, the median (inter-quartile) LL-37 level in plasma [2.100 (1.700-2.700) vs. 1.800 (1.000-2.200) ng/ml, P = 0.002] and in urine [0.900 (0.300-1.600) vs. 0.000 (0.000-1.000) ng/mg creatinine, P < 0.001] was significantly higher in cases. There was no significant difference in the median plasma [2.1 (1.7-2.9) vs. 2.000 (1.700-2.400) ng/ml, P = 0.561] and urine [0.850 (0.275-2.025) vs. 0.900 (0.250-1.350) ng/mg creatinine, P = 0.124]. The uropathogenic Escherichia coli (UPEC) was the predominant isolate, n = 38 (43.7%). LL-37 levels between the E. coli isolates and the other isolated organisms. There was no significant correlation between plasma and urine LL-37 levels (r = 0.221), even when the data of the cases were analyzed separately. LL-37 is notably increased among patients with UTI compared with normal control subjects. Severity of UTI increases the levels of LL-37. The increased level was

  6. Effect of lectin (ScLL on fibroblasts stimulated with LPS - an in vitro study

    Directory of Open Access Journals (Sweden)

    Manuella Verdinelli de Paula REIS

    Full Text Available Abstract: The lectin (ScLL extracted from the Synadenium carinatum plant has been evaluated as an immunomodulator in diseases such as asthma, neosporosis and leishmaniasis. However, it has not yet been evaluated in the oral cavity. This study evaluated the effect of ScLL on viability, proliferation and release of IL-10 in human gingival fibroblasts (HGF stimulated with lipopolysaccharide (LPS. HGF were stimulated with LPS 1 µg/ml and treated with ScLL in concentrations of 10, 5 and 2 µg/ml for 1 and 5 h, and evaluated by flow cytometry for viability, apoptosis (initial/advanced and necrosis. The supernatant was collected to detect release of IL-10 by ELISA. The proliferation was assessed with the BrdU assay. Positive control consisted of cells maintained in Dulbecco's Modified Eagles Medium (DMEM, and the negative control, of those kept in tap water. Data were analyzed by ANOVA and Dunnett's test (α = 0.05. No significant difference was found for ScLL concentrations regarding viability or initial and advanced apoptosis (p=0.455. All the groups, including the positive control, had a significantly lower necrosis parameter than negative control at 5 h (p < 0.001. No difference was found for proliferation among the experimental groups (p = 0.832. ScLL at 5 and 2 µg/ml resulted in a lower release of IL-10 than positive and negative controls at 5 h (p = 0.047. The results indicated that ScLL concentrations tested were not cytotoxic, and had no effect on proliferation and release of IL-10 parameters. A thorough understanding of ScLL, regarding its immunomodulatory potential, may open the door to new perspectives for dentistry.

  7. The Glanerbrug Breccia: Evidence for a Separate L/LL-Chondritic Parent Body?

    Science.gov (United States)

    Welten, K. C.; Lindner, L.; Poorter, R. P. E.; Kallemeyn, G. W.; Rubin, A. E.; Wasson, J. T.

    1992-07-01

    INTRODUCTION. On April 7, 1990, a brecciated ordinary chondrite fell through the roof of a house near Glanerbrug in the Netherlands and was shattered to pieces. The total weight of the recovered fragments was about 800 g, the largest piece weighing 135 g. This main fragment clearly shows the inhomogeneous structure of the Glanerbrug: a dark-grey breccia occasionally containing blackish inclusions, separated from a light-grey breccia by a sharp boundary. Chondrules seem to be more common in the light grey parts. On the basis of earlier electron microprobe analyses of olivines and pyroxenes the light-grey portion was classified at the high Fa-Fs end of the L-field and the dark-grey part at the high Fa-Fs end of the LL-field [1]. Since it is not likely that the L and LL chondritic fragments originated on a single parent body, two alternative explanations were suggested: (i) The light-dark structure of the Glanerbrug is a characteristic feature of regolithic breccias, which once resided on or close to the surface of its parent body [2]. This lends some support to the idea that the light portion is an exotic clast in a dark host rock or vice versa; (ii) the two lithologies represent materials of a body having compositions between L and LL tentatively designated as L/LL [3,4]. Therefore additional electron microprobe analyses (EPMA) of silicates and kamacites in combination with neutron-activation analyses (INAA) of a light and a dark fragment and a noble gas analysis of a mixed light-dark fragment were undertaken. RESULTS and DISCUSSION. The light lithology in two thin sections shows olivine compositions in the L range (24.5+-0.3% Fa) and kamacite compositions (13.0+-1.3 mg/g Co) close to the LL range, plotting in the L/LL rather than in the L field on a kamacite-Co vs. olivine-Fa diagram [3,4]. Whereas only one aberrant olivine grain (out of 50) was found in the light portion, the dark portion is less homogeneous: one thin section shows olivine and kamacite

  8. The Beer/Bethe/Uexküll paper (1899) and misinterpretations surrounding 'vitalistic behaviorism'.

    Science.gov (United States)

    Mildenberger, Florian

    2006-01-01

    In the history of behaviorism the paper of the three physiologists Theodor Beer, Albrecht Bethe and Jakob von Uexküll from 1899 plays an important role. Many researchers were influenced by this paper and identified it as fundamental for objective psychological research. But during the period of its adoption (1900-1925) psychologists did not notice that Beer, Bethe and Uexküll had distanced themselves from their own paper, because it had been ignored in physiological and biological discussions. Moreover, one of the three (Beer) had to resign from the scientific community because of private scandal and another one (Uexküll) changed all of his views and left the base of objective science for subjective vitalism. However, this did not change his adoption of behaviorism.

  9. Rb-Sr Isotopic Systematics of Alkali-Rich Fragments in the Yamato-74442 LL-Chondritic Breccia

    Science.gov (United States)

    Yokoyama, T.; Misawa, K.; Okano, O.; Shih, C.-Y.; Nyquist, L. E.; Simo, J. I.; Tappa, M. J.; Yoneda, S.

    2012-01-01

    Alkali-rich igneous fragments were identified in the brecciated LL-chondrites, Kr henberg (LL5)], Bhola (LL3-6) and Yamato (Y)-74442 (LL4), and show characteristic fractionation patterns of alkaline elements. The K-Rb-Cs-rich fragments in Kr henberg, Bhola, and Y-74442 are very similar in mineralogy and petrography (olivine + pyroxene + glass), suggesting that they could have come from related precursor materials. We have undertaken Rb-Sr isotopic studies on alkali-rich fragments in Y-74442 to precisely determine their crystallization ages and the isotopic signatures of their precursor material(s).

  10. Sisällönanalyysi Journal of Aesthetic Nursing -julkaisusta

    OpenAIRE

    Pajunen, Eveliina

    2016-01-01

    Esteettisellä hoitotyöllä tarkoitetaan sellaisia elektiivisiä ja minimaalisen invasiivisia toimenpiteitä, joiden tarkoituksena on parantaa potilaan tyytyväisyyttä hänen fyysiseen olemukseensa. Tässä opinnäytetyössä käsitellään sairaanhoitajien tekemiä non-operatiivisia esteettisiä hoitotoimenpiteitä. Opinnäytetyön tarkoituksena oli tehdä sisällönanalyysi Journal of Aesthetic Nursing -julkaisusta, joka on ainut esteettisille sairaanhoitajille kohdennettu vertaisarvioitu julkaisu. Julkaisu ...

  11. M4FT-15LL0806062-LLNL Thermodynamic and Sorption Data FY15 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wolery, T. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-31

    This progress report (Milestone Number M4FT-15LL0806062) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within Work Package Number FT-15LL080606. The focus of this research is the thermodynamic modeling of Engineered Barrier System (EBS) materials and properties and development of thermodynamic databases and models to evaluate the stability of EBS materials and their interactions with fluids at various physicochemical conditions relevant to subsurface repository environments. The development and implementation of equilibrium thermodynamic models are intended to describe chemical and physical processes such as solubility, sorption, and diffusion.

  12. M4FT-16LL080302052-Update to Thermodynamic Database Development and Sorption Database Integration

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Inst.. Physical and Life Sciences; Wolery, T. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Akima Infrastructure Services, LLC; Atkins-Duffin, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Global Security

    2016-08-16

    This progress report (Level 4 Milestone Number M4FT-16LL080302052) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Argillite Disposal R&D Work Package Number FT-16LL08030205. The focus of this research is the thermodynamic modeling of Engineered Barrier System (EBS) materials and properties and development of thermodynamic databases and models to evaluate the stability of EBS materials and their interactions with fluids at various physico-chemical conditions relevant to subsurface repository environments. The development and implementation of equilibrium thermodynamic models are intended to describe chemical and physical processes such as solubility, sorption, and diffusion.

  13. On radiogenic nature of xenon-X in carbonaceous and LL chondrites

    International Nuclear Information System (INIS)

    Gerling, Eh.K.

    1982-01-01

    The nature of Xe-X from the mineral fraction produced during the differential dissolution of carbonaceous and LL chondrites was investigated using literature data on the age of some meteorites and their fractions and quantities of fission 136 Xe contained in them. A graph of lg fission 136 Xe against the age of meteorites was plotted; the decay constant of a hypothetical superheavy nucleus was calculated using the graph and equaled 1x10 - 7 year - 1 . The calculations served as a forcible argument for the radiogenic nature of xenon with 136 and 134 mass in carbonaceous and LL chondrites

  14. Does smoking affect gingival crevicular fluid LL-37 levels following non-surgical periodontal treatment in chronic periodontitis?

    Science.gov (United States)

    Türkoğlu, Oya; Eren, Gülnihal; Emingil, Gülnur; Azarsız, Elif; Kutukculer, Necil; Atilla, Gül

    2016-01-01

    LL-37 contributes to maintaining the balance between health and disease. Smoking is a risk factor for periodontitis that impairs neutrophil functions. The aim of the present study was to comparatively evaluate gingival crevicular fluid (GCF) LL-37 levels in smoker and non-smoker chronic periodontitis (CP) patients and controls, as well as the effect of non-surgical periodontal treatment on GCF LL-37 levels. Thirty-one CP patients (16 smokers, 15 non-smokers) and thirty-one controls (16 smokers, 15 non-smokers) were included in the study. CP patients received non-surgical treatment. GCF LL-37 levels and periodontal parameters were assessed at baseline, 1 and 3 months after completion of non-surgical periodontal treatment. GCF LL-37 levels were analyzed by ELISA. No significant difference was observed in GCF LL-37 levels between smoker and non-smoker controls (p>0.05). Smoker CP group had significantly lower GCF LL-37 level than non-smoker CP group at baseline (pnon-smoker CP group at first week, 1 and 3 months after completion of non-surgical periodontal treatment (psmoker CP group (p>0.05). Periodontal parameters were correlated with GCF LL-37 levels in non-smoker CP group (psmoker CP group (p>0.05). GCF LL-37 levels do not seem to be affected from smoking in periodontal health. However, smoking might have a suppressive effect on GCF LL-37 levels in CP. Non-surgical treatment is effective in decreasing GCF LL-37 levels in non-smoker CP patients but not in smokers with CP. Copyright © 2015. Published by Elsevier Ltd.

  15. L-L multilevel boost converter topology for renewable energy applications

    DEFF Research Database (Denmark)

    Bhaskar, Mahajan Sagar; Padmanaban, Sanjeevikumar; Fedák, Viliam

    2017-01-01

    ; such as a photovoltaic (PV) system with a Multilevel Inverter (MLI), electrical drives, automotive, hybrid electric cars etc. The proposed topology is derived by attaching the Cockcroft Walton (CW) multiplier to an upper L-converter of the LL topology of XY family. The mode of operation of L-LMBC with mathematical...

  16. Physical properties, structure and fracturing of the Chelyabinsk LL5 meteorite body

    Czech Academy of Sciences Publication Activity Database

    Grokhovsky, V. I.; Kohout, Tomáš; Gritsevich, M.; Koneva, E. V.

    2014-01-01

    Roč. 49, Special issue 1 (2014), pdf 5364-pdf 5364 ISSN 1086-9379. [Annual Meeting of the Meteoritical Society /77./. 08.09.2014-13.09.2014, Casablanca] Institutional support: RVO:67985831 Keywords : Chelyabinsk * LL chondrite * physical properties * structure * mechanical properties * stress Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics http://www.hou.usra.edu/meetings/metsoc2014/pdf/5364.pdf

  17. The School Business Official: Ten Habits You'll Need To Succeed.

    Science.gov (United States)

    Giambrone, William, Jr.

    2001-01-01

    Describes 10 habits school business officials need to succeed: organization, time management, delegation, planning, collaboration, personal development, creativity, empathy, ethos, and leadership. Based on book "The School Business Official: Ten Habits You'll Need To Succeed," published by the Pennsylvania Association of School Business…

  18. Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging

    NARCIS (Netherlands)

    Ordonez Alvarez, Soledad; Amarullah, Ilham H; Wubbolts, Richard W; Veldhuizen, Edwin J A; Haagsman, Henk P

    2014-01-01

    Antifungal mechanisms of action of two cathelicidins, chicken CATH-2 and human LL-37, were studied and compared with the mode of action of the salivary peptide histatin 5 (Hst5). Candida albicans was used as a model organism for fungal pathogens. Analysis by live-cell imaging showed that the

  19. Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells

    Directory of Open Access Journals (Sweden)

    Justyna Agier

    2018-01-01

    Full Text Available Undoubtedly, mast cells take part in host defense against microorganisms as they are numerous at the portal of infection, they release many proinflammatory and antimicrobial mediators, and they express pattern recognition receptors, such as TLRs. These receptors play a key role in recognition and binding molecules associated with microorganisms and molecules associated with damage. Cathelicidins exhibit direct antimicrobial activities against a broad spectrum of microbes by perturbing their cell membranes. Accumulating evidence suggests a role for these molecules in supporting cell activation. We examined the impact of human cathelicidin LL-37 on tissue mast cell TLR expression and distribution. Depending on context, we show that LL-37 stimulation resulted in minor to major effects on TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9 expression. Confocal microscopy analysis showed that, upon stimulation, TLRs may translocate from the cell interior to the surface and conversely. FPR2 and EGFR inhibitors reduced the increase in expression of selected receptors. We also established that LL-37 acts as a powerful inducer of CCL3 and ROS generation. These results showed that in response to LL-37, mast cells enhance the capability to detect invading pathogens by modulation of TLR expression in what may be involved FPR2 or EGFR molecules.

  20. Effektregnskab for projektet Digitales ll – Det svære valg

    DEFF Research Database (Denmark)

    Mark, Stine

    Effektregnskabet for projektet Digitales ll – Det svære valg er udarbejdet af forskningscenteret INCEVIDA, Aalborg Universitet 2012. Rapporten er gennemført i et samarbejde mellem INCEVIDA, KulturarvNord og Bangsbo Museum. Effektregnskabet tager udgangspunkt i en model for oplevelsesøkonomisk...

  1. checkCIF/PLATON report Datablock: ll5182-c2m

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: ll5182-c2m. Bond precision:.

  2. Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells

    OpenAIRE

    Liu, Q.; Liu, J.; Roschmann, K.I.L.; Egmond, D. van; Golebski, K.; Fokkens, W.J.; Wang, D.; Drunen, C.M. van

    2013-01-01

    HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely unknown. Therefore, we investigated the effects of two non-selective HDACi, trichostatin A (TSA) and sodium butyrate (SB), on the expression of the cathelicidin LL-37 in human airway epithelial cells. LL3...

  3. K-Ca Dating of Alkali-Rich Fragments in the Y-74442 and Bhola LL-Chondritic Breccias

    Science.gov (United States)

    Yokoyama, T; Misawa, K.; Okano, O; Shih, C. -Y.; Nyquist, L. E.; Simon, J. I.; Tappa, M. J.; Yoneda, S.

    2013-01-01

    Alkali-rich igneous fragments in the brecciated LL-chondrites, Krahenberg (LL5) [1], Bhola (LL3-6) [2], Siena (LL5) [3] and Yamato (Y)-74442 (LL4) [4-6], show characteristic fractionation patterns of alkali and alkaline elements [7]. The alkali-rich fragments in Krahenberg, Bhola and Y-74442 are very similar in mineralogy and petrography, suggesting that they could have come from related precursor materials [6]. Recently we reported Rb-Sr isotopic systematics of alkali-rich igneous rock fragments in Y-74442: nine fragments from Y-74442 yield the Rb-Sr age of 4429 plus or minus 54 Ma (2 sigma) for lambda(Rb-87) = 0.01402 Ga(exp -1) [8] with the initial ratio of Sr-87/Sr-86 = 0.7144 plus or minus 0.0094 (2 sigma) [9]. The Rb-Sr age of the alkali-rich fragments of Y-74442 is younger than the primary Rb-Sr age of 4541 plus or minus 14 Ma for LL-chondrite whole-rock samples [10], implying that they formed after accumulation of LL-chondrite parental bodies, although enrichment may have happened earlier. Marshall and DePaolo [11,12] demonstrated that the K-40 - Ca-40 decay system could be an important chronometer as well as a useful radiogenic tracer for studies of terrestrial rocks. Shih et al. [13,14] and more recently Simon et al. [15] determined K-Ca ages of lunar granitic rocks, and showed the application of the K-Ca chronometer for K-rich planetary materials. Since alkali-rich fragments in the LL-chondritic breccias are highly enriched in K, we can expect enhancements of radiogenic Ca-40. Here, we report preliminary results of K-Ca isotopic systematics of alkali-rich fragments in the LL-chondritic breccias, Y-74442 and Bhola.

  4. Initiated into Subordination. On Joyce Carol Oates’s I’ll Take You There

    Directory of Open Access Journals (Sweden)

    Zawadzka Anna

    2016-12-01

    Full Text Available The article proposes a sociological reading of the novel I’ll Take You There by Joyce Carol Oates. Though the book can be classified as an initiation novel, it also constitutes an accusation of the very procedure of initiation as forcing individuals to agree and adapt to unfair social mechanisms. The context of the protagonist’s struggles is provided by the social structure of the early-1960s United States, with its inherent misogyny, anti-Semitism, racism and classism. All these factors shape her destiny in accordance with the logic of social reproduction. A destiny of overwhelming power of allocation, which the heroine is trying to resist. As an academic novel, I’ll Take You There is also an insightful deconstruction of the universalism preached within the Western academic world, and especially philosophy.

  5. Rare top decay t{yields}c anti ll as a probe of new physics

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Cruz, J.L.; Diaz-Furlong, A. [BUAP, Cuerpo Academico de Particulas, Campos y Relatividad Facultad de Ciencias Fisico-Matematicas, Apdo. Postal 1364, Puebla, Pue. (Mexico); Gaitan-Lozano, R.; Montes de Oca Y, J.H. [UNAM, Departamento de Fisica, FES-Cuautitlan, Estado de Mexico (Mexico)

    2012-08-15

    The rare top decay t{yields}c anti ll, which involves flavor violation, is studied as a possible probe of new physics. This decay is analyzed with one of the simplest Standard Model extensions with additional gauge symmetry formalism. The considered extension is the Left-Right Symmetric Model, including a new neutral gauge boson Z' that allows one to obtain the decay at tree level through Flavor-Changing Neutral Currents (FCNC) couplings. The neutral gauge boson couplings are considered diagonal but family non-universal in order to induce these FCNC. We find BR(t{yields}c anti ll){proportional_to}10{sup -13} for the range 1 TeV{<=}M{sub Z'}{<=}3 TeV. (orig.)

  6. Purification and partial characterization of bacteriocin produced by Lactococcus lactis ssp. lactis LL171.

    Science.gov (United States)

    Kumari, Archana; Akkoç, Nefise; Akçelik, Mustafa

    2012-04-01

    Lactic acid bacteria (LAB) are possessing ability to synthesize antimicrobial compounds (like bacteriocin) during their growth. In this regard, novel bacteriocin compound secreting capability of LAB isolated from Tulum Cheese in Turkey was demonstrated. The synthesized bacteriocin was purified by ammonium sulphate precipitation, dialysis and gel filtration. The molecular weight (≈3.4 kDa) of obtained bacteriocin was confirmed by SDS-PAGE, which revealed single peptide band. Molecular identification of LAB strain isolated from Tulum Cheese was conducted using 16S rDNA gene sequencing as Lactococcus lactis ssp. lactis LL171. The amino acid sequences (KKIDTRTGKTMEKTEKKIELSLKNMKTAT) of the bacteriocin from Lactococcus lactis ssp. lactis LL171 was found unique and novel than reported bacteriocins. Further, the bacteriocin was possessed the thermostable property and active at wide range of pH values from 1 to 11. Thus, bacteriocin reported in this study has the potential applications property as food preservative agent.

  7. Composite-model view of the ll-barγγ events at LEP

    International Nuclear Information System (INIS)

    Akama, Keiichi; Terazawa, Hidezumi.

    1993-09-01

    We examine phenomenological consistency of composite-model pictures for the ll-barγγ events at LEP: the picture with an extra boson and that with an excited lepton. It turns out that the former is inconsistent with the Bhabha scattering data while the latter is consistent with the existing experimental data as far as the excited lepton is lighter than 200 GeV. (author)

  8. Bitumen and cement solidifications of LL and ML liquid radwaste. The SGN experience

    International Nuclear Information System (INIS)

    Tchemitcheff, E.; Roux, P.

    1993-01-01

    The presentation is focused on the thin-film evaporator technology and the experience gained in the field of the NPPs and research centers on radwaste conditioning. As early as 1970, SGN was licensed by the CEA for the bituminization of LL and ML radwaste. With the support of EDF and COGEMA, SGN has been performing in depth research on cement solidification of borated concentrates and ion exchange resins generated by reactors or reprocessing plant since 1983

  9. Lymphoma imaging with a new technetium-99m labelled antibody, LL2

    International Nuclear Information System (INIS)

    Murthy, S.; Sharkey, R.M.; Goldenberg, D.M.; Lee, R.E.; Pinsky, C.M.; Hansen, H.J.; Burger, K.; Swayne, L.C.

    1992-01-01

    The lesion detection capability of a new technetium-99m labelled B-cell lymphoma monoclonal antibody (MoAb) imaging agent, LL2, was evaluated in 8 patients with non-Hodgkin's lymphoma and 1 patient with chronic lymphocytic leukaemia. The MoAb kit consists of a 1-vial, 1-mg Fab' form of LL2 ready for instant labelling with technetium. The patients were injected with ∝925 MBq (25 mCi) of 99m Tc-LL2 Fab' (1 mg), and planar and single photon emission tomography (SPET) studies were performed at 3-4 h post injection and at 24 h. There was no evidence of thyroid or stomach activity up to 24 h. Uniform splenic uptake was seen in all patients. Two non-lymphoma patients were also administered with the same agent and demonstrated a similar splenic distribution; therefore, splenic targeting was not scored as tumour-specific. A total of 29 from 48 tumour sites were detected by scintigraphy, including tumours of various grades and histological types. Excluding 1 patient who had a large tumour burden of over 500 g, 29 of 33 lesions were detected. One patient was free of disease at the time of the study and had a negative scan. Another patient showed excellent targeting of gallium-negative sites in the liver and bone. The bone involvement was not known prior to the antibody study and was subsequently confirmed by a bone scan. Additional sites of MoAb localization could not be followed in this group, since most patients went on to radioimmunotherapy immediately following the 99m Tc-LL2 study. However, these initial results suggest that this new 99m Tc-labelled antibody imaging kit should be further investigated for its potential role in the staging and follow-up of lymphoma patients. (orig.)

  10. The taxonomic status of Bryum arachnoideum C. Müll. and B. lanatum (P. Beauv.) Brid.

    OpenAIRE

    Frahm, Jan-Peter

    2002-01-01

    A study of an isotype of Bryum arachnoideum C. Müll., a poorly understood species described from tropical Africa, revealed that this species is distinct from B. argenteum Hedw. var. lanatum (P. Beauv.) Hampe. The differences between both species are listed. All specimens from tropical Africa named as B. arachnoideum by the author must be attributed to B. argenteum var. lanatum. The differences between B. argenteum var. argenteum and var. lanatum, both morphologically and ecologically, are so ...

  11. An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.

    Science.gov (United States)

    Hudson, André O; Singh, Bijay K; Leustek, Thomas; Gilvarg, Charles

    2006-01-01

    Although lysine (Lys) biosynthesis in plants is known to occur by way of a pathway that utilizes diaminopimelic acid (DAP) as a central intermediate, the available evidence suggests that none of the known DAP-pathway variants found in nature occur in plants. A new Lys biosynthesis pathway has been identified in Arabidopsis (Arabidopsis thaliana) that utilizes a novel transaminase that specifically catalyzes the interconversion of tetrahydrodipicolinate and LL-diaminopimelate, a reaction requiring three enzymes in the DAP-pathway variant found in Escherichia coli. The LL-DAP aminotransferase encoded by locus At4g33680 was able to complement the dapD and dapE mutants of E. coli. This result, in conjunction with the kinetic properties and substrate specificity of the enzyme, indicated that LL-DAP aminotransferase functions in the Lys biosynthetic direction under in vivo conditions. Orthologs of At4g33680 were identified in all the cyanobacterial species whose genomes have been sequenced. The Synechocystis sp. ortholog encoded by locus sll0480 showed the same functional properties as At4g33680. These results demonstrate that the Lys biosynthesis pathway in plants and cyanobacteria is distinct from the pathways that have so far been defined in microorganisms.

  12. Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37.

    Science.gov (United States)

    Schögler, Aline; Muster, Ricardo J; Kieninger, Elisabeth; Casaulta, Carmen; Tapparel, Caroline; Jung, Andreas; Moeller, Alexander; Geiser, Thomas; Regamey, Nicolas; Alves, Marco P

    2016-02-01

    Vitamin D has immunomodulatory properties in the defence against pathogens. Its insufficiency is a widespread feature of cystic fibrosis (CF) patients, which are repeatedly suffering from rhinovirus (RV)-induced pulmonary exacerbations.To investigate whether vitamin D has antiviral activity, primary bronchial epithelial cells from CF children were pre-treated with vitamin D and infected with RV16. Antiviral and anti-inflammatory activity of vitamin D was assessed. RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10(-7 )M, pvitamin D in CF cells. Vitamin D did not exert anti-inflammatory properties in RV-infected CF cells. Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (pvitamin D through the induction of LL-37. Clinical studies are needed to determine the importance of an adequate control of vitamin D for prevention of virus-induced pulmonary CF exacerbations. Copyright ©ERS 2016.

  13. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Shu Meguro

    2014-01-01

    Full Text Available Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%. Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=−0.450, P<0.01, triglyceride (r=0.445, P<0.01, and high sensitive C-reactive protein (r=0.316, P<0.01 but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=−0.411, P<0.01 and high sensitive C-reactive protein (β=0.193, P<0.05. Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

  14. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol

    KAUST Repository

    Liu, Xiang

    2013-03-01

    We have determined the X-ray crystal structures of the NADH-dependent alcohol dehydrogenase LlAdhA from Lactococcus lactis and its laboratory-evolved variant LlAdhA(RE1) at 1.9Å and 2.5Å resolution, respectively. LlAdhA(RE1), which contains three amino acid mutations (Y50F, I212T, and L264V), was engineered to increase the microbial production of isobutanol (2-methylpropan-1-ol) from isobutyraldehyde (2-methylpropanal). Structural comparison of LlAdhA and LlAdhA(RE1) indicates that the enhanced activity on isobutyraldehyde stems from increases in the protein\\'s active site size, hydrophobicity, and substrate access. Further structure-guided mutagenesis generated a quadruple mutant (Y50F/N110S/I212T/L264V), whose KM for isobutyraldehyde is ∼17-fold lower and catalytic efficiency (kcat/KM) is ∼160-fold higher than wild-type LlAdhA. Combining detailed structural information and directed evolution, we have achieved significant improvements in non-native alcohol dehydrogenase activity that will facilitate the production of next-generation fuels such as isobutanol from renewable resources.

  15. Paralogs hnRNP L and hnRNP LL exhibit overlapping but distinct RNA binding constraints.

    Directory of Open Access Journals (Sweden)

    Sarah A Smith

    Full Text Available HnRNP (heterogeneous nuclear ribonucleoprotein proteins are a large family of RNA-binding proteins that regulate numerous aspects of RNA processing. Interestingly, several paralogous pairs of hnRNPs exist that exhibit similar RNA-binding specificity to one another, yet have non-redundant functional targets in vivo. In this study we systematically investigate the possibility that the paralogs hnRNP L and hnRNP LL have distinct RNA binding determinants that may underlie their lack of functional redundancy. Using a combination of RNAcompete and native gel analysis we find that while both hnRNP L and hnRNP LL preferentially bind sequences that contain repeated CA dinucleotides, these proteins differ in their requirement for the spacing of the CAs. Specifically, hnRNP LL has a more stringent requirement for a two nucleotide space between CA repeats than does hnRNP L, resulting in hnRNP L binding more promiscuously than does hnRNP LL. Importantly, this differential requirement for the spacing of CA dinucleotides explains the previously observed differences in the sensitivity of hnRNP L and LL to mutations within the CD45 gene. We suggest that overlapping but divergent RNA-binding preferences, as we show here for hnRNP L and hnRNP LL, may be commonplace among other hnRNP paralogs.

  16. Operational safety and radioprotection considerations when designing the ILW-LL disposal zone

    International Nuclear Information System (INIS)

    Voinis, S.; Roulet, A.; Claudel, D.; Lesavre, A.

    2008-01-01

    As for any other nuclear industrial facility, in a radioactive waste repository the various waste disposal operational activities from construction to closure can present a risk to human (workers and public) and the environment. In accordance with the December 30, 1991 French Waste Act, Andra has conducted feasibility studies regarding the disposal of HLW and ILW-LL waste in a clay host formation. The 'Dossier 2005 - Clay' includes a description of the operational safety analysis that was conducted for ILW-LL waste disposal in underground horizontal drifts. The objective of this paper is to present that safety analysis and its impact on the design at the feasibility stage. The safety analysis covered the operations from the reception of the waste transport casks to the disposal of the waste disposal package in its final emplacement location inside the disposal cell. Since the surface facilities' operations are similar to those of other nuclear ones, this paper focuses on the specificity of the deep repository, i.e. the operational safety and radioprotection aspects applied to the deep disposal drift. Andra has selected an ILW-LL design based on large horizontal drifts (diameters of 10 to 12 m, and lengths of 250 m). The primary waste packages are put inside a specific concrete overpack before their disposal. These overpacks are remotely stacked inside the horizontal drifts. The operational safety analysis aims to ensure that risks are kept under control through provisions in the design of the repository and by operating the facility in compliance with operational requirements and the safety functions. The requirements and the safety functions, developed at this stage of the feasibility studies, will be explained. The operational safety analysis is structured around physical components and real activities (construction, operation, closure) through a dedicated risk analysis. Due to the large variety of different ILW-LL waste, in order to identify the potential

  17. Chapa aglomerada de cimento-madeira de Hevea brasiliensis Müll. Arg. Cement-bonded particleboard of Hevea brasiliensis Müll. Arg.

    Directory of Open Access Journals (Sweden)

    Esmeralda Yoshico Arakaki Okino

    2004-06-01

    Full Text Available Chapas de partículas de cimento-madeira foram confeccionadas com a madeira de quatro clones de Hevea brasiliensis Müll. Arg. (seringueira: IAN 717, IAN 873, GT 711 e AVROS 1301. Confeccionaram-se as chapas na proporção de 1:4:1 (madeira:cimento:água por peso e nas dimensões de 450 x 450 x 13 mm e densidade nominal de 1,4 g/cm³, com a adição de 4% de cloreto de cálcio di-hidratado (CaCl2.2H2O como acelerador. Foram testadas partículas fervidas e não-fervidas dos quatro clones, totalizando oito tratamentos, sendo em cada um destes, com quatro repetições, avaliadas as propriedades mecânicas e físicas das chapas, segundo a norma ASTM D 1037 - 96a. De forma geral, os melhores resultados de propriedades físicas e mecânicas foram obtidos nas chapas com partículas do clone AVROS 1301. No teste de hidratação do cimento, a madeira de seringueira in natura foi classificada como de "inibição extrema", porém com a adição de CaCl2 o foi como de "baixa inibição". Essa madeira se mostrou tecnicamente viável à produção de chapas de cimento-madeira, independentemente do clone.Cement-bonded particleboards of rubberwood were manufactured with four clones of Hevea brasiliensis Müll. Arg. (rubberwood: IAN 717, IAN 873, GT 711 and AVROS 1301. Boards of 450 x 450 x 13 mm were manufactured in a ratio of 1:4:1 (wood/cement/water, weight basis, with 1.4 g/cm³ density and 4% calcium chloride dihydrated - CaCl2.2H2O as accelerator. The particles of four clones were tested in treated and untreated conditions, totaling eight treatments. In each treatment with four replicates, the physical and mechanical properties were evaluated according to ASTM D 1037 - 96a standard. Overall, the best mechanical and physical results were obtained with the cement-bonded particleboard made with particles from clone AVROS 1301. Rubberwood has shown to be "highly inhibitory" in the hydration test, however when CaCl2 was added the inhibition index decreased and

  18. Young asteroid mixing revealed in ordinary chondrites: The case of NWA 5764, a polymict LL breccia with L clasts

    Science.gov (United States)

    Gattacceca, Jérome; Krzesińska, Agata M.; Marrocchi, Yves; Meier, Matthias M. M.; Bourot-Denise, Michèle; Lenssen, Rob

    2017-11-01

    Polymict chondritic breccias—rocks composed of fragments originating from different chondritic parent bodies—are of particular interest because they give insights into the mixing of asteroids in the main asteroid belt (occurrence, encounter velocity, transfer time). We describe Northwest Africa (NWA) 5764, a brecciated LL6 chondrite that contains a >16 cm3 L4 clast. The L clast was incorporated in the breccia through a nondestructive, low-velocity impact. Identical cosmic-ray exposure ages of the L clast and the LL host (36.6 ± 5.8 Myr), suggest a short transfer time of the L meteoroid to the LL parent body of 0.1 ± 8.1 Myr, if that meteoroid was no larger than a few meters. NWA 5764 (together with St. Mesmin, Dimmitt, and Glanerbrug) shows that effective mixing is possible between ordinary chondrite parent bodies. In NWA 5764 this mixing occurred after the peak of thermal metamorphism on the LL parent body, i.e., at least several tens of Myr after the formation of the solar system. The U,Th-He ages of the L clast and LL host, identical at about 2.9 Ga, might date the final assembly of the breccia, indicating relatively young mixing in the main asteroid belt as previously evidenced in St. Mesmin.

  19. LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction.

    Science.gov (United States)

    Kishi, Masashi; Kummer, Terrance T; Eglen, Stephen J; Sanes, Joshua R

    2005-04-25

    In both neurons and muscle fibers, specific mRNAs are concentrated beneath and locally translated at synaptic sites. At the skeletal neuromuscular junction, all synaptic RNAs identified to date encode synaptic components. Using microarrays, we compared RNAs in synapse-rich and -free regions of muscles, thereby identifying transcripts that are enriched near synapses and that encode soluble membrane and nuclear proteins. One gene product, LL5beta, binds to both phosphoinositides and a cytoskeletal protein, filamin, one form of which is concentrated at synaptic sites. LL5beta is itself associated with the cytoplasmic face of the postsynaptic membrane; its highest levels border regions of highest acetylcholine receptor (AChR) density, which suggests a role in "corraling" AChRs. Consistent with this idea, perturbing LL5beta expression in myotubes inhibits AChR aggregation. Thus, a strategy designed to identify novel synaptic components led to identification of a protein required for assembly of the postsynaptic apparatus.

  20. Lactobacillus delbrueckii bakteriyofajı LL-H'nin konakçı spektrumu

    OpenAIRE

    Gökçe, Özge

    2010-01-01

    Bu çalışmada, 7 Lactobacillus delbrueckii ssp. lactis, 6 Lactobacillus delbrueckii ssp. bulgaricus ve 5 Lactobacillus helveticus suşu kullanılarak Lactobacillus delbrueckii bakteriyofajı LL-H'nin konakçı spektrumu incelenmiştir. Her bir suş için çift tabakalı plak titresi (double-layer plaque assay) yöntemi kullanılarak en az 2 tekrar ile adsorbsiyon kinetiği incelenmiştir. Adsorbsiyon kinetiğini incelemek için 0, 3, 10, 30 ve 50. dakikalar dikkate alınarak adsorbsiyon eğrileri oluşturulmuştu...

  1. Chapa aglomerada de cimento-madeira de Hevea brasiliensis Müll. Arg.

    OpenAIRE

    Okino,Esmeralda Yoshico Arakaki; Souza,Mário Rabelo de; Santana,Marcos Antonio Eduardo; Sousa,Maria Eliete de; Teixeira,Divino Eterno

    2004-01-01

    Chapas de partículas de cimento-madeira foram confeccionadas com a madeira de quatro clones de Hevea brasiliensis Müll. Arg. (seringueira): IAN 717, IAN 873, GT 711 e AVROS 1301. Confeccionaram-se as chapas na proporção de 1:4:1 (madeira:cimento:água) por peso e nas dimensões de 450 x 450 x 13 mm e densidade nominal de 1,4 g/cm³, com a adição de 4% de cloreto de cálcio di-hidratado (CaCl2.2H2O) como acelerador. Foram testadas partículas fervidas e não-fervidas dos quatro clones, totaliza...

  2. 27-day cycles in human mortality: Traute and Bernhard Düll

    Science.gov (United States)

    Halberg, F.; Düll-Pfaff, N.; Gumarova, L.; Zenchenko, T. A.; Schwartzkopff, O.; Freytag, E. M.; Freytag, J.; Cornelissen, G.

    2013-04-01

    This tribute to her parents by one co-author (NDP) is the fruit of a more than a decade-long search by the senior author (FH) for the details of the lives of Bernhard and Gertraud (''Traute'') Düll. These pioneers studied how space/terrestrial weather may differentially influence human mortality from various causes, the 27-day mortality pattern being different whether death was from cardiac or respiratory disease, or from suicide. FH is the translator of personal information about her parents provided by NDP in German. Figuratively, he also attempts to ''translate'' the Dülls' contribution in the context of the literature that had appeared before their work and after their deaths. Although the Dülls published in a then leading journal, among others (and FH had re-analyzed some of their work in a medical journal), they were unknown to academies or libraries (where FH had inquired about them). The Dülls thoroughly assembled death certificates to offer the most powerful evidence for an effect of solar activity reflected in human mortality, as did others before them. They went several steps further than their predecessors, however. They were the first to show possibly differential effects of space and/or Earth weather with respect to suicide and other deaths associated with the nervous and sensory systems vs. death from cardiac or respiratory disease as well as overall death by differences in the phase of a common 27-day cycle characterizing these mortality patterns. Furthermore, Bernhard Düll developed tests of human visual and auditory reaction time to study effects of weather and solar activity, publishing a book (his professorial dissertation) on the topic. His unpublished finding of an increased incidence of airplane crashes in association with higher solar activity was validated after his death, among others, by Tatiana Zenchenko and A. M. Merzlyi.

  3. 27-day cycles in human mortality: Traute and Bernhard Düll

    Directory of Open Access Journals (Sweden)

    F. Halberg

    2013-04-01

    Full Text Available This tribute to her parents by one co-author (NDP is the fruit of a more than a decade-long search by the senior author (FH for the details of the lives of Bernhard and Gertraud (''Traute'' Düll. These pioneers studied how space/terrestrial weather may differentially influence human mortality from various causes, the 27-day mortality pattern being different whether death was from cardiac or respiratory disease, or from suicide. FH is the translator of personal information about her parents provided by NDP in German. Figuratively, he also attempts to ''translate'' the Dülls' contribution in the context of the literature that had appeared before their work and after their deaths. Although the Dülls published in a then leading journal, among others (and FH had re-analyzed some of their work in a medical journal, they were unknown to academies or libraries (where FH had inquired about them. The Dülls thoroughly assembled death certificates to offer the most powerful evidence for an effect of solar activity reflected in human mortality, as did others before them. They went several steps further than their predecessors, however. They were the first to show possibly differential effects of space and/or Earth weather with respect to suicide and other deaths associated with the nervous and sensory systems vs. death from cardiac or respiratory disease as well as overall death by differences in the phase of a common 27-day cycle characterizing these mortality patterns. Furthermore, Bernhard Düll developed tests of human visual and auditory reaction time to study effects of weather and solar activity, publishing a book (his professorial dissertation on the topic. His unpublished finding of an increased incidence of airplane crashes in association with higher solar activity was validated after his death, among others, by Tatiana Zenchenko and A. M. Merzlyi.

  4. Siim Nestor soovitab : uute eesti plaatide esitlusõhtud! Metro Luminal. Lu : K. Metsatöll / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2004-01-01

    Rockansambli Metro Luminal plaadi "Reboot" esitlusest Tartu Sadamateatris 9. dets. ja Rock Café's Tallinnas 10. dets.(kaasa teeb DJ Sing). Popansambli Lu:k albumist "Raadiomaja valvelauas" ja ansambli 10. aastapäeva tähistamisest 10. dets. Tallinnas Kunstiakadeemia saalis. Ansambli Metsatöll albumi "Hiiekoda" esitlusest 11.dets. Rock Café's Tallinnas

  5. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.

    Science.gov (United States)

    Tada, Hiroyuki; Shimizu, Takamitsu; Nagaoka, Isao; Takada, Haruhiko

    2016-01-01

    Maxacalcitol (22-oxacalcitriol: OCT) is a synthetic vitamin D3 analog with a limited calcemic effect. In this study, we investigated whether OCT increases the production of LL-37/CAP-18, a human cathelicidin antimicrobial peptide, in human gingival/oral epithelial cells. A human gingival epithelial cell line (Ca9-22) and human oral epithelial cell lines (HSC-2, HSC-3, and HSC-4) exhibited the enhanced expression of LL-37 mRNA upon stimulation with OCT as well as active metabolites of vitamins D3 and D2. Among the human epithelial cell lines, Ca9-22 exhibited the strongest response to these vitamin D-related compounds. OCT induced the higher production of CAP-18 (ng/mL order) until 6 days time-dependently in Ca9-22 cells in culture. The periodontal pathogen Porphyromonas gingivalis was killed by treatment with the LL-37 peptide. These findings suggest that OCT induces the production of hCAP-18/LL-37 in a manner similar to that induced by the active metabolite of vitamin D3.

  6. I'll Save the World from Global Warming--Tomorrow: Using Procrastination Management to Combat Global Warming

    Science.gov (United States)

    Malott, Richard W.

    2010-01-01

    In the provocatively titled "I'll Save the World from Global Warming--Tomorrow," Dick Malott says that although we all want to do the right thing to help the environment, whether it's buying and installing compact fluorescent light bulbs (CFLs) or replacing an energy-guzzling appliance with a more efficient one, we put it off because there's no…

  7. Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infections

    DEFF Research Database (Denmark)

    Nielsen, Karen L; Dynesen, Pia; Larsen, Preben

    2014-01-01

    Cathelicidin (LL-37) and human β-defensin 1 (hBD-1) are important components of the innate defense in the urinary tract. The aim of this study was to characterize whether these peptides are important for developing uncomplicated Escherichia coli urinary tract infections (UTIs). This was investiga......Cathelicidin (LL-37) and human β-defensin 1 (hBD-1) are important components of the innate defense in the urinary tract. The aim of this study was to characterize whether these peptides are important for developing uncomplicated Escherichia coli urinary tract infections (UTIs......). This was investigated by comparing urinary peptide levels of UTI patients during and after infection to those of controls, as well as characterizing the fecal flora of participants with respect to susceptibility to LL-37 and in vivo virulence. Forty-seven UTI patients and 50 controls who had never had a UTI were...... included. Participants were otherwise healthy, premenopausal, adult women. LL-37 MIC levels were compared for fecal E. coli clones from patients and controls and were also compared based on phylotypes (A, B1, B2, and D). In vivo virulence was investigated in the murine UTI model by use of selected fecal...

  8. Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells

    NARCIS (Netherlands)

    Liu, Quan; Liu, Juan; Roschmann, Kristina Irene Lisolette; van Egmond, Danielle; Golebski, Korneliusz; Fokkens, Wytske Johanna; Wang, Dehui; van Drunen, Cornelis Maria

    2013-01-01

    HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely

  9. Adjuvant and immunostimulatory effects of a D-galactose-binding lectin from Synadenium carinatum latex (ScLL in the mouse model of vaccination against neosporosis

    Directory of Open Access Journals (Sweden)

    Cardoso Mariana R D

    2012-10-01

    Full Text Available Abstract Vaccination is an important control measure for neosporosis that is caused by a coccidian parasite, Neospora caninum, leading to abortion and reproductive disorders in cattle and serious economic impacts worldwide. A D-galactose-binding lectin from Synadenium carinatum latex (ScLL was recently described by our group with potential immunostimulatory and adjuvant effects in the leishmaniasis model. In this study, we evaluated the adjuvant effect of ScLL in immunization of mice against neosporosis. First, we investigated in vitro cytokine production by dendritic cells stimulated with Neospora lysate antigen (NLA, ScLL or both. Each treatment induced TNF-α, IL-6, IL-10 and IL-12 production in a dose-dependent manner, with synergistic effect of NLA plus ScLL. Next, four groups of C57BL/6 mice were immunized with NLA + ScLL, NLA, ScLL or PBS. The kinetics of antibody response showed a predominance of IgG and IgG1 for NLA + ScLL group, whereas IgG2a response was similar between NLA + ScLL and NLA groups. Ex vivo cytokine production by mouse spleen cells showed the highest IFN-γ/IL-10 ratio in the presence of NLA stimulation for mice immunized with NLA + ScLL and the lowest for those immunized with ScLL alone. After parasite challenge, mice immunized with NLA + ScLL or ScLL alone presented higher survival rates (70-80% and lower brain parasite burden as compared to PBS group, but with no significant changes in morbidity and inflammation scores. In conclusion, ScLL combined with NLA was able to change the cytokine profile induced by the antigen or lectin alone for a Th1-biased immune response, resulting in high protection of mice challenged with the parasite, but with low degree of inflammation. Both features may be important to prevent congenital neosporosis, since protection and low inflammatory response are necessary events to guide towards a successful pregnancy.

  10. Pseudo-scalar Higgs boson production at N"3LO_A+N"3LL"'

    International Nuclear Information System (INIS)

    Ahmed, Taushif; Rana, Narayan; Ravindran, V.; Bonvini, Marco; Rottoli, Luca; Kumar, M.C.; Mathews, Prakash

    2016-01-01

    We consider the production of a pseudo-scalar particle A at the LHC, and present accurate theoretical predictions for its inclusive cross section in gluon fusion. The prediction is based on combining fixed-order perturbation theory and all-order threshold resummation. At fixed order we include the exact next-to-next-to-leading order (NNLO) plus an approximate next-to-next-to-next-to-leading order (N"3LO_A) which is based on the recent computation at this order for the scalar case. We then add threshold resummation at next-to-next-to-next-to leading logarithmic accuracy (N"3LL"'). Various forms of threshold resummation are considered, differing by the treatment of subleading terms, allowing a robust estimate of the theoretical uncertainties due to missing higher orders. With particular attention to pseudo-scalar masses of 200 and 750 GeV, we also observe that perturbative convergence is much improved when resummation is included. Additionally, results obtained with threshold resummation in direct QCD are compared with analogous results as computed in soft-collinear effective theory, which turn out to be in good agreement. We provide precise predictions for pseudo-scalar inclusive cross section at 13 TeV LHC for a wide range of masses. The results are available through updated versions of the public codes ggHiggs and TROLL. (orig.)

  11. Anatomia da madeira de Phyllanthus sellowianus Müll. Arg. (Phyllanthaceae

    Directory of Open Access Journals (Sweden)

    Luciano Denardi

    2013-01-01

    Full Text Available The present study aimed to describe the wood anatomy of Phyllanthus sellowianus Müll. Arg.(Phyllanthaceae, as well as the research of anatomical characters associated with the flexibility of their stems, desirable characteristic for bioengineering works. Belonging to the group of reophyllous and with up to three meters in height, the species occurs naturally in the south of Brazil, Uruguay and Argentina. The exsicat and wood sample from a P. sellowianus, located in the municipality of Santa Maria, Rio Grande do Sul state, Brazi, were deposited in the University Federal de Santa Maria under the numbers HDCF 5587 e 5588. Standard technique was used to set the histological lamina of wood. For macerations used the method of Jeffrey. The Wood anatomy description followed the IAWA Committee (1989. The microscopic analysis revealed the presence vassels of small diameter (< 60µm, radial multiples of 2 to 4 units, and simple perforation plates, obliquely, axial parenchyma absent, heterogeneous rays, with 1-3 cells large, and gelatinous fibers. The absence of axial parenchyma and laticifer tubes is compatible to the Phyllanthaceae group. The presence of perforated ray cells is, probably, the main anatomic component for differentiation of P. sellowianus from the other species of the genera. The abundant presence of gelatinous fibers certainly is one of the main anatomical characteristics related to the high flexibility of its stem.

  12. Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells.

    Science.gov (United States)

    Liu, Quan; Liu, Juan; Roschmann, Kristina Irene Lisolette; van Egmond, Danielle; Golebski, Korneliusz; Fokkens, Wytske Johanna; Wang, Dehui; van Drunen, Cornelis Maria

    2013-04-11

    HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely unknown. Therefore, we investigated the effects of two non-selective HDACi, trichostatin A (TSA) and sodium butyrate (SB), on the expression of the cathelicidin LL-37 in human airway epithelial cells. LL37 in human NCI-H292 airway epithelial cells and the primary cultures of normal nasal epithelial cells(PNEC) in response to HDAC inhibitors with or without poly (I:C) stimulation was assessed using real-time PCR and western blot. In parallel, IL-6 expression was evaluated by ELISA. Our results showed that HDAC inhibitors up-regulated LL-37 gene expression independent of poly (I:C) stimulation in PNEC as well as in NCI-H292 cells. HDAC inhibitors increased LL37 protein expression in NCI-H292 cells but not in PNEC. In addition, HDAC inhibitors significantly inhibited poly (I:C)-induced IL-6 production in both of the epithelial cells. In conclusion, HDAC inhibitors directly up-regulated LL-37 gene expression in human airway epithelial cells.

  13. Ulex europaeus Lektininin Kan Grubu Bağlama Özgüllüğü

    OpenAIRE

    ATEŞ, Ali; ÖZGÜR, Yeşim

    2002-01-01

    Bu çalışmada, Ulex europaeus bitkisinden elde edilen Ulex europaeus Aglutinin-I (UEA-I)’in insan kan grubu bağlama özgüllüğü ölçüldü. Bu deney için U tabanlı mikrotitrasyon kabı kullanıldı. 50µg/ml lektin çözeltisi, PBS (phosphate buffered saline) ile hazırlanarak başlangıç konsantrasyonu olarak alındı ve UEA-I’in seri sulandırılması ile insan kan grubu özgüllüğü belirlendi. Sonuç olarak, UEA-I’in %2’lik A grubu eritrositlerini 25µg/ml konsantrasyonda, B grubu eritrositlerini 6.25µg/ml konsan...

  14. Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo.

    Science.gov (United States)

    Durnaś, Bonita; Piktel, Ewelina; Wątek, Marzena; Wollny, Tomasz; Góźdź, Stanisław; Smok-Kalwat, Jolanta; Niemirowicz, Katarzyna; Savage, Paul B; Bucki, Robert

    2017-07-26

    Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials. We tested the in vitro activity of ceragenins CSA-13 and CSA-131 against several anaerobic bacteria including Bacteroides spp. and Clostridium difficile. We compared results to the activity of cathelicidin LL-37, metronidazole and nanosystems developed by attachment of CSA-13 and CSA-131 to magnetic nanoparticles (MNPs). The antibacterial effect was tested using killing assay and modified CLSI broth microdilution assay. Ceragenins CSA-13 and CSA-131 displayed stronger bactericidal activity than LL-37 or metronidazole against all of the tested bacterial strains. Additionally CSA-131 revealed an enhanced ability to prevent the formation of Bacteroides fragilis and Propionibacterium acnes biofilms. These data confirmed that ceragenins display antimicrobial activity against a broad range of microorganisms including anaerobic bacteria and deserve further investigations as compounds serving to develop new treatment against anaerobic and mixed infections.

  15. Cathelicidin (LL-37) and its correlation with pro-oxidant, antioxidant balance and disease activity in systemic lupus erythematosus: a cross-sectional human study.

    Science.gov (United States)

    Sahebari, M; Roshandel, G; Saadati, N; Saghafi, M; Abdolahi, N; Rezaieyazdi, Z

    2017-08-01

    Background Cathelicidin (LL-37), an endogenous antimicrobial peptide, has recently been involved in the pathogenesis of autoimmune diseases. To assess whether LL-37 reflects disease activity, we measured serum levels of it in systemic lupus erythematosus (SLE) patients with active and inactive disease compared to healthy controls. LL-37 was also compared between new and old cases. Moreover, the correlation of LL-37 and pro-oxidant, antioxidant balance (PAB) was measured. Methods The study population consisted of 50 SLE patients and 28 healthy controls. Of those, 39 patients had active and 11 patients had inactive disease. Serum levels of LL-37 were measured by ELISA and PAB values by a special method. Results There was no difference in levels of LL-37 between patients and healthy controls (50.9 ± 20.8 vs. 67.7 ± 43.3 ng/ml, P = 0.31). LL-37 did not correlate with SLEDAI and its items in total patients. LL-37 had a positive correlation with SLEDAI in active patients ( P = 0.01, r = 0.4). In active patients (78% of patients), multivariate regression analysis showed significant negative correlation between LL-37 and C3 ( P = 0.01, standardized beta -0.50). No difference was found in levels of PAB between patients and controls (90.4 ± 34.1 vs. 86.9 ± 25.6 HK, P = 0.4).There was no difference in the levels of PAB between patients with active and inactive disease (93.2 ± 34.1 vs. 80.2 ± 33.7 HK, P = 0.27). No correlation was found between levels of PAB and SLEDAI items and total score. However, a positive correlation between the levels of LL-37 and PAB in SLE patients was found ( r = 0.3, P lupus compared with healthy individuals. LL-37 serum values rose in parallel with SLEDAI in active disease. Positive correlation between serum PAB and LL-37 could be a great achievement of this study that may suggest the role of antioxidants in controlling NETosis.

  16. Measurement of the spin-spin correlation parameter C/sub LL/(THETA) in proton-proton scattering

    International Nuclear Information System (INIS)

    Stuart, S.J.

    1982-08-01

    The experimental procedures and methods of data analysis used to measure the spin-spin correlation parameter C/sub LL/(THETA) in proton-proton scattering at thirteen different energies in the range 300 to 800 MeV are presented. The results compare favorably with previous data. Good agreement is found with phase shift predictions at energies below 500 MeV

  17. The (re)-introduction of semiotics into medical education: on the works of Thure von Uexküll.

    Science.gov (United States)

    Tredinnick-Rowe, John

    2017-03-01

    Thure von Uexküll's reputation as a pioneer in biosemiotics and also in psychosomatic medicine is well documented. It is easy to see these disciplines reflected in his notable publications, both in English and in German. However, if one spares the time to filter through all of his articles, monographs, conference papers and editorials in English and in German, a notable gap arises in his English language publications: that of clinical education. This gap in the English language literature may seem unimportant in and of itself, but it speaks volumes when we consider the total absence of medical semiotics in the curriculum of medical schools in the English speaking world. This runs in stark contrast to the strong traditions of psychosomatic medicine in Germany, which Thure von Uexküll largely helped to instil. Do the works of Thure von Uexküll offer a possible step towards a resurrection of medical semiotics in clinical education? This chapter attempts to explore the lesser known German literature on clinical education that Thure von Uexküll produced, and explore the role semiotics can play in Medical Education in the English speaking world. While also seeking to contrast this literature with other existing approaches in British and American medical schools who have attempted to reintroduce medical humanities and reflexive thinking into clinical education. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  18. Sikap Masyarakat Surabaya terhadap Iklan AirAsia “We'll Take You There” di Televisi

    OpenAIRE

    Mahesthi, Athanasia Placidia

    2017-01-01

    Selama tahun 2015, AirAsia mengeluarkan sebanyak 8 iklan komersial di televisi, 2 diantaranya merupakan iklan yang memiliki tema berbeda daripada iklan televisi Low Cost Carier pada umumnya. Salah satu iklan televisi AirAsia adalah iklan “We'll Take You There” yang dirilis pada tanggal 1 November 2015 di berbagai stasiun televisi. Iklan ini terdiri dari beberapa penggalan cerita yang diperagakan oleh talent dari berbagai kalangan usia. Iklan ini memiliki pesan iklan bahwa AirAsia akan mengant...

