WorldWideScience

Sample records for liver test results

  1. Liver Function Tests

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  2. Liver Function Tests

    Science.gov (United States)

    ... digest food, store energy, and remove poisons. Liver function tests are blood tests that check to see ... as hepatitis and cirrhosis. You may have liver function tests as part of a regular checkup. Or ...

  3. Liver Function Tests

    Science.gov (United States)

    ... Legacy Society Make Gifts of Stock Donate Your Car Personal Fundraising Partnership & Support Share Your Story Spread the Word Give While You Shop Contact Us Donate Now Diagnosing Liver Disease – Liver ...

  4. How to interpret liver function tests

    Directory of Open Access Journals (Sweden)

    Christina Levick

    2017-05-01

    Full Text Available Careful interpretation of liver function tests within the clinical context can help elucidate the cause and severity of the underlying pathology. Predominantly raised alkaline phosphatase represents the cholestatic pattern of biliary pathology, whilst predominantly raised alanine aminotransferase and aspartate aminotransferase represent the hepatocellular pattern of hepatocellular pathology. The severity of liver dysfunction or biliary obstruction is reflected in the bilirubin level and the degree of liver synthetic function can also be indicated by the albumin level. Beyond the liver function tests, prothrombin time provides another marker of liver synthetic function and a low platelet count suggests portal hypertension.

  5. Liver Function Tests in Tuberculoid Leprosy

    Directory of Open Access Journals (Sweden)

    R V Korane

    1979-01-01

    Full Text Available A total of 24 patients with untreated tuberculoid leprosy were taken up for study, They were the same group of patients in whom the authors have earlier reported involvement of liver in 85 % cases. Five healthy controls, studied also belonged to the same series. Liver function tests included prothrombin time, serum bilirubin, zinc sulphate turbidity, serum proteins and serum transaminases. No significant alterations in the liver function were observed. This is because the changes in the liver were so minimal and focal that they were not reflected in the various liver function tests.

  6. Correlation with liver scintigram, reticuloendothelial function test, plasma endotoxin level and liver function tests in chronic liver diseases. Multivariate analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ohmoto, Kenji; Yamamoto, Shinichi; Ideguchi, Seiji and others

    1989-02-01

    Liver scintigrams with Tc-99m phytate were reviewed in a total of 64 consecutive patients, comprising 28 with chronic hepatitis and 36 with liver cirrhosis. Reticuloendothelial (RES) function, plasma endotoxin (Et) levels and findings of general liver function tests were used as reference parameters to determine the diagnostic ability of liver scintigraphy. Multivariate analyses revealed that liver scintigrams had a strong correlation with RES function and Et levels in terms of morphology of the liver and hepatic and bone marrow Tc-99m uptake. General liver function tests revealed gamma globulin to be correlated with hepatic uptake and the degree of splenogemaly on liver scintigrams; and ICG levels at 15 min to be correlated with bone marrow and splenic uptake. Accuracy of liver scintigraphy was 73% for chronic hepatitis, which was inferior to general liver function tests (83%). When both modalities were combined, diangostic accuracy increased to 95%. Liver scintigraphy seems to be useful as a complementary approach. (Namekawa, K).

  7. Liver function tests using the stable istope 15N

    International Nuclear Information System (INIS)

    Faust, H.; Jung, K.; Hirschberg, K.; Krumbiegel, P.; Junghans, P.; Reinhardt, R.; Teichmann, B.

    1988-01-01

    Several liver function tests using oral application of a nitrogen compound labelled with 15 N and the subsequent determination of 15 N in a certain fraction of urine or in the total urine by emission spectrometry are described. Because of the key function of the liver in the metabolism of nitrogen compounds, the results of these tests allow conclusions concerning some disturbances of liver functions. (author)

  8. Liver function tests using the stable isotope /sup 15/N

    Energy Technology Data Exchange (ETDEWEB)

    Faust, H; Jung, K; Hirschberg, K; Krumbiegel, P; Junghans, P; Reinhardt, R; Matkowitz, R; Teichmann, B

    1988-01-01

    Several liver function tests using oral application of a nitrogen compound labelled with /sup 15/N and the subsequent determination of /sup 15/N in a certain fraction of urine or in the total urine by emission spectrometry are described. Because of the key function of the liver in the metabolism of nitrogen compounds, the results of these tests allow conclusions concerning some disturbances of liver functions.

  9. Shear wave elastography results correlate with liver fibrosis histology and liver function reserve.

    Science.gov (United States)

    Feng, Yan-Hong; Hu, Xiang-Dong; Zhai, Lin; Liu, Ji-Bin; Qiu, Lan-Yan; Zu, Yuan; Liang, Si; Gui, Yu; Qian, Lin-Xue

    2016-05-07

    To evaluate the correlation of shear wave elastography (SWE) results with liver fibrosis histology and quantitative function reserve. Weekly subcutaneous injection of 60% carbon tetrachloride (1.5 mL/kg) was given to 12 canines for 24 wk to induce experimental liver fibrosis, with olive oil given to 2 control canines. At 24 wk, liver condition was evaluated using clinical biochemistry assays, SWE imaging, lidocaine metabolite monoethylglycine-xylidide (MEGX) test, and histologic fibrosis grading. Clinical biochemistry assays were performed at the institutional central laboratory for routine liver function evaluation. Liver stiffness was measured in triplicate from three different intercostal spaces and expressed as mean liver stiffness modulus (LSM). Plasma concentrations of lidocaine and its metabolite MEGX were determined using high-performance liquid chromatography repeated in duplicate. Liver biopsy samples were fixed in 10% formaldehyde, and liver fibrosis was graded using the modified histological activity index Knodell score (F0-F4). Correlations among histologic grading, LSM, and MEGX measures were analyzed with the Pearson linear correlation coefficient. At 24 wk liver fibrosis histologic grading was as follows: F0, n = 2 (control); F1, n = 0; F2, n = 3; F3, n = 7; and F4, n = 2. SWE LSM was positively correlated with histologic grading (r = 0.835, P function reserve in experimental severe fibrosis and cirrhosis.

  10. 15N liver function tests - concept, validity, clinical use

    International Nuclear Information System (INIS)

    Faust, H.; Jung, K.; Krumbiegel, P.; Hirschberg, K.; Reinhardt, R.; Junghans, P.

    1987-01-01

    Several liver function tests using the oral application of a nitrogen compound labelled with 15 N and the subsequent determination of 15 N in a certain fraction of urine by emission spectrometry are described. Because of the key position of the liver in the metabolism of nitrogen compounds the results of these tests allow conclusions concerning disturbances of special liver functions. Instructions for the clinical use of the '[ 15 N]Ammonium Test', '[ 15 N]Hippurate Test' the '[ 15 N]Methacetin Test', and the '[ 15 N]Glycine Test' are given. (author)

  11. Non-invasive tests in prediction of liver fibrosis in chronic hepatitis B and comparison with post-antiviral treatment results.

    Science.gov (United States)

    Başar, Omer; Yimaz, Bariş; Ekiz, Fuat; Giniş, Zeynep; Altinbaş, Akif; Aktaş, Bora; Tuna, Yaşar; Çoban, Sahin; Delibaş, Namik; Yüksel, Osman

    2013-04-01

    The aim of this study was to assess and compare the performance of a series of non-invasive tests to detect fibrosis in patients with chronic hepatitis B (CHB). Seventy-six patients with CHB, whose blood samples were collected and biopsies were done on the same day, were included in this study. Pre-treatment calculations of aspartate aminotransferase to platelet ratio index (APRI), Forn's index, FIB-4, S-index, Shanghai Liver Fibrosis Group's index (SLFG) and Hepascore(®) were done and relations with mild and advanced fibrosis and cirrhosis were assessed. Post-treatment values of APRI, Forn's index, FIB-4, S-index with oral antiviral agents were also investigated. APRI, S-index, SLFG, FIB-4, Forn's index and Hepascore(®) had 0.669, 0.669, 0.739, 0.741, 0.753, 0.780; retrospectively Area Under the Receiver Operating Characteristic Curve (AUROC) for significant fibrosis. APRI, Forn's index, S-index, FIB-4, SLFG, and Hepascore(®) had 0.681, 0.714, 0.715, 0.738, 0.747, 0.777 retrospectively AUROC for advanced fibrosis. APRI, SLFG, FIB-4, Forn's index, S-index, and Hepascore(®) had 0.741, 0.742, 0.768, 0.779, 0.792, 0.824 retrospectively AUROC for cirrhosis. APRI, Forn's index, FIB-4 and S-index were significantly lower in post-treatment group compared with pre-treatment group (P-values: fibrosis. Our study also suggests that the use of non-invasive test to predict fibrosis in patients with CHB may reduce the need for liver biopsy and may help to monitor the efficacy of treatment. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  12. Oncologic results of laparoscopic liver resection for malignant liver tumors.

    Science.gov (United States)

    Akyuz, Muhammet; Yazici, Pinar; Yigitbas, Hakan; Dural, Cem; Okoh, Alexis; Aliyev, Shamil; Aucejo, Federico; Quintini, Cristiano; Fung, John; Berber, Eren

    2016-02-01

    There are scant data regarding oncologic outcomes of laparoscopic liver resection (LLR). The aim of this study is to analyze the oncologic outcomes of LLR for malignant liver tumors (MLT). This was a prospective IRB-approved study of 123 patients with MLT undergoing LLR. Kaplan-Meier disease-free (DFS) and overall survival (OS) was calculated. Tumor type was colorectal in 61%, hepatocellular cancer in 21%, neuroendocrine in 5% and others in 13%. Mean tumor size was 3.2 ± 1.9 cm and number of tumors 1.6 ± 1.2. A wedge resection or segmentectomy was performed in 63.4%, bisegmentectomy in 24.4%, and hemihepatectomy in 12.2%. Procedures were totally laparoscopic in 67% and hand-assisted in 33%. Operative time was 235.2 ± 94.3 min, and conversion rate 7.3%. An R0 resection was achieved in 90% of patients and 94% of tumors. Median hospital stay was 3 days. Morbidity was 22% and mortality 0.8%. For patients with colorectal liver metastasis, DFS and OS at 2 years was 47% and 88%, respectively. This study shows that LLR is a safe and efficacious treatment for selected patients with MLT. Complete resection and margin recurrence rate are comparable to open series in the literature. © 2015 Wiley Periodicals, Inc.

  13. Quality of Liver and Kideny Function Test

    African Journals Online (AJOL)

    GB

    results for kidney functions and liver functions in. HIV diagnostic and monitoring laboratory are extremely important for decision making with patients under ART programs, and the consequences of erroneous results are huge (8, 9). 1University of Bahir Dar, Biological Inorganic Chemistry, P.O.Box-79, Bahir Dar, Ethiopia.

  14. 131I-BSP liver function test by BSP tolerance

    International Nuclear Information System (INIS)

    Kanda, Koichi

    1974-01-01

    131 I-BSP liver function test after BSP intravenous tolerance was discussed, assuming that the reason why measurements of 131 I-BSP retention rate at 30 minutes and 131 I-BSP disappearance rate in blood showed respectable overlapping between normal group and group with slight liver disorders as compared with BSP test and the reason why differential diagnosis was difficult were due to underestimate of tolerance volume of 131 I-BSP. 131 I-BSP was observed with time as to 70 persons with normal liver function and 257 cases of liver diseases, using 5, 3 and 2 mg of non-radioactive BSP tolerance volume per kilogram of body weight. 131 I-BSP retention rate at 30 minutes and 131 I-BSP disappearance rate in blood are possible to separate overlapping over control in each measurement value at 3-5 mg/kg of tolerance, and in comparison of 3 mg and 5 mg, the latter showed a little excellent result. So, it was decided that tolerance of 3 mg/kg was a proper dose, considering tolerance to liver cells. 131 I-BSP retention rate at 30 minutes was a little excellent in accuracy and disappearance rate in blood after BSP tolerance is simple and profitable for practical use because collection of blood was only one time and measurement could be made with whole blood. As mentioned above, this method is seemed to be useful to practice of liver function test. (Kanao, N.)

  15. The emerging role of transport systems in liver function tests

    NARCIS (Netherlands)

    Stieger, Bruno; Heger, Michal; de Graaf, Wilmar; Paumgartner, Gustav; van Gulik, Thomas

    2012-01-01

    Liver function tests are of critical importance for the management of patients with severe or terminal liver disease. They are also used as prognostic tools for planning liver resections. In recent years many transport systems have been identified that also transport substances employed in liver

  16. Robotic liver surgery: results for 70 resections.

    Science.gov (United States)

    Giulianotti, Pier Cristoforo; Coratti, Andrea; Sbrana, Fabio; Addeo, Pietro; Bianco, Francesco Maria; Buchs, Nicolas Christian; Annechiarico, Mario; Benedetti, Enrico

    2011-01-01

    Robotic surgery is gaining popularity for digestive surgery; however, its use for liver surgery is reported scarcely. This article reviews a surgeon's experience with the use of robotic surgery for liver resections. From March 2002 to March 2009, 70 robotic liver resections were performed at 2 different centers by a single surgeon. The surgical procedure and postoperative outcome data were reviewed retrospectively. Malignant tumors were indications for resections in 42 (60%) patients, whereas benign tumors were indications in 28 (40%) patients. The median age was 60 years (range, 21-84) and 57% of patients were female. Major liver resections (≥ 3 liver segments) were performed in 27 (38.5%) patients. There were 4 conversions to open surgery (5.7%). The median operative time for a major resection was 313 min (range, 220-480) and 198 min (range, 90-459) for minor resection. The median blood loss was 150 mL (range, 20-1,800) for minor resection and 300 mL (range, 100-2,000) for major resection. The mortality rate was 0%, and the overall rate of complications was 21%. Major morbidity occurred in 4 patients in the major hepatectomies group (14.8%) and in 4 patients in the minor hepatectomies group (9.3%). All complications were managed conservatively and none required reoperation. This preliminary experience shows that robotic surgery can be used safely for liver resections with a limited conversion rate, blood loss, and postoperative morbidity. Robotics offers a new technical option for minimally invasive liver surgery. Copyright © 2011 Mosby, Inc. All rights reserved.

  17. Safety and Yield of Diagnostic ERCP in Liver Transplant Patients with Abnormal Liver Function Tests

    Directory of Open Access Journals (Sweden)

    Jayapal Ramesh

    2014-01-01

    Full Text Available Background. Abnormal liver enzymes postorthotopic liver transplant (OLT may indicate significant biliary pathology or organ rejection. There is very little known in the literature regarding the current role of diagnostic ERCP in this scenario. Aim. To review the utility of diagnostic ERCP in patients presenting with abnormal liver function tests in the setting of OLT. Methods. A retrospective review of diagnostic ERCPs in patients with OLT from 2002 to 2013 from a prospectively maintained, IRB approved database. Results. Of the 474 ERCPs performed in OLT patients, 210 (44.3%; 95% CI 39.8–48.8 were performed for abnormal liver function tests during the study period. Majority of patients were Caucasian (83.8%, male (62.4% with median age of 55 years (IQR 48–62 years. Biliary cannulation was successful in 99.6% of cases and findings included stricture in 45 (21.4 %; biliary stones/sludge in 23 (11%; biliary dilation alone in 31 (14.8%; and normal in 91 (43.3%. Three (1.4% patients developed mild, self-limiting pancreatitis; one patient (0.5% developed cholangitis and two (1% had postsphincterotomy bleeding. Multivariate analyses showed significant association between dilated ducts on imaging with a therapeutic outcome. Conclusion. Diagnostic ERCP in OLT patients presenting with liver function test abnormalities is safe and frequently therapeutic.

  18. Climax granite test results

    Energy Technology Data Exchange (ETDEWEB)

    Ramspott, L.D.

    1980-01-15

    The Lawrence Livermore Laboratory (LLL), as part of the Nevada Nuclear Waste Storage Investigations (NNWSI) program, is carrying out in situ rock mechanics testing in the Climax granitic stock at the Nevada Test Site (NTS). This summary addresses only those field data taken to date that address thermomechanical modeling for a hard-rock repository. The results to be discussed include thermal measurements in a heater test that was conducted from October 1977 through July 1978, and stress and displacement measurements made during and after excavation of the canister storage drift for the Spent Fuel Test (SFT) in the Climax granite. Associated laboratory and field measurements are summarized. The rock temperature for a given applied heat load at a point in time and space can be adequately modeled with simple analytic calculations involving superposition and integration of numerous point source solutions. The input, for locations beyond about a meter from the source, can be a constant thermal conductivity and diffusivity. The value of thermal conductivity required to match the field data is as much as 25% different from laboratory-measured values. Therefore, unless we come to understand the mechanisms for this difference, a simple in situ test will be required to obtain a value for final repository design. Some sensitivity calculations have shown that the temperature field is about ten times more sensitive to conductivity than to diffusivity under the test conditions. The orthogonal array was designed to detect anisotropy. After considering all error sources, anisotropic efforts in the thermal field were less than 5 to 10%.

  19. Guidelines on the management of abnormal liver blood tests

    Science.gov (United States)

    Cramb, Rob; Davison, Suzanne M; Dillon, John F; Foulerton, Mark; Godfrey, Edmund M; Hall, Richard; Harrower, Ulrike; Hudson, Mark; Langford, Andrew; Mackie, Anne; Mitchell-Thain, Robert; Sennett, Karen; Sheron, Nicholas C; Verne, Julia; Walmsley, Martine; Yeoman, Andrew

    2018-01-01

    These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines, which this document supersedes, were written in 2000 and have undergone extensive revision by members of the Guidelines Development Group (GDG). The GDG comprises representatives from patient/carer groups (British Liver Trust, Liver4life, PBC Foundation and PSC Support), elected members of the BSG liver section (including representatives from Scotland and Wales), British Association for the Study of the Liver (BASL), Specialist Advisory Committee in Clinical Biochemistry/Royal College of Pathology and Association for Clinical Biochemistry, British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN), Public Health England (implementation and screening), Royal College of General Practice, British Society of Gastrointestinal and Abdominal Radiologists (BSGAR) and Society of Acute Medicine. The quality of evidence and grading of recommendations was appraised using the AGREE II tool. These guidelines deal specifically with the management of abnormal liver blood tests in children and adults in both primary and secondary care under the following subheadings: (1) What constitutes an abnormal liver blood test? (2) What constitutes a standard liver blood test panel? (3) When should liver blood tests be checked? (4) Does the extent and duration of abnormal liver blood tests determine subsequent investigation? (5) Response to abnormal liver blood tests. They are not designed to deal with the management of the underlying liver disease. PMID:29122851

  20. Pressure locking test results

    Energy Technology Data Exchange (ETDEWEB)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  1. Pressure locking test results

    International Nuclear Information System (INIS)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D.

    1996-01-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, open-quotes Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.close quotes Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; we will publish the results of our thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions

  2. Change of liver echogenicity in chronic renal failure: Correlation with serologic test and pathologic findings

    International Nuclear Information System (INIS)

    Eun, Hyo Won; Cho, Kyoung Sik; Kim, Jeong Kon; Kim, Jung Hoon

    2002-01-01

    To correlate serologic test and pathologic findings with change of hepatic parenchymal echogenicity on ultrasound (US) in patients with chronic renal failure. From January 1995 to April 2000, among eight hundred eighty four patients with kidney transplantation due to chronic renal failure, sixty seven patients who underwent US-guided liver biopsy were selected. Change of liver echogenicity on US was analyzed, and this change was compared with serologic test and pathologic findings. Among sixty seven patients, pathologic findings of thirty four patients with the normal liver echogenicity on US revealed normal in 15 patients (44%), viral hepatitis in 18 (53%), and liver cirrhosis in one patient (3%). Meanwhile, twenty seven patients with chronic liver disease on US were pathologically confirmed as normal in 13 patients (48%), viral hepatitis in 11 (40%), liver cirrhosis in four patients (11%); six patients with cirrhotic change on US, liver cirrhosis in four patients (67%) and viral hepatitis on two patients (33%). Serologic test of thirty four patients with the normal liver echogenicity on US showed positive HBs Ag in 17 patients (50%), positive anti-HCV Ab in 11 (32%), positive in both HBs Ag and anti-HCV Ab in one (3%), and normal result in five patients (15%). In patients with chronic renal failure, it is nor enough to determine the presence of liver disease only based on change of echogenicity on US. A careful correlation with serologic test and, if needed, pathologic confirmation are recommended for the accurate preoperative evaluation of the liver.

  3. Comparison of rapid diagnostic tests to detect Mycobacterium avium subsp. paratuberculosis disseminated infection in bovine liver.

    Science.gov (United States)

    Zarei, Mehdi; Ghorbanpour, Masoud; Tajbakhsh, Samaneh; Mosavari, Nader

    2017-08-01

    Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease, a chronic enteritis in cattle and other domestic and wild ruminants. The presence of MAP in tissues other than intestines and associated lymph nodes, such as meat and liver, is a potential public health concern. In the present study, the relationship between the results of rapid diagnostic tests of the Johne's disease, such as serum ELISA, rectal scraping PCR, and acid-fast staining, and the presence of MAP in liver was evaluated. Blood, liver, and rectal scraping samples were collected from 200 slaughtered cattle with unknown Johne's disease status. ELISA was performed to determine the MAP antibody activity in the serum. Acid-fast staining was performed on rectal scraping samples, and PCR was performed on rectal scraping and liver samples. PCR-positive liver samples were used for mycobacterial culture. Overall, the results of this study demonstrated that MAP can be detected and cultured from liver of slaughtered cattle and rapid diagnostic tests of Johne's disease have limited value in detecting cattle with MAP infection in liver. These findings show that the presence of MAP in liver tissue may occur in cows with negative results for rapid diagnostic tests and vice versa. Hence, liver might represent another possible risk of human exposure to MAP. Given concerns about a potential zoonotic role for MAP, these results show the necessity to find new methods for detecting cattle with MAP disseminated infection.

  4. Hepatobiliary magnetic resonance imaging in patients with liver disease: correlation of liver enhancement with biochemical liver function tests

    Energy Technology Data Exchange (ETDEWEB)

    Kukuk, Guido M.; Schaefer, Stephanie G.; Hadizadeh, Dariusch R.; Schild, Hans H.; Willinek, Winfried A. [University of Bonn, Department of Radiology, Bonn (Germany); Fimmers, Rolf [University of Bonn, Department of Medical Biometry, Informatics and Epidemiology, Bonn (Germany); Ezziddin, Samer [Department of Nuclear Medicine, Bonn (Germany); Spengler, Ulrich [Department of Internal Medicine I, Bonn (Germany)

    2014-10-15

    To evaluate hepatobiliary magnetic resonance imaging (MRI) using Gd-EOB-DTPA in relation to various liver function tests in patients with liver disorders. Fifty-one patients with liver disease underwent Gd-EOB-DTPA-enhanced liver MRI. Based on region-of-interest (ROI) analysis, liver signal intensity was calculated using the spleen as reference tissue. Liver-spleen contrast ratio (LSCR) and relative liver enhancement (RLE) were calculated. Serum levels of total bilirubin, gamma glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH), lactate dehydrogenase (LDH), serum albumin level (AL), prothrombin time (PT), creatinine (CR) as well as international normalised ratio (INR) and model for end-stage liver disease (MELD) score were tested for correlation with LSCR and RLE. Pre-contrast LSCR values correlated with total bilirubin (r = -0.39; p = 0.005), GGT (r = -0.37; p = 0.009), AST (r = -0.38; p = 0.013), ALT (r = -0.29; p = 0.046), PT (r = 0.52; p < 0.001), GLDH (r = -0.55; p = 0.044), INR (r = -0.42; p = 0.003), and MELD Score (r = -0.53; p < 0.001). After administration of Gd-EOB-DTPA bilirubin (r = -0.45; p = 0.001), GGT (r = -0.40; p = 0.004), PT (r = 0.54; p < 0.001), AST (r = -0.46; p = 0.002), ALT (r = -0.31; p = 0.030), INR (r = -0.45; p = 0.001) and MELD Score (r = -0.56; p < 0.001) significantly correlated with LSCR. RLE correlated with bilirubin (r = -0.40; p = 0.004), AST (r = -0.38; p = 0.013), PT (r = 0.42; p = 0.003), GGT (r = -0.33; p = 0.020), INR (r = -0.36; p = 0.011) and MELD Score (r = -0.43; p = 0.003). Liver-spleen contrast ratio and relative liver enhancement using Gd-EOB-DTPA correlate with a number of routinely used biochemical liver function tests, suggesting that hepatobiliary MRI may serve as a valuable biomarker for liver function. The strongest correlation with liver enhancement was found for the MELD Score. (orig.)

  5. CCTF CORE I test results

    International Nuclear Information System (INIS)

    Murao, Yoshio; Sudoh, Takashi; Akimoto, Hajime; Iguchi, Tadashi; Sugimoto, Jun; Fujiki, Kazuo; Hirano, Kenmei

    1982-07-01

    This report presents the results of the following CCTF CORE I tests conducted in FY. 1980. (1) Multi-dimensional effect test, (2) Evaluation model test, (3) FLECHT coupling test. On the first test, one-dimensional treatment of the core thermohydrodynamics was discussed. On the second and third tests, the test results were compared with the results calculated by the evaluation model codes and the results of the corresponding FLECHT-SET test (Run 2714B), respectively. The work was performed under contracts with the Atomic Energy Bureau of Science and Technology Agency of Japan. (author)

  6. Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study.

    Science.gov (United States)

    Lee, Karla C L; Baker, Luisa A; Stanzani, Giacomo; Alibhai, Hatim; Chang, Yu Mei; Jimenez Palacios, Carolina; Leckie, Pamela J; Giordano, Paola; Priestnall, Simon L; Antoine, Daniel J; Jenkins, Rosalind E; Goldring, Christopher E; Park, B Kevin; Andreola, Fausto; Agarwal, Banwari; Mookerjee, Rajeshwar P; Davies, Nathan A; Jalan, Rajiv

    2015-09-01

    In acute liver failure, severity of liver injury and clinical progression of disease are in part consequent upon activation of the innate immune system. Endotoxaemia contributes to innate immune system activation and the detoxifying function of albumin, critical to recovery from liver injury, is irreversibly destroyed in acute liver failure. University College London-Liver Dialysis Device is a novel artificial extracorporeal liver assist device, which is used with albumin infusion, to achieve removal and replacement of dysfunctional albumin and reduction in endotoxaemia. We aimed to test the effect of this device on survival in a pig model of acetaminophen-induced acute liver failure. Pigs were randomised to three groups: Acetaminophen plus University College London-Liver Dialysis Device (n=9); Acetaminophen plus Control Device (n=7); and Control plus Control Device (n=4). Device treatment was initiated two h after onset of irreversible acute liver failure. The Liver Dialysis Device resulted in 67% reduced risk of death in acetaminophen-induced acute liver failure compared to Control Device (hazard ratio=0.33, p=0.0439). This was associated with 27% decrease in circulating irreversibly oxidised human non-mercaptalbumin-2 throughout treatment (p=0.046); 54% reduction in overall severity of endotoxaemia (p=0.024); delay in development of vasoplegia and acute lung injury; and delay in systemic activation of the TLR4 signalling pathway. Liver Dialysis Device-associated adverse clinical effects were not seen. The survival benefit and lack of adverse effects would support clinical trials of University College London-Liver Dialysis Device in acute liver failure patients. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  7. Pheochromocytoma with Markedly Abnormal Liver Function Tests and Severe Leukocytosis

    Directory of Open Access Journals (Sweden)

    Chai Ryoung Eun

    2014-03-01

    Full Text Available Pheochromocytoma is a rare neuroendocrine tumor arising from the medulla of the adrenal glands, which causes an overproduction of catecholamines. The common symptoms are headache, palpitations, and sweating; however, various other clinical manifestations might also be present. Accurate diagnosis of pheochromocytoma is important because surgical treatment is usually successful, and associated clinical problems are reversible if treated early. A 49-year-old man with a history of uncontrolled hypertension and diabetes mellitus presented with chest pain, fever, and sweating. His liver function tests and white blood cell counts were markedly increased and his echocardiography results suggested stress-induced cardiomyopathy. His abdominal computed tomography showed a 5×5-cm-sized tumor in the left adrenal gland, and laboratory tests confirmed catecholamine overproduction. After surgical resection of the left adrenal gland, his liver function tests and white blood cell counts normalized, and echocardiography showed normal cardiac function. Moreover, his previous antihypertensive regimen was deescalated, and his previously uncontrolled blood glucose levels normalized without medication.

  8. Comparative Study of Human Liver Ferritin and Chicken Liver by Moessbauer Spectroscopy. Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Oshtrakh, M. I. [Ural State Technical University - UPI, Division of Applied Biophysics, Faculty of Physical Techniques and Devices for Quality Control (Russian Federation); Milder, O. B.; Semionkin, V. A. [Ural State Technical University - UPI, Faculty of Experimental Physics (Russian Federation); Prokopenko, P. G. [Russian State Medical University, Faculty of Biochemistry (Russian Federation); Malakheeva, L. I. [Simbio Holding, Science Consultation Department (Russian Federation)

    2004-12-15

    A comparative study of normal human liver ferritin and livers from normal chicken and chicken with Marek disease was made by Moessbauer spectroscopy. Small differences of quadrupole splitting and isomer shift were found for human liver ferritin and chicken liver. Moessbauer parameters for liver from normal chicken and chicken with Marek disease were the same.

  9. Comparative Study of Human Liver Ferritin and Chicken Liver by Moessbauer Spectroscopy. Preliminary Results

    International Nuclear Information System (INIS)

    Oshtrakh, M. I.; Milder, O. B.; Semionkin, V. A.; Prokopenko, P. G.; Malakheeva, L. I.

    2004-01-01

    A comparative study of normal human liver ferritin and livers from normal chicken and chicken with Marek disease was made by Moessbauer spectroscopy. Small differences of quadrupole splitting and isomer shift were found for human liver ferritin and chicken liver. Moessbauer parameters for liver from normal chicken and chicken with Marek disease were the same.

  10. A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane, 3

    International Nuclear Information System (INIS)

    Hazama, Hiroshi; Kawa, Soukichi; Kubota, Yoshitsugu

    1986-01-01

    We evaluated the vilidity of a new liver function test using liver scintigraphy based on the asialoglycoprotein (ASGP) receptor system on the liver cell membrane in rats with galactosamine-induced acute liver disorder and those with carbon tetra-chloride-induced chronic liver disorder. Neoglycoprotein (GHSA) produced by combining human serum albumin with 32 galactose units was labeled with 99m Tc and administered (50 μg/100 g body weight) to rats with acute or chronic liver disorder. Clearance curves were produced based on liver scintigrams and analysed using the two-compartment model to obtain parameters. In acute liver disorder, the prolongation of 99m Tc-GHSA clearance and the decrease in ASGP receptor activities correlated well to the increase in serum GOT and the decrease in the esterified to total cholesterol ratio (E/T ratio); in chronic liver disorder, they correlated significantly to the increase in the content of liver hydroxyproline (Hyp) which increased in proportion to the severity of liver fibrosis studied histologically, and to the decrease in the contents of cytochrome P-450 and cytochrome b 5 in liver microsomes. Significant correlation was observed between the prolongation of 99m Tc-GHSA clearance and the decrease in ASGP receptor activities in both acute and chronic liver disorders. These findings indicate that the measurement of 99m Tc-GHSA clearance can be a new liver function test sensitively reflecting the severity of liver damage. (author)

  11. MITG test procedure and results

    International Nuclear Information System (INIS)

    Eck, M.E.; Mukunda, M.

    1983-01-01

    Elements and modules for Radioisotope Thermoelectric Generator have been performance tested since the inception of the RTG program. These test articles seldom resembled flight hardware and often lacked adequate diagnostic instrumentation. Because of this, performance problems were not identified in the early stage of program development. The lack of test data in an unexpected area often hampered the development of a problem solution. A procedure for conducting the MITG Test was developed in an effort to obtain data in a systematic, unambiguous manner. This procedure required the development of extensive data acquisition software and test automation. The development of a facility to implement the test procedure, the facility hardware and software requirements, and the results of the MITG testing are the subject of this paper

  12. Percutaneous debridement of complex pyogenic liver abscesses: technique and results

    International Nuclear Information System (INIS)

    Morettin, L.B.

    1992-01-01

    The author's approach and technique in the treatment of complex liver abscesses that persisted or recurred following percutaneous drainage are described. Six patients were treated by percutaneous debridement utilizing an instrument specifically constructed for that purpose. Four patients were chronically ill but stable. Two patients were septic, hypotensive and considered life threatened. All patients had primary pyogenic abscesses. Four had demonstrated mixed bacterial flora consisting of E. coli, Klebsiella, Proteus and gram-positive cocci and two were caused by E. coli only. In all cases a contrast-enhanced CT of the abdomen revealed multiloculated or septated abscesses containing large central debris and peripheral shell or halo of compromised hepatic parenchyma. Debridement was successful in all cases resulting in complete healing in 4-12 days. Follow-up for periods of between 1 and 4.5 years revealed no recurrences. Three cases of infected tumors of the liver were referred for treatment. CT findings in these cases demonstrated a well-developed external capsule and internal septations and the absence of a surrounding halo of compromised parenchyma distinguishes them from primary abscesses. This preliminary experience allows the conclusion that percutaneous debridement of pyogenic liver abscesses can be safely performed, can be curative in selected patients with chronic abscesses and may be life-safing in critically ill and life-threatened patients. (orig.)

  13. Engineering model cryocooler test results

    International Nuclear Information System (INIS)

    Skimko, M.A.; Stacy, W.D.; McCormick, J.A.

    1992-01-01

    This paper reports that recent testing of diaphragm-defined, Stirling-cycle machines and components has demonstrated cooling performance potential, validated the design code, and confirmed several critical operating characteristics. A breadboard cryocooler was rebuilt and tested from cryogenic to near-ambient cold end temperatures. There was a significant increase in capacity at cryogenic temperatures and the performance results compared will with code predictions at all temperatures. Further testing on a breadboard diaphragm compressor validated the calculated requirement for a minimum axial clearance between diaphragms and mating heads

  14. Prevalence of abnormal liver function tests in rheumatoid arthritis ...

    African Journals Online (AJOL)

    Objective: To determine the prevalence of Abnormal Liver Function Tests (LFTs) in patients with rheumatoid arthritis at the rheumatology out-patient clinic, Kenyatta National Hospital (KNH). Design: Cross-sectional descriptive study. Setting: Rheumatology out-patient clinic at KNH. Participants: One hundred and seven RA ...

  15. Quality of Liver and Kidney Function Tests among Public Medical ...

    African Journals Online (AJOL)

    The aim of this study is to assess the accuracy and precision of clinical chemistry laboratories in western region of Amhara national regional state of Ethiopia in testing liver and kidney functions. Methods: Eight laboratories in hospitals and a Regional Health Research Laboratory Center participated in this study from ...

  16. Quality of Liver and Kideny Function Test

    African Journals Online (AJOL)

    GB

    2013-07-02

    Jul 2, 2013 ... ... of data gathering. RESULTS: Students' stress level and associated MSDs were higher during the examination period ... and teachers and financial hardship(3). ..... reticular formation, and immune system .... among students engaged in education programs .... musculoskeletal disorders among Brazilian.

  17. Prognostic durability of liver fibrosis tests and improvement in predictive performance for mortality by combining tests.

    Science.gov (United States)

    Bertrais, Sandrine; Boursier, Jérôme; Ducancelle, Alexandra; Oberti, Frédéric; Fouchard-Hubert, Isabelle; Moal, Valérie; Calès, Paul

    2017-06-01

    There is currently no recommended time interval between noninvasive fibrosis measurements for monitoring chronic liver diseases. We determined how long a single liver fibrosis evaluation may accurately predict mortality, and assessed whether combining tests improves prognostic performance. We included 1559 patients with chronic liver disease and available baseline liver stiffness measurement (LSM) by Fibroscan, aspartate aminotransferase to platelet ratio index (APRI), FIB-4, Hepascore, and FibroMeter V2G . Median follow-up was 2.8 years during which 262 (16.8%) patients died, with 115 liver-related deaths. All fibrosis tests were able to predict mortality, although APRI (and FIB-4 for liver-related mortality) showed lower overall discriminative ability than the other tests (differences in Harrell's C-index: P fibrosis, 1 year in patients with significant fibrosis, and liver disease (MELD) score testing sets. In the training set, blood tests and LSM were independent predictors of all-cause mortality. The best-fit multivariate model included age, sex, LSM, and FibroMeter V2G with C-index = 0.834 (95% confidence interval, 0.803-0.862). The prognostic model for liver-related mortality included the same covariates with C-index = 0.868 (0.831-0.902). In the testing set, the multivariate models had higher prognostic accuracy than FibroMeter V2G or LSM alone for all-cause mortality and FibroMeter V2G alone for liver-related mortality. The prognostic durability of a single baseline fibrosis evaluation depends on the liver fibrosis level. Combining LSM with a blood fibrosis test improves mortality risk assessment. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  18. Summary of CCTF test results

    International Nuclear Information System (INIS)

    Iguchi, T.; Murao, Y.; Sugimoto, J.; Akimoto, H.; Okubo, T.; Hojo, T.

    1987-01-01

    Conservatism of current safety analysis was assessed by comparing the predicted result with cylindrical core test facility (CCTF) test result performed at Japan Atomic Energy Research Institute. WREM code was selected for the assessment. The overall conservatism of the WREM code on the peak clad temperature prediction was confirmed against CCTF evaluation model (EM) test which simulated the typical initial and boundary conditions in the safety evaluation analysis. WREM code predicted the reasonable core boundary conditions and the conservatism of the code came mainly from core calculation. The conservatism of the WREM code against CCTF data could be attributed to the following three points: (1) no horizontal mixing assumption between subchannels at each elevation; (2) no modeling on heat transfer enhancement caused by the radial core power profile; and (3) conservative heat transfer correlations in the code

  19. Mobile evaporator corrosion test results

    International Nuclear Information System (INIS)

    Rozeveld, A.; Chamberlain, D.B.

    1997-05-01

    Laboratory corrosion tests were conducted on eight candidates to select a durable and cost-effective alloy for use in mobile evaporators to process radioactive waste solutions. Based on an extensive literature survey of corrosion data, three stainless steel alloys (304L, 316L, AL-6XN), four nickel-based alloys (825, 625, 690, G-30), and titanium were selected for testing. The corrosion tests included vapor phase, liquid junction (interface), liquid immersion, and crevice corrosion tests on plain and welded samples of candidate materials. Tests were conducted at 80 degrees C for 45 days in two different test solutions: a nitric acid solution. to simulate evaporator conditions during the processing of the cesium ion-exchange eluant and a highly alkaline sodium hydroxide solution to simulate the composition of Tank 241-AW-101 during evaporation. All of the alloys exhibited excellent corrosion resistance in the alkaline test solution. Corrosion rates were very low and localized corrosion was not observed. Results from the nitric acid tests showed that only 316L stainless steel did not meet our performance criteria. The 316L welded interface and crevice specimens had rates of 22.2 mpy and 21.8 mpy, respectively, which exceeds the maximum corrosion rate of 20 mpy. The other welded samples had about the same corrosion resistance as the plain samples. None of the welded samples showed preferential weld or heat-affected zone (HAZ) attack. Vapor corrosion was negligible for all alloys. All of the alloys except 316L exhibited either open-quotes satisfactoryclose quotes (2-20 mpy) or open-quotes excellentclose quotes (<2 mpy) corrosion resistance as defined by National Association of Corrosion Engineers. However, many of the alloys experienced intergranular corrosion in the nitric acid test solution, which could indicate a susceptibility to stress corrosion cracking (SCC) in this environment

  20. Results of simultaneous and sequential pediatric liver and kidney transplantation.

    Science.gov (United States)

    Rogers, J; Bueno, J; Shapiro, R; Scantlebury, V; Mazariegos, G; Fung, J; Reyes, J

    2001-11-27

    The indications for simultaneous and sequential pediatric liver (LTx) and kidney (KTx) transplantation have not been well defined. We herein report the results of our experience with these procedures in children with end-stage liver disease and/or subsequent end-stage renal disease. Between 1984 and 1995, 12 LTx recipients received 15 kidney allografts. Eight simultaneous and seven sequential LTx/KTx were performed. There were six males and six females, with a mean age of 10.9 years (1.5-23.7). One of the eight simultaneous LTx/KTx was part of a multivisceral allograft. Five KTx were performed at varied intervals after successful LTx, one KTx was performed after a previous simultaneous LTx/KTx, and one KTx was performed after previous sequential LTx/KTx. Immunosuppression was with tacrolimus or cyclosporine and steroids. Indications for LTx were oxalosis (four), congenital hepatic fibrosis (two), cystinosis (one), polycystic liver disease (one), A-1-A deficiency (one), Total Parenteral Nutrition (TPN)-related (one), cryptogenic cirrhosis (one), and hepatoblastoma (one). Indications for KTx were oxalosis (four), drug-induced (four), polycystic kidney disease (three), cystinosis (one), and glomerulonephritis (1). With a mean follow-up of 58 months (0.9-130), the overall patient survival rate was 58% (7/12). One-year and 5-year actuarial patient survival rates were 66% and 58%, respectively. Patient survival rates at 1 year after KTx according to United Network of Organ Sharing (liver) status were 100% for status 3, 50% for status 2, and 0% for status 1. The overall renal allograft survival rate was 47%. Actuarial renal allograft survival rates were 53% at 1 and 5 years. The overall hepatic allograft survival rate was equivalent to the overall patient survival rate (58%). Six of seven surviving patients have normal renal allograft function, and one patient has moderate chronic allograft nephropathy. All surviving patients have normal hepatic allograft function. Six

  1. Evaluation of Factors Influencing Liver Function Test in On-Pump Coronary Artery Bypass Graft Surgery

    Directory of Open Access Journals (Sweden)

    Shahrbano Shahbazi

    2013-12-01

    Full Text Available Background: Liver dysfunction during on-pump coronary artery bypass graft surgery (CABG is a rare complication but is associated with significant morbidity and mortality. The ability to identify high-risk patients may be helpful in planning appropriate management strategies. We aimed to evaluate the factors influencing liver function tests during on-pump CABG. Methods: In 146 patients scheduled for on-pump CABG, the liver function test was done preoperatively and on the first postoperative day. Some preoperative and intraoperative risk factors were checked and then the postoperative liver function tests were compared with the preoperative ones. Probable relationships between these changes and the preoperative and intraoperative risk factors were studied. Results: A medical history of diabetes had a significant relationship with the changes in direct bilirubin. Preoperative central venous pressure had a significant relationship with the changes in aspartate aminotransferase and alanine aminotransferase. Use of intra-aortic balloon pump and duration of aortic cross-clamp were significantly related to the changes in the liver function tests except for alanine aminotransferase and alkaline phosphatase. Conclusion: It seems that the techniques for the reduction of cardiopulmonary bypass and aortic cross-clamp duration may be useful to protect liver function. We recommend that a larger population of patients be studied to confirm these findings.

  2. Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.

    Science.gov (United States)

    Halfon, Philippe; Bacq, Yannick; De Muret, Anne; Penaranda, Guillaume; Bourliere, Marc; Ouzan, Denis; Tran, Albert; Botta, Danielle; Renou, Christophe; Bréchot, Marie-Claude; Degott, Claude; Paradis, Valérie

    2007-03-01

    We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT), APRI, FibroMeter (FM), and Hepascore (HS). Metavir stages were: F0: 4%, F1: 55%, F2: 26%, F3: 11%, and F4: 4%. The AUROCs were not significantly different, respectively, FT, FM, APRI, HS: >or=F2: 0.79, 0.78, 0.76, >or=0.76; F3: 0.81, 0.85, 0.81, 0.81; and F4: 0.86, 0.94, 0.92, 0.89. The TPP relies on the paired comparison of blood-test misclassification based on liver specimen, e.g. FT vs FM, respectively: F0+1: 18 vs 28% (p=0.0003), >or=F2: 43 vs 31% (p=0.004). There was no center effect. In those populations, the four blood tests had a similar performance for significant fibrosis (F>or=2), lying in the lower range of published results which is attributable to a low >or=F2 prevalence, and for >or=F3 and F4. However, FM and FT had performance profiles significantly different as a function of fibrosis stages or diagnostic target (fibrosis cut-off). This has to be considered during the interpretation process. Moreover, the performance should be reported with different diagnostic targets.

