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Sample records for ll dio rats

  1. Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats.

    Science.gov (United States)

    Le Foll, Christelle; Dunn-Meynell, Ambrose A; Levin, Barry E

    2015-02-01

    Hypothalamic fatty acid (FA) sensing neurons alter their activity utilizing the FA translocator/receptor, FAT/CD36. Depletion of ventromedial hypothalamus (VMH) CD36 with adeno-associated viral vector expressing CD36 shRNA (AAV CD36 shRNA) leads to redistribution of adipose stores and insulin resistance in outbred rats. This study assessed the requirement of VMH CD36-mediated FA sensing for the regulation of energy and glucose homeostasis in postnatal day 5 (P5) and P21 selectively bred diet-induced obese (DIO) and diet-resistant (DR) rats using VMH AAV CD36 shRNA injections. P5 CD36 depletion altered VMH neuronal FA sensing predominantly in DIO rats. After 10 wk on a 45% fat diet, DIO rats injected with VMH AAV CD36 shRNA at P21 ate more and gained more weight than DIO AAV controls, while DR AAV CD36 shRNA-injected rats gained less weight than DR AAV controls. VMH CD36 depletion increased inguinal fat pad weights and leptin levels in DIO and DR rats. Although DR AAV CD36 shRNA-injected rats became as obese as DIO AAV controls, only DIO control and CD36 depleted rats became insulin-resistant on a 45% fat diet. VMH CD36 depletion stunted linear growth in DIO and DR rats. DIO rats injected with AAV CD36 shRNA at P5 had increased fat mass, mostly due to a 45% increase in subcutaneous fat. They were also insulin-resistant with an associated 71% increase of liver triglycerides. These results demonstrate that VMH CD36-mediated FA sensing is a critical factor in the regulation of energy and glucose homeostasis and fat deposition in DIO and DR rats.

  2. Laxative activities of Mareya micrantha (Benth. Müll. Arg. (Euphorbiaceae leaf aqueous extract in rats

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    Djaman Joseph A

    2010-02-01

    Full Text Available Abstract Background Mareya micrantha (Benth. Müll. Arg. (Euphorbiaceae is a shrub that is commonly used in Côte d'Ivoire (West Africa for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats. Methods Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate while group 3, 4 and 5 were treated with leaf aqueous extract of Mareya micrantha at doses of 100, 200 and 400 mg/kg body weight (b.w., per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of Mareya micrantha and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion. Results Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and polyterpenes. The aqueous extract of Mareya micrantha applied orally (100, 200 and 400 mg/kg; p.o., produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o. was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o. The same doses of the extract (200 and 400 mg/kg, p.o. produced a significant increase (p -, Na+, K+ and Ca2+ in the intestinal fluid (p Conclusions The results showed that the aqueous extract of Mareya micrantha has a significant laxative activity and supports its traditional use in herbal medicine.

  3. Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats.

    Science.gov (United States)

    Hansen, Gitte; Jelsing, Jacob; Vrang, Niels

    2012-02-01

    To validate the gubra DIO-rats as a useful animal model of human obesity. The gubra diet-induced obesity (DIO) rat model was based on male Sprague-Dawley rats with ad libitum access to regular chow and a palatable diet rich in fat and sugar. To evaluate the versatility of the gubra DIO-rats as a valid model of human obesity syndrome, the efficacy of 2 weight loss compounds liraglutide and sibutramine with different mechanisms of action were examined in 7-month-old gubra DIO-rats. Liraglutide (200 μg/kg, sc) was administered bi-daily, and sibutramine (5 mg/kg, po) was administered once daily for 23 d. Both the compounds effectively reduced the food intake, body weight and total fat mass as measured by nuclear magnetic resonance. Whereas the 5-HT reuptake inhibitor/5-HT receptor agonist sibutramine reduced the intake of both chow and the gubra-diet, the GLP-1 analogue liraglutide predominantly reduced the intake of the highly palatable diet, indicating a shift in food preference. Sibutramine lowered the insulin sensitivity index, primarily via reductions in glucose-stimulated insulin secretion. This animal model responds well to 2 weight loss compounds with different mechanisms of action. Moreover, the gubra DIO-rat can be particularly useful for the testing of compounds with potential effects on diet preference.

  4. Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) rats.

    Science.gov (United States)

    Misawa, Eriko; Tanaka, Miyuki; Nabeshima, Kazumi; Nomaguchi, Kouji; Yamada, Muneo; Toida, Tomohiro; Iwatsuki, Keiji

    2012-01-01

    The aim of the present study was to investigate the anti-obesity effects of Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD rats at 7 wk of age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 kcal% fat) diet (HFD) during the experimental period. Four weeks after of HFD-feeding, DIO rats (11 wk of age) were orally administered with two doses of Aloe vera gel powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) and body fat (%) of HFD fed rats were significantly higher than those of StdD-fed rats. Although a modest decrease of body weight (g) was observed with the administration of dried Aloe vera gel powder, both subcutaneous and visceral fat weight (g) and body fat (%) were reduced significantly in Aloe vera gel-treated rats. Serum lipid parameters elevated by HFD were also improved by the Aloe vera gel treatment. The oxygen consumption (VO(2)), an index of energy expenditure, was decreased in HFD-fed rats compared with that in StdD-fed rats. Administration of Aloe vera gel reversed the change in VO(2) in the HFD-fed rats. These results suggest that intake of Aloe vera gel reduced body fat accumulation, in part, by stimulation of energy expenditure. Aloe vera gel might be beneficial for the prevention and improvement of diet-induced obesity.

  5. Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats

    Czech Academy of Sciences Publication Activity Database

    Holubová, Martina; Zemenová, Jana; Mikulášková, Barbora; Panajotová, V.; Stöhr, J.; Haluzík, M.; Kuneš, Jaroslav; Železná, Blanka; Maletínská, Lenka

    2016-01-01

    Roč. 229, č. 2 (2016), s. 85-96 ISSN 0022-0795 R&D Projects: GA ČR(CZ) GA15-08679S; GA TA ČR(CZ) TE01020028 Institutional support: RVO:61388963 Keywords : prolactin-releasing peptide * lipidization * diet-induced obesity * ZDF rats * food intake * rat Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 4.706, year: 2016

  6. Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats

    Czech Academy of Sciences Publication Activity Database

    Holubová, M.; Zemenová, J.; Mikulášková, Barbora; Panajotová, V.; Stöhr, J.; Haluzík, M.; Kuneš, Jaroslav; Železná, B.; Maletínská, L.

    2016-01-01

    Roč. 229, č. 2 (2016), s. 85-96 ISSN 0022-0795 R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GA15-08679S Institutional support: RVO:67985823 Keywords : prolactin-releasing peptide * lipidization * diet-induced obesity * ZDF rats * food intake rat Subject RIV: ED - Physiology Impact factor: 4.706, year: 2016

  7. Novel polymorphisms within the Dlk1-Dio3 imprinted locus in rat: a putative genetic basis for strain-specific allelic gene expression

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    Laura J Sittig

    2012-12-01

    Full Text Available The imprinted iodothyronine deiodinase-III (Dio3 thyroid hormone metabolizing gene exhibits paternal expression in most fetal tissues, yet exhibits aberrant, maternal expression in the hippocampus in F1 offspring of Sprague Dawley (SD x Brown Norway (BN rats. The maternal hippocampal expression is associated with lower Dio3 mRNA levels specifically in the hippocampus. Here, we tested the hypothesis that genetic polymorphisms between the SD and BN parent strains cause this aberrant allelic Dio3 expression and contribute to behavioral sequelae of higher thyroid hormone levels locally in the hippocampus, including anxiety-related behavior. We mapped and sequenced the Dio3 gene and several previously unmapped regions in the Dlk1-Dio3 locus that could regulate imprinting of the Dio3 gene. In the Dio3 promoter we identified four novel polymorphisms between the BN and SD strains. Next we took advantage of the fact that the Long Evans (LE strain exhibits identical polymorphisms as the SD strain in the region 5’ and including the Dio3 gene. By reciprocally crossing LE and BN strains we tested the relationship among Dio3 promoter region polymorphisms and Dio3 mRNA expression in the hippocampus. Aberrant strain-specific hippocampal Dio3 allelic expression replicated in the LE-BN reciprocal crosses, suggesting that hippocampal-specific imprinting of the Dio3 gene is not the result of a unique genetic or epigenetic characteristic of the SD rat strain, or a unique epistatic interaction between SD and BN. To our knowledge no other studies have reported a genetic x epigenetic interaction of genetic origin in the brain.

  8. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

    DEFF Research Database (Denmark)

    Shang, Quan; Saumoy, Monica; Holst, Jens Juul

    2009-01-01

    Bile acid sequestrants have been shown to lower glucose levels in patients with type 2 diabetes. To investigate how colesevelam (CL) HCl improves hyperglycemia, studies were conducted in diet-induced obesity (F-DIO) rats, which develop insulin resistance when fed a high-energy (high fat/high sucr......Bile acid sequestrants have been shown to lower glucose levels in patients with type 2 diabetes. To investigate how colesevelam (CL) HCl improves hyperglycemia, studies were conducted in diet-induced obesity (F-DIO) rats, which develop insulin resistance when fed a high-energy (high fat...

  9. LL-regular grammars

    NARCIS (Netherlands)

    Nijholt, Antinus

    1980-01-01

    Culik II and Cogen introduced the class of LR-regular grammars, an extension of the LR(k) grammars. In this paper we consider an analogous extension of the LL(k) grammars called the LL-regular grammars. The relation of this class of grammars to other classes of grammars will be shown. Any LL-regular

  10. In-office tooth bleaching with 38% hydrogen peroxide promotes moderate/severe pulp inflammation and production of ll-1β, TNF-β, GPX, FGF-2 and osteocalcin in rats.

    Science.gov (United States)

    Silva-Costa, Renata Suellen Galvão da; Ribeiro, Andressa Eveline de Lima; Assunção, Isauremi Vieira de; Araújo Júnior, Raimundo Fernandes de; Araújo, Aurigena Antunes de; Guerra, Gerlane Coelho Bernardo; Borges, Boniek Castillo Dutra

    2018-06-11

    To study the intensity of inflammatory infiltrate and production of interleukin-1β (ll-1β), tumor necrosis factor-β (TNF-β), fibroblast growth factor-2 (FGF-2), glutathione peroxidase (GPX), and osteocalcin in response to in-office tooth bleaching in rats. Twenty male Wistar rats were randomized into four groups (n=5) according to the received treatment (tooth bleaching or no treatment - control) and the period of euthanasia after treatment (24 h or 10 days). We performed tooth bleaching using a 38% hydrogen peroxide gel on maxillary and mandibular incisors. After euthanasia, incisors (20 per group) were processed for histological analysis, immunohistochemistry staining of ll-1β, TNF-β, FGF-2 and GPX and osteocalcin by immunofluorescence. We analyzed data using the Mann-Whitney and Kruskal-Wallis/Dunn tests (p<0.05). The bleached groups presented statistically significant differences regarding the pulp inflammation stage compared with the control groups. Bleached teeth showed moderate/severe inflammatory infiltrate and control groups presented absent inflammatory cells or a negligible number of mononuclear cells (p<0.001) at two times (24 h and 10 days). There was strong staining for ll-1β, TNF-β, and GPX in bleached groups at 24 h and strong staining for ll-1β, TNF-β, GPX and FGF-2 at 10 days. After 10 days of tooth bleaching, the bleached group showed a statistically superior amount of osteocalcin than the other groups (p<0.01). Tooth bleaching with 38% hydrogen peroxide causes severe pulp inflammation, but characteristics of tissue repair after 10 days.

  11. In-office tooth bleaching with 38% hydrogen peroxide promotes moderate/severe pulp inflammation and production of ll-1β, TNF-β, GPX, FGF-2 and osteocalcin in rats

    Directory of Open Access Journals (Sweden)

    Renata Suellen Galvão da Silva-Costa

    2018-06-01

    Full Text Available Abstract Objectives: To study the intensity of inflammatory infiltrate and production of interleukin-1β (ll-1β, tumor necrosis factor-β (TNF-β, fibroblast growth factor-2 (FGF-2, glutathione peroxidase (GPX, and osteocalcin in response to in-office tooth bleaching in rats. Material and Methods: Twenty male Wistar rats were randomized into four groups (n=5 according to the received treatment (tooth bleaching or no treatment - control and the period of euthanasia after treatment (24 h or 10 days. We performed tooth bleaching using a 38% hydrogen peroxide gel on maxillary and mandibular incisors. After euthanasia, incisors (20 per group were processed for histological analysis, immunohistochemistry staining of ll-1β, TNF-β, FGF-2 and GPX and osteocalcin by immunofluorescence. We analyzed data using the Mann-Whitney and Kruskal-Wallis/Dunn tests (p<0.05. Results: The bleached groups presented statistically significant differences regarding the pulp inflammation stage compared with the control groups. Bleached teeth showed moderate/severe inflammatory infiltrate and control groups presented absent inflammatory cells or a negligible number of mononuclear cells (p<0.001 at two times (24 h and 10 days. There was strong staining for ll-1β, TNF-β, and GPX in bleached groups at 24 h and strong staining for ll-1β, TNF-β, GPX and FGF-2 at 10 days. After 10 days of tooth bleaching, the bleached group showed a statistically superior amount of osteocalcin than the other groups (p<0.01. Conclusions: Tooth bleaching with 38% hydrogen peroxide causes severe pulp inflammation, but characteristics of tissue repair after 10 days.

  12. LALR(1) : LL(1) = LR(0) : LL(0)

    NARCIS (Netherlands)

    Kruseman Aretz, F.E.J.; Emde Boas, van P.; Hemker, P.W.; Hoffman, W.; Houwen, van der P.J.; Pfluger, P.R.

    1992-01-01

    It is shown that LL(l) and LALR(l) acceptors can be obtained by restricting the action tables of the corresponding LL(O) and LR(O) acceptors to those entries that are accessed in at least one accepting sequence (of a sentence from the language). It follows that a number of properties that are easily

  13. Unifying LL and LR parsing

    NARCIS (Netherlands)

    W.H.L.M. Pijls (Wim)

    1993-01-01

    textabstractIn parsing theory, LL parsing and LR parsing are regarded to be two distinct methods. In this paper the relation between these methods is clarified.As shown in literature on parsing theory, for every context-free grammar, a so-called non-deterministic LR(0) automaton can be constructed.

  14. Delayed tooth replantation after root surface treatment with sodium hypochlorite and sodium fluoride: histomorphometric analysis in rats Reimplante dentário tardio após o tratamento da superfície radicular com hipoclorito de sódio e fluoreto de sódio: análise histomorfométrica em ratos

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    André Dotto Sottovia

    2006-04-01

    Full Text Available In cases of delayed tooth replantation, non-vital periodontal ligament remnants have been removed with sodium hypochlorite in an attempt to control root resorption. Nevertheless, reports of its irritating potential in contact with the alveolar connective tissue have been described. Therefore, this study evaluated the healing process on delayed replantation of rat teeth, after periodontal ligament removal by different treatment modalities. Twenty-four rats, assigned to 3 groups (n=8, had their upper right incisor extracted and left on the workbench for desiccation during 60 min. Afterwards, the teeth in group I were immersed in saline for 2 min. In group II, root surfaces were scrubbed with gauze soaked in saline for 2 min; and in group III, scrubbing was done with gauze soaked in 1% sodium hypochlorite solution. Thereafter, root surfaces were etched with 37% phosphoric acid and immersed in 2% acidulate-phosphate sodium fluoride solution, at pH 5.5. Root canals were filled with a calcium hydroxide-based paste and the teeth were replanted. The animals were sacrificed 60 days postoperatively and the pieces containing the replanted teeth were processed and paraffin- embedded. Semi-serial transversally sections were obtained from the middle third of the root and stained with hematoxylin and eosin for histomorphometric analysis. Data were analyzed statistically using Kruskal-Wallis and Dunn's tests. The results showed that root structure and cementum extension were more affected by resorption in group III (pEm reimplante dentário tardio, o ligamento periodontal desvitalizado tem sido removido empregando-se o hipoclorito de sódio, buscando o controle da reabsorção radicular. Relatos de efeito irritante no tecido conjuntivo alveolar após o seu uso, têm sido descritos. Isso justificou a realização deste trabalho buscando minimizar esse inconveniente. Para isso 24 ratos, divididos em 3 grupos de 8 animais, tiveram o incisivo superior direito extra

  15. The equivalence problem for LL- and LR-regular grammars

    NARCIS (Netherlands)

    Nijholt, Antinus; Gecsec, F.

    It will be shown that the equivalence problem for LL-regular grammars is decidable. Apart from extending the known result for LL(k) grammar equivalence to LLregular grammar equivalence, we obtain an alternative proof of the decidability of LL(k) equivalence. The equivalence prob]em for LL-regular

  16. From LL-regular to LL(1) grammars: Transformations, covers and parsing

    NARCIS (Netherlands)

    Nijholt, Antinus

    1982-01-01

    In this paper it is shown that it is possible to transform any LL-regular grammar G into an LL(1) grammar G' in such a way that parsing G' is as good as parsing G. That is, a parse of a sentence of grammar G can be obtained with a simple string homomorphism from the parse of a corresponding sentence

  17. Desmielinização e remielinização após múltiplas injeções intramedulares de brometo de etídio em ratos Wistar Demyelination and remyelination after multiple intramedullary injections of ethidium bromide in Wistar rats

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    Cristina Gevehr Fernandes

    1997-09-01

    Full Text Available O modelo de desmielinização do brometo de etídio foi utilizado para estudar a reação do sistema nervoso central frente a múltiplos episódios de desmielinização tóxica. Foram utilizados 27 ratos Wistar, submetidos a 2,3 ou 4 injeções de 1μl de solução 0,1 % de brometo de etídio (19 ratos ou de solução salina 0,9% (8 ratos em diferentes pontos da medula espinhal. Os intervalos entre as injeções variaram de 28 a 42 dias. Dez dias após a última injeção os animais foram perfundidos com glutaraldeído 2,5%. As medulas espinhais foram avaliadas pela macroscopia, microscopia óptica de cortes semifinos e microscopia eletrônica de transmissão. As lesões foram caracterizadas por desmielinização primária focal, com preservação das estruturas vasculares, e variavam em tamanho e características histológicas. Remielinização pode ser observada, ou não, de acordo com o tipo de lesão. Como conseqüência das injeções múltiplas e seqüenciais de brometo de etídio, o sistema nervoso central pareceu modificar sua capacidade de responder a um estímulo inflamatório, mas não variou seu padrão de remielinização.The ethidium bromide model of demyelination has been employed to study the central nervous system response to several episodes of demyelination. Twenty-seven Wistar rats received 2 to 4 intraspinal injections of lμl of either 0.1% ethidium bromide in normal saline (19 rats or saline 0.9% (8 rats in different anatomical locations. The intervals between the injections ranged from 28 to 42 days. Ten days after the last injection all the rats were perfused with 2.5% glutaraldehyde. The spinal sections were evaluated macroscopically and by light and transmission electron microscopy. The lesions were typical of focal primary demyelination with preserved vascular structures and followed by remyelinization and varied in size and histological aspects. After multiple sequential ethidium bromide injections, the central

  18. Silagens de milho inoculadas microbiologicamente em diferentes estádios de maturidade: perdas fermentativas, composição bromatológica e digestibilidade in vitro

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    Carlos Henrique Silveira Rabelo

    2014-02-01

    Full Text Available Objetivou-se com este estudo avaliar as perdas fermentativas, composição bromatológica e digestibilidade in vitro da matéria orgânica de silagens de milho produzidas em diferentes estádios de maturidade, inoculadas microbiologicamente. Aplicaram-se dois inoculantes comerciais nas silagens produzidas nos estádios SLL, 1/3 LL, 1/2 LL, 2/3 LL e CN, permanecendo ainda um tratamento sem inoculação (silagem controle, configurando um esquema fatorial 3x5. A inoculação com BAL resultou em menores perdas fermentativas (P=0,0348, ao passo que silagens produzidas com plantas mais secas também apresentam menores perdas de MS (P<0,01. A inoculação das silagens resultou em maiores concentrações de PB nas silagens produzidas nos estádios SLL, 2/3 LL e CN (P=0,0033. O uso do inoculante Maize All® resultou em menor concentração de FDN (P=0,0140 no estádio CN e acréscimo dos coeficientes de DIVMO quando as plantas foram colhidas com 2/3 LL e CN (P=0,0006. As perdas fermentativas diminuem devido à utilização dos inoculantes bacterianos e também em silagens produzidas com plantas mais secas. A aplicação de bactérias ácido-láticas (inoculante Maize All® em silagens de milho produzidas com plantas em estádio de maturidade mais avançado melhora a composição química e digestibilidade in vitro.

  19. CAIs in Semarkona (LL3.0)

    Science.gov (United States)

    Mishra, R. K.; Simon, J. I.; Ross, D. K.; Marhas, K. K.

    2016-01-01

    Calcium, Aluminum-rich inclusions (CAIs) are the first forming solids of the Solar system. Their observed abundance, mean size, and mineralogy vary quite significantly between different groups of chondrites. These differences may reflect the dynamics and distinct cosmochemical conditions present in the region(s) of the protoplanetary disk from which each type likely accreted. Only about 11 such objects have been found in L and LL type while another 57 have been found in H type ordinary chondrites, compared to thousands in carbonaceous chondrites. At issue is whether the rare CAIs contained in ordinary chondrites truly reflect a distinct population from the inclusions commonly found in other chondrite types. Semarkona (LL3.00) (fall, 691 g) is the most pristine chondrite available in our meteorite collection. Here we report petrography and mineralogy of 3 CAIs from Semarkona

  20. 25 Years of the Lesbian Section LL

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    Nataša Sukič

    2013-03-01

    Full Text Available Author describes the beginnings and the history of Škuc LL, the first activist lesbian group in Eastern Europe and former Yugoslavia. Trough projects within the cultural and political domains the group has been fighting against lesbophobia and homophobia for the last 25 years. The group tries to create an inclusive, united and egalitarian society of enlightment ideals. The author mixes personal activist history with a development of a lesbian movement from the first initiative in the alternative society of the 80s in Ljubljana to the situation today.

  1. Efeitos das fontes e níveis de lipídios nas dietas de ratos machos da linhagem wistar (rattus norvegicus sobre frações lipídicas do sangue Effect of source and level of fat in the diet of wistar rats (rattus norvegicus on lipoidal fractions in the serum

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    Cecília Sandra Nunes Morais

    2003-10-01

    Full Text Available Foram estudadas quatro fontes lipídicas (óleo de soja, óleo de canola, azeite de oliva e gordura suína em dois níveis na dieta (7 e 14%, verificando a influência do consumo dessas fontes lipídicas sobre algumas frações lipídicas do sangue de ratos. Assim, oito grupos de ratos machos da linhagem Wistar (Rattus norvegicus foram alimentados ad libitum por 56 dias com oito dietas distintas contendo as fontes e níveis citados de lipídios. As dosagens de colesterol total e triacilgliceróis no soro foram realizadas pelo método colorimétrico/enzimático utilizando "kit" comercial específico. O colesterol em HDL foi determinado por precipitação dos quilomícrons, VLDL e LDL, utilizando também "kit" específico. O aumento de lipídios na dieta para 14% elevou os valores de colesterol total, HDL-colesterol e LDL+VLDL-colesterol séricos, quando a fonte foi a gordura suína. Com 14% de lipídios na dieta, os menores valores de triacilgliceróis séricos foram observados nas fontes lipídicas óleo de soja e canola, com valores de 76,09 e 84,42 mg/dL, respectivamente.Four fat sources (soybean oil, canola oil, olive oil, swine fat were evaluated with regard to their influence, at two levels in the diet (7 and 14%, on some fat fractions in rats' blood. Thus, eight groups of Wistar rat (Rattus norvegicus males were ad libitum fed eight different diets, containing the fat and level reported, for 56 days. The dosages of total serum cholesterol and thriacylglicerols were performed by the colorimetric/enzymatic method utilizing a commercial specific kit. The HDL cholesterol was determined by precipitation of kilomicra (VLDL and LDL by utilizing also a specific kit. The increase of fat in the diet to 14% raised the total cholesterol contents, serum HDL cholesterol and LDL + VLDL cholesterol when the source was swine fat. With 14% of fat in the diet, the lowest values of serum triacylglycerols were found for the fat sources soybean and canola oils

  2. Human cathelicidin LL-37 – Does it influence the homeostatic ...

    Indian Academy of Sciences (India)

    70

    37; pulmonary tuberculosis; schizophrenia. 1. Introduction. Cathelicidins are ..... higher LL-37 levels in the cerebrospinal fluid and serum of children with ... found to be lower in cultured epidermal cells taken from biopsies of diabetic foot ulcers .... Greer A, Zenobia C and Darveau RP 2013 Defensins and LL-37: a review of ...

  3. Hombre, bienaventuranza y Dios en Suma Teológica l-ll, qq. 1-6.

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    Ariadne Pérez Treviño

    2013-11-01

    Full Text Available This article studies the Aquinas' proposal on Summa Theologica I-II, qq-1-6, where he studies how should the final end of the man be and concludes that it should be transcendental in a certain way, but immanent in another and that God is the immanent end; then, he studies the way in which man will get it and he finds out that it requires unity in three ways: unity between body and soul, intelligence and will, and finally, between the man, who is well disposed to contemplation and contemplation itself.

  4. Avaliação do efeito radioprotetor do selenito de sódio no processo de reparação tecidual em ratos Evaluation of the radioprotective effect of sodium selenite in the tissue repair process in rats

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    Fabrício M. Tuji

    2005-09-01

    Full Text Available OBJETIVO: Avaliar a ação radioprotetora do selenito de sódio no processo de reparação tecidual. MATERIAIS E MÉTODOS: Ratos Wistar foram submetidos a procedimento cirúrgico para a realização de ferida na região dorsal. Os animais foram divididos em quatro grupos experimentais: controle, selênio, irradiado e selênio-irradiado. Os grupos selênio e selênio-irradiado receberam 2,0 mg/kg de selenito de sódio, 48 horas após a cirurgia. Os grupos irradiado e selênio-irradiado foram submetidos à irradiação em dose única de 6 Gy, administrada somente nas bordas das feridas. Após 4, 7, 13 e 21 dias do procedimento cirúrgico, os animais foram sacrificados e avaliados por meio de análise morfológica, histoquímica e birrefringência do tecido. RESULTADOS: O aspecto estrutural e morfológico, assim como a qualidade do tecido e sua maturação através da quantidade e disposição dos feixes de fibras colágenas, juntamente com o seu grau de orientação macromolecular, permitiu observar a presença de intenso retardo provocado pela irradiação, bem como o efeito radioprotetor do selenito de sódio no processo de reparação. CONCLUSÃO: Dentro das condições experimentais utilizadas, o selenito de sódio apresentou-se como radioprotetor eficaz, visto que o processo de reparação no grupo selênio-irradiado comportou-se, histologicamente, semelhante ao grupo controle.OBJECTIVE: To evaluate the radioprotective effect of sodium selenite in the tissue repair process. MATERIALS AND METHODS: Male Wistar rats submitted to a surgical procedure to produce a wound in the dorsal region. These animals were then divided in four experimental groups: control, selenium, irradiated and selenium-irradiated. The selenium and selenium-irradiated groups received sodium selenite (2.0 mg/kg, 48 hours after surgery. The irradiated and selenium-irradiated groups received a single dose of 6 Gy, administered only in the borders of the wound. The animals were

  5. Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet

    Directory of Open Access Journals (Sweden)

    Xiaoke Wang

    2012-01-01

    Full Text Available Inflammation has been implicated in the hypothalamic leptin and insulin resistance resulting defective food intake during high fat diet period. To investigate hypothalamic inflammation in dietary induced obesity (DIO and obesity resistant (DIO-R rats, we established rat models of DIO and DIO-R by feeding high fat diet for 10 weeks. Then we switched half of DIO and DIO-R rats to chow food and the other half to high fat diet for the following 8 weeks to explore hypothalamic inflammation response to the low fat diet intervention. Body weight, caloric intake, HOMA-IR, as well as the mRNA expression of hypothalamic TLR4, NF-κB, TNF-α, IL-1β, and IL-6 in DIO/HF rats were significantly increased compared to DIO-R/HF and CF rats, whereas IL-10 mRNA expression was lower in both DIO/HF and DIO-R/HF rats compared with CF rats. Switching to chow food from high fat diet reduced the body weight and improved insulin sensitivity but not affecting the expressions of studied inflammatory genes in DIO rats. Take together, upregulated hypothalamic inflammation may contribute to the overeating and development of obesity susceptibility induced by high fat diet. Switching to chow food had limited role in correcting hypothalamic inflammation in DIO rats during the intervention period.

  6. COPD: When You Learn More, You'll Breathe Better

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues COPD: When You Learn More, You'll Breathe Better ... Trial to Look at Home Oxygen Therapy for COPD The National Heart, Lung, and Blood Institute (NHLBI) ...

  7. Holmium laser lithotripsy (HoLL) of ureteral calculi

    Science.gov (United States)

    Kuntz, Rainer M.; Lehrich, Karin; Fayad, Amr

    2001-05-01

    The effectiveness and side effects of ureteroscopic HoLL of ureteral stones should be evaluated. In 63 patients (17 female, 46 males) a total of 75 stones of 3-20 mm diameter were treated with ureteroscopic HoLL. 18.7 percent of stones were located in the proximal third, 24.0 percent in the middle third and 57.3 percent in the distal third of the ureter. HoLL was performed with small diameter semirigid and flexible ureteroscopes, 220 or 365 nm flexible laser fibers and a holmium:YAG laser at a power of 5-15 W (0.5-1.0 J, 10- 15 Hz). 47 of 63 patients (74.6 percent) were immediately free of stones, and 8 others (12.6 percent) lost their residual fragments spontaneously within two weeks. Another 2 patients received additional chmolitholysis for uric acid stone fragments, i.e. 90.5 percent of patients were stone free by one sitting of ureterscopic HoLL. Of the remaining 6 patients (9.5 percent) who still had residual calculi 4 weeks after HoLL, 2 asymptomatic patients refused any additional treatment, 2 patients preferred treatment with ESWL, and 2 patients had a successful second HoLL, thereby raising the success rate of ureteroscopic HoLL to 93.7 percent. 2 patients showed contrast medium extravasation on retrograde ureterograms, due to guide wire perforation. No ureteral stricture occurred. In conclusion, transurethral ureteroscopic HoLL proved to be a safe and successful minimal invasive treatment of ureteral calculi.

  8. Effects of aquatic exercises in a rat model of brainstem demyelination with ethidium bromide on the beam walking test Efeitos de exercícios aquáticos no desempenho motor de ratos submetidos a um modelo de desmielização com brometo de etídio

    Directory of Open Access Journals (Sweden)

    Cíntia Cristina Souza Nassar

    2009-09-01

    Full Text Available Multiple sclerosis is a demyelinating disease of the central nervous system associated with varied levels of disability. The impact of early physiotherapeutic interventions in the disease progression is unknown. We used an experimental model of demyelination with the gliotoxic agent ethidium bromide and early aquatic exercises to evaluate the motor performance of the animals. We quantified the number of footsteps and errors during the beam walking test. The demyelinated animals walked fewer steps with a greater number of errors than the control group. The demyelinated animals that performed aquatic exercises presented a better motor performance than those that did not exercise. Therefore aquatic exercising was beneficial to the motor performance of rats in this experimental model of demyelination.A esclerose múltipla é uma doença desmielinizante do sistema nervoso central que se associa a graus variados de incapacidade. Não se sabe se a realização de intervenções fisioterapêuticas precoces têm impacto na evolução dessa doença. Utilizamos um modelo experimental de desmielinização com o gliotóxico brometo de etídio e a aplicação de exercícios aquáticos precoces para avaliar o desempenho motor dos animais. Foram quantificados o número de passos e os erros executados durante a travessia da barra elevada. Os animais desmielinizados apresentaram menor número de passos e maior quantidade de erros em comparação aos grupos-controle. Os animais desmielinizados que realizaram exercícios aquáticos apresentaram melhor desempenho motor que os animais desmielinizados que não foram submetidos à intervenção. Portanto, a realização de exercícios aquáticos mostrou-se benéfica no desempenho motor dos animais submetidos ao modelo experimental do brometo de etídio.

  9. Reimplante mediato de dentes tratados ou não com solução de hipoclorito de sódio a 1% - estudo histomorfométrico em ratos Effects of sodium hypochlorite on periodontal healing after tooth replantation - histomorphometric study in rats

    Directory of Open Access Journals (Sweden)

    Cláudia Misue KANNO

    2000-06-01

    Full Text Available Foi avaliada a influência do hipoclorito de sódio a 1% no reparo do periodonto de incisivos reimplantados tardiamente em ratos. Os dentes foram mantidos em meio ambiente durante 30 minutos e a seguir imersos em hipoclorito de sódio a 1%, por 25 minutos. Os animais foram sacrificados aos 10, 30 ou 60 dias. Os cortes histológicos foram obtidos no sentido transversal dos terços cervical, médio e apical e delineados com um aumento de 52 vezes. Os eventos observados sobre a superfície radicular foram medidos quanto a sua extensão através de um sistema analisador de imagens (Mini-Mop, Carl Zeiss. Aos 10 dias, observou-se a predominância de tecido conjuntivo fibroso no grupo tratado. Aos 30 e 60 dias observou-se o aumento da anquilose e reabsorção por substituição, assim como neoformação limitada de ligamento periodontal. No grupo controle, aos 30 e 60 dias, foram observadas áreas de reabsorções mais extensas e profundas, quando comparadas ao grupo tratado. Os resultados possibilitaram as seguintes conclusões quando comparado o grupo tratado com o controle: a leva à formação de tecido conjuntivo semelhante a uma cápsula fibrosa no período inicial do reparo; b possibilita uma limitada neoformação de ligamento periodontal; c ocasiona uma superfície de anquilose mais extensa; d não impede a reabsorção por substituição.The aim of the present study was to examine the influence of 1% sodium hypochlorite on periodontal healing after tooth replantation. Rats incisors were extracted, maintained in the environment during 30 minutes, then immersed in 1% sodium hypochlorite for 30 minutes. In the control group, the teeth were maintained in distilled water. The animals were sacrificed after 10, 30 and 60 days. Transversal slices of the teeth were obtained and histologically processed through the hematoxylin and eosin technique. Slices from the cervical, middle and apical thirds of each tooth were selected for the analysis. The

  10. Efeito do lipopolissacarídio bacteriano sobre o esvaziamento gástrico de ratos: avaliação do pré-tratamento com Nw-nitro-L-arginine methyl ester (L-NAME The effect of bacterial lipopolysaccharide on the gastric emptying of rats: a pretreatment evaluation using Nw-nitro-L-arginine methyl ester (L-NAME

    Directory of Open Access Journals (Sweden)

    Edgard Ferro Collares

    2006-09-01

    é-tratados com as mesmas doses do inibidor das óxido nítrico-sintetases e tratados com veículo (40,5% e 38,7%, respectivamente e àqueles pré-tratados com veículo e tratados com a mesma toxina. CONCLUSÃO: O pré-tratamento com Nw-nitro-L-arginine methyl ester numa dose baixa (1 mg/kg determinou redução discreta no efeito de retardo do esvaziamento gástrico determinado pelo lipopolissacarídio in vivo e aumento significativo do retardo com doses mais elevadas (2,5 e 5 mg/kg, doses estas que, per se, não interferem no esvaziamento.BACKGROUND: There is evidence that nitric oxide plays a role in the decrease in gastric emptying induced by bacterial lipopolysaccharide. AIM: To evaluate the effect of pretreatment with Nw-nitro-L-arginine methyl to ester, one competitive inhibitor of the nitric oxide syntases, on the gastric emptying delay induced by lipopolysaccharide. MATERIAL AND METHODS: Male Wistar rats, SPF, were used after 24 h fast and 1 h-water withdrawn. The pretreatment was done intravenously with vehicle (saline or Nw-nitro-L-arginine methyl to ester in the doses of 0.5, 1, 2.5 e 5 mg/kg. After 10 min, the animals were treated iv with lipopolysaccharide (50 mg/kg or received vehicle (saline. The gastric emptying was evaluated 1 h after the lipopolysaccharide administration. A saline solution containing phenol red was used as the test meal. The gastric emptying was indirectly assessed by the determination of percent gastric retention of the test meal 10 min after orogastric administration. RESULTS: The animals pretreated with vehicle and treatment with lipopolysaccharide have significant rise of the gastric retention (average = 57% in comparison with the controls receiving only vehicle (38.1%. The pretreatment with the different doses of Nw-nitro-L-arginine methyl to ester did not modify per se the gastric retention in comparison with the animals pretreated with vehicle. Pretreatment with Nw-nitro-L-arginine methyl to ester with the dose of 1 mg/kg determined a

  11. Homicídio seguido de suicídio na cidade de Porto Alegre

    OpenAIRE

    Sá, Samantha Dubugras; Werlang, Blanca Susana Guevara

    2007-01-01

    O objetivo deste trabalho foi caracterizar o perfil dos indivíduos que cometeram homicídio, seguido de suicídio em Porto Alegre num período de oito anos. As informações sobre esse evento foram localizadas em matérias jornalísticas, inquéritos policiais e entrevistas com informantes. Nos 14 casos localizados, o evento parece ser um fenômeno de gênero, já que os homens são os assassinos/suicidas, e mulheres e crianças, as vitimas. O método mais utilizado para o homicídio e o suicídio foi a arma...

  12. Expression and imprinting of DIO3 and DIO3OS genes in Holstein ...

    Indian Academy of Sciences (India)

    Navya

    2016-10-18

    Oct 18, 2016 ... expressed from the paternal allele, while the DIO3OS transcript is ..... interactions, or via transcriptional occlusion mechanisms (e.g. Kanduri ... The IG-DMR is associated with proper imprinting of linked genes on the maternal.

  13. Expression and imprinting of DIO3 and DIO3OS genes in Holstein ...

    Indian Academy of Sciences (India)

    WENZHI YANG

    type 3 deiodinase, is preferentially expressed from the paternal allele, while ... opposite orientation to DIO3, multiple noncoding and alternatively splicing isoforms from maternal allele. ..... long-range intrachromosomal interactions, or through.

  14. llén’s constant $M$

    CERN Document Server

    Stora, Raymond

    2014-01-01

    In his Handbook Article [1] G. Källén states the asymptotic condition in quantum electrodynamics where the arrow stands for the “weak” asymptotic limit a la LSZ and M is a finite computable constant expressible in terms of the Källén-Lehmann weight function Π(a) for the photon two point function. All the time, there were conflicting points of view between Källén and LSZ, the former insisting on the canonical formulation (which is sick for coupled fields) and the latter who insist on the asymptotic condition. Amusingly enough followers of LSZ in the framework of LSZ assume [2] which turns out to be inconsistent with perturbative renormalizability. Now Källén’s asymptotic condition is perfectly compatible with LSZ since the free vector field A μ in (x) is associated with a reducible representation of the Poincaré group. The best way to sort this out is to look at massive QED (add a mass term to Källén’s Lagrangian in the Handbook Article, see below). The constant M produces in the cano...

  15. Atenção ao Suicídio

    Directory of Open Access Journals (Sweden)

    Berenice Rheinreimer

    2015-11-01

    Full Text Available De acordo com a OMS a cada ano ocorrem 1 milhão de mortes causadas por suicídio, número maior que a soma das mortes causadas por guerras e homicídios (1. Até 2030, as mortes por suicídio podem chegar a 1 milhão e quinhentos mil, caso sejam mantidos os índices de crescimento atuais (2, 3. Para cada morte, ocorrem de 10 a 40 tentativas de suicídio, ou seja, 10 a 40 milhões de tentativas de suicídio ao ano (4.

  16. Effects of sodium hyaluronate and carboxymethylcellulose membrane on collagen and fibroblast formation in bowel suture healing: experimental study in rats Efeitos da membrana de hialuronato de sódio e carboximetilcelulose na formação de colágeno e fibroblastos no processo de cicatrização de colorrafias: estudo experimental em ratos

    Directory of Open Access Journals (Sweden)

    Antônio Carlos Perez

    2005-02-01

    Full Text Available PURPOSE: To analyze the effects of sodium hyaluronate and carboxymethylcellulose membrane on collagen and fibroblast formation in bowel suture healing in rats. METHODS: 48 male Wistar rats, weighing 250 to 343g, were randomized into two groups: group I - bowel suture without applying a biologically absorbable membrane and group II - bowel suture with application of an absorbable membrane. The two groups were divided into subgroups of 3, 14 and 30 days of observation, with 8 rats in each subgroup. All were sacrificed after the end of the observation period. RESULTS: No morbidity or mortality was observed during the experiment. The amounts of collagen in group I were 23.4%, 72.1% and 67.6% and in group II were 22.5%, 52.5% and 51.6%, for the subgroups of 3, 14 and 30 days, respectively. Comparison between groups showed that the 14-day (p=0.0013 and 30-day (p=0.0587 subgroups had significant variance, with larger collagen zones in animals in which the membrane was not applied. However, with regard to fibroblasts, group I had 2%, 13% and 8% and group II had 2%, 10% and 8%, for the 3-day (p=1.0, 14-day (p=0.3184 and 30-day (p=0.5995 subgroups, respectively, showing no significant variance. CONCLUSION: The use of the biologically absorbable membrane cause a decrease in collagen formation, while not altering the number of fibroblasts, in bowel suture healing in rats, without increased morbidity and mortality.OBJETIVO: Analisar os efeitos da membrana de hialuronato de sódio e carboximetilcelulose, na formação de colágeno e fibroblastos na colorrafia de ratos. MÉTODOS: Foram utilizados 48 ratos machos da linhagem Wistar, com peso entre 250 e 343g, distribuídos em dois grupos: grupo I colorrafia sem aplicação de membrana bioabsorvível e grupo II colorrafia com aplicação de membrana bioabsorvível; tendo sido divididos em subgrupos de 3, 14 e 30 dias de observação, com 8 animais em cada um dos subgrupos, todos submetidos à eutanásia após o

  17. Solving L-L Extraction Problems with Excel Spreadsheet

    Science.gov (United States)

    Teppaitoon, Wittaya

    2016-01-01

    This work aims to demonstrate the use of Excel spreadsheets for solving L-L extraction problems. The key to solving the problems successfully is to be able to determine a tie line on the ternary diagram where the calculation must be carried out. This enables the reader to analyze the extraction process starting with a simple operation, the…

  18. The equivalence problem for LL- and LR-regular grammars

    NARCIS (Netherlands)

    Nijholt, Antinus

    1982-01-01

    The equivalence problem for context-free grammars is "given two arbitrary grammars, do they generate the same language?" Since this is undecidable in general, attention has been restricted to decidable subclasses of the context-free grammars. For example, the classes of LL(k) grammars and real-time

  19. Noble Gases in the Hamlet Meteorite (LL4)

    Science.gov (United States)

    Amari, S.; Sabe, Y.; Shiraishi, T.; Matsuda, J.

    2014-09-01

    We analyzed noble gases in a bulk sample and an HF-HCl residue of Hamlet (LL4). The Xe composition of the residue shows that no diamond is contained in the residue. The 20Ne/22Ne ratio of Hamlet Ne-Q has been determined to be 11.0 ± 0.5.

  20. Biodistribution of the radiophamarceutical sodium pertechnetate (Na99mTcO4 after massive small bowel resection in rats Biodistribuição do radiofármaco pertecnetato de sódio (Na99mTcO4 em ratos submetidos a ressecção extensa de intestino delgado

    Directory of Open Access Journals (Sweden)

    Dâmaso de Araújo Chacon

    2007-12-01

    Full Text Available PURPOSE: To evaluate the biodistribution of sodium pertecnetate (Na99mTcO4 in organs and tissues, the morphometry of remnant intestinal mucosa and ponderal evolution in rats subjected to massive resection of the small intestine. METHODS: Twenty-one Wistar rats were randomly divided into three groups of 7 animals each. The short bowel (SB group was subjected to massive resection of the small intestine; the control group (C rats were not operated on, and soft intestinal handling was performed in sham rats. The animals were weighed weekly. On the 30th postoperative day, 0.l mL of Na99mTcO4, with mean activity of 0.66 MBq was injected intravenously into the orbital plexus. After 30 minutes, the rats were killed with an overdose of anesthetic, and fragments of the liver, spleen, pancreas, stomach, duodenum, small intestine, thyroid, lung, heart, kidney, bladder, muscle, femur and brain were harvested. The biopsies were washed with 0.9% NaCl.,The radioactivity was counted using Gama Counter WizardTM 1470, PerkinElmer. The percentage of radioactivity per gram of tissue (%ATI/g was calculated. Biopsies of the remaining jejunum were analysed by HE staining to obtain mucosal thickness. Analysis of variance (ANOVA and the Tukey test for multiple comparisons were used, considering p0.05. An increase in the weight of the SB rats was observed after the second postoperative week. The jejunal mucosal thickness of the SB rats was significantly greater than that of C and sham rats (pOBJETIVO: Avaliar em modelo animal com ressecção extensa do intestino delgado a biodistribuição de pertecnetato de sódio (Na99mTcO4 em órgãos e tecidos, a evolução ponderal e a morfometria da mucosa do intestino delgado remanescente. MÉTODOS: Vinte e um ratos Wistar foram aleatoriamente divididos em três grupos de sete animais cada. O grupo intestino curto (IC foi submetido a ressecção extensa do intestino delgado, o grupo controle (C não foi operado e o grupo sham foi

  1. Assédio moral e assédio sexual: noções distintivas.

    OpenAIRE

    Oliveira, Antonio Luzia Alves de

    2012-01-01

    O autor apresenta as formas de assédios moral e sexual dando ênfases às distinções existentes entre estas práticas, que apesar de muito debatidas e comentadas, ainda são objetos de muitas dúvidas e complexidades na aplicação do Direito a casos concretos.

  2. A Case Study of I’ll Be Fine

    Directory of Open Access Journals (Sweden)

    Angela Ferraiolo

    2017-04-01

    Full Text Available This case study of I’ll Be Fine describes my creation of a passively interactive, “playable” movie for networked screens, and outlines reasons why this story is an instance of a new genre of storytelling that might be called “playable narrative”. Although the piece is interactive, and while it seems to satisfy certain features of the activity of play, I’ll Be Fine does not offer opportunities for strategy, competition, or closure, and does not proceed towards goals or outcomes, but seeks to construct meaning cinematically, proceeding sequentially across planes or layers, and using a spatial design much like the cinematic compositional scheme of background, middle ground, and foreground. While a general model for the spatial construction of playable movies is outside the scope of this writing, the following description of my design concepts are meant to delineate certain aspects of working with spatiality and playability while constructing an interactive story.

  3. Markkinointiviestintä Venäjällä

    OpenAIRE

    Rajalin, Nigina

    2014-01-01

    Tämän opinnäytetyön tavoitteena on selvittää markkinointiviestintää Venäjällä, jotta suomalaiset pienyritykset osaisivat tehokkaasti ja tuloksellisesti markkinoida itseään. Opinnäytetyössä selvitetään Venäjän markkinoiden tilannetta ja tehokkaita markkinointiviestinnän keinoja Venäjällä. Opinnäytetyössä tehdään yleiskatsaus Venäjän talouteen ja sen nykytilaan. Työssä perehdytään Venäjän kulttuuriin ja sen vaikutuksiin markkinointiviestinnässä. Työ on jaettu kahteen teoriaosaan. Ensimmäises...

  4. M4SF-17LL010301071: Thermodynamic Database Development

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Institute, Physical & Life Sciences; Wolery, T. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Akima Infrastructure Services, LLC

    2017-09-05

    This progress report (Level 4 Milestone Number M4SF-17LL010301071) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Argillite Disposal R&D Work Package Number M4SF-17LL01030107. The DR Argillite Disposal R&D control account is focused on the evaluation of important processes in the analysis of disposal design concepts and related materials for nuclear fuel disposal in clay-bearing repository media. The objectives of this work package are to develop model tools for evaluating impacts of THMC process on long-term disposal of spent fuel in argillite rocks, and to establish the scientific basis for high thermal limits. This work is contributing to the GDSA model activities to identify gaps, develop process models, provide parameter feeds and support requirements providing the capability for a robust repository performance assessment model by 2020.

  5. Gottlieb Bindesbøll and Romantic Historicism

    DEFF Research Database (Denmark)

    Kristensen, Peter Thule

    2013-01-01

    The article demonstrates how the Danish architect Gottlieb Bindesbøll (1800-1856) employed a form of repetition of motifs many places in his architecture, regardless of style. A closer look shows that this is not only a distinctive feature of a single architect's work, but also a new way...... of achieving consistency. This design principle emerged in the romantic view of architecture as an organic entity and later became influential among twentieth-century Danish architects....

  6. Efeitos da farinha de folhas de mandioca sobre a atividade das enzimas AST, ALT, FA e lipídios hepáticos de ratos Wistar Effects of cassava leaves flour on the AST, ALT, ALP enzymes activity and hepatic lipids of Wistar rats

    Directory of Open Access Journals (Sweden)

    Daniela Séfora de Melo

    2008-12-01

    Full Text Available Folhas de mandioca possuem substâncias como ligninas e saponinas que podem apresentar efeito hipolipidêmico. Todavia, um estudo recente relatou aumento no peso do fígado de ratos alimentados com dietas contendo farinha de folhas de mandioca (FFM - Manihot esculenta Crantz cv. Cacao, tornando-se necessário um estudo mais aprofundado dos efeitos desta farinha sobre os parâmetros hepáticos. Para este estudo, um ensaio biológico com 32 ratos machos Wistar foi conduzido por um período de 7 semanas, sendo os tratamentos: dieta controle e dietas contendo 5, 10 e 15% de FFM. As dietas contendo FFM não apresentaram efeitos sobre as atividades das enzimas Aspartato Aminotransferase (AST e Fosfatase Alcalina (FA, mas aumentaram significativamente a atividade da enzima alanina aminotransferase (ALT. O estudo histopatológico revelou vacuolização do citoplasma dos hepatócitos para todos os grupos. No entanto, a freqüência de animais com vacuolização acentuada foi superior nos grupos que receberam dietas com FFM, apresentando também maiores teores de lipídios e colesterol total hepáticos e maior relação peso fígado/peso corporal. Estes resultados indicam que os antinutrientes presentes nas folhas de mandioca, como taninos, cianeto e saponinas, podem ser responsáveis pela redução da função hepática nos animais alimentados com FFM.Cassava leaves contain substances such as lignins and saponins that can present the hypolipidemic effect. However, a recent study has reported an increase in liver weight of rats fed diet containing cassava leaves flour (CLF - Manihot esculenta Crantz cv. Cacao. Thus, a further study of the effect of this flour on the hepatic parameters is necessary. For the development of this study, a biological assay with 32 male Wistar rats was conducted for a period of 7 weeks with the following treatments: control diet and diets containing 5, 10, and 15% of CLF. The diets containing CLF showed no effects on the

  7. ¿Dios problemático?

    Directory of Open Access Journals (Sweden)

    García Baró, Miguel

    2002-04-01

    Full Text Available Not available

    El final de la modernidad, ya con dos siglos de historia, es, desde el punto de vista de la religión y su filosofía, sobre todo la gran cuestión abierta de cómo pueda continuar la empresa de la emancipación del hombre después del fracaso del idealismo absoluto y de sus secuelas. Se trata de un tiempo que ha sido comparado con justicia al de una «segunda inocencia», donde importa esencialmente afrontar en toda su amplitud y seriedad el problema del mal y la posibilidad de una esperanza realmente dirigida a la salvación de Dios, y no a cualquier objetivo intramundano.

  8. Stability of the cathelicidin peptide LL-37 in a non-healing wound environment

    DEFF Research Database (Denmark)

    Grönberg, Alvar; Zettergren, Louise; Ågren, Sven Per Magnus

    2011-01-01

    The endogenous cathelicidin peptide LL-37 is strongly expressed at the wound edge early in the process of acute wound healing, but only weakly expressed in chronic wounds. Excessive proteolysis may limit the therapeutic usefulness of exogenous LL-37, especially in ulcers colonized with Pseudomonas...... aeruginosa that produce elastase, which degrades LL-37. This study investigated the stability of synthetic LL-37 against two types of proteinases in the presence or absence of wound fluid samples (diluted to 10-20%) from nine non-healing venous leg ulcers. Incubation of LL-37 (10 µg/ml) at 37°C for 6 h...... resulted in complete degradation by the serine proteinase trypsin (≥ 10 ng/ml), while no degradation was observed with matrix metalloproteinase-9. LL-37 susceptibility to trypsin was diminished considerably in the presence of wound fluid, and there was no apparent cleavage of exogenous LL-37 incubated...

  9. LL-37 induces polymerization and bundling of actin and affects actin structure.

    Directory of Open Access Journals (Sweden)

    Asaf Sol

    Full Text Available Actin exists as a monomer (G-actin which can be polymerized to filaments F-actin that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton. Bundled actin from lysed cells increases the viscosity of sputum in lungs of cystic fibrosis patients. The human host defense peptide LL-37 was previously shown to induce actin bundling and was thus hypothesized to contribute to the pathogenicity of this disease. In this work, interactions between actin and the cationic LL-37 were studied by optical, proteolytic and surface plasmon resonance methods and compared to those obtained with scrambled LL-37 and with the cationic protein lysozyme. We show that LL-37 binds strongly to CaATP-G-actin while scrambled LL-37 does not. While LL-37, at superstoichiometric LL-37/actin concentrations polymerizes MgATP-G-actin, at lower non-polymerizing concentrations LL-37 inhibits actin polymerization by MgCl(2 or NaCl. LL-37 bundles Mg-F-actin filaments both at low and physiological ionic strength when in equimolar or higher concentrations than those of actin. The LL-37 induced bundles are significantly less sensitive to increase in ionic strength than those induced by scrambled LL-37 and lysozyme. LL-37 in concentrations lower than those needed for actin polymerization or bundling, accelerates cleavage of both monomer and polymer actin by subtilisin. Our results indicate that the LL-37-actin interaction is partially electrostatic and partially hydrophobic and that a specific actin binding sequence in the peptide is responsible for the hydrophobic interaction. LL-37-induced bundles, which may contribute to the accumulation of sputum in cystic fibrosis, are dissociated very efficiently by DNase-1 and also by cofilin.

  10. Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

    NARCIS (Netherlands)

    Bomer, N.; Den Hollander, W.T.H.F.; Ramos, Y.F.M.; Bos, S.D.; Van der Breggen, R.; Lakenberg, N.; Pepers, B.A.; Van Eeden, A.E.; Darvishan, A.; Tobi, E.W.; Duijnisveld, B.J.; Van den Akker, E.B.; Heijmans, B.T.; Van Roon-Mom, W.M.C.; Verbeek, F.J.; Osch, G.J.V.M.; Nelissen, R.G.H.H.; Slagboom, P.E.; Meulenbelt, I.

    2015-01-01

    Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by

  11. Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

    NARCIS (Netherlands)

    N. Bomer (Nils); W. den Hollander (Wouter); Y.F.M. Ramos (Yolande); S.D. Bos (Steffan); R. van der Breggen (Ruud); N. Lakenberg (Nico); B.A. Pepers (Barry); A.E. van Eeden (Annelies); A. Darvishan (Arash); E.W. Tobi (Elmar); B.J. Duijnisveld (Bouke); E.B. van den Akker (Erik); B.T. Heijmans (Bastiaan); W.M.C. van Roon-Mom (Willeke); F.J. Verbeek (Fons); G.J.V.M. van Osch (Gerjo); R.G.H.H. Nelissen (Rob); P.E. Slagboom (Eline); I. Meulenbelt (Ingrid)

    2014-01-01

    textabstractObjectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was

  12. Resummed Higgs cross section at N3LL

    International Nuclear Information System (INIS)

    Bonvini, Marco; Marzani, Simone

    2014-05-01

    We present accurate predictions for the inclusive production of a Higgs boson in proton-proton collisions, via gluon-gluon fusion. Our calculation includes next-to-next-to-leading order (NNLO) corrections in perturbative QCD, as well as the resummation of threshold-enhanced contributions to next-to-next-to-next-to-leading logarithmic (N 3 LL) accuracy, with the inclusion of the recently-determined three-loop constant coefficient (sometimes referred to as N 3 LL' accuracy). Our result correctly accounts for finite top, bottom and charm masses at leading order (LO) and next-to-leading order (NLO), and includes the exact top mass dependence at NNLO. At the resummed level the dependence on top, bottom and charm mass is accounted for at NLL, while only the top mass at NNLL. The all-order calculation is improved by a suitable choice of the soft terms, dictated by analyticity conditions and by the inclusion of subleading corrections of collinear origin, which improve the accuracy of the resummation away from the threshold region. We present results for different collider energies and we study perturbative uncertainties by varying renormalization and factorization scales. We find that, at current LHC energies, the resummation corrects the NNLO result by as much as 20 % at μ R =μ F =m H , while the correction is much smaller, 5.5 %, at μ R =μ F =m H /2. While the central value of NNLO+N 3 LL result depends very mildly on the scale choice, we argue that a more realiable estimate of the theoretical uncertainty is found if the perturbative scales are canonically varied about m H .

  13. PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

    Science.gov (United States)

    Chereddy, Kiran Kumar; Her, Charles-Henry; Comune, Michela; Moia, Claudia; Lopes, Alessandra; Porporato, Paolo E; Vanacker, Julie; Lam, Martin C; Steinstraesser, Lars; Sonveaux, Pierre; Zhu, Huijun; Ferreira, Lino S; Vandermeulen, Gaëlle; Préat, Véronique

    2014-11-28

    Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Poly (lactic-co-glycolic acid) (PLGA) supplies lactate that accelerates neovascularization and promotes wound healing. LL37 is an endogenous human host defense peptide that modulates wound healing and angiogenesis and fights infection. Hence, we hypothesized that the administration of LL37 encapsulated in PLGA nanoparticles (PLGA-LL37 NP) promotes wound closure due to the sustained release of both LL37 and lactate. In full thickness excisional wounds, the treatment with PLGA-LL37 NP significantly accelerated wound healing compared to PLGA or LL37 administration alone. PLGA-LL37 NP-treated wounds displayed advanced granulation tissue formation by significant higher collagen deposition, re-epithelialized and neovascularized composition. PLGA-LL37 NP improved angiogenesis, significantly up-regulated IL-6 and VEGFa expression, and modulated the inflammatory wound response. In vitro, PLGA-LL37 NP induced enhanced cell migration but had no effect on the metabolism and proliferation of keratinocytes. It displayed antimicrobial activity on Escherichia coli. In conclusion, we developed a biodegradable drug delivery system that accelerated healing processes due to the combined effects of lactate and LL37 released from the nanoparticles. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. La justicia: ser de Dios y proyecto humano

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Millán Atenciano

    2006-09-01

    Full Text Available Hablar de justicia hoy en teología significa profundizar en las raíces de la palabra, reconocer la bondad de Dios con el hombre, vivir la experiencia del crucificado, sentir la presencia de Dios entre los hombres, conocer el profundo sentido del kerigma pascual... El presente trabajo desea ahondar en un recorrido sintético y trasversal a través de la categoría de justicia en áreas específicas de la teología. Procurando identificar al Dios amor como expresión del Dios justo, un Dios que manifiesta su justicia al hombre hasta identificarse junto a él en lo «totalmente otro». El recorrido de la síntesis pretende responder a una pregunta, en un mundo marcado por la injusticia, en los deseos y anhelos del hombre moderno qué lugar ocupa Dios y realmente estamos ante un Dios justo. En realidad es hacerse eco del cuestionamiento que interroga a Job ¿Puede existir un Dios justo ante la experiencia de sufrimiento que atenaza al hombre? En definitiva se trata de reconocer que la justicia de Dios se manifiesta al hombre a través de nuestra realidad y del mismo modo en una lectura teológica de nuestro momento histórico y sobre todo invitar a perseverar en un mundo de relaciones justas desde nuestra identidad individual para vivir una vida en plenitud y esperanza. De esta forma podemos hacer nuestra la célebre sentencia de la obra del dramaturgo Alemán Bertold Brecht en Madre Coraje, ¡Levantaos cristianos llegó la primavera! algo que podemos hacer extensible a toda la humanidad. Palabras clave: Justicia, Justificación, Hombre nuevo, Plenitud. 

  15. Mis saab ESTERMist? / Tiina Soon, Peeter Päll, Ivi Papstel ; interv. Aili Künstler

    Index Scriptorium Estoniae

    Soon, Tiina

    2008-01-01

    Eesti Õiguskeskuse loodud andmebaasist ESTERM. Vastavad EKI terminoloogiaosakonna juhataja Tiina Soon, EKI keelekorraldusosakonna vanemteadur Peeter Päll, Justiitsministeeriumi avalike suhete talituse juhataja Ivi Papstel

  16. Sisällönhallintajärjestelmä verkkosivuston alustana

    OpenAIRE

    Lehtisaari, Harri

    2013-01-01

    Insinöörityössä selvitettiin avoimen lähdekoodin WordPress-sisällönhallintajärjestelmän soveltuvuutta verkkosivujen alustaksi. Työssä vertailtiin eri sisällönhallintajärjestelmiä asiakkaan toimittamien vaatimusten mukaisesti, minkä pohjalta valittiin soveltuva sisällönhallintajärjestelmä. Soveltuvimmaksi sisällönhallintajärjestelmäksi todettiin WordPress. WordPress asennettiin testipalvelimelle, jolla sivusto rakennettiin ennen sen siirtämistä asiakkaan käyttöön. Insinöörityössä perehdytti...

  17. O Jornalismo nas Rádios Comunitárias

    OpenAIRE

    Rosembach, Cilto José

    2006-01-01

    O presente estudo analisa o jornalismo nas rádios comunitárias a partir do paradigma da comunicação popular, alternativa e da contextualização histórica das rádios comunitárias no Brasil. A programação jornalística de duas rádios comunitárias no Estado de São Paulo é analisada a partir do referencial teórico que elucida a comunicação popular e prioriza os conceitos de jornalismo popular. São analisadas a Rádio Cantareira FM 107,5, de Vila Isabel, distrito de Brasilândia, São...

  18. Empatia e relazione con Dio in Edith Stein

    OpenAIRE

    Betschart, Christof

    2016-01-01

    Introduzione 1. La conoscenza intersoggettiva nella tesi sull’empatia 1.1 L’empatia nella relazione con Dio 1.2 L’empatia né fusione, né separazione 1.3 L’empatia senza mediazione corporea? 2. Scientia Crucis 2.1 L’empatia nella relazione storica con Dio 2.2 L’empatia chiama l’amore 2.3 L’empatia rispetto al Verbo incarnato Conclusione

  19. Rats

    Directory of Open Access Journals (Sweden)

    Alexey Kondrashov

    2012-01-01

    Full Text Available We aimed to perform a chemical analysis of both Alibernet red wine and an alcohol-free Alibernet red wine extract (AWE and to investigate the effects of AWE on nitric oxide and reactive oxygen species production as well as blood pressure development in normotensive Wistar Kyoto (WKY and spontaneously hypertensive rats (SHRs. Total antioxidant capacity together with total phenolic and selected mineral content was measured in wine and AWE. Young 6-week-old male WKY and SHR were treated with AWE (24,2 mg/kg/day for 3 weeks. Total NOS and SOD activities, eNOS and SOD1 protein expressions, and superoxide production were determined in the tissues. Both antioxidant capacity and phenolic content were significantly higher in AWE compared to wine. The AWE increased NOS activity in the left ventricle, aorta, and kidney of SHR, while it did not change NOS activity in WKY rats. Similarly, increased SOD activity in the plasma and left ventricle was observed in SHR only. There were no changes in eNOS and SOD1 expressions. In conclusion, phenolics and minerals included in AWE may contribute directly to increased NOS and SOD activities of SHR. Nevertheless, 3 weeks of AWE treatment failed to affect blood pressure of SHR.

  20. Adsorption Kinetics of Cd(ll and Pb(ll Ions from Aqueous Solutions by Bamboo-Based Activated Charcoal and Bamboo Dust

    Directory of Open Access Journals (Sweden)

    Stevens Azubuike Odoemelam

    2015-01-01

    Full Text Available The use of bamboo dust (BD and bamboo-based activated charcoal for adsorption of Pb(ll and Cd(ll ions from aqueous solutions were assessed in this work. The effect of contact time on the uptake of these metal ions was studied in batch process. The adsorption data were correlated with pseudo first-order, pseudo second-order and diffusivity kinetic models. Results show that pseudo second-order kinetic model gave the best description for the adsorption process. Kinetic studies further showed that the adsorption transport mechanism was particle-diffusion controlled for the adsorption process. Results obtained generally showed that lead(ll ions were better adsorbed onto both adsorbents as compared to cadmium(ll. Comparison of sorption capacity for the two adsorbents shows that bamboo-based activated charcoal exhibited better removal for the metal ions than the bamboo dust.

  1. Effects of conditioned medium from LL-37 treated adipose stem cells on human fibroblast migration.

    Science.gov (United States)

    Yang, Eun-Jung; Bang, Sa-Ik

    2017-07-01

    Adipose stem cell-conditioned medium may promote human dermal fibroblast (HDF) proliferation and migration by activating paracrine peptides during the re-epithelization phase of wound healing. Human antimicrobial peptide LL-37 is upregulated in the skin epithelium as part of the normal response to injury. The effects of conditioned medium (CM) from LL-37 treated adipose stem cells (ASCs) on cutaneous wound healing, including the mediation of fibroblast migration, remain to be elucidated, therefore the aim of the present study was to determine how ASCs would react to an LL-37-rich microenvironment and if CM from LL-37 treated ASCs may influence the migration of HDFs. The present study conducted migration assays with HDFs treated with CM from LL-37 treated ASCs. Expression of CXC chemokine receptor 4 (CXCR4), which controls the recruitment of HDFs, was analyzed at the mRNA and protein levels. To further characterize the stimulatory effects of LL-37 on ASCs, the expression of stromal cell-derived factor-1α (SDF-1α), a CXC chemokine, was investigated. CM from LL-37-treated ASCs induced migration of HDFs in a time- and dose-dependent manner, with a maximum difference in migration observed 24 h following stimulation with LL-37 at a concentration of 10 µg/ml. The HDF migration and the expression of CXCR4 in fibroblasts was markedly increased upon treatment with CM from LL-37-treated ASCs compared with CM from untreated ASCs. SDF-1α expression was markedly increased in CM from LL-37 treated ASCs. It was additionally observed that SDF-1α blockade significantly reduced HDF migration. These findings suggest the feasibility of CM from LL-37-treated ASCs as a potential therapeutic for human dermal fibroblast migration.

  2. OmpA Binding Mediates the Effect of Antimicrobial Peptide LL-37 on Acinetobacter baumannii.

    Directory of Open Access Journals (Sweden)

    Ming-Feng Lin

    Full Text Available Multidrug-resistant Acinetobacter baumannii has recently emerged as an important pathogen in nosocomial infection; thus, effective antimicrobial regimens are urgently needed. Human antimicrobial peptides (AMPs exhibit multiple functions and antimicrobial activities against bacteria and fungi and are proposed to be potential adjuvant therapeutic agents. This study examined the effect of the human cathelicidin-derived AMP LL-37 on A. baumannii and revealed the underlying mode of action. We found that LL-37 killed A. baumannii efficiently and reduced cell motility and adhesion. The bacteria-killing effect of LL-37 on A. baumannii was more efficient compared to other AMPs, including human ß-defensin 3 (hBD3 and histatin 5 (Hst5. Both flow cytometric analysis and immunofluorescence staining showed that LL-37 bound to A. baumannii cells. Moreover, far-western analysis demonstrated that LL-37 could bind to the A. baumannii OmpA (AbOmpA protein. An ELISA assay indicated that biotin-labelled LL-37 (BA-LL37 bound to the AbOmpA74-84 peptide in a dose-dependent manner. Using BA-LL37 as a probe, the ~38 kDa OmpA signal was detected in the wild type but the ompA deletion strain did not show the protein, thereby validating the interaction. Finally, we found that the ompA deletion mutant was more sensitive to LL-37 and decreased cell adhesion by 32% compared to the wild type. However, ompA deletion mutant showed a greatly reduced adhesion defect after LL-37 treatment compared to the wild strain. Taken together, this study provides evidence that LL-37 affects A. baumannii through OmpA binding.

  3. SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice.

    Science.gov (United States)

    Lee, In Hye; Jung, Yu-Jin; Cho, Yong Gu; Nou, Ill Sup; Huq, Md Amdadul; Nogoy, Franz Marielle; Kang, Kwon-Kyoo

    2017-01-01

    Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus. We now demonstrate in this study how signal peptide LL-37 (SP-LL-37) can be used in rice resistance against bacterial leaf blight and blast. We synthesized LL-37 peptide and subcloned in a recombinant pPZP vector with pGD1 as promoter. SP-LL-37 was introduced into rice plants by Agrobacterium mediated transformation. Stable expression of SP-LL-37 in transgenic rice plants was confirmed by RT-PCR and ELISA analyses. Subcellular localization of SP-LL-37-GFP fusion protein showed evidently in intercellular space. Our data on testing for resistance to bacterial leaf blight and blast revealed that the transgenic lines are highly resistant compared to its wildtype. Our results suggest that LL-37 can be further explored to improve wide-spectrum resistance to biotic stress in rice.

  4. Cationic Antimicrobial Peptide LL-37 Is Effective against both Extra- and Intracellular Staphylococcus aureus

    Science.gov (United States)

    Noore, Jabeen; Noore, Adly

    2013-01-01

    The increasing resistance of bacteria to conventional antibiotics and the challenges posed by intracellular bacteria, which may be responsible for chronic and recurrent infections, have driven the need for advanced antimicrobial drugs for effective elimination of both extra- and intracellular pathogens. The purpose of this study was to determine the killing efficacy of cationic antimicrobial peptide LL-37 compared to conventional antibiotics against extra- and intracellular Staphylococcus aureus. Bacterial killing assays and an infection model of osteoblasts and S. aureus were studied to determine the bacterial killing efficacy of LL-37 and conventional antibiotics against extra- and intracellular S. aureus. We found that LL-37 was effective in killing extracellular S. aureus at nanomolar concentrations, while lactoferricin B was effective at micromolar concentrations and doxycycline and cefazolin at millimolar concentrations. LL-37 was surprisingly more effective in killing the clinical strain than in killing an ATCC strain of S. aureus. Moreover, LL-37 was superior to conventional antibiotics in eliminating intracellular S. aureus. The kinetic studies further revealed that LL-37 was fast in eliminating both extra- and intracellular S. aureus. Therefore, LL-37 was shown to be very potent and prompt in eliminating both extra- and intracellular S. aureus and was more effective in killing extra- and intracellular S. aureus than commonly used conventional antibiotics. LL-37 could potentially be used to treat chronic and recurrent infections due to its effectiveness in eliminating not only extracellular but also intracellular pathogens. PMID:23274662

  5. Ch(k) grammars: A characterization of LL(k) languages

    NARCIS (Netherlands)

    Becvar, J.; Nijholt, Antinus; Soisalon-Soininen, E.

    In this paper we introduce the class of so called Ch(k) grammars [pronounced "chain k grammars"]. This class of grammars is properly contained in the class of LR(k) grammars and it properly contains the LL(k) grammars. However, the family of Ch[k) languages coincides with the family of LL(k)

  6. The interaction of antimicrobial peptide LL-37 with artificial biomembranes: epifluorescence and impedance spectroscopy approach

    International Nuclear Information System (INIS)

    Neville, Frances; Cahuzac, Marjolaine; Nelson, Andrew; Gidalevitz, David

    2004-01-01

    Membrane interactions of the human antimicrobial peptide LL-37 have been studied by a variety of techniques including insertion assay, epifluorescence microscopy and impedance spectroscopy. This study makes use of lipid monolayers at the air-aqueous interface to mimic bacterial or eukaryotic membranes. It was found that LL-37 readily inserts into phosphatidylglycerol (PG) and lipid A monolayers, significantly disrupting their structure. In contrast, the structure of phosphatidylcholine (PC) monolayers remains virtually unaffected by LL-37, which is evident both from epifluorescence and electrochemical measurements. Impedance spectroscopy showed that the LL-37 rich PC monolayer remains an ideal capacitor while LL-37 enriched lipid A capacitance decreases significantly, suggesting an increase in layer thickness from peptide-lipid binding

  7. A formulation for the critical temperature T/sub c/ of Ll2-type superconductors

    International Nuclear Information System (INIS)

    Wang Rong-Yao; Zhang Xiao

    1985-01-01

    From the examination of Ll 2 type superconductors, the superconducting critical temperature T/sub b/ of Ll 2 -type superconductors is obtained by: T/sub c/ = 15.9T/sub B/V(B)G/sub A//(√M/sub m/) V(Ll 2 )/sub m/ G/sub B/ where T/sub B/ is the superconducting critical temperature of pure B, V(B) the atomic volume in pure B, V(Ll 2 )/sub m/ the average atomic volume in the Ll 2 type compound, M/sub m/ the average atomic weight of the compound, and G/sub A/, G/sub B/ are the Gordy electronegative values. (author)

  8. LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.

    Science.gov (United States)

    van der Does, Anne M; Beekhuizen, Henry; Ravensbergen, Bep; Vos, Tim; Ottenhoff, Tom H M; van Dissel, Jaap T; Drijfhout, Jan W; Hiemstra, Pieter S; Nibbering, Peter H

    2010-08-01

    The human cathelicidin LL-37 has broad-spectrum antimicrobial activity. It also participates at the interface of innate and adaptive immunity by chemoattracting immune effector cells, modulating the production of a variety of inflammatory mediators by different cell types, and regulating the differentiation of monocytes into dendritic cells. In this study, we investigated the effects of LL-37 on the differentiation of human monocytes into anti-inflammatory macrophages (MPhi-2; driven by M-CSF) versus proinflammatory macrophages (MPhi-1; driven by GM-CSF) as well as on fully differentiated MPhi-1 and MPhi-2. Results revealed that monocytes cultured with M-CSF in the presence of LL-37 resulted in macrophages displaying a proinflammatory signature, namely, low expression of CD163 and little IL-10 and profound IL-12p40 production on LPS stimulation. The effects of LL-37 on M-CSF-driven macrophage differentiation were dose- and time-dependent with maximal effects observed at 10 microg/ml when the peptide was present from the start of the cultures. The peptide enhanced the GM-CSF-driven macrophage differentiation. Exposure of fully differentiated MPhi-2 to LL-37 for 6 d resulted in macrophages that produced less IL-10 and more IL-12p40 on LPS stimulation than control MPhi-2. In contrast, LL-37 had no effect on fully differentiated MPhi-1. Peptide mapping using a set of 16 overlapping 22-mer peptides covering the complete LL-37 sequence revealed that the C-terminal portion of LL-37 is responsible for directing macrophage differentiation. Our results furthermore indicate that the effects of LL-37 on macrophage differentiation required internalization of the peptide. Together, we conclude that LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.