  19. Prokaryotic Selectivity, Anti-endotoxic Activity and Protease Stability of Diastereomeric and Enantiomeric Analogs of Human Antimicrobial Peptide LL-37

    International Nuclear Information System (INIS)

    Nan, Yong Hai; Lee, Bongju; Shin, Song Yub

    2012-01-01

    LL-37 is the only antimicrobial peptide (AMP) of the human cathelicidin family. In addition to potent antimicrobial activity, LL-37 is known to have the potential to inhibit lipolysaccharide (LPS)-induced endotoxic effects. To provide the stability to proteolytic digestion and increase prokaryotic selectivity and/or anti-endotoxic activity of two Lys/Trp-substituted 19-meric anti-microbial peptides (a4-W1 and a4-W2) designed from IG-19 (residues 13-31 of LL-37), we synthesized the diastereomeric peptides (a4-W1-D and a4-W2-D) with D-amino acid substitution at positions 3, 7, 10, 13 and 17 of a4-W1 and a4-W2, respectively and the enantiomeric peptides (a4-W1-E and a4-W2-E) composed D-amino acids. The diastereomeric peptides exhibited the best prokaryotic selectivity and effective protease stability, but no or less anti-endotoxic activity. In contrast, the enantiomeric peptides had not only prokaryotic selectivity and anti-endotoxic activity but also protease stability. Our results suggest that the hydrophobicity and α-helicity of the peptide is important for anti-endotoxic activity. In particular, the enantiomeric peptides showed potent anti-endotoxic and LPS-neutralizing activities comparable to that of LL-37. Taken together, both a4-W1-E and a4-W2-E holds promise as a template for the development of peptide antibiotics for the treatment of endotoxic shock and sepsis

  20. Prokaryotic Selectivity, Anti-endotoxic Activity and Protease Stability of Diastereomeric and Enantiomeric Analogs of Human Antimicrobial Peptide LL-37

    Energy Technology Data Exchange (ETDEWEB)

    Nan, Yong Hai; Lee, Bongju; Shin, Song Yub [Chosun Univ., Gwangju (Korea, Republic of)

    2012-09-15

    LL-37 is the only antimicrobial peptide (AMP) of the human cathelicidin family. In addition to potent antimicrobial activity, LL-37 is known to have the potential to inhibit lipolysaccharide (LPS)-induced endotoxic effects. To provide the stability to proteolytic digestion and increase prokaryotic selectivity and/or anti-endotoxic activity of two Lys/Trp-substituted 19-meric anti-microbial peptides (a4-W1 and a4-W2) designed from IG-19 (residues 13-31 of LL-37), we synthesized the diastereomeric peptides (a4-W1-D and a4-W2-D) with D-amino acid substitution at positions 3, 7, 10, 13 and 17 of a4-W1 and a4-W2, respectively and the enantiomeric peptides (a4-W1-E and a4-W2-E) composed D-amino acids. The diastereomeric peptides exhibited the best prokaryotic selectivity and effective protease stability, but no or less anti-endotoxic activity. In contrast, the enantiomeric peptides had not only prokaryotic selectivity and anti-endotoxic activity but also protease stability. Our results suggest that the hydrophobicity and α-helicity of the peptide is important for anti-endotoxic activity. In particular, the enantiomeric peptides showed potent anti-endotoxic and LPS-neutralizing activities comparable to that of LL-37. Taken together, both a4-W1-E and a4-W2-E holds promise as a template for the development of peptide antibiotics for the treatment of endotoxic shock and sepsis.

  1. The Effect of Calcipotriol on the Expression of Human β Defensin-2 and LL-37 in Cultured Human Keratinocytes

    Directory of Open Access Journals (Sweden)

    Beom Joon Kim

    2009-01-01

    Full Text Available Background. Vitamin D has been reported to regulate innate immunity by controlling the expression of antimicrobial peptides (AMPs. Objective. We investigated the effect of calcipotriol on the expression of AMPs in human cultured keratinocytes. Methods. Keratinocytes were treated with lipopolysaccharide (LPS, TNF-α, Calcipotriol and irradiated with UVB, cultured, and harvested. To assess the expression of human beta defensin-2 and LL-37 in the control group, not exposed to any stimulants, the experimental group was treated with LPS, TNF-α, or UVB, and another group was treated again with calcipotriol; reverse transcriptase-polymerase chain reaction, Western blotting, and immunohistochemical staining were performed. Results. In the experimental group treated with LPS, UVB irradiation, and TNF-α, the expression of β-defensin and LL-37 was increased more than in the control group and then decreased in the experimental group treated with calcipotriol. Conclusions. Calcipotriol suppressed HBD-2 and LL-37, which were stimulated by UVB, LPS, and TNF-α.

  2. An ll-Diaminopimelate Aminotransferase Defines a Novel Variant of the Lysine Biosynthesis Pathway in Plants1[W

    Science.gov (United States)

    Hudson, André O.; Singh, Bijay K.; Leustek, Thomas; Gilvarg, Charles

    2006-01-01

    Although lysine (Lys) biosynthesis in plants is known to occur by way of a pathway that utilizes diaminopimelic acid (DAP) as a central intermediate, the available evidence suggests that none of the known DAP-pathway variants found in nature occur in plants. A new Lys biosynthesis pathway has been identified in Arabidopsis (Arabidopsis thaliana) that utilizes a novel transaminase that specifically catalyzes the interconversion of tetrahydrodipicolinate and ll-diaminopimelate, a reaction requiring three enzymes in the DAP-pathway variant found in Escherichia coli. The ll-DAP aminotransferase encoded by locus At4g33680 was able to complement the dapD and dapE mutants of E. coli. This result, in conjunction with the kinetic properties and substrate specificity of the enzyme, indicated that ll-DAP aminotransferase functions in the Lys biosynthetic direction under in vivo conditions. Orthologs of At4g33680 were identified in all the cyanobacterial species whose genomes have been sequenced. The Synechocystis sp. ortholog encoded by locus sll0480 showed the same functional properties as At4g33680. These results demonstrate that the Lys biosynthesis pathway in plants and cyanobacteria is distinct from the pathways that have so far been defined in microorganisms. PMID:16361515

  3. Portrait of Gunnar Källén a physics shooting star and poet of early quantum field theory

    CERN Document Server

    2014-01-01

    Wolfgang Pauli referred to him as 'my discovery,' Robert Oppenheimer described him as 'one of the most gifted theorists' and Niels Bohr found him enormously stimulating. Who was the man in question, Gunnar Källén (1926-1968)? His appearance in the physics sky was like a shooting star. His contributions to the scientific debate caused excitement among young and old. Similar to his friend and mentor, Wolfgang Pauli, he demanded honesty and rigor in physics - a distinct dividing line between fact and speculation. In his obituary, Arthur S. Wightman would write: 'Gunnar Källén was a proud continuer of the tradition in quantum field theory established by Wolfgang Pauli. His papers on quantum electrodynamics in the period 1950-1954 carried the non-perturbative approach to quantum electrodynamics forward to a point beyond which very little essential progress has been made up to the present day. At the time I was trying to puzzle out the grammar of the language of quantum field theory, and here was Källén al...

  4. Pharmacobotanic characterization of young stems and stem barks of Rauvolfia sellowii Müll. Arg., Apocynaceae

    Directory of Open Access Journals (Sweden)

    Leopoldo Clemente Baratto

    2010-09-01

    Full Text Available Rauvolfia sellowii Müll. Arg. (Apocynaceae, a Brazilian native tree rich in indole alkaloids, is known as "pau-pra-tudo" and popularly used as hypocholesterolemic, hypoglycemic and antihypertensive. The aim of this work was to study the anatomy of the young stems and stem barks of this medicinal plant, in order to contribute to the identification of the species as a drug. The plant material was fixed and prepared according to standard microtechniques. The young stems have remaining epidermis, but a suberified peridermis is evident. The phellogen is located in the cortical region, forming suber externally. Underneath the phellogen, lies the phelloderm and collenchymatic region. In the cortex, there are numerous laticifers and some fibers. There is an incomplete sclerenchymatic sheath, consisting of several groups of fibers and stone cells. The stem has internal phloem ordered as isolated groups side by side. Numerous laticifers, calcium oxalate crystals, idioblasts and amyloplasts are found in the cortex, phloem, xylem and pith. The stem bark has many layers of suber and cortical parenchyma, a sheath composed of fibers and stone cells totally lignified, and external phloem. These anatomical characteristic, taken together, can be used as quality control parameters for this species.Rauvolfia sellowii Müll. Arg. (Apocynaceae, uma árvore nativa brasileira rica em alcaloides indólicos, é conhecida como "pau-pra-tudo" e utilizada popularmente como hipocolesterolêmica, hipoglicêmica e anti-hipertensiva. O presente trabalho teve como objetivo caracterizar anatomicamente o caule jovem e a casca caulinar dessa planta medicinal, a fim de contribuir para a identificação e autenticidade da droga. O material vegetal foi fixado e submetido às microtécnicas usuais. O caule jovem possui epiderme remanescente, porém uma periderme suberificada é observada. O felogênio instala-se na região cortical, formando súber externamente. Subjacentes ao felog

  5. The Storage Stability of Anthocyanins in Mao (Antidesma thwaitesianum Müll. Arg. Juice and Concentrate

    Directory of Open Access Journals (Sweden)

    Prommakool Arunya

    2016-01-01

    Full Text Available Mao or Makmao (Antidesma thwaitesianum Müll. Arg. is a wild plant found in the northeast of Thailand. Mao is one of fruits which are source of anthocyanins. Mao fruits are used for juice and concentrate which are consumed for healthy drinks. Determination of the kinetic parameters is essential to predict the quality changes and stability of anthocyanins in Mao juice and concentrate that occur during storage. The purpose of this research was to study the degradation of anthocyanins in Mao juice and concentrate during storage at 5, 30 and 37°C for 15 days. The storage stability of Mao anthocyanins was studied in 15°Brix juice and 45°Brix concentrate. The degradation kinetic (k, half-life (t1/2, activation energy (Ea and Q10 values for Mao anthocyanins degradation were determined. The results indicated that analysis of kinetic data for the degradation of anthocyanins followed a first-order reaction. An increase storage temperature from 5 to 30 and 37°C increased k value of anthocyanins in Mao juice and concentrate. Increasing storage temperature decreased t1/2 value of anthocyanins in both concentrations. At 5, 30 and 37°C, the t1/2 of anthocyanins decreased from 35 to 13 and 5 days for Mao juice and 32 to 25 and 21 days for Mao concentrate. The Ea value of the anthocyanins degradation in Mao juice and concentrate were 38.03 and 8.42 kJ/mol, respectively. Q10 values of both Mao juice and concentrate at 30-37°C were higher than those were storaged at 5-30°C. Thus higher stability of anthocyanins was achieved by using concentration and storage at lower temperature.

  6. Laxative activities of Mareya micrantha (Benth. Müll. Arg. (Euphorbiaceae leaf aqueous extract in rats

    Directory of Open Access Journals (Sweden)

    Djaman Joseph A

    2010-02-01

    Full Text Available Abstract Background Mareya micrantha (Benth. Müll. Arg. (Euphorbiaceae is a shrub that is commonly used in Côte d'Ivoire (West Africa for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Methods Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w., per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o., produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o. was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o. The same doses of the extract (200 and 400 mg/kg, p.o. produced a significant increase (p -, Na+, K+ and Ca2+ in the intestinal fluid (p Conclusions The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.

  7. [Effects of antimicrobial peptide LL-37 expressed and purified from prokaryotes in the murine model of vaginal candidiasis].

    Science.gov (United States)

    Wang, F; Huo, Y; Yin, L R; Sun, B; Zhang, P P

    2016-07-25

    To study the effects of antimicrobial peptide LL-37 expressed and purified from prokaryotes on candida albicans growth. (1)Thirty female Kunming mice were treated with estrogen and white candida yeast suspension were poured into vagina to establish a vulvovaginal candidiasis(VVC)murine model. After successful establishing the VVC mouse model, mice were randomly sorted into test group(n=15)and control group(n=15). Suspension(30 μl, 100 μg/ml)of recombinant peptide LL-37 expressed and purified in Prokaryotes was given by intravaginal administration to the test group for 5 days, while the same amount of phosphate buffered saline(PBS)was given to the control group.(2)Tweenty-four hours after treatment, the fungal burden and colony-forming unit(CFU)of vaginal fluids were evaluated. All mice were subsequently sacrificed and vaginal tissues were harvested for tissue homogenate preparation. ELISA was used to determine the levels of nterleukin-10(IL-10)and interferon-γ(IFN-γ)in the isolated vaginal tissues. (1)VVC mouse model was established successfully in this study. Vaginal mucosa congestion, edema, vaginal plica disappearing were obviously observed in the control group. After treatment with recombinant protein LL-37 vaginal mucosa has no obvious change in the test group.(2)Fungal burden and CFU of vaginal fluids were significantly lower in the test group [(4.8±1.0)×10(4) CFU/ml]than that in the control group [(8.5±2.1)×10(4) CFU/ml, P=0.017]. IFN-γ level of the test group was increased [(257±11)vs(197±4)pg/ml, P=0.000], while the level of IL-10 was reduced [(287 ± 15)vs(379 ± 17)pg/ml P=0.000] resulting in a the ratio of IFN-γ/IL-10 was in significantly higher in test group(0.892±0.008 vs 0.496±0.013, P=0.000). Recombinant protein LL-37 expressed and purified from prokaryotes inhibits the growth candida albicans and improves vaginal immunity by adjusting IFN-γ and IL-10 secretion in the VVC mouse model, highlighting the therapeutic potential of LL-37

  8. First results for the two-spin parameter A sub LL in. pi. sup 0 production by 200 GeV polarized protons and antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D L; Corcoran, M D; Cranshaw, J; Nessi-Tedaldi, F; Nessi, M; Nguyen, C; Roberts, J B; Skeens, J; White, J L [Rice Univ., Houston, TX (USA). Bonner Nuclear Labs.; Akchurin, N; Onel, Y [Iowa Univ., Iowa City (USA). Dept. of Physics and Astronomy; Belikov, N I; Derevschikov, A A; Grachov, O A; Matulenko, Yu A; Meschanin, A P; Nurushev, S B; Patalakha, D I; Rykov, V L; Solovyanov, V L; Vasiliev, A N [Institut Fiziki Vysokikh Ehnergij, Serpukhov (USSR); Bystricky, J; Chaumette, P; Deregel, J; Durand, G; Fabre, J; Lehar, F; Lesquen, A de [CEA Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France); Cossairt, J D; Read, A L [Fermi National Accelerator Lab., Batavia, IL (USA); En' yo, H; Funahashi, H; Goto, Y; Imai, K; Itow, Y; Makino, S; Masaike, A; Miyake, K; Nagamine, T; Saito, N; Yamashita, S [Kyoto Univ. (Japan). Dept. of Physics; Fukuda, K [Meiji Coll. of Oriental Medicine, Kyoto (Japan); Grosnick, D P; Hill, D A; FNAL E581/704 Collaboration

    1991-05-23

    The two-spin parameter A{sub LL} in inclusive {pi}{sup 0} production by longitudinally-polarized protons and antiprotons on a longitudinally-polarized proton target has been measured at the 200 GeV Fermilab spin physics facility, for {pi}{sup 0}'s at x{sub F} = 0 with 1 {le} p{sub t} {le} 3 GeV/c. The results exclude, at the 95% confidence level, values of A{sub LL} (pp) > 0.1 and < -0.1, for {pi}{sup 0}'s produced by protons, and values of A{sub LL} (anti pp) > 0.1 and < -0.2 for incident antiprotons. The relevance of A{sub LL}(pp) for the gluon spin density is discussed. The data are in good agreement with 'conventional' small or zero, gluon polarization. (orig.).

  9. Energy dependence of Lα-to-Ll x-ray intensity ratios for Yb and Pb produced by heavy-ion bombardment

    International Nuclear Information System (INIS)

    Gray, T.J.

    1980-01-01

    Measurements of the incident-ion energy dependence of Lα-to-Ll x-ray intensity ratios are reported for protons incident at 0.40 to 2.20 MeV/amu on thin targets of Pb and for 4 He and C ions incident upon Yb. The data are compared to calculations of the Lα-to-Ll ratio which include the effects of alignment of the 2p/sub 3/2/ state of the target

  10. LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity.

    Science.gov (United States)

    Rajasekaran, Ganesan; Kim, Eun Young; Shin, Song Yub

    2017-05-01

    Although the human-derived antimicrobial peptide (AMP) LL-37 has potent antimicrobial and anti-inflammatory activities, its therapeutic application is limited by its low cell selectivity and high production cost due to its large size. To overcome these problems, we tried to develop novel LL-37-derived short α-helical AMPs with improved cell selectivity and without a significant loss of anti-inflammatory activity relative to that of parental LL-37. Using amino acid substitution, we designed and synthesized a series of FK13 analogs based on the sequence of the 13-meric short FK13 peptide (residues 17-29 of LL-37) that has been identified as the region responsible for the antimicrobial activity of LL-37. Among the designed FK13 analogs, FK-13-a1 and FK-13-a7 showed high cell selectivity and retained the anti-inflammatory activity. The therapeutic index (a measure of cell selectivity) of FK-13-a1 and FK-13-a7 was 6.3- and 2.3-fold that of parental LL-37, respectively. Furthermore, FK-13-a1 and FK-13-a7 displayed more potent antimicrobial activity against antibiotic-resistant bacteria including MRSA, MDRPA, and VREF, than did LL-37. In addition, FK-13-a1 and FK-13-a7 exhibited greater synergistic effects with chloramphenicol against MRSA and MDRPA and were more effective anti-biofilm agents against MDRPA than LL-37 was. Moreover, FK-13-a1 and FK-13-a7 maintained their activities in the presence of physiological salts and human serum. SYTOX green uptake, membrane depolarization and killing kinetics revealed that FK13-a1 and FK13-a7 kills microbial cells by permeabilizing the cell membrane and damaging membrane integrity. Taken together, our results suggest that FK13-a1 and FK13-a7 can be developed as novel antimicrobial/anti-inflammatory agents. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. The extracellular phage-host interactions involved in the bacteriophage LL-H infection of Lactobacillus delbrueckii ssp. lactis ATCC 15808.

    Science.gov (United States)

    Munsch-Alatossava, Patricia; Alatossava, Tapani

    2013-12-24

    The complete genome sequence of Lactobacillus bacteriophage LL-H was determined in 1996. Accordingly, LL-H has been used as a model phage for the infection of dairy Lactobacillus, specifically for thermophilic Lactobacillus delbrueckii ssp. lactis host strains, such as ATCC 15808. One of the major goals of phage LL-H research consisted of the characterization of the first phage-host interactions at the level of phage adsorption and phage DNA injection steps to determine effective and practical methods to minimize the risks associated with the appearance and attack of phages in the manufacture of yogurt, and Swiss or Italian hard type cheeses, which typically use thermophilic lactic acid bacteria starter cultures containing L. delbrueckii strains among others. This mini review article summarizes the present data concerning (i) the special features, particle structure, and components of phage LL-H and (ii) the structure and properties of lipoteichoic acids (LTAs), which are the phage LL-H receptor components of L. delbrueckii ssp. lactis host strains. Moreover, a model of the first, extracellular, phage-host interactions for the infection of L. delbrueckii ssp. lactis ATCC 15808 by phage LL-H is presented and further discussed.

  12. The extracellular phage-host interactions involved in the bacteriophage LL-H infection of Lactobacillus delbrueckii ssp. lactis ATCC 15808

    Directory of Open Access Journals (Sweden)

    Patricia eMunsch-Alatossava

    2013-12-01

    Full Text Available The complete genome sequence of Lactobacillus bacteriophage LL-H was determined in 1996. Accordingly, LL-H has been used as a model phage for the infection of dairy Lactobacillus, specifically for thermophilic Lb. delbrueckii ssp. lactis host strains, such as ATCC 15808. One of the major goals of phage LL-H research consisted of the characterization of the the first phage-host interactions at the level of phage adsorption and phage DNA injection steps to determine effective and practical methods to minimise the risks associated with the appearance and attack of phages in the manufacture of yoghurt, and Swiss or Italian type hard cheeses, which typically use thermophilic LAB starter cultures containing Lb. delbrueckii strains among others. This mini review article summarises the present data concerning (i the special features, particle structure and components of phage LL-H and (ii the structure and properties of lipoteichoic acids (LTAs, which are the phage LL-H receptor components of Lb. delbrueckii ssp. lactis host strains. Moreover, a model of the first, extracellular, phage-host interactions for the infection of Lb. delbrueckii ssp. lactis ATCC 15808 by phage LL-H is presented and further discussed.

  13. Architecture Design Issues of a Reversible Deep Geological Repository for HL and IL/LL Waste

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, C.; Londe, L.; Poisson, J.B. [Andra (France)

    2009-06-15

    In accordance with the Planning Act of 28 June 2006, the French National Radioactive Waste Management Agency (Agence nationale pour la gestion des dechets radioactifs - ANDRA) is currently investigating the possibility of disposing of high-level (HL) and intermediate-level long-lived (IL/LL) radioactive waste in a deep geological formation. The waste inventory intended for geological disposal is significant and represents approximately 80,000 m{sup 3} of primary waste. The required drifts and cells for such disposal are developing in a long and complex network, with plans calling for a total of about 300 km of drifts to be opened over the next century. This paper describes various issues relating to the architecture design and the way they are integrated. Long-term safety is at the basis of the major principles not only for dividing the different waste categories into separate disposal areas, but also for identifying the relevant constraints involving the topology of the network (fragmentation of disposal areas into modules, dead-end architecture) and the orientation of certain structures. In the case of exothermal waste, since the control over the phenomenological evolution also leads to selecting a thermal criterion in the geological layer in contact with the waste, there is an impact on the density of the repository and, consequently, on its architecture. Operational security and safety issues are reflected in ventilation needs and in personnel-evacuation requirements in case of fire, both of which require additional intersections and drifts. The section of drifts is also conditioned often by those security aspects. Nuclear zoning may also induce requirements for special structures having a potential impact on the architecture. Operation, taken into its broader sense encompassing construction and nuclear activities, imposes its own share of constraints quite independently from any security or safety considerations. Impacted areas include structure slopes, the

  14. A QCM-D study of the concentration- and time-dependent interactions of human LL37 with model mammalian lipid bilayers.

    Science.gov (United States)

    Lozeau, Lindsay D; Rolle, Marsha W; Camesano, Terri A

    2018-07-01

    The human antimicrobial peptide LL37 is promising as an alternative to antibiotics due to its biophysical interactions with charged bacterial lipids. However, its clinical potential is limited due to its interactions with zwitterionic mammalian lipids leading to cytotoxicity. Mechanistic insight into the LL37 interactions with mammalian lipids may enable rational design of less toxic LL37-based therapeutics. To this end, we studied concentration- and time-dependent interactions of LL37 with zwitterionic model phosphatidylcholine (PC) bilayers with quartz crystal microbalance with dissipation (QCM-D). LL37 mass adsorption and PC bilayer viscoelasticity changes were monitored by measuring changes in frequency (Δf) and dissipation (ΔD), respectively. The Voigt-Kelvin viscoelastic model was applied to Δf and ΔD to study changes in bilayer thickness and density with LL37 concentration. At low concentrations (0.10-1.00 μM), LL37 adsorbed onto bilayers in a concentration-dependent manner. Further analyses of Δf, ΔD and thickness revealed that peptide saturation on the bilayers was a threshold for interactions observed above 2.00 μM, interactions that were rapid, multi-step, and reached equilibrium in a concentration- and time-dependent manner. Based on these data, we proposed a model of stable transmembrane pore formation at 2.00-10.0 μM, or transition from a primarily lipid to a primarily protein film with a transmembrane pore formation intermediate state at concentrations of LL37 > 10 μM. The concentration-dependent interactions between LL37 and PC bilayers correlated with the observed concentration-dependent biological activities of LL37 (antimicrobial, immunomodulatory and non-cytotoxic at 0.1-1.0 μM, hemolytic and some cytotoxicity at 2.0-13 μM and cytotoxic at >13 μM). Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Response of clonogenic cells of mice solid tumour NKLy/LL to N-methyl-N-nitrosourea

    International Nuclear Information System (INIS)

    Chan Tik Kan; Afanas'ev, G.G.; Pelevina, I.I.

    1979-01-01

    By cloning in vitro the cells of NKLy/LL solid tumour of mice it has been shown that the curve of clonogenic cell survival versus N-methyl-N-nitrosourea (MNU) dose in the 12.5-200.0 mg/kg interval is exponential and characterized by Dsub(o)=29.15 mg/kg dose value. Large size tumours (15.0-17.0 g) are characterized by higher death rate of clonogenic cells (survivor fraction approximately 0.5%) than in 1.0-7.0 g tumours (survivor fraction 2-4%). That is, evidently, related to higher sensitivity of the resting tumour cells to MNU

  16. Uranium-lead Isotope Evidence in the Shelyabinsk LL5 Chondrite Meteorite for Ancient and Recent Thermal Events

    Science.gov (United States)

    Lapen, T. J.; Kring, D. A.; Zolensky, M. E.; Andreasen, R.; Righter, M.; Swindle, T. D.; Beard, S. P.; Swindle, T. D.

    2014-01-01

    The impact histories on chondrite parent bodies can be deduced from thermochronologic analyses of materials and isotope systems with distinct apparent closure temperatures. It is especially critical to better understand the geological histories and physical properties of potenally hazardous near-Earth asteroids. Chelyabinsk is an LL5 chondrite meteorite that was dispersed over a wide area tens of kilometers south of the town of Chelyabinsk, Russia by an explosion at an altitude of 27 km at 3:22 UT on 15 Feb 2013 [1,2]. The explosion resulted in significant damage to surrounding areas and over 1500 injuries along with meteorite fragments being spread over a wide area [1].

  17. TOWARDS SOCIOLOGY OF MUSIC: FROM THE SCIENTIFIC HERITAGE OF L.L. SABANEEV

    Directory of Open Access Journals (Sweden)

    V. G. Lukianov

    2017-01-01

    Full Text Available The author analyzes the ideas of L.L. Sabaneev (1881–1968 – Professor of Moscow University, a well-known Russian musicologist, music critic, pianist and composer who emigrated in 1926. His theoretical ideas remain almost unexplored. However, his works on the theory and history of music are still interesting: he substantiated the need of sociological approach to the study of music and the analysis of music in context of social life. Unlike his contemporaries, musicologists (A.V. Lunacharsky, B.V. Asafiev, R.I. Gruber, etc., who, although set the task of the development of the sociological approach, but did not implement it at once, Sabaneyev published his works on the history of music in the mid 20-ies, he tried to reveal this problem on the new methodological basis. The article shows that, Sabaneev suggested to renew the methodology of domestic musicology in the 20-ies of the XX century. Sabaneev developed a special conceptual apparatus (“production” and “consumption” of music, “the environment or the consumer of the musical arts”, “musical (sound consciousness”, “taste group”, “style” – individual, group, “school style”, “style of the epoch”, etc., by means of which he was able to realize the task of development of the sociological approach in musicology. There presented a statement that the introduction by Sabaneev such terms as “impression of the spirit”, “a type of feeling”, “world vision”, “musical vision”, “audible world perception”, “world outlook” in many ways anticipates the modern idea of picture of the world (which includes three components – world outlook, world perception and worldview, which finds its embodiment in the work of art. Sabaneev’s effort to present a typology of music listeners, which turned out to be innovative in its time became valuable for the present stage of sociology of music development. Much later T.W. Adorno put the

  18. Zerstören oder Bewahren? Umgang mit kulturellem Erbe bel H. Böll und E. Loest

    Directory of Open Access Journals (Sweden)

    Helmut Galle

    2003-12-01

    Full Text Available O artigo descreve e analisa como dois importantes autores de oposição intelectual na Alemanha Ocidental (Böll e Oriental (Loest reconstroem, cada um para sua sociedade, as atitudes dominantes frente ao patrimônio cultural e arquitetônico. Em cada caso, as atitudes das elites do poder diferem daquelas dos opositores: Na RFA, o governo, em geral, preserva os monumentos, fingindo uma continuidade histórica; na RDA, o governo destrói palácios e igrejas para romper com as tradições. Os autores simpatizam com os opositores: Böll, no oeste, enfatiza a necessidade de destruir o patrimônio cultural para recuperar a função memorativa do mesmo, enquanto Loest opta pela resistência contra a política oficial da destruição no leste. A preservação de monumentos históricos é vista, em ambos os casos, em função das necessidades da geração atual, não como valor em si mesmo.

  19. Liposakşın Yöntemiyle Jinekomasti Tedavisi: 8 Yıllık Deneyim

    OpenAIRE

    Çil, Yakup

    2015-01-01

    Amaç: Jinekomasti erkeklerde görülen patolojik meme büyüklüğünü olarak tanımlanmaktadır. Jinekomastinin temel tedavi yöntemi cerrahidir. Son yıllarda liposakşın yönteminde jinekomastinin cerrahi tedavisinde kullanılmaya başlanmıştır. Burada 8 yıllık dönemde liposakşın yöntemi ile tedavi edilen jinekomastili hastaların sonuçları sunuldu. Yöntem ve Gereçler: Çalışmada; 2006-2014 yılları arasındaki 8 yıllık dönemde jinekomasti nedeniyle liposakşın yöntemi ile tedavi edilen yaş ortalaması 23 yıl...

  20. Biochemical characterization of recombinant cinnamoyl CoA reductase 1 (Ll-CCRH1) from Leucaena leucocephala.

    Science.gov (United States)

    Sonawane, Prashant; Vishwakarma, Rishi Kishore; Khan, Bashir M

    2013-07-01

    Recombinant cinnamoyl CoA reductase 1 (Ll-CCRH1) protein from Leucaena leucocephala was overexpressed in Escherichia coli BL21 (DE3) strain and purified to apparent homogeneity. Optimum pH for forward and reverse reaction was found to be 6.5 and 7.8 respectively. The enzyme was most stable around pH 6.5 at 25°C for 90 min. The enzyme showed Kcat/Km for feruloyl, caffeoyl, sinapoyl, coumaroyl CoA, coniferaldehyde and sinapaldehyde as 4.6, 2.4, 2.3, 1.7, 1.9 and 1.2 (×10(6) M(-1) s(-1)), respectively, indicating affinity of enzyme for feruloyl CoA over other substrates and preference of reduction reaction over oxidation. Activation energy, Ea for various substrates was found to be in the range of 20-50 kJ/mol. Involvement of probable carboxylate ion, histidine, lysine or tyrosine at the active site of enzyme was predicted by pH activity profile. SAXS studies of protein showed radius 3.04 nm and volume 49.25 nm(3) with oblate ellipsoid shape. Finally, metal ion inhibition studies revealed that Ll-CCRH1 is a metal independent enzyme. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Physiologically-Relevant Modes of Membrane Interactions by the Human Antimicrobial Peptide, LL-37, Revealed by SFG Experiments

    Science.gov (United States)

    Ding, Bei; Soblosky, Lauren; Nguyen, Khoi; Geng, Junqing; Yu, Xinglong; Ramamoorthy, Ayyalusamy; Chen, Zhan

    2013-05-01

    Antimicrobial peptides (AMPs) could become the next generation antibiotic compounds which can overcome bacterial resistance by disrupting cell membranes and it is essential to determine the factors underlying its mechanism of action. Although high-resolution NMR and other biological studies have provided valuable insights, it has been a major challenge to follow the AMP-membrane interactions at physiologically-relevant low peptide concentrations. In this study, we demonstrate a novel approach to overcome this major limitation by performing Sum Frequency Generation (SFG) vibrational spectroscopic experiments on lipid bilayers containing an AMP, LL-37. Our results demonstrate the power of SFG to study non-linear helical peptides and also infer that lipid-peptide interaction and the peptide orientation depend on the lipid membrane composition. The observed SFG signal changes capture the aggregating process of LL-37 on membrane. In addition, our SFG results on cholesterol-containing lipid bilayers indicate the inhibition effect of cholesterol on peptide-induced membrane permeation process.

  2. Identification of Secreted Proteins Involved in Nonspecific dsRNA-Mediated Lutzomyia longipalpis LL5 Cell Antiviral Response

    Directory of Open Access Journals (Sweden)

    Andrea Martins-da-Silva

    2018-01-01

    Full Text Available Hematophagous insects transmit infectious diseases. Sand flies are vectors of leishmaniasis, but can also transmit viruses. We have been studying immune responses of Lutzomyia longipalpis, the main vector of visceral leishmaniasis in the Americas. We identified a non-specific antiviral response in L. longipalpis LL5 embryonic cells when treated with non-specific double-stranded RNAs (dsRNAs. This response is reminiscent of interferon response in mammals. We are investigating putative effectors for this antiviral response. Secreted molecules have been implicated in immune responses, including interferon-related responses. We conducted a mass spectrometry analysis of conditioned medium from LL5 cells 24 and 48 h after dsRNA or mock treatment. We identified 304 proteins. At 24 h, 19 proteins had an abundance equal or greater than 2-fold change, while the levels of 17 proteins were reduced when compared to control cells. At the 48 h time point, these numbers were 33 and 71, respectively. The two most abundant secreted peptides at 24 h in the dsRNA-transfected group were phospholipid scramblase, an interferon-inducible protein that mediates antiviral activity, and forskolin-binding protein (FKBP, a member of the immunophilin family, which mediates the effect of immunosuppressive drugs. The transcription profile of most candidates did not follow the pattern of secreted protein abundance.

  3. Regulation and function of the CD3¿ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro

    DEFF Research Database (Denmark)

    Dietrich, J; Kastrup, J; Nielsen, B L

    1997-01-01

    /CD3gamma chimeras; and in vitro by binding CD3gamma peptides to clathrin-coated vesicle adaptor proteins (APs). We find that the CD3gamma D127xxxLL131/132 sequence represents one united motif for binding of both AP-1 and AP-2, and that this motif functions as an active sorting motif in monomeric CD4...... and for AP binding in vitro. Furthermore, we provide evidence indicating that phosphorylation of CD3gamma S126 in the context of the complete TCR induces a conformational change that exposes the DxxxLL sequence for AP binding. Exposure of the DxxxLL motif causes an increase in the TCR internalization rate...

  4. "Alguses oli tema üksinda, sest oli küll..." : [luuletused] / Kabir ; tlk. Doris Kareva

    Index Scriptorium Estoniae

    Kabir

    2006-01-01

    Sisu: "Alguses oli tema üksinda, sest oli küll..." ; "Kõik loodud on Kõiksuse poolt..." ; "Otsid Sa mind?..." ; "Kabir oma meele puhtaks..." ; "Pole pühades järvedes midagi muud peale vee..." ; "Otsisin kelme ja kõveraid..." ; "Ütle, vend, mida küll teha..." ; "Mis kurja on teinud su juuksed..." ; "Ära tõuse, et minna õue vaatama lilli..." ; "Sinu sünd inimesena on küps vili..." ; "Öö saatsid sa magades mööda..." ; "Pole ma hindu..." ; "Ma vaatan sind..." ; "Veskikivisid vaadeldes ; "Nähes aednikku lähenemas, õhkasid pungad..." ; "Tasa, tasa tõtta, mu meel..." ; "Ära kurvasta..." ; "Imetlusväärne on teemant..." ; "Kuula, sõber, see keha on Tema lüüra..." ; "Nagu seemnes varjul on õli..." ; "Olgugi ookean leekides..." ; "Tilka, mis lahustub meres..." ; "Jõgi ja lained on üks..." ; "Kes sa oled ja kust oled tulnud?..." ; "Kaovad kuningad, kauneimad kuningannad..." ; "Rohkem kui midagi muud..." ; "Lihalik, surelik tantsib selle ees..." ; "Väike rubiin, mida igaüks ihkab..." ; "Mine heade juurde, kus Armastatugi elab..." ; "Eksitus sulgeb väravad..." ; "Keelilt vallandub helisid..." ; "Kõik algab lahusoleku valust..." ; "Ärka, sõber! Miks ikka veel magad?..." ; "Kuu on mu kehas, kuid ise ma seda ei näe..." ; "Miks oled nii kärsitu, süda?..." ; "Kellele kuulub see flööt..." ; "Kui raske on Külalist kohata!..." ; "Kandetool toodi minule järgi mu isakoju..." ; "Siia ilma sündides nutsid..." ; "Oh mu süda! Ei jõudnud sa tundma õppida..." ; "Õige kulunud on sinu rüü..." ; "Õhkõrn on see õhuke rüü..." ; "Lipp, mida keegi ei näe..." ; "Oh otsija, lihtne liit lähim on südamele..." ; "Õhtu varjud on sügavaks saanud..." ; "Kuis saakski katkeda armastus me kahe vahel..." ; "Luik, tahaksin, et mulle räägiksid kõik oma loo..." ; "Kuhu ihaled küll, minu süda?..." ; "Ei lakka Lõpmatu flöödiheli..." ; "Mida näed, seda pole...". Autori kohta eluloolisi andmeid lk. 11

  5. X-ray digital industrial radiography (DIR) for local liquid velocity (V{sub LL}) measurement in trickle bed reactors (TBRs): Validation of the technique

    Energy Technology Data Exchange (ETDEWEB)

    Mohd Salleh, Khairul Anuar, E-mail: kmfgf@mst.edu; Lee, Hyoung Koo [Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Fulton Hall, 310 W. 14th St., Rolla, Missouri 65409 (United States); Rahman, Mohd Fitri Abdul [Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 143 Schrenk Hall, 400 W. 11th St., Rolla, Missouri 65409 (United States); Al Dahhan, Muthanna H. [Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Fulton Hall, 310 W. 14th St., Rolla, Missouri 65409 (United States); Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 143 Schrenk Hall, 400 W. 11th St., Rolla, Missouri 65409 (United States)

    2014-06-15

    Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (V{sub LL}) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the V{sub LL} within TBRs.

  6. Biochemical and Phylogenetic Characterization of a Novel Diaminopimelate Biosynthesis Pathway in Prokaryotes Identifies a Diverged Form of ll-Diaminopimelate Aminotransferase▿ †

    OpenAIRE

    Hudson, André O.; Gilvarg, Charles; Leustek, Thomas

    2008-01-01

    A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an ll-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of l-2,3,4,5-tetrahydrodipicolinate to ll-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with o...

  7. X-ray digital industrial radiography (DIR) for local liquid velocity (V(LL)) measurement in trickle bed reactors (TBRs): validation of the technique.

    Science.gov (United States)

    Mohd Salleh, Khairul Anuar; Rahman, Mohd Fitri Abdul; Lee, Hyoung Koo; Al Dahhan, Muthanna H

    2014-06-01

    Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (V(LL)) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the V(LL) within TBRs.

  8. Akıllı Telefon Seçiminin Belirleyicileri: Üniversite Öğrencileri Üzerine Bir Uygulama

    Directory of Open Access Journals (Sweden)

    Halim TATLI

    2015-09-01

    Full Text Available Bu çalışmada, üniversite öğrencilerinin akıllı telefon seçimi üzerinde etkili olan faktörlerin tespit edilmesi amaçlanmıştır. Bu kapsamda, Bingöl Üniversitesinde okuyan öğrencilere uygulanan bir anketten elde edilen veriler kullanılmıştır. Bu anket, Ekim-Kasım 2014 tarihlerinde 400 öğrenciye uygulanmıştır. Öğrencilerin akıllı telefon seçimi cevap değişkeni, yaşın logaritması, aylık gelirin logaritması ve öğrencilerin akıllı telefona ilişkin bakış açılarının puanın logaritması açıklayıcı değişken olarak alınmıştır. Analizlerde lojistik regresyon kullanılmıştır. Tahmin edilen lojistik regresyon analizi sonucunda; öğrencilerin akıllı telefona ilişkin bakış açılarının puanın logaritması ve aylık gelirin logaritması anlamlı bir şekilde akıllı telefonu seçme olasılığını artırdığı tespit edilmiştir. Yaşın logaritması ile öğrencilerin akıllı telefon seçimi arasında anlamlı bir ilişki bulunamamıştır. Araştırmanın sonuçları, aylık gelir ve öğrencilerin akıllı telefona ilişkin bakış açıları, akıllı telefon seçiminin önemli belirleyicileri olduğunu göstermiştir.

  9. Performance of 2000CA/LL and 2260XL liquid scintillation spectrometers for low-level tritium and carbon-14 analyses

    International Nuclear Information System (INIS)

    Rozanski, K.; Stichler, W.; Schwarz, P.

    1991-01-01

    The performance of two commercially available liquid scintillation spectrometers for low-level counting of 3 H and 14 C has been investigated. Two models of new technology Tri-Carb spectrometers from the Packard Instrument Company were tested: the 2000CA/LL and 2260XL. The measurements revealed a superior 3 H performance of the 2000CA/LL equipment owing to its substantially higher counting efficiency. Results for 14 C are less conclusive and depend on the configuration of the counting parameters selected. A comparison of three commercially available scintillation cocktails for tritium assay in water samples revealed a superior performance for PicoFluor LLT. (Author)

  10. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults

    DEFF Research Database (Denmark)

    Dixon, Brian M; Barker, Tyler; McKinnon, Toni

    2012-01-01

    ABSTRACT: BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Significant levels of the protein hCAP18/LL-37 are found in the blood and may protect against...... = 0.63). CONCLUSIONS: We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37....

  11. Protein Profile and Plasmid Content of Lactococcus lactis subsp. lactis LL52 and Lactococcus lactis subsp. cremoris LC79 Strains under Several Stress Conditions

    OpenAIRE

    LALE, Rahmi; TÜKEL, Çağla; AKÇELİK, Mustafa

    2014-01-01

    Differences in the protein and plasmid content of 2 Lactococcus lactis strains, L. lactis subsp. lactis LL52 and L. lactis subsp. cremoris LC79, under the stresses of high and low temperature, osmotic shock, and low pH were determined. We identified 3 new proteins with molecular masses of 16.0, 29.4, and 45.0 kDa as high temperature stress response specific in strain LL52. High temperature stress did not cause any changes in the protein content of strain LC79. Proteins that were specific for ...

  12. Rare Λb→Λ l+l- and Λb→Λ γ decays in the relativistic quark model

    Science.gov (United States)

    Faustov, R. N.; Galkin, V. O.

    2017-09-01

    Rare Λb→Λ l+l- and Λb→Λ γ decays are investigated in the relativistic quark model based on the quark-diquark picture of baryons. The decay form factors are calculated accounting for all relativistic effects, including relativistic transformations of baryon wave functions from rest to a moving reference frame and the contribution of the intermediate negative-energy states. The momentum-transfer-squared dependence of the form factors is explicitly determined in the whole accessible kinematical range. The calculated decay branching fractions, various forward-backward asymmetries for the rare decay Λb→Λ μ+μ-, are found to be consistent with recent detailed measurements by the LHCb Collaboration. Predictions for the Λb→Λ τ+τ- decay observables are given.

  13. Threshold resummation at N3LL accuracy and soft-virtual cross sections at N3LO

    International Nuclear Information System (INIS)

    Catani, Stefano; Cieri, Leandro; Florian, Daniel de; Ferrera, Giancarlo; Grazzini, Massimiliano

    2014-01-01

    We consider QCD radiative corrections to the production of colorless high-mass systems in hadron collisions. We show that the recent computation of the soft-virtual corrections to Higgs boson production at N 3 LO [1] together with the universality structure of soft-gluon emission can be exploited to extract the general expression of the hard-virtual coefficient that contributes to threshold resummation at N 3 LL accuracy. The hard-virtual coefficient is directly related to the process-dependent virtual amplitude through a universal (process-independent) factorization formula that we explicitly evaluate up to three-loop order. As an application, we present the explicit expression of the soft-virtual N 3 LO corrections for the production of an arbitrary colorless system. In the case of the Drell–Yan process, we confirm the recent result of Ref. [2

  14. Measurement of the ratio σ{tt}/σ{Z/γ{*}→ll} and precise extraction of the tt cross section.

    Science.gov (United States)

    Aaltonen, T; Adelman, J; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; d'Errico, M; Di Canto, A; di Giovanni, G P; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, T; Dube, S; Ebina, K; Elagin, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Hughes, R E; Hurwitz, M; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leone, S; Lewis, J D; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Lovas, L; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramanov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Santi, L; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Simonenko, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Suh, J S; Sukhanov, A; Suslov, I; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wolfe, H; Wright, T; Wu, X; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhang, X; Zheng, Y; Zucchelli, S

    2010-07-02

    We report a measurement of the ratio of the tt to Z/γ{*} production cross sections in sqrt[s]=1.96  TeV pp collisions using data corresponding to an integrated luminosity of up to 4.6  fb{-1}, collected by the CDF II detector. The tt cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/γ{*}→ll cross section predicted by the standard model, the extracted tt cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result σ{tt}=7.70±0.52  pb, for a top-quark mass of 172.5  GeV/c{2}.

  15. Threshold resummation at N3LL accuracy and soft-virtual cross sections at N3LO

    Directory of Open Access Journals (Sweden)

    Stefano Catani

    2014-11-01

    Full Text Available We consider QCD radiative corrections to the production of colorless high-mass systems in hadron collisions. We show that the recent computation of the soft-virtual corrections to Higgs boson production at N3LO [1] together with the universality structure of soft-gluon emission can be exploited to extract the general expression of the hard-virtual coefficient that contributes to threshold resummation at N3LL accuracy. The hard-virtual coefficient is directly related to the process-dependent virtual amplitude through a universal (process-independent factorization formula that we explicitly evaluate up to three-loop order. As an application, we present the explicit expression of the soft-virtual N3LO corrections for the production of an arbitrary colorless system. In the case of the Drell–Yan process, we confirm the recent result of Ref. [2].

  16. The Stubenberg meteorite—An LL6 chondrite fragmental breccia recovered soon after precise prediction of the strewn field

    Science.gov (United States)

    Bischoff, Addi; Barrat, Jean-Alix; Bauer, Kerstin; Burkhardt, Christoph; Busemann, Henner; Ebert, Samuel; Gonsior, Michael; Hakenmüller, Janina; Haloda, Jakub; Harries, Dennis; Heinlein, Dieter; Hiesinger, Harald; Hochleitner, Rupert; Hoffmann, Viktor; Kaliwoda, Melanie; Laubenstein, Matthias; Maden, Colin; Meier, Matthias M. M.; Morlok, Andreas; Pack, Andreas; Ruf, Alexander; Schmitt-Kopplin, Philippe; SchöNbäChler, Maria; Steele, Robert C. J.; Spurný, Pavel; Wimmer, Karl

    2017-08-01

    On March 6, 2016 at 21:36:51 UT, extended areas of Upper Austria, Bavaria (Germany) and the southwestern part of the Czech Republic were illuminated by a very bright bolide. This bolide was recorded by instruments in the Czech part of the European Fireball Network and it enabled complex and precise description of this event including prediction of the impact area. So far six meteorites totaling 1473 g have been found in the predicted area. The first pieces were recovered on March 12, 2016 on a field close to the village of Stubenberg (Bavaria). Stubenberg is a weakly shocked (S3) fragmental breccia consisting of abundant highly recrystallized rock fragments embedded in a clastic matrix. The texture, the large grain size of plagioclase, and the homogeneous compositions of olivine (Fa31.4) and pyroxene (Fs25.4) clearly indicate that Stubenberg is an LL6 chondrite breccia. This is consistent with the data on O, Ti, and Cr isotopes. Stubenberg does not contain solar wind-implanted noble gases. Data on the bulk chemistry, IR spectroscopy, cosmogenic nuclides, and organic components also indicate similarities to other metamorphosed LL chondrites. Noble gas studies reveal that the meteorite has a cosmic ray exposure (CRE) age of 36 ± 3 Ma and that most of the cosmogenic gases were produced in a meteoroid with a radius of at least 35 cm. This is larger than the size of the meteoroid which entered the Earth's atmosphere, which is constrained to <20 cm from short-lived radionuclide data. In combination, this might suggest a complex exposure history for Stubenberg.

  17. Mutations in the Lactococcus lactis Ll.LtrB group II intron that retain mobility in vivo

    Directory of Open Access Journals (Sweden)

    D'Souza Lisa M

    2002-12-01

    Full Text Available Abstract Background Group II introns are mobile genetic elements that form conserved secondary and tertiary structures. In order to determine which of the conserved structural elements are required for mobility, a series of domain and sub-domain deletions were made in the Lactococcus lactis group II intron (Ll.LtrB and tested for mobility in a genetic assay. Point mutations in domains V and VI were also tested. Results The largest deletion that could be made without severely compromising mobility was 158 nucleotides in DIVb(1–2. This mutant had a mobility frequency comparable to the wild-type Ll.LtrB intron (ΔORF construct. Hence, all subsequent mutations were done in this mutant background. Deletion of DIIb reduced mobility to approximately 18% of wild-type, while another deletion in domain II (nts 404–459 was mobile to a minor extent. Only two deletions in DI and none in DIII were tolerated. Some mobility was also observed for a DIVa deletion mutant. Of the three point mutants at position G3 in DV, only G3A retained mobility. In DVI, deletion of the branch-point nucleotide abolished mobility, but the presence of any nucleotide at the branch-point position restored mobility to some extent. Conclusions The smallest intron capable of efficient retrohoming was 725 nucleotides, comprising the DIVb(1–2 and DII(iia,b deletions. The tertiary elements found to be nonessential for mobility were alpha, kappa and eta. In DV, only the G3A mutant was mobile. A branch-point residue is required for intron mobility.

  18. Effect of NaCrSi2O6 component on Lindsley's pyroxene thermometer: An evaluation based on strongly metamorphosed LL chondrites

    Science.gov (United States)

    Nakamuta, Y.; Urata, K.; Shibata, Y.; Kuwahara, Y.

    2017-03-01

    In Lindsley's thermometry, a revised sequence of calculation of components is proposed for clinopyroxene, in which kosmochlor component is added. Temperatures obtained for the components calculated by the revised method are about 50 °C lower than those obtained for the components calculated by the Lindsley's original method and agree well with temperatures obtained from orthopyroxenes. Ca-partitioning between clino- and orthopyroxenes is then thought to be equilibrated in types 5 to 7 ordinary chondrites. The temperatures for Tuxtuac (LL5), Dhurmsala (LL6), NWA 2092 (LL6/7), and Dho 011 (LL7) are 767-793°, 818-835°, 872-892°, and 917-936°C, respectively, suggesting that chondrites of higher petrographic types show higher equilibrium temperatures of pyroxenes. The regression equations which relate temperature and Wo and Fs contents in the temperature-contoured pyroxene quadrilateral of 1 atm of Lindsley (1983) are also determined by the least squares method. It is possible to reproduce temperatures with an error less than 20 °C (2SE) using the regression equations.

  19. Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL.

    Science.gov (United States)

    Cui, Yunxi; Koirala, Deepak; Kang, HyunJin; Dhakal, Soma; Yangyuoru, Philip; Hurley, Laurence H; Mao, Hanbin

    2014-05-01

    Minute difference in free energy change of unfolding among structures in an oligonucleotide sequence can lead to a complex population equilibrium, which is rather challenging for ensemble techniques to decipher. Herein, we introduce a new method, molecular population dynamics (MPD), to describe the intricate equilibrium among non-B deoxyribonucleic acid (DNA) structures. Using mechanical unfolding in laser tweezers, we identified six DNA species in a cytosine (C)-rich bcl-2 promoter sequence. Population patterns of these species with and without a small molecule (IMC-76 or IMC-48) or the transcription factor hnRNP LL are compared to reveal the MPD of different species. With a pattern recognition algorithm, we found that IMC-48 and hnRNP LL share 80% similarity in stabilizing i-motifs with 60 s incubation. In contrast, IMC-76 demonstrates an opposite behavior, preferring flexible DNA hairpins. With 120-180 s incubation, IMC-48 and hnRNP LL destabilize i-motifs, which has been previously proposed to activate bcl-2 transcriptions. These results provide strong support, from the population equilibrium perspective, that small molecules and hnRNP LL can modulate bcl-2 transcription through interaction with i-motifs. The excellent agreement with biochemical results firmly validates the MPD analyses, which, we expect, can be widely applicable to investigate complex equilibrium of biomacromolecules. © 2014 The Author(s). Published by Oxford University Press [on behalf of Nucleic Acids Research].

  20. Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice

    Directory of Open Access Journals (Sweden)

    Janmey Paul A

    2009-09-01

    Full Text Available Abstract Background The worldwide appearance of drug-resistant strains of H. pylori motivates a search for new agents with therapeutic potential against this family of bacteria that colonizes the stomach, and is associated with adenocarcinoma development. This study was designed to assess in vitro the anti-H. pylori potential of cathelicidin LL-37 peptide, which is naturally present in gastric juice, its optimized synthetic analog WLBU2, and the non-peptide antibacterial agent ceragenin CSA-13. Results In agreement with previous studies, increased expression of hCAP-18/LL-37 was observed in gastric mucosa obtained from H. pylori infected subjects. MBC (minimum bactericidal concentration values determined in nutrient-containing media range from 100-800 μg/ml for LL-37, 17.8-142 μg/ml for WLBU2 and 0.275-8.9 μg/ml for ceragenin CSA-13. These data indicate substantial, but widely differing antibacterial activities against clinical isolates of H. pylori. After incubation in simulated gastric juice (low pH with presence of pepsin CSA-13, but not LL-37 or WLBU2, retained antibacterial activity. Compared to LL-37 and WLBU2 peptides, CSA-13 activity was also more resistant to inhibition by isolated host gastric mucins. Conclusion These data indicate that cholic acid-based antimicrobial agents such as CSA-13 resist proteolytic degradation and inhibition by mucin and have potential for treatment of H. pylori infections, including those caused by the clarithromycin and/or metronidazole-resistant strains.

  1. The L-L oligomerization domain resides at the very N-terminus of the sendai virus L RNA polymerase protein

    International Nuclear Information System (INIS)

    Cevik, Bayram; Smallwood, Sherin; Moyer, Sue A.

    2003-01-01

    The Sendai virus RNA-dependent RNA polymerase is composed of the L and P proteins. We previously showed that the L protein gives intragenic complementation and forms an oligomer where the L-L interaction site mapped to the N-terminal half of the protein (S. Smallwood et al., 2002, Virology, 00, 000-000). We now show that L oligomerization does not depend on P protein and progressively smaller N-terminal fragments of L from amino acids (aa) 1-1146 through aa 1-174 all bind wild-type L. C-terminal truncations up to aa 424, which bind L, can complement the transcription defect in an L mutant altered at aa 379, although these L truncation mutants do not bind P. The fragment of L comprising aa 1-895, furthermore, acts as a dominant-negative mutant to inhibit transcription of wild-type L. N-terminal deletions of aa 1-189 and aa 1-734 have lost the ability to form the L-L complex as well as the L-P complex, although they still bind C protein. These data are consistent with the L-L interaction site residing in aa 1-174. Site-directed mutations in the N-terminal 347 aa, of L which abolish P binding, do not affect L-L complex formation, so while the L and P binding sites on L are overlapping they are mediated by different amino acids. The N-terminal portions of L with aa 1-424, aa 1-381, and to a lesser extent aa 1-174, can complement the transcription defect in an L mutant altered at aa 77-81, showing their L-L interaction is functional

  2. Experiences of a gully survey in the Gödöllő Hillside Landscape Protection District, Hungary

    Science.gov (United States)

    Szabó, Boglárka; Bolf, Balázs; Szabó, Judit; Centeri, Csaba

    2016-04-01

    In the 1970s when Highway No. 3. was built in Hungary, environmental issues were not thoroughly considered. The main scope of our survey is the analyses of a gully created by the runoff from the highway and from the upper watershed. These excess waters were channeled into natural valleys alongside the highway. Five outlets were created where the runoff water developed deep gullies and deposited huge amount of sediment at the tail of the gullies. The surveyed gully can be found in central Hungary, at the border of Gödöllő city, which area belongs to the Gödöllő Hillside Landscape Protection District. The experimental area is situated 175-220 meters above the sea level and it is crossed by the M3 motorway which took part in the development of the surveyed linear erosion form. During our survey, several dams and channel modifications, buffer ditches were built from materials found mainly locally, in order to decrease the energy of waters, to hold up the runoff and this way to eliminate the erosion damage in this protected area. However it is difficult to install and to maintain the protective measures. Due to the nature protection status the possible use of the materials and methods are limited. We surveyed the longest gully, which is 320 meters long and its width is exceeding 3 meters at its head, close to the motorway. The average depth is 1 meter. In order to monitor the amount of the runoff we planted some rods, where the height aboveground was known. The survey was made with GPS (Global Position System- Trimble Juno SB ArcPad 8.0) where along the gully the GPS recorded the position in every 20 seconds. Besides we recorded every dams and every sudden changes, where the direction, slope angle, depth, width or other characteristic was different. The data processing and the maps was made in ArcMap10.2, QGIS 2.2 and in Google Earth. Furthermore, micro soil profiles were taken from the riverbed to know the thickness of the runoff after bigger rainfall events. The

  3. Deletion of genes involved in glutamate metabolism to improve poly-gamma-glutamic acid production in B. amyloliquefaciens LL3.

    Science.gov (United States)

    Zhang, Wei; He, Yulian; Gao, Weixia; Feng, Jun; Cao, Mingfeng; Yang, Chao; Song, Cunjiang; Wang, Shufang

    2015-02-01

    Here, we attempted to elevate poly-gamma-glutamic acid (γ-PGA) production by modifying genes involved in glutamate metabolism in Bacillus amyloliquefaciens LL3. Products of rocR, rocG and gudB facilitate the conversion from glutamate to 2-oxoglutarate in Bacillus subtillis. The gene odhA is responsible for the synthesis of a component of the 2-oxoglutarate dehydrogenase complex that catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl coenzyme A. In-frame deletions of these four genes were performed. In shake flask experiments the gudB/rocG double mutant presented enhanced production of γ-PGA, a 38 % increase compared with wild type. When fermented in a 5-L fermenter with pH control, the γ-PGA yield of the rocR mutant was increased to 5.83 g/L from 4.55 g/L for shake flask experiments. The gudB/rocG double mutant produced 5.68 g/L γ-PGA compared with that of 4.03 g/L for the wild type, a 40 % increase. Those results indicated the possibility of improving γ-PGA production by modifying glutamate metabolism, and identified potential genetic targets to improve γ-PGA production.

  4. A case of exemplarity: C. F. Rottböll's history of smallpox inoculation in Denmark-Norway, 1766.

    Science.gov (United States)

    Eriksen, Anne

    2010-01-01

    Smallpox inoculation was one of the great discoveries of the 18th century and has been written into the grand narrative of medical progress, describing the taming of epidemic disease. Setting the perspective of progress aside, the article explores how this medical innovation was situated in 18th-century society and culture. The aim is to investigate how medical practice was intertwined with social structure and cultural patterns. The article takes its case from a book published in Copenhagen in 1766 by Professor C. F. Rottböll, former Head Physician of the Royal Inoculation House in Copenhagen. Being the first medical treatise on inoculation in Denmark-Norway, the book also has a historical section followed by a collection of reports and letters written by a number of other authors from various parts of the kingdom. Through close reading, the article explores how the introduction of the new technique was described in the texts. The reports were written to present practice and discuss cases. In doing so, they also presented a variety of other concerns so that a diversity of aims and intentions are added to the medical ones. The social and rhetorical strategies employed illuminate social ambition and systems of patronage, as well as understandings of history and of truth.