  3. Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.

    Science.gov (United States)

    Thiele, Maja; Madsen, Bjørn Stæhr; Hansen, Janne Fuglsang; Detlefsen, Sönke; Antonsen, Steen; Krag, Aleksander

    2018-04-01

    Alcohol is the leading cause of cirrhosis and liver-related mortality, but we lack serum markers to detect compensated disease. We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the FibroTest, liver stiffness measurements (made by transient elastography and 2-dimensional shear-wave elastography), and 6 indirect marker tests in detection of advanced liver fibrosis (Kleiner stage ≥F3). We performed a prospective study of 10 liver fibrosis markers (patented and not), all performed on the same day. Patients were recruited from primary centers (municipal alcohol rehabilitation, n = 128; 6% with advanced fibrosis) and secondary health care centers (hospital outpatient clinics, n = 161; 36% with advanced fibrosis) in the Region of Southern Denmark from 2013 through 2016. Biopsy-verified fibrosis stage was used as the reference standard. The primary aim was to validate ELF in detection of advanced fibrosis in patients with alcoholic liver disease recruited from primary and secondary health care centers, using the literature-based cutoff value of 10.5. Secondary aims were to assess the diagnostic accuracy of ELF for significant fibrosis and cirrhosis and to determine whether combinations of fibrosis markers increase diagnostic yield. The ELF identified patients with advanced liver fibrosis with an area under the receiver operating characteristic curve (AUROC) of 0.92 (95% confidence interval 0.89-0.96); findings did not differ significantly between patients from primary vs secondary care (P = .917). ELF more accurately identified patients with advanced liver fibrosis than indirect marker tests, but ELF and FibroTest had comparable diagnostic accuracies (AUROC of FibroTest, 0.90) (P = .209 for comparison with ELF). Results from the ELF and FibroTest did not differ significantly from those of liver stiffness measurement in intention-to-diagnose analyses (AUROC for transient elastography, 0.90), but did differ in the per-protocol analysis (AUROC for

  4. FibroMeters: a family of blood tests for liver fibrosis.

    Science.gov (United States)

    Calès, P; Boursier, J; Oberti, F; Hubert, I; Gallois, Y; Rousselet, M-C; Dib, N; Moal, V; Macchi, L; Chevailler, A; Michalak, S; Hunault, G; Chaigneau, J; Sawadogo, A; Lunel, F

    2008-09-01

    FibroMeters are blood tests for liver fibrosis with several specificities: two main diagnostic targets (fibrosis stage and area of fibrosis); adaptation to specific causes; and results confirmed by an expert system. Thus, FibroMeters comprise six different tests: one for staging and one for quantitation of liver fibrosis in each of the three main causes of chronic liver disease-chronic viral hepatitis, alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). FibroMeters display a high overall diagnostic accuracy and are the only tests to correctly classify 100% of HCV patients without fibrosis or with cirrhosis. They have 90% predictive values in a higher proportion of patients than with other usual blood tests. A 90% correct classification is available in 100% of HCV patients with the following reliable diagnostic intervals: F0/1, F1/2, F2+/-1, F3+/-1. In real-life conditions, the reproducibility of FibroMeters is higher than that of liver biopsy or ultrasonographic elastometry. FibroMeters are robust tests with the most stable diagnostic performance across different centers. Optional tests are also available, such as a specific one for cirrhosis, which has a diagnostic accuracy of 93.0% (AUROC: 0.92) and a 100% positive predictive value for diagnosis of HCV cirrhosis. Determination by FibroMeters of the area of fibrosis - the only direct, non-invasive, quantitative measurement of liver fibrosis - are especially useful for following-up cirrhosis as it correlates well with clinical events. FibroMeters are also very accurate in HVB or HIV-HCV co-infected patients. The tests specific for ALD and NAFLD also have a high diagnostic accuracy (AUROCs: 0.96 and 0.94, respectively, for significant fibrosis).

  5. Evaluating the RELM Test Results

    Directory of Open Access Journals (Sweden)

    Michael K. Sachs

    2012-01-01

    Full Text Available We consider implications of the Regional Earthquake Likelihood Models (RELM test results with regard to earthquake forecasting. Prospective forecasts were solicited for M≥4.95 earthquakes in California during the period 2006–2010. During this period 31 earthquakes occurred in the test region with M≥4.95. We consider five forecasts that were submitted for the test. We compare the forecasts utilizing forecast verification methodology developed in the atmospheric sciences, specifically for tornadoes. We utilize a “skill score” based on the forecast scores λfi of occurrence of the test earthquakes. A perfect forecast would have λfi=1, and a random (no skill forecast would have λfi=2.86×10-3. The best forecasts (largest value of λfi for the 31 earthquakes had values of λfi=1.24×10-1 to λfi=5.49×10-3. The best mean forecast for all earthquakes was λ̅f=2.84×10-2. The best forecasts are about an order of magnitude better than random forecasts. We discuss the earthquakes, the forecasts, and alternative methods of evaluation of the performance of RELM forecasts. We also discuss the relative merits of alarm-based versus probability-based forecasts.

  6. EFTF cobalt test assembly results

    International Nuclear Information System (INIS)

    Rawlins, J.A.; Wootan, D.W.; Carter, L.L.; Brager, H.R.; Schenter, R.E.

    1988-01-01

    A cobalt test assembly containing yttrium hydride pins for neutron moderation was irradiated in the Fast Flux Test Facility during Cycle 9A for 137.7 equivalent full power days at a power level fo 291 MW. The 36 test pins consisted of a batch of 32 pins containing cobalt metal to produce Co-60, and a set of 4 pins with europium oxide to produce Gd-153, a radioisotope used in detection of the bone disease Osteoporosis. Post-irradiation examination of the cobalt pins determined the Co-60 produced with an accuracy of about 5 %. The measured Co-60 spatially distributed concentrations were within 20 % of the calculated concentrations. The assembly average Co-60 measured activity was 4 % less than the calculated value. The europium oxide pins were gamma scanned for the europium isotopes Eu-152 and Eu-154 to an absolute accuracy of about 10 %. The measured europium radioisotpe anc Gd-153 concentrations were within 20 % of calculated values. In conclusion, the hydride assembly performed well and is an excellent vehicle for many Fast Flux Test Facility isotope production applications. The results also demonstrate that the calculational methods developed by the Westinghouse Hanford Company are very accurate. (author)

  7. Liver cirrhosis as a result of chronic hepatitis C

    Directory of Open Access Journals (Sweden)

    A. A. Sukhoruk

    2014-01-01

    Full Text Available The incidence of chronic hepatitis C in St. Petersburg is 124.4 per 100 000 population. The number of patients with liver cirrhosis is significant.Aim of this study: to examine the demographic, clinical and epidemiological characteristics of patients with cirrhosis in the results of chronic hepatitis C.Materials and methods: 100 patients with cirrhosis due to chronic hepatitis C in age 31–70 years were included. Patients with infection hepatitis viruses A and B, HIV, alcohol abuse, drug addicts, previously received antiviral therapy were excluded. Liver cirrhosis was diagnosed on the basis clinical, laboratory and instrumental investigations.Results: most patients (86,2% male and 81,7% female are socially adapted. In 23,2% of patients antibodies to hepatitis C virus were first detected simultaneously with the diagnosis of cirrhosis. Medical procedures were the most common route of infection (25,6% male and 57,1% female. Genotype 1 was dominant (65.7%. Viral load over 800 000 IU/ml was detected in 36,7% of patients. ALT activity was normal or not more than 2 upper limit of normal in 59% of patients, AST – 47%. Normal levels of total bilirubin were recorded in 37% of cases.Conclusions: the first detection of antibodies to hepatitis C virus at the stage of cirrhosis, absence of jaundice, normal or low cytolytic activity once again confirms the need for screening for markers of hepatitis C virus. Dominance of genotype 1 is probably due on the one hand with features routes of transmission, and the other – with the speed of transformation chronic hepatitis to cirrhosis.

  8. Assessment of Dengue Fever Severity Through Liver Function Tests

    International Nuclear Information System (INIS)

    Ahmed, A.; Alvi, A. H.; Nawaz, A. A.; Butt, A.; Hanif, A.

    2014-01-01

    Objective: To assess the utility of liver function tests (LFTs) for early recognition and prediction of severity of Dengue fever in hospitalized patients. Study Design: An analytical study. Place and Duration of Study: Services Institute of Medical Science and Fatima Memorial Hospital, Lahore, from September - December 2010. Methodology: Admitted cases of Dengue fever were divided into 3 groups; mild, moderate and severe increases in aminotransferases. Elevation in LFTs was co-related with good or bad outcome i.e. (survival or complication free stay) or (death or complications). Results were analyzed in SPSS version 18. Results: Out of the 353 patients with mean age of 37.12 +- 15.45 years, 245 (69.4%) were males and 108 (30.6%) were females. Seventy five patients (21.2%) had mild elevation of aminotransferases (2 fold increases), 265 patients (75.1%) had moderate increases (3 to 4 fold) and 13 (3.7%) had severe (> 4 fold increase). ALT was statistically higher in patients with septicemia, hepatic and renal failure (p-value 0.05). AST was higher in almost all complications. Prolonged hospital stay was associated with raised LFTs and greater complications and mortality. AST was found to be twice as much raised as ALT. Conclusion: AST and ALT were statistically higher in patients with worse outcome thus can lead to early recognition of high risk cases. (author)

  9. Good results after laparoscopic marsupialisation of simple liver cysts

    DEFF Research Database (Denmark)

    Nørregaard, Christian Lolle; Ainsworth, Alan Patrick

    2014-01-01

    INTRODUCTION: Large simple liver cysts often tend to be symptomatic with pain being the most common symptom. MATERIAL AND METHODS: This was a retrospective study of patients who had intended laparoscopic surgery for liver cysts between December 2007 and December 2012 at a single institution...

  10. Abnormal Liver Function Tests in an Anorexia Nervosa Patient and an Atypical Manifestation of Refeeding Syndrome

    Directory of Open Access Journals (Sweden)

    Vamshidhar R. Vootla

    2015-07-01

    Full Text Available Refeeding syndrome is defined as electrolyte and fluid abnormalities that occur in significantly malnourished patients when they are refed orally, enterally, or parenterally. The principal manifestations include hypophosphatemia, hypokalemia, vitamin deficiencies, volume overload and edema. This can affect multiple organ systems, such as the cardiovascular, pulmonary, or neurological systems, secondary to the above-mentioned abnormalities. Rarely, patients may develop gastrointestinal symptoms and show abnormal liver function test results. We report the case of a 52-year-old woman with anorexia nervosa who developed refeeding syndrome and simultaneous elevations of liver function test results, which normalized upon the resolution of the refeeding syndrome.

  11. Abnormal Liver Function Tests in an Anorexia Nervosa Patient and an Atypical Manifestation of Refeeding Syndrome.

    Science.gov (United States)

    Vootla, Vamshidhar R; Daniel, Myrta

    2015-01-01

    Refeeding syndrome is defined as electrolyte and fluid abnormalities that occur in significantly malnourished patients when they are refed orally, enterally, or parenterally. The principal manifestations include hypophosphatemia, hypokalemia, vitamin deficiencies, volume overload and edema. This can affect multiple organ systems, such as the cardiovascular, pulmonary, or neurological systems, secondary to the above-mentioned abnormalities. Rarely, patients may develop gastrointestinal symptoms and show abnormal liver function test results. We report the case of a 52-year-old woman with anorexia nervosa who developed refeeding syndrome and simultaneous elevations of liver function test results, which normalized upon the resolution of the refeeding syndrome.

  12. Diagnosis of different liver fibrosis characteristics by blood tests in non-alcoholic fatty liver disease.

    Science.gov (United States)

    Calès, Paul; Boursier, Jérôme; Chaigneau, Julien; Lainé, Fabrice; Sandrini, Jeremy; Michalak, Sophie; Hubert, Isabelle; Dib, Nina; Oberti, Frédéric; Bertrais, Sandrine; Hunault, Gilles; Cavaro-Ménard, Christine; Gallois, Yves; Deugnier, Yves; Rousselet, Marie C

    2010-10-01

    Our aim was to develop an accurate, non-invasive, blood-test-based method for identifying the main characteristics of liver fibrosis in non-alcoholic fatty liver disease (NAFLD). Fibrosis was staged according to NASH-CRN and Metavir systems in 226 patients with NAFLD. A fully automated algorithm measured the fractal dimension (FD) and the area of fibrosis (AOF). Independent predictors of diagnostic targets were determined using bootstrap methods. (i) Development. Significant fibrosis defined by NASH-CRN F ≥2 was diagnosed by weight, glycaemia, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and prothrombin index [area under the receiver operating characteristic (AUROC)=0.867]; significant fibrosis defined by Metavir F ≥2 was diagnosed by weight, age, glycaemia, AST, ALT, ferritin and platelets (FibroMeter AUROC=0.941, Pfibrosis staging, Metavir staging was a better reference for blood test. Thus, the patient rate with predictive values ≥90% by tests was 97.3% with Metavir reference vs. 66.5% with NASH-CRN reference (Pfibrosis score for significant fibrosis, but not for severe fibrosis or cirrhosis, with both staging systems. Relationships between fibrosis lesions were well reflected by blood tests, e.g., the correlation between histological area and FD of fibrosis (r(s) =0.971, Pblood tests (r(s) =0.852, Pfibrosis in NAFLD can be diagnosed and quantified by blood tests with excellent accuracy. © 2010 John Wiley & Sons A/S.

  13. RSG Deployment Case Testing Results

    Energy Technology Data Exchange (ETDEWEB)

    Owsley, Stanley L.; Dodson, Michael G.; Hatchell, Brian K.; Seim, Thomas A.; Alexander, David L.; Hawthorne, Woodrow T.

    2005-09-01

    The RSG deployment case design is centered on taking the RSG system and producing a transport case that houses the RSG in a safe and controlled manner for transport. The transport case was driven by two conflicting constraints, first that the case be as light as possible, and second that it meet a stringent list of Military Specified requirements. The design team worked to extract every bit of weight from the design while striving to meet the rigorous Mil-Spec constraints. In the end compromises were made primarily on the specification side to control the overall weight of the transport case. This report outlines the case testing results.

  14. Cyclonic valve test: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Andre Sampaio; Moraes, Carlos Alberto C.; Marins, Luiz Philipe M.; Soares, Fabricio; Oliveira, Dennis; Lima, Fabio Soares de; Airao, Vinicius [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil); Ton, Tijmen [Twister BV, Rijswijk (Netherlands)

    2012-07-01

    For many years, the petroleum industry has been developing a valve that input less shear to the flow for a given required pressure drop and this can be done using the cyclonic concept. This paper presents a comparison between the performances of a cyclonic valve (low shear) and a conventional globe valve. The aim of this work is to show the advantages of using a cyclonic low shear valve instead of the commonly used in the primary separation process by PETROBRAS. Tests were performed at PETROBRAS Experimental Center (NUEX) in Aracaju/SE varying some parameters: water cut; pressure loss (from 4 kgf/cm2 to 10 kgf/cm2); flow rates (30 m3/h and 45 m3/h). Results indicates a better performance of the cyclonic valve, if compared with a conventional one, and also that the difference of the performance, is a function of several parameters (emulsion stability, water content free, and oil properties). The cyclonic valve tested can be applied as a choke valve, as a valve between separation stages (for pressure drop), or for controlling the level of vessels. We must emphasize the importance to avoid the high shear imposed by conventional valves, because once the emulsion is created, it becomes more difficult to break it. New tests are being planned to occur in 2012, but PETROBRAS is also analyzing real cases where the applications could increase the primary process efficiency. In the same way, the future installations are also being designed considering the cyclonic valve usage. (author)

  15. Impact of beta-blockers on cardiopulmonary exercise testing in patients with advanced liver disease.

    Science.gov (United States)

    Wallen, M P; Hall, A; Dias, K A; Ramos, J S; Keating, S E; Woodward, A J; Skinner, T L; Macdonald, G A; Arena, R; Coombes, J S

    2017-10-01

    Patients with advanced liver disease may develop portal hypertension that can result in variceal haemorrhage. Beta-blockers reduce portal pressure and minimise haemorrhage risk. These medications may attenuate measures of cardiopulmonary performance, such as the ventilatory threshold and peak oxygen uptake measured via cardiopulmonary exercise testing. To determine the effect of beta-blockers on cardiopulmonary exercise testing variables in patients with advanced liver disease. This was a cross-sectional analysis of 72 participants who completed a cardiopulmonary exercise test before liver transplantation. All participants remained on their usual beta-blocker dose and timing prior to the test. Variables measured during cardiopulmonary exercise testing included the ventilatory threshold, peak oxygen uptake, heart rate, oxygen pulse, the oxygen uptake efficiency slope and the ventilatory equivalents for carbon dioxide slope. Participants taking beta-blockers (n = 28) had a lower ventilatory threshold (P advanced liver disease taking beta-blockers compared to those not taking the medication. This may incorrectly risk stratify patients on beta-blockers and has implications for patient management before and after liver transplantation. The oxygen uptake efficiency slope was not influenced by beta-blockers and may therefore be a better measure of cardiopulmonary performance in this patient population. © 2017 John Wiley & Sons Ltd.

  16. Adult Liver Cancer Symptoms, Tests, Prognosis, and Stages (PDQ®)—Patient Version

    Science.gov (United States)

    Hepatocellular carcinoma is the most common type of adult primary liver cancer. The Barcelona Clinical Liver Cancer (BCLC) Staging System is used to stage liver cancer. Learn more about risk factors, signs and symptoms, tests to diagnose, prognosis, and stages of adult primary liver cancer.

  17. Radiofrequency Ablation (RFA): Development of a Flow Model for Bovine Livers for Extensive Bench Testing

    International Nuclear Information System (INIS)

    Lubienski, Andreas; Bitsch, Rudi G.; Lubienski, Katrin; Kauffmann, Guenter; Duex, Markus

    2006-01-01

    Purpose. To develop a flow model for bovine livers for extensive bench testing of technical improvements or procedure-related developments of radiofrequency ablation excluding animal experiments. Methods. The perfusion of bovine livers directly from the slaughterhouse was simulated in a liver perfusion tank developed for the experimental work. The liver perfusion medium used was a Tyrode solution prepared in accordance with physiologic criteria (as for liver transplants) which was oxygenated by an oxygenator and heated to 36.5 deg. C. Portal vein circulation was regulated via a flow- and pressure-controlled pump and arterial circulation using a dialysis machine. Flow rate and pressure were adjusted as for the physiology of a human liver converted to bovine liver conditions. The fluid discharged from the liver was returned into the perfusion system through the vena cava. Extendable precision swivel arms with the radiofrequency probe attached were mounted on the liver perfusion tank. RFA was conducted with the RF3000 generator and a 2 cm LeVeen needle (Boston Scientific, Ratingen, Germany) in a three-dimensional grid for precise localization of the generated thermolesions. Results. Four bovine livers weighing 8.4 ± 0.4 kg each were prepared, connected to the perfusion system, and consecutively perfused for the experiments. Mean arterial flow was 569 ± 43 ml/min, arterial pressure 120 mmHg, portovenous flow 1440 ± 305 ml/min, and portal pressure 10 mmHg. Macroscopic evaluation after the experiments revealed no thrombi within the hepatic vessels. A total of 136 RF thermolesions were generated with an average number of 34 per liver. Mean RF duration was 2:59 ± 2:01 min:sec with an average baseline impedance of 28.2 ± 3.4 ohms. The mean diameter of the thermolesions along the puncture channel was 22.98 ± 4.34 mm and perpendicular to the channel was 23.27 ± 4.82 mm. Conclusion. Extracorporeal perfusion of bovine livers with consecutive standardized RF ablation was

  18. Imaging-based liver function tests. Past, present and future; Bildgestuetzte Leberfunktionstests. Stand der Technik und zukuenftige Entwicklungen

    Energy Technology Data Exchange (ETDEWEB)

    Geisel, D.; Hamm, B.; Denecke, T. [Charite, Campus Virchow-Klinikum, Berlin (Germany). Dept. of Diagnostic and Interventional Radiology; Luedemann, L. [Essen University Hospital (Germany). Dept. of Medical Physics

    2015-10-15

    question to be answered is how the results may be affected by renal function and the presence of hyperbilirubinemia. As more results from clinical evaluation including comparison with postoperative liver function data become available, image-based liver function tests, especially with use of Gd-EOB as the contrast medium, have the potential to add another dimension to preoperative imaging.

  19. Test Results for CSTR Test 4

    International Nuclear Information System (INIS)

    Lee, D.D.

    2001-01-01

    One of the 3 technologies currently being developed for the Savannah River Salt Waste Processing Program is the Small-Tank Tetraphenylborate Process (STTP). This process uses sodium tetraphenylborate to precipitate and remove radioactive Cs from the waste and monosodium titanate to sorb and remove radioactive Sr and actinides. ORNL is demonstrating this process at the 1:4000 scale using a 20-liter continuous-flow stirred tank reactor (CSTR) system. The primary goal of Test 4 was to verify that the STTP process could achieve and maintain the necessary Cs decontamination while TPB was actively decomposing. Even with TPB being decomposed by the off-normal conditions of this test, the decontaimination factor for 137 Cs obtained for the filtrate from the Slurry Concentrating Tank ranged from 47,000 to 646,000, exceeding the WAC standard

  20. Muscular exercise can cause highly pathological liver function tests in healthy men.

    Science.gov (United States)

    Pettersson, Jonas; Hindorf, Ulf; Persson, Paula; Bengtsson, Thomas; Malmqvist, Ulf; Werkström, Viktoria; Ekelund, Mats

    2008-02-01

    The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals. Physical exercise can result in transient elevations of liver function tests. There is no consensus in the literature on which forms of exercise may cause changes in liver function tests and to what extent. Weightlifting results in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting. Liver function tests are significantly increased for at least 7 days after weightlifting. It is important to impose relevant restrictions on heavy muscular exercise prior to and during clinical studies. To investigate the effect of intensive muscular exercise (weightlifting) on clinical chemistry parameters reflecting liver function in healthy men. Fifteen healthy men, used to moderate physical activity not including weightlifting, performed an 1 h long weightlifting programme. Blood was sampled for clinical chemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), gamma-glutamyl transferase (gamma GT), alkaline phosphatase (ALP), bilirubin, creatine kinase (CK) and myoglobin] at repeated intervals during 7 days postexercise and at a follow-up examination 10-12 days postexercise. Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK and myoglobin) increased significantly after exercise (P exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice.

  1. FIRST RESULTS FROM OEDOTENSIOMETRIC TESTS

    Directory of Open Access Journals (Sweden)

    Luigi Cavazza

    2008-09-01

    Full Text Available An oedotensiometer was used to examine to examine the behaviour of sieved sample of a swelling soil (a vertisol as well as of the same soils treated with solution of Na+ + Ca2+ to simulate the soil changes from excessive irrigation with brackish water. The oedometer test consisted in an infiltration of water from below through a ceramic porous plate at a feeding pressure of +10 cm water and successive drainage under a depression mostly of -112 cm of water. The rate of water entry as well as the swelling rate of the sample were monitored. Preliminary considerations regards the domains in which the shrinkage curve of a swelling soil is subdivided and make hypothesis on the swelling process expected when the infiltration from below of the sample is applied. The results support the hypothesis that when the water pressure is applied some water enters rather rapidly in the larger structural pores and is followed later by the swelling in the smaller pores, responsible for the basic domain. This first conclusion demonstrates that the assumption of a simultaneous movement of solid and liquid components in the sample, which is the base of most theoretical developments for swelling soils, cannot be accepted for the tested samples. Some cases with water clogging on the sample surface confirm a late final swelling of the soil and permitted to evaluate the hydraulic conductivity of the swollen soil. These manifestations are more evident in sodicated soils. The loading of the sample reduces the swelling of the sample and seems to reduce its permeability. The reduction of the feeding water pressure further reduces the sample swelling. The draining process from saturated soil sample shows that most of the process occurs in the large pores of the structural domain. This gives the possibility to evaluate the water diffusivity coefficient for the structural domain of the sample. In draining the soil with the highest sodication there was a variation of soil volume

  2. Liver Transplant

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  3. Irradiation effects test series test IE-1 test results report

    International Nuclear Information System (INIS)

    Quapp, W.J.; Allison, C.M.; Farrar, L.C.; Mehner, A.S.

    1977-03-01

    The report describes the results of the first programmatic test in the Nuclear Regulatory Commission Irradiation Effects Test Series. This test (IE-1) used four 0.97m long PWR-type fuel rods fabricated from previously irradiated Saxton fuel. The objectives of this test were to evaluate the effect of fuel pellet density on pellet-cladding interaction during a power ramp and to evaluate the influence of the irradiated state of the fuel and cladding on rod behavior during film boiling operation. Data are presented on the behavior of irradiated fuel rods during steady-state operation, a power ramp, and film boiling operation. The effects of as-fabricated gap size, as-fabricated fuel density, rod power, and power ramp rate on pellet-cladding interaction are discussed. Test data are compared with FRAP-T2 computer model predictions, and comments on the consequences of sustained film boiling operation on irradiated fuel rod behavior are provided

  4. Irradiation effects test Series Scoping Test 1: test results report

    International Nuclear Information System (INIS)

    Quapp, W.J.; Allison, C.M.; Farrar, L.C.

    1977-09-01

    The report describes the results of the first scoping test in the Irradiation Effects Test Series conducted by the Thermal Fuels Behavior Program, which is part of the Water Reactor Research Program of EG and G Idaho, Inc. The research is sponsored by the United States Nuclear Regulatory Commission. This test used an unirradiated, three-foot-long, PWR-type fuel rod. The objective of this test was to thoroughly evaluate the remote fabrication procedures to be used for irradiated rods in future tests, handling plans, and reactor operations. Additionally, selected fuel behavior data were obtained. The fuel rod was subjected to a series of preconditioning power cycles followed by a power increase which brought the fuel rod power to about 20.4 kW/ft peak linear heat rating at a coolant mass flux of 1.83 x 10 6 lb/hr-ft 2 . Film boiling occurred for a period of 4.8 minutes following flow reductions to 9.6 x 10 5 and 7.5 x 10 5 lb/hr-ft 2 . The test fuel rod failed following reactor shutdown as a result of heavy internal and external cladding oxidation and embrittlement which occurred during the film boiling operation

  5. Chemical compatibility screening test results

    International Nuclear Information System (INIS)

    Nigrey, P.J.; Dickens, T.G.

    1997-12-01

    A program for evaluating packaging components that may be used in transporting mixed-waste forms has been developed and the first phase has been completed. This effort involved the screening of ten plastic materials in four simulant mixed-waste types. These plastics were butadiene-acrylonitrile copolymer rubber, cross-linked polyethylene (XLPE), epichlorohydrin rubber, ethylene-propylene rubber (EPDM), fluorocarbon (Viton or Kel-F), polytetrafluoroethylene, high-density polyethylene (HDPE), isobutylene-isoprene copolymer rubber (butyl), polypropylene, and styrene-butadiene rubber (SBR). The selected simulant mixed wastes were (1) an aqueous alkaline mixture of sodium nitrate and sodium nitrite; (2) a chlorinated hydrocarbon mixture; (3) a simulant liquid scintillation fluid; and (4) a mixture of ketones. The testing protocol involved exposing the respective materials to 286,000 rads of gamma radiation followed by 14-day exposures to the waste types at 60 degrees C. The seal materials were tested using vapor transport rate (VTR) measurements while the liner materials were tested using specific gravity as a metric. For these tests, a screening criterion of 0.9 g/hr/m 2 for VTR and a specific gravity change of 10% was used. Based on this work, it was concluded that while all seal materials passed exposure to the aqueous simulant mixed waste, EPDM and SBR had the lowest VTRs. In the chlorinated hydrocarbon simulant mixed waste, only Viton passed the screening tests. In both the simulant scintillation fluid mixed waste and the ketone mixture simulant mixed waste, none of the seal materials met the screening criteria. For specific gravity testing of liner materials, the data showed that while all materials with the exception of polypropylene passed the screening criteria, Kel-F, HDPE, and XLPE offered the greatest resistance to the combination of radiation and chemicals

  6. Evaluation of liver function tests in scleroderma patients.

    Science.gov (United States)

    Salem, Gehan Ibrahim Abdelrazek; Abdulrahman, Awni Ali

    2012-08-01

    Systemic sclerosis is a clinically heterogeneous, systemic disorder which affects the connective tissue of the skin, internal organs, and the walls of blood vessels. It is characterized by alterations of the microvasculature, disturbances of the immune system and by massive deposition of collagen and other matrix substances in the connective tissue. This study was done to evaluate the frequency of liver disease in patients with scleroderma and, secondarily, to study the frequency of infection of hepatitis B and C virus in these patients and determine frequency of serum auto-antibodies in this disease. We studied patients with scleroderma, localized or systemic, in the outpatient clinic of rheumatology and dermatology departments, at King Khalid University Hospital. As for a comparison, healthy persons coming to the clinic with the same mean age were considered as control group. Forty patients with the diagnosis of scleroderma included in this work, 35% had elevated gamma-glutamyl-transferase (γ-GT), 30% had elevated alkaline phosphatase (AP) and in 17.5%, the alanine-amino-transferase (ALT) was above the reference values. The ALT had changed to be more in scleroderma patients than in controls. Twenty percent (20%) of the patients tested positive for anti-smooth muscle antibodies (anti-SMA) and only one patient had anti-mitochondrial antibodies (AMA). There was no statistical difference between the two groups regarding antibody testing. Anti-HCV antibodies were observed in one patient, and HBsAg was detected in another scleroderma patient. There was no patient with clinically significant hepatic disease. In this study, although changes in liver enzymes in patients with scleroderma were not uncommon, there was no scleroderma patient with clinical manifestations of liver disease.

  7. Irradiation effects test series, test IE-5. Test results report

    International Nuclear Information System (INIS)

    Croucher, D.W.; Yackle, T.R.; Allison, C.M.; Ploger, S.A.

    1978-01-01

    Test IE-5, conducted in the Power Burst Facility at the Idaho National Engineering Laboratory, employed three 0.97-m long pressurized water reactor type fuel rods, fabricated from previously irradiated zircaloy-4 cladding and one similar rod fabricated from unirradiated cladding. The objectives of the test were to evaluate the influence of simulated fission products, cladding irradiation damage, and fuel rod internal pressure on pellet-cladding interaction during a power ramp and on fuel rod behavior during film boiling operation. The four rods were subjected to a preconditioning period, a power ramp to an average fuel rod peak power of 65 kW/m, and steady state operation for one hour at a coolant mass flux of 4880 kg/s-m 2 for each rod. After a flow reduction to 1800 kg/s-m 2 , film boiling occurred on one rod. Additional flow reductions to 970 kg/s-m 2 produced film boiling on the three remaining fuel rods. Maximum time in film boiling was 80s. The rod having the highest initial internal pressure (8.3 MPa) failed 10s after the onset of film boiling. A second rod failed about 90s after reactor shutdown. The report contains a description of the experiment, the test conduct, test results, and results from the preliminary postirradiation examination. Calculations using a transient fuel rod behavior code are compared with the test results

  8. LONG-TERM RESULTS AFTER LIVER-TRANSPLANTATION IN ADULTS

    NARCIS (Netherlands)

    HAAGSMA, EB; KLOMPMAKER, IJ; SLOOFF, MJH

    1991-01-01

    The prospects for patients who survive the first year after liver transplantation are discussed. The 10-year survival for these patients is more than 80%. The quality of life is good, as measured on self-assessment scales. Pregnancy is possible. The main side-effects of drugs concern osteoporosis

  9. Liver histology and follow up of 68 patients with ulcerative colitis and normal liver function tests.

    OpenAIRE

    Broomé, U; Glaumann, H; Hultcrantz, R

    1990-01-01

    Hepatobiliary disorders are well known complications in patients with ulcerative colitis but it is not possible to predict those patients with ulcerative colitis who will eventually develop liver disease. In this study, liver biopsies from 74 patients with ulcerative colitis have been reevaluated. None of the patients showed clinical or biochemical signs of liver disease at the time of biopsy. Thirty seven (50%) had a completely normal liver biopsy. The others showed minimal portal inflammati...

  10. Railgun bore material test results

    International Nuclear Information System (INIS)

    Wang, S.Y.; Burton, R.L.; Witherspoon, F.D.; Bloomberg, H.W.; Goldstein, S.A.; Tidman, D.A.; Winsor, N.K.

    1987-01-01

    GT-Devices, Inc. has constructed a material test facility (MTF) to study the fundamental heat transfer problem of both railgun and electrothermal guns, and to test candidate gun materials under real plasma conditions. The MTF electrothermally produces gigawatt-level plasmas with pulse lengths of 10-30 microseconds. Circular bore and non-circular bore test barrels have been successfully operated under a wide range of simulated heating environments for EM launchers. Diagnostics include piezoelectric MHz pressure probes, time-of-flight probes, and current and voltage probes. Ablation measurements are accomplished by weighing and optical inspection, including borescope, optical microscope, and scanning electron microscope (SEM). From these measurements the ablation threshold for both the rail and insulator materials can be determined as a function of plasma heating. The MTF diagnostics are supported by an unsteady 1-D model of MTF which uses the flux-corrected transport (FCT) algorithm to calculate the fluid equations in conservative form. A major advantage of the FCT algorithm is that it can model gas dynamic shock behaviour without the requirement of numerical diffusion. The principle use of the code is to predict the material surface temperature ΔT/α from the unsteady heat transfer q(t)

  11. Boraflex test results and evaluation

    International Nuclear Information System (INIS)

    Lindquist, K.; Kline, D.E.; Haley, T.C.

    1993-02-01

    New data developed, collected, and evaluated to further assess the in-pool performance of the neutron absorber material, Boraflex. The data are from new EPRI test programs, utility surveillance programs, and blackness testing at a number of plants. This new data provides a basis for quantifying the gap phenomenon in full length panels of Boraflex in spent fuel racks; the maximum anticipated gap size, frequency of gap occurrence, and axial distribution of gaps. Methods have been developed to assess the reactivity effects of gaps and Boraflex shrinkage. The analyses presented demonstrates that the reactivity effect of gaps is very small, not much larger than the statistical variations inherent in the calculational method. The data and analyses presented serve to close the issue of gap formation and shrinkage in panels of Boraflex and the effect of such gaps and shrinkage on the reactivity of the fuel/rack configuration. Ongoing EPRI programs to assess the long term performance of Boraflex in spent fuel storage racks are described

  12. Irradiation Effects Test Series: Test IE-3. Test results report

    International Nuclear Information System (INIS)

    Farrar, L.C.; Allison, C.M.; Croucher, D.W.; Ploger, S.A.

    1977-10-01

    The objectives of the test reported were to: (a) determine the behavior of irradiated fuel rods subjected to a rapid power increase during which the possibility of a pellet-cladding mechanical interaction failure is enhanced and (b) determine the behavior of these fuel rods during film boiling following this rapid power increase. Test IE-3 used four 0.97-m long pressurized water reactor type fuel rods fabricated from previously irradiated fuel. The fuel rods were subjected to a preconditioning period, followed by a power ramp to 69 kW/m at a coolant mass flux of 4920 kg/s-m 2 . After a flow reduction to 2120 kg/s-m 2 , film boiling occurred on the fuel rods. One rod failed approximately 45 seconds after the reactor was shut down as a result of cladding embrittlement due to extensive cladding oxidation. Data are presented on the behavior of these irradiated fuel rods during steady-state operation, the power ramp, and film boiling operation. The effects of a power ramp and power ramp rates on pellet-cladding interaction are discussed. Test data are compared with FRAP-T3 computer model calculations and data from a previous Irradiation Effects test in which four irradiated fuel rods of a similar design were tested. Test IE-3 results indicate that the irradiated state of the fuel rods did not significantly affect fuel rod behavior during normal, abnormal (power ramp of 20 kW/m per minute), and accident (film boiling) conditions

  13. Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis

    NARCIS (Netherlands)

    Westra, Inge M.; Mutsaers, Henricus A. M.; Luangmonkong, Theerut; Hadi, Mackenzie; Oosterhuis, Dorenda; de Jong, Koert P.; Groothuis, Geny M. M.; Olinga, Peter

    Liver fibrosis is the progressive accumulation of connective tissue ultimately resulting in loss of organ function. Currently, no effective antifibrotics are available due to a lack of reliable human models. Here we investigated the fibrotic process in human precision-cut liver slices (PCLS) and

  14. /sup 131/I-BSP liver function test by BSP tolerance

    Energy Technology Data Exchange (ETDEWEB)

    Kanda, K [Minami Osaka Hospital (Japan)

    1974-11-01

    /sup 131/I-BSP liver function test after BSP intravenous tolerance was discussed, assuming that the reason why measurements of /sup 131/I-BSP retention rate at 30 minutes and /sup 131/I-BSP disappearance rate in blood showed respectable overlapping between normal group and group with slight liver disorders as compared with BSP test and the reason why differential diagnosis was difficult were due to underestimate of tolerance volume of /sup 131/I-BSP. /sup 131/I-BSP was observed with time as to 70 persons with normal liver function and 257 cases of liver diseases, using 5, 3 and 2 mg of non-radioactive BSP tolerance volume per kilogram of body weight. /sup 131/I-BSP retention rate at 30 minutes and /sup 131/I-BSP disappearance rate in blood are possible to separate overlapping over control in each measurement value at 3 to 5 mg/kg of tolerance, and in comparison of 3 mg and 5 mg, the latter showed a little excellent result. So, it was decided that tolerance of 3 mg/kg was a proper dose, considering tolerance to liver cells. /sup 131/I-BSP retention rate at 30 minutes was a little excellent in accuracy and disappearance rate in blood after BSP tolerance is simple and profitable for practical use because collection of blood was only one time and measurement could be made with whole blood. As mentioned above, this method is seemed to be useful to practice of liver function test.

  15. Irradiation Effects Test Series: Test IE-2. Test results report

    International Nuclear Information System (INIS)

    Allison, C.M.; Croucher, D.W.; Ploger, S.A.; Mehner, A.S.

    1977-08-01

    The report describes the results of a test using four 0.97-m long PWR-type fuel rods with differences in diametral gap and cladding irradiation. The objective of this test was to provide information about the effects of these differences on fuel rod behavior during quasi-equilibrium and film boiling operation. The fuel rods were subjected to a series of preconditioning power cycles of less than 30 kW/m. Rod powers were then increased to 68 kW/m at a coolant mass flux of 4900 kg/s-m 2 . After one hour at 68 kW/m, a power-cooling-mismatch sequence was initiated by a flow reduction at constant power. At a flow of 2550 kg/s-m 2 , the onset of film boiling occurred on one rod, Rod IE-011. An additional flow reduction to 2245 kg/s-m 2 caused the onset of film boiling on the remaining three rods. Data are presented on the behavior of fuel rods during quasiequilibrium and during film boiling operation. The effects of initial gap size, cladding irradiation, rod power cycling, a rapid power increase, and sustained film boiling are discussed. These discussions are based on measured test data, preliminary postirradiation examination results, and comparisons of results with FRAP-T3 computer model calculations

  16. Correlation between plasma endothelin-1 levels and severity of septic liver failure quantified by maximal liver function capacity (LiMAx test. A prospective study.

    Directory of Open Access Journals (Sweden)

    Magnus F Kaffarnik

    Full Text Available To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test and endothelin-1, TNF-α and IL-6 in septic surgical patients.28 septic patients (8 female, 20 male, age range 35-80y were prospectively investigated on a surgical intensive care unit. Liver function, defined by LiMAx test, and measurements of plasma levels of endothelin-1, TNF-α and IL-6 were carried out within the first 24 hours after onset of septic symptoms, followed by day 2, 5 and 10. Patients were divided into 2 groups (group A: LiMAx ≥100 μg/kg/h, moderate liver dysfunction; group B: LiMAx <100 μg/kg/h, severe liver dysfunction for analysis and investigated regarding the correlation between endothelin-1 and the severity of liver failure, quantified by LiMAx test.Group B showed significant higher results for endothelin-1 than patients in group A (P = 0.01, d5; 0.02, d10. For TNF-α, group B revealed higher results than group A, with a significant difference on day 10 (P = 0.005. IL-6 showed a non-significant trend to higher results in group B. The Spearman's rank correlation coefficient revealed a significant correlation between LiMAx and endothelin-1 (-0.434; P <0.001, TNF-α (-0.515; P <0.001 and IL-6 (-0.590; P <0.001.Sepsis-related hepatic dysfunction is associated with elevated plasma levels of endothelin-1, TNF-α and IL-6. Low LiMAx results combined with increased endothelin-1 and TNF-α and a favourable correlation between LiMAx and cytokine values support the findings of a crucial role of Endothelin-1 and TNF-α in development of septic liver failure.

  17. Salt decontamination demonstration test results

    International Nuclear Information System (INIS)

    Snell, E.B.; Heng, C.J.

    1983-06-01

    The Salt Decontamination Demonstration confirmed that the precipitation process could be used for large-scale decontamination of radioactive waste sale solution. Although a number of refinements are necessary to safely process the long-term requirement of 5 million gallons of waste salt solution per year, there were no observations to suggest that any fundamentals of the process require re-evaluation. Major accomplishments were: (1) 518,000 gallons of decontaminated filtrate were produced from 427,000 gallons of waste salt solution from tank 24H. The demonstration goal was to produce a minimum of 200,000 gallons of decontaminated salt solution; (2) cesium activity in the filtrate was reduced by a factor of 43,000 below the cesium activity in the tank 24 solution. This decontamination factor (DF) exceeded the demonstration goal of a DF greater than 10,000; (3) average strontium-90 activity in the filtrate was reduced by a factor of 26 to less than 10 3 d/m/ml versus a goal of less than 10 4 d/m/ml; and (4) the concentrated precipitate was washed to a final sodium ion concentration of 0.15 M, well below the 0.225 M upper limit for DWPF feed. These accomplishments were achieved on schedule and without incident. Total radiation exposure to personnel was less than 350 mrem and resulted primarily from sampling precipitate slurry inside tank 48. 3 references, 6 figures, 2 tables

  18. A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane, 2

    International Nuclear Information System (INIS)

    Kawa, Soukichi; Hazama, Hiroshi; Kojima, Michimasa

    1986-01-01

    We produced labeled neoglycoprotein (GHSA) that is physiologically equivalent to ASGP, and quantitatively examined whether its uptake by the liver is dose-related using the following methods: 1) binding assay between GHSA and ASGP receptors, 2) measurement of the liver extraction ratio in the initial circulation following administration into the portal vein, and 3) measurement of clearance in normal rats and rats with galacosamine-induced acute liver disorder. The binding assay showed a linear relationship between the concentration of 125 I-GHSA and the amount of ASGP receptors obtained from the rat liver. A membrane assay using 125 I-GHSA and the liver cell membrane revealed similar results. The liver extraction ratio in the initial circulation following the administration into the portal vein of normal rabbits was highly dose-dependent (r = -0.95 in the range of 5 - 100 μg GHSA). Serial imaging of 99m Tc-GHSA during two-hour period after administration into the peripheral blood showed specific accumulation in the liver beginning immediately after the intravenous injection and subsequent transport mainly via the biliary system into the small intestine in the normal rat and mainly into the urine in the bile duct ligated rat. As a dynamic model of 99m Tc-GHSA, its circulation through the heart and liver and inactivated release from the liver was used, and two-compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. The concentration of administered 99m Tc-GHSA (50 - 100 μg/100 g body weight) showed a positive linear relationship with clearance. Administration of 50 μg/100 g body weight of 99m Tc-GHSA revealed a significant correlation (p < 0.001) between clearance and ASGP receptor activity in normal rats and rats with galactosamine-induced acute liver disorder. (J.P.N.)