  9. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    Directory of Open Access Journals (Sweden)

    José Germano Ferraz de Arruda

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária.Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  10. Effects of adrenalectomy and constant light on the rat estrous cycle.

    Science.gov (United States)

    Hoffmann, J C

    1978-01-01

    Adult female ARS/Sprague-Dawley rats were allowed to acclimatize to a a lighting schedule of 12L:12D (LD) for 5 weeks. At that time, half the animals were adrenalectomized, and all rats remained in LD for an additional 4 to 5 weeks. Subsequently, half of the control and half of the adrenalectomized rats were exposed to constant light (LL) for an additional 8 weeks, at which time all animals were sacificed. Operated rats with regenerated adrenal tissue, determined either by macroscopic examination or serum corticosterone assay (about 50% of the rats), were excluded from all data calculations. Acute disturbances of estrous cycle length were minor. The long-term effects revealed a significant increase in 5-day cycles among the adrenalectomized rats, although the majority of cycles recorded (80%) were still 4 days in length. None of the rats in LD showed spontaneous persistent estrus. Adrenalectomy did not affect the number of ova shed. When placed in LL, the adrenalectomized rats continued to cycle longer than the unoperated controls, but all rats showed persistent estrus (5 or more consecutive days of vaginal cornification) within 7--8 weeks. Adrenalectomized rats had significantly higher body weights than controls. Relative uterine weight was decreased in these animals in both lighting regimens but only reached statistical significance in LD. Ovarian weight, by contrast, was significantly increased among adrenalectomized rats in LD but was identical in both groups in LL. Adrenal weight of intact rats was not altered by LL. Since estrous cycles can continue for at least 6 months in the absence of the adrenal gland, the persistent estrus that occurs in LL is not merely due to the loss of a diurnal rhythm of corticosteroids. Indeed, when adrenalectomized rats are placed in LL, they continue to show estrous cycles longer than do intact rats. Adrenalectomy does appear to increase the length of the cycle in some animals, and the hormonal basis for this warrants further

  11. Ódio, cúmplice do Eu

    Directory of Open Access Journals (Sweden)

    Maria Neuma Carvalho de Barros

    2013-12-01

    Full Text Available Ingrediente da trama intersubjetiva, o ódio está presente na vida psíquica em circunstâncias diversas e é na situação clínica que revela suas múltiplas faces. Aqui focalizamos a forma positiva com que, na perspectiva psicanalítica, o ódio pode se revestir, como afeto essencial e elemento dinâmico de afirmação do eu. Uma história clínica ilustra essa discussão. O texto ressalta, em suma, a necessidade de ampliar a escuta analítica do ódio, cuja interpretação e manejo devem variar, a depender da vicissitude que assume e de seus propósitos na economia psíquica.

  12. La disyuntiva de Dios: ¿derivadas enteras o fraccionarias?

    Directory of Open Access Journals (Sweden)

    Jorge Fujioka Rojas

    2016-01-01

    Full Text Available Se presentan conceptos básicos del cálculo fraccionario. Para ello, se describe una delas primeras disyuntivas que enfrentó Dios el primer día de la creación: ¿escribiría las leyes físicasen términos de derivadas enteras o fraccionarias? Para salir de esta duda Dios examina lo quepasaría si en la segunda ley de Newton pusiera una derivada fraccionaria, en lugar de la segundaderivada usual. Dios resuelve este problema mediante la transformada de Laplace y esto lo conduceal descubrimiento de la función de Mittag-Leffler.

  13. LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline.

    LENUS (Irish Health Repository)

    Bergsson, Gudmundur

    2009-07-01

    There is an abundance of antimicrobial peptides in cystic fibrosis (CF) lungs. Despite this, individuals with CF are susceptible to microbial colonization and infection. In this study, we investigated the antimicrobial response within the CF lung, focusing on the human cathelicidin LL-37. We demonstrate the presence of the LL-37 precursor, human cathelicidin precursor protein designated 18-kDa cationic antimicrobial protein, in the CF lung along with evidence that it is processed to active LL-37 by proteinase-3. We demonstrate that despite supranormal levels of LL-37, the lung fluid from CF patients exhibits no demonstrable antimicrobial activity. Furthermore Pseudomonas killing by physiological concentrations of exogenous LL-37 is inhibited by CF bronchoalveolar lavage (BAL) fluid due to proteolytic degradation of LL-37 by neutrophil elastase and cathepsin D. The endogenous LL-37 in CF BAL fluid is protected from this proteolysis by interactions with glycosaminoglycans, but while this protects LL-37 from proteolysis it results in inactivation of LL-37 antimicrobial activity. By digesting glycosaminoglycans in CF BAL fluid, endogenous LL-37 is liberated and the antimicrobial properties of CF BAL fluid restored. High sodium concentrations also liberate LL-37 in CF BAL fluid in vitro. This is also seen in vivo in CF sputum where LL-37 is complexed to glycosaminoglycans but is liberated following nebulized hypertonic saline resulting in increased antimicrobial effect. These data suggest glycosaminoglycan-LL-37 complexes to be potential therapeutic targets. Factors that disrupt glycosaminoglycan-LL-37 aggregates promote the antimicrobial effects of LL-37 with the caveat that concomitant administration of antiproteases may be needed to protect the now liberated LL-37 from proteolytic cleavage.

  14. Homicídio, suicídio, morte acidental... 'O que foi que aconteceu?'

    Directory of Open Access Journals (Sweden)

    Klarissa Almeida Silva Platero

    2017-12-01

    Full Text Available O artigo discute as práticas dos profissionais responsáveis por classificar uma morte como “homicídio”, suicídio”, “acidente” ou “morte natural” à luz de abordagens construtivistas que tratam dos processos de criminalização. São analisadas as receitas profissionais utilizadas pelo staff da perícia criminal na tipificação de ocorrências. A pesquisa foi realizada em 2012 com base na observação de 19 “perícias de local do crime” no Rio de Janeiro. Os resultados indicam que as práticas adotadas em casos de morte típicos são diferentes das receitas profissionais seguidas pelo mesmo staff nos casos de morte atípicos. Por isso, o trabalho da perícia parece pouco contribuir para a elucidação da autoria em casos típicos de mortes classificadas como homicídios. Os resultados demonstram a desigualdade social na investigação dos homicídios. The paper Homicide, Suicide, Accidental Death… `What Happened?` discusses state agent’s death classification practices as “homicide”, “suicide”, “accident” or “natural death” in the light of constructionist perspective that deals with criminalization processes. It analyzes officers and coroners’ practical action and practical reasoning and their typifications of the offense and the offender to account for what happened. Ethnographic research was developed based on the observation of nineteen "crime scene investigations" carried out by professionals from the Homicide Division of Rio de Janeiro. The results indicate that the reasoning and practices adopted in typical cases of death are different from the practical recipes followed by the staff in atypical cases of death. For this and others reasons theirs works does little to elucidate authorship in typical and more recurrent cases of deaths classified as homicides in Rio de Janeiro. The results demonstrate the social inequality in the homicide investigation.Keywords: criminal forensics, criminal

  15. Mobbing: assédio moral em contexto de enfermagem

    OpenAIRE

    Carvalho, Guilhermina

    2010-01-01

    Este estudo pretende avaliar o impacto do mobbing (assédio moral ou assédio psicológico) em contexto de enfermagem relativamente à sua frequência, intensidade e efeito. Com isto, pretendeu-se dar visibilidade ao tema, melhor documentá-lo e por conseguinte, melhor compreendê-lo. Um dos objectivos deste trabalho consistiu em traduzir, adaptar e validar uma escala: a LIPT 60 (Leymann Inventory of Psychological Terrorization - versão modificada) a uma população portuguesa de enfermeiros em contex...

  16. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol

    KAUST Repository

    Liu, Xiang; Bastian, Sabine; Snow, Christopher D.; Brustad, Eric M.; Saleski, Tatyana E.; Xu, Jian-He; Meinhold, Peter; Arnold, Frances H.

    2013-01-01

    We have determined the X-ray crystal structures of the NADH-dependent alcohol dehydrogenase LlAdhA from Lactococcus lactis and its laboratory-evolved variant LlAdhA(RE1) at 1.9Å and 2.5Å resolution, respectively. LlAdhA(RE1), which contains three

  17. M4SF-17LL010302072: The Roles of Diffusion and Corrosion in Radionuclide Retardation

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Balboni, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Atkins-Duffin, Cindy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-21

    This progress report (Level 4 Milestone Number M4SF-17LL010302072) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Crystalline Disposal R&D Activity Number M4SF-17LL01030207 and Crystalline International Collaborations Activity Number M4SF-17LL01030208. The focus of this research is the interaction of radionuclides with Engineered Barrier System (EBS) and host rock materials at various physicochemical conditions relevant to subsurface repository environments. They include both chemical and physical processes such as solubility, sorption, and diffusion.

  18. [Psychiatric Hospital San Juan de Dios. One hundred years later].

    Science.gov (United States)

    Cocula-León, Horacio

    2014-01-01

    Mental health and psychiatric diseases have always attracted people's and health authorities' attention due to its magical approach, the lack of knowledge that surrounds them, and, at the same time, the religious fear they provoke. Both have played an important role in the history of humanity, of public health politics, and of physicians. The places where psychiatric patients were treated are of historical interest, because through the historical knowledge we can identify an approach from the science and the health policies that prevailed in each age. At the beginning of the 20th century, it was developed in México a new model of hospital care attention to psychiatric patients. La Casa de Salud San Juan de Dios para Pacientes Alienados is an example; the concept "alienated patients" suggests a social and cultural perspective. This paper presents a chronological type description of one of the major institutions involved in mental health care in México. Similarly, it shows a review of the events that affected the religious order San Juan de Dios from 1901 to 2012, when the hospitaller order was reinstated in México and established the Casa de Salud San Juan de Dios para Pacientes Alienados in the town of Zapopan, Jalisco, institution that exists up to the present day and keeps participating in the mental health care in the state of Jalisco, with the current name of Servicios de Salud San Juan de Dios.

  19. The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.

    Directory of Open Access Journals (Sweden)

    Silke M Currie

    Full Text Available Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions are urgently required. Cathelicidins are cationic host defence peptides expressed in the inflamed lung, with key roles in innate host defence against infection. We demonstrate that the human cathelicidin LL-37 has effective antiviral activity against RSV in vitro, retained by a truncated central peptide fragment. LL-37 prevented virus-induced cell death in epithelial cultures, significantly inhibited the production of new infectious particles and diminished the spread of infection, with antiviral effects directed both against the viral particles and the epithelial cells. LL-37 may represent an important targetable component of innate host defence against RSV infection. Prophylactic modulation of LL-37 expression and/or use of synthetic analogues post-infection may represent future novel strategies against RSV infection.

  20. Spin transfer coefficient DΛLL to Λ hyperon in semi-inclusive DIS at HERMES

    International Nuclear Information System (INIS)

    Belostotski, S; Veretennikov, D; Naryshkin, Yu

    2011-01-01

    Three components of the spin transfer coefficient from the longitudinally polarized electron/positron beam to the Λ or Λ-bar hyperon have been measured in the HERMES experiment. Kinematical dependencies of the spin-transfer have been studied. Averaged over Λ kinematics, longitudinal component of the spin transfer DΛ LL (along the virtual photon direction) to the Λ hyperon is found to be DΛ LL = 0.19 ± 0.04 stat ± 0.02 syst .

  1. Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe): A new radiomics descriptor.

    Science.gov (United States)

    Prasanna, Prateek; Tiwari, Pallavi; Madabhushi, Anant

    2016-11-22

    In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel. The hypothesis behind CoLlAGe is that benign and pathologic phenotypes even though they may appear similar on anatomic imaging, will differ in their local entropy patterns, in turn reflecting subtle local differences in tissue microarchitecture. We demonstrate CoLlAGe's utility in three clinically challenging classification problems: distinguishing (1) radiation necrosis, a benign yet confounding effect of radiation treatment, from recurrent tumors on T1-w MRI in 42 brain tumor patients, (2) different molecular sub-types of breast cancer on DCE-MRI in 65 studies and (3) non-small cell lung cancer (adenocarcinomas) from benign fungal infection (granulomas) on 120 non-contrast CT studies. For each of these classification problems, CoLlAGE in conjunction with a random forest classifier outperformed state of the art radiomic descriptors (Haralick, Gabor, Histogram of Gradient Orientations).

  2. Differential diagnosis of pulmonary emphysema using the CT index: LL%w

    Energy Technology Data Exchange (ETDEWEB)

    Kitahara, Yoshinari; Takamoto, Masahiro; Maruyama, Masao; Tanaka, Yasushi; Ishibashi, Tuneo; Shinoda, Atsushi [Ohmuta National Hospital, Fukuoka (Japan)

    1989-06-01

    We measured the computed tomography (CT) index, LL%w, in 81 patients of chronic obstructive pulmonary disease (COPD) and asthma. In this study we defined LL%w as the mean value of the proportion of the low density area under -950 Hounsfield units in the six lung fields: upper, middle and lower lung fields bilaterally, at deep expiration. To examine the usefulness of LL%w in differentiating pulmomary emphysema (PE) from bronchial asthma (BA) and chronic bronchitis (CB), we excluded the overlapped cases of each disease. Mean value (+- standard deviation) of LL%w in PE was 24.6+-20.2% (n=40), whereas it was 0.5+-0.8% (n=27) in BA and 0.2+-0.3% (n=14) in CB respectively. There were clear statistically differences in the values of LL%w between clinically diagnosed emphysema and others. We considered that the value of LL%w within 1% would be observed nonspecifically, because the frequent existence of low density areas originated in bronchial tangents and/or motion artifacts mainly in the left lower lung field. Thus we judged that cases with over 1% of LL%w had abnormal CT findings. The relationship between clinically diagnosed emphysema and CT abnormality (LL%w > 1%) was significant in the analysis of the four-fold table. The CT sensitivity for diagnosing PE was 100%, the CT specificity was 87.8%, and CT accuracy was 93.8%. When cases of LL%w > 1% were shown in BA or CB, it would be better to consider the existence of complicated emphysema or the presence of air trapping or air spaces of any origin. We compared three groups (A', E', C') selected from groups BA, PE and CB, respectively. The groups consisted of patients showing almost the same mean values of FEV{sub 1.0}/VC(%). The value of the LL%w of E', selected from PE, also showed a significantly higher value than those from BA or CB. (J.P.N).

  3. Differential diagnosis of pulmonary emphysema using the CT index: LL%w

    International Nuclear Information System (INIS)

    Kitahara, Yoshinari; Takamoto, Masahiro; Maruyama, Masao; Tanaka, Yasushi; Ishibashi, Tuneo; Shinoda, Atsushi

    1989-01-01

    We measured the computed tomography (CT) index, LL%w, in 81 patients of chronic obstructive pulmonary disease (COPD) and asthma. In this study we defined LL%w as the mean value of the proportion of the low density area under -950 Hounsfield units in the six lung fields: upper, middle and lower lung fields bilaterally, at deep expiration. To examine the usefulness of LL%w in differentiating pulmomary emphysema (PE) from bronchial asthma (BA) and chronic bronchitis (CB), we excluded the overlapped cases of each disease. Mean value (± standard deviation) of LL%w in PE was 24.6±20.2% (n=40), whereas it was 0.5±0.8% (n=27) in BA and 0.2±0.3% (n=14) in CB respectively. There were clear statistically differences in the values of LL%w between clinically diagnosed emphysema and others. We considered that the value of LL%w within 1% would be observed nonspecifically, because the frequent existence of low density areas originated in bronchial tangents and/or motion artifacts mainly in the left lower lung field. Thus we judged that cases with over 1% of LL%w had abnormal CT findings. The relationship between clinically diagnosed emphysema and CT abnormality (LL%w > 1%) was significant in the analysis of the four-fold table. The CT sensitivity for diagnosing PE was 100%, the CT specificity was 87.8%, and CT accuracy was 93.8%. When cases of LL%w > 1% were shown in BA or CB, it would be better to consider the existence of complicated emphysema or the presence of air trapping or air spaces of any origin. We compared three groups (A', E', C') selected from groups BA, PE and CB, respectively. The groups consisted of patients showing almost the same mean values of FEV 1.0 /VC(%). The value of the LL%w of E', selected from PE, also showed a significantly higher value than those from BA or CB. (J.P.N)

  4. The impact of cathelicidin, the human antimicrobial peptide LL-37 in urinary tract infections.

    Science.gov (United States)

    Babikir, Ibrahim H; Abugroun, Elsir A; Bilal, Naser Eldin; Alghasham, Abdullah Ali; Abdalla, Elmuataz Elmansi; Adam, Ishag

    2018-01-08

    The defense mechanisms of the urinary tract are attributed mainly to the innate immune system and the urinary tract urothelium which represent the first line of defense against invading pathogens and maintaining sterility of the urinary tract. There are only a few publications regarding cathelicidin (LL-37) and a urinary tract infection (UTI). This study was done to investigate the plasma and urine levels of human LL-37 in patients with UTI. A case-control study was conducted at Omdurman Hospital, Sudan during the period from August 2014 to May 2017. The cases were patients with confirmed UTI and the controls were healthy volunteers without UTI. Sociodemographic and clinical data were obtained from each participant using questionnaires. Urine cultures and antimicrobial susceptibility were tested. Plasma and urine levels of LL-37 were determined using an enzyme-linked immunosorbent assay (ELISA) kit. SPSS (version 16.0) was used for analyses. Cases and controls (87 in each arm) were matched according to their basic characteristics. Compared with controls, the median (inter-quartile) LL-37 level in plasma [2.100 (1.700-2.700) vs. 1.800 (1.000-2.200) ng/ml, P = 0.002] and in urine [0.900 (0.300-1.600) vs. 0.000 (0.000-1.000) ng/mg creatinine, P < 0.001] was significantly higher in cases. There was no significant difference in the median plasma [2.1 (1.7-2.9) vs. 2.000 (1.700-2.400) ng/ml, P = 0.561] and urine [0.850 (0.275-2.025) vs. 0.900 (0.250-1.350) ng/mg creatinine, P = 0.124]. The uropathogenic Escherichia coli (UPEC) was the predominant isolate, n = 38 (43.7%). LL-37 levels between the E. coli isolates and the other isolated organisms. There was no significant correlation between plasma and urine LL-37 levels (r = 0.221), even when the data of the cases were analyzed separately. LL-37 is notably increased among patients with UTI compared with normal control subjects. Severity of UTI increases the levels of LL-37. The increased level was

  5. Assédio moral no trabalho: dilacerando oportunidades

    Directory of Open Access Journals (Sweden)

    Valdir Machado Valadão Júnior

    Full Text Available O assédio moral é um tema recorrente na literatura de negócios, com perspectivas, embora distintas, convergentes em um aspecto: essa prática deve ser banida das organizações, e, para isso, é necessário compreendê-la em maior profundidade. Nesse sentido, este estudo analisa processos de assédio moral com o objetivo de identificar as divergências e convergências entre as sentenças/processos procedentes verificados na Justiça do Trabalho, bem como analisa os discursos dos autos, das vítimas e dos gestores das organizações responsabilizadas, adotando como referência algumas das categorias de assédio moral. Diferentemente das pesquisas tradicionais, que consideram a perspectiva das vítimas, esta pesquisa vai além ao considerar, também, os gestores das organizações onde ocorreram os casos analisados. A estratégia de pesquisa utilizada é o estudo de caso, a partir da triangulação de dados obtidos com entrevistas com as vítimas e os gestores e análise de documentos. Com esse delineamento, o estudo foi dirigido em duas fases complementares: na primeira realizou-se o mapeamento das ocorrências de assédio moral na Justiça do Trabalho e na segunda analisaram-se dez casos de assédio moral contra mulheres que trabalharam em empresas privadas de grande porte. Os resultados mostram divergências expressivas nas categorias entre a ótica das vítimas e dos gestores Além disso, eles revelam, não apenas nos discursos dos entrevistados, uma miopia em relação às múltiplas causas de assédio moral no mundo do trabalho, mas, também, nos elementos dos processos jurídicos. Com ênfase nos gestores, as contradições e equívocos sobre o tema preocupam, e os álibis naturalizados, em suas expressões e falas, tentam levar a problemática para a margem, utilizando o tom de "brincadeira" e eufemismos.

  6. Effect of lectin (ScLL on fibroblasts stimulated with LPS - an in vitro study

    Directory of Open Access Journals (Sweden)

    Manuella Verdinelli de Paula REIS

    Full Text Available Abstract: The lectin (ScLL extracted from the Synadenium carinatum plant has been evaluated as an immunomodulator in diseases such as asthma, neosporosis and leishmaniasis. However, it has not yet been evaluated in the oral cavity. This study evaluated the effect of ScLL on viability, proliferation and release of IL-10 in human gingival fibroblasts (HGF stimulated with lipopolysaccharide (LPS. HGF were stimulated with LPS 1 µg/ml and treated with ScLL in concentrations of 10, 5 and 2 µg/ml for 1 and 5 h, and evaluated by flow cytometry for viability, apoptosis (initial/advanced and necrosis. The supernatant was collected to detect release of IL-10 by ELISA. The proliferation was assessed with the BrdU assay. Positive control consisted of cells maintained in Dulbecco's Modified Eagles Medium (DMEM, and the negative control, of those kept in tap water. Data were analyzed by ANOVA and Dunnett's test (α = 0.05. No significant difference was found for ScLL concentrations regarding viability or initial and advanced apoptosis (p=0.455. All the groups, including the positive control, had a significantly lower necrosis parameter than negative control at 5 h (p < 0.001. No difference was found for proliferation among the experimental groups (p = 0.832. ScLL at 5 and 2 µg/ml resulted in a lower release of IL-10 than positive and negative controls at 5 h (p = 0.047. The results indicated that ScLL concentrations tested were not cytotoxic, and had no effect on proliferation and release of IL-10 parameters. A thorough understanding of ScLL, regarding its immunomodulatory potential, may open the door to new perspectives for dentistry.

  7. Juventude, projetos de vida e ensino médio

    Directory of Open Access Journals (Sweden)

    Geraldo Leão

    2011-12-01

    Full Text Available O artigo apresenta parte dos resultados de pesquisa desenvolvida com jovens estudantes do ensino médio do estado do Pará. Por meio da metodologia de Grupos de Discussão, a pesquisa abordou a realidade do ensino médio na ótica dos jovens, analisando a relação que eles estabeleciam entre os seus projetos de vida e as contribuições da escola para a sua realização. A investigação revelou grande diversidade de projetos juvenis, evidenciando estratégias elaboradas a partir do contexto social, das idades da vida e de uma determinada postura diante do futuro, expressão de um cenário sociocultural marcado pelas incertezas. Os jovens revelaram que a escola é alvo de muitas expectativas, mas apontaram os seus limites em corresponder às suas demandas.

  8. Radiation accident Hospital San Juan de Dios August - September 1996

    International Nuclear Information System (INIS)

    Chin Cheng, R.

    2000-01-01

    In Costa Rica, a radiation accident occurred in 1996. It took place at the Radiotherapy Service of the San Juan de Dios Hospital, which affected 115 patients. The Unit of Radiotherapy made a mistake in the calibration of the new bundle because of the change of external faeces of cobalt 60 (Alycon II). The work is a retrospective study that describes what happened in this accident, and the medical consequences that derived from it [es

  9. Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats.

    Science.gov (United States)

    Begg, Denovan P; Mul, Joram D; Liu, Min; Reedy, Brianne M; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C

    2013-03-01

    Diet-induced obesity (DIO) reduces the ability of centrally administered insulin to reduce feeding behavior and also reduces the transport of insulin from the periphery to the central nervous system (CNS). The current study was designed to determine whether reversal of high-fat DIO restores the anorexic efficacy of central insulin and whether this is accompanied by restoration of the compromised insulin transport. Adult male Long-Evans rats were initially maintained on either a low-fat chow diet (LFD) or a high-fat diet (HFD). After 22 weeks, half of the animals on the HFD were changed to the LFD, whereas the other half continued on the HFD for an additional 8 weeks, such that there were 3 groups: 1) a LFD control group (Con; n = 18), 2) a HFD-fed, DIO group (n = 17), and 3) a HFD to LFD, DIO-reversal group (DIO-rev; n = 18). The DIO reversal resulted in a significant reduction of body weight and epididymal fat weight relative to the DIO group. Acute central insulin administration (8 mU) reduced food intake and caused weight loss in Con and DIO-rev but not DIO rats. Fasting cerebrospinal fluid insulin was higher in DIO than Con animals. However, after a peripheral bolus injection of insulin, cerebrospinal fluid insulin increased in Con and DIO-rev rats but not in the DIO group. These data provide support for previous reports that DIO inhibits both the central effects of insulin and insulin's transport to the CNS. Importantly, DIO-rev restored sensitivity to the effects of central insulin on food intake and insulin transport into the CNS.

  10. Long-term characterization of the diet-induced obese and diet-resistant rat model

    DEFF Research Database (Denmark)

    Madsen, Andreas Nygaard; Hansen, Gitte; Paulsen, Sarah Juel

    2010-01-01

    , namely the selectively bred diet-induced obese (DIO) and diet-resistant (DR) rat strains. We show that they constitute useful models of the human obesity syndrome. DIO and DR rats were fed either a high-energy (HE) or a standard chow (Chow) diet from weaning to 9 months of age. Metabolic characterization......, the results underscore the effectiveness of GLP-1 mimetics both as anti-diabetes and anti-obesity agents....

  11. Suicídio no Brasil, de 2000 a 2012

    Directory of Open Access Journals (Sweden)

    Daiane Borges Machado

    2015-03-01

    Full Text Available Objetivos Identificar as causas e o perfil das vítimas, analisar a mortalidade nos últimos 13 anos e mapear mudanças assistenciais e socioeconômicas. Métodos Utilizaram-se dados do SIM e Datasus. Calcularam-se as proporções das causas de suicídio segundo as categorias do CID10, X60-X84, estratificando-se por lesões (X70-X84 e autointoxicações (X60-X69. Analisaram-se as incidências por raça/cor, escolaridade e faixa etária, de 2000 a 2012. Compararam-se variações na mortalidade por suicídio com mudanças regionais nos indicadores de cobertura, características socioeconômicas e demográficas. Resultados As maiores causas de suicídio foram enforcamento, lesão por armas de fogo e autointoxicação por pesticidas. Os mais acometidos foram os menos escolarizados, indígenas (132% superior à população geral ou maiores de 59 anos (29% superior. As taxas entre homens são três vezes maiores em todas as regiões, embora tenha maior crescimento entre as mulheres (35%. A mortalidade mais elevada se encontra na região Sul (9,8/100.000 e o maior crescimento percentual, no Nordeste (72,4%. Conclusão A mortalidade por suicídio continua a crescer no país, com importantes variações regionais. A assistência à saúde também apresenta inequidades regionais, com importantes lacunas nos serviços de saúde. O Brasil ainda carece de programas governamentais que trabalhem efetivamente na prevenção do suicídio. Considera-se necessário estabelecer uma estratégia nacional de prevenção focalizando as populações de maior risco identificadas: índios, pessoas com menor escolaridade, homens e maiores de 60 anos, além da necessidade de ampliar a vigilância na comercialização ilegal de pesticidas.

  12. Impacto da redução do teor de sódio em alimentos processados no consumo de sódio no Brasil

    Directory of Open Access Journals (Sweden)

    Amanda de Moura Souza

    2016-01-01

    Full Text Available Resumo O objetivo do presente estudo foi avaliar o potencial impacto da redução do teor de sódio em alimentos processados no consumo médio de sódio na população brasileira. Um total de 32.900 participantes do primeiro Inquérito Nacional de Alimentação (2008-2009, com 10 anos e mais de idade, que forneceram dados de dois dias de consumo foram avaliados. As metas de redução de sódio pactuadas pelo Ministério da Saúde em 2010 e 2013 foram utilizadas como referência para determinar o teor máximo de sódio em 21 grupos de alimentos processados. Os resultados indicam que as metas de redução de sódio em alimentos processados têm pequeno impacto no consumo médio de sódio na população brasileira. Em 2017, a redução média esperada é de 1,5%, ficando os valores de consumo médio de sódio ainda acima do limite máximo recomendado de 2.000mg/dia. Portanto, dificilmente será possível alcançar a redução necessária no consumo de sódio no Brasil a partir de acordos voluntários nos moldes dos que aconteceram até o momento.

  13. The Glanerbrug Breccia: Evidence for a Separate L/LL-Chondritic Parent Body?

    Science.gov (United States)

    Welten, K. C.; Lindner, L.; Poorter, R. P. E.; Kallemeyn, G. W.; Rubin, A. E.; Wasson, J. T.

    1992-07-01

    INTRODUCTION. On April 7, 1990, a brecciated ordinary chondrite fell through the roof of a house near Glanerbrug in the Netherlands and was shattered to pieces. The total weight of the recovered fragments was about 800 g, the largest piece weighing 135 g. This main fragment clearly shows the inhomogeneous structure of the Glanerbrug: a dark-grey breccia occasionally containing blackish inclusions, separated from a light-grey breccia by a sharp boundary. Chondrules seem to be more common in the light grey parts. On the basis of earlier electron microprobe analyses of olivines and pyroxenes the light-grey portion was classified at the high Fa-Fs end of the L-field and the dark-grey part at the high Fa-Fs end of the LL-field [1]. Since it is not likely that the L and LL chondritic fragments originated on a single parent body, two alternative explanations were suggested: (i) The light-dark structure of the Glanerbrug is a characteristic feature of regolithic breccias, which once resided on or close to the surface of its parent body [2]. This lends some support to the idea that the light portion is an exotic clast in a dark host rock or vice versa; (ii) the two lithologies represent materials of a body having compositions between L and LL tentatively designated as L/LL [3,4]. Therefore additional electron microprobe analyses (EPMA) of silicates and kamacites in combination with neutron-activation analyses (INAA) of a light and a dark fragment and a noble gas analysis of a mixed light-dark fragment were undertaken. RESULTS and DISCUSSION. The light lithology in two thin sections shows olivine compositions in the L range (24.5+-0.3% Fa) and kamacite compositions (13.0+-1.3 mg/g Co) close to the LL range, plotting in the L/LL rather than in the L field on a kamacite-Co vs. olivine-Fa diagram [3,4]. Whereas only one aberrant olivine grain (out of 50) was found in the light portion, the dark portion is less homogeneous: one thin section shows olivine and kamacite

  14. The Beer/Bethe/Uexküll paper (1899) and misinterpretations surrounding 'vitalistic behaviorism'.

    Science.gov (United States)

    Mildenberger, Florian

    2006-01-01

    In the history of behaviorism the paper of the three physiologists Theodor Beer, Albrecht Bethe and Jakob von Uexküll from 1899 plays an important role. Many researchers were influenced by this paper and identified it as fundamental for objective psychological research. But during the period of its adoption (1900-1925) psychologists did not notice that Beer, Bethe and Uexküll had distanced themselves from their own paper, because it had been ignored in physiological and biological discussions. Moreover, one of the three (Beer) had to resign from the scientific community because of private scandal and another one (Uexküll) changed all of his views and left the base of objective science for subjective vitalism. However, this did not change his adoption of behaviorism.

  15. Rb-Sr Isotopic Systematics of Alkali-Rich Fragments in the Yamato-74442 LL-Chondritic Breccia

    Science.gov (United States)

    Yokoyama, T.; Misawa, K.; Okano, O.; Shih, C.-Y.; Nyquist, L. E.; Simo, J. I.; Tappa, M. J.; Yoneda, S.

    2012-01-01

    Alkali-rich igneous fragments were identified in the brecciated LL-chondrites, Kr henberg (LL5)], Bhola (LL3-6) and Yamato (Y)-74442 (LL4), and show characteristic fractionation patterns of alkaline elements. The K-Rb-Cs-rich fragments in Kr henberg, Bhola, and Y-74442 are very similar in mineralogy and petrography (olivine + pyroxene + glass), suggesting that they could have come from related precursor materials. We have undertaken Rb-Sr isotopic studies on alkali-rich fragments in Y-74442 to precisely determine their crystallization ages and the isotopic signatures of their precursor material(s).

  16. Homicídio seguido de suicídio: relato de caso Homicide followed by suicide: case report

    Directory of Open Access Journals (Sweden)

    Helena Dias de Castro Bins

    2009-01-01

    Full Text Available OBJETIVO: Examinar o fenômeno clínico de homicídio seguido de suicídio (HS a partir de um caso no qual o desfecho de suicídio não ocorreu por motivos alheios à vontade e às ações do sujeito. DESCRIÇÃO DO CASO: Trata-se do caso de um homem que matou sua namorada por ciúmes, por ocasião do término do relacionamento entre ambos, tentando, a seguir, o suicídio. No presente artigo, é dada especial ênfase aos aspectos forenses do caso, avaliado para fins de determinação de responsabilidade penal e acompanhado no Instituto Psiquiátrico Forense Dr. Maurício Cardoso, Porto Alegre (RS. COMENTÁRIOS: Ressalta-se que, ao se modificar o desfecho de um caso típico de HS, por não ter se consumado o suicídio do homicida, dois aspectos assumem relevância: as consequências legais a serem enfrentadas pelo sujeito e o manejo do impacto psíquico no sobrevivente. Do ponto de vista da prevenção, o conhecimento do fenômeno HS e dos fatores descritos como associados a ele justificaria uma constante atenção ao tema por parte dos profissionais de saúde mental. O presente relato foi autorizado pelo paciente através de termo de consentimento livre e esclarecido.OBJECTIVE: The clinical phenomenon of homicide followed by suicide (HS is examined through a case in which suicide was avoided despite the individual's will and actions. CASE DESCRIPTION: A man killed his girlfriend at the end of the relationship because of jealousy. After that, he attempted suicide. Special emphasis is given to the forensic aspects of the case, which has been assessed to determinate the individual's criminal responsibility and has been followed up at the Forensic Psychiatric Institute Dr. Maurício Cardoso, in Porto Alegre, state of Rio Grande do Sul, Brazil. COMMENTS: When the outcome of a typical case of HS is modified and the suicide of the murderer is not accomplished, two aspects become important: the legal consequences to be faced by the murderer and the

  17. Sisällönanalyysi Journal of Aesthetic Nursing -julkaisusta

    OpenAIRE

    Pajunen, Eveliina

    2016-01-01

    Esteettisellä hoitotyöllä tarkoitetaan sellaisia elektiivisiä ja minimaalisen invasiivisia toimenpiteitä, joiden tarkoituksena on parantaa potilaan tyytyväisyyttä hänen fyysiseen olemukseensa. Tässä opinnäytetyössä käsitellään sairaanhoitajien tekemiä non-operatiivisia esteettisiä hoitotoimenpiteitä. Opinnäytetyön tarkoituksena oli tehdä sisällönanalyysi Journal of Aesthetic Nursing -julkaisusta, joka on ainut esteettisille sairaanhoitajille kohdennettu vertaisarvioitu julkaisu. Julkaisu ...

  18. M4FT-15LL0806062-LLNL Thermodynamic and Sorption Data FY15 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wolery, T. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-31

    This progress report (Milestone Number M4FT-15LL0806062) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within Work Package Number FT-15LL080606. The focus of this research is the thermodynamic modeling of Engineered Barrier System (EBS) materials and properties and development of thermodynamic databases and models to evaluate the stability of EBS materials and their interactions with fluids at various physicochemical conditions relevant to subsurface repository environments. The development and implementation of equilibrium thermodynamic models are intended to describe chemical and physical processes such as solubility, sorption, and diffusion.

  19. M4FT-16LL080302052-Update to Thermodynamic Database Development and Sorption Database Integration

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Inst.. Physical and Life Sciences; Wolery, T. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Akima Infrastructure Services, LLC; Atkins-Duffin, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Global Security

    2016-08-16

    This progress report (Level 4 Milestone Number M4FT-16LL080302052) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Argillite Disposal R&D Work Package Number FT-16LL08030205. The focus of this research is the thermodynamic modeling of Engineered Barrier System (EBS) materials and properties and development of thermodynamic databases and models to evaluate the stability of EBS materials and their interactions with fluids at various physico-chemical conditions relevant to subsurface repository environments. The development and implementation of equilibrium thermodynamic models are intended to describe chemical and physical processes such as solubility, sorption, and diffusion.

  20. On radiogenic nature of xenon-X in carbonaceous and LL chondrites

    International Nuclear Information System (INIS)

    Gerling, Eh.K.

    1982-01-01

    The nature of Xe-X from the mineral fraction produced during the differential dissolution of carbonaceous and LL chondrites was investigated using literature data on the age of some meteorites and their fractions and quantities of fission 136 Xe contained in them. A graph of lg fission 136 Xe against the age of meteorites was plotted; the decay constant of a hypothetical superheavy nucleus was calculated using the graph and equaled 1x10 - 7 year - 1 . The calculations served as a forcible argument for the radiogenic nature of xenon with 136 and 134 mass in carbonaceous and LL chondrites

  1. Does smoking affect gingival crevicular fluid LL-37 levels following non-surgical periodontal treatment in chronic periodontitis?

    Science.gov (United States)

    Türkoğlu, Oya; Eren, Gülnihal; Emingil, Gülnur; Azarsız, Elif; Kutukculer, Necil; Atilla, Gül

    2016-01-01

    LL-37 contributes to maintaining the balance between health and disease. Smoking is a risk factor for periodontitis that impairs neutrophil functions. The aim of the present study was to comparatively evaluate gingival crevicular fluid (GCF) LL-37 levels in smoker and non-smoker chronic periodontitis (CP) patients and controls, as well as the effect of non-surgical periodontal treatment on GCF LL-37 levels. Thirty-one CP patients (16 smokers, 15 non-smokers) and thirty-one controls (16 smokers, 15 non-smokers) were included in the study. CP patients received non-surgical treatment. GCF LL-37 levels and periodontal parameters were assessed at baseline, 1 and 3 months after completion of non-surgical periodontal treatment. GCF LL-37 levels were analyzed by ELISA. No significant difference was observed in GCF LL-37 levels between smoker and non-smoker controls (p>0.05). Smoker CP group had significantly lower GCF LL-37 level than non-smoker CP group at baseline (pnon-smoker CP group at first week, 1 and 3 months after completion of non-surgical periodontal treatment (psmoker CP group (p>0.05). Periodontal parameters were correlated with GCF LL-37 levels in non-smoker CP group (psmoker CP group (p>0.05). GCF LL-37 levels do not seem to be affected from smoking in periodontal health. However, smoking might have a suppressive effect on GCF LL-37 levels in CP. Non-surgical treatment is effective in decreasing GCF LL-37 levels in non-smoker CP patients but not in smokers with CP. Copyright © 2015. Published by Elsevier Ltd.

  2. L-L multilevel boost converter topology for renewable energy applications

    DEFF Research Database (Denmark)

    Bhaskar, Mahajan Sagar; Padmanaban, Sanjeevikumar; Fedák, Viliam

    2017-01-01

    ; such as a photovoltaic (PV) system with a Multilevel Inverter (MLI), electrical drives, automotive, hybrid electric cars etc. The proposed topology is derived by attaching the Cockcroft Walton (CW) multiplier to an upper L-converter of the LL topology of XY family. The mode of operation of L-LMBC with mathematical...

  3. Physical properties, structure and fracturing of the Chelyabinsk LL5 meteorite body

    Czech Academy of Sciences Publication Activity Database

    Grokhovsky, V. I.; Kohout, Tomáš; Gritsevich, M.; Koneva, E. V.

    2014-01-01

    Roč. 49, Special issue 1 (2014), pdf 5364-pdf 5364 ISSN 1086-9379. [Annual Meeting of the Meteoritical Society /77./. 08.09.2014-13.09.2014, Casablanca] Institutional support: RVO:67985831 Keywords : Chelyabinsk * LL chondrite * physical properties * structure * mechanical properties * stress Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics http://www.hou.usra.edu/meetings/metsoc2014/pdf/5364.pdf

  4. The School Business Official: Ten Habits You'll Need To Succeed.

    Science.gov (United States)

    Giambrone, William, Jr.

    2001-01-01

    Describes 10 habits school business officials need to succeed: organization, time management, delegation, planning, collaboration, personal development, creativity, empathy, ethos, and leadership. Based on book "The School Business Official: Ten Habits You'll Need To Succeed," published by the Pennsylvania Association of School Business…

  5. Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging

    NARCIS (Netherlands)

    Ordonez Alvarez, Soledad; Amarullah, Ilham H; Wubbolts, Richard W; Veldhuizen, Edwin J A; Haagsman, Henk P

    2014-01-01

    Antifungal mechanisms of action of two cathelicidins, chicken CATH-2 and human LL-37, were studied and compared with the mode of action of the salivary peptide histatin 5 (Hst5). Candida albicans was used as a model organism for fungal pathogens. Analysis by live-cell imaging showed that the

  6. Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells

    Directory of Open Access Journals (Sweden)

    Justyna Agier

    2018-01-01

    Full Text Available Undoubtedly, mast cells take part in host defense against microorganisms as they are numerous at the portal of infection, they release many proinflammatory and antimicrobial mediators, and they express pattern recognition receptors, such as TLRs. These receptors play a key role in recognition and binding molecules associated with microorganisms and molecules associated with damage. Cathelicidins exhibit direct antimicrobial activities against a broad spectrum of microbes by perturbing their cell membranes. Accumulating evidence suggests a role for these molecules in supporting cell activation. We examined the impact of human cathelicidin LL-37 on tissue mast cell TLR expression and distribution. Depending on context, we show that LL-37 stimulation resulted in minor to major effects on TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9 expression. Confocal microscopy analysis showed that, upon stimulation, TLRs may translocate from the cell interior to the surface and conversely. FPR2 and EGFR inhibitors reduced the increase in expression of selected receptors. We also established that LL-37 acts as a powerful inducer of CCL3 and ROS generation. These results showed that in response to LL-37, mast cells enhance the capability to detect invading pathogens by modulation of TLR expression in what may be involved FPR2 or EGFR molecules.

  7. Effektregnskab for projektet Digitales ll – Det svære valg

    DEFF Research Database (Denmark)

    Mark, Stine

    Effektregnskabet for projektet Digitales ll – Det svære valg er udarbejdet af forskningscenteret INCEVIDA, Aalborg Universitet 2012. Rapporten er gennemført i et samarbejde mellem INCEVIDA, KulturarvNord og Bangsbo Museum. Effektregnskabet tager udgangspunkt i en model for oplevelsesøkonomisk...

  8. checkCIF/PLATON report Datablock: ll5182-c2m

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: ll5182-c2m. Bond precision:.

  9. Episódios de cuidados: um conceito em saúde pública

    OpenAIRE

    Gentil,Lia; Vanasse,Alain; Xhignesse,Marianne

    2013-01-01

    INTRODUÇÃO: Esse artigo apresenta uma revisão da literatura sobre a definição de episódio de cuidados. O conceito de episódio de cuidados na pesquisa em serviços de saúde emergiu nos anos 60. Os episódios têm sido descritos em três perspectivas diferentes: a do paciente (episódio de mal estar), a do prestador do serviço (episódio de doença) e do seu financiador (episódio de cuidados). OBJETIVO: O principal objetivo desse estudo é apresentar uma revisão da literatura da definição operacional d...

  10. Elevated mercury concentrations in humans of Madre de Dios, Peru.

    Directory of Open Access Journals (Sweden)

    Katy Ashe

    Full Text Available The enormous increase in practically unregulated mining in Madre de Dios Peru is leading to massive release of liquid elemental mercury to the environment. Rapidly increasing global prices for gold are causing a massive upsurge in artisanal mining in the Peruvian Amazon, considered to be one of the most biodiverse places on the planet. This study identifies the current levels of mercury in the human population, through identifying levels of total mercury in human hair in mining zones of Madre de Dios Department and in the nearby city of Puerto Maldonado. A regression analysis reveals that fish consumption, gender, and location of residence were significant indicators of mercury levels; while duration of residence and age had no significant relationship to mercury levels. Increased fish consumption levels were the strongest indicators of increased total mercury levels across the entire population. The levels of total mercury in hair was significantly (α = 0.05 higher in mining zones, than Puerto Maldonado. In both areas men had significantly higher levels than women, likely due to a difference in metabolism or varying levels of direct involvement in gold mining- a male predominated industry. This is the first study to show the health threat that mercury poses to this region, however further research needs to be done to gain a more refined understanding of the predominant routes of exposure in this population.

  11. Elevated mercury concentrations in humans of Madre de Dios, Peru.

    Science.gov (United States)

    Ashe, Katy

    2012-01-01

    The enormous increase in practically unregulated mining in Madre de Dios Peru is leading to massive release of liquid elemental mercury to the environment. Rapidly increasing global prices for gold are causing a massive upsurge in artisanal mining in the Peruvian Amazon, considered to be one of the most biodiverse places on the planet. This study identifies the current levels of mercury in the human population, through identifying levels of total mercury in human hair in mining zones of Madre de Dios Department and in the nearby city of Puerto Maldonado. A regression analysis reveals that fish consumption, gender, and location of residence were significant indicators of mercury levels; while duration of residence and age had no significant relationship to mercury levels. Increased fish consumption levels were the strongest indicators of increased total mercury levels across the entire population. The levels of total mercury in hair was significantly (α = 0.05) higher in mining zones, than Puerto Maldonado. In both areas men had significantly higher levels than women, likely due to a difference in metabolism or varying levels of direct involvement in gold mining- a male predominated industry. This is the first study to show the health threat that mercury poses to this region, however further research needs to be done to gain a more refined understanding of the predominant routes of exposure in this population.

  12. Assédio moral nos ambientes corporativos

    Directory of Open Access Journals (Sweden)

    Yumara Lúcia Vasconcelos

    Full Text Available Resumo:Esse artigo teve como objetivo caracterizar o assédio moral nos ambientes corporativos à luz do paradigma conceitual do que se concebe como "dignidade humana" e violação do princípio jurídico da boa-fé. Especificamente, visou identificar padrões na argumentação jurídica e no enquadramento de práticas nocivas à saúde mental do trabalhador. O estudo, de natureza qualitativa, tomou por base o estudo de situações jurídicas, orientando-se pela demanda por definição e caracterização da prática assediadora no âmbito organizacional e dos limites do conceito da dignidade humana. Como principal resultado, o estudo colocou em contraste a necessidade de contextualização do fato propulsor da denúncia e caracterização do assédio, sem olvidar a relevância do significado ou sentido atribuído pelo indivíduo ao fenômeno analisado.

  13. Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats Óleo de linhaça, oliva e peixe influenciam os lipídios plasmáticos, migração de linfócitos e morfometria intestinal de ratos Wistar

    Directory of Open Access Journals (Sweden)

    Damiana Diniz Rosa

    2010-06-01

    Full Text Available PURPOSE: Evaluate the effect of flaxseed, olive and fish oil on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats. METHODS: Thirty Wistar male rats were divided into four groups, which received the AIN-93M diet, with changes only to their lipid source: flaxseed, olive, fish, and soy oil (control group. The serum was separated for the biochemical parameter analysis. A histological evaluation was performed in the ileal portion. RESULTS: The group which was fed fish oil presented lower values when compared to the other treatments for Total Cholesterol, High-density Lipoprotein Cholesterol and Triacylglycerol (pOBJETIVO: Avaliar o efeito dos óleos de linhaça, oliva e peixe no perfil lipídico, preservação das vilosidades e migração de linfócitos na mucosa intestinal de ratos Wistar. MÉTODOS: Trinta ratos Wistar foram divididos em quarto grupos e receberam dieta AIN-93M, modificando para cada grupo apenas a fonte lipídica: óleo de linhaça, oliva, peixe e soja ( grupo controle. O soro foi separado para análise dos parâmetros bioquímicos. A análise histológica foi realizada na porção ileal. RESULTADOS: O grupo que recebeu óleo de peixe apresentou menores valores de colesterol total, lipoproteína de alta densidade e triacilglicerol (p<0.05. Os animais tratados com óleo de peixe e oliva apresentaram melhor preservação das vilosidades intestinais. Menor deposição de linfócitos foi observado no grupo tratado com óleo de linhaça (p<0.001. CONCLUSÃO: Este estudo demonstrou que os óleos de linhaça, oliva e peixe apresentam diferentes respostas em relação ao óleo de soja na preservação da mucosa intestinal e proliferação de linfócitos em ratos Wistar.

  14. Teletandem e episódios relacionados a cultura

    Directory of Open Access Journals (Sweden)

    João Antonio TELLES

    2015-12-01

    Full Text Available Teletandem é um contexto telecolaborativo de aprendizagem que envolve dois falantes nativos (ou competentes de diferentes línguas. Utilizando o Skype, cada participante faz papel de aluno por meia hora, falando e praticando a língua do seu parceiro. Este artigo enfoca a interação em teletandem entre dois estudantes universitários - uma brasileira e um estadunidense. Na primeira parte, sustentamos nossa pressuposição de que os participantes do teletandem compartilham informações acerca das respectivas culturas. Na segunda, apresentamos cinco dimensões do conceito de cultura, definimos aprendizagem cultural e propomos uma unidade de análise para interpretação dos dados - o episódio relacionado a cultura. Por fim, sugerimos diretrizes para futuras pesquisas relacionadas à aprendizagem de línguas e culturas em contextos colaborativos on-line.

  15. Comentario al Libro Juan de Dios Carrasquilla, Hombre de Ciencia”

    Directory of Open Access Journals (Sweden)

    José Félix Patiño Restrepo

    2004-06-01

    Full Text Available

    La historia de la medicina es, en gran parte, la historia de la ciencia y la historia de la ciencia es la historia de la humanidad. A su vez, las biografías de los médicos conforman como lo dice Sherwin Nuland, la biografía de la medicina. Adolfo De Francisco Zea presenta la tercera biografía de médicos ilustres de Colombia. Primero en 1997 apareció su obra El Doctor José Félix Merizalde y la Medicina a comienzos del siglo XIX en Santa Fe de Bogotá. Luego, en 1999 como la anterior con el patrocinio de la Academia Colombiana de Historia, el estudio biográfico sobre Luis Zea Uribe. Su Vida y su Época, su eminente abuelo materno que tanta influencia tuvo en la escogencia de la medicina como vocación por Adolfo De Francisco.

    La presente obra Juan de Dios Carrasquilla, Hombre de Ciencia, es otra formidable biografía de un personaje que vivió a finales del siglo XIX, la gran revolución científica desatada con el descubrimiento del origen microbiano de las enfermedades, y como lo escribe el autor, “A Juan de Dios Carrasquilla le correspondió hacer el tránsito gradual que va desde las visiones clínicas de un pasado cercano, hasta las concepciones científicas de un presente más rico en soluciones para los problemas médicos, y más adecuado para el desarrollo de las investigaciones que habría de realizar en el difícil y poco explorado campo de la más temible de las enfermedades de todos los tiempos: la lepra”.

    Adolfo De Francisco presenta, en elegante prosa y con base en formidable documentación, la personalidad de Juan de Dios Carrasquilla, cuya vida fue fundamentalmente una continuada aventura intelectual. Como los médicos más destacados de su época, Carrasquilla viajó a Europa, motivado también por su interés en la mineralogía y la geología. En efecto, este médico, nieto de médico, desde temprana edad cultivó una afición especial por las ciencias naturales.

    Es así como De Francisco destaca

  16. Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells

    OpenAIRE

    Liu, Q.; Liu, J.; Roschmann, K.I.L.; Egmond, D. van; Golebski, K.; Fokkens, W.J.; Wang, D.; Drunen, C.M. van

    2013-01-01

    HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely unknown. Therefore, we investigated the effects of two non-selective HDACi, trichostatin A (TSA) and sodium butyrate (SB), on the expression of the cathelicidin LL-37 in human airway epithelial cells. LL3...

  17. K-Ca Dating of Alkali-Rich Fragments in the Y-74442 and Bhola LL-Chondritic Breccias

    Science.gov (United States)

    Yokoyama, T; Misawa, K.; Okano, O; Shih, C. -Y.; Nyquist, L. E.; Simon, J. I.; Tappa, M. J.; Yoneda, S.

    2013-01-01

    Alkali-rich igneous fragments in the brecciated LL-chondrites, Krahenberg (LL5) [1], Bhola (LL3-6) [2], Siena (LL5) [3] and Yamato (Y)-74442 (LL4) [4-6], show characteristic fractionation patterns of alkali and alkaline elements [7]. The alkali-rich fragments in Krahenberg, Bhola and Y-74442 are very similar in mineralogy and petrography, suggesting that they could have come from related precursor materials [6]. Recently we reported Rb-Sr isotopic systematics of alkali-rich igneous rock fragments in Y-74442: nine fragments from Y-74442 yield the Rb-Sr age of 4429 plus or minus 54 Ma (2 sigma) for lambda(Rb-87) = 0.01402 Ga(exp -1) [8] with the initial ratio of Sr-87/Sr-86 = 0.7144 plus or minus 0.0094 (2 sigma) [9]. The Rb-Sr age of the alkali-rich fragments of Y-74442 is younger than the primary Rb-Sr age of 4541 plus or minus 14 Ma for LL-chondrite whole-rock samples [10], implying that they formed after accumulation of LL-chondrite parental bodies, although enrichment may have happened earlier. Marshall and DePaolo [11,12] demonstrated that the K-40 - Ca-40 decay system could be an important chronometer as well as a useful radiogenic tracer for studies of terrestrial rocks. Shih et al. [13,14] and more recently Simon et al. [15] determined K-Ca ages of lunar granitic rocks, and showed the application of the K-Ca chronometer for K-rich planetary materials. Since alkali-rich fragments in the LL-chondritic breccias are highly enriched in K, we can expect enhancements of radiogenic Ca-40. Here, we report preliminary results of K-Ca isotopic systematics of alkali-rich fragments in the LL-chondritic breccias, Y-74442 and Bhola.

  18. Initiated into Subordination. On Joyce Carol Oates’s I’ll Take You There

    Directory of Open Access Journals (Sweden)

    Zawadzka Anna

    2016-12-01

    Full Text Available The article proposes a sociological reading of the novel I’ll Take You There by Joyce Carol Oates. Though the book can be classified as an initiation novel, it also constitutes an accusation of the very procedure of initiation as forcing individuals to agree and adapt to unfair social mechanisms. The context of the protagonist’s struggles is provided by the social structure of the early-1960s United States, with its inherent misogyny, anti-Semitism, racism and classism. All these factors shape her destiny in accordance with the logic of social reproduction. A destiny of overwhelming power of allocation, which the heroine is trying to resist. As an academic novel, I’ll Take You There is also an insightful deconstruction of the universalism preached within the Western academic world, and especially philosophy.

  19. Rare top decay t{yields}c anti ll as a probe of new physics

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Cruz, J.L.; Diaz-Furlong, A. [BUAP, Cuerpo Academico de Particulas, Campos y Relatividad Facultad de Ciencias Fisico-Matematicas, Apdo. Postal 1364, Puebla, Pue. (Mexico); Gaitan-Lozano, R.; Montes de Oca Y, J.H. [UNAM, Departamento de Fisica, FES-Cuautitlan, Estado de Mexico (Mexico)

    2012-08-15

    The rare top decay t{yields}c anti ll, which involves flavor violation, is studied as a possible probe of new physics. This decay is analyzed with one of the simplest Standard Model extensions with additional gauge symmetry formalism. The considered extension is the Left-Right Symmetric Model, including a new neutral gauge boson Z' that allows one to obtain the decay at tree level through Flavor-Changing Neutral Currents (FCNC) couplings. The neutral gauge boson couplings are considered diagonal but family non-universal in order to induce these FCNC. We find BR(t{yields}c anti ll){proportional_to}10{sup -13} for the range 1 TeV{<=}M{sub Z'}{<=}3 TeV. (orig.)

  20. Purification and partial characterization of bacteriocin produced by Lactococcus lactis ssp. lactis LL171.

    Science.gov (United States)

    Kumari, Archana; Akkoç, Nefise; Akçelik, Mustafa

    2012-04-01

    Lactic acid bacteria (LAB) are possessing ability to synthesize antimicrobial compounds (like bacteriocin) during their growth. In this regard, novel bacteriocin compound secreting capability of LAB isolated from Tulum Cheese in Turkey was demonstrated. The synthesized bacteriocin was purified by ammonium sulphate precipitation, dialysis and gel filtration. The molecular weight (≈3.4 kDa) of obtained bacteriocin was confirmed by SDS-PAGE, which revealed single peptide band. Molecular identification of LAB strain isolated from Tulum Cheese was conducted using 16S rDNA gene sequencing as Lactococcus lactis ssp. lactis LL171. The amino acid sequences (KKIDTRTGKTMEKTEKKIELSLKNMKTAT) of the bacteriocin from Lactococcus lactis ssp. lactis LL171 was found unique and novel than reported bacteriocins. Further, the bacteriocin was possessed the thermostable property and active at wide range of pH values from 1 to 11. Thus, bacteriocin reported in this study has the potential applications property as food preservative agent.

  1. Composite-model view of the ll-barγγ events at LEP

    International Nuclear Information System (INIS)

    Akama, Keiichi; Terazawa, Hidezumi.

    1993-09-01

    We examine phenomenological consistency of composite-model pictures for the ll-barγγ events at LEP: the picture with an extra boson and that with an excited lepton. It turns out that the former is inconsistent with the Bhabha scattering data while the latter is consistent with the existing experimental data as far as the excited lepton is lighter than 200 GeV. (author)

  2. Bitumen and cement solidifications of LL and ML liquid radwaste. The SGN experience

    International Nuclear Information System (INIS)

    Tchemitcheff, E.; Roux, P.

    1993-01-01

    The presentation is focused on the thin-film evaporator technology and the experience gained in the field of the NPPs and research centers on radwaste conditioning. As early as 1970, SGN was licensed by the CEA for the bituminization of LL and ML radwaste. With the support of EDF and COGEMA, SGN has been performing in depth research on cement solidification of borated concentrates and ion exchange resins generated by reactors or reprocessing plant since 1983

  3. Lymphoma imaging with a new technetium-99m labelled antibody, LL2

    International Nuclear Information System (INIS)

    Murthy, S.; Sharkey, R.M.; Goldenberg, D.M.; Lee, R.E.; Pinsky, C.M.; Hansen, H.J.; Burger, K.; Swayne, L.C.

    1992-01-01

    The lesion detection capability of a new technetium-99m labelled B-cell lymphoma monoclonal antibody (MoAb) imaging agent, LL2, was evaluated in 8 patients with non-Hodgkin's lymphoma and 1 patient with chronic lymphocytic leukaemia. The MoAb kit consists of a 1-vial, 1-mg Fab' form of LL2 ready for instant labelling with technetium. The patients were injected with ∝925 MBq (25 mCi) of 99m Tc-LL2 Fab' (1 mg), and planar and single photon emission tomography (SPET) studies were performed at 3-4 h post injection and at 24 h. There was no evidence of thyroid or stomach activity up to 24 h. Uniform splenic uptake was seen in all patients. Two non-lymphoma patients were also administered with the same agent and demonstrated a similar splenic distribution; therefore, splenic targeting was not scored as tumour-specific. A total of 29 from 48 tumour sites were detected by scintigraphy, including tumours of various grades and histological types. Excluding 1 patient who had a large tumour burden of over 500 g, 29 of 33 lesions were detected. One patient was free of disease at the time of the study and had a negative scan. Another patient showed excellent targeting of gallium-negative sites in the liver and bone. The bone involvement was not known prior to the antibody study and was subsequently confirmed by a bone scan. Additional sites of MoAb localization could not be followed in this group, since most patients went on to radioimmunotherapy immediately following the 99m Tc-LL2 study. However, these initial results suggest that this new 99m Tc-labelled antibody imaging kit should be further investigated for its potential role in the staging and follow-up of lymphoma patients. (orig.)

  4. The taxonomic status of Bryum arachnoideum C. Müll. and B. lanatum (P. Beauv.) Brid.

    OpenAIRE

    Frahm, Jan-Peter

    2002-01-01

    A study of an isotype of Bryum arachnoideum C. Müll., a poorly understood species described from tropical Africa, revealed that this species is distinct from B. argenteum Hedw. var. lanatum (P. Beauv.) Hampe. The differences between both species are listed. All specimens from tropical Africa named as B. arachnoideum by the author must be attributed to B. argenteum var. lanatum. The differences between B. argenteum var. argenteum and var. lanatum, both morphologically and ecologically, are so ...

  5. An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.

    Science.gov (United States)

    Hudson, André O; Singh, Bijay K; Leustek, Thomas; Gilvarg, Charles

    2006-01-01

    Although lysine (Lys) biosynthesis in plants is known to occur by way of a pathway that utilizes diaminopimelic acid (DAP) as a central intermediate, the available evidence suggests that none of the known DAP-pathway variants found in nature occur in plants. A new Lys biosynthesis pathway has been identified in Arabidopsis (Arabidopsis thaliana) that utilizes a novel transaminase that specifically catalyzes the interconversion of tetrahydrodipicolinate and LL-diaminopimelate, a reaction requiring three enzymes in the DAP-pathway variant found in Escherichia coli. The LL-DAP aminotransferase encoded by locus At4g33680 was able to complement the dapD and dapE mutants of E. coli. This result, in conjunction with the kinetic properties and substrate specificity of the enzyme, indicated that LL-DAP aminotransferase functions in the Lys biosynthetic direction under in vivo conditions. Orthologs of At4g33680 were identified in all the cyanobacterial species whose genomes have been sequenced. The Synechocystis sp. ortholog encoded by locus sll0480 showed the same functional properties as At4g33680. These results demonstrate that the Lys biosynthesis pathway in plants and cyanobacteria is distinct from the pathways that have so far been defined in microorganisms.

  6. Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37.

    Science.gov (United States)

    Schögler, Aline; Muster, Ricardo J; Kieninger, Elisabeth; Casaulta, Carmen; Tapparel, Caroline; Jung, Andreas; Moeller, Alexander; Geiser, Thomas; Regamey, Nicolas; Alves, Marco P

    2016-02-01

    Vitamin D has immunomodulatory properties in the defence against pathogens. Its insufficiency is a widespread feature of cystic fibrosis (CF) patients, which are repeatedly suffering from rhinovirus (RV)-induced pulmonary exacerbations.To investigate whether vitamin D has antiviral activity, primary bronchial epithelial cells from CF children were pre-treated with vitamin D and infected with RV16. Antiviral and anti-inflammatory activity of vitamin D was assessed. RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10(-7 )M, pvitamin D in CF cells. Vitamin D did not exert anti-inflammatory properties in RV-infected CF cells. Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (pvitamin D through the induction of LL-37. Clinical studies are needed to determine the importance of an adequate control of vitamin D for prevention of virus-induced pulmonary CF exacerbations. Copyright ©ERS 2016.

  7. O sentido social do suicídio no trabalho

    Directory of Open Access Journals (Sweden)

    Selma Venco

    2010-05-01

    Full Text Available

    Este artigo objetiva debater a ocorrência, na sociedade, de suicídios com vínculo explícito ou suposto com o trabalho. Se, ao longo da história, tais fatos eram registrados entre ocupações que lidavam cotidianamente com situações difíceis como bombeiros, policiais, carcereiros e enfermeiros, mais recentemente estes têm sido observados em ocupações diferenciadas, quais sejam: as expostas a lógicas de gestão pautadas pela individualização na avaliação, pela organização do trabalho, regulada crescentemente pela máxima qualidade da produção e pelo intenso processo de terceirização. Tais fenômenos têm evidenciado precarização e degradação das condições de trabalho como causa do surgimento de novas patologias e, entre elas, o suicídio, no trabalho

    Abstract

    This article aims to discuss the occurrence of suicides link to work. If, through history, such events were recorded between occupations dealing with difficult situations such as firefighters, policemen, prison guards and nurses, more recently they have been observed in different occupations exposed to the logics of individualization management guided by evaluation, work organization, governed increasingly by the highest production quality and intense process of outsourcing. Such processes have shown instability and deterioration of working conditions as the cause of the emergence of new diseases and suicide in the workplace.

     

  8. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Shu Meguro

    2014-01-01

    Full Text Available Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%. Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=−0.450, P<0.01, triglyceride (r=0.445, P<0.01, and high sensitive C-reactive protein (r=0.316, P<0.01 but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=−0.411, P<0.01 and high sensitive C-reactive protein (β=0.193, P<0.05. Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

  9. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol

    KAUST Repository

    Liu, Xiang

    2013-03-01

    We have determined the X-ray crystal structures of the NADH-dependent alcohol dehydrogenase LlAdhA from Lactococcus lactis and its laboratory-evolved variant LlAdhA(RE1) at 1.9Å and 2.5Å resolution, respectively. LlAdhA(RE1), which contains three amino acid mutations (Y50F, I212T, and L264V), was engineered to increase the microbial production of isobutanol (2-methylpropan-1-ol) from isobutyraldehyde (2-methylpropanal). Structural comparison of LlAdhA and LlAdhA(RE1) indicates that the enhanced activity on isobutyraldehyde stems from increases in the protein\\'s active site size, hydrophobicity, and substrate access. Further structure-guided mutagenesis generated a quadruple mutant (Y50F/N110S/I212T/L264V), whose KM for isobutyraldehyde is ∼17-fold lower and catalytic efficiency (kcat/KM) is ∼160-fold higher than wild-type LlAdhA. Combining detailed structural information and directed evolution, we have achieved significant improvements in non-native alcohol dehydrogenase activity that will facilitate the production of next-generation fuels such as isobutanol from renewable resources.

  10. Paralogs hnRNP L and hnRNP LL exhibit overlapping but distinct RNA binding constraints.

    Directory of Open Access Journals (Sweden)

    Sarah A Smith

    Full Text Available HnRNP (heterogeneous nuclear ribonucleoprotein proteins are a large family of RNA-binding proteins that regulate numerous aspects of RNA processing. Interestingly, several paralogous pairs of hnRNPs exist that exhibit similar RNA-binding specificity to one another, yet have non-redundant functional targets in vivo. In this study we systematically investigate the possibility that the paralogs hnRNP L and hnRNP LL have distinct RNA binding determinants that may underlie their lack of functional redundancy. Using a combination of RNAcompete and native gel analysis we find that while both hnRNP L and hnRNP LL preferentially bind sequences that contain repeated CA dinucleotides, these proteins differ in their requirement for the spacing of the CAs. Specifically, hnRNP LL has a more stringent requirement for a two nucleotide space between CA repeats than does hnRNP L, resulting in hnRNP L binding more promiscuously than does hnRNP LL. Importantly, this differential requirement for the spacing of CA dinucleotides explains the previously observed differences in the sensitivity of hnRNP L and LL to mutations within the CD45 gene. We suggest that overlapping but divergent RNA-binding preferences, as we show here for hnRNP L and hnRNP LL, may be commonplace among other hnRNP paralogs.

  11. La Iglesia Universal del Reino de Dios en Europa

    Directory of Open Access Journals (Sweden)

    Nilton Cezar Pereira Pinto

    2009-03-01

    Full Text Available El proceso por el cual la Iglesia Universal del Reino de Dios (IURD se ha expandido por decenas de países, incluso Portugal e Inglaterra, es un capítulo importante de una de las principales transformaciones religiosas de finales del siglo XX: la transformación del petencostalismo en religión global y el cambio del centro, no sólo numérico, sino también del impulso expansionista internacional, para regiones distantes de los centros históricos del protestantismo._____________ABSTRACT:The process by which the Universal Church of the Kingdom of God (IURD has spreaded in dozens of countries, including Portugal and England, is an important part of a major religious transformation of the late twentieth century: the transformation of petencostalism in Global religion and the creation of more centres. It is also analized the international expansionist impulse toward regions far away from the historical centers of Protestantism.

  12. Violência contra as mulheres no trabalho: O caso do assédio sexual

    OpenAIRE

    Dias, Isabel

    2008-01-01

    No presente artigo analisa-se o assédio sexual como sendo uma das formas mais graves de violência praticada contra as mulheres no contexto do trabalho. Identificam-se os factores de risco e as vítimas mais vulneráveis. Estuda-se as consequências do assédio para as vítimas e no contexto organizacional onde ele ocorre. Problematiza-se o assédio no continuum de violência geral experimentada pelas mulheres. This article analyses sexual harassment as one of the most harmful forms of violence ag...

  13. Tutela jurídica do empregado em face de assédio moral

    OpenAIRE

    Xerez, Lena Marcílio

    2013-01-01

    O assédio moral pode ser definido como a conduta abusiva, praticada por empregador, preposto deste ou empregado, de forma repetida e sistemática, que configure violência psicológica por atentar contra a dignidade de empregado ou grupo de empregados, resultando na degradação do ambiente de trabalho. Conforme a relação hierárquica entre o agressor e a vítima, o assédio moral pode ser classificado como vertical, horizontal e misto. O assédio moral vertical é praticado entre sujeitos de níveis hi...

  14. IDENTIFICAÇÃO DE ASSÉDIO MORAL EM PROFESSORES UNIVERSITÁRIOS

    OpenAIRE

    Teixeira, Nely Raquel Moroz

    2014-01-01

    O Assédio Moral é considerado um tipo de violência psicológica que atinge as empresas de um modo geral e que está contaminando e se alastrando nas instituições de ensino superior, prejudicando aspectos psicopedagógicos e relacionais nessas organizações. Esta pesquisa teve o objetivo de verificar a ocorrência de assédio moral em professores universitários e identificar os tipos de assédio moral sofridos pelos mesmos: por parte do empregador ou descendente, dos colegas ou horizontal e de alunos...

  15. Operational safety and radioprotection considerations when designing the ILW-LL disposal zone

    International Nuclear Information System (INIS)

    Voinis, S.; Roulet, A.; Claudel, D.; Lesavre, A.

    2008-01-01

    As for any other nuclear industrial facility, in a radioactive waste repository the various waste disposal operational activities from construction to closure can present a risk to human (workers and public) and the environment. In accordance with the December 30, 1991 French Waste Act, Andra has conducted feasibility studies regarding the disposal of HLW and ILW-LL waste in a clay host formation. The 'Dossier 2005 - Clay' includes a description of the operational safety analysis that was conducted for ILW-LL waste disposal in underground horizontal drifts. The objective of this paper is to present that safety analysis and its impact on the design at the feasibility stage. The safety analysis covered the operations from the reception of the waste transport casks to the disposal of the waste disposal package in its final emplacement location inside the disposal cell. Since the surface facilities' operations are similar to those of other nuclear ones, this paper focuses on the specificity of the deep repository, i.e. the operational safety and radioprotection aspects applied to the deep disposal drift. Andra has selected an ILW-LL design based on large horizontal drifts (diameters of 10 to 12 m, and lengths of 250 m). The primary waste packages are put inside a specific concrete overpack before their disposal. These overpacks are remotely stacked inside the horizontal drifts. The operational safety analysis aims to ensure that risks are kept under control through provisions in the design of the repository and by operating the facility in compliance with operational requirements and the safety functions. The requirements and the safety functions, developed at this stage of the feasibility studies, will be explained. The operational safety analysis is structured around physical components and real activities (construction, operation, closure) through a dedicated risk analysis. Due to the large variety of different ILW-LL waste, in order to identify the potential

  16. Demanda e desemprego no médio prazo

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo de Castro Soromenho

    2008-12-01

    Full Text Available Apresentamos um modelo keynesiano no qual o conceito tradicional de equilíbrio do mercado de trabalho é substituído por um jogo evolucionário. O modelo permite concluir que, ao contrário da análise tradicional, a demanda agregada é crucial para determinar o nível de emprego de médio prazo. Mostramos que, ao alterarem a parametrização da dinâmica evolucionária, a política econômica e o gasto autônomo geram bifurcações, caracterizadas por mudanças no número de equilíbrios e/ou nas propriedades de estabilidade. O desemprego passa a ser compreendido não como resultado de uma rigidez nominal ad hoc, mas sim como uma propriedade emergente da interação entre agentes que buscam a melhor estratégia de barganha salarial em um ambiente de racionalidade limitada.In this article, we propose a keynesian model in which the traditional labor market equilibrium is replaced by an evolutionary game. In such a model the aggregate demand plays the crucial role in the determination of the medium-run equilibrium, differently from the traditional analysis. We show that economic policy and autonomous spending generate bifurcations, characterized by changes in the number of equilibria and/or in the stability properties. Thus, unemployment is not a result of an ad hoc nominal rigidity, but arises as a spontaneous outcome of an interaction process in which bounded rational agents grope for the best wage bargaining strategy.

  17. Duplication of Dio3 genes in teleost fish and their divergent expression in skin during flatfish metamorphosis.

    Science.gov (United States)

    Alves, R N; Cardoso, J C R; Harboe, T; Martins, R S T; Manchado, M; Norberg, B; Power, D M

    2017-05-15

    Deiodinase 3 (Dio3) plays an essential role during early development in vertebrates by controlling tissue thyroid hormone (TH) availability. The Atlantic halibut (Hippoglossus hippoglossus) possesses duplicate dio3 genes (dio3a and dio3b). Expression analysis indicates that dio3b levels change in abocular skin during metamorphosis and this suggests that this enzyme is associated with the divergent development of larval skin to the juvenile phenotype. In larvae exposed to MMI, a chemical that inhibits TH production, expression of dio3b in ocular skin is significantly up-regulated suggesting that THs normally modulate this genes expression during this developmental event. The molecular basis for divergent dio3a and dio3b expression and responsiveness to MMI treatment is explained by the multiple conserved TREs in the proximal promoter region of teleost dio3b and their absence from the promoter of dio3a. We propose that the divergent expression of dio3 in ocular and abocular skin during halibut metamorphosis contributes to the asymmetric pigment development in response to THs. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Chapa aglomerada de cimento-madeira de Hevea brasiliensis Müll. Arg. Cement-bonded particleboard of Hevea brasiliensis Müll. Arg.