  5. Raspberry Pi Kullanılarak bir Akıllı Ev Uygulaması Geliştirilmesi

    OpenAIRE

    YÜZGEÇ, Uğur; ABA, Ömer

    2018-01-01

    Bu çalışmada Raspberry Pi mikrodenetleyici tabanlı bir akıllı ev uygulaması gerçekleştirilmiştir. Çalışmakapsamında 64 Bit BCM2837 Chip, 1.2 GHz ARM Cortex A53 dört çekirdekli işlemci özelliklerine sahip RaspberryPi 3 mikrodenetleyici ile ultrasonik, hareket algılayıcı, sıcaklık/nem, titreşim modülü, servo motoru, buzzer (sesmodülü), kamera, ateş algılayıcı, DC motor, LDR, RGB led, tuş takımı, su tespit, RFID kit sensörleri kullanılmıştır.Uygulama kısmında çeşitli senaryo durumları için yapıl...

  6. Seismically-triggered organic-rich layers in recent sediments from Göllüköy Lake (North Anatolian Fault, Turkey)

    KAUST Repository

    Avsar, Ulas

    2014-09-29

    Multi-proxy analyses on the sedimentary sequence of Göllüköy Lake, which is located on the eastern North Anatolian Fault (NAF), reveals a complete and high-resolution paleoseismic record for the last 650 years. Six sedimentary events are detected in a 3.1 m-long piston core. They form distinct organic-rich intercalations within the background sedimentation, which are characterized by strong anomalies on the loss-on-ignition (LOI550) and total organic carbon (TOC) profiles, as well as by lighter colours on the X-ray radiographic images. Itrax micro-XRF core scanner data are also used to contribute to the detection and characterization of the event deposits. After the detection of the sedimentary events, their temporal correlation with the earthquakes in the historical seismicity catalogue of the NAF is tested. The youngest event is dated to 1940s by using 210Pb and 137Cs profiles in sediment, which coincides with the 1939 earthquake (Ms = 7.7) on the NAF. The ages of the older five events are determined based on radiocarbon dating and regional time–stratigraphic correlation. Radiocarbon dating on the bulk sediment samples does not provide reliable results due to hard-water effect. On the other hand, dating on charcoals, Ephippia of Daphnia and phragmite remains significantly improves the results and implies a mean sedimentation rate of 0.28 cm/yr. Based on this preliminary sedimentation rate, we show that organic matter content variations through our record correlate with the varve-based δ18O record of Nar Lake, which is located 350 km southwest of Göllüköy Lake. Accordingly, high-precipitation/low-evaporation climatic episodes detected in Nar Lake are represented by higher organic matter content in Göllüköy sediments. Fine-tuning the Göllüköy LOI550 record to the Nar δ18O record reveals that the ages of the sedimentary events in Göllüköy match with well-known historical earthquakes that occurred around the lake. Finally, the origin of the organic

  7. Seismically-triggered organic-rich layers in recent sediments from Göllüköy Lake (North Anatolian Fault, Turkey)

    KAUST Repository

    Avsar, Ulas; Hubert-Ferrari, Auré lia; De Batist, Marc; Lepoint, Gilles; Schmidt, Sabine; Fagel, Nathalie

    2014-01-01

    Multi-proxy analyses on the sedimentary sequence of Göllüköy Lake, which is located on the eastern North Anatolian Fault (NAF), reveals a complete and high-resolution paleoseismic record for the last 650 years. Six sedimentary events are detected in a 3.1 m-long piston core. They form distinct organic-rich intercalations within the background sedimentation, which are characterized by strong anomalies on the loss-on-ignition (LOI550) and total organic carbon (TOC) profiles, as well as by lighter colours on the X-ray radiographic images. Itrax micro-XRF core scanner data are also used to contribute to the detection and characterization of the event deposits. After the detection of the sedimentary events, their temporal correlation with the earthquakes in the historical seismicity catalogue of the NAF is tested. The youngest event is dated to 1940s by using 210Pb and 137Cs profiles in sediment, which coincides with the 1939 earthquake (Ms = 7.7) on the NAF. The ages of the older five events are determined based on radiocarbon dating and regional time–stratigraphic correlation. Radiocarbon dating on the bulk sediment samples does not provide reliable results due to hard-water effect. On the other hand, dating on charcoals, Ephippia of Daphnia and phragmite remains significantly improves the results and implies a mean sedimentation rate of 0.28 cm/yr. Based on this preliminary sedimentation rate, we show that organic matter content variations through our record correlate with the varve-based δ18O record of Nar Lake, which is located 350 km southwest of Göllüköy Lake. Accordingly, high-precipitation/low-evaporation climatic episodes detected in Nar Lake are represented by higher organic matter content in Göllüköy sediments. Fine-tuning the Göllüköy LOI550 record to the Nar δ18O record reveals that the ages of the sedimentary events in Göllüköy match with well-known historical earthquakes that occurred around the lake. Finally, the origin of the organic

  8. CERN Library | Cecilia Jarlskog presents "Portrait of Gunnar Källén: a physics shooting star and poet of early quantum field theory" | 16 September

    CERN Multimedia

    2014-01-01

    Wolfgang Pauli referred to him as 'my discovery', Robert Oppenheimer described him as 'one of the most gifted theorists' and Niels Bohr found him enormously stimulating. Who was the man in question, Gunnar Källén (1926-1968)?   His appearance in the physics sky was like a shooting star. His contributions to the scientific debate caused excitement among young and old. Similar to his friend and mentor, Wolfgang Pauli, he demanded honesty and rigour in physics - a distinct dividing line between fact and speculation. In his obituary, Arthur S. Wightman would write: "Gunnar Källén was a proud continuer of the tradition in quantum field theory established by Wolfgang Pauli. His papers on quantum electrodynamics in the period 1950-1954 carried the non-perturbative approach to quantum electrodynamics forward to a point beyond which very little essential progress has been made up to the present day. At the time I was trying ...

  9. Angular dependence of Ll, L $\\alpha$ , L $\\beta$ and L $\\gamma$ X-ray differential and fluorescence cross-sections for Er, Ta, W, Au, Hg and Tl

    CERN Document Server

    Demir, L; Kurucu, Y; Karabulut, A; Sahin, Y; 10.1016/S0969-806X(02)00501-7

    2003-01-01

    Ll, L alpha , L beta and L gamma X-ray differential cross-sections, fluorescence cross-sections and L/sub i/-subshell ( sigma /sub L1/, sigma /sub L2/, and sigma /sub L3/) fluorescence cross-sections were measured for Er, Ta, W, Au, Hg, and Tl at an excitation energy of 59.6 keV using a Si(Li) detector. The differential cross-sections for these elements have been measured at different angles varying from 54 degrees to 153 degrees at intervals of 9 degrees . The Ll and L alpha groups in the L X-ray lines are found to be spatially anisotropic, while those in the L beta and L gamma peaks are isotropic. Experimental and theoretical values of L X-ray fluorescence cross- sections and L/sub i/-subshell X-ray fluorescence cross-sections were compared. (20 refs).

  10. Signs and the design of life - Uexküll's significance today : a symposium, its significant history and future / Torsten Rüting

    Index Scriptorium Estoniae

    Rüting, Torsten

    2004-01-01

    2004. aastal tähistati mitut Jakob von Uexkülli tähtpäeva - 140. sünniaastapäeva, 60. surmaaastapäeva ja 70 aasta möödumist tema kuulsa teose "Jalutuskäik läbi loomade ja inimeste omailma" avaldamisest. Selle tähistamiseks korraldati Hamburgis sümpoosion "Signs and design of life - Uexküll`s significance today" (9.1.2004.a.)

  11. Efficacy of the Direct Instruction Language for Learning (DI-LL) Program to Promote Expressive and Receptive Language in Children with Autism Spectrum Disorder

    Science.gov (United States)

    2016-07-01

    Evaluator on PLP & CGI 1-3 Train staff on DOSL 1-3 Purchase child materials ( toys , stickers) 1-3 Purchase testing materials 1-3 Purchase DI-LL...been developed to address language delay including intensive treatment using applied behavior analysis (ABA). Although often effective for severe...to severe. Many interventions have been developed to address language delay including intensive treatment using applied behavior analysis (ABA

  12. Genetic mapping of the LOBED LEAF 1 (ClLL1) gene to a 127.6-kb region in watermelon (Citrullus lanatus L.).

    Science.gov (United States)

    Wei, Chunhua; Chen, Xiner; Wang, Zhongyuan; Liu, Qiyan; Li, Hao; Zhang, Yong; Ma, Jianxiang; Yang, Jianqiang; Zhang, Xian

    2017-01-01

    The lobed leaf character is a unique morphologic trait in crops, featuring many potential advantages for agricultural productivity. Although the majority of watermelon varieties feature lobed leaves, the genetic factors responsible for lobed leaf formation remain elusive. The F2:3 leaf shape segregating population offers the opportunity to study the underlying mechanism of lobed leaf formation in watermelon. Genetic analysis revealed that a single dominant allele (designated ClLL1) controlled the lobed leaf trait. A large-sized F3:4 population derived from F2:3 individuals was used to map ClLL1. A total of 5,966 reliable SNPs and indels were identified genome-wide via a combination of BSA and RNA-seq. Using the validated SNP and indel markers, the location of ClLL1 was narrowed down to a 127.6-kb region between markers W08314 and W07061, containing 23 putative ORFs. Expression analysis via qRT-PCR revealed differential expression patterns (fold-changes above 2-fold or below 0.5-fold) of three ORFs (ORF3, ORF11, and ORF18) between lobed and non-lobed leaf plants. Based on gene annotation and expression analysis, ORF18 (encoding an uncharacterized protein) and ORF22 (encoding a homeobox-leucine zipper-like protein) were considered as most likely candidate genes. Furthermore, sequence analysis revealed no polymorphisms in cDNA sequences of ORF18; however, two notable deletions were identified in ORF22. This study is the first report to map a leaf shape gene in watermelon and will facilitate cloning and functional characterization of ClLL1 in future studies.

  13. Kablosuz Duyarga Ağları ile Engelli İnsanlar İçin Akıllı Ev Uygulamaları

    OpenAIRE

    Işılak, Ali Haktan; Baydere, Şebnem

    2011-01-01

    Akıllı evler geleceğin tasarım kavramları arasında olmaktan çıkmıştır. Günümüzde, içinde yaşayanların yaşam tarzlarını doğrudan etkileyen evler tasarlanmaktadır. Akıllı ev sistemlerinin amacı, tanımlanmış aktivitelerin farkında olan bir ortam yaratmaktır. Engelli insanlar günlük hayatlarını kolaylaştırmak için bu sistemlere ihtiyaç duymaktadırlar. Bu çalışmada engelli insanların hayatlarını kolaylaştırmak amacıyla farklı engel türleri için duyarga ağları ile bazı akıllı ev uygulamaları gelişt...

  14. Biochemical and phylogenetic characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes identifies a diverged form of LL-diaminopimelate aminotransferase.

    Science.gov (United States)

    Hudson, André O; Gilvarg, Charles; Leustek, Thomas

    2008-05-01

    A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an LL-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of L-2,3,4,5-tetrahydrodipicolinate to LL-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with other dap genes, suggestive of a polycistronic structure. The DapL candidate enzymes were found to cluster into two classes sharing approximately 30% amino acid identity. The function of selected enzymes from each class was studied. Both classes were able to functionally complement Escherichia coli dapD and dapE mutants and to catalyze LL-DAP transamination, providing functional evidence for a role in DAP/lysine biosynthesis. In all cases the occurrence of dapL in a species correlated with the absence of genes for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase. The results indicate that the DapL pathway is restricted to specific lineages of eubacteria including the Cyanobacteria, Desulfuromonadales, Firmicutes, Bacteroidetes, Chlamydiae, Spirochaeta, and Chloroflexi and two archaeal groups, the Methanobacteriaceae and Archaeoglobaceae.

  15. M4FT-16LL080303052-State of Knowledge for Colloid Facilitated Radionuclide Transport and Update on Actinide Diffusion in Bentonite Backfill

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Inst.. Physical and Life Sciences; Joseph, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Inst.. Physical and Life Sciences

    2016-08-16

    This progress report (Level 4 Milestone Number M4FT-16LL080303052) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Crystalline Disposal R&D Activity Number FT-16LL080303051 and Crystalline International Collaborations Activity Number FT-16LL080303061. The focus of this research is the interaction of radionuclides with Engineered Barrier System (EBS) and host rock materials at various physico-chemical conditions relevant to subsurface repository environments. They include both chemical and physical processes such as solubility, sorption, and diffusion. The colloid-facilitated transport effort focused on preparation of a draft manuscript summarizing the state of knowledge and parameterization of colloid-facilitated transport mechanisms in support of reactive transport and performance assessment models for generic crystalline repositories. This draft manuscript is being submitted as a level 3 milestone with LANL as the primary author. LLNL’s contribution to that effort is summarized only briefly in the present report. A manuscript summarizing long-term U(VI) diffusion experiments through bentonite backfill material was recently accepted for publication; the contents of that manuscript are summarized in the present report. The Np(IV) diffusion experiments were started mid-year and are ongoing. The completion of these experiments is planned for early FY17. Our progress in quantifying Np(IV) diffusion in bentonite backfill is summarized in the present report. Our involvement with the NEA TDB project was summarized in a recent Argillite Disposal activity report. It is not included in this report.

  16. Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice.

    Science.gov (United States)

    Kim, Miri; Kim, Jongsic; Jeong, Seo-Won; Jo, Hyunmu; Park, Hyun Jeong

    2018-02-01

    Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser (LPND) effectively treats rosacea, although the underlying mechanism is unclear, to evaluate the histological effects and molecular mechanism of LPND on LL-37-induced rosacea-like skin lesions in mice. Intradermal injection of LL-37 was performed into the dorsal skin of BALB/c mice (n = 30) twice a day for 2 days. Fifteen mice were treated with LPND. After 48 h, the excised skin sample was stained for histology and type I collagen; transforming growth factor (TGF)-β, matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinase (TIMP)-1, tumor necrosis factor (TNF)-α, and interleukin (IL)-1α mRNA levels were determined by real-time RT-PCR. Intradermal injection of LL-37 induced rosacea-like clinical features. LPND treatment significantly reduced erythema and increased dermal collagen production. Levels of Type I collagen, TGF-β, and MMP-1 mRNA were significantly higher in LPND-treated mice than in untreated mice. LPND may improve rosacea by ameliorating dermal connective tissue disorganization and elastosis through MMP-mediated dermal collagen remodeling.

  17. The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania.

    Science.gov (United States)

    Tinoco-Nunes, Bruno; Telleria, Erich Loza; da Silva-Neves, Monique; Marques, Christiane; Azevedo-Brito, Daisy Aline; Pitaluga, André Nóbrega; Traub-Csekö, Yara Maria

    2016-04-20

    Lutzomyia longipalpis is the main vector of visceral leishmaniasis in Latin America. Sandfly immune responses are poorly understood. In previous work we showed that these vector insects respond to bacterial infections by modulating a defensin gene expression and activate the Imd pathway in response to Leishmania infection. Aspects of innate immune pathways in insects (including mosquito vectors of human diseases) have been revealed by studying insect cell lines, and we have previously demonstrated antiviral responses in the L. longipalpis embryonic cell line LL5. The expression patterns of antimicrobial peptides (AMPs) and transcription factors were evaluated after silencing the repressors of the Toll pathway (cactus) and Imd pathway (caspar). AMPs and transcription factor expression patterns were also evaluated after challenge with heat-killed bacteria, heat-killed yeast, or live Leishmania. These studies showed that LL5 cells have active Toll and Imd pathways, since they displayed an increased expression of AMP genes following silencing of the repressors cactus and caspar, respectively. These pathways were also activated by challenges with bacteria, yeast and Leishmania infantum chagasi. We demonstrated that L. longipalpis LL5 embryonic cells respond to immune stimuli and are therefore a good model to study the immunological pathways of this important vector of leishmaniasis.

  18. Cosmogenic radionuclides and mineralogical properties of the Chelyabinsk (LL5) meteorite: What do we learn about the meteoroid?

    Science.gov (United States)

    Povinec, Pavel P.; Laubenstein, Matthias; Jull, A. J. Timothy; FerrièRe, Ludovic; BrandstäTter, Franz; Sýkora, Ivan; Masarik, Jozef; BeåO, Juraj; KováčIk, Andrej; Topa, Dan; Koeberl, Christian

    2015-02-01

    On February 15, 2013, after the observation of a brilliant fireball and a spectacular airburst over the southern Ural region (Russia), thousands of stones fell and were rapidly recovered, bringing some extremely fresh material for scientific investigations. We undertook a multidisciplinary study of a dozen stones of the Chelyabinsk meteorite, including petrographic and microprobe investigations to unravel intrinsic characteristics of this meteorite. We also study the short and long-lived cosmogenic radionuclides to characterize the initial meteoroid size and exposure age. Petrographic observations, as well as the mineral compositions obtained by electron microprobe analyses, allow us to confirm the classification of the Chelyabinsk meteorite as an LL5 chondrite. The fragments studied, a few of which are impact melt rocks, contain abundant shock melt veins and melt pockets. It is likely that the catastrophic explosion and fragmentation of the Chelyabinsk meteoroid into thousands of stones was in part determined by the initial state of the meteoroid. The radionuclide results obtained show a wide range of concentrations of 14C, 22Na, 26Al, 54Mn, 57Co, 58Co, and 60Co, which indicate that the pre-atmospheric object had a radius >5 m, consistent with other size estimates based on the magnitude of the airburst caused by the atmospheric entry and breakup of the Chelyabinsk meteoroid. Considering the observed 26Al activities of the investigated samples, Monte Carlo simulations, and taking into account the 26Al half-life (0.717 Myr), the cosmic-ray exposure age of the Chelyabinsk meteorite is estimated to be 1.2 ± 0.2 Myr. In contrast to the other radionuclides, 14C showed a very large range only consistent with most samples having been exposed to anthropogenic sources of 14C, which we associate with radioactive contamination of the Chelyabinsk region by past nuclear accidents and waste disposal, which has also been confirmed by elevated levels of anthropogenic 137Cs and

  19. Technology-enhanced language learning (TeLL: An update and a principled framework for English for Academic Purposes (EAP courses / L'apprentissage des langues assisté par la technologie (TeLL: mise à jour et énoncé de principes pour les cours

    Directory of Open Access Journals (Sweden)

    Juliana Chau

    2014-05-01

    Full Text Available The range and number of technologies currently available have yielded both opportunities and challenges for language educators. This study aims to review recent technology-enhanced language learning (TeLL research, and to examine their potential relevance to EAP pedagogy, curricula, assessment and instruction. The results of this study show TeLL research with rising interest in vocabulary, grammar and writing, but less so in speaking, listening, and reading. The results also reveal a shift from a tool-centric view of technology use to one that emphasises the technology-pedagogy-human alliance in the last decade, noting three emerging trends in recent TeLL studies, namely, those that are multi-purpose, multi-genre, and multi-role/skill in design and evaluation. The lack of a holistic approach to TeLL for EAP courses to date, however, has made it necessary and desirable to develop a framework for EAP-specific TeLL, to identify a principle for a generic TeLL programme, and to propound ways of operationalizing such a framework. L'apprentissage des langues assisté par la technologie (TeLL: mise à jour et énoncé de principes pour les cours d’anglais à des fins universitaires La variété et la profusion de technologies actuellement disponibles ont engendré des possibilités nouvelles et des défis pour les enseignants en langue. Cette étude passe en revue la recherche récente consacrée à l'apprentissage des langues assisté par la technologie (TeLL et examine sa pertinence éventuelle pour la pédagogie, les programmes, l'évaluation et l'enseignement de l’anglais à des fins universitaires. Les résultats de cette étude révèlent un intérêt croissant de la recherche sur l'apprentissage des langues assisté par la technologie pour le vocabulaire, la grammaire et l'écriture, mais un intérêt moindre pour la langue parlée, la langue écoutée et pour la lecture. Les résultats révèlent aussi que, dans la dernière décennie, on

  20. Lectins from Synadenium carinatum (ScLL) and Artocarpus heterophyllus (ArtinM) Are Able to Induce Beneficial Immunomodulatory Effects in a Murine Model for Treatment of Toxoplasma gondii Infection.

    Science.gov (United States)

    Ramos, Eliézer L P; Santana, Silas S; Silva, Murilo V; Santiago, Fernanda M; Mineo, Tiago W P; Mineo, José R

    2016-01-01

    Infection by Toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine, and folinic acid. However, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. Thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients with toxoplasmosis. It has been described that lectins from plants can control parasite infections, when used as immunological adjuvants in vaccination procedures. This type of lectins, such as ArtinM and ScLL is able to induce immunostimulatory activities, including efficient immune response against parasites. The present study aimed to evaluate the potential immunostimulatory effect of ScLL and ArtinM for treatment of T. gondii infection during acute phase, considering that there is no study in the literature accomplishing this issue. For this purpose, bone marrow-derived macrophages (BMDMs) were treated with different concentrations from each lectin to determine the maximum concentration without or with lowest cytotoxic effect. After, it was also measured the cytokine levels produced by these cells when stimulated by the selected concentrations of lectins. We found that ScLL showed high capacity to induce of pro-inflammatory cytokine production, while ArtinM was able to induce especially an anti-inflammatory cytokines production. Furthermore, both lectins were able to increase NO levels. Next, we evaluated the treatment effect of ScLL and ArtinM in C57BL/6 mice infected by ME49 strain from T. gondii . The animals were infected and treated with ScLL, ArtinM, ArtinM plus ScLL, or sulfadiazine, and the following parameters analyzed: Cytokines production, brain parasite burden and survival rates. Our results demonstrated that the ScLL or ScLL plus ArtinM treatment induced

  1. Lectins from Synadenium carinatum (ScLL and Artocarpus heterophyllus (ArtinM are able to induce beneficial immunomodulatory effects in a murine model for treatment of Toxoplasma gondii infection

    Directory of Open Access Journals (Sweden)

    Leandro Peixoto Ferreira Souza

    2016-11-01

    Full Text Available Infection by Toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine and folinic acid. However, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. Thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients with toxoplasmosis. It has been described that lectins from plants can control parasite infections, when used as immunological adjuvants in vaccination procedures. This type of lectins, such as ArtinM and ScLL is able to induce immunostimulatory activities, including efficient immune response against parasites. The present study aimed to evaluate the potential immunostimulatory effect of ScLL and ArtinM for treatment of T. gondii infection during acute phase, considering that there is no study in the literature accomplishing this issue. For this purpose, bone marrow-derived macrophages (BMDMs were treated with different concentrations from each lectin to determine the maximum concentration without or with lowest cytotoxic effect. After, it was also measured the cytokine levels produced by these cells when stimulated by the selected concentrations of lectins. We found that ScLL showed high capacity to induce of pro-inflammatory cytokine production, while ArtinM was able to induce especially an anti-inflammatory cytokines production. Furthermore, both lectins were able to increase NO levels. Next, we evaluated the treatment effect of ScLL and ArtinM in C57BL/6 mice infected by ME49 strain from T. gondii. The animals were infected and treated with ScLL, ArtinM, ArtinM plus ScLL or sulfadiazine, and the following parameters analyzed: cytokines production, brain parasite burden and survival rates. Our results demonstrated that the ScLL or ScLL plus Artin

  2. Measurement of the W ¿ l¿ and Z/¿* ¿ ll production cross sections in proton-proton collisions at vs= 7 TeV with the ATLAS detector

    DEFF Research Database (Denmark)

    Aad...[], G.; Dam, Mogens; Hansen, John Renner

    2010-01-01

    First measurements of the W ¿ l¿ and Z/¿ * ¿ ll (l = e, µ) production cross sections in proton-proton collisions at s=7TeV are presented using data recorded by the ATLAS experiment at the LHC. The results are based on 2250 W ¿ l¿ and 179 Z/¿ * ¿ ll candidate events selected from a data set corres...

  3. Measurement of K/sub NN/, K/sub LL/ in p vector d → n vector X and p vector 9Be → n vector X at 800 MeV

    International Nuclear Information System (INIS)

    Riley, P.J.; Hollas, C.L.; Newsom, C.R.

    1980-01-01

    The spin transfer parameters, K/sub NN/ and K/sub LL/, have been measured in p vector d → n vector X and p vector 9 Be → n vector X at 0 0 and 800 MeV. The rather large values of K/sub LL/ demonstrate that this transfer mechanism will provide a useful source of polarized neutrons at LAMPF energies

  4. Measurement of K/sub NN/, K/sub SS/, K/sub SL/, and K/sub LL/ in polarized np → polarized pn at 800 MeV in the CEX region

    International Nuclear Information System (INIS)

    Ransome, R.D.; Hollas, C.L.; Riley, P.J.

    1980-01-01

    The spin transfer parameters K/sub NN/, K/sub SS/, K/sub SL/, and K/sub LL/ have been measured for np elastic scattering at 800 MeV between 165 0 and 180 0 c.m. The parameters K/sub NN/ and K/sub LL/ are in good agreement with the quasi-free reaction polarized pd → polarized npp at 180 0

  5. Esterase polymorphism in remanant populations of Aspidosperma polyneuron Müll.Arg. (Apocynaceae Polimorfismo de esterases em populações remanescentes de Aspidosperma polyneuron Müll.Arg. (Apocynaceae

    Directory of Open Access Journals (Sweden)

    Vanda Marilza de Carvalho

    2004-10-01

    Full Text Available The population genetic structure of the endangered tree species Aspidosperma polyneuron Mull.Arg. (Apocynaceae was reported based on analysis of esterase polymorphism in two remanant populations. Allelic variation was detected at three isoesterase loci (Est-3, Est-9, and Est-10. The proportion of polymorphic loci for both populations was 30% and deviation from Hardy-Weinberg equilibrium was observed for the Est-3 locus observed in the northern population. Segregation distortion and the lower level of observed and expected heterozygosity in this population were attributed to founder genotype. The high genetic identity values for northern and northwestern populations are in accordance with the low levels of interpopulation genetic divergence demonstrated by the F(ST (0.03 value. The F(IS value (0.23 indicated moderate levels of inbreeding. A. polyneuron can be indicated as an example of endangered species suggesting high genetic variation in contrast to the low genetic variation reported for endangered species. The esterase isozymes may be a good genetic marker for studies of natural A. polyneuron populations.A análise do polimorfismo de isozimas esterases foi usada para reportar a estrutura genética de duas populações remanecentes da espécie de árvore em extinção Aspidosperma polyneuron Müll.Arg. (Apocynaceae. Variação alélica foi detectada em três locos de isoesterases (Est-3, Est-9, e Est-10. A proporção de locos polimórficos de ambas as populações foi de 30%, sendo observado um desvio do equilíbrio de Hardy-Weinberg no loco Est-3 na população da região norte do Estado do Paraná. Uma distorção na segregação e um mais baixo nível de heterozigosidade observada e esperada nesta população foram atribuídos ao efeito do genótipo fundador. Os valores altos de identidade genética das populações do norte e noroeste do Estado estão de acordo com o baixo nível de divergência genética interpopulacional demonstrado

  6. Biochemical and Phylogenetic Characterization of a Novel Diaminopimelate Biosynthesis Pathway in Prokaryotes Identifies a Diverged Form of ll-Diaminopimelate Aminotransferase▿ †

    Science.gov (United States)

    Hudson, André O.; Gilvarg, Charles; Leustek, Thomas

    2008-01-01

    A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an ll-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of l-2,3,4,5-tetrahydrodipicolinate to ll-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with other dap genes, suggestive of a polycistronic structure. The DapL candidate enzymes were found to cluster into two classes sharing approximately 30% amino acid identity. The function of selected enzymes from each class was studied. Both classes were able to functionally complement Escherichia coli dapD and dapE mutants and to catalyze ll-DAP transamination, providing functional evidence for a role in DAP/lysine biosynthesis. In all cases the occurrence of dapL in a species correlated with the absence of genes for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase. The results indicate that the DapL pathway is restricted to specific lineages of eubacteria including the Cyanobacteria, Desulfuromonadales, Firmicutes, Bacteroidetes, Chlamydiae, Spirochaeta, and Chloroflexi and two archaeal groups, the Methanobacteriaceae and Archaeoglobaceae. PMID:18310350

  7. 1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model.

    Science.gov (United States)

    Gonzalez-Curiel, Irma; Trujillo, Valentin; Montoya-Rosales, Alejandra; Rincon, Kublai; Rivas-Calderon, Bruno; deHaro-Acosta, Jeny; Marin-Luevano, Paulina; Lozano-Lopez, Daniel; Enciso-Moreno, Jose A; Rivas-Santiago, Bruno

    2014-01-01

    Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing. It has been recently reported that patients with DFU have lower levels of antimicrobial peptides (AMPs) at the lesion area, which contributes with the impairment of wound healing. The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3) and L-isoleucine induced HBD-2 and LL-37 in primary cultures from DFU. We developed primary cell cultures from skin biopsies from 15 patients with DFU and 15 from healthy donors. Cultures were treated with 1,25 (OH)2D3 or L-isoleucine for 18 h. Keratinocytes phenotype was identified by western blot and flow cytometry. Real time qPCR for DEFB4, CAMP and VDR gene expression was performed as well as an ELISA to measure HBD-2 and LL-37 in supernatant. Antimicrobial activity, in vitro, wound healing and proliferation assays were performed with conditioned supernatant. The results show that primary culture from DFU treated with 1,25(OH)2D3, increased DEFB4 and CAMP gene expression and increased the production of HBD-2 and LL-37 in the culture supernatant. These supernatants had antimicrobial activity over E. coli and induced remarkable keratinocyte migration. In conclusion the 1,25(OH)2D3 restored the production of AMPs in primary cell from DFU which were capable to improve the in vitro wound healing assays, suggesting their potential therapeutic use on the treatment of DFU.

  8. 1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model.

    Directory of Open Access Journals (Sweden)

    Irma Gonzalez-Curiel

    Full Text Available Diabetic foot ulcers (DFU are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing. It has been recently reported that patients with DFU have lower levels of antimicrobial peptides (AMPs at the lesion area, which contributes with the impairment of wound healing. The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 (1,25 (OH2 D3 and L-isoleucine induced HBD-2 and LL-37 in primary cultures from DFU. We developed primary cell cultures from skin biopsies from 15 patients with DFU and 15 from healthy donors. Cultures were treated with 1,25 (OH2D3 or L-isoleucine for 18 h. Keratinocytes phenotype was identified by western blot and flow cytometry. Real time qPCR for DEFB4, CAMP and VDR gene expression was performed as well as an ELISA to measure HBD-2 and LL-37 in supernatant. Antimicrobial activity, in vitro, wound healing and proliferation assays were performed with conditioned supernatant. The results show that primary culture from DFU treated with 1,25(OH2D3, increased DEFB4 and CAMP gene expression and increased the production of HBD-2 and LL-37 in the culture supernatant. These supernatants had antimicrobial activity over E. coli and induced remarkable keratinocyte migration. In conclusion the 1,25(OH2D3 restored the production of AMPs in primary cell from DFU which were capable to improve the in vitro wound healing assays, suggesting their potential therapeutic use on the treatment of DFU.

  9. The study of rare B{sub c}→D{sub s,d}{sup (∗)}ll-macron decays

    Energy Technology Data Exchange (ETDEWEB)

    Ju, Wan-Li; Wang, Guo-Li [Department of Physics, Harbin Institute of Technology,Harbin, 150001 (China); Fu, Hui-Feng [Department of Physics, Tsinghua University,Beijing, 100084 (China); Wang, Tian-Hong; Jiang, Yue [Department of Physics, Harbin Institute of Technology,Harbin, 150001 (China)

    2014-04-09

    In this paper, we study rare decays B{sub c}→D{sub s,d}{sup (∗)}ll-macron within the Standard Model. The penguin, box, annihilation, color-favored cascade and color-suppressed cascade contributions are included. Based on our calculation, the annihilation and color-favored cascade diagrams play important roles in the differential branching fractions, forward-backward asymmetries, longitudinal polarizations of the final vector mesons and leptonic longitudinal polarization asymmetries. More importantly, color-favored cascade decays largely enhance the resonance cascade contributions. To avoid the resonance cascade contribution pollution, new cutting regions are put forward.

  10. Seletividade do Clomazone no Manejo Químico de Plantas Daninhas da Cultura do Algodão LL(r)

    OpenAIRE

    Arantes, J.G.Z.; Constantin, J.; Oliveira Jr., R.S.; Braz, G.B.P.; Takano, H.K.; Gemelli, A.; Oliveira Neto, A.M.; Brugnera, P.

    2015-01-01

    O amonio-glufosinate é um herbicida de amplo espectro de controle de plantas daninhas, porém não apresenta controle residual no solo, o que limita sua utilidade quando usado isoladamente na cultura do algodão, havendo a necessidade de combinar diferentes herbicidas em mais de uma modalidade de aplicação. O objetivo deste trabalho foi avaliar a seletividade de diferentes sistemas de controle químico de plantas daninhas contendo clomazone na cultura do algodão LL(r). As misturas triplas em pré-...

  11. Angular analysis of B→K"*ll and search for B"+→K"+ττ at the BELLE experiment

    International Nuclear Information System (INIS)

    Wehle, Simon

    2016-09-01

    Rare decays of B mesons are an ideal probe to search for phenomena beyond the Standard Model of particle physics, since contributions from new particles can affect the decays on the same level as Standard Model predictions. The rare decay of B→K"("*")l"+l"- offers the quark transition b→sl"+l"-, a flavor changing neutral current which is forbidden at tree level in the Standard Model. Higher order processes such as penguin or W"+W"- box diagrams allow for these processes, leading to branching ratios of less than one in a million. Various extensions to the Standard Model predict influences of new physics, which can enhance or suppress branching ratios or lead to changes in angular distributions of the decay products. In order to produce a sufficient amount of B mesons, the so-called B-factories were designed. One of them is the asymmetric-energy e"+e"- collider KEKB with the Belle experiment, located in Tsukuba, Japan. During 1999 to 2010 the experiment recorded a total luminosity of 1 ab"-"1 of electron positron collisions. In this thesis a comprehensive study of the flavor changing neutral current process b→sl"+l"- in B meson decays with accompanying kaons is presented in two separate analyses. All three lepton modes, e"+e"-, μ"+μ"- and τ"+τ"- are investigated to search for evidence of physics beyond the Standard Model. The measurements are performed using the full Belle data sample of 772 x 10"6 B anti B pairs, recorded at the Υ(4S) resonance energy. The first analysis in this thesis covers the muon and electron modes in the decay of B"0→K"*(892)"0l"+l"-. To maximize signal efficiency and purity, neural networks are developed sequentially from the bottom to the top of the decay chain, transferring each time the output probability to the subsequent step such that most effective selection cuts are applied in the last stage based on all information combined. Reconstructed signal yields of both channels exceed previous B-factory results of Belle and Ba

  12. Threshold resummation at N{sup 3}LL accuracy and soft-virtual cross sections at N{sup 3}LO

    Energy Technology Data Exchange (ETDEWEB)

    Catani, Stefano [INFN, Sezione di Firenze and Dipartimento di Fisica e Astronomia, Università di Firenze, I-50019 Sesto Fiorentino, Florence (Italy); Cieri, Leandro [Dipartimento di Fisica, Università di Roma “La Sapienza” and INFN, Sezione di Roma, I-00185 Rome (Italy); Florian, Daniel de [Departamento de Física, FCEYN, Universidad de Buenos Aires, (1428) Pabellón 1 Ciudad Universitaria, Capital Federal (Argentina); Ferrera, Giancarlo [Dipartimento di Fisica, Università di Milano and INFN, Sezione di Milano, I-20133 Milan (Italy); Grazzini, Massimiliano [Physik-Institut, Universität Zürich, CH-8057 Zürich (Switzerland)

    2014-11-15

    We consider QCD radiative corrections to the production of colorless high-mass systems in hadron collisions. We show that the recent computation of the soft-virtual corrections to Higgs boson production at N{sup 3}LO [1] together with the universality structure of soft-gluon emission can be exploited to extract the general expression of the hard-virtual coefficient that contributes to threshold resummation at N{sup 3}LL accuracy. The hard-virtual coefficient is directly related to the process-dependent virtual amplitude through a universal (process-independent) factorization formula that we explicitly evaluate up to three-loop order. As an application, we present the explicit expression of the soft-virtual N{sup 3}LO corrections for the production of an arbitrary colorless system. In the case of the Drell–Yan process, we confirm the recent result of Ref. [2].

  13. Mössbauer parameters of ordinary chondrites influenced by the fit accuracy of the troilite component: an example of Chelyabinsk LL5 meteorite

    Energy Technology Data Exchange (ETDEWEB)

    Maksimova, A. A. [Ural Federal University, Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology (Russian Federation); Klencsár, Z. [Hungarian Academy of Sciences, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences (Hungary); Oshtrakh, M. I., E-mail: oshtrakh@gmail.com; Petrova, E. V.; Grokhovsky, V. I. [Ural Federal University, Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology (Russian Federation); Kuzmann, E.; Homonnay, Z. [Eötvös Loránd University, Institute of Chemistry (Hungary); Semionkin, V. A. [Ural Federal University, Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology (Russian Federation)

    2016-12-15

    The influence of the fit accuracy of the troilite component in the Mössbauer spectra of ordinary chondrites on the parameters obtained for other spectral components was evaluated using the Mössbauer spectrum of Chelyabinsk LL5 meteorite fragment with light lithology as a typical example. It was shown that with respect to the application of a usual sextet component where quadrupole interaction is taken into account in the first-order perturbation limit, substantial improvement of the spectrum fit can be achieved either by using the full Hamiltonian description of the troilite component or by its formal approximation with the superposition of three symmetric doublet components. Parameter values obtained for the main spectral components related to olivine and pyroxene were not sensitive to the fit of troilite component while parameters of the minor spectral components depended on the way of troilite component fitting.

  14. Genetical structure of populations of modelling species of terrestrial mollusks in conditions of the urbanized landscape on example Сhondrula tridens Müll (Gastropoda, Pulmonata

    Directory of Open Access Journals (Sweden)

    Eduard A Snegin

    2011-06-01

    Full Text Available On the basis of the analysis of the morphological and genetical variability revealed by a method of gel-electrophoresis of proteins in PAAG, the state of gene pools of populations of modeling species Сhondrula tridens Müll (threedens snail in conditions of the urbanized forest-steppe landscape of the south of Mid-Russia Upland is investigated. In the majority of the investigated bunches authentic decrease of a level of heterozygosity and the decrease of an allelic diversification caused, both is fixed by natural historical factors, and factors of an anthropogenic parentage. The genetic-automatic processes in populations are considered and vectors of natural selection are defined. Calculation of effective number of researched bunches is spent.

  15. Complete characterization of the spasing (L-L) curve of a three-level quantum coherence enhanced spaser for design optimization

    Science.gov (United States)

    Kumarapperuma, Lakshitha; Premaratne, Malin; Jha, Pankaj K.; Stockman, Mark I.; Agrawal, Govind P.

    2018-05-01

    We demonstrate that it is possible to derive an approximate analytical expression to characterize the spasing (L-L) curve of a coherently enhanced spaser with 3-level gain-medium chromophores. The utility of this solution stems from the fact that it enables optimization of the large parameter space associated with spaser designing, a functionality not offered by the methods currently available in the literature. This is vital for the advancement of spaser technology towards the level of device realization. Owing to the compact nature of the analytical expressions, our solution also facilitates the grouping and identification of key processes responsible for the spasing action, whilst providing significant physical insights. Furthermore, we show that our expression generates results within 0.1% error compared to numerically obtained results for pumping rates higher than the spasing threshold, thereby drastically reducing the computational cost associated with spaser designing.

  16. Cycles of time in the Iberian culture: the astronomical orientation of the temple of El Tossal de Sant Miquel de Llíria

    Directory of Open Access Journals (Sweden)

    Esteban, César

    2006-06-01

    Full Text Available We present an archaeoastronomical study of the temple of the Iberian settlement of El Tossal de Sant Miquel de Llíria (València. We find that the major axis of the building is oriented very close to the east-west cardinal axis. The entrance of the temple is pointing towards an outstanding mountain on the eastern horizon, where the sunrise around the equinoxes takes place. On the other hand, the absence of other constructions just in front of the cultic building seems to support the inference that the astronomical relation was intentional, because it would permit the observation of the sunrise from the temple. The existence of other nearby Iberian sanctuaries showing similar relations with the equinoxes (or a date very close to them strongly supports the importance of these solar dates in the Iberian ritual.

    Presentamos un estudio arqueoastronómico del templo del poblado ibérico del Tossal de Sant Miquel de Llíria (Valencia. Encontramos que el eje mayor del edificio se encuentra orientado casi paralelo al eje cardinal este-oeste, con su entrada apuntando hacia una montaña singular del horizonte oriental donde se produce el orto solar alrededor de los equinoccios. Por otra parte, la ausencia de construcciones justo enfrente de la entrada del templo parece apoyar la intencionalidad de dicha relación astronómica, pues permitiría preservar la observación del fenómeno desde el edificio. La existencia de otros yacimientos ibéricos cercanos donde se han encontrado relaciones similares con los equinoccios (o una fecha muy cercana a éstos apunta, cada vez más claramente, hacia la idea de un especial protagonismo del paso del sol por los equinoccios en el calendario ritual ibérico.

  17. Design of a virtual tour for the enhancement of Llíria’s architectural and urban heritage and its surroundings

    Directory of Open Access Journals (Sweden)

    José Miguel Maícas

    2017-07-01

    Full Text Available The Information Technology and Communications (ICT have revolutionized the way to present and promote the heritage sites. These ICT also offer scholars, students and visitors unprecedented access to architectural, historical, geographical, archaeological, iconographical and anthropological data, among other. It is noted also that virtual heritage environments are inherently fascinating and possess essential properties to have a positive effect on supporting heritage conservation and education. This paper is concerned with the potential of these ICT developments for improving the enhancement of the heritage sites of the town of Llíria and its surroundings (Valencia, Spain by mean of a virtual tour (“Edeta 360º” based on 360º panorama photos. The “Edeta 360º” virtual tour is an immersive application that places the viewers inside the image, enabling them to significantly enhance position awareness and providing the highest level of functionality for viewing, capturing and analysing virtual data. It can appropriately and effectively be utilised to facilitate intellectual and physical access to public by bringing knowledge, awareness and appreciation about the heritage of Llíria while, at the same time, authenticity is preserved. The undertaking method to create this interactive virtual tour is based on an easy procedure with off-the-shelf equipment and using both freely available software to address the process of photo stitching that combines multiple photographic images with overlapping fields of view to produce a segmented panorama or high-resolution image. Each panorama contains hotspots that enable the users to further explore the surroundings. The virtual tour provides the user the ability to navigate a scene through the rotation and zoom functions. This application results very appealing and has been adopted as a mean for information, dissemination, education and tourism purposes.

  18. IL-33 mast cell axis is central in LL-37 induced bladder inflammation and pain in a murine interstitial cystitis model.

    Science.gov (United States)

    Martin Jensen, M; Jia, Wanjian; Schults, Austin J; Ye, Xiangyang; Prestwich, Glenn D; Oottamasathien, Siam

    2018-05-18

    Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is a debilitating chronic condition that afflicts over 3 million women above the age of 18 in the U.S., and most patients fail to respond to current treatment options. Mast cells have previously been implicated as both a diagnostic and prognostic marker in IC/PBS. Patients with IC/PBS have been shown to have elevated levels of IL-33, a cytokine released in response to tissue insult, in their urine. We hypothesize that mast cell-mediated inflammation induced from IL-33 may play an important role in initiating pain and inflammation in IC/PBS. A human cathelicidin, LL-37, which is found at elevated levels in IC/PBS patients, was used to induce an IC/PBS-like state of inflammation and bladder pain in mast cell deficient C-kit (-/-) and wild type C57Bl/6 (WT) mice. Inflammation was quantified using myeloperoxidase (MPO) expression in bladder tissues measured via ELISA. Response rate to suprapubic stimulation from von Frey filaments was used to assess the relative pain and discomfort. Both types of mice increased IL-33 expression in response to LL-37 exposure. However, mast cell deficient mice demonstrated significantly lower levels of inflammation (p < 0.001) and reduced pain response (p < 0.001) compared to WT mice. These findings implicate an IL-33-mast cell dependent axis with a potential etiology of pain and inflammation in IC/PBS. Future therapeutics aimed at targeting the IL-33 - mast cell axis could potentially serve as useful targets for treating IC/PBS. Copyright © 2018. Published by Elsevier Ltd.

  19. Correction: Forrester, N.L.; Coffey, L.L.; Weaver, S.C. Arboviral Bottlenecks and Challenges to Maintaining Diversity and Fitness during Mosquito Transmission. Viruses 2014, 6, 3991–4004

    Directory of Open Access Journals (Sweden)

    Naomi L. Forrester

    2014-11-01

    Full Text Available In the original manuscript, Forrester, N.L.; Coffey, L.L.; Weaver, S.C. Arboviral Bottlenecks and Challenges to Maintaining Diversity and Fitness during Mosquito Transmission. Viruses 2014, 6, 3991–4004, Figure 1 contains an error, the third bottle was absent from the figure:[...

  20. Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells

    International Nuclear Information System (INIS)

    Sugisawa, Nobusuke; Matsuoka, Masato; Okuno, Takeo; Igisu, Hideki

    2004-01-01

    When NIH3T3 cells were exposed to CdCl 2 , the three major mitogen-activated protein kinases (MAPKs), extracellular signal-regulated protein kinase (ERK), c-Jun NH 2 -terminal kinase (JNK), and p38, were phosphorylated in a time (1-9 h)- and dose (1-20 μM)-dependent manner. Treatment with a macrocyclic nonaketide compound, LL-Z1640-2 (10-100 ng/ml), suppressed the phosphorylation of MAPKs without affecting the total protein level in cells exposed to 10 μM CdCl 2 for 6 h. CdCl 2 -induced phosphorylation of c-Jun on Ser63 and that on Ser73, and resultant accumulation of total c-Jun protein were also suppressed by LL-Z1640-2 treatment. The in vitro kinase assays also showed significant inhibitory effects of LL-Z1640-2 (at 10 or 25 ng/ml) on JNK and p38 but less markedly. In contrast to JNK and p38, ERK activity was inhibited moderately only at 50 or 100 ng/ml LL-Z1640-2. On the other hand, other JNK inhibitors, SP600125 and L-JNKI1, failed to suppress CdCl 2 -induced activation of the JNK pathway. Among the mouse stress response genes upregulated in response to CdCl 2 exposure, the expressions of hsp68 (encoding for heat shock 70 kDa protein 1; Hsp70-1) and grp78 (encoding for 78 kDa glucose-regulated protein; Grp78) genes were suppressed by treatment with 25 ng/ml LL-Z1640-2. Thus, LL-Z1640-2 could suppress CdCl 2 -induced activation of JNK/p38 pathways and expression of HSP70 family genes in NIH3T3 cells. LL-Z1640-2 seems to be useful to analyze functions of toxic metal-induced JNK/p38 activation

  1. Efecto del extracto metanólico de Jatropha macrantha Müll. Arg., en la disfunción eréctil inducida en ratas

    Directory of Open Access Journals (Sweden)

    Aldo Tinco

    2011-07-01

    Full Text Available Objetivos: Determinar el efecto del extracto metanólico de Jatropha macrantha Müll. Arg. ‘huanarpo macho’ en la disfunción eréctil inducida en ratas. Diseño: Experimental. Institución: Laboratorio de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú; Laboratorio de Farmacia, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, Perú. Material biológico: Extracto metanólico de Jatropha macrantha Müll Arg. ‘huanarpo macho’; ratas wistar de 300+/-50 g. Intervenciones: La obtención de la muestra se realizó en la Provincia de Vilcas Huamán - Ayacucho. Se evaluó el comportamiento sexual y la concentración de óxido nítrico y el efecto vasorrelajante en el cuerpo cavernoso aislado de pene de ratas, siendo los grupos de estudio: grupo 1 agua 10 mL/kg; grupo 2 sildenafilo 5 mg/kg; grupos 3, 4 y 5 extracto metanólico 100, 200 y 300 mg/kg. Se aisló órganos en los grupos de 50, 100 y 300 ug/mL de extracto, L- arginina 300 uM, acetilcolina 30uM, epinefrina u/mL y sildenafilo (3,2 × 10-5 mg/mL. Principales medidas de resultados: Flavonoides aislados, comportamiento sexual de ratas, niveles plasmáticos de óxido nítrico y relajación del músculo cavernoso. Resultados: Por cromatografía se encontró estructuras tipo flavonas, y mediante espectroscopia UV y reacciones de desplazamiento se identificó 6-hidroxi-4’,5,7-trimetoxi flavona, 4’,7-dihidroxi-5,6-dimetoxiflavona, 7-hidroxi-3’,4’,5’,5,8 pentametoxiflavona, 4’,7-dihidroxi-3’,5,6-trimetoxiflavona, DL50 1357 mg/kg. El comportamiento sexual fue dosis dependiente; la administración de 300 mg/kg de la planta por vía oral incrementó la frecuencia de monta en 75% y elevó los niveles de óxido nítrico en 85%, en tanto que la dosis de 200 mg/kg lo hizo en 71,1% y 32,4%, respectivamente (p<0,05. Conclusiones: En ratas con disfunción eréctil inducida, el extracto metanólico de Jatropha macrantha Müll Arg.

  2. THE EFFECT OF DIFFERENT OPTIONS OF BLADES MAIN ROTOR ON THE X-SHAPED TAIL ROTOR OF THE MI-171 LL

    Directory of Open Access Journals (Sweden)

    Valery A. Ivchin

    2018-01-01

    Full Text Available This paper describes the effect of different rotor blades on the X-shaped tail rotor of the Mi-171 LL, observed conducting flight tests. The tests were carried out on the same helicopter in the similar atmospheric conditions.The objective of the tests was the comparison of flight performance of two sets of rotor blades of the helicopter Mi-171 LL. However, materials test revealed a difference in the angles of the tail rotor at different MRs with the same takeoff weight.The authors are grateful to I.G. Peskov, S.R. Zamula and A.I. Orlov for assistance in carrying out this work and the preparation of this article.Noted that the helicopter takeoff weight when hovering out of ground effect in ISA with blades from polymer composite materials (PCM exceeds the takeoff weight of the helicopter with the serial blades in the nominal mode of the engine operation at ~ 750kg, in the takeoff mode at ~ 700kg.Knowing the altitude and climatic characteristics of the engine, the obtained dependence allows to determine the balancing value of jрв on hovering at different combinations of pressure altitude and outside air temperature for a given speed of the main rotor (MR.It follows from the work that when the same value Nпр(95/nнвпр3 or Nfact the balancing values of jрв for the helicopter with the main rotor blades from the PCM is less than for the helicopters with serial blades by 0.5…0.9°. The difference in the angles of the tail rotor increases with growing of Nепр(95/nнвпр3 (Nfact. Perhaps this is caused by different induction effect of the main rotor on the tail rotor to the MR from PCM and the serial ones.As follows from the materials, the thrust of the main rotor with blades from PCM with the same engine power is more in comparison with the serial blades. Consequently inductive speeds of the main rotor are more and the angles of the tail rotor are less. It can be assumed that a large induced velocity of the main rotor increases the thrust

  3. Grupos de edad y género en un nuevo vaso del Tossal de Sant Miquel de Llíria (Valéncia

    Directory of Open Access Journals (Sweden)

    Isabel Izquierdo Peraile

    2005-01-01

    Full Text Available Presentamos en este trabajo una tinaja de grandes dimensiones inédita con decoración figurada procedente de la ciudad ibérica del Tossal de Sant Miquel de Llíria (Valencia. Con un elevado índice de fragmentación. el vaso muestra interesantes figuraciones como una escena femenina de hilado y tejido, joven a caballo, así como damas estantes. Su iconografía nos aproxima al análisis de los grupos de edad y género en la cultura ibérica: ternas como la naturaleza o los rituales de tránsito a la edad adulta. La dimensión simbólica de las escenas plasmadas en este vaso de encargo se integra en el programa de imágenes de la antigua Edeta, en un marco urbano y aristocrático, de tradición mediterránea.

  4. Comparison of Nickel XANES Spectra and Elemental Maps from a Ureilite, a LL3.8 Ordinary Chondrite, Two Carbonaceous Chondrites and Two Large Cluster IDPs

    Science.gov (United States)

    Wirick, S.; Flynn, G. J.; Sutton, S.; Zolensky, M. E.

    2014-01-01

    Nickel in the extraterrestrial world is commonly found in both Fe-Ni sulfide and Fe-Ni met-al forms [1] and in the pure metal state in the interior of iron meteorites where it is not easily oxidized. Ni is also found in olivine, pyroxene and glasses and in some melts the partitioning of Ni between the olivines and glass is controlled by the amount of S in the melt [2]. Its most common valence state is Ni(2+) but Ni also occurs as Ni(0), Ni(+), and Ni(3+) and rarely as Ni(2-), Ni(1-) and Ni(4+) [3]. It's valence state in olivines is Ni(2+) in octa-hedral coordination on the M1 site and rarely on the M2 site.[4]. The chemical sensitivity of X-ray absorp-tion near-edge structure (XANES) spectroscopy is well established and can be used to determine not only va-lence states but also coordination sites [5]. We report here Ni XANES spectroscopy and elemental maps collected from 2 carbonaceous chondrites, 2 large clus-ter IDPs, 1 ureilite and 1 LL3 orginary chondrite.Using XANES it may be possible to find a common trait in the large cluster IDPs that will also be found in mete-orite samples.

  5. Surveillance of environmental risks for the health in the area of the construction of hydroelectric project Porce ll, Antioquia Colombia 1997 -2000

    International Nuclear Information System (INIS)

    Gonzalez P, Claudia; Rios V Claudia; Osorio Q, Lisardo; Valencia Lia, Marta; Escobar V, Juan Pablo; Lopez A, Yolanda

    2002-01-01

    The effects on the health of the human populations generated by the construction of dams for the energy production, not always have been considered when the construction of the work is planned. Van Thiel (1962), Gartrell et al. (1972), Ackerman et al. (1973), Brown and Deom (1973), Waddy (1973, 1975), Stanley and Alpers (1975), Worthington (1978), Eguniwe (1976) y Paiva (1982). This study pilot in the country watched during four years the environmental conditions of risk for the health in the hydroelectric project Porce ll during its construction and the pertinent measures were recommended, to protect the conditions of health of the population worker and the inhabitants of the area of influence of this one. In periodic form, the work camping, work fronts and medical centers were inspected. The main problem observed through the time was related to the deficient processes of washing and disinfections in the sanitary services and restaurants and the presence of diverse vectors breeding place of diseases, appearing greater problem in the rims in disuse and carps that were used to cover the structures and equipment that was stored outdoors. Most of the factors of risk for the health they were corrected Colombia. Through the time and in so me it was necessary to insist on the given recommendations

  6. Many-electron effect in the Si K-LL resonant Auger-electron spectroscopy spectra of the Si delta layer in GaAs

    International Nuclear Information System (INIS)

    Ohno, Masahide

    2006-01-01

    The Si K-LL resonant Auger-electron spectroscopy (RAES) spectra of silicon delta dopped layers in GaAs with very thin capping layers show both normal Auger decay and resonant Auger decay, when the core-level electron is excited to the conduction band. The resonant Auger peak kinetic energy (KE) shows no dispersion with photon energy, except when excited by the highest energy photons [M.D. Jackson, J.M.C. Thornton, D. Lewis, A. Robinson, M. Fahy, A. Aviary, P. Weightman, Phys. Rev. B71 (2005) 075313]. The RAES spectra are analyzed using a many-body theory. The presence of resonant Auger decay and no dispersion of resonant Auger peak KE with photon energy is explained in terms of the relaxation of a metastable excited core-hole state to a stable one on the time scale of core-hole decay. The excited electron in the conduction band either delocalizes rapidly leaving the ionized Si to decay by a normal Auger decay or drops to a state localized in the Si delta layer before the core-hole decays so that the RAES spectrum has both normal Auger decay and resonant Auger decay. As a result of the relaxation, the resonant Auger peak KE does not show any dispersion with photon energy. The variations with photon energy of the normal or resonant Auger peak intensity, KE, and width are explained in a consistent manner by a many-body theory

  7. Adjustment and start-up of an irradiator self shielding model Isogamma LL.CO. in the Centre of Technological Applications and Nuclear Development

    International Nuclear Information System (INIS)

    Gonzalez, Dania Soguero; Ardanza, Armando Chavez

    2013-01-01

    This paper describes the process of installation of a self-shielded irradiator category I, model ISOGAMMA LL.Co of 60 Co, with a nominal 25 kCi activity, rate of absorbed dose 8 kG/h and 5 L workload. The stages are describe step by step: import, the customs procedure which included the interview with the master of the vessel transporter, the monitoring of the entire process by the head of radiological protection of the importing Center, control of the levels of surface contamination of the shipping container of the sources before the removal of the ship, the supervision of the national regulatory authority and the transportation to the final destination. Details of assembling of the installation and the opening of the container for transportation of supplies is outlined. The action plan previously developed for the case of occurrence of radiological successful events is presented, detailing the phase of the load of radioactive sources by the specialists of the company selling the facility (IZOTOP). Finally describes the setting and implementation of the installation and the procedure of licensing for exploitation

  8. LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity.

    Science.gov (United States)

    Kim, Eun Young; Rajasekaran, Ganesan; Shin, Song Yub

    2017-08-18

    KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We designed and synthesized a series of d-amino acid-substituted analogs of KR-12-a5 with the aim of developing novel α-helical AMPs that possess higher cell selectivity than KR-12-a5, while maintaining the anti-inflammatory activity. d-amino acid incorporation into KR-12-a5 induced a significant improvement in the cell selectivity by 2.6- to 13.6-fold as compared to KR-12-a5, while maintaining the anti-inflammatory activity. Among the three analogs, KR-12-a5 (6- D L) with d-amino acid in the polar-nonpolar interface (Leu 6 ) showed the highest cell selectivity (therapeutic index: 61.2). Similar to LL-37, KR-12-a5 and its analogs significantly inhibited the expression and secretion of NO, TNF-α, IL-6 and MCP-1 from LPS-stimulated RAW264.7 cells. KR-12-a5 and its analogs showed a more potent antimicrobial activity against antibiotic-resistant bacteria, including clinically isolated MRSA, MDRPA, and VREF than LL-37 and melittin. Furthermore, compared to LL-37, KR-12-a5 and its analogs showed greater synergistic effects with conventional antibiotics, such as chloramphenicol, ciprofloxacin, and oxacillin against MDRPA; KR-12-a5 and its analogs had a FICI range between 0.25 and 0.5, and LL-37 had a range between 0.75 and 1.5. KR-12-a5 and its analogs were found to be more effective anti-biofilm agents against MDRPA than LL-37. In addition, KR-12-a5 and its analogs maintained antimicrobial activity in physiological salts and human serum. SYTOX Green uptake and membrane depolarization studies revealed that KR-12-a5 and its analogs kills microbial cells by permeabilizing the cell membrane and damaging membrane integrity. Taken together, our results suggest that KR-12-a5 and its analogs can be developed further as novel antimicrobial/anti-inflammatory agents to treat antibiotic-resistant infections. Copyright

  9. In-office tooth bleaching with 38% hydrogen peroxide promotes moderate/severe pulp inflammation and production of ll-1β, TNF-β, GPX, FGF-2 and osteocalcin in rats.