  19. Perfusion maps of the whole liver based on high temporal and spatial resolution contrast-enhanced MRI (4D THRIVE): Feasibility and initial results in focal liver lesions

    International Nuclear Information System (INIS)

    Coenegrachts, Kenneth; Ghekiere, Johan; Denolin, Vincent; Gabriele, Beck; Herigault, Gwen; Haspeslagh, Marc; Daled, Peter; Bipat, Shandra; Stoker, Jaap; Rigauts, Hans

    2010-01-01

    Purpose: To prospectively evaluate a new imaging sequence (4D THRIVE) for whole liver perfusion in high temporal and spatial resolution. Feasibility of parametric mapping and its potential for characterizing focal liver lesions (FLLs) are investigated. Materials and methods: Fifteen patients suspected for colorectal liver metastases (LMs) were included. Parametric maps were evaluated qualitatively (ring-enhancement and lesion heterogeneity) and compared to three-phased contrast-enhanced MRI. Quantitative analysis was based on average perfusion values of entire FLLs. Reference standard comprised surgery with histopathology or follow-up imaging. Fisher's exact test was used for qualitative and Kruskal-Wallis test for quantitative analysis. Results: In total 29 LMs, 17 hemangiomas and 4 focal nodular hyperplasias were evaluated. FLLs could be differentiated by qualitative assessment of parametric maps respectively three-phased contrast-enhanced MRI (Fisher's p < 0.001 for comparisons between LMs and hemangiomas and LMs and FNHs for both ring-enhancement and lesion heterogeneity) rather than by quantitative analysis of parametric maps (Chi-square for Kep = 0.33 (p = 0.847) and Chi-square for Kel = 1.35 (p = 0.509)). Conclusion: This preliminary study shows potential of 4D THRIVE for whole liver imaging enabling calculation of parametric maps. Qualitative rather than quantitative analysis was accurate for differentiating malignant and benign FLLs.

  20. Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies

    Directory of Open Access Journals (Sweden)

    Gregory H. Underhill

    2018-01-01

    Full Text Available In vitro models of the human liver are important for the following: (1 mitigating the risk of drug-induced liver injury to human beings, (2 modeling human liver diseases, (3 elucidating the role of single and combinatorial microenvironmental cues on liver cell function, and (4 enabling cell-based therapies in the clinic. Methods to isolate and culture primary human hepatocytes (PHHs, the gold standard for building human liver models, were developed several decades ago; however, PHHs show a precipitous decline in phenotypic functions in 2-dimensional extracellular matrix–coated conventional culture formats, which does not allow chronic treatment with drugs and other stimuli. The development of several engineering tools, such as cellular microarrays, protein micropatterning, microfluidics, biomaterial scaffolds, and bioprinting, now allow precise control over the cellular microenvironment for enhancing the function of both PHHs and induced pluripotent stem cell–derived human hepatocyte-like cells; long-term (4+ weeks stabilization of hepatocellular function typically requires co-cultivation with liver-derived or non–liver-derived nonparenchymal cell types. In addition, the recent development of liver organoid culture systems can provide a strategy for the enhanced expansion of therapeutically relevant cell types. Here, we discuss advances in engineering approaches for constructing in vitro human liver models that have utility in drug screening and for determining microenvironmental determinants of liver cell differentiation/function. Design features and validation data of representative models are presented to highlight major trends followed by the discussion of pending issues that need to be addressed. Overall, bioengineered liver models have significantly advanced our understanding of liver function and injury, which will prove useful for drug development and ultimately cell-based therapies.

  1. Biochemical liver function test parameter levels in relation to treatment response in liver metastatic colorectal patients treated with FOLFOX4 with or without bevacizumab

    Directory of Open Access Journals (Sweden)

    Denić Kristina

    2016-01-01

    Full Text Available Introduction. Combined use of bevacizumab and conventional anticancer drugs leads to a significant improvement of treatment response in patients with metastatic colorectal carcinoma (CRC. Conventional treatment protocols exert undesired effects on the liver tissue. Hepatotoxic effects are manifested as a disturbance of liver function test parameters. The relation between clinical outcome and disorder of biochemical parameters has not been completely evaluated. Objective. The objective of our study was to examine whether clinical outcome in patients with liver metastatic CRC correlates with the level of liver function test parameters. Methods. The study included 96 patients with untreated liver metastatic CRC who received FOLFOX4 protocol with or without bevacizumab. Biochemical liver parameters were performed before and after the treatment completion. Treatment response was evaluated as disease regression, stable disease, and disease progression. The patients were divided into three groups according to the accomplished treatment response. Results. In the group of patients with disease regression the post-treatment levels of aspartate aminotransferase, alanine aminotransferase, and bilirubin were statistically significantly increased. In contrast to this, gamma-glutamyltransferase and protein post-treatment values were significantly lower in relation to initial values. In patients with stable disease, difference was found only in the level of proteins being lower after the treatment. In patients with disease progression, values of aspartate aminotransferase and bilirubin were significantly increased after completed treatment. Conclusion. Treatment responses are not completely associated with the level of liver function test parameters. The only parameter which correlated with treatment response is gamma-glutamyltransferase. Its decrease is accompanied with disease regression.

  2. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.

    Science.gov (United States)

    Boursier, Jérôme; Vergniol, Julien; Guillet, Anne; Hiriart, Jean-Baptiste; Lannes, Adrien; Le Bail, Brigitte; Michalak, Sophie; Chermak, Faiza; Bertrais, Sandrine; Foucher, Juliette; Oberti, Frédéric; Charbonnier, Maude; Fouchard-Hubert, Isabelle; Rousselet, Marie-Christine; Calès, Paul; de Lédinghen, Victor

    2016-09-01

    NAFLD is highly prevalent but only a small subset of patients develop advanced liver fibrosis with impaired liver-related prognosis. We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM) by FibroScan for the diagnosis of liver fibrosis and the evaluation of prognosis in NAFLD. Diagnostic accuracy was evaluated in a cross-sectional study including 452 NAFLD patients with liver biopsy (NASH-CRN fibrosis stage), LSM, and eight blood fibrosis tests (BARD, NAFLD fibrosis score, FibroMeter(NAFLD), aspartate aminotransferase to platelet ratio index (APRI), FIB4, FibroTest, Hepascore, FibroMeter(V2G)). Prognostic accuracy was evaluated in a longitudinal study including 360 NAFLD patients. LSM and FibroMeter(V2G) were the two best-performing tests in the cross-sectional study: AUROCs for advanced fibrosis (F3/4) were, respectively, 0.831±0.019 and 0.817±0.020 (p⩽0.041 vs. other tests); rates of patients with ⩾90% negative/positive predictive values for F3/4 were 56.4% and 46.7% (ptests); Obuchowski indexes were 0.834±0.014 and 0.798±0.016 (p⩽0.036 vs. other tests). Two fibrosis classifications were developed to precisely estimate the histological fibrosis stage from LSM or FibroMeter(V2G) results without liver biopsy (diagnostic accuracy, respectively: 80.8% vs. 77.4%, p=0.190). Kaplan-Meier curves in the longitudinal study showed that both classifications categorised NAFLD patients into subgroups with significantly different prognoses (pfibrosis classification, the worse was the prognosis. LSM and FibroMeter(V2G) were the most accurate of nine evaluated tests for the non-invasive diagnosis of liver fibrosis in NAFLD. LSM and FibroMeter(V2G) fibrosis classifications help physicians estimate both fibrosis stage and patient prognosis in clinical practice. The amount of liver fibrosis is the main determinant of the liver-related prognosis in patients with non-alcoholic fatty liver disease (NAFLD). We evaluated eight blood tests and Fibro

  3. Abnormal Cervical Cancer Screening Test Results

    Science.gov (United States)

    ... AQ FREQUENTLY ASKED QUESTIONS FAQ187 GYNECOLOGIC PROBLEMS Abnormal Cervical Cancer Screening Test Results • What is cervical cancer screening? • What causes abnormal cervical cancer screening test ...

  4. A study on relationship between liver scintigram and various kinds of liver function tests

    International Nuclear Information System (INIS)

    Watanabe, Kazuo

    1975-01-01

    The relationship between GOT, γ-globulin, alkaline phosphatase, ICG-R 15 and liver scintigram (anterior view) was studied in 37 patients with miscellaneous liver diseases. The length of the splenic image and the difference between right side and left side widths of the liver were indicated as liver scintigraphic findings. 1. γ-globulin and alkaline phosphatase tended to be slightly higher with remarkable splenic image. 2. All three patients with over 35% of ICG-R 15 had atrophic type of the right lobe showing more than 13 cm of the spleen. At first sight, they were diagnosed as having liver cirrhosis. On the other hand, some of the patients who had normal or slightly abnormal ICG-R 15 were suspected of having liver cirrhosis because of the long splenic image, but all had remarkable swelling of the right lobe. 3. The patients whom the difference between the right side and the left side widths was below 3 cm contained many patients with liver cirrhosis acompanied by atrophic type of the right lobe and remarkably abnormal ICG-R 15 . (Namekawa, K.)

  5. Evaluation of liver function tests of HIV positive patients on ...

    African Journals Online (AJOL)

    Liver enzymes-alanine and aspartate aminotransferases and alkaline phosphatase (AST, ALT and ALP), bilirubin and serum proteins were determined using standard laboratory methods and these parameters were used to evaluate the liver function of human immunodeficiency virus (HIV)- positive patients receiving ...

  6. Assessment of biochemical liver function tests in relation to age ...

    African Journals Online (AJOL)

    Background and Objective: Multiorgan failure including liver dysfunction is a common finding in sickle cell anemia (SCA) patients, the cause of which is multifactorial with advancing age said to be a major determinant. There is a paucity of data on liver function among SCA patients in relation to age in northern Nigerian ...

  7. Accelerated hyperfractionated hepatic irradiation in the management of patients with liver metastases: Results of the RTOG dose escalating protocol

    International Nuclear Information System (INIS)

    Russell, A.H.; Clyde, C.; Wasserman, T.H.; Turner, S.S.; Rotman, M.

    1993-01-01

    This study was prepared to address two objectives: (a) to determine whether progressively higher total doses of hepatic irradiation can prolong survival in a selected population of patients with liver metastases and (b) to refine existing concepts of liver tolerance for fractionated external radiation. One hundred seventy-three analyzable patients with computed tomography measurable liver metastases from primary cancers of the gastrointestinal tract were entered on a dose escalating protocol of twice daily hepatic irradiation employing fractions of 1.5 Gy separated by 4 hr or longer. Sequential groups of patients received 27 Gy, 30 Gy, and 33 Gy to the entire liver and were monitored for acute and late toxicities, survival, and cause of death. Dose escalation was implemented following survival of 10 patients at each dose level for a period of 6 months or longer without clinical or biochemical evidence of radiation hepatitis. The use of progressively larger total doses of radiation did not prolong median survival or decrease the frequency with which liver metastases were the cause of death. None of 122 patients entered at the 27 Gy and 30 Gy dose levels revealed clinical or biochemical evidence of radiation induced liver injury. Five of 51 patients entered at the 33 Gy level revealed clinical or biochemical evidence of late liver injury with an actuarial risk of severe (Grade 3) radiation hepatitis of 10.0% at 6 months, resulting in closure of the study to patient entry. The study design could not credibly establish a safe dose for hepatic irradiation, however, it did succeed in determining that 33 Gy in fractions of 1.5 Gy is unsafe, carrying a substantial risk of delayed radiation injury. The absence of apparent late liver injury at the 27 Gy and 30 Gy dose levels suggests that a prior clinical trial of adjuvant hepatic irradiation in patients with resected colon cancer may have employed an insufficient radiation dose (21 Gy) to fully test the question

  8. Liver

    International Nuclear Information System (INIS)

    Bernardino, M.E.; Sones, P.J. Jr.; Barton Price, R.; Berkman, W.A.

    1984-01-01

    Evaluation of the liver for focal lesions is extremely important because the liver is one of the most common sites for metastatic disease. Most patients with metastatic deposits to the liver have a survival rate of about 6 months. Thus, metastatic disease to the liver has an extremely grave prognosis. In the past patients with hepatic lesions had no therapeutic recourse. However, with recent aggressive surgical advances (such as partial hepatectomies) and hepatic artery embolization, survival of patients with hepatic metastases has increased. Thus it is important for noninvasive imaging not only to detect lesions early in their course, but also to give their true hepatic involvement and the extent of the neoplastic process elsewhere in the body. Recent advances in imaging have been rapidly changing over the past 5 years. These changes have been more rapid in computed tomography (CT) and ultrasound than in radionuclide imaging. Thus, the question addressed in this chapter is: What is the relationship of hepatic ultrasound to the other current diagnostic modalities in detecting metastatic liver disease and other focal liver lesions? Also, what is its possible future relationship to nuclear magnetic resonance?

  9. Request of laboratory liver tests in primary care in Spain: potential savings if appropriateness indicator targets were achieved.

    Science.gov (United States)

    Salinas, Maria; López-Garrigós, Maite; Flores, Emilio; Uris, Joaquín; Leiva-Salinas, Carlos

    2015-10-01

    Liver laboratory tests are used to screen for liver disease, suggest the underlying cause, estimate the severity, assess prognosis, and monitor the efficacy of therapy. The aim of this study was to compare the liver laboratory tests requesting patterns by GPs in Spain, according to geographic and hospital characteristics, to investigate the degree of requesting appropriateness. One hundred and forty-one clinical laboratories were invited to participate from diverse regions across Spain. They filed out the number of laboratory liver tests requested by GPs for the year 2012. Two types of appropriateness indicators were calculated: every test request per 1000 inhabitants or ratios of related tests requests. The indicator results obtained were compared between the different hospitals, according to their setting, location, and management. The savings generated, if each area would have achieved indicator targets, were calculated. We recruited 76 laboratories covering a population of 17,679,195 inhabitants. GPs requested 20,916,780 laboratory liver tests in the year 2012. No differences were obtained according to their setting. Lactate dehydrogenase and direct bilirubin per 1000 inhabitants were significantly higher in institutions with private management. Largest differences were observed between communities. Nine, 31, 0, and 13 laboratories, respectively, achieved the aspartate aminotransferase, lactate dehydrogenase, γ-glutamyl transpeptidase, and total bilirubin-related alanine aminotransferase indicator targets. Reaching ratios would have resulted in savings of €1,028,468. There was a high variability in the request of liver tests. This emphasizes the need to implement interventions to improve appropriate use of liver tests.

  10. [Research progress of Chinese herbal medicine and traditional Chinese medicine resulting in liver injury].

    Science.gov (United States)

    Wang, Jingli; Zhou, Chaofan

    2011-12-01

    The adverse reactions caused by Chinese herbal medicine and traditional Chinese medicine are reported increased in recent years, among which the acute liver injury caused by Chinese herbal medicine accounts for 21.5% of total liver injuries. Despite the misuse of traditional Chinese medicine not in accordance with differentiation of symptoms and signs, the adverse reaction of Chinese herbal medicine itself can't be little to these adverse events. The paper summarizes the most common categories of traditional Chinese medicine resulting in liver injury, the mechanism, pathological characteristics, clinical symptom of liver injury, the reasons of the reaction and how to prevent. The research aims to enhance the clinical physician recognition of liver injury caused by Chinese herbal medicine, in order to ensure the safe and rational usage of traditional Chinese medicine.

  11. Final results of a long-term, clinical follow-up in fatty liver patients

    DEFF Research Database (Denmark)

    Dam-Larsen, Sanne; Becker, Ulrik; Franzmann, Maria-Benedicte

    2009-01-01

    OBJECTIVE: There is increasing focus on non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to conduct a long-term clinical follow-up of patients with biopsy-confirmed fatty liver without inflammation or significant fibrosis (pure fatty liver), to analyse for potential risk....... All admissions, discharge diagnoses and causes of death during follow-up were collected. All surviving patients were invited to a clinical follow-up. RESULTS: The follow-up period was 20.4 and 21.0 years, respectively, for the NAFLD and alcoholic fatty liver disease (AFLD) groups. Two NAFLD patients...... of death. Patients with AFLD died primarily from cirrhosis and other alcohol-related disorders, whereas in patients with NAFLD the main causes of death were cardiovascular disease and cancer. CONCLUSIONS: For patients with pure non-alcoholic fatty liver, survival was good and independent...

  12. Liver function test with 99mTc-labelled bilirubin in children

    International Nuclear Information System (INIS)

    Teichmann, B.; Kaempfer, I.; Schneider, G.

    1989-01-01

    Because of central role of bilirubin in the metabolism of liver it is well suited for liver function tests. Different parameters of hepatocellular partial function and histological findings were studied in patients suffering from functional hyperbilirubinaemia (n = 15), liver cirrhosis (n = 7) and 6 patients recovering from acute hepatitis. After intravenous injection of 99m Tc-bilirubin blood clearance and intestinal excretion in percentages of bilirubin were determined. In patients with cirrhosis the initial phase as well as the intestinal excretion of bilirubin were delayed. This liver function test is useful in the pediatric special diagnosis for investigations during the course of the illness and for assessment of therapeutic activities. (author)

  13. Relationship between postoperative erythromycin breath test and early morbidity in liver transplant recipients

    DEFF Research Database (Denmark)

    Schmidt, Lars E; Rasmussen, Allan; Kirkegaard, Preben

    2003-01-01

    of cyclosporine and tacrolimus nephrotoxicity, episodes of early graft rejection, early graft function, and graft survival. RESULTS: Cyclosporine and tacrolimus nephrotoxicity were associated with low postoperative ERMBT values (mean 0.63%+/-0.25% 14C/hr vs. 1.35%+/-0.84% 14C/hr, P=0.02). No significant...... association between early graft rejection and ERMBT values was demonstrated. There was a significant inverse correlation between postoperative ERMBT values and the time to normalization of international normalized ratio as a measure of early graft function (r=-0.78, PGraft loss was associated......BACKGROUND: Interindividual variability in dosage requirements of the calcineurin inhibitor immunosuppressive agents cyclosporine and tacrolimus after liver transplantation may result from differences in the CYP3A activity of the liver graft. Early postoperative erythromycin breath test (ERMBT...

  14. Reproducibility of the results in ultrasonic testing

    International Nuclear Information System (INIS)

    Chalaye, M.; Launay, J.P.; Thomas, A.

    1980-12-01

    This memorandum reports on the conclusions of the tests carried out in order to evaluate the reproducibility of ultrasonic tests made on welded joints. FRAMATOME have started a study to assess the dispersion of results afforded by the test line and to characterize its behaviour. The tests covered sensors and ultrasonic generators said to be identical to each other (same commercial batch) [fr

  15. Results after surgical treatment of liver metastases in patients with high-grade gastroenteropancreatic neuroendocrine carcinomas

    DEFF Research Database (Denmark)

    Galleberg, R B; Knigge, U; Tiensuu Janson, E

    2017-01-01

    Background: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce......., particularly for the group with a Ki-67 in the relatively lower G3 range. Our findings indicate a possible role for surgical treatment of liver metastases in the management of this patient population.......Background: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce....... The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. Methods: 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended...

  16. Routine testing of liver function before and after elective laparoscopic cholecystectomy: is it necessary?

    LENUS (Irish Health Repository)

    Ahmad, Nasir Zaheer

    2012-01-31

    BACKGROUND AND OBJECTIVES: Liver function tests (LFTs) include alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bilirubin. The role of routine testing before and after laparoscopic cholecystectomy was evaluated in this study. PATIENTS AND METHODS: A total of 355 patients were retrospectively analyzed by examining the LFTs the day before, the day after, and 3 weeks after the surgery. The Wilcoxon signed-rank test and Student t test were performed to determine statistical significance. RESULTS: Alterations in the serum AST, ALT, and GGT were seen on the first postoperative day. Minor changes were seen in bilirubin and ALP. An overall disturbance in the LFTs was seen in more than two-thirds of the cases. Repeat LFTs performed after 3 weeks on follow-up were found to be within normal limits. CONCLUSION: Mild-to-moderate elevation in preoperative LFTs may not be associated with any deleterious effect, and, in the absence of clinical indications, routine preoperative or postoperative liver function testing is unnecessary.

  17. ELF-test less accurately identifies liver cirrhosis diagnosed by liver stiffness measurement in non-Asian women with chronic hepatitis B

    NARCIS (Netherlands)

    Harkisoen, S.; Boland, G. J.; van den Hoek, J. A. R.; van Erpecum, K. J.; Hoepelman, A. I. M.; Arends, J. E.

    2014-01-01

    The enhanced liver fibrosis test (ELF-test) has been validated for several hepatic diseases. However, its performance in chronic hepatitis B virus (CHB) infected patients is uncertain. This study investigates the diagnostic value of the ELF test for cirrhosis identified by liver stiffness

  18. Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.

    Science.gov (United States)

    Zarski, Jean-Pierre; Sturm, Nathalie; Guechot, Jérôme; Paris, Adeline; Zafrani, Elie-Serge; Asselah, Tarik; Boisson, Renée-Claude; Bosson, Jean-Luc; Guyader, Dominique; Renversez, Jean-Charles; Bronowicki, Jean-Pierre; Gelineau, Marie-Christine; Tran, Albert; Trocme, Candice; De Ledinghen, Victor; Lasnier, Elisabeth; Poujol-Robert, Armelle; Ziegler, Frédéric; Bourliere, Marc; Voitot, Hélène; Larrey, Dominique; Rosenthal-Allieri, Maria Alessandra; Fouchard Hubert, Isabelle; Bailly, François; Vaubourdolle, Michel

    2012-01-01

    Blood tests and transient elastography (Fibroscan™) have been developed as alternatives to liver biopsy. This ANRS HCEP-23 study compared the diagnostic accuracy of nine blood tests and transient elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients with chronic hepatitis C (CHC). This was a multicentre prospective independent study in 19 French University hospitals of consecutive adult patients having simultaneous liver biopsy, biochemical blood tests (performed in a centralized laboratory) and Fibroscan™. Two experienced pathologists independently reviewed the liver biopsies (mean length=25±8.4 mm). Performance was assessed using ROC curves corrected by Obuchowski's method. Fibroscan™ was not interpretable in 113 (22%) patients. In the 382 patients having both blood tests and interpretable Fibroscan™, Fibroscan™ performed similarly to the best blood tests for the diagnosis of significant fibrosis and cirrhosis. Obuchowski's measure showed Fibrometer® (0.86), Fibrotest® (0.84), Hepascore® (0.84), and interpretable Fibroscan™ (0.84) to be the most accurate tests. The combination of Fibrotest®, Fibrometer®, or Hepascore® with Fibroscan™ or Apri increases the percentage of well classified patients from 70-73% to 80-83% for significant fibrosis, but for cirrhosis a combination offers no improvement. For the 436 patients having all the blood tests, AUROC's ranged from 0.82 (Fibrometer®) to 0.75 (Hyaluronate) for significant fibrosis, and from 0.89 (Fibrometer® and Hepascore®) to 0.83 (FIB-4) for cirrhosis. Contrarily to blood tests, performance of Fibroscan™ was reduced due to uninterpretable results. Fibrotest®, interpretable Fibroscan™, Fibrometer®, and Hepascore® perform best and similarly for diagnosis of significant fibrosis and cirrhosis. Copyright © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  19. Results of steel containment vessel model test

    International Nuclear Information System (INIS)

    Luk, V.K.; Ludwigsen, J.S.; Hessheimer, M.F.; Komine, Kuniaki; Matsumoto, Tomoyuki; Costello, J.F.

    1998-05-01

    A series of static overpressurization tests of scale models of nuclear containment structures is being conducted by Sandia National Laboratories for the Nuclear Power Engineering Corporation of Japan and the US Nuclear Regulatory Commission. Two tests are being conducted: (1) a test of a model of a steel containment vessel (SCV) and (2) a test of a model of a prestressed concrete containment vessel (PCCV). This paper summarizes the conduct of the high pressure pneumatic test of the SCV model and the results of that test. Results of this test are summarized and are compared with pretest predictions performed by the sponsoring organizations and others who participated in a blind pretest prediction effort. Questions raised by this comparison are identified and plans for posttest analysis are discussed

  20. Liver metastases: interventional therapeutic techniques and results, state of the art

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, T.J.; Mueller, P.K.; Mack, M.G.; Straub, R.; Engelmann, K. [Dept. of Radiology, Univ. of Frankfurt (Germany); Neuhaus, P. [Dept. of Surgery, Humboldt University of Berlin (Germany)

    1999-05-01

    The liver is the most common site of metastatic tumour deposits. Hepatic metastases are the major cause of morbidity and mortality in patients with gastrointestinal carcinomas and other malignant tumours. The rationale and results for interventional therapeutic techniques in the treatment of liver metastases are presented. For the treatment of patients with irresectable liver metastases, alternative local ablative therapeutic modalities have been developed. Technique and results of local interventional therapies are presented such as microwave-, radiofrequency (RF)- and ultrasound ablation, and laser-induced interstitial therapy (LITT), cryotherapy and local drug administration such as alcohol injection, endotumoral chemotherapy and regional chemoembolisation. In addition to cryotherapy, all ablative techniques can be performed percutaneously with low morbidity and mortality. Cryotherapy is an effective and precise technique for inducing tumour necrosis, but it is currently performed via laparotomy. Percutaneous local alcohol injection results in an inhomogeneous distribution in liver metastases with unreliable control rates. Local chemotherapeutic drug instillation and regional chemoembolisation produces relevant but non-reproducible lesions. Laser-induced interstitial thermotherapy (LITT) performed under MRI guidance results in precise and reproducible areas of induced necrosis with a local control of 94 %, and with an improved survival rate. Interventional therapeutic techniques of liver metastases do result in a remarkable local tumour control rate with improved survival results. (orig.) With 5 figs., 1 tab., 43 refs.

  1. Liver metastases: interventional therapeutic techniques and results, state of the art

    International Nuclear Information System (INIS)

    Vogl, T.J.; Mueller, P.K.; Mack, M.G.; Straub, R.; Engelmann, K.; Neuhaus, P.

    1999-01-01

    The liver is the most common site of metastatic tumour deposits. Hepatic metastases are the major cause of morbidity and mortality in patients with gastrointestinal carcinomas and other malignant tumours. The rationale and results for interventional therapeutic techniques in the treatment of liver metastases are presented. For the treatment of patients with irresectable liver metastases, alternative local ablative therapeutic modalities have been developed. Technique and results of local interventional therapies are presented such as microwave-, radiofrequency (RF)- and ultrasound ablation, and laser-induced interstitial therapy (LITT), cryotherapy and local drug administration such as alcohol injection, endotumoral chemotherapy and regional chemoembolisation. In addition to cryotherapy, all ablative techniques can be performed percutaneously with low morbidity and mortality. Cryotherapy is an effective and precise technique for inducing tumour necrosis, but it is currently performed via laparotomy. Percutaneous local alcohol injection results in an inhomogeneous distribution in liver metastases with unreliable control rates. Local chemotherapeutic drug instillation and regional chemoembolisation produces relevant but non-reproducible lesions. Laser-induced interstitial thermotherapy (LITT) performed under MRI guidance results in precise and reproducible areas of induced necrosis with a local control of 94 %, and with an improved survival rate. Interventional therapeutic techniques of liver metastases do result in a remarkable local tumour control rate with improved survival results. (orig.)

  2. Correlation of secretory phospholipase-A2 activity and fatty acids in cerebrospinal fluid with liver enzymes tests

    Directory of Open Access Journals (Sweden)

    Sepideh Ghodoosifar

    2016-02-01

    Full Text Available Introduction: The aim was to determine whether secretory phospholipase-A2 (sPLA2 activity and fatty acids in cerebrospinal fluid (CSF are correlated with liver enzymes tests. Methods: CSF and serum samples were collected from 49 patients (age 18-65 as part of routine diagnostic testing. Along with serum liver enzymes aspartate aminotransferase (AST, alanine aminotransferase (ALT and alkaline phosphatase (ALP, the fatty acid composition of CSF was measured by gas liquid chromatography. CSF enzyme activities of sPLA2 were measured using the standard assay with diheptanoyl thio-phosphatidylcholin as substrate. Results: The saturated fatty acids (SFAs including palmitic acid and stearic acid were positively, and the unsaturated fatty acids including oleic acid and linoleic acid were negatively correlated with liver enzymes tests. In regression analysis with adjustment for body mass index (BMI, the elevated liver enzymes tests were positively associated with activity of sPLA2 (β > 0.31, P 0.38, P < 0.010 and negatively with total monounsaturated fatty acids (MUFAs (β < -0.40, P < 0.001 contents of CSF. Conclusion: CSF activity of sPLA2 and fatty acids may be linked to peripheral markers of liver function, suggesting an indirect impact of central fatty acids on hepatocytes function and metabolism.

  3. Routine blood tests to predict liver fibrosis in chronic hepatitis C.

    Science.gov (United States)

    Hsieh, Yung-Yu; Tung, Shui-Yi; Lee, Kamfai; Wu, Cheng-Shyong; Wei, Kuo-Liang; Shen, Chien-Heng; Chang, Te-Sheng; Lin, Yi-Hsiung

    2012-02-28

    To verify the usefulness of FibroQ for predicting fibrosis in patients with chronic hepatitis C, compared with other noninvasive tests. This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), AST to platelet ratio index, cirrhosis discriminant score, age-platelet index (API), Pohl score, FIB-4 index, and Lok's model were calculated and compared. FibroQ, FIB-4, AAR, API and Lok's model results increased significantly as fibrosis advanced (analysis of variance test: P fibrosis score in chronic hepatitis C compared with other noninvasive tests. FibroQ is a simple and useful test for predicting significant fibrosis in patients with chronic hepatitis C.

  4. The PANDA facility and first test results

    International Nuclear Information System (INIS)

    Dreier, J.; Huggenberger, M.; Aubert, C.; Bandurski, T.; Fischer, O.; Healzer, J.; Lomperski, S.; Strassberger, H.J.; Varadi, G.; Yadigaroglu, G.

    1996-01-01

    The PANDA test facility at the Paul Scherrer Institute is used to study the long-term performance of the Simplified Boiling Water Reactor's passive containment cooling system. The PANDA tests demonstrate performance on a larger scale than previous tests and examine the effects of any non-uniform spatial distributions of steam and non-condensable gases in the system. The facility is in 1:1 vertical scale and 1:25 scale for volume, power etc. Extensive facility characterization tests and steady-state passive containment condenser performance tests are presented. The results of the base case test of a series of transient system behaviour tests are reviewed. The first PANDA tests exhibited reproducibility, and indicated that the Simplified Boiling Water Reactor's containment is likely to be favorably responsive and highly robust to changes in the thermal transport patterns. (orig.) [de

  5. Superconducting solenoid model magnet test results

    Energy Technology Data Exchange (ETDEWEB)

    Carcagno, R.; Dimarco, J.; Feher, S.; Ginsburg, C.M.; Hess, C.; Kashikhin, V.V.; Orris, D.F.; Pischalnikov, Y.; Sylvester, C.; Tartaglia, M.A.; Terechkine, I.; /Fermilab

    2006-08-01

    Superconducting solenoid magnets suitable for the room temperature front end of the Fermilab High Intensity Neutrino Source (formerly known as Proton Driver), an 8 GeV superconducting H- linac, have been designed and fabricated at Fermilab, and tested in the Fermilab Magnet Test Facility. We report here results of studies on the first model magnets in this program, including the mechanical properties during fabrication and testing in liquid helium at 4.2 K, quench performance, and magnetic field measurements. We also describe new test facility systems and instrumentation that have been developed to accomplish these tests.

  6. Superconducting solenoid model magnet test results

    International Nuclear Information System (INIS)

    Carcagno, R.; Dimarco, J.; Feher, S.; Ginsburg, C.M.; Hess, C.; Kashikhin, V.V.; Orris, D.F.; Pischalnikov, Y.; Sylvester, C.; Tartaglia, M.A.; Terechkine, I.; Tompkins, J.C.; Wokas, T.; Fermilab

    2006-01-01

    Superconducting solenoid magnets suitable for the room temperature front end of the Fermilab High Intensity Neutrino Source (formerly known as Proton Driver), an 8 GeV superconducting H- linac, have been designed and fabricated at Fermilab, and tested in the Fermilab Magnet Test Facility. We report here results of studies on the first model magnets in this program, including the mechanical properties during fabrication and testing in liquid helium at 4.2 K, quench performance, and magnetic field measurements. We also describe new test facility systems and instrumentation that have been developed to accomplish these tests

  7. /sup 14/C-D-galactose breath test for evaluation of liver function in patients with chronic liver disease

    Energy Technology Data Exchange (ETDEWEB)

    Caspary, W F; Schaffer, J

    1978-01-01

    D-galactose metabolism and demethylation of aminopyrine by healthy controls and patients with chronic active hepatitis (CAH) and cirrhosis (Ci), were assessed by a breath analysis technique measuring /sup 14/CO2 exhalation after oral ingestion of /sup 14/C-D-galactose or /sup 14/C-aminopyrine. Patients with CAH and Ci exhibited decreased /sup 14/CO2-exhalation rates following /sup 14/-D-galactose or /sup 14/C-aminopyrine. D-galactose oxidation capacity of the liver can be assessed by a breath analysis technique in analogy to the demethylating function for aminopyrine. The ordinary oral D-galactose tolerance test seems, however, superior in comparison to the /sup 14/C-D-galactose tolerance test, in discriminating between healthy controls and patients with chronic liver disease.

  8. Alternative filtration testing program: Pre-evaluation of test results

    International Nuclear Information System (INIS)

    Georgeton, G.K.; Poirier, M.R.

    1990-01-01

    Based on results of testing eight solids removal technologies and one pretreatment option, it is recommended that a centrifugal ultrafilter and polymeric ultrafilter undergo further testing as possible alternatives to the Norton Ceramic filters. Deep bed filtration should be considered as a third alternative, if a backwashable cartridge filter is shown to be inefficient in separate testing

  9. Alternative filtration testing program: Pre-evaluation of test results

    Energy Technology Data Exchange (ETDEWEB)

    Georgeton, G.K.; Poirier, M.R.

    1990-09-28

    Based on results of testing eight solids removal technologies and one pretreatment option, it is recommended that a centrifugal ultrafilter and polymeric ultrafilter undergo further testing as possible alternatives to the Norton Ceramic filters. Deep bed filtration should be considered as a third alternative, if a backwashable cartridge filter is shown to be inefficient in separate testing.

  10. Test results of HTTR control system

    International Nuclear Information System (INIS)

    Motegi, Toshihiro; Iigaki, Kazuhiko; Saito, Kenji; Sawahata, Hiroaki; Hirato, Yoji; Kondo, Makoto; Shibutani, Hideki; Ogawa, Satoru; Shinozaki, Masayuki; Mizushima, Toshihiko; Kawasaki, Kozo

    2006-06-01

    The plant control performance of the IHX helium flow rate control system, the PPWC helium flow rate control system, the secondary helium flow rate control system, the inlet temperature control system, the reactor power control system and the outlet temperature control system of the HTTR are obtained through function tests and power-up tests. As the test results, the control systems show stable control response under transient condition. Both of inlet temperature control system and reactor power control system shows stable operation from 30% to 100%, respectively. This report describes the outline of control systems and test results. (author)

  11. Genomic Testing and Resulting Medical Decisions

    Science.gov (United States)

    2017-10-03

    Cancer of Unknown Origin; Cancer Refractory; Cancer of Stomach; Cancer Head Neck; Cancer of Skin; Cancer, Lung; Cancer Colorectal; Cancer of Esophagus; Cancer, Bladder; Cancer, Uterus; Cancer Cervix; Cancer Liver; Cancer, Kidney; Cancer, Breast; Hematologic Neoplasms

  12. BWR Full Integral Simulation Test (FIST). Phase I test results

    International Nuclear Information System (INIS)

    Hwang, W.S.; Alamgir, M.; Sutherland, W.A.

    1984-09-01

    A new full height BWR system simulator has been built under the Full-Integral-Simulation-Test (FIST) program to investigate the system responses to various transients. The test program consists of two test phases. This report provides a summary, discussions, highlights and conclusions of the FIST Phase I tests. Eight matrix tests were conducted in the FIST Phase I. These tests have investigated the large break, small break and steamline break LOCA's, as well as natural circulation and power transients. Results and governing phenomena of each test have been evaluated and discussed in detail in this report. One of the FIST program objectives is to assess the TRAC code by comparisons with test data. Two pretest predictions made with TRACB02 are presented and compared with test data in this report

  13. Radiofrequency ablation of liver tumors by using monopolar perfusion electrode:an analysis of therapeutic results

    International Nuclear Information System (INIS)

    Luo Rongguang; Gu Yangkui; Gao Fei; Zhang Liang; Zhao Ming; Fan Weijun; Wu Peihong; Huang Jinhua

    2010-01-01

    Objective: To investigate the clinical value of CT-guided radiofrequency ablation by using monopolar perfusion electrode in treating liver tumors. Methods: From January 2008 to December 2008, 24 patients with 37 lesions of liver tumors were treated with radiofrequency ablation by using monopolar perfusion electrode (RITA UniBlate). Of the 24 patients,solitary lesion was seen in 14, two lesions in 7 and three lesions in 3. Among 37 lesions,the maximum diameter of the lesion ≤ 3 cm, 3.1∼5 cm and > 5 cm was determined in 24, 8 and 5, respectively. The changes of the tumor size and the AFP level were observed. A follow-up lasting for 12 months was conducted. Results: After radiofrequency ablation twenty-two lesions (22/37, 59.5%) were completely ablated, of which nineteen tumors (19/24, 79.2%) were smaller than 3 cm in diameter, two tumors (2 / 8, 25%) had a diameter between 3.1 cm and 5 cm, one tumor (1 / 5, 20%) was larger than 5 cm. Fifteen tumors (15 / 37, 40.5%) were not completely ablated. During the follow-up period of 12 months, fifteen patients (15 / 24, 62.5%) remained alive and nine patients died, of whom the survival time was less than 6 months in six and was 6 -12 months in 4. After radiofrequency ablation, the AFP level decreased to normal level in 5 patients (5 / 10, 50%), and mild decrease of AFP, but still higher than normal,was seen in 3 patients (3 / 10, 30%). Of 10 patients who had a positive AFP test, 2 (2 / 10, 10%) showed a continuous rise in the AFP level. After radiofrequency ablation, one patient developed a minor hepatic subcapsular bleeding,and all patients complained of different degrees of fever and upper abdominal pain. Conclusion: CT-guided radiofrequency ablation by using monopolar perfusion electrode is a minimally-invasive technique with reliable short-term results and fewer complications. Therefore, it is a safe and effective local treatment for liver cancer. For tumors smaller than 3 cm in diameter complete ablation can be

  14. SULTAN test facility: Summary of recent results

    International Nuclear Information System (INIS)

    Stepanov, Boris; Bruzzone, Pierluigi; Sedlak, Kamil; Croari, Giancarlo

    2013-01-01

    The test campaigns of the ITER conductors in the SULTAN test facility re-started in December 2011 after three months break. The main focus of the activities is about the qualification tests of the Central Solenoid (CS) conductors, with three different samples for a total six variations of strand suppliers and cable layouts. In 2012, five Toroidal Field (TF) conductor samples have also been tested as part of the supplier and process qualification phase of the European, Korean, Chinese and Russian Federation Agencies. A summary of the test results for all the ITER samples tested in the last period is presented, including an updated statistics of the broad transition, the performance degradation and the impact of layout variations. The role of SULTAN test facility during the ITER construction is reviewed, and the load of work for the next three years is anticipated

  15. Production LHC HTS power lead test results

    CERN Document Server

    Tartaglia, M; Fehér, S; Huang, Y; Orris, D F; Pischalnikov, Y; Rabehl, Roger Jon; Sylvester, C D; Zbasnik, J

    2005-01-01

    The Fermilab Magnet test facility has built and operated a test stand to characterize the performance of HTS power leads. We report here the results of production tests of 20 pairs of 7.5 kA HTS power leads manufactured by industry for installation in feed boxes for the LHC Interaction Region quadrupole strings. Included are discussions of the thermal, electrical, and quench characteristics under "standard" and "extreme" operating conditions, and the stability of performance across thermal cycles.

  16. Production LHC HTS power lead test results

    International Nuclear Information System (INIS)

    Tartaglia, M.A.; Carcagno, R.H.; Feher, S.; Huang, Y.; Orris, D.F.; Pischalnikov, Y.; Rabehl, R.J.; Sylvester, C.; Zbasnik, J.

    2004-01-01

    The Fermilab Magnet test facility has built and operated a test stand to characterize the performance of HTS power leads. We report here the results of production tests of 20 pairs of 7.5 kA HTS power leads manufactured by industry for installation in feed boxes for the LHC Interaction Region quadrupole strings. Included are discussions of the thermal, electrical, and quench characteristics under ''standard'' and ''extreme'' operating conditions, and the stability of performance across thermal cycles

  17. Evolution of noninvasive tests of liver fibrosis is associated with prognosis in patients with chronic hepatitis C.

    Science.gov (United States)

    Vergniol, Julien; Boursier, Jérôme; Coutzac, Clélia; Bertrais, Sandrine; Foucher, Juliette; Angel, Camille; Chermak, Faiza; Hubert, Isabelle Fouchard; Merrouche, Wassil; Oberti, Frédéric; de Lédinghen, Victor; Calès, Paul

    2014-07-01

    No data are available about the prediction of long-term survival using repeated noninvasive tests of liver fibrosis in chronic hepatitis C (CHC). We aimed to assess the prognostic value of 3-year liver stiffness measurement (LSM), aspartate aminotransferase to platelet ratio index (APRI), and fibrosis 4 (FIB-4) evolution in CHC. CHC patients with two LSM (1,000-1,500 days interval) were prospectively included. Blood fibrosis tests APRI and FIB-4 were calculated the day of baseline (bLSM) and follow-up (fLSM) LSM. Evolution of fibrosis tests was expressed as delta: (follow-up-baseline results)/duration. Date and cause of death were recorded during follow-up that started the day of fLSM. In all, 1,025 patients were included. Median follow-up after fLSM was 38.0 months (interquartile range [IQR]: 27.7-46.1) during which 35 patients died (14 liver-related death) and seven had liver transplantation. Prognostic accuracy (Harrell C-index) of multivariate models including baseline and delta results was not significantly different between LSM and FIB-4 (P ≥ 0.24), whereas FIB-4 provided more accurate prognostic models than APRI (P = 0.03). By multivariate analysis including LSM variables, overall survival was independently predicted by bLSM, delta (dLSM), and sustained virological response (SVR). Prognosis was excellent in patients having bLSM 0 kPa/year) in ≥ 14 kPa bLSM had the worst prognosis. Baseline and delta FIB-4 also identified patient subgroups with significantly different prognosis. Three-year evolution of noninvasive tests of liver fibrosis has a strong prognostic value in CHC patients. These tests should be repeated to monitor patients and predict their outcome. © 2014 by the American Association for the Study of Liver Diseases.

  18. Accuracy of the Enhanced Liver Fibrosis Test vs Fibrotest, Elastography and Indirect Markers in Detection of Advanced Fibrosis in Patients with Alcoholic Liver Disease

    DEFF Research Database (Denmark)

    Thiele, Maja; Madsen, Bjørn Stæhr; Hansen, Janne Fuglsang

    2018-01-01

    BACKGROUND & AIMS: Alcohol is the leading cause of cirrhosis and liver-related mortality, but we lack serum markers to detect compensated disease. We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the FibroTest, liver stiffness measurements (made by transient elastography and 2......-dimensional shear-wave elastography), and 6 indirect marker tests in detection of advanced liver fibrosis (Kleiner stage ≥F3). METHODS: We performed a prospective study of 10 liver fibrosis markers (patented and not), all performed on the same day. Patients were recruited from primary centers (municipal...... significantly from those of liver stiffness measurement in intention-to-diagnose analyses (AUROC for transient elastography, 0.90), but did differ in the per-protocol analysis (AUROC for transient elastography, 0.97) (P=.521 and .004 for comparison with ELF). Adding a serum marker to transient elastography...