    Directory of Open Access Journals (Sweden)

    Esmeralda Yoshico Arakaki Okino

    2004-06-01

    Full Text Available Chapas de partículas de cimento-madeira foram confeccionadas com a madeira de quatro clones de Hevea brasiliensis Müll. Arg. (seringueira: IAN 717, IAN 873, GT 711 e AVROS 1301. Confeccionaram-se as chapas na proporção de 1:4:1 (madeira:cimento:água por peso e nas dimensões de 450 x 450 x 13 mm e densidade nominal de 1,4 g/cm³, com a adição de 4% de cloreto de cálcio di-hidratado (CaCl2.2H2O como acelerador. Foram testadas partículas fervidas e não-fervidas dos quatro clones, totalizando oito tratamentos, sendo em cada um destes, com quatro repetições, avaliadas as propriedades mecânicas e físicas das chapas, segundo a norma ASTM D 1037 - 96a. De forma geral, os melhores resultados de propriedades físicas e mecânicas foram obtidos nas chapas com partículas do clone AVROS 1301. No teste de hidratação do cimento, a madeira de seringueira in natura foi classificada como de "inibição extrema", porém com a adição de CaCl2 o foi como de "baixa inibição". Essa madeira se mostrou tecnicamente viável à produção de chapas de cimento-madeira, independentemente do clone.Cement-bonded particleboards of rubberwood were manufactured with four clones of Hevea brasiliensis Müll. Arg. (rubberwood: IAN 717, IAN 873, GT 711 and AVROS 1301. Boards of 450 x 450 x 13 mm were manufactured in a ratio of 1:4:1 (wood/cement/water, weight basis, with 1.4 g/cm³ density and 4% calcium chloride dihydrated - CaCl2.2H2O as accelerator. The particles of four clones were tested in treated and untreated conditions, totaling eight treatments. In each treatment with four replicates, the physical and mechanical properties were evaluated according to ASTM D 1037 - 96a standard. Overall, the best mechanical and physical results were obtained with the cement-bonded particleboard made with particles from clone AVROS 1301. Rubberwood has shown to be "highly inhibitory" in the hydration test, however when CaCl2 was added the inhibition index decreased and

  19. Young asteroid mixing revealed in ordinary chondrites: The case of NWA 5764, a polymict LL breccia with L clasts

    Science.gov (United States)

    Gattacceca, Jérome; Krzesińska, Agata M.; Marrocchi, Yves; Meier, Matthias M. M.; Bourot-Denise, Michèle; Lenssen, Rob

    2017-11-01

    Polymict chondritic breccias—rocks composed of fragments originating from different chondritic parent bodies—are of particular interest because they give insights into the mixing of asteroids in the main asteroid belt (occurrence, encounter velocity, transfer time). We describe Northwest Africa (NWA) 5764, a brecciated LL6 chondrite that contains a >16 cm3 L4 clast. The L clast was incorporated in the breccia through a nondestructive, low-velocity impact. Identical cosmic-ray exposure ages of the L clast and the LL host (36.6 ± 5.8 Myr), suggest a short transfer time of the L meteoroid to the LL parent body of 0.1 ± 8.1 Myr, if that meteoroid was no larger than a few meters. NWA 5764 (together with St. Mesmin, Dimmitt, and Glanerbrug) shows that effective mixing is possible between ordinary chondrite parent bodies. In NWA 5764 this mixing occurred after the peak of thermal metamorphism on the LL parent body, i.e., at least several tens of Myr after the formation of the solar system. The U,Th-He ages of the L clast and LL host, identical at about 2.9 Ga, might date the final assembly of the breccia, indicating relatively young mixing in the main asteroid belt as previously evidenced in St. Mesmin.

  20. Ensino de Astronomia no Ensino Médio

    Science.gov (United States)

    Albrecht, E.; Voelzke, M. R.

    2008-09-01

    O presente trabalho de intervenção foi realizado junto a Escola Estadual Colônia dos Pescadores na cidade de Caraguatatuba, com três turmas do terceiro ano do Ensino Médio, envolvendo 119 alunos, 40 na turma A, 40 na turma B e 39 na turma C. A fase inicial foi composta de um questionário de vinte questões dissertativas e objetivas para diagnosticar nos educandos os conceitos prévios sobre Astronomia e, partindo destes realizar uma interferência nas classes envolvidas utilizando metodologias diferentes sendo elas: a tradicional, onde o professor é um repassador de informações, fazendo uso exclusivo de lousa e giz; a segunda também de forma tradicional, porém com auxílio de multimídia para desenvolvimento das aulas e a terceira sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervenções necessárias. Ao final do trabalho as mesmas turmas da fase inicial orientadas pelo mesmo professor responderam novamente ao questionário proposto para diagnosticar dentre as três metodologias utilizadas qual apresentou melhores resultados, sendo os iniciais comparados com os finais. Quando questionados a respeito do significado de Astronomia observou-se inicialmente que os acertos na turma A foram de 100%,turma B: 64%, turma C: 84%, após a intervenção os acertos foram: 100%, 97% e 85% respectivamente, demonstrando claramente uma absorção de conhecimentos. Quando interrogados sobre quantos planetas você acha que existem em nosso Sistema Solar? os acertos foram: turma A: 39%, turma B: 48% e turma C: 46%, após o desenvolvimento do trabalho os acertos foram 94%, 97% e 90% respectivamente.Dentro das respostas obtidas observa-se que a metodologia tradicional com o auxílio de multimeios, aplicada na turma B, demonstrou melhores resultados, foi a mais significativa.

  1. Influência de frações da parede celular de levedura (Saccharomyces cerevisiae sobre os índices séricos de glicose e lipídios, microbiota intestinal e produção de ácidos graxos voláteis (AGV de cadeias curtas de ratos em crescimento Influence of yeast (Saccharomyces cerevisiae cell wall fractions on serum indexes of glucose and lipids, intestinal microbiota and production of short-chain volatile fatty acids (VFA in growing rats

    Directory of Open Access Journals (Sweden)

    Saula Goulart Chaud

    2007-06-01

    Full Text Available Os índices séricos de glicose e lipídios, a microbiota intestinal e a produção de ácidos graxos voláteis de cadeias curtas (AGV foram determinados em ratos Wistar submetidos às dietas: padrão (AIN-P, padrão modificada (AIN-M e às dietas contendo frações de parede celular de levedura: glicana insolúvel (GI, manana (M e glicana mais manana (G+M, como única fonte de fibra alimentar. O fracionamento da parede celular (PC foi realizado por processos físicos e químicos de extração, centrifugação e secagem em "spray dryer". Os índices séricos foram dosados através de "kits" comerciais. A microbiota e a produção de AGV foram determinadas nos conteúdos intestinais, incluindo cólon, ceco e reto. Considerando os níveis de colesterol no tempo (T0 e no tempo 28 (T28, as dietas AIN-P, AIN-M e M apresentaram efeito hipocolesterolêmico, tendo em vista que a composição das dietas eram de natureza hipercolesterolêmica. Em relação à glicose sérica, no tempo (T0 observou-se uma elevação geral da glicemia, sugerindo um efeito hiperglicêmico das dietas estudadas. A dieta G+M foi a que apresentou valores significantemente mais elevados de lipídios séricos no tempo T14, e os níveis mais baixos foram observados na dieta M e na dieta GI no T14 e nas dietas AIN-M e AIN-P. A dieta AIN-P foi a que apresentou valor significantemente mais elevado de triacilgliceróis nos tempos T14 e T28. Os níveis mais baixos nos tempos T14 foram constatados para as dietas G+M e GI e no tempo T28 para as dietas AIN-M e M. De um modo geral, não houve modificações significativas na microbiota intestinal dos animais em nenhuma das dietas. Dentre os AGV, o ácido acético foi o predominante, seguido do propiônico e do butírico, em todas as dietas estudadas.The blood serum indexes of glucose and lipids, the intestinal microbiota and the production of volatile fatty acids (VFA were determined in Wistar rats which were fed a standard (AIN-P diet, a

  2. LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction.

    Science.gov (United States)

    Kishi, Masashi; Kummer, Terrance T; Eglen, Stephen J; Sanes, Joshua R

    2005-04-25

    In both neurons and muscle fibers, specific mRNAs are concentrated beneath and locally translated at synaptic sites. At the skeletal neuromuscular junction, all synaptic RNAs identified to date encode synaptic components. Using microarrays, we compared RNAs in synapse-rich and -free regions of muscles, thereby identifying transcripts that are enriched near synapses and that encode soluble membrane and nuclear proteins. One gene product, LL5beta, binds to both phosphoinositides and a cytoskeletal protein, filamin, one form of which is concentrated at synaptic sites. LL5beta is itself associated with the cytoplasmic face of the postsynaptic membrane; its highest levels border regions of highest acetylcholine receptor (AChR) density, which suggests a role in "corraling" AChRs. Consistent with this idea, perturbing LL5beta expression in myotubes inhibits AChR aggregation. Thus, a strategy designed to identify novel synaptic components led to identification of a protein required for assembly of the postsynaptic apparatus.

  3. Influence of continuous illumination on estrous cycle of rats: time course of changes in levels of gonadotropins and ovarian steroids until occurrence of persistent estrus.

    Science.gov (United States)

    Takeo, Y

    1984-08-01

    Plasma concentrations of LH, FSH, 17 beta-estradiol, estrone and progesterone were determined chronologically by radioimmunoassays in two groups of adult female rats exposed to continuous illumination (LL). Group 1 rats showing vaginal estrous cycles were sacrificed at 3- to 6-hour intervals during late proestrus through early estrus of the first 5 cycles after exposure to LL. Group 2 animals which displayed persistent vaginal estrus in an early period of exposure to LL were killed on the 2nd, 3rd, 4th, 5th and 7th days of vaginal estrus. In Group 1 rats, surges of the hormones, except estrone, took place in all the 5 cycles. The occurrence of peak hormone levels in each cycle was invariably delayed after transfer of animals to LL. According to regression analyses, the lengths of secretion cycles of LH, FSH, 17 beta-estradiol and progesterone in rats under LL were 100.89, 100.46, 101.14 and 101.06 h, respectively. Elevation of 17 beta-estradiol levels was observed prior to the LH surge, and peaks of progesterone and FSH occurred following it. However, the secretion patterns of these hormones appear to be disrupted with length of exposure to LL. In group 2 rats, the mean concentration of LH during persistent estrus was approximately similar to that on the morning of the days of proestrus of the 4-day cycles of rats placed under an alternating 12-hour light-dark regimen (LD), whereas the mean FSH concentration was continuously low. While the concentrations of 17 beta-estradiol and estrone in persistent-estrous rats were elevated, progesterone levels remained low.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Lactobacillus delbrueckii bakteriyofajı LL-H'nin konakçı spektrumu

    OpenAIRE

    Gökçe, Özge

    2010-01-01

    Bu çalışmada, 7 Lactobacillus delbrueckii ssp. lactis, 6 Lactobacillus delbrueckii ssp. bulgaricus ve 5 Lactobacillus helveticus suşu kullanılarak Lactobacillus delbrueckii bakteriyofajı LL-H'nin konakçı spektrumu incelenmiştir. Her bir suş için çift tabakalı plak titresi (double-layer plaque assay) yöntemi kullanılarak en az 2 tekrar ile adsorbsiyon kinetiği incelenmiştir. Adsorbsiyon kinetiğini incelemek için 0, 3, 10, 30 ve 50. dakikalar dikkate alınarak adsorbsiyon eğrileri oluşturulmuştu...

  5. Chapa aglomerada de cimento-madeira de Hevea brasiliensis Müll. Arg.

    OpenAIRE

    Okino,Esmeralda Yoshico Arakaki; Souza,Mário Rabelo de; Santana,Marcos Antonio Eduardo; Sousa,Maria Eliete de; Teixeira,Divino Eterno

    2004-01-01

    Chapas de partículas de cimento-madeira foram confeccionadas com a madeira de quatro clones de Hevea brasiliensis Müll. Arg. (seringueira): IAN 717, IAN 873, GT 711 e AVROS 1301. Confeccionaram-se as chapas na proporção de 1:4:1 (madeira:cimento:água) por peso e nas dimensões de 450 x 450 x 13 mm e densidade nominal de 1,4 g/cm³, com a adição de 4% de cloreto de cálcio di-hidratado (CaCl2.2H2O) como acelerador. Foram testadas partículas fervidas e não-fervidas dos quatro clones, totaliza...

  6. 27-day cycles in human mortality: Traute and Bernhard Düll

    Science.gov (United States)

    Halberg, F.; Düll-Pfaff, N.; Gumarova, L.; Zenchenko, T. A.; Schwartzkopff, O.; Freytag, E. M.; Freytag, J.; Cornelissen, G.

    2013-04-01

    This tribute to her parents by one co-author (NDP) is the fruit of a more than a decade-long search by the senior author (FH) for the details of the lives of Bernhard and Gertraud (''Traute'') Düll. These pioneers studied how space/terrestrial weather may differentially influence human mortality from various causes, the 27-day mortality pattern being different whether death was from cardiac or respiratory disease, or from suicide. FH is the translator of personal information about her parents provided by NDP in German. Figuratively, he also attempts to ''translate'' the Dülls' contribution in the context of the literature that had appeared before their work and after their deaths. Although the Dülls published in a then leading journal, among others (and FH had re-analyzed some of their work in a medical journal), they were unknown to academies or libraries (where FH had inquired about them). The Dülls thoroughly assembled death certificates to offer the most powerful evidence for an effect of solar activity reflected in human mortality, as did others before them. They went several steps further than their predecessors, however. They were the first to show possibly differential effects of space and/or Earth weather with respect to suicide and other deaths associated with the nervous and sensory systems vs. death from cardiac or respiratory disease as well as overall death by differences in the phase of a common 27-day cycle characterizing these mortality patterns. Furthermore, Bernhard Düll developed tests of human visual and auditory reaction time to study effects of weather and solar activity, publishing a book (his professorial dissertation) on the topic. His unpublished finding of an increased incidence of airplane crashes in association with higher solar activity was validated after his death, among others, by Tatiana Zenchenko and A. M. Merzlyi.

  7. 27-day cycles in human mortality: Traute and Bernhard Düll

    Directory of Open Access Journals (Sweden)

    F. Halberg

    2013-04-01

    Full Text Available This tribute to her parents by one co-author (NDP is the fruit of a more than a decade-long search by the senior author (FH for the details of the lives of Bernhard and Gertraud (''Traute'' Düll. These pioneers studied how space/terrestrial weather may differentially influence human mortality from various causes, the 27-day mortality pattern being different whether death was from cardiac or respiratory disease, or from suicide. FH is the translator of personal information about her parents provided by NDP in German. Figuratively, he also attempts to ''translate'' the Dülls' contribution in the context of the literature that had appeared before their work and after their deaths. Although the Dülls published in a then leading journal, among others (and FH had re-analyzed some of their work in a medical journal, they were unknown to academies or libraries (where FH had inquired about them. The Dülls thoroughly assembled death certificates to offer the most powerful evidence for an effect of solar activity reflected in human mortality, as did others before them. They went several steps further than their predecessors, however. They were the first to show possibly differential effects of space and/or Earth weather with respect to suicide and other deaths associated with the nervous and sensory systems vs. death from cardiac or respiratory disease as well as overall death by differences in the phase of a common 27-day cycle characterizing these mortality patterns. Furthermore, Bernhard Düll developed tests of human visual and auditory reaction time to study effects of weather and solar activity, publishing a book (his professorial dissertation on the topic. His unpublished finding of an increased incidence of airplane crashes in association with higher solar activity was validated after his death, among others, by Tatiana Zenchenko and A. M. Merzlyi.

  8. [Morphological recovery in the polycystic ovaries of persistent-estrus rats induced by continuous illumination (author's transl)].

    Science.gov (United States)

    Sawada, T; Kosaka, T

    1981-10-01

    When mature female rats having been showing at least 2 consecutive 4-day estrous cycles were raised in a room with continuous lighting (LL), their vaginal smear pattern became irregular by 7 to 9 days. and a persistent-estrus (P-E) appeared around 25 to 75 days of exposure. Ovaries from LL-exposed rats showing irregular cycles or P-E had signs of cystic follicles and anovulatory polycystic follicles, respectively. When P-E rats were placed again under the light-dark cycling condition (14L: 10D; Lights on 05: 00 h), the regular 4-day cycles were recovered soon and ovarian structures became normal after about 5 cycles. In P-E rats injected i.v. with 10 microgram LH/day at 4-day intervals under the LL condition, the regular estrous cycle reappeared and ovarian structures became normal after 5 administrations. These results suggest that the polycystic ovary of P-E rat induced by LL is reversible with cyclic stimulation by LH.

  9. Ontogenia e estrutura do pericarpo de Prestonia riedelii (Müll. Arg. Markgr. (Apocynaceae Pericarp ontogeny and structure of Prestonia riedelii (Müll. Arg. Markgr. (Apocynaceae

    Directory of Open Access Journals (Sweden)

    Shesterson Aguiar

    2009-09-01

    Full Text Available O trabalho teve por objetivos descrever a ontogenia e estrutura do pericarpo de P. riedelii, visando fornecer subsídios aos trabalhos taxonômicos, filogenéticos e ecológicos realizados para família. Flores e frutos em diferentes estádios de desenvolvimento foram fixados em FAA, incluídos em resina plástica, seccionados com 10 ìm e corados com azul de toluidina para análise estrutural. O fruto de P. riedelii é um folicarium, sendo formado por dois frutículos do tipo folículo. O epicarpo, originado da epiderme externa do ovário, é formado por uma camada de células epidérmicas de cutícula espessa e tricomas tectores multicelulares e unisseriados. O mesocarpo, originado a partir do desenvolvimento do tecido fundamental, é formado por várias camadas de células parenquimáticas, feixes vasculares, fibras não lignificadas e laticíferos. O endocarpo sensu lato é formado por duas camadas de esclerócitos de disposição cruzada, que se originam da epiderme interna do ovário e de uma camada de células do tecido fundamental. A deiscência de cada folículo é marginal e o processo de deiscência envolve um conjunto de características anatômicas, como células de parede delgada e sinuosa formando a linha de deiscência, fibras não lignificadas no mesocarpo e esclerócitos de disposição cruzada no endocarpo.The aim of this work was to describe the morphology and ontogeny of P. riedelii fruits to aid in taxonomic, ecological and phylogenetic studies in Apocynaceae. Fruits were fixed in FAA, embedded in plastic resin, sectioned at 10 ìm and stained with toluidine blue, for structural analysis. The fruit of P. riedelii is a follicarium, with two follicular fruitlets. The epicarp is one-cell-layered, with trichomes and thick cuticle. The mesocarp, originating from fundamental ovary tissue, is parenchymatous with laticifers, non-lignified fibers and vascular bundles. The endocarp sensu lato is two-celllayered of crossed sclereids

  10. dio comunitária e liberdade de expressão no Brasil

    OpenAIRE

    Peruzzo, Cicilia M. Krohling; Volpato, Marcelo de Oliveira

    2010-01-01

    Uma das formas de exercer tal direito tem se tornado possível, no Brasil, nos últimos anos, pelas rádios comunitárias. Quando uma rádioS comunitária está efetivamente sob o controle das comunidades e de seus aliados, promovendo e viabilizando a participação popular, ou seja, mobilizando os cidadãos para atuação como repórteres, red atores, técnicos de som, sonoplastas, editores, locutores ou, em níveis mais avançados, como cogestores de uma rádio comunitária, inicia-se a construção de um proc...

  11. A Reação ao Assédio Moral no ambiente do trabalho

    Directory of Open Access Journals (Sweden)

    Míriam Rodrigues

    2013-06-01

    Full Text Available Este estudo se propõe a agrupar características de profissionais que reagem aoassédio moral no ambiente de trabalho. Os estudos sobre este tema, ainda recentes,e também sua importância, sinalizam a necessidade de maior aprofundamento nacompreensão deste fenômeno tão nocivo para profissionais e organizações. O uso daanálise de agrupamentos ou clusters propiciou novas possibilidades de entendimentodo fenômeno. Foram analisadas respostas oferecidas por 175 profissionais deempresas de diferentes ramos e portes a um formulário com questões abertas. Osresultados indicaram que a reação ao assédio, na amostra em questão, ocorre entrea liderança média quando sofre assédio da liderança mais alta.

  12. Riscos psicossociais e assédio moral no contexto acadêmico

    OpenAIRE

    Vânia Cláudia Spoti Caran

    2007-01-01

    O Assédio Moral e os riscos psicossociais tem sido fonte de estudos de diversos pesquisadores no século XXI, mas ainda é pouco abordado pela Saúde do Trabalhador. Assédio Moral é tema complexo, de difícil abordagem, pois está inserido em um âmbito da violência caracterizada pela percepção muitas vezes apenas da própria vítima. Nesta pesquisa estabelecemos os objetivos de identificar a existência de Riscos Pscicossociais e Assédio Moral e suas repercussões entre os docentes de uma Instituição ...

  13. Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats.

    Science.gov (United States)

    Seoane-Collazo, Patricia; Martínez de Morentin, Pablo B; Fernø, Johan; Diéguez, Carlos; Nogueiras, Rubén; López, Miguel

    2014-05-01

    Nicotine, the main addictive component of tobacco, promotes body weight reduction in humans and rodents. Recent evidence has suggested that nicotine acts in the central nervous system to modulate energy balance. Specifically, nicotine modulates hypothalamic AMP-activated protein kinase to decrease feeding and to increase brown adipose tissue thermogenesis through the sympathetic nervous system, leading to weight loss. Of note, most of this evidence has been obtained in animal models fed with normal diet or low-fat diet (LFD). However, its effectiveness in obese models remains elusive. Because obesity causes resistance towards many factors involved in energy homeostasis, the aim of this study has been to compare the effect of nicotine in a diet-induced obese (DIO) model, namely rats fed a high-fat diet, with rats fed a LFD. Our data show that chronic peripheral nicotine treatment reduced body weight by decreasing food intake and increasing brown adipose tissue thermogenesis in both LFD and DIO rats. This overall negative energy balance was associated to decreased activation of hypothalamic AMP-activated protein kinase in both models. Furthermore, nicotine improved serum lipid profile, decreased insulin serum levels, as well as reduced steatosis, inflammation, and endoplasmic reticulum stress in the liver of DIO rats but not in LFD rats. Overall, this evidence suggests that nicotine diminishes body weight and improves metabolic disorders linked to DIO and might offer a clear-cut strategy to develop new therapeutic approaches against obesity and its metabolic complications.

  14. Siim Nestor soovitab : uute eesti plaatide esitlusõhtud! Metro Luminal. Lu : K. Metsatöll / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2004-01-01

    Rockansambli Metro Luminal plaadi "Reboot" esitlusest Tartu Sadamateatris 9. dets. ja Rock Café's Tallinnas 10. dets.(kaasa teeb DJ Sing). Popansambli Lu:k albumist "Raadiomaja valvelauas" ja ansambli 10. aastapäeva tähistamisest 10. dets. Tallinnas Kunstiakadeemia saalis. Ansambli Metsatöll albumi "Hiiekoda" esitlusest 11.dets. Rock Café's Tallinnas

  15. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.

    Science.gov (United States)

    Tada, Hiroyuki; Shimizu, Takamitsu; Nagaoka, Isao; Takada, Haruhiko

    2016-01-01

    Maxacalcitol (22-oxacalcitriol: OCT) is a synthetic vitamin D3 analog with a limited calcemic effect. In this study, we investigated whether OCT increases the production of LL-37/CAP-18, a human cathelicidin antimicrobial peptide, in human gingival/oral epithelial cells. A human gingival epithelial cell line (Ca9-22) and human oral epithelial cell lines (HSC-2, HSC-3, and HSC-4) exhibited the enhanced expression of LL-37 mRNA upon stimulation with OCT as well as active metabolites of vitamins D3 and D2. Among the human epithelial cell lines, Ca9-22 exhibited the strongest response to these vitamin D-related compounds. OCT induced the higher production of CAP-18 (ng/mL order) until 6 days time-dependently in Ca9-22 cells in culture. The periodontal pathogen Porphyromonas gingivalis was killed by treatment with the LL-37 peptide. These findings suggest that OCT induces the production of hCAP-18/LL-37 in a manner similar to that induced by the active metabolite of vitamin D3.

  16. I'll Save the World from Global Warming--Tomorrow: Using Procrastination Management to Combat Global Warming

    Science.gov (United States)

    Malott, Richard W.

    2010-01-01

    In the provocatively titled "I'll Save the World from Global Warming--Tomorrow," Dick Malott says that although we all want to do the right thing to help the environment, whether it's buying and installing compact fluorescent light bulbs (CFLs) or replacing an energy-guzzling appliance with a more efficient one, we put it off because there's no…

  17. Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infections

    DEFF Research Database (Denmark)

    Nielsen, Karen L; Dynesen, Pia; Larsen, Preben

    2014-01-01

    Cathelicidin (LL-37) and human β-defensin 1 (hBD-1) are important components of the innate defense in the urinary tract. The aim of this study was to characterize whether these peptides are important for developing uncomplicated Escherichia coli urinary tract infections (UTIs). This was investiga......Cathelicidin (LL-37) and human β-defensin 1 (hBD-1) are important components of the innate defense in the urinary tract. The aim of this study was to characterize whether these peptides are important for developing uncomplicated Escherichia coli urinary tract infections (UTIs......). This was investigated by comparing urinary peptide levels of UTI patients during and after infection to those of controls, as well as characterizing the fecal flora of participants with respect to susceptibility to LL-37 and in vivo virulence. Forty-seven UTI patients and 50 controls who had never had a UTI were...... included. Participants were otherwise healthy, premenopausal, adult women. LL-37 MIC levels were compared for fecal E. coli clones from patients and controls and were also compared based on phylotypes (A, B1, B2, and D). In vivo virulence was investigated in the murine UTI model by use of selected fecal...

  18. Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells

    NARCIS (Netherlands)

    Liu, Quan; Liu, Juan; Roschmann, Kristina Irene Lisolette; van Egmond, Danielle; Golebski, Korneliusz; Fokkens, Wytske Johanna; Wang, Dehui; van Drunen, Cornelis Maria

    2013-01-01

    HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely

  19. Suicídio na infância e adolescência

    OpenAIRE

    Kuczynski, Evelyn

    2014-01-01

    O presente ensaio é a transcrição da aula ministrada durante a II Jornada sobre Suicídio do Laboratório de Estudos sobre a Morte, ocorrida em 22 de maio de 2013 (Brasil). Propõe-se a abordar aspectos históricos e epidemiológicos do suicídio na infância e na adolescência, além de se concentrar nas abordagens preconizadas para este fenômeno. This essay is the transcription of a class given during the II Workshop on Suicide of ...

  20. Influências do Ensino Médio nas perspectivas de futuro de seus estudantes

    OpenAIRE

    Wender Faleiro; Roberto Valdes Puentes; Milena Cristina Aragão

    2016-01-01

    O presente estudo objetivou conhecer a percepção que os estudantes do Ensino Médio de Uberlândia, MG possuem sobre a influência da escola em suas vidas. O estudo foi realizado em sete escolas, com 1.040 alunos de todos os três níveis de seriação do Ensino Médio. Para a maioria dos alunos entrevistados a escola representa algum tipo de mudança positiva e, para muitos, a única finalidade da escola é melhorar as possibilidades de empregabilidade. Por outro lado, muitos demonstram estarem mais co...

  1. Hacia una teología personalista del Reino de Dios

    OpenAIRE

    Alviar, J.J. (J. José)

    2004-01-01

    SUMARIO: A. LOS DATOS BÍBLICOS. 1. Revelación bíblica sobre el Reino, como relación entre Dios y los hombres. a) Reino, Pueblo, Alianza en el Antiguo Testamento. i) Señorío divino, obediencia humana. ii) Esperanzas del exilio: restauración y futura gloria de Israel. iii) Esperanzas del postexilio: hacia un reino escatológico. iv) La esperanza mesiánica. b) El Reino de Dios llega con Cristo. i) La revelación del Reino en las palabras y acciones de Jesucristo. ii) La articulación...

  2. A estrutura do conhecimento nas universidades ocidentalizadas: racismo/sexismo epistêmico e os quatro genocídios/epistemicídios do longo século XVI

    Directory of Open Access Journals (Sweden)

    Ramón Grosfoguel

    2016-04-01

    Full Text Available Este artigo discute a estrutura epistêmica do mundo moderno em relação aos quatro genocídios/epistemicídios do longo século XVI (1450-1650. Argumenta-se que o privilégio epistêmico do homem ocidental foi construído às custas do genocídio/epistemicídios dos sujeitos coloniais. O artigo relaciona o racismo/sexismo epistêmico da estrutura das universidades ocidentalizadas e do mundo moderno ao genocídio/epistemicídio contra muçulmanos e judeus na conquista de Al-Andalus, contra povos nativos na conquista das Américas, contra povos africanos na conquista da África e a escravização dos mesmos nas Américas e, finalmente, contra as mulheres europeias queimadas vivas acusadas de bruxaria. Esses quatro genocídios/epistemicídios são fundantes da estrutura epistêmica moderno-colonial e das universidades ocidentalizadas. A tese principal deste artigo é que a condição de possibilidade para o cartesianismo idolátrico dos anos 1640 que assume o olho de Deus e arroga-se o direito de dizer "penso, logo existo" é o "extermino, logo existo".

  3. Viabilidade de escleródios de Sclerotinia sclerotiorum e incidência de fungos antagonistas em solo de Cerrado

    Directory of Open Access Journals (Sweden)

    Leila de Castro Louback Ferraz

    2011-12-01

    Full Text Available A viabilidade de escleródios de Sclerotinia sclerotiorum foi avaliada durante oito meses em três solos de Cerrado cultivados. Escleródios produzidos "in vitro", mantidos em invólucros de náilon perfurados, foram enterrados a 5 cm de profundidade, em solos previamente fumigados ou não fumigados com brometo de metila. Após 10 dias de incubação, os escleródios foram examinados quanto à viabilidade e a presença de fungos antagônicos. A viabilidade foi estimada através do número de escleródios germinados 7 dias após plaqueamento em meio semi seletivo Neon-S. A viabilidade dos escleródios variou com o solo de Cerrado. Escleródios incubados em solos não fumigados com brometo de metila apresentaram menor viabilidade e maior presença de fungos antagônicos, indicando que estes solos contêm elementos supressivos de origem biológica. A viabilidade dos escleródios foi relacionada negativamente com a população de alguns microorganismos de solo. Nos tratamentos de maior incidência de Trichoderma spp. observou-se menor viabilidade de escleródios e solos fumigados suprimiram fortemente a ocorrência deste antagonista.

  4. [Psychometric properties of Q-DIO, an instrument to measure the quality of documented nursing diagnoses, interventions and outcomes].

    NARCIS (Netherlands)

    Muller-Staub, M.; Lunney, M.; Lavin, M.A.; Needham, I.; Odenbreit, M.; Achterberg, T. van

    2010-01-01

    The instrument Q-DIO was developed in the years 2005 till 2006 to measure the quality of documented nursing diagnoses, interventions, and nursing sensitive patient outcomes. Testing psychometric properties of the Q-DIO (Quality of nursing Diagnoses, Interventions and Outcomes.) was the study aim.

  5. Criminologia, Antropologia e Medicina Legal. Um personagem central: Leonídio Ribeiro

    Directory of Open Access Journals (Sweden)

    Guilherme Gutman

    2010-09-01

    Full Text Available Apresentação da trajetória de Leonídio Ribeiro, em especial a sua abordagem do homossexualismo como representativa das concepções fundantes do campo da criminologia nas primeiras décadas do século XX no Brasil.

  6. Cultivares e estádios de Colheita no Rendimento Forrageiro da Soja

    Directory of Open Access Journals (Sweden)

    Pedro Milanez de Rezende

    2011-04-01

    Full Text Available Com o objetivo de verificar a influência do estádio de colheita sobre a produção e a qualidade do feno de duas cultivares de soja foi conduzido ensaio em Lavras, MG, no ano agrícola 2001/02. Utilizou-se o delineamento experimental de blocos casualizados, em esquema fatorial 2 x 5, com três repetições, compreendendo duas cultivares (Conquista e Monsoy 8400 e cinco estádios de corte (R2, R3, R4, R5 e R6. As cultivares afetaram apenas o rendimento de proteína do feno. Os maiores rendimentos de matéria seca, feno e proteínas foram obtidos com os cortes nos estádios R4, R5 e R6. Quanto ao rendimento de proteína bruta, verificou-se queda após o corte em R5. Esta redução, provavelmente, associada a efeito de estresse hídrico e ou diluição da proteína na matéria seca. O estádio de desenvolvimento R4 apresentou a melhor opção de corte para fenação, independentemente da cultivar. A cultivar Monsoy 8400 apresentou maior rendimento de proteína bruta que a cultivar Conquista.

  7. Retratos de autópsias Psicossociais sobre suicídio de idosos em Teresina

    Directory of Open Access Journals (Sweden)

    Selena Mesquita Teixeira Sérvio

    Full Text Available O desígnio da presente pesquisa consiste em analisar os fatores psicossociais que perpassaram o suicídio de idosos em Teresina, por meio de uma investigação retrospectiva dos aspectos da vida do suicida antes do autoextermínio e da reconstituição dos fatores de risco para o suicídio. Trata-se de uma pesquisa de natureza qualitativa, descritiva e exploratória. Foram construídas autópsias psicossociais de cinco casos de suicídios de idosos ocorridos no período de 2004 a 2009. Esse método reúne três tipos de informação: ficha de identificação pessoal e social, genograma e entrevista semi-estruturada. A coleta foi viabilizada pelo relato de cinco sujeitos, familiares e parentes próximos ao idoso. O material obtido passou por três etapas: pré-análise, análise qualitativa e síntese analítica. Desse modo, os principais fatores de risco associados ao suicídio desses idosos foram: depressão, transtornos mentais graves, estigma referente ao envelhecimento, alcoolismo, automutilações, impulsividade, relações afetivas fragilizadas e história de vida marcada por eventos trágicos.

  8. Os conteúdos de biologia celular no Exame Nacional do Ensino Médio - ENEM

    Directory of Open Access Journals (Sweden)

    Julio Sergio dos Santos

    2013-11-01

    Full Text Available O Exame Nacional do Ensino Médio vem se tornando um exame de extrema importância para avaliar os egressos do ensino médio. Isso porque ele seleciona estudantes para o ensino superior e contempla, em sua fundamentação a elaboração de competências e habilidades relacionadas a esse nível de ensino. O nosso estudo analisou a forma das questões exigidas pelo ENEM, bem como as habilidades avaliadas neste exame. De um total de 900 questões de diversas disciplinas, observamos 35 que continham algum conteúdo de biologia celular. Algumas dessas perguntas estavam associadas a diferentes disciplinas do ensino médio ou podiam exigir uma forte memorização de conteúdos específicos. Também foram encontradas questões que enfatizavam a resolução de problemas contextualizados, relacionados a fenômenos biológicos, mitigando, desse modo, o enfoque conteudista ou de conteúdo primado na aprendizagem no ensino médio.

  9. Sobre Dios y el mundo. Una autobiografía dialogada

    OpenAIRE

    Carabante, Josemaría; Spaemann, Robert

    2014-01-01

    Reseña del libro "Sobre Dios y el mundo. Una autobiografía dialogada" de Robert Spaemann, por Josemaría Carabante. Traducción: José María Barrio Maestre y Ricardo Barrio Moreno Palabra, Madrid. 2014, 396 págs

  10. Adjuvant and immunostimulatory effects of a D-galactose-binding lectin from Synadenium carinatum latex (ScLL in the mouse model of vaccination against neosporosis

    Directory of Open Access Journals (Sweden)

    Cardoso Mariana R D

    2012-10-01

    Full Text Available Abstract Vaccination is an important control measure for neosporosis that is caused by a coccidian parasite, Neospora caninum, leading to abortion and reproductive disorders in cattle and serious economic impacts worldwide. A D-galactose-binding lectin from Synadenium carinatum latex (ScLL was recently described by our group with potential immunostimulatory and adjuvant effects in the leishmaniasis model. In this study, we evaluated the adjuvant effect of ScLL in immunization of mice against neosporosis. First, we investigated in vitro cytokine production by dendritic cells stimulated with Neospora lysate antigen (NLA, ScLL or both. Each treatment induced TNF-α, IL-6, IL-10 and IL-12 production in a dose-dependent manner, with synergistic effect of NLA plus ScLL. Next, four groups of C57BL/6 mice were immunized with NLA + ScLL, NLA, ScLL or PBS. The kinetics of antibody response showed a predominance of IgG and IgG1 for NLA + ScLL group, whereas IgG2a response was similar between NLA + ScLL and NLA groups. Ex vivo cytokine production by mouse spleen cells showed the highest IFN-γ/IL-10 ratio in the presence of NLA stimulation for mice immunized with NLA + ScLL and the lowest for those immunized with ScLL alone. After parasite challenge, mice immunized with NLA + ScLL or ScLL alone presented higher survival rates (70-80% and lower brain parasite burden as compared to PBS group, but with no significant changes in morbidity and inflammation scores. In conclusion, ScLL combined with NLA was able to change the cytokine profile induced by the antigen or lectin alone for a Th1-biased immune response, resulting in high protection of mice challenged with the parasite, but with low degree of inflammation. Both features may be important to prevent congenital neosporosis, since protection and low inflammatory response are necessary events to guide towards a successful pregnancy.

  11. Pseudo-scalar Higgs boson production at N"3LO_A+N"3LL"'

    International Nuclear Information System (INIS)

    Ahmed, Taushif; Rana, Narayan; Ravindran, V.; Bonvini, Marco; Rottoli, Luca; Kumar, M.C.; Mathews, Prakash

    2016-01-01

    We consider the production of a pseudo-scalar particle A at the LHC, and present accurate theoretical predictions for its inclusive cross section in gluon fusion. The prediction is based on combining fixed-order perturbation theory and all-order threshold resummation. At fixed order we include the exact next-to-next-to-leading order (NNLO) plus an approximate next-to-next-to-next-to-leading order (N"3LO_A) which is based on the recent computation at this order for the scalar case. We then add threshold resummation at next-to-next-to-next-to leading logarithmic accuracy (N"3LL"'). Various forms of threshold resummation are considered, differing by the treatment of subleading terms, allowing a robust estimate of the theoretical uncertainties due to missing higher orders. With particular attention to pseudo-scalar masses of 200 and 750 GeV, we also observe that perturbative convergence is much improved when resummation is included. Additionally, results obtained with threshold resummation in direct QCD are compared with analogous results as computed in soft-collinear effective theory, which turn out to be in good agreement. We provide precise predictions for pseudo-scalar inclusive cross section at 13 TeV LHC for a wide range of masses. The results are available through updated versions of the public codes ggHiggs and TROLL. (orig.)

  12. Anatomia da madeira de Phyllanthus sellowianus Müll. Arg. (Phyllanthaceae

    Directory of Open Access Journals (Sweden)

    Luciano Denardi

    2013-01-01

    Full Text Available The present study aimed to describe the wood anatomy of Phyllanthus sellowianus Müll. Arg.(Phyllanthaceae, as well as the research of anatomical characters associated with the flexibility of their stems, desirable characteristic for bioengineering works. Belonging to the group of reophyllous and with up to three meters in height, the species occurs naturally in the south of Brazil, Uruguay and Argentina. The exsicat and wood sample from a P. sellowianus, located in the municipality of Santa Maria, Rio Grande do Sul state, Brazi, were deposited in the University Federal de Santa Maria under the numbers HDCF 5587 e 5588. Standard technique was used to set the histological lamina of wood. For macerations used the method of Jeffrey. The Wood anatomy description followed the IAWA Committee (1989. The microscopic analysis revealed the presence vassels of small diameter (< 60µm, radial multiples of 2 to 4 units, and simple perforation plates, obliquely, axial parenchyma absent, heterogeneous rays, with 1-3 cells large, and gelatinous fibers. The absence of axial parenchyma and laticifer tubes is compatible to the Phyllanthaceae group. The presence of perforated ray cells is, probably, the main anatomic component for differentiation of P. sellowianus from the other species of the genera. The abundant presence of gelatinous fibers certainly is one of the main anatomical characteristics related to the high flexibility of its stem.

  13. Representações sociais do suicídio pela comunidade de dormentes - PE

    Directory of Open Access Journals (Sweden)

    Sílvia Raquel Santos de Morais

    Full Text Available O fenômeno do suicídio representa um dos comportamentos humanos mais enigmáticos e perturbadores. Este estudo objetivou construir um mapeamento, por meio das representações sociais, dos fatores de risco quanto a esse fenômeno no Município de Dormentes - PE, em 2009. O interesse por essa investigação foi despertado pelo alto índice de suicídio na região. O estudo teve por base uma pesquisa de campo que envolveu a comunidade local, tais como familiares de suicidas, idosos, líderes comunitários, gestores e professores, totalizando 12 pessoas que responderam aos questionários e às entrevistas. Foi feito um levantamento sobre os casos de suicídio em Dormentes relativo ao período de 2006-2008 junto à polícia civil, ao cartório e à Secretaria de Saúde. Os resultados mostraram a ocorrência de 13 casos, predominando o enforcamento. As causas apontadas para o suicídio foram problemas pessoais e financeiros, falta de emprego, depressão, ansiedade, ciúme doentio, excesso de atividades, consanguinidade, falta de vitaminas e de uma alimentação adequada, excesso de remédios, profunda tristeza e vontade de acabar com o sofrimento, questões psicológicas e pensamentos repetitivos. Tal trabalho suscita inúmeras reflexões e constitui, também, um registro que poderá fazer parte do planejamento das políticas públicas do Município, especificamente no que se refere à saúde pública.

  14. O assédio moral na perspectiva de bancários

    Directory of Open Access Journals (Sweden)

    Lena Rodrigues Soares

    Full Text Available Este artigo discute o assédio moral nas instituições bancárias, tomando por base uma discussão conceitual do tema e um estudo empírico desenvolvido com funcionários de um banco da região Norte do Brasil. Tendo em vista uma delimitação teórico-conceitual, apresenta, com base em estudiosos consagrados na literatura, breve histórico da discussão sobre o fenômeno, bem como definições e características que o distinguem de outros conflitos recorrentes em ambientes de trabalho. Discute também o papel das organizações de trabalho quanto ao assédio. Apresenta ainda resultados de pesquisa realizada em agências bancárias durante os meses de julho, agosto e setembro de 2010 por meio de entrevistas individuais semiestruturadas, aplicadas a 37 voluntários que exerciam diferentes cargos nessas agências. Foi possível identificar que o assédio moral, como forma de violência, é um fenômeno reconhecido pelos bancários em seu ambiente de trabalho e que, em geral, os sujeitos associam o assédio moral à forma de gestão por pressão, focada em metas, produção e competitividade. Os resultados também incitam a reflexão de que é necessário tratar o assédio moral em uma perspectiva coletiva, como uma questão social, e não individual.

  15. ANÁLISE SENSORIAL DE QUEIJO MOZZARELLA COM REDUZIDO TEOR DE SÓDIO

    Directory of Open Access Journals (Sweden)

    Alessandra Broch

    2014-09-01

    Full Text Available O consumo excessivo de sal está diretamente relacionado ao desenvolvimento de doenças crônicas. As causas possíveis para o aumento da incidência da hipertensão arterial é o consumo de alimentos industrializados, enlatados, defumados, com processo de salga entre outros, o que leva ao consumo de grandes quantidades de sódio, maior do que o necessário para o corpo humano. O queijo mozzarella é o mais fabricado e consumido no Brasil e a fonte salina utilizada neste produto é o cloreto de sódio. Desta forma, este trabalho teve como objetivo elaborar quatro amostras de queijo mozzarella light com diferentes percentuais de redução de sódio (0, 12.7, 25.5 e 38.2% e avaliar a qualidade destas formulações sob aspectos físico- químicos e sensoriais. A avaliação sensorial foi realizada com 100 consumidores para os atributos cor, intensidade do sabor salgado, odor e textura do produto, utilizando escala hedônica de 9 pontos, e intenção de compra em uma escala de 3 pontos. Os dados foram avaliados por ANOVA e teste de Tukey.  O resultado obtido na análise sensorial indica que não há diferença significativa entre as amostras para todos os atributos avaliados (cor, sabor salgado, odor e textura. Assim, é viável em relação aos aspectos sensoriais estudados a redução de até 38.2% do teor de sódio para este tipo de produto, sendo que para o mesmo ser considerado light necessitamos de apenas 25% de redução do teor de sódio.

  16. DIO E CIDADANIA: um estudo comparado da atuação de rádios de Lisboa e de Brasília

    Directory of Open Access Journals (Sweden)

    Valquíria Guimarães da Silva

    2017-07-01

    Full Text Available É fundamental discutir o papel da mídia como um dos principais fóruns de discussão em sociedades democráticas. Neste trabalho analisamos a relação entre cidadania e rádio. A nossa intenção foi compreender como a rádio contribui para o entendimento de mundo indispensável à formação de opiniões sobre questões relevantes ao exercício da cidadania. Para isso estudámos as grades de programação de rádios em Lisboa e em Brasília, nos anos 2011 e 2012, e realizamos entrevistas com os respectivos diretores. Também realizamos grupos focais, no contexto de diversas organizações sociais, para compreender a relação dos cidadãos com a rádio. Observamos que a rádio continua a ter um grande potencial cívico, mas neste momento, de um modo geral, a sua programação pouco contribui para a promoção de uma cidadania efetiva.   PALAVRAS-CHAVE: Rádio; Cidadania; Democracia; Espaço Público; Jornalismo.   ABSTRACT It is essential to discuss the role of the media as one of the main debate forums in democratic societies. This research analyzes the relationship between citizenship and radio. Our intention was to comprehend how the radio contributes to the understanding of the world, which is crucial to the formation of opinions concerning pertinent issues to the citizen’s duty. For this, we studied the programming guides of some of Lisbon`s and Brasilia’s radios, in 2011 and 2012, and also interviewed their directors. In addition to that, focus groups were conducted in the context of different social organizations, in order to understand the relationship between citizens and the radio. In general, we have noticed that the radio still has a great civic potential, but currently, its programming does not contribute much to the stimulation of an effective citizenship.   KEYWORDS: Radio; Citizenship; Democracy; Public Sphere; Journalism.     RESUMEN Es importante analizar el papel de los medios de comunicación como uno de los

  17. Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells.

    Science.gov (United States)

    Liu, Quan; Liu, Juan; Roschmann, Kristina Irene Lisolette; van Egmond, Danielle; Golebski, Korneliusz; Fokkens, Wytske Johanna; Wang, Dehui; van Drunen, Cornelis Maria

    2013-04-11

    HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulation of histone acetylation on LL-37 expression in airway epithelium remains largely unknown. Therefore, we investigated the effects of two non-selective HDACi, trichostatin A (TSA) and sodium butyrate (SB), on the expression of the cathelicidin LL-37 in human airway epithelial cells. LL37 in human NCI-H292 airway epithelial cells and the primary cultures of normal nasal epithelial cells(PNEC) in response to HDAC inhibitors with or without poly (I:C) stimulation was assessed using real-time PCR and western blot. In parallel, IL-6 expression was evaluated by ELISA. Our results showed that HDAC inhibitors up-regulated LL-37 gene expression independent of poly (I:C) stimulation in PNEC as well as in NCI-H292 cells. HDAC inhibitors increased LL37 protein expression in NCI-H292 cells but not in PNEC. In addition, HDAC inhibitors significantly inhibited poly (I:C)-induced IL-6 production in both of the epithelial cells. In conclusion, HDAC inhibitors directly up-regulated LL-37 gene expression in human airway epithelial cells.

  18. Ulex europaeus Lektininin Kan Grubu Bağlama Özgüllüğü

    OpenAIRE

    ATEŞ, Ali; ÖZGÜR, Yeşim

    2002-01-01

    Bu çalışmada, Ulex europaeus bitkisinden elde edilen Ulex europaeus Aglutinin-I (UEA-I)’in insan kan grubu bağlama özgüllüğü ölçüldü. Bu deney için U tabanlı mikrotitrasyon kabı kullanıldı. 50µg/ml lektin çözeltisi, PBS (phosphate buffered saline) ile hazırlanarak başlangıç konsantrasyonu olarak alındı ve UEA-I’in seri sulandırılması ile insan kan grubu özgüllüğü belirlendi. Sonuç olarak, UEA-I’in %2’lik A grubu eritrositlerini 25µg/ml konsantrasyonda, B grubu eritrositlerini 6.25µg/ml konsan...

  19. Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo.

    Science.gov (United States)

    Durnaś, Bonita; Piktel, Ewelina; Wątek, Marzena; Wollny, Tomasz; Góźdź, Stanisław; Smok-Kalwat, Jolanta; Niemirowicz, Katarzyna; Savage, Paul B; Bucki, Robert

    2017-07-26

    Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials. We tested the in vitro activity of ceragenins CSA-13 and CSA-131 against several anaerobic bacteria including Bacteroides spp. and Clostridium difficile. We compared results to the activity of cathelicidin LL-37, metronidazole and nanosystems developed by attachment of CSA-13 and CSA-131 to magnetic nanoparticles (MNPs). The antibacterial effect was tested using killing assay and modified CLSI broth microdilution assay. Ceragenins CSA-13 and CSA-131 displayed stronger bactericidal activity than LL-37 or metronidazole against all of the tested bacterial strains. Additionally CSA-131 revealed an enhanced ability to prevent the formation of Bacteroides fragilis and Propionibacterium acnes biofilms. These data confirmed that ceragenins display antimicrobial activity against a broad range of microorganisms including anaerobic bacteria and deserve further investigations as compounds serving to develop new treatment against anaerobic and mixed infections.

  20. População nuclear e extranuclear em rádio-galáxias

    Science.gov (United States)

    Raimann, D. I.; Storchi-Bergmann, T.; Quintana, H.; Alloin, D.; Hunstead, R.; Wisotzki, L.

    2003-08-01

    A natureza do contínuo UV/ótico em rádio-galáxias é muito importante para o seu entendimento. Em baixos redshifts existem evidências de que muitas delas são dominadas no ótico por luz de estrelas velhas, características de galáxias early-type e em altos redshifts a característica dominante é um excesso de luz no UV, freqüentemente associado com estruturas que estão alinhadas aos eixos das estruturas rádio em grande escala. Inicialmente esse excesso foi interpretado como devido a episódios intensos de formação estelar nas galáxias hospedeiras. Entretanto, as descobertas dos alinhamentos entre as estruturas UV e rádio modificaram essa idéia. Foi proposto que a formação estelar é iniciada pela passagem do jato rádio através do meio interestelar das galáxias hospedeiras. A natureza do excesso UV começou a ser compreendida em um estudo detalhado do continuo ótico da 3C321, onde se concluiu que o contínuo desta galáxia tem origem multicomponente, com contribuições de populações velhas e intermediárias, de luz espalhada oriunda de um quasar obscurecido e do contínuo nebular. No presente trabalho estudamos a população nuclear e extranuclear de uma amostra de 24 rádio-galáxias, utilizando espectros óticos de fenda longa, com alta razão sinal/ruído. Através do método de síntese espectral de populações estelares, foram estimadas as contribuições de populações estelares de diferentes idades (e de um contínuo tipo lei de potência devido a um AGN, FC) para a luz integrada das galáxias, em 4020Å. As principais conclusões deste trabalho são: apenas quatro dos objetos estudados têm contribuições significativas (maiores do que 10%) das populações de 100 milhões de anos ou mais jovens (ou de FC) ao longo da região espacial estudada (6 kpc centrais); nenhuma das rádio-galáxias de tipo FRI estudadas tem contribuição significativa destas populações ao longo desta região; duas (de oito) de tipo FRII tem contribui

  1. Cathelicidin (LL-37) and its correlation with pro-oxidant, antioxidant balance and disease activity in systemic lupus erythematosus: a cross-sectional human study.

    Science.gov (United States)

    Sahebari, M; Roshandel, G; Saadati, N; Saghafi, M; Abdolahi, N; Rezaieyazdi, Z

    2017-08-01

    Background Cathelicidin (LL-37), an endogenous antimicrobial peptide, has recently been involved in the pathogenesis of autoimmune diseases. To assess whether LL-37 reflects disease activity, we measured serum levels of it in systemic lupus erythematosus (SLE) patients with active and inactive disease compared to healthy controls. LL-37 was also compared between new and old cases. Moreover, the correlation of LL-37 and pro-oxidant, antioxidant balance (PAB) was measured. Methods The study population consisted of 50 SLE patients and 28 healthy controls. Of those, 39 patients had active and 11 patients had inactive disease. Serum levels of LL-37 were measured by ELISA and PAB values by a special method. Results There was no difference in levels of LL-37 between patients and healthy controls (50.9 ± 20.8 vs. 67.7 ± 43.3 ng/ml, P = 0.31). LL-37 did not correlate with SLEDAI and its items in total patients. LL-37 had a positive correlation with SLEDAI in active patients ( P = 0.01, r = 0.4). In active patients (78% of patients), multivariate regression analysis showed significant negative correlation between LL-37 and C3 ( P = 0.01, standardized beta -0.50). No difference was found in levels of PAB between patients and controls (90.4 ± 34.1 vs. 86.9 ± 25.6 HK, P = 0.4).There was no difference in the levels of PAB between patients with active and inactive disease (93.2 ± 34.1 vs. 80.2 ± 33.7 HK, P = 0.27). No correlation was found between levels of PAB and SLEDAI items and total score. However, a positive correlation between the levels of LL-37 and PAB in SLE patients was found ( r = 0.3, P lupus compared with healthy individuals. LL-37 serum values rose in parallel with SLEDAI in active disease. Positive correlation between serum PAB and LL-37 could be a great achievement of this study that may suggest the role of antioxidants in controlling NETosis.

  2. Measurement of the spin-spin correlation parameter C/sub LL/(THETA) in proton-proton scattering

    International Nuclear Information System (INIS)

    Stuart, S.J.

    1982-08-01

    The experimental procedures and methods of data analysis used to measure the spin-spin correlation parameter C/sub LL/(THETA) in proton-proton scattering at thirteen different energies in the range 300 to 800 MeV are presented. The results compare favorably with previous data. Good agreement is found with phase shift predictions at energies below 500 MeV

  3. The (re)-introduction of semiotics into medical education: on the works of Thure von Uexküll.

    Science.gov (United States)

    Tredinnick-Rowe, John

    2017-03-01

    Thure von Uexküll's reputation as a pioneer in biosemiotics and also in psychosomatic medicine is well documented. It is easy to see these disciplines reflected in his notable publications, both in English and in German. However, if one spares the time to filter through all of his articles, monographs, conference papers and editorials in English and in German, a notable gap arises in his English language publications: that of clinical education. This gap in the English language literature may seem unimportant in and of itself, but it speaks volumes when we consider the total absence of medical semiotics in the curriculum of medical schools in the English speaking world. This runs in stark contrast to the strong traditions of psychosomatic medicine in Germany, which Thure von Uexküll largely helped to instil. Do the works of Thure von Uexküll offer a possible step towards a resurrection of medical semiotics in clinical education? This chapter attempts to explore the lesser known German literature on clinical education that Thure von Uexküll produced, and explore the role semiotics can play in Medical Education in the English speaking world. While also seeking to contrast this literature with other existing approaches in British and American medical schools who have attempted to reintroduce medical humanities and reflexive thinking into clinical education. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  4. Sikap Masyarakat Surabaya terhadap Iklan AirAsia “We'll Take You There” di Televisi

    OpenAIRE

    Mahesthi, Athanasia Placidia

    2017-01-01

    Selama tahun 2015, AirAsia mengeluarkan sebanyak 8 iklan komersial di televisi, 2 diantaranya merupakan iklan yang memiliki tema berbeda daripada iklan televisi Low Cost Carier pada umumnya. Salah satu iklan televisi AirAsia adalah iklan “We'll Take You There” yang dirilis pada tanggal 1 November 2015 di berbagai stasiun televisi. Iklan ini terdiri dari beberapa penggalan cerita yang diperagakan oleh talent dari berbagai kalangan usia. Iklan ini memiliki pesan iklan bahwa AirAsia akan mengant...

  5. Prokaryotic Selectivity, Anti-endotoxic Activity and Protease Stability of Diastereomeric and Enantiomeric Analogs of Human Antimicrobial Peptide LL-37

    International Nuclear Information System (INIS)

    Nan, Yong Hai; Lee, Bongju; Shin, Song Yub

    2012-01-01

    LL-37 is the only antimicrobial peptide (AMP) of the human cathelicidin family. In addition to potent antimicrobial activity, LL-37 is known to have the potential to inhibit lipolysaccharide (LPS)-induced endotoxic effects. To provide the stability to proteolytic digestion and increase prokaryotic selectivity and/or anti-endotoxic activity of two Lys/Trp-substituted 19-meric anti-microbial peptides (a4-W1 and a4-W2) designed from IG-19 (residues 13-31 of LL-37), we synthesized the diastereomeric peptides (a4-W1-D and a4-W2-D) with D-amino acid substitution at positions 3, 7, 10, 13 and 17 of a4-W1 and a4-W2, respectively and the enantiomeric peptides (a4-W1-E and a4-W2-E) composed D-amino acids. The diastereomeric peptides exhibited the best prokaryotic selectivity and effective protease stability, but no or less anti-endotoxic activity. In contrast, the enantiomeric peptides had not only prokaryotic selectivity and anti-endotoxic activity but also protease stability. Our results suggest that the hydrophobicity and α-helicity of the peptide is important for anti-endotoxic activity. In particular, the enantiomeric peptides showed potent anti-endotoxic and LPS-neutralizing activities comparable to that of LL-37. Taken together, both a4-W1-E and a4-W2-E holds promise as a template for the development of peptide antibiotics for the treatment of endotoxic shock and sepsis

  6. Prokaryotic Selectivity, Anti-endotoxic Activity and Protease Stability of Diastereomeric and Enantiomeric Analogs of Human Antimicrobial Peptide LL-37

    Energy Technology Data Exchange (ETDEWEB)

    Nan, Yong Hai; Lee, Bongju; Shin, Song Yub [Chosun Univ., Gwangju (Korea, Republic of)

    2012-09-15

    LL-37 is the only antimicrobial peptide (AMP) of the human cathelicidin family. In addition to potent antimicrobial activity, LL-37 is known to have the potential to inhibit lipolysaccharide (LPS)-induced endotoxic effects. To provide the stability to proteolytic digestion and increase prokaryotic selectivity and/or anti-endotoxic activity of two Lys/Trp-substituted 19-meric anti-microbial peptides (a4-W1 and a4-W2) designed from IG-19 (residues 13-31 of LL-37), we synthesized the diastereomeric peptides (a4-W1-D and a4-W2-D) with D-amino acid substitution at positions 3, 7, 10, 13 and 17 of a4-W1 and a4-W2, respectively and the enantiomeric peptides (a4-W1-E and a4-W2-E) composed D-amino acids. The diastereomeric peptides exhibited the best prokaryotic selectivity and effective protease stability, but no or less anti-endotoxic activity. In contrast, the enantiomeric peptides had not only prokaryotic selectivity and anti-endotoxic activity but also protease stability. Our results suggest that the hydrophobicity and α-helicity of the peptide is important for anti-endotoxic activity. In particular, the enantiomeric peptides showed potent anti-endotoxic and LPS-neutralizing activities comparable to that of LL-37. Taken together, both a4-W1-E and a4-W2-E holds promise as a template for the development of peptide antibiotics for the treatment of endotoxic shock and sepsis.

  7. The Effect of Calcipotriol on the Expression of Human β Defensin-2 and LL-37 in Cultured Human Keratinocytes

    Directory of Open Access Journals (Sweden)

    Beom Joon Kim

    2009-01-01

    Full Text Available Background. Vitamin D has been reported to regulate innate immunity by controlling the expression of antimicrobial peptides (AMPs. Objective. We investigated the effect of calcipotriol on the expression of AMPs in human cultured keratinocytes. Methods. Keratinocytes were treated with lipopolysaccharide (LPS, TNF-α, Calcipotriol and irradiated with UVB, cultured, and harvested. To assess the expression of human beta defensin-2 and LL-37 in the control group, not exposed to any stimulants, the experimental group was treated with LPS, TNF-α, or UVB, and another group was treated again with calcipotriol; reverse transcriptase-polymerase chain reaction, Western blotting, and immunohistochemical staining were performed. Results. In the experimental group treated with LPS, UVB irradiation, and TNF-α, the expression of β-defensin and LL-37 was increased more than in the control group and then decreased in the experimental group treated with calcipotriol. Conclusions. Calcipotriol suppressed HBD-2 and LL-37, which were stimulated by UVB, LPS, and TNF-α.

  8. An ll-Diaminopimelate Aminotransferase Defines a Novel Variant of the Lysine Biosynthesis Pathway in Plants1[W

    Science.gov (United States)

    Hudson, André O.; Singh, Bijay K.; Leustek, Thomas; Gilvarg, Charles

    2006-01-01

    Although lysine (Lys) biosynthesis in plants is known to occur by way of a pathway that utilizes diaminopimelic acid (DAP) as a central intermediate, the available evidence suggests that none of the known DAP-pathway variants found in nature occur in plants. A new Lys biosynthesis pathway has been identified in Arabidopsis (Arabidopsis thaliana) that utilizes a novel transaminase that specifically catalyzes the interconversion of tetrahydrodipicolinate and ll-diaminopimelate, a reaction requiring three enzymes in the DAP-pathway variant found in Escherichia coli. The ll-DAP aminotransferase encoded by locus At4g33680 was able to complement the dapD and dapE mutants of E. coli. This result, in conjunction with the kinetic properties and substrate specificity of the enzyme, indicated that ll-DAP aminotransferase functions in the Lys biosynthetic direction under in vivo conditions. Orthologs of At4g33680 were identified in all the cyanobacterial species whose genomes have been sequenced. The Synechocystis sp. ortholog encoded by locus sll0480 showed the same functional properties as At4g33680. These results demonstrate that the Lys biosynthesis pathway in plants and cyanobacteria is distinct from the pathways that have so far been defined in microorganisms. PMID:16361515

  9. Portrait of Gunnar Källén a physics shooting star and poet of early quantum field theory

    CERN Document Server

    2014-01-01

    Wolfgang Pauli referred to him as 'my discovery,' Robert Oppenheimer described him as 'one of the most gifted theorists' and Niels Bohr found him enormously stimulating. Who was the man in question, Gunnar Källén (1926-1968)? His appearance in the physics sky was like a shooting star. His contributions to the scientific debate caused excitement among young and old. Similar to his friend and mentor, Wolfgang Pauli, he demanded honesty and rigor in physics - a distinct dividing line between fact and speculation. In his obituary, Arthur S. Wightman would write: 'Gunnar Källén was a proud continuer of the tradition in quantum field theory established by Wolfgang Pauli. His papers on quantum electrodynamics in the period 1950-1954 carried the non-perturbative approach to quantum electrodynamics forward to a point beyond which very little essential progress has been made up to the present day. At the time I was trying to puzzle out the grammar of the language of quantum field theory, and here was Källén al...

  10. Pharmacobotanic characterization of young stems and stem barks of Rauvolfia sellowii Müll. Arg., Apocynaceae

    Directory of Open Access Journals (Sweden)

    Leopoldo Clemente Baratto

    2010-09-01

    Full Text Available Rauvolfia sellowii Müll. Arg. (Apocynaceae, a Brazilian native tree rich in indole alkaloids, is known as "pau-pra-tudo" and popularly used as hypocholesterolemic, hypoglycemic and antihypertensive. The aim of this work was to study the anatomy of the young stems and stem barks of this medicinal plant, in order to contribute to the identification of the species as a drug. The plant material was fixed and prepared according to standard microtechniques. The young stems have remaining epidermis, but a suberified peridermis is evident. The phellogen is located in the cortical region, forming suber externally. Underneath the phellogen, lies the phelloderm and collenchymatic region. In the cortex, there are numerous laticifers and some fibers. There is an incomplete sclerenchymatic sheath, consisting of several groups of fibers and stone cells. The stem has internal phloem ordered as isolated groups side by side. Numerous laticifers, calcium oxalate crystals, idioblasts and amyloplasts are found in the cortex, phloem, xylem and pith. The stem bark has many layers of suber and cortical parenchyma, a sheath composed of fibers and stone cells totally lignified, and external phloem. These anatomical characteristic, taken together, can be used as quality control parameters for this species.Rauvolfia sellowii Müll. Arg. (Apocynaceae, uma árvore nativa brasileira rica em alcaloides indólicos, é conhecida como "pau-pra-tudo" e utilizada popularmente como hipocolesterolêmica, hipoglicêmica e anti-hipertensiva. O presente trabalho teve como objetivo caracterizar anatomicamente o caule jovem e a casca caulinar dessa planta medicinal, a fim de contribuir para a identificação e autenticidade da droga. O material vegetal foi fixado e submetido às microtécnicas usuais. O caule jovem possui epiderme remanescente, porém uma periderme suberificada é observada. O felogênio instala-se na região cortical, formando súber externamente. Subjacentes ao felog

  11. The Storage Stability of Anthocyanins in Mao (Antidesma thwaitesianum Müll. Arg. Juice and Concentrate

    Directory of Open Access Journals (Sweden)

    Prommakool Arunya

    2016-01-01

    Full Text Available Mao or Makmao (Antidesma thwaitesianum Müll. Arg. is a wild plant found in the northeast of Thailand. Mao is one of fruits which are source of anthocyanins. Mao fruits are used for juice and concentrate which are consumed for healthy drinks. Determination of the kinetic parameters is essential to predict the quality changes and stability of anthocyanins in Mao juice and concentrate that occur during storage. The purpose of this research was to study the degradation of anthocyanins in Mao juice and concentrate during storage at 5, 30 and 37°C for 15 days. The storage stability of Mao anthocyanins was studied in 15°Brix juice and 45°Brix concentrate. The degradation kinetic (k, half-life (t1/2, activation energy (Ea and Q10 values for Mao anthocyanins degradation were determined. The results indicated that analysis of kinetic data for the degradation of anthocyanins followed a first-order reaction. An increase storage temperature from 5 to 30 and 37°C increased k value of anthocyanins in Mao juice and concentrate. Increasing storage temperature decreased t1/2 value of anthocyanins in both concentrations. At 5, 30 and 37°C, the t1/2 of anthocyanins decreased from 35 to 13 and 5 days for Mao juice and 32 to 25 and 21 days for Mao concentrate. The Ea value of the anthocyanins degradation in Mao juice and concentrate were 38.03 and 8.42 kJ/mol, respectively. Q10 values of both Mao juice and concentrate at 30-37°C were higher than those were storaged at 5-30°C. Thus higher stability of anthocyanins was achieved by using concentration and storage at lower temperature.

  12. Algunas reflexiones de conjunto sobre el misterio del Dios uno y trino

    Directory of Open Access Journals (Sweden)

    Sergio Zañartu U.

    2001-01-01

    Full Text Available El autor, en un estilo conclusivo, destaca la inmanencia y trascendencia como típicas de toda experiencia de Dios. En la suma inmanencia de la Encarnación, Dios se muestra el sumo trascedente y revela las tres personas, sin las cuales no se comprendería la posibilidad de la Encarnación redentora. Si Cristo es Dios con nosotros y el Espíritu su don en nuestros corazones, es en el Padre donde sobre todo percibimos la trascendencia. La revelación del interior de Dios se inserta, por así decirlo, en ese Dios que el hombre oscuramente busca en la teología negativa. Del esplendor de ese Dios nos habla la revelación. Pero no hay que trivializarlo. El ateísmo es una mala interpretación de la experiencia humana. El autor muestra la búsqueda de una expresión dogmática y de una comprensión, y las dificultades que esto conlleva. Aunque integra varias visiones, insiste en la economía. De esta forma recalca la monarquía del PadreThe author, in a conclusive style, highlights the immanence and transcendence as typical of any experience of God. In the supreme immanence act of the Incarnation, God shows himself as the supreme transcendent and discloses the three persons, without which the possibility of the redeeming Incarnation would be incomprehensible. If Christ is God with us, and the Holy Spirit is his gift in our hearts, then, it is in the Father where we perceive, above all, the transcendence. The revelation of God's interior is inserted in that God which man obscurely seeks in negative theology. The revelation talks to us about the splendour of this God. But this issue should not be trivialised. Atheism is a misinterpretation of the human experience. The author shows the search of a dogmatic expression, of an understanding and of the complexities this brings along. Through an integration of several visions, the author insists on the economy, stressing the Father's monarchy.

  13. Development of an instrument to measure the quality of documented nursing diagnoses, interventions and outcomes: the Q-DIO.

    Science.gov (United States)

    Müller-Staub, Maria; Lunney, Margaret; Odenbreit, Matthias; Needham, Ian; Lavin, Mary Ann; van Achterberg, Theo

    2009-04-01

    This paper aims to report the development stages of an audit instrument to assess standardised nursing language. Because research-based instruments were not available, the instrument Quality of documentation of nursing Diagnoses, Interventions and Outcomes (Q-DIO) was developed. Standardised nursing language such as nursing diagnoses, interventions and outcomes are being implemented worldwide and will be crucial for the electronic health record. The literature showed a lack of audit instruments to assess the quality of standardised nursing language in nursing documentation. A qualitative design was used for instrument development. Criteria were first derived from a theoretical framework and literature reviews. Second, the criteria were operationalized into items and eight experts assessed face and content validity of the Q-DIO. Criteria were developed and operationalized into 29 items. For each item, a three or five point scale was applied. The experts supported content validity and showed 88.25% agreement for the scores assigned to the 29 items of the Q-DIO. The Q-DIO provides a literature-based audit instrument for nursing documentation. The strength of Q-DIO is its ability to measure the quality of nursing diagnoses and related interventions and nursing-sensitive patient outcomes. Further testing of Q-DIO is recommended. Based on the results of this study, the Q-DIO provides an audit instrument to be used in clinical practice. Its criteria can set the stage for the electronic nursing documentation in electronic health records.

  14. Determinantes espaciais e socioeconômicos do suicídio no Brasil: uma abordagem regional

    Directory of Open Access Journals (Sweden)

    Ludmilla R. C. Gonçalves

    2012-01-01

    Full Text Available A Organização Mundial da Saúde avalia o suicídio como um problema de saúde pública, estando entre as dez causas mais frequentes de morte, além de ser a segunda ou terceira causa de morte entre 15 e 34 anos de idade. Estimativas mostram que para cada suicídio, existem pelo menos dez tentativas suficientemente sérias que exigem atenção médica e para cada tentativa de suicídio registrada, existem quatro não conhecidas. O objetivo desse artigo é avaliar os determinantes socioeconômicos das taxas de suicídio por microrregiões brasileiras, levando em consideração aspectos espaciais do problema. A hipótese desse artigo é que existe um “efeito contágio” espacial para o suicídio, ou seja, as taxas de suicídio dos vizinhos de uma microrregião são importantes determinantes do comportamento dessa variável em outra microrregião. Para tal, são usadas técnicas de econometria espacial que permitem avaliar se existe dependência espacial entre as taxas de suicídio das microrregiões.

  15. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model.

    Science.gov (United States)

    Collins, K H; Paul, H A; Reimer, R A; Seerattan, R A; Hart, D A; Herzog, W

    2015-11-01

    Osteoarthritis (OA) may result from intrinsic inflammation related to metabolic disturbance. Obesity-associated inflammation is triggered by lipopolysaccharide (LPS) derived from the gut microbiota. However, the relationship between gut microbiota, LPS, inflammation, and OA remain unclear. To evaluate the associations between gut microbiota, systemic LPS levels, serum and local inflammatory profiles, and joint damage in a high fat/high sucrose diet induced obese rat model. 32 rats were randomized to a high fat/high sucrose diet (diet-induced obese (DIO), 40% fat, 45% sucrose, n = 21) or chow diet group (12% fat, 3.7% sucrose n = 11) for 28 weeks. After a 12-week obesity induction period, DIO animals were stratified into Obesity Prone (DIO-P, top 33% by change in body mass, n = 7), and Obesity Resistant groups (DIO-R, bottom 33%, n = 7). At sacrifice, joints were scored using a Modified Mankin Criteria. Blood and synovial fluid analytes, serum LPS, and fecal gut microbiota were analyzed. DIO animals had greater Modified Mankin scores than chow animals (P = 0.002). There was a significant relationship (r = 0.604, p = 0.001) between body fat, but not body mass, and Modified Mankin score. Eighteen synovial fluid and four serum analytes were increased in DIO animals. DIO serum LPS levels were increased compared to chow (P = 0.031). Together, Lactobacillus species (spp.) and Methanobrevibacter spp. abundance had a strong predictive relationship with Modified Mankin Score (r(2) = 0.5, P gut microbiota and adiposity-derived inflammation and metabolic OA warrants further investigation. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  16. [Effects of antimicrobial peptide LL-37 expressed and purified from prokaryotes in the murine model of vaginal candidiasis].

    Science.gov (United States)

    Wang, F; Huo, Y; Yin, L R; Sun, B; Zhang, P P

    2016-07-25

    To study the effects of antimicrobial peptide LL-37 expressed and purified from prokaryotes on candida albicans growth. (1)Thirty female Kunming mice were treated with estrogen and white candida yeast suspension were poured into vagina to establish a vulvovaginal candidiasis(VVC)murine model. After successful establishing the VVC mouse model, mice were randomly sorted into test group(n=15)and control group(n=15). Suspension(30 μl, 100 μg/ml)of recombinant peptide LL-37 expressed and purified in Prokaryotes was given by intravaginal administration to the test group for 5 days, while the same amount of phosphate buffered saline(PBS)was given to the control group.(2)Tweenty-four hours after treatment, the fungal burden and colony-forming unit(CFU)of vaginal fluids were evaluated. All mice were subsequently sacrificed and vaginal tissues were harvested for tissue homogenate preparation. ELISA was used to determine the levels of nterleukin-10(IL-10)and interferon-γ(IFN-γ)in the isolated vaginal tissues. (1)VVC mouse model was established successfully in this study. Vaginal mucosa congestion, edema, vaginal plica disappearing were obviously observed in the control group. After treatment with recombinant protein LL-37 vaginal mucosa has no obvious change in the test group.(2)Fungal burden and CFU of vaginal fluids were significantly lower in the test group [(4.8±1.0)×10(4) CFU/ml]than that in the control group [(8.5±2.1)×10(4) CFU/ml, P=0.017]. IFN-γ level of the test group was increased [(257±11)vs(197±4)pg/ml, P=0.000], while the level of IL-10 was reduced [(287 ± 15)vs(379 ± 17)pg/ml P=0.000] resulting in a the ratio of IFN-γ/IL-10 was in significantly higher in test group(0.892±0.008 vs 0.496±0.013, P=0.000). Recombinant protein LL-37 expressed and purified from prokaryotes inhibits the growth candida albicans and improves vaginal immunity by adjusting IFN-γ and IL-10 secretion in the VVC mouse model, highlighting the therapeutic potential of LL-37

  17. Autores de homicídios passionais: narrativas do crime, histórias de vida e dos relacionamentos

    OpenAIRE

    Barbosa, Bibiana Calatayud

    2015-01-01

    A violência de gênero constitui uma problemática relevante em nossa sociedade. Nos casos mais graves, pode culminar em episódios de extrema violência, os homicídios passionais. Objetivos: Este estudo investigou a história de vida e dos relacionamentos amorosos de autores de homicídios passionais, identificando suas vivências e narrativas sobre os eventos desta trajetória, até o cometimento do crime. Método: Foi utilizado o procedimento de estudo de casos múltiplos. Participaram três homens co...