    Science.gov (United States)

    Silva-Costa, Renata Suellen Galvão da; Ribeiro, Andressa Eveline de Lima; Assunção, Isauremi Vieira de; Araújo Júnior, Raimundo Fernandes de; Araújo, Aurigena Antunes de; Guerra, Gerlane Coelho Bernardo; Borges, Boniek Castillo Dutra

    2018-06-11

    To study the intensity of inflammatory infiltrate and production of interleukin-1β (ll-1β), tumor necrosis factor-β (TNF-β), fibroblast growth factor-2 (FGF-2), glutathione peroxidase (GPX), and osteocalcin in response to in-office tooth bleaching in rats. Twenty male Wistar rats were randomized into four groups (n=5) according to the received treatment (tooth bleaching or no treatment - control) and the period of euthanasia after treatment (24 h or 10 days). We performed tooth bleaching using a 38% hydrogen peroxide gel on maxillary and mandibular incisors. After euthanasia, incisors (20 per group) were processed for histological analysis, immunohistochemistry staining of ll-1β, TNF-β, FGF-2 and GPX and osteocalcin by immunofluorescence. We analyzed data using the Mann-Whitney and Kruskal-Wallis/Dunn tests (p<0.05). The bleached groups presented statistically significant differences regarding the pulp inflammation stage compared with the control groups. Bleached teeth showed moderate/severe inflammatory infiltrate and control groups presented absent inflammatory cells or a negligible number of mononuclear cells (p<0.001) at two times (24 h and 10 days). There was strong staining for ll-1β, TNF-β, and GPX in bleached groups at 24 h and strong staining for ll-1β, TNF-β, GPX and FGF-2 at 10 days. After 10 days of tooth bleaching, the bleached group showed a statistically superior amount of osteocalcin than the other groups (p<0.01). Tooth bleaching with 38% hydrogen peroxide causes severe pulp inflammation, but characteristics of tissue repair after 10 days.

  10. In-office tooth bleaching with 38% hydrogen peroxide promotes moderate/severe pulp inflammation and production of ll-1β, TNF-β, GPX, FGF-2 and osteocalcin in rats

    Directory of Open Access Journals (Sweden)

    Renata Suellen Galvão da Silva-Costa

    2018-06-01

    Full Text Available Abstract Objectives: To study the intensity of inflammatory infiltrate and production of interleukin-1β (ll-1β, tumor necrosis factor-β (TNF-β, fibroblast growth factor-2 (FGF-2, glutathione peroxidase (GPX, and osteocalcin in response to in-office tooth bleaching in rats. Material and Methods: Twenty male Wistar rats were randomized into four groups (n=5 according to the received treatment (tooth bleaching or no treatment - control and the period of euthanasia after treatment (24 h or 10 days. We performed tooth bleaching using a 38% hydrogen peroxide gel on maxillary and mandibular incisors. After euthanasia, incisors (20 per group were processed for histological analysis, immunohistochemistry staining of ll-1β, TNF-β, FGF-2 and GPX and osteocalcin by immunofluorescence. We analyzed data using the Mann-Whitney and Kruskal-Wallis/Dunn tests (p<0.05. Results: The bleached groups presented statistically significant differences regarding the pulp inflammation stage compared with the control groups. Bleached teeth showed moderate/severe inflammatory infiltrate and control groups presented absent inflammatory cells or a negligible number of mononuclear cells (p<0.001 at two times (24 h and 10 days. There was strong staining for ll-1β, TNF-β, and GPX in bleached groups at 24 h and strong staining for ll-1β, TNF-β, GPX and FGF-2 at 10 days. After 10 days of tooth bleaching, the bleached group showed a statistically superior amount of osteocalcin than the other groups (p<0.01. Conclusions: Tooth bleaching with 38% hydrogen peroxide causes severe pulp inflammation, but characteristics of tissue repair after 10 days.

  11. Higgs production in vector boson fusion in the H{yields} {tau}{tau} {yields} ll + 4{nu} final state with ATLAS. A sensitivity study

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Martin

    2011-05-15

    A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H{yields} {tau}{tau} {yields} ll + 4{nu} is presented. The study is based on simulated proton-proton collisions at a centre-of-mass energy of 14 TeV. For the rst time the discovery potential is evaluated in the presence of additional proton-proton interactions (pile-up) to the process of interest in a complete and consistent way. Special emphasis is placed on the development of background estimation techniques to extract the main background processes Z{yields} {tau}{tau} and t anti t production using data. The t anti t background is estimated using a control sample selected with the VBF analysis cuts and the inverted b-jet veto. The dominant background process Z {yields} {tau}{tau} is estimated using Z{yields} {mu}{mu} events. Replacing the muons of the Z{yields} {mu}{mu} event with simulated {tau}-leptons, Z {yields} {tau}{tau} events are modelled to high precision. For the replacement of the Z boson decay products a dedicated method based on tracks and calorimeter cells is developed. Without pile-up a discovery potential of 3{sigma} to 3.4{sigma} in the mass range 115 GeV

  12. The HILW-LL (high- and intermediate-level waste, long-lived) disposal project: working toward building the Cigeo Industrial Centre for Geological Disposal

    International Nuclear Information System (INIS)

    Labalette, Th.

    2011-01-01

    The French Act of 28 June 2006 identifies reversible disposal in deep geological facilities as the benchmark solution for long-term management of high-level waste (HLW) and for intermediate-level long-lived waste (ILW-LL). The Act tasks ANDRA (national agency for the management of radioactive wastes) with the pursuit of studies and research on the choice of a site and the design of the repository, with a view to examining the licence application in 2015 and, provided that the licence is granted, to make the facility operational by 2025. At the end of 2009, ANDRA submitted to the Government its proposals regarding the site and the design of the Industrial Centre for Geological Disposal, known as CIGEO. With the definition of a possible area for the construction of underground disposal facilities, one of the key stages in the project has been achieved. The choice of a surface site will be validated following the public consultation scheduled for the end of 2012. The project is now on the point of entering the definition stage (preliminary design). CIGEO will be a nuclear facility unlike any other. It will be built and operated for a period of over 100 years. For it to be successful, the project must meet certain requirements related to its integration in the local area, industrial planning, safety and reversibility, while also controlling costs. Reversibility is a very important concept that will be defined by law. It is ANDRA's responsibility to ensure that a reasonable balance is found between these different concerns. (author)

  13. Higgs production in vector boson fusion in the H→ ττ → ll + 4ν final state with ATLAS. A sensitivity study

    International Nuclear Information System (INIS)

    Schmitz, Martin

    2011-05-01

    A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H→ ττ → ll + 4ν is presented. The study is based on simulated proton-proton collisions at a centre-of-mass energy of 14 TeV. For the rst time the discovery potential is evaluated in the presence of additional proton-proton interactions (pile-up) to the process of interest in a complete and consistent way. Special emphasis is placed on the development of background estimation techniques to extract the main background processes Z→ ττ and t anti t production using data. The t anti t background is estimated using a control sample selected with the VBF analysis cuts and the inverted b-jet veto. The dominant background process Z → ττ is estimated using Z→ μμ events. Replacing the muons of the Z→ μμ event with simulated τ-leptons, Z → ττ events are modelled to high precision. For the replacement of the Z boson decay products a dedicated method based on tracks and calorimeter cells is developed. Without pile-up a discovery potential of 3σ to 3.4σ in the mass range 115 GeV H -1 . In the presence of pile-up the signal sensitivity decreases to 1.7σ to 1.9σ mainly caused by the worse resolution of the reconstructed missing transverse energy. (orig.)

  14. Gottlieb Bindesbøll

    DEFF Research Database (Denmark)

    Kristensen, Peter Thule

    This monograph provides the first presentation and analysis of the Danish architect Gottlieb Bindesbøll’s (1800-1856) oeuvre. It shows how, regardless of the style he chose, he created unity in a radically new way that brings to mind nature’s own way of “designing.” How he conceived new signs...... also explains how many of his projects were linked to a national-liberal agenda that coincided with the advent of democracy in the revolutionary year of 1848. The publication is the story of a life’s work and societal developments seen and explained through architecture. With completely new photographs...

  15. Measurement of the pp → πd spin correlation parameters A/sub SL/ and A/sub LL/ at energies between 500 and 800 MeV

    International Nuclear Information System (INIS)

    Barlow, D.B.

    1984-11-01

    Angular distributions of the spin correlation parameters A/sub SL/ and A/sub LL/ for the inelastic reaction pp→πd have been measured at pion center-of-mass angles between 40 and 130 0 , at energies of 500, 650, and 800 MeV. Additional measurements of A/sub LL/(THETA) were made at 600, 700, and 750 MeV. The reaction was studied using an incident beam of either longitudinally polarized protons. Both the final state pion and deuteron were detected in a two-armed detector system. The momenta of particles detected in the deuteron arm were analyzed with a magnetic spectrometer which allowed the deuterons to be distinguished from particles produced by quasi-free, three-body, or other background reactions. A/sub SL/ was found to be negative (approx. = -0.5) at 500 MeV. It became increasingly more negative as energy increased, going down to as low as -0.88 at forward angles at 800 MeV. A/sub SL/ showed only a slight angular dependence in the entire energy range. The angular distribution of A/sub LL/ was found to be almost flat at 500 (approx. = -0.5) and 600 MeV (approx. = -0.4). As energy increased A/sub LL/ became less negative and began to peak at theta/sub cm/ = 90 0 . At 800 MeV A/sub LL/ was positive at almost all measured angles and had a well defined peak at theta/sub cm/ = 90 0 which reached a maximum of about +0.4. The data were compared to several partial wave analyses and to theoretical calculations based on unified theories of NN→NN, πd→πd, and NN→πd reactions. In general these later calculations were found to be unsuccessful in fitting our data. Partial wave analyses, which included the present data, fitted the data reasonably well and did not indicate the need for any unusual (dibaryon like) structures in any of the partial waves. 52 references

  16. Himatanthus lancifolius (Müll. Arg. Woodson, Apocynaceae: estudo farmacobotânico de uma planta medicinal da Farmacopeia brasileira 1ª edição Himatanthus lancifolius (Müll. Arg. Woodson, Apocynaceae: morpho-anatomical study of a medicinal plant described in the Brazilian Pharmacopoeia 1st edition

    Directory of Open Access Journals (Sweden)

    Leopoldo C. Baratto

    2010-11-01

    Full Text Available Himatanthus lancifolius (Müll. Arg. Woodson é um arbusto nativo do Brasil, latescente, popularmente conhecido como agoniada e utilizado principalmente para distúrbios menstruais. O presente trabalho teve como objetivo caracterizar morfoanatomicamente a folha, o caule e a casca caulinar dessa planta medicinal, a fim de contribuir para o controle de qualidade e a autenticidade dessa espécie. O material vegetal foi fixado e submetido às microtécnicas usuais. A folha é simples, glabra e obovado-lanceolada. A epiderme é uniestratificada, revestida por cutícula estriada e possui estômatos anisocíticos na face abaxial. O mesofilo é dorsiventral. A nervura central é biconvexa e o pecíolo é circular, ambos apresentando feixes vasculares bicolaterais. Laticíferos, amiloplastos e idioblastos fenólicos estão presentes no parênquima fundamental da nervura central e do pecíolo. O sistema vascular do caule é tipicamente bicolateral. Laticíferos e idioblastos fenólicos ocorrem no córtex, no floema e na medula. Esses caracteres morfoanatômicos, em conjunto, podem ser utilizados como parâmetros para o controle de qualidade dessa espécie.Himatanthus lancifolius (Müll. Arg. Woodson is a Brazilian native shrub, laticiferous, popularly known as "agoniada" and it is mainly used for uterine disorders. The present work aimed to study the leaf, stem and stem bark morpho-anatomy of this medicinal plant, in order to contribute to its quality control and identification. The plant material was fixed and submitted to standard microtechniques. The leaf is simple, glabrous and obovate-lanceolate. The epidermis is uniseriate, coated with striated cuticle and it has anysocitic stomata on the abaxial surface. The mesophyll is dorsiventral. The midrib is biconvex and the petiole is circular, both presenting bicollateral vascular bundles. Laticiferous ducts, amyloplasts and phenolic idioblasts are found in ground parenchyma of the midrib and petiole. The

  17. Applications of volatile compounds acquired from Muscodor heveae against white root rot disease in rubber trees (Hevea brasiliensis Müll. Arg.) and relevant allelopathy effects.

    Science.gov (United States)

    Siri-Udom, Sakuntala; Suwannarach, Nakarin; Lumyong, Saisamorn

    The bioactive compounds of the volatile metabolite-producing endophytic fungus, Muscodor heveae, were examined by the process of biofumigation for the purposes of controlling white root rot disease in rubber trees (Hevea brasiliensis Müll. Arg.). Volatile organic compounds (VOCs) of M. heveae possess antimicrobial activity against Rigidoporus microporus in vitro with 100 % growth inhibition. The synthetic volatile compounds test confirmed that the major component, 3-methylbutan-1-ol, and the minor compounds, 3-methylbutyl acetate and 2-methylpropanoic acid, inhibited root and shoot growth in the tested plants 3-methylbutan-1-ol showed ED 50 value and MIQ value on seed germination of ruzi grass, Arabidopsis thaliana Col-0 and tomato at 10, 5 and 5 μL -1 airspace, respectively. In vivo tests were carried out under greenhouse conditions using M. heveae inoculum fumigated soil that had been inoculated with R. microporus inoculum. After which, all seven treatments were compared. Significant differences were observed with a disease score at 150 d after treatment. Biofumigation by M. heveae showed great suppression of the disease. Biocontrol treatments; RMH40 (40 g kg -1 M. heveae inoculum) and RMH80 (80 g kg -1 M. heveae inoculum) were not found to be significantly different when compared with fungicide treatment (RT) and the non-infected control, but results were found to be significantly different from R. microporus infested (R) treatment. RMH40 and RMH80 revealed a low disease scores with a high survival rate of rubber tree seedling at 100 %, while R treatment showed the highest disease score of 4.8 ± 0.5 with a survival rate of rubber tree seedling at 25 %. The infected roots, appearing as a white colour. We have concluded that the bioactive VOCs of M. heveae would be an alternative method for the control of white root rot disease in rubber trees. Copyright © 2017 British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  18. Synthesis, crystal structure and magnetic studies of tetranuclear hydroxo and ligand bridged [Co4(μ3-OH)2(μ2-dea)2(L-L)4]4Cl·8H2O [L-L = 2,2'-bipyridine or 1,10-phenanthroline] complexes with mixed valence defect dicubane core.

    Science.gov (United States)

    Siddiqi, Zafar A; Siddique, Armeen; Shahid, M; Khalid, Mohd; Sharma, Prashant K; Anjuli; Ahmad, Musheer; Kumar, Sarvendra; Lan, Yanhua; Powell, Annie K

    2013-07-14

    X-ray crystallography of the title complexes indicates a discrete mixed valence (Co2(II)-Co2(III)) defect dicubane molecular unit where each cobalt nucleus attains a distorted octahedral geometry. The α-diimine (L-L) chelator coordinated to each cobalt ion stops further polymerization or nuclearization. The water molecules in the lattice play a crucial role in the formation of the supramolecular architectures. Magnetic data were analyzed using the effective spin-1/2 Hamiltonian approach and the parameters are, J = 115(6) K, ΔJ = -57.0(1.2) K, g(xy) = 3.001(25), and g(z) = 7.214(7) for 1 and J = 115(12) K, ΔJ = -58.5(2.5) K, g(xy) = 3.34(5), and g(z) = 6.599(12) for 2 suggesting that only the g matrices are prone to the change of α-diimine chelator.

  19. Adjustment and start-up of an irradiator self shielding model Isogamma LL.CO. in the Centre of Technological Applications and Nuclear Development; Ajuste y puesta en marcha en el centro de aplicaciones tecnologicas y desarrollo nuclear de un irradiador autoblindado modelo Isogamma LL.CO.

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Dania Soguero; Ardanza, Armando Chavez, E-mail: sdania@ceaden.edu.cu [Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN), La Habana (Cuba)

    2013-07-01

    This paper describes the process of installation of a self-shielded irradiator category I, model ISOGAMMA LL.Co of {sup 60}Co, with a nominal 25 kCi activity, rate of absorbed dose 8 kG/h and 5 L workload. The stages are describe step by step: import, the customs procedure which included the interview with the master of the vessel transporter, the monitoring of the entire process by the head of radiological protection of the importing Center, control of the levels of surface contamination of the shipping container of the sources before the removal of the ship, the supervision of the national regulatory authority and the transportation to the final destination. Details of assembling of the installation and the opening of the container for transportation of supplies is outlined. The action plan previously developed for the case of occurrence of radiological successful events is presented, detailing the phase of the load of radioactive sources by the specialists of the company selling the facility (IZOTOP). Finally describes the setting and implementation of the installation and the procedure of licensing for exploitation.

  20. PR-10 proteins as potential mediators of melatonin-cytokinin cross-talk in plants: crystallographic studies of LlPR-10.2B isoform from yellow lupine.

    Science.gov (United States)

    Sliwiak, Joanna; Sikorski, Michal; Jaskolski, Mariusz

    2018-04-06

    LlPR-10.2B, a Pathogenesis-related class 10 (PR-10) protein from yellow lupine (Lupinus luteus) was crystallized in complex with melatonin, an emerging important plant regulator and antioxidant. The structure reveals two molecules of melatonin bound in the internal cavity of the protein, plus a very well-defined electron density near the cavity entrance, corresponding to an unknown ligand molecule comprised of two flat rings, which is most likely a product of melatonin transformation. In a separate LlPR-10.2B co-crystallization experiment with an equimolar mixture of melatonin and trans-zeatin, which is a cytokinin phytohormone well recognized as a PR-10-binding partner, a quaternary 1 : 1 : 1 : 1 complex was formed, in which one of the melatonin-binding sites has been substituted with trans-zeatin, whereas the binding of melatonin at the second binding site and binding of the unknown ligand are undisturbed. This unusual complex, when compared with the previously described PR-10/trans-zeatin complexes and with the emerging structural information about melatonin binding by PR-10 proteins, provides intriguing insights into the role of PR-10 proteins in phytohormone regulation in plants, especially with the involvement of melatonin, and implicates the PR-10 proteins as low-affinity melatonin binders under the conditions of elevated melatonin concentration. Atomic coordinates and processed structure factors corresponding to the final models of the LlPR-10.2B/melatonin and LlPR-10.2B/melatonin + trans-zeatin complexes have been deposited with the Protein Data Bank (PDB) under the accession codes 5MXB and 5MXW. The corresponding raw X-ray diffraction images have been deposited in the RepOD Repository at the Interdisciplinary Centre for Mathematical and Computational Modelling (ICM) of the University of Warsaw, Poland, and are available for download with the following Digital Object Identifiers (DOI): https://doi.org/10.18150/repod.9923638 and https://doi.org/10

  1. Crustal thermal state and origin of silicic magma in Iceland: the case of Torfajökull, Ljósufjöll and Snæfellsjökull volcanoes

    Science.gov (United States)

    Martin, E.; Sigmarsson, O.

    2007-05-01

    Pleistocene and Holocene peralkaline rhyolites from Torfajökull (South Iceland Volcanic Zone) and Ljósufjöll central volcanoes and trachytes from Snæfellsjökull (Snæfellsnes Volcanic Zone) allow the assessment of the mechanism for silicic magma genesis as a function of geographical location and crustal geothermal gradient. The low δ18O (2.4‰) and low Sr concentration (12.2 ppm) measured in Torfajökull rhyolites are best explained by partial melting of hydrated metabasaltic crust followed by major fractionation of feldspar. In contrast, very high 87Sr/86Sr (0.70473) and low Ba (8.7 ppm) and Sr (1.2 ppm) concentrations measured in Ljósufjöll silicic lavas are best explained by fractional crystallisation and subsequent 87Rb decay. Snæfellsjökull trachytes are also generated by fractional crystallisation, with less than 10% crustal assimilation, as inferred from their δ18O. The fact that silicic magmas within, or close to, the rift zone are principally generated by crustal melting whereas those from off-rift zones are better explained by fractional crystallisation clearly illustrates the controlling influence of the thermal state of the crust on silicic magma genesis in Iceland.

  2. Measurement of jets production in association with a Z boson and in the search for the SM Higgs boson via H {yields} {tau}{tau} {yields} ll + 4{nu} with ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Psoroulas, Serena

    2012-10-15

    Three measurements focussing on the understanding of jet final states in ATLAS, in dijet, Z and Higgs boson candidate events, using data corresponding to an integrated luminosity of 35 pb{sup -1} in 2010 and 4.7 fb{sup -1} in 2011, are presented. In the first part, a calibration method, based on the transverse momentum balance in dijet events, is described. The method is used to estimate the uncertainty of the jet energy scale in the forward region. The results show that the parton shower models are limited in reproducing the results in data, mostly for jets of low transverse momentum. In the second part, the differential cross section measurement of the Z{yields}ll+jets process is reported. Phase space regions not been previously studied at other experiments are investigated. The models used for the theory predictions provide a good description of the data, within the relative uncertainties. In the last part, two contribution to the Higgs searches in the H {yields}{tau}{tau} channel are shown: the modelling of the Z{yields}{tau}{tau} background, and the modelling of jet final states. The Z{yields}{tau}{tau} background is derived from data and validated in the H{yields}{tau}{tau}{yields}ll+4{nu} channel. The modelling of jet final states in simulations is in good agreement with the data, when low-energy pile-up effects are subtracted.

  3. Van Bölge Eğitim ve Araştırma Hastanesi\\'nde Giardia intestinalis ve Entamoeba histolytica/dispar prevalansı: Dört yıllık izlem

    OpenAIRE

    Bayram, Yasemin; Parlak, Mehmet; Çıkman, Aytekin

    2013-01-01

    Amaç: Çalışmada dört yıllık sürede Giardia intestinalis ve Entemoeba histolytica/ Entemoeba dispar saptanma oranı, yıllar göre dağılımı ile yaş grupları ve cinsiyete göre dağılımının retrospektif olarak belirlenmesi amaçlanmış­tır. Gereç ve yöntem: Ocak 2008 ile Aralık 2011 tarihleri arasında laboratuvarımıza gönderilen 9911 dışkı örneği parazitolojik yönden incelenmiştir. Taze dışkı örneklerinde Entamoeba sp., Giardia trofozoit ve kistlerinin mikrosko­bik teşhisi i...

  4. Potencial biotécnico do sarandi-branco (Phyllanthus sellowianus Müll. Arg. e vime (Salix viminalis L. para revegetação de margens de cursos de água

    Directory of Open Access Journals (Sweden)

    Fabrício Sutili Jaques

    2004-01-01

    Full Text Available Even with planning and careful use of natural resources, and specially in the case of water courses, some areas are negatively modified, due to losing of margin or hillside stability, leading to erosions and slides. On this way, revegetation and stabilization techniques are imposing tasks to these areas. Some non expensive and easy biological techniques are already known, resting to investigate the applicability of adequate materials to each area, as well as biotechnical value of local native species. This works deals with investigating, on field situation, the rooting stick capability of two different species, that are common on water courses edges of the studied region: ‘sarandi-branco’ (Phyllanthus sellowianus Müll. Arg. and ‘vime’ (Salix viminalis L.. The experiment was developed on eroded margin of ‘Guarda-mor’ stream, in central area of ‘Rio Grande do Sul’ State, Brazil. The sticks used were from different parts of branches (base, half and tip. Sixty day after planting, the rooting was evaluated, being found a good revegetation capability of both species. On ‘sarandibranco’ sticks, the rooting reached 78%, being significantly higher than on ‘vime’ sticks (69%. To both species, the rooting rose up with the proximity of water level and with increasing diameter of sticks (base > half > tip.

  5. Limit of ratio of consecutive terms for general order-k linear homogeneous recurrences with constant coefficients

    International Nuclear Information System (INIS)

    Fiorenza, Alberto; Vincenzi, Giovanni

    2011-01-01

    Research highlights: → We prove a result true for all linear homogeneous recurrences with constant coefficients. → As a corollary of our results we immediately get the celebrated Poincare' theorem. → The limit of the ratio of adjacent terms is characterized as the unique leading root of the characteristic polynomial. → The Golden Ratio, Kepler limit of the classical Fibonacci sequence, is the unique leading root. → The Kepler limit may differ from the unique root of maximum modulus and multiplicity. - Abstract: For complex linear homogeneous recursive sequences with constant coefficients we find a necessary and sufficient condition for the existence of the limit of the ratio of consecutive terms. The result can be applied even if the characteristic polynomial has not necessarily roots with modulus pairwise distinct, as in the celebrated Poincare's theorem. In case of existence, we characterize the limit as a particular root of the characteristic polynomial, which depends on the initial conditions and that is not necessarily the unique root with maximum modulus and multiplicity. The result extends to a quite general context the way used to find the Golden mean as limit of ratio of consecutive terms of the classical Fibonacci sequence.

  6. Sensitivity of the ATLAS experiment to discover the decay H{yields} {tau}{tau} {yields}ll+4{nu} of the Standard Model Higgs Boson produced in vector boson fusion

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Martin

    2011-05-17

    A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H{yields} {tau}{tau}{yields} ll+4{nu} is presented. The study is based on simulated proton-proton collisions at a centre-of-mass energy of 14 TeV. For the first time the discovery potential is evaluated in the presence of additional proton-proton interactions (pile-up) to the process of interest in a complete and consistent way. Special emphasis is placed on the development of background estimation techniques to extract the main background processes Z{yields}{tau}{tau} and t anti t production using data. The t anti t background is estimated using a control sample selected with the VBF analysis cuts and the inverted b-jet veto. The dominant background process Z{yields}{tau}{tau} is estimated using Z{yields}{mu}{mu} events. Replacing the muons of the Z{yields}{mu}{mu} event with simulated {tau}-leptons, Z{yields}{tau}{tau} events are modelled to high precision. For the replacement of the Z boson decay products a dedicated method based on tracks and calorimeter cells is developed. Without pile-up a discovery potential of 3{sigma} to 3.4{sigma} in the mass range 115 GeV

  7. Sensitivity of the ATLAS experiment to discover the decay H→ ττ →ll+4ν of the Standard Model Higgs Boson produced in vector boson fusion

    International Nuclear Information System (INIS)

    Schmitz, Martin

    2011-01-01

    A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H→ ττ→ ll+4ν is presented. The study is based on simulated proton-proton collisions at a centre-of-mass energy of 14 TeV. For the first time the discovery potential is evaluated in the presence of additional proton-proton interactions (pile-up) to the process of interest in a complete and consistent way. Special emphasis is placed on the development of background estimation techniques to extract the main background processes Z→ττ and t anti t production using data. The t anti t background is estimated using a control sample selected with the VBF analysis cuts and the inverted b-jet veto. The dominant background process Z→ττ is estimated using Z→μμ events. Replacing the muons of the Z→μμ event with simulated τ-leptons, Z→ττ events are modelled to high precision. For the replacement of the Z boson decay products a dedicated method based on tracks and calorimeter cells is developed. Without pile-up a discovery potential of 3σ to 3.4σ in the mass range 115 GeV H -1 . In the presence of pile-up the signal sensitivity decreases to 1.7σ to 1.9σ mainly caused by the worse resolution of the reconstructed missing transverse energy.

  8. The HILW-LL (high- and intermediate-level waste, long-lived) disposal project: working toward building the Cigeo Industrial Centre for Geological Disposal; Le projet HA-MAVL: vers la realisation du centre industriel de stockage geologique Cigeo

    Energy Technology Data Exchange (ETDEWEB)

    Labalette, Th. [Agence Nationale pour la Gestion des Dechets Radioactifs - ANDRA, Dir. des Projets, 92 - Chatenay Malabry (France)

    2011-02-15

    The French Act of 28 June 2006 identifies reversible disposal in deep geological facilities as the benchmark solution for long-term management of high-level waste (HLW) and for intermediate-level long-lived waste (ILW-LL). The Act tasks ANDRA (national agency for the management of radioactive wastes) with the pursuit of studies and research on the choice of a site and the design of the repository, with a view to examining the licence application in 2015 and, provided that the licence is granted, to make the facility operational by 2025. At the end of 2009, ANDRA submitted to the Government its proposals regarding the site and the design of the Industrial Centre for Geological Disposal, known as CIGEO. With the definition of a possible area for the construction of underground disposal facilities, one of the key stages in the project has been achieved. The choice of a surface site will be validated following the public consultation scheduled for the end of 2012. The project is now on the point of entering the definition stage (preliminary design). CIGEO will be a nuclear facility unlike any other. It will be built and operated for a period of over 100 years. For it to be successful, the project must meet certain requirements related to its integration in the local area, industrial planning, safety and reversibility, while also controlling costs. Reversibility is a very important concept that will be defined by law. It is ANDRA's responsibility to ensure that a reasonable balance is found between these different concerns. (author)

  9. chronic Lymphocytic Leukemia (cLL)

    African Journals Online (AJOL)

    Slightly increased diploic space with hair on end appearance (at occipital lobe) was seen on skull x-ray. Rugger Jersey sign was positive at distal end humerus with osteoporosis. X-ray of femur was normal. These findings were suggestive of early bone manifestation of CLL. Abdominal ultrasound showed hepatomegaly ...

  10. Keep Searching and You’ll Find

    DEFF Research Database (Denmark)

    Laursen, Keld

    2012-01-01

    This article critically reviews and synthesizes the contributions found in theoretical and empirical studies of firm-level innovation search processes. It explores the advantages and disadvantages of local and non-local search, discusses organizational responses, and identifies potential exogenous...... different search strategies, but end up with very similar technological profiles in fast-growing technologies. The article concludes by highlighting what we have learnt from the literature and suggesting some new avenues for research....

  11. Diffusione molecolare neLl' alta atmosfera

    Directory of Open Access Journals (Sweden)

    C. ARDUINI

    1963-06-01

    Full Text Available Le perturbazioni indotte nell'alta atmosfera dall'emissione,
    a mezzo di razzi sonda, di nubi di vapori estranei sono un utile
    mezzo per lo studio simultaneo di alcune caratteristiche fisiche e dinamiche
    degli alti strati.
    La presente relazione illustra in breve i principi di alcune tecniche
    per la misura del coefficiente di diffusione binaria tra l'aria e il vapore
    della nube artificiale.

  12. They'll Be Suing You.

    Science.gov (United States)

    Weeks, Kent M.

    1980-01-01

    Few claims for negligence or misrepresentation against higher education have been sustained, but several important cases in lower education have provided a framework for future litigation. It is noted that the students ultimately lost, but educators should not be lulled. The development of a new tort such as educational malpractice takes years.…

  13. Who'll pay the electricity bill?

    International Nuclear Information System (INIS)

    Roche, P.

    1989-01-01

    Nuclear power will be protected from the vagaries of the free market by requiring the 12 privatised distribution companies to take around 15-20% of their power from non-fossil (i.e. nuclear) sources. The Electricity Bill also requires producers of fossil-fuelled electricity to charge a compulsory levy which will be used to finance the non-fossil quota. The extra cost of generating electricity by nuclear means compared with the alternatives will be recouped via the 'levy' after the new PWRs have come into operation. Producers of power which is neither nuclear nor fossil will not be required to make this levy, so renewable energies may gain a small competitive advantage. The financial implications of privatisation have not been fully clarified, especially regarding nuclear power with its associated expenses of radioactive waste disposal and decommissioning. Energy efficiency may be encouraged by the Bill, but competition may not result from the Bill. (author)

  14. I'll be seeing u

    International Nuclear Information System (INIS)

    Clark, D.

    1996-01-01

    With uranium prices now having risen by more than 70% over the past year and a half, most buyers are asking themselves how high will the market go and will these higher prices be sustainable. Part of the answer may come from looking at why the market is moving higher now to begin with. Looking into the future, though, the current volatility in the uranium market may give way to a period of long-term stability. (author). 3 figs

  15. We'll Paint the Octopus Red.

    Science.gov (United States)

    Stuve-Bodeen, Stephanie

    This children's book tells the story of a little girl who has a new baby brother with Down syndrome. Her contemplation of the advantages and disadvantages of having a sibling is highlighted. When she finds out the baby has Down syndrome, her initial reaction is that the baby won't be able to do all the wonderful things she has thought they would…

  16. I'll Bring the Popcorn

    Science.gov (United States)

    Blickenstaff, Jacob Clark

    2011-01-01

    Movie clips can provide data for content-rich problem solving, show students exotic phenomena, allow them to apply science concepts in a new setting, and foster connections between science and the humanities. Though the latest release will have the advantage of pop-culture currency, films old enough to be released on DVD give teachers more…

  17. (l+l)= CP,(~)N.

    African Journals Online (AJOL)

    The use of mathematical'models for educational planning has gained prominence in recent times as a ... In this paper Markov chain model for manpower planning is used to model the flow of students in the ..... Mathematical Physics (2nd ed.) ...

  18. The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.

    Science.gov (United States)

    Tietjen, Ian; Ngwenya, Barbara N; Fotso, Ghislain; Williams, David E; Simonambango, Sundana; Ngadjui, Bonaventure T; Andersen, Raymond J; Brockman, Mark A; Brumme, Zabrina L; Andrae-Marobela, Kerstin

    2018-01-30

    Current HIV therapies do not act on latent cellular HIV reservoirs; hence they are not curative. While experimental latency reversal agents (LRAs) can promote HIV expression in these cells, thereby exposing them to immune recognition, existing LRAs exhibit limited clinical efficacy and high toxicity. We previously described a traditional 3-step medicinal plant regimen used for HIV/AIDS management in Northern Botswana that inhibits HIV replication in vitro. Here we describe use of one component of the regimen that additionally contains novel phorbol esters possessing HIV latency-reversal properties. We sought to document experiences of traditional medicine users, assess the ability of traditional medicine components to reverse HIV latency in vitro, and identify pure compounds that conferred these activities. Experiences of two HIV-positive traditional medicine users (patients) were documented using qualitative interview techniques. Latency reversal activity was assessed using a cell-based model (J-Lat, clone 9.2). Crude plant extracts were fractionated by open column chromatography and reverse-phase HPLC. Compound structures were elucidated using NMR spectroscopy and mass spectrometry. Patients using the 3-step regimen reported improved health over several years despite no reported use of standard HIV therapies. Crude extracts from Croton megalobotrys Müll Arg. ("Mukungulu"), the third component of the 3-step regimen, induced HIV expression in J-lat cells to levels comparable to the known LRA prostratin. Co-incubation with known LRAs and pharmacological inhibitors indicated that the active agent(s) in C. megalobotrys were likely to be protein kinase C (PKC) activator(s). Consistent with these results, two novel phorbol esters (Namushen 1 and 2) were isolated as abundant components of C. megalobotrys and were sufficient to confer HIV latency reversal in vitro. We have identified novel LRAs of the phorbol ester class from a medicinal plant used in HIV/AIDS management

  19. Clifford Continuous Wavelet Transforms in Ll0,2 and Ll0,3

    International Nuclear Information System (INIS)

    Bernstein, S.

    2008-01-01

    We consider Clifford-valued functions defined on R n . From the viewpoint of square integrable group representations a continuous wavelet transform is an irreducible continuous unitary representation of the affin group on the real line but also on R n . We will demonstrate that different Clifford continuous wavelet transforms can be obtained inside the calculus with similar properties than the real valued transform. Nevertheless, the Clifford wavelet transform is neither just a special vector transform nor just a wavelet transform applied to each component of the Clifford-valued function.

  20. 29 March 2012 - Austrian Niederösterreich Governor E. Pröll with Klubobmann and Chairman of EBG MedAustron GmbH Council K. Schneeberger, Director General for Cultural Policy Amabssador M.Eichtinger and Permanent Representative of Austria to the UNO and Austrian Delegate to CERN Council Ambassador C. Strohal in the MedAustron facility at CERN building 184.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    CERN-HI-1203078 01 - 13: visit of LINAC 3 with M. Benedikt CERN-HI-1203078 14 - 20: in the Roy Billinge room CERN-HI-1203078 21- 22: visit of the LEIR accelerator in building 354 CERN-HI-1203078 23 - 55: signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss CERN-HI-1203078 56 - 99: in building 184, Governor Pröll and CERN Director-General R. Heuer switch on the MedAustron ion source to produce the proton beam; visit MedAustron facility. CERN-HI-1203078 32:from left to right: Klubobmann and Chairman of EBG MedAustron GmbH Council K. Schneeberger; Director-General R. Heuer;Niederösterreich Governor E. Pröll;Head of International Relations F. Pauss;Permanent Representative of Austria to the UNO and Austrian Delegate to CERN Council Ambassador C. Strohal.

  1. Personal Storytelling and Narrative as a Means for Climate Scientists to Engage and Inform Public Audiences - Illustrated by the Play '2071 - The World We'll Leave Our Grandchildren' Comissioned by the Royal Court Theatre, London and the Deutsches Schauspielhaus, Hamburg

    Science.gov (United States)

    Rapley, C. G.

    2015-12-01

    In order to engage greater public interest in science it is necessary to move beyond the traditional academic "information deficit" mode of communication, with its emphasis on the delivery and explantion of 'facts'. This is especially the case for topics such as climate science, which have the potential to provoke strong conscious or unconscious emotional and ideological audience reactions. The use of personalised narrative and storytelling offers a means to draw in non-experts in a way that overcomes barriers of disinterest or prejudice. The talk will address the role of climate scientists in communicating within the public square, and will use the play '2071 - The World We'll Leave Our Grandchildren" as an example of how theatre can provide an effective means of communicating complex and provocative knowledge and understanding. The play was commissioned by the Royal Court Theatre, London and the Deutshes Schauspielhaus, Hamburg. It received positive reviews and sold out at the London venue.

  2. Search for the Standard Model Higgs Boson and Test of CP Invariance in Vector-Boson Fusion Production of the Higgs Boson in the Fully Leptonic H->tautau->ll4nu Final State in Proton-Proton Collisions with the ATLAS Detector at the LHC

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00336635

    2016-11-04

    Results of a search for fully leptonic H->tautau->ll4nu decays are presented, based on the set of proton–proton collision data recorded by the ATLAS experiment at the LHC during 2012. The data corresponds to an integrated luminosity of 20.3 fb^-1 at the centre-of-mass energy of sqrt(s)=8 TeV. An excess of events over the expected background from other Standard Model processes is found. The observed (expected) significance is 2.7 (1.3) standard deviations. The measured signal strength, normalised to the Standard Model expectation, is mu =2.1+1.0-0.8. This is consistent with the predicted Yukawa coupling strength in the Standard Model. The analysis contributes to the combined search for H->tautau including also the fully hadronic and semi-leptonic final states. The combined analysis provides evidence for the direct coupling of the Higgs boson to fermions with the observed (expected) significance of 4.5 (3.4) standard deviations. Furthermore a test of CP invariance in Higgs boson production via vector-boson fu...

  3. Predictions for Ξ{sub b}{sup -} → π{sup -}(D{sub s}{sup -}) Ξ{sub c}{sup 0}(2790) (Ξ{sub c}{sup 0}(2815)) and Ξ{sub b}{sup -} → anti ν{sub l}l Ξ{sub c}{sup 0}(2790) (Ξ{sub c}{sup 0}(2815))

    Energy Technology Data Exchange (ETDEWEB)

    Pavao, R.P.; Nieves, J. [Centro Mixto CSIC-Universidad de Valencia, Instituto de Fisica Corpuscular (IFIC), Institutos de Investigacion de Paterna, Valencia (Spain); Liang, Wei-Hong [Guangxi Normal University, Department of Physics, Guilin (China); Oset, E. [Centro Mixto Universidad de Valencia-CSIC, Departamento de Fisica Teorica y IFIC, Institutos de Investigacion de Paterna, Valencia (Spain)

    2017-04-15

    We have performed calculations for the nonleptonic Ξ{sub b}{sup -} → π{sup -} Ξ{sub c}{sup 0}(2790) (J = (1)/(2)) and Ξ{sub b}{sup -} → π{sup -} Ξ{sub c}{sup 0}(2815) (J = (3)/(2)) decays and the same reactions replacing the π{sup -} by a D{sub s}{sup -}. At the same time we have also evaluated the semileptonic rates for Ξ{sub b}{sup -} → anti ν{sub l}l Ξ{sub c}{sup 0}(2790) and Ξ{sub b}{sup -} → anti ν{sub l}l Ξ{sub c}{sup 0}(2815). We look at the reactions from the perspective that the Ξ{sub c}{sup 0}(2790) and Ξ{sub c}{sup 0}(2815) resonances are dynamically generated from the pseudoscalar-baryon and vector-baryon interactions. We evaluate ratios of the rates of these reactions and make predictions that can be tested in future experiments. We also find that the results are rather sensitive to the coupling of the Ξ{sub c}{sup *} resonances to the D{sup *}Σ and D{sup *}Λ components. (orig.)

  4. Why You'll Never Catch Smallpox

    Science.gov (United States)

    Cutler, Marianne; Lawrence, Liz

    2016-01-01

    In this article, Marianne Cutler and Liz Lawrence describe in more detail the opportunities for "working scientifically" provided by this new Association for Science Education (ASE) resource, which was introduced in the previous issue, along with some of the feedback from teachers who have trialled the resources. [This article was…

  5. "We'll turn your water into Coca-Cola"

    NARCIS (Netherlands)

    Vos, de Rosanne; Köhne, Michiel; Roth, Dik

    2018-01-01

    This article discusses land control strategies and practices for development of large-scale oil palm plantations in West Kalimantan, Indonesia. In oil palm and "land grab" literature, much attention is paid to potential contributions of free, prior, and informed consent procedures. However, this

  6. Cytotoxic and Antioxidant Activities of Antidesma thwaitesianum Müll ...

    African Journals Online (AJOL)

    residue left after maceration of fresh fruits (RFW) showed moderate superoxide radical-scavenging activity relative ... become purplish red to dark purple depending on the level of ... mamao juice and wine, exhibited antioxidant potential ... regarding health benefits of Antidesma .... amount of total phenolic content, which was.

  7. The concept of humanistic base texts / Linnart Mäll

    Index Scriptorium Estoniae

    Mäll, Linnart

    2003-01-01

    Ettekanne sümpoosionilt: Gemeinsames Symposium der Evangelisch-Theologischen Fakultät der Universität Tartu, der Estnischen Studiengesellschaft für Morgenlandkunde und der Deutschen Religionsgeschichtlichen Studiengesellschaft. Tartu, 2001

  8. Saaremaal valmib terasmehe häll / Aivo Vahemets

    Index Scriptorium Estoniae

    Vahemets, Aivo

    2005-01-01

    Eesti ettevõttes Michelle OÜ kaubamärgi all Inox Disain Lab toodetakse roostevabast terasest konstruktsiooniga voodeid. Ettevõtet juhib Jaak Kangro. Voodinäidised on Tallinnas Pärnu mnt. 22 ateljees või interneti koduleheküljel www.inox.ee

  9. Human cathelicidin LL-37 – Does it influence the homeostatic ...

    Indian Academy of Sciences (India)

    ELŻBIETA KOZŁOWSKA

    2018-04-19

    Apr 19, 2018 ... 37 concentration to be analyzed using one-way ANOVA analysis and the post ..... Meta-analysis of cytokine alterations in schizophrenia: clinical status and ... diabetes mellitus and pulmonary tuberculosis. Exp. Ther. Med. 9.

  10. Liikeidean mallintaminen Business Model Canvas -menetelmällä

    OpenAIRE

    Kuosmanen, Tuomas; Haataja, Henri

    2013-01-01

    Tämän opinnäytetyön tarkoituksena oli kehittää liiketoimintamalleja yrityksen suunnitteluvaiheessa. Opinnäytetyössä asiaa selvitettiin oman harrastustoiminnan pohjalta käyttäen Business Model Canvas:ia ja selvitettiin, millaisia liiketoimintamalleja viitekehyksessä olisi mahdollista toteuttaa. Työn aihe löytyi harrastuksen kautta pohtimalla sen liiketoiminnallista puolta. Suomessa toimii useita rullalautailualan internetkauppoja ja suurimmissa kaupungeissa on alan liikkeitä. Rulla...

  11. What we'll find inside the atom

    CERN Multimedia

    Lederman, Leon

    2008-01-01

    What will scientists see with the LHC? The machine may well reveal a new world, a gift to the 21st century; although the machine is now just starting to do its work, its true sharpness won't become apparent for several years. (4 pages + photos)

  12. Raamat sõja seadustest / Linnart Mäll

    Index Scriptorium Estoniae

    Mäll, Linnart

    2001-01-01

    Vana-Hiina sõjateoreetikute Sun Zi ja Sun Bini raamatust: Sun, Zi ; Sun, Bin. Sõja seadused / klassikalisest hiina keelest tõlkinud ja kommenteerinud Märt Läänemets. Tln. : Eesti Keele Sihtasutus, 2001. (Sõjandusvaramu. Klassika)

  13. Eat all that and you'll be sick.

    Science.gov (United States)

    Dent, Emma

    2008-10-02

    Up to 500,00 people could have undiagnosed diabetes in England. As many as one in two people who have diabetes may not be coded properly under payment by results. Children born to women who have diabetes have five times the average still birth rate.

  14. Lupus nephritis . Part ll. A clinicopathological correlation and study ...

    African Journals Online (AJOL)

    ... often with uncommon pathogens, were the most important causes of death. Serum creatinine values and creatinine clearance at the time of biopsy or ... persistent hypertension, histological classification IV, and high activity scores were ...

  15. You take the profit, we'll keep the waste

    Energy Technology Data Exchange (ETDEWEB)

    Mayman, J

    1989-07-01

    Environmentalists and farmers in Western Australia are opposing the lucrative sand-mining industry, claiming that Australia is enjoying a few of the benefits and most of the costs by agreeing to assume responsibility for tens of thousands of tonnes of radioactive waste likely to emit radiation for several billions of year. ill.

  16. Vitamin D and LL-37 in children with pneumonia | Albanna ...

    African Journals Online (AJOL)

    Egyptian Journal of Pediatric Allergy and Immunology (The). Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 8, No 2 (2010) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file ...

  17. Symposium LL: Nanowires--Synthesis Properties Assembly and Application

    Science.gov (United States)

    2010-09-10

    J. C. Wang, Y. C. Chang, H. C. Hsu, Tzer-En Nee, L. J. Chen, and J. H. He, 2008 J. Nanosci. Nanotechnol, 8, 3363-3368. [2] Y. Ishikawa , M. Okamoto...Silicon Nanowires. Kaoru Kaiiwara1, Masato Ara2 and Hirokazu Tada1; 1 Division of Materials Physics, Graduate school of Engineering Science, Toyonaka

  18. Kuhu küll raha kasvama panna? / Silvia Viidik

    Index Scriptorium Estoniae

    Viidik, Silvia, 1972-

    2010-01-01

    Bloomberg korraldas oma kõige professionaalsemate klientide küsitluse parimate ja halvimate investeerimisvõimaluste väljaselgitamiseks. Küsitluse kohaselt on parimad investeerimise sihtkohad Brasiilia, Hiina ja India, mõnevõrra vähem eelistatakse USA-d. Kehvemateks piirkondadeks peeti Euroopa Liitu, Jaapanit, Suurbritanniat ja ka USA-d. Enim võib teenida aktsiaturgudel ja toorainetes

  19. On Testudo emys Schleg. & Müll. and its affinities

    NARCIS (Netherlands)

    Lidth de Jeude, van Th.W.

    1896-01-01

    In 1840 ¹) Schlegel and Sal. Müller described in number 2 of the zoological part of » Verhandelingen over de natuurlijke geschiedenis der Nederlandsche Overzeesche Bezittingen” a new species of Testudo, which differed from the other species of this genus by its broad, slightly elevated shell, and by

  20. Oh, the Economics You'll Find in Dr. Seuss!

    Science.gov (United States)

    Miller, Ben; Watts, Michael

    2011-01-01

    The authors list economic concepts and issues covered in the children's books published by Theodor Geisel and discuss his treatment of concepts that appear most often and that are treated in greater depth. Some concepts are sophisticated and taught as formal concepts only in college-level economics courses. Others are basic and used in economics…

  1. LL § 16 E i kritisk EU-retlig belysning

    DEFF Research Database (Denmark)

    Werlauff, Erik; Rønfeldt, Thomas

    2013-01-01

    Artiklen analyserer ligningslovens § 16 E om hovedaktionærbeskatning af udlodninger og konkluderer, at reglen i EU-retlig forstand udgør en restriktion, der ikke kan retfærdiggøres af almene hensyn, og som derfor må antages at være EU-stridig. Danmark bruger sine selskabsregler til at håndhæve et...

  2. Enraizamento de estacas de Sebastiania schottiana Müll. Arg.

    OpenAIRE

    Frassetto,Eduardo Garcia; Franco,Elci Terezinha Henz; Kielse,Paula; Amaral,Vanessa Fiad Martins do

    2010-01-01

    O pouco domínio dos processos envolvidos no enraizamento de estacas de diversas espécies florestais tem sido um fator limitador para a produção de mudas via propagação vegetativa, impedindo possíveis ganhos econômicos e ecológicos nas atividades de reflorestamento e recuperação de áreas degradadas. O objetivo deste estudo foi verificar o potencial de enraizamento de estacas de Sebastiania schottiana, submetidas a diferentes doses e tempos de imersão em produto comercial Orgasol® FTS (composto...

  3. 7 CFR 29.1084 - Whitish-lemon (LL).

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER... results during wet growing seasons when rain leaches or washes out the yellow color from the leaf. Any...

  4. checkCIF/PLATON report Datablock: ll5182

    Indian Academy of Sciences (India)

    Calculated. Reported. Volume ... PLAT094_ALERT_2_C Ratio of Maximum / Minimum Residual Density .... 2.20 Report ... outliers and unusual parameters, but every test has its limitations and alerts that are not important in a particular case ...

  5. Treatment of LL and ML liquid radwaste. The SGN experience

    International Nuclear Information System (INIS)

    Tchemitcheff, E.; Roux, P.

    1993-01-01

    SGN (Societe Generale pour les Techniques Nouvells) with considerable know-how and thirty years of feed-back in industrial management of liquid effluents from the entire French nuclear industry, has accordingly completed many low- and medium-level liquid radwaste treatment, relying on two major industrially proven technologies: evaporation and chemical coprecipitation. The low level and medium level radwaste in France and evaluated

  6. I'll knock you when I'm ready

    DEFF Research Database (Denmark)

    Rasmussen, Majken Kirkegaard; Krogh, Peter; Lehoux, Natalie

    2012-01-01

    , and the qualities of suggestive interactions that mediate communication. We introduce Knock-Knock as a novel, shape-changing communication medium, and use it as a rhetorical tool to reflect upon the notion of media richness. In doing so, we highlight the value of meaning and language creation that suggestive...

  7. REGULATION OF CHLOROPHY LL DEGRADATION IN PLANT TISSUES

    Directory of Open Access Journals (Sweden)

    Syvash O. O.

    2017-06-01

    Full Text Available The purpose of the review was to analyze the basic biochemical processes leading to the chlorophyll degradation and ways to control this process in plant product storage. First of all, this is a complex of enzymatic reactions starting with the hydrolysis of chlorophyll with the formation of acyclic diterpene phytol and water-soluble chlorophyllide. An alternative primary reaction is the removal of magnesium from the chlorophyll tetrapyrrole ring to form pheophytin with the participation of Mg2+-dechelatase and/or low-molecular Mg2+-dechelating substances. The chlorophyll breakdown can also be caused by free radicals formed in the peroxidase-catalyzed reaction of Н2О2 with phenolic compounds or fatty acids. The unstable product of chlorophyll peroxidation, C132 –hydroxychlorophyll a decomposes to colorless low-molecular compounds. Expression of the genes of chlorophyll catabolism enzymes is controlled by phytohormones. Methods for controlling the pigment decomposition during storage of plant products are associated with the use of activators and inhibitors of chlorophyll decomposition. The best known inductor of the synthesis of catabolic enzymes is ethylene, widely used to accelerate fruit ripening. Gibberellins, cytokinins and nitric oxide, on the contrary, slow down the loss of chlorophyll.

  8. I'll Do It Tomorrow: The Logic of Procrastination

    Science.gov (United States)

    Zarick, Lisa M.; Stonebraker, Robert

    2009-01-01

    College students seem especially adept at procrastination. Large percents report that it causes lower quality papers and projects, lower exam scores and, to a lesser extent, late or missing assignments. Using survey data collected from a broad cross-section of students and faculty we argue that procrastination can be modeled as a logical, albeit…

  9. Geografía de la "ll" en Chile

    OpenAIRE

    Wagner, Claudio; Rosas, Claudia

    2003-01-01

    Este trabajo se propone precisar la magnitud y distribución real de la palatal lateral en Chile, ahora que se cuenta con datos obtenidos de primera mano por medio de encuestas sistemáticas in situ realizadas a lo largo de todo el territorio chileno. El análisis de los datos demuestra que la reducción de la palatal lateral a un número ínfimo de enclaves agrupados en torno a dos pequeñas áreas no hace sino corroborar las noticias que los estudiosos han dado desde fines del siglo XIX acerca del ...

  10. You'll get a charge out of this

    International Nuclear Information System (INIS)

    Koch, G.

    1995-01-01

    Changes occurring in the electric utilities market and the merits and disadvantages of deregulation of the electricity industry were discussed. Deregulation was said to have opened the gas market to competition among producers, aggregators, marketers, shippers, brokers, distributors and wholesale and retail buyers.Among other benefits, deregulation in Canada and the United States boosted production and Canadian gas exports. Retail costs to some U.S. end users were also reduced by one third. While the U.S. government and the Federal Energy Regulatory Commission (FERC) have been making major efforts to deregulate the electricity industry, Canadian efforts in this direction have been relatively minor.To date, greatest strides towards deregulation in Canada have been made in Alberta, where under the new Electric Utilities Act, local distributors will be able to tender contracts for any consumption that requires building new generating capacity. Access to the transmission grid, still owned by big utilities, can be rented by newcomers. Several arguments for further deregulation in Canada have been advanced, among them the need for lower domestic power rates to maintain the competitiveness of Canadian businesses, competition from U.S. generators, and long-term export opportunities to the U.S

  11. Doctest and unittest... now they'll be merrily together

    Directory of Open Access Journals (Sweden)

    2008-06-01

    Full Text Available Testing is a very important discipline to ensure and validate software quality. Python includes two standard modules to perform functional testing. Prior to version 2.4 both tools were unrelated, leading to scattered testing code. From this version on a unittest API is provided by doctest. The present work aims to propose some enhancements to this API in order to achieve a better unittest-doctest integration. Although there are more complex testing tools (e.g. nose which allow performing both kinds of tests, they are outside the scope of this article. Firstly, they are not standard modules. Besides, the intent is to load and execute doctests just like if we were using unittest.

    Even though many types of tests exist these days1, functional testing is very important. Firstly, it validates whether software behavior matches the business rules documented in the software requirements. Besides, for continuously evolving systems and iterative development processes it is also crucial to perform regression testing. Thereby introduced defects are handled as soon as possible and the defect does not propagate to future versions. These tests are also the main building block for test-driven development and extreme programming techniques. A scripting language like Python ought to be aware of this since it is often used to write test scripts (e.g. for Java2 and .NET3. Because of this, the paper also covers the standard modules available nowadays in Python for functional testing.