  19. Influence of Prescribed Herbal and Western Medicine on Patients with Abnormal Liver Function Tests: A Retrospective Quasi-Experimental Study

    Science.gov (United States)

    Lee, Ah-Ram; Yim, Je-Min; Kim, Won-Il

    2012-01-01

    Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal, western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients’, moreover, it was shown to be effective in patients with abnormal liver function tests. PMID:25780634

  20. Local Treatment of Unresectable Colorectal Liver Metastases: Results of a Randomized Phase II Trial.

    Science.gov (United States)

    Ruers, Theo; Van Coevorden, Frits; Punt, Cornelis J A; Pierie, Jean-Pierre E N; Borel-Rinkes, Inne; Ledermann, Jonathan A; Poston, Graeme; Bechstein, Wolf; Lentz, Marie-Ange; Mauer, Murielle; Folprecht, Gunnar; Van Cutsem, Eric; Ducreux, Michel; Nordlinger, Bernard

    2017-09-01

    Tumor ablation is often employed for unresectable colorectal liver metastases. However, no survival benefit has ever been demonstrated in prospective randomized studies. Here, we investigate the long-term benefits of such an aggressive approach. In this randomized phase II trial, 119 patients with unresectable colorectal liver metastases (n  38%) was met. We now report on long-term OS results. All statistical tests were two-sided. The analyses were according to intention to treat. At a median follow up of 9.7 years, 92 of 119 (77.3%) patients had died: 39 of 60 (65.0%) in the combined modality arm and 53 of 59 (89.8%) in the systemic treatment arm. Almost all patients died of progressive disease (35 patients in the combined modality arm, 49 patients in the systemic treatment arm). There was a statistically significant difference in OS in favor of the combined modality arm (hazard ratio [HR] = 0.58, 95% confidence interval [CI] = 0.38 to 0.88, P = .01). Three-, five-, and eight-year OS were 56.9% (95% CI = 43.3% to 68.5%), 43.1% (95% CI = 30.3% to 55.3%), 35.9% (95% CI = 23.8% to 48.2%), respectively, in the combined modality arm and 55.2% (95% CI = 41.6% to 66.9%), 30.3% (95% CI = 19.0% to 42.4%), 8.9% (95% CI = 3.3% to 18.1%), respectively, in the systemic treatment arm. Median OS was 45.6 months (95% CI = 30.3 to 67.8 months) in the combined modality arm vs 40.5 months (95% CI = 27.5 to 47.7 months) in the systemic treatment arm. This phase II trial is the first randomized study demonstrating that aggressive local treatment can prolong OS in patients with unresectable colorectal liver metastases. © The Author 2017. Published by Oxford University Press.

  1. Nuclear medicine liver-function tests for pregnant women and children. Pt. 2

    International Nuclear Information System (INIS)

    Krumbiegel, P.; Hirschberg, K.; Faust, H.; Guenther, K.; Schneider, G.

    1985-01-01

    A simple, non-invasive, non-radiaoactive liver-function test is proposed. After an oral dose of 3 mg methacetin per kilogram body mass, the kinetics of 15 N excretion via urine were characterized by the quotient of the 15 N amounts of excreted in two successive urine samples (Q value). The stable nitrogen isotope 15 N, was found to be an excellent and easily detectable indicator of the sum of all methacetin metabolites present in urine. Alterations in the nature or ratio of methacetin metabilites due to liver diseases could not be found. From the investigation of 11 men 3 pregnant women and 156 children, a clear difference was observed in Q values of healthy persons and patients suffering from liver-cell-activity diseases. The discriminating power of our new liver-function test is shown to be equivalent to that of the 14 CO 2 breath test. (orig.)

  2. Reproducibility of the results in nondestructive testing

    International Nuclear Information System (INIS)

    Launay, J.P.; Chalaye, H.; Thomas, A.

    1980-10-01

    Pressure vessels must comply with very severe safety criteria. In order to ensure that the required quality is attained, non destructive tests are used and these have to be highly reliable: magnetoscopy and liquid penetration for surface examinations, radiography and ultrasonics for voluminal examinations. In the case of ultrasonic examinations, a study of parameters has been made and a statistical analysis of the results has made it possible to calculate the dispersion due to the testing equipment [fr

  3. Acknowledging the results of blood tests

    DEFF Research Database (Denmark)

    Torkilsheyggi, Arnvør Martinsdottir á; Hertzum, Morten

    At the studied hospital, physicians from the Medical and Surgical Departments work some of their shifts in the Emergency Department (ED). Though icons showing the blood-test process were introduced on electronic whiteboards in the ED, these icons did not lead to increased attention to test acknow...... acknowledgement. Rather, the physicians, trans-ferred work practices from their own departments, which did not have electronic white-boards, to the ED. This finding suggests a challenge to the cross-disciplinary work and norms for how to follow up on blood-test results in the ED....

  4. Correlation between liver function tests and metabolic syndrome in hepatitis-free elderly

    Directory of Open Access Journals (Sweden)

    Hung-Sheng Shang

    2015-01-01

    Full Text Available Background: We aimed to investigate the relationship between liver function tests (LFTs and metabolic syndrome (MetS as several studies have shown positive correlations between some of the LFTs, including alanine aminotransferase (ALT and γ-glutamyl transpeptidase (γ-GT, and MetS but have not fully explored the same in the elderly. Owing to the progress in public health, the aging of the general population becomes a major issue. Design: We enrolled subjects aged over 60 years who underwent routine health checkups in a Health Screening Center after excluding subjects with a history of hepatitis B or C infection, excessive alcohol consumption, liver fibrosis, cirrhosis, acute hepatitis, diabetes, hypertension, dyslipidemia, cardiovascular disease, or receiving medications for these diseases. Finally, 9,282 participants were eligible for analysis. Statistical Analysis: All data were tested for normal distribution with the Kolmogorov-Smirnov test and for homogeneity of variances with the Levene′s test. A t-test was used to evaluate the differences between the two groups. Univariate and multivariate regressions were used to observe correlations between different parameters. Receiver operating characteristic curves of each LFT were used to predict MetS. Areas under curves and 95% confidence interval were also estimated and compared. Results: With the exception of aspartate aminotransferase and α-fetal protein, the results of LFTs, including total and direct bilirubin, alkaline phosphatase (ALP, ALT, and γ-GT, were altered in the group with MetS. Furthermore, the levels of γ-GT in men and ALP in women were independently associated with all MetS components and had the highest areas under receiver operating characteristic curves. Conclusion: Abnormal LFTs are highly correlated with MetS in the hepatitis-free elderly, with levels of γ-GT in men and ALP in women being the most important factors. LFTs may represent an auxiliary tool for the

  5. Ultrasound versus liver function tests for diagnosis of common bile duct stones.

    Science.gov (United States)

    Gurusamy, Kurinchi Selvan; Giljaca, Vanja; Takwoingi, Yemisi; Higgie, David; Poropat, Goran; Štimac, Davor; Davidson, Brian R

    2015-02-26

    Ultrasound and liver function tests (serum bilirubin and serum alkaline phosphatase) are used as screening tests for the diagnosis of common bile duct stones in people suspected of having common bile duct stones. There has been no systematic review of the diagnostic accuracy of ultrasound and liver function tests. To determine and compare the accuracy of ultrasound versus liver function tests for the diagnosis of common bile duct stones. We searched MEDLINE, EMBASE, Science Citation Index Expanded, BIOSIS, and Clinicaltrials.gov to September 2012. We searched the references of included studies to identify further studies and systematic reviews identified from various databases (Database of Abstracts of Reviews of Effects, Health Technology Assessment, Medion, and ARIF (Aggressive Research Intelligence Facility)). We did not restrict studies based on language or publication status, or whether data were collected prospectively or retrospectively. We included studies that provided the number of true positives, false positives, false negatives, and true negatives for ultrasound, serum bilirubin, or serum alkaline phosphatase. We only accepted studies that confirmed the presence of common bile duct stones by extraction of the stones (irrespective of whether this was done by surgical or endoscopic methods) for a positive test result, and absence of common bile duct stones by surgical or endoscopic negative exploration of the common bile duct, or symptom-free follow-up for at least six months for a negative test result as the reference standard in people suspected of having common bile duct stones. We included participants with or without prior diagnosis of cholelithiasis; with or without symptoms and complications of common bile duct stones, with or without prior treatment for common bile duct stones; and before or after cholecystectomy. At least two authors screened abstracts and selected studies for inclusion independently. Two authors independently collected data from

  6. Clinical evaluation of serum bile acids as a new liver function test

    Energy Technology Data Exchange (ETDEWEB)

    Biffl, H; Pristautz, H; Parsche, P; Passath, A; Leb, G [Graz Univ. (Austria). Medizinische Klinik

    1980-01-01

    In a randomized patient material, with various histologically verified hepatobiliary diseases, the serum levels of Cholyl glycine (CG) and Sulfolithocholyl glycine (SLCG) were compared with each other. SLCG levels are a more sensitive parameter and permit a more significant differentiation between fatty and normal livers and between cases with and without portal hypertension in liver cirrhosis. There were poor correlations between the hitherto routinely performed laboratory tests and the SLCG levels, but good correlations between SLCG and defined parenchymal liver diseases. The publication ends with the presentation of a newly developed SLCG-stimulation test, which provides a staging of parenchymal liver diseases without unnecessary requirements of time and material and with minimal stress to the patients.

  7. Results of interlaboratory tests regarding TXRF

    International Nuclear Information System (INIS)

    Klockenkaemper, R.; Bohlen, A. von

    2000-01-01

    Interlaboratory or intercomparison tests can be performed for proficiency testing of individual laboratories, for the certification of a special sample material and for the validation of a certain method. We participated in two interlaboratory tests in order to validate total reflection x-ray fluorescence analysis (TXRF). We used our results to evaluate TXRF and to compare it with other competing methods, particularly with respect of precision and accuracy. The first interlaboratory test was organized by IAEA (International Atomic Energy Agency, Vienna, Austria). As a candidate for reference material, a lichen (IAEA-336 Lichen) was distributed among 27 participants. In our laboratory, the powdered biogenic material was digested with nitric acid under high pressure and analyzed by TXRF. - The second interlaboratory test was organized by IRMM (Institute for Reference Materials and Measurements, Geel, Belgium). As a certified test sample with undisclosed values, a sediment (IMEP-14) was delivered to 220 laboratories. We digested the geogenic material again by nitric acid and additionally by hydrofluoric acid and analyzed it by TXRF. - In both test samples, six or eight different trace elements, respectively, were determined by TXRF with a content between 2 and 2000 mg/kg. Calibration was carried out by internal standardization. For that purpose, Ga or Se, respectively, was added as standard element. The measurement uncertainty of TXRF was estimated by the method of error propagation. In our paper we will report on the results of the two interlaboratory tests. It will be shown that TXRF is highly reliable for a correct determination of trace elements in biogenic and geogenic samples. It is competitive with the established methods of trace analyses which were involved in these tests and it is even superior to them in certain aspects. (author)

  8. Test Results of PBMR Fuel Spheres

    International Nuclear Information System (INIS)

    Koshcheev, Konstantin; Diakov, Alexander; Beltyukov, Igor; Barybin, Andrey; Chernetsov, Mikhail

    2014-01-01

    Results of pre-irradiation testing of fuel spheres (FS) and coated particles (CP) manufactured by PBMR SOC (Republic of South Africa) are described. The stable high quality level of major characteristics (dimensions, CP coating structure, uranium-235 contamination of the FS matrix graphite and the outer PyC layer of the CP coating) are shown. Results of a methodical irradiation test of two FS in helium and neon medium at temperatures of 800 to 1300 °C with simultaneous determination of release-to-birth ratios for major gaseous fission products (GFP) are described. (author)

  9. Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers

    NARCIS (Netherlands)

    Swart, P J; Hirano, T; Kuipers, M E; Ito, Y; Smit, C; Hashida, M; Nishikawa, M; Beljaars, L; Meijer, D K; Poelstra, K

    1999-01-01

    Background/Aims: The rapid clearance from plasma and the limited uptake of superoxide dismutase (SOD) in the liver hampers the effectiveness of this enzyme in liver diseases. We therefore compared the pharmacokinetics and in vivo efficacy of SOD with two modified forms of this protein: SOD coupled

  10. Cascade Distiller System Performance Testing Interim Results

    Science.gov (United States)

    Callahan, Michael R.; Pensinger, Stuart; Sargusingh, Miriam J.

    2014-01-01

    The Cascade Distillation System (CDS) is a rotary distillation system with potential for greater reliability and lower energy costs than existing distillation systems. Based upon the results of the 2009 distillation comparison test (DCT) and recommendations of the expert panel, the Advanced Exploration Systems (AES) Water Recovery Project (WRP) project advanced the technology by increasing reliability of the system through redesign of bearing assemblies and improved rotor dynamics. In addition, the project improved the CDS power efficiency by optimizing the thermoelectric heat pump (TeHP) and heat exchanger design. Testing at the NASA-JSC Advanced Exploration System Water Laboratory (AES Water Lab) using a prototype Cascade Distillation Subsystem (CDS) wastewater processor (Honeywell d International, Torrance, Calif.) with test support equipment and control system developed by Johnson Space Center was performed to evaluate performance of the system with the upgrades as compared to previous system performance. The system was challenged with Solution 1 from the NASA Exploration Life Support (ELS) distillation comparison testing performed in 2009. Solution 1 consisted of a mixed stream containing human-generated urine and humidity condensate. A secondary objective of this testing is to evaluate the performance of the CDS as compared to the state of the art Distillation Assembly (DA) used in the ISS Urine Processor Assembly (UPA). This was done by challenging the system with ISS analog waste streams. This paper details the results of the AES WRP CDS performance testing.

  11. [Changes in serotonin and noradrenaline in hepatic encephalopathy as a result of liver failure in rat].

    Science.gov (United States)

    Song, Min-ning; Song, Yu-na; Chen, Fu; Luo, Mei-lan

    2007-01-01

    To investigate the changes in serotonin (5-HT) and noradrenaline (NA) in hepatic encephalopathy as a result of acute and chronic liver failure in rat. One hundred and ten Sprague-Dawley (SD) rats were randomly divided into groups of normal control (n=20), experimental group of acute liver failure (ALF) encephalopathy (n=45), and experimental group of chronic liver failure (CLF) encephalopathy (n=45). Two dosages of thioacetamide (TAA) of 500 mg/kg were gavaged with an interval of 24 hours to reproduce ALF model. To reproduce CLF model rats were fed with 0.03% TAA in drinking water for 10 weeks, and 50% of TAA dosage was added or withheld according to the change in weekly body weight measurement. Animals were sacrificed and venous blood specimens were obtained after successful replication of model, and 5-HT, NA, ammonia, parameters of liver function were determined, and liver and brain were studied pathologically. The experiment showed that the liver functions of rats in groups ALF encephalopathy and CLF encephalopathy deteriorated seriously, changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), albumen (ALB), ALB/globulin (A/G), and blood ammonia were observed(Pliver and brain pathologies were identical to those of ALF and CLF encephalopathy. The values of 5-HT were increased in groups ALF encephalopathy and CLF encephalopathy [(16.06+/-1.08) micromol/L and (15.32+/-1.48) micromol/L] compared with the normal group [(2.75+/-0.26) micromol/L, both Pencephalopathy [(94.0+/-2.13) pmol/L vs.(121.2+/-14.8) pmol/L,Pencephalopathy and CLF encephalopathy. The content of NA decreases remarkably in CLF encephalopathy.

  12. ALICE TRD results from prototype tests

    CERN Document Server

    Andronic, A; Blume, C; Braun-Munzinger, P; Bucher, D; Catanescu, G; Ciobanu, M; Daues, H W; Devismes, A; Finck, C; Herrmann, N; Lister, T A; Mahmoud, Tariq; Peitzmann, Thomas; Petrovici, M; Reygers, K; Santo, R; Schicker, R; Sedykha, S; Simon, R S; Stachel, J; Stelzer, H; Wessels, J P; Winkelmann, O; Windelband, B; Xu, C

    2002-01-01

    We present results from tests of a prototype of the TRD for the ALICE experiment at LHC. We investigate the performance-of different radiator types, composed of foils, fibres and foams. The pion rejection performance for different methods of analysis over a momentum range from 0.7 to 2 GeV/c is presented. (8 refs).

  13. SLD liquid argon calorimeter prototype test results

    International Nuclear Information System (INIS)

    Dubois, R.; Eigen, G.; Au, Y.

    1985-10-01

    The results of the SLD test beam program for the selection of a calorimeter radiator composition within a liquid argon system are described, with emphasis on the study of the use of uranium to obtain equalization of pion and electron responses

  14. Cone Penetrometer N Factor Determination Testing Results

    Energy Technology Data Exchange (ETDEWEB)

    Follett, Jordan R.

    2014-03-05

    This document contains the results of testing activities to determine the empirical 'N Factor' for the cone penetrometer in kaolin clay simulant. The N Factor is used to releate resistance measurements taken with the cone penetrometer to shear strength.

  15. Ball Aerospace SBMD Coating Test Results

    Science.gov (United States)

    Brown, Robert; Lightsey, Paul; Russell, J. Kevin (Technical Monitor)

    2002-01-01

    The Sub-scale Beryllium Mirror Demonstrator that was successfully tested to demonstrate cryogenic figuring of a bare mirror has been coated with a protected gold reflective surface and retested at cryogenic temperatures. Results showing less than 9 nm rms surface distortion attributable to the added coating are presented.

  16. Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy.

    Science.gov (United States)

    Itoh, Satoru; Hattori, Chiharu; Nagata, Mayumi; Sanbuissho, Atsushi

    2012-08-30

    The liver micronucleus test is an important method to detect pro-mutagens such as active metabolites not reaching bone marrow due to their short lifespan. We have already reported that dosing of the test compound after partial hepatectomy (PH) is essential to detect genotoxicity of numerical chromosome aberration inducers in mice [Mutat. Res. 632 (2007) 89-98]. In naive animals, the proportion of binucleated cells in rats is less than half of that in mice, which suggests a species difference in the response to chromosome aberration inducers. In the present study, we investigated the responses to structural and numerical chromosome aberration inducers in the rat liver micronucleus test. Two structural chromosome aberretion inducers (diethylnitrosamine and 1,2-dimethylhydrazine) and two numerical chromosome aberration inducers (colchicine and carbendazim) were used in the present study. PH was performed a day before or after the dosing of the test compound in 8-week old male F344 rats and hepatocytes were isolated 4 days after the PH. As a result, diethylnitrosamine and 1,2-dimethylhydrazine, structural chromosome aberration inducers, exhibited significant increase in the incidence of micronucleated hepatocyte (MNH) when given either before and after PH. Colchicine and carbendazim, numerical chromosome aberration inducers, did not result in any toxicologically significant increase in MNH frequency when given before PH, while they exhibited MNH induction when given after PH. It is confirmed that dosing after PH is essential in order to detect genotoxicity of numerical chromosome aberration inducers in rats as well as in mice. Regarding the species difference, a different temporal response to colchicine was identified. Colchicine increased the incidence of MNH 4 days after PH in rats, although such induction in mice was observed 8-10 days after PH. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* study.

    Science.gov (United States)

    Scorletti, Eleonora; Bhatia, Lokpal; McCormick, Keith G; Clough, Geraldine F; Nash, Kathryn; Hodson, Leanne; Moyses, Helen E; Calder, Philip C; Byrne, Christopher D

    2014-10-01

    There is no licensed treatment for non-alcoholic fatty liver disease (NAFLD), a condition that increases risk of chronic liver disease, type 2 diabetes and cardiovascular disease. We tested whether 15-18 months treatment with docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (Omacor/Lovaza) (4 g/day) decreased liver fat and improved two histologically-validated liver fibrosis biomarker scores (primary outcomes). Patients with NAFLD were randomised in a double blind placebo-controlled trial [DHA+EPA(n=51), placebo(n=52)]. We quantified liver fat percentage (%) by magnetic resonance spectroscopy in three liver zones. We measured liver fibrosis using two validated scores. We tested adherence to the intervention (Omacor group) and contamination (with DHA and EPA) (placebo group) by measuring erythrocyte percentage DHA and EPA enrichment (gas chromatography). We undertook multivariable linear regression to test effects of: a) DHA+EPA treatment (ITT analyses) and b) erythrocyte DHA and EPA enrichment (secondary analysis). Median (IQR) baseline and end of study liver fat% were 21.7 (19.3) and 19.7 (18.0) (placebo), and 23.0 (36.2) and 16.3 (22.0), (DHA+EPA). In the fully adjusted regression model there was a trend towards improvement in liver fat% with DHA+EPA treatment (β=-3.64 (95%CI -8.0,0.8); p=0.1) but there was evidence of contamination in the placebo group and variable adherence to the intervention in the Omacor group. Further regression analysis showed that DHA enrichment was independently associated with a decrease in liver fat% (for each 1% enrichment, β=-1.70 (95%CI -2.9,-0.5); p=0.007). No improvement in the fibrosis scores occurred. Conclusion. Erythrocyte DHA enrichment with DHA+EPA treatment is linearly associated with decreased liver fat%. Substantial decreases in liver fat% can be achieved with high percentage erythrocyte DHA enrichment in NAFLD. (Hepatology 2014;).

  18. A liver-function test using 15N-labelled ammonium chloride

    International Nuclear Information System (INIS)

    Jung, K.; Hirscherg, K.; Faust, H.; Matkowitz, R.

    1985-01-01

    Malfunction of the liver involves disturbances of urea synthesis and ammonia detoxification. These phenomena became apparent, especially during ammonia loading of patients. The functional state of the liver can be assessed by oral administration of 15 NH 4 Cl and subsequent analysis of 15 N-urea and 15 N-ammonia in urine by emission spectrometry. Clinical tests based on the ratio of the excess abundances (see Appendix) of 15 N-ammonia to 15 N-urea excreted in urine 3 h after oral administration gave values for patients with liver disease which differed significantly from those for healthy subjects. Absorption disturbances, which often accompany liver diseases, do not influence the effectiveness of the method. (orig.)

  19. Liver-function test using /sup 15/N-labelled ammonium chloride

    Energy Technology Data Exchange (ETDEWEB)

    Jung, K; Hirscherg, K; Faust, H; Matkowitz, R

    1985-08-01

    Malfunction of the liver involves disturbances of urea synthesis and ammonia detoxification. These phenomena became apparent, especially during ammonia loading of patients. The functional state of the liver can be assessed by oral administration of /sup 15/NH/sub 4/Cl and subsequent analysis of /sup 15/N-urea and /sup 15/N-ammonia in urine by emission spectrometry. Clinical tests based on the ratio of the excess abundances (see Appendix) of /sup 15/N-ammonia to /sup 15/N-urea excreted in urine 3 h after oral administration gave values for patients with liver disease which differed significantly from those for healthy subjects. Absorption disturbances, which often accompany liver diseases, do not influence the effectiveness of the method.

  20. Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients

    DEFF Research Database (Denmark)

    Schmidt, L E; Olsen, A K; Stentoft, K

    2001-01-01

    BACKGROUND: Interindividual variation in the pharmacokinetics of the immunosuppressive agents cyclosporine (INN, ciclosporin) and tacrolimus may result from differences in the activity of cytochrome P4503A (CYP3A). The erythromycin breath test is an in vivo assay of hepatic CYP3A activity......, but the method has never been directly validated. The aim of the study was to investigate whether an early postoperative erythromycin breath test correlated with the hepatic CYP3A protein level and catalytic activity in liver transplant recipients. METHODS: In 18 liver transplant recipients, the erythromycin...... breath test was performed within 2 hours after transplantation. A graft biopsy was obtained during surgery and analyzed for the CYP3A protein level by Western blotting and for CYP3A activity with erythromycin demethylation and testosterone 6beta- hydroxylation assays. RESULTS: The erythromycin breath...

  1. Laboratory results of the AOF system testing

    Science.gov (United States)

    Kolb, Johann; Madec, Pierre-Yves; Arsenault, Robin; Oberti, Sylvain; Paufique, Jérôme; La Penna, Paolo; Ströbele, Stefan; Donaldson, Robert; Soenke, Christian; Suárez Valles, Marcos; Kiekebusch, Mario; Argomedo, Javier; Le Louarn, Miska; Vernet, Elise; Haguenauer, Pierre; Duhoux, Philippe; Aller-Carpentier, Emmanuel; Valenzuela, Jose Javier; Guerra, Juan Carlos

    2016-07-01

    For two years starting in February 2014, the AO modules GRAAL for HAWK-I and GALACSI for MUSE of the Adaptive Optics Facility project have undergone System Testing at ESO's Headquarters. They offer four different modes: NGS SCAO, LGS GLAO in the IR, LGS GLAO and LTAO in the visible. A detailed characterization of those modes was made possible by the existence of ASSIST, a test bench emulating an adaptive VLT including the Deformable Secondary Mirror, a star simulator and turbulence generator and a VLT focal plane re-imager. This phase aimed at validating all the possible components and loops of the AO modules before installation at the actual VLT that comprises the added complexity of real LGSs, a harsher non-reproducible environment and the adaptive telescope control. In this paper we present some of the major results obtained and challenges encountered during the phase of System Tests, like the preparation of the Acquisition sequence, the testing of the Jitter loop, the performance optimization in GLAO and the offload of low-order modes from the DSM to the telescope (restricted to the M2 hexapod). The System Tests concluded with the successful acceptance, shipping, installation and first commissioning of GRAAL in 2015 as well as the acceptance and shipping of GALACSI, ready for installation and commissioning early 2017.

  2. Benign Liver Tumors

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  3. Progression of Liver Disease

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  4. Liver (Hepatocellular) Cancer Screening

    Science.gov (United States)

    ... Treatment Liver Cancer Prevention Liver Cancer Screening Research Liver (Hepatocellular) Cancer Screening (PDQ®)–Patient Version What is ... These are called diagnostic tests . General Information About Liver (Hepatocellular) Cancer Key Points Liver cancer is a ...

  5. Boeing's STAR-FODB test results

    Science.gov (United States)

    Fritz, Martin E.; de la Chapelle, Michael; Van Ausdal, Arthur W.

    1995-05-01

    Boeing has successfully concluded a 2 1/2 year, two phase developmental contract for the STAR-Fiber Optic Data Bus (FODB) that is intended for future space-based applications. The first phase included system analysis, trade studies, behavior modeling, and architecture and protocal selection. During this phase we selected AS4074 Linear Token Passing Bus (LTPB) protocol operating at 200 Mbps, along with the passive, star-coupled fiber media. The second phase involved design, build, integration, and performance and environmental test of brassboard hardware. The resulting brassboard hardware successfully passed performance testing, providing 200 Mbps operation with a 32 X 32 star-coupled medium. This hardware is suitable for a spaceflight experiment to validate ground testing and analysis and to demonstrate performace in the intended environment. The fiber bus interface unit (FBIU) is a multichip module containing transceiver, protocol, and data formatting chips, buffer memory, and a station management controller. The FBIU has been designed for low power, high reliability, and radiation tolerance. Nine FBIUs were built and integrated with the fiber optic physical layer consisting of the fiber cable plant (FCP) and star coupler assembly (SCA). Performance and environmental testing, including radiation exposure, was performed on selected FBIUs and the physical layer. The integrated system was demonstrated with a full motion color video image transfer across the bus while simultaneously performing utility functions with a fiber bus control module (FBCM) over a telemetry and control (T&C) bus, in this case AS1773.

  6. Results from the CLIC Test Facility

    CERN Document Server

    Braun, H; Bossart, Rudolf; Chautard, F; Corsini, R; Delahaye, J P; Godot, J C; Hutchins, S; Kamber, I; Madsen, J H B; Rinolfi, Louis; Rossat, G; Schreiber, S; Suberlucq, Guy; Thorndahl, L; Wilson, Ian H; Wuensch, Walter

    1996-01-01

    In order to study the principle of the Compact Linear Collider (CLIC) based on the Two Beam Acceleration (TBA) scheme at high frequency, a CLIC Test Facility (CTF) has been set-up at CERN. After four years of successful running, the experimental programme is now fully completed and all its objectives reached, particularly the generation of a high intensity drive beam with short bunches by a photo-injector, the production of 30 GHz RF power and the acceleration of a probe beam by 30 GHz structures. A summary of the CTF results and their impact on linear collider design is given. This covers 30 GHz high power testing, study of intense, short single bunches; as well as RF-Gun, photocathode and beam diagnostic developments. A second phase of the test facility (CTF2) is presently being installed to demonstrate the feasibility of the TBA scheme by constructing a fully engineered, 10 m long, test section very similar to the CLIC drive and main linacs, producing up to 480 MW of peak RF power at 30 GHz and acceleratin...

  7. The Benchmark Test Results of QNX RTOS

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jang Yeol; Lee, Young Jun; Cheon, Se Woo; Lee, Jang Soo; Kwon, Kee Choon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2010-10-15

    A Real-Time Operating System(RTOS) is an Operating System(OS) intended for real-time applications. Benchmarking is a point of reference by which something can be measured. The QNX is a Real Time Operating System(RTOS) developed by QSSL(QNX Software Systems Ltd.) in Canada. The ELMSYS is the brand name of commercially available Personal Computer(PC) for applications such as Cabinet Operator Module(COM) of Digital Plant Protection System(DPPS) and COM of Digital Engineered Safety Features Actuation System(DESFAS). The ELMSYS PC Hardware is being qualified by KTL(Korea Testing Lab.) for use as a Cabinet Operator Module(COM). The QNX RTOS is being dedicated by Korea Atomic Energy Research Institute (KAERI). This paper describes the outline and benchmarking test results on Context Switching, Message Passing, Synchronization and Deadline Violation of QNX RTOS under the ELMSYS PC platform

  8. The Benchmark Test Results of QNX RTOS

    International Nuclear Information System (INIS)

    Kim, Jang Yeol; Lee, Young Jun; Cheon, Se Woo; Lee, Jang Soo; Kwon, Kee Choon

    2010-01-01

    A Real-Time Operating System(RTOS) is an Operating System(OS) intended for real-time applications. Benchmarking is a point of reference by which something can be measured. The QNX is a Real Time Operating System(RTOS) developed by QSSL(QNX Software Systems Ltd.) in Canada. The ELMSYS is the brand name of commercially available Personal Computer(PC) for applications such as Cabinet Operator Module(COM) of Digital Plant Protection System(DPPS) and COM of Digital Engineered Safety Features Actuation System(DESFAS). The ELMSYS PC Hardware is being qualified by KTL(Korea Testing Lab.) for use as a Cabinet Operator Module(COM). The QNX RTOS is being dedicated by Korea Atomic Energy Research Institute (KAERI). This paper describes the outline and benchmarking test results on Context Switching, Message Passing, Synchronization and Deadline Violation of QNX RTOS under the ELMSYS PC platform

  9. Synthesis of low cycle fatigue test results

    International Nuclear Information System (INIS)

    Andrews, R.M.

    1990-01-01

    Axial strain controlled cycle fatigue tests were carried out on type 316 stainless steel parent metal, vacuum and non-vacuum electron beams welds, submerged arc welds and gas shielded metal arc welds. Testing covered total strains in the range 0.6% to 2%, and was at room temperature and 550 0 C. Parent metal and the electron beam welds showed rapid cyclic hardening, while arc welds showed little hardening. The weld metal cyclic stress-strain response was above that obtained for the parent metal, although below data obtained by other workers for similar parent materials. Weld metal endurances were above the ASME N47 continuous cycling design line at both temperatures, and comparable with parent metal data. However, the weld metal data approached the design line at low strain ranges (around 0.5%). Endurances were predicted from crack growth rates estimated from striation spacings, giving acceptable results except for the gas shielded metal arc weldments. (author)

  10. Results from the STAR TPC system test

    International Nuclear Information System (INIS)

    Betts, W.

    1996-01-01

    A system test of various components of the Solenoidal Tracker at RHIC (STAR) detector, operating in concern, has recently come on-line. Communication between a major sub-detector, a sector of the Time Projection Chamber (TPC), and the trigger, data acquisition and slow controls systems has been established, enabling data from cosmic ray muons to be collected. First results from an analysis of the TPC data are presented. These include measurements of system noise, electronic parameters such as amplifier gains and pedestal values, and tracking resolution for cosmic ray muons and laser induced ionization tracks. A discussion on the experience gained in integrating the different components for the system test is also given

  11. Evaluation of ring tensile test results

    International Nuclear Information System (INIS)

    Chatterjee, S.; Anantharaman, S.; Balakrishnan, K.S.; Sivaramakrish, K.S.

    1990-01-01

    Ring specimens of 5-mm width cut from Zircaloy-2 cladding of reactor operated fuel elements that had experienced 5000 to 15,000 MWD/T of fuel burnup were subjected to ring tensile testing. The true stress-true strain data points up to the onset of necking from the individual load-elongation curves of these specimens were used as input data in Voce's equation. The results reveal that the uniform elongation (UE) values generated using Voce's equation were within (UE-2)% of the experimental percent uniform elongation (UE%). The corresponding ultimate tensile strength values were within ±1%. The uncertainty inherently associated in the determination of gauge length introduces extraneous deformation in the rings tested. Previous results had shown that a 14% increase in cladding diameter caused the gauge length to increase by 40%. To simulate the contribution of extraneous deformation due to an increase in cladding diameter, an analysis of the variation of the tensile parameters (uniform elongation and ultimate tensile strength) due to increase in the gauge length in the range of 10 to 40% was carried out. The results are discussed

  12. Dual color radiometer imagery and test results

    International Nuclear Information System (INIS)

    Silver, A.; Carlen, F.; Link, D.; Zegel, F.

    1989-01-01

    This paper presents a review of the technical characteristics of the Dual Color Radiometer and recent data and test results. The Dual Color Radiometer is a state-of-the-art device that provides simultaneous pixel to pixel registered thermal imagery in both the 3 to 5 and 8 to 12 micron regions. The device is unique in terms of its spatial and temperature resolution of less than 0.10 degrees C temperature and 0.10 milliradian spatial resolution. In addition, the device is tailored for use by the Automatic Target Recognizer (ATR) community

  13. Review fantastic medical implications of 3D-printing in liver surgeries, liver regeneration, liver transplantation and drug hepatotoxicity testing: A review.

    Science.gov (United States)

    Wang, Jing-Zhang; Xiong, Nan-Yan; Zhao, Li-Zhen; Hu, Jin-Tian; Kong, De-Cheng; Yuan, Jiang-Yong

    2018-06-07

    The epidemiological trend in liver diseases becomes more serious worldwide. Several recent articles published by International Journal of Surgery in 2018 particularly emphasized the encouraging clinical benefits of hepatectomy, liver regeneration and liver transplantation, however, there are still many technical bottlenecks underlying these therapeutic approaches. Remarkably, a few preliminary studies have shown some clues to the role of three-dimensional (3D) printing in improving traditional therapy for liver diseases. Here, we concisely elucidated the curative applications of 3D-printing (no cells) and 3D Bio-printing (with hepatic cells), such as 3D-printed patient-specific liver models and devices for medical education, surgical simulation, hepatectomy and liver transplantation, 3D Bio-printed hepatic constructs for liver regeneration and artificial liver, 3D-printed liver tissues for evaluating drug's hepatotoxicity, and so on. Briefly, 3D-printed liver models and bioactive tissues may facilitate a lot of key steps to cure liver disorders, predictably bringing promising clinical benefits. This work further provides novel insights into facilitating treatment of hepatic carcinoma, promoting liver regeneration both in vivo and in vitro, expanding transplantable liver resources, maximizing therapeutic efficacy as well as minimizing surgical complications, medical hepatotoxicity, operational time, economic costs, etc. Copyright © 2018. Published by Elsevier Ltd.

  14. Arc melter demonstration baseline test results

    International Nuclear Information System (INIS)

    Soelberg, N.R.; Chambers, A.G.; Anderson, G.L.; Oden, L.L.; O'Connor, W.K.; Turner, P.C.

    1994-07-01

    This report describes the test results and evaluation for the Phase 1 (baseline) arc melter vitrification test series conducted for the Buried Waste Integrated Demonstration program (BWID). Phase 1 tests were conducted on surrogate mixtures of as-incinerated wastes and soil. Some buried wastes, soils, and stored wastes at the INEL and other DOE sites, are contaminated with transuranic (TRU) radionuclides and hazardous organics and metals. The high temperature environment in an electric arc furnace may be used to process these wastes to produce materials suitable for final disposal. An electric arc furnace system can treat heterogeneous wastes and contaminated soils by (a) dissolving and retaining TRU elements and selected toxic metals as oxides in the slag phase, (b) destroying organic materials by dissociation, pyrolyzation, and combustion, and (c) capturing separated volatilized metals in the offgas system for further treatment. Structural metals in the waste may be melted and tapped separately for recycle or disposal, or these metals may be oxidized and dissolved into the slag. The molten slag, after cooling, will provide a glass/ceramic final waste form that is homogeneous, highly nonleachable, and extremely durable. These features make this waste form suitable for immobilization of TRU radionuclides and toxic metals for geologic timeframes. Further, the volume of contaminated wastes and soils will be substantially reduced in the process

  15. AOF: standalone test results of GALACSI

    Science.gov (United States)

    La Penna, P.; Aller Carpentier, E.; Argomedo, J.; Arsenault, R.; Conzelmann, R. D.; Delabre, B.; Donaldson, R.; Gago, F.; Gutierrez-Cheetam, P.; Hubin, N.; Jolley, P.; Kiekebusch, M.; Kirchbauer, J. P.; Klein, B.; Kolb, J.; Kuntschner, H.; Le Louarn, M.; Lizon, J.-L.; Madec, P.-Y.; Manescau, A.; Mehrgan, L.; Oberti, S.; Quentin, J.; Sedghi, B.; Ströbele, S.; Suárez Valles, M.; Soenke, C.; Tordo, S.; Vernet, J.

    2016-07-01

    GALACSI is the Adaptive Optics (AO) module that will serve the MUSE Integral Field Spectrograph. In Wide Field Mode it will enhance the collected energy in a 0.2"×0.2" pixel by a factor 2 at 750 nm over a Field of View (FoV) of 1'×1' using the Ground Layer AO (GLAO) technique. In Narrow Field Mode, it will provide a Strehl Ratio of 5% (goal 10%) at 650 nm, but in a smaller FoV (7.5"×7.5" FoV), using Laser Tomography AO (LTAO). Before being ready for shipping to Paranal, the system has gone through an extensive testing phase in Europe, first in standalone mode and then in closed loop with the DSM in Europe. After outlining the technical features of the system, we describe here the first part of that testing phase and the integration with the AOF ASSIST (Adaptive Secondary Setup and Instrument Stimulator) testbench, including a specific adapter for the IRLOS truth sensor. The procedures for the standalone verification of the main system performances are outlined, and the results of the internal functional tests of GALACSI after full integration and alignment on ASSIST are presented.

  16. Partial-array test results in IFSMTF

    International Nuclear Information System (INIS)

    Lue, J.W.; Dresner, L.; Koizumi, K.; Lubell, M.S.; Luton, J.N.; Shen, S.S.; Zahn, G.R.; Zichy, J.A.

    1985-01-01

    Preliminary performance tests of two large superconducting magnets have been carried out in the International Fusion Superconducting Magnet Test Facility (IFSMTF). Each of the Japanese (JA) and General Dynamics/Convair (GD) coils was operated up to its full design current of 10.2 kA with the other serving as an adjacent background coil at 40% of design current. Cryostatic stability was demonstrated for both coils by noting recovery from a full half-turn (5 m) driven normal. A new pick-up coil compensation scheme was successfully used for the quench detection system. Each coil remained superconducting when the other was dumped. Unique instrumentation was used to measure changes in bore dimensions and displacement of the winding from the coil case. Agreement between structural analysis and measurement of bore dimension changes resulting from magnetic loads is good. The Swiss (CH) coil underwent only a cryogenic test. The forced cooling worked well and an inlet temperature of 3.8 K was demonstrated

  17. Percutaneous angioplasty of portal vein stenosis that complicated liver transplantation: the mid-term therapeutic results

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kwang Bo; Choo, Sung Wook; Do, Young Soo; Shin, Sung Wook; Cho, Sung Gi; Choo, In Wook [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2005-09-15

    We wanted to valuate the mid-term therapeutic results of percutaneous transhepatic balloon angioplasty for portal vein stenosis after liver transplantation. From May 1996 to Feb 2005, 420 patients underwent liver transplantation. Percutaneous transhepatic angioplasty of the portal vein was attempted in six patients. The patients presented with the clinical signs and symptoms of portal venous hypertension or they were identified by surveillance doppler ultrasonography. The preangioplasty and postangioplasty pressure gradients were recorded. The therapeutic results were monitored by the follow up of the clinical symptoms, the laboratory values, CT and ultrasonography. The overall technical success rate was 100%. The clinical success rate was 83% (5/6). A total of eight sessions of balloon angioplasty were performed in six patients. The mean pressure gradient decreased from 14.5 mmHg to 2.8 mmHg before and after treatment, respectively. The follow up periods ranged from three months to 64 months (mean period; 32 months). Portal venous patency was maintained in all six patients until the final follow up. Combined hepatic venous stenosis was seen in one patient who was treated with stent placement. One patient showed puncture tract bleeding, and this patient was treated with coil embolization of the right portal puncture tract via the left transhepatic portal venous approach. Percutaneous transhepatic balloon angioplasty is an effective treatment for the portal vein stenosis that occurs after liver transplantation, and our results showed good mid-term patency with using this technique.

  18. Updated Results of Ultrasonic Transducer Irradiation Test

    Energy Technology Data Exchange (ETDEWEB)

    Daw, Joshua; Palmer, Joe [Idaho National Laboratory, P.O. Box 1625, MS 4112, Idaho Falls, ID, 38415-3840 (United States); Ramuhalli, Pradeep; Keller, Paul; Montgomery, Robert [Pacific Northwest National Laboratory, 902 Battelle Blvd. Richland, WA, 99354 (United States); Chien, Hual-Te [Argonne National Laboratory, 9700 S. Cass Avenue Argonne, IL, 60439 (United States); Tittmann, Bernhard; Reinhardt, Brian [Pennsylvania State University, 212 Earth and Engr. Sciences Building, University Park, PA, 16802 (United States); Kohse, Gordon [Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139 (United States); Rempe, Joy [Rempe and Associates, LLC, 360 Stillwater, Idaho Falls, ID 83404 (United States); Villard, J.F. [Commissariat a l' energie atomique et aux energies alternatives, Centre d' etudes de Cadarache, 13108 Saint-Paul-lez-Durance (France)

    2015-07-01

    Ultrasonic technologies offer the potential for high accuracy and resolution in-pile measurement of a range of parameters, including geometry changes, temperature, crack initiation and growth, gas pressure and composition, and microstructural changes. Many Department of Energy-Office of Nuclear Energy (DOE-NE) programs are exploring the use of ultrasonic technologies to provide enhanced sensors for in-pile instrumentation during irradiation testing. For example, the ability of small diameter ultrasonic thermometers (UTs) to provide a temperature profile in candidate metallic and oxide fuel would provide much needed data for validating new fuel performance models. These efforts are limited by the lack of identified ultrasonic transducer materials capable of long term performance under irradiation test conditions. To address this need, the Pennsylvania State University (PSU) was awarded an Advanced Test Reactor National Scientific User Facility (ATR NSUF) project to evaluate the performance of promising magnetostrictive and piezoelectric transducers in the Massachusetts Institute of Technology Research Reactor (MITR) up to a fast fluence of at least 10{sup 21} n/cm{sup 2}. A multi-National Laboratory collaboration funded by the Nuclear Energy Enabling Technologies Advanced Sensors and Instrumentation (NEET-ASI) program also provided initial support for this effort. This irradiation, which started in February 2014, is an instrumented lead test and real-time transducer performance data are collected along with temperature and neutron and gamma flux data. The irradiation is ongoing and will continue to approximately mid-2015. To date, very encouraging results have been attained as several transducers continue to operate under irradiation. (authors)

  19. CT portography in the presence of liver steatosis. Potential for a false-negative result

    International Nuclear Information System (INIS)

    Steiner, W.; Scheidler, J.; Kohz, P.; Staebler, A.; Reiser, M.