  18. Loucas, certinhos ou incompetentes : uma etnografia do assédio moral entre professoras e professores do distrito federal

    OpenAIRE

    Tiba, Thaisa Marilia Coelho

    2014-01-01

    A partir de uma pesquisa de campo realizada com professores e professoras do ensino fundamental e médio, diretores e diretoras sindicais, advogados, psicólogos e psiquiatras, entre outros profissionais, apresenta-se uma etnografia das ações de assédio moral nas escolas públicas do Distrito Federal brasileiro, bem como das práticas de reestabelecimento dos professores e das professoras sujeitos a essas ações. Se para Hirigoyen (2009) o assédio moral é caracterizado por toda e qualquer conduta ...

  19. É possível discutir o assédio moral na enfermagem?

    OpenAIRE

    Hagopian, Ellen M.; Freitas, Genival Fernandes de; Costa, Kleber S.

    2016-01-01

    O assédio moral representa uma conduta antiética que rompe com o equilíbrio no ambiente de trabalho e se mostra contrário aos bons costumes e à boa-fé que deve nortear as relações sociais e laborais (Alkimin, 2005). Objetivo: Identificar e analisar a produção científica sobre o fenômeno do assédio moral na enfermagem. Método: Revisão sistemática de literatura com abordagem qualitativa. Critérios de inclusão: todas as categorias de artigos com textos completos; publicados nos idiomas português...

  20. Educação financeira para o ensino médio

    OpenAIRE

    Venturini, Rodrigo Cesar Pastrolin

    2016-01-01

    Este trabalho tem como objetivo destacar a importância do ensino e da aprendizagem da Matemática Financeira no Ensino Médio. Consideramos que este é um assunto de grande relevância no cotidiano dos jovens que provavelmente farão uso do sistema bancário e do comércio. Colocamos em discussão a situação atual do ensino da Matemática Financeira e apresentamos elementos para argumentação da sua importância no momento em que se elencam os conteúdos do Ensino Médio. Além disso, mos...

  1. El Dios razonable de la gran catequesis de Gregorio de Nisa

    Directory of Open Access Journals (Sweden)

    Sergio Zañartu

    2004-01-01

    Full Text Available El articulista, después de introducirnos en este tipo de escrito y sus destinatarios, nos presenta todo el material sobre Dios que en él aparece, remitiéndonos a innumerables citas. Gregorio usa relativamente poco el vocabulario trinitario, centrándose en Dios. Presenta los atributos de este Dios, que a menudo es llamado fusiV y dunamiV, no desarrollando demasiado una teología negativa. A Dios se lo conoce por sus obras; la divinidad de Cristo por los milagros. Dios crea y salva por bondad. El mundo es bueno y el hombre fue creado en todo bien para que participara en los bienes divinos. El verdadero mal es ausencia de virtud y surge en la libertad. El hombre pasa a ser mortal para que el cuerpo sea purificado del mal por la muerte. No es indigno de Dios el nacimiento y la muerte. Cristo, al tocar la muerte la hace desaparecer y vuelve a unir para siempre el cuerpo y el alma. Dios nos ha liberado por bondad y con sabiduría, poder y justicia (respecto al adversario. La redención se nos aplica por la imitación del bautismo y la comida eucarística que nos transforma hacia la incorruptibilidad. El alma no purificada por la virtud, será purificada por el fuego del juicio para retornar a la gracia del principio, apocatástasis. Su cristología y redención es sobre todo descendente. En todo se muestra un Dios razonableAfter introducing Gregory of Nyssa's writing style and his addressees, the author presents all the references to God contained in his Work, by means of innumerable quotations. Gregory uses the Trinitarian vocabulary scarcely, focusing on God itself. He presents the attributes of this God, who is usually called fusiV and dunamiV, but he does not develop much of a negative theology. God is known by his works; Christ's divinity by his miracles. God creates and saves out of goodness. The world is good and men were created in state of goodness to participate of the divine goods. The only true evil is the absence of virtue, which

  2. Exame Nacional do Ensino Médio e acesso de estudantes surdos ao Ensino Superior Brasileiro

    Directory of Open Access Journals (Sweden)

    Diléia Ap. Martins

    2015-12-01

    Full Text Available Resumo Este trabalho apresenta as primeiras aproximações relativas à pesquisa "Acessibilidade e Exame Nacional do Ensino Médio: desafios para a escolarização de estudantes surdos", inserida no programa Observatório em Educação (Obeduc, Projeto Acessibilidade no Ensino Superior. Investiga dados oficiais publicados pelo Instituto Nacional de Estudos e Pesquisas (Inep, referentes ao aumento progressivo do número de matrículas de estudantes surdos em Instituições de Ensino Superior (IES. Analisa questões relativas à nota obtida por esses estudantes, ao se submeterem ao Exame Nacional do Ensino Médio (Enem, e o uso dessa nota para ingressarem em universidades brasileiras. Os dados analisados, no presente artigo, indicam discrepância de desempenho de estudantes sem deficiência, quando comparados aos estudantes surdos.

  3. First results for the two-spin parameter A sub LL in. pi. sup 0 production by 200 GeV polarized protons and antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D L; Corcoran, M D; Cranshaw, J; Nessi-Tedaldi, F; Nessi, M; Nguyen, C; Roberts, J B; Skeens, J; White, J L [Rice Univ., Houston, TX (USA). Bonner Nuclear Labs.; Akchurin, N; Onel, Y [Iowa Univ., Iowa City (USA). Dept. of Physics and Astronomy; Belikov, N I; Derevschikov, A A; Grachov, O A; Matulenko, Yu A; Meschanin, A P; Nurushev, S B; Patalakha, D I; Rykov, V L; Solovyanov, V L; Vasiliev, A N [Institut Fiziki Vysokikh Ehnergij, Serpukhov (USSR); Bystricky, J; Chaumette, P; Deregel, J; Durand, G; Fabre, J; Lehar, F; Lesquen, A de [CEA Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France); Cossairt, J D; Read, A L [Fermi National Accelerator Lab., Batavia, IL (USA); En' yo, H; Funahashi, H; Goto, Y; Imai, K; Itow, Y; Makino, S; Masaike, A; Miyake, K; Nagamine, T; Saito, N; Yamashita, S [Kyoto Univ. (Japan). Dept. of Physics; Fukuda, K [Meiji Coll. of Oriental Medicine, Kyoto (Japan); Grosnick, D P; Hill, D A; FNAL E581/704 Collaboration

    1991-05-23

    The two-spin parameter A{sub LL} in inclusive {pi}{sup 0} production by longitudinally-polarized protons and antiprotons on a longitudinally-polarized proton target has been measured at the 200 GeV Fermilab spin physics facility, for {pi}{sup 0}'s at x{sub F} = 0 with 1 {le} p{sub t} {le} 3 GeV/c. The results exclude, at the 95% confidence level, values of A{sub LL} (pp) > 0.1 and < -0.1, for {pi}{sup 0}'s produced by protons, and values of A{sub LL} (anti pp) > 0.1 and < -0.2 for incident antiprotons. The relevance of A{sub LL}(pp) for the gluon spin density is discussed. The data are in good agreement with 'conventional' small or zero, gluon polarization. (orig.).

  4. Review and analysis of mammographies of Servicio de Radiologia Hospital San Juan de Dios

    International Nuclear Information System (INIS)

    Araya Cerdas, Adrian; Mirambell Sanchez, Melania; Monge Vega, Mandred; Mora Vargas, Karla; Vega Aguilar, Laura

    2013-01-01

    The concept of mammography is defined. The mammography has been estimated as the best tool currently available for the detection of breast cancer in its early stages, in addition, have been detected clinically occult lesions. Mammographies of the Servicio de Radiologia Hospital San Juan de Dios were analyzed for a total of 1250. The findings were related as static between BIRADS categorization and inherited-family factors, geographical and personal pathological of patients treated in the period September 2012 to January 2013 [es

  5. La macchina che cerca Dio. Nasce LHC forse scoprira' Higgs elusiva particella della creazione

    CERN Multimedia

    Bianucci, P

    2003-01-01

    "LEON Lederman, premio Nobel per la fisica, l'ha misticamente definita la particella di Dio perche' sarebbe il pilastro sul quale si appoggia tutta la materia dell'universo che conosciamo. Piu' tecnicamente, e' la "particella di Higgs", un bosone previsto dal Modello Standard del microcosmo la cui esistenza sarebbe necessaria per giustificare, anche quantitativamente, la massa di tutte le particelle" (1/2 page).

  6. Considerações sobre trabalho e suicídio: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Marcelo Augusto Finazzi-Santos

    Full Text Available As empresas vêm presenciando o suicídio de seus empregados, atribuído, de acordo com Dejours e Bègue (2010, às consequências negativas das novas organizações do trabalho. Com base no estudo de óbito de trabalhador bancário, o foco deste artigo é avaliar se o trabalho poderia ser um dos fatores relacionado à decisão de cometer-se o suicídio. Avaliou-se o significado qualitativo da morte sob o ponto de vista do irmão do suicida (ambos colegas de trabalho durante mais de 20 anos, entrevistado em 2009. Visto que esse tipo de análise produz volume significativo de dados sobre o fenômeno pesquisado, estes foram processados e analisados por meio de análise categorial. O bancário trabalhava na empresa havia três décadas e morreu em meados de 2000, faltando um ano para aposentadoria, após a esposa requerer o divórcio. O trabalho foi o contexto para compreender o processo que o conduziu à ruína familiar, à exasperação psíquica e, por fim, à morte. O caso não envolveu assédio moral, já que se tratava de empregado muito bem conceituado, mas de patologia associada à servidão voluntária, patologia essa cada vez mais estimulada como símbolo de sucesso. No ambiente de trabalho, problemas conjugais foram os fatores atribuídos como causa maior do suicídio, mais conveniente como forma de eximir responsabilidades perante o infortúnio, transferindo somente ao sujeito a culpa por conflitos pessoais ou desordens psíquicas.

  7. Energy dependence of Lα-to-Ll x-ray intensity ratios for Yb and Pb produced by heavy-ion bombardment

    International Nuclear Information System (INIS)

    Gray, T.J.

    1980-01-01

    Measurements of the incident-ion energy dependence of Lα-to-Ll x-ray intensity ratios are reported for protons incident at 0.40 to 2.20 MeV/amu on thin targets of Pb and for 4 He and C ions incident upon Yb. The data are compared to calculations of the Lα-to-Ll ratio which include the effects of alignment of the 2p/sub 3/2/ state of the target

  8. LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity.

    Science.gov (United States)

    Rajasekaran, Ganesan; Kim, Eun Young; Shin, Song Yub

    2017-05-01

    Although the human-derived antimicrobial peptide (AMP) LL-37 has potent antimicrobial and anti-inflammatory activities, its therapeutic application is limited by its low cell selectivity and high production cost due to its large size. To overcome these problems, we tried to develop novel LL-37-derived short α-helical AMPs with improved cell selectivity and without a significant loss of anti-inflammatory activity relative to that of parental LL-37. Using amino acid substitution, we designed and synthesized a series of FK13 analogs based on the sequence of the 13-meric short FK13 peptide (residues 17-29 of LL-37) that has been identified as the region responsible for the antimicrobial activity of LL-37. Among the designed FK13 analogs, FK-13-a1 and FK-13-a7 showed high cell selectivity and retained the anti-inflammatory activity. The therapeutic index (a measure of cell selectivity) of FK-13-a1 and FK-13-a7 was 6.3- and 2.3-fold that of parental LL-37, respectively. Furthermore, FK-13-a1 and FK-13-a7 displayed more potent antimicrobial activity against antibiotic-resistant bacteria including MRSA, MDRPA, and VREF, than did LL-37. In addition, FK-13-a1 and FK-13-a7 exhibited greater synergistic effects with chloramphenicol against MRSA and MDRPA and were more effective anti-biofilm agents against MDRPA than LL-37 was. Moreover, FK-13-a1 and FK-13-a7 maintained their activities in the presence of physiological salts and human serum. SYTOX green uptake, membrane depolarization and killing kinetics revealed that FK13-a1 and FK13-a7 kills microbial cells by permeabilizing the cell membrane and damaging membrane integrity. Taken together, our results suggest that FK13-a1 and FK13-a7 can be developed as novel antimicrobial/anti-inflammatory agents. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Necromass in forests of Madre de Dios, Peru: a comparison between terra firme and lowland forests

    Directory of Open Access Journals (Sweden)

    Alejandro Araujo-Murakami

    2011-06-01

    Full Text Available Stocks of dead wood or necromass represent an important portion of biomass and nutrients in tropical forests. The objectives of this study were: 1 to evaluate and compare the necromass of “terra firme” and lowlands forests, (2 to study the relationship between necromass, above-ground biomass and wood density, and (3 to estimate the necromass of the department of Madre de Dios, Peru. Stocks of necromass and above-ground biomass were estimated at three different locations using permanent plots and line intercept transects. The average volume of necromass for the three sites was 72.9 m3 ha-1 with an average weight varying between 24.8 and 30.7 Mg ha-1, depending on the estimations of dead wood density used for the calculations. Terra firme forests had significantly higher stocks of necromass than lowland forests. The amount of necromass was 11% of the total above-ground biomass in Madre de Dios forests. The total stock of carbon stored in dead wood for the entire department of Madre de Dios was estimated to be approximately 100 mega tonnes of carbon. This is ten times more than the annual fossil fuel emissions of Peru between 2000 and 2008. The substantial stocks of necromass emphasize the importance of these types of field studies, considering that this component of tropical forest carbon cannot be detected using other methods such as satellite remote sensing.

  10. The extracellular phage-host interactions involved in the bacteriophage LL-H infection of Lactobacillus delbrueckii ssp. lactis ATCC 15808.

    Science.gov (United States)

    Munsch-Alatossava, Patricia; Alatossava, Tapani

    2013-12-24

    The complete genome sequence of Lactobacillus bacteriophage LL-H was determined in 1996. Accordingly, LL-H has been used as a model phage for the infection of dairy Lactobacillus, specifically for thermophilic Lactobacillus delbrueckii ssp. lactis host strains, such as ATCC 15808. One of the major goals of phage LL-H research consisted of the characterization of the first phage-host interactions at the level of phage adsorption and phage DNA injection steps to determine effective and practical methods to minimize the risks associated with the appearance and attack of phages in the manufacture of yogurt, and Swiss or Italian hard type cheeses, which typically use thermophilic lactic acid bacteria starter cultures containing L. delbrueckii strains among others. This mini review article summarizes the present data concerning (i) the special features, particle structure, and components of phage LL-H and (ii) the structure and properties of lipoteichoic acids (LTAs), which are the phage LL-H receptor components of L. delbrueckii ssp. lactis host strains. Moreover, a model of the first, extracellular, phage-host interactions for the infection of L. delbrueckii ssp. lactis ATCC 15808 by phage LL-H is presented and further discussed.

  11. The extracellular phage-host interactions involved in the bacteriophage LL-H infection of Lactobacillus delbrueckii ssp. lactis ATCC 15808

    Directory of Open Access Journals (Sweden)

    Patricia eMunsch-Alatossava

    2013-12-01

    Full Text Available The complete genome sequence of Lactobacillus bacteriophage LL-H was determined in 1996. Accordingly, LL-H has been used as a model phage for the infection of dairy Lactobacillus, specifically for thermophilic Lb. delbrueckii ssp. lactis host strains, such as ATCC 15808. One of the major goals of phage LL-H research consisted of the characterization of the the first phage-host interactions at the level of phage adsorption and phage DNA injection steps to determine effective and practical methods to minimise the risks associated with the appearance and attack of phages in the manufacture of yoghurt, and Swiss or Italian type hard cheeses, which typically use thermophilic LAB starter cultures containing Lb. delbrueckii strains among others. This mini review article summarises the present data concerning (i the special features, particle structure and components of phage LL-H and (ii the structure and properties of lipoteichoic acids (LTAs, which are the phage LL-H receptor components of Lb. delbrueckii ssp. lactis host strains. Moreover, a model of the first, extracellular, phage-host interactions for the infection of Lb. delbrueckii ssp. lactis ATCC 15808 by phage LL-H is presented and further discussed.

  12. Architecture Design Issues of a Reversible Deep Geological Repository for HL and IL/LL Waste

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, C.; Londe, L.; Poisson, J.B. [Andra (France)

    2009-06-15

    In accordance with the Planning Act of 28 June 2006, the French National Radioactive Waste Management Agency (Agence nationale pour la gestion des dechets radioactifs - ANDRA) is currently investigating the possibility of disposing of high-level (HL) and intermediate-level long-lived (IL/LL) radioactive waste in a deep geological formation. The waste inventory intended for geological disposal is significant and represents approximately 80,000 m{sup 3} of primary waste. The required drifts and cells for such disposal are developing in a long and complex network, with plans calling for a total of about 300 km of drifts to be opened over the next century. This paper describes various issues relating to the architecture design and the way they are integrated. Long-term safety is at the basis of the major principles not only for dividing the different waste categories into separate disposal areas, but also for identifying the relevant constraints involving the topology of the network (fragmentation of disposal areas into modules, dead-end architecture) and the orientation of certain structures. In the case of exothermal waste, since the control over the phenomenological evolution also leads to selecting a thermal criterion in the geological layer in contact with the waste, there is an impact on the density of the repository and, consequently, on its architecture. Operational security and safety issues are reflected in ventilation needs and in personnel-evacuation requirements in case of fire, both of which require additional intersections and drifts. The section of drifts is also conditioned often by those security aspects. Nuclear zoning may also induce requirements for special structures having a potential impact on the architecture. Operation, taken into its broader sense encompassing construction and nuclear activities, imposes its own share of constraints quite independently from any security or safety considerations. Impacted areas include structure slopes, the

  13. Centrally administered urocortin 2 decreases gorging on high-fat diet in in both diet induced obesity-prone and -resistant rats

    Science.gov (United States)

    Cottone, Pietro; Sabino, Valentina; Nagy, Tim R.; Coscina, Donald V.; Levin, Barry E.; Zorrilla, Eric P.

    2013-01-01

    Objective Obesity is a costly, deadly public health problem for which new treatments are needed. Individual differences in meal pattern have been proposed to play a role in obesity risk. The present study tested the hypothesis that i) the microstructure of chronic high-fat diet intake differs between genetically selected Diet-Induced Obesity (DIO) and Diet Resistant (DR) rats, and ii) central administration of urocortin 2 (Ucn 2), a corticotropin-releasing factor type 2 (CRF2) agonist, decreases high-fat diet intake not only in lean DR rats, but also in obese DIO rats. Design Male, selectively bred DIO and DR rats (n=10/genotype) were chronically fed a high-fat diet. Food and water intake as well as ingestion microstructure were then compared under baseline conditions and following third intracerebroventricular injection of Ucn 2 (0, 0.1, 0.3, 1, 3 µg). Results Irrespective of genotype, Ucn 2 reduced nocturnal food intake with a minimum effective dose of 0.3 µg, suppressing high-fat diet intake by ~40% at the 3 µg dose. Ucn 2 also made rats of both genotypes eat smaller and briefer meals, including at doses that did not reduce drinking. Obese DIO rats ate fewer but larger meals than DR rats, which they ate more quickly and consumed with 2/3rd less water. Conclusions Unlike leptin and insulin, Ucn 2 retains its full central anorectic efficacy to reduce high-fat diet intake even in obese, genetically-prone DIO rats, which otherwise show a “gorging” meal pattern. These results open new opportunities of investigation towards treating some forms of diet-induced obesity. PMID:23478425

  14. La ley del rey es la ley de dios: el deber ser de la institucion matrimonial durante la colonia

    Directory of Open Access Journals (Sweden)

    Tatiana Gonzalaez

    2014-02-01

    Full Text Available "La ley del rey es la ley de Dios" aborda el problema aborda el problema del deber ser de la institucion matrimonial que regia las millones de parejas en el Nuevo Mundo hasta mediados del siglo XVIII.

  15. O lugar a cultura política do aluno do Ensino Médio

    Directory of Open Access Journals (Sweden)

    Denilson Roberto Schena

    2012-03-01

    Full Text Available Relata uma pesquisa desenvolvida junto a alunos de terceiras séries do Ensino Médio do Colégio Estadual do Paraná. As reflexões realizadas neste artigo são decorrentes das atividades do projeto de intervenção pedagógica na escola denominado “O lugar da cultura política do aluno do Ensino Médio e sua relação com a aprendizagem histórica”. Este projeto teve sua origem ao contemplar uma das exigências do Programa de Desenvolvimento Educacional (PDE, edição 2008, programa de formação continuada da Secretaria de Estado da Educação do Paraná. A metodologia adotada fundamentou-se em pesquisa qualitativa, na forma de estudo de caso, tendo como técnicas a pesquisa documental e procedimentos de observação. Também foram utilizados inquéritos, entrevistas e questionários. O objetivo geral da pesquisa foi identificar o lugar da cultura política do aluno do Ensino Médio e sua relação com a aprendizagem histórica; os objetivos específicos foram identificar através do referencial teórico elementos que constituam alternativas metodológicas no ensino de História, tendo como referência as ideias dos jovens estudantes, valorizar a experiência social e política do aluno nas aulas de História e identificar o conceito de cultura política existente entre os jovens do Ensino Médio.Palavras-chave: Ensino de História; Educação Histórica; Cultura Política; Aprendizagem Histórica; Ensino Médio. [1] Mestre em Educação pela Universidade Federal do Paraná (UFPR, Professor de História do Instituto Federal do Paraná (IFPR – câmpus Curitiba. E-mail: denilson.schena@ifpr.edu.br

  16. Estimativas corrigidas de feminicídios no Brasil, 2009 a 2011

    Directory of Open Access Journals (Sweden)

    Leila Posenato Garcia

    2015-05-01

    Full Text Available OBJETIVO: Estimar as taxas de feminicídios corrigidas e apresentar o perfil desses óbitos no Brasil durante o triênio de 2009 a 2011. MÉTODOS: Foi realizado estudo descritivo com dados do Sistema de Informações sobre Mortalidade (SIM. Foram considerados como feminicídios os óbitos de mulheres cuja causa básica foi classificada nos códigos X85-Y09 da CID-10 (agressões. Esses dados foram corrigidos em duas etapas: redistribuição proporcional dos eventos cuja intenção é indeterminada (Y10-Y34 e aplicação de fatores de correção das taxas de mortalidade descritos anteriormente na literatura. RESULTADOS: No período analisado, foram registrados 13 071 feminicídios no SIM. Após a correção, estimou-se a ocorrência de 17 167 feminicídios, o que equivale a uma taxa de 5,86 óbitos por 100 000 mulheres. Taxas mais elevadas foram observadas nas regiões Nordeste, Centro-Oeste e Norte (6,93, 6,88 e 6,43 óbitos por 100 000 mulheres, respectivamente, enquanto as mais baixas foram nas regiões Sul e Sudeste (5,07 e 5,09 óbitos por 100 000 mulheres, respectivamente. Entre as vítimas, 29,7% tinham entre 20 e 29 anos; 60,9% eram negras; 48% daquelas com 15 ou mais anos de idade tinham até 8 anos de estudo. Houve envolvimento de armas de fogo em 50,2% das mortes; 27,6% ocorreram no domicílio e 35,1% aos finais de semana. CONCLUSÕES: As taxas de feminicídios foram elevadas e corroboram a necessidade de correção, visando a reduzir a subestimação. As vítimas foram mulheres de todas as faixas etárias, etnias e níveis de escolaridade. Todavia, as principais vítimas foram mulheres jovens, negras e com baixa escolaridade, residentes nas regiões Nordeste, Centro-Oeste e Norte.

  17. DIO: um jogo em dispositivos móveis para mapear câmeras de vigilância | DIO: a mobile game to map surveillance cameras

    OpenAIRE

    Rafael de Almeida Evangelista; Tiago Soares; Sarah Costa Schimidt; Felipe Lavignatti

    2016-01-01

    RESUMO Na sociedade contemporânea, as câmeras de vigilância são tecnologias de uso rápido e crescente. As razões dadas para essa proliferação estão principalmente relacionadas a preocupações com segurança. Nos países pobres, a ênfase está no controle da criminalidade urbana. Nos países ricos, elas são justificadas também pela ameaça do terrorismo. DIO é um jogo para celulares, ainda em desenvolvimento, que tematiza a proliferação das câmeras em áreas urbanas, promovendo um mapeamento colabora...

  18. Fontes de Sódio e Relação Sódio: Cloro para Frangos de Corte Sodium Chloride Levels in Broiler Diets

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    AV Fischer da Silva

    2000-04-01

    Full Text Available Foram utilizados 2.880 pintos de corte, para avaliar os efeitos de diferentes fontes de sódio (Na+ e relações sódio:cloro (Na+:Cl- na ração. As aves receberam ração e água ad libtum. O delineamento experimental foi inteiramente casualizado, com quatro tratamentos e seis repetições. O ganho de peso, consumo de ração, conversão alimentar e mortalidade não foram influenciados (p>0,05 pela substituição da fonte tradicional de Na e pelas diferentes relações Na:Cl. A umidade da cama foi afetada pela fonte e níveis de Na na ração. Os resultados mostraram que pode-se utilizar o NaHCO3 como fonte parcial à exigência de Na para frangos de corte de 1 a 47 dias de idade.A trial was carried out with 2,880 day old chicks to evaluate different sources of sodium (Na+ and Na+:Cl- ratio in diets. Water and diets were available in "ad libitum" feeding. Experimental design was completely randomized with four treatments and six repetitions. The performance (feed intake, body weight, feed conversion and mortality was not affected (P>0.05 by treatments, but different levels and sources of Na+ increased litter moisture. The NaHCO3 can be used in chicken broilers diets in partial substitution of Na for day 1 to 47.

  19. Myostatin-deficiency in mice increases global gene expression at the Dlk1-Dio3 locus in the skeletal muscle.

    Science.gov (United States)

    Hitachi, Keisuke; Tsuchida, Kunihiro

    2017-01-24

    Myostatin, a member of the transforming growth factor-beta superfamily, is a negative regulator of skeletal muscle growth and development. Myostatin inhibition leads to increased skeletal muscle mass in mammals; hence, myostatin is considered a potential therapeutic target for skeletal muscle wasting. However, downstream molecules of myostatin in the skeletal muscle have not been fully elucidated. Here, we identified the Dlk1-Dio3 locus at the mouse chromosome 12qF1, also called as the callipyge locus in sheep, as a novel downstream target of myostatin. In skeletal muscle of myostatin knockout mice, the expression of mature miRNAs at the Dlk1-Dio3 locus was significantly increased. The increased miRNA levels are caused by the transcriptional activation of the Dlk1-Dio3 locus, because a significant increase in the primary miRNA transcript was observed in myostatin knockout mice. In addition, we found increased expression of coding and non-coding genes (Dlk1, Gtl2, Rtl1/Rtl1as, and Rian) at the Dlk1-Dio3 locus in myostatin-deficient skeletal muscle. Moreover, epigenetic changes, associated with the regulation of the Dlk1-Dio3 locus, were observed in myostatin knockout mice. Taken together, this is the first report demonstrating the role of myostatin in regulating the Dlk1-Dio3 (the callipyge) locus in the skeletal muscle.

  20. A QCM-D study of the concentration- and time-dependent interactions of human LL37 with model mammalian lipid bilayers.

    Science.gov (United States)

    Lozeau, Lindsay D; Rolle, Marsha W; Camesano, Terri A

    2018-07-01

    The human antimicrobial peptide LL37 is promising as an alternative to antibiotics due to its biophysical interactions with charged bacterial lipids. However, its clinical potential is limited due to its interactions with zwitterionic mammalian lipids leading to cytotoxicity. Mechanistic insight into the LL37 interactions with mammalian lipids may enable rational design of less toxic LL37-based therapeutics. To this end, we studied concentration- and time-dependent interactions of LL37 with zwitterionic model phosphatidylcholine (PC) bilayers with quartz crystal microbalance with dissipation (QCM-D). LL37 mass adsorption and PC bilayer viscoelasticity changes were monitored by measuring changes in frequency (Δf) and dissipation (ΔD), respectively. The Voigt-Kelvin viscoelastic model was applied to Δf and ΔD to study changes in bilayer thickness and density with LL37 concentration. At low concentrations (0.10-1.00 μM), LL37 adsorbed onto bilayers in a concentration-dependent manner. Further analyses of Δf, ΔD and thickness revealed that peptide saturation on the bilayers was a threshold for interactions observed above 2.00 μM, interactions that were rapid, multi-step, and reached equilibrium in a concentration- and time-dependent manner. Based on these data, we proposed a model of stable transmembrane pore formation at 2.00-10.0 μM, or transition from a primarily lipid to a primarily protein film with a transmembrane pore formation intermediate state at concentrations of LL37 > 10 μM. The concentration-dependent interactions between LL37 and PC bilayers correlated with the observed concentration-dependent biological activities of LL37 (antimicrobial, immunomodulatory and non-cytotoxic at 0.1-1.0 μM, hemolytic and some cytotoxicity at 2.0-13 μM and cytotoxic at >13 μM). Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Response of clonogenic cells of mice solid tumour NKLy/LL to N-methyl-N-nitrosourea

    International Nuclear Information System (INIS)

    Chan Tik Kan; Afanas'ev, G.G.; Pelevina, I.I.

    1979-01-01

    By cloning in vitro the cells of NKLy/LL solid tumour of mice it has been shown that the curve of clonogenic cell survival versus N-methyl-N-nitrosourea (MNU) dose in the 12.5-200.0 mg/kg interval is exponential and characterized by Dsub(o)=29.15 mg/kg dose value. Large size tumours (15.0-17.0 g) are characterized by higher death rate of clonogenic cells (survivor fraction approximately 0.5%) than in 1.0-7.0 g tumours (survivor fraction 2-4%). That is, evidently, related to higher sensitivity of the resting tumour cells to MNU

  2. Uranium-lead Isotope Evidence in the Shelyabinsk LL5 Chondrite Meteorite for Ancient and Recent Thermal Events

    Science.gov (United States)

    Lapen, T. J.; Kring, D. A.; Zolensky, M. E.; Andreasen, R.; Righter, M.; Swindle, T. D.; Beard, S. P.; Swindle, T. D.

    2014-01-01

    The impact histories on chondrite parent bodies can be deduced from thermochronologic analyses of materials and isotope systems with distinct apparent closure temperatures. It is especially critical to better understand the geological histories and physical properties of potenally hazardous near-Earth asteroids. Chelyabinsk is an LL5 chondrite meteorite that was dispersed over a wide area tens of kilometers south of the town of Chelyabinsk, Russia by an explosion at an altitude of 27 km at 3:22 UT on 15 Feb 2013 [1,2]. The explosion resulted in significant damage to surrounding areas and over 1500 injuries along with meteorite fragments being spread over a wide area [1].

  3. The Effects of Spaceflight on the Rat Circadian Timing System

    Science.gov (United States)

    Fuller, Charles A.; Murakami, Dean M.; Hoban-Higgins, Tana M.; Fuller, Patrick M.; Robinson, Edward L.; Tang, I.-Hsiung

    2003-01-01

    Two fundamental environmental influences that have shaped the evolution of life on Earth are gravity and the cyclic changes occurring over the 24-hour day. Light levels, temperature, and humidity fluctuate over the course of a day, and organisms have adapted to cope with these variations. The primary adaptation has been the evolution of a biological timing system. Previous studies have suggested that this system, named the circadian (circa - about; dies - a day) timing system (CTS), may be sensitive to changes in gravity. The NASA Neurolab spaceflight provided a unique opportunity to evaluate the effects of microgravity on the mammalian CTS. Our experiment tested the hypotheses that microgravity would affect the period, phasing, and light sensitivity of the CTS. Twenty-four Fisher 344 rats were exposed to 16 days of microgravity on the Neurolab STS-90 mission, and 24 Fisher 344 rats were also studied on Earth as one-G controls. Rats were equipped with biotelemetry transmitters to record body temperature (T(sub b)) and heart rate (HR) continuously while the rats moved freely. In each group, 18 rats were exposed to a 24-hour light-dark (LD 12:12) cycle, and six rats were exposed to constant dim red-light (LL). The ability of light to induce a neuronal activity marker (c-fos) in the circadian pacemaker of the brain, the suprachiasmatic nucleus (SCN), was examined in rats studied on flight days two (FD2) and 14 (FD14), and postflight days two (R+1) and 14 (R+13). The flight rats in LD remained synchronized with the LD cycle. However, their T(sub b), rhythm was markedly phase-delayed relative to the LD cycle. The LD flight rats also had a decreased T(sub b) and a change in the waveform of the T(sub b) rhythm compared to controls. Rats in LL exhibited free-running rhythms of T(sub b), and HR; however, the periods were longer in microgravity. Circadian period returned to preflight values after landing. The internal phase angle between rhythms was different in flight than

  4. TOWARDS SOCIOLOGY OF MUSIC: FROM THE SCIENTIFIC HERITAGE OF L.L. SABANEEV

    Directory of Open Access Journals (Sweden)

    V. G. Lukianov

    2017-01-01

    Full Text Available The author analyzes the ideas of L.L. Sabaneev (1881–1968 – Professor of Moscow University, a well-known Russian musicologist, music critic, pianist and composer who emigrated in 1926. His theoretical ideas remain almost unexplored. However, his works on the theory and history of music are still interesting: he substantiated the need of sociological approach to the study of music and the analysis of music in context of social life. Unlike his contemporaries, musicologists (A.V. Lunacharsky, B.V. Asafiev, R.I. Gruber, etc., who, although set the task of the development of the sociological approach, but did not implement it at once, Sabaneyev published his works on the history of music in the mid 20-ies, he tried to reveal this problem on the new methodological basis. The article shows that, Sabaneev suggested to renew the methodology of domestic musicology in the 20-ies of the XX century. Sabaneev developed a special conceptual apparatus (“production” and “consumption” of music, “the environment or the consumer of the musical arts”, “musical (sound consciousness”, “taste group”, “style” – individual, group, “school style”, “style of the epoch”, etc., by means of which he was able to realize the task of development of the sociological approach in musicology. There presented a statement that the introduction by Sabaneev such terms as “impression of the spirit”, “a type of feeling”, “world vision”, “musical vision”, “audible world perception”, “world outlook” in many ways anticipates the modern idea of picture of the world (which includes three components – world outlook, world perception and worldview, which finds its embodiment in the work of art. Sabaneev’s effort to present a typology of music listeners, which turned out to be innovative in its time became valuable for the present stage of sociology of music development. Much later T.W. Adorno put the

  5. Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation

    Directory of Open Access Journals (Sweden)

    C.D. Cisternas

    2010-09-01

    Full Text Available We studied the effects of adverse conditions such as constant light (LL on the circadian rhythm of malate (MDH, EC 1.1.1.37 and lactate (LDH, EC 1.1.1.27 dehydrogenase activities of the testes of male Wistar rats on postnatal day 28 (PN28, anxiety-like behavior (elevated plus-maze test at PN60 and sexual behavior at PN120. The rats were assigned to mother groups on day 10 of pregnancy: control (12-h light/dark, LL (light from day 10 to 21 of pregnancy, and LL+Mel (LL and sc injection to the mothers of a daily dose of melatonin, 1 mg/kg body weight at circadian time 12, from day 17 to 21 of pregnancy. LL offspring did not show circadian rhythms of MDH (N = 62 and LDH (N = 63 activities (cosinor and ANOVA-LSD Fisher. They presented a 44.7% decrease in open-arm entries and a 67.9% decrease in time (plus-maze test, N = 15, P < 0.001, Mann-Whitney U-test and Kruskal-Wallis test, an increase in mounting (94.4%, intromission (94.5% and ejaculation (56.6% latencies (N = 12, P < 0.01, Mann-Whitney U-test and Kruskal-Wallis test and lower numbers of these events (61, 59 and 73%, respectively; P < 0.01, N = 12 compared to controls. The offspring of the LL+Mel group presented MDH and LDH circadian rhythms (P < 0.05, N = 50, cosinor and ANOVA-LSD Fisher, anxiety-like and sexual behaviors similar to control. These findings supported the importance of the melatonin signal and provide evidence for the protective effects of hormones on maternal programming during gestation. This protective action of melatonin is probably related to its entrainment capacity, favoring internal coupling of the fetal multioscillatory system.

  6. An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity.

    Science.gov (United States)

    Wan, Xinyue; Yin, Jieyun; Foreman, Robert; Chen, Jiande D Z

    2017-12-01

    This paper aims to optimize stimulation parameters and durations for intestinal electrical stimulation (IES) and to explore the effects and mechanisms of chronic IES with optimized methodology in obesity rats. Sixteen diet-induced obese (DIO) rats were tested for food intake with four different sets of IES parameters each lasting 1 week. Then, another 12 DIO rats were used to test the effect of IES on food intake with different stimulation durations. Finally, 16 DIO rats were treated with IES or sham-IES for 4 weeks. Meal patterns, food intake, and body weight were observed. Mechanisms involving gastrointestinal motility, ghrelin, and glucagon-like peptide-1 (GLP-1) were studied. (1) Acute IES with different parameters showed different inhibitory effects on food intake, and the most effective parameters were 0.6 s on, 0.9 s off, 80 Hz, 2 ms, and 4 mA with which 26.3% decrease in food intake was noted (p fasting and postprandial plasma levels of GLP-1 but not ghrelin. Twelve-hour daily IES using optimized stimulation parameters reduces food intake and body weight in DIO rats by altering gastrointestinal motility and GLP-1. The IES methodology derived in this study may have a therapeutic potential for obesity.

  7. Lazareto de Agua de Dios, Frente a los Valores Sociales Invertidos // Lazareto de Agua de Dios, in Front of Invested Social Securities // Lazareto Água de Dios, Contra a Valores Sociais Investidos

    Directory of Open Access Journals (Sweden)

    Darío Benavides Pava

    2016-12-01

    Full Text Available El presente artículo forma parte del proyecto de investigación institucional denominado Historiografía del Empresariado de Cundinamarca 1900-2010; Capítulo: Provincia del Alto Magdalena. Con este estudio se pretende hacer un merecido reconocimiento al empresariado de la provincia que, con su esfuerzo y tenacidad lograron hacer del Alto Magdalena una región próspera, foco de inversión nacional y extranjera. De igual manera, interesa a la academia analizar los modelos y técnicas administrativas empleados por los emprendedores locales en el empeño por sacar adelante sus proyectos. Este estudio lleva a cabo una secuencia documental de carácter histórico que permite conocer el modelo administrativo implementado en el Lazareto de Agua de Dios y su particular sistema económico, dando ejemplo de funcionalidad con respeto por la dignidad humana. Fue de esta manera como la sociedad resolvió “el problema”. 

  8. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    Directory of Open Access Journals (Sweden)

    Karen Amaral Tavares Pinheiro

    2011-09-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalência dos episódios depressivos e bipolares em homens no período pré e pós-natal, assim como 12 meses após o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. Episódios depressivos e maníacos/hipomaníacos foram mensurados com o Mini Neuropsychiatric Interview em três tempos diferentes: entre a 28ª e 34ª semanas de gestação (T1, 30 a 60 dias após o parto (T2 e 12 meses após o nascimento da criança. RESULTADOS: A prevalência de episódios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3

  9. Sacrifício rei, estado ruandês e genocídio

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    Christopher C. Taylor

    Full Text Available Em contraste com as análises do genocídio ruandês de 1994, que privilegiam o político, este artigo sustenta que o poder e a política durante o tempo que precedeu o genocídio foram afetadas por noções ruandesas específicas de cosmologia e ontologia. Para entender esse componente "imaginário" da violência, precisamos examinar atentamente as crenças e práticas relacionadas com a instituição da realeza sagrada em Ruanda. Embora essas crenças e práticas foram oficialmente encerradas em 1931, quando o último rei de Ruanda sagrado foi deposto e substituído por seu filho educado por missionários, a sua matriz cosmológica manteve-se em tempos recentes. Isto pode ser visto na literatura popular de rua Ruandesa, que circulou amplamente nos dias que antecederam o genocídio. Nessa literatura, o então presidente Juvenal Habyarimana era comparado explicitamente a um rei ruandês. Mais importante ainda para os objetivos deste artigo, foi a comparação mais difusa, implícita, e simbólica entre Habyarimana e um rei sagrado. Em particular, alguns dos elementos-chave neste simbolismo iluminam (e mostram a importância da persistência da imagem de como um rei (ou presidente deveria se comportar. Como havia muitos jornalistas ruandeses reacionários (e racistas que tinham começado a duvidar da capacidade do presidente Habyarimana de ser um "bom rei", seu "sacrifício"'subseqüente estava, em um sentido simbólico, fortemente predestinado.

  10. Revisão de literatura sobre suicídio na infância

    Directory of Open Access Journals (Sweden)

    Girliani Silva de Sousa

    Full Text Available Resumo Objetivou-se analisar a literatura específica sobre os fatores associados ao comportamento suicida em crianças com até 14 anos. Trata-se, portanto, de uma revisão integrativa sobre este tema. Os dados foram coletados nas bases de dados PubMed e Psycinfo, a partir dos seguintes descritores: “risk of suicide”; “children”; “suicide”; “childhood”. O tempo de publicação foi limitado ao período de 1980 a 2016. Um total de 29 artigos preencheu os critérios de elegibilidade e, portanto, foram selecionados e analisados. Os resultados indicaram haver associação do suicídio com fatores neurobiológicos, escolares, sociais e mentais, dentre eles destaca-se o papel da impulsividade. Além disso, evidenciou-se que a maioria dos fatores de vulnerabilidade ao comportamento suicida podem ser prevenidos desde que sejam identificados e a criança receba tratamento psicológico e médico. Conclui-se que conflitos familiares, problemas na escola, bullying, impulsividade e depressão estão associados ao suicídio na infância. Adicionalmente, a escassez de pesquisas no âmbito nacional acerca da temática do suicídio pode contribuir para a invisibilidade desse tema na instauração de programas de promoção e tratamento de saúde.

  11. Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat

    Czech Academy of Sciences Publication Activity Database

    Trnovská, J.; Šilhavý, Jan; Zídek, Václav; Šimáková, Miroslava; Mlejnek, Petr; Landa, Vladimír; Eigner, Sebastian; Eigner-Henke, Kateřina; Škop, V.; Oliyarnyk, O.; Kazdová, L.; Mráček, Tomáš; Houštěk, Josef; Pravenec, Michal

    2015-01-01

    Roč. 64, č. 1 (2015), s. 51-60 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GB14-36804G; GA ČR(CZ) GA13-04420S; GA MŠk(CZ) LL1204; GA MZd(CZ) NT14325 Institutional support: RVO:67985823 ; RVO:61389005 Keywords : gender * hairless rat * metabolism * brown adipose tissue Subject RIV: ED - Physiology Impact factor: 1.643, year: 2015

  12. Mapping genetic determinants of coronary microvascular remodeling in the spontaneously hypertensive rat

    Czech Academy of Sciences Publication Activity Database

    Mancini, M.; Petretto, E.; Kleinert, C.; Scavone, A.; De, T.; Cook, S.; Šilhavý, Jan; Zídek, Václav; Pravenec, Michal; d´Amati, G.; Camici, P.G.

    2013-01-01

    Roč. 108, č. 1 (2013), s. 316 ISSN 0300-8428 R&D Projects: GA MŠk(CZ) LH11049; GA MŠk(CZ) LL1204; GA ČR(CZ) GAP301/12/0696 Institutional support: RVO:67985823 Keywords : arterial hypertension * coronary circulation * myocardial ischemia * spontaneously hypertensive rat * recombinant inbred strains Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.955, year: 2013

  13. Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats

    Czech Academy of Sciences Publication Activity Database

    Klevstig, M.; Manakov, D.; Kašparová, D.; Brabcová, I.; Papoušek, František; Žurmanová, J.; Zídek, Václav; Šilhavý, Jan; Neckář, Jan; Pravenec, Michal; Kolář, František; Nováková, O.; Novotný, J.

    2013-01-01

    Roč. 465, č. 10 (2013), s. 1477-1486 ISSN 0031-6768 R&D Projects: GA MŠk(CZ) LL1204; GA AV ČR(CZ) IAAX01110901; GA ČR(CZ) GAP303/10/0505 Institutional support: RVO:67985823 Keywords : SHR rats * Cd36 * heart * beta-Adrenergic receptors * Adenylyl cyclase * Protein kinase A Subject RIV: ED - Physiology Impact factor: 3.073, year: 2013

  14. Zerstören oder Bewahren? Umgang mit kulturellem Erbe bel H. Böll und E. Loest

    Directory of Open Access Journals (Sweden)

    Helmut Galle

    2003-12-01

    Full Text Available O artigo descreve e analisa como dois importantes autores de oposição intelectual na Alemanha Ocidental (Böll e Oriental (Loest reconstroem, cada um para sua sociedade, as atitudes dominantes frente ao patrimônio cultural e arquitetônico. Em cada caso, as atitudes das elites do poder diferem daquelas dos opositores: Na RFA, o governo, em geral, preserva os monumentos, fingindo uma continuidade histórica; na RDA, o governo destrói palácios e igrejas para romper com as tradições. Os autores simpatizam com os opositores: Böll, no oeste, enfatiza a necessidade de destruir o patrimônio cultural para recuperar a função memorativa do mesmo, enquanto Loest opta pela resistência contra a política oficial da destruição no leste. A preservação de monumentos históricos é vista, em ambos os casos, em função das necessidades da geração atual, não como valor em si mesmo.

  15. Liposakşın Yöntemiyle Jinekomasti Tedavisi: 8 Yıllık Deneyim

    OpenAIRE

    Çil, Yakup

    2015-01-01

    Amaç: Jinekomasti erkeklerde görülen patolojik meme büyüklüğünü olarak tanımlanmaktadır. Jinekomastinin temel tedavi yöntemi cerrahidir. Son yıllarda liposakşın yönteminde jinekomastinin cerrahi tedavisinde kullanılmaya başlanmıştır. Burada 8 yıllık dönemde liposakşın yöntemi ile tedavi edilen jinekomastili hastaların sonuçları sunuldu. Yöntem ve Gereçler: Çalışmada; 2006-2014 yılları arasındaki 8 yıllık dönemde jinekomasti nedeniyle liposakşın yöntemi ile tedavi edilen yaş ortalaması 23 yıl...

  16. Biochemical characterization of recombinant cinnamoyl CoA reductase 1 (Ll-CCRH1) from Leucaena leucocephala.

    Science.gov (United States)

    Sonawane, Prashant; Vishwakarma, Rishi Kishore; Khan, Bashir M

    2013-07-01

    Recombinant cinnamoyl CoA reductase 1 (Ll-CCRH1) protein from Leucaena leucocephala was overexpressed in Escherichia coli BL21 (DE3) strain and purified to apparent homogeneity. Optimum pH for forward and reverse reaction was found to be 6.5 and 7.8 respectively. The enzyme was most stable around pH 6.5 at 25°C for 90 min. The enzyme showed Kcat/Km for feruloyl, caffeoyl, sinapoyl, coumaroyl CoA, coniferaldehyde and sinapaldehyde as 4.6, 2.4, 2.3, 1.7, 1.9 and 1.2 (×10(6) M(-1) s(-1)), respectively, indicating affinity of enzyme for feruloyl CoA over other substrates and preference of reduction reaction over oxidation. Activation energy, Ea for various substrates was found to be in the range of 20-50 kJ/mol. Involvement of probable carboxylate ion, histidine, lysine or tyrosine at the active site of enzyme was predicted by pH activity profile. SAXS studies of protein showed radius 3.04 nm and volume 49.25 nm(3) with oblate ellipsoid shape. Finally, metal ion inhibition studies revealed that Ll-CCRH1 is a metal independent enzyme. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. Physiologically-Relevant Modes of Membrane Interactions by the Human Antimicrobial Peptide, LL-37, Revealed by SFG Experiments

    Science.gov (United States)

    Ding, Bei; Soblosky, Lauren; Nguyen, Khoi; Geng, Junqing; Yu, Xinglong; Ramamoorthy, Ayyalusamy; Chen, Zhan

    2013-05-01

    Antimicrobial peptides (AMPs) could become the next generation antibiotic compounds which can overcome bacterial resistance by disrupting cell membranes and it is essential to determine the factors underlying its mechanism of action. Although high-resolution NMR and other biological studies have provided valuable insights, it has been a major challenge to follow the AMP-membrane interactions at physiologically-relevant low peptide concentrations. In this study, we demonstrate a novel approach to overcome this major limitation by performing Sum Frequency Generation (SFG) vibrational spectroscopic experiments on lipid bilayers containing an AMP, LL-37. Our results demonstrate the power of SFG to study non-linear helical peptides and also infer that lipid-peptide interaction and the peptide orientation depend on the lipid membrane composition. The observed SFG signal changes capture the aggregating process of LL-37 on membrane. In addition, our SFG results on cholesterol-containing lipid bilayers indicate the inhibition effect of cholesterol on peptide-induced membrane permeation process.

  18. Identification of Secreted Proteins Involved in Nonspecific dsRNA-Mediated Lutzomyia longipalpis LL5 Cell Antiviral Response

    Directory of Open Access Journals (Sweden)

    Andrea Martins-da-Silva

    2018-01-01

    Full Text Available Hematophagous insects transmit infectious diseases. Sand flies are vectors of leishmaniasis, but can also transmit viruses. We have been studying immune responses of Lutzomyia longipalpis, the main vector of visceral leishmaniasis in the Americas. We identified a non-specific antiviral response in L. longipalpis LL5 embryonic cells when treated with non-specific double-stranded RNAs (dsRNAs. This response is reminiscent of interferon response in mammals. We are investigating putative effectors for this antiviral response. Secreted molecules have been implicated in immune responses, including interferon-related responses. We conducted a mass spectrometry analysis of conditioned medium from LL5 cells 24 and 48 h after dsRNA or mock treatment. We identified 304 proteins. At 24 h, 19 proteins had an abundance equal or greater than 2-fold change, while the levels of 17 proteins were reduced when compared to control cells. At the 48 h time point, these numbers were 33 and 71, respectively. The two most abundant secreted peptides at 24 h in the dsRNA-transfected group were phospholipid scramblase, an interferon-inducible protein that mediates antiviral activity, and forskolin-binding protein (FKBP, a member of the immunophilin family, which mediates the effect of immunosuppressive drugs. The transcription profile of most candidates did not follow the pattern of secreted protein abundance.

  19. Plan de Comunicación de Aldaia Ràdio

    OpenAIRE

    Fornés Garrido, Raúl

    2011-01-01

    El presente Trabajo Final de Carrera constituye un estudio general para la elaboración de un plan de comunicación para la empresa radiofónica municipal Aldaia Ràdio. El plan de comunicación de cualquier organización empresarial se compone de un sinfín de elementos, tanto internos como externos, que desarrollándolos, constituyen la plataforma de proyección de la imagen de una empresa de forma eficiente. Este estudio pretende contribuir a mejorar la imagen, difusión y comercialización de l...

  20. Metáforas sobre el exilio en "Dios nos quiere contentos" de Griselda Gambarro.

    Directory of Open Access Journals (Sweden)

    Ariadna Castellarnau

    2010-01-01

    Full Text Available El presente artículo analiza la novela Dios no nos quiere contentos, de la escritora argentina Griselda Gambaro, desde la perspectiva de la literatura de exilio. Esto significa trazar una lectura de la obra no tanto desde lo vivencial (como trasunto literario de la propia experiencia de la autora como desterrada durante el período de la última dictadura militar argentina como desde lo universal: analizando la experiencia del exilio como un hecho en abstracto, aplicable a cualquier contexto nacional e histórico, a través de las metáforas sobre las que trabaja Gambaro.

  1. ABORDAGEM DO BIOMA CERRADO EM LIVROS DIDÁTICOS DE BIOLOGIA DO ENSINO MÉDIO

    OpenAIRE

    Rafael Gonçalves Bezerra; Rodrigo Capelle Suess

    2013-01-01

    A educação brasileira tem os livros didáticos como principal recurso de informação a alunos e professores. Este trabalho analisa como ocorre a abordagem do bioma Cerrado em seis livros didáticos de biologia destinados ao Ensino Médio. Os aspectos analisados foram o número de páginas destinadas ao tema, figuras, exemplificações acerca da fauna e flora local e abordagem do tema. A análise mostrou que todos os aspectos são apresentados de maneira resumida. Exemplos da fauna e flora local, quando...

  2. “Mai, inteso nominare”. La citazione in “Dio ne scampi dagli Orsenigo"

    Directory of Open Access Journals (Sweden)

    Sandra Carapezza

    2015-06-01

    Full Text Available In Dio ne scampi dagli Orsenigo Vittorio Imbriani grapples with the form of the novel. In a dialectical fashion, explicit quotations (frequently from French sources clarify his position towards generic paradigms. This article attempts to group these quotations on the basis of their literary genres in order to stress the complexities of an inclusive and versatile text. The intertextual network, ranging from feuilleton literature to academic preciosity, in the last instance reveals itself as an ironic antidote to Romantic identification. This trend is confirmed by the remarkable increase in the number of quotations from the first edition (1876 to the second publication in volume form in 1883.

  3. Etnia y tradición religiosa: adoraciones nortecaucanas del Niño Dios

    Directory of Open Access Journals (Sweden)

    Heliana Portes de Roux

    1986-04-01

    Full Text Available En los primeros meses de cada año los pobladores negros de muchas localidades del norte del departamento del Cauca y del sur del departamento del Valle, celebran las adoraciones del Niño Dios. Las adoraciones -como se las suele denominar- constituyen la manifestación religiosa más importante de la población negra de la región, tanto por su arraigo en la tradición como por la connotación social que tienen.

  4. O assédio moral na enfermagem: contributos para a gestão organizacional

    OpenAIRE

    Marques, Patrícia Sofia da Assunção

    2014-01-01

    Dissertação de mestrado em Gestão das Organizações: Ramo de Gestão de Unidades de Saúde (parceria com a APNOR) apresentada na Escola Superior de Saúde do Instituto Politécnico de Viana do Castelo O presente estudo aborda a temática do assédio moral em enfermagem, através de uma metodologia qualitativa de natureza descritiva fenomenológica. Pretende compreender o contexto laboral em que ocorre o fenómeno, analisar os elementos que directamente nele intervêm e conhecer e dar a conhe...

  5. Cordero de Dios: el sacrificio, la justicia y el retorno de lo reprimido

    Directory of Open Access Journals (Sweden)

    Pablo Ortemberg

    2008-06-01

    Full Text Available 1. Cordero de Dios (Agnus Dei, en Francia es un drama familiar que se presenta indisociable del drama histórico argentino. Guillermina, una joven de 30 años, recibe el llamado de los secuestradores de su querido abuelo Arturo, un veterinario todavía en actividad. En la Argentina del 2002, donde los estragos de la crisis provocaron, entre otras cosas, un aumento de la criminalización, las razones del secuestro son puramente económicas. Guillermina pide a su madre, Teresa, que regrese de Parí...

  6. An Interview with Professor Melquíades de Dios Leyva, December 2008

    Science.gov (United States)

    Arias de Fuentes, Olimpia

    When writing about the history of physics in Cuba, this remarkable professor of quantum mechanics must be mentioned, for he embodies a most genuine example of the turn taken by national educational policy after 1959: Education for all, at all levels, with no discrimination or elitism. The following is an interview granted by Dr. Melquíades de Dios Leyva, Outstanding Full Professor of the Physics Faculty of the University of Havana, to Dr. Olimpia Arias de Fuentes, Associate Professor at the same, and Senior Researcher of the Institute of Materials Science and Technology (IMRE) of the University of Havana.

  7. O assédio moral organizacional à luz da psicodinâmica do trabalho

    OpenAIRE

    Spack, Rodolfo Rigon

    2013-01-01

    Resumo: Através dessa monografia pretendemos discutir a questão do assédio moral organizacional como prática sistemática da organização do trabalho, violência que decorre do poder diretivo do empregador, expresso na forma jurídica do jus variandi. Mostramos como o abuso desse poder deverá ser limitado pelos direitos fundamentais, especialmente pela dignidade da pessoa humana. Para tanto, traçamos um histórico da violência moral no ambiente de trabalho, e de seu combate através das reinvindica...

  8. La teología desafiada por un Dios que se hace historia

    Directory of Open Access Journals (Sweden)

    Sergio Silva

    2011-01-01

    Full Text Available El artículo parte afirmando el carácter histórico de la teología, que le viene por el hecho de ser obra de seres humanos. Es histórico todo ser que está en devenir, lo que implica estar siendo, en relación con el entorno, desde un centro interior de conciencia y libertad, capaz de decidir. usando una analogía musical, la teología es histórica no solo porque su intérprete, el ser humano, es histórico, sino también y sobre todo porque su tema lo es: el Dios que se encarna y, así, se hace historia. De aquí los dos desafíos que aborda el artículo: a ¿Qué hace posible en Dios y en la historia humana que Dios se haga historia, es decir, que pueda devenir-en-interacción-con-los-demás-en-dirección-a-un-porvenir? La respuesta fundamental es, en Dios, que Él es Trinidad, es decir, que "deviene" con otros. Y, en la historia, el acto creador, como un poner al sujeto que puede acoger una autocomunicación de Dios fuera de sí. b ¿Cómo ha de ser la teología que piense adecuadamente este hacerse historia de Dios y cómo ha de ser el lenguaje en que se exprese esa teología? La teología debe dirigirse a los contemporáneos, porque ellos son los que experimentan el deseo de Dios puesto en ellos por el acto creador, deseo al que la teología aporta la respuesta de la revelación; debe pensar hoy al Dios testimoniado en la Escritura, el que ya se ha hecho historia; y debe buscar no tanto fijar naturalezas cuanto mostrar estructuras del devenir. El lenguaje de la teología no puede ser directo, denotativo, porque a Dios nadie lo ha visto nunca, sino indirecto, connotativo; de aquel se dan dos ejemplos: el lenguaje de Jesús en los evangelios y la propuesta de Guardini de un lenguaje indirecto, como el único capaz de asir lo viviente concreto.This article begins by affirming the historical character of theology, which comes from the fact of being the work of human beings. All beings are historic who are in the process of becoming, which

  9. Três fórmulas para compreender "O suicídio" de Durkheim

    OpenAIRE

    Teixeira, Ricardo Rodrigues

    2002-01-01

    Trata-se de um ensaio de interpretação da sociologia durkheimiana, a partir de uma breve contextualização de seu pensamento no quadro de uma certa visão da modernidade e de uma particular leitura de sua obra "O Suicídio". Dividido em três partes, o texto procura explorar alguns sentidos desta Sociologia, ao mesmo tempo que expõe uma de suas possíveis aporias. This is an essay interpreting the sociology of Durkheim, based on a brief contextualization of his thoughts within the scope of a gi...

  10. Subsídios para o monitoramento de formigas cortadeiras em plantios florestais no Planalto Catarinense

    OpenAIRE

    Hoffer, Hadson

    2015-01-01

    O objetivo deste trabalho foi fornecer subsídios para o monitoramento de formigas cortadeiras em plantios florestais no Planalto Catarinense, conhecendo as espécies de formigas cortadeiras da região, sua associação com o tipo de solo e a distribuição espaço-temporal dos danos causados em Pinus taeda. Para isso foram percorridos plantios florestais em sete municípios do Planalto Catarinense na busca por ninhos de formigas cortadeiras. As coletas ocorreram em cinco diferentes tipos de solo com ...

  11. Oh, the places you'll go! My many colored serotonin (apologies to Dr. Seuss)

    Science.gov (United States)

    2016-01-01

    Serotonin [5-hydroxytryptamine (5-HT)] has a truly fascinating history in the cardiovascular world. Discovered in the blood, 5-HT has long been appropriately regarded as a vasoconstrictor. A multitude of in vitro studies of isolated vessels support that addition of 5-HT causes vascular contraction. In only a few cases was 5-HT a vasodilator. Moreover, the potency and threshold of 5-HT causing contraction is increased in arteries from hypertensive vs. normotensive subjects, both animal and human. As such, we and others have hypothesized that 5-HT would contribute to hypertension by elevating arterial tone. In stark contrast to these decades of findings, we observed that a chronic infusion of 5-HT into conscious rats caused a reduction in blood pressure and nearly normalized blood pressure of experimentally hypertensive rats. Going back to the early work of Irvine Page, one of the scientists who discovered 5-HT, reveals an early recognized but never understood ability of 5-HT to reduce systemic blood pressure. Our laboratory, in collaboration with colleagues around the world, has dedicated itself to understanding the mechanisms of 5-HT-induced reduction in blood pressure. This manuscript takes you through a brief history of the discovery of 5-HT, in vitro serotonergic pharmacology of blood vessels, in vivo work with 5-HT and our studies that suggests the venous vasculature, potentially in combination with small arterioles, may be important to the actions of 5-HT in reducing blood pressure. 5-HT has certainly ended up in a place I never expected it to go. PMID:27663771

  12. Evaluation of the cardiotoxicity and resuscitation of rats of a newly developed mixture of a QX-314 analog and levobupivacaine

    Directory of Open Access Journals (Sweden)

    Wang Q

    2017-03-01

    Full Text Available Qi Wang,1 Qinqin Yin,1 Jun Yang,2 Bowen Ke,2 Linghui Yang,2 Jin Liu,1,2 Wensheng Zhang1,2 1Department of Anesthesiology, 2Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China Objective: This study was designed to evaluate the cardiotoxicity of a QX-314 analog (QX-OH and a mixture of QX-OH and levobupivacaine (LL-1 and to compare the ability to resuscitate rats after asystole induced by levobupivacaine (Levo-BUP, QX-314, QX-OH, and LL-1.Methods: First, we used the “up-and-down” method to determine median dose resulting in appearance of cardiotoxicity (CD50C and asystole (CD50A of Levo-BUP, QX-314, QX-OH, and LL-1 in rats. Safety index (SI; ratio of CD50C compared with 2-fold median effective dose needed to produce sensory blockade of the 4 drugs was calculated. Isobolograms were used for drug interaction analysis. Second, rats received 1.2-fold CD50A in the 4 groups. When asystole occurred, standard cardiopulmonary resuscitation was started and continued for 30 min or until return of spontaneous circulation (ROSC with native rate–pressure product ≥30% baseline for 5 min.Results: Ranking of CD50C was Levo-BUP < QX-314 ≈ QX-OH. Ranking of CD50A was Levo-BUP < QX-314 < QX-OH. However, the SI of Levo-BUP was significantly higher than that of QX-314 (10.60 vs. 1.20 or QX-OH (10.60 vs. 1.44. The SI of LL-1 was similar to that of Levo-BUP. Nonsynergistic interaction was observed for cardiac effects between QX-OH and Levo-BUP. ROSC was attained initially by 8 of 8 rats in the Levo-BUP group, 3 of 8 in the QX-314 group, 6 of 8 in the QX-OH group, and 8 of 8 in the LL-1 group. Sustained recovery was achieved in the Levo-BUP group but not in the other groups.Conclusion: Levo-BUP and LL-1 are safer than QX-314 or QX-OH. Cardiac effects between QX-OH and Levo-BUP were nonsynergistic. Initial successful resuscitation could be

  13. Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.

    Directory of Open Access Journals (Sweden)

    Hany H Arab

    Full Text Available Alcohol consumption has been commonly associated with gastric mucosal lesions including gastric ulcer. Diosmin (DIO is a natural citrus flavone with remarkable antioxidant and anti-inflammatory features that underlay its protection against cardiac, hepatic and renal injuries. However, its impact on gastric ulcer has not yet been elucidated. Thus, the current study aimed to investigate the potential protective effects of DIO against ethanol-induced gastric injury in rats. Pretreatment with DIO (100 mg/kg p.o. attenuated the severity of ethanol gastric mucosal damage as evidenced by lowering of ulcer index (UI scores, area of gastric lesions, histopathologic aberrations and leukocyte invasion. These actions were analogous to those exerted by the reference antiulcer sucralfate. DIO suppressed gastric inflammation by curbing of myeloperoxidase (MPO and tumor necrosis factor-α (TNF-α levels along with nuclear factor kappa B (NF-κB p65 expression. It also augmented the anti-inflammatory interleukin-10 (IL-10 levels. Meanwhile, DIO halted gastric oxidative stress via inhibition of lipid peroxides with concomitant enhancement of glutathione (GSH, glutathione peroxidase (GPx and the total antioxidant capacity (TAC. With respect to gastric mucosal apoptosis, DIO suppressed caspase-3 activity and cytochrome C (Cyt C with enhancement of the anti-apoptotic B cell lymphoma-2 (Bcl-2 in favor of cell survival. These favorable actions were associated with upregulation of the gastric cytoprotective prostaglandin E2 (PGE2 and nitric oxide (NO. Together, these findings accentuate the gastroprotective actions of DIO in ethanol gastric injury which were mediated via concerted multi-pronged actions, including suppression of gastric inflammation, oxidative stress and apoptosis besides boosting of the antioxidant and the cytoprotective defenses.

  14. Variabilidade genética de Eugenia uniflora L. em remanescentes florestais em diferentes estádios sucessionais

    Directory of Open Access Journals (Sweden)

    Roberto Valmorbida Aguiar

    2013-04-01

    Full Text Available A compreensão da diversidade genética fornece elementos básicos sobre a dinâmica e funcionamento de populações, auxiliando na conservação e uso sustentável das espécies. Supõe-se que populações sucessionais precoces poderiam ser geneticamente mais diferenciadas do que populações sucessionais mais tardias. Visando testar esta hipótese, o presente trabalho teve como objetivo analisar a variabilidade genética de populações de Eugenia uniflora L. em manchas florestais em diferentes estádios sucessionais. Foram selecionadas duas áreas em diferentes estádios de sucessão, sendo a primeira em estádio inicial e a segunda em estádio avançado. A área de estudo apresenta um remanescente florestal em transição de Floresta Ombrófila Mista e Floresta Estacional Semidecídua. Por meio da técnica de RAPD (Random Amplified Polymorphic DNA e análise multivariada, a diversidade gênica esperada e a porcentagem de loci polimórficos foram estimadas, além da similaridade genética entre as populações de cada mancha florestal e a diversidade de cada área por meio do índice de diversidade de Simpson. Os resultados indicaram 79% de loci polimórficos para a área em estádio avançado e 70% para a área em estádio inicial de sucessão. A similaridade genética entre pares de indivíduos variou entre 0,55 e 0,86 na área em estádio inicial de sucessão e entre 0,45 e 0,78 para a área em estádio avançado. Não houve diferenças significativas entre a diversidade das duas áreas (P = 89. Um escalonamento multidimensional não-métrico indicou menor distância genética entre os indivíduos da área em estádio inicial. Da mesma forma, uma análise de similaridade - ANOSIM indicou separação entre os indivíduos das duas áreas.

  15. Spontaneous motor activity during the development and maintenance of diet-induced obesity in the rat.

    Science.gov (United States)

    Levin, B E

    1991-09-01

    More than 80% of most daily spontaneous activities (assessed in an Omnitech activity monitor) occurred during the last hour of light and 12 h of the dark phase in 8 chow-fed male Sprague-Dawley rats. Thirty additional rats were, therefore, monitored over this 13-h period to assess the relationship of activity to the development and maintenance of diet-induced obesity (DIO) on a diet high in energy, fat and sucrose (CM diet). Nine of 20 rats became obese after 3 months on the CM diet, with 71% greater weight gain than 10 chow-fed controls. Eleven of 20 rats were diet resistant (DR), gaining the same amount of weight as chow-fed rats. Neither initial activity levels nor initial body weights on chow (Period I) differed significantly across retrospectively identified groups. After 3 months on CM diet or chow (Period II), as well as after an additional 3 months after CM diet-fed rats returned to chow (Period III), there were significant inverse correlations (r = -.606 to -.370) between body weight at the time of testing and various measures of movement in the horizontal plane. There was no relationship to dietary content nor consistent correlations of body weight or diet group to vertical movements, an indirect measure of ingestive behavior. Patterns of time spent in the vertical position were significantly different for DIO vs. DR rats in Period III, however. Thus, differences in food intake and metabolic efficiency, rather than differences in nocturnal activity, are probably responsible for the greater weight gain in DIO-prone rats placed on CM diet.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Estudo retrospectivo de radiografias com fraturas rádio e ulna em cães

    Directory of Open Access Journals (Sweden)

    Robson Fortes Giglio

    2007-12-01

    Full Text Available Foram analisadas 528 radiografias simples de fraturas de rádio e ulna do arquivo do Serviço de Diagnostico por Imagem do Departamento de Cirurgia junto ao Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo realizadas no período de julho de 1999 a dezembro de 2005, selecionando-se os meses para análise de forma randomizada. Os principais resultados encontrados foram: Fraturas de rádio e ulna representam 20,9% do total encontradas, destas o tipo mais observado foi a transversal, tanto no rádio (75,5% quanto na ulna (76,6%. 87,1% das fraturas acometeram o rádio e a ulna. O terço distal foi o mais acometido foi o distal, tanto do rádio quanto da ulna (72,9% e 70,1%, respectivamente. Esquírolas ósseas foram observadas em 13,8% e desvio de eixo ósseo em 94,9% dos casos. 40,2% dos cães não possuíam raça definida. 34,3% dos cães possuíam idade entre seis meses a um ano.

  17. ASSÉDIO MORAL NA ATENÇÃO BÁSICA SEGUNDO OS PROFISSIONAIS DE ENFERMAGEM

    Directory of Open Access Journals (Sweden)

    Cristiani Garrido de Andrade

    Full Text Available ResumoObjetivou-se investigar como os profissionais de enfermagem compreendem o assédio moral, bem como identificar essas situações vivenciadas pelos profissionais dessa área, suas causas e consequências para a saúde desses trabalhadores. Trata-se de uma pesquisa exploratória, de natureza qualitativa, da qual participaram 15 profissionais de enfermagem atuantes em unidades de saúde da família, da cidade de João Pessoa, na Paraíba. A coleta de dados foi realizada no período de abril a maio de 2013 e ocorreu mediante uma entrevista gravada. Os dados foram analisados por meio da técnica de análise de conteúdo. Da análise do material, emergiram três categorias: Assédio moral, conceito e características na visão dos profissionais de enfermagem; Comportamentos de assédio moral experimentados por profissionais de enfermagem; e Consequências do assédio moral. Conclui-se que o assédio moral é disseminado entre enfermeiros e técnicos de enfermagem, apesar de alguns profissionais discernirem o conceito dessa prática, sendo notória a prevalência do tipo descendente.

  18. The evolution of the DLK1-DIO3 imprinted domain in mammals.

    Directory of Open Access Journals (Sweden)

    Carol A Edwards

    2008-06-01

    Full Text Available A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.

  19. O suicídio assistido e o exercício da enfermagem

    Directory of Open Access Journals (Sweden)

    Renata Rabello de Oliveira

    2008-01-01

    Full Text Available Este artigo traz como tema central a discussão da prática do suicídio assistido. É um tema relativamente recente, porém, complexo e controverso. O suicídio assistido ocorre quando uma pessoa, que não consegue realizar sozinha sua intenção de morrer, solicita auxílio de uma outra pessoa para concretizá-lo. Esta prática vem senda aceita por alguns países e realizada por alguns profissionais em clínicas especializadas. O direito de decidir sobre o fim da vida e o valor que é atribuído ao sofrimento vivido são os principais questionamentos relativos a este tema. Paralelo a esta discussão, faz-se uma reflexão sobre a atuação do profissional enfermeiro nesta prática. Hoje, o profissional convive com este problema ético trazendo grande conflito com seus valores morais pessoais.

  20. Rabia en Potos flavus identificados en el departamento de madre de dios, Perú

    Directory of Open Access Journals (Sweden)

    Elena Vargas-Linares

    Full Text Available El Potos flavus es un mamífero nocturno que habita en bosques neotropicales desde Centroamérica hasta Sudamérica. Se realizó un estudio de cuatro casos de rabia en Potos flavus ocurridos desde abril de 2012 en el departamento de Madre de Dios en Perú, captados como parte de la vigilancia epidemiológica. Los análisis realizados en el laboratorio de referencia regional de Madre de Dios determinaron presencia de antígeno del virus de la rabia en tres de las muestras de tejido encefálico, dichos resultados fueron corroborados en el Laboratorio de Zoonosis Virales del Instituto Nacional de Salud del Perú mediante inmunofluorescencia directa, la tipificación no identificó ninguna de las variantes conocidas en murciélagos o en perros. La ocurrencia de cuatro casos de rabia en Potos flavus suma evidencias de la emergencia de un nuevo reservorio del virus de la rabia y que ha sido reportada previamente en el mismo departamento el año 2007

  1. Homicídios conjugais: notícias publicadas em jornais do sudeste do Brasil

    Directory of Open Access Journals (Sweden)

    Lucienne Martins Borges

    2016-12-01

    Full Text Available O homicídio conjugal consiste num gesto letal, ocorrido numa relação de intimidade, onde os envolvidos estão ou estiveram vinculados por um namoro, união estável ou casamento. O presente estudo objetivou realizar um mapeamento inicial dos homicídios conjugais por meio de uma pesquisa documental. Para tal, foram consultadas as matérias publicadas nos jornais O Estado de São Paulo e Jornal da Tarde entre 2000 e 2010. Os resultados vão ao encontro da literatura sobre o tema, o que possibilita elencar algumas características comuns a este tipo de gesto, como: prevalência de perpetradores homens; motivações distintas entre homens e mulheres para cometer o ato; maior ocorrência na residência de ambos ou de um dos envolvidos; diferença de idade; recorrente utilização de armas de fogo e armas brancas; existência de indícios precursores, com ênfase na violência conjugal. Os principais limites são tanto a falta de dados oficiais como a escassez da comunicação entre os órgãos que se ocupam do tema no Brasil.