  12. Enraizamento de estacas de Sebastiania schottiana Müll. Arg. Rooting of Sebastiania schottiana Müll. Arg. cuttings

    Directory of Open Access Journals (Sweden)

    Eduardo Garcia Frassetto

    2010-12-01

    Full Text Available O pouco domínio dos processos envolvidos no enraizamento de estacas de diversas espécies florestais tem sido um fator limitador para a produção de mudas via propagação vegetativa, impedindo possíveis ganhos econômicos e ecológicos nas atividades de reflorestamento e recuperação de áreas degradadas. O objetivo deste estudo foi verificar o potencial de enraizamento de estacas de Sebastiania schottiana, submetidas a diferentes doses e tempos de imersão em produto comercial Orgasol® FTS (composto de aminoácidos e micronutrientes. Estacas basais, medianas e apicais tiveram suas bases imersas em Orgasol® FTS nas doses de 0; 5; 10 e 15mL L-1, durante 1 minuto. O delineamento experimental foi realizado em blocos ao acaso, com três repetições de 20 estacas por parcela. Aos 75 dias, avaliou-se a porcentagem de estacas enraizadas, o comprimento e diâmetro da raiz mais longa. Em um segundo experimento, estacas basais e medianas foram tratadas em 15mL L-1 do produto, durante 0, 15, 30 e 45 minutos. O delineamento experimental foi realizado em blocos ao acaso, com três repetições e 20 estacas por parcela. Aos 150 dias, avaliou-se a porcentagem de estacas enraizadas, massa seca das raízes e o comprimento e diâmetro da raiz mais longa. No primeiro experimento, o aumento da dose do produto promoveu um maior potencial de enraizamento em todos os tipos de estacas, com maior porcentagem de estacas enraizadas no tratamento com 15mL L-1 do produto. No segundo experimento, os maiores potenciais de enraizamento foram observados em estacas basais e medianas tratadas com 15mL L-1 do produto, por 45 minutos. O uso do produto comercial Orgasol® FTS favoreceu a indução de raízes adventícias em estacas de Sebastiania schottiana.The aim of this study was to verify the rooting potential of Sebastiania schottiana cuttings treated with different doses and immersion times in Orgasol® FTS (composed with amino acids and micronutrients. In a first trial, basal, median and apical cuttings had their bases immersed in Orgasol® FTS at levels of 0, 5, 10 and 15mL L-1, for 1 minute. The experimental design was in random blocks, with three replicates and 20 cuttings per plot. At 75 days, the rooted cuttings percentage, the length and diameter of the longest root were evaluated. In a second trial, basal and median cuttings were treated for 0, 15, 30 and 45 minutes in 15mL L-1 of Orgasol® FTS. The experimental design was in random blocks, with three replicates of 20 cuttings per plot. At 150 day, the rooted cuttings percentage, dry roots mass and the length and diameter of the longest root were evaluated. In the first trial, higher levels of product was beneficial to rooting, it was observed the largets rooted cuttings percentage in the treatment with 15mL L-1 of product. In second trial, the higher rooting potential was observed in the basal and median cuttings treated by 45 minutes in 15mL L-1 of product. The use of orgasol® FTS promotes adventitious roots in Sebastiania schottiana cuttings.

  13. Terpenos isolados de Coussarea platyphylla Müll. Arg. (Rubiaceae Terpenes isolated of Coussarea platyphylla Müll. Arg. (Rubiaceae

    Directory of Open Access Journals (Sweden)

    Francieli Casassa Vieira de Araujo

    2009-01-01

    Full Text Available The phytochemical investigation of Coussarea platyphylla led to the isolation of triterpenes betulonic and betulinic acid, monoterpenes monotropein and monotropein salt, the diterpene trans-phytol and esteroids. The structures of the isolated compounds were assigned on the basis of spectroscopic data, including two-dimensional NMR methods. The antiproliferative properties against human cancer cell lines and molluscicidal activity against Biomphalaria glabrata of the crude methanolic extract and of its fractions were investigated.

  14. «I’ll kill him and I’ll eat him!»: Peter Greenaway and the cinematic Trauerspiel

    Directory of Open Access Journals (Sweden)

    Mattia Petricola

    2017-11-01

    Full Text Available The career of British director Peter Greenaway, now more than four decades long, has often been animated by a profound interest in what one may call the aesthetics of death. This is particularly true for his 80s and 90s films, which explore a wide array of strategies for the staging and ritualization of death. In The Cook, the Thief, his Wife & Her Lover (1989, for the first time, this interest takes Greenaway into the territories of the tragic.I propose to rethink the fundamental relationship that Greenaway’s film entertains with the narrative and aesthetic forms of the tragic. More precisely, I suggest to interpret The Cook in the light of the reflections on the Trauerspiel (mourning-play that Walter Benjamin elaborates in The Origin of German Tragic Drama [Ursprung des deutschen Trauerspiels]. After giving a short account of the first macro-section of Benjamin’s essay, I will argue that the opposition between the Thief and the Lover mirrors the Trauerspiel’s opposition between Tyrant and Martyr, that Benjamin regards as one of the conceptual cores of this theatrical form. This, in turn, reflects the presence in the film of a more abstract conflict between two systems for the construction of knowledge and experience. By drawing on Benjamin’s study, I will trace this conflict back to the opposition between nature and books in baroque culture.The battle between the Thief/Tyrant and the Lover/Martyr takes the form of a succession of rites and counter-rites for the (unmaking of social bonds, and the film constructs these rites by clearly referring to the Christian imagination and its subversion. I will contend that the motif of the subversion of the Holy Communion can provide us with a unifying key for the interpretation of the film. From a semiotic perspective, this manipulation consists in the substitution of what our culture constructs as food with its dysphoric counterparts: decay, excrement, and human flesh.

  15. Premilinary studies for optimiziing a protocol for obtaining embryogenic calluses in two rubber (Hevea brasiliensis Mull. Arg clones from different geographical origins Estudios preliminares en la estandarización de un protocolo para la obtención de callos embriogénicos en dos clones de caucho (Hevea brasiliensis Müll. Arg. de diferentes orígenes geográficos

    Directory of Open Access Journals (Sweden)

    Medina S. Marisol

    2006-07-01

    Full Text Available The influence of growth regulators on obtaining friable rubber (Hevea brasiliensis Müll. Arg. calluses with no plant regeneration as investigated. Two clones having different geographical origin were used in all trails carried out in this study: FX 3864 (South-American and PB 254 (Asian. Young leaves and eight- to ten-week-old seed integument from both clones were used as explants in several experiments; they were initially cultured in MH medium (Carron, et ál., 1989, modified MH medium (Montoro, et ál., 1993, 2000 and modified MS medium (Carron, et at,. 1992, no positive response being obtained by days 25 or 50. However, other trials were carried out with the integument in modified MS medium (1962, 0.67 mg/L BAP and 0.66 mg/L 2-4 D being added as medium for initiating embryogenesis, the formation of white, friable calluses being observed by day 25 in the two selected clones. These calluses were sub-cultured in MS supplemented with 0.35 mg/L BAP and 0.2 mg/L 2-4 D as callogenesis expression medium, embryogenic expression being observed in both clones by day 50. Equally friable white calluses were obtained from young leaves in the two clones in MS medium supplemented with 1.0 mg/L BAP, 1.0 mg/L ANA but without IBA and kinetin by day 25. Calluses sub-cultured in the same medium supplemented with 0.5 mg/L BAP and 0.5 mg/L ANA began to show increased friability after 50 days. culture. This work is a partial report of a macro-project for optimising a protocol for rubber (Hevea brasiliensis  multiplication by somatic embryogenesis.Se investigó la influencia de los reguladores de crecimiento para la obtención de callos friables en caucho (Hevea brasiliensis Müll. Arg. sin llegar a obtenerse regeneración de plántulas. En todos los ensayos realizados en este estudio, se utilizaron dos clones de diferentes orígenes geográficos: el FX 3864 (suramericano y el PB 254 (asiático. Para los diferentes tratamientos se utilizaron como explantes hojas j

  16. Ontogenia e estrutura do pericarpo de Prestonia riedelii (Müll. Arg. Markgr. (Apocynaceae Pericarp ontogeny and structure of Prestonia riedelii (Müll. Arg. Markgr. (Apocynaceae

    Directory of Open Access Journals (Sweden)

    Shesterson Aguiar

    2009-09-01

    Full Text Available O trabalho teve por objetivos descrever a ontogenia e estrutura do pericarpo de P. riedelii, visando fornecer subsídios aos trabalhos taxonômicos, filogenéticos e ecológicos realizados para família. Flores e frutos em diferentes estádios de desenvolvimento foram fixados em FAA, incluídos em resina plástica, seccionados com 10 ìm e corados com azul de toluidina para análise estrutural. O fruto de P. riedelii é um folicarium, sendo formado por dois frutículos do tipo folículo. O epicarpo, originado da epiderme externa do ovário, é formado por uma camada de células epidérmicas de cutícula espessa e tricomas tectores multicelulares e unisseriados. O mesocarpo, originado a partir do desenvolvimento do tecido fundamental, é formado por várias camadas de células parenquimáticas, feixes vasculares, fibras não lignificadas e laticíferos. O endocarpo sensu lato é formado por duas camadas de esclerócitos de disposição cruzada, que se originam da epiderme interna do ovário e de uma camada de células do tecido fundamental. A deiscência de cada folículo é marginal e o processo de deiscência envolve um conjunto de características anatômicas, como células de parede delgada e sinuosa formando a linha de deiscência, fibras não lignificadas no mesocarpo e esclerócitos de disposição cruzada no endocarpo.The aim of this work was to describe the morphology and ontogeny of P. riedelii fruits to aid in taxonomic, ecological and phylogenetic studies in Apocynaceae. Fruits were fixed in FAA, embedded in plastic resin, sectioned at 10 ìm and stained with toluidine blue, for structural analysis. The fruit of P. riedelii is a follicarium, with two follicular fruitlets. The epicarp is one-cell-layered, with trichomes and thick cuticle. The mesocarp, originating from fundamental ovary tissue, is parenchymatous with laticifers, non-lignified fibers and vascular bundles. The endocarp sensu lato is two-celllayered of crossed sclereids, originating from the inner ovary epidermis and from a single layer of parenchyma cells of fundamental ovary tissue. Follicle dehiscence is lateral and the dehiscence process involves anatomical characteristics such as a dehiscence zone with thin-walled cells, non-lignified fibers in the mesocarp and crossed sclereids in the endocarp.

  17. Bypassing the Limits of Ll Regularization: Convex Sparse Signal Processing Using Non-Convex Regularization

    Science.gov (United States)

    Parekh, Ankit

    Sparsity has become the basis of some important signal processing methods over the last ten years. Many signal processing problems (e.g., denoising, deconvolution, non-linear component analysis) can be expressed as inverse problems. Sparsity is invoked through the formulation of an inverse problem with suitably designed regularization terms. The regularization terms alone encode sparsity into the problem formulation. Often, the ℓ1 norm is used to induce sparsity, so much so that ℓ1 regularization is considered to be `modern least-squares'. The use of ℓ1 norm, as a sparsity-inducing regularizer, leads to a convex optimization problem, which has several benefits: the absence of extraneous local minima, well developed theory of globally convergent algorithms, even for large-scale problems. Convex regularization via the ℓ1 norm, however, tends to under-estimate the non-zero values of sparse signals. In order to estimate the non-zero values more accurately, non-convex regularization is often favored over convex regularization. However, non-convex regularization generally leads to non-convex optimization, which suffers from numerous issues: convergence may be guaranteed to only a stationary point, problem specific parameters may be difficult to set, and the solution is sensitive to the initialization of the algorithm. The first part of this thesis is aimed toward combining the benefits of non-convex regularization and convex optimization to estimate sparse signals more effectively. To this end, we propose to use parameterized non-convex regularizers with designated non-convexity and provide a range for the non-convex parameter so as to ensure that the objective function is strictly convex. By ensuring convexity of the objective function (sum of data-fidelity and non-convex regularizer), we can make use of a wide variety of convex optimization algorithms to obtain the unique global minimum reliably. The second part of this thesis proposes a non-linear signal decomposition technique for an important biomedical signal processing problem: the detection of sleep spindles and K-complexes in human sleep electroencephalography (EEG). We propose a non-linear model for the EEG consisting of three components: (1) a transient (sparse piecewise constant) component, (2) a low-frequency component, and (3) an oscillatory component. The oscillatory component admits a sparse time-frequency representation. Using a convex objective function, we propose a fast non-linear optimization algorithm to estimate the three components in the proposed signal model. The low-frequency and oscillatory components are then used to estimate the K-complexes and sleep spindles respectively. The proposed detection method is shown to outperform several state-of-the-art automated sleep spindles detection methods.

  18. Préparation et caracterisation de composites ll verre-supraconducteur gg

    Science.gov (United States)

    Roblin-Semène, L.; Pradel, A.; Ribes, M.; Belouet, C.

    1994-11-01

    Several types of " glass/superconductor " composites were prepared by a uniaxial hot pressing method. The BiSrCaCuO oxides were the materials under investigation in this work. A preliminary study of glasses obtained in this BiSrCaCuO system indicated that phase separation with nodules of 50 to 100 nm generally occurs. Glasses used as parts of composites are : 1) PbOB2O3 ones because of their low transition temperature and their large thermal stability which were favourable to texturation of superconducting grains, 2) BiSrCaCuO (2212, 2223, 4334) glasses because further recrystallisation could be carried out to improve grain connectivity and at last 3) mixture of BiSrCaCuO glass and V2O5 or PbO-B2O3 to insure a compromise between texturing and connectivity. Resistivity and current density measurements indicated that these types of composites were potential candidates for use as current limiters. Différents composites " verre/supraconducteur " ont été préparés par pressage à chaud uniaxial. Nos travaux ont porté sur les oxydes " BiSrCaCuO ". Une étude préalable des verres de ce système a permis de mettre en évidence une séparation de phase avec présence de nodules dont la taille est comprise entre 50 et 100 nm. Les verres choisis pour l'élaboration de ces composites ont été : 1 ) le verre PbO-B2O3 dont la basse température de transition vitreuse et la grande stabilité thermique étaient des éléments favorables à une bonne texturation des grains supraconducteurs, 2) les verres BiSrCaCuO purs (2212, 2223, 4334) dont la recristallisation partielle par recuit a posteriori devait assurer une meilleure connectivité entre grains, et enfin 3) des mélanges " BiSrCaCuO (V) " + V2O5 OU PbO-B2O3 qui devaient permettre d'assurer un compromis entre texturation et connectivité. Les mesures de résistivité et de densité de courant montrent que ces composites sont de bons candidats pour des applications de limiteur de courant.

  19. "Berlinale 2008" - küll jahe, aga lahe! / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2008-01-01

    Berliini 58. filmifestivali auhinnasaajatest : Kuldkaru võitis Brasiilia produtsendi ja režissööri Jose Padilha mängufilm "Eliitrühm", Hõbekaru USA režissööri Errol Morrise dokfilm "Tavaprotseduur". Parima režissööri Hõbekaru läks Paul Thomas Andersonile mängufilmi "Veri hakkab voolama" eest. Parima näitleja auhinna said Sally Hawkins ja Reza Naji, Alfred Baueri auhinna sai Fernando Eimbcke "Tahoe järv"

  20. B→K1l+l- decays in a family non-universal Z' model

    International Nuclear Information System (INIS)

    Li, Ying; Hua, Juan; Yang, Kwei-Chou

    2011-01-01

    The implications of the family non-universal Z' model in the B→K 1 (1270,1400)l + l - (l=e,μ,τ) decays are explored, where the mass eigenstates K 1 (1270, 1400) are the mixtures of 1 P 1 and 3 P 1 states with the mixing angle θ. In this work, considering the Z' boson and setting the mixing angle θ=(-34±13) , we analyze the branching ratio, the dilepton invariant mass spectrum, the normalized forward-backward asymmetry and lepton polarization asymmetries of each decay mode. We find that all observables of B→K 1 (1270)μ + μ - are sensitive to the Z' contribution. Moreover, the observables of B→K 1 (1400)μ + μ - have a relatively strong θ-dependence; thus, the Z' contribution will be buried by the uncertainty of the mixing angle θ. Furthermore, the zero crossing position in the FBA spectrum of B→K 1 (1270)μ + μ - at low dilepton mass will move to the positive direction with Z' contribution. For the tau modes, the effects of Z' are not remarkable due to the small phase space. These results could be tested in the running LHC-b experiment and super-B factory. (orig.)

  1. Exercising choice for national healthcare. In the end, we'll get what we choose.

    Science.gov (United States)

    Bruder, P

    1992-01-01

    Whether we evolve toward a market model, a play-or-pay model, or a national model will depend largely upon our personal beliefs and perspectives. Unfortunately, in the hectic and fast-paced life that virtually all of us lead, we base many of our conclusions on unexamined bits and pieces of conventional wisdom. We have looked at but five of them. Yet these bits and pieces become the yardsticks by which we measure other plans and other people. Instead of listening to and studying the approaches proposed by others, we are often too quick to dismiss them with labels such as "too costly," or "too capitalist," or "too socialist," or "too whatever." As a consequence, we become prisoners of our own ideology. Would that we were more like Tillich's (1951) description of the famous theologian, Karl Barth, who "...strenuously tries not to become his own follower" (5). In other words, we would work to continually inform and correct ourselves in light of new understanding. Our healthcare problems--any social problems, for that matter--are never really solved. All we can do is do our best at meeting needs, even if it means that in meeting one set of needs we inadvertently create other needs. But that is why we are enriched when we accept the challenge of continuing to question our personal bits and pieces of conventional wisdom. In a recent column in the Houston Post, Richard Reeves cites statistical evidence, known to most who work in the healing professions, indicating that people who live alone tend to suffer from greater illness.(ABSTRACT TRUNCATED AT 250 WORDS)

  2. "I'll Always Remember Your Class." Powerful Encouragement through Personal Notes.

    Science.gov (United States)

    Chiodo, Beverly A.

    1994-01-01

    A business teacher teachers students to write letters of praise and appreciation to develop leadership skills, strengthen relationships, and envision personal and professional success for their peers. (SK)

  3. Targeting MED1 LxxLL Motifs for Tissue-Selective Treatment of Human Breast Cancer

    Science.gov (United States)

    2012-09-01

    Tuerk and Gold, 1990). These RNA molecules were termed as “aptamers,” with etymology stemming from the Greek word aptus, which means “to fit...molecular imaging. Analytical and Bioanalytical Chemistry 399, 1591-1599. Thiel, K.W., and Giangrande, P.H. (2010). Intracellular delivery of RNA-based

  4. Doktoriväitekiri terminoloogia ja tõlkimise teemal / Peeter Päll

    Index Scriptorium Estoniae

    Päll, Peeter, 1961-

    2009-01-01

    Arvustus: Tavast, Arvi. The translator is human too: a case for instrumentalism in multilingual specialised communication. Tartu : Tartu University Press, c2008. (Dissertationes philologiae estonicae Universitatis Tartuensis ; 21)

  5. Tests were inconclusive: California's experiment with ACOs raises questions about whether they'll save money.

    Science.gov (United States)

    Vesely, Rebecca

    2010-11-01

    In California, many providers have been working in accountable care organizations for decades, and they say they can work well. "It's not the type of organization that defines the success of an ACO, it's the leadership," said Tom Williams, executive director of the Oakland, Calif.-based Integrated Healthcare Association. "For success, there needs to be alignment between hospitals and physicians."

  6. We'll Make You a Better Teacher: Learning from Guitar Techniques

    Science.gov (United States)

    Greenbowe, Thomas J.

    2008-02-01

    It is worth noting that there are more resources and more uses of technology available world-wide to help individuals become better guitar players than there are resources available to help individuals become better science teachers. Providing resources and services to help individuals become effective chemistry teachers and improve their chemistry teaching and expand their range of techniques is a worthwhile endeavor. This commentary proposes that a new magazine should be developed and designed to complement and augment the Journal of Chemical Education , the Examinations Institute, the BCCEs, and programming at regional, national, and international meetings. We need to be making use of the expertise of chemical educators from around the world to convey the best practices of teaching chemistry. This magazine would feature topics directly relating to teaching chemistry in the classroom and it would include master teachers explaining and discussing chemistry education techniques. A Web site and perhaps a DVD would have digital movies of master chemistry teachers illustrating how they implement a specific technique with students. The Web site would serve as a repository for resources. It would serve as an alternative site for professional development.

  7. Andrzej Wajda : maailm küll teadis, aga ei hoolinud / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    Poola filmi- ja teatrilavastaja Andrzej Wajda, kes pälvis sel aastal president Toomas Hendrik Ilveselt Maarjamaa Risti III klassi teenetemärgi. Tema viimasest mängufilmist "Katõn". Lisatud andmed elu ja töö kohta. Ordenit vastu võtma A. Wajda ei tule, sest 24. veebruaril 2008 läheb ta Los Angeleses Oscarite galale, kus tema film "Katõn" on parima võõrkeelse filmi auhinna nominent

  8. 'Come and live here and you'll experience it': : Youths talk about their deprived neighbourhood

    NARCIS (Netherlands)

    Visser, Kirsten; Bolt, Gideon; van Kempen, Ronald

    2015-01-01

    This study examined youths' lived experiences of a deprived neighbourhood in Rotterdam, the Netherlands. Previous studies assume that deprived neighbourhoods pose serious risks for youths. What is largely missing from these studies, however, are the experiences of young people themselves. Do they

  9. I'll Have What She's Having: The Impact of Model Characteristics on Children's Food Choices

    Science.gov (United States)

    Frazier, Brandy N.; Gelman, Susan A.; Kaciroti, Niko; Russell, Joshua W.; Lumeng, Julie C.

    2012-01-01

    This research investigates children's use of social categories in their food selection. Across three studies, we presented preschoolers with sets of photographs that contrasted food-eating models with different characteristics, including model gender, race (Black, White), age (child or adult), and/or expression (acceptance or rejection of the…

  10. "But-He'll Fall!": Children with Autism, Interspecies Intersubjectivity, and the Problem of 'Being Social'.

    Science.gov (United States)

    Solomon, Olga

    2015-06-01

    'Being autistic' or 'having Autism Spectrum Disorder' implies a limited range of 'being social,' but the in situ organization of interaction, what Maynard and Marlaire (Qual Soc 15(2):177-202, 1992) call the 'interactional substrate,' within which this delimitation enfolds is usually hidden from sight. Analysis of processes constituting different 'interactional substrates' provides a view of how one comes to be known by and to self and others as a certain kind of being who is available (or not) for acting and feeling in certain ways. People diagnosed with Autism Spectrum Disorder (American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 2013) are often described as 'being' impaired in intersubjective understanding of others. But the story of ASD as an impairment of sociality and intersubjectivity becomes more complicated when animals enter into the picture. I consider two interactional substrates: a psychological interview in a mental health clinic, and an animal-assisted activity in a child's neighborhood. I aim to elucidate the practical problems of 'being social' encountered by two children with ASD, both nine-year-old girls, within these two very differently organized interactional substrates. I consider ways in which 'being with' therapy animals provides a way of 'being social' through "sensory modalities of knowing" (Haraway, When species meet, 2008:371).

  11. Febre amarela ll - Estudo histopatológico do fígado

    Directory of Open Access Journals (Sweden)

    Leon Cardeman

    1976-04-01

    Full Text Available Ao curso de um surto epizoótico de febre amarela acontecido no ano de 1973 nas regiões norte e centro-oeste do Brasil, foram feitos exames histopatológicos de material de fígado de casos suspeitos, retirados por viscerotomia e necropsias. Foram diagnosticados 57 casos positivos. Os exames histopatológicos demonstraram que não existe diferença da doença entre os casos da África e da América do Sul. O diagnóstico histopatológico continua baseado no fígado, na lesão de Councilman, na hiperplasia e hipertrofia das células de Kupfer, nas inclusões nucleares de Magarino Torres, no sinal de Eudoro Villela nos casos de longa duração. Não houve diferença histológica entre os casos descritos nas epidemias de F.A. urbana e os surtos epidêmicos e enzoóticos de F.A. silvestre nos últimos 43 anos.

  12. Moskva juubelifestival 200 filmiga - mida küll valida? / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    2008-01-01

    19.-30. juunini toimuvast XXX Moskva rahvusvahelisest filmifestivalist. Festivaliprogrammi direktor on Kirsi Tykkyläinen, žürii esimees Liv Ullmann. Võistluskavast, kus eesti filmi pole. Eriprogrammis "8 1/2 filmi" on Veiko Õunpuu "Sügisball". Ka festivali ajaloost

  13. I’ll Show You the Way: Risky Driver Behavior When “Following a Friend”

    Directory of Open Access Journals (Sweden)

    Jaimie McNabb

    2017-05-01

    Full Text Available Previous research examining social influences on driving behavior has primarily focused on the effects of passengers and surrounding vehicles (e.g., speed contagion. Of current interest was the interaction between drivers that occurs in a “following a friend” scenario, i.e., the driver of one vehicle (the leader knows how to get to the desired destination while the driver of a second vehicle (the follower does not. Sixteen participants drove through a simulated city in a driving simulator under three conditions: (i a baseline condition in which they could choose their own route, (ii a navigation system condition in which they were given audible route instructions, and (iii a “follow a friend” condition in which they required to follow a simulated vehicle. In the follow a friend condition, drivers engaged in significantly more risky behaviors (in comparison to the other conditions such as making more erratic and higher speed turns and lane changes, maintaining overall higher speed, as well as maintaining a shorter time headway when following a lead vehicle. These effects suggest a relationship to time pressure caused by a fear of getting lost.

  14. Progress Report on FY15 Crystalline Experiments M4FT-15LL0807052

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Zhao, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Joseph, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Begg, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dai, Z. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kersting, A. B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-13

    Colloid-facilitated plutonium transport is expected to be the dominant mechanism in its migration through the environment. The forms of Pu colloids (intrinsic versus pseudo-colloid) and their stabilities control temporal and spatial scales of Pu transport in the environment. In the present study, we examine the stability of Pu intrinsic colloids freshly prepared in alkaline solution relative to Pu-montmorillonite pseudo-colloids using a dialysis device and modeling approaches. Intrinsic colloids prepared under alkaline conditions were found to be unstable over a timescale of months. The kinetics of multiple processes, including hydrolysis/precipitation of Pu(IV), dissolution of intrinsic colloids in the absence and presence of the clay colloids, transport of dissolved Pu species across the dialysis membrane, and formation of pseudo-colloids were examined. The dissolution of intrinsic colloids was the rate-limiting process in most cases. The apparent intrinsic colloid dissolution rate constants range from 6×10-7 to 1×10- 6 mol·m-2·day-1 and 4×10-6 to 8×10-6 mol·m-2·day-1 at 25 and 80°C, respectively, while the apparent diffusion rate constants for Pu ions crossing the dialysis membrane are >200 times higher. Elevated temperatures enhance dissolution of Pu colloids and the activation energy for the process is estimated to be 28 kJ mol-1. The sorption of Pu to montmorillonite appears to be endothermic as the affinity of Pu for the clay increases with increasing temperature. Our results provide an in-depth understanding of how intrinsic and pseudo-colloids interact with each other kinetically. Although the fact that intrinsic colloids tend to dissolve in the presence of montmorillonite and transform into pseudo-colloids may limit the migration of intrinsic colloids, the thermodynamically more stable pseudo-colloids may play an important role in Pu transport in the environment over significant temporal and spatial scales.

  15. Influence of Terrestrial Weathering on the Magnetic Record of a LL Chondrite

    Science.gov (United States)

    Kohout, T.; Kletetschka, G.; Wasilewski, P.

    2001-12-01

    The origin of our solar system may have been accompanied by transient energetic events capable of magnetizing the materials from which the solid bodies in the solar system formed. The magnetic field associated with some of some of these events should have been recorded by the magnetic mineralogy contained within meteorites. To extract this information from meteorites many noise components must be carefully eliminated. The fusion crust has long been established as restricted to a thin layer on the surface of meteorite. Magnetic screening of the fusion crust that relates to Murchison meteorite indicates that during the entry and landing at least 6 mm thick layer is affected by terrestrial TRM acquisition. Many of the meteorite finds have long term residence in the terrestrial oxidized environment. This weathering is the subject of this study. The meteorite in question landed in the Libya stony desert and has obvious surface weathering that can be referred to as desert varnish. The consequent iron oxide mineralization introduced very stable origin of very stable chemical remanent magnetization. The magnetic remanence in fragments without the desert varnish is between 20 - 50 % of the oxidized ones. The orientation of this CRM appears to be random indicating that the sample may have rotated during the long period of aeolian transport and varnish formation. Magnetization of the white matrix samples (20 - 50 % of weathered ones) is thermally more stable and also randomly oriented. The range of NRM/SIRM values for both mineralogies varies between 10-2 and 10-3. Acknowledgements: This work would not be possible without help of following people: Jakub Haloda, Petr Jakes, Marcela Bukovanska, Petr Pruner, Vladimir Kohout, Libuse Kohoutova, Vladimir Kohout, Olga Kohoutova.

  16. We'll stay in touch: Intuitive communication means for social connectedness

    NARCIS (Netherlands)

    Biemans, Margaretha Catharina Maria; van Halteren, Aart; van Dijk, Elisabeth M.A.G.; Rijckenberg, Gert-Jan; van Pelt, Xander; Poortinga, Remco

    One of the dominant aspects in people’s well-being is social connectedness. Social connectedness refers to the subjective awareness of being in close interpersonal, meaningful, and positive social relationships and social contexts (Tilburg et al., 1998; Perlman & Paplau 1981). In our research

  17. Hamid Karzai on küll Afganistani riigipea, aga Massoud on kangelane / Leslie Leino

    Index Scriptorium Estoniae

    Leino, Leslie

    2005-01-01

    Afganistani valimistel võitsid opositsionäärid, tugevaim figuur nende hulgas on Ahmad Shah Massoudi kunagine kaasvõitleja Yunus Qanun, kelle siht on võõrväed riigist välja viia ja riik ühendada. Ameeriklased ja nende liitlased on ärevil, sest Qanun pole võõrvägede hulgas populaarne. Lisa: Põhimõtteliselt ameeriklaste vastu. Vt. samas: Afganistanis alustas pärast 30-aastast pausi tööd parlament

  18. Benchmarking of the simulation of the ATLAS HaLL background

    International Nuclear Information System (INIS)

    Vincke, H.

    2000-01-01

    The LHC, mainly to be used as a proton-proton collider, providing collisions at energies of 14 TeV, will be operational in the year 2005. ATLAS, one of the LHC experiments, will provide high accuracy measurements concerning these p-p collisions. In these collisions also a high particle background is produced. This background was already calculated with the Monte Carlo simulation program FLUKA. Unfortunately, the prediction concerning this background rate is only understood within an uncertainty level of five. The main contribution of this factor can be seen as limited knowledge concerning the ability of FLUKA to simulate these kinds of scenarios. In order to reduce the uncertainty, benchmarking simulations of experiments similar to the ATLAS background situation were performed. The comparison of the simulations with the experiments proves to which extent FLUKA is able to provide reliable results concerning the ATLAS background situation. In order to perform this benchmark, an iron construction was irradiated by a hadron beam. The primary particles had ATLAS equivalent energies. Behind the iron structure, the remnants of the shower processes are measured and simulated. The simulation procedure and its encouraging results, including the comparison with the measured numbers, are presented and discussed in this work. (author)

  19. Te hablaré con mis caricias I´ll talk to you with my caresses

    Directory of Open Access Journals (Sweden)

    Carmen Nieto Molina

    2010-06-01

    Full Text Available Este relato describe una escena cotidiana entre una enfermera y una paciente en una residencia. Se pretende reflejar la relación que se mantiene entre enfermera-paciente y la actuación enfermera desde una perspectiva más amplia y holística. Una relación significativa y beneficiosa para ambas, la enfermera y la paciente. La descripción se basa en una observación, en la valoración de las necesidades de la persona y la incorporación de la historia de la vida como análisis del material terapéutico. De dicho análisis podemos comprobar la eficacia de una atención y cuidado enfermero individualizados, empáticos, que reconoce a la persona que padece demencia como un todo durante su proceso de cuidados y final de vida.This story describes an everyday scene between a nurse and a patient in a nursing home. It is intended to reflect the relationship stands between nurse-patient and nurse performance in a more comprehensive and holistic. A significant and beneficial for both the nurse and patient. The description is based on an observation in assessing the needs of the person and the incorporation of life history and analysis of therapeutic material. From this analysis we can test the effectiveness of an individualized care and nursing care, empathetic, which recognizes the person with dementia as a whole during the process of care and end of life.

  20. We'll meet again: revealing distributional and temporal patterns of social contact.

    Directory of Open Access Journals (Sweden)

    Thorsten Pachur

    Full Text Available What are the dynamics and regularities underlying social contact, and how can contact with the people in one's social network be predicted? In order to characterize distributional and temporal patterns underlying contact probability, we asked 40 participants to keep a diary of their social contacts for 100 consecutive days. Using a memory framework previously used to study environmental regularities, we predicted that the probability of future contact would follow in systematic ways from the frequency, recency, and spacing of previous contact. The distribution of contact probability across the members of a person's social network was highly skewed, following an exponential function. As predicted, it emerged that future contact scaled linearly with frequency of past contact, proportionally to a power function with recency of past contact, and differentially according to the spacing of past contact. These relations emerged across different contact media and irrespective of whether the participant initiated or received contact. We discuss how the identification of these regularities might inspire more realistic analyses of behavior in social networks (e.g., attitude formation, cooperation.

  1. "I'll have one of each": how separating rewards into (meaningless) categories increases motivation.

    Science.gov (United States)

    Wiltermuth, Scott S; Gino, Francesca

    2013-01-01

    We propose that separating rewards into categories can increase motivation, even when those categories are meaningless. Across six experiments, people were more motivated to obtain one reward from one category and another reward from another category than they were to obtain two rewards from a pool that included all items from either reward category. As a result, they worked longer when potential rewards for their work were separated into meaningless categories. This categorization effect persisted regardless of whether the rewards were presented using a gain or loss frame. Using both moderation and mediation analyses, we found that categorizing rewards had these positive effects on motivation by increasing the degree to which people felt they would "miss out" if they did not obtain the second reward. We discuss implications for research on motivation and incentives.

  2. "I'll Remember This!" Effects of Emotionality on Memory Predictions versus Memory Performance

    Science.gov (United States)

    Zimmerman, Carissa A.; Kelley, Colleen M.

    2010-01-01

    Emotionality is a key component of subjective experience that influences memory. We tested how the emotionality of words affects memory monitoring, specifically, judgments of learning, in both cued recall and free recall paradigms. In both tasks, people predicted that positive and negative emotional words would be recalled better than neutral…

  3. Targeting MED1 LxxLL Motifs for Tissue-Selective Treatment of Human Breast Cancer

    Science.gov (United States)

    2014-09-01

    microRNA, antisense oligonucleotides, and RNA aptamers, has long been extensively studied (Guo 2010; Keefe et al. 2010; Levy-Nissenbaum et al. 2008; Que...targeted drug delivery when compared with DNA aptamers, protein aptamers, and antibodies (Guo 2010; Keefe et al. 2010; Que-Gewirth and Sullenger...or even organisms (Dua et al. 2011; Keefe et al. 2010; Levy-Nissenbaum et al. 2008; Thiel and Giangrande 2010). Those that do not bind to the target

  4. Things I'll Never Say: Stories of Growing up Undocumented in the United States

    Science.gov (United States)

    Hernandez, Ingrid; Mendoza, Fermin; Lio, Mario; Latthi, Jirayut; Eusebio, Catherine

    2011-01-01

    Debate goes on about the proposed Development, Relief and Education for Alien Minors (DREAM) Act. In presidential speeches, one-minute congressional floor statements, and intermittent media coverage, we hear passionate arguments for and against this federal legislation that would provide a path toward citizenship for hundreds of thousands of…

  5. TRENDS IN MONTHLY R INF LL ND TEMPER TURE IN R ...

    African Journals Online (AJOL)

    USER

    2016-11-05

    Nov 5, 2016 ... Ethiopian Journal of Environmental Studies & Management 9(6): 738 – 747, 2016. ... Department of Mathematics, Kibabii University, Kenya ... (1985-2014) data trends over Rachuonyo North Sub County at 50 50 ... December.

  6. Tell Me Your Ads and I'll Tell You Who You Are

    OpenAIRE

    Olteanu, Alexandra-Mihaela

    2012-01-01

    Google AdSense, one of the most popular Online Advertise Networks, uses a mix of two techniques to deliver ads: contextual ads and behavioral ads, but it is not clear when or how much of the both they actually use. In this work, we raise several concerns regarding behavioral ads. End-users have very little control: once behavioral ads are allowed (which is the default setting), it is hard to predict what part about a user's past interests they will reveal. Our goal in this work is to understa...

  7. August välja küll, aga kunas ja kuidas? / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2009-01-01

    USA majandustsüklite uurija Victor Zarnowitz väidab, et järsule majanduslangusele järgneb kiire tõus. Autor leiab, et Eestit võimaldavad majanduskriisist välja tuua mitte ainult õiged otsused valitsussektoris, vaid ka erasektoris

  8. Sweat the Small Stuff and You'll Come out Ahead: Marketing That Makes a Difference.

    Science.gov (United States)

    Golden, Sandra

    1991-01-01

    Argues that effective marketing is essential for community colleges to keep pace with a changing environment. Presents a broad definition of marketing that includes delivery of educational services and maintenance of a student-centered college environment. Reviews award-winning two-year college marketing strategies and outlines a step-by-step…

  9. Portreefotograafia Oscarid. Kuidas neid küll jagada? / Annika Haas ; kommenteerinud Birgit Püve

    Index Scriptorium Estoniae

    Haas, Annika, 1974-

    2016-01-01

    Londoni rahvusliku portreegalerii (National Portrait Gallery) poolt 2003. aastal algatatud portreefotokonkursist Taylor Wessing Photographic Portrait Prize (TWPPP). 2015. aasta võidutöö: David Stewart "Viis tüdrukut"

  10. Febre amarela ll - Estudo histopatológico do fígado

    Directory of Open Access Journals (Sweden)

    Leon Cardeman

    1976-04-01

    Full Text Available Ao curso de um surto epizoótico de febre amarela acontecido no ano de 1973 nas regiões norte e centro-oeste do Brasil, foram feitos exames histopatológicos de material de fígado de casos suspeitos, retirados por viscerotomia e necropsias. Foram diagnosticados 57 casos positivos. Os exames histopatológicos demonstraram que não existe diferença da doença entre os casos da África e da América do Sul. O diagnóstico histopatológico continua baseado no fígado, na lesão de Councilman, na hiperplasia e hipertrofia das células de Kupfer, nas inclusões nucleares de Magarino Torres, no sinal de Eudoro Villela nos casos de longa duração. Não houve diferença histológica entre os casos descritos nas epidemias de F.A. urbana e os surtos epidêmicos e enzoóticos de F.A. silvestre nos últimos 43 anos.During an epizootic outbreak of yellow fever ocurred in the year of 1973 in the north and middte west regions of Brazil, histopatological slides of liver material were made from suspected cases removed by viscerotomy and necropsies. There where diagnosed 57 positive cases. The histopatological slides demonstrated that there are no differences between the cases of the disease in Africa and South America. The histopatological diagnosis goes on based on the Hver, in the Councilman lesion, in hyperplasia and hypertrophy of the Kupfer cells, in delayed cases. There was no histological difference between the cases described in urban yellow fever epidemics and epidemic andenzootic outbreaks of jungle yellow fever in the last 43 years.

  11. Write It So They'll Read It: Popular Annual Financial Reporting.

    Science.gov (United States)

    Anderson, Richard T.; Piotrowski, Craig L.

    1994-01-01

    Waukesha County Technical College (Wisconsin) received the Governmental Financial Officers Association "Popular Annual Financial Reporting Award" in 1993 and became the first educational entity to do so. Popular annual financial reporting is an effective way for schools to present reader-friendly reports that stress graphics and…

  12. Lincoln Laboratory Evaluation of TCAS II Logic Version 6.O4a - Appendices. Volume ll.

    Science.gov (United States)

    1996-02-15

    M to to r«. r«, o oo oo OOOCMIMOOrOtOCSOOCMCMOIMCM • •-• ••••••••••■«« g <>NN *-»-oo oo N.r«.«~ CM CM rococo OOKh-CMCMɘ>OIMCM«»trtm«»?i™ tO to...oo«o«o«oo h- rococo co<o m CM CM CM CM CM «O CM 00 00 ooo «»roro to to CM r«-«-vo to OCMO «» «»m«- ororo CM CM OO OO eo co to ro...o »-»» OsOSNKKin****«*0> rococo T-OCMCM COvOO-h- >OMOm rgrJfiri’if;f;r^NŔs’ot>’oorv,,0000t>>McocM>ocoooM<ocM<oo «-«->0𔃺>0^>0>0>0(OinMM𔃺-0

  13. "I'll Speak in Proper Slang": Language Ideologies in a Daily Editing Activity

    Science.gov (United States)

    Godley, Amanda J.; Carpenter, Brian D.; Werner, Cynthia A.

    2007-01-01

    The purpose of this study was to examine the language ideologies--the assumptions about the nature of language, language variation, and language learning--reflected in a widespread daily editing activity often known as Daily Oral Language or Daily Language Practice. Through a yearlong ethnographic study of grammar instruction in three urban,…

  14. I’ll Never Forgive You: High Conflict Divorce, Social Network, and Co-Parenting Conflicts

    NARCIS (Netherlands)

    Visser, M.M.; Finkenauer, Catrin; Schoemaker, Kim S.; Kluwer, Esther S.; van der Rijken, Rachel; van Lawick, Justine; Bom, Hans; de Schipper, J. Clasien; Lamers, F.

    2017-01-01

    The relation between divorce, co-parenting conflicts, and children’s adjustment problems has been well established. An unresolved question for research and clinical interventions, however, is how conflicts between parents are maintained and/or escalate. This cross-sectional research tested the

  15. I'll never forgive you: High conflict divorce, social network, and co-parenting conflicts

    NARCIS (Netherlands)

    Visser, M.; Finkenauer, C.; Schoemaker, K.; Kluwer, E.S.; Rijken, R.E.A. van der; Lawick, M.J. van; Bom, H.; Schipper, J.C. de; Lamers, F.

    2017-01-01

    The relation between divorce, co-parenting conflicts, and children's adjustment problems has been well established. An unresolved question for research and clinical interventions, however, is how conflicts between parents are maintained and/or escalate. This cross-sectional research tested the

  16. Ensayo piloto de biorremediación de suelos contaminados por hidrocarburos. Fase ll

    Directory of Open Access Journals (Sweden)

    Gloria Lucía Camargo Millán

    2009-06-01

    Full Text Available  El estudio de la biodegradación de los hidrocarburos compuestos,altamente contaminantes y tóxicos, es de interéspara la descontaminación de ambientes afectados por derramesde petróleo. Aunque este proceso se presenta demanera natural, es demasiado lento, razón por la que sehace necesario el uso de técnicas de biorremediación parafacilitar la acción microbiana sobre los contaminantes. Anivel experimental este proceso se realiza por etapas o ensayos,ya sean de laboratorio, pilotos, de campo oimplementación. Previamente a este estudio se trabajó unaetapa a nivel de laboratorio, donde se observó la remociónde hidrocarburo en un suelo contaminado de manera inducida,aislándose bacterias capaces de su degradación, loque mostró que el proceso es factible. El presente estudiocorresponde a la etapa a nivel piloto, cuyo objetivo eracuantificar la tasa de remoción de hidrocarburo en muestrasde suelo contaminadas con crudo de castilla provenientede diez terrarios, a los cuales se les inoculó bacteriastotales y bacterias Pseudomonas aeruginosa.

  17. CLAM - CoLlAborative eMbedded networks for submarine surveillance: An overview

    NARCIS (Netherlands)

    Meratnia, Nirvana; Havinga, Paul J.M.; Casari, Paolo; Petrioli, Chiara; Grythe, Knut; Husoy, Thor; Zorzi, Michele

    2011-01-01

    This paper provides an overview of the CLAM project, which aims at developing a collaborative embedded monitoring and control platform for submarine surveillance by combining cutting edge acoustic vector sensor technology and 1D, 2D, 3D sensor arrays, underwater wireless sensor networks protocol

  18. There'll Always Be an England: Anglophilia as Antimodern Leisure

    Science.gov (United States)

    Plato, Michael

    2010-01-01

    North Americans have had a lengthy and often one-sided relationship with Great Britain. Long after the waning of the British Empire and the apex of Britain's exercise of global political and economic hegemony, its cultural influence remains strong. Beyond the commercial successes in the box office and the bookstore, there is a much more immersive,…

  19. Commentary: "I hope i'll continue to grow": rubrics and reflective writing in medical education.

    Science.gov (United States)

    Coulehan, Jack; Granek, Iris A

    2012-01-01

    One respected tradition in medical education holds that physicians should struggle to maintain sensibility, openness, and compassion in the face of strong contravening tendencies. However, today's medical education is structured around a more recent tradition, which maintains that physicians should struggle to develop emotional detachment as a prerequisite for objectivity. In this model, sensibility and reflective capacity are potentially subversive. Reflective writing is one component of a revisionist approach to medical education that explicitly addresses reflective "habits of the mind" as core competencies and builds on existential concerns voiced by medical students. In response to Wald and colleagues' study, the authors reflect on the role of repeated formative feedback in developing reflective capacity. Formative feedback is as critical in this process as it is in traditional clinical learning. The authors emphasize that well-designed rubrics can assist learners in delineating desired outcomes and teachers in providing appropriate guidance.

  20. Abilinnapea Jaanson : kasvuruumi on küll / Karin Jaanson ; interv. Martin Shmutov

    Index Scriptorium Estoniae

    Jaanson, Karin

    2006-01-01

    Rahanduse eest vastutav Tartu abilinnapea vastab intervjuus 2006. aasta Tartu eelarvet puudutavatele küsimustele. Diagramm, tabel: Tartu linn kulutab tuleval aastal 1 360 535 800 krooni, investeeringud

  1. Eesti maalikunsti väljasuremist pole küll karta...

    Index Scriptorium Estoniae

    1999-01-01

    Eesti Maalikunstnike Liidu näitused. 17. juunil seinamaali konkurss Tallinna Kunstihoone hoovis. 18. juunist Kursi koolkonna uudislooming Raatuse galeriis, Eha Komissarovi kureeritud "Maal'99" Tallinna Kunstihoones, Ants Juske projekt "Uus ja vana narratsioon", mis ühendab maalilisuse, figuratiivsuse ja jutustuse eri kunstiliikides, Rotermanni soolalaos. Avamisel trio "Fragile" happening

  2. Beyond Counseling and Psychotherapy, There Is a Field. I'll Meet You There

    Science.gov (United States)

    Timm-Bottos, Janis

    2016-01-01

    Beyond a counseling or psychotherapy practice, the future of art therapy demands a new type of creativity, solidarity, and social inclusion. This viewpoint explores the art therapy profession and the role of educational practices to envision change in uncertain times. Art therapists have the ability to offer expertise in the serious dilemmas…

  3. Oh the Places You'll Go, with Graphene: A Chemist's Exploration of Two-Dimensions

    Science.gov (United States)

    Wassei, Jonathan Khalil

    Graphene, the first two-dimensional crystal ever studied, has made such an impact in a myriad of fields ranging from physical science to engineering that its discovery earned Nobel recognition in 2010. Although it was initially lauded as the answer to the Moore's law limitation of silicon electronics, what really captivated scientists was the fact that it opened countless avenues of exploration. From a synthetic chemists perspective, it became imperative to find a more sensible way to isolate graphene if it were ever to become practical for industrial use. This thesis demonstrates several fascinating routes to synthesize graphene, such as: top down methods involving the solution processing of graphitic materials through redox chemistry and bottom-up approaches mainly using chemical vapor deposition (CVD). In addition, several device architectures were developed to exploit intrinsic properties of the derived graphene. These applications include: transparent electrodes, Flash memory devices and bio-electrodes for cell stimulation.

  4. “Hell no, they’ll think you’re mad as a hatter”

    DEFF Research Database (Denmark)

    Ringer, Agnes; Holen, Mari

    2015-01-01

    This article examines how discourses on mental illness are negotiated in mental health practice and their implications for the subjective experiences of psychiatric patients. Based on a Foucauldian analysis of ethnographic data from two mental health institutions in Denmark—an outpatient clinic a...

  5. “So under ‘cause for concern’, I’ll write that…”

    DEFF Research Database (Denmark)

    Aamann, Iben Charlotte; Dybbroe, Betina

    2017-01-01

    Målet med artiklen er at pege på og diskutere hvordan klasse får betydning for i public health interventions in schools Forebyggelse af risici og sundhedsfremme for børn og unge er i dag centrale i sundhedspolitik, samtidig med at forældrepraksis anses for determinerende for barnets sundhed og tr...

  6. The analysis of B-d ->(eta, eta ')l(+)l(-) decays in the standard model

    NARCIS (Netherlands)

    Erkol, G; Turan, G

    We study the differential branching ratio, the branching ratio and the CP-violating asymmetry for the exclusive B-d --> (eta,eta')l(+)l(-) decays in the standard model. We deduce the B-d --> (eta,eta') form factors from the form factors of B --> pi available in the literature, by using the SU(3)(F)

  7. Solution Mask Liquid Lithography (SMaLL) for One-Step, Multimaterial 3D Printing.

    Science.gov (United States)

    Dolinski, Neil D; Page, Zachariah A; Callaway, E Benjamin; Eisenreich, Fabian; Garcia, Ronnie V; Chavez, Roberto; Bothman, David P; Hecht, Stefan; Zok, Frank W; Hawker, Craig J

    2018-06-21

    A novel methodology for printing 3D objects with spatially resolved mechanical and chemical properties is reported. Photochromic molecules are used to control polymerization through coherent bleaching fronts, providing large depths of cure and rapid build rates without the need for moving parts. The coupling of these photoswitches with resin mixtures containing orthogonal photo-crosslinking systems allows simultaneous and selective curing of multiple networks, providing access to 3D objects with chemically and mechanically distinct domains. The power of this approach is showcased through the one-step fabrication of bioinspired soft joints and mechanically reinforced "brick-and-mortar" structures. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. ll social ed il mobile commerce secondo gli esperti di digital marketing

    OpenAIRE

    Latorre Annaluce; Vernuccio Maria

    2014-01-01

    Advances in social media and mobile communication have ledto the development of "social" and "mobile commerce". Stemming from aliterature review, this paper aims to explore practitioners' interpretative perspective of the phenomena. To this purpose, we have drawn upon 25 in-depth interviews with Italian digital marketing specialists and examined their point of view using content analysis techniques. The findings show the characteristics, potentialities and critical aspects of "social" and "mo...

  9. You'll never crawl alone: Neurophysiological evidence for experience-dependent motor resonance in infancy

    DEFF Research Database (Denmark)

    van Elk, Michiel; van Schie, Hein; Hunnius, Sabine

    2008-01-01

    Lately, neuroscience is showing a great interest in examining the functional and neural mechanisms which support action observation and understanding. Recent studies have suggested that our motor skills crucially affect the way in which we perceive the actions generated by others, by showing...... stronger motor resonance for observation of actions that are established in one's motor repertoire. In the present study we extend previous findings that were based on expert motor skills in adults to the natural development of actions in infants. To investigate the effect of natural motor experience...... on motor resonance during action observation, 14- to 16-month-old infants' EEG was recorded during observation of action videos. Stronger mu- and betadesynchronizations were found for observation of crawling compared to walking videos and the size of the effect was strongly related to the infant's own...

  10. You'll Be Surprised - Digital Business Strategy as Driver of Organizational Innovativeness

    DEFF Research Database (Denmark)

    Wunderlich, Nico; Beck, Roman

    2018-01-01

    The presence of digital infrastructures fundamentally changes market conditions, business and IT strategy, and consequently organizational structures. This research investigates how the concept of a digital business strategy leads to increased organizational innovativeness and firm performance. We...... significantly higher influenced by the IT knowledge of business employees in organizations giving the digital business strategy high importance, whereas the top management team IT knowledge plays a greater role when digital business strategy is given low priority. By this research, we deliver first results...... of consequences for organizations conducting a digital business strategy and contribute to the discussion on IT-enabled innovation, CIO leadership, and the increasing relevance of organization-wide IT capabilities....

  11. Preliminary site investigation for LL and IL radwaste disposal for Qinshan NPP

    International Nuclear Information System (INIS)

    Huang Yawen; Chen Zhangru

    1993-01-01

    With the purpose of selecting a disposal site for the low- and intermediate-level radwastes arising from Qinshan NPP, site investigations were carried out in several districts of Zhejiang Province. Investigation objectives included the circumstances of geology, hydrogeology, environmental ecology, and social economy. On the basis of collected data, five possible sites were recommended for policy-making reference and further investigation

  12. Eesti maakondade klasteranalüüs ja regionaalsed valikud / Annemari Päll

    Index Scriptorium Estoniae

    Päll, Annemari

    2003-01-01

    Artikkel analüüsib tuginedes peamistele sotsiaalmajanduslikele näitajatele piirkondliku jaotuse kujunemist aastatel 1996-2000 ja annab hinnangu senise regionaalpoliitika tulemuslikkusele. Tabelid. Graafik

  13. Eesti "väikestel" jõudu küll / Juhan Teder

    Index Scriptorium Estoniae

    Teder, Juhan, 1960-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 9. jaan. 2008 lk. 8. Uuringust "Flash Eurobarometer No 196: Observatory of European EMEs" selgub, et Eesti väike- ja keskmise suurusega ettevõtted on teistega võrreldes päris edukad. Tabel: Uuring

  14. I'll Go to the Library Later: The Relationship between Academic Procrastination and Library Anxiety.

    Science.gov (United States)

    Onwuegbuzie, Anthony J.; Jiao, Qun G.

    2000-01-01

    Investigated the relationship between academic procrastination due to fear of failure and task aversiveness, and library anxiety at the graduate level. Results of the Library Anxiety Scale, Procrastination Assessment Scale-Students, and Pearson product-moment correlations showed procrastination was related to affective barriers, comfort with the…

  15. You mob my owl, I'll mob yours: birds play tit-for-tat game

    Science.gov (United States)

    Krama, Tatjana; Vrublevska, Jolanta; Freeberg, Todd M.; Kullberg, Cecilia; Rantala, Markus J.; Krams, Indrikis

    2012-01-01

    Reciprocity is fundamental to cooperative behaviour and has been verified in theoretical models. However, there is still limited experimental evidence for reciprocity in non-primate species. Our results more decisively clarify that reciprocity with a tit-for-tat enforcement strategy can occur among breeding pied flycatchers Ficedula hypoleuca separate from considerations of byproduct mutualism. Breeding pairs living in close proximity (20–24 m) did exhibit byproduct mutualism and always assisted in mobbing regardless of their neighbours' prior actions. However, breeding pairs with distant neighbours (69–84 m) either assisted or refused to assist in mobbing a predatory owl based on whether or not the distant pair had previously helped them in their own nest defense against the predator. Clearly, these birds are aware of their specific spatial security context, remember their neighbours' prior behaviour, and choose a situation-specific strategic course of action, which could promote their longer-term security, a capacity previously thought unique to primates. PMID:23150772

  16. Targeting MED1 LxxLL Motifs for Tissue-Selective Treatment of Human Breast Cancer

    Science.gov (United States)

    2013-09-01

    AU U UG AU AU CG UA GC au gc gc AA AA AU CG UA GC UA CG UA AU UA UA CG CG UA UA GC GC AU CG GC GU 5́ 3́ U U MG aptamer Survivin siRNA Folate ...DNA/RNA sequence FIGURE 19.5 Diagram of RNA nanoparticle harboring malachite green aptamer, survivin siRNA and folate -DNA/RNA sequence for targeting...modifications were extensively exam- ined to increase its stability in serum by fluori- nation, methylation , and addition of a 3’-3’-linked

  17. Tekla Structures -ohjelmiston soveltuvuus tietomallipohjaiseen rakenne- ja elementtisuunnitteluun Venäjällä

    OpenAIRE

    Rantala, Lauri

    2011-01-01

    Tämän insinöörityön tavoitteena oli tutkia suomalaisen ja venäläisen normiston mukaista tietomallipohjaista rakenne- ja elementtisuunnitteluprosessia sekä Tekla Structures –ohjelmiston soveltuvuutta venäläiseen elementtisuunnitteluun. Insinöörityössä tutkittiin, miten mallinnustyö onnistuu ja onko mallintaminen taloudellisesti kannattavaa. Lisäksi Tekla Structures –ohjelmistoa kehitettiin Rakennesuunnittelutoimisto Sormunen & Timonen Oy:n tarpeiden mukaiseksi. Aluksi työssä per...

  18. Relationships between ozone and other photochemical products at Ll. Valby, Denmark

    DEFF Research Database (Denmark)

    Skov, H.; Egeløv, A.H.; Granby, K.

    1997-01-01

    literature results it is estimated that the non-photochemical background mixing ratio of O-3 in the Northern Hemisphere is 24+/-6 ppbv. The correlation of HCOOH and CH3COOH with Ox indicates that these acids are of photochemical origin. A high correlation of HNO3 with Ox is also found. The anti-correlation...

  19. "I'll never forget this": evaluating a pilot workshop in effective communication for dental students.

    Science.gov (United States)

    Lucander, Henriette; Knutsson, Kerstin; Salé, Hanna; Jonsson, Anders

    2012-10-01

    This study evaluated a pilot workshop for teaching communication skills to dental students. The methodology is based on an experiential learning approach, the use of realistic clinical scenarios, simulated patients, and an integrated teaching team of both educational researchers and dentists. Furthermore, the methodology was adapted for short workshops, which is thought to offer better possibilities for frequent and effective training of communication skills throughout the curriculum. The work-shop was piloted with groups of six to ten students from the sixth and tenth semesters (n=94). Results show that the majority of students found the tasks meaningful and well aligned with how they perceived their future profession as dentists. Most students also thought that they learned from the task. An interesting finding is that students not only found it instructive to practice how to communicate in authentic situations, but that they generally found the workshop to be thought-provoking while at the same time providing structure and intellectual tools for the future. A possible explanation for this finding is the sharing of explicit criteria for high-quality communication.