    1994-01-01

    CT portography is the most sensitive technique currently available for the preoperative diagnosis of liver metastases. We report on a patient with liver steatosis in whom ultrasound examination revealed two liver metastases in the follow up after resection of a papillary carcinoma. The liver metastases could be clearly identified both on plain CT and on enhanced CT with dynamic bolus contrast medium injection. Because of the small difference in attenuation values between liver parenchyma and metastases the two liver metastases had not been recognized on CT portography. When severe and diffuse liver steatosis is present CT portography may fail to detect metastases or small hepatocellular carcinoma. (orig.)

  20. A Study on the Significance of the Colloidal Radiogold Disappearance Rate as a Simple Clinical Liver Function Test

    International Nuclear Information System (INIS)

    Hong, Chang Gi

    1969-01-01

    Liver function in diffuse parenchymal liver such as cirrhosis of the liver depend largely on the effective hepatic blood flow rather than on the individual cell functions. Clinical methods of measuring the hepatic blood flow were developed recently by the application of colloidal disappearance rate. In order to correlate the radiogold disappearance rate to conventional biochemical liver function tests, 21 normal subjects and 80 cases of cirrhosis of the liver were studied with both methods. The results are summarized as following: 1) The validity of external counting method to measure the blood disappearance rate of colloidal radiogold was confirmed by in vitro counting of the serial blood samples. 2) The blood disappearance rate of colloidal radiogold was essentially the same as the liver uptake rate of colloidal radiogold in normal and cirrhotic subjects with various degrees of functional disturbance. And it seemed there was no serious extrahepatic removal of the colloidal radiogold. 3) The disappearance rate of colloidal radiogold was not significant changed by the posture change, but was enhanced by ingestion of 500 ml of water. 4) The disappearance rate of colloidal radiogold was not influenced y single dose of Telepaque, while BSP retention was increased after Telepaque. 5) The mean disappearance half time of colloidal radiogold in normal subjects was 2.49±0.391 (S.D.) minutes. The mean normal disappearance rate constant (K value) was 0.285±0.0428 (S.D.)/minute. 6) The colloidal radiogold disappearance half time was abnormally prolonged (over 3.2 mm) in 87.7±3.68 (S.D.) % of cirrhotic subjects. 7) In patients of liver cirrhosis the blood disappearance rate of colloidal radiogold correlated well to serum albumin and globulin levels and BSP retention which were considered to reflect functions of hepatic parenchymal cells. There was, however, no correlation between colloidal disappearance rate and thymol turbidity test, serum glutamic pyruvic transaminase

  1. Cyberknife Stereotactic Body Radiation Therapy for Nonresectable Tumors of the Liver: Preliminary Results

    Directory of Open Access Journals (Sweden)

    K. Goyal

    2010-01-01

    Full Text Available Purpose. Stereotactic body radiation therapy (SBRT has emerged as a treatment option for local tumor control of primary and secondary malignancies of the liver. We report on our updated experience with SBRT in patients with non-resectable tumors of the liver. Methods. Our first 17 consecutive patients (mean age 58.1 years receiving SBRT for HCC (=6, IHC (=3, and LM (=8 are presented. Mean radiation dose was 34Gy delivered over 1–3 fractions. Results. Treated patients had a mean decrease in maximum pretreatment tumor diameter from 6.9±4.6 cm to 5.0±2.1 cm at three months after treatment (<.05. The mean total tumor volume reduction was 44% at six months (<.05. 82% of all patients (14/17 achieved local control with a median follow-up of 8 months. 100% of patients with HCC (=6 achieved local control. Patients with surgically placed fiducial markers had no complications related to marker placement. Conclusion. Our preliminary results showed that SBRT is a safe and effective local treatment modality in selected patients with liver malignancies with minimal adverse events. Further studies are needed to define its role in the management of these malignancies.

  2. Results from the Cooler and Lead Tests

    International Nuclear Information System (INIS)

    Green, Michael A.

    2010-01-01

    The report presents the results of testing MICE spectrometer magnet current leads on a test apparatus that combines both the copper leads and the high temperature superconducting (HTS) leads with a single Cryomech PT415 cooler and liquid helium tank. The current is carried through the copper leads from 300 K to the top of the HTS leads. The current is then carried through the HTS leads to a feed-through from the vacuum space to the inside of a liquid helium tank. The experiment allows one to measure the performance of both cooler stages along with the performance of the leads. While the leads were powered we measured the voltage drops through the copper leads, through the HTS leads, through spliced to the feed-through, through the feed-through and through the low-temperature superconducting loop that connects one lead to the other. Measurements were made using the leads that were used in spectrometer magnet 1A and spectrometer magnet 2A. These are the same leads that were used for Superbend and Venus magnets at LBNL. The IL/A for these leads was 5.2 x 10 6 m -1 . The leads turned out to be too long. The same measurements were made using the leads that were installed in magnet 2B. The magnet 2B leads had an IL/A of 3.3 x 10 6 A m -1 . This report discusses the cooler performance and the measured electrical performance of the lead circuit that contains the copper leads and the superconducting leads. All of the HTS leads that were installed in magnet 2B were current tested using this apparatus.

  3. Should we look for celiac disease among all patients with liver function test abnormalities?

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Emami

    2012-01-01

    Full Text Available Background: Celiac disease (CD has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (LFT. As there is no precise data from our country in this regard, we investigated the prevalence of CD in patients presenting with abnormal LFT. Methods: From 2003 to 2008, we measured IgA anti-tissue transglutaminase (t-TG antibody (with ELISA technique within the first-level screening steps for all patients presenting with abnormal LFT to three outpatient gastroenterology clinics in Isfahan, IRAN. All subjects with an IgA anti-tTG antibody value of >10 μ/ml (seropositive were undergone upper gastrointestinal endoscopy and duodenal biopsy. Histopathological changes were assessed according to the Marsh classification. CD was defined as being seropositive with Marsh I or above in histopathology and having a good response to gluten free diet (GFD. Results: During the study, 224 patients were evaluated, out of which, 10 patients (4.4% were seropositive for CD. Duodenal biopsies were performed in eight patients and revealed six (2.7% cases of Marsh I or above (four Marsh IIIA, two Marsh I, all of them had good response to GFD. The overall prevalence of CD among patients with hypertransaminasemia, autoimmune hepatitis, and cryptogenic cirrhosis was determined as 10.7% (3/28, 3.4% (2/59, and 5.3% (1/19, respectively. Conclusion: Serological screening with IgA anti-tTG antibody test should be routinely performed in patients presenting with abnormal LFT and especially those with chronic liver diseases including hypertransaminasemia, autoimmune hepatitis, and cryptogenic cirrhosis.

  4. Preliminary results of 'liver-first' reverse management for advanced and aggressive synchronous colorectal liver metastases: a propensity-matched analysis.

    Science.gov (United States)

    Tanaka, Kuniya; Murakami, Takashi; Matsuo, Kenichi; Hiroshima, Yukihiko; Endo, Itaru; Ichikawa, Yasushi; Taguri, Masataka; Koda, Keiji

    2015-01-01

    Although a 'liver-first' approach recently has been advocated in treating synchronous colorectal metastases, little is known about how results compare with those of the classical approach among patients with similar grades of liver metastases. Propensity-score matching was used to select study subjects. Oncologic outcomes were compared between 10 consecutive patients with unresectable advanced and aggressive synchronous colorectal liver metastases treated with the reverse strategy and 30 comparable classically treated patients. Numbers of recurrence sites and recurrent tumors irrespective of recurrence sites were greater in the reverse group then the classic group (p = 0.003 and p = 0.015, respectively). Rates of freedom from recurrence in the remaining liver and of freedom from disease also were poorer in the reverse group than in the classical group (p = 0.009 and p = 0.043, respectively). Among patients treated with 2-stage hepatectomy, frequency of microvascular invasion surrounding macroscopic metastases at second resection was higher in the reverse group than in the classical group (p = 0.011). Reverse approaches may be feasible in treating synchronous liver metastases, but that strategy should be limited to patients with less liver tumor burden. © 2015 S. Karger AG, Basel.

  5. Tuned Chamber Core Panel Acoustic Test Results

    Science.gov (United States)

    Schiller, Noah H.; Allen, Albert R.

    2016-01-01

    This report documents acoustic testing of tuned chamber core panels, which can be used to supplement the low-frequency performance of conventional acoustic treatment. The tuned chamber core concept incorporates low-frequency noise control directly within the primary structure and is applicable to sandwich constructions with a directional core, including corrugated-, truss-, and fluted-core designs. These types of sandwich structures have long, hollow channels (or chambers) in the core. By adding small holes through one of the facesheets, the hollow chambers can be utilized as an array of low-frequency acoustic resonators. These resonators can then be used to attenuate low-frequency noise (below 400 Hz) inside a vehicle compartment without increasing the weight or size of the structure. The results of this test program demonstrate that the tuned chamber core concept is effective when used in isolation or combined with acoustic foam treatments. Specifically, an array of acoustic resonators integrated within the core of the panels was shown to improve both the low-frequency absorption and transmission loss of the structure in targeted one-third octave bands.

  6. Liver function tests and risk prediction of incident type 2 diabetes : evaluation in two independent cohorts

    NARCIS (Netherlands)

    Abbasi, Ali; Bakker, Stephan J. L.; Corpeleijn, Eva; van der A, Daphne L.; Gansevoort, Ron T.; Gans, Rijk O. B.; Peelen, Linda M.; van der Schouw, Yvonne T.; Stolk, Ronald P.; Navis, Gerjan; Spijkerman, Annemieke M. W.; Beulens, Joline W. J.

    2012-01-01

    Background: Liver function tests might predict the risk of type 2 diabetes. An independent study evaluating utility of these markers compared with an existing prediction model is yet lacking. Methods and Findings: We performed a case-cohort study, including random subcohort (6.5%) from 38,379

  7. "CONGENTIAL PANHYPOPITUITARISM ASSOCIATED WITH IMPAIRED LIVER FUNCTION TESTS AND CONGENITAL HEART DISEASE"

    Directory of Open Access Journals (Sweden)

    Z. Khalili-Matinzadeh

    2006-06-01

    Full Text Available The term congenital hypopituitarism defines deficiency of all of the pituitary hormones. Hypoglycemia and microphallus (in males are common findings, and some infants have shown evidence of the neonatal hepatitis syndrome. We report a case of congenital panhypopituitarism with deficiency of six major hormones and association with severe hypoglycemia, impaired liver function tests and congenital heart disease.

  8. Field Lysimeter Test Facility: Second year (FY 1989) test results

    International Nuclear Information System (INIS)

    Campbell, M.D.; Gee, G.W.; Kanyid, M.J.; Rockhold, M.L.

    1990-04-01

    The Record of Decision associated with the Hanford Defense Waste Environmental Impact Statement (53 FR 12449-53) commits to an evaluation of the use of protective barriers placed over near-surface wastes. The barrier must protect against wind and water erosion and limit plant and animal intrusion and infiltration of water. Successful conclusion of this program will yield the necessary protective barrier design for near-surface waste isolation. This report presents results from the second year of tests at the FLTF. The primary objective of testing protective barriers at the FLTF was to measure the water budgets within the various barriers and assess the effectiveness of their designs in limiting water intrusion into the zone beneath each barrier. Information obtained from these measurements is intended for use in refining barrier designs. Four elements of water budget were measured during the year: precipitation, evaporation, storage, and drainage. Run-off, which is a fifth element of a complete water budget, was made negligible by a lip on the lysimeters that protrudes 5 cm above the soil surface to prevent run-off. A secondary objective of testing protective barriers at the FLTF was to refine procedures and equipment to support data collection for verification of the computer model needed for long-term projections of barrier performance. 6 refs

  9. A prototype tap test imaging system: Initial field test results

    Science.gov (United States)

    Peters, J. J.; Barnard, D. J.; Hudelson, N. A.; Simpson, T. S.; Hsu, D. K.

    2000-05-01

    This paper describes a simple, field-worthy tap test imaging system that gives quantitative information about the size, shape, and severity of defects and damages. The system consists of an accelerometer, electronic circuits for conditioning the signal and measuring the impact duration, a laptop PC and data acquisition and processing software. The images are generated manually by tapping on a grid printed on a plastic sheet laid over the part's surface. A mechanized scanner is currently under development. The prototype has produced images for a variety of aircraft composite and metal honeycomb structures containing flaws, damages, and repairs. Images of the local contact stiffness, deduced from the impact duration using a spring model, revealed quantitatively the stiffness reduction due to flaws and damages, as well as the stiffness enhancement due to substructures. The system has been field tested on commercial and military aircraft as well as rotor blades and engine decks on helicopters. Field test results will be shown and the operation of the system will be demonstrated.—This material is based upon work supported by the Federal Aviation Administration under Contract #DTFA03-98-D-00008, Delivery Order No. IA016 and performed at Iowa State University's Center for NDE as part of the Center for Aviation Systems Reliability program.

  10. Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.

    Science.gov (United States)

    Boursier, Jérôme; Bertrais, Sandrine; Oberti, Frédéric; Gallois, Yves; Fouchard-Hubert, Isabelle; Rousselet, Marie-Christine; Zarski, Jean-Pierre; Calès, Paul

    2011-11-30

    Non-invasive tests have been constructed and evaluated mainly for binary diagnoses such as significant fibrosis. Recently, detailed fibrosis classifications for several non-invasive tests have been developed, but their accuracy has not been thoroughly evaluated in comparison to liver biopsy, especially in clinical practice and for Fibroscan. Therefore, the main aim of the present study was to evaluate the accuracy of detailed fibrosis classifications available for non-invasive tests and liver biopsy. The secondary aim was to validate these accuracies in independent populations. Four HCV populations provided 2,068 patients with liver biopsy, four different pathologist skill-levels and non-invasive tests. Results were expressed as percentages of correctly classified patients. In population #1 including 205 patients and comparing liver biopsy (reference: consensus reading by two experts) and blood tests, Metavir fibrosis (FM) stage accuracy was 64.4% in local pathologists vs. 82.2% (p blood tests, the discrepancy scores, taking into account the error magnitude, of detailed fibrosis classification were significantly different between FibroMeter2G (0.30 ± 0.55) and FibroMeter3G (0.14 ± 0.37, p blood tests and Fibroscan, accuracies of detailed fibrosis classification were, respectively: Fibrotest: 42.5% (33.5%), Fibroscan: 64.9% (50.7%), FibroMeter2G: 68.7% (68.2%), FibroMeter3G: 77.1% (83.4%), p fibrosis classification of the best-performing blood test outperforms liver biopsy read by a local pathologist, i.e., in clinical practice; however, the classification precision is apparently lesser. This detailed classification accuracy is much lower than that of significant fibrosis with Fibroscan and even Fibrotest but higher with FibroMeter3G. FibroMeter classification accuracy was significantly higher than those of other non-invasive tests. Finally, for hepatitis C evaluation in clinical practice, fibrosis degree can be evaluated using an accurate blood test.

  11. Predicting visual semantic descriptive terms from radiological image data: preliminary results with liver lesions in CT.

    Science.gov (United States)

    Depeursinge, Adrien; Kurtz, Camille; Beaulieu, Christopher; Napel, Sandy; Rubin, Daniel

    2014-08-01

    We describe a framework to model visual semantics of liver lesions in CT images in order to predict the visual semantic terms (VST) reported by radiologists in describing these lesions. Computational models of VST are learned from image data using linear combinations of high-order steerable Riesz wavelets and support vector machines (SVM). In a first step, these models are used to predict the presence of each semantic term that describes liver lesions. In a second step, the distances between all VST models are calculated to establish a nonhierarchical computationally-derived ontology of VST containing inter-term synonymy and complementarity. A preliminary evaluation of the proposed framework was carried out using 74 liver lesions annotated with a set of 18 VSTs from the RadLex ontology. A leave-one-patient-out cross-validation resulted in an average area under the ROC curve of 0.853 for predicting the presence of each VST. The proposed framework is expected to foster human-computer synergies for the interpretation of radiological images while using rotation-covariant computational models of VSTs to 1) quantify their local likelihood and 2) explicitly link them with pixel-based image content in the context of a given imaging domain.

  12. Hepatic (Liver) Function Panel

    Science.gov (United States)

    ... Educators Search English Español Blood Test: Hepatic (Liver) Function Panel KidsHealth / For Parents / Blood Test: Hepatic (Liver) ... kidneys ) is working. What Is a Hepatic (Liver) Function Panel? A liver function panel is a blood ...

  13. Microwave ablation: Results with double 915 MHz antennae in ex vivo bovine Livers

    International Nuclear Information System (INIS)

    Shi Wenyuan; Liang Ping; Zhu Qiang; Yu Xiaoling; Shao Qiujie; Lu Tong; Wang Yang; Dong Baowei

    2011-01-01

    Purpose: To investigate the settings for the optimal microwave ablation geometry with the simultaneous application of double 915 MHz antennae in ex vivo bovine livers, so as to provide the technical basis for treating large liver tumor in one ablation session. Materials and methods: MWAs were performed on ex vivo bovine livers by simultaneously application of double 915 MHz internally cooled-shaft antennae. Four power settings (50, 60, 70 and 80 W) were used during MWAs, while application time was fixed at 10 min. Three inter-antenna distances (2.0, 2.5 and 3.0 cm) were used. Diameters and shapes of the coagulation zones were observed on gross specimens. Results: (1) The coagulation shape was related to the inter-antenna distance, which was most spherical at an inter-antenna distance of 2.0 cm. A recess of the coagulation zone was observed at an inter-antenna distances of 2.5 and 3.0 cm. (2) The long-axis and short-axis coagulation diameter enlarged with increasing power output. However, there were no significant differences in the coagulation diameters between 70 and 80 W (P > 0.05). More desirable coagulation geometry could be obtained by simultaneous application of double antennae at 70 W for 10 min with an inter-antenna distance of 2.0 cm, the long-axis and short-axis coagulation diameter were 6.95 ± 0.32 cm and 5.30 ± 0.22 cm, respectively. Conclusion: Simultaneous application of double 915 MHz antennae can generate large coagulation zones with desirable shape which may be advantageous for treating large liver tumor in one ablation session.

  14. Full length prototype SSC dipole test results

    International Nuclear Information System (INIS)

    Strait, J.; Brown, B.C.; Carson, J.

    1987-01-01

    Results are presented from tests of the first full length prototype SSC dipole magnet. The cryogenic behavior of the magnet during a slow cooldown to 4.5K and a slow warmup to room temperature has been measured. Magnetic field quality was measured at currents up to 2000 A. Averaged over the body field all harmonics with the exception of b 2 and b 8 are at or within the tolerances specified by the SSC Central Design Group. (The values of b 2 and b 8 result from known design and construction defects which will be be corrected in later magnets.) Using an NMR probe the average body field strength is measured to be 10.283 G/A with point to point variations on the order of one part in 1000. Data are presented on quench behavior of the magnet up to 3500 A (approximately 55% of full field) including longitudinal and transverse velocities for the first 250 msec of the quench

  15. The utility of liver function tests for mortality prediction within one year in primary care using the algorithm for liver function investigations (ALFI.

    Directory of Open Access Journals (Sweden)

    David J McLernon

    Full Text Available BACKGROUND: Although liver function tests (LFTs are routinely measured in primary care, raised levels in patients with no obvious liver disease may trigger a range of subsequent expensive and unnecessary management plans. The aim of this study was to develop and validate a prediction model to guide decision-making by general practitioners, which estimates risk of one year all-cause mortality in patients with no obvious liver disease. METHODS: In this population-based historical cohort study, biochemistry data from patients in Tayside, Scotland, with LFTs performed in primary care were record-linked to secondary care and prescription databases to ascertain baseline characteristics, and to mortality data. Using this derivation cohort a survival model was developed to predict mortality. The model was assessed for calibration, discrimination (using the C-statistic and performance, and validated using a separate cohort of Scottish primary care practices. RESULTS: From the derivation cohort (n = 95 977, 2.7% died within one year. Predictors of mortality included: age; male gender; social deprivation; history of cancer, renal disease, stroke, ischaemic heart disease or respiratory disease; statin use; and LFTs (albumin, transaminase, alkaline phosphatase, bilirubin, and gamma-glutamyltransferase. The C-statistic for the final model was 0.82 (95% CI 0.80-0.84, and was similar in the validation cohort (n = 11 653 0.86 (0.79-0.90. As an example of performance, for a 10% predicted probability cut-off, sensitivity = 52.8%, specificity = 94.0%, PPV = 21.0%, NPV = 98.5%. For the model without LFTs the respective values were 43.8%, 92.8%, 15.6%, 98.1%. CONCLUSIONS: The Algorithm for Liver Function Investigations (ALFI is the first model to successfully estimate the probability of all-cause mortality in patients with no apparent liver disease having LFTs in primary care. While LFTs added to the model's discrimination and sensitivity, the

  16. Summary of CPAS EDU Testing Analysis Results

    Science.gov (United States)

    Romero, Leah M.; Bledsoe, Kristin J.; Davidson, John.; Engert, Meagan E.; Fraire, Usbaldo, Jr.; Galaviz, Fernando S.; Galvin, Patrick J.; Ray, Eric S.; Varela, Jose

    2015-01-01

    The Orion program's Capsule Parachute Assembly System (CPAS) project is currently conducting its third generation of testing, the Engineering Development Unit (EDU) series. This series utilizes two test articles, a dart-shaped Parachute Compartment Drop Test Vehicle (PCDTV) and capsule-shaped Parachute Test Vehicle (PTV), both of which include a full size, flight-like parachute system and require a pallet delivery system for aircraft extraction. To date, 15 tests have been completed, including six with PCDTVs and nine with PTVs. Two of the PTV tests included the Forward Bay Cover (FBC) provided by Lockheed Martin. Advancements in modeling techniques applicable to parachute fly-out, vehicle rate of descent, torque, and load train, also occurred during the EDU testing series. An upgrade from a composite to an independent parachute simulation allowed parachute modeling at a higher level of fidelity than during previous generations. The complexity of separating the test vehicles from their pallet delivery systems necessitated the use the Automatic Dynamic Analysis of Mechanical Systems (ADAMS) simulator for modeling mated vehicle aircraft extraction and separation. This paper gives an overview of each EDU test and summarizes the development of CPAS analysis tools and techniques during EDU testing.

  17. Accuracy of liver function tests for predicting adverse maternal and fetal outcomes in women with preeclampsia: a systematic review

    NARCIS (Netherlands)

    Thangaratinam, Shakila; Koopmans, Corine M.; Iyengar, Shalini; Zamora, Javier; Ismail, Khaled M. K.; Mol, Ben W. J.; Khan, Khalid S.

    2011-01-01

    Background. Liver function tests are routinely performed in women as part of a battery of investigations to assess severity at admission and later to guide appropriate management. Objective. To determine the accuracy with which liver function tests predict complications in women with preeclampsia by

  18. Accuracy of liver function tests for predicting adverse maternal and fetal outcomes in women with preeclampsia : a systematic review

    NARCIS (Netherlands)

    Thangaratinam, Shakila; Koopmans, Corine M.; Iyengar, Shalini; Zamora, Javier; Ismail, Khaled M. K.; Mol, Ben W. J.; Khan, Khalid S.

    Background. Liver function tests are routinely performed in women as part of a battery of investigations to assess severity at admission and later to guide appropriate management. Objective. To determine the accuracy with which liver function tests predict complications in women with preeclampsia by

  19. Transjugular intrahepatic portosystemic shunt: results and prognostic factors in patients with post-necrotic liver cirrhosis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jae Hyung; Chung, Jin Wook; Han, Joon Koo; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Yong Joo [Kyungbook National University College of Medicine, Taegu (Korea, Republic of)

    1997-01-01

    To evaluate the effectiveness of transjugular intrahepatic portosystemic shunt(TIPS) in the management of gastroesophageal variceal bleeding and predictive factors for long-term survival in patients with post-necrotic liver cirrhosis. A total of 49 patients with post-necrotic liver cirrhosis underwent TIPS over a recent three-year period. Forty-five had a history of hepatitis B viral infection, and four, of hepatitis C viral infection. In all patients, the indication for the procedure was variceal bleeding. Child-Pugh class was A in seven patients, B in 16 and C in 26 patients at the time of the last bleeding. The effectiveness of portal decompression and bleeding control was evaluated. Long-term survival was calculated by the Kaplan-Meier method and predictive factors were analyzed using the Wilcoxon test. The procedure was technically successful in all cases. The portosystemic pressure gradient decreased significantly from 21.4 {+-} 6.4 mmHg to 12.0 {+-} 5.1 mmHg(N=45). Active variceal bleeding was controlled in 34 of the 37 emergency patients. The total length of follow-up was from one day to three and a half years(mean : 383 {+-} 357 days). Rebleeding developed in 17 patients (35%). Hepatic encephalopathy, either newly developed or aggravated, occurred in 16 (32.7%). The thirty-day mortality rate was 20.4%, and the one-year survival rate was 63.8%. The significant predictive factors for poor prognosis were Child-Pugh class C and post-TIPS hepatic encephalopathy. TIPS is effective in portal decompression in the patients with variceal bleeding due to post-necrotic liver cirrhosis. The Child-Pugh classification and hepatic encephalopathy after TIPS are considered to be significant predictive factors for long-term survival.

  20. Transjugular intrahepatic portosystemic shunt: results and prognostic factors in patients with post-necrotic liver cirrhosis

    International Nuclear Information System (INIS)

    Park, Jae Hyung; Chung, Jin Wook; Han, Joon Koo; Han, Man Chung; Kim, Yong Joo

    1997-01-01

    To evaluate the effectiveness of transjugular intrahepatic portosystemic shunt(TIPS) in the management of gastroesophageal variceal bleeding and predictive factors for long-term survival in patients with post-necrotic liver cirrhosis. A total of 49 patients with post-necrotic liver cirrhosis underwent TIPS over a recent three-year period. Forty-five had a history of hepatitis B viral infection, and four, of hepatitis C viral infection. In all patients, the indication for the procedure was variceal bleeding. Child-Pugh class was A in seven patients, B in 16 and C in 26 patients at the time of the last bleeding. The effectiveness of portal decompression and bleeding control was evaluated. Long-term survival was calculated by the Kaplan-Meier method and predictive factors were analyzed using the Wilcoxon test. The procedure was technically successful in all cases. The portosystemic pressure gradient decreased significantly from 21.4 ± 6.4 mmHg to 12.0 ± 5.1 mmHg(N=45). Active variceal bleeding was controlled in 34 of the 37 emergency patients. The total length of follow-up was from one day to three and a half years(mean : 383 ± 357 days). Rebleeding developed in 17 patients (35%). Hepatic encephalopathy, either newly developed or aggravated, occurred in 16 (32.7%). The thirty-day mortality rate was 20.4%, and the one-year survival rate was 63.8%. The significant predictive factors for poor prognosis were Child-Pugh class C and post-TIPS hepatic encephalopathy. TIPS is effective in portal decompression in the patients with variceal bleeding due to post-necrotic liver cirrhosis. The Child-Pugh classification and hepatic encephalopathy after TIPS are considered to be significant predictive factors for long-term survival

  1. COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER

    Directory of Open Access Journals (Sweden)

    O.A Gerasimova

    2012-01-01

    Full Text Available Russian Scientist Centre for Radiology and Surgical Technology has sufficient experience of orthotopic liver transplantation (100 OLT, which allowed comparing the outcomes of the terminal stages of liver disease in the two most numerous groups of patients: viral cirrhosis (VH and autoimmune liver diseases (AILD. Despite the fact that patients with VH indicator of urgency performing OLT (MELD lower, rate of deaths on the waiting list higher than AILD, due to more favorable course of immune disease. After OLT significant differences during the early and last posttransplant periods were not found, although the recurrences of viral hepatitis are recorded much more frequently than AILD. One-year and a three-year survival rates were comparable. To prevent reinfection of the hepatitis B successfully used nucleoside analogues (telbivudine, which allowed minimizing recurrence of the disease. Prevention and treatment of hepatitis C after the OLT is a relevant problem, despite the low efficiency of antiviral therapy. Relapses AILD not represent a real threat to the life of the patients, because the modification of immunosuppressive therapy can limit the progression of the disease. 

  2. Initial Burn Pan (JMTF) Testing Results

    Science.gov (United States)

    2016-03-01

    burn pan and one located high on the Ex-USS Shadwell. There were also a number of GoPro cameras (3-4) that were positioned to observe specific...locations around the test area. A remote control drone equipped with a GoPro camera was also used to video the third test. All recorded video and still

  3. Liver fibrosis diagnosis by blood test and elastography in chronic hepatitis C: agreement or combination?

    Science.gov (United States)

    Calès, P; Boursier, J; Lebigot, J; de Ledinghen, V; Aubé, C; Hubert, I; Oberti, F

    2017-04-01

    In chronic hepatitis C, the European Association for the Study of the Liver and the Asociacion Latinoamericana para el Estudio del Higado recommend performing transient elastography plus a blood test to diagnose significant fibrosis; test concordance confirms the diagnosis. To validate this rule and improve it by combining a blood test, FibroMeter (virus second generation, Echosens, Paris, France) and transient elastography (constitutive tests) into a single combined test, as suggested by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America. A total of 1199 patients were included in an exploratory set (HCV, n = 679) or in two validation sets (HCV ± HIV, HBV, n = 520). Accuracy was mainly evaluated by correct diagnosis rate for severe fibrosis (pathological Metavir F ≥ 3, primary outcome) by classical test scores or a fibrosis classification, reflecting Metavir staging, as a function of test concordance. Score accuracy: there were no significant differences between the blood test (75.7%), elastography (79.1%) and the combined test (79.4%) (P = 0.066); the score accuracy of each test was significantly (P tests. Classification accuracy: combined test accuracy (91.7%) was significantly (P blood test (84.1%) and elastography (88.2%); accuracy of each constitutive test was significantly (P tests but not with combined test: 89.0 vs. 92.7% (P = 0.118). Multivariate analysis for accuracy showed an interaction between concordance and fibrosis level: in the 1% of patients with full classification discordance and severe fibrosis, non-invasive tests were unreliable. The advantage of combined test classification was confirmed in the validation sets. The concordance recommendation is validated. A combined test, expressed in classification instead of score, improves this rule and validates the recommendation of a combined test, avoiding 99% of biopsies, and offering precise staging. © 2017 John Wiley & Sons Ltd.

  4. Comparison of blood tests for liver fibrosis specific or not to NAFLD.

    Science.gov (United States)

    Calès, Paul; Lainé, Fabrice; Boursier, Jérôme; Deugnier, Yves; Moal, Valérie; Oberti, Frédéric; Hunault, Gilles; Rousselet, Marie Christine; Hubert, Isabelle; Laafi, Jihane; Ducluzeaux, Pierre Henri; Lunel, Françoise

    2009-01-01

    To compare blood tests of liver fibrosis specific for NAFLD: the FibroMeter NAFLD and the NAFLD fibrosis score (NFSA) with a non-specific test, APRI. Two hundred and thirty-five NAFLD patients with liver Metavir staging and blood markers from two independent centres were randomly assigned to a test (n=121) or a validation population (n=114). The highest accuracy--91%--for significant fibrosis was obtained with the FibroMeter whose (i) AUROC (0.943) was significantly higher than those of NFSA (0.884, p=0.008) and APRI (0.866, pliver biopsy could have been avoided in most patients: FibroMeter: 97.4% vs NFSA: 86.8% (pfibrosis, significantly outperforming NFSA and APRI.

  5. Supercritical CO2 test loop operation and first test results

    International Nuclear Information System (INIS)

    Wright, Steven A.; Pickard, Paul S.

    2009-01-01

    The DOE Office of Nuclear Energy is investigating advanced Brayton cycles for use with next generation nuclear power plants. The focus of this work is on the supercritical CO 2 Brayton cycle which has the potential for high efficiency, and for reduced capital costs due to very compact turbomachinery. Sandia has fabricated and is operating a supercritical CO 2 (S-CO 2 ) test loop to investigate the key technology issues associated with this cycle. This loop is part of a multi-year phased development program to develop a megawatt (MW) class closed S-CO 2 Brayton cycle to demonstrate the applicability of this cycle for DOE Gen-IV program. The current loop has been configured as both a compression loop and as simple heated but unrecuperated Brayton cycle. A second split-flow or re-compression Brayton cycle is currently under development that will use approximately 1 MW of heat to run the Brayton cycle. Early configurations of this split-flow Brayton cycle will be operational later this fiscal year. The key issues for this cycle include the fundamental issues of compressor fluid performance and system control near the critical point, but also the supporting technology issues of bearings, sealing technologies, and rotor windage losses which are also essential to achieving efficiency and cost objectives. These tests are providing the first measurements and information on these key supercritical CO 2 power conversion systems questions. Important data for all these issues has been obtained. This report presents the major results of the testing by showing and comparing the measured compressor performance map with the predicted performance. The compression loop uses a ∼50 kWe motor driven compressor to spin a 37 mm OD compressor at design speeds up to 75,000 rpm with a pressure ratio of 1.8 and a flow rate of 3.53 kg/s for a compressor inlet condition of 305.3 K and 7690 kPa. The most recent configuration of this loop has added a small turbine and 260 kW of heater power is

  6. SCTF Core-I test results

    International Nuclear Information System (INIS)

    Adachi, Hiromichi; Sudo, Yukio; Iwamura, Takamichi; Osakabe, Masahiro; Ohnuki, Akira; Hirano, Kemmei

    1982-07-01

    The Slab Core Test Facility (SCTF) of Japan Atomic Energy Research Institute (JAERI) was constructed to investigate two-dimensional thermohydrodynamics in the core and the communication in fluid behavior between the core and the upper plenum during the last part of blowdown, refill and reflood phases of a posturated loss-of-coolant accident (LOCA) of a pressurized water reactor (PWR). In the present report, effects of system pressure on reflooding phenomena shall be discussed based on the data of Tests S1-SH2, S1-01 and S1-02 which are the parameteris tests for system pressure effects belonging to the SCTF Core-I forced flooding test series. Major items discussed in this report are (1) hydrodynamic behavior in the system, (2) core thermal behavior, (3) core heat transfer and (4) two-dimensional hydrodynamic behavior in the pressure vessel including the core. (author)

  7. Reliability Estimation Based Upon Test Plan Results

    National Research Council Canada - National Science Library

    Read, Robert

    1997-01-01

    The report contains a brief summary of aspects of the Maximus reliability point and interval estimation technique as it has been applied to the reliability of a device whose surveillance tests contain...

  8. Test OPTRAN 1-1 results

    International Nuclear Information System (INIS)

    Martinson, Z.R.

    1982-01-01

    The objective of the OPT 1-1 Test Series was to evaluate the extent of damage and the threshold for failure during simulated BWR anticipated transients. Four power transient tests with progressively higher power levels were performed with preirradiated fuel rods at power ramp rates as high as 550 kW/m per second. Six separately shrouded fuel rods fabricated by the General Electric Co., and preirradiated in the Monticello BWR to burnups of about 5000 to 23,000 MWd/t were tested, four at a time. Four of the fuel rods were of typical GE 8 x 8 design, except for fuel length (0.75 m). Two of the rods included design modifications to improve their PCI-resistant characteristics. A lengthy fuel conditioning preceded the transient testing of the fuel rods

  9. Visual perception skills testing: preliminary results

    CSIR Research Space (South Africa)

    Smith, Andrew C

    2009-02-01

    Full Text Available Good visual perception skills are important in the effective manipulation of Tangible User Interfaces. This paper reports on the application of a test set researchers have developed specifically to quantify the visual perception skills of children...

  10. Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Beom Kyung Kim

    Full Text Available Diagnostic values of FibroTest (FT for hepatic fibrosis have rarely been assessed in Asian chronic hepatitis B (CHB patients. We aimed to validate its diagnostic performances in comparison with liver stiffness (LS.From 2008 to 2010, 194 CHB patients who underwent liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis stage was assessed according to the Batts and Ludwig system.To predict significant fibrosis (F≥2, advanced fibrosis (F≥3, and cirrhosis (F = 4, areas under receiver operating characteristic curves (AUROCs of FT were 0.903, 0.907, and 0.866, comparable to those of LS (0.873, 0.897, and 0.910, respectively. Optimized cutoffs of FT to maximize sum of sensitivity and specificity were 0.32, 0.52, and 0.68 for F≥2, F≥3, and F = 4, while those of LS were 8.8, 10.2, and 14.1 kPa, respectively. According to FT and LS cutoffs, 123 (63.4% and 124 (63.9% patients were correctly classified consistent with histological fibrosis (F1, F2, F3, and F4, respectively. Overall concordance between each fibrosis stage estimated by FT and LS was observed in 111 patients, where 88 were correctly classified with histological results. A combination formula adding LS to FT (LS+FT showed similar AUROC levels (0.885, 0.905, and 0.915, while another multiplying LS by FT (LS×FT showed the best AUROCs (0.941, 0.931, and 0.929 for F≥2, F≥3, and F4, respectively.FT provides good fibrosis prediction, with comparable outcomes to LS in Asian CHB patients. FT substantially reduces need for liver biopsy, especially when used in combination with LS.

  11. Overview of the PBF test results

    International Nuclear Information System (INIS)

    Zeile, H.J.

    1980-01-01

    The Thermal Fuels Behavior Program (TFBP) of EG and G Idaho conducts fuel behavior research in the Power Burst Facility (PBF) at INEL and at the Halden Reactor in Norway. The fuels behavior research in the PBF is directed toward providing a detailed understanding of the response of light water reactor (LWR) nuclear fuel assemblies to off-normal and hypothesized accident conditions. Single fuel rods and clusters of highly instrumented fuel rods are installed within a central test space of the PBF core for testing. The core can be operated in various modes to provide test conditions typical of accidents and off-normal conditions that may be experienced in a pressurized water reactor or a boiling water reactor

  12. Tests results of skutterudite based thermoelectric unicouples

    International Nuclear Information System (INIS)

    Saber, Hamed H.; El-Genk, Mohamed S.; Caillat, Thierry

    2007-01-01

    Tests were performed of skutterudite based unicouples with (MAY-04) and without (MAR-03) metallic coating on the legs near the hot junction to quantify the effect on reducing performance degradation with operation time. The p-legs in the unicouples were made of CeFe 3.5 Co 0.5 Sb 12 and the n-legs of CoSb 3 . The MAY-04 test was performed in vacuum (∼9 x 10 -7 torr) for ∼2000 h at hot and cold junction temperatures of 892.1 ± 11.9 K and 316.1 ± 5.5 K, respectively, while the MAR-03 test was performed in argon cover gas (0.051-0.068 MPa) at 972.61 ± 10.0 K and 301.1 ± 5.1 K, respectively. The argon cover gas decreased antimony loss from the legs in the MAR-03 test, but marked degradation in performance occurred over time. Conversely, the metallic coating in the MAY-04 test was very effective in reducing performance degradation of the unicouple. Because the cross sectional areas of the legs in MAY-04 were larger than those in MAR-03, the measured electrical power of the former is much higher than that of the latter, but the Beginning of Test (BOT) open circuit voltages, V oc (204.2 mV) for both unicouples were almost the same. The peak electrical power of the MAY-04 unicouple decreased 12.35% from 1.62W e at BOT to 1.42W e after ∼2000 h of testing, while that of the MAR-03 unicouple decreased 25.37% from 0.67 to 0.5W e after 261 h of testing at the above temperatures. The estimated peak efficiency of the MAY-04 unicouple, shortly after BOT (10.65%), was only ∼0.37% points lower than the theoretical value, calculated assuming zero side heat losses and zero contact resistance per leg

  13. Repetitive transarterial chemoembolization (TACE) of liver metastases from gastric cancer: Local control and survival results

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, Thomas J., E-mail: T.Vogl@em.uni-frankfurt.de [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Gruber-Rouh, Tatjana; Eichler, Katrin [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Nour-Eldin, Nour-Eldin A. [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Department of Radiology, Faculty of Medicine, Cairo University, Cairo (Egypt); Trojan, Jörg [Department of Internal Medicine I, Johann Wolfgang Goethe-University Frankfurt (Germany); Zangos, Stephan [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Naguib, Nagy N.N. [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Radiology Department, Faculty of Medicine, Alexandria University, Alexandria (Egypt)

    2013-02-15

    Objective: To evaluate the local tumor control and survival data after transarterial chemoembolization with different drug combinations in the palliative treatment of patients with liver metastases of gastric cancer. Materials and methods: The study was retrospectively performed. 56 patients (mean age, 52.4) with unresectable liver metastases of gastric cancer who did not respond to systemic chemotherapy were repeatedly treated with TACE in 4-week intervals. In total, 310 chemoembolization procedures were performed (mean, 5.5 sessions per patient). The local chemotherapy protocol consisted of mitomycin alone (30.4%), mitomycin and gemcitabine (33.9%), or mitomycin, gemcitabine and cisplatin (35.7%). Embolization was performed with lipiodol and starch microspheres. Local tumor response was evaluated by MRI according to RECIST. Survival data from first chemoembolization were calculated according to the Kaplan–Meier method. Results: The local tumor control was: complete response in 1.8% (n = 1), partial response in 1.8% (n = 1), stable disease in 51.8% (n = 29) and progressive disease in 44.6% (n = 25) of patients. The 1-, 2-, and 3-year survival rate from the start of chemoembolization were 58%, 38%, and 23% respectively. The median and mean survival times were 13 and 27.1 months. A Statistically significant difference between patients treated with different chemotherapy protocols was noted (ρ = 0.045) with the best survival time in the mitomycin, gemcitabine and cisplatin group. Conclusion: Transarterial chemoembolization is a minimally invasive therapy option for palliative treatment of liver metastases in patients with gastric cancer.