  2. Assédio moral X clima organizacional: impacto na produtividade organizacional

    Directory of Open Access Journals (Sweden)

    Ana Maria Oliveira do Nascimento

    2012-07-01

    Full Text Available Este artigo visa abordar o problema do assédio moral nas empresas, um tema que ao longo do tempo vem ocupando lugar de destaque nas organizações. A vulnerabilidade e passividade do colaborador diante do agressor demonstra o lado oculto deste comportamento que é observado no dia-a-dia das organizações, esse artigo tem como objetivo demonstrar porque em muitos casos o colaborador submete-se ao assédio moral e por que quem agride está sempre em posições superiores. A queda na produtividade e os problemas de saúde que surgem como conseqüências da submissão são apenas alguns dos fatores que podem desencadear. Sabemos que nessa era de globalização e constantes processos de mudanças, temos que ser mais ágeis, práticos e profissionais buscando sempre a excelência das organizações em que atuamos. Contudo é sabido também que a partir do momento em que a nossa integridade e dignidade não são respeitadas nem conservadas, devemos parar e reavaliar os conceitos e projetos. Destarte, poucas são as leis que podem nos proteger nesse momento, mas já se estuda muito a respeito para que esse mal atinja um número menor possível de pessoas.

  3. GESTÃO FINANCEIRA DOS MUNICÍPIOS BRASILEIROS DE PORTE MÉDIO

    Directory of Open Access Journals (Sweden)

    Ademir Clemente

    2012-04-01

    Full Text Available O objetivo do presente artigo é mensurar e avaliar os fatores que determinam o espaço de manobra da gestão financeira dos municípios brasileiros de porte médio. A fundamentação teórica compreende a organização do setor público brasileiro, administração pública e a gestão financeira municipal. A pesquisa é descritiva e explicativa quanto aos objetivos; bibliográfica e documental quanto aos procedimentos; e quantitativa quanto à abordagem do problema, empregando regressão linear múltipla. São analisados os municípios brasileiros com população entre 100 mil e 1 milhão de habitantes, que disponibilizaram informações junto à base Finanças do Brasil (FINBRA/STN. Nas análises de regressão foram incluídas 22 variáveis explicativas, envolvendo aspectos financeiros e de gestão dos municípios. Conclui-se que, o espaço de gerenciamento financeiro à disposição dos administradores, nos municípios brasileiros de porte médio, depende basicamente das despesas com pessoal e do volume de receitas relacionadas com o crescimento do endividamento público.

  4. [Active search for leprosy and other skin diseases in school children from Agua de Dios, Colombia].

    Science.gov (United States)

    Rodríguez, Gerzaín; González, Rosalba; Gonzalez, Deysy; Granados, Carolina; Pinto, Rafael; Herrera, Hilda; Gutiérrez, Luisa F; Hernández, Elkin; López, Fernando; Gómez, Yenny

    2007-01-01

    Actively searching for leprosy, other skin diseases and BCG vaccination scars amongst school children from Agua de Dios, the municipality having the highest prevalence of leprosy in Colombia. A clinical examination of the children was carried out by nurses, interns, general practitioners and experts on leprosy. Skin smear tests and skin biopsies were performed when the clinical findings suggested leprosy. Anti-phenolic glycolipid antibodies in blood were determined in special cases. 86 % of the 2 844 school children were examined; 833 had skin diseases and 16 % of these required evaluation by specialists. Four new cases of paucibacillary leprosy, two indeterminate and two primary polyneuritic cases were found. Pediculosis capitis, pityriasis alba, tinea versicolor, hypopigmented nevus, insect bites and miliaria were frequently detected. BCG vaccination scars were absent in 387 children; following several logistical problems, they were vaccinated. Four children had signs of childhood abuse. An 11-year-old girl presented hypopigmented mycosis fungoides. All diseases and conditions found were treated. The community received information regarding the results, emphasising the importance of an early diagnosis of leprosy. The incidence of leprosy found (16/10,000) was 123 times higher than the rest of the country's incidence. It is advisable to continue clinical examinations in Agua de Dios and research into risk factors for acquiring leprosy.

  5. A PRIVATIZAÇÃO DOS PRESÍDIOS NO BRASIL

    Directory of Open Access Journals (Sweden)

    Nicoli Caroline Araujo Pinto

    2017-01-01

    Full Text Available O presente artigo propõe uma discussão sobre a questão da privatização dos presídios no Brasil, abordando sua aplicabilidade e discussão ao longo dos anos, bem como discute se o modelo de privatização seria uma solução para o atual modelo do sistema penitenciário. O objetivo deste estudo é buscar identificar se os parâmetros para determinar a privatização dos presídios brasileiros são ou não uma resposta aos problemas que o sistema penitenciário enfrenta no seu dia a dia. A metodologia adotada consistiu em análise bibliográfica relacionada à temática. Os resultados da pesquisa demonstraram que é necessário um aprofundamento na questão de privatização, devendo-se analisar se é um sistema funcional capaz de melhorar o já existente. Verificou-se que a proposta de privatização apresenta uma estratégia para melhorar a qualidade de vida dos detentos, por outro lado temos o interesse da empresa privada em aderir o sistema, buscando a obtenção de lucros ao transformar o preso em matéria-prima, tornando a ressocialização em segundo plano.

  6. A Politecnia nos Discursos Coletivos dos Professores do Ensino Médio Politécnico

    Directory of Open Access Journals (Sweden)

    Maria de Fatima Baldez Rodrigues

    2017-12-01

    Full Text Available Este trabalho discute a compreensão de politecnia no discurso coletivo de um grupo de 52 professores do 1º ano de 13 escolas do Ensino Médio Politécnico, de um município do Estado Rio Grande do Sul. No segundo semestre de 2016 e primeiro de 2017, foi realizada uma entrevista com um professor de cada área do conhecimento. O material discursivo foi analisado com a técnica do Discurso do Sujeito Coletivo – DSC. No discurso sobre a compreensão de politecnia, os professores apresentam questionamentos que evidenciam uma não apropriação desse conceito, delegando à equipe diretiva a responsabilidade por explicar o mesmo. Associam a politecnia ao ensino de diversas técnicas que preparam para o mercado de trabalho ou a integração das áreas do conhecimento. O estudo aponta que as diferentes propostas de reestruturação curriculares implementadas, como a do Ensino Médio Politécnico (2012 e a Base Nacional Comum Curricular (2017 são capazes de gerar confusão entre culturas por trazerem à tona questionamentos sobre as ideias, tecnologias e organização social da escola e potencializar o surgimento de outras culturas de formação docente.

  7. Regulation and function of the CD3¿ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro

    DEFF Research Database (Denmark)

    Dietrich, J; Kastrup, J; Nielsen, B L

    1997-01-01

    /CD3gamma chimeras; and in vitro by binding CD3gamma peptides to clathrin-coated vesicle adaptor proteins (APs). We find that the CD3gamma D127xxxLL131/132 sequence represents one united motif for binding of both AP-1 and AP-2, and that this motif functions as an active sorting motif in monomeric CD4...... and for AP binding in vitro. Furthermore, we provide evidence indicating that phosphorylation of CD3gamma S126 in the context of the complete TCR induces a conformational change that exposes the DxxxLL sequence for AP binding. Exposure of the DxxxLL motif causes an increase in the TCR internalization rate...

  8. Results of the DIOS pilot plant test and summary of the joint research; DIOS pilot plant no shiken sogyo kekka to kenkyu seika no matome

    Energy Technology Data Exchange (ETDEWEB)

    Sugiyama, T [Center for Coal Utilization, Japan, Tokyo (Japan); Kawaoka, K [The Japan Iron and Steel Federation, Tokyo (Japan)

    1996-09-01

    A joint research had been carried out with a subsidy from the Agency of Natural Resources and Energy since fiscal 1988 to fiscal 1995 on the direct iron ore smelting reduction process (DIOS process). The process utilizes coal directly as a process to use the strong points and supplement the weak points of the blast furnace process. During the period, a pilot plant had been operated since 1993. Upon having completed the feasibility study, this paper reports the result thereof. The main facilities consist of a smelting and reducing furnace of iron bath type, a spare reducing furnace of fluidized bed type, and a preheating furnace. The former two furnaces constitute a unit structure with the two furnaces connected vertically. The pilot plant achieved a three-day continuous operation producing 500 tons of iron every day. The production rate reached 21 tons an hour at an upward oxygen blowing velocity of about 13,000 Nm {sup 3} per hour. The coal unit requirement showed a result of <1000 kg/t for high VM coal and <900 kg/t for low VM coal. These results verified a possibility that this process can supplement or replace the blast furnace process even for a production scale of 9000 tons a day. 7 refs., 15 figs., 3 tabs.

  9. "Alguses oli tema üksinda, sest oli küll..." : [luuletused] / Kabir ; tlk. Doris Kareva

    Index Scriptorium Estoniae

    Kabir

    2006-01-01

    Sisu: "Alguses oli tema üksinda, sest oli küll..." ; "Kõik loodud on Kõiksuse poolt..." ; "Otsid Sa mind?..." ; "Kabir oma meele puhtaks..." ; "Pole pühades järvedes midagi muud peale vee..." ; "Otsisin kelme ja kõveraid..." ; "Ütle, vend, mida küll teha..." ; "Mis kurja on teinud su juuksed..." ; "Ära tõuse, et minna õue vaatama lilli..." ; "Sinu sünd inimesena on küps vili..." ; "Öö saatsid sa magades mööda..." ; "Pole ma hindu..." ; "Ma vaatan sind..." ; "Veskikivisid vaadeldes ; "Nähes aednikku lähenemas, õhkasid pungad..." ; "Tasa, tasa tõtta, mu meel..." ; "Ära kurvasta..." ; "Imetlusväärne on teemant..." ; "Kuula, sõber, see keha on Tema lüüra..." ; "Nagu seemnes varjul on õli..." ; "Olgugi ookean leekides..." ; "Tilka, mis lahustub meres..." ; "Jõgi ja lained on üks..." ; "Kes sa oled ja kust oled tulnud?..." ; "Kaovad kuningad, kauneimad kuningannad..." ; "Rohkem kui midagi muud..." ; "Lihalik, surelik tantsib selle ees..." ; "Väike rubiin, mida igaüks ihkab..." ; "Mine heade juurde, kus Armastatugi elab..." ; "Eksitus sulgeb väravad..." ; "Keelilt vallandub helisid..." ; "Kõik algab lahusoleku valust..." ; "Ärka, sõber! Miks ikka veel magad?..." ; "Kuu on mu kehas, kuid ise ma seda ei näe..." ; "Miks oled nii kärsitu, süda?..." ; "Kellele kuulub see flööt..." ; "Kui raske on Külalist kohata!..." ; "Kandetool toodi minule järgi mu isakoju..." ; "Siia ilma sündides nutsid..." ; "Oh mu süda! Ei jõudnud sa tundma õppida..." ; "Õige kulunud on sinu rüü..." ; "Õhkõrn on see õhuke rüü..." ; "Lipp, mida keegi ei näe..." ; "Oh otsija, lihtne liit lähim on südamele..." ; "Õhtu varjud on sügavaks saanud..." ; "Kuis saakski katkeda armastus me kahe vahel..." ; "Luik, tahaksin, et mulle räägiksid kõik oma loo..." ; "Kuhu ihaled küll, minu süda?..." ; "Ei lakka Lõpmatu flöödiheli..." ; "Mida näed, seda pole...". Autori kohta eluloolisi andmeid lk. 11

  10. Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

    OpenAIRE

    Shih, Shen-Liang; Lin, Yin-Shiou; Lin, Shyr-Yi; Hou, Wen-Chi

    2015-01-01

    Background The metabolic syndrome (MS) is termed a cluster of multiple metabolic risk criteria which is positively correlated with cardiovascular disease and type 2 diabetes mellitus (DM). Yam dioscorins have been reported to exhibit biological activities, however, little is known their preventive effects on the MS. Therefore, a high-fat (HF) diet was used to induce Wistar rat obesity and then yam dioscorin (50?mg/kg, dio50) was intervened daily concurrent HF diet (HF diet?+?dio50) for five w...

  11. X-ray digital industrial radiography (DIR) for local liquid velocity (V{sub LL}) measurement in trickle bed reactors (TBRs): Validation of the technique

    Energy Technology Data Exchange (ETDEWEB)

    Mohd Salleh, Khairul Anuar, E-mail: kmfgf@mst.edu; Lee, Hyoung Koo [Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Fulton Hall, 310 W. 14th St., Rolla, Missouri 65409 (United States); Rahman, Mohd Fitri Abdul [Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 143 Schrenk Hall, 400 W. 11th St., Rolla, Missouri 65409 (United States); Al Dahhan, Muthanna H. [Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Fulton Hall, 310 W. 14th St., Rolla, Missouri 65409 (United States); Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 143 Schrenk Hall, 400 W. 11th St., Rolla, Missouri 65409 (United States)

    2014-06-15

    Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (V{sub LL}) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the V{sub LL} within TBRs.

  12. Biochemical and Phylogenetic Characterization of a Novel Diaminopimelate Biosynthesis Pathway in Prokaryotes Identifies a Diverged Form of ll-Diaminopimelate Aminotransferase▿ †

    OpenAIRE

    Hudson, André O.; Gilvarg, Charles; Leustek, Thomas

    2008-01-01

    A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an ll-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of l-2,3,4,5-tetrahydrodipicolinate to ll-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with o...

  13. X-ray digital industrial radiography (DIR) for local liquid velocity (V(LL)) measurement in trickle bed reactors (TBRs): validation of the technique.

    Science.gov (United States)

    Mohd Salleh, Khairul Anuar; Rahman, Mohd Fitri Abdul; Lee, Hyoung Koo; Al Dahhan, Muthanna H

    2014-06-01

    Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (V(LL)) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the V(LL) within TBRs.

  14. Akıllı Telefon Seçiminin Belirleyicileri: Üniversite Öğrencileri Üzerine Bir Uygulama

    Directory of Open Access Journals (Sweden)

    Halim TATLI

    2015-09-01

    Full Text Available Bu çalışmada, üniversite öğrencilerinin akıllı telefon seçimi üzerinde etkili olan faktörlerin tespit edilmesi amaçlanmıştır. Bu kapsamda, Bingöl Üniversitesinde okuyan öğrencilere uygulanan bir anketten elde edilen veriler kullanılmıştır. Bu anket, Ekim-Kasım 2014 tarihlerinde 400 öğrenciye uygulanmıştır. Öğrencilerin akıllı telefon seçimi cevap değişkeni, yaşın logaritması, aylık gelirin logaritması ve öğrencilerin akıllı telefona ilişkin bakış açılarının puanın logaritması açıklayıcı değişken olarak alınmıştır. Analizlerde lojistik regresyon kullanılmıştır. Tahmin edilen lojistik regresyon analizi sonucunda; öğrencilerin akıllı telefona ilişkin bakış açılarının puanın logaritması ve aylık gelirin logaritması anlamlı bir şekilde akıllı telefonu seçme olasılığını artırdığı tespit edilmiştir. Yaşın logaritması ile öğrencilerin akıllı telefon seçimi arasında anlamlı bir ilişki bulunamamıştır. Araştırmanın sonuçları, aylık gelir ve öğrencilerin akıllı telefona ilişkin bakış açıları, akıllı telefon seçiminin önemli belirleyicileri olduğunu göstermiştir.

  15. Performance of 2000CA/LL and 2260XL liquid scintillation spectrometers for low-level tritium and carbon-14 analyses

    International Nuclear Information System (INIS)

    Rozanski, K.; Stichler, W.; Schwarz, P.

    1991-01-01

    The performance of two commercially available liquid scintillation spectrometers for low-level counting of 3 H and 14 C has been investigated. Two models of new technology Tri-Carb spectrometers from the Packard Instrument Company were tested: the 2000CA/LL and 2260XL. The measurements revealed a superior 3 H performance of the 2000CA/LL equipment owing to its substantially higher counting efficiency. Results for 14 C are less conclusive and depend on the configuration of the counting parameters selected. A comparison of three commercially available scintillation cocktails for tritium assay in water samples revealed a superior performance for PicoFluor LLT. (Author)

  16. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults

    DEFF Research Database (Denmark)

    Dixon, Brian M; Barker, Tyler; McKinnon, Toni

    2012-01-01

    ABSTRACT: BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Significant levels of the protein hCAP18/LL-37 are found in the blood and may protect against...... = 0.63). CONCLUSIONS: We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37....

  17. Protein Profile and Plasmid Content of Lactococcus lactis subsp. lactis LL52 and Lactococcus lactis subsp. cremoris LC79 Strains under Several Stress Conditions

    OpenAIRE

    LALE, Rahmi; TÜKEL, Çağla; AKÇELİK, Mustafa

    2014-01-01

    Differences in the protein and plasmid content of 2 Lactococcus lactis strains, L. lactis subsp. lactis LL52 and L. lactis subsp. cremoris LC79, under the stresses of high and low temperature, osmotic shock, and low pH were determined. We identified 3 new proteins with molecular masses of 16.0, 29.4, and 45.0 kDa as high temperature stress response specific in strain LL52. High temperature stress did not cause any changes in the protein content of strain LC79. Proteins that were specific for ...

  18. Aspectos Teóricos, Conceituais e Jurídicos do Assédio Moral no Trabalho

    Directory of Open Access Journals (Sweden)

    Zilfran Ferreira de Araújo

    2015-06-01

    Full Text Available Este estudo tem por objetivo central compreender e analisar as interpretações doutrinárias e jurisprudenciais acerca do assédio moral no trabalho e as consequências que resultam desse comportamento, bem como acerca dos direitos da personalidade e do dano moral. Quanto à metodologia aplicada, esta obra tem natureza qualitativa, do tipo descritiva, com caráter bibliográfico e documental, sem inserção em campo. Como resultado, temos um diagnóstico da realidade do assédio moral nas relações de trabalho, trazendo consigo conceitos claros e relevantes quanto aos tipos de assédio existentes e a maneira de prevenção.

  19. Assédio moral no trabalho em universidade sob a perspectiva dos observadores da violência.

    Directory of Open Access Journals (Sweden)

    Thiago Soares Nunes

    2014-09-01

    Full Text Available O assédio moral no trabalho é uma violência que pode acarretar em danos à integridadefísica e psíquica da vítima, sua vida pessoal e o desempenho no trabalho. Além da vítima,observadores da violência, podem sofrer as consequências na medida em que visualizamas agressões. Portanto, verifica-se a relevância científica de identificar a ocorrência deassédio e seus desdobramentos sob a percepção de observadores da violência. A pesquisafoi classificada como descritiva, quali-quanti e estudo de caso. Evidenciou-se que 52,2% dospesquisados têm conhecimento de casos de assédio no setor e/ou na instituição em queestão vinculados.

  20. Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

    DEFF Research Database (Denmark)

    Hansen, Henrik H; Jensen, Majbrit M; Overgaard, Agnete

    2013-01-01

    is not clarified. Tesofensine effectively induces appetite suppression in the diet-induced obese (DIO) rat partially being ascribed to an indirect stimulation of central dopamine receptor function subsequent to blocked dopamine transporter activity. This is interesting, as obese patients have reduced central......Tesofensine is a triple monoamine reuptake inhibitor which inhibits noradrenaline, 5-HT and dopamine reuptake. Tesofensine is currently in clinical development for the treatment of obesity, however, the pharmacological basis for its strong and sustained effects in obesity management...... as compared to age-matched chow-fed rats. DIO rats also exhibited a marked reduction in baseline extracellular dopamine levels in the nucleus accumbens (NAcc) and prefrontal cortex (PFC), as compared to chow-fed rats using microdialysis. While acute administration of tesofensine (2.0mg/kg) normalized accumbal...

  1. Early Onset Inflammation in Pre-Insulin-Resistant Diet-Induced Obese Rats Does Not Affect the Vasoreactivity of Isolated Small Mesenteric Arteries

    DEFF Research Database (Denmark)

    Blædel, Martin; Raun, Kirsten; Boonen, Harrie C M

    2012-01-01

    Background: Obesity is an increasing burden affecting developed and emerging societies since it is associated with an increased risk of diabetes and consequent cardiovascular complications. Increasing evidence points towards a pivotal role of inflammation in the etiology of vascular dysfunction. ...... concomitant vascular dysfunction. The results show that inflammation and obesity are tightly associated, and that inflammation is manifested prior to significant insulin resistance and vascular dysfunction........ Our study aimed to investigate signs of inflammation and their relation to vascular dysfunction in rats receiving a high fat diet. Methods: Diet-induced obese (DIO) rats were used as a model since these rats exhibit a human pre-diabetic pathology. Oral glucose and insulin tolerance tests were...... conducted on DIO rats and their controls prior to the development of insulin resistance. Furthermore, the plasma contents of selected cytokines [macrophage chemoattractant protein (MCP-1), interleukin-6 (IL-6), and interleukin-1 (IL-1)] and the concentration of adiponectin were measured. Using wire...

  2. Rare Λb→Λ l+l- and Λb→Λ γ decays in the relativistic quark model

    Science.gov (United States)

    Faustov, R. N.; Galkin, V. O.

    2017-09-01

    Rare Λb→Λ l+l- and Λb→Λ γ decays are investigated in the relativistic quark model based on the quark-diquark picture of baryons. The decay form factors are calculated accounting for all relativistic effects, including relativistic transformations of baryon wave functions from rest to a moving reference frame and the contribution of the intermediate negative-energy states. The momentum-transfer-squared dependence of the form factors is explicitly determined in the whole accessible kinematical range. The calculated decay branching fractions, various forward-backward asymmetries for the rare decay Λb→Λ μ+μ-, are found to be consistent with recent detailed measurements by the LHCb Collaboration. Predictions for the Λb→Λ τ+τ- decay observables are given.

  3. Threshold resummation at N3LL accuracy and soft-virtual cross sections at N3LO

    International Nuclear Information System (INIS)

    Catani, Stefano; Cieri, Leandro; Florian, Daniel de; Ferrera, Giancarlo; Grazzini, Massimiliano

    2014-01-01

    We consider QCD radiative corrections to the production of colorless high-mass systems in hadron collisions. We show that the recent computation of the soft-virtual corrections to Higgs boson production at N 3 LO [1] together with the universality structure of soft-gluon emission can be exploited to extract the general expression of the hard-virtual coefficient that contributes to threshold resummation at N 3 LL accuracy. The hard-virtual coefficient is directly related to the process-dependent virtual amplitude through a universal (process-independent) factorization formula that we explicitly evaluate up to three-loop order. As an application, we present the explicit expression of the soft-virtual N 3 LO corrections for the production of an arbitrary colorless system. In the case of the Drell–Yan process, we confirm the recent result of Ref. [2

  4. Measurement of the ratio σ{tt}/σ{Z/γ{*}→ll} and precise extraction of the tt cross section.

    Science.gov (United States)

    Aaltonen, T; Adelman, J; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; d'Errico, M; Di Canto, A; di Giovanni, G P; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, T; Dube, S; Ebina, K; Elagin, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Hughes, R E; Hurwitz, M; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leone, S; Lewis, J D; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Lovas, L; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramanov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Santi, L; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Simonenko, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Suh, J S; Sukhanov, A; Suslov, I; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wolfe, H; Wright, T; Wu, X; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhang, X; Zheng, Y; Zucchelli, S

    2010-07-02

    We report a measurement of the ratio of the tt to Z/γ{*} production cross sections in sqrt[s]=1.96  TeV pp collisions using data corresponding to an integrated luminosity of up to 4.6  fb{-1}, collected by the CDF II detector. The tt cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/γ{*}→ll cross section predicted by the standard model, the extracted tt cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result σ{tt}=7.70±0.52  pb, for a top-quark mass of 172.5  GeV/c{2}.

  5. Threshold resummation at N3LL accuracy and soft-virtual cross sections at N3LO

    Directory of Open Access Journals (Sweden)

    Stefano Catani

    2014-11-01

    Full Text Available We consider QCD radiative corrections to the production of colorless high-mass systems in hadron collisions. We show that the recent computation of the soft-virtual corrections to Higgs boson production at N3LO [1] together with the universality structure of soft-gluon emission can be exploited to extract the general expression of the hard-virtual coefficient that contributes to threshold resummation at N3LL accuracy. The hard-virtual coefficient is directly related to the process-dependent virtual amplitude through a universal (process-independent factorization formula that we explicitly evaluate up to three-loop order. As an application, we present the explicit expression of the soft-virtual N3LO corrections for the production of an arbitrary colorless system. In the case of the Drell–Yan process, we confirm the recent result of Ref. [2].

  6. A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats

    DEFF Research Database (Denmark)

    Andreassen, Kim V; Feigh, Michael; Hjuler, Sara T

    2014-01-01

    -induced obese (DIO) and Zucker diabetic fatty (ZDF) rats. In vitro, KBP-042 demonstrated superior binding affinity and activation of amylin and calcitonin receptors, and ex vivo, KBP-042 exerted inhibitory action on stimulated insulin and glucagon release from isolated islets. In vivo, KBP-042 induced...... a superior and pronounced reduction in food intake in conjunction with a sustained pair-fed corrected weight loss in DIO rats. Concomitantly, KBP-042 improved glucose homeostasis and reduced hyperinsulinemia and hyperleptinemia in conjunction with enhanced insulin sensitivity. In ZDF rats, KBP-042 induced...... antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic α- and β-cells. These results could provide the basis for oral KBP-042 as a novel therapeutic agent in type 2 diabetes....

  7. Noninvasive fMRI investigation of interaural level difference processing in the rat auditory subcortex.

    Directory of Open Access Journals (Sweden)

    Condon Lau

    Full Text Available OBJECTIVE: Interaural level difference (ILD is the difference in sound pressure level (SPL between the two ears and is one of the key physical cues used by the auditory system in sound localization. Our current understanding of ILD encoding has come primarily from invasive studies of individual structures, which have implicated subcortical structures such as the cochlear nucleus (CN, superior olivary complex (SOC, lateral lemniscus (LL, and inferior colliculus (IC. Noninvasive brain imaging enables studying ILD processing in multiple structures simultaneously. METHODS: In this study, blood oxygenation level-dependent (BOLD functional magnetic resonance imaging (fMRI is used for the first time to measure changes in the hemodynamic responses in the adult Sprague-Dawley rat subcortex during binaural stimulation with different ILDs. RESULTS AND SIGNIFICANCE: Consistent responses are observed in the CN, SOC, LL, and IC in both hemispheres. Voxel-by-voxel analysis of the change of the response amplitude with ILD indicates statistically significant ILD dependence in dorsal LL, IC, and a region containing parts of the SOC and LL. For all three regions, the larger amplitude response is located in the hemisphere contralateral from the higher SPL stimulus. These findings are supported by region of interest analysis. fMRI shows that ILD dependence occurs in both hemispheres and multiple subcortical levels of the auditory system. This study is the first step towards future studies examining subcortical binaural processing and sound localization in animal models of hearing.

  8. The Stubenberg meteorite—An LL6 chondrite fragmental breccia recovered soon after precise prediction of the strewn field

    Science.gov (United States)

    Bischoff, Addi; Barrat, Jean-Alix; Bauer, Kerstin; Burkhardt, Christoph; Busemann, Henner; Ebert, Samuel; Gonsior, Michael; Hakenmüller, Janina; Haloda, Jakub; Harries, Dennis; Heinlein, Dieter; Hiesinger, Harald; Hochleitner, Rupert; Hoffmann, Viktor; Kaliwoda, Melanie; Laubenstein, Matthias; Maden, Colin; Meier, Matthias M. M.; Morlok, Andreas; Pack, Andreas; Ruf, Alexander; Schmitt-Kopplin, Philippe; SchöNbäChler, Maria; Steele, Robert C. J.; Spurný, Pavel; Wimmer, Karl

    2017-08-01

    On March 6, 2016 at 21:36:51 UT, extended areas of Upper Austria, Bavaria (Germany) and the southwestern part of the Czech Republic were illuminated by a very bright bolide. This bolide was recorded by instruments in the Czech part of the European Fireball Network and it enabled complex and precise description of this event including prediction of the impact area. So far six meteorites totaling 1473 g have been found in the predicted area. The first pieces were recovered on March 12, 2016 on a field close to the village of Stubenberg (Bavaria). Stubenberg is a weakly shocked (S3) fragmental breccia consisting of abundant highly recrystallized rock fragments embedded in a clastic matrix. The texture, the large grain size of plagioclase, and the homogeneous compositions of olivine (Fa31.4) and pyroxene (Fs25.4) clearly indicate that Stubenberg is an LL6 chondrite breccia. This is consistent with the data on O, Ti, and Cr isotopes. Stubenberg does not contain solar wind-implanted noble gases. Data on the bulk chemistry, IR spectroscopy, cosmogenic nuclides, and organic components also indicate similarities to other metamorphosed LL chondrites. Noble gas studies reveal that the meteorite has a cosmic ray exposure (CRE) age of 36 ± 3 Ma and that most of the cosmogenic gases were produced in a meteoroid with a radius of at least 35 cm. This is larger than the size of the meteoroid which entered the Earth's atmosphere, which is constrained to <20 cm from short-lived radionuclide data. In combination, this might suggest a complex exposure history for Stubenberg.

  9. Mutations in the Lactococcus lactis Ll.LtrB group II intron that retain mobility in vivo

    Directory of Open Access Journals (Sweden)

    D'Souza Lisa M

    2002-12-01

    Full Text Available Abstract Background Group II introns are mobile genetic elements that form conserved secondary and tertiary structures. In order to determine which of the conserved structural elements are required for mobility, a series of domain and sub-domain deletions were made in the Lactococcus lactis group II intron (Ll.LtrB and tested for mobility in a genetic assay. Point mutations in domains V and VI were also tested. Results The largest deletion that could be made without severely compromising mobility was 158 nucleotides in DIVb(1–2. This mutant had a mobility frequency comparable to the wild-type Ll.LtrB intron (ΔORF construct. Hence, all subsequent mutations were done in this mutant background. Deletion of DIIb reduced mobility to approximately 18% of wild-type, while another deletion in domain II (nts 404–459 was mobile to a minor extent. Only two deletions in DI and none in DIII were tolerated. Some mobility was also observed for a DIVa deletion mutant. Of the three point mutants at position G3 in DV, only G3A retained mobility. In DVI, deletion of the branch-point nucleotide abolished mobility, but the presence of any nucleotide at the branch-point position restored mobility to some extent. Conclusions The smallest intron capable of efficient retrohoming was 725 nucleotides, comprising the DIVb(1–2 and DII(iia,b deletions. The tertiary elements found to be nonessential for mobility were alpha, kappa and eta. In DV, only the G3A mutant was mobile. A branch-point residue is required for intron mobility.

  10. Diet-induced obesity, exogenous leptin-, and MADB106 tumor cell challenge affect tissue leukocyte distribution and serum levels of cytokines in F344 rats.

    Science.gov (United States)

    Behrendt, Patrick; Buchenauer, Tobias; Horn, Rüdiger; Brabant, Georg; Jacobs, Roland; Bode, Felix; Stephan, Michael; Nave, Heike

    2010-08-01

    The adipocyte-derived catabolic protein leptin alters cell-mediated immunity and cytokine crosstalk. This may provide new insights into the altered immune response, seen in obese individuals. Therefore, we determined the tissue distribution of immune cells in diet-induced obese (dio) and normal weight F344 rats challenged with MADB106 tumor cells or leptin. Immune cell distribution in blood (by FACS analysis) and tissues (NK cells in spleen and liver, immunohistologically) as well as pro-inflammatory cytokines (IL-6, TNF-α; by flow cytometry) were investigated in 28 normal weight and 28 dio rats (n = 4-6/group). Pro-inflammatory cytokines were increased 3-fold for IL-6 and 7-fold for TNF-α in obese animals. Higher numbers of blood monocytes and NK cells were found in obese as compared to normal weight animals. In dio rats challenged with leptin and MADB106 tumor cells, monocyte numbers were decreased as compared to the obese control animals. Immunohistochemistry revealed an altered NK cell distribution in a compartment-, treatment-, and bodyweight-specific manner. In conclusion, our data reveal a distinct distribution pattern of monocytes and NK cells in dio rats as compared to normal weight littermates and an additional modulatory effect of a leptin- and MADB106 tumor cell challenge.

  11. Diminished metabolic responses to centrally-administered apelin-13 in diet-induced obese rats fed a high-fat diet.

    Science.gov (United States)

    Clarke, K J; Whitaker, K W; Reyes, T M

    2009-02-01

    The central administration of apelin, a recently identified adipokine, has been shown to affect food and water intake. The present study investigated whether body weight could affect an animal's response to apelin. The effects of centrally-administered apelin-13 on food and water intake, activity and metabolic rate were investigated in adult male diet-induced obese (DIO) rats fed either a high fat (32%) or control diet. Rats were administered i.c.v. apelin-13, 15-30 min prior to lights out, and food and water intake, activity and metabolic rate were assessed. Intracerebroventricular administration of apelin-13 decreased food and water intake and respiratory exchange ratio in DIO rats on the control diet, but had no effect in DIO rats on the high-fat diet. In an effort to identify potential central mechanisms explaining the observed physiological responses, the mRNA level of the apelin receptor, APJ, was examined in the hypothalamus. A high-fat diet induced an up-regulation of the expression of the receptor. Apelin induced a down-regulation of the receptor, but only in the DIO animals on the high-fat diet. In conclusion, we have demonstrated a diminished central nervous system response to apelin that is coincident with obesity.

  12. Novo método para calcular o diâmetro médio de agregados de solos

    Directory of Open Access Journals (Sweden)

    Q. de JONG van LIER

    1997-12-01

    Full Text Available Ao calcular o diâmetro médio ponderado (DMP ou o diâmetro médio geométrico (DMG de uma amostra de solo, ponderam-se o diâmetro médio aritmético (no caso do DMP ou o logarítmico (no caso do DMG de cada classe pela massa de agregados nela retida. A média aritmética de cada classe, multiplicada pela massa de agregados retidos na respectiva classe, apenas é correta, quando ocorrer uma distribuição simétrica de massa de agregados dentro de cada classe, o que é muito pouco provável. O objetivo deste trabalho, desenvolvido no final de 1996 no Departamento de Solos da UFRGS, Porto Alegre, é propor um novo método para o cálculo do diâmetro médio dos agregados, presumindo ser a distribuição dentro de cada classe semelhante à distribuição dos agregados de toda a amostra. Essa proposta pressupõe ser o diâmetro médio da classe mais bem estimado por aquele diâmetro que divide os agregados contidos nela em duas partes de massa igual. Para isso foi apresentado um procedimento de cálculo, e o diâmetro médio assim encontrado foi denominado "diâmetro médio ajustado" (DMA. Para testar o método, utilizaram-se dados existentes de vários solos, condições de manejo do solo e rotações de culturas. Considerando os resultados, justifica-se a utilização do parâmetro DMA no lugar do DMP ou DMG, por representar mais corretamente o diâmetro médio dos agregados de uma amostra de solo.

  13. SN 2017dio: A Type-Ic Supernova Exploding in a Hydrogen-rich Circumstellar Medium

    Science.gov (United States)

    Kuncarayakti, Hanindyo; Maeda, Keiichi; Ashall, Christopher J.; Prentice, Simon J.; Mattila, Seppo; Kankare, Erkki; Fransson, Claes; Lundqvist, Peter; Pastorello, Andrea; Leloudas, Giorgos; Anderson, Joseph P.; Benetti, Stefano; Bersten, Melina C.; Cappellaro, Enrico; Cartier, Régis; Denneau, Larry; Della Valle, Massimo; Elias-Rosa, Nancy; Folatelli, Gastón; Fraser, Morgan; Galbany, Lluís; Gall, Christa; Gal-Yam, Avishay; Gutiérrez, Claudia P.; Hamanowicz, Aleksandra; Heinze, Ari; Inserra, Cosimo; Kangas, Tuomas; Mazzali, Paolo; Melandri, Andrea; Pignata, Giuliano; Rest, Armin; Reynolds, Thomas; Roy, Rupak; Smartt, Stephen J.; Smith, Ken W.; Sollerman, Jesper; Somero, Auni; Stalder, Brian; Stritzinger, Maximilian; Taddia, Francesco; Tomasella, Lina; Tonry, John; Weiland, Henry; Young, David R.

    2018-02-01

    SN 2017dio shows both spectral characteristics of a type-Ic supernova (SN) and signs of a hydrogen-rich circumstellar medium (CSM). Prominent, narrow emission lines of H and He are superposed on the continuum. Subsequent evolution revealed that the SN ejecta are interacting with the CSM. The initial SN Ic identification was confirmed by removing the CSM interaction component from the spectrum and comparing with known SNe Ic and, reversely, adding a CSM interaction component to the spectra of known SNe Ic and comparing them to SN 2017dio. Excellent agreement was obtained with both procedures, reinforcing the SN Ic classification. The light curve constrains the pre-interaction SN Ic peak absolute magnitude to be around {M}g=-17.6 mag. No evidence of significant extinction is found, ruling out a brighter luminosity required by an SN Ia classification. These pieces of evidence support the view that SN 2017dio is an SN Ic, and therefore the first firm case of an SN Ic with signatures of hydrogen-rich CSM in the early spectrum. The CSM is unlikely to have been shaped by steady-state stellar winds. The mass loss of the progenitor star must have been intense, \\dot{M}∼ 0.02{({ε }{{H}α }/0.01)}-1 ({v}{wind}/500 km s‑1) ({v}{shock}/10,000 km s‑1)‑3 M ⊙ yr‑1, peaking at a few decades before the SN. Such a high mass-loss rate might have been experienced by the progenitor through eruptions or binary stripping. Based on observations made with the NOT, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. This work is based (in part) on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile as part of PESSTO, (the Public ESO Spectroscopic Survey for Transient Objects Survey) ESO program 188.D-3003, 191.D-0935, 197.D-1075. Based on observations made with the Liverpool Telescope operated on the

  14. Sobre o ódio ao professor Entrevista com Fernando Penna

    Directory of Open Access Journals (Sweden)

    Fernando Penna

    2016-01-01

    Full Text Available Ao tomar a decisão de pautar o tema da violência para compor o dossiê do terceiro número de Movimento – revista eletrônica de educação da Universidade Federal Fluminense –, o Conselho Editorial elencou um grande número de facetas da violência que historicamente se manifestam física e presencialmente no interior e fora do espaço escolar. O fenômeno relativamente recente das redes sociais e o vertiginoso processo de crescimento de trocas de informação, interação e mediação virtual a ele agregado, não apenas ampliou o espectro da violência como contribuiu decisivamente para articular o dentro e o fora da escola. Dentre outros exemplos, talvez o mais comum e antigo é o registro de cenas reais de alunos e alunas brigando nos pátios escolares ou nas redondezas da instituição postadas nas redes sociais, muitas delas viralizadas – para usar o barbarismoda ocasião – por um número sempre crescente de adeptos do bullying escolar. Nos últimos cinco anos, nas redes sociais, o exemplo de articulação da violência dentro-fora da escola que mais chama a atenção é o ódio ao professor, conforme observa o professor Fernando Penna na entrevista que publicamos a seguir. Estudioso da manifestação reivindicatória por uma escola sem ideologia trazida nos últimos anos por setores conservadores e reacionários da sociedade brasileira, Penna busca oferecer na entrevista algumas hipóteses para compreendermos o fenômeno do ódio ao professor, bem como algumas pistas para apreendermos os fundamentos que movem aqueles setores no combate ao que denominam de doutrinação ideológica de esquerda, e, concluindo, observa a urgência da resistência ao assédio moral feito dos conservadores ereacionários, chamando a atenção para a importância da ampliação do conhecimento crítico sobre o tema.

  15. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway

    Science.gov (United States)

    Vernia, Santiago; Cavanagh-Kyros, Julie; Barrett, Tamera; Jung, Dae Young; Kim, Jason K.; Davis, Roger J.

    2013-01-01

    The cJun N-terminal kinase (JNK) signaling pathway is a key mediator of metabolic stress responses caused by consuming a high-fat diet, including the development of obesity. To test the role of JNK, we examined diet-induced obesity in mice with targeted ablation of Jnk genes in the anterior pituitary gland. These mice exhibited an increase in the pituitary expression of thyroid-stimulating hormone (TSH), an increase in the blood concentration of thyroid hormone (T4), increased energy expenditure, and markedly reduced obesity compared with control mice. The increased amount of pituitary TSH was caused by reduced expression of type 2 iodothyronine deiodinase (Dio2), a gene that is required for T4-mediated negative feedback regulation of TSH expression. These data establish a molecular mechanism that accounts for the regulation of energy expenditure and the development of obesity by the JNK signaling pathway. PMID:24186979

  16. El simbolismo en Sólo Dios sabe, una película de Carlos Bolado

    OpenAIRE

    Aleksandra Jablonska

    2009-01-01

    Se realiza un análisis simbólico de la película Sólo Dios sabe de Carlos Bolado en los términos desarrollados, entre otros, por Eliade, Bachelard y Durand. Se observa que los símbolos no sólo aparecen en el contenido del filme -en que se relacionan sobre todo con el agua y con la lucha del Eros con Thánatos-, sino que son incorporados a su estructura narrativa, que toma la forma del viaje arquetípico del héroe. De este modo la película se inscribe dentro de la tendencia actual que cuestiona l...

  17. L'equazione di Dio Einstein, la relatività e l'universo in espansione

    CERN Document Server

    Aczel, Amir D

    2000-01-01

    Prendendo in esame le ultime scoperte della comunità scientifica mondiale, l'autore parla di cosmologia, ovvero lo studio della natura dell'universo. Servendosi di Einstein e delle sue teorie che spiegano i legami tra relatività e cosmologia, Aczel ci spiega come il grande scienziato si sia praticamente trasformato nel portavoce di Dio rivelandoci le verità fondamentali dell'universo in cui viviamo. In realtà lo studioso, quando nel 1912 dedusse dai suoi calcoli che l'universo era in continua espansione, ritenne implausibili le conclusioni della sua scoperta e inventò una costante matematica (la "costante cosmologica") che ovviasse al problema. Oggi la scienza conferma sempre più quell'ipotesi di novant'anni fa.

  18. Efeito do caseinato de sódio nas propriedades sensoriais do presunto "cook-in"

    OpenAIRE

    Udaeta,Jicela Elsa Morales; Terra,Nelcindo Nascimento

    1995-01-01

    Realizou-se o estudo do efeito das diferentes concentrações de caseinato de sódio nos atributos sensoriais do presento "cook-in". Em cada uma das quatro repetições, vinte presuntos foram designados ao acaso num dos cinco tratamentos, nos quais a formulação da salmoura de cura foi injetada a 20% em relação ao peso da carne em todos os tratamentos. A composição básica da salmoura correspondeu a 0,5% fosfato; 2,0% sal; 0,4% sais de cura; 0,66% condimento para presunto e 0,25% ascorbato, as condi...

  19. Subsídio e déficit habitacional no programa MCMV

    Directory of Open Access Journals (Sweden)

    José Eduardo Baravelli

    2015-07-01

    Full Text Available http://dx.doi.org/10.5007/2178-4582.2015v49n1p199 O artigo recupera documentos e pesquisas recentes sobre o programa Minha Casa Minha Vida para apontar o uso do conceito de déficit habitacional como legitimador político e institucional do programa de habitação do governo federal. Esta legitimação, por outro lado, esvazia de sentido político o subsídio habitacional para a provisão habitacional para famílias de baixa renda, ideal oriundo dos movimentos de moradia e que, uma vez transplantado para o centro do programa Minha Casa Minha Vida, se limita a dar suporte a uma política de desenvolvimento econômico da construção habitacional brasileira.

  20. Antropología y cuidados en el enfoque de San Juan de Dios

    Directory of Open Access Journals (Sweden)

    Genival Fernandes de Freitas

    Full Text Available El objetivo de esta investigación de carácter histórico-social, consiste en contribuir a la reflexión crítica sobre el origen y desarrollo de la cultura de los cuidados en el contexto socio-político y religioso del renacimiento español (siglo XVI desde la perspectiva de la orden mendicante de San Juan de Dios. La filosofía humanística o antropológica de la enfermería, en la perspectiva mencionada, implicaba potenciar la atención holística en el proceso de satisfacción de necesidades de los pacientes considerando el binomio hospitalidad-humanización de la asistencia.

  1. Padrões de relevo no médio rio Açungui-PR

    Directory of Open Access Journals (Sweden)

    Naldy Emerson CANALI

    1997-12-01

    Full Text Available O estudo e mapeamento dos padrões de relevo é uma ferramenta básica na caracterização físico-geográfica de uma área com a finalidade de orientar o seu zoneamento ambiental. O aproveitamento dos recursos hídricos da região Norte do Primeiro Planalto Paranaense deve ser precedido de estudos detalhados do meio ambiente, incluindo a geomorfologia. Com este objetivo o estudo dos padrões de relevo do médio curso do rio Açungui identificou um conjunto de sete padrões de relevo, revelando a complexidade da área, relacionada ao forte controle litológico-estrutural.

  2. Feminicídio: uma leitura a partir da perspectiva feminista

    OpenAIRE

    Sousa, Tania Teixeira Laky de

    2016-01-01

    Com este trabalho, pretendo formular um olhar sobre o fenômeno do feminicídio a partir das categorias de análise da diferença e hierarquia, entendidas no âmbito dos estudos feministas, tendo como motivação inicial o debate jurídico sobre a pertinência de legislação específica e sua efetividade na reversão das condições que motivam a violência contra as mulheres. The aim of this study is to formulate an approach on the femicide phenomenon from the analysis of the categories of difference an...

  3. Matricídio e transtorno bipolar Matricide and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Alexandre Martins Valença

    2009-01-01

    Full Text Available CONTEXTO: Matricídio é o assassinato de uma mãe pelo filho ou filha, uma forma de homicídio raramente vista na prática psiquiátrica. Estudos de casos de matricídio têm revelado a presença de transtornos mentais, tais como esquizofrenia, transtorno bipolar, transtornos de personalidade e alcoolismo, assim como casos em que não há evidência de transtorno mental. OBJETIVO: Tem-se como objetivo relatar o caso de uma mulher com transtorno bipolar que assassinou a sua genitora e que foi avaliada em perícia psiquiátrica para avaliação da responsabilidade penal. MÉTODOS: Foi realizada entrevista psiquiátrica, sendo o diagnóstico psiquiátrico estabelecido com base na entrevista e observação dos registros periciais e hospitalares, utilizando-se os critérios diagnósticos DSM-IV-TR. RESULTADOS: A examinanda foi considerada inimputável, em virtude da presença de doença mental que afetou inteiramente o seu entendimento e determinação em relação ao delito praticado. Ela cumpre medida de segurança em Hospital de Custódia e Tratamento Psiquiátrico há dois anos. CONCLUSÃO: É importante que psiquiatras e outros profissionais da saúde mental estejam atentos para risco de comportamento violento em pacientes que apresentam história de doença mental de longa duração, com episódios de violência durante a fase aguda, ameaças contra familiares ou amigos e falta de tratamento psiquiátrico regular.BACKGROUND: Matricide is the killing of one's own mother, and a type of homicide rarely seen on psychiatric practice. Matricide cases studies have shown the presence of mental disorders, such as schizophrenia, bipolar disorder, personality disorders and alcoholism, and have also found cases where there is no evidence of mental disorders. OBJECTIVE: We aim to report a case of a woman with bipolar disorder that murdered her own mother and had a psychiatric forensic evaluation to ascertain her penal imputability. METHODS: Psychiatric

  4. Suicídio de homens idosos no Brasil Suicide of elderly men in Brazil

    Directory of Open Access Journals (Sweden)

    Maria Cecília de Souza Minayo

    2012-10-01

    Full Text Available Discute-se o suicídio de homens idosos no Brasil. O texto se fundamenta em estudos de gênero e masculinidades e dá ênfase ao sentido de "masculinidade hegemônica" dentro da lógica do patriarcalismo que, no caso dos suicídios, se expressa na perda do trabalho como referência existencial e no sentido de honra como escudo. O estudo contempla casos de 40 homens que faleceram por suicídio no período entre 2006 a 2009 em dez municípios do país e tinham idade acima de 60 anos. Pela técnica de autópsia psicossocial foram coletados e analisados dados da história e modo de vida; avaliação dos antecedentes; impacto na família; letalidade do método; proximidade de fontes de apoio; tentativas anteriores; estado mental que antecedeu o ato; reações da família e da comunidade. Embora sejam vários os fatores que se associam à morte autoinfligida nesse grupo social, é inegável a importância da cultura masculina hegemônica na preeminência do número de suicídios de homens idosos em relação com as mulheres idosas. É fundamental dar atenção especial aos homens nos momentos de passagem da vida laboral para a aposentadoria, nas situações de perdas de familiares referenciais e quando são diagnosticados com enfermidades crônicas degenerativas que provoquem deficiências, perda de autonomia ou impotência sexual.This paper assesses the suicide of elderly men in Brazil. The text is based on studies of gender and masculinity and emphasizes the sense of "hegemonic masculinity" within the logic of patriarchalism that, in the case of suicide, is expressed in the loss of employment as an existential reference and as a loss of honor. The study includes 40 cases of men over 60 who committed suicide between 2007 and 2010 in ten districts of the country. Using the psychosocial autopsy technique, data were collected and analyzed from their history and lifestyle; evaluation of the background to the act; the impact on their families; lethality

  5. Ensaios de inovação no ensino médio

    Directory of Open Access Journals (Sweden)

    Eleny Mitrulis

    2002-07-01

    Full Text Available O objetivo deste trabalho é examinar alguns ensaios de inovação que vêm ocorrendo no ensino de nível médio e destacar elementos que possam contribuir para sua interpretação bem como para a formulação de políticas de apoio e de orientação às escolas. Em um primeiro momento, examinam-se a centralidade do ensino médio no conjunto das reformas educativas, o direcionamento destas reformas no contexto da mudança do papel do Estado e as questões relativas à formação geral e à formação profissional. A segunda parte deste ensaio é dedicada ao exame de alguns conceitos de reforma e de inovação e à descrição e análise de relatos de experiências e ensaios de inovação realizados por escolas de nível médio. São relatos apresentados por escolas públicas estaduais que participaram da primeira fase do Programa de Expansão e Melhoria do Ensino Médio da Secretaria de Estado da Educação de São Paulo¹, entre os anos 2000 e 2001. Os relatos apresentados, com exceção daqueles referentes à gestão da aplicação dos recursos financeiros distribuídos pelo programa, referem-se a ensaios de inovação realizados pelas escolas antes de sua vinculação a ele.This article aims to examine some of the experiences implemented at the mid level and to highlight elements that can contribute to their interpretation as well as the formulation of policies to support and guide the schools. First, the centrality of mid level education to the body of educational reforms is examined, the nature of these reforms in the context of the changing role of the State and issues referring to training in general and of professionals. The second part is dedicated to an examination of some concepts of reform and of innovation and a description and analysis of reports of experiences and trails of innovations realized by mid level schools. These are reports presented by state public schools which participated in the first phase of the Program to Improve

  6. Timoma do mediastino médio: relato de caso Middle mediastinal thymoma: case report

    Directory of Open Access Journals (Sweden)

    Elias Kallás

    2005-06-01

    Full Text Available Paciente do sexo feminino, 55 anos, branca, com sinais clínicos sugestivos de miastenia gravis há aproximadamente 3 meses. A prova terapêutica com neostigmina evidenciou melhora da disfagia e ptose palpebral. Na radiografia de tórax observou-se imagem ocupando o mediastino médio com projeção à direita. A tomografia computadorizada de tórax revelou a presença de massa no mediastino médio, sendo indicado o tratamento cirúrgico. Chamou nossa atenção a localização pouco usual, já que, preferencialmente, os timomas localizam-se no mediastino superior e anterior. A evolução pós-operatória foi boa, sem complicações.We report on a case of a 55-year-old female, patient, who presented with clinical signs suggestive of myasthenia gravis over a period of approximately 3 months. The therapeutic option using neostigmine gave an improvement of the dysphagia and palpebral ptosis. A chest radiograph image demonstrated a mass occupying the medium mediastinum with projection to the right. Computed tomography of the thorax revealed the presence of a mass in the medium mediastinum, and thus surgery was inicated. During the operation the was was observed in the medium mediastinum suggesting thymoma. What caught our attention was the unusual location of the tumor as normally thymomas are found in the upper and anterior mediastinum.

  7. A QUEIXA DE ASSÉDIO MORAL NO TRABALHO E A PSICOTERAPIA

    Directory of Open Access Journals (Sweden)

    Carla Júlia Segre Faiman

    2016-07-01

    Full Text Available As relações interpessoais em ambientes de trabalho podem ser complexas, permeadas de múltiplas significações. Por vezes, alguns trabalhadores podem chegar a ser submetidos a situações emocionalmente penosas ou mesmo humilhantes. Classificam-se como assédio moral as situações em que a violência emocional é deliberada e repetidamente provocada contra uma pessoa. Dada a importância que o trabalho tem para as pessoas, dificuldades experimentadas no seu âmbito podem ter importantes repercussões subjetivas. Há pessoas que buscam atendimento por distúrbios desencadeados por situações consideradas como assédio moral no trabalho. Neste artigo, discute-se a psicoterapia nestas situações, chamando à atenção o manejo clínico no que se refere às conjugações de aspectos do contexto social de trabalho, eventualmente violentos e injustos, e os aspectos da subjetividade característicos da constituição psíquica de cada um. Recorrendo a autores como Ferenczi, valoriza-se o reconhecimento do potencial traumatogênico de algumas situações do contexto em que o indivíduo se insere. Por outro lado, são apontados os riscos que a psicoterapia corre quando o entendimento do psicoterapeuta passa a ser pautado pela crítica social, comprometendo a especificidade da escuta clínica.

  8. Vasculites dos médios e grandes vasos Medium and large vessel vasculitis

    Directory of Open Access Journals (Sweden)

    Hebert Roberto Clivati Brandt

    2009-02-01

    Full Text Available As vasculites são constituídas por um grande grupo de síndromes caracterizadas por inflamação e necrose da parede dos vasos sangüíneos, resultando em estreitamento ou oclusão do lúmen. A distribuição dos vasos envolvidos varia consideravelmente e serve de base para a classificação das síndromes vasculíticas: grandes vasos (arterite de Takayasu, arterite temporal; pequenos e médios vasos (poliarterite nodosa, síndrome de Churg-Strauss, granulomatose de Wegener, vasculites nas doenças reumáticas; e pequenos vasos (vasculite de hipersensibilidade, púrpura de Henoch-Schonlein, poliangeíte microscópica, crioglobulinemia. Este artigo revisa as vasculites dos médios e grandes vasos e opções terapêuticas atuais; além de oferecer orientação sobre abordagem diagnóstica e tratamento dos pacientes com suspeita de vasculite cutânea.Vasculitis comprises a broad group of syndromes characterized by inflammation and necrosis on the walls of blood vessels, resulting in narrowing or occlusion of the lumen. The distribution of involved blood vessel varies considerably and serves as the basis for one classification of vasculitic syndromes: large vessels (Takayasu arteritis, giant cell arteritis; medium and small muscular arteries (polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, vasculitis in rheumatic diseases; and small vessels ("hypersensitivity" vasculitis, Henoch-Schonlein purpura, microscopic polyangiitis, cryoglobulinemia. This article reviews medium and large vessel vasculitis and current treatment options; it also presents a comprehensive approach to diagnosing and treating patients with suspected cutaneous vasculitis.

  9. A dinâmica dos homicídios no Nordeste e em Pernambuco

    Directory of Open Access Journals (Sweden)

    José Maria Nóbrega Júnior

    2010-10-01

    Full Text Available O objetivo deste artigo é analisar a dinâmica das mortes por homicídio no Nordeste, região mais violenta do país em termos desse tipo de crime. Indicadores de homicídios foram analisados para todos os estados nordestinos, com ênfase em Pernambuco. A análise dos números demonstra um crescimento das mortes violentas e intencionais na região pelo menos desde o início da década de 1990, com maior impacto nos últimos 10 anos, chegando a ultrapassar os números do Sudeste em 2006. Buscou-se tabular esses números por grupos como faixa etária, nível de escolaridade e por regiões de Pernambuco, revelando-se as diferentes dimensões dessa dinâmica. The aim of the article The dynamics of homicides in the Northeast and Pernambuco is to review the dynamics of deaths by homicide in the Northeast ofBrazil, the most violent region in the country in terms of this kind of crime. Murder rates were analysed for all the North-eastern states, with special focus on Pernambuco. The statistical analysis shows a growth in violent and intentional deaths in the region at least since the start of the 1990s, peaking in the last 10 years and surpassing the figures for the Southeast in 2006. Associations were then sought with groups like age group, level of schooling and by regions of Pernambuco, revealing the different dimensions of the dynamics.

  10. Effect of NaCrSi2O6 component on Lindsley's pyroxene thermometer: An evaluation based on strongly metamorphosed LL chondrites

    Science.gov (United States)

    Nakamuta, Y.; Urata, K.; Shibata, Y.; Kuwahara, Y.

    2017-03-01

    In Lindsley's thermometry, a revised sequence of calculation of components is proposed for clinopyroxene, in which kosmochlor component is added. Temperatures obtained for the components calculated by the revised method are about 50 °C lower than those obtained for the components calculated by the Lindsley's original method and agree well with temperatures obtained from orthopyroxenes. Ca-partitioning between clino- and orthopyroxenes is then thought to be equilibrated in types 5 to 7 ordinary chondrites. The temperatures for Tuxtuac (LL5), Dhurmsala (LL6), NWA 2092 (LL6/7), and Dho 011 (LL7) are 767-793°, 818-835°, 872-892°, and 917-936°C, respectively, suggesting that chondrites of higher petrographic types show higher equilibrium temperatures of pyroxenes. The regression equations which relate temperature and Wo and Fs contents in the temperature-contoured pyroxene quadrilateral of 1 atm of Lindsley (1983) are also determined by the least squares method. It is possible to reproduce temperatures with an error less than 20 °C (2SE) using the regression equations.

  11. Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL.

    Science.gov (United States)

    Cui, Yunxi; Koirala, Deepak; Kang, HyunJin; Dhakal, Soma; Yangyuoru, Philip; Hurley, Laurence H; Mao, Hanbin

    2014-05-01

    Minute difference in free energy change of unfolding among structures in an oligonucleotide sequence can lead to a complex population equilibrium, which is rather challenging for ensemble techniques to decipher. Herein, we introduce a new method, molecular population dynamics (MPD), to describe the intricate equilibrium among non-B deoxyribonucleic acid (DNA) structures. Using mechanical unfolding in laser tweezers, we identified six DNA species in a cytosine (C)-rich bcl-2 promoter sequence. Population patterns of these species with and without a small molecule (IMC-76 or IMC-48) or the transcription factor hnRNP LL are compared to reveal the MPD of different species. With a pattern recognition algorithm, we found that IMC-48 and hnRNP LL share 80% similarity in stabilizing i-motifs with 60 s incubation. In contrast, IMC-76 demonstrates an opposite behavior, preferring flexible DNA hairpins. With 120-180 s incubation, IMC-48 and hnRNP LL destabilize i-motifs, which has been previously proposed to activate bcl-2 transcriptions. These results provide strong support, from the population equilibrium perspective, that small molecules and hnRNP LL can modulate bcl-2 transcription through interaction with i-motifs. The excellent agreement with biochemical results firmly validates the MPD analyses, which, we expect, can be widely applicable to investigate complex equilibrium of biomacromolecules. © 2014 The Author(s). Published by Oxford University Press [on behalf of Nucleic Acids Research].

  12. Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein

    Czech Academy of Sciences Publication Activity Database

    Šilhavý, Jan; Zídek, Václav; Landa, Vladimír; Šimáková, Miroslava; Mlejnek, Petr; Oliyarnyk, O.; Malínská, H.; Kazdová, L.; Mancini, M.; Pravenec, Michal

    2015-01-01

    Roč. 64, č. 3 (2015), s. 295-301 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) LH11049; GA MŠk(CZ) LL1204; GA MZd(CZ) NT14325; GA ČR(CZ) GB14-36804G Institutional support: RVO:67985823 Keywords : rosuvastatin * kidney damage * CRP * transgenic * spontaneously hypertensive rat Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.643, year: 2015

  13. Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome

    Czech Academy of Sciences Publication Activity Database

    Pravenec, Michal; Kožich, V.; Krijt, J.; Sokolová, J.; Zídek, Václav; Landa, Vladimír; Mlejnek, Petr; Šilhavý, Jan; Šimáková, Miroslava; Škop, V.; Trnovská, J.; Kazdová, L.; Kajiya, T.; Wang, J. M.; Kurtz, T. W.

    2016-01-01

    Roč. 67, č. 2 (2016), s. 335-341 ISSN 0194-911X R&D Projects: GA ČR GA14-09283S; GA MŠk(CZ) LH12061; GA MŠk(CZ) LL1204 Institutional support: RVO:67985823 Keywords : blood pressure * cysteine * folate receptor 1 * metabolic syndrome X * rats * inbred SHR Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 6.857, year: 2016

  14. Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

    Czech Academy of Sciences Publication Activity Database

    Malínská, H.; Oliyarnyk, O.; Škop, V.; Šilhavý, Jan; Landa, Vladimír; Zídek, Václav; Mlejnek, Petr; Šimáková, Miroslava; Strnad, Hynek; Kazdová, L.; Pravenec, Michal

    2016-01-01

    Roč. 11, č. 3 (2016), e0150924 E-ISSN 1932-6203 R&D Projects: GA MŠk(CZ) LL1204; GA MZd(CZ) NT14325 Institutional support: RVO:67985823 ; RVO:68378050 Keywords : inflammation * spontaneously hypertensive rat * transgenic * C-reactive protein * dicarbonyl stress * metformin Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 2.806, year: 2016

  15. Testing the Q-DIO as an instrument to measure the documented quality of nursing diagnoses, interventions, and outcomes.

    NARCIS (Netherlands)

    Muller-Staub, M.; Lunney, M.; Lavin, M.A.; Needham, I.; Odenbreit, M.; Achterberg, T. van

    2008-01-01

    PURPOSE: To describe pilot testing of Quality of Diagnoses, Interventions and Outcomes (Q-DIO), an instrument to measure quality of nursing documentation. DESIGN: Instrument testing was performed using a random, stratified sample of 60 nursing documentations representing hospital nursing with and

  16. Feminicídios em Porto Alegre, Rio Grande do Sul, Brasil: iniquidades de gênero ao morrer

    Directory of Open Access Journals (Sweden)

    Stela Nazareth Meneghel

    2017-12-01

    Full Text Available Resumo: Feminicídios são assassinatos de mulheres decorrentes das desigualdades de gênero e representam a forma mais extrema da violência contra a mulher. O referencial teórico-metodológico utilizado neste estudo foi a teoria do patriarcado e a análise crítica do discurso. Foram analisados os discursos referentes ao relatório final de 64 inquéritos policiais categorizados como feminicídios, ocorridos na cidade de Porto Alegre, Rio Grande do Sul, Brasil, no período de 2006 a 2010. As vítimas eram majoritariamente mulheres pobres, jovens e moradoras de regiões de periferia, havendo uma frequência elevada de prostitutas e mulheres executadas pelo tráfico; mortes não consideradas feminicídios pelos operadores policiais. Muitos inquéritos foram arquivados devido à ausência de provas e outros não foram nem ao menos iniciados. Nos inquéritos, havia discursos que desqualificavam e culpavam as vítimas, embora alguns criticassem as desigualdades entre homens e mulheres e identificassem os efeitos letais do machismo. Inquéritos policiais são fontes importantes para estudar o feminicídio na sociedade, agregando grande quantidade de informações sobre vítimas, agressores e cenários dos crimes.

  17. Assédio moral: seus impactos para os trabalhadores assediados e para os empregadores no Brasil

    Directory of Open Access Journals (Sweden)

    Arthur Ramos do Nascimento

    2017-07-01

    Full Text Available O Assédio Moral vem ganhando destaque ao longo dos anos. Seus indícios já vêm desde os primórdios da humanidade e vem evoluindo ao longo do tempo. Com a Revolução Industrial, começou a se dissipar. Nos dias atuais sua prática apesar de não ser proibida por nenhuma lei federal, possui suas restrições como mostra o estudo que foi feito através do Código Civil, Consolidação das Leis Trabalhistas, Constituição Federal de 1988, e também o Código penal entre outros projetos de lei. O presente artigo demonstra que prática do Assédio Moral, acarreta impactos para as organizações que são, como, indenizações por danos morais, imagem da organização exposta na mídia, e problemas de saúde para a vítima entre outros. Possuindo uma pesquisa bibliográfica, o presente artigo abordará o tipo de assédio moral mais comum que é o Assédio Vertical Descendente, e formas de reparação dos danos causados por suas práticas as vítimas.

  18. Saúde mental do trabalhador: o assédio moral praticado contra trabalhadores com LER/DORT

    Directory of Open Access Journals (Sweden)

    Edil Ferreira da Silva

    Full Text Available Este artigo analisa como o assédio moral se configura na vida dos portadores de lesões por esforços repetitivos/distúrbios osteomusculares relacionados ao trabalho (LER/DORT. Participaram do estudo, realizado em 2007, 20 trabalhadores acometidos por LER/DORT de uma indústria do calçado em Campina Grande-PB. Empregaram-se entrevista semiestruturada e análise de conteúdo. Os resultados apresentam um quadro de assédio moral interpessoal e organizacional que está bem configurado nas histórias de adoecimento dos trabalhadores e nas suas trajetórias de busca de ajuda para seus problemas de saúde. O assédio moral interpessoal e organizacional se evidencia em virtude de todos os aspectos de humilhação, exclusão e pressão que recebem no ambiente de trabalho, sob forma de coação, subversão, chantagem e rebaixamento. Para não terem que sofrer com o desemprego, alguns preferem pedir demissão, outros suportam as dores, ultrapassando os limites do corpo. A lógica da produção de assédio moral e organizacional destrói a solidariedade e impede que os trabalhadores construam coletivamente formas de enfrentamento do trabalho.

  19. Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

    DEFF Research Database (Denmark)

    Grarup, Niels; Andersen, Mette K; Andreasen, Camilla H

    2007-01-01

    The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance....

  20. Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice

    Directory of Open Access Journals (Sweden)

    Janmey Paul A

    2009-09-01

    Full Text Available Abstract Background The worldwide appearance of drug-resistant strains of H. pylori motivates a search for new agents with therapeutic potential against this family of bacteria that colonizes the stomach, and is associated with adenocarcinoma development. This study was designed to assess in vitro the anti-H. pylori potential of cathelicidin LL-37 peptide, which is naturally present in gastric juice, its optimized synthetic analog WLBU2, and the non-peptide antibacterial agent ceragenin CSA-13. Results In agreement with previous studies, increased expression of hCAP-18/LL-37 was observed in gastric mucosa obtained from H. pylori infected subjects. MBC (minimum bactericidal concentration values determined in nutrient-containing media range from 100-800 μg/ml for LL-37, 17.8-142 μg/ml for WLBU2 and 0.275-8.9 μg/ml for ceragenin CSA-13. These data indicate substantial, but widely differing antibacterial activities against clinical isolates of H. pylori. After incubation in simulated gastric juice (low pH with presence of pepsin CSA-13, but not LL-37 or WLBU2, retained antibacterial activity. Compared to LL-37 and WLBU2 peptides, CSA-13 activity was also more resistant to inhibition by isolated host gastric mucins. Conclusion These data indicate that cholic acid-based antimicrobial agents such as CSA-13 resist proteolytic degradation and inhibition by mucin and have potential for treatment of H. pylori infections, including those caused by the clarithromycin and/or metronidazole-resistant strains.

  1. The L-L oligomerization domain resides at the very N-terminus of the sendai virus L RNA polymerase protein

    International Nuclear Information System (INIS)

    Cevik, Bayram; Smallwood, Sherin; Moyer, Sue A.

    2003-01-01

    The Sendai virus RNA-dependent RNA polymerase is composed of the L and P proteins. We previously showed that the L protein gives intragenic complementation and forms an oligomer where the L-L interaction site mapped to the N-terminal half of the protein (S. Smallwood et al., 2002, Virology, 00, 000-000). We now show that L oligomerization does not depend on P protein and progressively smaller N-terminal fragments of L from amino acids (aa) 1-1146 through aa 1-174 all bind wild-type L. C-terminal truncations up to aa 424, which bind L, can complement the transcription defect in an L mutant altered at aa 379, although these L truncation mutants do not bind P. The fragment of L comprising aa 1-895, furthermore, acts as a dominant-negative mutant to inhibit transcription of wild-type L. N-terminal deletions of aa 1-189 and aa 1-734 have lost the ability to form the L-L complex as well as the L-P complex, although they still bind C protein. These data are consistent with the L-L interaction site residing in aa 1-174. Site-directed mutations in the N-terminal 347 aa, of L which abolish P binding, do not affect L-L complex formation, so while the L and P binding sites on L are overlapping they are mediated by different amino acids. The N-terminal portions of L with aa 1-424, aa 1-381, and to a lesser extent aa 1-174, can complement the transcription defect in an L mutant altered at aa 77-81, showing their L-L interaction is functional

  2. ANÁLISE DE SÓDIO EM PREPARAÇÕES HABITUALMENTE CONSUMIDAS EM RESTAURANTES SELF SERVICE

    Directory of Open Access Journals (Sweden)

    Mônica Glória Neumann SPINELLI

    2011-01-01

    Full Text Available A demanda de refeições fora dos domicílios tem sido atendida, em grande parte, por restaurantes do tipo self service. Estes, apesar de atenderem bem, não apresentam preocupações quanto às questões nutricionais, principalmente em relação ao sódio, proporcionado por inúmeros condimentos e pelo sal, que tornam a refeição mais saborosa. Este estudo objetivou analisar os valores de sódio nas preparações de arroz, feijão e carne oferecidas em 15 restaurantes comerciais tipo self service no município de Mogi das Cruzes – SP. Para a determinação de sódio foi utilizado o método de fotometria de chama através da emissão atômica. A amplitude de variação de sódio presente em 100g de arroz branco foi de 75mg a 487mg, com média de 121,6(106,7 mg; no feijão carioca a variação foi de 96mg a 543mg, com média de 346,6(124,5mg, ao passo que, na carne, foi de 258mg a 1114mg, apresentando média de 552,6(238,3mg. A média da quantidade de sódio presente, utilizando-se o porcionamento do Guia Alimentar, excedeu em 25% a quantidade máxima de sódio recomendada para uma única refeição apenas com os três alimentos estudados. Nos locais avaliados, os cardápios mostraram concentrações elevadas de sódio na maior parte dos alimentos, com grandes variações entre os restaurantes, evidenciando a necessidade de criação de receituário padrão para a área de restaurantes comerciais.

  3. Feminicídios: estudo em capitais e municípios brasileiros de grande porte populacional

    Directory of Open Access Journals (Sweden)

    Stela Nazareth Meneghel

    Full Text Available Resumo Este estudo objetiva analisar a relação entre feminicídios e indicadores socioeconômicos, demográficos, de acesso e saúde em capitais e municípios brasileiros de grande porte populacional. Trata-se de um estudo ecológico que utilizou o coeficiente médio padronizado da mortalidade feminina por agressão como marcador de feminicídio nos triênios de 2007-2009 e 2011-2013. Para a análise estatística foi utilizado o teste de Correlação de Pearson entre o desfecho e 17 variáveis independentes, e as que apresentaram significância estatística (p < 0,05 foram introduzidas em um modelo de regressão linear multivariada, método Backward. No primeiro triênio a taxa média de feminicídio foi de 4,5 óbitos por 100 mil mulheres, e no segundo período foi de 4,9/100 mil. Pobreza (β = -0,330; p = 0,006, pentecostalismo (β = 0,237; p = 0,002 e mortalidade masculina por agressão (β = 0,841; p = 0,000 estiveram associados aos feminicídios. A associação negativa entre pobreza e mortes femininas indica uma relação paradoxal, na medida em que as mulheres que morrem nas regiões mais ricas são pobres em sua maioria. Ainda, encontrou-se relação entre violência de gênero, fundamentalismos e violência urbana.

  4. Unstable Malaria Transmission in the Southern Peruvian Amazon and Its Association with Gold Mining, Madre de Dios, 2001–2012

    Science.gov (United States)

    Sanchez, Juan F.; Carnero, Andres M.; Rivera, Esteban; Rosales, Luis A.; Baldeviano, G. Christian; Asencios, Jorge L.; Edgel, Kimberly A.; Vinetz, Joseph M.; Lescano, Andres G.

    2017-01-01

    The reemergence of malaria in the last decade in Madre de Dios, southern Peruvian Amazon basin, was accompanied by ecological, political, and socioeconomic changes related to the proliferation of illegal gold mining. We conducted a secondary analysis of passive malaria surveillance data reported by the health networks in Madre de Dios between 2001 and 2012. We calculated the number of cases of malaria by year, geographic location, intensity of illegal mining activities, and proximity of health facilities to the Peru–Brazil Interoceanic Highway. During 2001–2012, 203,773 febrile cases were identified in Madre de Dios, of which 30,811 (15.1%) were confirmed cases of malaria; all but 10 cases were due to Plasmodium vivax. Cases of malaria rose rapidly between 2004 and 2007, reached 4,469 cases in 2005, and then declined after 2010 to pre-2004 levels. Health facilities located in areas of intense illegal gold mining reported 30-fold more cases than those in non-mining areas (ratio = 31.54, 95% confidence interval [CI] = 19.28, 51.60). Finally, health facilities located > 1 km from the Interoceanic Highway reported significantly more cases than health facilities within this distance (ratio = 16.20, 95% CI = 8.25, 31.80). Transmission of malaria in Madre de Dios is unstable, geographically heterogeneous, and strongly associated with illegal gold mining. These findings highlight the importance of spatially oriented interventions to control malaria in Madre de Dios, as well as the need for research on malaria transmission in illegal gold mining camps. PMID:27879461

  5. Uso de agrotóxicos e suicídios no Estado do Mato Grosso do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Recena Maria Celina Piazza

    2005-01-01

    Full Text Available As prevalências das tentativas de suicídio provocadas pela exposição a agrotóxicos de uso agrícola no Estado do Mato Grosso do Sul, Brasil, ocorridas entre janeiro 1992 a dezembro 2002, foram avaliadas baseadas nos registros das notificações de intoxicação do Centro Integrado de Vigilância Toxicológica da Secretaria de Saúde do Estado. Dados populacionais e de produção agrícola foram obtidos do Instituto Brasileiro de Geografia e Estatística, e dados de suicídio por causas diversas da Secretaria de Estado de Saúde. Foram registradas 1.355 notificações de intoxicação, sendo 506 tentativas de suicídio que levaram a 139 óbitos. As microrregiões de Campo Grande e Dourados apresentam as maiores prevalências de tentativas de suicídio. Alta prevalência de suicídios por causas diversas também foi observada em Dourados, com uma tendência de crescimento nos últimos dez anos. Os resultados deste estudo indicaram a microrregião de Dourados como uma das mais críticas do Estado do Mato Grosso do Sul com relação à ingestão voluntária de agrotóxicos, demonstrando a necessidade de um programa de vigilância epidemiológica para melhor investigar estes eventos na população rural da região.