  20. Shaping Tourist LL: Language Display and the Sociolinguistic Background of an International Multilingual Readership

    Science.gov (United States)

    Bruyèl-Olmedo, Antonio; Juan-Garau, Maria

    2015-01-01

    Linguistic landscape studies increasingly focus on the variables that intertwine to generate the meaning of texts on display. International tourist resorts, largely multilingual, reveal how languages in signage combine and respond to the sociolinguistic profile of their readership. However, these settings have received scant attention in the…

  1. Oh, the places you'll go! My many colored serotonin (apologies to Dr. Seuss)

    Science.gov (United States)

    2016-01-01

    Serotonin [5-hydroxytryptamine (5-HT)] has a truly fascinating history in the cardiovascular world. Discovered in the blood, 5-HT has long been appropriately regarded as a vasoconstrictor. A multitude of in vitro studies of isolated vessels support that addition of 5-HT causes vascular contraction. In only a few cases was 5-HT a vasodilator. Moreover, the potency and threshold of 5-HT causing contraction is increased in arteries from hypertensive vs. normotensive subjects, both animal and human. As such, we and others have hypothesized that 5-HT would contribute to hypertension by elevating arterial tone. In stark contrast to these decades of findings, we observed that a chronic infusion of 5-HT into conscious rats caused a reduction in blood pressure and nearly normalized blood pressure of experimentally hypertensive rats. Going back to the early work of Irvine Page, one of the scientists who discovered 5-HT, reveals an early recognized but never understood ability of 5-HT to reduce systemic blood pressure. Our laboratory, in collaboration with colleagues around the world, has dedicated itself to understanding the mechanisms of 5-HT-induced reduction in blood pressure. This manuscript takes you through a brief history of the discovery of 5-HT, in vitro serotonergic pharmacology of blood vessels, in vivo work with 5-HT and our studies that suggests the venous vasculature, potentially in combination with small arterioles, may be important to the actions of 5-HT in reducing blood pressure. 5-HT has certainly ended up in a place I never expected it to go. PMID:27663771

  2. Accident at TEPCo’s Fukushima-Daiichi NPP - LL for Operator/Industry

    International Nuclear Information System (INIS)

    Omoto, Akira

    2011-01-01

    Lessons Learned - Emergency Management: • Loss of communication tool and plant information (SPDS) at NPP; • Dissemination of information: - Damage to social infrastructure by earthquake hampered dissemination of information to local government and residents: - Lack of Information sharing with local residents on dispersion of FP (SPEEDI) and risk of radiation with neighboring countries on release of slightly-contaminated water: - “Data but not information”; •Who is in charge?: - Ambiguity in delineation of responsibility; - Recognized role by Joint (Government and TEPCO) ERC and local resources center 20—30km away from NPP; • Offsite center: function was lost by loss of electricity and radiation; • Effective channeling of emergency supports: - Systematize domestic/foreign helping hands for logistics/experts

  3. 'You'll See That Everywhere': Institutional Isomorphism in Secondary School Subject Departments

    Science.gov (United States)

    Puttick, Steven

    2017-01-01

    This paper asks why spatially separated school departments might exhibit, in different ways, very similar practices. Data from an ethnographic study of three secondary school geography departments in England are discussed through a concept of "isomorphism" (homogenising forces), drawn from neo-institutional theory. Similarities across…

  4. If I don't laugh, I'll cry: Exploring humor coping in breast cancer.

    Science.gov (United States)

    Melton, Laura M

    2016-01-01

    This study examined the relationship among humor coping, optimism, neuroticism, and depression in a sample of breast cancer survivors and matched control participants. Breast cancer survivors reported marginally lower levels of depression than the controls. In both groups, humor coping was not related to depression, optimism, or neuroticism, but depression was correlated negatively with optimism and positively with neuroticism. In the breast cancer group, humor coping was correlated with the coping subscales of self-distraction, positive reframing, planning, and active coping. In the control group, humor coping was correlated with the coping sub-scales of self-distraction, positive reframing, planning, venting, and using instrumental support. These results suggest either that humor coping is not a stable variable or that whether humor is a positive or negative coping technique depends partly on the population under study.

  5. Fiber reinforced concrete: an advanced technology for LL/ML radwaste conditioning and disposal

    International Nuclear Information System (INIS)

    Tchemitcheff, E.; Verdier, A.

    1993-01-01

    Radioactive waste immobilization is an integral part of operations in nuclear facilities. The goal of immobilization is to contain radioactive materials in a waste form which can maintain its integrity over very long periods of time, thus effectively isolating the materials from the environment and hence from the public. This is true regardless of the activity of the waste, including low-, and medium-level waste (LLW, MLW). A multiple-year research effort by Cogema culminated in the development of a new process to immobilize nuclear waste in concrete containers reinforced with metal fibers. The fiber concrete containers satisfy all French safety requirements relating to waste immobilization and disposal, and have been certified by Andra, the national radioactive waste management agency. The fiber concrete containers have been fabricated on a production scale since July 1990 by Sogefibre. (author). 3 refs., 5 figs., 7 tabs

  6. FAILURE MECHANISMS OF THERMAL BARRIER COATINGS INTERNAL COMBUSTION ENGINES AND llMPROVEMENTS

    Directory of Open Access Journals (Sweden)

    ADNAN PARLAK

    2003-04-01

    Full Text Available MechanicaJ properties of high performance ceramics have been improved to the point where their use in heat engines is possible. The high temperature strength and low thermal expansion properties of bigh performance ceramics offer an advantage over metals in the development of non-water cooling engine. However, because bard environment in diesel engine combustion chamber, solving the problem of durabiUty of TBC is important. DurabiUty of thermal barrier coatings(TBC is liınited by two main failure mechanisms: Therınal expansion nlİsmatch betwcen bond coat and top coat and bond coat oxidation. Both of these can cause failure of the ceramic top coat. Developments of recent years sholv that bond coats \\Vith higher oxidation resistance tend to have better coating system cyclic lives

  7. Manual for Bilingual Dictionaries. Textbook, Word List A-L, and Word List LL-Z.

    Science.gov (United States)

    Robinson, Dow F.

    Volume One of this handbook for the preparation of bilingual dictionaries deals with (1) the purpose and structure of the bilingual dictionary for which this manual is designed; (2) the grammatical form of a main entry; (3) the grammatical designation of vernacular entries; (4) gloss in Spanish and vernacular; (5) sense discriminations; (6)…

  8. Ah, neid venelasi küll! / Märt Väljataga

    Index Scriptorium Estoniae

    Väljataga, Märt, 1965-

    2004-01-01

    Rets. rmt.: Figes, Orlando. Natasha tants. Venemaa kultuurilugu. Tallinn, 2003 ; Lotman, Juri. Vestlusi vene kultuurist. Vene aadli argielu ja traditsioonid 18. sajandil ja 19. sajandi algul. 1. köide. Tallinn, 2003

  9. *J.S., Ogeh and E. Ukodo Fu ll L eng th R esearch A rticle

    African Journals Online (AJOL)

    Results showed that BL had the highest organic carbon content with a range values of (6.00 – 30.30g/kg ) and. US had the lowest organic carbon ... forest or agricultural field, soil properties vary from the summit of a hill down to the bottom slope. ..... crop production in five ecological zones of. Western Nigeria. Proceedings of ...

  10. Antibacterial Therapy for Nosocomial Pneumonias Caused by Multidrug-Resistant Microorganisms in Critical 1ll Patients

    Directory of Open Access Journals (Sweden)

    V. V. Moroz

    2007-01-01

    Full Text Available The paper presents the results of using the fourth-generation cephalosporin maxicef in the treatment of 20 patients with nosocomial pneumonia and severe concomitant injury. A control group comprised 20 patients receiving a combination of ceftazidime and amikacin. The total efficiency of the antibacterial therapy was 68.5% in the maxicef group and 40.9% in the control group (р<0.05. The therapy had to be modified in 42% of the maxicef group and in 72.7% in the control group (р<0.05. The average treatment cost was US $518 (429—606 and US $482 (368—596 in the maxicef and control groups, respectively. Nephrotoxicity was observed in 9% of the patients receiving a combination of the antibiotics. The activity of maxicef was also analyzed in vitro. Results. Maxicef was demonstrated to be highly active against the majority of gram-negative and gram-positive bacteria in vitro. Its efficacy against the most common bacteria (P.aeruginosa, S.aureus, E.coli, K.pneumonia causing infections in severe injury was in vitro significantly higher than that of ceftazidime. The comparative study indicates that the fourth-generation cephalosporin maxicef may be used as an alternative to the standard combined therapy. Key words: concomitant injury, maxicef, nosocomial pneumonia, a combination of ceftazidime and aminoglycoside, nosocomial infection pathogens.

  11. "When you're desperate you'll ask anybody": young people's social sources of tobacco.

    Science.gov (United States)

    Marsh, Louise; Dawson, Anna; McGee, Rob

    2013-04-01

    This study sought to examine young New Zealand smokers' access to social supplies of cigarettes. A qualitative investigation using 10 focus groups with 66 current young smokers, aged between 15 and 17 years, was conducted throughout New Zealand, between October and December 2011. Transcripts from the focus groups were analysed using NVivo to code the data, from which common themes and critical issues were identified. Family was one of the main sources of tobacco for the young smokers in this study and parents were the leading source, often purchasing tobacco for their children to smoke. Sharing tobacco within groups of friends was also very common. Additional methods were used when young smokers were desperate, including stealing, 'butt scabbing' and asking strangers. Both family and social networks continue to support smoking and supply tobacco to young people. While these networks operate, young people will continue to smoke, despite increased regulations on commercial sales to minors. Restrictions on commercial sales of tobacco to minors are increasing; however, many young people use multiple sources of tobacco, including social sources. It is likely that young people will increasingly use these social sources in the future. Interventions other than purchase restrictions are important for reducing minors' access to tobacco. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

  12. Nationella prov i NO och lärares val av undervisningsinnehåll

    Directory of Open Access Journals (Sweden)

    Eva Lundqvist

    2013-11-01

    Full Text Available From 2009/10, all pupils in Year 9 in Sweden are obliged to take a national test in one of the science subjects physics, chemistry or biology. There are several aims of the national test system, among others to support teachers’ work by concretizing the curriculum and syllabi. In this article, we examine how the introduction of national tests in science education could affect the content selection teachers express that they do in their teaching. The data consists of interviews with 29 teachers teaching science in the upper years of compulsory school. The result shows that there are three themes of contents that teachers highlight as new in the national tests; scientific argumentation, the history of science and laboratory work. In an analysis, looking through the lens of curriculum emphases, it is shown that what unites these three content areas is that emphasis put on the intellectual skills of the scientific craftsmanship. An explanation for this could be that many teachers recognize this as a key content in scientific activities, but a content that they did not teach to a large extent.

  13. Translating ancient Greek aspect: Sappho's Fr. 1 Voigt / Janika Päll

    Index Scriptorium Estoniae

    Päll, Janika, 1965-

    2007-01-01

    Vana-kreeka keele aspektist, selle kasutamisest ja tõlkimisprobleemidest Sappho luuletuse tõlkeid analüüsides. Lisas toodud ka Sappho luuletus originaalkeeles, tõlked ladina, eesti, inglise, saksa, itaalia, prantsuse ja vene keelde

  14. Koron vähennysoikeuden rajoittaminen etuyhteysyhtiöiden välillä suomessa ja venäjällä. erityisesti uudelleenluonnehdintaa silmällä pitäen

    OpenAIRE

    Semenova, Ksenija

    2016-01-01

    The purpose of this Master’s thesis is to study rules limiting deductibility of interest in taxation with related corporations by comparing rules in Finland and Russia and focusing on recharacterization of debt to equity or interest to dividend. Generally, there is a wide deductibility of interest in business taxation both in Finland and Russia. However, both countries have adopted specific rules limiting deductibility of interest in taxation. In addition to specific rules, both countries may...

  15. We'll Be Honest, This Won't Be the Best Article You'll Ever Read: The Use of Dispreferred Markers in Word-of-Mouth Communication

    OpenAIRE

    Ryan Hamilton; Kathleen D. Vohs; Ann L. McGill

    2014-01-01

    Consumers value word-of-mouth communications in large part because customer reviews are more likely to include negative information about a product or service than are communications originating from the marketer. Despite the fact that negative information is frequently valued by those receiving it, baldly declaring negative information may come with social costs to both communicator and receiver. For this reason, communicators sometimes soften pronouncements of bad news by couching them in d...

  16. Wood axial characterization of 32-year-old Croton piptocalyx Müll.Arg. Euphorbiaceae. Caracterização axial da madeira de Croton piptocalyx Müll.Arg. Euphorbiaceae com 32 anos de idade.

    Directory of Open Access Journals (Sweden)

    Amanda Aparecida VIANNA

    2017-01-01

    Full Text Available This paper aims to characterize the wood anatomy of Croton piptocalyx. To carry out an investigation of axial variation, discussing it in a functional context, helping to increase knowledge about the species. Five randomly selected 32-year-old trees were felled at the Luiz Antonio Experimental Station, located in Luiz Antonio City, São Paulo state, Brazil. From stems, discs were cut from six different stem heights (stem base, 1 m, 2 m, 3 m, 4 m, and 5 m. For each disc, samples close to the bark were removed for wood anatomy studies and specific gravity calculation. Wood anatomy of C. piptocalyx generally agrees with that of other species of the genus as described in the literature. However, variation in both quantitative and qualitative data could be related to tree age and species differences. Axial variations found in vessel element length, vessel diameter and ray height can be respectively related to the hypothesized Typical Radial Pattern based on the occurrence of shorter and narrower cells in younger parts of the wood, involving vessel element length and diameter, and mechanical requirement in the case of higher rays at the trunk base.Nosso objetivo foi caracterizar anatomicamente a madeira de Croton piptocalyx, investigando a variação axial e discutindo-a em um contexto funcional, contribuindo para aumentar o conhecimento sobre a espécie. Cortamos aleatoriamente cinco árvores com 32 anos de idade na Estação Experimental de Luiz Antonio, na cidade de Luiz Antonio, São Paulo, Brasil. Dos troncos retiramos discos em seis alturas diferentes (base do tronco, 1 m, 2 m, 3 m, 4 m e 5 m. Em cada um dos discos, retiramos amostras próximas à casca para estudos anatômicos e determinação da densidade aparente. A anatomia da madeira de C. piptocalyx em geral é similar com o que já está descrito na literatura para outras espécies do gênero. No entanto, há variações quantitativas e qualitativas, que em parte podem estar relacionadas às diferenças na idade de árvores e, obviamente, à diferença entre espécies. As variações axiais no comprimento dos elementos de vaso, diâmetro do vaso e altura do raio, devem estar relacionadas, respectivamente, ao Típico Padrão Radial, caracterizado pela ocorrência de células menores e mais estreitas em partes mais jovens da madeira (comprimento do elemento de vaso e diâmetro do vaso e aos requerimentos mecânicos, no caso dos raios mais altos na base do tronco.

  17. Wood axial characterization of 32-year-old Croton piptocalyx Müll.Arg. Euphorbiaceae. Caracterização axial da madeira de Croton piptocalyx Müll.Arg. Euphorbiaceae com 32 anos de idade.

    OpenAIRE

    Amanda Aparecida VIANNA; Eduardo Luiz LONGUI; Sandra Monteiro Borges FLORSHEIM; Israel Luiz de LIMA; Miguel Luiz Menezes FREITAS; Antonio Carlos Scatena ZANATTO; Marcelo ZANATA

    2017-01-01

    This paper aims to characterize the wood anatomy of Croton piptocalyx. To carry out an investigation of axial variation, discussing it in a functional context, helping to increase knowledge about the species. Five randomly selected 32-year-old trees were felled at the Luiz Antonio Experimental Station, located in Luiz Antonio City, São Paulo state, Brazil. From stems, discs were cut from six different stem heights (stem base, 1 m, 2 m, 3 m, 4 m, and 5 m). For each disc, samples...

  18. 2015 Uranium Mill Tailings Radiation Control Act (UMTRCA) Title ll Annual Report, L-Bar, New Mexico Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    Frazier, William [USDOE Office of Legacy Management, Washington, DC (United States); Johnson, Dick [Navarro Research and Engineering, Inc., Las Vegas, NV (United States)

    2015-11-01

    The L-Bar, New Mexico, Uranium Mill Tailings Radiation Control Act (UMTRCA) Title II Disposal Site was inspected on August 18, 2015. The tailings impoundment was in excellent condition. Erosion and vegetation measurements to monitor the condition of the impoundment cover indicated that no erosion is occurring, and perennial vegetation foliar cover at the measurement plots increased substantially compared to previous years due to above-average precipitation for the year. A short segment of the perimeter fence near the site entrance was realigned in spring 2015 because a gully was undermining the fence corner. Loose fence strands at another location were repaired during the inspection, and a section of fence needs to be realigned to avoid areas affected by deep gullies and sediment deposition. Inspectors identified no other maintenance needs or cause for a follow-up inspection. Groundwater monitoring is required every 3 years. The next monitoring event will be in 2016.

  19. "If You Have to Ask, You'll Never Know": Effects of Specialised Stylistic Expertise on Predictive Processing of Music.

    Science.gov (United States)

    Hansen, Niels Chr; Vuust, Peter; Pearce, Marcus

    2016-01-01

    Musical expertise entails meticulous stylistic specialisation and enculturation. Even so, research on musical training effects has focused on generalised comparisons between musicians and non-musicians, and cross-cultural work addressing specialised expertise has traded cultural specificity and sensitivity for other methodological limitations. This study aimed to experimentally dissociate the effects of specialised stylistic training and general musical expertise on the perception of melodies. Non-musicians and professional musicians specialising in classical music or jazz listened to sampled renditions of saxophone solos improvised by Charlie Parker in the bebop style. Ratings of explicit uncertainty and expectedness for different continuations of each melodic excerpt were collected. An information-theoretic model of expectation enabled selection of stimuli affording highly certain continuations in the bebop style, but highly uncertain continuations in the context of general tonal expectations, and vice versa. The results showed that expert musicians have acquired probabilistic characteristics of music influencing their experience of expectedness and predictive uncertainty. While classical musicians had internalised key aspects of the bebop style implicitly, only jazz musicians' explicit uncertainty ratings reflected the computational estimates, and jazz-specific expertise modulated the relationship between explicit and inferred uncertainty data. In spite of this, there was no evidence that non-musicians and classical musicians used a stylistically irrelevant cognitive model of general tonal music providing support for the theory of cognitive firewalls between stylistic models in predictive processing of music.

  20. Toomas Annus : meiega ei õnnestu küll kellelgi kokku leppida / Toomas Annus ; interv. Toivo Tänavsuu

    Index Scriptorium Estoniae

    Annus, Toomas, 1960-

    2006-01-01

    Ehitusfirma Merko nõukogu esimees vastab küsimustele, mis puudutavad olukorda Eesti kinnisvaraturul, häirivat ehituses ja linnaplaneerimises, klannimajandust, millest kirjutas Hans H. Luik, Pae karjääri, Sakala keskusega seotut, poliitiliste jõudude toetamist mõttemalli, et rikastele on rohkem lubatud ning sellega seoses Oliver Kruuda ebaseaduslikku võsalangetust, rikkust, ajakirjandust. Lisa: Merko käive ja kasum on jõudsalt kasvanud

  1. Gas exchange in young Hevea brasiliensis (Willd. Ex A. Juss. Müll. Arg. (Euphorbiaceae plants in Antioquia (Colombia

    Directory of Open Access Journals (Sweden)

    Oscar de Jesús Cordoba Gaona

    2018-01-01

    Full Text Available The aim of this study was to determine the behavior of Hevea brasiliensis from a study of photosynthetic performance in the environmental conditions of the rubber regions in northeast and lower Cauca of the department of Antioquia (Colombia as a baseline for future studies of clonal performance between different environments. Photosynthetic parameters were recorded by an infrared gas analysis, and for each of the photosynthetic parameters was estimated the area under the curve (AUC from 7 Hevea genotypes (clones. The maximum value of photosynthetic rates was reached at 8 hours in San Roque (10.97 µmol [CO2] m-2s-1 and 9 hours in Caucasia (7.84 µmol [CO2] m-2s-1. The maximum transpiration rates was 3.55 mmol [H2O] m-2s-1, in San Roque, and 5.16 mmol [H2O] m-2s-1 in Caucasia, while the maximum stomatal conductance was 0.18 mol [H2O] m-2s-1 y 0.16 mol [H2O] m-2s-1 in San Roque, and Caucasia respectively. The Caucasia-based rubber plants had higher cumulative net assimilation rates 271,934 µmol [CO2] m-2day-1, being higher than San Roque 226,287 µmol [CO2] m-2day-1. The mean carbon accumulation was obtained in San Roque (697,638 µmol [CO2] µmol photon-1day1. Hevea brasiliensis showed greater environmental adaptation with respect to gas exchange and the use of light energy in San Roque.

  2. S .4lr. T;,rls|." \\/eek. 6 , ll 16 ( 19 i6 ) DIE trn-VLOEI) VAN VERSKILLEI ...

    African Journals Online (AJOL)

    MAYNARD, L.A. & LOOSLI, J.K., 1956. Animal Nutrition. New York: McGraw-Hill. MOIR, R.I. & HARRIS, L.E., 1962. Ruminal flora studies in sheep. I. Influence of N intake upon ruminal function. J. Nutr. 77, 282. NABARRO, J.D.N., SPENCER, A.G. & STOWERS, J.M., 1952. Metabolic studies in severe diabetic ketosis. Quart. J.

  3. I'll show them: the social construction of (in)competence in survivors of childhood brain tumors.

    Science.gov (United States)

    Boydell, Katherine M; Stasiulis, Elaine; Greenberg, Mark; Greenberg, Corin; Spiegler, Brenda

    2008-01-01

    Multimodal therapy for the treatment of childhood cancer has resulted in increased survival rates, yet as growing cohorts of children mature, late effects are becoming apparent. Specifically, brain tumor survivors tend to have poor social skills, peer relationship problems, academic difficulties, and delayed college entry. This article addresses findings specific to the unique experience of childhood cancer survivors as they transition from adolescence to adulthood. Qualitative methods involving focus groups and in-depth interviews with 14 childhood cancer survivors and 22 family members were used. The dialectic of incompetence/competence pervaded all narratives. Contradictory concepts of integration/ isolation, realistic/unrealistic goals, and the need for special help/no help were underscored by respondents. The struggle to deal with these contradictory factors led to the simultaneous resistance and acceptance of feelings of competence.

  4. Archaeological excavations on the iron-smelting site in Tõdva village / Mauri Kiudsoo, Jaak Mäll, Irita Kallis

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2009-01-01

    Tõdva rauasulatuskompleksi puhul on tegemist esimese uuritud viikingiaegse rauasulatusakohaga Eestis. Uudseks võib pidada šlakianalüüsidel baseeruvat avastust, et tõenäoliselt tunti peale soomaagi ka meretekkelisi raua-mangaanikonkretsioone

  5. Kazinol Q from Broussonetia kazinoki Enhances Cell Death Induced by Cu(ll through Increased Reactive Oxygen Species

    Directory of Open Access Journals (Sweden)

    Hsue-Yin Hsu

    2011-04-01

    Full Text Available The ability of the flavan kazinol Q (KQ to induce DNA breakage in the presence of Cu(II was examined by agarose gel electrophoresis using supercoiled plasmid DNA. In KQ-mediated DNA breakage reaction, the involvement of reactive oxygen species (ROS, H2O2 and O2 - was established by the inhibition of DNA breakage by catalase and revealed DNA breakage by superoxide dismutase (SOD. The cell viability of gastric carcinoma SCM-1 cells treated with various concentrations of KQ was significantly decreased by cotreatment with Cu(II. Treatment of SCM-1 cells with 300 μM Cu(II enhanced the necrosis induced by 100 μM KQ. Treatment of SCM-1 cells with 100 mM KQ in the presence of 300 mM Cu(II increased the generation of H2O2. Taken together, the above finding suggested that KQ cotreatment with Cu(II produced increased amounts of H2O2, thus enhancing subsequent cell death due to necrosis.

  6. Momentum-space resummation for transverse observables and the Higgs p ⊥ at N3LL+NNLO

    Science.gov (United States)

    Bizoń, Wojciech; Monni, Pier Francesco; Re, Emanuele; Rottoli, Luca; Torrielli, Paolo

    2018-02-01

    We present an approach to the momentum-space resummation of global, recursively infrared and collinear safe observables that can vanish away from the Sudakov region. We focus on the hadro-production of a generic colour singlet, and we consider the class of observables that depend only upon the total transverse momentum of the radiation, prime examples being the transverse momentum of the singlet, and ϕ ∗ in Drell-Yan pair production. We derive a resummation formula valid up to next-to-next-to-next-to-leading-logarithmic accuracy for the considered class of observables. We use this result to compute state-of-the-art predictions for the Higgs-boson transverse-momentum spectrum at the LHC at next-to-next-to-next-to-leading-logarithmic accuracy matched to fixed next-to-next-to-leading order. Our resummation formula reduces exactly to the customary resummation performed in impact-parameter space in the known cases, and it also predicts the correct power-behaved scaling of the cross section in the limit of small value of the observable. We show how this formalism is efficiently implemented by means of Monte Carlo techniques in a fully exclusive generator that allows one to apply arbitrary cuts on the Born variables for any colour singlet, as well as to automatically match the resummed results to fixed-order calculations.

  7. Fiducial distributions in Higgs and Drell-Yan production at N$^3$LL+NNLO arXiv

    CERN Document Server

    Bizon, Wojciech; Gehrmann-De Ridder, Aude; Gehrmann, Thomas; Glover, Nigel; Huss, Alexander; Monni, Pier Francesco; Re, Emanuele; Rottoli, Luca; Torrielli, Paolo

    The perturbative description of certain differential distributions across a wide kinematic range requires the matching of fixed-order perturbation theory with resummation of large logarithmic corrections to all orders. We present precise matched predictions for transverse-momentum distributions in Higgs boson (H) and Drell-Yan pair (DY) production as well as for the closely related ${\\phi^{*}_\\eta}$ distribution at the LHC. The calculation is exclusive in the Born kinematics, and allows for arbitrary fiducial selection cuts on the decay products of the colour singlets, which is of primary relevance for experimental analyses. Our predictions feature very small residual scale uncertainties and display a good convergence of the perturbative series. A comparison of the predictions for DY observables to experimental data at 8 TeV shows a very good agreement within the quoted errors.

  8. Kohti samapalkkaisuutta palkkausjärjestelmiä kehittämällä : Case Tapiola-ryhmä

    OpenAIRE

    Merivirta, Sini

    2011-01-01

    Opinnäytetyö käsittelee henkilöstön tuntemuksia ja mielipiteitä samapalkkaisuuden toteutumisesta ja palkkausjärjestelmien kehittämisestä Tapiola-ryhmässä. Tapiola-ryhmä on vakuutus-, pankki-, säästö- ja sijoittajapalveluja tarjoava suomalainen yhtiöryhmä. Työnantajan lakisääteisenä velvollisuutena on edistää palkkatasa-arvoa. Yksinkertaistettuna samapalkkaisuusperiaate tarkoittaa sitä, että samasta tai samanarvoisesta työstä on maksettava samaa palkkaa sukupuolesta riippumatta. Samapalkk...

  9. I’ll be working my way back: A qualitative synthesis on the trauma experience of children

    NARCIS (Netherlands)

    van Wesel, F.; Boeije, H.R.; Alisic, E; Drost, S

    2012-01-01

    Children who experience some kind of traumatic event, such as losing a sibling, witnessing war, or being the victim of abuse or an accident, all have the need to process this event. Few theories exist about the development of posttraumatic stress disorder, specifically in traumatized children.

  10. "Give Me a Lesson and I'll Deliver It": Teaching Assistants' Experiences of Leading Primary Mathematics Lessons in England

    Science.gov (United States)

    Houssart, Jenny

    2013-01-01

    Teaching Assistants (TAs) in primary schools in England have a growing pedagogic role. For some, this sometimes includes responsibility for the whole class instead of the teacher. This article draws on 24 interview transcripts to examine the practice in the context of primary mathematics lessons and from TAs' viewpoints. Emergency cover is often…

  11. LL/ILW: Post-Qualification of Old Waste through Non-Destructive Extraction of Barrels from Cement Shields - 13535

    International Nuclear Information System (INIS)

    Oehmigen, Steffen; Ambos, Frank

    2013-01-01

    Currently there is a large number of radioactive waste drums entombed in cement shields at German nuclear power plants. These concrete containers used in the past for the waste are not approved for the final repository. Compliance with current acceptance criteria of the final repository has to be proven by qualification measures on the waste. To meet these criteria, a new declaration and new packing is necessary. A simple non-destructive extraction of about 2000 drums from their concrete shields is not possible. So different methods were tested to find a way of non-destructive extraction of old waste drums from cement shields and therefore reduce the final repository volume and final repository costs by using a container accepted and approved for Konrad. The main objective was to build a mobile system to offer this service to nuclear plant stations. (authors)

  12. Have an idea for a start-up? We’ll help you get it off the ground!

    CERN Multimedia

    Corinne Pralavorio

    2015-01-01

    A new Business Incubation Centre is opening its doors in the Pays de Gex. This is the sixth incubator launched in association with CERN, and it will support the creation of businesses using CERN technologies.   Representatives of the European Business Incubation Centres established in partnership with CERN met to share their experiences on 19 May at CERN’s IdeaSquare. Do you have an idea for bringing a technology developed at CERN to market? Would you like to start your own business? CERN and its local partners in France* are opening a new business incubator in the Pays de Gex. This incubator, named Innogex and based at the Saint-Genis-Pouilly Technoparc, welcomes entrepreneurs wishing to start a business based on a CERN technology. Innogex will offer these entrepreneurs advice, administrative and financial support and premises. The entrepreneur’s relationship with Innogex lasts at least three years and can be extended. The incubator is open to projects based on CERN techn...

  13. Keda küll huvitaks teerullid ja asfalt? = Who's interested in steamrollers and asphalt? / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2006-01-01

    Eesti Maanteemuuseum Varbusel. Sise- ja ekspositsioonikujundus: Laika, Belka & Strelka OÜ. Autorid Krista Lepland, Malle Jürgenson, kaasautor Tea Tammelaan. Maalingud: Kai Kaljo. Projekteerija: OÜ Restauraatorprojekt. Arhitekt Aarne Kann. Projekt 2001-2004, valmis 2005. Ill.: asendiplaan, 6 värv. sisevaadet, välisvaade

  14. 'It'll Look Good on Your Personal Statement': Self-Marketing amongst University Applicants in the United Kingdom

    Science.gov (United States)

    Shuker, Lucie

    2014-01-01

    "Selling yourself" through personal statements and interviews is now a standard practice for university applicants. This article draws on a multi-case-study research project to report on the self-marketing orientations of students within three 16-19 institutions in England. These orientations (active/passive; internal/external;…

  15. The Stubenberg meteorite-An LL6 chondrite fragmental breccia recovered soon after precise prediction of the strewn field

    Czech Academy of Sciences Publication Activity Database

    Bischoff, A.; Barrat, J.-A.; Bauer, K.; Burkhardt, Ch.; Busemann, H.; Ebert, S.; Gonsior, M.; Hakenmueller, J.; Haloda, J.; Harries, D.; Heinlein, D.; Hiesinger, H.; Hochleitner, R.; Hoffmann, V.; Kaliwoda, M.; Laubenstein, M.; Maden, C.; Meier, M.M.M.; Morlok, A.; Pack, A.; Ruf, A.; Schmitt-Kopplin, P.; Schonbachler, M.; Steele, R.C. J.; Spurný, Pavel; Wimmer, K.

    2017-01-01

    Roč. 52, č. 8 (2017), s. 1683-1703 ISSN 1086-9379 Institutional support: RVO:67985815 Keywords : asteroid 2008 tc3 * oxygen-isotope composition * cosmogenic nuclides Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 2.391, year: 2016

  16. Transport of S-cysteine conjugates in LL-PK1 cells and its role in toxicity

    International Nuclear Information System (INIS)

    Schaeffer, V.; Stevens, J.

    1986-01-01

    In order to study its role in S-cysteine conjugate toxicity, the transport of the nephrotoxic cysteine conjugate, S-1,2-dichlorovinyl-L-cysteine (L-DCVC), was investigated in the kidney cell line, LLC-PK1. When incubated with [ 35 S]-DCVC, accumulation of radioactivity within the cells was linear for at least 5 min with 92% of the 35 S present as unmetabolized L-DCVC. Kinetic analysis indicated two saturable uptake systems; Km = 6.8 μM and 1.6 mM; V/sub max/ = .048 and 1.4 nmol/min/mg protein. Both systems were Na + -independent and were inhibited by amino acid transport system L substrates but not substrates of systems A, ASC or organic anion transport. L-DCVC uptake at 5 μM and 500 μM was significantly greater in subconfluent cells than in confluent cultures by 5 and 2.8 fold, respectively. The presence of the non-toxic conjugates S-methyl-(SMC), S-ethyl-(SEC), S-benzyl-L- cysteine (SBC) and the D isomer of DCVC blocked the toxicity and inhibited the transport of L-DCVC in LLC-PK1 cells in the rank order of SBC > SEC congruent to D-DCVC > SMC. The metabolism of L-DCVC, previously shown to be required for cytotoxicity, was only slightly inhibited by these conjugates and did not correlate with their relative protection against toxicity. This study suggests that L-DCVC is transported into these cells by the system L transporter and that protection against toxicity by non-toxic S-cysteine conjugates is due to the inhibition of transport

  17. Conway's game of life and the ecosystem represented by Uexküll's concept of Umwelt / Solomon Marcus

    Index Scriptorium Estoniae

    Marcus, Solomon

    2001-01-01

    Conway "elu mäng" ja ökosüsteemi esitus Uexkülli omailma mudeli abil. Analüüsitakse rakuautomaatidel põhinevaid mänge, üritades demonstreerida nende semiootilisi omadusi. Järeldatakse, et ökoloogilistel protsessidel on olemas semiootiline mõõde

  18. Doktorikraadiga tööjõu vajadus Eesti erasektoris / Jaanika Meriküll, Raul Eamets, Jaan Masso

    Index Scriptorium Estoniae

    Meriküll, Jaanika

    2007-01-01

    Artikkel on uurimusest, mis on üks osa projektist "Eesti doktoriõppe kvalitedi, tulemuslikkuse ja jätkusuutlikkuse tagamise süsteem" ning käsitleb doktori- või teaduskandidaadi kraadiga tööjõu vajadust Eesti erasektoris

  19. Hombre, bienaventuranza y Dios en Suma Teológica l-ll, qq. 1-6.

    Directory of Open Access Journals (Sweden)

    Ariadne Pérez Treviño

    2013-11-01

    Full Text Available This article studies the Aquinas' proposal on Summa Theologica I-II, qq-1-6, where he studies how should the final end of the man be and concludes that it should be transcendental in a certain way, but immanent in another and that God is the immanent end; then, he studies the way in which man will get it and he finds out that it requires unity in three ways: unity between body and soul, intelligence and will, and finally, between the man, who is well disposed to contemplation and contemplation itself.

  20. The hydrolysis of iron(III) and iron(ll) ions between 25 deg C and 375 deg C

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Derek

    1971-11-15

    Some data on the stabilities of the known iron (III) and iron (II) ions are presented, that have been obtained in a theoretical study of the iron-water system at temperatures up to the critical temperature. In this study, estimates of the stability constants of the various ions in dilute solution have been made by a method based on the equations of classical thermodynamics and empirical equations for the change with temperature of ionic heat capacity. The data indicate that hydrolysis increases so rapidly with temperature that the Fe+3 - ion is practically non-existent above about 150 deg C and, except in very acid solutions, the Fe+2 - ion is a relatively minor constituent above about 250 deg C. The most stable of the ions over a wide range of conditions are probably Fe(OH){sub 2}+ , Fe(OH)+ and HFeO{sub 2}-

  1. "I'll Take Commas for $200": An Instructional Intervention Using Games to Help Students Master Grammar Skills

    Science.gov (United States)

    Bullard, Sue Burzynski; Anderson, Nancy

    2014-01-01

    Effective writing requires mastering grammar. For journalists, this mastery is critical because research shows poor grammar erodes media credibility. College writing instructors say students do not understand basic grammar concepts, and greater numbers of students are enrolling in remedial writing classes. This quasi-experimental mixed methods…

  2. Kurat, kus sa küll täna õhtul oled? / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2009-01-01

    Martin Scorsese muusikalisest dokumentaalfilmist "Shine a Light - Valgus peale" (USA - Suurbritannia, 2008), mille keskmes on 2006.a. New Yorgi Beaconi teatris toimunud briti ansambli Rolling Stones kontsert. Ka varasematest filmidest selle ansambli kohta (Jean-Luc Godard'i "Symphaty for the Devil", Albert ja David Mayslesi "Gimme Shelter")

  3. I'll Tell You What You Think: An Exercise in Pseudoscience Debunking in an Introductory Astronomy Course

    Science.gov (United States)

    Caton, Dan

    2013-01-01

    At Appalachian State University students have to take just two semesters of a physical or biological science to satisfy the general education requirements. Most non-science major students have little time in their crowded schedules to take additional science courses, whether they want to or not, and in fact face a surcharge when taking more…

  4. Calcium - Magnesium imbalance implicated in benign prostatic hyperplasia and restoration by a phytotherapeutic drug - Croton membranaceus Müll.Arg.

    Science.gov (United States)

    Asare, George Awuku; Ngala, Robert A; Afriyie, Daniel; Adjei, Samuel; Nyarko, Adriana; Anang-Quartey, Yvonne; Asiedu, Bernice; Doku, Derek; Amoah, Brodrick Y; Bentum, Kennedy; Musah, Iddi; Mossanda, Kensese

    2017-03-11

    Calcium (Ca)- magnesium (Mg) imbalance is implicated in prostate cancer. Ca/Mg ratio increases or decreases with proliferation or apoptosis, respectively. The study examined whether this Ca/Mg imbalance exists in BPH patients and the effect of a phytotherapeutic drug on the Ca/Mg ratio. Thirty (30) BPH patients who used the ethanolic root extract of Croton membranaceus (60 mg/day) for 3 months were examined for serum Ca, Mg, phosphate, parathyroid hormone (PTH), vitamin D, prostate specific antigen (PSA) levels and renal function tests (RFT) before (BT) and after treatment (AT) alongside thirty (30) controls. Twenty (20) trace element including Mg and Ca were determined in the drug by neutron activation analysis (NAA). RFT, PTH and vitamin D for BT, AT and controls (C) were normal. Mean PSA was 1.0 ± 0.64 (C), 27.9 ± 19.0 (BT) and 16.2 ± 11.8 ng/mL (AT) (p = 0.002). Mg, Ca/Mg ratio BT, AT and control were significantly different (p = 0.0001, respectively). After treatment, Mg and Ca/Mg ratio were not different from controls. The prevalence of Ca/Mg imbalance was 80% (BT), 13.3% (AT) and 3.3% (control group). Ca/Mg ratio imbalance is associated with BPH. This has previously not been demonstrated. The imbalance was significantly corrected after treatment with the phytotherapeutic drug.

  5. ["Give her booze and she'll loosen up": gender violence in Northeast Brazilian forró lyrics and parties].

    Science.gov (United States)

    Brilhante, Aline Veras Morais; Nations, Marilyn Kay; Catrib, Ana Maria Fontenelle

    2018-03-08

    Violence against women is primarily a socially produced issue of gender-hierarchy cultural values. This study aimed to unveil the meanings assigned to sexual violence against women in the forró lyrics by adolescent boys living on the outskirts of Fortaleza, Ceará State, Brazil. Our point of departure was ethnomusicology, the theory of which contends that studies of regional songs and their performances transcend the geographic space in which they are performed, to the extent that they reflect universally disseminated practices in the legitimation of violence. The study was conducted in state public schools in the Bom Jardim neighborhood on the outskirts of Fortaleza. This neighborhood has the highest rates of violence against women in the city. Focus groups were conducted with six to eight participants each, debating three forró songs whose lyrics referred to sexual violence. The results showed that the lyrics reproduce and influence patriarchal ideologies among Northeast Brazilian youth. Quotes by the boys reveal the discourse of "reverse rape", which seeks to condone sexual violence through the reversal of gender roles, ignoring socially constructed asymmetries. Forró proves to be a gender arena in which gladiators compete to flaunt notions of manhood, sexuality, and gender relations, replicating the dominant sexism in contemporary Brazilian society and contributing to the perpetuation of violence against women.

  6. The removal of toxic metals from liquid effluents by ion exchange resins. Part lll:Copper(ll/Sulphate/Amberlite 200

    Directory of Open Access Journals (Sweden)

    Alguacil, F. J.

    2003-06-01

    Full Text Available Copper(II adsorption from aqueous sulphate media on Amberlite 200 was investigated. The influence of operating variables such as aqueous pH, temperature and copper concentration on the metal adsorption kinetics was measured. The copper{II uptake is best fitted to the film-diffusion controlled process. The resin has been used in minicolumns to investigate its performance under dynamics conditions. Copper(II desorption from the resin is accomplished using sulphuric acid solutions.

    Se estudia la adsorción de cobre(II, de disoluciones en medio sulfato, en la resina Amberlite 200. La cinética de adsorción del metal se ha estudiado en función de una serie de variables experimentales: pH de la fase acuosa, temperatura y concentración del metal en el medio acuoso. La adsorción de cobre(II se puede correlacionar como controlada por un proceso de difusión en capa límite. Se ha utilizado la resina en minicolumnas para estudiar su comportamiento bajo condiciones dinámicas. La desorción del cobre(II se lleva a cabo con disoluciones de ácido sulfúrico.

  7. Riia literaatide õnnesoovid Tartu Akadeemiale 1632. aastal / tlk. ja komment. [ja eessõna:] Janika Päll, Kristi Viiding

    Index Scriptorium Estoniae

    2002-01-01

    Luuletuste tekst ladina ja kreeka keeles, rööptekst eesti keeles. Eessõna lk. 2493-2501. Kokkuvõte "Congratulations by Riga literati to the Academy of Tartu in 1632", lk. 2696-2697. Acclamationes votivae sub novo auspicio Regiae Dorpatensis Academiae [---] factae ab iis, qui sunt ex ordine Literatorum Rigae Metropolitanae totius Livoniae (Õnnesoovihüüded Tartu Kuningliku Akadeemia uueks õnnelikuks alguseks [---] nende sulest, kes kuuluvad kogu Liivimaa pealinna literaatide seisusesse). Kogumik sisaldas 6 ladinakeelset ja 1 kreekakeelse luuletuse

  8. "If You Have to Ask, You'll Never Know": Effects of Specialised Stylistic Expertise on Predictive Processing of Music.

    Directory of Open Access Journals (Sweden)

    Niels Chr Hansen

    Full Text Available Musical expertise entails meticulous stylistic specialisation and enculturation. Even so, research on musical training effects has focused on generalised comparisons between musicians and non-musicians, and cross-cultural work addressing specialised expertise has traded cultural specificity and sensitivity for other methodological limitations. This study aimed to experimentally dissociate the effects of specialised stylistic training and general musical expertise on the perception of melodies. Non-musicians and professional musicians specialising in classical music or jazz listened to sampled renditions of saxophone solos improvised by Charlie Parker in the bebop style. Ratings of explicit uncertainty and expectedness for different continuations of each melodic excerpt were collected. An information-theoretic model of expectation enabled selection of stimuli affording highly certain continuations in the bebop style, but highly uncertain continuations in the context of general tonal expectations, and vice versa. The results showed that expert musicians have acquired probabilistic characteristics of music influencing their experience of expectedness and predictive uncertainty. While classical musicians had internalised key aspects of the bebop style implicitly, only jazz musicians' explicit uncertainty ratings reflected the computational estimates, and jazz-specific expertise modulated the relationship between explicit and inferred uncertainty data. In spite of this, there was no evidence that non-musicians and classical musicians used a stylistically irrelevant cognitive model of general tonal music providing support for the theory of cognitive firewalls between stylistic models in predictive processing of music.

  9. Igavese armastuse sõdalane : mitte just klassika, aga ajaloo verstapost küll / Ilmar Raag

    Index Scriptorium Estoniae

    Raag, Ilmar, 1968-

    2006-01-01

    Soome ja Hiina mütoloogiat ühendavast fantaasiafilmist "Igavese armastuse sõdalane - Jade Warrior" (Soome, Hiina, Hollandi, Eesti ühistöö) : stsenarist Iiro Küttner, režissöör Antti-Jussi Annila, võitluskunstide koreograaf Yu Yan Kai, osades - Tommi Eronen, Zhang Jingchu, Markku Peltola, Elle Kull

  10. "If You Have to Ask, You'll Never Know": Effects of Specialised Stylistic Expertise on Predictive Processing of Music

    OpenAIRE

    Hansen, Niels Chr.; Vuust, Peter; Pearce, Marcus

    2016-01-01

    Musical expertise entails meticulous stylistic specialisation and enculturation. Even so, research on musical training effects has focused on generalised comparisons between musicians and non-musicians, and cross-cultural work addressing specialised expertise has traded cultural specificity and sensitivity for other methodological limitations. This study aimed to experimentally dissociate the effects of specialised stylistic training and general musical expertise on the perception of melodies...

  11. Tomorrow I'll Be Me: The Effect of Time Perspective on the Activation of Idealistic versus Pragmatic Selves

    Science.gov (United States)

    Kivetz, Yifat; Tyler, Tom R.

    2007-01-01

    It is widely accepted that the self-system is dynamic and consists of multiple selves that emerge under different contexts. The present research describes two types of diverging self-conceptions, the idealistic and pragmatic selves. Building on a synthesis of construal level theory with research on the self, we propose that a more distal time…

  12. Career Decision-Making: "I Don't Think Twice, but It'll Be All Right"

    Science.gov (United States)

    Greenbank, Paul

    2014-01-01

    This paper is based on in-depth interviews carried out with students in their first and final years of undergraduate study. The paper examines how students approached career decision-making and the rationale underpinning the approach they adopted. The research found that students were not utilising the type of rational approaches to career…

  13. Observational evidence for composite grains in an AGB outflow: MgS in the extreme carbon star LL Pegasi

    NARCIS (Netherlands)

    Lombaert, R.; de Vries, B.L.; de Koter, A.; Decin, L.; Min, M.; Smolders, K.; Mutschke, H.; Waters, L.B.F.M.

    2012-01-01

    The broad 30 μm feature in carbon stars is commonly attributed to MgS dust particles. However, reproducing the 30 μm feature with homogeneous MgS grains would require much more sulfur relative to the solar abundance. Direct gas-phase condensation of MgS occurs at a low efficiency. Precipitation of

  14. You'll change more than I will: Adults' predictions about their own and others' future preferences.

    Science.gov (United States)

    Renoult, Louis; Kopp, Leia; Davidson, Patrick S R; Taler, Vanessa; Atance, Cristina M

    2016-01-01

    It has been argued that adults underestimate the extent to which their preferences will change over time. We sought to determine whether such mispredictions are the result of a difficulty imagining that one's own current and future preferences may differ or whether it also characterizes our predictions about the future preferences of others. We used a perspective-taking task in which we asked young people how much they liked stereotypically young-person items (e.g., Top 40 music, adventure vacations) and stereotypically old-person items (e.g., jazz, playing bridge) now, and how much they would like them in the distant future (i.e., when they are 70 years old). Participants also made these same predictions for a generic same-age, same-sex peer. In a third condition, participants predicted how much a generic older (i.e., age 70) same-sex adult would like items from both categories today. Participants predicted less change between their own current and future preferences than between the current and future preferences of a peer. However, participants estimated that, compared to a current older adult today, their peer would like stereotypically young items more in the future and stereotypically old items less. The fact that peers' distant-future estimated preferences were different from the ones they made for "current" older adults suggests that even though underestimation of change of preferences over time is attenuated when thinking about others, a bias still exists.

  15. Akıllı telefon kullanımının median sinir üzerine etkisi

    OpenAIRE

    İlik, Faik; Büyükgöl, Huseyin; Eren, Fatma A.; İlik, Mustafa K.; Kayhan, Fatih; Köse, Hatice

    2018-01-01

    Purpose: The aim of this study was to examine the effects of smartphone use on the median nerve. Materials and Methods: Participants were classified into three groups according to their smartphone use frequencies; high smartphone users (with Smartphone addiction scale (SAS) score of higher than 71), low smartphone users (SAS score less than 71) and classical type mobile phones users. The Visual analogue scale (VAS), quick-disabilities of arm, shoulder, hand (qDASH) and median nerve conduction...

  16. Cobalt(ll) Coordination Compounds of Ethyl 4-Methyl-5-Imidazolecarboxylate: Chemical and Biochemical Characterization on Photosynthesis and Seed Germination

    Science.gov (United States)

    King-Díaz, Beatriz; Montes-Ayala, Josefina; Escartín-Guzmán, Concepción; Castillo-Blum, Silvia E.; Iglesias-Prieto, Roberto; Lotina-Hennsen, Blas; Barba-Behrens, Norah

    2005-01-01

    In this work we present the synthesis, structural and spectroscopic characterization of Co2+ coordination compounds with ethyl 4-methyl-5-imidazolecarboxylate (emizco). The effects of emizco, the metal salts CoCl2.6H2O, CoBr2, Co(NO3)2.6H2O and their metal coordination compounds [Co(emizco)2Cl2], [Co(emizco)2 Br2].H2O, [Co(emizco)2 (H2O)2(NO2)2.2H2O were evaluated on photosynthesis in spinach chloroplasts. Seed germination and seedling growth of the monocotyledonous species Lolium multiflorum and Triticum aestivum and the dicotyledonous species Trifolium alexandrinum and Physalis ixocarpa were also assayed under the effect of the compounds and salts. The results showed that cobalt(II) salts and their emizco coordination compounds inhibit photosynthetic electron flow and ATP-synthesis, behaving as Hill reaction inhibitors. Coordination compounds are more potent inhibitors than the salts. It was found that the salts target is at the b6f level while the complexes targets are at QB(D1)-protein and b6f level. The QB inhibition site was confirmed by variable chlorophyll a fluorescence yield. On the other hand, emizco inhibits seed germination, root and shoot development, in both weed and crop species. Cobalt(II) coordination compounds are the most effective photosynthesis inhibitors, but they are less potent than emizco in germination and seedling growth, while the metal salts are the least active of all. PMID:18365092

  17. Cobalt(ll) Coordination Compounds of Ethyl 4-Methyl-5-Imidazolecarboxylate: Chemical and Biochemical Characterization on Photosynthesis and Seed Germination

    OpenAIRE

    King-Díaz, Beatriz; Montes-Ayala, Josefina; Escartín-Guzmán, Concepción; Castillo-Blum, Silvia E.; Iglesias-Prieto, Roberto; Lotina-Hennsen, Blas; Barba-Behrens, Norah

    2005-01-01

    In this work we present the synthesis, structural and spectroscopic characterization of Co2+ coordination compounds with ethyl 4-methyl-5-imidazolecarboxylate (emizco). The effects of emizco, the metal salts CoCl2.6H2O, CoBr2, Co(NO3)2.6H2O and their metal coordination compounds [Co(emizco)2Cl2], [Co(emizco)2 Br2].H2O, [Co(emizco)2 (H2O)2(NO2)2.2H2O were evaluated on photosynthesis in spinach chloroplasts. Seed germination and seedling growth of the monocotyledonous species Lolium multiflorum...

  18. "If You Have to Ask, You'll Never Know": Effects of Specialised Stylistic Expertise on Predictive Processing of Music

    DEFF Research Database (Denmark)

    Hansen, Niels Christian; Vuust, Peter; Pearce, Marcus

    2016-01-01

    Musical expertise entails meticulous stylistic specialisation and enculturation. Even so, research on musical training effects has focused on generalised comparisons between musicians and non-musicians, and cross-cultural work addressing specialised expertise has traded cultural specificity and s......-musicians and classical musicians used a stylistically irrelevant cognitive model of general tonal music providing support for the theory of cognitive firewalls between stylistic models in predictive processing of music.......Musical expertise entails meticulous stylistic specialisation and enculturation. Even so, research on musical training effects has focused on generalised comparisons between musicians and non-musicians, and cross-cultural work addressing specialised expertise has traded cultural specificity...... and sensitivity for other methodological limitations. This study aimed to experimentally dissociate the effects of specialised stylistic training and general musical expertise on the perception of melodies. Non-musicians and professional musicians specialising in classical music or jazz listened to sampled...

  19. That’ll Teach’em to Love Their Motherland!: Russian Youth Revisit the Battles of World War II

    Directory of Open Access Journals (Sweden)

    Olga Kucherenko

    2011-12-01

    Full Text Available The cult of World War II once again occupies a hegemonic position in the frigid, increasingly militaristic cultural climate of modern-day Russia. A matter of great pride for the overwhelming majority of Russian people, the war serves as a model for group solidarity and a means of social control. It is used as a positive, character forming experience as each new generation is initiated into it through popular culture. Three recent films, the duology We are from the Future and The Fog, take on the role of the « ceremony masters » for contemporary Russian youth in its rite of passage. Essentially the vehicles of state propaganda, the films not only explore the idiosyncrasies of the proverbial Russian character, while reviving military traditions and encouraging civic responsibility, but also reflect the deep-seated anxieties of Russian society regarding its younger members.

  20. ENRAF Series 854 Advanced Technology Gauge (ATG) with SPU ll Card for Leak Detector Use Acceptance Test Procedure

    International Nuclear Information System (INIS)

    SMITH, S.G.

    1999-01-01

    The following Acceptance Test Procedure was written to test the Enraf Series 854 ATG with SPU-II card prior to installation in the Tank Farms. The procedure sets various parameters and verifies the gauge and the alarms functionality

  1. "Robovie, You'll Have to Go into the Closet Now": Children's Social and Moral Relationships with a Humanoid Robot

    Science.gov (United States)

    Kahn, Peter H., Jr.; Kanda, Takayuki; Ishiguro, Hiroshi; Freier, Nathan G.; Severson, Rachel L.; Gill, Brian T.; Ruckert, Jolina H.; Shen, Solace

    2012-01-01

    Children will increasingly come of age with personified robots and potentially form social and even moral relationships with them. What will such relationships look like? To address this question, 90 children (9-, 12-, and 15-year-olds) initially interacted with a humanoid robot, Robovie, in 15-min sessions. Each session ended when an experimenter…

  2. “It’ll Grow Organically and Naturally": The Reciprocal Relationship between Student Groups and Disability Studies on College Campuses

    OpenAIRE

    Allegra Stout; Ariel Schwartz

    2014-01-01

    Although few colleges and universities offer undergraduate disability studies curricula, our own experiences suggest that higher education settings provide opportunities for students to engage with and act upon disability studies theories and concepts. To learn more about the interactions between undergraduate student groups and disability studies, we interviewed students and faculty on three campuses. We found that students not only access disability studies theory through both formal and in...

  3. Patogeenisten vibriobakteerien määrittäminen elintarvikkeista reaaliaikaisella PCR-menetelmällä

    OpenAIRE

    Pantsar, Harri

    2012-01-01

    Tämä opinnäytetyö suoritettiin tullilaboratoriolle, ja sen tavoitteena oli kehittää reaaliaikainen PCR-menetelmä, jolla kyettäisiin tunnistamaan patogeenisia vibriobakteereja elintarvikematriisista. Vibriot ovat gram-negatiivisia muodoltaan suoria tai jyrkästi kaartuvia sau-vabakteereja. Ne ovat motiileja ja useimmat lajikkeet omaavat yksittäisen polaarisen fla-gellan liikkumista varten. Useimmat lajikkeet ovat oksidaasi- ja katalaasipositiivisia, sekä fermentoivat glukoosia tuottamatta kaasu...

  4. 3D virtual reconstruction and visualisation of the archaeological site Castellet de Bernabé (Llíria, Spain

    Directory of Open Access Journals (Sweden)

    Cristina Portalés

    2017-05-01

    Full Text Available 3D virtual reconstruction of cultural heritage is a useful tool to reach many goals: the accurate documentation of our tangible cultural legacy, the determination of mechanical alteration on the assets, or the mere shape acquisition prior to restoration and/or reconstruction works, etc. Among these goals, when planning and managing tourism enhancement of heritage sites, it demands setting up specific instruments and tools to guarantee both, the site conservation and the visitors’ satisfaction. Archaeological sites are physical witnesses of the past and an open window to research works and scientific discoveries, but usually, the major structures do no exist nowadays, and the general public takes long time and many efforts to elaborate a mental reconstruction of the volumetry and appearance from these remains. This mental reconstruction is essential to build up a storyline that communicates efficiently the archaeological and historic knowledge and awares the public about its conservation. To develop this process of awareness about conservation, heritage interpretation starts with the mental inmersion of the visitors in the archaeological site, what 3D reconstruction definitely helps to achieve. Different technologies exist nowadays for the3D reconstruction of assets, but when dealing with archaeological sites, the data acquisition requires alternative approaches to be used, as most part of the assets do not exist nowadays. In this work, we will deal with the virtual reconstruction and visualisation of the archaeological site Castellet de Bernabé by following a mixed approach (surveying techniques and archaeological research. We further give a methodology to process and merge the real and virtual data in order to create augmented views of the site.

  5. Blink and you'll miss it: the role of blinking in the perception of magic tricks.

    Science.gov (United States)

    Wiseman, Richard J; Nakano, Tamami

    2016-01-01

    Magicians use several techniques to deceive their audiences, including, for example, the misdirection of attention and verbal suggestion. We explored another potential stratagem, namely the relaxation of attention. Participants watched a video of a highly skilled magician whilst having their eye-blinks recorded. The timing of spontaneous eye-blinks was highly synchronized across participants. In addition, the synchronized blinks frequency occurred immediately after a seemingly impossible feat, and often coincided with actions that the magician wanted to conceal from the audience. Given that blinking is associated with the relaxation of attention, these findings suggest that blinking plays an important role in the perception of magic, and that magicians may utilize blinking and the relaxation of attention to hide certain secret actions.

  6. Blink and you’ll miss it: the role of blinking in the perception of magic tricks

    Directory of Open Access Journals (Sweden)

    Richard J. Wiseman

    2016-04-01

    Full Text Available Magicians use several techniques to deceive their audiences, including, for example, the misdirection of attention and verbal suggestion. We explored another potential stratagem, namely the relaxation of attention. Participants watched a video of a highly skilled magician whilst having their eye-blinks recorded. The timing of spontaneous eye-blinks was highly synchronized across participants. In addition, the synchronized blinks frequency occurred immediately after a seemingly impossible feat, and often coincided with actions that the magician wanted to conceal from the audience. Given that blinking is associated with the relaxation of attention, these findings suggest that blinking plays an important role in the perception of magic, and that magicians may utilize blinking and the relaxation of attention to hide certain secret actions.