  14. Long-Term Results of Percutaneous Bilioenteric Anastomotic Stricture Treatment in Liver-Transplanted Children

    International Nuclear Information System (INIS)

    Moreira, Airton Mota; Carnevale, Francisco Cesar; Tannuri, Uenis; Suzuki, Lisa; Gibelli, Nelson; Maksoud, Joao Gilberto; Cerri, Giovanni Guido

    2010-01-01

    The purpose of this study was to evaluate the mid- and long-term results of percutaneous transhepatic cholangiography (PTC) and biliary drainage in children with isolated bilioenteric anastomotic stenosis (BAS) after pediatric liver transplantation. Sixty-four children underwent PTC from March 1993 to May 2008. Nineteen cholangiograms were normal; 10 showed intrahepatic biliary stenosis and BAS, and 35 showed isolated BAS. Cadaveric grafts were used in 19 and living donor grafts in 16 patients. Four patients received a whole liver, and 31 patients received a left lobe or left lateral segment. Roux-en-Y hepaticojejunostomy was performed in all patients. Indication for PTC was based on clinical, laboratory, and histopathologic findings. In patients with isolated BAS, dilation and biliary catheter placement, with changes every 2 months, were performed. Patients were separated into 4 groups according to number of treatment sessions required. The drainage catheter was removed if cholangiogram showed no significant residual stenosis and normal biliary emptying time after a minimum of 6 months. The relationship between risk factors (recipient's weight 20 months, 4 patients (4 of 35; 11.4%) required 1 additional treatment session (group III), and 1 patient (1 of 35; 2.9%) had a catheter placed at the end of the study period (group IV). Drainage time in group I was significantly shorter than those in groups II, III, and IV (p 0.05). The majority of complications, such as catheter displacement and leakage, were classified as minor; however, 2 patients (5.7%) with hemobilia were noted. Complications increased according to the need for reintervention. In conclusion, balloon dilation and percutaneous drainage placement is safe and effective, and it has long-term patency for children with BAS after liver transplantation. Because of prolonged treatment time, reintervention may be necessary, thereby increasing the complication rate. Balloon dilation and percutaneous drainage

  15. Transjugular liver core biopsy: indications, results, and complications; Transjugulaere Leberstanzbiopsie: Indikationen, Ergebnisse, Komplikationen

    Energy Technology Data Exchange (ETDEWEB)

    Dinkel, H.P.; Wittchen, K.; Hoppe, H.; Triller, J. [Inst. fuer Diagnostische Radiologie, Inselspital, Univ. Bern (Switzerland); Dufour, J.F. [Inst. fuer Klinische Pharmakologie, Inselspital, Univ. Bern (Switzerland); Zimmermann, A. [Inst. fuer Pathologie, Inselspital, Univ. Bern (Switzerland)

    2003-08-01

    Purpose: To evaluate benefit, feasibility, and frequency of complications with transjugular liver biopsy using a semi-automatic Tru-cut system. Materials and Methods: Eighty-five consecutive patients (57 males, 28 females) with various liver disorders (cirrhosis [30], hepatitis [12], acute hepatopathy [34], orthotopic liver transplantation [8], hepatocellular carcinoma [1]), coagulopathies (n=71) and/or ascites (n = 46) were referred to our department for a transjugular liver biopsy. Mean age was 48 {+-} 16 years (range 17 to 75 years). Success and complications were retrospectively evaluated from the radiology reports, pathology reports, and patient files. Success was defined as procuring a tissue specimen that enabled a definite histological diagnosis. The complications included thrombosis at the puncture site, hematoma, cardiac arrhythmia, capsular perforation, hemorrhage, and cardiac damage. Mortality included all deaths within 30 days after the procedure. Procedure-related mortality included all deaths related to the procedure. Results: The procedure was technically successful in 80 patients (94%) and unsuccessful in 5 patients (6%) due to a failed hepatic vein cannulation (1 patient with Budd Chiari syndrome and total liver vein occlusion, 4 patients with unsuitable anatomy). One biopsy pass was made in 22 patients, and two passes were made in 45 and three or more passes in 14 patients, all in a single session. The sample quality was judged by the pathologist as good in 71 of 80 patients (89%) and poor in 8 patients (10%). A diagnosis was not possible in 1 patient. Eight procedure-related complications occurred, which were classified according to the criteria of the society of interventional radiology (SIR) as minor in 5 (3 type A, 2 type B) and major in 3 (1 pneumothorax, type C, 1 nonfatal bleeding, type D, and 1 fatal bleeding, type F). Procedure-related mortality was 1%, overall mortality 15% (mostly due to progressive liver failure). (orig.) [German

  16. In vivo proton MR spectroscopy of normal liver parenchyma: technique and results

    International Nuclear Information System (INIS)

    Mueller, C.; Huebner, F.; Bisdas, S.; Herzog, C.; Hammerstingl, R.M.; Vogl, T.J.; Ackermann, H.; Vorbuchner, M.

    2006-01-01

    Purpose: To analyze the proton magnetic resonance spectroscopic data ( 1 H MRS) of normal liver parenchyma with regard to age, sex, body mass index and location in the liver. Materials and Methods: 45 healthy volunteers age 24 to 65 years were examined with an optimized single-voxel 1 H MRS using a 1.5-T scanner. A spin echo sequence with a TR of 1500 ms and a TE of 135 ms was used, allowing in-phase detection of the choline signal. Weak water suppression was achieved using a chemical shift selective suppression (CHESS) technique. Each examination included the measurement of three voxels with a voxel size of 18 x 18 x 18 mm 3 in different areas of the liver. The volunteers were divided into different age-based groups (young: ≤44 years; older: ≥44 years), BMI (normal weighted: 2 ; obese: >25 kg/m 2 ) and sex. Results: In the acquired spectra different lipid (e.g. [CH 2 ] n ), choline, glutamine, glutamate and glycogenglucose-complex reasonances were detected. The analysis of the spectra, however, only focused on the concentrations of choline and (CH 2 ) n and the relative concentrations of the choline-to-(CH 2 ) n -ratios. In the older volunteers the relative concentration of the choline-to-(CH 2 ) n -ratio was significantly decreased by 0.213±0.193 in comparison to the younger subjects (p=0,031). Further statistical analysis confirmed a significant decrease of the choline-to-(CH 2 ) n -ratio by 0.223±0.180 in obese volunteers compared to volunteers of a standard weight (p=0,016). The significant difference between the choline-to-(CH 2 ) n -ratio female versus male volunteers was calculated with an increase of 0.483±0.172 (p=0,000). The location of the voxel in the liver parenchyma did not yield a signficant difference in the choline-to-(CH 2 ) n -ratio. (orig.)

  17. Study on Biochemical Indices of Liver Function Tests of Albino Rats ...

    African Journals Online (AJOL)

    bilirubin, ALT (in rats fed with palm and groundnut oil-based diet), AST (in rats fed with coconut ... These results therefore, indicate a compromise in liver of rats administered 10% oil - based diet. ..... medicinal plants II: Effects of Aplotaxis lappa.

  18. Nuclear medicine liver function tests for pregnant women and children. Pt. 1

    International Nuclear Information System (INIS)

    Krumbiegel, P.; Faust, H.; Moebius, G.; Hirschberg, K.; Guenther, K.; Schneider, G.

    1985-01-01

    Stable isotopes, such as 13 C, should be substituted for the long-lived radionuclide 14 C in the 14 C breath test when doing liver function tests in children and pregnant women. For comparison 13 C, 15 N-methacetin and 14 C-methacetin were synthesized as suitable diagnostic agents. Methods are described for the measurement of 14 C and 13 C in the breath. After oral administration of labelled methacetin to healthy subjects and patients with liver diseases a good correspondence between 13 C- and 14 C-measurements in the same subject on the one hand, and a good discrimination between controls and patients on the other hand were shown. Findings with regard to 14 C measurements in urine are discussed supporting the supposed advantage of 13 C-methacetin over 14 C-methacetin application. (orig.)

  19. Conventional fuel tank blunt impact tests : test and analysis results

    Science.gov (United States)

    2014-04-02

    The Federal Railroad Administrations Office of Research : and Development is conducting research into fuel tank : crashworthiness. A series of impact tests are planned to : measure fuel tank deformation under two types of dynamic : loading conditi...

  20. HERBE- Analysis of test operation results

    International Nuclear Information System (INIS)

    Pesic, M. et.al.

    1991-01-01

    This document is part of the safety analyses performed for the RB reactor operation with the coupled fast-thermal system HERBE and is part of the final safety report together with the 'Report on test operation of HERBE for the period Dec. 15 1989 - May 15 1990. This report covers the following main topics: determination of reactivity variations dependent on the variations moderator critical level; determination of reactivity for the flooded neutron converter; and the accident analysis of neutron converter flooding

  1. Results of Final Focus Test Beam

    Energy Technology Data Exchange (ETDEWEB)

    Walz, Dieter R

    2003-06-13

    The beam experiments of Final Focus Test Beam (FFTB) started in September 1993 at SLAC, and have produced a 1.7 {micro}m x 75 nm spot of 46 GeV electron beam. A number of new techniques involving two nanometer spot-size monitors have been developed. Several beam diagnostic/tuning schemes are applied to achieve and maintain the small spot. This experiment opens the way toward the nanometer world for future linear colliders.

  2. Results of workplace drug testing in Norway

    Directory of Open Access Journals (Sweden)

    Hilde Marie Erøy Lund

    2011-12-01

    Full Text Available Workplace drug testing is less common in Norway than in many other countries. During the period from 2000-2006, 13469 urine or blood samples from employees in the offshore industry, shipping companies and aviation industry were submitted to the Norwegian Institute of Public Health for drug testing. The samples were analysed for benzodiazepines, illicit drugs, muscle relaxants with sedating properties, opioids and z-hypnotics. In total, 2.9% of the samples were positive for one or more substances. During the study period the prevalence decreased for morphine (from 1.9% to 1.1% and increased for amphetamine (from 0.04% to 0.6%, clonazepam (from 0% to 0.1%, methamphetamine (from 0.04% to 0.6%, nitrazepam (from 0% to 0.4% and oxazepam (from 0.5% to 1.3% (p<0.05. There was no significant change in prevalence for the other substances included in the analytical programme. Illicit drugs were significantly associated with lower age (OR: 0.93, p<0.05. This study found low prevalence of drugs among employees in companies with workplace drug testing programmes in Norway.

  3. Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs

    Energy Technology Data Exchange (ETDEWEB)

    Westra, Inge M. [Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen (Netherlands); Oosterhuis, Dorenda [Division of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, University of Groningen (Netherlands); Groothuis, Geny M.M. [Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen (Netherlands); Olinga, Peter, E-mail: p.olinga@rug.nl [Division of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, University of Groningen (Netherlands)

    2014-01-15

    Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early onset of fibrosis in this model and the effects of antifibrotic compounds. Rat PCLS were incubated for 48 h, viability was assessed by ATP and gene expression of PDGF-B and TGF-β1 and the fibrosis markers Hsp47, αSma and Pcol1A1 and collagen1 protein expressions were determined. The effects of the antifibrotic drugs imatinib, sorafenib and sunitinib, PDGF-pathway inhibitors, and perindopril, valproic acid, rosmarinic acid, tetrandrine and pirfenidone, TGFβ-pathway inhibitors, were determined. After 48 h of incubation, viability of the PCLS was maintained and gene expression of PDGF-B was increased while TGF-β1 was not changed. Hsp47, αSma and Pcol1A1 gene expressions were significantly elevated in PCLS after 48 h, which was further increased by PDGF-BB and TGF-β1. The increased gene expression of fibrosis markers was inhibited by all three PDGF-inhibitors, while TGFβ-inhibitors showed marginal effects. The protein expression of collagen 1 was inhibited by imatinib, perindopril, tetrandrine and pirfenidone. In conclusion, the increased gene expression of PDGF-B and the down-regulation of fibrosis markers by PDGF-pathway inhibitors, together with the absence of elevated TGF-β1 gene expression and the limited effect of the TGFβ-pathway inhibitors, indicated the predominance of the PDGF pathway in the early onset of fibrosis in PCLS. PCLS appear a useful model for research of the early onset of fibrosis and for testing of antifibrotic drugs acting on the PDGF pathway. - Highlights: • During culture, fibrosis markers increased in precision-cut liver slices (PCLS). • Gene expression of PDGF-β was increased, while TGFβ was not changed in rat PCLS. • PDGF-pathway inhibitors down-regulated this increase of fibrosis markers. • TGFβ-pathway inhibitors had only

  4. Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides)

    Science.gov (United States)

    Blum, Jason L.; Nyagode, Beatrice A.; James, Margaret O.; Denslow, Nancy D.

    2010-01-01

    The organochlorine pesticide methoxychlor (MXC) is an environmental estrogen known to stimulate the expression of the egg-yolk protein, vitellogenin (Vtg) in fish species. To begin to understand the underlying mechanisms for how MXC exerts its deleterious effects on the endocrine system, male largemouth bass (Micropterus salmoides) were treated with 2.5, 10, or 25 mg/kg MXC and compared to fish pair-treated with 1 mg/kg 17β-estradiol (E2), and vehicle control. Fish were sacrificed 24, 48, or 72 h following treatment. The liver and testes were then assayed for changes in expression of the three bass estrogen receptors (ERs α, βa, and βb) in tissues, as well as Vtg and cytochrome P450 (CYP) 3A isoform 68 in the liver and steroidogenic acute regulatory protein (StAR) in the testes. In the liver, significant increases in gene expression were seen for each of the genes measured by 24 h and each returned to the level of the vehicle by 72 h. Total testosterone 6β-hydroxylase activity, reflective of CYP3A activity, was also increased by 24 h for all of the exposures. In the testes, ERα was unaffected by any treatment, ERβa was upregulated only by MXC, peaking at 24 h for the 2.5 and 10 mg/kg MXC and at 48 h for the 25 mg/kg MXC treatment. By 72 h, the MXC effects had disappeared, while E2 significantly decreased the expression of ERβa mRNA. ERβb expression in the testes was stimulated by all concentrations of MXC by 24 h and the effect remained up to 72 h, whereas E2 had no effect. Finally, StAR expression was found to also be decreased by E2 and all MXC treatments. However, the effect on StAR expression by E2 occurred within 24 h, while the effect by all concentrations of MXC was not seen until 72 h after treatment. The stimulatory effects of E2 and 25 mg/kg MXC on the expression of the ERs in the liver were opposite to the responses seen in the testes, suggesting an inverted relationship between these two tissue types. These results provide a possible mechanism

  5. American Liver Foundation

    Science.gov (United States)

    ... Cirrhosis Clinical Trials Galactosemia Gilbert Syndrome Hemochromatosis Hepatic Encephalopathy Hepatitis A Hepatitis B Hepatitis C Hepatocellular Carcinoma Lysosomal Acid Lipase Deficiency(LALD) Intrahepatic Cholestasis of Pregnancy (ICP) Liver Biopsy Liver Cancer Liver Cysts Liver Function Tests ...

  6. Changes in liver glycogen reserve in Wistar rats as a result of polysaccharide treatment and single sublethal gamma-irradiation

    International Nuclear Information System (INIS)

    Metodiev, S.; Lambov, V.; Pavlova, N.

    1993-01-01

    The phase changes in the quantity of liver glycogen after single sublethal irradiation are investigated. The lowest concentration levels are registered at days 1, 3, 8 and 13 post irradiation. The effect of polysaccharide radioresistance modulation on the liver glycogen concentration is evaluated. The subcutaneous polysaccharide application of the immuno-active product PL prevents the sharp decrease of the liver glycogen concentration level, as a result of radiation provoked damages. The polysaccharide protection is most effective 5 - 21 days after irradiation. The conclusions are based on enzymic and hystomorphological studies. (author)

  7. AMORE Mo-99 Spike Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Youker, Amanda J. [Argonne National Lab. (ANL), Argonne, IL (United States); Krebs, John F. [Argonne National Lab. (ANL), Argonne, IL (United States); Quigley, Kevin J. [Argonne National Lab. (ANL), Argonne, IL (United States); Byrnes, James P. [Argonne National Lab. (ANL), Argonne, IL (United States); Rotsch, David A [Argonne National Lab. (ANL), Argonne, IL (United States); Brossard, Thomas [Argonne National Lab. (ANL), Argonne, IL (United States); Wesolowski, Kenneth [Argonne National Lab. (ANL), Argonne, IL (United States); Alford, Kurt [Argonne National Lab. (ANL), Argonne, IL (United States); Chemerisov, Sergey [Argonne National Lab. (ANL), Argonne, IL (United States); Vandegrift, George F. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-09-27

    With funding from the National Nuclear Security Administrations Material Management and Minimization Office, Argonne National Laboratory (Argonne) is providing technical assistance to help accelerate the U.S. production of Mo-99 using a non-highly enriched uranium (non-HEU) source. A potential Mo-99 production pathway is by accelerator-initiated fissioning in a subcritical uranyl sulfate solution containing low enriched uranium (LEU). As part of the Argonne development effort, we are undertaking the AMORE (Argonne Molybdenum Research Experiment) project, which is essentially a pilot facility for all phases of Mo-99 production, recovery, and purification. Production of Mo-99 and other fission products in the subcritical target solution is initiated by putting an electron beam on a depleted uranium (DU) target; the fast neutrons produced in the DU target are thermalized and lead to fissioning of U-235. At the end of irradiation, Mo is recovered from the target solution and separated from uranium and most of the fission products by using a titania column. The Mo is stripped from the column with an alkaline solution. After acidification of the Mo product solution from the recovery column, the Mo is concentrated (and further purified) in a second titania column. The strip solution from the concentration column is then purified with the LEU Modified Cintichem process. A full description of the process can be found elsewhere [1–3]. The initial commissioning steps for the AMORE project include performing a Mo-99 spike test with pH 1 sulfuric acid in the target vessel without a beam on the target to demonstrate the initial Mo separation-and-recovery process, followed by the concentration column process. All glovebox operations were tested with cold solutions prior to performing the Mo-99 spike tests. Two Mo-99 spike tests with pH 1 sulfuric acid have been performed to date. Figure 1 shows the flow diagram for the remotely operated Mo-recovery system for the AMORE project

  8. SURVEY RESULTS AND TESTING OF RAILWAY BRIDGES

    Directory of Open Access Journals (Sweden)

    I. H. Haniiev

    2010-03-01

    Full Text Available The article is devoted to the survey and testing of railway bridges by the State Joint-Stock Railway Company «Uzbekiston Temir Yollari» («Uzbekistan Railways». It is stated that in the existing rules on determination of the capacity of bridges the recommendations on taking into account the cumulative deflection to the moment of technical diagnostics of spans on the bridge capacity are absent. The author states on the need to develop a method for determining the wear of spans on restriction of the residual deflection in the bridge floor slabs.

  9. Fort St. Vrain hot functional test results

    International Nuclear Information System (INIS)

    Phelps, R.D.

    1974-01-01

    A description is given of Fort St. Vrain hot functional tests performed to evaluate the initial nonnuclear performance of the primary coolant system and the associated effects on the various internal components of the reactor vessel and primary coolant system. The components included the twelve steam generator modules, the four helium circulators, the PCRV thermal barrier and liner coolant system, the helium purification system, and the primary and secondary closures at each of the PCRV penetrations. Additional objectives included analysis of the parallel operation of the four helium circulators and the performance of several circulator start/stop transients under various conditions of primary coolant temperature and pressure. Vibration and acoustical phenomena within the vessel were measured, recorded, and compared to theoretical analyses; a verification of reverse flow in the shutdown loop steam generator during one loop operation was performed; the PCRV was again observed for its structural response to internal pressure; and comparisons were made relative to data recorded during the initial pressure test completed in July 1971. (U.S.)

  10. Enhanced liver fibrosis test using ELISA assay accurately discriminates advanced stage of liver fibrosis as determined by transient elastography fibroscan in treatment naïve chronic HCV patients.

    Science.gov (United States)

    Omran, Dalia; Yosry, Ayman; Darweesh, Samar K; Nabeel, Mohammed M; El-Beshlawey, Mohammed; Saif, Sameh; Fared, Azza; Hassany, Mohamed; Zayed, Rania A

    2018-02-01

    Evaluation of liver fibrosis stage is crucial in the assessment of chronic HCV patients, regarding decision to start treatment and during follow-up. Our aim was to assess the validity of the enhanced liver fibrosis (ELF) score in discrimination of advanced stage of liver fibrosis in naïve chronic HCV patients. We prospectively evaluated liver fibrosis stage in one hundred eighty-one naïve chronic HCV Egyptian patients by transient elastography (TE)-FibroScan. Patients were categorized into mild to moderate fibrosis (≤F2) group and advanced fibrosis (≥F3) group. The ELF score components, hyaluronic acid (HA), amino-terminal propeptide of type-III-procollagen (PIIINP) and tissue inhibitor of metalloproteinase type-1 (TIMP-1), were done using ELISA test. The mean values of ELF and its individual components significantly correlated with the hepatic fibrosis stage as measured by TE-FibroScan (P value 0.001). ELF cutoff value of 9.8 generated a sensitivity of 77.8%, specificity of 67.1%, area under the receiver operator characteristic curve (AUROC) of 0.76 with 95% confidence interval [CI] (0.68-0.83) for detecting advanced fibrosis (F ≥ 3). ELF panel is a good, reliable noninvasive test and showed comparable results to TE-FibroScan in detecting liver fibrosis stage in treatment naïve chronic HCV patients.

  11. Tests of a photovoltaic pump: first results

    International Nuclear Information System (INIS)

    Petroselli, A.; Pica, M.; Biondi, P.

    2005-01-01

    The paper deals with a first series of tests conducted in Viterbo (42 deg 25 min North, 12 deg 06 min East) on a PV-DC pump. This series lasted eight months - from the first days of January to the end of August 2003 - and involved measurements of: air and PV-module temperatures; solar radiations, both on horizontal surface and tilted module surface; voltage and intensity of the DC currents from the panel; pump pressures and flow rates. In total, as much as 3,150 data were collected every day. The analysis of the data allowed to obtain some simple empirical relations expressing daily pumped water volumes, instantaneous flow rates and system efficiencies as a function of both radiations and total dynamic heads [it

  12. RESULTS OF INITIAL AMMONIA OXIDATION TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Nash, C. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Fowley, M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-12-30

    This memo presents an experimental survey of aqueous phase chemical processes to remove aqueous ammonia from waste process streams. Ammonia is generated in both the current Hanford waste flowsheet and in future waste processing. Much ammonia will be generated in the Low Activity Waste (LAW) melters.i Testing with simulants in glass melters at Catholic University has demonstrated the significant ammonia production.ii The primary reaction there is the reducing action of sugar on nitrate in the melter cold cap. Ammonia has been found to be a problem in secondary waste stabilization. Ammonia vapors are noxious and destruction of ammonia could reduce hazards to waste treatment process personnel. It is easily evolved especially when ammonia-bearing solutions are adjusted to high pH.

  13. Liver transplantation in cirrhotic patients with diabetes mellitus: Midterm results, survival, and adverse events

    OpenAIRE

    Blanco, J.J. (Jose J.); Herrero, J.I. (José Ignacio); Quiroga, J. (Jorge); Sangro, B. (Bruno); Gomez-Manero, N. (Noemí); Pardo, F. (Fernando); Cienfuegos, J.A. (Javier A.)

    2001-01-01

    Liver cirrhosis is frequently associated with diabetes mellitus (DM), and this metabolic complication is also frequent after orthotopic liver transplantation (OLT). The aim of our study is to investigate which factors are associated with DM before and after OLT and their impact on post-OLT evolution. We evaluated the prevalence of DM among 115 liver transplant candidates with cirrhosis and assessed their evolution after OLT (median follow-up, 41 m...

  14. Middleware for big data processing: test results

    Science.gov (United States)

    Gankevich, I.; Gaiduchok, V.; Korkhov, V.; Degtyarev, A.; Bogdanov, A.

    2017-12-01

    Dealing with large volumes of data is resource-consuming work which is more and more often delegated not only to a single computer but also to a whole distributed computing system at once. As the number of computers in a distributed system increases, the amount of effort put into effective management of the system grows. When the system reaches some critical size, much effort should be put into improving its fault tolerance. It is difficult to estimate when some particular distributed system needs such facilities for a given workload, so instead they should be implemented in a middleware which works efficiently with a distributed system of any size. It is also difficult to estimate whether a volume of data is large or not, so the middleware should also work with data of any volume. In other words, the purpose of the middleware is to provide facilities that adapt distributed computing system for a given workload. In this paper we introduce such middleware appliance. Tests show that this middleware is well-suited for typical HPC and big data workloads and its performance is comparable with well-known alternatives.

  15. INTRAVAL test case 1b - modelling results

    International Nuclear Information System (INIS)

    Jakob, A.; Hadermann, J.

    1991-07-01

    This report presents results obtained within Phase I of the INTRAVAL study. Six different models are fitted to the results of four infiltration experiments with 233 U tracer on small samples of crystalline bore cores originating from deep drillings in Northern Switzerland. Four of these are dual porosity media models taking into account advection and dispersion in water conducting zones (either tubelike veins or planar fractures), matrix diffusion out of these into pores of the solid phase, and either non-linear or linear sorption of the tracer onto inner surfaces. The remaining two are equivalent porous media models (excluding matrix diffusion) including either non-linear sorption onto surfaces of a single fissure family or linear sorption onto surfaces of several different fissure families. The fits to the experimental data have been carried out by Marquardt-Levenberg procedure yielding error estimates of the parameters, correlation coefficients and also, as a measure for the goodness of the fits, the minimum values of the χ 2 merit function. The effects of different upstream boundary conditions are demonstrated and the penetration depth for matrix diffusion is discussed briefly for both alternative flow path scenarios. The calculations show that the dual porosity media models are significantly more appropriate to the experimental data than the single porosity media concepts. Moreover, it is matrix diffusion rather than the non-linearity of the sorption isotherm which is responsible for the tailing part of the break-through curves. The extracted parameter values for some models for both the linear and non-linear (Freundlich) sorption isotherms are consistent with the results of independent static batch sorption experiments. From the fits, it is generally not possible to discriminate between the two alternative flow path geometries. On the basis of the modelling results, some proposals for further experiments are presented. (author) 15 refs., 23 figs., 7 tabs

  16. Text Messaging Improves Participation in Laboratory Testing in Adolescent Liver Transplant Patients.

    Science.gov (United States)

    McKenzie, Rebecca B; Berquist, William E; Foley, Megan A; Park, K T; Windsheimer, Jered E; Litt, Iris F

    In solid organ transplant patients, non-participation in all aspects of the medical regimen is a prevalent problem associated with adverse consequences particularly in the adolescent and young adult (AYA) age group. This study is the first to evaluate the feasibility, utility and impact of a text messaging (TM) intervention to improve participation in laboratory testing in adolescent liver transplant patients. AYA patients, aged 12 to 21 years, were recruited for a prospective pilot trial evaluating a TM intervention delivered over a 1-year period. The intervention involved automated TM reminders with feedback administered according to a prescribed laboratory testing frequency. Participation rate in laboratory testing after the intervention was compared to the year prior. Patient responses and feedback by text and survey were used to assess feasibility, acceptability and use of the intervention. Forty-two patients were recruited and 33 patients remained enrolled for the study duration. Recipients of the TM intervention demonstrated a significant improvement in participation rate in laboratory testing from 58% to 78% (Prate was also significantly higher than in non-intervention controls (P=.003). There was a high acceptability, response rate and a significant correlation with reported versus actual completion of laboratory tests by TM. TM reminders significantly improved participation in laboratory testing in AYA liver transplant patients. The intervention demonstrated feasibility, acceptability, and use with a high proportion of patients who engaged in and perceived a benefit from using this technology.

  17. Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions

    Directory of Open Access Journals (Sweden)

    Nora Freyer

    2018-03-01

    Full Text Available The accurate prediction of hepatotoxicity demands validated human in vitro models that can close the gap between preclinical animal studies and clinical trials. In this study we investigated the response of primary human liver cells to toxic drug exposure in a perfused microscale 3D liver bioreactor. The cellularized bioreactors were treated with 5, 10, or 30 mM acetaminophen (APAP used as a reference substance. Lactate production significantly decreased upon treatment with 30 mM APAP (p < 0.05 and ammonia release significantly increased in bioreactors treated with 10 or 30 mM APAP (p < 0.0001, indicating APAP-induced dose-dependent toxicity. The release of prostaglandin E2 showed a significant increase at 30 mM APAP (p < 0.05, suggesting an inflammatory reaction towards enhanced cellular stress. The expression of genes involved in drug metabolism, antioxidant reactions, urea synthesis, and apoptosis was differentially influenced by APAP exposure. Histological examinations revealed that primary human liver cells in untreated control bioreactors were reorganized in tissue-like cell aggregates. These aggregates were partly disintegrated upon APAP treatment, lacking expression of hepatocyte-specific proteins and transporters. In conclusion, our results validate the suitability of the microscale 3D liver bioreactor to detect hepatotoxic effects of drugs in vitro under perfusion conditions.

  18. Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions.

    Science.gov (United States)

    Freyer, Nora; Greuel, Selina; Knöspel, Fanny; Gerstmann, Florian; Storch, Lisa; Damm, Georg; Seehofer, Daniel; Foster Harris, Jennifer; Iyer, Rashi; Schubert, Frank; Zeilinger, Katrin

    2018-03-15

    The accurate prediction of hepatotoxicity demands validated human in vitro models that can close the gap between preclinical animal studies and clinical trials. In this study we investigated the response of primary human liver cells to toxic drug exposure in a perfused microscale 3D liver bioreactor. The cellularized bioreactors were treated with 5, 10, or 30 mM acetaminophen (APAP) used as a reference substance. Lactate production significantly decreased upon treatment with 30 mM APAP ( p < 0.05) and ammonia release significantly increased in bioreactors treated with 10 or 30 mM APAP ( p < 0.0001), indicating APAP-induced dose-dependent toxicity. The release of prostaglandin E2 showed a significant increase at 30 mM APAP ( p < 0.05), suggesting an inflammatory reaction towards enhanced cellular stress. The expression of genes involved in drug metabolism, antioxidant reactions, urea synthesis, and apoptosis was differentially influenced by APAP exposure. Histological examinations revealed that primary human liver cells in untreated control bioreactors were reorganized in tissue-like cell aggregates. These aggregates were partly disintegrated upon APAP treatment, lacking expression of hepatocyte-specific proteins and transporters. In conclusion, our results validate the suitability of the microscale 3D liver bioreactor to detect hepatotoxic effects of drugs in vitro under perfusion conditions.

  19. Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks

    Directory of Open Access Journals (Sweden)

    David Sadowsky

    2016-11-01

    Full Text Available Background: Ex vivo machine perfusion (MP can better preserve organs for transplantation. We have recently reported on the first application of a MP protocol in which liver allografts were fully oxygenated, under dual pressures and subnormothermic conditions, with a new hemoglobin-based oxygen carrier solution specifically developed for ex vivo utilization. In those studies, MP improved organ function post-operatively and reduced inflammation in porcine livers. Herein, we sought to refine our knowledge regarding the impact of MP by defining dynamic networks of inflammation in both tissue and perfusate. Methods: Porcine liver allografts were preserved either with MP (n = 6 or with cold static preservation (CSP; n = 6, then transplanted orthotopically after 9 h of preservation. Fourteen inflammatory mediators were measured in both tissue and perfusate during liver preservation at multiple time points, and analyzed using Dynamic Bayesian Network (DyBN inference to define feedback interactions, as well as Dynamic Network Analysis (DyNA to define the time-dependent development of inflammation networks.Results: Network analyses of tissue and perfusate suggested an NLRP3 inflammasome-regulated response in both treatment groups, driven by the pro-inflammatory cytokine interleukin (IL-18 and the anti-inflammatory mediator IL-1 receptor antagonist (IL-1RA. Both DyBN and DyNA suggested a reduced role of IL-18 and increased role of IL-1RA with MP, along with increased liver damage with CSP. DyNA also suggested divergent progression of responses over the 9 h preservation time, with CSP leading to a stable pattern of IL-18-induced liver damage and MP leading to a resolution of the pro-inflammatory response. These results were consistent with prior clinical, biochemical, and histological findings after liver transplantation. Conclusion: Our results suggest that analysis of dynamic inflammation networks in the setting of liver preservation may identify novel

  20. Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.

    Science.gov (United States)

    Calès, Paul; Halfon, Philippe; Batisse, Dominique; Carrat, Fabrice; Perré, Philippe; Penaranda, Guillaume; Guyader, Dominique; d'Alteroche, Louis; Fouchard-Hubert, Isabelle; Michelet, Christian; Veillon, Pascal; Lambert, Jérôme; Weiss, Laurence; Salmon, Dominique; Cacoub, Patrice

    2010-08-01

    We compared 5 non-specific and 2 specific blood tests for liver fibrosis in HCV/HIV co-infection. Four hundred and sixty-seven patients were included into derivation (n=183) or validation (n=284) populations. Within these populations, the diagnostic target, significant fibrosis (Metavir F > or = 2), was found in 66% and 72% of the patients, respectively. Two new fibrosis tests, FibroMeter HICV and HICV test, were constructed in the derivation population. Unadjusted AUROCs in the derivation population were: APRI: 0.716, Fib-4: 0.722, Fibrotest: 0.778, Hepascore: 0.779, FibroMeter: 0.783, HICV test: 0.822, FibroMeter HICV: 0.828. AUROCs adjusted on classification and distribution of fibrosis stages in a reference population showed similar values in both populations. FibroMeter, FibroMeter HICV and HICV test had the highest correct classification rates in F0/1 and F3/4 (which account for high predictive values): 77-79% vs. 70-72% in the other tests (p=0.002). Reliable individual diagnosis based on predictive values > or = 90% distinguished three test categories: poorly reliable: Fib-4 (2.4% of patients), APRI (8.9%); moderately reliable: Fibrotest (25.4%), FibroMeter (26.6%), Hepascore (30.2%); acceptably reliable: HICV test (40.2%), FibroMeter HICV (45.6%) (ptests). FibroMeter HICV classified all patients into four reliable diagnosis intervals ( or =F1, > or =F2) with an overall accuracy of 93% vs. 79% (pfibrosis. Tests designed for HCV infections are less effective in HIV/HCV infections. A specific test, like FibroMeter HICV, was the most interesting test for diagnostic accuracy, correct classification profile, and a reliable diagnosis. With reliable diagnosis intervals, liver biopsy can therefore be avoided in all patients. Copyright 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  1. Large bundle BWR test CORA-18: Test results

    International Nuclear Information System (INIS)

    Hagen, S.; Hofmann, P.; Noack, V.; Sepold, L.; Schanz, G.; Schumacher, G.

    1998-04-01

    The CORA out-of-pile experiments are part of the international Severe Fuel Damage (SFD) Program. They were performed to provide information on the damage progression of Light Water Reactor (LWR) fuel elements in Loss-of-coolant Accidents in the temperature range 1200 C to 2400 C. CORA-18 was the large BWR bundle test corresponding to the PWR test CORA-7. It should investigate if there exists an influence of the BWR bundle size on the fuel damage behaviour. Therefore, the standard-type BWR CORA bundle with 18 fuel rod simulators was replaced by a large bundle with two additional surrounding rows of 30 rods (48 rods total). Power input and steam flow were increased proportionally to the number of fuel rod simulators to give the same initial heat-up rate of about 1 K/s as in the smaller bundles. Emphasis was put on the initial phase of the damage progression. More information on the chemical composition of initial and intermediate interaction products and their relocation behaviour should be obtained. Therefore, power and steam input were terminated after the onset of the temperature escalation. (orig.) [de

  2. Stirling convertor performance mapping test results

    Science.gov (United States)

    Qiu, Songgang; Peterson, Allen A.; White, Maurice A.; Faultersack, Franklyn; Redinger, Darin L.; Petersen, Stephen L.

    2002-01-01

    The Department of Energy (DOE) has selected Free-Piston Stirling Convertors as a technology for future advanced radioisotope space power systems. In August 2000, DOE awarded competitive Phase I, Stirling Radioisotope Generator (SRG) power system integration contracts to three major aerospace contractors, resulting in SRG conceptual designs in February 2001. All three contractors based their designs on the Technology Demonstration Convertor (TDC) developed by Stirling Technology Company (STC) for DOE. The contract award to a single system integration contractor for Phases II and III of the SRG program is anticipated in late 2001. The first potential SRG mission is targeted for a Mars rover. Recent TDC performance data are provided in this paper, together with predictions from Stirling simulation models. .

  3. A stepwise algorithm using an at-a-glance first-line test for the non-invasive diagnosis of advanced liver fibrosis and cirrhosis.

    Science.gov (United States)

    Boursier, Jérôme; de Ledinghen, Victor; Leroy, Vincent; Anty, Rodolphe; Francque, Sven; Salmon, Dominique; Lannes, Adrien; Bertrais, Sandrine; Oberti, Frederic; Fouchard-Hubert, Isabelle; Calès, Paul

    2017-06-01

    Chronic liver diseases (CLD) are common, and are therefore mainly managed by non-hepatologists. These physicians lack access to the best non-invasive tests of liver fibrosis, and consequently cannot accurately determine the disease severity. Referral to a hepatologist is then needed. We aimed to implement an algorithm, comprising a new first-line test usable by all physicians, for the detection of advanced liver fibrosis in all CLD patients. Diagnostic study: 3754 CLD patients with liver biopsy were 2:1 randomized into derivation and validation sets. Prognostic study: longitudinal follow-up of 1275 CLD patients with baseline fibrosis tests. Diagnostic study: the easy liver fibrosis test (eLIFT), an "at-a-glance" sum of points attributed to age, gender, gamma-glutamyl transferase, aspartate aminotransferase (AST), platelets and prothrombin time, was developed for the diagnosis of advanced fibrosis. In the validation set, eLIFT and fibrosis-4 (FIB4) had the same sensitivity (78.0% vs. 76.6%, p=0.470) but eLIFT gave fewer false positive results, especially in patients ≥60years old (53.8% vs. 82.0%, ptest. FibroMeter with vibration controlled transient elastography (VCTE) was the most accurate among the eight fibrosis tests evaluated. The sensitivity of the eLIFT-FM VCTE algorithm (first-line eLIFT, second-line FibroMeter VCTE ) was 76.1% for advanced fibrosis and 92.1% for cirrhosis. Prognostic study: patients diagnosed as having "no/mild fibrosis" by the algorithm had excellent liver-related prognosis with thus no need for referral to a hepatologist. The eLIFT-FM VCTE algorithm extends the detection of advanced liver fibrosis to all CLD patients and reduces unnecessary referrals of patients without significant CLD to hepatologists. Blood fibrosis tests and transient elastography accurately diagnose advanced liver fibrosis in the large population of patients having chronic liver disease, but these non-invasive tests are only currently available in specialized

  4. Characterization of unifocal liver lesions with pulse inversion harmonic imaging after Levovist injection: preliminary results

    International Nuclear Information System (INIS)

    Bertolotto, M.; Dalla Palma, L.; Quaia, E.; Locatelli, M.

    2000-01-01

    The aim of this study was to evaluate capabilities of pulse inversion harmonic imaging (PIHI) in characterization of unifocal liver lesions. We evaluated with PIHI (HDI5000, ATL, Bothell, Wash.) and spiral CT 46 consecutive patients with a single liver lesion identified by fundamental US [7 hepatocellular carcinomas (HCC), 2 cholangiocarcinomas, 7 focal nodular hyperplasias (FNH), 17 hemangiomas and 13 metastases]. The PIHI was performed before and 30 s, 2 and 4 min after bolus administration of Levovist (2.5 g, 300 mg/ml). Scans were digitally stored and reviewed using a dedicated software. Hepatocellular carcinoma was hyperechoic on 30-s scan, and hypoechoic (n = 5) or isoechoic (n = 2) on 2-min scan. Cholangiocarcinoma had inhomogeneous persistent enhancement. Focal nodular hyperplasia was hyperechoic (n = 5) or isoechoic (n = 2) on 30-s scan, hyperechoic (n = 4), isoechoic (n = 2) or slightly hypoechoic (n = 1) on 2-min scan. Large hemangioma revealed peripheral enhancement on 30-s scan which extended centripetally on 2-min scan. Small hemangioma appeared isoechoic on 2-min scan in all but two cases in which they were hypoechoic on 2-min scans and hyperechoic on 4-min scan. Metastasis was hypoechoic on all scans, 70 % with rim enhancement. Similar changes in enhancement pattern have been observed at spiral CT. The 30-s and the 2-min scans revealed a conclusive importance in characterization of HCC, cholangiocarcinoma, and large hemangioma. The 2-min scan often furnished enough information for characterization of small hemangioma and metastasis. The 4-min scan allowed characterization of two hemangiomas which appeared hypoechoic on 2-min scans. In the other cases it did not provide further information. Diagnosis of FNH is usually reached with Colour Doppler US; PIHI should be used when colour Doppler is biased by artefacts or when colour Doppler findings are not characteristic. Our results seem to show that PIHI could be a valuable alternative diagnostic

  5. Results of correlation of values of individual behaviour of rats with liver tryptophan pyrrolase activity.

    Science.gov (United States)

    Tikal, K; Kunz, K

    1976-01-01

    A significant negative correlation was found between the individual animal's horizontal activity in an open field and liver tryptophan pyrrolase (LTP) activity. On the other hand, the duration of immobility in an open field correlated postively and significantly with liver tryptophan pyrrolase activity.

  6. 99m-Tc-IDA scintigraphic demonstrability of biliary elements and liver function tests in hepatobiliary diseases

    International Nuclear Information System (INIS)

    Kim, C.Y.; Bahk, Y.W.

    1982-01-01

    In the present communication, the results will be reported on a clinical study of how well scintigraphic visualization of the hepatobiliary elements and several commonly used clinical liver function tests correlate each other in various diseases of the hepatobiliary system. The demonstrability of the biliary tract, gallblader (GB) and duodenum was rather closely paralleled to serum bilirubin level and less closely to alkaline phosphatase and rather poorly to SGOT and SGPT. The biliary tree could not be visualized scintigraphically when bilirubin exceeded 10 mg/dl

  7. Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors

    Energy Technology Data Exchange (ETDEWEB)

    Ibarra, Rafael A.; Rojas, Daniel; Sanabria, Juan R. [Dept. of Surgery, Univ. Hospitals-Case Medical Center, Cleveland, OH (United States)], email: juan.sanabria@uhhospitals.org [and others

    2012-05-15

    Background. An excess of 100 000 individuals are diagnosed with primary liver tumors every year in USA but less than 20% of those patients are amenable to definitive surgical management due to advanced local disease or comorbidities. Local therapies to arrest tumor growth have limited response and have shown no improvement on patient survival. Stereotactic body radiotherapy (SBRT) has emerged as an alternative local ablative therapy. The purpose of this study was to evaluate the tumor response to SBRT in a combined multicenter database. Study design. Patients with advanced hepatocellular carcinoma (HCC, n = 21) or intrahepatic cholangiocarcinoma (ICC, n = 11) treated with SBRT from four Academic Medical Centers were entered into a common database. Statistical analyses were performed for freedom from local progression (FFLP) and patient survival. Results. The overall FFLP for advanced HCC was 63% at a median follow-up of 12.9 months. Median tumor volume decreased from 334.2 to 135 cm{sup 3} (p < 0.004). The median time to local progression was 6.3 months. The 1- and 2-years overall survival rates were 87% and 55%, respectively. Patients with ICC had an overall FFLP of 55.5% at a median follow-up of 7.8 months. The median time to local progression was 4.2 months and the six-month and one-year overall survival rates were 75% and 45%, respectively. The incidence of grade 1-2 toxicities, mostly nausea and fatigue, was 39.5%. Grade 3 and 4 toxicities were present in two and one patients, respectively. Conclusion. Higher rates of FFLP were achieved by SBRT in the treatment of primary liver malignancies with low toxicity.

  8. Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C

    Directory of Open Access Journals (Sweden)

    Boursier Jérôme

    2011-11-01

    Full Text Available Abstract Background Non-invasive tests have been constructed and evaluated mainly for binary diagnoses such as significant fibrosis. Recently, detailed fibrosis classifications for several non-invasive tests have been developed, but their accuracy has not been thoroughly evaluated in comparison to liver biopsy, especially in clinical practice and for Fibroscan. Therefore, the main aim of the present study was to evaluate the accuracy of detailed fibrosis classifications available for non-invasive tests and liver biopsy. The secondary aim was to validate these accuracies in independent populations. Methods Four HCV populations provided 2,068 patients with liver biopsy, four different pathologist skill-levels and non-invasive tests. Results were expressed as percentages of correctly classified patients. Results In population #1 including 205 patients and comparing liver biopsy (reference: consensus reading by two experts and blood tests, Metavir fibrosis (FM stage accuracy was 64.4% in local pathologists vs. 82.2% (p -3 in single expert pathologist. Significant discrepancy (≥ 2FM vs reference histological result rates were: Fibrotest: 17.2%, FibroMeter2G: 5.6%, local pathologists: 4.9%, FibroMeter3G: 0.5%, expert pathologist: 0% (p -3. In population #2 including 1,056 patients and comparing blood tests, the discrepancy scores, taking into account the error magnitude, of detailed fibrosis classification were significantly different between FibroMeter2G (0.30 ± 0.55 and FibroMeter3G (0.14 ± 0.37, p -3 or Fibrotest (0.84 ± 0.80, p -3. In population #3 (and #4 including 458 (359 patients and comparing blood tests and Fibroscan, accuracies of detailed fibrosis classification were, respectively: Fibrotest: 42.5% (33.5%, Fibroscan: 64.9% (50.7%, FibroMeter2G: 68.7% (68.2%, FibroMeter3G: 77.1% (83.4%, p -3 (p -3. Significant discrepancy (≥ 2 FM rates were, respectively: Fibrotest: 21.3% (22.2%, Fibroscan: 12.9% (12.3%, FibroMeter2G: 5.7% (6

  9. Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.