  6. Uso de agrotóxicos e suicídios no Estado do Mato Grosso do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Dario Xavier Pires

    2005-04-01

    Full Text Available As prevalências das tentativas de suicídio provocadas pela exposição a agrotóxicos de uso agrícola no Estado do Mato Grosso do Sul, Brasil, ocorridas entre janeiro 1992 a dezembro 2002, foram avaliadas baseadas nos registros das notificações de intoxicação do Centro Integrado de Vigilância Toxicológica da Secretaria de Saúde do Estado. Dados populacionais e de produção agrícola foram obtidos do Instituto Brasileiro de Geografia e Estatística, e dados de suicídio por causas diversas da Secretaria de Estado de Saúde. Foram registradas 1.355 notificações de intoxicação, sendo 506 tentativas de suicídio que levaram a 139 óbitos. As microrregiões de Campo Grande e Dourados apresentam as maiores prevalências de tentativas de suicídio. Alta prevalência de suicídios por causas diversas também foi observada em Dourados, com uma tendência de crescimento nos últimos dez anos. Os resultados deste estudo indicaram a microrregião de Dourados como uma das mais críticas do Estado do Mato Grosso do Sul com relação à ingestão voluntária de agrotóxicos, demonstrando a necessidade de um programa de vigilância epidemiológica para melhor investigar estes eventos na população rural da região.

  7. Experiences of a gully survey in the Gödöllő Hillside Landscape Protection District, Hungary

    Science.gov (United States)

    Szabó, Boglárka; Bolf, Balázs; Szabó, Judit; Centeri, Csaba

    2016-04-01

    In the 1970s when Highway No. 3. was built in Hungary, environmental issues were not thoroughly considered. The main scope of our survey is the analyses of a gully created by the runoff from the highway and from the upper watershed. These excess waters were channeled into natural valleys alongside the highway. Five outlets were created where the runoff water developed deep gullies and deposited huge amount of sediment at the tail of the gullies. The surveyed gully can be found in central Hungary, at the border of Gödöllő city, which area belongs to the Gödöllő Hillside Landscape Protection District. The experimental area is situated 175-220 meters above the sea level and it is crossed by the M3 motorway which took part in the development of the surveyed linear erosion form. During our survey, several dams and channel modifications, buffer ditches were built from materials found mainly locally, in order to decrease the energy of waters, to hold up the runoff and this way to eliminate the erosion damage in this protected area. However it is difficult to install and to maintain the protective measures. Due to the nature protection status the possible use of the materials and methods are limited. We surveyed the longest gully, which is 320 meters long and its width is exceeding 3 meters at its head, close to the motorway. The average depth is 1 meter. In order to monitor the amount of the runoff we planted some rods, where the height aboveground was known. The survey was made with GPS (Global Position System- Trimble Juno SB ArcPad 8.0) where along the gully the GPS recorded the position in every 20 seconds. Besides we recorded every dams and every sudden changes, where the direction, slope angle, depth, width or other characteristic was different. The data processing and the maps was made in ArcMap10.2, QGIS 2.2 and in Google Earth. Furthermore, micro soil profiles were taken from the riverbed to know the thickness of the runoff after bigger rainfall events. The

  8. On Ensino da Astronomia no Ensino Médio sob Diferentes Abordagens Metodológicas

    Science.gov (United States)

    Voelzke, Marcos Rincon; Albrecht, Evonir

    2011-12-01

    O presente trabalho, sobre a intervenção de metodologias de ensino, foi desenvolvido na Escola Estadual Colônia dos Pescadores, na cidade de Caraguatatuba - SP, em três turmas do terceiro ano do Ensino Médio, perfazendo um total de 119 educandos, entre 16 e 19 anos. Antes de iniciar-se a intervenção, um questionário de vinte perguntas objetivas e dissertativas foi desenvolvido, aplicado pelo professor da classe, que ministrou as aulas correspondentes. Este questionário foi o mesmo em todas as três classes com o objetivo de diagnosticar o conhecimento prévio dos alunos sobre Astronomia. Começando a intervenção nas turmas, o professor envolvido usou três diferentes metodologias de ensino: (A) em forma de seminários, elaborados e apresentados pelos alunos, nos quais o professor fazia apenas as intervenções necessárias, (B) na forma tradicional, com a ajuda de multimídia para o desenvolvimento das aulas e a terceira (C) a tradicional, fazendo uso exclusivo de lousa e giz. No final do trabalho os alunos responderam o mesmo questionário novamente, de modo que os três métodos utilizados puderam ser comparados. Os resultados apresentados após a intervenção foram melhores que os resultados iniciais indicando a ocorrência de uma aprendizagem significativa. Quando os estudantes foram inicialmente questionados sobre quantos planetas existem no nosso sistema solar, a classe A obteve 39% de respostas certas, a classe B 48% e a classe C 46%, mas após o desenvolvimento das atividades, as classes obtiveram respectivamente 94%, 97 % e 90% de aproveitamento. No término do bimestre, foi sugerido aos educandos que elaborassem uma história em quadrinhos, a qual serviu para averiguar se os conceitos inicialmente observados foram alterados e se novos foram agregados. A análise das histórias foi dividida em três partes: Criatividade; Temas abordados; Emprego correto dos conceitos estudados. Ao final quatorze histórias foram confeccionadas. O aprendizado

  9. Mineralogia de solos com excesso de sódio no estado do Ceará

    Directory of Open Access Journals (Sweden)

    F. O. B. Mota

    1999-12-01

    Full Text Available Foram estudados dois perfis de solos com problemas de sodicidade (Planossolo Solódico e Solonetz-Solodizado, no estado do Ceará, com o objetivo de conhecer a mineralogia das frações areia, silte e argila e os processos de alterações que ocorrem nos respectivos minerais. A areia e o silte grosso foram avaliados por microscopia de polarização e contraste de fase, enquanto o silte fino e a argila foram analisados por difração de raios-X. Utilizou-se, ainda, a microscopia eletrônica de varredura para obtenção de informações complementares sobre as transformações mineralógicas ocorridas nos horizontes dos dois perfis. Verificou-se que o Planossolo Solódico apresenta na fração argila quantidades mais ou menos equivalentes de caulinita e montmorilonita no horizonte 2Btn, o mesmo acontecendo com as proporções de caulinita e vermiculita no horizonte A. Nas outras frações, foram encontrados teores variáveis de quartzo, plagioclásios, hornblenda e biotita. Por sua vez, o Solonetz-Solodizado mostrou uma fração argila essencialmente caulinítica ao longo de todo o perfil e com quantidades variáveis de quartzo, feldspato e biotita nas outras frações. Em ambos os perfis, o enriquecimento de argila no Bt resultou essencialmente das alterações "In situ" dos minerais primários intemperizáveis contidos na rocha subjacente. A hipótese de alternância de processos de oxi-redução nos horizontes A e, ou, E, em razão da baixa permeabilidade do horizonte 2Btn, provocando um processo de ferrólise naqueles horizontes, é também uma alternativa de gênese que não pode ser descartada para explicar o alto contraste textural desses solos. O intemperismo da albita e de outros plagioclásios ricos em sódio, o clima semi-árido, e a drenagem impedida são os fatores condicionantes dos percentuais elevados de sódio, observados nos dois pedons. Também nos dois solos, os teores destoantes de quartzo, a geomorfologia da região e a

  10. SINTESIS DE LA EVOLUCION HISTORICA DEL HOSPITAL SAN JUAN DE DIOS

    Directory of Open Access Journals (Sweden)

    Hernando Forero Caballero

    1985-12-01

    Full Text Available

    La evolución del hospital de San Juan de Dios, como entidad de carácter asistencial para la salud del pueblo colombiano, se puede dividir en 5 etapas, correspondientes al progreso médico, histórico y cultural del país. La primera etapa, fetal o "de crisálida" como la llamó el Profesor López de Mesa, se inició en 1564 con la organización de la colonia española en Santafé y consistió en el establecimiento de una casa con unas camas destinadas a atender a los españoles que padecían alguna enfermedad, por circunstancias climáticas o infectados de bacterias importadas por ellos mismos. La atención médica, si tal puede llamarse, la ofrecían los monjes que, por intuición o por poseer alguna cultura generala mística religiosa, eran las únicas personas con ciertas condiciones para proporcionar algún alivio a los enfermos.

    El hospital nació de la necesidad de proteger la salud de los conquistadores y sus familias y sobre todo del terror que les inspiraban las epidemias.

    La evolución del hospital de San Juan de Dios, como entidad de carácter asistencial para la salud del pueblo colombiano, se puede dividir en 5 etapas, correspondientes al progreso médico, histórico y cultural del país. La primera etapa, fetal o "de crisálida" como la llamó el Profesor López de Mesa, se inició en 1564 con la organización de la colonia española en Santafé y consistió en el establecimiento de una casa con unas camas destinadas a atender a los españoles que padecían alguna enfermedad, por circunstancias climáticas o infectados de bacterias importadas por ellos mismos. La atención médica, si tal puede llamarse, la ofrecían los monjes que, por intuición o por poseer alguna cultura genera la mística religiosa, eran las únicas personas con ciertas condiciones para proporcionar algún alivio a los enfermos. El hospital nació de la necesidad de proteger la salud de los conquistadores y sus familias y sobre todo del terror

  11. Diferentes metodologias aplicadas ao ensino de astronomia no Ensino Médio

    Science.gov (United States)

    Albrecht, E.; Voelzke, M. R.

    2009-03-01

    O presente trabalho de intervenção foi realizado junto à Escola Estadual Colònia dos Pescadores na cidade de Caraguatatuba, com très turmas do terceiro ano do Ensino Médio, envolvendo 119 alunos com idades entre 16 e 19 anos. A fase inicial foi composta de um questionário de vinte questíes dissertativas e objetivas, aplicado pelo professor titular da sala, que era o mesmo nas très turmas, para diagnosticar nos educandos os conceitos prévios sobre Astronomia e, partindo destes realizar um trabalho de intervenção nas classes envolvidas utilizando, em cada uma, metodologias diferentes: (A) sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervençíes necessárias; (B) de forma tradicional, com auxílio de multimídias para desenvolvimento das aulas e a terceira (C) tradicional, fazendo uso exclusivo de lousa e giz. Ao final do trabalho os alunos responderam novamente o questionário inicial para diagnosticar dentre as très metodologias utilizadas qual apresentou melhores aplicaçíes, os resultados iniciais foram comparados com os finais. Quando questionados a respeito do significado de Astronomia observou-se inicialmente que os acertos na turma A foram de 100%, turma B: 64%, turma C: 84%, após a intervenção os acertos foram: 100%, 97% e 85% respectivamente, demonstrando que houve um avanço significativo na turma B, a turma A manteve seu índice e a turma C evoluiu, porém não tanto quanto a B. Quando interrogados sobre quantos planetas vocè acha que existem em nosso Sistema Solar? os acertos foram: turma A: 39%, turma B: 48% e turma C: 46%, após o desenvolvimento do trabalho os acertos foram 94%, 97% e 90% respectivamente. Dentro das respostas obtidas observa-se que a metodologia tradicional com o auxílio de multimeios, aplicada na turma B, demonstrou melhores resultados, sendo a mais significativa. Outra conclusão muito importante é que apesar de o tema Astronomia ser amplamente

  12. The Bolivian Source Rocks. Sub Andean Zone. Madre de Dios. Chaco Les roches mères de Bolivie. Subandin. Madre de Dios. Chaco

    Directory of Open Access Journals (Sweden)

    Diaz Martinez E.

    2006-11-01

    Full Text Available A complete study of source-rock geochemical data has been carried out for the Bolivian foothills and foreland (Sub Andean Zone, Chaco and Madre de Dios in order to quantify the petroleum potential of the area. Overall available data have been compiled in a database, and a synthesis of the results is presented here. Besides the classical mid-Devonian source rocks (Tequeje Fm in the north, Limoncito Fm in the center and Los Monos Fm in the south, others may be just as important : theTomachi Fm (late Devonian in the north of the country and the Copacabana Fm. (late Carboniferous-early Permian in the northern Sub Andean Zone. Both present an excellent potential with S2 up to 40 mg HC/g and average values larger than 10 mg HC/g on few hundred meters. The latest Cretaceous (Flora Fm in the northern Sub Andean Zone also presents locally a high potential but has almost no influence, its thickness being quite reduced. Almost all the source rocks matured during the Neogene due to the subsidence in the Andean foreland and, locally, in the piggyback basins, and are thus involved in the current petroleum system. Silurian and Lower Paleozoic units also contain thick shale beds, but these source rocks were mature before the Jurassic in most of the country, except in the Chaco, the Boomerang and the central Sub Andean Zone, where the Silurian is not nowadays overmature and may play an important role. The different zones are compared based on their Source Potential Index (SPI which indicates that the richest areas are the northern Sub Andean Zone and the Madre de Dios basin with SPI greater than 10 t/m². Since these two areas remain almost unexplored and, at least for the northern Sub Andean zone, present very large structures, these results allow to be optimistic about the possibilities for future exploration. Une base de données géochimiques a été mise en place entre 1994 et 1995 à YPFB (Yacimientos Petrolíferos Fiscales Bolivianos afin de regrouper les

  13. [Light pollution increases morbidity and mortality rate from different causes in male rats].

    Science.gov (United States)

    Bukalev, A V; Vinogradova, I A; Zabezhinskiĭ, M A; Semenchenko, A V; Anisimov, V N

    2012-01-01

    The influence of different light regimes (constant light--LL; constant darkness--DD; standard light regime--LD, 12 hours light 12 hours darkness; natural lightening of the North-West of Russia--NL) on the dynamics of life's morbidity rate, spontaneous tumorigenesis and frequency of some kinds of non-tumor pathology revealed at the post-mortem examination of male rats was studied. It was found out that the maintenance of animals at LL and NL conditions led to the increase of the number of infectious diseases, substantially faster development of spontaneous tumors and the increase of non-tumor diseases in comparison with the animals kept at LD (standard light) regime. Light deprivation (DD) led to substantial reduction of development of new growth, of non-tumor and infectious diseases in comparison with the similar parameters in standard light regime.

  14. Deletion of genes involved in glutamate metabolism to improve poly-gamma-glutamic acid production in B. amyloliquefaciens LL3.

    Science.gov (United States)

    Zhang, Wei; He, Yulian; Gao, Weixia; Feng, Jun; Cao, Mingfeng; Yang, Chao; Song, Cunjiang; Wang, Shufang

    2015-02-01

    Here, we attempted to elevate poly-gamma-glutamic acid (γ-PGA) production by modifying genes involved in glutamate metabolism in Bacillus amyloliquefaciens LL3. Products of rocR, rocG and gudB facilitate the conversion from glutamate to 2-oxoglutarate in Bacillus subtillis. The gene odhA is responsible for the synthesis of a component of the 2-oxoglutarate dehydrogenase complex that catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl coenzyme A. In-frame deletions of these four genes were performed. In shake flask experiments the gudB/rocG double mutant presented enhanced production of γ-PGA, a 38 % increase compared with wild type. When fermented in a 5-L fermenter with pH control, the γ-PGA yield of the rocR mutant was increased to 5.83 g/L from 4.55 g/L for shake flask experiments. The gudB/rocG double mutant produced 5.68 g/L γ-PGA compared with that of 4.03 g/L for the wild type, a 40 % increase. Those results indicated the possibility of improving γ-PGA production by modifying glutamate metabolism, and identified potential genetic targets to improve γ-PGA production.

  15. A case of exemplarity: C. F. Rottböll's history of smallpox inoculation in Denmark-Norway, 1766.

    Science.gov (United States)

    Eriksen, Anne

    2010-01-01

    Smallpox inoculation was one of the great discoveries of the 18th century and has been written into the grand narrative of medical progress, describing the taming of epidemic disease. Setting the perspective of progress aside, the article explores how this medical innovation was situated in 18th-century society and culture. The aim is to investigate how medical practice was intertwined with social structure and cultural patterns. The article takes its case from a book published in Copenhagen in 1766 by Professor C. F. Rottböll, former Head Physician of the Royal Inoculation House in Copenhagen. Being the first medical treatise on inoculation in Denmark-Norway, the book also has a historical section followed by a collection of reports and letters written by a number of other authors from various parts of the kingdom. Through close reading, the article explores how the introduction of the new technique was described in the texts. The reports were written to present practice and discuss cases. In doing so, they also presented a variety of other concerns so that a diversity of aims and intentions are added to the medical ones. The social and rhetorical strategies employed illuminate social ambition and systems of patronage, as well as understandings of history and of truth.

  16. Raspberry Pi Kullanılarak bir Akıllı Ev Uygulaması Geliştirilmesi

    OpenAIRE

    YÜZGEÇ, Uğur; ABA, Ömer

    2018-01-01

    Bu çalışmada Raspberry Pi mikrodenetleyici tabanlı bir akıllı ev uygulaması gerçekleştirilmiştir. Çalışmakapsamında 64 Bit BCM2837 Chip, 1.2 GHz ARM Cortex A53 dört çekirdekli işlemci özelliklerine sahip RaspberryPi 3 mikrodenetleyici ile ultrasonik, hareket algılayıcı, sıcaklık/nem, titreşim modülü, servo motoru, buzzer (sesmodülü), kamera, ateş algılayıcı, DC motor, LDR, RGB led, tuş takımı, su tespit, RFID kit sensörleri kullanılmıştır.Uygulama kısmında çeşitli senaryo durumları için yapıl...

  17. Seismically-triggered organic-rich layers in recent sediments from Göllüköy Lake (North Anatolian Fault, Turkey)

    KAUST Repository

    Avsar, Ulas

    2014-09-29

    Multi-proxy analyses on the sedimentary sequence of Göllüköy Lake, which is located on the eastern North Anatolian Fault (NAF), reveals a complete and high-resolution paleoseismic record for the last 650 years. Six sedimentary events are detected in a 3.1 m-long piston core. They form distinct organic-rich intercalations within the background sedimentation, which are characterized by strong anomalies on the loss-on-ignition (LOI550) and total organic carbon (TOC) profiles, as well as by lighter colours on the X-ray radiographic images. Itrax micro-XRF core scanner data are also used to contribute to the detection and characterization of the event deposits. After the detection of the sedimentary events, their temporal correlation with the earthquakes in the historical seismicity catalogue of the NAF is tested. The youngest event is dated to 1940s by using 210Pb and 137Cs profiles in sediment, which coincides with the 1939 earthquake (Ms = 7.7) on the NAF. The ages of the older five events are determined based on radiocarbon dating and regional time–stratigraphic correlation. Radiocarbon dating on the bulk sediment samples does not provide reliable results due to hard-water effect. On the other hand, dating on charcoals, Ephippia of Daphnia and phragmite remains significantly improves the results and implies a mean sedimentation rate of 0.28 cm/yr. Based on this preliminary sedimentation rate, we show that organic matter content variations through our record correlate with the varve-based δ18O record of Nar Lake, which is located 350 km southwest of Göllüköy Lake. Accordingly, high-precipitation/low-evaporation climatic episodes detected in Nar Lake are represented by higher organic matter content in Göllüköy sediments. Fine-tuning the Göllüköy LOI550 record to the Nar δ18O record reveals that the ages of the sedimentary events in Göllüköy match with well-known historical earthquakes that occurred around the lake. Finally, the origin of the organic

  18. Seismically-triggered organic-rich layers in recent sediments from Göllüköy Lake (North Anatolian Fault, Turkey)

    KAUST Repository

    Avsar, Ulas; Hubert-Ferrari, Auré lia; De Batist, Marc; Lepoint, Gilles; Schmidt, Sabine; Fagel, Nathalie

    2014-01-01

    Multi-proxy analyses on the sedimentary sequence of Göllüköy Lake, which is located on the eastern North Anatolian Fault (NAF), reveals a complete and high-resolution paleoseismic record for the last 650 years. Six sedimentary events are detected in a 3.1 m-long piston core. They form distinct organic-rich intercalations within the background sedimentation, which are characterized by strong anomalies on the loss-on-ignition (LOI550) and total organic carbon (TOC) profiles, as well as by lighter colours on the X-ray radiographic images. Itrax micro-XRF core scanner data are also used to contribute to the detection and characterization of the event deposits. After the detection of the sedimentary events, their temporal correlation with the earthquakes in the historical seismicity catalogue of the NAF is tested. The youngest event is dated to 1940s by using 210Pb and 137Cs profiles in sediment, which coincides with the 1939 earthquake (Ms = 7.7) on the NAF. The ages of the older five events are determined based on radiocarbon dating and regional time–stratigraphic correlation. Radiocarbon dating on the bulk sediment samples does not provide reliable results due to hard-water effect. On the other hand, dating on charcoals, Ephippia of Daphnia and phragmite remains significantly improves the results and implies a mean sedimentation rate of 0.28 cm/yr. Based on this preliminary sedimentation rate, we show that organic matter content variations through our record correlate with the varve-based δ18O record of Nar Lake, which is located 350 km southwest of Göllüköy Lake. Accordingly, high-precipitation/low-evaporation climatic episodes detected in Nar Lake are represented by higher organic matter content in Göllüköy sediments. Fine-tuning the Göllüköy LOI550 record to the Nar δ18O record reveals that the ages of the sedimentary events in Göllüköy match with well-known historical earthquakes that occurred around the lake. Finally, the origin of the organic

  19. Indicadores de risco para tentativa de suicídio por envenenamento: um estudo caso-controle

    Directory of Open Access Journals (Sweden)

    Maria Cláudia da Cruz Pires

    2015-09-01

    Full Text Available RESUMO Objetivo Considerando o envenenamento como o método mais utilizado para a tentativa de suicídio e a escassez de evidências nacionais sobre o tema, investigamos alguns possíveis indicadores de risco nesse tipo de tentativa. Métodos Estudo do tipo caso-controle em uma emergência geral de um hospital público, na cidade do Recife com 220 indivíduos, distribuídos em dois grupos de 110 pacientes cada, que estavam em tratamento, sendo o grupo casos os sobreviventes de tentativa de suicídio por envenenamento e os controles, sem história de intoxicação/envenenamento nem tentativa de suicídio, pareados por gênero e idade. Resultados O gênero feminino predominou na amostra (70,9%, com idade média de 29 anos; 73% declararam etnia branca ou morena; menos da metade vivia em convívio marital; a maioria tinha religião; ambos tinham poucos anos de estudo. Houve diferença significativa (p = 0,003 para dependência financeira entre os grupos, com chance 2,25 vezes maior para tentar suicídio entre os casos. Ter sofrido fatos traumáticos e abuso sexual na infância revelou diferença significativa. Conclusões Foram considerados indicadores de risco no grupo caso: estar em dependência financeira de terceiros, ter sofrido abuso sexual na infância, ideação suicida, histórico de transtorno mental na família, possuir algum transtorno mental e, principalmente, comorbidade(s psiquiátrica(s. No modelo de regressão, foi possível estimar uma chance de tentativa de suicídio por envenenamento de até 94,0% na presença conjunta de quatro fatores. A pesquisa representa uma das primeiras iniciativas para ampliação das discussões sobre os fatores de risco para tentativa de suicídio em âmbito nacional.

  20. Mujer y teología: la cuestión de la imagen de Dios

    Directory of Open Access Journals (Sweden)

    Castilla de Cortázar, Blanca

    2016-04-01

    Full Text Available The question of the image of God, described in the book of Genesis, is a long-standing theological issue. Although there has been some progress in this regard in recent decades, particularly in relation to the theology of women, there is still work to be done. In this paper, after a brief iter on the progress on this matter, we take a closer look at Karol Wojtyla’s novel proposal in his magnum opus: The theology of the body, analyzing his method, starting points and main consequences. We conclude by pointing out the tasks ahead.La cuestión de la imagen de Dios, afirmada en el libro del Génesis, es un tema teológico con amplio recorrido, acerca del cual se ha avanzado en las últimas décadas, en relación con la teología de la mujer, tarea aún pendiente. En el presente trabajo, tras un breve iter en torno al progreso de esta cuestión, nos detendremos a analizar la novedosa propuesta de Karol Wojtyla en su obra magna: La teología del cuerpo, analizando su método, sus puntos de partida y sus principales consecuencias, para concluir señalando las tareas pendientes.

  1. Um Inimigo do Povo: o Livre-Pensador e o Suicídio

    Directory of Open Access Journals (Sweden)

    Ulisses Razzante Vaccari

    Full Text Available RESUMO: Partindo de uma leitura da peça Um inimigo do povo, de Ibsen, o presente texto procurará definir o livre-pensador como aquele que se opõe ao pensamento ou aos pensamentos dominantes, ousando pensar por si próprio. Ao fazê-lo, o livre-pensador se sacrifica, cometendo uma espécie de suicídio (material e moral, proveniente de seu amor incondicional pela sua comunidade. A partir da definição de Ibsen, o artigo procurará alguns exemplos na história do pensamento que a corroborem, como Sócrates, Galileu e Espinosa. No caso da arte, o texto tecerá algumas considerações acerca da transposição dessa condição do livre-pensador para o teatro, como acontece com o Galileu, de Brecht, e A morte de Empédocles, de Hölderlin. Ao final do texto, pretende-se mostrar que também Nietzsche possui uma concepção a respeito do livre-pensador, o qual deve se tornar atemporal e póstumo.

  2. La fisica dell'immortalità Dio, la cosmologia e la resurrezione dei morti

    CERN Document Server

    Tipler, Frank J

    1995-01-01

    “Questo libro descrive la teoria del Punto Omega: la teoria fisica e sperimentale di un Dio onnipresente onniscente e onnipotente, che in un giorno del futuro remoto farà risorgere ciascuno di noi alla vita eterna in una dimora che per ogni aspetto fondamentale è il paradiso della tradizione ebraico-cristiana. I singoli termini delle teoria – per esempio i concetti di onnipresenza, onniscienza, onnipotenza, corpo (spirituale) risuscitato, paradiso – saranno presentati come principi della fisica pura. In questo libro non farò mai appello alla rivelazione; mi appellerò, invece, ai risultati concreti della scienza moderna e alla ragione del lettore. Descriverò il meccanismo fisico della risurrezione universale. Mostrerò con estrema precisione come la fisica consenta la risurrezione alla vita eterna di tutti coloro che sono vissuti, che vivano o che vivranno. E mostrerò anche perché, nel futuro remoto, tale facoltà di risuscitare esisterà davvero e perché sarà effettivamente usata. A chi ha perd...

  3. ABORDAGEM DO BIOMA CERRADO EM LIVROS DIDÁTICOS DE BIOLOGIA DO ENSINO MÉDIO

    Directory of Open Access Journals (Sweden)

    Rafael Gonçalves Bezerra

    2013-03-01

    Full Text Available A educação brasileira tem os livros didáticos como principal recurso de informação a alunos e professores. Este trabalho analisa como ocorre a abordagem do bioma Cerrado em seis livros didáticos de biologia destinados ao Ensino Médio. Os aspectos analisados foram o número de páginas destinadas ao tema, figuras, exemplificações acerca da fauna e flora local e abordagem do tema. A análise mostrou que todos os aspectos são apresentados de maneira resumida. Exemplos da fauna e flora local, quando presente nos livros, são citados apenas com o nome popular. Como resultado, o bioma Cerrado é tratado de maneira acrítica quanto à sua situação de degradação e importância para a manutenção da biodiversidade mundial.

  4. Characterization and management of patients with retroperitoneal sarcoma, Hospital San Juan de Dios 2007-2012

    International Nuclear Information System (INIS)

    Batista Rodriguez, Gabriela

    2013-01-01

    Patients diagnosed with retroperitoneal sarcoma at the Hospital San Juan de Dios were characterized during the years 2007 to 2012. The population framework was taken from the hospital's Pathology service database. A total of 15 patients older than 12 years with a diagnosis of sarcoma or malignant fibrous histiocytoma and that the site of origin of the biopsy was the retroperitoneum were selected. The data of the selected patients were collected through a data collection form. The variables included were: age, sex, origin, dates of importance (income, discharge, surgery, complication), presence and type of complications, pathological staging, type of surgery, comorbidities, presence and date of recurrence, treatment with chemotherapy and radiotherapy, death and causes of death. A descriptive analysis with the calculation of frequency measurements (absolute and relative) was carried out to describe the occurrence of the event. The analysis of proportional risks was performed considering the relationship between death and time, the possible relationship with the service of approach, clinical stage and resection status was also assessed. Information on diagnosis, evaluation, staging and management of retroperitoneal sarcomas is cited in the theoretical framework [es

  5. Il bosone di Higgs l'invenzione e la scoperta della "particella di Dio"

    CERN Document Server

    Baggott, Jim

    2013-01-01

    Tra i tanti oggetti pervasivi ed elusivi che affollano la dimensione invisibile del mondo subatomico, il "bosone di Higgs" è stato il più pervasivo ed elusivo: quella particella era l'elemento cruciale che mancava a completare il puzzle del Modello Standard, perché conferiva massa a tutte le altre particelle elementari, un enigma rimasto altrimenti insoluto. Quando finalmente il 4 luglio 2012 il CERN ne ha annunciato la verifica sperimentale, la "particella di Dio" (come un fisico l'ha temerariamente denominata) ha attirato su di sé i riflettori dell'attenzione mediatica mondiale. Affrontando l'intera questione con un rigore che ne acuisce la densità intellettuale e la vertigine tecnologica, Jim Baggott segue due percorsi paralleli. Non solo, infatti, ne ricostruisce la genesi teorica, ma ripercorre tutte le stazioni di avvicinamento all'eclatante risultato di Ginevra: il legame tra i primi acceleratori degli anni Venti e le collisioni di particelle nei raggi cosmici; la messa a punto del ciclotrone da p...

  6. Os Episódios de Rita Patrício

    Directory of Open Access Journals (Sweden)

    Gustavo Rubim

    2014-12-01

    O texto propõe uma leitura do livro Episódios: da teorização estética em Fernando Pessoa, da au­toria de Rita Patrício. Datado de 2012, o livro só ficou realmente pronto e publicado em 2014. A leitura de­fende a originalidade deste exame minucioso dos textos de teoria estética e literária de Fernando Pessoa, tanto pela maneira como os trata autonomamente da obra poética e os estuda na sua escrita específica, quanto pelo efeito de deslocação dos tópicos habituais na análise do programa modernista português. A crí­tica do idealismo pessoano e da noção de obra enquanto totalidade or­gânica são sublinhados enquanto gestos condutores de toda a pesquisa. Propõem-se articulações com outros ensaios recentes que em Portugal procedem à revisão da crítica e da hermenêutica pes­soana.

  7. RETEXTUALIZAÇÕES MULTIMODAIS: Ensaios com Estudantes do Ensino Médio

    Directory of Open Access Journals (Sweden)

    Estefânia Cristina da Costa Mendes

    2018-03-01

    Full Text Available A produção de textos na escola sempre se caracterizou como uma atividade complexa, tendo em vista a demanda de se contemplar os usos sociais da linguagem e dos multiletramentos. Por conta dessa dificuldade, infelizmente, o que vemos é um ensino nada sistemático e progressivo da escrita, um ensino que não mobiliza as habilidades que envolvem a competência do escrever e não explora as diversas linguagens e semioses que estão à nossa disposição na contemporaneidade. O texto dissertativo-argumentativo cobrado pelo Enem, tão requisitado atualmente, reforça ainda mais um ensino pragmático e irreflexivo sobre o exercício da escrita. Tendo em vista esse contexto, o presente trabalho apresenta uma discussão e análises a respeito do procedimento de retextualização multimodal na tentativa de verificar como estudantes do Ensino Médio retextualizam um texto predominantemente verbal em textos multimodais. Por fim, constatamos a importância de levar para a sala de aula atividades que mobilizem outros tipos de linguagem para além do texto verbal e a possibilidade de mesclar essas atividades com as demandas exigidas pelos alunos, no caso, a redação do Enem.

  8. The effectiveness of contrasting protected areas in preventing deforestation in Madre de Dios, Peru.

    Science.gov (United States)

    Vuohelainen, Anni Johanna; Coad, Lauren; Marthews, Toby R; Malhi, Yadvinder; Killeen, Timothy J

    2012-10-01

    Accurate monitoring of the effectiveness of protected areas (PAs) in decreasing deforestation is increasingly important given the vital role of forest protection in climate change mitigation. Recent studies on PA effectiveness have used remote-sensing imagery to compare deforestation rates within PAs to surrounding areas. However, remote-sensing data used in isolation provides limited information on the factors contributing to effectiveness. We used landscape-modelling techniques to estimate the effectiveness of ten PAs in Madre de Dios, Peru. Factors influencing PA effectiveness were investigated using in situ key-informant interviews. Although all of the PAs studied had positive effectiveness scores, those with the highest scores were ecotourism and conservation concessions, where monitoring and surveillance activities and good relations with surrounding communities were reported as possible factors in decreasing deforestation rates. Native community areas had the lowest scores, with deforestation mainly driven by internal resource use and population growth. Weak local governance and immigration were identified as underlying factors decreasing the effectiveness of protection, whereas good relations with surrounding communities and monitoring activity increased effectiveness. The results highlight the need to combine remote sensing with in situ information on PA management because identification of drivers and deterrents of deforestation is vital for improving the effectiveness of protection.

  9. A PALAVRA É... GENOCÍDIO: A CONTINUIDADE DE PRÁTICAS RACISTAS NO BRASIL

    Directory of Open Access Journals (Sweden)

    Celso de Moraes Vergne

    2015-12-01

    Full Text Available ResumoAs práticas de extermínio no Brasil têm se dirigido a pobres, mas especialmente a negros pobres. A partir da análise da definição jurídica internacional de genocídio, empreendemos uma investigação acerca do que se produz como sentido sobre e para esta população, no cotidiano. Tomamos como estratégia metodológica a bricolagem, na busca de capturar o que escapa em atos do que o discurso racista busca negar. Nos diversos fragmentos apresentados, tomados de cenas comuns, compartilhadas na cultura e na história, podemos entender a lógica de desqualificação imposta aos negros, bem como uma lógica institucionalizada que aponta para esta população como sendo uma fonte potencial do mal, a ser controlada e eliminada. Além de tais práticas resultarem, de fato, em mortandade consentida de alguns, impõem um cotidiano que produz outros efeitos: diversas formas de morte em vida, seja pelo silenciamento, seja pela imposição de um lugar de desvalorização naturalizada.

  10. Práticas de leitura no ensino médio: o Pibid de Letras

    Directory of Open Access Journals (Sweden)

    Adair Aguiar Neitzel

    Full Text Available Analisa quais estratégias de leitura os licenciandos de Letras da Universidade do Vale do Itajaí (Univali desenvolveram no decorrer do Programa Institucional de Bolsa de Iniciação à Docência (Pibid, quais concepções dão sustentação a essas estratégias e como elas colaboram para a formação de leitores no ensino médio, em duas escolas da rede pública estadual de Santa Catarina, na cidade de Itajaí. O instrumento de coleta de dados foram os portfólios produzidos pelos licenciandos durante o desenvolvimento do projeto, postados no ambiente virtual da instituição executante, denominado Sophia. Foram analisadas cinco estratégias de leitura que se mostraram alinhadas com a concepção de literatura fruitiva, a qual concebe o texto como objeto a ser fruído, apreciado, preservando sua função estética.

  11. LETRAMENTOS LITERÁRIOS: O QUE SE AVALIA NO EXAME NACIONAL DO ENSINO MÉDIO?

    Directory of Open Access Journals (Sweden)

    Tatiana Simões e Luna

    2015-09-01

    Full Text Available Este trabalho analisa as questões da prova do Exame Nacional do Ensino Médio - ENEM 2013 relativas à literatura, verificando que conhecimentos literários estão sendo avaliados e exigidos do aluno no fim da educação básica. Interessa-nos refletir sobre o lugar ocupado pela literatura nessa avaliação, considerando que esta reflete e refrata o que vem sendo feito na educação brasileira nos últimos anos. Para tal, discutimos a didática ancorada na cronologia e a voltada para o letramento literário, com base principalmente nos estudos de Cereja (2005, Cosson (2009, Rouxel (2013 e nas OCNEM (BRASIL, 2006. Os resultados sinalizam alguns avanços, pois a prova recobre obras da literatura contemporânea, inclusive exemplos transgressores das convenções linguísticas, e propicia o diálogo com outras semioses. No entanto, a maioria das questões realiza uma abordagem inadequada do texto, tomando-o como pretexto para avaliar a compreensão textual ou o saber sobre conteúdos linguístico-estilísticos.

  12. CERN Library | Cecilia Jarlskog presents "Portrait of Gunnar Källén: a physics shooting star and poet of early quantum field theory" | 16 September

    CERN Multimedia

    2014-01-01

    Wolfgang Pauli referred to him as 'my discovery', Robert Oppenheimer described him as 'one of the most gifted theorists' and Niels Bohr found him enormously stimulating. Who was the man in question, Gunnar Källén (1926-1968)?   His appearance in the physics sky was like a shooting star. His contributions to the scientific debate caused excitement among young and old. Similar to his friend and mentor, Wolfgang Pauli, he demanded honesty and rigour in physics - a distinct dividing line between fact and speculation. In his obituary, Arthur S. Wightman would write: "Gunnar Källén was a proud continuer of the tradition in quantum field theory established by Wolfgang Pauli. His papers on quantum electrodynamics in the period 1950-1954 carried the non-perturbative approach to quantum electrodynamics forward to a point beyond which very little essential progress has been made up to the present day. At the time I was trying ...

  13. Angular dependence of Ll, L $\\alpha$ , L $\\beta$ and L $\\gamma$ X-ray differential and fluorescence cross-sections for Er, Ta, W, Au, Hg and Tl

    CERN Document Server

    Demir, L; Kurucu, Y; Karabulut, A; Sahin, Y; 10.1016/S0969-806X(02)00501-7

    2003-01-01

    Ll, L alpha , L beta and L gamma X-ray differential cross-sections, fluorescence cross-sections and L/sub i/-subshell ( sigma /sub L1/, sigma /sub L2/, and sigma /sub L3/) fluorescence cross-sections were measured for Er, Ta, W, Au, Hg, and Tl at an excitation energy of 59.6 keV using a Si(Li) detector. The differential cross-sections for these elements have been measured at different angles varying from 54 degrees to 153 degrees at intervals of 9 degrees . The Ll and L alpha groups in the L X-ray lines are found to be spatially anisotropic, while those in the L beta and L gamma peaks are isotropic. Experimental and theoretical values of L X-ray fluorescence cross- sections and L/sub i/-subshell X-ray fluorescence cross-sections were compared. (20 refs).

  14. [Effects of a short-term diet of precooked corn flour on the vaginal cycle, in rats placed in various conditions of environmental illumination].

    Science.gov (United States)

    Lopez de Onate, R; Giammanco, S; Carollo, F; Ernandes, M; Paderni, M A

    1989-03-01

    The aim of this research is to study the effects of a diet almost devoid of tryptophan, which is given by a feeding with precooked yellow corn meal (corn mush), on the alterations of the estrous cycle of animals in several conditions of environmental lighting. Indeed, it is known that cerebral serotonin influences the releasing of LH and consequently the ovulation. The different types of environmental lighting are: 1) Natural (alternating Day-Night = L/D). 2) Continuous dark (D/D). 3) Continuous light by sodium steams (L/L sodium). 4) Continuous light by fluorescent neon tubes (L/L neon). The muricide behaviour is studied by comparison rat-mouse. The feeding with precooked yellow corn meal (diet lacking of tryptophan) unchains in the 100% of the observations the CEA (Constant Estrous Anovulatory), and significantly shrinks the estral cycle in the female Wistar Rat in several conditions of environmental lighting.

  15. Assédio moral na relação de emprego e responsabilidade civil do empregador

    OpenAIRE

    Rondelli, Cristiane Montenegro

    2008-01-01

    Esta dissertação tem como objetivos conferir fundamentos para a defesa da responsabilidade objetiva do empregador em caso de assédio moral, apresentar propostas de atuação para prevenção do assédio moral no ambiente de trabalho e, principalmente, demonstrar a aplicação do princípio da dignidade humana nas relações interpessoais no ambiente de trabalho. O cuidado com o meio ambiente do trabalho envolve também aspectos psíquicos e não somente físicos. Tanto o meio ambiente adequado, como o próp...

  16. Genocídio: o Conselho de Segurança da ONU nos casos de Ruanda e Darfur

    OpenAIRE

    Alves, Thassio Soares Rocha [UNESP

    2016-01-01

    O presente estudo tem por objetivo a investigação da criação de dois instrumentos da Organização das Nações Unidas para a garantia dos Direitos Humanos, o Conselho de Segurança e a Convenção para a Prevenção e Repressão do Crime de Genocídio. Além disso, a principal linha de estudo é que os dois instrumentos supracitados não conseguiram evitar que casos de genocídio voltassem a ocorrer após o Holocausto, como nos casos do Camboja, Antiga Iugoslávia, Ruanda e Darfur, estes dois últimos o foco ...

  17. Successful Percutaneous Coronary Intervention through a Severely Bent Artificial Ascending Aorta Using the DIO Thrombus Aspiration Catheter

    Directory of Open Access Journals (Sweden)

    Akinori Fujikake

    2016-01-01

    Full Text Available A 66-year-old man was admitted to our institute because of chest pain. He had undergone replacement of the ascending aorta due to aortic dissection 9 years previously. We made a diagnosis of acute coronary syndrome, and coronary artery angiography was performed. Although the right coronary artery was successfully cannulated, a severe bend of the artificial aorta made it very difficult to advance the catheter into the left coronary artery. Ultimately, a DIO thrombus aspiration catheter was used to enter the left coronary artery, and a stent was implanted successfully. The DIO catheter is very useful when the selection of a guiding catheter is complicated, such as in the case of severe vessel tortuosity or a bend of the ascending aorta.

  18. A relação do público jovem com o rádio na atualidade

    Directory of Open Access Journals (Sweden)

    Rodrigo Lúcio Cardoso

    2011-08-01

    Full Text Available A relação do jovem com os meios de comunicação está se modificando principalmente devido à introdução das novas tecnologias na sociedade contemporânea. A fim de analisar a relação do público jovem com o rádio, foi aplicado um questionário em 349 sujeitos (jovens de 15 a 24 anos, das classes A e B, residentes em Porto Alegre, RS, no período de janeiro a maio de 2010. Dentre as principais conclusões, destacamos que o rádio se configura, na atualidade, como um “veículo de movimento”, ouvido principalmente no carro ou no celular/mp3 player.

  19. ASSÉDIO MORAL NAS RELAÇÕES DE TRABALHO: IMPLICAÇÕES PSICOLÓGICAS

    Directory of Open Access Journals (Sweden)

    Michele Gaboardi Lucas

    2016-01-01

    Full Text Available O assédio moral é caracterizado por condutas frias e repetitivas que têm por objetivo, desqualificar, humilhar e abalar psiquicamente um indivíduo. Com base nestes pressupostos, objetivou-se com o estudo, conhecer as consequências psicológicas causadas pelo assédio moral nas relações de trabalho. Tratou-se de uma pesquisa qualitativa exploratória, tendo como método de coleta de dados a entrevista semiestruturada que foi  analisada pelo método de análise de conteúdo. Os resultados revelaram que o fenômeno ocasiona vivências depressivas, alterações de humor, ansiedade generalizada, baixa autoestima e angústia constante. Acarretando em um desinteresse com práticas e hábitos, no cuidado da vida e do corpo.

  20. Physiological oxygen prevents frequent silencing of the DLK1-DIO3 cluster during human embryonic stem cells culture.

    Science.gov (United States)

    Xie, Pingyuan; Sun, Yi; Ouyang, Qi; Hu, Liang; Tan, Yueqiu; Zhou, Xiaoying; Xiong, Bo; Zhang, Qianjun; Yuan, Ding; Pan, Yi; Liu, Tiancheng; Liang, Ping; Lu, Guangxiu; Lin, Ge

    2014-02-01

    Genetic and epigenetic alterations are observed in long-term culture (>30 passages) of human embryonic stem cells (hESCs); however, little information is available in early cultures. Through a large-scale gene expression analysis between initial-passage hESCs (ihESCs, cell derivatives, possibly through attenuation of the expression and phosphorylation of p53. Furthermore, we demonstrated that 5% oxygen, instead of the commonly used 20% oxygen, is required for preserving the expression of the DLK1-DIO3 cluster. Overall, the data suggest that active expression of the DLK1-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs. © AlphaMed Press.

  1. Efeitos do ciclamato de sódio no rim fetal de ratos: estudo morfométrico.

    OpenAIRE

    Arruda, José Germano Ferraz de

    2004-01-01

    O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose, sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O objetivo deste estudo foi avaliar o efeito do ciclamato de sódio em rins de fetos de ratas, considerando-se alterações morfométricas do glomérulo, túbulo contornado proximal, túbulo contornado distal e ducto coletor. Foram utilizada...

  2. Queda dos homicídios em São Paulo, Brasil: uma análise descritiva

    Science.gov (United States)

    Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sérgio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sérgio

    2012-01-01

    Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (−74,5%), jovens de 15 a 24 anos (−78,0%) e moradores de áreas de exclusão social extrema (−79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (−74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

  3. Suicídio e o jogo da Baleia Azul analisados na perspectiva de Anomia de Émile Durkheim

    Directory of Open Access Journals (Sweden)

    Irineu Francisco Barreto Junior

    2017-06-01

    Full Text Available Este artigo apresenta uma síntese das principais ideias de Durkheim, representante da sociologia positivista. São revisitados os conceitos de fato social, solidariedade e anomia com o intuito de analisar os suicídios ocorridos no ano de 2017 e associados ao jogo da Baleia Azul, fenômeno mundial da internet e da Sociedade da Informação. O conceito de anomia pode ser compreendido como ausência de normas, que decorre de grande turbulência social, heteronomia, perda dos laços sociais e de solidariedade. Nessa perspectiva, o artigo problematiza a associação entre o conceito de suicídio anômico e as mortes associadas ao jogo da Baleia Azul.

  4. Signs and the design of life - Uexküll's significance today : a symposium, its significant history and future / Torsten Rüting

    Index Scriptorium Estoniae

    Rüting, Torsten

    2004-01-01

    2004. aastal tähistati mitut Jakob von Uexkülli tähtpäeva - 140. sünniaastapäeva, 60. surmaaastapäeva ja 70 aasta möödumist tema kuulsa teose "Jalutuskäik läbi loomade ja inimeste omailma" avaldamisest. Selle tähistamiseks korraldati Hamburgis sümpoosion "Signs and design of life - Uexküll`s significance today" (9.1.2004.a.)

  5. Efficacy of the Direct Instruction Language for Learning (DI-LL) Program to Promote Expressive and Receptive Language in Children with Autism Spectrum Disorder

    Science.gov (United States)

    2016-07-01

    Evaluator on PLP & CGI 1-3 Train staff on DOSL 1-3 Purchase child materials ( toys , stickers) 1-3 Purchase testing materials 1-3 Purchase DI-LL...been developed to address language delay including intensive treatment using applied behavior analysis (ABA). Although often effective for severe...to severe. Many interventions have been developed to address language delay including intensive treatment using applied behavior analysis (ABA

  6. Genetic mapping of the LOBED LEAF 1 (ClLL1) gene to a 127.6-kb region in watermelon (Citrullus lanatus L.).

    Science.gov (United States)

    Wei, Chunhua; Chen, Xiner; Wang, Zhongyuan; Liu, Qiyan; Li, Hao; Zhang, Yong; Ma, Jianxiang; Yang, Jianqiang; Zhang, Xian

    2017-01-01

    The lobed leaf character is a unique morphologic trait in crops, featuring many potential advantages for agricultural productivity. Although the majority of watermelon varieties feature lobed leaves, the genetic factors responsible for lobed leaf formation remain elusive. The F2:3 leaf shape segregating population offers the opportunity to study the underlying mechanism of lobed leaf formation in watermelon. Genetic analysis revealed that a single dominant allele (designated ClLL1) controlled the lobed leaf trait. A large-sized F3:4 population derived from F2:3 individuals was used to map ClLL1. A total of 5,966 reliable SNPs and indels were identified genome-wide via a combination of BSA and RNA-seq. Using the validated SNP and indel markers, the location of ClLL1 was narrowed down to a 127.6-kb region between markers W08314 and W07061, containing 23 putative ORFs. Expression analysis via qRT-PCR revealed differential expression patterns (fold-changes above 2-fold or below 0.5-fold) of three ORFs (ORF3, ORF11, and ORF18) between lobed and non-lobed leaf plants. Based on gene annotation and expression analysis, ORF18 (encoding an uncharacterized protein) and ORF22 (encoding a homeobox-leucine zipper-like protein) were considered as most likely candidate genes. Furthermore, sequence analysis revealed no polymorphisms in cDNA sequences of ORF18; however, two notable deletions were identified in ORF22. This study is the first report to map a leaf shape gene in watermelon and will facilitate cloning and functional characterization of ClLL1 in future studies.

  7. [Psychometric properties of Q-DIO, an instrument to measure the quality of documented nursing diagnoses, interventions and outcomes].

    Science.gov (United States)

    Müller-Staub, Maria; Lunney, Margaret; Lavin, Mary Ann; Needham, Ian; Odenbreit, Matthias; van Achterberg, Theo

    2010-04-01

    The instrument Q-DIO was developed in the years 2005 till 2006 to measure the quality of documented nursing diagnoses, interventions, and nursing sensitive patient outcomes. Testing psychometric properties of the Q-DIO (Quality of nursing Diagnoses, Interventions and Outcomes.) was the study aim. Instrument testing included internal consistency, test-retest reliability, interrater reliability, item analyses, and an assessment of the objectivity. To render variation in scores, a random strata sample of 60 nursing documentations was drawn. The strata represented 30 nursing documentations with and 30 without application of theory based, standardised nursing language. Internal consistency of the subscale nursing diagnoses as process showed Cronbach's Alpha 0.83 [0.78, 0.88]; nursing diagnoses as product 0.98 [0.94, 0.99]; nursing interventions 0.90 [0.85, 0.94]; and nursing-sensitive patient outcomes 0.99 [0.95, 0.99]. With Cohen's Kappa of 0.95, the intrarater reliability was good. The interrater reliability showed a Kappa of 0.94 [0.90, 0.96]. Item analyses confirmed the fulfilment of criteria for degree of difficulty and discriminative validity of the items. In this study, Q-DIO has shown to be a reliable instrument. It allows measuring the documented quality of nursing diagnoses, interventions and outcomes with and without implementation of theory based, standardised nursing languages. Studies for further testing of Q-DIO in other settings are recommended. The results implicitly support the use of nursing classifications such as NANDA, NIC and NOC.

  8. Intervenções em assédio moral no trabalho: uma revisão da literatura

    Directory of Open Access Journals (Sweden)

    Débora Miriam Raab Glina

    Full Text Available JUSTIFICATIVA: Embora a problemática do assédio moral no trabalho venha sendo estudada há mais de três décadas, aspectos de gerenciamento e prevenção ainda necessitam de maior estudo e sistematização. OBJETIVO: Identificar e sistematizar os métodos de intervenção em assédio moral. MÉTODO: Pesquisa bibliográfica sobre o tema em bases de dados (Medline, Psychinfo, SciELO e Lilacs, livros, teses e sites especializados (1980 a 2010. RESULTADOS E DISCUSSÃO: O conceito de assédio moral no trabalho é inicialmente delimitado, explicitando os elementos caracterizadores básicos. As intervenções são organizadas em níveis de prevenção (primária, secundária e terciária e alvos das ações: indivíduos diretamente envolvidos, testemunhas, grupo de trabalho e organização. Os aspectos que levam ao sucesso das intervenções e às boas práticas são elencados. CONCLUSÃO: Dada a natureza complexa do assédio moral no trabalho, intervenções isoladas e pontuais não funcionam. A abordagem precisa ser abrangente e o acompanhamento das ações, sistemático. Cada caso é singular e o desenho da intervenção deve considerar o contexto organizacional e envolver os vários atores sociais.

  9. Kablosuz Duyarga Ağları ile Engelli İnsanlar İçin Akıllı Ev Uygulamaları

    OpenAIRE

    Işılak, Ali Haktan; Baydere, Şebnem

    2011-01-01

    Akıllı evler geleceğin tasarım kavramları arasında olmaktan çıkmıştır. Günümüzde, içinde yaşayanların yaşam tarzlarını doğrudan etkileyen evler tasarlanmaktadır. Akıllı ev sistemlerinin amacı, tanımlanmış aktivitelerin farkında olan bir ortam yaratmaktır. Engelli insanlar günlük hayatlarını kolaylaştırmak için bu sistemlere ihtiyaç duymaktadırlar. Bu çalışmada engelli insanların hayatlarını kolaylaştırmak amacıyla farklı engel türleri için duyarga ağları ile bazı akıllı ev uygulamaları gelişt...

  10. Biochemical and phylogenetic characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes identifies a diverged form of LL-diaminopimelate aminotransferase.

    Science.gov (United States)

    Hudson, André O; Gilvarg, Charles; Leustek, Thomas

    2008-05-01

    A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an LL-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of L-2,3,4,5-tetrahydrodipicolinate to LL-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with other dap genes, suggestive of a polycistronic structure. The DapL candidate enzymes were found to cluster into two classes sharing approximately 30% amino acid identity. The function of selected enzymes from each class was studied. Both classes were able to functionally complement Escherichia coli dapD and dapE mutants and to catalyze LL-DAP transamination, providing functional evidence for a role in DAP/lysine biosynthesis. In all cases the occurrence of dapL in a species correlated with the absence of genes for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase. The results indicate that the DapL pathway is restricted to specific lineages of eubacteria including the Cyanobacteria, Desulfuromonadales, Firmicutes, Bacteroidetes, Chlamydiae, Spirochaeta, and Chloroflexi and two archaeal groups, the Methanobacteriaceae and Archaeoglobaceae.

  11. M4FT-16LL080303052-State of Knowledge for Colloid Facilitated Radionuclide Transport and Update on Actinide Diffusion in Bentonite Backfill

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Inst.. Physical and Life Sciences; Joseph, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Inst.. Physical and Life Sciences

    2016-08-16

    This progress report (Level 4 Milestone Number M4FT-16LL080303052) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Crystalline Disposal R&D Activity Number FT-16LL080303051 and Crystalline International Collaborations Activity Number FT-16LL080303061. The focus of this research is the interaction of radionuclides with Engineered Barrier System (EBS) and host rock materials at various physico-chemical conditions relevant to subsurface repository environments. They include both chemical and physical processes such as solubility, sorption, and diffusion. The colloid-facilitated transport effort focused on preparation of a draft manuscript summarizing the state of knowledge and parameterization of colloid-facilitated transport mechanisms in support of reactive transport and performance assessment models for generic crystalline repositories. This draft manuscript is being submitted as a level 3 milestone with LANL as the primary author. LLNL’s contribution to that effort is summarized only briefly in the present report. A manuscript summarizing long-term U(VI) diffusion experiments through bentonite backfill material was recently accepted for publication; the contents of that manuscript are summarized in the present report. The Np(IV) diffusion experiments were started mid-year and are ongoing. The completion of these experiments is planned for early FY17. Our progress in quantifying Np(IV) diffusion in bentonite backfill is summarized in the present report. Our involvement with the NEA TDB project was summarized in a recent Argillite Disposal activity report. It is not included in this report.

  12. Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice.

    Science.gov (United States)

    Kim, Miri; Kim, Jongsic; Jeong, Seo-Won; Jo, Hyunmu; Park, Hyun Jeong

    2018-02-01

    Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser (LPND) effectively treats rosacea, although the underlying mechanism is unclear, to evaluate the histological effects and molecular mechanism of LPND on LL-37-induced rosacea-like skin lesions in mice. Intradermal injection of LL-37 was performed into the dorsal skin of BALB/c mice (n = 30) twice a day for 2 days. Fifteen mice were treated with LPND. After 48 h, the excised skin sample was stained for histology and type I collagen; transforming growth factor (TGF)-β, matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinase (TIMP)-1, tumor necrosis factor (TNF)-α, and interleukin (IL)-1α mRNA levels were determined by real-time RT-PCR. Intradermal injection of LL-37 induced rosacea-like clinical features. LPND treatment significantly reduced erythema and increased dermal collagen production. Levels of Type I collagen, TGF-β, and MMP-1 mRNA were significantly higher in LPND-treated mice than in untreated mice. LPND may improve rosacea by ameliorating dermal connective tissue disorganization and elastosis through MMP-mediated dermal collagen remodeling.

  13. The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania.

    Science.gov (United States)

    Tinoco-Nunes, Bruno; Telleria, Erich Loza; da Silva-Neves, Monique; Marques, Christiane; Azevedo-Brito, Daisy Aline; Pitaluga, André Nóbrega; Traub-Csekö, Yara Maria

    2016-04-20

    Lutzomyia longipalpis is the main vector of visceral leishmaniasis in Latin America. Sandfly immune responses are poorly understood. In previous work we showed that these vector insects respond to bacterial infections by modulating a defensin gene expression and activate the Imd pathway in response to Leishmania infection. Aspects of innate immune pathways in insects (including mosquito vectors of human diseases) have been revealed by studying insect cell lines, and we have previously demonstrated antiviral responses in the L. longipalpis embryonic cell line LL5. The expression patterns of antimicrobial peptides (AMPs) and transcription factors were evaluated after silencing the repressors of the Toll pathway (cactus) and Imd pathway (caspar). AMPs and transcription factor expression patterns were also evaluated after challenge with heat-killed bacteria, heat-killed yeast, or live Leishmania. These studies showed that LL5 cells have active Toll and Imd pathways, since they displayed an increased expression of AMP genes following silencing of the repressors cactus and caspar, respectively. These pathways were also activated by challenges with bacteria, yeast and Leishmania infantum chagasi. We demonstrated that L. longipalpis LL5 embryonic cells respond to immune stimuli and are therefore a good model to study the immunological pathways of this important vector of leishmaniasis.

  14. Educação profissional integrada ao ensino médio no Paraná: limites e possibilidades

    Directory of Open Access Journals (Sweden)

    Eliane Cleide da Silva Czernisz

    2015-08-01

    Full Text Available Este texto analisa a integração do ensino médio à educação profissional, desenvolvida pelo Estado do Paraná no período de 2003 a 2010. Os argumentos apresentados foram obtidos a partir de discussão bibliográfica e análise de documentos e legislação da educação, que fundamentam também as questões relativas ao sentido assumido pelo currículo para o processo de integração da educação profissional ao ensino médio no Paraná. A análise realizada permite observar que os percalços que se apresentaram durante tal processo indicam divisões e antagonismos que se encontram na base da organização da sociedade capitalista e, por isso mesmo, representam importante complexidade. Também possibilita o entendimento da constante necessidade de reflexão acerca dos limites e possibilidades da educação profissional integrada ao ensino médio como uma questão imprescindível a um país que busca o desenvolvimento, mas que tem, fundamentalmente, o dever de pensar na melhoria das condições de vida dos trabalhadores garantindo-lhes a formação profissional como direito social.

  15. Homicídio juvenil por arma de fogo e reorganização familiar: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Domingues, Daniela Fontoura

    2011-01-01

    Full Text Available No Brasil, a morte de jovens provocada por armas de fogo tem vitimado inúmeras famílias, exigindo ajustes no sistema familiar para lidar com a perda. Este estudo de caso teve por objetivo investigar fatores de risco e de proteção que interferiram na reorganização da família de um jovem vitimado por homicídio por arma de fogo, nos primeiros cinco anos após o episódio. Participaram da pesquisa a mãe e uma das irmãs da vítima, que responderam a um questionário de caracterização do sistema familiar e a uma entrevista semiestruturada, submetida à análise dos núcleos de sentido. Foram identificados três núcleos: os sentimentos vivenciados frente à perda, o modo como a família lidou com a situação e as mudanças decorrentes do homicídio. O estudo apontou a presença tanto de fatores de risco quanto de proteção que influenciaram as relações interpessoais e a reorganização da família do jovem

  16. “QUERO MATAR MEU CHEFE”: RETALIAÇÃO E AÇÕES DE ASSÉDIO MORAL

    Directory of Open Access Journals (Sweden)

    Diego de Queiroz Machado

    2013-05-01

    Full Text Available Este trabalho tem como objetivo apresentar, através de um estudo observacional, uma análise dos elementos relacionados às práticas de assédio moral no contexto organizacional. Como fonte de dados narrativos, o filme “Quero matar meu chefe” foi escolhido e analisado mediante uma abordagem qualitativa, possibilitando a observação e mapeamento dos principais elementos que circundam os eventos de assédio moral nas organizações bem como suas consequências. A percepção dos problemas gerados pelas diversas práticas de assédio moral, evidenciados pelas teorias apresentadas e ressaltados ao longo do filme, aponta para a importância do apoio das gerências organizacionais como mediadores de tais conflitos. Ademais, o exercício do poder formal aliado a práticas de coerção ressalta-se como um fenômeno que merece aprofundamento, de forma a ser possível identificar todas as variáveis que influenciam e impactam tal processo.

  17. Cosmogenic radionuclides and mineralogical properties of the Chelyabinsk (LL5) meteorite: What do we learn about the meteoroid?

    Science.gov (United States)

    Povinec, Pavel P.; Laubenstein, Matthias; Jull, A. J. Timothy; FerrièRe, Ludovic; BrandstäTter, Franz; Sýkora, Ivan; Masarik, Jozef; BeåO, Juraj; KováčIk, Andrej; Topa, Dan; Koeberl, Christian

    2015-02-01

    On February 15, 2013, after the observation of a brilliant fireball and a spectacular airburst over the southern Ural region (Russia), thousands of stones fell and were rapidly recovered, bringing some extremely fresh material for scientific investigations. We undertook a multidisciplinary study of a dozen stones of the Chelyabinsk meteorite, including petrographic and microprobe investigations to unravel intrinsic characteristics of this meteorite. We also study the short and long-lived cosmogenic radionuclides to characterize the initial meteoroid size and exposure age. Petrographic observations, as well as the mineral compositions obtained by electron microprobe analyses, allow us to confirm the classification of the Chelyabinsk meteorite as an LL5 chondrite. The fragments studied, a few of which are impact melt rocks, contain abundant shock melt veins and melt pockets. It is likely that the catastrophic explosion and fragmentation of the Chelyabinsk meteoroid into thousands of stones was in part determined by the initial state of the meteoroid. The radionuclide results obtained show a wide range of concentrations of 14C, 22Na, 26Al, 54Mn, 57Co, 58Co, and 60Co, which indicate that the pre-atmospheric object had a radius >5 m, consistent with other size estimates based on the magnitude of the airburst caused by the atmospheric entry and breakup of the Chelyabinsk meteoroid. Considering the observed 26Al activities of the investigated samples, Monte Carlo simulations, and taking into account the 26Al half-life (0.717 Myr), the cosmic-ray exposure age of the Chelyabinsk meteorite is estimated to be 1.2 ± 0.2 Myr. In contrast to the other radionuclides, 14C showed a very large range only consistent with most samples having been exposed to anthropogenic sources of 14C, which we associate with radioactive contamination of the Chelyabinsk region by past nuclear accidents and waste disposal, which has also been confirmed by elevated levels of anthropogenic 137Cs and

  18. Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and Ameliorate Metabolic Disturbances in Transgenic Spontaneously Hypertensive Rats

    Czech Academy of Sciences Publication Activity Database

    Šilhavý, Jan; Zídek, Václav; Mlejnek, Petr; Landa, Vladimír; Šimáková, Miroslava; Strnad, Hynek; Oliyarnyk, O.; Škop, V.; Kazdová, L.; Kurtz, T.; Pravenec, Michal

    2014-01-01

    Roč. 9, č. 7 (2014), e101906 E-ISSN 1932-6203 R&D Projects: GA MZd(CZ) NT14325; GA MŠk(CZ) LH12061; GA MŠk(CZ) LL1204 Institutional support: RVO:67985823 ; RVO:68378050 Keywords : fumaric acid esters * C-reactive protein * transgenic * spontaneously hypertensive rat Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.234, year: 2014

  19. Direitos Humanos e Homofobia: por um enfrentamento do medo e do ódio.

    Directory of Open Access Journals (Sweden)

    Luciana de Oliveira Dias

    2015-12-01

    Full Text Available A palavra homofobia não expressa toda a carga de ódio e agressividade que pode ser direcionada a uma pessoa homossexual. Um pertinente questionamento é em que medida este tipo de comportamento pode ser classificado como uma fobia? Em que medida a redução do ódio e agressividade à noção de fobia colabora para patologizar uma ação que poderia ser tipificada como criminosa? Neste artigo problematizamos a limitação etimológica do termo e chamamos a atenção para a necessidade de uma ressignificação da percepção do sujeito intolerante-agressivo. Questões de direitos humanos são apontadas como caminho possível para a constituição de interações socioculturais menos naturalizadas e restituidoras da dignidade humana a sujeitos violentados. Palavras-chave: Homofobia; Patologia; Intolerância; Direitos Humanos. *** Abstract Is the word homophobia able to mean the entire amount of hate and aggressiveness addressed to the individual who suffer this kind of aggression? Can this behavior be classified as a sort phobia? In this article we examine if the use of this term contributes to build a view of the intolerant-aggressive one as a pathological individual. The realization of human rights is the possible way to establish fair social interactions. In situations of justice are reduced the naturalization process and also the human dignity may be restored to the victims of violence. Keywords: Homophobia; Pathology; Intolerance; Human Rights. *** Resumen La palabra homofobia no expresa todo el potencial de odio y agresión que se dirige a una persona gay en determinadas situaciones. ¿Hasta qué punto este tipo de comportamiento puede ser clasificado como una fobia? ¿Hasta qué punto la idea asociada con fobia contribuye a convertir a patológica una acción que podría ser tipificada como un delito? En este artículo se cuestiona la limitación etimológica del término, y llamamos la atención sobre la necesidad de una redefinición de

  20. El Dios iranio Mithra y la Monarquía Persa Aqueménida

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    Israel Campo Méndez

    2013-11-01

    Full Text Available La figura del dios Mithra encarna en el mundo iranio antiguo la divinización de la idea de contrato. Desde el periodo de las tribus indo-arias que se asientan en la región desde mitad del Segundo Milenio a.c. el culto de esta divinidad evoluciona, vinculándose de manera especial con el poder político que ostentan los reyes y jefes tribales. El período de formación del Imperio Persa, bajo la dinastía aqueménida se convierte en un momento histórico importante, en el cual la presencia de Mithra logra mantenerse y seguir vinculada al poder real, a pesar de la implantación de la reforma zoroastriana, que en un principio desplaza su culto.The figure of the god Mithra embodies in the Ancient lranian World the deification of the contract idea. From the period of the Indo-Aryan tribes, settled in the region from half of the Second Millennium B.C., the cult of this divinity evolves, being linked in a special way with the political power that the kings and tribal bosses show. The period of formation of the Persian Empire, under the Aquemenid Dynasty becomes an important historical moment, in which the presence of Mithra is able  to stay and to continue linked to the royal power, in spite of the installation of the zoroastrian reformation that displaces its cult in a principle.

  1. Mobilidade e rendimento escolar dos estudantes de ensino médio em Natal (RN, Brasil

    Directory of Open Access Journals (Sweden)

    William de Mendonça Lima

    2018-02-01

    Full Text Available Resumo Pouco explorado pela literatura, os deslocamentos diários casa-escola refletem uma incoerência espacial entre a distribuição da população em idade escolar e os estabelecimentos de ensino de educação básica (nível médio em Natal, RN. Neste trabalho exploraremos o perfil dos comutadores (estudantes a partir de um recorte político-administrativo intramunicipal. Dessa forma foi possível captar os fluxos diários de estudantes entre os bairros do município de Natal. Para isso, utilizamos o conceito de espaço de vida como embasamento teórico e o banco de dados do Censo Escolar 2012. Assim, relacionando as informações referentes à localidade de residência e de estudos dos alunos, verificou-se a relação entre o deslocamento para estudo e o desempenho escolar medido através do indicador de distorção idade-série em um modelo de regressão logística. Entre os resultados encontrados identificou-se que a chance de um aluno ter um bom rendimento escolar não está relacionada com a proximidade de sua residência da escola. Nesse sentido, a dinâmica da população em termos de distribuição escolar e de alunos pode representar aspectos importantes para a gestão urbana e a oferta de serviços educacionais, sobretudo em um contexto no qual as tendências demográficas apontam para uma redução expressiva da população em idade escolar nos próximos anos.

  2. O ENSINO MÉDIO MINISTRADO NO CENTRO EDUCACIONAL PATATIVA DO ASSARÉ

    Directory of Open Access Journals (Sweden)

    L. M. F. Fialho

    2012-05-01

    Full Text Available O Centro Educacional Patativa do Assaré (CEPA é uma unidade de “ressocialização” para jovens de dezessete anos em conflito com a lei do sexo masculino que cumprem medida socioeducativa de internação, na cidade de Fortaleza, Ceará. Foi adotada a abordagem qualitativa (MINAYO, 2003 para realizar um estudo de caso referente à educação escolar ministrada no CEPA, com entrevistas e diário de campo como procedimentos metodológicos. Através da observação foi possível averiguar que a instituição possui cinco salas de aula adequadas, mas os alunos só desfrutam de duas horas diárias de aula. O ensino médio é ministrado através do Ensino de Jovens e Adultos (EJA, independente da distorção entre série e idade, respeitando um sistema interno de rodízio. A análise das entrevistas, com os sete participantes, possibilitou constatar que: a frequência às salas de aula configura a atividade mais desejada pelos jovens; a educação escolar é suspensa sempre que eles são punidos por comportamento disciplinar indesejado; o tempo de aula é insuficiente; e a educação não contempla sua finalidade legal de desenvolver o educando para o exercício da cidadania e para a progressão em estudos posteriores.

  3. Universidade Acessível: com a Voz os Estudantes Surdos do Ensino Médio

    Directory of Open Access Journals (Sweden)

    Adelso Fidelis de MOURA

    Full Text Available RESUMO o sistema educacional tem dificultado o acesso à escola e/ou à classe bilíngue para os surdos, ofertando essencialmente o atendimento especializado no contraturno para alunos da Educação Infantil e dos anos iniciais do Ensino Fundamental. Esse modo de organização do ensino, aliado à falta de reconhecimento dos estudantes surdos, enquanto grupo linguístico minoritário, colaboram para mantê-los afastados da universidade. O texto em questão retrata as expectativas de acesso ao Ensino Superior por estudantes surdos. Sete estudantes surdos, que utilizavam a Libras (Língua Brasileira de Sinais, participaram do estudo. Eles estavam matriculados no Ensino Médio em uma escola da rede pública estadual de ensino de um município do Oeste Paulista. Os dados foram coletados por meio de entrevistas individuais realizadas em Libras e filmadas para posterior transcrição para a Língua Portuguesa. A análise recaiu sobre o tema Expectativa de Acesso ao Ensino Superior. Os facilitadores e as barreiras reconhecidas por esses alunos para acessar o Ensino Superior foram identificadas. Grande parte dos alunos manifestou o desejo de ingressar na universidade e de continuar seus estudos. A falta de preparo e orientação da escola básica para garantir os conhecimentos científicos necessários a essa finalidade aliada à ausência do profissional tradutor/intérprete de Libras/Português no contexto universitário foram consideradas como os maiores obstáculos para o ingresso na universidade.

  4. Technology-enhanced language learning (TeLL: An update and a principled framework for English for Academic Purposes (EAP courses / L'apprentissage des langues assisté par la technologie (TeLL: mise à jour et énoncé de principes pour les cours

    Directory of Open Access Journals (Sweden)

    Juliana Chau

    2014-05-01

    Full Text Available The range and number of technologies currently available have yielded both opportunities and challenges for language educators. This study aims to review recent technology-enhanced language learning (TeLL research, and to examine their potential relevance to EAP pedagogy, curricula, assessment and instruction. The results of this study show TeLL research with rising interest in vocabulary, grammar and writing, but less so in speaking, listening, and reading. The results also reveal a shift from a tool-centric view of technology use to one that emphasises the technology-pedagogy-human alliance in the last decade, noting three emerging trends in recent TeLL studies, namely, those that are multi-purpose, multi-genre, and multi-role/skill in design and evaluation. The lack of a holistic approach to TeLL for EAP courses to date, however, has made it necessary and desirable to develop a framework for EAP-specific TeLL, to identify a principle for a generic TeLL programme, and to propound ways of operationalizing such a framework. L'apprentissage des langues assisté par la technologie (TeLL: mise à jour et énoncé de principes pour les cours d’anglais à des fins universitaires La variété et la profusion de technologies actuellement disponibles ont engendré des possibilités nouvelles et des défis pour les enseignants en langue. Cette étude passe en revue la recherche récente consacrée à l'apprentissage des langues assisté par la technologie (TeLL et examine sa pertinence éventuelle pour la pédagogie, les programmes, l'évaluation et l'enseignement de l’anglais à des fins universitaires. Les résultats de cette étude révèlent un intérêt croissant de la recherche sur l'apprentissage des langues assisté par la technologie pour le vocabulaire, la grammaire et l'écriture, mais un intérêt moindre pour la langue parlée, la langue écoutée et pour la lecture. Les résultats révèlent aussi que, dans la dernière décennie, on

  5. Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.