  7. LL13-MatModelRadDetect-PD2Jf Final Report: Materials Modeling for High-Performance Radiation Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Lordi, Vincenzo [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-12-11

    The aims of this project are to enable rational materials design for select high-payoff challenges in radiation detection materials by using state-of-the-art predictive atomistic modeling techniques. Three specific high-impact challenges are addressed: (i) design and optimization of electrical contact stacks for TlBr detectors to stabilize temporal response at room-temperature; (ii) identification of chemical design principles of host glass materials for large-volume, low-cost, highperformance glass scintillators; and (iii) determination of the electrical impacts of dislocation networks in Cd1-xZnxTe (CZT) that limit its performance and usable single-crystal volume. The specific goals are to establish design and process strategies to achieve improved materials for high performance detectors. Each of the major tasks is discussed below in three sections, which include the goals for the task and a summary of the major results, followed by a listing of publications that contain the full details, including details of the methodologies used. The appendix lists 12 conference presentations given for this project, including 1 invited talk and 1 invited poster.

  8. “Laugh or I’ll Die”: Facing Death on the Stand-up Comedy Stage

    DEFF Research Database (Denmark)

    Keisalo, Marianna Päivikki

    may be at odds with the idea that humor is supposed to be enjoyable, but stand-up comedy comes with risks for both performer and audience. What draws the comedian to keep trying, to face annihilation time after time? I suggest these high emotional stakes are part of the value of comedy, which may...... be at its most enjoyable when it provides a way to engage with fear and pain. Death is also a fairly common topic in comedy routines – death of a loved one, fear of death, etc. Thus, I present a view of stand-up comedy as facing death in both its off-stage and on-stage forms, in relation to the digressions...... on semiotic excess. Comedic digression allows – even requires – us to find new perspectives on the imperatives of life, and a well-timed improvised digression can save a show going badly. The research is based on 20 months of field work in Finland, including becoming an amateur comedian myself....

  9. "I'll stop procrastinating now!" Fostering specific processes of self-regulated learning to reduce academic procrastination.

    Science.gov (United States)

    Grunschel, Carola; Patrzek, Justine; Klingsieck, Katrin B; Fries, Stefan

    2018-01-01

    Academic procrastination is considered to be a result of self-regulation failure having detrimental effects on students' well-being and academic performance. In the present study, we developed and evaluated a group training that aimed to reduce academic procrastination. We based the training on a cyclical process model of self-regulated learning, thus, focusing on improving deficient processes of self-regulated learning among academic procrastinators (e.g., time management, dealing with distractions). The training comprised five sessions and took place once a week for 90 min in groups of no more than 10 students. Overall, 106 students completed the training. We evaluated the training using a comprehensive control group design with repeated measures (three points of measurement); the control group was trained after the intervention group's training. The results showed that our training was successful. The trained intervention group significantly reduced academic procrastination and improved specific processes of self-regulated learning (e.g., time management, concentration), whereas the untrained control group showed no change regarding these variables. After the control group had also been trained, the control group also showed the expected favorable changes. The students rated the training overall as good and found it recommendable for procrastinating friends. Hence, fostering self-regulatory processes in our intervention was a successful attempt to support students in reducing academic procrastination. The evaluation of the training encourages us to adapt the training for different groups of procrastinators.

  10. Tampereen hotellit ja Facebook : Vertailu kuuden hotellin Facebook-sivujen sisällöstä

    OpenAIRE

    Nevala, Pia

    2014-01-01

    Sosiaalisen median palveluista Facebook on Suomessa noussut suosituimmaksi sosiaaliseksi verkostoitumissivustoksi, sillä Facebookilla on arvioilta 2 193 000 suomalaiskäyttäjää. Facebookin avulla yritykset voivat helposti, nopeasti ja kohdennetusti tavoittaa suuren määrän nykyisiä sekä potentiaalisia asiakkaita. Opinnäytetyön tarkoituksena oli tutkia kuuden Tampereella toimivan majoitusliikkeen Facebook-sivujen sisältöä ja verrata niitä neljän sosiaalisen median markkinointiin opastavan t...

  11. “I’ll Be Home for Christmas”: The Role of International Maasai Migrants in Rural Sustainable Community Development

    NARCIS (Netherlands)

    Archambault, C.S.

    2013-01-01

    While the Maasai have to be among sub-Saharan Africa’s most mobile population due to their traditional transhumant pastoral livelihood strategy, compared with other neighboring ethnic groups they have been relatively late to migrate in substantial numbers for wage labour opportunities. In the

  12. “I’ll Be Home for Christmas”: The Role of International Maasai Migrants in Rural Sustainable Community Development

    Directory of Open Access Journals (Sweden)

    Caroline S. Archambault

    2013-08-01

    Full Text Available While the Maasai have to be among sub-Saharan Africa’s most mobile population due to their traditional transhumant pastoral livelihood strategy, compared with other neighboring ethnic groups they have been relatively late to migrate in substantial numbers for wage labour opportunities. In the community of Elangata Wuas in Southern Kenya, international migration for employment abroad has been very rare but promises to increase in significant numbers with the dramatic rise in education participation and diversification of livelihoods. Drawing on long-term ethnographic research and the specific experiences of the few international migrant pioneers in Elangata Wuas, this paper explores how community members assess the impacts of international migration on community sustainable development. It appears that international migration facilitates, and even exacerbates, inequality, which is locally celebrated, under an ethic of inter-dependence, as sustainable development. Particular attention is paid to the mechanisms of social control employed by community members to socially maintain their migrants as part of the community so that these migrants feel continued pressure and commitment to invest and develop their communities. Such mechanisms are importantly derived from the adaptability and accommodation of culture and the re-invention of tradition.

  13. I’ll Be Back: On the Multiple Lives of Users of a Mobile Activity Tracking Application

    Science.gov (United States)

    Lin, Zhiyuan; Althoff, Tim; Leskovec, Jure

    2018-01-01

    Mobile health applications that track activities, such as exercise, sleep, and diet, are becoming widely used. While these activity tracking applications have the potential to improve our health, user engagement and retention are critical factors for their success. However, long-term user engagement patterns in real-world activity tracking applications are not yet well understood. Here we study user engagement patterns within a mobile physical activity tracking application consisting of 115 million logged activities taken by over a million users over 31 months. Specifically, we show that over 75% of users return and re-engage with the application after prolonged periods of inactivity, no matter the duration of the inactivity. We find a surprising result that the re-engagement usage patterns resemble those of the start of the initial engagement period, rather than being a simple continuation of the end of the initial engagement period. This evidence points to a conceptual model of multiple lives of user engagement, extending the prevalent single life view of user activity. We demonstrate that these multiple lives occur because the users have a variety of different primary intents or goals for using the app. These primary intents are associated with how long each life lasts and how likely the user is to re-engage for a new life. We find evidence for users being more likely to stop using the app once they achieved their primary intent or goal (e.g., weight loss). However, these users might return once their original intent resurfaces (e.g., wanting to lose newly gained weight). We discuss implications of the multiple life paradigm and propose a novel prediction task of predicting the number of lives of a user. Based on insights developed in this work, including a marker of improved primary intent performance, our prediction models achieve 71% ROC AUC. Overall, our research has implications for modeling user re-engagement in health activity tracking applications and has consequences for how notifications, recommendations as well as gamification can be used to increase engagement. PMID:29780978

  14. Monitoring of IL/HL, LL waste repository in a clay formation: objectives, technical know-how, implementation strategy

    International Nuclear Information System (INIS)

    Grevoz, Arnaud; Mayer, Stefan; Dubois, Jean-Philippe

    2005-01-01

    In France, with regards to the monitoring of a reversible repository in a clay host formation, Andra utilised international references as input to develop its own strategy and program, e.g. IAEA TECDOC 1208 and DS-154 2004, NEA 2001 (reversibility and retrievability), EUR 21025 EN. Additionally, the French safety rule RFSIII.2.f, which aims to provide guidelines but is not a regulatory requirement, deals with 'general provisions concerning explorations'. The RFSIII.2.f distinguishes between exploration conducted from the surface, investigations to be carried out in the Underground Research Laboratory (URL) and monitoring of changes in the site while the repository is in operation. The monitoring programme responds to the three main motivations: 1. the respect of operational safety and regulatory requirements; 2. the acquisition of data to improve the understanding of processes and parameters underlying the long term safety assessment; and 3. reversibility. In that respect, Andra defines monitoring terminology by distinguishing two main activities: (i) observation (for scientific and engineering understanding and reversibility) and (ii) surveillance (related to operational and long term safety). Surveillance to contribute to the operational safety of a repository, e.g. surveillance of drift stability, fire and radiological hazards, is in line with other classical and nuclear operational safety principles and practices. Surveillance to contribute to long term safety can provide input to periodic re-evaluations of the safety analysis of a geologic repository, with a view of improving system understanding and confirming data in situ, prior to final closure of the repository. As such, it is in line with the usual regulatory guidance for Nuclear Power Plant (NPP) facilities. While it will not provide direct data on the long-term evolution of the system, it may provide some data, for example related to initial conditions or to an early transient phase, for implementation into long-term evolution models. This type of surveillance should not be considered as a way to compensate for the lack of knowledge at a previous stage. Indeed, enough confidence in models and parameters contributing to a safety case will have been acquired, for instance in a URL, prior to authorisation and operation of a repository. Such prior knowledge, however, cannot be tested on the full pre-closure time scale or length scale of a repository. The observation of host rock and repository component evolution provides information to stakeholders throughout the pre closure period. Such added knowledge may contribute to improve stakeholder confidence in the process. It is taken into account to support the decisions pertaining to a step-wise, reversible repository management. For example, it may support a decision for disposal cell closure, it allows evaluating the feasibility of waste retrieval at successive stages of a stepwise closure, and it may contribute to update the design of disposal cells or access drifts yet to be built. Monitoring activities are subject to repository-specific constraints such as: materials must not interfere with operational safety; material must not reduce long term safety significantly; materials must operate under expected environmental conditions. The establishment of monitoring activities will draw on similarities with other systems that are subject to monitoring activities (e.g. monitoring of concrete and clayey structures in dams, steel structures in pipelines, railway tunnels, etc.). The key lessons from those activities point to the importance of the correct interpretation of measurements and the need for redundancy, as well as for pre-testing and careful installation of monitoring equipment. The selection criteria for adequate monitoring methods include safety, robustness and ease of integration in an automatic data acquisition network. Andra outlined a potential and preliminary monitoring strategy, as part of a repository feasibility study. It is based on available experience gained in other large civil engineering projects. Some of the key elements are as follows. The strategy acknowledges the need to compromise between needs and constraints. It focuses monitoring efforts on a few representative waste disposal cells. It takes into account the evolving nature of a monitoring programme throughout the step-wise process of the pre-closure period. The long term performance of safety functions should not be degraded by monitoring equipment and activities. As a conclusion, monitoring can be viewed as a way to inform the safety case and to provide additional arguments to build confidence in a safety case. It also helps to assess regulatory compliance during the operation phase in line with other nuclear and other classical practices. However, monitoring during the operational period is not intended to support the pre-operational safety case and, therefore, it does not aim to compensate for a lack of confidence in the results of the site characterisation, or the URL experiments. Monitoring is an additional level of the defence-in-depth approach, using technical know-how when available and adapting it to the specific context of deep geological repository

  15. Early Solar System Alkali Fractionation Events Recorded by K-Ca Isotopes in the Yamato-74442 LL-Chondritic Breccia

    Science.gov (United States)

    Tatsunori, T.; Misawa, K.; Okano, O.; Shih, C.-Y.; Nyquist, L. E.; Simon, J. I.; Tappa, M. J.; Yoneda, S.

    2015-01-01

    Radiogenic ingrowth of Ca-40 due to decay of K-40 occurred early in the solar system history causing the Ca-40 abundance to vary within different early-former reservoirs. Marshall and DePaolo ] demonstrated that the K-40/Ca-40 decay system could be a useful radiogenic tracer for studies of terrestrial rocks. Shih et al. [3,4] determined 40K/40Ca ages of lunar granitic rock fragments and discussed the chemical characteristics of their source materials. Recently, Yokoyama et al. [5] showed the application of the K-40/Ca-40 chronometer for high K/Ca materials in ordinary chondrites (OCs). High-precision calcium isotopic data are needed to constrain mixing processes among early solar system materials and the time of planetesimal formation. To better constrain the solar system calcium isotopic compositions among astromaterials, we have determined the calcium isotopic compositions of OCs and an angrite. We further estimated a source K/Ca ratio for alkali-rich fragments in a chondritic breccia using the estimated solar system initial Ca-40/Ca-44.

  16. Nuorten tupakoinnin vähentäminen : toimenpideohjelman rakentaminen Intervention Mapping -menetelmällä

    OpenAIRE

    PARVIAINEN, PIRJO

    2006-01-01

    Vuonna 2003 toteutetun kouluterveyskyselyn mukaan Salon yläluokkien kouluissa 8.-9. luokan päivittäin tupakoivien oppilaiden osuus oli merkittävästi korkeampi kuin Varsinais-Suomessa yleensä. Salon alueen nuorten tupakoinnin yleisyyttä haluttiin vähentää. Salon terveyskeskuksen toiminnallisiin tavoitteisiin kirjattiin peruskouluikäisten nuorten tupakoinnin väheneminen neljänneksellä kahden perättäisen kouluterveyskyselyn Intervention suunnittelun välineeksi valittiin Intervention Mapping ...

  17. "Oh, homme on jälle kunst! Mida ma küll tunnis teen?" / Edna Vahter

    Index Scriptorium Estoniae

    Vahter, Edna

    2002-01-01

    Kunstiõpetusest alushariduses. Rmt. : Vahter, Edna. Kinnipüütud lehesadu : [kunstiõpetuse vihik]. - [Tallinn] : Avita, 2001; Vahter, Edna. Lumisem lumeaeg : [kunstiõpetuse vihik]. - [Tallinn] : Avita, 2001

  18. Just-in-time : on strategy annotations

    NARCIS (Netherlands)

    J.C. van de Pol (Jaco)

    2001-01-01

    textabstractA simple kind of strategy annotations is investigated, giving rise to a class of strategies, including leftmost-innermost. It is shown that under certain restrictions, an interpreter can be written which computes the normal form of a term in a bottom-up traversal. The main contribution

  19. Design and Implementation of High Performance Content-Addressable Memories.

    Science.gov (United States)

    1985-12-01

    content addressability and two basic implementations of content addressing. The need and application of hardware CAM is presented to motivate the " topic...3r Pass 4th Ps4 Pass Figure 2.15 Maximum SearchUsing All-Parallel CAM - left-most position (the most significant bit) and the other IF bits are zeros

  20. Effects of dexmedetomidine infusion during spinal anesthesia on ...

    African Journals Online (AJOL)

    Ebru Tarıkçı Kılıç

    2018-02-19

    Feb 19, 2018 ... deep hypnotic state, 40-60 as mild hypnotic, 60-80 as lower limit of awareness, and 80-100 as awareness [7]. VAS was used to assess pain. The leftmost value on the. 10-cm horizontal line represented no pain, and the rightmost value represented severe pain. The subjects indicated their levels of pain ...

  1. I’ll get there because I’m great, or am I? Narcissistic Vulnerability Moderates the Narcissistic Grandiosity – Goal Persistence Relationship

    OpenAIRE

    Roberts, Ross; Beattie, Stuart; Woodman, Tim; Manley, Harry

    2017-01-01

    Across three studies, we examined the moderating effect of narcissistic vulnerability on the relationship between narcissistic grandiosity and persistence. In Study 1 (n = 338), narcissistic grandiosity predicted greater goal-drive persistence, but only when individuals also possessed a degree of narcissistic vulnerability. In Study 2 (n = 199), we replicated these effects and demonstrated that they were independent of socially desirable responding. In Study 3 (n = 372), narcissistic vulnerab...

  2. We'll miss you Steve: how the death of a technology innovator emotionally impacts those who use and love his digital devices.

    Science.gov (United States)

    Przybylski, Andrew K

    2012-07-01

    The death of Apple co-founder Steven Jobs was accompanied by a period of public mourning. Reflections shared by both those he knew and those who were connected to him through the devices he pioneered were imbued with expressions of loss. The goal of the present research was to understand the grieving of those who knew Jobs through his devices, as a way of exploring how interpersonal emotions are shaped by relationships with technology. The findings from three studies conducted in the weeks after Jobs' death indicated demographic variability in mourning across the general population, suggesting that many people were more deeply affected by his passing. Latter studies highlighted the motivational factors that are related to the use of the Apple devices which were at play in shaping feelings of sadness and loss.

  3. "If You Look the Part You'll Get the Job": Should Career Professionals Help Clients to Enhance Their Career Image?

    Science.gov (United States)

    Hooley, Tristram; Yates, Julia

    2015-01-01

    This article presents a critical exploration of the role of career professionals in supporting people to reflect on and enhance their appearance, attractiveness and self-presentation (career image). The article is conceptual and based on a review of the broader literature on career success, appearance and attractiveness. It explores the evidence…

  4. Cu(ll) mediated ATRP of MMA by using a novel tetradentate amine ligand with oligo(ethylene glycol) pendant groups

    NARCIS (Netherlands)

    Becer, C.R.; Hoogenboom, R.; Founier, D.; Schubert, U.S.

    2007-01-01

    A novel tetradentate amine ligand namely N,N,N,N,N;,N;-hexaoligo(ethylene glycol) triethylenetetramine (HOEGTETA) was employed in the homogenous ATRP of MMA in anisole using CuBr and CuBr2 as the catalyst and ethyl 2-bromoisobutyrate (EBiB) as an initiator. The effect of the polymerization

  5. "I'll See You on IM, Text, or Call You": A Social Network Approach of Adolescents' Use of Communication Media

    Science.gov (United States)

    Van Cleemput, Katrien

    2010-01-01

    This study explores some possibilities of social network analysis for studying adolescents' communication patterns. A full network analysis was conducted on third-grade high school students (15 year olds, 137 students) in Belgium. The results pointed out that face-to-face communication was still the most prominent way for information to flow…

  6. POTENTIAL OF CARBON STORAGE OF RUBBER (Hevea brasiliensis MÃœLL. ARG. PLANTATIONS IN MONOCULTURE AND AGROFORESTRY SYSTEMS IN THE COLOMBIAN AMAZON

    Directory of Open Access Journals (Sweden)

    Hernán Jair Andrade

    2014-08-01

    Full Text Available Carbon sequestration potential of rubber (Hevea brasiliensis plantations was estimated in two production systems: monoculture and agroforestry system with copoazú (Theobroma grandiflorum, on farms of Florencia, El Doncello and Belén de los Andaquíes, in northeastern Colombian Amazon, department of Caquetá. The plantations were classified into three age classes, according to their productive stage: 1-7, 8-20 and > 20 years. The carbon storage was estimated using the methodology proposed by Andrade and Ibrahim (2003 and recommended by IPCC (2003. Tree carbon sinks were evaluated: above and below ground biomass, and necromass. The highest proportion of carbon storage was found in biomass, with 95 and 92% in monoculture plantations and agroforestry systems, respectively. In both types of production systems, carbon storage is a function of tree age and density. The carbon stored in monoculture plantations was higher than in agroforestry systems, due to a greater density of rubber trees in the first production system. This study confirms that rubber plantations have potential to capture and store atmospheric carbon. With this information, the issue of participating in carbon markets of the rubber production chain can be addressed, and therefore strengthen in the region’s competitiveness and sustainability.

  7. LPS, but not Angiotensin ll, lnduces Direct Pro-lnflammatory Effects in Cultured Mouse Arteries and Human Endothelial and Vascular Smooth Muscle Cells

    DEFF Research Database (Denmark)

    Outzen, Emilie M; Zaki, Marina; Mehryar, Rahila

    2017-01-01

    resistance-sized arteries (MRA) supported by experiments in cultured human primary endothelial and vascular smooth muscle cells. Results showed that 24-hr organ culture of mouse MRA with 10 nM Ang II had, unlike 100 ng/mL LPS, no effects on IL-6 or MCP-1 secretion, VCAM1 mRNA expression or endothelial......]-Ang II had no concentration- or time-dependent effects on IL-6 and MCP-1 secretion in human umbilical vein endothelial cells (HUVEC) and human aortic smooth muscle cells (HASMC). AGTR1 or AGTR2 mRNA expression were undetectable in HUVEC, whereas HASMC expressed only AGTR1 mRNA. In summary, contrary...... rights reserved....

  8. Ostetud lõputööga saaks ülikoolidiplomi kätte küll / Kristi Leppik

    Index Scriptorium Estoniae

    Leppik, Kristi

    2008-01-01

    Plagiaadist, autoriõigusest ja lõputööde ostmisest ajakirjandusliku eksperimendina korraldatud õigusteaduse bakalaureuse lõputöö hankimise näitel Kommenteerivad Tallinna Tehnikaülikooli ehitusteaduskonna dekaan Roode Liias, Akadeemia Nord õigusteaduste dekaan Aare Kruuser, Tartu Ülikooli majandusteaduskonna arenduspordekaan Jüri Sepp, Tallinna Ülikooli riigireaduste instituudi direktor Leif Kalev

  9. "Hell no, they'll think you're mad as a hatter": Illness discourses and their implications for patients in mental health practice.

    Science.gov (United States)

    Ringer, Agnes; Holen, Mari

    2016-03-01

    This article examines how discourses on mental illness are negotiated in mental health practice and their implications for the subjective experiences of psychiatric patients. Based on a Foucauldian analysis of ethnographic data from two mental health institutions in Denmark--an outpatient clinic and an inpatient ward--this article identifies three discourses in the institutions: the instability discourse, the discourse of "really ill," and the lack of insight discourse. This article indicates that patients were required to develop a finely tuned and precise sense of the discourses and ways to appear in front of professionals if they wished to have a say in their treatment. We suggest that the extent to which an individual patient was positioned as ill seemed to rely more on his or her ability to navigate the discourses and the psychiatric setting than on any objective diagnostic criteria. Thus, we argue that illness discourses in mental health practice are not just materialized as static biomedical understandings, but are complex and diverse--and have implications for patients' possibilities to understand themselves and become understandable to professionals. © The Author(s) 2015.

  10. "I'll look it up on the Web first": Barriers and overcoming barriers to consult for sexual dysfunction among young men.

    Science.gov (United States)

    Akre, Christina; Michaud, Pierre-André; Suris, Joan-Carles

    2010-06-12

    Our aim was to identify the barriers young men face to consult a health professional when they encounter sexual dysfunctions and where they turn to, if so, for answers. We conducted an exploratory qualitative research including 12 young men aged 16-20 years old seen in two focus groups. Discussions were triggered through vignettes about sexual dysfunction. Young men preferred not to talk about sexual dysfunction problems with anyone and to solve them alone as it is considered an intimate and embarrassing subject which can negatively impact their masculinity. Confidentiality appeared to be the most important criterion in disclosing an intimate subject to a health professional. Participants raised the problem of males' accessibility to services and lack of reason to consult. Two criteria to address the problem were if it was long-lasting or considered as physical. The Internet was unanimously considered as an initial solution to solve a problem, which could guide them to a face-to-face consultation if necessary. Results suggest that Internet-based tools should be developed to become an easy access door to sexual health services for young men. Wherever they consult and for whatever problem, sexual health must be on the agenda.

  11. Efficacy of the Direct Instruction Language for Learning (DI-LL) Program to Promote Expressive and Receptive Language in Children with Autism Spectrum Disorder

    Science.gov (United States)

    2017-07-01

    University Atlanta, GA 30322 REPORT DATE: July 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort...Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 11. SPONSOR/MONITOR’S REPORT NUMBER(S) None 12. DISTRIBUTION...information indicates that as many as 75% of children with autism spectrum disorder (ASD) have language delay ranging from moderate to extreme. Many

  12. AngularJS : yksisivuisen web-sovelluksen käyttöliittymän toteutus AngularJS:llä

    OpenAIRE

    Suomijoki, Juha

    2015-01-01

    Opinnäytetyössä tutkittiin mikä on AngularJS-JavaScript-ohjelmistokehys ja miten se soveltuu yksisivuisen web-sovelluksen käyttöliittymän toteutukseen. AngularJS on vuonna 2012 julkaistu Googlen ylläpitämä JavaScript-ohjelmistokehys, joka on tarkoitettu ensisijaisesti yksisivuisten web-sovellusten kehittämiseen. Opinnäytetyön teoriaosuudessa tutkittiin mikä AngularJS on ja mitkä ovat AngularJS:n keskeiset konseptit ja sovelluskomponentit. Tarkastelu pohjautui AngularJS:stä kirjoitettu...

  13. Prematürite Retinopatisi: İki Yıllık İzlem Sonuçlarımız

    OpenAIRE

    Dikci, Seyhan; Keskin, Halil

    2015-01-01

    Özet Amaç: Yenidoğan yoğun bakım ünitemizde takip ettiğimiz ve dış merkezlerden hastanemize refere edilen prematüre bebeklerde prematürite retinopatisi (PR) sıklığını saptamak ve hastalığın klinik gidişatını değerlendirmek. Gereç ve Yöntemler: Ocak 2012-Aralık 2013 tarihleri arasında Samsun Kadın Doğum ve Çocuk Hastalıkları Hastanesi yenidoğan yoğun bakım ünitesinde takibi yapılan ve ayrıca dış merkezlerden hastanemize refere edilen 34 hafta ve altında doğum haftası olan bebekler ile do...

  14. Vibrational circular dichroism of a 2,5-diketopiperazine (DKP) peptide: Evidence for dimer formation in cyclo LL or LD diphenylalanine in the solid state.

    Science.gov (United States)

    Pérez-Mellor, Ariel; Zehnacker, Anne

    2017-02-01

    The diastereomer diketopiperazine (DKP) peptides built on phenylalanine, namely, cyclo diphenylalanine LPhe-LPhe and LPhe-DPhe, were studied in the solid phase by vibrational circular dichroism (VCD) coupled to quantum chemical calculations. The unit structure of cyclo LPhe-LPhe in KBr pellets is a dimer bridged by two strong NH…O hydrogen bonds. The intense bisignate signature in the CO stretch region is interpreted in terms of two contributions arising from the free COs of the dimer and the antisymmetrical combination of the bound COs. In contrast, cyclo LPhe-DPhe shows no VCD signal in relation to its symmetric nature. © 2017 Wiley Periodicals, Inc.

  15. We'll never get past the glass ceiling! Meta-stereotyping, world-views and perceived relative group-worth.

    Science.gov (United States)

    Owuamalam, Chuma; Zagefka, Hanna

    2013-11-01

    This article examines the implications of perceived negativity from members of a dominant outgroup on the world views and perceived relative group worth of members of disadvantaged groups. We hypothesized that concerns about the negative opinions a dominant outgroup is perceived to hold of the ingroup (i.e., meta-stereotypes) would undermine group members' views about societal fairness. We expected this trend to be mediated by recall of previous personal experiences of discrimination. We further hypothesized that members' views about societal fairness would predict their perception of the ingroup's worth relative to the outgroup - such that undermined views about societal fairness would be associated with lower perceived ingroup worth relative to the outgroup. Taken jointly, results from two studies using two real intergroup contexts support these hypotheses and are discussed in terms of their implications for the social mobility of members of disadvantaged groups. © 2012 The British Psychological Society.

  16. Aisopose lood / Aisopos ; tõlkinud ja kommenteerinud Kaarina Rein (96, 27, 119, 126, 143, 303) ja Janika Päll (72)

    Index Scriptorium Estoniae

    Aisopos, 6.saj. e.Kr.

    2006-01-01

    Sissejuhatus lk. 395, kommentaarid lk. 587-588. - Sisu: 96: Reetor Demades ; 27: Kalur, kes vett peksis ; 72: Härjakarjus ja Herakles : [luuletus] ; 119: Zeus ja rebane ; 126: Kohtumõistja Zeus ; 143: Pilliroog ja õlipuu ; 303: Kaks nahkpauna

  17. "They'll Expect More Bad Things from Us.": Latino/a Youth Constructing Identities in a Racialized High School in New Mexico

    Science.gov (United States)

    Lechuga, Chalane Elizabeth

    2010-01-01

    This research explores how Latino/a high school students in New Mexico constitute their racial identities in this particular historical moment, the post-Civil Rights colorblind era. I explore what their chosen nomenclatures and employed discourses suggest about the relationship between their racial identities and academic achievement. The research…

  18. “A Good Citizen is What You’ll Be”: Educating Khmer Youth for Citizenship in a United States Migrant Education Program

    Directory of Open Access Journals (Sweden)

    Theresa Ann McGinnis

    2015-09-01

    Full Text Available Citizenship education is a complex and multidimensional construct. This article adds to the discussion of citizenship education by examining, ethnographically the ways the “vision” of a US Migrant Education Program is circulated through the program’s discourse practices to Khmer American children of migrant agricultural workers. The article does not discuss the formal legal status of citizenship, but the program coordinators’ beliefs about the skills and dispositions needed for the Khmer youth to become “good citizens.” Within the coordinators’ visions, the fixing of the youth’s perceived deficiencies drive the curriculum, and as such the full participation of the youth as active citizens is not achieved.

  19. Liberación de endotelina-1 por angiotensina ll en miocitos cardíacos aislados Angiotensin II-induced endothelin-1 release in cardiac myocytes

    Directory of Open Access Journals (Sweden)

    María C. Villa-Abrille

    2006-06-01

    Full Text Available Muchos de los efectos de la angiotensina II (Ang II son mediados en realidad por la acción de endotelina (ET endógena liberada y/o producida en respuesta a la Ang II. En este trabajo evaluamos la interacción Ang II/ET-1, sus consecuencias en la contractilidad cardíaca y el papel de las especies reactivas del oxígeno (EROs. Se usaron cardiomiocitos aislados de gato. La Ang II, 1 nM, produjo un efecto inotrópico positivo (EIP de 31.8±3.8% que fue cancelado por inhibición de los receptores AT1, de los receptores de ET, del intercambiador Na+/H+ (NHE, del modo inverso del intercambiador Na+/Ca2+ (NCX o por el secuestro de EROs. La Ang II, 100 nM, produjo un EIP de 70.5±7.6% que fue cancelado por inhibición de los receptores AT1 y bloqueado en parte por inhibición de los receptores de ET, del NHE, del modo inverso del NCX o por el secuestro de EROs. La Ang II, 1 nM, incrementó el ARNm de la preproET-1 lo cual fue anulado por el bloqueo de los receptores AT1. Los resultados permiten concluir que el EIP de la Ang II es debido a la acción de la ET-1 endógena liberada/formada por la Ang II. La ET-1 produce: estimulación del NHE, activación del modo inverso del NCX y un consecuente EIP. Dentro de esta cascada también participarían los EROs.Many of the effects thought to be due to angiotensin II (Ang II are due to the release/formation of endothelin (ET. We tested whether Ang II elicits its positive inotropic effect (PIE by the action of endogenous ET-1 and the role played by the reactive oxygen species (ROS in this mechanism. Experiments were performed in cat isolated ventricular myocytes in which sarcomere shortening (SS was measured to asses contractility after pharmacological interventions and the effect of Ang II on inotropism were analyzed. Ang II 1 nM increased SS by 31.8±3.8% (p<0.05. This PIE was cancelled by AT1 receptor blockade, by ET-1 receptors blockade, by Na+/H+ exchanger (NHE inhibition, by reverse mode Na+/Ca2+ exchanger (NCX blockade or by ROS scavenging. Ang II 100 nM increases SS by 70.5±7.6% (p<0.05. This PIE was completely abolished by AT1 receptors blockade and were partially bocked by ET-1 receptors blockade, by NHE inhibition, by reverse mode NCX blockade or by ROS scavenging. Ang II increased preproET-1 mRNA, effect that was blunted by AT1 receptors blockade. We conclude that Ang II induces (through its AT1 receptor release/formation of ET-1, which acting in autocrine fashion on ET receptors of the isolated myocytes increases inotropism through NHE stimulation and NCX reverse mode activation. The participation of ROS is involved is this chain of events.

  20. “I’ll be next door if you need me”. Hotels as Male Refuge and Prison in "Barton Finklinidad en "Barton Fink"

    Directory of Open Access Journals (Sweden)

    Juan González Etxeberría

    2013-01-01

    Full Text Available This article analyses the link between masculinity and spaces in Foucaultian terms of power and repression in the metonymic relationship between the hotel and the main characters in Barton Fink (Cohen, 1991. The rejection of the house in the hegemonic masculinity model due to its feminization of men increases the metaphysic dimension of the hotel, a living hell where the Cohen’s violence, merging the noir and postmodernity, shows psychopathic masculinity. Barton’s mental trip inside the hotel breaks up hierarchical binaries, and sums up the original opposites in a unity, absolutely unacceptable in reality but utterly attractive as a work of fiction. The film, an obsessive metanarrative about creation, questions the boundaries between reality and art. Masculinity is also criticized for its juxtaposition and substitution of real with hegemonic fantasies..

  1. 'And you'll suddenly realise 'I've not washed my hands': medical students', junior doctors' and medical educators' narratives of hygiene behaviours.

    Science.gov (United States)

    Cresswell, Penelope; Monrouxe, Lynn V

    2018-03-22

    Compliance to hygiene behaviours has long been recognised as important in the prevention and control of healthcare associated infections, but medical doctors still display some of the lowest rates of compliance of all healthcare workers. We aim to understand compliance to hygiene behaviours by analysing medical students', junior doctors' and medical educators' narratives of these behaviours to identify their respective attitudes and beliefs around compliance and how these are learnt during training. Such an understanding can inform future interventions to improve compliance targeted to areas of greatest need. A qualitative study, using narrative interviews (nine focus groups and one individual interview). Data were analysed thematically using inductive framework analysis. Teaching hospitals in the UK. Convenience sample of 25 participants: third-year medical students in their first clinical year (n=13), junior doctors (n=6) and medical educators (n=6). We identified four main themes: (1) knowledge, (2) constraints, (3) role models/culture and (4) hygiene as an added extra. Knowledge varied across participant groups and appeared to influence behaviours; medical students relied on what they have been told by seniors, while medical educators relied on their own knowledge and experience. There was a strong belief that evidence for the effectiveness of good hygiene behaviours is lacking. Furthermore, medical educators' behaviour appears to strongly influence others. Finally, hygiene was predominately viewed as an added extra rather than an integral part of the process. Awareness of the evidence around good hygiene needs to be improved at all levels. Medical students and junior doctors should be encouraged to consider why they are asked to perform certain hygiene behaviours in order to improve ownership of those behaviours. Medical educators need to recognise their responsibilities as role models for their junior counterparts, thereby understanding their role in developing the culture of hygiene practices within their clinical domains. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. Try it, you’ll like it—or will you? : The perils of early free-trial promotions for high-tech service adoption

    NARCIS (Netherlands)

    Foubert, B.; Gijsbrechts, Els

    The proliferation of free trials for high-tech services calls for a careful study of their effectiveness, and the drivers thereof. On the one hand, free trials can generate new paying subscribers, by allowing consumers to become acquainted with the service free of charge. On the other hand, a

  3. ANÁLlSE ESTRUTURACIONISTA DE POLíTICAS PÚBLICAS: a dualidade da política pública

    Directory of Open Access Journals (Sweden)

    Lucas Canestri de Oliveira

    2013-01-01

    Full Text Available The paper proposes to justify the creatlon 01 an analysis unlt: the duality 01 publlc poücy. It argues that thls analysis unít can reveal the rules and resources 01 techno-bureaucratic structure, and values relating to polítical actlon, which in turn affect the technical-bureaucratlc structure. The paper presents (i a theoretical synthesis 01 lhe analytical approach used, the theory 01 structuratíon (Giddens, 1978, 1989, (ii a brief literature review about the publíc pollcy concept, (iii a brlef discussion about the controversy methodoloqical theory 01 structuratíon as well the analysis unlt proposed and its analysis model. The methodoloqlcal relerence 01 the article is the technology dualíty, conceíved by Wanda Orlikowski (1992. Finally, some considerations are made on the relevance of an analytical model that includes bolh technical and moral aspects.

  4. KÜRE DÜZLEMİNDEKİ OPERATÖR RIESZ POTENSİYEL iNTEGRALINI HESAPLAMADA (p, q)'UN SINIRLlLlGI

    OpenAIRE

    Karakaş, Mehmet

    2002-01-01

    Kiire düzlemindeki Riesz potansiyel integralının lnsıni hesaplama işlemlerine ilişkin bir çol{ araştırınalar ortaya llt;oyulmuş ancak, hesaplama işlemlerind e oper atör (değişim) durumu Jlek ele alı nmamıştır . Bu araştırmada, operatör Rie�'Z potansiyel i ntegralnun lusmi hesapı ama işlemlerinin yöntem ve araştırmaya ilişl un özell iider ortaya }{oyulmuştur.

  5. KÜRE DÜZLEMİNDEKİ OPERATÖR RIESZ POTENSİYEL iNTEGRALINI HESAPLAMADA (p, q'UN SINIRLlLlGI

    Directory of Open Access Journals (Sweden)

    Mehmet Karakaş

    2002-09-01

    Full Text Available Kiire düzlemindeki Riesz potansiyel integralının lnsıni hesaplama işlemlerine ilişkin bir çol{ araştırınalar ortaya llt;oyulmuş ancak, hesaplama işlemlerind e oper atör (değişim durumu Jlek ele alı nmamıştır . Bu araştırmada, operatör Rie�'Z potansiyel i ntegralnun lusmi hesapı ama işlemlerinin yöntem ve araştırmaya ilişl un özell iider ortaya }{oyulmuştur.

  6. "You Pay Your Share, We'll Pay Our Share": The College Cost Burden and the Role of Race, Income, and College Assets

    Science.gov (United States)

    Elliott, William; Friedline, Terri

    2013-01-01

    Changes in financial aid policies raise questions about students being asked to pay too much for college and whether parents' college savings for their children helps reduce the burden on students to pay for college. Using trivariate probit analysis with predicted probabilities, in this exploratory study we find recent changes in the financial aid…

  7. Plasticidade fenotípica de Baccharis genistelloides subsp. crispa (Spreng. Joch. Müll. (2006 - Asteraceae - sob manejo orgânico

    Directory of Open Access Journals (Sweden)

    L.A. Sousa

    2014-06-01

    Full Text Available O objetivo deste trabalho, relacionado a produção orgânica, utilizou preparados homeopáticos visando incremento na biomassa e no teor de flavonóides em plantas dióicas de carqueja. Os tratamentos foram: controle com água, controle com álcool 70%, Phosphorus 12CH, Sulphur 6CH, e a combinação destas homeopatias. Variações fenotípicas foram registradas a partir da análise de crescimento, realizada quinzenalmente durante 60 dias e dos caracteres morfológicos, tais como: como altura, número de ramificações, comprimento do ramo principal, diâmetro do caule e ala caulinar mediana. Na colheita foram medidos: a fitomassa fresca/seca e o volume de raiz. Posteriormente, foi quantificado o teor de flavonóides totais conforme as análises prescritas pela Farmacopéia Brasileira. O experimento foi avaliado em delineamento de blocos casualizados (2x5x2, sendo suas médias avaliadas pelo teste Tukey e o coeficiente de variação ambiental para estimar a plasticidade. Quanto ao estudo do crescimento da planta ao longo do tempo, verificou-se aumento linear simples para a maioria das variáveis nos dois sexos. Foram detectadas respostas plásticas na maioria dos caracteres avaliados. De acordo com os resultados, em ambos os sexos, 60 dias de cultivo são suficientes para obtenção de matéria prima com teor aceitável de flavonóides, bem como para verificação dos efeitos de patogenesia e similitude na aplicação de preparados homeopáticos Phosphorus 12CH, Sulphur 6CH e sua combinação Phosphorus 12CH + Sulphur 6CH. A fitomassa e o teor de flavonóides totais foram semelhantes entre plantas dióicas durante o período de estudo.

  8. "I'll do anything to maintain my health": How women aged 65-94 perceive, experience, and cope with their aging bodies.

    Science.gov (United States)

    Bennett, Erica V; Hurd Clarke, Laura; Kowalski, Kent C; Crocker, Peter R E

    2017-06-01

    We explored how physically active women perceived, experienced, and coped with their aging bodies, and examined their perceptions of the utility of self-compassion to manage aging body-related changes. Findings from a thematic analysis of interviews with 21 women aged 65-94 revealed that they were appreciative of how their bodies worked and accepting of their physical limitations, yet concurrently critical of their body's functionality and appearance. Participants engaged in physical activity and healthy eating to maintain their health and body functionality, yet also used diet, hair styling, anti-aging creams, makeup, physical activity, and clothing to manage their appearances. To assess their bodies (in)adequacies, they engaged in upward or downward social comparisons with others their age. Participants perceived self-compassion for the aging body to be idealistic and contextual. Findings highlight the importance of health and body functionality in influencing the cognitive, emotional, and behavioral management of the aging body. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Uuring: kulude kärpimine jätkub / Urve Vilk ; kommenteerinud Jaan Rosenthal, Jaan Meikup, Piret Uudeküll ... [jt.

    Index Scriptorium Estoniae

    Vilk, Urve

    2009-01-01

    KPMG korraldatud ülemaailmne finantsjuhtide küsitlus näitas, et vaatamata juba tehtud kärbetele plaanivad organisatsioonid lähiaastatel kulusid veel kuni 25 protsendi ulatuses vähendada. Juba tehtud ja plaanitavaid kulude kärpeid kommenteerivad Eesti ettevõtete juhid

  10. If you watch it move, you'll recognize it in 3D: Transfer of depth cues between encoding and retrieval.

    Science.gov (United States)

    Papenmeier, Frank; Schwan, Stephan

    2016-02-01

    Viewing objects with stereoscopic displays provides additional depth cues through binocular disparity supporting object recognition. So far, it was unknown whether this results from the representation of specific stereoscopic information in memory or a more general representation of an object's depth structure. Therefore, we investigated whether continuous object rotation acting as depth cue during encoding results in a memory representation that can subsequently be accessed by stereoscopic information during retrieval. In Experiment 1, we found such transfer effects from continuous object rotation during encoding to stereoscopic presentations during retrieval. In Experiments 2a and 2b, we found that the continuity of object rotation is important because only continuous rotation and/or stereoscopic depth but not multiple static snapshots presented without stereoscopic information caused the extraction of an object's depth structure into memory. We conclude that an object's depth structure and not specific depth cues are represented in memory. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Tell Me Where You Are and I’ll Tell You What You Want: Using Location Data to Improve Marketing Decisions

    Directory of Open Access Journals (Sweden)

    Spann Martin

    2016-11-01

    Full Text Available Location data has become more and more accessible. Smartphone applications such as location-based services collect location data on a large scale. Up to now, most approaches have relied on past data, but new developments in machine learning and artificial intelligence will soon enable more dynamic real-time use of location data. Companies that embrace these technologies will be able to create competitive advantages. Location data offers great potential to improve a variety of marketing decisions such as targeted pricing and advertising, store locations and in-store layout. Location based advertising is currently the most common application. It allows targeting all customers within a certain distance of a store. Besides advertising, location data can be used for dynamic pricing decisions. Customers close to competitor’s locations can be charged a lower price for particular products via discounts in order to reduce switching costs. Indoor tracking can help to optimize store design or the positioning of categories and brands. Granular location data about consumers’ movements hence further allows for minimizing potential offline transaction costs based on the distances to stores.

  12. If you pick up the children, I'll do the groceries: spatial differences in between-partner interaction in out-of-home household activities

    NARCIS (Netherlands)

    Swanen, T.; Ettema, D.F.; Timmermans, H.J.P.

    2007-01-01

    While many studies have been conducted about the allocation of household duties within households, little is known about the impact of land use and accessibility on the distribution of out-of-home household tasks between spouses and about men’s participation in such activities. This paper addresses

  13. If you pick up the children, I'll do the groceries: spatial differences in between-partner interactions in out-of-home household activities

    OpenAIRE

    Schwanen, T.; Ettema, D.F.; Timmermans, Harry

    2007-01-01

    While many studies have been conducted about the allocation of household duties within households, little is known about the impact of land use and accessibility on the distribution of out-of- home household tasks between spouses and about men's participation in such activities. This paper addresses this impact, while controlling for the impact of household structure, life cycle, employment status and hours, access to transport systems, and interactions among activities in persons' activity s...

  14. If you pick up the children, I'll do the groceries: spatial differences in between-partner interactions in out-of-home household activities

    NARCIS (Netherlands)

    Schwanen, T.; Ettema, D.F.; Timmermans, Harry

    2007-01-01

    While many studies have been conducted about the allocation of household duties within households, little is known about the impact of land use and accessibility on the distribution of out-of- home household tasks between spouses and about men's participation in such activities. This

  15. "We'll Get to You When We Get to You": Exploring Potential Contributions of Health Care Staff Behaviors to Patient Perceptions of Discrimination and Satisfaction.

    Science.gov (United States)

    Tajeu, Gabriel S; Cherrington, Andrea L; Andreae, Lynn; Prince, Candice; Holt, Cheryl L; Halanych, Jewell H

    2015-10-01

    We qualitatively assessed patients' perceptions of discrimination and patient satisfaction in the health care setting specific to interactions with nonphysician health care staff. We conducted 12 focus-group interviews with African American and European American participants, stratified by race and gender, from June to November 2008. We used a topic guide to facilitate discussion and identify factors contributing to perceived discrimination and analyzed transcripts for relevant themes using a codebook. We enrolled 92 participants: 55 African Americans and 37 European Americans, all of whom reported perceived discrimination and lower patient satisfaction as a result of interactions with nonphysician health care staff. Perceived discrimination was associated with 2 main characteristics: insurance or socioeconomic status and race. Both verbal and nonverbal communication style on the part of nonphysician health care staff were related to individuals' perceptions of how they were treated. The behaviors of nonphysician health care staff in the clinical setting can potentially contribute to patients' perceptions of discrimination and lowered patient satisfaction. Future interventions to reduce health care discrimination should include a focus on staff cultural competence and customer service skills.

  16. Show me your Network and I’ll tell you who you are: Social Competence and Social Capital on Early-stage entrepreneurs (forthcoming)

    NARCIS (Netherlands)

    Lans, T.; Blok, V.; Gullikers, J.

    2015-01-01

    Recognizing that detailed work on social competence in the context of early entrepreneurial processes is still scarce and, at the same time, building further on existing work, we investigated how and to what extent social competence influences social capital among students with latent

  17. I'll See You on "Facebook": The Effects of Computer-Mediated Teacher Self-Disclosure on Student Motivation, Affective Learning, and Classroom Climate

    Science.gov (United States)

    Mazer, Joseph P.; Murphy, Richard E.; Simonds, Cheri J.

    2007-01-01

    This experimental study examined the effects of teacher self-disclosure via Facebook on anticipated college student motivation, affective learning, and classroom climate. Participants who accessed the Facebook website of a teacher high in self-disclosure anticipated higher levels of motivation and affective learning and a more positive classroom…

  18. "Hold On! I'll Just Google It!": Critical Conversations Regarding Dimensions of Diversity in a School Leadership Preparation Program

    Science.gov (United States)

    Boske, Christa; Elue, Chinasa

    2018-01-01

    This case outlines a dilemma encountered by faculty and graduate assistants in a K-12 educational administration graduate program. The case offers a detailed illustration of tensions arising when faculty were asked to increase "diversity" within their program. Faculty uncover disrupting institutional systems of domination that often play…

  19. 'If you show your real face, you'll lose 10 000 followers': The gaze of the other and transformations of shame in digitalized relationships

    Directory of Open Access Journals (Sweden)

    King Vera

    2016-01-01

    Full Text Available This essay examines the significance and transformation of shame in the context of digitalization, in particular, the psychosocial and psychological consequences of shifts in the boundaries between public and private manifest in the contemporary digital world. Moreover, it will examine the dynamic relationships of shame, humiliation and shamelessness as they develop in digital environments characterized by the dissolution of physical and communicative presence, as well as the, in turn, changing functions, ambivalences and affective pitfalls of self-presentation. On the basis of descriptions and commentaries by contemporary adolescents on the significance of social networks and on their own digital self-presentation, it will identify mechanisms for dealing with the imagined, projected or abnegated gaze of the other in the net.

  20. ‘And you’ll suddenly realise ‘I’ve not washed my hands’: medical students’, junior doctors’ and medical educators’ narratives of hygiene behaviours

    Science.gov (United States)

    Cresswell, Penelope

    2018-01-01

    Objective Compliance to hygiene behaviours has long been recognised as important in the prevention and control of healthcare associated infections, but medical doctors still display some of the lowest rates of compliance of all healthcare workers. We aim to understand compliance to hygiene behaviours by analysing medical students’, junior doctors’ and medical educators’ narratives of these behaviours to identify their respective attitudes and beliefs around compliance and how these are learnt during training. Such an understanding can inform future interventions to improve compliance targeted to areas of greatest need. Design A qualitative study, using narrative interviews (nine focus groups and one individual interview). Data were analysed thematically using inductive framework analysis. Setting Teaching hospitals in the UK. Participants Convenience sample of 25 participants: third-year medical students in their first clinical year (n=13), junior doctors (n=6) and medical educators (n=6). Results We identified four main themes: (1) knowledge, (2) constraints, (3) role models/culture and (4) hygiene as an added extra. Knowledge varied across participant groups and appeared to influence behaviours; medical students relied on what they have been told by seniors, while medical educators relied on their own knowledge and experience. There was a strong belief that evidence for the effectiveness of good hygiene behaviours is lacking. Furthermore, medical educators’ behaviour appears to strongly influence others. Finally, hygiene was predominately viewed as an added extra rather than an integral part of the process. Conclusions Awareness of the evidence around good hygiene needs to be improved at all levels. Medical students and junior doctors should be encouraged to consider why they are asked to perform certain hygiene behaviours in order to improve ownership of those behaviours. Medical educators need to recognise their responsibilities as role models for their junior counterparts, thereby understanding their role in developing the culture of hygiene practices within their clinical domains. PMID:29572392

  1. Angular analysis of B→K{sup *}ll and search for B{sup +}→K{sup +}ττ at the BELLE experiment

    Energy Technology Data Exchange (ETDEWEB)

    Wehle, Simon

    2016-09-15

    Rare decays of B mesons are an ideal probe to search for phenomena beyond the Standard Model of particle physics, since contributions from new particles can affect the decays on the same level as Standard Model predictions. The rare decay of B→K{sup (*)}l{sup +}l{sup -} offers the quark transition b→sl{sup +}l{sup -}, a flavor changing neutral current which is forbidden at tree level in the Standard Model. Higher order processes such as penguin or W{sup +}W{sup -} box diagrams allow for these processes, leading to branching ratios of less than one in a million. Various extensions to the Standard Model predict influences of new physics, which can enhance or suppress branching ratios or lead to changes in angular distributions of the decay products. In order to produce a sufficient amount of B mesons, the so-called B-factories were designed. One of them is the asymmetric-energy e{sup +}e{sup -} collider KEKB with the Belle experiment, located in Tsukuba, Japan. During 1999 to 2010 the experiment recorded a total luminosity of 1 ab{sup -1} of electron positron collisions. In this thesis a comprehensive study of the flavor changing neutral current process b→sl{sup +}l{sup -} in B meson decays with accompanying kaons is presented in two separate analyses. All three lepton modes, e{sup +}e{sup -}, μ{sup +}μ{sup -} and τ{sup +}τ{sup -} are investigated to search for evidence of physics beyond the Standard Model. The measurements are performed using the full Belle data sample of 772 x 10{sup 6} B anti B pairs, recorded at the Υ(4S) resonance energy. The first analysis in this thesis covers the muon and electron modes in the decay of B{sup 0}→K{sup *}(892){sup 0}l{sup +}l{sup -}. To maximize signal efficiency and purity, neural networks are developed sequentially from the bottom to the top of the decay chain, transferring each time the output probability to the subsequent step such that most effective selection cuts are applied in the last stage based on all information combined. Reconstructed signal yields of both channels exceed previous B-factory results of Belle and BaBar measurements, enabling a full angular analysis in this decay with the Belle data for the first time. In total 117.6±12.4 signal candidates for B{sup 0}→K{sup *}(892){sup 0}μ{sup +}μ{sup -} and 69.4±12.0 signal events for B{sup 0}→K{sup *}(892){sup 0}e{sup +}e{sup -} are observed in the data. The branching ratios of both modes are extracted and found to be in agreement with previous measurements. With the combined data of both channels, the differential decay rate is extracted in three angular dimensions in five bins of q{sup 2}, the di-lepton invariant mass squared. A series of spatial transformations is applied to reduce the number of free parameters of the differential decay rate from eight to three. With four different transformations the fit is independently sensitive to observables P{sub 4}{sup '}, P{sub 5}{sup '}, P{sub 6}{sup '} and P{sub 8}{sup '}, which are optimized regarding uncertainties arising from form-factors. Altogether 20 independent three-dimensional maximum likelihood fits are performed extracting P{sub 4,5,6}{sup '} or P{sub 8}{sup '}, the K{sup *} longitudinal polarization F{sub L} and the transverse polarization asymmetry A{sub T}. Results in the region of q{sup 2}<8 GeV{sup 2}/c{sup 4} are compared with Standard Model predictions and overall agreement is observed. One measurement is found to deviate by ∝2.1σ from the predicted value in the same direction and in the same q{sup 2} region where the LHCb collaboration reported the so called P{sub 5}{sup '} anomaly. The second analysis in this thesis is dedicated to the τ mode of b→sl{sup +}l{sup -} in the search for B{sup +}→K{sup +}τ{sup +}τ{sup -}. This mode is particularly interesting as new particles could couple to the high mass of τ leptons stronger than to e and μ. However, due to several neutrinos being present in the final state, it is difficult to find. The full reconstruction technique is used, which is unique for e{sup +}e{sup -} colliders and makes it possible to find signatures of the decay. On the control channel, B{sup +}→K{sup +}τ{sup +}τ{sup -}(K{sub S}), it is shown that the reconstruction and background suppression methods work as expected and that they deliver consistent results in both data and Monte Carlo. This analysis demonstrates using simulated events and control channels on the Belle dataset, that the current upper limit can be improved by more than one order of magnitude compared to the current value to B{sup Projected}(B{sup +}→K{sup +}τ{sup +}τ{sup -})<3.17 x 10{sup -4}, (1) at 90% confidence level including systematic uncertainties determined by an extensive study of all the sources. This limit will come close to the prediction of models developed in the context of Minimal Lepton Flavor Violation.

  2. The role of different types of instrumentality in motivation, study strategies, and performance: know why you learn, so you'll know what you learn!

    Science.gov (United States)

    Simons, Joke; Dewitte, Siegfried; Lens, Willy

    2004-09-01

    Two theories in the field of motivation and achievement, namely the future time perspective theory and goal theory, result in conflicting recommendations for enhancing students' motivation, because of their differential emphasis on the task at hand and on the future consequences of a task. We will present a framework consisting of four types of instrumentality that combines both perspectives. The implications of those different types for goal orientation, motivation, cognitive strategies, study habits and performance are investigated. Participants were a group of 184 first-year nurse students with ages ranging from 18 to 45 years. Questionnaires were administered that measured instrumentality, goal orientation, motivation, deep and surface level learning strategies, study habits, and a manipulation check. At the end of the year, exam scores were collected. The results showed that different types of instrumentality are related differently to the motivational, cognitive and achievement measures. Being internally regulated and perceiving the utility of the courses resulted both in a more adaptive goal orientation and higher intrinsic motivation, which led to the use of more adaptive cognitive strategies and to better study habits, which ultimately enhanced performance. Linking performance to extrinsic rewards and not seeing the utility of the course for the future yielded the opposite pattern. Type of instrumentality has indeed a differential influence on motivational, cognitive, and behavioural variables.

  3. Andrei Luzgin : küll Kaial tulevad võidud ja ka kõrgem reiting / Andrei Luzgin ; interv. Maarja Värv

    Index Scriptorium Estoniae

    Luzgin, Andrei

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 9. nov., lk. 13. Vestlus Eesti parima tennisisti Kaia Kanepi treeneriga, kelle arvates suudab sportlane juba tänavu tõusta maailmas viiekümne parema hulka. Lisa: Kaia Kanepi

  4. “I'll be your cigarette—Light me up and get on with it”: Examining smoking imagery on YouTube

    Science.gov (United States)

    Forsyth, Susan R.

    2010-01-01

    Introduction: Smoking imagery on the online video sharing site YouTube is prolific and easily accessed. However, no studies have examined how this content changes across time. We studied the primary message and genre of YouTube videos about smoking across two time periods. Methods: In May and July 2009, we used “cigarettes” and “smoking cigarettes” to retrieve the top 20 videos on YouTube by relevance and view count. Eliminating duplicates, 124 videos were coded for time period, overall message, genre, and brand mentions. Data were analyzed using descriptive statistics. Results: Videos portraying smoking positively far outnumbered smoking-negative videos in both samples, increasing as a percentage of total views across the time period. Fifty-eight percent of videos in the second sample were new. Among smoking-positive videos, music and magic tricks were most numerous, increasing from 66% to nearly 80% in July, with music accounting for most of the increase. Marlboro was the most frequently mentioned brand. Discussion: Videos portraying smoking positively predominate on YouTube, and this pattern persists across time. Tobacco control advocates could use YouTube more effectively to counterbalance prosmoking messages. PMID:20634267

  5. Early growth of promising rubber tree clones of Hevea brasiliensis (Willd. ex A. Juss. Müll. Arg. in an agroforestry system in Caquetá, Colombia

    Directory of Open Access Journals (Sweden)

    Armando Sterling Cuéllar

    2015-07-01

    Full Text Available This study aimed to evaluate the early growth of three rubber tree clones (Hevea brasiliensis (FX 4098, FDR 5788, and control IAN 873 in four planting systems with cupuasu (Theobroma grandiflorum and banana trees (Musa AAB at two localities in Caquetá (Colombian Amazonia. A completely randomized block design with three replications and split-plot arrangement, analyzed with a general linear mixed model, was used at each locality. Total height (AT, trunk circumference (CT, canopy area (AC and leaf area index (IAF were evaluated one and two years after establishment of rubber trees. Trunk circumference was the variable most correlated with different growth indices (r ≥ 0.94. Four growth indices were strongly influenced by temporal and clonal variation and by planting system (p < 0.01. The only significant differences between the two localities were for AC (p < 0.05. System x clone interaction was significant for IAF (p < 0.01. After two years, the highest growth indices were observed in rubber tree clone FX 4098 (AT = 4.43 m; CT = 13.00 cm, AC = 4.62 m2; LAI = 1.37, and in two of the three agroforestry systems (AT ≥ 4.08 m, CT ≥ 11.43 cm, AC ≥ 4.01 m2; IAF ≥ 1.54 compared with the control system (monoculture.