    Science.gov (United States)

    Boursier, J; Brochard, C; Bertrais, S; Michalak, S; Gallois, Y; Fouchard-Hubert, I; Oberti, F; Rousselet, M-C; Calès, P

    2014-07-01

    Recent longitudinal studies have emphasised the prognostic value of noninvasive tests of liver fibrosis and cross-sectional studies have shown their combination significantly improves diagnostic accuracy. To compare the prognostic accuracy of six blood fibrosis tests and liver biopsy, and evaluate if test combination improves the liver-prognosis assessment in chronic hepatitis C (CHC). A total of 373 patients with compensated CHC, liver biopsy (Metavir F) and blood tests targeting fibrosis (APRI, FIB4, Fibrotest, Hepascore, FibroMeter) or cirrhosis (CirrhoMeter) were included. Significant liver-related events (SLRE) and liver-related deaths were recorded during follow-up (started the day of biopsy). During the median follow-up of 9.5 years (3508 person-years), 47 patients had a SLRE and 23 patients died from liver-related causes. For the prediction of first SLRE, most blood tests allowed higher prognostication than Metavir F [Harrell C-index: 0.811 (95% CI: 0.751-0.868)] with a significant increase for FIB4: 0.879 [0.832-0.919] (P = 0.002), FibroMeter: 0.870 [0.812-0.922] (P = 0.005) and APRI: 0.861 [0.813-0.902] (P = 0.039). Multivariate analysis identified FibroMeter, CirrhoMeter and sustained viral response as independent predictors of first SLRE. CirrhoMeter was the only independent predictor of liver-related death. The combination of FibroMeter and CirrhoMeter classifications into a new FM/CM classification improved the liver-prognosis assessment compared to Metavir F staging or single tests by identifying five subgroups of patients with significantly different prognoses. Some blood fibrosis tests are more accurate than liver biopsy for determining liver prognosis in CHC. A new combination of two complementary blood tests, one targeted for fibrosis and the other for cirrhosis, optimises assessment of liver-prognosis. © 2014 John Wiley & Sons Ltd.

  10. The White test: a new dye test for intraoperative detection of bile leakage during major liver resection.

    Science.gov (United States)

    Nadalin, Silvio; Li, Jun; Lang, Hauke; Sotiropoulos, Georgios C; Schaffer, Randolph; Radtke, Arnold; Saner, Fuat; Broelsch, Christoph E; Malagó, Massimo

    2008-04-01

    To describe a new intraoperative bile leakage test in patients undergoing a major liver resection aimed to combine the advantages of each of the other standard bile leakage tests (accurate visualization of leaks, reproducibility, and ease of use) without their disadvantages. At the end of the major hepatic resection, 10 to 30 mL of sterile fat emulsion, 5%, is injected via an olive-tip cannula through the cystic duct while manually occluding the distal common bile duct. As the biliary tree fills with fat emulsion solution, leakage of the white fluid is visualized on the raw surface of the liver resection margin. The detected leakages are closed by means of single stitches. Afterwards, the residual fat emulsion on the resection surface is washed off with saline and the White test is repeated to detect and/or exclude additional bile leakages. At the end, residual fat emulsion is washed out from the biliary tract by a low-pressure infusion of saline solution. Intraoperatively, additional potential bile leakages (not seen using a conventional saline bile leakage test) were identified in 74% of our patients. Postoperative bile leakages (within 30 days) occurred in only 5.1% of patients when the White test was used. No adverse effects related to this technique were observed. The White test has clear advantages in comparison with other bile leakage tests: it precisely detects bile leakages, regardless of size; it does not stain the resection surface, allowing it to be washed off and repeated ad infinitum; and it is safe, quick, and inexpensive.

  11. Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.

    Directory of Open Access Journals (Sweden)

    Xiang Yi Kong

    Full Text Available Ablation of glycosylated lysosomal membrane protein (GLMP, formerly known as NCU-G1 has been shown to cause chronic liver injury which progresses into liver fibrosis in mice. Both lysosomal dysfunction and chronic liver injury can cause metabolic dysregulation. Glmp gt/gt mice (formerly known as Ncu-g1gt/gt mice were studied between 3 weeks and 9 months of age. Body weight gain and feed efficiency of Glmp gt/gt mice were comparable to wild type siblings, only at the age of 9 months the Glmp gt/gt siblings had significantly reduced body weight. Reduced size of epididymal fat pads was accompanied by hepatosplenomegaly in Glmp gt/gt mice. Blood analysis revealed reduced levels of blood glucose, circulating triacylglycerol and non-esterified fatty acids in Glmp gt/gt mice. Increased flux of glucose, increased de novo lipogenesis and lipid accumulation were detected in Glmp gt/gt primary hepatocytes, as well as elevated triacylglycerol levels in Glmp gt/gt liver homogenates, compared to hepatocytes and liver from wild type mice. Gene expression analysis showed an increased expression of genes involved in fatty acid uptake and lipogenesis in Glmp gt/gt liver compared to wild type. Our findings are in agreement with the metabolic alterations observed in other mouse models lacking lysosomal proteins, and with alterations characteristic for advanced chronic liver injury.

  12. Assessment of pathologic increase in liver stiffness enables earlier diagnosis of CFLD: Results from a prospective longitudinal cohort study.

    Directory of Open Access Journals (Sweden)

    Victoria Klotter

    Full Text Available About 30% of patients with Cystic Fibrosis (CF develop CF-associated liver disease (CFLD. Recent studies have shown that transient elastography (TE, as a method to quantify liver stiffness, allows non-invasive diagnosis of CFLD in adults and children with CF. Within this study we aimed to prospectively identify patients at risk for development of CFLD by longitudinal analysis of liver stiffness and fibrosis scores in a 5-year follow-up. 36 pediatric and 16 adult patients with initial liver stiffness below the cut-off value indicative of CFLD (6.3 kPa were examined by transient elastography for 4-5 years. TE, APRI-, and FIB-4-scores were assessed and compared by Kruskal-Wallis test and receiver operating characteristic (ROC-analysis. Frequencies were compared by Chi2-test. Among the 36 patients participating in this study, a subgroup of 9 patients developed liver stiffness >6.3 kPa after 4-5 years with an increase of ΔTE >0.38 kPa/a (the group with increasing liver stiffness was labelled TEinc. APRI- and FIB-4 scores confirmed the rationale for grouping. The frequency of CFLD assessed by conventional diagnosis was significantly higher in TEinc-group compared to the control group (TEnorm. None of the adult CF patients matched criteria for TEinc-group. For the first time it was shown that the non-invasive longitudinal assessment of TE allows identification of patients with progression of CFLD in a subgroup of juvenile but not in adult CF patients. Comparing TE to conventional fibrosis-scores underlined the strength of the continuous assessment of liver stiffness for the exact diagnosis of progressive CFLD. The newly described cut-off for pathologic increase of liver stiffness, ΔTEcutoff = 0.38kPa/a, might enable to detect developing CFLD using consequent follow up TE measurements before reaching the level of stiffness indicating established CFLD. Nevertheless, the limited size of the analyzed cohort should encourage a prospective, multi

  13. Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs

    NARCIS (Netherlands)

    Westra, Inge M.; Oosterhuis, Dorenda; Groothuis, Geny M. M.; Olinga, Peter

    2014-01-01

    Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early onset of fibrosis in this model and the effects of antifibrotic compounds. Rat PCLS were incubated for

  14. Elevated Liver Enzymes

    Science.gov (United States)

    Symptoms Elevated liver enzymes By Mayo Clinic Staff Elevated liver enzymes may indicate inflammation or damage to cells in the liver. Inflamed or ... than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, which can result in elevated ...

  15. Cirrhosis Diagnosis and Liver Fibrosis Staging: Transient Elastometry Versus Cirrhosis Blood Test.

    Science.gov (United States)

    Calès, Paul; Boursier, Jérôme; Oberti, Frédéric; Bardou, Derek; Zarski, Jean-Pierre; de Lédinghen, Victor

    2015-07-01

    Elastometry is more accurate than blood tests for cirrhosis diagnosis. However, blood tests were developed for significant fibrosis, with the exception of CirrhoMeter developed for cirrhosis. We compared the performance of Fibroscan and CirrhoMeter, and classic binary cirrhosis diagnosis versus new fibrosis staging for cirrhosis diagnosis. The diagnostic population included 679 patients with hepatitis C and liver biopsy (Metavir staging and morphometry), Fibroscan, and CirrhoMeter. The prognostic population included 1110 patients with chronic liver disease and both tests. Binary diagnosis: AUROCs for cirrhosis were: Fibroscan: 0.905; CirrhoMeter: 0.857; and P=0.041. Accuracy (Youden cutoff) was: Fibroscan: 85.4%; CirrhoMeter: 79.2%; and PFibrosis classification provided 6 classes (F0/1, F1/2, F2±1, F3±1, F3/4, and F4). Accuracy was: Fibroscan: 88.2%; CirrhoMeter: 88.8%; and P=0.77. A simplified fibrosis classification comprised 3 categories: discrete (F1±1), moderate (F2±1), and severe (F3/4) fibrosis. Using this simplified classification, CirrhoMeter predicted survival better than Fibroscan (respectively, χ=37.9 and 19.7 by log-rank test), but both predicted it well (Ptest). Comparison: binary diagnosis versus fibrosis classification, respectively, overall accuracy: CirrhoMeter: 79.2% versus 88.8% (PFibrosis classification should be preferred over binary diagnosis. A cirrhosis-specific blood test markedly attenuates the accuracy deficit for cirrhosis diagnosis of usual blood tests versus transient elastometry, and may offer better prognostication.

  16. Interpreting Results from the Standardized UXO Test Sites

    National Research Council Canada - National Science Library

    May, Michael; Tuley, Michael

    2007-01-01

    ...) and the Environmental Security Technology Certification Program (ESCTP) to complete a detailed analysis of the results of testing carried out at the Standardized Unexploded Ordnance (UXO) Test Sites...

  17. Determinants of Active Longevity: Results of a Survey of Vologda Long-Livers

    Directory of Open Access Journals (Sweden)

    Ol’ga Nikolaevna Kalachikova

    2016-11-01

    Full Text Available Population ageing is a major demographic challenge for the majority of developed and developing countries. The implications of population ageing are not reduced to purely economic aspects (increasing the burden on the working population, growing deficit of pension funds and they lead to a change in people’s attitude toward the elderly as a social group, the resource potential of which should be disclosed, the task being of major importance for any “ageing” country. At the same time, a priority of population policy in any country is to increase life expectancy of its citizens. Thus, given the forecast reduction in demand on the labor market and possible raise of the retirement age in Russia, authorities at all levels focus not just on the increase in life expectancy, but on active longevity of its citizens, which is reflected in the maintenance of physical and moral health of man for as long as possible. The paper investigates determinants of active longevity. The first part of the paper provides statistical analysis of prevalence of this phenomenon in various regions of the world and Russia. The authors draw a conclusion that here the role of geographical and climatic conditions on a global scale is insignificant. However, it is revealed that the number of long-livers in the vast majority of cases is directly proportional to the level of socio-economic development of the territory. The second part of the paper presents the results of sociological research on the determinants of active longevity based on interviews with long-livers in Vologda. The data obtained show that among the factors under consideration it is not the biological (genetic or geographic factors that are of the greatest importance to the increase in life expectancy, rather it is the behavioral factors such as physical activity, balanced nutrition and a correct day regimen, absence of bad habits, involvement in social activities and extensive social environment, high labor

  18. Local recurrence after microwave thermosphere ablation of malignant liver tumors: results of a surgical series.

    Science.gov (United States)

    Takahashi, Hideo; Kahramangil, Bora; Berber, Eren

    2018-04-01

    Microwave thermosphere ablation is a new treatment modality that creates spherical ablation zones using a single antenna. This study aims to analyze local recurrence associated with this new treatment modality in patients with malignant liver tumors. This is a prospective clinical study of patients who underwent microwave thermosphere ablation of malignant liver tumors between September 2014 and March 2017. Clinical, operative, and oncologic parameters were analyzed using Kaplan-Meier survival and Cox proportional hazards model. One hundred patients underwent 301 ablations. Ablations were performed laparoscopically in 87 and open in 13 patients. Pathology included neuroendocrine liver metastasis (n = 115), colorectal liver metastasis (n = 100), hepatocellular cancer (n = 21), and other tumor types (n = 65). Ninety-day morbidity was 7% with one not procedure-related mortality. Median follow-up was 16 months with 65% of patients completing at least 12 months of follow-up. The rate of local tumor recurrence rate per lesion was 6.6% (20/301). Local tumor, new hepatic, and extrahepatic recurrences were detected in 15%, 40%, and 40% of patients, respectively. Local recurrence rate per pathology was 12% for both colorectal liver metastasis (12/100) and other metastatic tumors (8/65). No local recurrence was observed to date in the neuroendocrine liver metastasis and in the limited number of patients with hepatocellular cancers. Tumor size >3 cm and tumor type were independent predictors of local recurrence. This is the first study to analyze local recurrence after microwave thermosphere ablation of malignant liver tumors. Short-term local tumor control rate compares favorably with that reported for radiofrequency and other microwave technologies in the literature. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Percutaneous Liver Biopsy after Living Donor Liver Transplantation Resulting in Fulminant Hepatic Failure: The First Reported Case of Hepatic Compartment Syndrome

    Directory of Open Access Journals (Sweden)

    Nicholas N. Nissen

    2010-01-01

    Full Text Available A 28-year-old female who underwent live donor liver transplantation 3 years prior presented after percutaneous liver biopsy with abdominal and shoulder pain, nausea, vomiting, and elevated liver enzymes. Computed tomography (CT showed an intrahepatic and subcapsular hematoma. There was a progressive increase in liver enzymes, bilirubin, and INR and a decline in hemoglobin. Subsequent CT imaging revealed flattening of the portal vein consistent with compression by the enlarging hematoma. Liver failure ensued and the patient required urgent retransplantation. The explant demonstrated ischemic necrosis of greater than 90% of the liver parenchyma. We report this case of “Hepatic Compartment Syndrome” leading to fulminant hepatic failure.

  20. Routine Laboratory Blood Tests May Diagnose Significant Fibrosis in Liver Transplant Recipients with Chronic Hepatitis C: A 10 Year Experience

    OpenAIRE

    Sheen, Victoria; Nguyen, Heajung; Jimenez, Melissa; Agopian, Vatche; Vangala, Sitaram; Elashoff, David; Saab, Sammy

    2016-01-01

    Background and Aims: The aims of our study were to determine whether routine blood tests, the aspartate aminotransferase (AST) to Platelet Ratio Index (APRI) and Fibrosis 4 (Fib-4) scores, were associated with advanced fibrosis and to create a novel model in liver transplant recipients with chronic hepatitis C virus (HCV). Methods: We performed a cross sectional study of patients at The University of California at Los Angeles (UCLA) Medical Center who underwent liver transplantation for HCV. ...

  1. THE IMPACT OF THE MELD SCORE ON LIVER TRANSPLANT ALLOCATION AND RESULTS: AN INTEGRATIVE REVIEW.

    Science.gov (United States)

    Moraes, Ana Claudia Oliveira de; Oliveira, Priscilla Caroliny de; Fonseca-Neto, Olival Cirilo Lucena da

    2017-01-01

    Liver transplantation is intended to increase the survival of patients with chronic liver disease in terminal phase, as well as improved quality of life. Since the first transplant until today many changes have occurred in the organ allocation system. To review the literature on the Model for End-stage Liver Disease (MELD) and analyze its correlation with survival after liver transplantation. An integrative literature review in Lilacs, SciELO, and Pubmed in October 2015, was realized. Were included eight studies related to the MELD score and its impact on liver transplant. There was predominance of transplants in male between 45-55 y. The main indications were hepatitis C, hepatocellular carcinoma and alcoholic cirrhosis. The most important factors post-surgery were related to the MELD score, the recipient age, expanded donor criteria and hemotransfusion. The MELD system reduced the death rate in patients waiting for a liver transplant. However, this score by itself is not a good predictor of survival after liver transplantation. O transplante de fígado tem como finalidade o aumento da sobrevida dos pacientes com doença hepática crônica em fase terminal, além de melhora na qualidade de vida. Desde o primeiro transplante até os dias atuais, muitas mudanças ocorreram no sistema de alocação de órgãos. Analisar o conhecimento produzido sobre o Model for End-stage Liver Disease (MELD) e a sua relação com a sobrevida no pós-transplante de fígado. Realizou-se revisão integrativa nas bases de dados Lilacs, SciELO e Pubmed no mês de outubro de 2015. A amostra contou com oito estudos relacionando o escore MELD e o seu impacto no transplante de fígado. Houve predomínio dos transplantes realizados em homens e faixa etária entre 45-55 anos. Como principais indicações tem-se hepatite C, hepatocarcinoma e cirrose por álcool. Os fatores que tiveram maior impacto no pós-operatório estão associados ao alto valor do MELD, idade do receptor, crit

  2. 13C- and 15N-labelled non-biogenic compounds used as stable isotope drugs for human liver function tests

    International Nuclear Information System (INIS)

    Krumbiegel, P.

    1989-01-01

    As a result of liver diseases, the elimination of certain drugs is retarded. After labelling a suitable drug with 13 C, the 13 CO 2 elimination rate serves as a liver function parameter. Current contributions to the 13 CO 2 breath test method are reviewed and related to the 14 CO 2 breath test proposals. In spite of several advantages of 13 C-labelled agents, some dissatisfaction has remained with the tests, especially at using them with infants. It is the necessity of face masks and the uncertainty to consider endogeneous CO 2 contributions diluting the exhaled 13 CO 2 . The problems are avoided if the other molecule site of the drug is labelled which is known to be eliminated via urine. With 15 N as a tracer, a suitable urine test using [ 15 N]-methacetin as agent has been proposed and put into practice. (author)

  3. Relationship between ultrasonic pulse velocity test result and ...

    African Journals Online (AJOL)

    Ultrasonic Pulse Velocity test result showed an inverse relationship (of -0.935) with the crushed concrete compressive strength. Correlation test, multiple regression analysis, graphs and visual inspection were used to analyze the results. The conclusion drawn is that there exists a relationship between UPV test results and ...

  4. Mathematics Placement Test: Typical Results with Unexpected Outcomes

    Science.gov (United States)

    Ingalls, Victoria

    2011-01-01

    Based on the results of a prior case-study analysis of mathematics placement at one university, the mathematics department developed and piloted a mathematics placement test. This article describes the implementation process for a mathematics placement test and further analyzes the test results for the pilot group. As an unexpected result, the…

  5. Non-invasive liver fibrosis score calculated by combination of virtual touch tissue quantification and serum liver functional tests in chronic hepatitis C patients.

    Science.gov (United States)

    Takaki, Shintaro; Kawakami, Yoshiiku; Miyaki, Daisuke; Nakahara, Takashi; Naeshiro, Noriaki; Murakami, Eisuke; Tanaka, Mio; Honda, Yohji; Yokoyama, Satoe; Nagaoki, Yuko; Kawaoka, Tomokazu; Hiramatsu, Akira; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Hyogo, Hideyuki; Aikata, Hiroshi; Takahashi, Shoichi; Arihiro, Koji; Chayama, Kazuaki

    2014-03-01

    Acoustic radiation force impulse (ARFI) technology, involving the shear wave velocity (SWV) with virtual touch tissue quantification (VTTQ), are currently available for the assessment of liver fibrosis, while there is no index derived from the combination of SWV and blood tests. The aim of this study was to develop a new index for assessment of liver fibrosis. The subjects were 176 consecutive patients with hepatitis C (training set [n = 120] and validation set [n = 56]) who underwent liver biopsy in our institution. In the training set, SWV, international normalized ratio (INR) and alanine aminotransferase (ALT) correlated independently and significantly with fibrosis. According to this, we developed the VIA index = -1.282 + 0.965 × SWV + 1.785 INR + 0.00185 ALT. The areas under the receiver-operator curve (AUROC) of the VIA index were 0.838 for the diagnosis of significant fibrosis (≥F2), 0.904 for the severe fibrosis (≥F3) and 0.958 for the cirrhosis (F4) in the training set. While in the validation set, AUROC of the VIA index were 0.917 for F2 or higher, 0.906 for F3 or higher and 1.000 for F4, respectively. AUROC of the VIA index was improved compared to SWV alone, equivalent for VIA for the diagnosis of F2 or higher, and superior to that of FIB-4 index and aspartate aminotransferase-to-platelet ratio index for the diagnosis of F3 or higher and F4. The VIA index is potentially more useful for assessment of liver fibrosis than SWV alone, and easily and accurately measures liver fibrosis stage. © 2013 The Japan Society of Hepatology.

  6. Irradiation effects test series, test IE-5. Test results report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Croucher, D. W.; Yackle, T. R.; Allison, C. M.; Ploger, S. A.

    1978-01-01

    Test IE-5, conducted in the Power Burst Facility at the Idaho National Engineering Laboratory, employed three 0.97-m long pressurized water reactor type fuel rods, fabricated from previously irradiated zircaloy-4 cladding and one similar rod fabricated from unirradiated cladding. The objectives of the test were to evaluate the influence of simulated fission products, cladding irradiation damage, and fuel rod internal pressure on pellet-cladding interaction during a power ramp and on fuel rod behavior during film boiling operation. The four rods were subjected to a preconditioning period, a power ramp to an average fuel rod peak power of 65 kW/m, and steady state operation for one hour at a coolant mass flux of 4880 kg/s-m/sup 2/ for each rod. After a flow reduction to 1800 kg/s-m/sup 2/, film boiling occurred on one rod. Additional flow reductions to 970 kg/s-m/sup 2/ produced film boiling on the three remaining fuel rods. Maximum time in film boiling was 80s. The rod having the highest initial internal pressure (8.3 MPa) failed 10s after the onset of film boiling. A second rod failed about 90s after reactor shutdown. The report contains a description of the experiment, the test conduct, test results, and results from the preliminary postirradiation examination. Calculations using a transient fuel rod behavior code are compared with the test results.

  7. Radiofrequency Ablation for 110 Malignant Liver Tumours: Preliminary Results on Percutaneous and Surgical Approaches

    Directory of Open Access Journals (Sweden)

    J. Wong

    2009-01-01

    Conclusion: RFA is a safe and effective procedure for treating patients with malignant liver tumours. No difference in short term outcomes was observed between percutaneous and surgical approaches. A more prolonged follow-up study is required to assess longer-term outcomes.

  8. Variables predicting elevated portal pressure in alcoholic liver disease. Results of a multivariate analysis

    DEFF Research Database (Denmark)

    Krogsgaard, K; Christensen, E; Gluud, C

    1987-01-01

    In 46 alcoholic patients the association of wedged-to-free hepatic-vein pressure with other variables (clinical, histologic, hemodynamic, and liver function data) was studied by means of multiple regression analysis, taking the wedged-to-free hepatic-vein pressure as the dependent variable. Four ...

  9. Liver transplant associated with paracetamol overdose: Results from the seven-country SALT study

    NARCIS (Netherlands)

    S.E. Gulmez (Sinem Ezgi); D. Larrey (Dominique); G.P. Pageaux; J. Bernuau (Jacques); F. Bissoli (Franco); Y. Horsmans (Yves); D. Thorburn (Douglas); P.A. McCormick (P. Aiden); B.H.Ch. Stricker (Bruno); M. Toussi (Massoud); S. Lignot-Maleyran (Séverine); S. Micon (Sophie); F. Hamoud (Fatima); R. Lassalle (Régis); J. Jové (Jérémy); P. Blin (Patrick); N. Moore (Nicholas)

    2015-01-01

    textabstractAims Acute drug overdose, especially with paracetamol, may cause acute liver failure leading to registration for transplantation (ALFT). Population statistics and between-country differences for ALFT related to overdose have been poorly described. The aim of the present study was to

  10. Noninvasive measurement of liver iron concentration at MRI in children with acute leukemia: initial results

    Energy Technology Data Exchange (ETDEWEB)

    Vag, Tibor; Krumbein, Ines; Reichenbach, Juergen R.; Lopatta, Eric; Stenzel, Martin; Kaiser, Werner A.; Mentzel, Hans-Joachim [Friedrich Schiller University Jena, Institute of Diagnostic and Interventional Radiology, Jena (Germany); Kentouche, Karim; Beck, James [Friedrich Schiller University Jena, Department of Pediatrics, Jena (Germany); Renz, Diane M. [Charite University Medicine Berlin, Department of Radiology, Campus Virchow Clinic, Berlin (Germany)

    2011-08-15

    Routine assessment of body iron load in patients with acute leukemia is usually done by serum ferritin (SF) assay; however, its sensitivity is impaired by different conditions including inflammation and malignancy. To estimate, using MRI, the extent of liver iron overload in children with acute leukemia and receiving blood transfusions, and to examine the association between the degree of hepatic iron overload and clinical parameters including SF and the transfusion iron load (TIL). A total of 25 MRI measurements of the liver were performed in 15 children with acute leukemia (mean age 9.75 years) using gradient-echo sequences. Signal intensity ratios between the liver and the vertebral muscle (L/M ratio) were calculated and compared with SF-levels. TIL was estimated from the cumulative blood volume received, assuming an amount of 200 mg iron per transfused red blood cell unit. Statistical analysis revealed good correlation between the L/M SI ratio and TIL (r = -0.67, P = 0.002, 95% confidence interval CI = -0.83 to -0.34) in patients with acute leukemia as well as between L/M SI ratio and SF (r = -0.76, P = 0.0003, 95% CI = -0.89 to -0.52). SF may reliably reflect liver iron stores as a routine marker in patients suffering from acute leukemia. (orig.)

  11. Enhanced liver fibrosis test in patients with psoriasis, psoriatic arthritis and rheumatoid arthritis : A cross-sectional comparison with procollagen-3 N-terminal peptide (P3NP)

    NARCIS (Netherlands)

    E.A.M. van der Voort (Ella); M. Wakkee (Marlies); P. Veldt-Kok; S. Darwish Murad (Sarwa); T.E.C. Nijsten (Tamar)

    2016-01-01

    markdownabstractBackground: The enhanced liver fibrosis (ELF) test has been introduced to screen, diagnose and/or monitor liver conditions in large groups of patients with liver diseases. It has not been used in inflammatory skin or joint diseases. Objectives: To evaluate the distribution of the

  12. Effect of Aerial Parts Extract of Echinophora Platyloba.L on Liver and Kidney Function Tests in Obese Hypercholesterolaemia Rats

    Directory of Open Access Journals (Sweden)

    H Aqababa

    2016-01-01

    Full Text Available Introduction: Obesity and its complications such as hypertension, fatty liver, type 2 diabetes and kidney failure, can be mentioned as the main life-threating elements. Therefore, this study aimed to evaluate the effect of air parts extract of Echinophora platyloba.L (EP on changes in body weight as well as liver and kidney function tests in hypercholesterolaemia obese rats. Methods: In this experimental study, 40 male Wistar rats were divided in to five groups (n =8 including a control group with normal control diet, control hyperlipidemia group with fatty food diet and hypertriglyceridemia treatment groups which recieved the minimum dose (100 mg/kg, average dose (200 mg/kg maximum dose (300 mg/kg of EP extract via a gavage. At the end of this period (42 days, to measure cholesterol, creatinine, blood urea nitrogen, bilirubin, albumin, total protein, alanine Aminotransferase (ALT and aspartate Aminotransferase (AST and alkaline phosphatase (ALP, the blood samples were collected and the study data were analyzed. Results: Cholesterol, ALT, AST and ALP were reported to significantly decrease (in the minimum and maximum dose groups compared to the control group (P≤0.05. Albumin and total protein in the maximum dose extract group significantly increased compared to the control group (P≤0.05. Moreover, body weight in the group receiving the minimum dose of extract showed a significant decrease compared to the control group (P≤0.05. Conclusion: EP extract, specifically in the minimal doses, in addition to protecting liver, could be recommended as a good candidate in regard with the treatment of blood lipids, and body extra weight.

  13. New test methods for BIPV. Results from IP performance

    International Nuclear Information System (INIS)

    Jol, J.C.; Van Kampen, B.J.M.; De Boer, B.J.; Reil, F.; Geyer, D.

    2009-11-01

    Within the Performance project new test procedures for PV building products and the building performance as a whole when PV is applied in buildings have been drafted. It has resulted in a first draft of new test procedures for PV building products and proposals for tests for novel BIPV technology like thin film. The test proposed are a module breakage test for BIPV products, a fire safety test for BIPV products and a dynamic load test for BIPV products. Furthermore first proposals of how flexible PV modules could be tested in an appropriate way to ensure long time quality and safety of these new products are presented.

  14. Percutaneous imaging-guided treatment of hydatid liver cysts: Do long-term results make it a first choice?

    International Nuclear Information System (INIS)

    Kabaalioglu, Adnan; Ceken, Kagan; Alimoglu, Emel; Apaydin, Ali

    2006-01-01

    Aim: To evaluate the long-term results of percutaneous imaging-guided treatment of hydatid liver cysts. Materials and methods: Sixty patients with 77 hydatid liver cysts underwent percutaneous treatment with ultrasonography (US) or computed tomography (CT) guidance. Absolute alcohol and hypertonic saline were used for sclerosing the cysts after aspiration. Prophylactic albendazole treatment was given before and after the procedures. Follow-up US and CT were obtained periodically, and changes in cyst morphology were recorded. Minimum follow-up period for the patients included in this study was 12 months. Serological correlation was also available for a group of patients. The outcome of the procedures were categorized into five groups based on morphological changes observed by imaging. Results: Procedures were regarded as successful in 80% and unsuccessful in 20% of patients. Failures most often occurred with type III cysts; less than half (39%) of the total type III cysts had a successful outcome. On the other hand, all type I cysts ended up with cure. Anaphylaxis, pneumotorax and severe pain interrupting the procedures were also among the reasons of failure. Conclusion: Percutaneous aspiration, injection and reaspiration (PAIR) of types I and II hydatid liver cysts is effective and safe in the long-term. Surgery should no longer be regarded as the first choice treatment in all hydatid liver cysts but should be reserved for type III and certain active type IV cysts

  15. Percutaneous imaging-guided treatment of hydatid liver cysts: Do long-term results make it a first choice?

    Energy Technology Data Exchange (ETDEWEB)

    Kabaalioglu, Adnan [Department of Radiology, Akdeniz University Hospital, Antalya (Turkey)]. E-mail: adnank@akdeniz.edu.tr; Ceken, Kagan [Department of Radiology, Akdeniz University Hospital, Antalya (Turkey); Alimoglu, Emel [Department of Radiology, Akdeniz University Hospital, Antalya (Turkey); Apaydin, Ali [Department of Radiology, Akdeniz University Hospital, Antalya (Turkey)

    2006-07-15

    Aim: To evaluate the long-term results of percutaneous imaging-guided treatment of hydatid liver cysts. Materials and methods: Sixty patients with 77 hydatid liver cysts underwent percutaneous treatment with ultrasonography (US) or computed tomography (CT) guidance. Absolute alcohol and hypertonic saline were used for sclerosing the cysts after aspiration. Prophylactic albendazole treatment was given before and after the procedures. Follow-up US and CT were obtained periodically, and changes in cyst morphology were recorded. Minimum follow-up period for the patients included in this study was 12 months. Serological correlation was also available for a group of patients. The outcome of the procedures were categorized into five groups based on morphological changes observed by imaging. Results: Procedures were regarded as successful in 80% and unsuccessful in 20% of patients. Failures most often occurred with type III cysts; less than half (39%) of the total type III cysts had a successful outcome. On the other hand, all type I cysts ended up with cure. Anaphylaxis, pneumotorax and severe pain interrupting the procedures were also among the reasons of failure. Conclusion: Percutaneous aspiration, injection and reaspiration (PAIR) of types I and II hydatid liver cysts is effective and safe in the long-term. Surgery should no longer be regarded as the first choice treatment in all hydatid liver cysts but should be reserved for type III and certain active type IV cysts.

  16. Legal provisions governing the acknowledgment of test results

    International Nuclear Information System (INIS)

    Strecker, A.

    1982-01-01

    The legal provisions governing the acknowledgment of test results are most frequently applied by administrative orders (design and qualification approvals or specimen testing and approval) and are thus claimable and voidable in accordance with general administrative law. The acknowledgment of test certificates requires a legal basis. Test results, however, can be acknowledged also by administrative bodies. Recently, the Federal Government began to delegate more of its legal authority in this field to private institutions, allowing test results to be acknowledged and test certificates to be issued by government controlled private institutions. (orig.) [de

  17. A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.

    Science.gov (United States)

    Ducancelle, Alexandra; Leroy, Vincent; Vergniol, Julien; Sturm, Nathalie; Le Bail, Brigitte; Zarski, Jean Pierre; Nguyen Khac, Eric; Salmon, Dominique; de Ledinghen, Victor; Calès, Paul

    2017-08-01

    International guidelines suggest combining a blood test and liver stiffness measurement (LSM) to stage liver fibrosis in chronic hepatitis C (CHC) and non-alcoholic fatty liver disease (NAFLD). Therefore, we compared the accuracies of these tests between the main etiologies of chronic liver diseases. Overall, 1968 patients were included in 5 etiologies: CHC: 698, chronic hepatitis B: 152, human immunodeficiency virus/CHC: 628, NAFLD: 225, and alcoholic liver disease (ALD): 265. Sixteen tests [13 blood tests, LSM (Fibroscan), 2 combined: FibroMeters] were evaluated. References were Metavir staging and CHC etiology. Accuracy was evaluated mainly with the Obuchowski index (OI) and accessorily with area under the receiver operating characteristics (F≥2, F≥3, cirrhosis). OIs in CHC were: FibroMeters: 0.812, FibroMeters: 0.785 to 0.797, Fibrotest: 0.762, CirrhoMeters: 0.756 to 0.771, LSM: 0.754, Hepascore: 0.752, FibroMeter: 0.750, aspartate aminotransferase platelet ratio index: 0.742, Fib-4: 0.741. In other etiologies, most tests had nonsignificant changes in OIs. In NAFLD, CHC-specific tests were more accurate than NAFLD-specific tests. The combined FibroMeters had significantly higher accuracy than their 2 constitutive tests (FibroMeters and LSM) in at least 1 diagnostic target in all etiologies, except in ALD where LSM had the highest OI, and in 3 diagnostic targets (OIs and 2 area under the receiver operating characteristics) in CHC and NAFLD. Some tests developed in CHC outperformed other tests in their specific etiologies. Tests combining blood markers and LSM outperformed single tests, validating recent guidelines and extending them to main etiologies. Noninvasive fibrosis evaluation can thus be simplified in the main etiologies by using a unique test: either LSM alone, especially in ALD, or preferably combined to blood markers.

  18. Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.

    Science.gov (United States)

    Weaver, Richard J; Betts, Catherine; Blomme, Eric A G; Gerets, Helga H J; Gjervig Jensen, Klaus; Hewitt, Philip G; Juhila, Satu; Labbe, Gilles; Liguori, Michael J; Mesens, Natalie; Ogese, Monday O; Persson, Mikael; Snoeys, Jan; Stevens, James L; Walker, Tracy; Park, B Kevin

    2017-07-01

    The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue for drug development. Areas Covered: The current state of the science, understanding and application of test systems in use for the detection of drug-induced cytotoxicity, mitochondrial toxicity, cholestasis and inflammation is summarized. The test systems highlighted herein cover mostly in vitro and some in vivo models and endpoint measurements used in the assessment of small molecule toxic liabilities. Opportunities for research efforts in areas necessitating the development of specific tests and improved mechanistic understanding are highlighted. Expert Opinion: Use of in vitro test systems for safety optimization will remain a core activity in drug discovery. Substantial inroads have been made with a number of assays established for human Drug-induced Liver Injury. There nevertheless remain significant gaps with a need for improved in vitro tools and novel tests to address specific mechanisms of human Drug-Induced Liver Injury. Progress in these areas will necessitate not only models fit for application, but also mechanistic understanding of how chemical insult on the liver occurs in order to identify translational and quantifiable readouts for decision-making.

  19. 42 CFR 493.1281 - Standard: Comparison of test results.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Comparison of test results. 493.1281 Section 493.1281 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Testing Analytic Systems § 493.1281 Standard: Comparison of test results. (a) If a laboratory performs the...

  20. Irradiation Effects Test Series: Test IE-3. Test results report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, L. C.; Allison, C. M.; Croucher, D. W.; Ploger, S. A.

    1977-10-01

    The objectives of the test reported were to: (a) determine the behavior of irradiated fuel rods subjected to a rapid power increase during which the possibility of a pellet-cladding mechanical interaction failure is enhanced and (b) determine the behavior of these fuel rods during film boiling following this rapid power increase. Test IE-3 used four 0.97-m long pressurized water reactor type fuel rods fabricated from previously irradiated fuel. The fuel rods were subjected to a preconditioning period, followed by a power ramp to 69 kW/m at a coolant mass flux of 4920 kg/s-m/sup 2/. After a flow reduction to 2120 kg/s-m/sup 2/, film boiling occurred on the fuel rods. One rod failed approximately 45 seconds after the reactor was shut down as a result of cladding embrittlement due to extensive cladding oxidation. Data are presented on the behavior of these irradiated fuel rods during steady-state operation, the power ramp, and film boiling operation. The effects of a power ramp and power ramp rates on pellet-cladding interaction are discussed. Test data are compared with FRAP-T3 computer model calculations and data from a previous Irradiation Effects test in which four irradiated fuel rods of a similar design were tested. Test IE-3 results indicate that the irradiated state of the fuel rods did not significantly affect fuel rod behavior during normal, abnormal (power ramp of 20 kW/m per minute), and accident (film boiling) conditions.

  1. Results from the 2013 drug and alcohol testing survey.

    Science.gov (United States)

    2015-12-01

    This report summarizes the results of the 2013 Federal Motor Carrier Safety Administration (FMCSA) Drug and Alcohol Testing Survey. This annual survey measures the percentage of drivers with commercial drivers licenses (CDLs) that test positive fo...

  2. Results from the 2008 Drug and Alcohol Testing Survey

    Science.gov (United States)

    2010-01-01

    This report summarizes the results of the 2008 Federal Motor Carrier Safety Administration Drug and Alcohol Testing Survey. This annual survey measures the percentage of drivers with commercial drivers licenses who test positive for controlled sub...

  3. Experimental test results of multi-channel test rig of T1 test section, 5

    International Nuclear Information System (INIS)

    Hino, Ryutaro; Takase, Kazuyuki; Miyamoto, Yoshiaki

    1990-09-01

    Channel blockage test on a fuel column of the high temperature engineering test reactor (HTTR) has been performed under the helium gas atmosphere at a high temperature and a high pressure in order to obtain safety data on flow rate and temperature distributions in the fuel column with the multi-channel test rig of the fuel stack test section (T 1 ) in HENDEL. In the test, one of 12 fuel channels was blockaded to 90% of flow area at the channel inlet. Experimental results showed that the helium gas flow rate in the blockaded channel was 28%∼33% lower than the average flow rate for Reynolds number from 2300 to 14000 in isothermal flow. When simulated fuel rods were heated, the flow rate in the blockaded channel did not decrease down in comparison with the isothermal flow. This is due to that the heat generated in the fuel rods conducts to the other fuel channels in graphite fuel blocks, so that accelerated pressure losses in the fuel channels change with helium gas temperatures. (author)

  4. Biostatistical analysis of treatment results of bacterial liver abscesses using minimally invasive techniques and open surgery

    Directory of Open Access Journals (Sweden)

    Кipshidze A.A.

    2013-12-01

    Full Text Available Today bacterial abscesses remain one of the most difficult complications in surgical hepatology, both traditional and minimally invasive methods of their treatment are used. Bio-statistical analysis is used due to the fact that strong evidences are required for the effectiveness of one or another method of surgical intervention. The estimation of statistical significance of differences between the control and the main group of patients with liver abscesses is given in this paper. Depending on the treatment method patients were divided into two groups: 1 - minimally invasive surgery (89 cases; 2 – laporatomy surgery (74 patients. Data compa¬ri¬son was performed by means of Stjudent's criterion. The effectiveness of method of abscesses drainage using inter¬ventional sonography, outer nazobiliar drainage with reorganization of ductal liver system and abscess cavity with the help of modern antiseptics was considered. The percentage of cured patients was also estimated.

  5. Integrated leak rate test results of JOYO reactor containment vessel

    International Nuclear Information System (INIS)

    Tamura, M.; Endo, J.

    1982-02-01

    Integrated leak rate tests of JOYO after the reactor coolant system had been filled with sodium have been performed two times since 1978 (February 1978 and December 1979). The tests were conducted with the in-containment sodium systems, primary argon cover gas system and air conditioning systems operating. Both the absolute pressure method and the reference chamber method were employed during the test. The results of both tests confirmed the functioning of the containment vessel, and leak rate limits were satisfied. In Addition, the adequancy of the test instrumentation system and the test method was demonstrated. Finally the plant conditions required to maintain reasonable accuracy for the leak rate testing of LMFBR were established. In this paper, the test conditions and the test results are described. (author)

  6. Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy.

    Science.gov (United States)

    Brusilow, Saul W; Cooper, Arthur J L

    2011-11-01

    Hyperammonemia is a major contributing factor to the encephalopathy associated with liver disease. It is now generally accepted that hyperammonemia leads to toxic levels of glutamine in astrocytes. However, the mechanism by which excessive glutamine is toxic to astrocytes is controversial. Nevertheless, there is strong evidence that glutamine-induced osmotic swelling, especially in acute liver failure, is a contributing factor: the osmotic gliopathy theory. The object of the current communication is to present evidence for the osmotic gliopathy theory in a hyperammonemic patient who overdosed on acetaminophen. Case report. Johns Hopkins Hospital. A 22-yr-old woman who, 36 hrs before admission, ingested 15 g acetaminophen was admitted to the Johns Hopkins Hospital. She was treated with N-acetylcysteine. Physical examination was unremarkable; her mental status was within normal limits and remained so until approximately 72 hrs after ingestion when she became confused, irritable, and agitated. She was intubated, ventilated, and placed on lactulose. Shortly thereafter, she was noncommunicative, unresponsive to painful stimuli, and exhibited decerebrate posturing. A clinical diagnosis of cerebral edema and increased intracranial pressure was made. She improved very slowly until 180 hrs after ingestion when she moved all extremities. She woke up shortly thereafter. Despite the fact that hyperammonemia is a major contributing factor to the encephalopathy observed in acute liver failure, the patient's plasma ammonia peaked when she exhibited no obvious neurologic deficit. Thereafter, her plasma ammonia decreased precipitously in parallel with a worsening neurologic status. She was deeply encephalopathic during a period when her liver function and plasma ammonia had normalized. Plasma glutamine levels in this patient were high but began to normalize several hours after plasma ammonia had returned to normal. The patient only started to recover as her plasma glutamine began

  7. Hepatotoxicity after liver irradiation in children and adolescents. Results from the RiSK

    Energy Technology Data Exchange (ETDEWEB)

    Roesler, Pascal; Christiansen, Hans [Medical School Hannover, Department of Radiotherapy and Special Oncology, Hannover (Germany); Kortmann, Rolf-Dieter [University of Leipzig, Department of Radiotherapy, Leipzig (Germany); Martini, Carmen [University Hospital of Freiburg, Department of Radiotherapy, Freiburg im Breisgau (Germany); Matuschek, Christiane [Heinrich-Heine University of Duesseldorf, Department of Radiotherapy, Medical Faculty, Duesseldorf (Germany); Meyer, Frank [Hospital Augsburg, Department of Radiotherapy, Augsburg (Germany); Ruebe, Christian [University Hospital of Homburg/Saar, Department of Radiotherapy, Homburg/Saar (Germany); Langer, Thorsten [University Hospital of Schleswig-Holstein, Department of Pediatrics, Pediatric Oncology, Campus Luebeck (Germany); Koch, Raphael [University of Muenster, Institute of Biostatistics and Clinical Research, Muenster (Germany); Eich, Hans Theodor; Willich, Normann [University Hospital of Muenster, Department of Radiotherapy, Muenster (Germany); Steinmann, Diana [Medical School Hannover, Department of Radiotherapy and Special Oncology, Hannover (Germany); University Hospital of Muenster, Department of Radiotherapy, Muenster (Germany)

    2015-05-01

    The aim of this study was to evaluate acute and late radiotherapy-associated hepatotoxicity in consideration of dose-volume effects and liver function in childhood and adolescence. Since 2001, irradiated children and adolescents in Germany have been prospectively documented in the ''Register of Treatment-Associated Late Effects After Radiotherapy of Malignant Diseases in Childhood and Adolescence (RiSK)'' using standardized forms. Toxicity was graded according to the Radiation Therapy Oncology Group (RTOG) criteria. Until April 2012, 1,392 children and adolescents from 62 radiotherapy centers were recruited. In all, 216 patients underwent irradiation of the liver (median age 9 years, range 1-18 years, 70 patients with total-body irradiation, TBI). For 75 % of patients without TBI, information on acute toxicity of the liver was available: 24 patients had acute toxicity of grade 1-4 (grade 1, 2, and 4, in 20, 3, and 1 patient, respectively), including five patients receiving simultaneous hepatotoxic chemotherapy. Information on late toxicity was documented in 465 forms from 216 patients, with a median follow-up of 2 years. A maximum grade of toxicity of ≥ 0 occurred in 18 patients over time (with grade 1, 2, and 3 toxicity occurring in 15, 2, and 1 patient, respectively), including three patients (17 %) with TBI. One of them received simultaneous hepatotoxic chemotherapy. In multivariable analysis, volume-dose correlations showed no statistically noticeable effect on acute or chronic toxicity. Only low hepatotoxicity developed in children after irradiation of various abdominal and thoracic tumors. Due to the low radiation doses to the liver (median liver dose = 5 Gy) and the low toxicities that were consecutively observed, dose-volume curves for liver toxicity could not be established. These findings reflect the cautious attitude of radiation oncologists in terms of attributable liver doses in the treatment of the investigated tumor entities. It

  8. Assessment of the quality of test results from selected civil engineering material testing laboratories in Tanzania

    CSIR Research Space (South Africa)

    Mbawala, SJ

    2017-12-01

    Full Text Available Civil and geotechnical engineering material testing laboratories are expected to produce accurate and reliable test results. However, the ability of laboratories to produce accurate and reliable test results depends on many factors, among others...