    Science.gov (United States)

    Shih, Shen-Liang; Lin, Yin-Shiou; Lin, Shyr-Yi; Hou, Wen-Chi

    2015-12-01

    The metabolic syndrome (MS) is termed a cluster of multiple metabolic risk criteria which is positively correlated with cardiovascular disease and type 2 diabetes mellitus (DM). Yam dioscorins have been reported to exhibit biological activities, however, little is known their preventive effects on the MS. Therefore, a high-fat (HF) diet was used to induce Wistar rat obesity and then yam dioscorin (50 mg/kg, dio50) was intervened daily concurrent HF diet (HF diet + dio50) for five weeks to check the changes of weights of body and tissues, blood pressures, and impaired glucose tolerances. The in vitro peptic hydrolysates of dioscorin with molecular mass between 3 kDa and 10 kDa and less than 3 kDa were used to determine dipeptidyl peptidase IV (DPP IV) inhibitory activities which DPP IV inhibitor has been reported to prevent and treat type 2 DM. There were no significant difference in body weights, feed intakes, feed conversion, and weights of adipose tissues of obese rats in groups of HF and (HF diet + dio50). However, the systolic blood pressures in obese rats of 2-, 3- and 4-week dioscorin interventions were showed significantly lower (P dioscorin intervention (HF+ dio50) was showed significantly different (P dioscorin peptic hydrolysates (5 mg/ml) showed inhibitory activities against DPP IV using sitagliptin phosphate as positive controls. Yam dioscorins exhibit improved MS activities in obese rats which the related mechanisms may need further investigations.

  6. EFEITO DO ENSACAMENTO NA QUALIDADE DE MAÇÃS EM DIFERENTES ESTÁDIOS DE DESENVOLVIMENTO

    Directory of Open Access Journals (Sweden)

    JANAÍNA PEREIRA DOS SANTOS

    2015-09-01

    Full Text Available RESUMO O objetivo deste trabalho foi avaliar a influência do ensacamento na qualidade de maçãs em diferentes estádios de desenvolvimento. Oestudo foi conduzido em pomar orgânico, na Estação Experimental da Epagri de Caçador-SC, durante as safras de 2009/2010 e 2010/2011. Os genótipos de macieira avaliados foram ‘Royal Gala’, ‘Fuji Suprema’, ‘Catarina’ e a seleção M-11/00. Os frutos foram avaliados nos estádios de desenvolvimento intermediário (metade do ciclo, na colheita (maturação comercial e sete dias após a colheita, e em duas diferentescondições (tratamentos: ensacados e não ensacados. O ensacamento foi realizado após o raleio, com embalagens de tecido não texturizado (TNT de coloração branca, quando os frutos apresentavam em torno de 20 mm de diâmetro. Os fatores físico-químicos avaliados foram: cor de fundo, diâmetro, massa fresca, firmeza da polpa, índice de amido, acidez titulável e sólidos solúveis totais. Verificou-se que o ensacamento não interferiu na cor de fundo dos frutos nem no teor de sólidos solúveis totais. Entretanto, dependendo do genótipo de macieira e do estádio de desenvolvimento, houve alteração no diâmetro, na massa fresca, na firmeza, no índice de amido e na acidez titulável dos frutos. O ensacamento pode proporcionar frutos maiores e mais pesados, podendo também antecipar a maturação, caracterizada pela redução da firmeza da polpa e pelo aumento do índice de amido. Em alguns genótipos e estádios de desenvolvimento, os valores médios de acidez titulável foram inferiores nos frutos ensacados.

  7. O suicídio e sua relação com o comportamento impulsivo-agressivo

    Directory of Open Access Journals (Sweden)

    Gustavo Turecki

    1999-10-01

    Full Text Available O suicídio é um sério problema de saúde pública, principalmente em países desenvolvidos, onde as altas taxas de suicídio entre jovens adultos do sexo masculino fazem com que este seja uma das principais causas de morte e de anos potenciais de vida perdidos. A etiologia do suicídio é certamente complexa, com diversos fatores contribuindo para a predisposição a este evento. Entre estes se encontram os fatores genéticos. Nos últimos anos, diversos estudos genético-epidemiológicos têm consistentemente sugerido que o componente genético é significativo. Entretanto, o modo exato através do qual os genes aumentam a predisposição de certos indivíduos a cometer o suicídio é ainda desconhecido. Há evidência crescente de que os fatores genéticos devem influenciar a predisposição ao suicídio via uma modulação dos comportamentos impulsivo e impulsivo-agressivo. Este artigo revisa e discute os estudos que investigaram fatores genéticos no comportamento suicida, assim como esta relação com os traços impulsivo-agressivos.Suicide is a serious public-health problem, particularly in developed countries, where high suicide rates among young males are considerably high. Indeed, suicide is one of the leading causes of death and of potential years of life lost. The etiology of suicide is certainly complex, with different factors likely playing an important role. Among these are genetic factors, as consistently suggested by several genetic-epidemiological studies that have been carried out over the last years. However, the exact mechanism by which genes increase susceptibility to suicide is not known. Several lines of evidence suggest that genes may predispose to suicide by modulating impulsive and impulsive-aggressive behaviors. In this review, studies that investigated the role of genetic factors in suicidal behavior, as well as the relationship to impulsive-aggressive traits, arediscussed.

  8. Lectins from Synadenium carinatum (ScLL) and Artocarpus heterophyllus (ArtinM) Are Able to Induce Beneficial Immunomodulatory Effects in a Murine Model for Treatment of Toxoplasma gondii Infection.

    Science.gov (United States)

    Ramos, Eliézer L P; Santana, Silas S; Silva, Murilo V; Santiago, Fernanda M; Mineo, Tiago W P; Mineo, José R

    2016-01-01

    Infection by Toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine, and folinic acid. However, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. Thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients with toxoplasmosis. It has been described that lectins from plants can control parasite infections, when used as immunological adjuvants in vaccination procedures. This type of lectins, such as ArtinM and ScLL is able to induce immunostimulatory activities, including efficient immune response against parasites. The present study aimed to evaluate the potential immunostimulatory effect of ScLL and ArtinM for treatment of T. gondii infection during acute phase, considering that there is no study in the literature accomplishing this issue. For this purpose, bone marrow-derived macrophages (BMDMs) were treated with different concentrations from each lectin to determine the maximum concentration without or with lowest cytotoxic effect. After, it was also measured the cytokine levels produced by these cells when stimulated by the selected concentrations of lectins. We found that ScLL showed high capacity to induce of pro-inflammatory cytokine production, while ArtinM was able to induce especially an anti-inflammatory cytokines production. Furthermore, both lectins were able to increase NO levels. Next, we evaluated the treatment effect of ScLL and ArtinM in C57BL/6 mice infected by ME49 strain from T. gondii . The animals were infected and treated with ScLL, ArtinM, ArtinM plus ScLL, or sulfadiazine, and the following parameters analyzed: Cytokines production, brain parasite burden and survival rates. Our results demonstrated that the ScLL or ScLL plus ArtinM treatment induced

  9. Lectins from Synadenium carinatum (ScLL and Artocarpus heterophyllus (ArtinM are able to induce beneficial immunomodulatory effects in a murine model for treatment of Toxoplasma gondii infection

    Directory of Open Access Journals (Sweden)

    Leandro Peixoto Ferreira Souza

    2016-11-01

    Full Text Available Infection by Toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine and folinic acid. However, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. Thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients with toxoplasmosis. It has been described that lectins from plants can control parasite infections, when used as immunological adjuvants in vaccination procedures. This type of lectins, such as ArtinM and ScLL is able to induce immunostimulatory activities, including efficient immune response against parasites. The present study aimed to evaluate the potential immunostimulatory effect of ScLL and ArtinM for treatment of T. gondii infection during acute phase, considering that there is no study in the literature accomplishing this issue. For this purpose, bone marrow-derived macrophages (BMDMs were treated with different concentrations from each lectin to determine the maximum concentration without or with lowest cytotoxic effect. After, it was also measured the cytokine levels produced by these cells when stimulated by the selected concentrations of lectins. We found that ScLL showed high capacity to induce of pro-inflammatory cytokine production, while ArtinM was able to induce especially an anti-inflammatory cytokines production. Furthermore, both lectins were able to increase NO levels. Next, we evaluated the treatment effect of ScLL and ArtinM in C57BL/6 mice infected by ME49 strain from T. gondii. The animals were infected and treated with ScLL, ArtinM, ArtinM plus ScLL or sulfadiazine, and the following parameters analyzed: cytokines production, brain parasite burden and survival rates. Our results demonstrated that the ScLL or ScLL plus Artin

  10. A FREQUENTE LUTA DAS MULHERES POR PUNIÇÕES AOS SEUS AGRESSORES: FEMINICÍDIO X LEI MARIA DA PENHA

    Directory of Open Access Journals (Sweden)

    Brizza Oliveira Lima

    2017-03-01

    Full Text Available Resumo: Ainda que existam leis no ordenamento jurídico brasileiro que visam proteger os direitos humanos das mulheres, como a lei nº 11.340 de 07 de Agosto de 2006 – Lei Maria da Penha, e a mais recente, lei nº 13.104 de 09 de março de 2015 – Lei do Feminicídio, que inseriu no §2º do artigo 121, do Código Penal a figura do feminicídio como qualificadora do crime de homicídio, perdura ainda, a persistência da violência contra a mulher. Este artigo busca responder a seguinte questão: Se a Lei Maria da Penha fosse mais bem estruturada na sua aplicabilidade, o Feminicídio diminuiria? Com base nas informações coletadas em artigos científicos, pesquisas, leis e em doutrinas do Direito das quais demonstram que a figura do Feminicídio, pode em certas hipóteses imiscuir-se no conhecimento da Lei Maria da Penha, a qual ao ponto de vista deste estudo poderia prevenir diversos feminicídios, preservando a vida de cada uma das mulheres violentadas e muitas vezes mortas.

  11. A Dinâmica e os Fatores Organizacionais Propiciadores à Ocorrência do Assédio Moral no Trabalho

    Directory of Open Access Journals (Sweden)

    Thiago Soares Nunes

    2013-11-01

    Full Text Available Neste artigo é apresentada uma revisão da literatura sobre o assédio moral, com uma abordagem voltada para a Ciência da Administração. Considera-se que no atual contexto existem alguns fatores organizacionais propiciadores à ocorrência do assédio moral, e que são importantes de ser compreendidos pelo administrador. O assédio moral trata-se de um processo complexo que inclui a interação de aspectos interpessoais, sociais (grupais e organizacionais. A abordagem focada é a do assédio moral organizacional, cujo objetivo é fazer com que as agressões sirvam de exemplo para os membros organizacionais, para que estes alcancem as metas/objetivos estabelecidos pela organização a qualquer custo. Ressalta-se que existem alguns fatores organizacionais que podem propiciar o assédio, como a mudança da natureza e da organização do trabalho, cultura e clima organizacional, e liderança. Buscaram-se nos modelos propostos subsídios conceituais explicativos do fenômeno, os quais demonstram a interação dos diversos aspectos supracitados que influenciam na ocorrência.DOI:10.7769/gesec.v4i2.161

  12. Measurement of the W ¿ l¿ and Z/¿* ¿ ll production cross sections in proton-proton collisions at vs= 7 TeV with the ATLAS detector

    DEFF Research Database (Denmark)

    Aad...[], G.; Dam, Mogens; Hansen, John Renner

    2010-01-01

    First measurements of the W ¿ l¿ and Z/¿ * ¿ ll (l = e, µ) production cross sections in proton-proton collisions at s=7TeV are presented using data recorded by the ATLAS experiment at the LHC. The results are based on 2250 W ¿ l¿ and 179 Z/¿ * ¿ ll candidate events selected from a data set corres...

  13. Measurement of K/sub NN/, K/sub LL/ in p vector d → n vector X and p vector 9Be → n vector X at 800 MeV

    International Nuclear Information System (INIS)

    Riley, P.J.; Hollas, C.L.; Newsom, C.R.

    1980-01-01

    The spin transfer parameters, K/sub NN/ and K/sub LL/, have been measured in p vector d → n vector X and p vector 9 Be → n vector X at 0 0 and 800 MeV. The rather large values of K/sub LL/ demonstrate that this transfer mechanism will provide a useful source of polarized neutrons at LAMPF energies

  14. Measurement of K/sub NN/, K/sub SS/, K/sub SL/, and K/sub LL/ in polarized np → polarized pn at 800 MeV in the CEX region

    International Nuclear Information System (INIS)

    Ransome, R.D.; Hollas, C.L.; Riley, P.J.

    1980-01-01

    The spin transfer parameters K/sub NN/, K/sub SS/, K/sub SL/, and K/sub LL/ have been measured for np elastic scattering at 800 MeV between 165 0 and 180 0 c.m. The parameters K/sub NN/ and K/sub LL/ are in good agreement with the quasi-free reaction polarized pd → polarized npp at 180 0

  15. Presentación del Libro: “Juan de Dios Carrasquilla, Hombre de Ciencia”

    Directory of Open Access Journals (Sweden)

    Adolfo De Francisco Zea

    2004-06-01

    Full Text Available

    Ha sido tradición y costumbre de esta Corporación que cuando se presenta un libro de alguno de los Académicos en una sesión especial como ésta, su autor disponga de un corto tiempo para exponer ante el auditorio el contenido de la obra presentada; en ocasiones, la exposición es ilustrada con estadísticas o cuadros sinópticos alusivos a los temas de que se ocupa el libro. Si se trata de un estudio biográfico, como el que hoy presento ante ustedes, es usual acompañarlo de fotografías relacionadas con el biografiado, con su entorno familiar, con el medio en el que vivió, estudió y desarrolló los actos más salientes de su vida. En otras palabras, con elementos que tienen que ver con la época en que transcurrió la existencia del personaje estudiado.

    Una presentación del libro, concebida en esa forma, podría convertirse fácilmente en la enumeración de una serie de capítulos cronológicamente organizados en los que se destacan las ejecutorias del personaje y se analizan someramente sus rasgos intelectuales, éticos o espirituales; en el fondo, un compendio apretado, y glacial si se quiere, del contenido real de la obra. Quiero apartarme de este tipo de exposición para leer en su lugar las tres o cuatro páginas de Introducción a la biografía del ilustre médico y naturalista bogotano.

    Juan de Dios Carrasquilla, señores Académicos, fue un verdadero hombre de ciencia en toda la extensión del vocablo; un ser humano, que en síntesis afortunada, supo significar el sentido de una vida como la suya integralmente dedicada al ejercicio de la medicina y al estudio de las ciencias naturales, con las admirables palabras que alguna vez, al referirse a sus estudios de investigación en el terreno de la meteorología, expresara de la siguiente manera: “Someto mis observaciones y deducciones. Si contribuyen en algo al adelanto de la ciencia, daré por bien empleados todos mis esfuerzos; si, por el contrario, a nada

  16. La Cita como suspenso: el Autor-Dios y la Nada

    Directory of Open Access Journals (Sweden)

    Daniel Basilio

    2015-04-01

    Full Text Available [es] Las sociedades modernas están regidas por la idea de Autor, que no es otra cosa que el propio sujeto jurídico, abstracto y autosuficiente que se constituye como individuo canónico de la época. El Autor-Dios vuelve a las obras entes antropomórficos, organismos jerárquicamente delimitados que le pertenecen mediante su firma. Cada obra convive con el suspenso de sus signos muertos, que son resucitados por esos otros, aquellos que anidarán el nuevo porvenir. Este ensayo intenta rescatar el pensamiento de Leibniz y Tarde bajo la concepción de amistad política de Derrida: el origen plural del Ser como una Nada constitutiva que se expresa en el arte de citar. La amistad se erige como un compromiso que sobrevive a la muerte; mediante la escritura queremos dejar algo para los que vendrán; mediante la cita, trascendemos el umbral de la muerte para darle vida a los signos muertos, al legado de aquellos que nos precedieron. Convivimos con una ajenidad fundante. La cita es virus, infección: se interna en la carne para cambiar por completo nuestro sistema de pensamiento. La cita es también profanación: extraemos símbolos del orden de lo sagrado para volverlos al orden de lo real e imprimirles nuestro carácter singular. [en] Modern societies are governed by the idea of an Author, which is a variable of the legal, abstract and self-sufficient subject that is established as the canonic individual of the era. The God-Auhor turns the works in anthropomorphic entities, delimited organisms that belongs to him by his sign. Each work lives in suspense with its dead signs, which will be resurrected by those who will construct the future. This essay is about the thoughts of Leibniz and Tarde about the Derrida´s politics of friendship: the plural origin of Being as Nothingness that expresses the art of quoting. Friendship is a compromise that survives death; the writing lefts its words for those about to come; quoting transcend the threshold of death

  17. ESPORTE COMO SUBSÍDIO AO ENSINO DE FÍSICA: RETRATO DAS PESQUISAS BRASILEIRAS

    Directory of Open Access Journals (Sweden)

    Cleci Teresinha Werner da Rosa

    2016-01-01

    Full Text Available O presente trabalho tem por objetivo identificar, na produção científica brasileira, a presença da temática “esporte” no ensino de Física. De forma mais específica, o estudo analisa artigos de periódicos nacionais de modo a verificar como o esporte tem sido utilizado como subsídio para ensinar conteúdos de Física. Para tanto, selecionou-se periódicos disponíveis on-line com Qualis A1, A2, B1, e B2 no sistema de avaliação da Capes, Área de Ensino, no período de 2005 a 2014. Do universo de 3.923 artigos investigados, nove apresentaram algum tipo de relação entre a Física e o esporte. Tais artigos foram analisados e classificados de modo a se identificar o foco de interesse da investigação, bem como a situação didática a que ele se refere. Como resultado, verificou-se a escassez de trabalhos envolvendo a temática.AbstractThe present study aims to identify, in the Brazilian scientific production, the presence of “sports” thematic in Physics teaching. More specifically, the study analyses articles from national journals in order to verify how sport has been used as a resource for teaching Physics contents. Hence, a selection was made of journals available online with Qualis A1, A2, B1, and B2 in the evaluation system of Capes (Coordination for the Improvement of Higher Education Personnel, Field of Education, from 2005 to 2014. From the universe of 3,923 articles researched, nine of them presented some type of relation between Physics and sport. These articles were analyzed and rated so to identify the interest focus of the research as well as the didactic situation to which they refer. As a result, the shortage of studies involving the theme was verified.

  18. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat

    Czech Academy of Sciences Publication Activity Database

    Liška, F.; Landa, Vladimír; Zídek, Václav; Mlejnek, Petr; Šilhavý, Jan; Šimáková, Miroslava; Strnad, Hynek; Trnovská, J.; Škop, V.; Kazdová, L.; Starker, C.G.; Voytas, D.F.; Izsvák, Z.; Mancini, M.; Šeda, O.; Křen, V.; Pravenec, Michal

    2017-01-01

    Roč. 69, č. 6 (2017), s. 1084-1091 ISSN 0194-911X R&D Projects: GA ČR(CZ) GB14-36804G; GA MŠk(CZ) LL1204 Institutional support: RVO:67985823 ; RVO:68378050 Keywords : fibrosis * hypertension * hypertrophy * left ventricular rats * inbred * SHR * transcriptome Subject RIV: EB - Genetics ; Molecular Biology; EB - Genetics ; Molecular Biology (UMG-J) OBOR OECD: Cardiac and Cardiovascular systems; Cardiac and Cardiovascular systems (UMG-J) Impact factor: 6.857, year: 2016

  19. Protective role of probiotic lactic acid bacteria against dietary fumonisin B1-induced toxicity and DNA-fragmentation in sprague-dawley rats.

    Science.gov (United States)

    Khalil, Ashraf A; Abou-Gabal, Ashgan E; Abdellatef, Amira A; Khalid, Ahmed E

    2015-08-18

    The genus Fusarium, especially F. verticillioides and F. proliferatum, has been found in several agricultural products worldwide, especially in maize. Regardless the occurrence of symptoms, the presence of Fusarium in maize constitutes an imminent risk due to its ability to produce fumonisins, mycotoxins with proven carcinogenic effect on rats, swine, and equines and already classified as possible carcinogens to humans. The toxicity of incremental levels of fumonisin B1 (FB1), that is, 50, 100, and 200 mg FB1/kg diet, and the role of Lactobacillus delbrueckii subsp. lactis DSM 20076 (LL) and Pediococcus acidilactici NNRL B-5627 (PA) supplementation in counteracting the FB1 effects in intoxicated rats were monitored over a period of 4 weeks. Effects on the feed intake and body weight gain were noticed. A significant (p ≤ 0.05) increase in the level of liver and kidney functions markers and DNA fragmentation was also noticed in rat groups T100 and T200. The lactic acid bacteria (LAB) supplementation could bring back the normal serum biochemical parameters in rats fed on fumonisin B1-contaminated diets (T50 and T100) compared to FB1-treated groups. In rats of high-dosage dietary groups supplemented with LAB (T200-LL and T200-PA), the supplementation reduced the serum activity levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine by 11.3, 11.9, 32, and 20%, respectively. DNA fragmentations were observed in the rat group treated with 200 mg FB1 after 3 weeks, while fragmentation was noticed in treated groups with 100 and 200 mg FB1 after 4 weeks. No DNA fragmentation was apparent in FB1-treated rats co-administered the LL or PA strain. These results suggest that in male rats consuming diets containing FB1, there is a time- and dose-dependent increase in serum enzyme activities and DNA lesions. Moreover, Lb. delbrueckii subsp. lactis (LL) and P. acidilactici (PA) strains have a protective effect

  20. Esterase polymorphism in remanant populations of Aspidosperma polyneuron Müll.Arg. (Apocynaceae Polimorfismo de esterases em populações remanescentes de Aspidosperma polyneuron Müll.Arg. (Apocynaceae

    Directory of Open Access Journals (Sweden)

    Vanda Marilza de Carvalho

    2004-10-01

    Full Text Available The population genetic structure of the endangered tree species Aspidosperma polyneuron Mull.Arg. (Apocynaceae was reported based on analysis of esterase polymorphism in two remanant populations. Allelic variation was detected at three isoesterase loci (Est-3, Est-9, and Est-10. The proportion of polymorphic loci for both populations was 30% and deviation from Hardy-Weinberg equilibrium was observed for the Est-3 locus observed in the northern population. Segregation distortion and the lower level of observed and expected heterozygosity in this population were attributed to founder genotype. The high genetic identity values for northern and northwestern populations are in accordance with the low levels of interpopulation genetic divergence demonstrated by the F(ST (0.03 value. The F(IS value (0.23 indicated moderate levels of inbreeding. A. polyneuron can be indicated as an example of endangered species suggesting high genetic variation in contrast to the low genetic variation reported for endangered species. The esterase isozymes may be a good genetic marker for studies of natural A. polyneuron populations.A análise do polimorfismo de isozimas esterases foi usada para reportar a estrutura genética de duas populações remanecentes da espécie de árvore em extinção Aspidosperma polyneuron Müll.Arg. (Apocynaceae. Variação alélica foi detectada em três locos de isoesterases (Est-3, Est-9, e Est-10. A proporção de locos polimórficos de ambas as populações foi de 30%, sendo observado um desvio do equilíbrio de Hardy-Weinberg no loco Est-3 na população da região norte do Estado do Paraná. Uma distorção na segregação e um mais baixo nível de heterozigosidade observada e esperada nesta população foram atribuídos ao efeito do genótipo fundador. Os valores altos de identidade genética das populações do norte e noroeste do Estado estão de acordo com o baixo nível de divergência genética interpopulacional demonstrado

  1. Culturas Juvenis, culturas digitais e Ensino Médio: quando o diálogo é necessário

    Directory of Open Access Journals (Sweden)

    Sueli Salva

    2016-12-01

    Full Text Available Este artigo tem como objetivo refletir acerca do uso das tecnologias digitais no contexto escolar de ensino médio a partir da compreensão dos professores. Apresenta análises da pesquisa “Mídias e Juventude: aspectos educativos e culturais em (desencontro”. A produção dos dados foi realizada no Brasil, na cidade de Santa Maria, em algumas escolas públicas de ensino médio e na Itália em algumas escolas Secundárias de Segundo Grau. Autores como Gil e Micheli (2011, Barbero (2008, Belonni (2013 se constituem como referencial teórico que busca dialogar com as políticas públicas para o ensino médio no Brasil. Foi possível perceber que apesar dos documentos legais preverem a utilização das tecnologias digitais nos contextos escolares, seu uso ainda é restrito em ambos os países em decorrência, da deficiência na formação dos professores, da estrutura rígida da instituição escolar, das frágeis condições estruturais das escolas, falta de compreensão acerca dos aspectos culturais que envolve a vida juvenil, da pouca reflexão acerca da mudança na relação com o saber, provocada pelas tecnologias digitais cujo tema ainda não foi suficientemente explorado.

  2. Inclusão escolar no ensino médio: desafios da prática docente

    Directory of Open Access Journals (Sweden)

    Patrícia Mara Almeida Garcia

    2016-09-01

    Full Text Available Este artigo apresenta os dados de uma pesquisa que desenvolvemos como parte de uma disciplina do Programa de Pós-Graduação em Educação Escolar da FCL/CAr da Unesp, que se propôs a analisar o trabalho docente no contexto da inclusão escolar em todos os níveis de ensino. Realizamos uma pesquisa com professores do Ensino Médio, de uma escola do interior de Minas Gerais, que atendia alunos público-alvo da educação especial - PAEE. O objetivo foi observar e analisar como tem se dado o processo de inclusão nesta unidade escolar, quais os desafios enfrentados e os subsídios oferecidos pela escola. Desenvolvemos uma pesquisa de abordagem qualitativa, utilizamos como procedimento metodológico o Estudo de Caso e como instrumentos de pesquisa usamos um questionário, que foi aplicado a 5 professores, realizamos observações com registro em diário de campo para caracterizar a escola em relação a sua estrutura física e para compreensão dos processos pedagógicos, analisamos o Projeto Político Pedagógico e a dinâmica de estruturação da escola. Os resultados mostram, entre outros, que a inclusão de alunos PAEE no Ensino Médio ainda é muito frágil, que os professores não se sentem preparados e, portanto, não realizam adaptações considerando as diferenças, que o PPP não é elaborado de forma coletiva e participativa e que se faz necessário um engajamento de toda a equipe escolar na busca das alterações necessárias.

  3. DIMENSÕES ESPAÇOTEMPORAIS DOS HOMICÍDIOS NA CIDADE DE PELOTAS – 2012-2015

    Directory of Open Access Journals (Sweden)

    Erika Collischonn

    2017-04-01

    Full Text Available O trabalho que aqui se apresenta buscou avaliar de que forma o Geoprocessamento pode contribuir para compreender a relação entre crimes de Homicídios e de Tráfico de Entorpecentes na cidade de Pelotas, no período de 2012 a 2015. Como base de dados para as análises temporal e espacial foram usados os boletins de ocorrência da Brigada Militar. Os pontos de localização dos crimes foram definidos com base nos endereços constantes no boletim de ocorrência e posteriormente importados como feições de pontos em projeto no programa QGIS, conforme o número da ocorrência. Neste projeto já havia outros planos de informação, contendo atributos sócio econômicos e infra estruturais sobre a cidade. Com base nos dados constatou-se a concentração de homicídios em algumas áreas da cidade e também a relação com aspectos que a literatura de análise da violência e criminalidade urbana vem debatendo. A análise espacial, que apontou concentrações de ocorrências de homicídios na cidade, mostra claramente quais áreas e suas vizinhanças devem ser objeto de políticas públicas que devem ir além de medidas controle da oferta de drogas (repressão e medidas de controle do consumo (prevenção, ou seja, que devem envolver outros órgãos e agências que não apenas a polícia.

  4. Do assédio moral à violência interpessoal: relatos sobre uma empresa júnior

    Directory of Open Access Journals (Sweden)

    Renata de Almeida Bicalho Pinto

    Full Text Available O objetivo deste artigo é analisar a violência interpessoal vivenciada por sujeitos que atuam ou atuaram profissionalmente em uma empresa júnior (EJ. Para tanto, desenvolvemos um referencial teórico que apresenta e pondera sobre a teoria relativa ao assédio moral no trabalho. De modo sucinto, o assédio moral geralmente é caracterizado, nos Estudos Organizacionais, como condutas hostis, impróprias, repetitivas e prolongadas por meio de posturas, palavras, gestos e/ou situações humilhantes que envolvem o trabalhador, ou um grupo, durante a jornada de trabalho. Neste artigo, questionamos o conceito de assédio moral, que é intimamente relacionado à intencionalidade dos sujeitos, e, em contrapartida, propomos o conceito de violência interpessoal, isto é, o ato de agredir o sujeito física e/ou discursivamente e/ou por atitudes e/ou comportamentos prejudiciais, sejam propositais ou não. Em seguida, analisamos alguns relatos de violência interpessoal experienciadas por atuais ou ex-empresários juniores à luz desse conceito; realizamos uma pesquisa empírica de cunho qualitativo, na qual utilizamos a metodologia da história oral e analisamos os dados de acordo com a técnica hermenêutica/dialética. Constatamos que os tipos de violência relatados são, na maioria dos casos, naturalizados pelas próprias vítimas e pelo corpo social em decorrência de uma práxis tida como necessária para a incorporação do sujeito. Destacamos, ainda, o nítido imbricamento das categorias violência interpessoal e violência simbólica.

  5. Biochemical and Phylogenetic Characterization of a Novel Diaminopimelate Biosynthesis Pathway in Prokaryotes Identifies a Diverged Form of ll-Diaminopimelate Aminotransferase▿ †

    Science.gov (United States)

    Hudson, André O.; Gilvarg, Charles; Leustek, Thomas

    2008-01-01

    A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an ll-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of l-2,3,4,5-tetrahydrodipicolinate to ll-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with other dap genes, suggestive of a polycistronic structure. The DapL candidate enzymes were found to cluster into two classes sharing approximately 30% amino acid identity. The function of selected enzymes from each class was studied. Both classes were able to functionally complement Escherichia coli dapD and dapE mutants and to catalyze ll-DAP transamination, providing functional evidence for a role in DAP/lysine biosynthesis. In all cases the occurrence of dapL in a species correlated with the absence of genes for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase. The results indicate that the DapL pathway is restricted to specific lineages of eubacteria including the Cyanobacteria, Desulfuromonadales, Firmicutes, Bacteroidetes, Chlamydiae, Spirochaeta, and Chloroflexi and two archaeal groups, the Methanobacteriaceae and Archaeoglobaceae. PMID:18310350

  6. 1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model.

    Science.gov (United States)

    Gonzalez-Curiel, Irma; Trujillo, Valentin; Montoya-Rosales, Alejandra; Rincon, Kublai; Rivas-Calderon, Bruno; deHaro-Acosta, Jeny; Marin-Luevano, Paulina; Lozano-Lopez, Daniel; Enciso-Moreno, Jose A; Rivas-Santiago, Bruno

    2014-01-01

    Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing. It has been recently reported that patients with DFU have lower levels of antimicrobial peptides (AMPs) at the lesion area, which contributes with the impairment of wound healing. The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3) and L-isoleucine induced HBD-2 and LL-37 in primary cultures from DFU. We developed primary cell cultures from skin biopsies from 15 patients with DFU and 15 from healthy donors. Cultures were treated with 1,25 (OH)2D3 or L-isoleucine for 18 h. Keratinocytes phenotype was identified by western blot and flow cytometry. Real time qPCR for DEFB4, CAMP and VDR gene expression was performed as well as an ELISA to measure HBD-2 and LL-37 in supernatant. Antimicrobial activity, in vitro, wound healing and proliferation assays were performed with conditioned supernatant. The results show that primary culture from DFU treated with 1,25(OH)2D3, increased DEFB4 and CAMP gene expression and increased the production of HBD-2 and LL-37 in the culture supernatant. These supernatants had antimicrobial activity over E. coli and induced remarkable keratinocyte migration. In conclusion the 1,25(OH)2D3 restored the production of AMPs in primary cell from DFU which were capable to improve the in vitro wound healing assays, suggesting their potential therapeutic use on the treatment of DFU.

  7. 1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model.

    Directory of Open Access Journals (Sweden)

    Irma Gonzalez-Curiel

    Full Text Available Diabetic foot ulcers (DFU are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing. It has been recently reported that patients with DFU have lower levels of antimicrobial peptides (AMPs at the lesion area, which contributes with the impairment of wound healing. The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 (1,25 (OH2 D3 and L-isoleucine induced HBD-2 and LL-37 in primary cultures from DFU. We developed primary cell cultures from skin biopsies from 15 patients with DFU and 15 from healthy donors. Cultures were treated with 1,25 (OH2D3 or L-isoleucine for 18 h. Keratinocytes phenotype was identified by western blot and flow cytometry. Real time qPCR for DEFB4, CAMP and VDR gene expression was performed as well as an ELISA to measure HBD-2 and LL-37 in supernatant. Antimicrobial activity, in vitro, wound healing and proliferation assays were performed with conditioned supernatant. The results show that primary culture from DFU treated with 1,25(OH2D3, increased DEFB4 and CAMP gene expression and increased the production of HBD-2 and LL-37 in the culture supernatant. These supernatants had antimicrobial activity over E. coli and induced remarkable keratinocyte migration. In conclusion the 1,25(OH2D3 restored the production of AMPs in primary cell from DFU which were capable to improve the in vitro wound healing assays, suggesting their potential therapeutic use on the treatment of DFU.

  8. Suicide among young people in selected Brazilian State capitals Suicídio de jovens nas principais capitais do Brasil

    Directory of Open Access Journals (Sweden)

    Edinilsa Ramos de Souza

    2002-06-01

    Full Text Available This study analyzes suicide among young Brazilians (15-24 years old in nine metropolitan areas. Mortality data for 1979-1998 were obtained from the Mortality Information System of the Ministry of Health. External causes are the main causes of death among youth, and suicide is the sixth most frequent of these causes. The distribution is heterogeneous, varying according to the social stratum, specific age group, sex, and means used to commit suicide. All cities analyzed showed increased suicide rates from 1979 to 1998 (from 3.5 to 5.0 per 100,000 inhabitants 15-24 years old. Salvador and Rio de Janeiro had the lowest suicide rates, while Porto Alegre and Curitiba had the highest. The principal means used by youth to commit suicide were hanging, strangling, and suffocation (Porto Alegre, followed by firearms and explosives (Belo Horizonte.O presente estudo analisa o comportamento dos suicídios de jovens nas capitais das nove Regiões Metropolitanas brasileiras. Utiliza os dados do Sistema de Informação sobre Mortalidade (SIM do Ministério da Saúde, na faixa etária de 15 a 24 anos, no período de 1979 a 1998. As externas são as principais causes de óbito de jovens e entre elas o suicídio ocupa a 6ª posição, com uma distribuição heterogênea. Sua incidência varia em função dos diferentes espaços sociais, das faixas etárias específicas, do sexo e dos meios utilizados. Para o conjunto das capitais observou-se uma certa elevação das taxas de suicídios nos anos analisados, correspondendo a 3,5 (em 1979, 3,4 (1985, 4,0 (1990 e a 5,0 (em 1998 por 100.000 habitantes de 15 a 24 anos. Salvador e Rio de Janeiro tiveram as menores taxas de suicídio; em contrapartida, Porto Alegre e Curitiba apresentaram as maiores taxas. Os principais meios utilizados para perpetrar tais mortes foram o enforcamento, estrangulamento e sufocação, sobretudo em Porto Alegre, e a utilização de armas de fogo e explosivos, ressaltando-se sua utilização em

  9. Suicídio entre Médicos e Estudantes de Medicina: Revisão de Literatura

    OpenAIRE

    Santa, Nathália Della; Cantilino, Amaury

    2016-01-01

    RESUMO Objetivos O presente estudo tem como objetivo construir uma revisão integrativa de literatura sobre o suicídio em médicos e estudantes de Medicina com base em uma análise de artigos científicos sobre o tema. Métodos Foi realizada uma pesquisa nos bancos de dados PubMed, Lilacs e SciELO com os descritores “suicide”, “physicians”, “doctors” e “students” entre os anos de 2000 e 2014 em língua inglesa, alemã, portuguesa e espanhola. Resultados Os resultados indicaram que as taxas de ...

  10. TEMPO DE TELA, PERCEPÇÃO DA QUALIDADE DE SONO E EPISÓDIOS DE PARASSONIA EM ADOLESCENTES

    Directory of Open Access Journals (Sweden)

    Alison Oliveira da Silva

    Full Text Available RESUMO Introdução: O sono é um importante componente no processo de desenvolvimento biológico e mental das crianças e dos adolescentes, considerado fonte de revitalização das funções orgânicas. Objetivo: Analisar a associação entre o tipo e tempo de exposição à tela, a percepção da qualidade de sono e os episódios de parassonia em adolescentes. Métodos: Estudo transversal que incorpora um levantamento epidemiológico de base escolar com amostra representativa (n = 481 de estudantes (14 a 19 anos do ensino médio da rede pública estadual do município de Caruaru, PE. Para a análise do sono e do estilo de vida, foi utilizada a versão traduzida e adaptada do Global School-Based Student Health Survey (GSHS. Recorreu-se à regressão logística binária para análise da associação entre as variáveis, considerando-se como desfecho a percepção negativa da qualidade de sono. Resultados: A prevalência de percepção negativa da qualidade de sono foi de 58% (IC 95% 53,5-62,3. Entre os comportamentos analisados, verificou-se que dormir oito horas ou menos por dia e assistir mais de duas horas de TV por dia aumentam, respectivamente, 2,69 (IC 95% 1,61-4,71 e 1,71 (IC 95% 1,08-2,73 as chances de relatar percepção negativa de sono. O tempo excessivo de tela, sobretudo diante da TV, esteve associado à maior quantidade de episódios de parassonia. Conclusão: A qualidade do sono está relacionada tanto com a quantidade de horas de sono, quanto com o tempo de exposição à TV. Além disso, uma quantidade maior de episódios de parassonia ocorreu entre os adolescentes que assistem mais de três horas de TV por dia.

  11. O papel da ciência forense na investigação dos crimes de homicídio

    OpenAIRE

    Duarte, Gerson de Lemos

    2009-01-01

    Trabalho final de mestrado integrado em Medicina (Medicina Legal e Ciências Forenses), apresentado á Faculdade de Medicina da Universidade de Coimbra Palavras-chave: Inspecção Judiciária, Vestígios, Sector de Local do Crime, Áreas Técnico-Científicas. Em crimes de carácter mais violento, principalmente nos de homicídio, cumpre à Polícia Judiciária o apuramento das circunstâncias de tempo, lugar e modo em que o exercício da morte ocorreu, tornando-se, desde logo, nuclear ao suce...

  12. Limitação por sódio em assembléias de formigas no cerrado

    OpenAIRE

    Vieira, Jésica

    2014-01-01

    Um grande desafio para qualquer animal é manter o equilíbrio dos múltiplos nutrientes no corpo, em face de um ambiente nutricionalmente heterogêneo. O sódio (Na) é um nutriente essencial para a vida e apesar de se mostrar um nutriente limitante para vários organismos, inclusive para as formigas, pouco se sabe ao certo até que ponto esse nutriente pode ser benéfico. Neste trabalho foi investigada o uso das comunidades de formigas por iscas de sal ou de sacarose em diferentes fitofisionomias do...

  13. The study of rare B{sub c}→D{sub s,d}{sup (∗)}ll-macron decays

    Energy Technology Data Exchange (ETDEWEB)

    Ju, Wan-Li; Wang, Guo-Li [Department of Physics, Harbin Institute of Technology,Harbin, 150001 (China); Fu, Hui-Feng [Department of Physics, Tsinghua University,Beijing, 100084 (China); Wang, Tian-Hong; Jiang, Yue [Department of Physics, Harbin Institute of Technology,Harbin, 150001 (China)

    2014-04-09

    In this paper, we study rare decays B{sub c}→D{sub s,d}{sup (∗)}ll-macron within the Standard Model. The penguin, box, annihilation, color-favored cascade and color-suppressed cascade contributions are included. Based on our calculation, the annihilation and color-favored cascade diagrams play important roles in the differential branching fractions, forward-backward asymmetries, longitudinal polarizations of the final vector mesons and leptonic longitudinal polarization asymmetries. More importantly, color-favored cascade decays largely enhance the resonance cascade contributions. To avoid the resonance cascade contribution pollution, new cutting regions are put forward.

  14. Seletividade do Clomazone no Manejo Químico de Plantas Daninhas da Cultura do Algodão LL(r)

    OpenAIRE

    Arantes, J.G.Z.; Constantin, J.; Oliveira Jr., R.S.; Braz, G.B.P.; Takano, H.K.; Gemelli, A.; Oliveira Neto, A.M.; Brugnera, P.

    2015-01-01

    O amonio-glufosinate é um herbicida de amplo espectro de controle de plantas daninhas, porém não apresenta controle residual no solo, o que limita sua utilidade quando usado isoladamente na cultura do algodão, havendo a necessidade de combinar diferentes herbicidas em mais de uma modalidade de aplicação. O objetivo deste trabalho foi avaliar a seletividade de diferentes sistemas de controle químico de plantas daninhas contendo clomazone na cultura do algodão LL(r). As misturas triplas em pré-...

  15. treated rats

    African Journals Online (AJOL)

    aghomotsegin

    2014-01-08

    Jan 8, 2014 ... nucleus, bizarre segmentation; (I) shows hypersegmentation, bizarre segmentation of neutrophils in the shape of ring nucleus with polychromatophilic RBCs. 1998; Muller and Tobin, 1980). The current study shows that rats administered C. edulis hydro-ethanol extract, orally for 28 days, developed anemia, ...

  16. Quando o humor azeda: o episódio Rushdie em retrospectiva

    Directory of Open Access Journals (Sweden)

    Kanavillil Rajagopalan

    1996-08-01

    Full Text Available Este trabalho é uma tentativa de analisar retrospectivamente o episódio que envolve Salman Rushdie e seu romance Os versículos satânicos. Começo minha análise chamando atenção para o fato de que tanto o enredo da obra quanto o ambiente sócio-político-histórico em que ela aparece estão mergulhados no meio cultural da Índia de modo a não surpreender que o romance tenha se transformado numa questão tão explosiva no cenário internacional. Em seguida argumento que isso tudo nos ensina uma lição importante a respeito de leitura e interpretação. O que quer que Rushdie ou outra pessoa fizesse com o intuito de voltar atrás ou pedir clemência aos aiotolás enfurecidos, não havia como submeter o romance a uma re-leitura - a única interpretação final e definitiva já havia sindo impingida ao malfadado romance. Essa é a enrascada pós-moderna de Rushdie. A ironia - a mesma arma que ele tão habilmente havia utilizado não apenas nos Versículos satânicos mas também em seus romances anteriores - voltou-se contra ele, produzindo um inesperado efeito bumerangue. O que temos aqui é um caso de política da ironia em ação.This paper is an attempt to review in retrospect the episode involving Salman Rushdie and his novel The satanic verses. I begin my analysis by calling attention to the fact that both the plot of the novel and the socio-historico-political backdrop against which it is projected are so steeped in India's cultural milieu that it is indeed surprising that the novel became such an explosive issue on the international scenario. But then I argue that there is an important lesson to be learned from all this concerning reading and interpretation. No matter what Rushdie or anybody else could possibly have done by way of retracing the steps or pleading with Iran's enraged ayatollahs for clemency, there was no way his novel could have been subjected to a re-reading - the one final and definitive interpretation had already

  17. Infusion of exogenous cholecystokinin-8, gastrin releasing peptide-29 and their combination reduce body weight in diet-induced obese male rats.

    Science.gov (United States)

    Mhalhal, Thaer R; Washington, Martha C; Newman, Kayla; Heath, John C; Sayegh, Ayman I

    2017-02-01

    We hypothesized that exogenous gastrin releasing peptide-29 (GRP-29), cholecystokinin-8 (CCK-8) and their combination reduce body weight (BW). To test this hypothesis, BW was measured in four groups of diet-induced obese (DIO) male rats infused in the aorta (close to the junctions of the celiac and cranial mesenteric arteries) with saline, CCK-8 (0.5 nmol/kg), GRP-29 (0.5 nmol/kg) and CCK-8+GRP-29 (0.5 nmol/kg each) once daily for a total of 23 days. We found that CCK-8, GRP-29 and CCK-8+GRP-29 reduce BW relative to saline control. In conclusion, CCK-8, GRP-29 and their combination reduce BW in the DIO rat model. If infused near their gastrointestinal sites of action CCK-8, GRP-29 and their combination may have a role in regulating BW. Published by Elsevier Ltd.

  18. The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.

    Science.gov (United States)

    Mentuccia, Daniela; Thomas, Matthew J; Coppotelli, Giuseppe; Reinhart, Laurie J; Mitchell, Braxton D; Shuldiner, Alan R; Celi, Francesco S

    2005-11-01

    A common polymorphism of the type 2 deiodinase gene (Thr92Ala DIO2) was found to be associated with insulin resistance in a mixed Caucasian population. The aim of this study was to investigate the association of the Thr92Ala DIO2 variant to indices of insulin resistance in the Old Order Amish. A genotype-phenotype association study was performed at the research clinic in Strasburg, Pennsylvania, and the molecular genetics laboratory at the University of Maryland, Baltimore, Maryland, and the National Institutes of Health, Bethesda, Maryland. A total of 1,268 subjects participated in the Amish Family Diabetes Study. An association among the Thr92Ala DIO2 variant and type 2 diabetes, indices of insulin resistance (HOMA-IR), insulin secretion, free thyroid hormones, and thyrotropin (TSH) was found. No association was found among the Thr92Ala DIO2 variant and type 2 diabetes, impaired glucose tolerance, or body mass index (BMI) in the Amish. In nondiabetics (n = 747), the Ala92 allele tended to be associated with decreased rather then increased insulin secretion. No differences were observed in thyroid hormones or TSH. Contrary to prior findings, the Thr92Ala DIO2 variant tends to be associated with increased rather then decreased insulin sensitivity in the Amish. These findings could be secondary to a different genetic background or to environmental factors specific for this population.

  19. Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y

    Science.gov (United States)

    Brown, Michael; Bing, Chen; King, Peter; Pickavance, Lucy; Heal, David; Wilding, John

    2001-01-01

    We studied the effects of the novel noradrenaline and serotonin (5-HT) reuptake inhibitor sibutramine on feeding and body weight in a rat model of dietary obesity, and whether it interacts with hypothalamic neuropeptide Y (NPY) neurones.Chow-fed and dietary-obese (DIO) male Wistar rats were given sibutramine (3 mg kg−1 day−1 p.o.) or deionized water for 21 days.Sibutramine decreased food intake throughout the treatment period in both dietary-obese rats (Psibutramine-treated dietary-obese rats (Psibutramine treatment (Psibutramine compared to untreated controls.The hypophagic and anti-obesity effects of sibutramine in dietary-obese Wistar rats appear not to be mediated by inhibition of ARC NPY neurones. PMID:11309262

  20. Reorganização familiar e rede social de apoio pós-homicídio juvenil

    Directory of Open Access Journals (Sweden)

    Daniela Fontoura Domingues

    Full Text Available A morte violenta de jovens provoca mudanças no cotidiano das famílias e nas comunidades, particularmente nos modos de organização dos sobreviventes. Este estudo buscou investigar as transformações nos sentimentos, nas relações sociais e na rede social de apoio de oito famílias que perderam jovens vitimados por homicídio no Distrito Federal. Participaram da pesquisa mães e irmãos destes jovens, que responderam a um questionário de caracterização do sistema familiar e a uma entrevista semiestruturada. Os relatos, submetidos à análise qualitativa, apontaram sentimentos de desespero, dor, culpa, revolta e medo. O episódio alterou o funcionamento familiar, provocando desorganização nas relações conjugais e parentais. Os resultados indicam a necessidade de fortalecer a rede social dessas famílias e de investir em políticas públicas.

  1. Observações no infravermelho médio de objetos estelares jovens em NGC 3576

    Science.gov (United States)

    Barbosa, C.; Damineli, A.; Blum, R.; Conti, P.

    2003-08-01

    Apresentamos os resultados de observações no infravermelho médio de candidatos a objetos estelares jovens e massivos em NGC 3576. As imagens de alta resolução foram obtidas no observatório Gemini Sul com o uso dos filtros em 10,8, 7,9, 9,8, 12,5 e 18,2 mm. Nossas imagens mostram a fonte IRS 1 resolvida em 4 objetos pela primeira vez em 10 mm. Para cada objeto obtivemos a distribuição espectral de energia de 1.2 até 18 mm, bem como a temperatura de cor, a distribuição espacial e a profundidade óptica em 9,8 mm da poeira circunstelar. Apresentamos uma estimativa das massas dos objetos estudados, baseados na luminosidade emitida no infravermelho médio, bem como um modelo para explicar as diferentes características observadas de cada objeto. Finalmente discutimos a possível localização da(s) fonte(s) de ionização de NGC 3576.

  2. O suicídio Tikúna no Alto Solimões: uma expressão de conflitos

    Directory of Open Access Journals (Sweden)

    Regina M. de Carvalho Erthal

    Full Text Available O objetivo deste trabalho é buscar um entendimento a respeito da ocorrência de suicídios entre os índios Tikúna do Alto Solimões (Amazonas, um objeto de difícil aproximação e que aponta para a necessidade de abordagem interdisciplinar. A etnografia realizada preocupou-se em captar a vinculação entre os eventos de suicídio da última década com a exacerbação dos confrontos entre diferentes grupos faccionais que atualizam, em outro contexto histórico, os mecanismos de resolução de conflitos próprios das antigas malocas. Na base desses confrontos está o abandono a que tal população tem sido submetida pelos órgãos responsáveis pela definição e implementação das políticas públicas para as populações indígenas, com especial destaque para a falência do modelo de assistência proposto para a área do Alto Solimões.

  3. Tratamento da distrofia muscular progressiva com lactato de sódio Treatment of progressive muscular dystrophy with sodium lactate

    Directory of Open Access Journals (Sweden)

    José Antonio Levy

    1969-12-01

    Full Text Available Com base em trabalhos anteriores, 13 casos de distrofia muscular progressiva foram tratados com lactato de sódio 1/6 molar associado a ATP e complexo B. O exame da força muscular, realizado antes e após o tratamento — salvo em dois casos nos quais ocorreram melhoras muito discretas — não mostrou qualquer efeito favorável da medicação. Os autores sugerem a verificação de possíveis alterações enzimáticas provocadas pelo lactato de sódio, o que serviria para melhor avaliação do efeito terapêutico.Thirteen cases of progressive muscular dystrophy were treated with 1/6 M. sodium lactate plus ATP and B complex. Examinations of muscle strength, before and after the treatment, did not show any favourable effects, except in two of the cases which showed slight improvement. The authors suggest that possible enzimatic alterations caused by the sodium lactate be checked up on, since this checking could be employed in the evaluation of the therapeutic effects.

  4. Valproato de sódio: efeitos colaterais em crianças Valproate therapy: side effects in children

    Directory of Open Access Journals (Sweden)

    Marlene Pereira Garanito

    2009-12-01

    Full Text Available OBJETIVO: O valproato de sódio é um fármaco anticonvulsivante usado com frequência no manejo dos quadros epilépticos refratários na infância e habitualmente apresenta boas taxas de resposta e toxicidade aceitável. O objetivo deste artigo é destacar os efeitos colaterais secundários ao uso prolongado de valproato de sódio em uma criança e alertar para a importância do acompanhamento dos pacientes em uso crônico de anticonvulsivantes. DESCRIÇÃO DO CASO: Criança do sexo masculino, com quatro anos e oito meses, portadora de síndrome de West, em uso de valproato de sódio desde os seis meses de idade, admitida no hospital com anemia, macrocitose, plaquetopenia, deficiência de vitamina B12, hipoalbuminemia e hiponatremia. Durante a internação e o acompanhamento ambulatorial, relacionou-se o quadro clínico ao uso do valproato de sódio. COMENTÁRIOS: A toxicidade hematológica do valproato de sódio é bem conhecida e comum, podendo variar em relação à época de instalação e gravidade. Os achados mais frequentes são a plaquetopenia e a macrocitose. Além das alterações hematológicas, a literatura relata outros efeitos colaterais relacionados ao uso do fármaco. Destaca-se a importância do conhecimento e monitorização dos eventos adversos nos pacientes submetidos a esse tipo de terapia, para que eles possam ser detectados e tratados o mais precocemente.OBJECTIVE: Valproic acid is an anticonvulsant frequently used in the management of childhood refractory epilepsy with good clinical responses and acceptable toxicity. The objective of this case report is to describe side effects associated with long-term valproate therapy in a child and to warn about the importance of monitoring patients in chronic use of anticonvulsants. CASE DESCRIPTION: This male child, four years and eight months old, with West syndrome, had been using sodium valproate since six months of age. The patient was admitted with anemia, macrocytosis

  5. The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

    OpenAIRE

    Steiner, Michel A.; Sciarretta, Carla; Pasquali, Anne; Jenck, Francois

    2013-01-01

    The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditions. Here we investigated the effects of chronic treatment with the novel selective OXR-1 antagonist ACT-335827 in a rat model of diet-induced obesity (DIO) associated with metabolic syndrome (MetS...

  6. As notícias nos sites de rádio: contributos para a identidade da notícia ciber-radiofónica

    OpenAIRE

    Reis, Ana Isabel

    2013-01-01

    A construção da notícia na rádio e na internet é forçosamente diferente porque cada meio desenvolve a sua própria linguagem e expressividade. O conceito de notícia é o mesmo, a forma de a redigir e apresentar é que pode ser diferente. O online, tal como a rádio, tem as suas próprias regras de redação, mas quando a notícia de rádio vai para o site da respetiva estação não é meramente transposta nem se reformula por inteiro seguindo as normas ciberjornalísticas. Numa análise que compila exemplo...

  7. Conglomerados de homicídios e o tráfico de drogas em Belo Horizonte, Minas Gerais, Brasil, de 1995 a 1999

    Directory of Open Access Journals (Sweden)

    Cláudio Chaves Beato Filho

    Full Text Available Neste trabalho, apresentamos uma análise espacial dos homicídios ocorridos em Belo Horizonte e registrados pela Polícia Militar de Minas Gerais durante o período de 1995 até 1999. Utilizamos o programa SaTScan para identificar os conglomerados de risco de mortalidade mais elevado. Considerando todas as regiões da cidade de Belo Horizonte, apenas dez apresentam um risco maior de homicídios, quase todas concentradas em favelas. Como existem 85 favelas ao todo, concluímos que não são as condições sócio-econômicas per se as responsáveis pelos conglomerados de homicídios, mas o fato dessas regiões serem assoladas pelo trafico e violência associada ao comércio de drogas.

  8. Conglomerados de homicídios e o tráfico de drogas em Belo Horizonte, Minas Gerais, Brasil, de 1995 a 1999

    Directory of Open Access Journals (Sweden)

    Beato Filho Cláudio Chaves

    2001-01-01

    Full Text Available Neste trabalho, apresentamos uma análise espacial dos homicídios ocorridos em Belo Horizonte e registrados pela Polícia Militar de Minas Gerais durante o período de 1995 até 1999. Utilizamos o programa SaTScan para identificar os conglomerados de risco de mortalidade mais elevado. Considerando todas as regiões da cidade de Belo Horizonte, apenas dez apresentam um risco maior de homicídios, quase todas concentradas em favelas. Como existem 85 favelas ao todo, concluímos que não são as condições sócio-econômicas per se as responsáveis pelos conglomerados de homicídios, mas o fato dessas regiões serem assoladas pelo trafico e violência associada ao comércio de drogas.

  9. Análises proteômicas de conídios do fungo patogênico humano Paracoccidioides sp

    OpenAIRE

    Moreira, André Luís Elias

    2014-01-01

    A paracoccidioidomicose (PCM) é uma micose sistêmica causada pelo fungo termodimórfico Paracoccidioides spp.. A principal rota de infecção da PCM ocorre por inalação de conídios ou fragmentos de micélio. Até o momento, estudos proteômicos não foram realizados com conídios de Paracoccidoides sp. Neste sentido, caracterizar o proteoma do conídio poderá contribuir para o conhecimento detalhado das proteínas expressas durante a fase de propagação e seus potenciais papéis na virulência e patogenic...

  10. Quando o trabalho não dignifica as relações humanas: Um estudo sobre o assédio moral na Universidade Federal de Pernambuco

    OpenAIRE

    Souza, Carla Neres; Barros, Natália Conceição Silva

    2015-01-01

    O presente artigo pretende expor uma análise das relações humanas no ambiente de trabalho com ênfase nas situações de assédio moral. A princípio apresentamos uma definição de assédio moral sob a ótica dos direitos humanos nos detendo principalmente nos princípios da dignidade humana. O artigo concentra-se especificamente nas situações de assédio moral que ocorrem nas relações de trabalho das instituições públicas teorizando sobre suas concepções, características e conseqüências. Ao final é ap...

  11. Da deterioração das relações à escolha pela permanência: O assédio moral no trabalho.

    Directory of Open Access Journals (Sweden)

    Victor Vieira Silva

    2016-08-01

    Full Text Available O artigo tem como objetivo conhecer e compreender os motivos pelos quais as pessoas que sofreram assédio moral continuam na organização. O assédio moral é um fenômeno intimamente relacionado ao ambiente em que ocorre. As organizações fazem e reproduzem um contexto onde a competitividade é necessária para se atingir os objetivos organizacionais, o que legitima qualquer comportamento que se tenha em busca desses. A análise dos resultados mostrou que os principais motivos que levam a permanência em um trabalho onde se sofre assédio moral relacionam-se ao contexto do trabalho, que possibilitam a satisfação de necessidades básicas dos indivíduos.

  12. Desigualdades na mortalidade por suicídio entre indígenas e não indígenas no estado do Amazonas, Brasil

    OpenAIRE

    Souza, Maximiliano Loiola Ponte de; Orellana, Jesem Douglas Yamall

    2013-01-01

    OBJETIVO: Analisar as taxas e algumas características da mortalidade por suicídio entre indígenas e não indígenas no Amazonas. MÉTODO: Estudo de coorte retrospectiva, em que os dados de óbito foram obtidos no Sistema de Informações sobre Mortalidade e os populacionais no Instituto Brasileiro de Geografia e Estatística. Foram utilizados todos os registros de suicídio do período de 2006-2010 e a interpolação geométrica anual para a estimação das subpopulações. RESULTADOS: Ocorreram 688 suicídio...

  13. QUALIDADE PÓS-COLHEITA DE MORANGOS CV. ‘DIAMANTE’ TRATADOS COM CLORETO DE CÁLCIO ASSOCIADO A HIPOCLORITO DE SÓDIO

    OpenAIRE

    Leandro de Morais CARDOSO; Vânia Amorim de DEUS; Enilson de Barros SILVA; Valter Carvalho de ANDRADE JÚNIOR; Nísia Andrade Villela DESSIMONI-PINTO

    2012-01-01

    O objetivo desse trabalho foi estudar os efeitos da aplicação do cloreto de cálcio associado ao hipoclorito de sódio na qualidade pós-colheita de morangos cv. Diamante. Os frutos foram coletados, selecionados e submetidos à imersão em: 1 - água destilada (controle), 2 - hipoclorito de sódio a 2% e 3 - hipoclorito de sódio (2%) + Cloreto de cálcio (1%). Em seguida foram divididos em 2 lotes, um mantido à temperatura ambiente (20,5 ± 3ºC e 59% a 66% de UR) e outro sob re...

  14. Prevenção e combate ao assédio moral entre servidores públicos do estado do Ceará

    Directory of Open Access Journals (Sweden)

    Rachel de Aquino Câmara

    Full Text Available O assédio moral, violência moral ou psicoterrorismo no trabalho é um tema que vem sendo bastante discutido nas últimas décadas, incorporando-se aos estudos na área de saúde do trabalhador. A fim de incentivar estudos sobre o conceito e favorecer a prevenção e o combate de tal fenômeno entre os servidores públicos do Ceará, bem como proporcionar condições de trabalho favoráveis à saúde do trabalhador, foi instituido em 2009 um projeto de prevenção e combate ao assédio moral na administração pública executiva do estado. Este artigo relata a instalação da primeira Comissão Setorial de Combate ao Assédio Moral no Trabalho, do treinamento desta para intervir em situações de assédio e da avaliação do processo de capacitação e sua adequação à proposta do projeto. O treinamento do grupo constituiu de reuniões quinzenais durante cinco meses e com visitas em algumas unidades de uma das secretarias do estado. Para a avaliação desse processo foram realizadas entrevistas semiestruturadas com os integrantes, após o treinamento, em 2010. Apesar dos resultados mostrarem que o grupo teve algumas dificuldades de envolvimento com a proposta, eles apresentaram um maior discernimento acerca do que é ou não um caso fidedigno de assédio moral e acerca da postura a ser adotada nos casos de assédio.

  15. ESTÁDIOS DE DESENVOLVIMENTO DE EMBRIÕES NA OBTENÇÃO DE PLANTAS EM CRUZAMENTOS ENTRE GENITORES APIRENOS DE VIDEIRA

    Directory of Open Access Journals (Sweden)

    AMARAL ADRIANE LEITE DO

    2001-01-01

    Full Text Available Pesquisou-se o efeito do estádio de desenvolvimento de embriões resgatados na obtenção de plantas em cruzamentos entre genitores apirenos de videira, utilizando dois métodos de cultivo in vitro de sementes-traço. No método 1 (M1, as sementes-traço foram cultivadas 60 dias em meio-de-cultura ER e no método 2 (M2 60 dias em ER, mais 30 dias em meio-de-cultura MS. O estádio de desenvolvimento do embrião foi identificado no final destes períodos, quando do resgate e transferência para meio-de-cultura WP. Quatro tipos de embriões foram identificados: globular, cordiforme, torpedo e indefinido. O estádio globular foi encontrado com maior freqüência, levando à obtenção de maior número de plantas, mesmo tendo apresentado menor capacidade de gerar plantas. A maior eficiência em gerar plantas foi obtida com o estádio torpedo. No M2, ocorreu maior número de embriões germinados e de plantas desenvolvidas. Como o estádio de desenvolvimento do embrião influencia na obtenção de plantas, o resgate de embriões em estádio mais avançado do seu desenvolvimento leva a tem maior capacidade de gerar plantas. Portanto, uso de técnicas que favoreçam o resgate de embriões mais desenvolvidos pode aumentar o número de plantas obtidas.

  16. Angular analysis of B→K"*ll and search for B"+→K"+ττ at the BELLE experiment

    International Nuclear Information System (INIS)

    Wehle, Simon

    2016-09-01

    Rare decays of B mesons are an ideal probe to search for phenomena beyond the Standard Model of particle physics, since contributions from new particles can affect the decays on the same level as Standard Model predictions. The rare decay of B→K"("*")l"+l"- offers the quark transition b→sl"+l"-, a flavor changing neutral current which is forbidden at tree level in the Standard Model. Higher order processes such as penguin or W"+W"- box diagrams allow for these processes, leading to branching ratios of less than one in a million. Various extensions to the Standard Model predict influences of new physics, which can enhance or suppress branching ratios or lead to changes in angular distributions of the decay products. In order to produce a sufficient amount of B mesons, the so-called B-factories were designed. One of them is the asymmetric-energy e"+e"- collider KEKB with the Belle experiment, located in Tsukuba, Japan. During 1999 to 2010 the experiment recorded a total luminosity of 1 ab"-"1 of electron positron collisions. In this thesis a comprehensive study of the flavor changing neutral current process b→sl"+l"- in B meson decays with accompanying kaons is presented in two separate analyses. All three lepton modes, e"+e"-, μ"+μ"- and τ"+τ"- are investigated to search for evidence of physics beyond the Standard Model. The measurements are performed using the full Belle data sample of 772 x 10"6 B anti B pairs, recorded at the Υ(4S) resonance energy. The first analysis in this thesis covers the muon and electron modes in the decay of B"0→K"*(892)"0l"+l"-. To maximize signal efficiency and purity, neural networks are developed sequentially from the bottom to the top of the decay chain, transferring each time the output probability to the subsequent step such that most effective selection cuts are applied in the last stage based on all information combined. Reconstructed signal yields of both channels exceed previous B-factory results of Belle and Ba

  17. Mortalidade por homicídios no Brasil na década de 90: o papel das armas de fogo

    Directory of Open Access Journals (Sweden)

    Peres Maria Fernanda Tourinho

    2005-01-01

    Full Text Available OBJETIVO: Descrever a evolução da mortalidade por homicídio no Brasil, na década de 1990, buscando analisar a contribuição das armas de fogo. MÉTODOS: Estudo ecológico descritivo de série temporal para o período 1991 a 2000. Dados sobre óbitos por causas externas, segundo local de residência, foram obtidos para a população total e grupos de sexo. A fonte de dados utilizada foi o Sistema de Informação sobre Mortalidade do Ministério da Saúde (SIM/Datasus. Os homicídios foram classificados em homicídios por armas de fogo, por outros instrumentos e por meios não especificados. Foram calculados a mortalidade proporcional e os coeficientes de mortalidade (/100.000 habitantes. RESULTADOS: Os homicídios foram responsáveis por 33% dos óbitos por causas externas na década de 1990. As armas de fogo contribuíram com mais de 50% dos casos já em 1991, e com cerca de 70% no ano 2000. Esse crescimento ocorreu em ambos os grupos de sexo e em todas as capitais. O coeficiente de mortalidade por homicídio cresceu 27,5%, sendo que o incremento nos homicídios cometidos com armas de fogo foi de 72,5%. No período houve uma queda nos casos decorrentes de instrumentos não especificados, o que pode explicar parte do incremento observado para os homicídios com armas de fogo. CONCLUSÕES: Os dados indicam significativa contribuição das armas de fogo para o crescimento dos homicídios na década de 1990. Problemas na qualidade das informações, tanto no que se refere às mortes com intencionalidade indeterminada como ao tipo de instrumento utilizado, prejudicaram a análise dos dados.

  18. Viscosidade extensional e em cisalhamento de suspensões acidificadas de amido de amaranto e caseinato de sódio

    OpenAIRE

    Gozzo,Angela Maria; Cunha,Rosiane Lopes; Menegalli,Florencia Cecília

    2009-01-01

    Foram avaliadas as viscosidades extensional e em cisalhamento de suspensões acidificadas de amido de amaranto-caseinato de sódio. Sistemas mistos de amido de amaranto-caseinato de sódio acidificados com glucona-delta-lactona (GDL) foram estudados por ensaios reológicos em compressão biaxial e cisalhamento. Os efeitos da velocidade de acidificação (lenta e rápida) e pH final (neutro e no ponto isoelétrico da caseína) foram avaliados considerando as interações entre os biopolímeros e sua conseq...

  19. A influência da cultura organizacional na ocorrência do assédio moral no trabalho na Universidade Federal de Santa Catarina

    OpenAIRE

    Nunes, Thiago Soares

    2016-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico, Programa de Pós-Graduação em Administração, Florianópolis, 2016. Um dos ambientes mais afetados pelo assédio moral é o setor da educação, especialmente em decorrência de disputas de poder, usualmente como elemento constituinte da cultura. Embora a cultura influencie e/ou sustente práticas de assédio moral, a literatura e as pesquisas não apresentam como e quais elementos culturais propiciam a ocorrência da v...

  20. Sistema integrado de asuntos académicos de la Universidad Nacional Amazónica de Madre de Dios - Puerto Maldonado (SIAA-UNAMAD)

    OpenAIRE

    Canahuire Cruz, Genaro

    2007-01-01

    El trabajo de investigación intitulado "SISTEMA INTEGRADO DE ASUNTOS ACADÉMICOS DE LA UNIVERSIDAD NACIONAL AMAZONICA DE MADRE DE DIOS (SIAA-UNAMAD)", se a desarrollado en la Universidad Nacional Amazónica de Madre de Dios durante los años 2006 y 2007, dando solución a un conjunto de problemas que aquejaban en el servicio a los Estudiantes, Docentes y Administrativos de la Universidad. Los sistemas de información se aplican en diversas áreas donde se maneJan registros de informaciones y las Ba...

  1. Mortes por suicídio: diferenças de gênero e nível socioeconômico

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    Leticia Marín-León

    2003-06-01

    Full Text Available OBJETIVO: Descrever a tendência da mortalidade por suicídio e o perfil sociodemográfico, identificando diferenças de sexo e nível socioeconômico. MÉTODOS: Analisou-se a tendência das taxas brutas de suicídio, em Campinas, SP, no período 1976-2001, segundo o sexo. Para a análise sociodemográfica dos óbitos, no período de 1996-2001, foi utilizado o Banco de Dados de Óbitos de Campinas. Para a análise das diferenças socioeconômicas utilizou-se abordagem ecológica, em que as 42 áreas de abrangência das unidades básicas dos serviços de saúde foram agrupadas em quatro estratos homogêneos. Calcularam-se taxas padronizadas por idade (método direto. RESULTADOS: Comparando a outros países, a mortalidade por suicídio no município foi baixa (<5 ób/100.000 hab. A sobremortalidade masculina foi superior a 2,7 suicídios masculinos para cada suicídio feminino. Em 1980-1985 as maiores taxas foram observadas nos adultos de 55 anos e mais; já em 1997-2001 as taxas são mais elevadas nos adultos de 35-54 anos. Entre os homens, os meios mais utilizados são o enforcamento (36,4% e as armas de fogo (31,8%. Entre as mulheres predomina o envenenamento (24,2%, seguido pelas armas de fogo e enforcamento (21,2% cada; este último ocorreu predominantemente no domicílio (75,7%; já as mortes por arma de fogo e envenenamento ocorreram em maior proporção em hospitais. Diferentemente dos homicídios, os suicídios não apresentam aumento progressivo das taxas com a diminuição do nível socioeconômico. CONCLUSÕES: As taxas são baixas, oscilando com aumentos e declínios sucessivos, sem tendência continua de crescimento ou redução. Os riscos de morte por suicídio são maiores nos homens e não aumentam com a redução do nível socioeconômico.

  2. Redesenhando o curr?culo do ensino m?dio: O caso do ProEMI na escola Educand?rio Oliveira Brito - Euclides da Cunha/BA

    OpenAIRE

    Machado, Anny Karine Matias Novaes

    2016-01-01

    Historicamente o Ensino M?dio se constituiu como o n?vel de maior complexidade na elabora??o de pol?ticas p?blicas. Sendo marcado por um longo processo de indefini??o identit?ria, cujas oscila??es abarcavam um modelo proped?utico com destino ? continua??o de estudos em n?vel superior e um profissional direcionado ?s classes trabalhadoras. Atualmente, as pol?ticas de reformula??o do Ensino M?dio tomam o curr?culo como foco de mudan?a e buscam superar essa dualidade estrutural (KUENZER, 2010) a...

  3. Ideações e tentativas de suicídio em adolescentes com práticas sexuais hetero e homoeróticas

    OpenAIRE

    Teixeira-Filho,Fernando Silva; Rondini,Carina Alexandra

    2012-01-01

    Esta pesquisa, que teve como população-alvo adolescentes com idade entre 12 e 20 anos, residentes em três municípios do interior Paulista, buscou conhecer as associações entre orientação sexual e ideações e tentativas de suicídio. Corroborando com as pesquisas internacionais, evidenciou-se que os não heterossexuais têm mais chances de pensarem e tentarem suicídio, comparativamente aos heterossexuais. Todavia, encontrou-se que, dentre o grupo de adolescentes que se assumiram não heterossexuais...

  4. Gonçalves, António Custódio: A história revisitada do Kongo e de Angola. Lisboa: Editorial Estampa, 2005

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    Rosana Gonçalves

    2006-12-01

    Full Text Available Antônio Custódio Gonçalves é sociólogo e professor catedrático de Geografia da Universidade do Porto, onde dirige o Centro de Estudos Africanos (CEAUP, coordenando um importante periódico sobre África, a Africana Studia. Há anos debruçado sobre temáticas africanas, António Custódio Gonçalves sintetiza muitas das complexas questões sobre a história do Kongo e Angola nesta publicação.

  5. ACETURATO DE DIMINAZENO ASSOCIADO AO SELENITO DE SÓDIO E A VITAMINA E: TESTES IN VITRO E EM RATOS EXPERIMENTALMENTE INFECTADOS COM Trypanosoma evansi

    OpenAIRE

    Alexandre Alberto Tonin

    2012-01-01

    O objetivo deste estudo foi avaliar a utilização de um tratamento padrão contra a infecção causada pelo T. evansi, baseado na utilização do aceturato de diminazeno associado ao selenito de sódio e a vitamina E. Os testes in vitro mostraram um efeito tripanocida relacionados ao tratamento com aceturato de diminazeno e selenito de sódio; contudo a vitamina E não gerou nenhum efeito nocivo sobre o tripanossomas. Experimentos in vivo utilizaram um total de 72 fêmeas adultas de rato...

  6. Assédios sexual e moral no trabalho Um estudo acerca da legislação no Brasil

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    Andréia da Cruz

    2012-11-01

    Full Text Available O presente artigo apresenta resultados de pesquisa realizada em 2009/2010 sobre os processos de formulação e aprovação da legislações brasileiras que dispõem sobre os assédios sexual e moral. Visamos identificar os fatores que foram fundamentais nesses processos, levantandose como hipótese a seguinte: As denúncias de vítimas de assédio sexual e de assédio moral foram fundamentais para o surgimento dessa nova legislação. Com o intuito de investigar a procedência dessa hipótese foram aplicadas as seguintes técnicas de pesquisa: 1 análise documental, e 2 sete entrevistas semi-estruturadas com questões abertas a pessoas que trabalham nessa área e/ou acompanharam as discussões sobre a referida legislação. Constatou-se com este estudo que diversidade de fatores contribuíram para o surgimento da legislação específica, para além das denúncias, especialmente a participação dos movimentos sociais, do movimento feminista e do movimento de mulheres. English: The current article presents the research results about the formulation and approval process of the Law that disposes about the sexual and moral harassment in Brazil. It was the objective identifying the factors that were fundamental during the process, whose hypothesis was: the complaints from victims of sexual and moral harassment were fundamental to the emergence of the legislation. In order to investigate the validity of this hypothesis, we applied the following research techniques: 1 document analysis, and 2 seven semi-structured interviews with open questions to people working in this area and/or followed the discussions about this legislation. It was found from this study that several factors contributed to the emergence of specific legislation, in addition to complaints, especially the participation of social movements, the feminist movement and the women's movement.