  6. Efecto de inclusión de anticoagulantes durante el beneficio de Hevea brasiliensis (Willd. ex A.Juss. Müll.Arg.

    Directory of Open Access Journals (Sweden)

    Lina Paola Mendoza Vargas

    2018-01-01

    Full Text Available Se evaluó el efecto de un agente anticoagulante del látex en el árbol de caucho (Hevea brasiliensis. Se caracterizó el contenido de solidos totales (TSC y contenido de caucho seco (DRC del látex, se evaluaron cuatro tratamientos de anticoagulantes en campo: (T1 amoniaco, (T2 bórax, (T3 amoniaco-bórax y (T0 sin anticoagulante. En las láminas se evaluaron cinco diluciones (v/v de látex en agua D1 (100 %, D2 (75 %, D3 (50 %, D4 (25 % y D5 (0 %, a estas se hicieron pruebas de tensión, compresión y espesor. El látex caracterizado obtuvo TSC (37.1 %+0.27, DRC (34.3 %+0.19. Encontrándose en T3D1 mayor resistencia de tensión hasta punto de ruptura de 13.37 KgF, compresión de 5 KgF, y menor espesor de 1.52 mm, sin diferencia significativa entre los tratamientos T3 y T2 y las diluciones D1 a D2, posibilitando reducir el consumo de agua (25 %, y la producción de ripio (38 % con anticoagulantes, sin afectar negativamente sus propiedades mecánicas.

  7. Development of myiasis vaccine: In vitro detection of immunoprotective responses of peritrophic membrane protein, first instar larva Ll supernatant and pellet antigen of fly Chrysomyia bezziana in sheep

    Directory of Open Access Journals (Sweden)

    Sukarsih

    1999-10-01

    Full Text Available Myiasis control by means of individual treatment of animals which are mainly rised extensively is time consumed and expensive. The alternative way to control this disease by vaccination is considered effective and economically accepted. However the expected vaccine is now still being developed under a collaborative project between CSIRO, Inter-University Centre on Biotechnology-ITB and Research Institute for Veterinary Science and funded by ACIAR. There are several antigens have been identified as vaccine candidates and an in vitro bioassay technique has been developed for assessing the immunoresponses of vaccine in sheep. Three antigens were used for vaccines in this study, these included protein peritrophic membrane (PM, soluble extract (SE and pellet extract (PE of 1st instar larvae of Chrysomya bezziana. Twenty four experimental sheep were divided into 4 groups of 6 animals, 3 groups of animals were injected with PM, SE and PE vaccines with the dose rate of 0.5 g PM/head, 0.8 g PE/head and 4.2 ml LE/head respectively, and the other one group was injected with 4 ml PBS/head as a control group. Vaccination with the same dose was repeated 4 weeks after the 1st vaccination as a booster, and 2 weeks after the booster the sheep were challenged with live larvae, 3 days after challenge animals were killed. Sera were collected at the day of vaccination, 4 weeks after vaccination, 2 weeks after booster, and 3 days after challenge. An in vitro bioassay technique was conducted by culturing 1st instar larvae on five media containing sera collected from each experimental animal. The effects of sera on cultivated larvae were assessed by means of larval weight and larval mortality rate. The results indicated that the growth rate and survival of cultivated larvae in media containing anti-PM sera were significantly lower (P<0.01 compared to the larvae cultivated on media with sera on the day of vaccination. The larval weight depression by anti- PM sera collected at 3 days after challenge was 65% of that larvae cultivated on media with sera collected on the day of vaccination. Anti-PM sera depressed the growth rate and survival of larvae significantly greater (P<0.05 than that of anti-PE or anti-LE sera. It is concluded that PM has the best immunoresponses and as the candidate of choice for myiasis vaccine.

  8. A validated method using RP-HPLC for quantification of reserpine in the Brazilian tree Rauvolfia sellowii Müll. Arg. (Apocynaceae

    Directory of Open Access Journals (Sweden)

    Leopoldo C. Baratto

    2012-01-01

    Full Text Available This study describes a simple, fast and reproducible method using RP-HPLC-UV, in a gradient system, for quantification of reserpine in Rauvolfia sellowii stem bark. The analysis were carried out on a C18 column; mobile phase was water and acetonitrile, and separations were carried out in 10 min, flow rate of 1.0 mL min-1, 25 ºC and 268 nm. The validation data showed that the method was specific, accurate, precise and robust. Results were linear over a range of 0.625-40.0 μg mL-1, and the mean recovery was 95.1%. The amount of reserpine found in the dried stem bark was 0.01% (m/m.

  9. Splitting diffraction peak in different thickness LL-interferometer and determination of thickness of damaged layer induced by electron irradiation of plates

    International Nuclear Information System (INIS)

    Truni, K.G.; Sedrakyan, A.G.; Papoyan, A.A.; Bezirganyan, P.A.

    1988-01-01

    Amplitude of twice reflected beam is calculated analytically, oscillatory dependence of peak intensity in the centre of diffraction image on the small variations in thickness is shown. The expression, clearly binding the splitting value of diffraction peak with variation in thickness of the interferometer plates, is received. The effect of variation in thickness on the splitting value of focal line is studied experimentally in case of irradiation of the equal-arm Π-shaped interferometer blocks by fast electron flow, thickness of the originated damaged layers are determined

  10. From Hades to Hel and from Elysium to Valhǫll : A Comparative Research about Death and Afterlife in ancient Greek and Viking society

    OpenAIRE

    Karagianni, Antonia

    2013-01-01

    The present thesis is a comparative research about death and afterlife in ancient Greek and Viking society making use of both literary sources such as the Eddas and the Homeric epic poems and archaeological evidence including ship burials, rune stones, grave steles and vase paintings. I start applying the subject of death and afterlife individually on each civilization and for this purpose the two first chapters consist of two parts; the first part deals with beliefs about death and afterlife...

  11. "Everything's Upside Down. We'll Call It Upside Down Valley!": Siblings' Creative Play Themes, Object Use, and Language during Pretend Play

    Science.gov (United States)

    Howe, Nina; Abuhatoum, Shireen; Chang-Kredl, Sandra

    2014-01-01

    Research Findings: Pretend play is an important context that supports young children's developing social-cognitive and creative abilities. The play behaviors of 70 sibling dyads in early and middle childhood were examined for the following indices of creativity in play: (a) play themes (set-up/organization, expected, creative), (b) object use…

  12. Wherever Hardware, There’ll be Games. The evolution of hardware and shifting industrial leadership in the gaming industry 1968-2004

    OpenAIRE

    Jörnmark, Jan

    2005-01-01

    Video game was the first truly digital entertainment medium, requiring processing power both in the production and consumption stage. Born out of the transistor, it was also intimately connected with its logic: the doubling of the processor capacity every 18th month or the halving of the price for the same processing capacity in the same time. Transistor technology and video games have been able to conquer society in an evolutionary process. Hence, video games have had an unprecedented abilit...

  13. "The Only Future Certainty Is that I'll Still Be Speaking to Her": Social Capital/Network for the Transition of Disadvantaged Young People

    Science.gov (United States)

    Inui, Akio; Nishimura, Takayuki

    2007-01-01

    This paper examines the significance of social network and social capital in youth transition from school to work, with a focus on both instrumental and expressive aspects. In recent years the transition of Japanese young people has changed drastically, similar to young people in other industrialised countries. The individualisation of transition…

  14. 'She'll Be Right.' Or Will She? Practitioner Perspectives on Risk Assessment for Led Outdoor Activities in Australia

    Science.gov (United States)

    Dallat, Clare; Goode, Natassia; Salmon, Paul M.

    2018-01-01

    Inadequate risk assessment has been implicated as a contributory factor in the deaths and injuries of participants on led outdoor activity (LOA) programmes in both Australia and overseas. The identification and assessment of risks is a required component of LOA programmes, and multiple risk assessment methods and techniques are available to the…

  15. Sometimes we'll have to prove that we're not crocodiles : evangelical Christians' stigmatisation as sectarians in a Komi village / Piret Koosa

    Index Scriptorium Estoniae

    Koosa, Piret

    2015-01-01

    Artiklis käsitletakse teatud sotsiaalseid pingeid mis on kaasnenud religioosse pluralismiga Venemaa postsotsialistlikus ühiskonnas. Täpsemalt uuritakse Komi näitel evangeelsete kristlaste katseid end kehtestada traditsiooniliselt ortodoksses keskkonnas

  16. "You Can Try, But You Won't Stop It. It'll Always Be There": Youth Perspectives on Violence and Prevention in Schools.

    Science.gov (United States)

    Sundaram, Vanita

    2016-02-01

    The role of schools in preventing violence among teenagers has been highlighted, as has the development of youth-led prevention initiatives. This article explores how young people's views on violence influence their perceptions of its preventability, drawing on focus group discussions with 14- to 16-year-olds from six schools across the north of England. Young people view violence as a highly individualized phenomenon, and gender norms play an important role in shaping young people's perceptions of the preventability of violence. The findings presented here suggest that school-based violence prevention must fundamentally address gender norms and expectations to challenge young people's acceptance and tolerance of violence. © The Author(s) 2014.

  17. Detection of anthraquinones and identification of 1,4-naphthohydroquinone in cell suspension cultures of Rudgea jasminoides (Cham.) Müll. Arg. (Rubiaceae)

    OpenAIRE

    Oliveira, Marisa de Cacia; Negri, Giusepina; Salatino, Antônio; Braga, Márcia Regina

    2007-01-01

    In Rubiaceae, anthraquinones and naphthoquinones are secondary metabolites characteristic of the subfamily Rubioideae, in which Rudgea jasminoides is included. Thin-layer chromatography using specific solvent systems and spray reagents indicated the presence of anthraquinones constitutively produced by cell suspension cultures of R. jasminoides. GC/MS analysis detected 1,4-naphthohydroquinone as a product of biosynthesis only after elicitation of the cells with yeast extract (Saccharomyces ce...

  18. Search for supersymmetry with R-parity violating LL.OVHBAR.E couplings at űs=183 GeV

    Czech Academy of Sciences Publication Activity Database

    Abreu, P.; Adam, W.; Adye, T.; Calvi, M.; Holt, P. J.; Mašík, Jiří; Němeček, Stanislav; Řídký, Jan; Vrba, Václav; Zumerle, G.

    2000-01-01

    Roč. 13, - (2000), s. 591-608 ISSN 1434-6044 R&D Projects: GA ČR GA202/99/1362 Institutional research plan: CEZ:AV0Z1010920 Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 5.408, year: 2000

  19. You’ll never walk alone: A cooperação como paradigma explicativo das dinâmicas das equipas desportivas

    Directory of Open Access Journals (Sweden)

    Pedro Lopes de Almeida

    2013-01-01

    Full Text Available El presente artículo tiene como objetivo proporcionar una breve revisión del constructo de la cooperación deportiva, considerando la manifiesta escasez de la literatura en este campo. Además, se pretende presentar los instrumentos disponibles para la evaluación de la cooperación deportiva, así como la investigación realizada hasta la fecha. Finalmente, se trata de presentar algunos estudios que se hallan actualmente en ejecución y los desafíos futuros de esta línea de investigación. En conclusión, se justifica realzar la importancia de continuar en la profundización y la investigación en este ámbito, , dado que la cooperación puede ser considerada como un paradigma alternativo válido para la comprensión de las dinámicas de equipos deportivos, pero que aún necesita más evidencias empíricas y experimentales.

  20. Vanad ja noored koos - kas pereidüll või tülide tallermaa / Tea Raidsalu ; kommenteerinud Meelike Saarna

    Index Scriptorium Estoniae

    Raidsalu, Tea

    2016-01-01

    Mitme põlvkonna kooselamise plussidest ja miinustest. Selgitusi jagavad ka Tallinna Ülikooli Humanitaarteaduste instituudi vanemteadur Marju Kõivupuu ja Tallinna Ülikooli Eesti Demograafia keskuse nooremteadur ja SHARE Eesti projektijuht Tiina Tambaum

  1. "I'll do it when the snow melts": The effects of deadlines and delayed outcomes on rule-governed behavior in preschool children.

    Science.gov (United States)

    Braam, C; Malott, R W

    1990-01-01

    This study examined the control exerted by different types of rules on the behavior of preschool children. Four similar rules were presented to eight, four-year-old children, using a multielement design. The contingencies the rules described varied in the specification of deadlines and in the delays in the delivery of the reinforcers. The results showed (a) rules specifying only response requirements did not reliably control behavior, (b) rules specifying an immediate deadline with the immediate delivery of a reinforcer exerted reliable control, (c) rules specifying an immediate deadline with a one-week delay in the delivery of the reinforcer also exerted reliable control, and (d) rules specifying no deadline with a one-week delay in the delivery of the reinforcer exerted little control. These results suggest that a rule's specification of a deadline is crucial in its control of behavior, but the delay of the reinforcer is of little importance. This latter conclusion further suggests that problems in self-control do not result from delayed outcomes or the inablity to delay gratification, contrary to conventional wisdom.

  2. “I'll do it when the snow melts”: The effects of deadlines and delayed outcomes on rule-governed behavior in preschool children

    OpenAIRE

    Braam, Cassandra; Malott, Richard W.

    1990-01-01

    This study examined the control exerted by different types of rules on the behavior of preschool children. Four similar rules were presented to eight, four-year-old children, using a multielement design. The contingencies the rules described varied in the specification of deadlines and in the delays in the delivery of the reinforcers. The results showed (a) rules specifying only response requirements did not reliably control behavior, (b) rules specifying an immediate deadline with the immedi...

  3. "Don't eat that, you'll get fat!" Exploring how parents and children conceptualise and frame messages about the causes and consequences of obesity.

    Science.gov (United States)

    Thomas, Samantha L; Olds, Timothy; Pettigrew, Simone; Randle, Melanie; Lewis, Sophie

    2014-10-01

    Family interactions about weight and health take place against the backdrop of the wider social discourse relating to the obesity epidemic. Parents (and children) negotiate complex and often contradictory messages in constructing a set of beliefs and practices around obesity and weight management. Despite this, very little research attention has been given to the nature of family-unit discourse on the subject of body weight and it's potential influence on the weight-related behaviours of family members. This includes the broad influence that dominant socio-cultural discourses have on family conceptualisations of weight and health. Using in-depth qualitative interviews with 150 family 'groups' comprised of at least one parent and one child in Victoria and South Australia, we explored how parents and children conceptualise and discuss issues of weight- and health-related lifestyle behaviours. Data were analysed using Attride-Stirling's (2001) thematic network approach. Three thematic clusters emerged from the analysis. First, both parents and children perceived that weight was the primary indicator of health. However, parents focused on the negative physical implications of overweight while children focused on the negative social implications. Second, weight and lifestyle choices were highly moralised. Parents saw it as their responsibility to communicate to children the 'dangers' of fatness. Children reported that parents typically used negatively-framed messages and scare tactics rather than positively-framed messages to encourage healthy behaviours. Third was the perception among parents and children that if you were thin, then eating habits and exercise were less important, and that activity could provide an antidote to food choices. Results suggest that both parents and children are internalising messages relating to obesity and weight management that focus on personal responsibility and blame attribution. These views reflect the broader societal discourse, and their consolidation at the family level is likely to increase their potency and make them resistant to change. Copyright © 2014. Published by Elsevier Ltd.

  4. Pain Assessment in Critically İll Adult Patients: Validity and Reliability Research of the Turkish Version of the Critical-Care Pain Observation Tool

    Directory of Open Access Journals (Sweden)

    Onur Gündoğan

    2016-12-01

    Full Text Available Objective: Critical-Care Pain Observation Tool (CPOT and the Behavioral Pain Scale (BPS are behavioral pain assessment scales for unconscious intensive care unit (ICU patients. The aim is to determine the validation and reliability of the CPOT in Turkish in mechanically ventilated adult ICU patients. Material and Method: This prospective observational cohort study included 50 mechanically ventilated mixed ICU patients who were unable to report pain. CPOT and BPS was translated into Turkish and language validity was performed by ten intensive care specialists. Pain was assessed in the course of painless and painful routine care procedures using the CPOT and the BPS by a resident and an intensivist concomitantly. Tests reliability, interrater reliability, and validity of the CPOT and the BPS were evaluated. Results: The mean age was 57.4 years and the mean APACHE II score was 18.7. A total of 100 assessments were recorded from 50 patients using CPOT and BPS. Scores of CPOT and BPS during the painful procedures were both significantly higher than painless procedures. The agreement between CPOT and BPS during painful and painless stimuli was ranged as; sensitivity 66.7%-90.3%; specificity 89.7%-97.9%; kappa value 0.712-0.892. The agreement between resident and intensivist during painful and painless stimuli was ranged from 97% to 100% and the kappa value was between 0.904 and 1.0. Conclusion: The Turkish version of the CPOT showed good correlation with the BPS. Interrater reliability between resident and intensivist was good. The study showed that the Turkish version of BPS and CPOT are reliable and valid tools to assess pain in daily clinical practice for intubated and unconscious ICU patients who are mechanically ventilated.

  5. Search for heavy resonances decaying into a vector boson and a Higgs boson in the (ll, lnu, nunu) bb final state

    CERN Document Server

    CMS Collaboration

    2016-01-01

    A search for heavy resonances in final states with a Higgs boson and a vector boson, performed using 2.17--2.52 $\\text{fb}^{-1}$ of data collected in 2015 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy $\\sqrt{s}=13\\,\\text{TeV}$, is presented. The leptonic vector boson decays ($\\text{Z} \\to \

  6. “[A]ll comes alive and starts to dance”: The 29th Chapter of Gabriel Josipovici’s Goldberg: Variations

    OpenAIRE

    Jarfe, Günther

    2014-01-01

    Cet article se donne pour objectif de déterminer le sens et la fonction du chapitre 29 de Goldberg: Variations de Gabriel Josipovici. À plusieurs égards, ce chapitre se démarque des autres parties du roman et requiert un commentaire à part. Nous démontrons que ce chapitre reprend le début du roman afin de figurer la joie de l’issue heureuse de la visite de Goldberg. D’une part, la scène de danse prend son sens en relation avec les chapitres ...

  7. “I’ll go down with this ship”: percepções de shippers de Star Wars perante reações negativas no Tumblr

    Directory of Open Access Journals (Sweden)

    Susy Elaine da Costa Freitas

    2016-09-01

    Full Text Available O filme “Star Wars: Episódio VII – O despertar da força” apresentou dois novos personagens à franquia criada originalmente por George Lucas: Rey e Kylo Ren. A dinâmica entre esses antagonistas foi assimilada por parte da comunidade de fãs como uma potencial relação amorosa, o que gerou reações negativas de outra parte do fandom, que viu tal relação como abusiva e o ship, uma apologia ao abuso sexual e outras formas de agressão. O artigo aborda a percepção dos shippers sobre tais reações negativas, o alinhamento de seus discursos contra a acusação e como o shipping abre espaço para discussões de temas para além da obra cultuada pelos fãs a partir da noção de cultura participativa de Henry Jenkins.

  8. Tell Me Where You Are and I’ll Tell You What You Want: Using Location Data to Improve Marketing Decisions

    OpenAIRE

    Spann Martin; Molitor Dominik; Daurer Stephan

    2016-01-01

    Location data has become more and more accessible. Smartphone applications such as location-based services collect location data on a large scale. Up to now, most approaches have relied on past data, but new developments in machine learning and artificial intelligence will soon enable more dynamic real-time use of location data. Companies that embrace these technologies will be able to create competitive advantages. Location data offers great potential to improve a variety of marketing de...

  9. A CONVERSATİON ON INSTRUCTİONAL DESİGN WİTH ROBERT GAGNÉ AND DAVİD MERRİLL NO:1

    OpenAIRE

    Necmi Esgi; Omer Arslan

    2016-01-01

    The purpose of the study is to bring in the first part of diachronic conversation on instructional design with Robert Gagné and David Merrill to transcripts. This conversation was hosted by Utah State University, in the United States of America, in July 10, 1989. Throughout the history of instructional design, these two scientists are considered as the pioneers of the field and in these sessions, they summarize and compare their studies. In the first session, Gagné and Merrill represent their...

  10. ”ja kaiken A ja O olis avoin ja luottamuksellinen yhteistyö” : Varhaiskasvatuspalvelujen täydentäminen varhaiskasvatuksen perhetyöllä

    OpenAIRE

    Kuparinen, Melanie; Ojala, Katja

    2016-01-01

    Opinnäytetyömme tarkoitus oli kehittää varhaiskasvatuksen perhetyön malli Etelä-Suomessa sijaitsevaan kuntaan. Varhaiskasvatuksen perhetyö ei ole uusi palvelumuoto, mutta sille ei ole luotu yksiselitteistä mallia, jota palvelua tarjoavissa kunnissa toteutettaisiin. Pidämme yhteiskunnallisella tasolla tärkeänä tuoda esiin varhaiskasvatuksen perhetyötä ja haluamme kirkastaa sen merkitystä osana perheiden palvelupakettia. Teoriaosuudessa selvitämme lapsiperheiden hyvinvoinnin tilaa ja mi...

  11. ANÁLlSE INSTITUCIONAL DO MECANISMO DE PAGAMENTO POR SERVICOS AMBIENTAIS: o Projeto Conservador das Águas em Extrema - MG

    Directory of Open Access Journals (Sweden)

    Rafael Eduardo Chiodi

    2013-01-01

    Full Text Available Economic incentive mechanisms are being accessed by public policies to promote environmental conservation. The environment services payment is one of these, and in Brazil the Water Conservation Project in Extrema - MG is its prominent case. The paper analyses how the trajectory and inter-institutional relations determinated the existence and development ot this project, considering the advances and limitations ot this case for the mechanlsm's effectiveness. It concludes that the project creation influenced formal and informal institutions and promoted inter-relationships among key- actors and stakeholders which were fundamental to the achieved results . The polítical stability, technical experience, the interest and personal dedication ot its founder, along with a central management were essential aspects to the projsct's existence. However, there are limitations and concerns that the mechanism leads to economic reductionism to deal with complex problems that concerns to the relatlons between society and environment.

  12. “Most likely you go your way and I’ll go mine”: A Rock Star’s Guide to Abandoning your Audience “Most likely you go your way and I’ll go mine”, ou comment abandonner son public lorsqu’on est une star du rock

    Directory of Open Access Journals (Sweden)

    Adrian Smith

    2009-11-01

    Full Text Available L’analyse du roman de Don DeLillo Great Jones Street constituera le fil conducteur de ce travail. Elle nous permettra de confronter la réclusion du personnage de Bucky Wunderlick et la retraite de Bob Dylan dans la maison appelée « Big Pink », à West Saugerties, New York, où l’auteur- compositeur-interprète enregistre avec The Band les fameuses Basement Tapes. À la recherche d’oubli et d’annihilation que motive le retrait de la scène rock protestataire du personnage de DeLillo, nous comparerons la volonté de Dylan et ses musiciens de s’éloigner de l’industrie de la musique pour mieux renouveler leur inspiration en inscrivant leurs morceaux dans l’héritage musical américain. Nous verrons également qu’en s’éloignant du milieu de la musique folk, Dylan, loin d’avoir tourné le dos au radicalisme politique, a poursuivi sa démarche de contestation dans son mode d’expression artistique.

  13. Relações entre o teor de fenóis totais e o ciclo das galhas de Cecidomyiida e em Aspidosperm a spruceanum Müll. Arg. (Apocynaceae Relationships between phenolic contents and a Cecidomyiidae gall cycle in Aspidosperma spruceanum Müll. Arg. (Apocynaceae

    Directory of Open Access Journals (Sweden)

    Anete Teixeira Formiga

    2009-03-01

    Full Text Available Alterações morfológicas detectadas em diversas espécies vegetais em função da indução de galhas são comumente acompanhadas de mudanças químicas importantes para o estabelecimento e manutenção do sistema galhador-planta hospedeira. O estudo da variação do teor de fenóis totais e sua relação com o desenvolvimento das galhas no sistema Aspidosperma spruceanum-Cecidomyiidae foi realizado ao longo de um ano, no qual foram detectados pelo menos dois ciclos de vida dos insetos indutores. O nível de infestação foliar foi alto, atingindo 87%, e os Cecidomyiidae tiveram a região internervural como sítio preferencial de oviposição. A variação sazonal no conteúdo de fenóis totais nas amostras de folhas sadias e galhadas foi primariamente relacionada às condições abióticas e muito embora este teor tenha atingido o máximo de 10 mg EAT g-1, indicando um ambiente químico celular não favorável à indução e a sua sobrevivência, o indutor de A. spruceanum supera esta barreira química, podendo ainda ser favorecido pela proteção contra inimigos naturais propiciada pelos fenólicos.Morphological alterations detected in several plant species due to gall induction are commonly followed by chemical changes fundamental to the establishment and maintenance of the host plant-gall maker system. The study of phenolic contents variation and its relation to gall development in Aspidosperma spruceanum-Cecidomyiidae system through a year-time detected two insect life cycles. The level of infestation was high, getting up to 87%, and the Cecidomyiidae preferentially oviposited in internervural region. Seasonal variation in phenolic contents in healthy and galled leaves detected in A. spruceanum was primarily related to abiotic conditions. Even though the levels of phenolic contents might get a maximum of 10 mg EAT g-1, which indicated a non stimulating cell chemical environment to gall induction and herbivore survivorship, A. spruceanum gall maker surpassed this chemical barrier, and might also be favored by the chemical protection against its natural enemies, that phenolic contents might confer.

  14. Fenologia, morfologia floral e visitantes de Psychotria brachypoda (Müll. Arg. Britton (Rubiaceae em uma área de Floresta Atlântica, Sudeste do Brasil Phenology, floral morphology and visitors of Psychotria brachypoda (Müll. Arg. Britton (Rubiaceae in Atlantic Forest, southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Lorena Coutinho Nery Fonseca

    2008-03-01

    Full Text Available No presente estudo foram descritos o padrão fenológico, biologia floral, visitantes florais mais freqüentes e taxa de formação de frutos de Psychotria brachypoda, em uma área de Floresta Atlântica. O padrão de floração foi anual e intermediário, ocorrendo entre agosto e janeiro. A produção de frutos maduros ocorreu de março a julho/2004 e de fevereiro a maio/2005. O comprimento e o diâmetro da corola das flores brevistilas foram maiores que das longistilas. Apesar de não ter havido hercogamia recíproca exata, houve sobreposição entre as alturas dos estigmas das flores longistilas com os estames das brevistilas e vice-versa. O néctar apresentou maior concentração média de açúcares às 06:30 h (33% e menor às 14:30 h (26%. Flores cujo néctar foi coletado ao longo do dia produziram em média três vezes mais néctar que as flores que tiveram o néctar coletado apenas no final do dia. Foram encontrados 24 indivíduos brevistilos e 25 longistilos, indicando que a população é isoplética. Os principais visitantes florais foram machos e fêmeas do beija-flor Thalurania glaucopis, abelhas da tribo Trigonini e do gênero Euglossa, três espécies de lepidópteros, um díptero e um coleóptero. Houve formação de frutos verdes em 13,3% do total de flores marcadas e a taxa de produção de frutos foi similar entre os morfotipos florais. É provável que o principal polinizador de P. brachypoda seja o beija-flor T. glaucopis porque ele visita com freqüência muitas flores de diferentes indivíduos, provavelmente transferindo pólen entre eles.In this paper, the phenological pattern, floral biology, most frequent floral visitors and fruit set of Psychotria brachypoda are described. This study was carried out in Atlantic forest from October 2003 to September 2005. Flowering was annual and intermediate, occurring from August to January. Mature fruit production occurred from March to July 2004 and from February to June 2005. Corolla length and diameter of thrum flowers were larger than those of pin flowers. Although stigma length corresponded approximately to stamen length in each morph, exact reciprocal hercogamy did not occur. The nectar was more concentrated at 06:30h (33% and more diluted at 14:30h (26%. Flowers in which nectar was collected throughout the day had about three times more nectar than flowers in which nectar was collected once at the end of the day. There were 24 plants with thrum flowers and 25 plants with pin flowers, indicating an isopletic population. The main floral visitors were females and males of the hummingbird Thalurania glaucopis, bees of the tribe Trigonini and of the genus Euglossa, three Lepidoptera species, one Diptera species and one Coleoptera. Fruit was produced in 13.7% of the total number of marked flowers, with similar production in both morphs. Thalurania glaucopis is probably the most important pollinator of P. brachypoda, because it often visits many flowers from different individuals of P. brachypoda, probably transferring pollen among them.

  15. Análise anatômica qualitativa e quantitativa e densidade básica da madeira de Alchornea sidifolia Müll. Arg. (Euphorbiaceae. Qualitative and quantitative anatomical analysis of the wood of Alchornea sidifolia Müll. Arg. (Euphorbiaceae

    Directory of Open Access Journals (Sweden)

    Luiz SANTINI JUNIOR

    2010-12-01

    Full Text Available Objetivou-se caracterizar a anatomia e densidade básica da madeira de Alchornea sidifolia (tapiá-guaçu, e investigar a variação radial destas características. O material de estudo procede do lote cinco do Rodoanel trecho sul no Estado de São Paulo, onde cinco árvores foram identificadas no campo, retirando-se discos do DAP com média de 30 cm de diâmetro. As análises das amostras seguiram os métodos usualmente empregados em estudo de anatomia de madeiras. A espécie apresentou camadas de crescimento distintas; vasos solitários e múltiplos; placas de perfuração simples; parênquima axial apotraqueal em linhas; raios unisseriados, alternando células quadradas e eretas com inclusões cristalíferas e amido; fibras libriformes, não septadas e gelatinosas; canais radiais; máculas medulares; densidade básica baixa (0,38 g cm-3. Ocorreu aumento no sentido medula-casca apenas para o comprimento das fibras, diâmetro dos vasos e diâmetro das pontoações intervasculares, características que denotam madeira homogênea e de baixa resistência. Fibras com maiores lume estão associadas a menores valores de densidade básica.In this paper, we characterize the anatomy and basic density of wood in Alchornea sidifolia (tapiá-guaçu, and investigate the radial variation of these characteristics. Five trees were cut in the “Rodoanel” section southern in São Paulo state, were removed disks with 30 cm at breast height. Six samples were taken from the pith to bark, which were analyzed according to the usual methods in anatomy and properties of wood. The results revealed the presence of layer growth, solitary and multiples vessels; simple perforation plate; axial parenchyma in lines up three cells wide; rays exclusively uniseriate, all ray cells upright and/or square with inclusions crystals and starch; ground tissue fibers, non-septate and gelatinous; radial canals; pith fleck present; low basic density (0.38 g cm-3. There was an increase in the pith to bark only for the fiber length, vessel diameter and intervessel pits diameter, which features a wood homogeneous and low resistance. Fibers with higher lumen are associated with lower basic density.

  16. Análise anatômica qualitativa e quantitativa e densidade básica da madeira de Alchornea sidifolia Müll. Arg. (Euphorbiaceae). Qualitative and quantitative anatomical analysis of the wood of Alchornea sidifolia Müll. Arg. (Euphorbiaceae)

    OpenAIRE

    Luiz SANTINI JUNIOR; Eduardo Luiz LONGUI; Israel Luiz de LIMA; Osny Tadeu de AGUIAR; Sandra Monteiro Borges FLORSHEIM

    2010-01-01

    Objetivou-se caracterizar a anatomia e densidade básica da madeira de Alchornea sidifolia (tapiá-guaçu), e investigar a variação radial destas características. O material de estudo procede do lote cinco do Rodoanel trecho sul no Estado de São Paulo, onde cinco árvores foram identificadas no campo, retirando-se discos do DAP com média de 30 cm de diâmetro. As análises das amostras seguiram os métodos usualmente empregados em estudo de anatomia de madeiras. A espécie apresentou camadas de cresc...

  17. Effect of self-deflection on a totally asymmetric simple exclusion process with functions of site assignments

    Science.gov (United States)

    Tsuzuki, Satori; Yanagisawa, Daichi; Nishinari, Katsuhiro

    2018-04-01

    This study proposes a model of a totally asymmetric simple exclusion process on a single-channel lane with functions of site assignments along the pit lane. The system model attempts to insert a new particle to the leftmost site at a certain probability by randomly selecting one of the empty sites in the pit lane, and reserving it for the particle. Thereafter, the particle is directed to stop at the site only once during its travel. Recently, the system was determined to show a self-deflection effect, in which the site usage distribution biases spontaneously toward the leftmost site, and the throughput becomes maximum when the site usage distribution is slightly biased to the rightmost site. Our exact analysis describes this deflection effect and show a good agreement with simulations.

  18. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (76th, Kansas City, Missouri, August ll-l4, l993). Part XI: Advertising.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Advertising section of this collection of conference presentations contains the following 12 papers: "How Leading Advertising Agencies Perceive and Use Barter Syndication: A Pilot Study" (Sylvia M. Chan-Olmsted); "Three Giants--Leo Burnett, David Ogilvy, William Bernbach: An Exploration of the Impact of the Founders' Written…

  19. If you like low P/sub T/ multiparticle physics, you'll love nucleus-nucleus interactions or Do E/sub T/ distributions obey KNO scaling in high energy pp and nucleus-nucleus collisions

    International Nuclear Information System (INIS)

    Tannenbaum, M.J.

    1985-01-01

    Measurements of neutral transverse energy spectra in p-p, d-d and α-α interactions at the CERN ISR are presented. The source of transverse energy is the emission of relatively low P/sub T/ particles distributed uniformly. Analysis of the αα data in terms of multiple nucleon-nucleon collisions is most convenient when Gamma distributions are used to represent the spectral shapes. This distribution bears a strong relationship to the Negative Binomial Distribution which describes multiplicity distributions in pp and p anti p interactions over the full available energy range. Extensive analysis of the data is presented in terms of Nuclear Models. However, the best fit to the pp and αα data is a single Gamma distribution scaled by the mean value. This property is also known as KNO scaling. 15 refs., 2 figs

  20. NOPS 2010–2012 –hanke, Nuoren työ- ja toimintakyvyn edistäminen ammattiopistoissa : Ammattiopiston opiskelijan terveysosaaminen terveystapahtumien jälkeen : Terveystapahtumien toteutuminen ammattiopistoissa keväällä 2011

    OpenAIRE

    Javanainen, Jonna; Leino, Maria; Kahri, Vesa

    2012-01-01

    Tämä opinnäytetyö on osa NOPS 2010–2012 -hankkeesta (Nuoren työ- ja toimintakyvyn edistäminen ammattiopistoissa). NOPS 2010–2012 -hankkeen tarkoituksena on luoda nuoren työ- ja toimintakykyä edistävä toimintamalli, jossa ammattikorkeakoulun opiskelijat kytketään osaksi ammattiopistojen terveyttä edistävää työtä. Hankkeessa kehitetään myös sellaisia terveyden edistämisen menetelmiä, jotka soveltuvat ammattiopistossa opiskelevien nuorten työ- ja toimintakyvyn edistämiseen. Hankkeessa tehdä...

  1. Avaliação sazonal da produção de borracha e da dinâmica de carboidratos solúveis em plantas de seringueira (Heveabrasiliensis Müll. Arg. cultivadas em Lavras, Minas Gerais

    Directory of Open Access Journals (Sweden)

    Lima Denis Ubeda de

    2002-01-01

    Full Text Available O objetivo deste trabalho foi avaliar a produção de látex de seringueira (Heveabrasiliensis e as possíveis alterações no teor de carboidratos em função das variações de fatores climáticos. Foram utilizadas plantas do clone RRIM 600 com 8 anos de idade e no primeiro ano de exploração. As análises dos teores de açúcares solúveis totais e açúcares redutores foram realizadas em duas datas distintas, 29/8/97 (inverno e 23/12/97 (verão, com amostragens em intervalos de 3 horas, em um ciclo de 24 horas de avaliação. A produção de borracha seca foi avaliada em duas sangrias, em cada estação. Os resultados evidenciaram que, além da relação da produção de borracha com a disponibilidade de água, as variações de temperatura entre as estações também tiveram uma importante influência sobre a disponibilidade de carboidratos para a síntese de látex.

  2. Televiisorit kaissu ei võta, kuid raamatut küll : raamatupoe letilt võib leida mitte lihtsalt häid, vaid lausa suurepäraseid lasteraamatuid / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2001-01-01

    Sisu : Lloyd Alexander. Llyri loss; Lloyd Alexander. Rändur Taran; Skomantas. Teutoonide vang. Lühidalt ka Otfried Preussleri, Thorbjırn Egneri, Vitezlav Nezvali, Jỉi Trnka, Aino Perviku ja Ellen Niidu raamatutest

  3. Lactobacillus bulgaricus Fajlarının Restriksiyon Fragment Uzunluk Polimorfizmi, Protein Profilleri ve Konakçı Özgüllüklerine Göre Tanımlanması

    Directory of Open Access Journals (Sweden)

    Esra Acar Soykut

    2015-02-01

    Full Text Available Lactobacillus delbrueckii subsp. bulgaricus suşlarına etkili 19 adet faj, restriksiyon fragment uzunluk polimorfizmi (RFLP, yapısal protein şablonları ve konakçı spektrumlarına göre tanımlanmış ve sınıflandırılmıştır. Fajlar, farklı süt ürünlerinden L. bulgaricus starter kültürleri (Y4, V1 ve V2 ile izole edilmiştir. Konakçı spektrumunun belirlenmesi için; doğal ve ticari L. bulgaricus suşlarının L. bulgaricus V1 ve V2 fajları ile S. thermophilus B3 fajlarına duyarlılıkları test edilmiştir. Doğal L. bulgaricus suşlarının tamamının, L. bulgaricus fajlarının hepsine duyarlılık gösterdiği tespit edilmiştir. Bununla birlikte bazı doğal L. bulgaricus suşlarının, S. thermophilus fajlarına duyarlı olduğu ve heterolog konakçı görevi gördüğü anlaşılmıştır. Çalışılan bu L. bulgaricus fajlarının yapısal protein profilleri ortaya çıkarılmış, fajların iki veya üç major (29.6, 29.2, 26.2 kDa ve ortak olan üç minor (100.8, 65, 50 kDa yapısal proteine sahip oldukları tespit edilmiştir. Bu fajlara ait DNA’lar Eco RI, Pvu II, HindIII, Hha I ve Bam HI restriksiyon enzimleri ile kesime alınmıştır. Oluşan fragmentler doğrultusunda fajlar gruplara ayrılmıştır. Kesim sonucu oluşan fragmentlerin toplamından faj genom büyüklüklerinin 29–34 kb arasında olduğu tespit edilmiştir.

  4. Kesici Delici Alet Yaralanması ile İlişkili Saldırıların Analizi Manisa’da On Yıllık Deneyim

    Directory of Open Access Journals (Sweden)

    Mehmet Sunay Yavuz

    2011-08-01

    Full Text Available Kişilerarası şiddet ile ilişkili olarak kesici-delici alet yaraları halen dünyanın pek çok ülkesinde başlıca problemlerden biri olarak kabul edilmesine rağmen, Türkiye'de sıklığı henüz belirlenmemiştir. Bu çalışmamn amaçları; kesici-delici alet yaralanmaları ile ilişkili saldırıların, mağdur ve faillerin analizini yapmak; daha önce yayımlanmış veriler ile karşılaştırmak ve Türkiye için ııygun önlemleri tanımlamaktır ve bu amaçla 238 kesici-delici alet saldırısı olgusu, 2002 ve 2012 arasında Celal Bayar Üniversitesi Hastanesi Adli Tıp Polikliniği'nde değerlendirilmiştir. Mağdurların ve saldırganların çoğu erkekti (%94.5; %96.5ve 20-39 yaş aralığında idi (%60.1; %67.3. Kesici-delici alet yaralarının büyük bölümü bıçak ve çakılar ile oluşturulmuştu (%81. Saldırılar çoğunlukla caddelerde (%40.3 ve halka açık alanlarda (%36.2 ve gece saatlerinde (%3 1.1 meydana gelmişti. Yaralanmaların çoğu yumuşak doku yaralanmaları (%73.8 idi ve genellikle intratorasik organlar ve/veya damarlar (%40.8 etkilenmişti. Mağdurların %37,4'ü yaşamsal tehl ikeye, %21 'i çeşitli sekellere manız kalmıştı. Suç önleme çabalan bağlamında, kesici-delici alet ile saldırılann gerçek çözümünde; eğitsel, sosyo-kültürel ve ekonomik çabaların yanı sıra; bıçak taşımaya karşı mevzuatın yürürlüğe konulması ve özellikle geceleri olmak üzere sokaklarda ve kamuya açık yerlerde polis denetimlerinin arttırılması önem taşımaktadır. Anahtar kelimeler: Şiddet, yaralar, bıçak, suç, adli tıp

  5. Growth and development of true sago palm (Metroxylon sagu Rottbøll) : with special reference to accumulation of starch in the trunk : a study on morphology, genetic variation and ecophysiology, and their implications for cultivation

    NARCIS (Netherlands)

    Schuiling, D.L.

    2009-01-01

    Keywords: Metroxylon sagu, Arecaceae, starch crops, plant growth and development, plant morphology, inflorescence structure, electron microscopy, phenological scale, genetic variation, plant taxonomy, folk taxonomy, ethnobotany, leaf area, leaf area index, starch accumulation, starch distribution,

  6. Comparison of PCT, CRP, D-Dimer, Lactate, TNF-α, IL-1β, IL-6 and lL-10 in Development of Systemic Inflammatory Response Syndrome and Sepsis on Patients with Isolated Head Trauma and Polytrauma

    Directory of Open Access Journals (Sweden)

    Emine Dağlı

    2012-12-01

    Full Text Available Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS, ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis. Material and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the ISS, GCS score and growth rates of SIRS and sepsis were recorded. Results: It was demonstrated that for patients with isolated head trauma, SIRS (80.6%, sepsis (38.9% and mortality values (71.4% were higher and there is a statistically important linear and inverse relationship between ISS and GCS values (p<0.05. During sepsis and SIRS phases, CRP elevated in both groups, whereas PCT only in the polytrauma group. D-Dimer values were investigated high in both groups, but atypically decreased on day 3 in isolated head trauma group. Lactate, TNF-α and, IL-1β were within reference values, IL-6 and IL-10 values were elevated in both groups but were higher in the polytrauma group. Conclusion: Although multiple variations were detected in serum markers of pro-inflamatory and acute phase proteins, we thought that these are inadequate in predicting mortality and complications such as SIRS and sepsis.

  7. It was nice with the brick so now I'll click: The effects of offline and online experience, perceived benefits, and trust on Dutch consumers' online repeat purchase intention

    NARCIS (Netherlands)

    Beldad, Ardion Daroca; Segers, Mariel; Kurosu, Masaaki

    2013-01-01

    The present study investigated the factors influencing Dutch consumers’ intention to continue purchasing from a brick-and-click clothes shop’s online channel after an initial commercial exchange. Results on the online survey with 513 respondents reveal that their repeat online purchase intention is

  8. Analysis of land stability and land-use change processes in the 19–20th centuries: a case study in Gödöllő Hillside, Hungary

    Directory of Open Access Journals (Sweden)

    Demény Krisztina

    2016-12-01

    Full Text Available The manuscript presents land-use change processes based on former military map analyses. Military maps were derived from the 1770s until the 1890s and later from the CORINE Land Cover map. I observed the transition direction of areal distribution of various land uses. Digitalized maps showed 19-20th century land-use conditions; besides them, we created a grouping system which is based on the intensity of land use. We distinguished six land-use types, ranking them according to the anthropogenic influence (1. built-up areas; 2. arable fields; 3. orchards and vineyards; 4. meadows and pastures; 5. forests; 6. wetlands.

  9. “They can’t wipe us out, they can’t lick us. We’ll go on forever pa, ‘cause we’re the people”: Misrepresenting Death in Jim Sheridan’s In America (2003

    Directory of Open Access Journals (Sweden)

    Seán Crosson

    2008-03-01

    Full Text Available This paper will examine the recurring theme of death in Jim Sheridan’s work, with particular focus on his 2003 film In America. This theme also links Sheridan’s work to one of his favourite directors, John Ford, whose work In America alludes to. While exploring the theme of death in Sheridan’s films, and how it connects with the work of Ford, this paper will consider responses to In America, the first film to be (partly shot in New York after the attack on the twin towers, in light of the tragedy of 9/11. It raises questions about the problematic positioning of this film by Sheridan and others not just with respect to the events of that day but also in relation to the 1981 hunger strikes in Northern Ireland. Furthermore, it questions the regressive politics involved in the depiction of the central black character in In America, Mateo, particularly as it relates to this theme of death.

  10. Lactobacillus bulgaricus Fajlarının Restriksiyon Fragment Uzunluk Polimorfizmi, Protein Profilleri ve Konakçı Özgüllüklerine Göre Tanımlanması

    OpenAIRE

    Soykut, Esra Acar; Tunail, Nezihe

    2014-01-01

    Lactobacillus delbrueckii subsp. bulgaricus suşlarına etkili 19 adet faj, restriksiyon fragment uzunluk polimorfizmi (RFLP), yapısal protein şablonları ve konakçı spektrumlarına göre tanımlanmış ve sınıflandırılmıştır. Fajlar, farklı süt ürünlerinden L. bulgaricus starter kültürleri (Y4, V1 ve V2) ile izole edilmiştir. Konakçı spektrumunun belirlenmesi için; doğal ve ticari L. bulgaricus suşlarının L. bulgaricus V1 ve V2 fajları ile S. thermophilus B3 fajlarına duyarlılıkları test edilmiştir....

  11. “If they don’t see happiness in the picture at least they’ll see the black”: Chris Marker’s Sans Soleil and the Lyotardian Sublime

    Directory of Open Access Journals (Sweden)

    Sarah French

    2010-01-01

    Full Text Available

    Abstract (E: This paper examines Chris Marker’s film Sans Soleil in relation to Jean-François Lyotard’s theory of the sublime. Through an analysis of the film’s representation of memory, time and temporality it will argue that Marker’s film effectively “invokes the unpresentable in presentation itself” (Lyotard, 1992: 15.

     

    Abstract (F: Cet article examine le film Sans Soleil de Chris Marker en relation avec la théorie du sublime de Jean-François Lyotard. À travers une analyse de la représentation de la mémoire, du temps et de la temporalité du film, il soutient que le film de Marker invoque d’une manière effective “l’irreprésentable dans la représentation même” (Lyotard, 1992: 15.

  12. El elixir de la teoría monetaria Argentina: Apuesta por el error tipo ll o una pasión desenfrenada por la inflación

    Directory of Open Access Journals (Sweden)

    Javier Gerardo Milei

    2010-04-01

    Full Text Available Se hace una reseña de las distintas medidas y afirmaciones realizadas por el Gobierno contrastadas con el manual de prácticas en materia de política económica. En función de ello, se presenta una colección de cuatro ensayos: (i El Rol de las Reservas en una Economía, (ii Independencia del BCRA y Tasa de Inflación, (iii La Visión Monetarista de la Inflación y (iv La Inflación, un Fenómeno Siempre Monetario.Se concluye que, en el corto plazo, existe “trade-off” entre inflación y desempleo. Una política monetaria activa ejerce efectos reales sobre el nivel de actividad y empleo. El efecto se diluye luego de 5 años. Finalmente para períodos mayores a diez años no queda efecto en la actividad y se traslada a una mayor inflación. 

  13. DETERM INI NG THE FACTORS WH I CH CAN PREVENT RECREAT I ONAL PART ICIPAION OF UNI VERS I TY STUDENTS WHO A TTEND TO THE DEPARTMENTS ACCORDI NG TO SPEC I AL SK I LL EXAMS

    Directory of Open Access Journals (Sweden)

    Ersan TOLUKAN

    2016-07-01

    Full Text Available The a im of this study was to de termine the factors that prevent the students who studies in the Physical Education and Sport, Musical Education and Painting Departments which request aptitude test, from participating into the recreational activities. Population of the research is consti tuted by total 1918 students who were studying at Gazi University in 2009 - 2010 Academic Years in Physical Education and Sport (1205, Musical Education (216 and Art Education Departments (497 which request aptitude test. Totally 498 volunteer participant s constitute the research‟s sample; 221 students from Physical Education and Sport, 116 students from Musical Education and 161 students from Art Education Departments. Working as a data collection tool and a total of 27 items of the six sub - dime nsions "Le isure Barriers Scale " is used.6 subscales of the questionnaire used in the study to test gender differences in the independent samples t - test analysis was conducted based on the results; by gender "individual psychology in" the (p<0.05 were found to be si gnificant differences . In addition, the ANOVA results, according to the welfare level (individual psychology and lack of interest and section variables and leisure difficulty according to their (individual psychology, lack of friends and lack of interest were statistically significant d ifferences that were observed ( p<0.05 . Consequent ly, the "lack of interest", " facilities/ lack of service " and "individual psychology" factor in preventing the individuals to participate in recreational activities has be en determined that the first three ranks.

  14. “Oh! I’m buying this bikini, it’ll fit perfectly when I’ve lost 2 kilos” : a study on how lingerie and swimwear companies influence consumers to buy their products

    OpenAIRE

    Tran, Ngan; Belul, Ebru

    2017-01-01

    Approximately 50% of girls and young women are not satisfied with their bodies. A huge reason for this is the thin body ideal dominating today’s social media. Lingerie and swimwear companies like Victoria’s Secret, Hunkemöller and Triangl uses the thin body ideal in their social media marketing but do not get any consequences for it. Today’s generation Z have been affected a lot from this kind of marketing. The purpose of the study was to understand how it is possible that young women from ge...

  15. A cue or two and I'll trust you: determinants of trust in government organizations in terms of their processing and usage of citizens' personal information disclosed online

    NARCIS (Netherlands)

    Beldad, Ardion Daroca; van der Geest, Thea; de Jong, Menno D.T.; Steehouder, M.F.

    2012-01-01

    This article discusses the results of a large-scale Internet survey (with 1156 respondents) that investigated the cues and factors that could positively influence Dutch Internet users' trust in government organizations in terms of their usage and processing of citizens' personal data. Confidence in

  16. Perceptions of Aggressive Conflicts and Others' Distress in Children with Callous-Unemotional Traits: "I'll Show You Who's Boss, Even If You Suffer and I Get in Trouble"

    Science.gov (United States)

    Pardini, Dustin A.; Byrd, Amy L.

    2012-01-01

    Background: Children with callous-unemotional (CU) traits may have a particularly malevolent view of social conflicts and a pervasive insensitivity to others' distress. The current study examined whether children with CU traits have unique expectations and values regarding the consequences of aggressive conflicts and a ubiquitous lack of concern…

  17. Search for R-parity violating supersymmetry via the LL anti-E couplings lambda(121), lambda(122) or lambda(133) in p anti-p collisions at s**(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, V.M.; Abbott, B.; Abolins, M.; Acharya, B.S.; Adams, M.; Adams, T.; Agelou, M.; Agram, J.-L.; Ahn, S.H.; Ahsan, M.; Alexeev, G.D.; /Buenos Aires U. /Rio de

    2006-05-01

    A search for gaugino pair production with a trilepton signature in the framework of R-parity violating supersymmetry via the couplings {lambda}{sub 121}, {lambda}{sub 122}, or {lambda}{sub 133} is presented. The data, corresponding to an integrated luminosity of L {approx} 360 pb{sup -1}, were collected from April 2002 to August 2004 with the D0 detector at the Fermilab Tevatron Collider, at a center-of-mass energy of {radical}s = 1.96 TeV. This analysis considers final states with three charged leptons with the flavor combinations ee{ell}, {mu}{mu}{ell}, and ee{tau} ({ell} = e or {mu}). No evidence for supersymmetry is found and limits at the 95% confidence level are set on the gaugino pair production cross section and lower bounds on the masses of the lightest neutralino and chargino are derived in two supersymmetric models.

  18. Crescimento e sobrevivência de duas procedências de Aspidosperma polyneuron em plantios experimentais em Bauru, SP. Growth and survival of two provenances of Aspidosperma polyneuron Müll. in experimental plantation, in Bauru, SP.

    Directory of Open Access Journals (Sweden)

    Aida Sanae SATO

    2008-06-01

    Full Text Available A exploração desordenada das matasnativas vem causando o esgotamento davariabilidade genética de muitas espécies de valoreconômico e ambiental. Desde a década de 1960,o Instituto Florestal de São Paulo vem desenvolvendoestudos pioneiros em conservação ex situ dealgumas espécies nativas ameaçadas e de interesseeconômico, como, por exemplo, Aspidospermapolyneuron, visando à conservação, ao melhoramentogenético e ao conhecimento do seu comportamentosilvicultural. Em 1964 foi implantado um experimentocom duas procedências de A. polyneuron: Bauru(SP e Alvorada do Sul (PR, em uma Unidade deConservação do Instituto Florestal, em Bauru/SP.Foi utilizado o delineamento de blocos ao acaso,com nove plantas por parcela, espaçamento 3 x 3 me seis repetições. Em 2006, foram avaliados odiâmetro à altura do peito (DAP, cm, altura total(HT, m, forma do fuste (F, volume cilíndricoindividual (VCi, m3, volume cilíndrico por hectare(VCha, m3 ha-1 e sobrevivência (S, %. Os resultadosdemonstraram que a procedência Bauru apresentoumaior produção volumétrica de madeira por hectare(VCha e que os valores das demais variáveis nãodiferiram estatisticamente entre as duas procedências.As informações obtidas neste estudo sãoimportantes para fornecer subsídios para avaliar aviabilidade de plantios comerciais e experimentaisde A. polyneuron visando à conservação e aomelhoramento genético desta espécie.The disorderly exploitation of nativeforests has caused the depletion of the geneticvariability of many species of economic andenvironmental value. Since the 1960 decade,the Forestry Institute of São Paulo has beendeveloping pioneering studies of ex situconservation of some endangered native treespecies and with economic interests, as for example,Aspidosperma polyneuron aiming the conservation,the tree breeding and the knowledge of thesilvicultural behavior. In 1964 an experiment withtwo provenances was implanted: A. polyneuron,Bauru (SP and A. polyneuron, Alvorada do Sul(PR in a Conservation Unit of the Forest Institute,in Bauru/SP. The trial was established in acomplete randomized block design with nine treesin square plots, spacing 3 x 3 m and with sixreplications. In 2006, the variables were evaluated:diameter at breast height (DBH, cm, total height(HT, m, stem form (SF, individual cylindricalvolume (VCi, m3, cylindrical volume per hectare(VCha, m3 ha-1 and survival (%. The resultsdemonstrated that the Bauru provenance presentedgreater volumetric production of wood per ha andthat the values of the other variable were notsignificantly different between the two provenances.The information of this study are important forsupply subsidies to evaluate the viability ofcommercial and experimental plantation of thisspecies, contributing for the conservation andimprovement for A. polyneuron.

  19. Llàgrimes vora mar. Guerra, postguerra i riuada al Cabanyal (1936-1975 a través de la memòria (Beatriz Santamarina Campos

    Directory of Open Access Journals (Sweden)

    María Teresa Tapada Berteli

    2010-09-01

    Full Text Available El barrio del Cabanyal, declarado Bien de Interés Cultural (BIC en 1993 por la Generalitat Valenciana, queda afectado por el Plan General de Ordenación Urbana de Valencia desde 1988 y por el controvertido Plan Especial de Protección y Reforma Interior (PEPRI del Cabanyal-Canyameral, aprobado en su versión definitiva por la Generalitat Valenciana el 24 de Enero de 2001. El PEPRI tiene como actuación central la continuación de la Avenida Blasco Ibáñez en línea recta perpendicular a la costa hasta el mar, implicando la demolición de un importante volumen de tejido residencial. Pero al sventramento físico, operación de reforma más propia del siglo XIX y de efectos perversos demostrados, le acompaña silenciosa e impunemente una operación de sventramento moral que extirpa de raíz la memoria de las gentes que lo habitan, verdadero patrimonio cultural e histórico del territorio urbano de la ciudad de Valencia.

  20. Crystallization and Identification of the Glycosylated Moieties of Two Isoforms of the Main Allergen Hev b 2 and Preliminary X-ray Analysis of Two Polymorphs of Isoform ll

    Energy Technology Data Exchange (ETDEWEB)

    Fuentes-Silva,D.; Mendoza-Hernandez, G.; Stojanoff, V.; Palomares, L.; Zenteno, E.; Torres-Larios, A.; Rodriguez-Romero, A.

    2007-01-01

    Latex from Hevea brasiliensis contains several allergenic proteins that are involved in type I allergy. One of them is Hev b 2, which is a {beta}-1,3-glucanase enzyme that exists in different isoforms with variable glycosylation content. Two glucanase isoforms were isolated from trees of the GV-42 clone by gel filtration, affinity and ion-exchange chromatography. Isoform I had a carbohydrate content of about 20%, with N-linked N-acetyl-glucosamine, N-acetyl-galactosamine, fucose and galactose residues as the main sugars, while isoform II showed 6% carbohydrate content consisting of N-acetyl-glucosamine, fucose, mannose and xylose. Both isoforms were crystallized by the hanging-drop vapor-diffusion method. Isoform I crystals were grown using 0.2 M trisodium citrate dihydrate, 0.1 M Na HEPES pH 7.5 and 20%(v/v) 2-propanol, but these crystals were not appropriate for data collection. Isoform II crystals were obtained under two conditions and X-ray diffraction data were collected from both. In the first condition (0.2 M trisodium citrate, 0.1 M sodium cacodylate pH 6.5, 30% 2-propanol), crystals belonging to the tetragonal space group P4{sub 1} with unit-cell parameters a = b = 150.17, c = 77.41 {angstrom} were obtained. In the second condition [0.2 M ammonium acetate, 0.1 M trisodium citrate dihydrate pH 5.6, 30%(w/v) polyethylene glycol 4000] the isoform II crystals belonged to the monoclinic space group P2{sub 1}, with unit-cell parameters a = 85.08, b = 89.67, c = 101.80 {angstrom}, {beta}= 113.6{sup o}. Preliminary analysis suggests that there are four molecules of isoform II in both asymmetric units.