  7. La enfermería de la Orden de San Juan de Dios en el Chile colonial

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    Julia Cristobalina Huaiquián-Silva

    2013-01-01

    Full Text Available Objetivo: describir las prácticas de enfermería en Chile durante la época colonial, prestando especial atención a la influencia de España en dicho proceso. Método: investigación cualitativa de abordaje socio-histórico; las fuentes primarias corresponden a textos históricos de Chile recuperados en la Biblioteca Virtual Memoria Chilena, y a 34 documentos recopilados en el Archivo Museo San Juan de Dios, Casa de los Pisa, en Granada, España, titulados “Listado de los hermanos de San Juan de Dios que vivían en Chile (207 años y un índice de documentos inéditos copiados de los archivos histórico nacional y del antiguo hospital, por Faustino Calvo”. La recolección de la información se efectuó con ficha documental confeccionada por la investigadora, complementada con fotografías. El análisis de los datos se realizó a través de análisis de contenido. Resultados: la Orden de San Juan de Dios llegó a Chile en el año 1617 a los hospitales de Santiago y Concepción y se expandió a las ciudades de La Serena, Valparaíso, San Juan de la Frontera, Talca, Chillan, Concepción y Valdivia. Por más de doscientos años la Orden permaneció en Chile brindando asistencia hospitalaria y de enfermería a través de los cuidados religiosos. Conclusión: con la llegada de la Orden al país mejoró indiscutiblemente la organización de los cuidados de salud al interior de los hospitales, que a partir de esa fecha se administraron de forma organizada, con altos estándares de higiene y limpieza, vigilando sigilosamente la alimentación de sus pacientes y con una gran preocupación por brindar asistencia espiritual a quienes necesitasen de sus servicios.

  8. A ordem regional no Oriente Médio 15 anos após os atentados de 11 de Setembro

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    Danny Zahreddine

    2015-03-01

    Full Text Available O artigo aborda a ordem regional do Oriente Médio 15 anos após os atentados de 11 de setembro de 2001, analisando a relevância das potências regionais para o equilíbrio de poder naquela região. A pergunta a ser respondida é se os atentados de 11 de setembro alteraram de maneira significativa a ordem regional. O objetivo da pesquisa é avaliar o papel das potências regionais para as relações de poder no Oriente Médio e suas transformações após os atentados. Para tanto, serão apresentados os conceitos de poder, ordem e potência regional, bem como uma breve descrição das transformações ocorridas nas relações internacionais do Oriente Médio desde as independências locais até o pós-11 de Setembro. Para categorizar os Estados como potência média, emergente ou regional será utilizado a perspectiva teórica tratada por Nolte (2010, Jordaan (2010 e Huelsz (2009. Para avaliar a distribuição de poder entre os principais atores estatais, bem como sua hierarquia de poder, utiliza-se os conceitos de poder real, potencial e ideacional. São aplicadas técnicas como a Análise de Componentes Principais (ACP, para analisar os períodos de 1980, 1990, 2001 (ano dos atentados e 2011 (dados mais recentes das fontes consultadas. Os resultados demonstram que as principais forças regionais que historicamente atuaram na região continuam presentes, e que a ordem regional vigente é semelhante à do início da década de 1990, sendo que as principais transformações se deram no campo ideacional em função do aumento da ação de forças transnacionais.

  9. Historia e impacto de la literatura científica del Departamento de Madre de Dios, Perú

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    Nigel C. A. Pitman

    2008-12-01

    Full Text Available Los libros, artículos, documentos gubernamentales y otros registros escritos de la biología y conservación de los trópicos llegan a solo una pequeña fracción de sus lectores potenciales. Algunos de los textos son inaccesibles debido al idioma en que están escritos. Otros sólo están disponibles a subscriptores de revistas caras del mundo desarrollado, o circulan exclusivamente en los países tropicales. Para entender mejor esta ineficiencia en la literatura científica tropical y lo que pueda significar para la conservación, realizamos una recopilación bibliográfica de las obras relacionadas a biología y conservación del departamento amazónico de Madre de Dios, Perú. El esfuerzo dio como resultado una lista de 2.202 textos escritos entre 1537 y 2004, sumando aproximadamente 80.000 páginas. El 93% de estos textos fueron escritos a partir de 1970. En 2004 la tasa de publicación había alcanzado casi tres textos por semana. Aproximadamente la mitad de la bibliografía de Madre de Dios es representada por textos en español escritos por autores peruanos y difíciles de conseguir fuera del Perú; la mayoría del resto son textos escritos en inglés por autores extranjeros y difíciles de conseguir en el Perú. Los autores extranjeros tienden a escribir acerca de estudios ecológicos con poca relevancia a los retos inmediatos de la conservación, mientras los autores peruanos hacen con mayor frecuencia recomendaciones prácticas para el manejo. En la lista de temas más tratados por estos textos, el uso sostenible de recursos naturales figura en tercer lugar, después de la ecología y el comportamiento animal. Se concluye el documento con algunas recomendaciones para convertir a la literatura tropical en un recurso más abierto y eficiente.

  10. Mídia Rádio Escola: contribuições para a leitura e escrita nos anos iniciais

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    Ana Cláudia Pavão Siluk

    2018-05-01

    Full Text Available Considering the complexity of both the reading and the writing process on elementary school and the immense technological apparatus available nowadays, the insertion of Media on the school environment seems essential for the pedagogical work. This study arises from the urgency of an investment on students´ reading and writing, especially on the early years, pointed by the National Evaluation of Literacy. Therefore, the main goal is to verify which the main contributions are regarding radio school media for elementary school students´ reading and writing. Through the action research and the methodological delineation adopted, data were produced by the participant observation which point radio school media as a technology through which the students can have the opportunity to build relevant knowledge regarding their level of education, especially on the reading and writing areas. The activities were developed with a fourth grade class from a public school in the south of Brazil. The results also show reach of other learning dimensions provided by the radio school integration on early years in five fundamental items: teamwork, research, reading, writing and program hearing. In this way, the study innovates when relating the National Evaluation of Literacy, radio school media and the development of students´ reading and writing. Considerando a complexidade do processo de leitura e escrita no ensino fundamental e o vasto instrumental tecnológico disponível hoje para o trabalho pedagógico, a inserção das mídias no ambiente escolar parece essencial. Esse estudo parte da urgência de um investimento na leitura e escrita dos estudantes, especialmente nos anos iniciais, apontado pela Avaliação Nacional de Alfabetização (ANA. Portanto, tem como objetivo verificar quais as contribuições da mídia rádio escola para a leitura e escrita dos estudantes do ensino fundamental. A partir da pesquisa-ação, delineamento metodológico adotado, foram

  11. Sonoras Cenas Escolares: histórias sobre educação, rádio e humor

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    Maria Angela Borges Salvadori

    2012-01-01

    Full Text Available Este artigo, escrito a partir do levantamento de registros sonoros e fontes impressas das décadas de 1930, 1940 e 1950, interroga sobre o sucesso de antigos programas radiofônicos de humor centrados em temáticas escolares, geralmente constituídos por diálogos entre um professor e seus alunos. Procura, neste sentido, analisar as tensões presentes entre conhecimento escolar, educação formal e programação das emissoras em um período no qual o rádio, antes saudado como veículo de educação nacional, foi tomado por aspectos comerciais e populares. Neste percurso, dialoga particularmente com os conceitos de linguagem e costume, construídos respectivamente por Mikhail Bakhtin e E. P. Thompson.

  12. La ira de Dios: sobre ‘Relatos salvajes’ de Damián Szifrón

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    Gonzalo Aguilar

    2017-12-01

    Full Text Available “La ira de Dios (sobre ‘Relatos salvajes’ de Damián Szifrón” propone un debate sobre una de las películas argentinas más exitosas de todos los tiempos. En polémica con las lecturas que señalaban y cuestionaban el carácter prepolítico del film y su uso de las pasiones más bajas del público, este ensayo busca otro camino: por un lado, analizar la ira como uno de los capitales políticos más importantes y decisivos de la sociedad contemporánea. Por otro, investigar los vínculos entre la película Relatos salvajes y la pospolítica en la sociedad del espectáculo.

  13. Los recursos de la poesía histórica: Dios trajo la sombra de Jorge Enrique Adoum

    OpenAIRE

    Gómez Soriano, Miguel Ángel

    2018-01-01

    Se plantea un acercamiento a los recursos característicos del género poético para el tratamiento de temáticas históricas a partir del poemario Dios trajo la sombra del ecuatoriano Jorge Enrique Adoum. A través del análisis de estos versos, el trabajo trata de desentrañar de qué manera algunas características de la poesía hispanoamericana de los años 50 y 60 del siglo XX popularizadas por la poética coloquial tienen una determinada utilidad para la relectura poética de la historia. De esta man...

  14. TEMPO DE TELA, PERCEPÇÃO DA QUALIDADE DE SONO E EPISÓDIOS DE PARASSONIA EM ADOLESCENTES

    OpenAIRE

    Silva, Alison Oliveira da; Oliveira, Luciano Machado Ferreira Tenório de; Santos, Marcos André Moura dos; Tassitano, Rafael Miranda

    2017-01-01

    RESUMO Introdução: O sono é um importante componente no processo de desenvolvimento biológico e mental das crianças e dos adolescentes, considerado fonte de revitalização das funções orgânicas. Objetivo: Analisar a associação entre o tipo e tempo de exposição à tela, a percepção da qualidade de sono e os episódios de parassonia em adolescentes. Métodos: Estudo transversal que incorpora um levantamento epidemiológico de base escolar com amostra representativa (n = 481) de estudantes (14 a 1...

  15. Percepções docentes sobre violência institucional escolar e assédio moral horizontal

    OpenAIRE

    Márques, Fernanda Telles; Assunção, Fernanda Oliveira Franco

    2015-01-01

    Voltado à questão da violência escolar, o artigo propõe a discussão da relação entre violência institucional e assédio moral horizontal ocorrido no exercício da docência. A pesquisa foi realizada em uma escola pública do ensino fundamental e tem, por objetivo, desvelar e discutir as percepções de professores sobre o perfil de agressores e vítimas enredados nas tramas das manifestações de violência abordadas. Para alcançar este objetivo, optou-se por fazer uso da Triangulação (DENZIN, 1989), e...

  16. A origem do universo como tema para discutir a Natureza da Ciência no Ensino Médio

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    Gustavo Antonio Montenegro Guttmann

    2015-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2015v32n2p442 Nesse artigo, será apresentada uma proposta de introdução de questões relativas à Natureza da Ciência a partir da confrontação de duas teorias distintas sobre a origem do universo. Esse trabalho foi desenvolvido junto a turmas de Ensino Médio de uma escola do Rio de Janeiro. As teorias são divergentes, sendo uma defensora de um universo com uma origem definida, o Big Bang, e a outra de um Universo Eterno. Ao final do trabalho, foi possível aferir que os alunos passaram a ter uma visão mais complexa sobre Ciência.

  17. A filosofia no ensino médio: a prática na sala de aula

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    Angeluce Comoretto Parcianello

    2017-02-01

    Full Text Available Este trabalho tem por objetivo delinear a filosofia no ensino médio: a prática na sala de aula com conteúdos propostos pela escola. Essa prática ocorreu numa escola do perímetro urbano no centro de uma cidade situada no Rio Grande do Sul, no ano de 2001. As aulas foram ministradas para adolescentes entre 14 e 19 anos idade. Procuramos envolver o aluno ao máximo para que ele próprio se sentisse instigado para discutir os assuntos propostos na sala de aula, com metodologia e análise da avaliação e prática docente.

  18. Interobserver reproducibility of the histological diagnosis of cervical dysplasia, Hospital San Juan de Dios, from January to December 2010

    International Nuclear Information System (INIS)

    Morales Navarro, Karla Andrea

    2013-01-01

    The reproducibility of the histological diagnosis of cervix specimens processed by the Pathology Service of the San Juan de Dios Hospital from January to December 2010 was determined. When operational failures were detected, possible improvement processes were proposed, guided by the study's findings. A moderate concordance for the Bethesda System and poor to moderate for the classification of Cervical Intraepithelial Neoplasia, was obtained after analyzing the diagnoses issued by the observers when comparing the pairs of pathologists. The concordance was moderate when comparing each pathologist with the standard for both classifications. The correlation was excellent when comparing the Classification Cervical Intraepithelial Neoplasia versus the Bethesda System. The categories with highest concordance were high-grade intraepithelial lesion and cervical intraepithelial neoplasia 3 and minor agreement were low-grade intraepithelial lesion and cervical intraepithelial neoplasia 2. The results agree and in some cases the results exceed the reproduction noted in the literature world medical [es

  19. A reforma do ensino médio nos anos de 1990: o parto da montanha e as novas perspectivas

    OpenAIRE

    Zibas, Dagmar M. L.

    2005-01-01

    O artigo descreve algumas injunções sociais, econômicas e pedagógicas que, ao final dos anos de 1990, estavam exigindo uma reforma curricular do ensino médio. Faz um levantamento da repercussão, na academia, dos documentos do Conselho Nacional de Educação que veicularam a reforma de 1998. Discute os dados de três pesquisas que acompanharam ou fizeram uma avaliação inicial da interação entre a reforma e as escolas, apontando indícios quanto à falta de condições mínimas necessárias para a conse...

  20. Qualidade de fruto da aceroleira cv. Olivier em dois estádios de maturação

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    Elisa Adriano

    2011-10-01

    Full Text Available A acerola é um fruto de grande potencial econômico e nutricional devido ao seu alto teor de vitamina C, destacando-se como alimento funcional. É comercializada principalmente na forma de polpa congelada e fruto in natura. O objetivo deste estudo foi avaliar a qualidade dos frutos da aceroleira cv. Olivier em dois estádios de maturação. Para tanto, foram colhidas amostras de frutos em um pomar comercial no município de Junqueirópolis-SP. Foram realizadas a determinação da cor externa dos frutos e análises das características químicas de teor de sólidos solúveis, pH, acidez titulável, açúcares redutores, 'ratio' e ácido ascórbico de frutos semi-maduros e maduros. Os resultados obtidos permitiram concluir que os frutos semimaduros apresentaram maior acidez total, menor teor de sólidos solúveis e menor concentração de açúcares; no entanto, estes frutos apresentaram maiores teores de vitamina C, expressa em ácido ascórbico. Portanto, quando se buscam altos índices de vitamina C, os frutos devem ser colhidos num estádio de maturação menos avançado, com coloração alaranjada. O estudo demonstrou também que a cv Olivier produz frutos com características adequadas tanto para o mercado in natura quanto para a indústria, apresentando boa coloração e características químicas dentro dos padrões para esta fruta.

  1. Wolfhart Pannenberg y el reto de la Modernidad: Pensar a Dios y al hombre desde la mediación

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    Carlos Casale Rolle

    2006-01-01

    Full Text Available Este artículo pretende analizar la obra de Pannenberg como teología de la mediación, cuya característica básica radica en aceptar el órdago lanzado por el ateísmo moderno (sobre todo de la hermenéutica de la sospecha, partiendo de los mismos presupuestos de este: la antropología. Por eso el centro de interés de la teología de este autor radica en mediar racionalmente fe y razón o, si se quiere, teología y antropología. El objetivo de este intento es hacer razonable la idea misma de Dios, como el poder que todo lo determina, para que la revelación de Dios en las religiones, y en especial la cristiana, que es el lugar donde se decide sobre la realidad de la divinidad, cuente con un ámbito de inserción al interior de las preguntas fundamentales del hombre. Se pretende así hacer una teología con identidad y relevanciaThe article analyses Pannenberg's work, as a theology of mediation, whose basic principle lies on the acknowledgment of the havoc caused by the modern atheism (mainly by the hermeneutics of suspicion, looking at it from its very underpinning: the anthropology. The centre of attention of his theological thought lies on a rational mediation of faith and reason, or rather theology and anthroposophy. He pursues to make the idea of God as the determining power reasonable for us, so that God's revelation in the religions, and especially in the Christian that is where the reality of his divinity is decided, may find a place for insertion in the fundamental human questions. Accordingly, he attempts to develop a theology with identity and relevance

  2. Letramento e identidade: o que revelam os textos de alunos egressos do ensino fundamental e médio?

    Directory of Open Access Journals (Sweden)

    Ademar da Silva

    2012-06-01

    Full Text Available Atualmente os textos escritos de muitos alunosegressos do ensino fundamental e médio chamam atenção pela forte marca da oralidade e pela ocorrência repetida dos mesmos tipos “desvios” cometidos pelas crianças no início da alfabetização. Com o objetivo de verificar o porquê dessas ocorrências e em que medida elas se repetem, foram analisadas 146 redações do SARESP de alunos das 8ªs e 3ªs séries do ensino fundamental e médio de uma escola do interior deSão Paulo. A análise de tais “desvios”, quer sejam de segmentação da palavra escrita ou ortográficos, mostra que muitos alunos ainda ignoram a marca convencional da escrita alfabética padrão e saem do curso secundário escrevendo a sua maneira. Isso nos levou a postular o aparecimento de uma interescrita. Apesar de resistente e de persistir como proposta de produção de texto de muitos alunos, essa escrita intermediária pode ser apenas uma fase no longo e árduo processo de autocorreção e aquisição do modelo convencional. A ausência de ensino e de correção sistemática de traços que são próprios da modalidade escrita estavam presentes no ideário construtivista dos anos 1980 e 1990. Nessas ausências talvez estejam as causas desse fracasso escolar, que traz no seu bojo questões de identidade e letramento a serem discutidas.

  3. Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model

    Czech Academy of Sciences Publication Activity Database

    Šedová, Lucie; Pravenec, Michal; Křenová, D.; Kazdová, L.; Zídek, Václav; Krupková, M.; Liška, F.; Křen, Vladimír; Šeda, Ondřej

    2016-01-01

    Roč. 11, č. 3 (2016), č. článku e0152708. E-ISSN 1932-6203 R&D Projects: GA MŠk(CZ) LL1204; GA MŠk(CZ) ED1.1.00/02.0109; GA ČR(CZ) GAP301/12/0696 Institutional support: RVO:67985823 ; RVO:68378050 Keywords : quantitative trait loci * blood-pressure * genetic-determinants * glucose-tolerance * hypertensive-rat * strains * reveals * identification * mechanisms * phenotypes Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.806, year: 2016

  4. Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock.

    Science.gov (United States)

    Yamada, Noriaki; Martin, Lukas B; Zechendorf, Elisabeth; Purvis, Gareth S D; Chiazza, Fausto; Varrone, Barbara; Collino, Massimo; Shepherd, Joanna; Heinbockel, Lena; Gutsmann, Thomas; Correa, Wilmar; Brandenburg, Klaus; Marx, Gernot; Schuerholz, Tobias; Brohi, Karim; Thiemermann, Christoph

    2017-03-10

    To evaluate (1) levels of the host-defense/antimicrobial peptide LL-37 in patients with trauma and hemorrhagic shock (HS) and (2) the effects of a synthetic host-defense peptide; Pep19-4LF on multiple organ failure (MOF) associated with HS. HS is a common cause of death in severely injured patients. There is no specific therapy that reduces HS-associated MOF. (1) LL-37 was measured in 47 trauma/HS patients admitted to an urban major trauma center. (2) Male Wistar rats were submitted to HS (90 min, target mean arterial pressure: 27-32 mm Hg) or sham operation. Rats were treated with Pep19-4LF [66 (n = 8) or 333 μg/kg · h (n = 8)] or vehicle (n = 12) for 4 hours following resuscitation. Plasma LL-37 was 12-fold higher in patients with trauma/HS compared to healthy volunteers. HS rats treated with Pep19-4LF (high dose) had a higher mean arterial pressure at the end of the 4-hour resuscitation period (79 ± 4 vs 54 ± 5 mm Hg) and less renal dysfunction, liver injury, and lung inflammation than HS rats treated with vehicle. Pep19-4LF enhanced (kidney/liver) the phosphorylation of (1) protein kinase B and (2) endothelial nitric oxide synthase. Pep19-4LF attenuated the HS-induced (1) translocation of p65 from cytosol to nucleus, (2) phosphorylation of IκB kinase on Ser, and (3) phosphorylation of IκBα on Ser resulting in inhibition of nuclear factor kappa B and formation of proinflammatory cytokines. Pep19-4LF prevented the release of tumor necrosis factor alpha caused by heparan sulfate in human mononuclear cells by binding to this damage-associated molecular pattern. Trauma-associated HS results in release of LL-37. The synthetic host-defense/antimicrobial peptide Pep19-4LF attenuates the organ injury/dysfunction associated with HS.

  5. Plzf as a Candidate Gene Predisposing the Spontaneously Hypertensive Rat to Hypertension, Left Ventricular Hypertrophy, and Interstitial Fibrosis

    Czech Academy of Sciences Publication Activity Database

    Liška, F.; Mancini, M.; Krupková, M.; Chylíková, B.; Křenová, D.; Šeda, O.; Šilhavý, Jan; Mlejnek, Petr; Landa, Vladimír; Zídek, Václav; d´Amati, G.; Pravenec, Michal; Křen, Vladimír

    2014-01-01

    Roč. 27, č. 1 (2014), s. 99-106 ISSN 0895-7061 R&D Projects: GA ČR(CZ) GAP301/10/0756; GA ČR(CZ) GAP301/12/0696; GA MŠk(CZ) LL1204; GA MŠk(CZ) 7E10067 Grant - others:Univerzita Karlova(CZ) PRVOUK-P25/LF1/2 Institutional support: RVO:67985823 Keywords : hypertension * left ventricular hypertrophy * myocardial interstitial fibrosis * spontaneously hypertensive rat * Plzf (promyelocytic leukemia zinc finger) gene Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.852, year: 2014

  6. Threshold resummation at N{sup 3}LL accuracy and soft-virtual cross sections at N{sup 3}LO

    Energy Technology Data Exchange (ETDEWEB)

    Catani, Stefano [INFN, Sezione di Firenze and Dipartimento di Fisica e Astronomia, Università di Firenze, I-50019 Sesto Fiorentino, Florence (Italy); Cieri, Leandro [Dipartimento di Fisica, Università di Roma “La Sapienza” and INFN, Sezione di Roma, I-00185 Rome (Italy); Florian, Daniel de [Departamento de Física, FCEYN, Universidad de Buenos Aires, (1428) Pabellón 1 Ciudad Universitaria, Capital Federal (Argentina); Ferrera, Giancarlo [Dipartimento di Fisica, Università di Milano and INFN, Sezione di Milano, I-20133 Milan (Italy); Grazzini, Massimiliano [Physik-Institut, Universität Zürich, CH-8057 Zürich (Switzerland)

    2014-11-15

    We consider QCD radiative corrections to the production of colorless high-mass systems in hadron collisions. We show that the recent computation of the soft-virtual corrections to Higgs boson production at N{sup 3}LO [1] together with the universality structure of soft-gluon emission can be exploited to extract the general expression of the hard-virtual coefficient that contributes to threshold resummation at N{sup 3}LL accuracy. The hard-virtual coefficient is directly related to the process-dependent virtual amplitude through a universal (process-independent) factorization formula that we explicitly evaluate up to three-loop order. As an application, we present the explicit expression of the soft-virtual N{sup 3}LO corrections for the production of an arbitrary colorless system. In the case of the Drell–Yan process, we confirm the recent result of Ref. [2].

  7. Mössbauer parameters of ordinary chondrites influenced by the fit accuracy of the troilite component: an example of Chelyabinsk LL5 meteorite

    Energy Technology Data Exchange (ETDEWEB)

    Maksimova, A. A. [Ural Federal University, Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology (Russian Federation); Klencsár, Z. [Hungarian Academy of Sciences, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences (Hungary); Oshtrakh, M. I., E-mail: oshtrakh@gmail.com; Petrova, E. V.; Grokhovsky, V. I. [Ural Federal University, Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology (Russian Federation); Kuzmann, E.; Homonnay, Z. [Eötvös Loránd University, Institute of Chemistry (Hungary); Semionkin, V. A. [Ural Federal University, Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology (Russian Federation)

    2016-12-15

    The influence of the fit accuracy of the troilite component in the Mössbauer spectra of ordinary chondrites on the parameters obtained for other spectral components was evaluated using the Mössbauer spectrum of Chelyabinsk LL5 meteorite fragment with light lithology as a typical example. It was shown that with respect to the application of a usual sextet component where quadrupole interaction is taken into account in the first-order perturbation limit, substantial improvement of the spectrum fit can be achieved either by using the full Hamiltonian description of the troilite component or by its formal approximation with the superposition of three symmetric doublet components. Parameter values obtained for the main spectral components related to olivine and pyroxene were not sensitive to the fit of troilite component while parameters of the minor spectral components depended on the way of troilite component fitting.

  8. Genetical structure of populations of modelling species of terrestrial mollusks in conditions of the urbanized landscape on example Сhondrula tridens Müll (Gastropoda, Pulmonata

    Directory of Open Access Journals (Sweden)

    Eduard A Snegin

    2011-06-01

    Full Text Available On the basis of the analysis of the morphological and genetical variability revealed by a method of gel-electrophoresis of proteins in PAAG, the state of gene pools of populations of modeling species Сhondrula tridens Müll (threedens snail in conditions of the urbanized forest-steppe landscape of the south of Mid-Russia Upland is investigated. In the majority of the investigated bunches authentic decrease of a level of heterozygosity and the decrease of an allelic diversification caused, both is fixed by natural historical factors, and factors of an anthropogenic parentage. The genetic-automatic processes in populations are considered and vectors of natural selection are defined. Calculation of effective number of researched bunches is spent.

  9. Complete characterization of the spasing (L-L) curve of a three-level quantum coherence enhanced spaser for design optimization

    Science.gov (United States)

    Kumarapperuma, Lakshitha; Premaratne, Malin; Jha, Pankaj K.; Stockman, Mark I.; Agrawal, Govind P.

    2018-05-01

    We demonstrate that it is possible to derive an approximate analytical expression to characterize the spasing (L-L) curve of a coherently enhanced spaser with 3-level gain-medium chromophores. The utility of this solution stems from the fact that it enables optimization of the large parameter space associated with spaser designing, a functionality not offered by the methods currently available in the literature. This is vital for the advancement of spaser technology towards the level of device realization. Owing to the compact nature of the analytical expressions, our solution also facilitates the grouping and identification of key processes responsible for the spasing action, whilst providing significant physical insights. Furthermore, we show that our expression generates results within 0.1% error compared to numerically obtained results for pumping rates higher than the spasing threshold, thereby drastically reducing the computational cost associated with spaser designing.

  10. Ameliorated effects of Lactobacillus delbrueckii subsp. lactis DSM 20076 and Pediococcus acidilactici NNRL B-5627 on Fumonisin B1-induced Hepatotoxicity and Nephrotoxicity in rats

    Directory of Open Access Journals (Sweden)

    Amira A. Abdellatef

    2016-04-01

    Full Text Available Oxidative stress has been implicated in a number of human regeneration and disease processes including atherosclerosis, pulmonary fibrosis, cancer, and different neurodegenerative diseases. The aim of this study was to evaluate the protective effects of Lactobacillus delbrueckii subsp. lactis DSM 20076 (LL-DSM and Pediococcus acidilactici NNRL B-5627 (PA-NNRL against the hepatic- and nephro-toxicity of fumonisin B1 (FB1 in FB1-treated rats for an experimental period of 4-weeks. Eighty mature male Sprague-Dawley rats were divided to 12 groups: 1 untreated group; 3 groups fed by a FB1-contaminated diet (50, 100 and 200 mg FB1/kg diet, respectively; 1 group fed orally by LL-DSM (1 ml/d; 1 group fed orally by PA-NNRL (1 ml/d; 3 groups co-administered by FB1-contaminated diet and LL-DSM (1 ml/d, and 3 groups co-administered by FB1-contaminated diet and PA-NNRL (1 ml/d. Malonaldehyde (MDA nitric oxide, glutathione content, SOD activity, total antioxidant capacity (TAC, total oxidant status (TOS and oxidative stress index (OSI were determined. DPA assay was used to assess apoptosis in liver and kidney tissues. The animals fed with FB1-contaminated diet showed a significant increase in oxidative stress markers and DNA fragmentation accompanied with significant decrease in GSH content, SOD activity, and TAC in liver and kidney tissues, especially at high-dosage of FB1 (T200. Probiotics antioxidant strains (LL-DSM and PA-NNRL relatively succeeded to restore almost all parameters investigated as well as to reduce DNA fragmentation in liver and kidney tissues. As a conclusion, probiotics may induce its protective role via increasing the antioxidant capacity, inhibition of lipid peroxidation, scavenging of free radicals and decreasing DNA lesions in liver and kidney of experimental animals tested.

  11. Cycles of time in the Iberian culture: the astronomical orientation of the temple of El Tossal de Sant Miquel de Llíria

    Directory of Open Access Journals (Sweden)

    Esteban, César

    2006-06-01

    Full Text Available We present an archaeoastronomical study of the temple of the Iberian settlement of El Tossal de Sant Miquel de Llíria (València. We find that the major axis of the building is oriented very close to the east-west cardinal axis. The entrance of the temple is pointing towards an outstanding mountain on the eastern horizon, where the sunrise around the equinoxes takes place. On the other hand, the absence of other constructions just in front of the cultic building seems to support the inference that the astronomical relation was intentional, because it would permit the observation of the sunrise from the temple. The existence of other nearby Iberian sanctuaries showing similar relations with the equinoxes (or a date very close to them strongly supports the importance of these solar dates in the Iberian ritual.

    Presentamos un estudio arqueoastronómico del templo del poblado ibérico del Tossal de Sant Miquel de Llíria (Valencia. Encontramos que el eje mayor del edificio se encuentra orientado casi paralelo al eje cardinal este-oeste, con su entrada apuntando hacia una montaña singular del horizonte oriental donde se produce el orto solar alrededor de los equinoccios. Por otra parte, la ausencia de construcciones justo enfrente de la entrada del templo parece apoyar la intencionalidad de dicha relación astronómica, pues permitiría preservar la observación del fenómeno desde el edificio. La existencia de otros yacimientos ibéricos cercanos donde se han encontrado relaciones similares con los equinoccios (o una fecha muy cercana a éstos apunta, cada vez más claramente, hacia la idea de un especial protagonismo del paso del sol por los equinoccios en el calendario ritual ibérico.

  12. Design of a virtual tour for the enhancement of Llíria’s architectural and urban heritage and its surroundings

    Directory of Open Access Journals (Sweden)

    José Miguel Maícas

    2017-07-01

    Full Text Available The Information Technology and Communications (ICT have revolutionized the way to present and promote the heritage sites. These ICT also offer scholars, students and visitors unprecedented access to architectural, historical, geographical, archaeological, iconographical and anthropological data, among other. It is noted also that virtual heritage environments are inherently fascinating and possess essential properties to have a positive effect on supporting heritage conservation and education. This paper is concerned with the potential of these ICT developments for improving the enhancement of the heritage sites of the town of Llíria and its surroundings (Valencia, Spain by mean of a virtual tour (“Edeta 360º” based on 360º panorama photos. The “Edeta 360º” virtual tour is an immersive application that places the viewers inside the image, enabling them to significantly enhance position awareness and providing the highest level of functionality for viewing, capturing and analysing virtual data. It can appropriately and effectively be utilised to facilitate intellectual and physical access to public by bringing knowledge, awareness and appreciation about the heritage of Llíria while, at the same time, authenticity is preserved. The undertaking method to create this interactive virtual tour is based on an easy procedure with off-the-shelf equipment and using both freely available software to address the process of photo stitching that combines multiple photographic images with overlapping fields of view to produce a segmented panorama or high-resolution image. Each panorama contains hotspots that enable the users to further explore the surroundings. The virtual tour provides the user the ability to navigate a scene through the rotation and zoom functions. This application results very appealing and has been adopted as a mean for information, dissemination, education and tourism purposes.

  13. IL-33 mast cell axis is central in LL-37 induced bladder inflammation and pain in a murine interstitial cystitis model.

    Science.gov (United States)

    Martin Jensen, M; Jia, Wanjian; Schults, Austin J; Ye, Xiangyang; Prestwich, Glenn D; Oottamasathien, Siam

    2018-05-18

    Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is a debilitating chronic condition that afflicts over 3 million women above the age of 18 in the U.S., and most patients fail to respond to current treatment options. Mast cells have previously been implicated as both a diagnostic and prognostic marker in IC/PBS. Patients with IC/PBS have been shown to have elevated levels of IL-33, a cytokine released in response to tissue insult, in their urine. We hypothesize that mast cell-mediated inflammation induced from IL-33 may play an important role in initiating pain and inflammation in IC/PBS. A human cathelicidin, LL-37, which is found at elevated levels in IC/PBS patients, was used to induce an IC/PBS-like state of inflammation and bladder pain in mast cell deficient C-kit (-/-) and wild type C57Bl/6 (WT) mice. Inflammation was quantified using myeloperoxidase (MPO) expression in bladder tissues measured via ELISA. Response rate to suprapubic stimulation from von Frey filaments was used to assess the relative pain and discomfort. Both types of mice increased IL-33 expression in response to LL-37 exposure. However, mast cell deficient mice demonstrated significantly lower levels of inflammation (p < 0.001) and reduced pain response (p < 0.001) compared to WT mice. These findings implicate an IL-33-mast cell dependent axis with a potential etiology of pain and inflammation in IC/PBS. Future therapeutics aimed at targeting the IL-33 - mast cell axis could potentially serve as useful targets for treating IC/PBS. Copyright © 2018. Published by Elsevier Ltd.

  14. Environmental risk assessment of pesticides in the River Madre de Dios, Costa Rica using PERPEST, SSD, and msPAF models

    NARCIS (Netherlands)

    Ramo, R.; Brink, van den P.J.; Ruepert, C.; Castillo, L.; Gunnarsson, J.S.

    2016-01-01

    This study assesses the ecological risks (ERA) of pesticides to aquatic organisms in the River Madre de Dios (RMD), which receives surface runoff water from banana, pineapple, and rice plantations on the Caribbean coast of Costa Rica. Water samples collected over 2 years at five sites in the RMD

  15. DEUS É AMOR: ACULTURAÇÃO RELIGIOSA E ETNOCÍDIO ENTRE OS GUARANI KAIOWÁ NA ALDEIA BORORÓ DE DOURADOS, MS

    Directory of Open Access Journals (Sweden)

    Fabíola Renata Caldas

    2012-10-01

    Full Text Available Tivemos por objetivo no presente trabalho analisar a evangelização realizada pelas missões evangélicas e católicas em povos indígenas, destacando os diferentes métodos utilizados pelas missões, que seriam a transculturação e a inculturação. Outrossim, discutimos o genocídio cultural, também denominado etnocídio, conduta não tipificada como crime, tampouco reconhecida perante o Tribunal Penal Internacional e o Estatuto de Roma, mas que decorre do extermínio do “outro”, por meio da destruição da sua cultura, religião, língua, etc. Ao final, analisamos a atuação dos evangélicos em aldeias de Dourados e seu entorno, dando enfoque ao caso concreto da Igreja Pentecostal Deus é Amor, entre o povo Guarani Kaiowá, na Aldeia Bororó na cidade de Dourados, que sofreu e ainda sofre uma forma de genocídio cultural por meio da transculturação realizada por essa missão evangélica. Palavras-chave: Missões. Povos indígenas. Etnocídio.

  16. Assédio moral nas instituições de ensino superior: um estudo sobre as condições organizacionais que favorecem sua ocorrência

    Directory of Open Access Journals (Sweden)

    Míriam Rodrigues

    Full Text Available Este artigo investiga as condições organizacionais que favorecem a ocorrência de assédio moral no ambiente de trabalho, a partir da perspectiva de professores atuantes em cursos de administração de empresas de instituições de ensino superior (IES privadas na cidade de São Paulo. Foi realizada uma pesquisa qualitativa baseada em dados provenientes de entrevistas e análise documental, submetidos à análise de conteúdo. Os resultados evidenciaram que o assédio moral é motivado tanto por questões de ordem pessoal, quanto por questões organizacionais e que tem como elementos deflagradores o posicionamento das IES privadas no cenário competitivo em que estão inseridas e a fragilidade ou inexistência de normas e processos referentes à prevenção e ao tratamento de casos de assédio moral. Os resultados evidenciaram que o assédio moral é motivado tanto por questões de ordem pessoal, quanto organizacionais, tendo como elementos deflagradores o posicionamento das IES privadas no cenário competitivo em que estão inseridas e a fragilidade ou inexistência de normas e processos referentes à prevenção e ao tratamento do problema.

  17. Assédio moral no judiciário: Prevalência e repercussões na saúde dos trabalhadores

    Directory of Open Access Journals (Sweden)

    Adriana Machado Pooli

    2018-04-01

    Full Text Available O objetivo deste estudo foi investigar a prevalência do assédio moral e suas repercussões na saúde de trabalhadores em uma instituição judiciária. Adotou-se método quantitativo, transversal e de caráter descritivo. Analisou-se a organização do trabalho, situações de assédio moral e possíveis associações entre o assédio moral e danos à saúde. Como instrumentos, foram aplicados um questionário biossociodemográfico e laboral e o Questionário de Atos Negativos (QAN. Os resultados evidenciaram que 37% dos respondentes foram submetidos a práticas de assédio moral na medida objetiva e 6,2% pela medida subjetiva, que 75% dos participantes indicaram o superior hierárquico como agressor e que os comportamentos negativos relacionados ao contexto e à gestão do trabalho preponderaram sobre os atos hostis direcionados à pessoa. Apareceram como repercussões na saúde depressão, ansiedade, nervosismo, irritabilidade, angústia, crises de choro, insônia, problemas digestivos e tensão muscular. Concluiu-se que ser alvo de atos hostis tem relação com danos à saúde.

  18. Floração e frutificação em diferentes tipos de cladódios de pitaia-vermelha em Lavras -MG

    Directory of Open Access Journals (Sweden)

    Ana Claudia Costa

    2014-03-01

    Full Text Available Recentemente, algumas espécies de cactáceas têm-se destacado quanto ao potencial como frutíferas, sendo suas frutas utilizadas como alimento para o homem. dentre essas, a pitaia tem despertado grande interesse. O presente trabalho teve como objetivo estudar a floração e a frutificação em diferentes tipos de cladódios (tamanho e presença ou ausência de frutificação em safras anteriores de pitaia-vermelha em Lavras-MG. As observações foram realizadas em plantas de pitaia-vermelha [Hylocereus undatus (haw. Britton & Rose], com quatro anos de idade, tutoradas em mourões de eucalipto com 1,80 m de altura, no espaçamento de 3 x 3 m. Do surgimento do botäo floral até a abertura da flor, decorreram cerca de 21 dias, e da antese até a colheita do fruto, cerca de 35 dias. Cladódios que já haviam produzido frutos em anos anteriores e com tamanho entre 40 e 60 cm de comprimento apresentaram maior porcentagem de cladódios com frutos e maior número de frutos por cladódio.

  19. Tendência da mortalidade por suicídio na população brasileira e idosa, 1980-2006

    Directory of Open Access Journals (Sweden)

    Maria Cecília de Souza Minayo

    2012-04-01

    Full Text Available OBJETIVO: Descrever a mortalidade por suicídio no Brasil, com destaque para a população idosa. MÉTODOS: Análise temporal e estudo de tendência por regressão polinomial de suicídios na população acima de dez anos no Brasil e no Estado do Rio de Janeiro de 1980 a 2006. Os dados foram extraídos do Sistema de Informações sobre Mortalidade e as taxas, calculadas segundo sexo e faixa etária, considerando-se a população residente fornecida pelo Datasus por 100 mil habitantes. Para os anos de 1980 a 1995, utilizou-se a nona revisão da Classificação Internacional de Doenças e Problemas Relacionados à Saúde, e para 1996 a 2006, a décima revisão. RESULTADOS: Crescimento significativo foi observado nas taxas de suicídio na população brasileira e no Rio de Janeiro (5,7 e 3,1 para cada 100 mil habitantes, respectivamente em 2006. Esse incremento ocorreu pelo aumento dos suicídios na população masculina em todas as idades. A curva crescente aconteceu principalmente entre homens maiores de 60 anos. O incremento não foi estatisticamente significativo entre homens e houve decréscimo entre mulheres no Rio de Janeiro. Os principais meios de suicídio utilizados pelos homens foram enforcamento, sufocação, estrangulamento e armas de fogo. Para as mulheres, o enforcamento também ocupou a primeira posição, seguido pela ingestão de substâncias, atiramento ao fogo e precipitação de altura. A elevada taxa de indefinição dos meios ressaltou problemas na qualidade dos dados. CONCLUSÕES: Suicídios são eventos significantes na população masculina, sobretudo entre homens idosos, ao longo do tempo. No Rio de Janeiro, as taxas entre homens idosos também são maiores, mas não estatisticamente significantes. Segundo a Organização Mundial da Saúde e o Ministério da Saúde, o suicídio é passível de prevenção e existem cuidados preconizados para cada grupo etário.

  20. Assédio moral no trabalho e suas representações na mídia jornalística

    Directory of Open Access Journals (Sweden)

    Andréia De Conto Garbin

    2012-06-01

    Full Text Available OBJETIVO: Analisar os discursos sobre assédio moral veiculados na mídia jornalística impressa. PROCEDIMENTOS METODOLÓGICOS: Estudo documental referente ao assédio moral no trabalho, no qual foram analisadas as matérias jornalísticas veiculadas em três jornais de grande circulação do estado de São Paulo, no período de 1990 a 2008. A partir da metodologia de análise do discurso foram reconhecidas as práticas discursivas que configuram o fenômeno do assédio moral na sociedade atual, as explicações para sua ocorrência e a repercussão para a saúde dos trabalhadores. ANÁLISE DOS RESULTADOS: O surgimento do tema nos veículos de comunicação deu-se por meio da divulgação de livros, de produções acadêmicas e de legislações. Ocorreu em editorias que tratam de assuntos gerais e, posteriormente, migrou para as editorias de emprego e/ou de caráter econômico-financeiro. Os discursos de natureza indenizatória, de precaução empresarial e as estratégias de enfrentamento são amplamente difundidos. A promoção da saúde se esvai pela lógica patrimonial. Há um espaço permissivo nas organizações para prática do assédio moral, potencializando os conflitos para atingir as metas e resultados. Indiferença, constrangimentos, desqualificações e ridicularizações foram comuns nas matérias. CONCLUSÕES: As explicações sobre o assédio tendem a uma interpretação psicológica do fenômeno, acentuando o caráter individualista e minimizando uma abordagem coletiva. Os discursos banalizam o assédio ao criarem caricaturas para os atores envolvidos. O conteúdo psicológico e a estigmatização produzem sentido na sociedade, contribuindo para naturalizar o assédio moral no trabalho e banalizar a violência no trabalho.

  1. A Rádio Educativa Unoesc FM como recurso didático na Educação a Distância

    Directory of Open Access Journals (Sweden)

    Roseli Rocha Moterle

    2010-07-01

    Full Text Available A Educação a Distância é uma modalidade de ensino que utiliza diversos meios e tecnologias de informação e comunicação no processo de mediação, de modo que favoreçam a construção do conhecimento e da autonomia de aprendizagem do aluno. Neste artigo apresentam-se os resultados de um projeto de pesquisa, cujo objetivo foi investigar as contribuições da Rádio Educativa no processo de ensino-aprendizagem das disciplinas de Metodologia Científica e de Ética e Sociedade, oferecidas pela Universidade do Oeste de Santa Catarina (Unoesc, na modalidade a distância, por meio de uma radionovela, destacando conflitos éticos em debate na sociedade atual: aborto, pena de morte, plágio e formação ética. A pesquisa foi organizada em três momentos: inicialmente, foram elaborados roteiros dos episódios da radionovela; num segundo momento, foram gravados os programas e veiculados na Rádio Educativa 106,7 FM, na internet ou por download; num terceiro momento, foi disponibilizado aos alunos, por meio do Portal de Ensino, um questionário de pesquisa para avaliar as contribuições desse recurso no processo de ensino-aprendizagem, com a participação de 63% dos alunos matriculados nas disciplinas. Os resultados apontam a Rádio Educativa como um importante recurso didático na Educação a Distância, pois facilita a compreensão dos conteúdos, problematiza situações e casos que se aproximam da realidade do aluno e aprofunda a reflexão de questões difíceis de se reproduzir no material impresso. Recomenda-se a elaboração de novos projetos por meio da Rádio Educativa, aprimorando técnica e metodologicamente o uso da rádio como um recurso didático, a fim de contribuir no processo de ensino-aprendizagem, especialmente na modalidade a distância. Palavras-chave: Rádio Educativa. Radionovela. Educação e Comunicação. Educação a Distância.

  2. Tentativas de suicídio em um hospital geral no Rio de Janeiro, Brasil Suicide attempts recorded at a general hospital in Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Guilherme L. Werneck

    2006-10-01

    Full Text Available A história pregressa de tentativa de suicídio é um importante preditor do suicídio e de novas tentativas. Este artigo apresenta o perfil dos casos de tentativas de suicídio detectados por meio de um sistema de monitoramento para esses agravos em um hospital geral no Rio de Janeiro, Brasil. Entre abril de 2001 e março de 2002 foram registrados 160 tentativas de suicídio, sendo 68% entre mulheres e 26% entre adolescentes. A ingestão de pesticidas e o abuso de medicamentos foram os principais métodos utilizados. Mulheres utilizaram os dois métodos na mesma proporção, enquanto 2/3 dos homens empregaram pesticidas. Em relação à prevalência dos fatores de risco para tentativas de suicídio, identificou-se que 21% dos pacientes haviam procurado serviços de saúde nos trinta dias anteriores ao evento, 28% referiram tentativas anteriores, 23% fizeram referência a casos de tentativas ou suicídio na família. Ainda que os dados populacionais disponíveis sejam escassos, as tentativas de suicídio parecem ser um evento importante de morbidade, particularmente entre adolescentes e adultos jovens. Sistemas de vigilância para esse agravo podem ser úteis para um melhor conhecimento do problema.Previous suicide attempts are an important predictor of both repeated attempts and suicide. This paper presents the profile of patients who had attempted suicide and were admitted to a general hospital in Rio de Janeiro, Brazil. From April 2001 to March 2002, 160 suicide attempts were recorded (68% women; 26% adolescents. Ingestion of pesticides and prescription drugs were the two most common methods used. The two methods had been used by similar numbers of women, while two-thirds of men had used pesticides. As for prevalence of factors associated with attempted suicide, 21% of patients had been in contact with health services within 30 days prior to the event, 28% mentioned previous suicide attempts, and 23% reported other cases of suicide or

  3. Differential effects of genetic - and diet - induced obesity on fertility, spermatogenesis and sperm epigenome in adult male rats

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    Sharvari Deshpande

    2017-10-01

    Full Text Available Obesity is a global health issue affecting millions of people of different age groups. The incidence of male obesity induced infertility is rising in couples undergoing ARTs suggesting that obesity is an established risk factor for male infertility. Recent studies demonstrate that paternal diet induced obesity could induce epigenetic disturbances in offspring. Obesity is a multifactorial disorder with predominantly genetic or environmental causes. No studies have compared the effect of genetic and diet induced obesity on male reproduction. The present study aims to delineate effects of obesity on male fertility, spermatogenesis and sperm epigenome using two rat models: genetically induced obese (GIO – WNIN/OB and diet induced obese (DIO – High fat diet. Body weights were similar in both groups, but, differential effects on hormonal profiles were observed. Fertility assessment showed decreased litter size mainly due to increased pre- and post-implantation loss in DIO group. However, GIO group were infertile due to decrease in libido. We observed a decrease in sperm counts in GIO group but not in DIO group despite the body weights being similar in both the groups. Flow cytometry and cell type specific marker expression studies in testis revealed that both DIO and GIO affect mitosis and differentiation process by increasing spermatogonial proliferation. In DIO group, no effect was observed on meiosis whereas in GIO group, we observed an effect on meiosis. Spermiogenesis process was affected in both the groups. In order to study the effect of genetic and diet induced obesity on different aspects of spermatogenesis, we performed qRT-PCR to study expression of genes involved in spermatocyte progression, spermiogenesis process, reproductive hormone receptors and leptin signaling in testis. Since epigenetic mechanisms are susceptible to environmental and genetic changes, we analyzed the methylation status of Igf2-H19 DMR in spermatozoa of both the

  4. Produção e composição mineral da beterraba sob doses de sódio e potássio, em solução nutritiva

    OpenAIRE

    Carvalho, Karina Fernandes

    2014-01-01

    Altas concentrações de sódio podem diminuir o rendimento de diversas culturas. Entretanto o sódio é um elemento benéfico à beterraba, podendo substituir as funções do potássio. Estudos mostraram que o sódio é responsável pelo aumento da produção de beterraba açucareira e hortícola. O presente trabalho objetivou verificar a resposta da nutrição com sódio em substituição e em adição à nutrição potássica sobre o crescimento, produção, composição mineral e a relação do sódio com os macronutriente...

  5. RatMap--rat genome tools and data.

    Science.gov (United States)

    Petersen, Greta; Johnson, Per; Andersson, Lars; Klinga-Levan, Karin; Gómez-Fabre, Pedro M; Ståhl, Fredrik

    2005-01-01

    The rat genome database RatMap (http://ratmap.org or http://ratmap.gen.gu.se) has been one of the main resources for rat genome information since 1994. The database is maintained by CMB-Genetics at Goteborg University in Sweden and provides information on rat genes, polymorphic rat DNA-markers and rat quantitative trait loci (QTLs), all curated at RatMap. The database is under the supervision of the Rat Gene and Nomenclature Committee (RGNC); thus much attention is paid to rat gene nomenclature. RatMap presents information on rat idiograms, karyotypes and provides a unified presentation of the rat genome sequence and integrated rat linkage maps. A set of tools is also available to facilitate the identification and characterization of rat QTLs, as well as the estimation of exon/intron number and sizes in individual rat genes. Furthermore, comparative gene maps of rat in regard to mouse and human are provided.

  6. DIO COMUNITÁRIA NA TRÍPLICE FRONTEIRA: participação étnica e de gênero na Rádio Norte FM

    Directory of Open Access Journals (Sweden)

    Maria Inês Amarante

    2016-08-01

    Full Text Available O artigo apresenta um recorte da pesquisa “Radiofonia Comunitária na Tríplice Fronteira: gênero, etnia e inclusão social midiática”, cuja proposta é um estudo aprofundado sobre a participação desses grupos nas rádios comunitárias das regiões das fronteiras entre o Paraná, o Paraguai e a Argentina e o modo como estas emissoras têm favorecido a cidadania comunicativa. Em destaque, o caso da Rádio Norte FM da cidade de Cascavel, na região oeste do Paraná. Atualmente, a emissora emite 24 horas e também pode ser ouvida online. Ela abre espaço para as manifestações culturais locais e procura dar vez e voz às reivindicações de diversos movimentos sociais, cedendo-lhes espaço ao longo da programação. Este trabalho foi realizado a partir de pesquisas bibliográfica e documental, visita de campo, entrevistas e questionários dirigidos a diretores e comunicadores.   PALAVRAS-CHAVE: Radiodifusão Comunitária; Gênero; Etnia; Participação. ABSTRACT This article presents part of the research “Community Radiophonic in the Triple Border: gender, ethnicity and social inclusion media”, whose proposal is a thorough study of this groups participation in community radio stations, in the regions of the borders, between the State of Parana, Paraguay and Argentina and how these vehicles have favored the communicative citizenship. Highlighting the case of Radio North FM, in the city of Cascavel, western region of Parana. Currently, the radio remains 24 hours on the air and is present online. It makes room for cultural events in all its expressions and it seeks to give time and voice to the demands of social movements giving them spaces along with the schedule of the programs. This work is based on bibliographic and documentary research, field visits, interviews and questionnaires addressed to directors and communicators.   KEY WORDS: Community Radios, gender, ethnicity and social participation.     RESUMEN El artículo presenta

  7. Desigualdades na mortalidade por suicídio entre indígenas e não indígenas no estado do Amazonas, Brasil

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    Maximiliano Loiola Ponte de Souza

    2013-12-01

    Full Text Available OBJETIVO: Analisar as taxas e algumas características da mortalidade por suicídio entre indígenas e não indígenas no Amazonas. MÉTODO: Estudo de coorte retrospectiva, em que os dados de óbito foram obtidos no Sistema de Informações sobre Mortalidade e os populacionais no Instituto Brasileiro de Geografia e Estatística. Foram utilizados todos os registros de suicídio do período de 2006-2010 e a interpolação geométrica anual para a estimação das subpopulações. RESULTADOS: Ocorreram 688 suicídios no Amazonas, dos quais 19,0% em indígenas. A taxa ajustada de mortalidade por suicídio (TAMS nos indígenas, de 18,4/100 mil, foi 4,4 vezes superior a dos não indígenas. A TAMS em indígenas aumentou 1,6 vez em 2010 em relação a 2006. Nos municípios de Tabatinga e São Gabriel da Cachoeira, as TAMS foram muito altas, 75,8 e 41,9/100 mil, respectivamente. CONCLUSÕES: Evidenciou-se o comportamento desigual das taxas de mortalidade por suicídio entre indígenas e não indígenas, expondo não só sua importância local, como também sua invisibilidade como problema de saúde pública, principalmente entre jovens 15 e 24 anos.

  8. O custo médio direto do material utilizado em cirurgia de revascularização do miocárdio

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    Bittar Eliana

    2003-01-01

    Full Text Available OBJETIVOS: Verificar o custo médio direto do material usado em cirurgia de revascularização do miocárdio e comparar o custo médio encontrado segundo o número de pontes de safena realizadas. MÉTODOS: Como referencial teórico para apuração dos custos utilizou-se o sistema de custeio de absorção por produto/procedimento. A pesquisa, do tipo descritiva, foi realizada no centro cirúrgico de um hospital especializado em cardiologia, no município de São Paulo. A amostra foi conformada por 104 cirurgias de revascularização do miocárdio. RESULTADOS: O levantamento do consumo possibilitou aferição do custo médio direto de material usado em cirurgia de revascularização do miocárdio que resultou em R$2.718,78. CONCLUSÕES: Houve uma variação de custos do material, em relação ao número de pontes de safena realizadas, havendo uma diferença significativa entre as cirurgias de 1, 2 e 3 pontes, o que não ocorreu entre as cirurgias de 3, 4 e 5 pontes. O custo médio direto das cirurgias foi: 1 ponte (R$2.207,71, 2 pontes (R$2.554,61, 3 pontes (R$2.768.94, 4 pontes (R$2.848,65 e 5 pontes (R$2.884,13. Os itens de material de perfusão (R$1.051,24, fios cirúrgicos (R$829,98 e material de consumo (R$442,40 foram os que apresentaram o maior custo médio.

  9. The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome.

    Science.gov (United States)

    Steiner, Michel A; Sciarretta, Carla; Pasquali, Anne; Jenck, Francois

    2013-01-01

    The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditions. Here we investigated the effects of chronic treatment with the novel selective OXR-1 antagonist ACT-335827 in a rat model of diet-induced obesity (DIO) associated with metabolic syndrome (MetS). Rats were fed either standard chow (SC) or a cafeteria (CAF) diet comprised of intermittent human snacks and a constant free choice between a HF/sweet (HF/S) diet and SC for 13 weeks. Thereafter the SC group was treated with vehicle (for 4 weeks) and the CAF group was divided into a vehicle and an ACT-335827 treatment group. Energy and water intake, food preference, and indicators of MetS (abdominal obesity, glucose homeostasis, plasma lipids, and blood pressure) were monitored. Hippocampus-dependent memory, which can be impaired by DIO, was assessed. CAF diet fed rats treated with ACT-335827 consumed less of the HF/S diet and more of the SC, but did not change their snack or total kcal intake compared to vehicle-treated rats. ACT-335827 increased water intake and the high-density lipoprotein associated cholesterol proportion of total circulating cholesterol. ACT-335827 slightly increased body weight gain (4% vs. controls) and feed efficiency in the absence of hyperphagia. These effects were not associated with significant changes in the elevated fasting glucose and triglyceride (TG) plasma levels, glucose intolerance, elevated blood pressure, and adiposity due to CAF diet consumption. Neither CAF diet consumption alone nor ACT-335827 affected memory. In conclusion, the main metabolic characteristics associated with DIO and MetS in rats remained unaffected by chronic ACT-335827 treatment, suggesting that pharmacological OXR-1 blockade has minimal impact in this model.

  10. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats.

    Science.gov (United States)

    Wang, Lixin; Jacobs, Jonathan P; Lagishetty, Venu; Yuan, Pu-Qing; Wu, Shuping V; Million, Mulugeta; Reeve, Joseph R; Pisegna, Joseph R; Taché, Yvette

    2017-10-01

    High-protein diet (HPD) curtails obesity and/or fat mass, but it is unknown whether it reverses neuroinflammation or alters glucose levels, CCK sensitivity, and gut microbiome in rats fed a Western diet (WD)-induced obesity (DIO). Male rats fed a WD (high fat and sugar) for 12 wk were switched to a HPD for 6 wk. Body composition, food intake, meal pattern, sensitivity to intraperitoneal CCK-8S, blood glucose, brain signaling, and cecal microbiota were assessed. When compared with a normal diet, WD increased body weight (9.3%) and fat mass (73.4%). CCK-8S (1.8 or 5.2 nmol/kg) did not alter food intake and meal pattern in DIO rats. Switching to a HPD for 6 wk reduced fat mass (15.7%) with a nonsignificantly reduced body weight gain, normalized blood glucose, and decreased feeding after CCK-8S. DIO rats on the WD or switched to a HPD showed comparable microbial diversity. However, in HPD versus WD rats, there was enrichment of 114 operational taxonomic units (OTUs) and depletion of 188 OTUs. Of those, Akkermansia muciniphila (enriched on a HPD), an unclassified Clostridiales, a member of the RF39 order, and a Phascolarctobacterium were significantly associated with fat mass. The WD increased cytokine expression in the hypothalamus and dorsal medulla that was unchanged by switching to HPD. These data indicate that HPD reduces body fat and restores glucose homeostasis and CCK sensitivity, while not modifying brain inflammation. In addition, expansion of cecal Akkermansia muciniphila correlated to fat mass loss may represent a potential peripheral mechanism of HPD beneficial effects.

  11. The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Michel Alexander Steiner

    2013-12-01

    Full Text Available The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1 in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF diet conditions. Here we investigated the effects of chronic treatment with the novel selective OXR-1 antagonist ACT-335827 in a rat model of diet-induced obesity (DIO associated with metabolic syndrome (MetS. Rats were fed either standard chow (SC or a cafeteria (CAF diet comprised of intermittent human snacks and a constant free choice between a HF/sweet (HF/S diet and SC for 13 weeks. Thereafter the SC group was treated with vehicle (for 4 weeks and the CAF group was divided into a vehicle and an ACT-335827 treatment group. Energy and water intake, food preference, and indicators of MetS (abdominal obesity, glucose homeostasis, plasma lipids, and blood pressure were monitored. Hippocampus-dependent memory, which can be impaired by DIO, was assessed. CAF diet fed rats treated with ACT-335827 consumed less of the HF/S diet and more of the SC, but did not change their snack or total kcal intake compared to vehicle-treated rats. ACT-335827 increased water intake and the high-density lipoprotein associated cholesterol proportion of total circulating cholesterol. ACT-335827 slightly increased body weight gain (4% versus controls and feed efficiency in the absence of hyperphagia. These effects were not associated with significant changes in the elevated fasting glucose and triglyceride (TG plasma levels, glucose intolerance, elevated blood pressure, and adiposity due to CAF diet consumption. Neither CAF diet consumption alone nor ACT-335827 affected memory. In conclusion, the main metabolic characteristics associated with DIO and MetS in rats remained unaffected by chronic ACT-335827 treatment, suggesting that pharmacological OXR-1 blockade has minimal impact in this

  12. Correction: Forrester, N.L.; Coffey, L.L.; Weaver, S.C. Arboviral Bottlenecks and Challenges to Maintaining Diversity and Fitness during Mosquito Transmission. Viruses 2014, 6, 3991–4004

    Directory of Open Access Journals (Sweden)

    Naomi L. Forrester

    2014-11-01

    Full Text Available In the original manuscript, Forrester, N.L.; Coffey, L.L.; Weaver, S.C. Arboviral Bottlenecks and Challenges to Maintaining Diversity and Fitness during Mosquito Transmission. Viruses 2014, 6, 3991–4004, Figure 1 contains an error, the third bottle was absent from the figure:[...

  13. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass

    DEFF Research Database (Denmark)

    Ratner, Cecilia; Ettrup, Anders; Bueter, Marco

    2012-01-01

    Food intake and body weight are regulated by a complex system of neural and hormonal signals, of which the anorexigenic neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) is central. In this study, rat models of obesity and weight loss intervention were compared with regard to several 5-HT......DIO as compared to pgDR rats corresponds to what is reported in overweight humans and suggests that the dysfunctions of the 5-HT system associated with overeating or propensity to become overweight are polygenically determined. Our results support that the obesity-prone rat model has high translational value...... and suggests that susceptibility to develop obesity is associated with changed 5-HT tone in the brain that may also regulate hedonic aspects of feeding....

  14. Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells

    International Nuclear Information System (INIS)

    Sugisawa, Nobusuke; Matsuoka, Masato; Okuno, Takeo; Igisu, Hideki

    2004-01-01

    When NIH3T3 cells were exposed to CdCl 2 , the three major mitogen-activated protein kinases (MAPKs), extracellular signal-regulated protein kinase (ERK), c-Jun NH 2 -terminal kinase (JNK), and p38, were phosphorylated in a time (1-9 h)- and dose (1-20 μM)-dependent manner. Treatment with a macrocyclic nonaketide compound, LL-Z1640-2 (10-100 ng/ml), suppressed the phosphorylation of MAPKs without affecting the total protein level in cells exposed to 10 μM CdCl 2 for 6 h. CdCl 2 -induced phosphorylation of c-Jun on Ser63 and that on Ser73, and resultant accumulation of total c-Jun protein were also suppressed by LL-Z1640-2 treatment. The in vitro kinase assays also showed significant inhibitory effects of LL-Z1640-2 (at 10 or 25 ng/ml) on JNK and p38 but less markedly. In contrast to JNK and p38, ERK activity was inhibited moderately only at 50 or 100 ng/ml LL-Z1640-2. On the other hand, other JNK inhibitors, SP600125 and L-JNKI1, failed to suppress CdCl 2 -induced activation of the JNK pathway. Among the mouse stress response genes upregulated in response to CdCl 2 exposure, the expressions of hsp68 (encoding for heat shock 70 kDa protein 1; Hsp70-1) and grp78 (encoding for 78 kDa glucose-regulated protein; Grp78) genes were suppressed by treatment with 25 ng/ml LL-Z1640-2. Thus, LL-Z1640-2 could suppress CdCl 2 -induced activation of JNK/p38 pathways and expression of HSP70 family genes in NIH3T3 cells. LL-Z1640-2 seems to be useful to analyze functions of toxic metal-induced JNK/p38 activation

  15. Relação entre homicídio e transtornos mentais Relationship between homicide and mental disorders

    Directory of Open Access Journals (Sweden)

    Alexandre Martins Valença

    2006-10-01

    Full Text Available OBJETIVO: Diversos estudos encontraram uma relação entre transtornos mentais graves e violência. Uma das abordagens de estudo deste tema são as investigações com criminosos homicidas. O objetivo do presente artigo foi investigar a associação entre homicídio e transtornos mentais. MÉTODO: Foi realizada uma revisão da literatura, através das seguintes bases de dados: Medline, Scientific Eletronic Library Online e Lilacs. No sistema Medline também foi pesquisada a seção de artigos relacionados. RESULTADOS: Embora exista uma associação entre transtornos mentais e homicídio, não está claro porque alguns pacientes comportam-se de forma violenta e outros não. Transtornos relacionados ao uso de álcool/drogas e transtornos de personalidade comórbidos e falta de aderência ao tratamento podem aumentar este risco. CONCLUSÕES: É justificável a identificação de pessoas com risco elevado de comportamento violento e oferta de tratamento em serviços de saúde mental para as mesmas. Estes serviços deveriam prevenir a perda de contato e não-colaboração com o tratamento que freqüentemente precedem o homicídio perpetrado por pessoas com transtornos mentais graves. É de fundamental importância que a sociedade e as autoridades governamentais diminuam as barreiras de acesso ao tratamento psiquiátrico e psicossocial.OBJECTIVE: Several studies have found a relationship between severe mental disorders and violence. One of the approaches to study this theme are investigations with homicide offenders. The aim of the present article was to investigate the association between homicide and mental disorders. METHOD: A review of the literature was made through the following databases: Medline, Scientific Eletronic Library Online and Lilacs. In the Medline system, it was also searched the related articles section. RESULTS: Although there is an association between mental disorders and homicide, it is not clear why some patients behave

  16. Ensino médio estatal: menos verba para mais alunos? State secondary education: less funs for more students?

    Directory of Open Access Journals (Sweden)

    Nicholas Davies

    2004-03-01

    Full Text Available O artigo traça um panorama de alguns desafios estruturais e conjunturais para o financiamento da educação estatal, em particular o ensino médio, mostrando que a tendência dos governos tem sido no sentido de gastar menos por aluno, apesar dos discursos oficiais de exaltação da qualidade do ensino. Entre os desafios estruturais, incluem-se o privatismo direto e indireto das políticas oficiais, o descumprimento da exigência de aplicação da verba vinculada à manutenção e ao desenvolvimento do ensino, a perda de recursos vinculados causada pela inflação e pelas medidas de política fiscal, e a pouca confiabilidade dos Tribunais de Contas. Entre os desafios conjunturais, analisamos o Fundo de Manutenção e Desenvolvimento do Ensino Fundamental e de Valorização do Magistério (Fundef, que deixa de fora o ensino médio; a reduzida contribuição federal para o ensino médio; e a fragilidade da proposta do PNE (Plano Nacional de Educação e o uso 'judicioso' do dinheiro público. Por fim, examinamos as perspectivas - pouco animadoras - de financiamento da educação no governo Lula: a ênfase do governo no 'ajuste fiscal', cuja conseqüência foi a diminuição, em termos reais, das verbas para a educação em 2003; e as virtudes e os limites do Fundeb (Fundo da Educação Básica.The article provides an overview of some structural and conjunctural challenges for the funding of State education, particularly secondary education (the 3 years of schooling offered after the 8-year period of compulsory education, showing that the trend of governments has been to spend less per pupil, despite the official discourses exhalting the quality of education. The structural challenges examined include direct and indirect privatism of government policies, the non-compliance of a constitucional requirement that a certain percentage of taxes be invested in education, the loss of funds linked to education caused by inflation and fiscal policies, and

  17. High-protein diet selectively reduces fat mass and improves glucose tolerance in Western-type diet-induced obese rats

    Science.gov (United States)

    Stengel, Andreas; Goebel-Stengel, Miriam; Wang, Lixin; Hu, Eugenia; Karasawa, Hiroshi; Pisegna, Joseph R.

    2013-01-01

    Obesity is an increasing health problem. Because drug treatments are limited, diets remain popular. High-protein diets (HPD) reduce body weight (BW), although the mechanisms are unclear. We investigated physiological mechanisms altered by switching diet induced obesity (DIO) rats from Western-type diet (WTD) to HPD. Male rats were fed standard (SD) or WTD (45% calories from fat). After developing DIO (50% of rats), they were switched to SD (15% calories from protein) or HPD (52% calories from protein) for up to 4 weeks. Food intake (FI), BW, body composition, glucose tolerance, insulin sensitivity, and intestinal hormone plasma levels were monitored. Rats fed WTD showed an increased FI and had a 25% greater BW gain after 9 wk compared with SD (P Diet-induced obese rats switched from WTD to HPD reduced daily FI by 30% on day 1, which lasted to day 9 (−9%) and decreased BW during the 2-wk period compared with SD/SD (P < 0.05). During these 2 wk, WTD/HPD rats lost 72% more fat mass than WTD/SD (P < 0.05), whereas lean mass was unaltered. WTD/HPD rats had lower blood glucose than WTD/SD at 30 min postglucose gavage (P < 0.05). The increase of pancreatic polypeptide and peptide YY during the 2-h dark-phase feeding was higher in WTD/HPD compared with WTD/SD (P < 0.05). These data indicate that HPD reduces BW in WTD rats, which may be related to decreased FI and the selective reduction of fat mass accompanied by improved glucose tolerance, suggesting relevant benefits of HPD in the treatment of obesity. PMID:23883680

  18. Homicídios de adolescentes: refletindo sobre alguns fatores associados Adolescents’ homicide: thinking about some associated factors

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    Sergio Kodato

    2000-01-01

    Full Text Available Este estudo é uma investigação de alguns fatores associados a homicídios praticados contra adolescentes, no município de Ribeirão Preto (SP, onde, no período de 1995 a 1998, foram assassinados 101 adolescentes. A coleta e a análise dos dados foram realizadas através da conjunção das seguintes técnicas: levantamento de dados sociográficos, através da análise dos processos judiciais instaurados no Ministério Público local; observação participante da instituição de internamento no município, destinada para adolescente autor de ato infracional; entrevistas com adolescentes internos pela prática de homicídio (n= 8. Como resultado, pode-se afirmar que as condições de vida que levaram à morte os adolescentes, são fruto de uma sincronização de fatores, onde, além da fragilidade institucional, observa-se como determinantes a disputa pela apropriação de bens materiais, o conflito de interesses financeiros, o tráfico de drogas, e, um modo de relacionamento interpessoal, cuja resolução de situações conflitivas se dá de forma não mediada e violenta.This research is an investigation of some factors associated to homicides committed against adolescents, at the city of Ribeirão Preto (SP, in which, during the period of 1995-1998, 101 children and adolescents were killed. The collect and analysis of data were made throughout the association of the following methods: sociographics data enrollment, analysis of taken lawsuits in the local prosecuting counsel; participant observation of the local internment institution, destined to adolescents authors of infraction acts; interview with intern adolescents for homicide acts (n=8. As a result one may state that the life conditions that ends on death of adolescents are product of a synchronization of factors, where, besides the fragility of institutions, one may observe determinants the dispute for appropriation of goods, conflict of financial interests, drug traffic and, a mode

  19. Efecto del extracto metanólico de Jatropha macrantha Müll. Arg., en la disfunción eréctil inducida en ratas

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    Aldo Tinco

    2011-07-01

    Full Text Available Objetivos: Determinar el efecto del extracto metanólico de Jatropha macrantha Müll. Arg. ‘huanarpo macho’ en la disfunción eréctil inducida en ratas. Diseño: Experimental. Institución: Laboratorio de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú; Laboratorio de Farmacia, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, Perú. Material biológico: Extracto metanólico de Jatropha macrantha Müll Arg. ‘huanarpo macho’; ratas wistar de 300+/-50 g. Intervenciones: La obtención de la muestra se realizó en la Provincia de Vilcas Huamán - Ayacucho. Se evaluó el comportamiento sexual y la concentración de óxido nítrico y el efecto vasorrelajante en el cuerpo cavernoso aislado de pene de ratas, siendo los grupos de estudio: grupo 1 agua 10 mL/kg; grupo 2 sildenafilo 5 mg/kg; grupos 3, 4 y 5 extracto metanólico 100, 200 y 300 mg/kg. Se aisló órganos en los grupos de 50, 100 y 300 ug/mL de extracto, L- arginina 300 uM, acetilcolina 30uM, epinefrina u/mL y sildenafilo (3,2 × 10-5 mg/mL. Principales medidas de resultados: Flavonoides aislados, comportamiento sexual de ratas, niveles plasmáticos de óxido nítrico y relajación del músculo cavernoso. Resultados: Por cromatografía se encontró estructuras tipo flavonas, y mediante espectroscopia UV y reacciones de desplazamiento se identificó 6-hidroxi-4’,5,7-trimetoxi flavona, 4’,7-dihidroxi-5,6-dimetoxiflavona, 7-hidroxi-3’,4’,5’,5,8 pentametoxiflavona, 4’,7-dihidroxi-3’,5,6-trimetoxiflavona, DL50 1357 mg/kg. El comportamiento sexual fue dosis dependiente; la administración de 300 mg/kg de la planta por vía oral incrementó la frecuencia de monta en 75% y elevó los niveles de óxido nítrico en 85%, en tanto que la dosis de 200 mg/kg lo hizo en 71,1% y 32,4%, respectivamente (p<0,05. Conclusiones: En ratas con disfunción eréctil inducida, el extracto metanólico de Jatropha macrantha Müll Arg.

  20. A Rádio Educativa Unoesc FM como recurso didático na Educação a Distância

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    Roseli Rocha Moterle

    2010-07-01

    Full Text Available A Educação a Distância é uma modalidade de ensino que utiliza diversos meios e tecnologias de informação e comunicação no processo de mediação, de modo que favoreçam a construção do conhecimento e da autonomia de aprendizagem do aluno. Neste artigo apresentam-se os resultados de um projeto de pesquisa, cujo objetivo foi investigar as contribuições da Rádio Educativa no processo de ensino-aprendizagem das disciplinas de Metodologia Científica e de Ética e Sociedade, oferecidas pela Universidade do Oeste de Santa Catarina (Unoesc, na modalidade a distância, por meio de uma radionovela, destacando conflitos éticos em debate na sociedade atual: aborto, pena de morte, plágio e formação ética. A pesquisa foi organizada em três momentos: inicialmente, foram elaborados roteiros dos episódios da radionovela; num segundo momento, foram gravados os programas e veiculados na Rádio Educativa 106,7 FM, na internet ou por download; num terceiro momento, foi disponibilizado aos alunos, por meio do Portal de Ensino, um questionário de pesquisa para avaliar as contribuições desse recurso no processo de ensino-aprendizagem, com a participação de 63% dos alunos matriculados nas disciplinas. Os resultados apontam a Rádio Educativa como um importante recurso didático na Educação a Distância, pois facilita a compreensão dos conteúdos, problematiza situações e casos que se aproximam da realidade do aluno e aprofunda a reflexão de questões difíceis de se reproduzir no material impresso. Recomenda-se a elaboração de novos projetos por meio da Rádio Educativa, aprimorando técnica e metodologicamente o uso da rádio como um recurso didático, a fim de contribuir no processo de ensino-aprendizagem, especialmente na modalidade a distância.