  9. Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro.

    Science.gov (United States)

    Maschmeyer, Ilka; Hasenberg, Tobias; Jaenicke, Annika; Lindner, Marcus; Lorenz, Alexandra Katharina; Zech, Julie; Garbe, Leif-Alexander; Sonntag, Frank; Hayden, Patrick; Ayehunie, Seyoum; Lauster, Roland; Marx, Uwe; Materne, Eva-Maria

    2015-09-01

    Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives. Relevant international regulations, such as OECD and ICH guidelines, demand long-term testing and oral, dermal, inhalation, and systemic exposure routes for such evaluations. So-called "human-on-a-chip" concepts are aiming to replace respective animals and humans in substance evaluation with miniaturized functional human organisms. The major technical hurdle toward success in this field is the life-like combination of human barrier organ models, such as intestine, lung or skin, with parenchymal organ equivalents, such as liver, at the smallest biologically acceptable scale. Here, we report on a reproducible homeostatic long-term co-culture of human liver equivalents with either a reconstructed human intestinal barrier model or a human skin biopsy applying a microphysiological system. We used a multi-organ chip (MOC) platform, which provides pulsatile fluid flow within physiological ranges at low media-to-tissue ratios. The MOC supports submerse cultivation of an intact intestinal barrier model and an air-liquid interface for the skin model during their co-culture with the liver equivalents respectively at (1)/100.000 the scale of their human counterparts in vivo. To increase the degree of organismal emulation, microfluidic channels of the liver-skin co-culture could be successfully covered with human endothelial cells, thus mimicking human vasculature, for the first time. Finally, exposure routes emulating oral and systemic administration in humans have been qualified by applying a repeated dose administration of a model substance - troglitazone - to the chip-based co-cultures. Copyright © 2015. Published by Elsevier B.V.

  10. Melter operation results in chemical test at Rokkasho Reprocessing Plant

    International Nuclear Information System (INIS)

    Kanehira, Norio; Yoshioka, Masahiro; Muramoto, Hitoshi; Oba, Takaaki; Takahashi, Yuji

    2005-01-01

    Chemical Test of the glass melter system of the Vitrification Facility at Rokkasho Reprocessing Plant (RRP) was performed. In this test, basic performance of heating-up of the melter, melting glass, pouring glass was confirmed using simulated materials. Through these tests and operation of all modes, good results were gained, and training of operators was completed. (author)

  11. The Dornier 328 Acoustic Test Cell (ATC) for interior noise tests and selected test results

    Science.gov (United States)

    Hackstein, H. Josef; Borchers, Ingo U.; Renger, Klaus; Vogt, Konrad

    1992-01-01

    To perform acoustic studies for achieving low noise levels for the Dornier 328, an acoustic test cell (ATC) of the Dornier 328 has been built. The ATC consists of a fuselage section, a realistic fuselage suspension system, and three exterior noise simulation rings. A complex digital 60 channel computer/amplifier noise generation system as well as multichannel digital data acquisition and evaluation system have been used. The noise control tests started with vibration measurements for supporting acoustic data interpretation. In addition, experiments have been carried out on dynamic vibration absorbers, the most important passive noise reduction measure for low frequency propeller noise. The design and arrangement of the current ATC are presented. Furthermore, exterior noise simulation as well as data acquisition are explained. The most promising results show noise reduction due to synchrophasing and dynamic vibration absorbers.

  12. Production Facility Prototype Blower 1000 Hour Test Results II

    Energy Technology Data Exchange (ETDEWEB)

    Wass, Alexander Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dalmas, Dale Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Frank Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-01-08

    Long duration tests of the Aerzen GM 12.4 roots style blower in a closed loop configuration provides valuable data and lessons learned for long-term operation at the Mo-99 production facility. The blower was operated in a closed loop configuration with the flow conditions anticipated in plant operation with a Mo-100 target inline. The additional thermal energy generated from beam heating of the Mo-100 disks were not included in these tests. Five 1000 hour tests have been completed since the first test was performed in January of 2016. All five 1000 hour tests have proven successful in exposing preventable issues related to oil and helium leaks. All blower tests to this date have resulted in stable blower performance and consistency. A summary of the results for each test, including a review of the first and second tests, are included in this report.

  13. Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test

    Directory of Open Access Journals (Sweden)

    Yi-Chou Hou

    2014-01-01

    Full Text Available Aim. The galactose single-point (GSP test assesses functioning liver mass by measuring the galactose concentration in the blood 1 hour after its administration. The purpose of this study was to investigate the impact of hemodialysis (HD on short-term and long-term liver function by use of GSP test. Methods. Seventy-four patients on maintenance HD (46 males and 28 females, 60.38 ± 11.86 years with a mean time on HD of 60.77 ± 48.31 months were studied. The GSP values were compared in two groups: (1 before and after single session HD, and (2 after one year of maintenance HD. Results. Among the 74 HD patient, only the post-HD Cr levels and years on dialysis were significantly correlated with GSP values (r=0.280, P<0.05 and r=-0.240, P<0.05, resp.. 14 of 74 patients were selected for GSP evaluation before and after a single HD session, and the hepatic clearance of galactose was similar (pre-HD 410 ± 254 g/mL, post-HD 439 ± 298 g/mL, P=0.49. GSP values decreased from 420.20 ± 175.26 g/mL to 383.40 ± 153.97 g/mL after 1 year maintenance HD in other 15 patients (mean difference: 19.00 ± 37.66 g/mL, P<0.05. Conclusions. Patients on maintenance HD for several years may experience improvement of their liver function. However, a single HD session does not affect liver function significantly as assessed by the GSP test. Since the metabolism of galactose is dependent on liver blood flow and hepatic functional mass, further studies are needed.

  14. Results and Analysis from Space Suit Joint Torque Testing

    Science.gov (United States)

    Matty, Jennifer

    2010-01-01

    This joint mobility KC lecture included information from two papers, "A Method for and Issues Associated with the Determination of Space Suit Joint Requirements" and "Results and Analysis from Space Suit Joint Torque Testing," as presented for the International Conference on Environmental Systems in 2009 and 2010, respectively. The first paper discusses historical joint torque testing methodologies and approaches that were tested in 2008 and 2009. The second paper discusses the testing that was completed in 2009 and 2010.

  15. Hawaiian Electric Advanced Inverter Test Plan - Result Summary

    Energy Technology Data Exchange (ETDEWEB)

    Hoke, Anderson; Nelson, Austin; Prabakar, Kumaraguru; Nagarajan, Adarsh

    2016-10-14

    This presentation is intended to share the results of lab testing of five PV inverters with the Hawaiian Electric Companies and other stakeholders and interested parties. The tests included baseline testing of advanced inverter grid support functions, as well as distribution circuit-level tests to examine the impact of the PV inverters on simulated distribution feeders using power hardware-in-the-loop (PHIL) techniques. hardware-in-the-loop (PHIL) techniques.

  16. Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.

    Science.gov (United States)

    Krawczyk, Marcin; Bantel, Heike; Rau, Monika; Schattenberg, Jörn M; Grünhage, Frank; Pathil, Anita; Demir, Münevver; Kluwe, Johannes; Boettler, Tobias; Weber, Susanne N; Geier, Andreas; Lammert, Frank

    2018-05-01

    Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrome. Variants PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 rs641738 are associated with higher liver fat contents. Here we analyzed 63 biopsied non-obese, non-diabetic patients with NAFLD (39 men, age: 20-72 years) recruited within the German NAFLD CSG program. The frequencies of the PNPLA3, TM6SF2 and MBOAT7 polymorphisms were compared with the remaining patients in the NAFLD CSG cohort and with a control population (n = 174). Serum CK18-M30 was measured by ELISA. In non-obese NAFLD patients, the frequency of the PNPLA3 p.I148M allele (74.6%), but not of the TM6SF2 or MBOAT7 polymorphisms, was significantly (P < 0.05) higher as compared to the other patients in the NAFLD CSG cohort (54.9%) or controls (40.2%). The presence of the minor PNPLA3 p.I148M risk allele increased the risk of developing NAFLD (OR = 3.29, P < 0.001) and was associated with higher steatosis, fibrosis, and serum CK18-M30 levels (all P < 0.05). According to the population attributable fraction (PAF), 49.8% of NAFLD cases could be eliminated if the PNPLA3 mutation was absent. The MBOAT7 polymorphism was more frequent (P = 0.019) in patients with severe hepatic steatosis. In conclusion, PNPLA3, and to a lesser extent, MBOAT7 variants are associated with NAFLD risk and modulate liver injury in non-obese patients without diabetes.

  17. Radioembolisation for liver metastases: results from a prospective 151 patient multi-institutional phase II study.

    Science.gov (United States)

    Benson, Al B; Geschwind, Jean-Francois; Mulcahy, Mary F; Rilling, William; Siskin, Gary; Wiseman, Greg; Cunningham, James; Houghton, Bonny; Ross, Mason; Memon, Khairuddin; Andrews, James; Fleming, Chad J; Herman, Joseph; Nimeiri, Halla; Lewandowski, Robert J; Salem, Riad

    2013-10-01

    To investigate the safety, response rate, progression-free and overall survival of patients with liver metastases treated with (90)Y (glass) radioembolisation in a prospective, multicenter phase II study. 151 patients with liver metastases (colorectal n=61, neuroendocrine n=43 and other tumour types n=47) refractory to standard of care therapies were enrolled in this prospective, multicenter, phase II study under an investigational device exemption. Clinical/laboratory/imaging follow-up were obtained at 30 days followed by 3-month intervals for 1 year and every 6 months thereafter. The primary end-point was progression-free survival (PFS); secondary end-points included safety, hepatic progression-free survival (HPFS), response rate and overall survival. Median age was 66 (range 25-88). Grade 3/4 adverse events included pain (12.8%), elevated alkaline phospatase (8.1%), hyperbilirubinemia (5.3%), lymphopaenia (4.1%), ascites (3.4%) and vomiting (3.4%). Treatment parameters including dose delivery were reproducible among centers. Disease control rates were 59%, 93% and 63% for colorectal, neuroendocrine and other primaries, respectively. Median PFS was 2.9 and 2.8 months for colorectal and other primaries, respectively. PFS was not achieved in the neuroendocrine group. Median survival from (90)Y treatment was 8.8 months for colorectal and 10.4 months for other primaries. Median survival for neuroendocrine patients has not been reached. Patients with liver metastases can be safely treated with (90)Y microspheres. This study is the first to demonstrate technical and dose reproducibility of (90)Y glass microspheres between centers in a prospective setting. Based on these promising data, three international, multicenter, randomised phase III studies in colorectal and hepatocellular carcinoma have been initiated. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Respiratory gating based on internal electromagnetic motion monitoring during stereotactic liver radiation therapy: First results.

    Science.gov (United States)

    Poulsen, Per Rugaard; Worm, Esben Schjødt; Hansen, Rune; Larsen, Lars Peter; Grau, Cai; Høyer, Morten

    2015-01-01

    Intrafraction motion may compromise the target dose in stereotactic body radiation therapy (SBRT) of tumors in the liver. Respiratory gating can improve the treatment delivery, but gating based on an external surrogate signal may be inaccurate. This is the first paper reporting on respiratory gating based on internal electromagnetic monitoring during liver SBRT. Two patients with solitary liver metastases were treated with respiratory-gated SBRT guided by three implanted electromagnetic transponders. The treatment was delivered in end-exhale with beam-on when the centroid of the three transponders deviated less than 3 mm [left-right (LR) and anterior-posterior (AP) directions] and 4mm [cranio-caudal (CC)] from the planned position. For each treatment fraction, log files were used to determine the transponder motion during beam-on in the actual gated treatments and in simulated treatments without gating. The motion was used to reconstruct the dose to the clinical target volume (CTV) with and without gating. The reduction in D95 (minimum dose to 95% of the CTV) relative to the plan was calculated for both treatment courses. With gating the maximum course mean (standard deviation) geometrical error in any direction was 1.2 mm (1.8 mm). Without gating the course mean error would mainly increase for Patient 1 [to -2.8 mm (1.6 mm) (LR), 7.1 mm (5.8 mm) (CC), -2.6 mm (2.8mm) (AP)] due to a large systematic cranial baseline drift at each fraction. The errors without gating increased only slightly for Patient 2. The reduction in CTV D95 was 0.5% (gating) and 12.1% (non-gating) for Patient 1 and 0.3% (gating) and 1.7% (non-gating) for Patient 2. The mean duty cycle was 55%. Respiratory gating based on internal electromagnetic motion monitoring was performed for two liver SBRT patients. The gating added robustness to the dose delivery and ensured a high CTV dose even in the presence of large intrafraction motion.

  19. Evaluation of LLTR series II test A-7 results

    International Nuclear Information System (INIS)

    Knittle, D.E.; Amos, J.C.; Yang, T.M.

    1981-09-01

    This report evaluates the test A-7 data and assesses the capability of the analytical methodology (as a result of Series I program) to predict the thermal/hydraulic phenomena associated with a large SWR event occurring after the sodium system pressure has increased to near the rupture disc burst pressure due to a smaller size leak event. Evaluation of intertest examination data to determine the extent of test article damage resulting from test A-7 is also included

  20. Test beam results from the D0 end electromagnetic calorimeter

    International Nuclear Information System (INIS)

    Roe, N.A.

    1991-11-01

    Test beam results are presented for the DO end electromagnetic calorimeter. Data were taken with electrons and pions ranging in energy from 5 GeV to 150 GeV. Results from the analysis of the test beam data are presented on energy resolution and linearity, stability and uniformity of response, position resolution and electron-pion separation

  1. Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia.

    Directory of Open Access Journals (Sweden)

    Daniel Holl

    Full Text Available BACKGROUND: The transcription factor Tcfap2c has been demonstrated to be essential for various processes during mammalian development. It has been found to be upregulated in various undifferentiated tumors and is implicated with poor prognosis. Tcfap2c is reported to impinge on cellular proliferation, differentiation and apoptosis. However, the physiological consequences of Tcfap2c-expression remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Therefore we established a gain of function model to analyze the role of Tcfap2c in development and disease. Induction of the transgene led to robust expression in all tissues (except brain and testis and lead to rapid mortality within 3-7 days. In the liver cellular proliferation and apoptosis was detected. Accumulation of microvesicular lipid droplets and breakdown of major hepatic metabolism pathways resulted in steatosis. Serum analysis showed a dramatic increase of enzymes indicative for hepatic failure. After induction of Tcfap2c we identified a set of 447 common genes, which are deregulated in both liver and primary hepatocyte culture. Further analysis showed a prominent repression of the cytochrome p450 system, PPARA, Lipin1 and Lipin2. These data indicate that in the liver Tcfap2c represses pathways, which are responsible for fatty acid metabolism. In the intestine, Tcfap2c expression resulted in expansion of Sox9 positive and proliferative active epithelial progenitor cells resulting in dysplastic growth of mucosal crypt cells and loss of differentiated mucosa. CONCLUSIONS: The transgenic mice show that ectopic expression of Tcfap2c is not tolerated. Due to the phenotype observed, iTcfap2c-mice represent a model system to study liver failure. In intestine, Tcfap2c induced cellular hyperplasia and suppressed terminal differentiation indicating that Tcfap2c serves as a repressor of differentiation and inducer of proliferation. This might be achieved by the Tcfap2c mediated activation of Sox9

  2. Assessment of liver steatosis in chicken by using acoustic radiation force impulse imaging: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Guzman Aroca, Florentina; Serrano, Laura; Berna-Serna, Juan D.; Reus, Manuel [Virgen de la Arrixaca University Hospital, Department of Radiology, El Palmar, Murcia (Spain); Ayala, Ignacio [University of Murcia, Department of Animal Medicine and Surgery, Murcia (Spain); Castell, Maria T. [University of Murcia, Department of Cell Biology, Murcia (Spain); Garcia-Perez, Bartolome [Virgen de la Arrixaca University Hospital, Internal Medicine Service, El Palmar, Murcia (Spain)

    2010-10-15

    To evaluate acoustic radiation force impulse (ARFI) imaging as a non-invasive tool for quantification of the grades of liver steatosis in chickens. We used two different diets: a standard diet (SD group) and a hyperlipidaemic diet (HD group). The ARFI technique was performed in all the animals in the right hepatic lobe and shear wave velocity (SWV) was measured and expressed in metres per second (m/s). Plasma lipid levels were analysed. Steatosis was quantified by using semiquantitative analysis. Statistical analysis was used and Pearson's correlation coefficient was calculated. Mean SWV was 0.94 {+-} 0.16 m/s (range 0.8-1.3 m/s) in the SD group and 1.91 {+-} 0.25 m/s (range 1.3-2.2 m/s) in the HD group (p < 0.001). The lowest SWVs ({<=}1.3 m/s) corresponded to the chickens in the SD group, with 100% of the animals returning a score of 0, whereas the range of SWV in the HD group chickens was between 1.6 and 2.2 m/s. A substantial correlation was observed between SWVs with histological semiquantitative analysis of steatosis (r = 0.85, p < 0.001). ARFI imaging is a non-invasive diagnostic tool that allows discrimination between the grades of liver steatosis in chickens. (orig.)

  3. Assessment of liver steatosis in chicken by using acoustic radiation force impulse imaging: preliminary results

    International Nuclear Information System (INIS)

    Guzman Aroca, Florentina; Serrano, Laura; Berna-Serna, Juan D.; Reus, Manuel; Ayala, Ignacio; Castell, Maria T.; Garcia-Perez, Bartolome

    2010-01-01

    To evaluate acoustic radiation force impulse (ARFI) imaging as a non-invasive tool for quantification of the grades of liver steatosis in chickens. We used two different diets: a standard diet (SD group) and a hyperlipidaemic diet (HD group). The ARFI technique was performed in all the animals in the right hepatic lobe and shear wave velocity (SWV) was measured and expressed in metres per second (m/s). Plasma lipid levels were analysed. Steatosis was quantified by using semiquantitative analysis. Statistical analysis was used and Pearson's correlation coefficient was calculated. Mean SWV was 0.94 ± 0.16 m/s (range 0.8-1.3 m/s) in the SD group and 1.91 ± 0.25 m/s (range 1.3-2.2 m/s) in the HD group (p < 0.001). The lowest SWVs (≤1.3 m/s) corresponded to the chickens in the SD group, with 100% of the animals returning a score of 0, whereas the range of SWV in the HD group chickens was between 1.6 and 2.2 m/s. A substantial correlation was observed between SWVs with histological semiquantitative analysis of steatosis (r = 0.85, p < 0.001). ARFI imaging is a non-invasive diagnostic tool that allows discrimination between the grades of liver steatosis in chickens. (orig.)

  4. Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results

    International Nuclear Information System (INIS)

    Kettenbach, Joachim; Stadler, Alfred; Katzler, Isabella v.; Schernthaner, Ruediger; Blum, Melanie; Lammer, Johannes; Rand, Thomas

    2008-01-01

    Transarterial chemoembolization (TACE) involves the emulsification of a chemotherapeutic agent in a viscous drug carrier, delivered intra-arterially to liver tumor for maximum effect. TACE reduces arterial inflow, diminishes washout of the chemotherapeutic agent, and decreases systemic exposure. Despite evidence of some clinical success with TACE, a new type of microspheres with drug-eluting capabilities may offer a precisely controlled and sustainable release of the chemotherapeutic agent into the tumor bed. In animal trials tumor necrosis (approaching 100%) was greatest at 7 days, with significantly lower plasma concentrations of doxorubicin than in control animals treated with doxorubicin intra-arterially. Clinically, drug-eluting microspheres loaded with doxorubicin, either at 75 mg/m 2 or at a fixed dose of 150 mg, were used recently and no severe disorders of the hepatic function were observed postprocedure, while a substantial reduction of the fetoprotein levels occurred. An interim analysis of the first 15 patients from the Hong Kong group at 3 months showed an objective response rate of 61.54% and 53.84% according to EASL criteria and RECIST criteria, respectively, and a survival rate of 93.3%. In this paper we present how to use microspheres loaded with doxorubicin and review their clinical value and preliminary performance for treatment of unresectable liver cancer

  5. Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study.

    Science.gov (United States)

    Ng, Vicky L; Sorensen, Lisa G; Alonso, Estella M; Fredericks, Emily M; Ye, Wen; Moore, Jeff; Karpen, Saul J; Shneider, Benjamin L; Molleston, Jean P; Bezerra, Jorge A; Murray, Karen F; Loomes, Kathleen M; Rosenthal, Philip; Squires, Robert H; Wang, Kasper; Arnon, Ronen; Schwarz, Kathleen B; Turmelle, Yumirle P; Haber, Barbara H; Sherker, Averell H; Magee, John C; Sokol, Ronald J

    2018-05-01

    To assess neurodevelopmental outcomes among participants with biliary atresia with their native liver at ages 12 months (group 1) and 24 months (group 2), and to evaluate variables predictive of neurodevelopmental impairment. Participants enrolled in a prospective, longitudinal, multicenter study underwent neurodevelopmental testing with either the Bayley Scales of Infant Development, 2nd edition, or Bayley Scales of Infant and Toddler Development, 3rd edition. Scores (normative mean = 100 ± 15) were categorized as ≥100, 85-99, and Development, 2nd edition, or Bayley Scales of Infant and Toddler Development, 3rd edition, scales) was analyzed using logistic regression. There were 148 children who completed 217 Bayley Scales of Infant and Toddler Development, 3rd edition, examinations (group 1, n = 132; group 2, n = 85). Neurodevelopmental score distributions significantly shifted downward compared with test norms at 1 and 2 years of age. Multivariate analysis identified ascites (OR, 3.17; P = .01) and low length z-scores at time of testing (OR, 0.70; P cognitive/language impairment at 1 year of age. An unsuccessful hepatoportoenterostomy was predictive of both physical/motor (OR, 4.88; P cognitive/language impairment (OR, 4.76; P = .02) at 2 years of age. Participants with biliary atresia surviving with native livers after hepatoportoenterostomy are at increased risk for neurodevelopmental delays at 12 and 24 months of age. Those with unsuccessful hepatoportoenterostomy are >4 times more likely to have neurodevelopmental impairment compared with those with successful hepatoportoenterostomy. Growth delays and/or complications indicating advanced liver disease should alert clinicians to the risk for neurodevelopmental delays, and expedite appropriate interventions. Clinicaltrials.gov: NCT00061828 and NCT00294684. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Results of Detailed Hydrologic Characterization Tests - Fiscal Year 2000

    International Nuclear Information System (INIS)

    Spane, Frank A; Thorne, Paul D; Newcomer, Darrell R

    2001-01-01

    This report provides the results of detailed hydrologic characterization tests conducted within eleven Hanford Site wells during fiscal year 2000. Detailed characterization tests performed included groundwater-flow characterization; barometric response evaluation; slug tests; single-well tracer tests; constant-rate pumping tests; and in-well, vertical flow tests. Hydraulic property estimates obtained from the detailed hydrologic tests include transmissivity; hydraulic conductivity; specific yield; effective porosity; in-well, lateral flow velocity; aquifer-flow velocity; vertical distribution of hydraulic conductivity (within the well-screen section); and in-well, vertical flow velocity. In addition, local groundwater-flow characteristics (i.e., hydraulic gradient and flow direction) were determined for four sites where detailed well testing was performed

  7. Early results of gate valve flow interruption blowdown tests

    International Nuclear Information System (INIS)

    DeWall, K.G.

    1988-01-01

    The preliminary results of the USNRC/INEL high-energy BWR line break flow interruption testing are presented. Two representative nuclear valve assemblies were cycled under design basis Reactor Water Cleanup pipe break conditions to provide input for the technical basis for resolving the Nuclear Regulatory Commission's Generic Issue 87. The effects of the blowdown hydraulic loadings on valve operability, especially valve closure stem forces, were studied. The blowdown tests showed that, given enough thrust, typical gate valves will close against the high flow resulting from a line break. The tests also showed that proper operator sizing depends on the correct identification of values for the sizing equation. Evidence exists that values used in the past may not be conservative for all valve applications. The tests showed that improper operator lock ring installation following test or maintenance can invalidate in-situ test results and prevent the valve from performing its design function. 2 refs., 12 figs., 2 tabs

  8. [Liver transplantation--indications, surgical technique, results--the analysis of a clinical series of 200 cases].

    Science.gov (United States)

    Popescu, I; Ionescu, M; Braşoveanu, V; Hrehoreţ, D; Matei, E; Dorobantu, B; Zamfir, R; Alexandrescu, S; Grigorie, M; Tulbure, D; Popa, L; Ungureanu, M; Tomescu, D; Droc, G; Popescu, H; Cristea, A; Gheorghe, L; Iacob, S; Gheorghe, C; Boroş, M; Lupescu, I; Vlad, L; Herlea, V; Croitoru, M; Platon, P; Alloub, A

    2010-01-01

    Initially considered experimental, liver transplantation (LT) has become the treatment of choice for the patients with end-stage liver diseases. Between April 2000 and October 2009, 200 LTs (10 reLTs) were performed in 190 patients, this study being retrospective. There were transplanted 110 men and 80 women, 159 adults and 31 children with the age between 1 and 64 years old (mean age--39.9). The main indication in the adult group was represented by viral cirrhosis, while the pediatric series the etiology was mainly glycogenosis and biliary atresia. There were performed 143 whole graft LTs, 46 living donor LTs, 6 split LTs, 4 reduced LTs and one domino LT RESULTS: The postoperative survival was 90% (170 patients). The patient and graft one-year and five-year survivals were 76.9%, 73.6% and 71%, 68.2%, respectively. The early complications occurred in 127 patients (67%). The late complications were recorded in 71 patients (37.3%). The intraoperative and early postoperative mortality rate was 9.5% (18 patients). The Romanian liver transplantation program from Fundeni includes all types of current surgical techniques and the results are comparable with those from other international centers.

  9. 25 Ways to Love Your Liver

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  10. Finite Element Analysis and Test Results Comparison for the Hybrid Wing Body Center Section Test Article

    Science.gov (United States)

    Przekop, Adam; Jegley, Dawn C.; Rouse, Marshall; Lovejoy, Andrew E.

    2016-01-01

    This report documents the comparison of test measurements and predictive finite element analysis results for a hybrid wing body center section test article. The testing and analysis efforts were part of the Airframe Technology subproject within the NASA Environmentally Responsible Aviation project. Test results include full field displacement measurements obtained from digital image correlation systems and discrete strain measurements obtained using both unidirectional and rosette resistive gauges. Most significant results are presented for the critical five load cases exercised during the test. Final test to failure after inflicting severe damage to the test article is also documented. Overall, good comparison between predicted and actual behavior of the test article is found.

  11. Relationship between substances in seminal plasma and Acrobeads Test results.

    Science.gov (United States)

    Komori, Kazuhiko; Tsujimura, Akira; Okamoto, Yoshio; Matsuoka, Yasuhiro; Takao, Tetsuya; Miyagawa, Yasushi; Takada, Shingo; Nonomura, Norio; Okuyama, Akihiko

    2009-01-01

    To asses the effects of seminal plasma on sperm function. Retrospective case-control study. University hospital. One hundred fourteen infertile men. Acrobeads Test scores (0-4) and measurement of interleukin (IL)-6, soluble IL-6 receptor, epidermal growth factor, insulin-like growth factor-I (IGF-I), transforming growth factor-beta I, superoxide dismutase, calcitonin, and macrophage migration inhibitory factor (MIF) levels in seminal plasma. Kruskal-Wallis test to compare the concentrations of substances as a nonparametric test for differences among Acrobeads Test scores and a multivariable logistic regression model to find independent risk factors associated with abnormal Acrobeads Test results. The Acrobeads Test score was 0 for 7 samples, 1 for 20 samples, 2 for 18 samples, 3 for 28 samples, and 4 for 41 samples. Age, abstinence period, and semen parameters, except for sperm motility and percentage of sperm with abnormal morphology, had no effect on the Acrobeads Test results. Concentrations of IGF-I and MIF were significantly higher in patients with abnormal Acrobeads Test results. Multivariate analysis indicated that MIF and IGF-I were significantly associated with abnormal Acrobeads Test results (scores 0 to 1). Although further studies are needed, IGF-I and MIF in seminal plasma may have negative effects on sperm function.

  12. Results of recent KROTOS FCI tests. Alumina vs. corium melts

    Energy Technology Data Exchange (ETDEWEB)

    Huhtiniemi, I.; Magallon, D.; Hohmann, H. [Commission of the European Communities, Ispra (Italy). Joint Research Center

    1998-01-01

    Recent results from KROTOS fuel-coolant interaction experiments are discussed. Five tests with alumina were performed under highly subcooled conditions, all of these tests resulted in spontaneous steam explosions. Additionally, four tests were performed at low subcooling to confirm, on one hand, the suppression of spontaneous steam explosions under such conditions and, on the other hand, that such a system is still triggerable using an external initiator. The other test parameters in these alumina tests included the melt superheat and the initial pressure. All the tests in the investigated superheat range (150 K - 750 K) produced a steam explosion and no evidence of the explosion suppression by the elevated initial pressure (in the limited range of 0.1 - 0.375 MPa) was observed in the alumina tests. The corium test series include a test with 3 kg of melt under both subcooled and near saturated conditions at ambient pressure. Two additional tests were performed with subcooled water; one test was performed at an elevated pressure of 0.2 MPa with 2.4 kg of melt and another test with 5.1 kg of melt at ambient pressure. None of these tests with corium produced a propagating energetic steam explosion. However, propagating low energy (about twice the energy of the trigger pulse) events were observed. All corium tests produced significantly higher water level swells during the mixing phase than the corresponding alumina tests. Present experimental evidence suggests that the water depletion in the mixing zone suppresses energetic steam explosions with corium melts at ambient pressure and in the present pour geometry. Processes that could produce such a difference in void generation are discussed. (author)

  13. Physical and chemical test results of electrostatic safe flooring materials

    Science.gov (United States)

    Gompf, R. H.

    1988-01-01

    This test program was initiated because a need existed at the Kennedy Space Center (KSC) to have this information readily available to the engineer who must make the choice of which electrostatic safe floor to use in a specific application. The information, however, should be of value throughout both the government and private industry in the selection of a floor covering material. Included are the test results of 18 floor covering materials which by test evaluation at KSC are considered electrostatically safe. Tests were done and/or the data compiled in the following areas: electrostatics, flammability, hypergolic compatibility, outgassing, floor type, material thickness, and available colors. Each section contains the test method used to gather the data and the test results.

  14. Thermal results of the Japanese LCT coil's domestic test

    International Nuclear Information System (INIS)

    Tada, Eisuke; Hiyama, Tadao; Kato, Takashi; Takahashi, Osamu; Shimamoto, Susumu

    1984-01-01

    This paper describes thermal results obtained in the domestic test of the Japanese LCT coil which was constructed at the Japan Atomic Energy Research Institute (JAERI) in order to develop large superconducting coils for fusion in international collaboration proposed by the IEA. The domestic test was carried out from May 13 to June 17 in 1982 by using the test facility named as SETF (Superconducting Engineering Test Facility) which was composed of a 350-l/h helium cryogenic system, a vacuum system, a 30 KA-DC power supply and protection system, and a PDP-11/70 computer system. The cool-down characteristics, heat load, fast discharge characteristics, stability, and warm-up characteristics of the LCT coil were successfully measured in the test. The details of thermal test results acquired in the cool-down, heat load measurement, fast discharge, and warm-up, and the comparison between measurements and calculations are described in this paper. (author)

  15. Potential use of metabolic breath tests to assess liver disease and prognosis: has the time arrived for routine use in the clinic?

    Science.gov (United States)

    Stravitz, R Todd; Ilan, Yaron

    2017-03-01

    The progression of liver disease may be unique among organ system diseases in that progressive fibrosis compromises not only the sufficiency of hepatocyte mass but also impairs blood flow to the liver, resulting in porto-systemic shunting. Although liver biopsy as an assessment of fibrosis has become the key biomarker of and target for new therapies, it is invasive and subject to sampling error, and cannot quantify metabolic function or porto-systemic shunting. Measurement of the hepatic venous pressure gradient accommodates some of the deficiencies of biopsy but requires expertise not widely available and misses minor changes in hepatocellular mass and thereby information about metabolic function. Thus, an unmet need in clinical hepatology remains unfulfilled: a noninvasive biomarker which quantitates both the hepatocellular insufficiency and porto-systemic shunting inherent in progressive hepatic fibrosis. Ideally, such a biomarker should correlate with clinical endpoints including liver-related survival and cirrhotic complications, be performed at the point-of-care, and be affordable and easy to use. This review, an expert opinion, summarizes background and recent data suggesting that metabolic breath tests may now meet these requirements and have a valid place in clinical hepatology to supplant the time-honoured assessment of hepatic fibrosis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Commissioning and First Results from the Fermilab Cryomodule Test Stand

    Energy Technology Data Exchange (ETDEWEB)

    Harms, Elvin; et al.

    2017-05-01

    A new test stand dedicated to SRF cryomodule testing, CMTS1, has been commissioned and is now in operation at Fermilab. The first device to be cooled down and powered in this facility is the prototype 1.3 GHz cryomodule assembled at Fermilab for LCLS-II. We describe the demonstrated capabilities of CMTS1, report on steps taken during commissioning, provide an overview of first test results, and survey future plans.

  17. Sims Prototype System 2 test results: Engineering analysis

    Science.gov (United States)

    1978-01-01

    The testing, problems encountered, and the results and conclusions obtained from tests performed on the IBM Prototype System, 2, solar hot water system, at the Marshall Space Flight Center Solar Test Facility was described. System 2 is a liquid, non draining solar energy system for supplying domestic hot water to single residences. The system consists of collectors, storage tank, heat exchanger, pumps and associated plumbing and controls.

  18. MR elastography of the liver at 3 T with cine-tagging and bending energy analysis: preliminary results

    International Nuclear Information System (INIS)

    Watanabe, Haruo; Kanematsu, Masayuki; Kondo, Hiroshi; Goshima, Satoshi; Kajita, Kimihiro; Kitagawa, Teruhiko; Suzuki, Yuriko; Bae, Kyongtae T.; Hirose, Yoshinobu; Miotani, Seiki; Zhou, Xiangrong; Fujita, Hiroshi

    2010-01-01

    To preliminarily evaluate the feasibility and usefulness of MR elastography of the liver at 3 T with cine-tagging and bending energy (BE) analysis for the evaluation of hepatic fibrosis. Twenty-two patients underwent MR elastography with four different cine-tagging grids on the liver (16- or 20-mm sagittal or coronal). Nine images serially obtained during 1-s of exhalation were analyzed to define coordinates of grid intersections. BE values were calculated using the thin-plate spline method. BE values were compared among patient groups with different fibrosis stage thresholds. In the 22 patients, six had a fibrosis score of F0, one had F1, seven had F2, three had F3, and five had F4. Mean BE value with 16-mm sagittal grid was greater with fibrosis score F0 (1.54 ± 0.63) than with ≥F1 (0.97 ± 0.12, P = 0.013) as well as with ≤F1 (1.48 ± 0.60) than with ≥F2 (0.96 ± 0.36, P = 0.019). Our results showed that MR elastography with 16-mm sagittal grid and BE analysis had a potential in discrimination for the patients with moderate or advanced hepatic fibrosis from those with healthy liver or slight fibrosis. (orig.)

  19. Is Antibiotic Prophylaxis for Percutaneous Radiofrequency Ablation (RFA) of Primary Liver Tumors Necessary? Results From a Single-Center Experience

    International Nuclear Information System (INIS)

    Bhatia, Shivank S.; Spector, Seth; Echenique, Ana; Froud, Tatiana; Suthar, Rekha; Lawson, Ivy; Dalal, Ravi; Dinh, Vy; Yrizarry, Jose; Narayanan, Govindarajan

    2015-01-01

    PurposeThe purpose of this study was to evaluate need for antibiotic prophylaxis for radiofrequency ablation (RFA) of liver tumors in patients with no significant co-existing risk factors for infection.Materials and MethodsFrom January 2004 to September 2013, 83 patients underwent 123 percutaneous RFA procedures for total of 152 hepatocellular carcinoma (HCC) lesions. None of the patients had pre-existing biliary enteric anastomosis (BEA) or any biliary tract abnormality predisposing to ascending biliary infection or uncontrolled diabetes mellitus. No pre- or post-procedure antibiotic prophylaxis was provided for 121 procedures. Data for potential risk factors were reviewed retrospectively and analyzed for the frequency of infectious complications, including abscess formation.ResultsOne patient (1/121 (0.8 %) RFA sessions) developed a large segment 5 liver abscess/infected biloma communicating with the gallbladder 7 weeks after the procedure, successfully treated over 10 weeks with IV and PO antibiotic therapy and percutaneous catheter drainage. This patient did not receive any antibiotics prior to RFA. During the procedure, there was inadvertent placement of RFA probe tines into the gallbladder. No other infectious complications were documented.ConclusionThese data suggest that the routine use of prophylactic antibiotics for liver RFA is not necessary in majority of the patients undergoing liver ablation for HCC and could be limited to patients with high-risk factors such as the presence of BEA or other biliary abnormalities, uncontrolled diabetes mellitus, and large centrally located tumors in close proximity to central bile ducts. Larger randomized studies are needed to confirm this hypothesis

  20. Effect of Testosterone Administration on Liver Fat in Older Men With Mobility Limitation: Results From a Randomized Controlled Trial

    Science.gov (United States)

    2013-01-01

    Background. Androgen receptor (AR) knockout male mice display hepatic steatosis, suggesting that AR signaling may regulate hepatic fat. However, the effects of testosterone replacement on hepatic fat in men are unknown. The aim of this study was to determine the effects of testosterone administration on hepatic fat in older men with mobility limitation and low testosterone levels who were participating in a randomized trial (the Testosterone in Older Men trial). Methods. Two hundred and nine men with mobility limitation and low total or free testosterone were randomized in the parent trial to either placebo or 10-g testosterone gel daily for 6 months. Hepatic fat was determined by magnetic resonance imaging in 73 men (36 in placebo and 37 in testosterone group) using the volumetric method. Insulin sensitivity (homeostatic model assessment–insulin resistance) was derived from fasting glucose and insulin. Results. Baseline characteristics were similar between the two groups, including liver volumes (1583±363 in the testosterone group vs 1522±271mL in the placebo group, p = .42). Testosterone concentrations increased from 250±72 to 632±363ng/dL in testosterone group but did not change in placebo group. Changes in liver volume during intervention did not differ significantly between groups (p = .5) and were not related to on-treatment testosterone concentrations. The change in homeostatic model assessment–insulin resistance also did not differ significantly between groups and was not related to either baseline or change in liver fat. Conclusion. Testosterone administration in older men with mobility limitation and low testosterone levels was not associated with a reduction in hepatic fat. Larger trials are needed to determine whether testosterone replacement improves liver fat in men with nonalcoholic hepatic steatosis. PMID:23292288

  1. Is Antibiotic Prophylaxis for Percutaneous Radiofrequency Ablation (RFA) of Primary Liver Tumors Necessary? Results From a Single-Center Experience

    Energy Technology Data Exchange (ETDEWEB)

    Bhatia, Shivank S., E-mail: sbhatia1@med.miami.edu [University of Miami, Vascular/Interventional Radiology, Department of Radiology, Miller School of Medicine (United States); Spector, Seth, E-mail: sspector@med.miami.edu [University of Miami, Department of Surgery, VA Hospital (Veterans Affairs Medical Center) (United States); Echenique, Ana, E-mail: aechenique@med.miami.edu; Froud, Tatiana, E-mail: tfroud@med.miami.edu; Suthar, Rekha, E-mail: rsuthar@med.miami.edu; Lawson, Ivy, E-mail: i.lawson1@med.miami.edu; Dalal, Ravi, E-mail: rdalal@med.miami.edu [University of Miami, Vascular/Interventional Radiology, Department of Radiology, Miller School of Medicine (United States); Dinh, Vy, E-mail: vdinh@med.miami.edu [VA Hospital (Veterans Affairs Medical Center), Department of Medicine (United States); Yrizarry, Jose, E-mail: jyrizarr@med.miami.edu; Narayanan, Govindarajan, E-mail: gnarayanan@med.miami.edu [University of Miami, Vascular/Interventional Radiology, Department of Radiology, Miller School of Medicine (United States)

    2015-08-15

    PurposeThe purpose of this study was to evaluate need for antibiotic prophylaxis for radiofrequency ablation (RFA) of liver tumors in patients with no significant co-existing risk factors for infection.Materials and MethodsFrom January 2004 to September 2013, 83 patients underwent 123 percutaneous RFA procedures for total of 152 hepatocellular carcinoma (HCC) lesions. None of the patients had pre-existing biliary enteric anastomosis (BEA) or any biliary tract abnormality predisposing to ascending biliary infection or uncontrolled diabetes mellitus. No pre- or post-procedure antibiotic prophylaxis was provided for 121 procedures. Data for potential risk factors were reviewed retrospectively and analyzed for the frequency of infectious complications, including abscess formation.ResultsOne patient (1/121 (0.8 %) RFA sessions) developed a large segment 5 liver abscess/infected biloma communicating with the gallbladder 7 weeks after the procedure, successfully treated over 10 weeks with IV and PO antibiotic therapy and percutaneous catheter drainage. This patient did not receive any antibiotics prior to RFA. During the procedure, there was inadvertent placement of RFA probe tines into the gallbladder. No other infectious complications were documented.ConclusionThese data suggest that the routine use of prophylactic antibiotics for liver RFA is not necessary in majority of the patients undergoing liver ablation for HCC and could be limited to patients with high-risk factors such as the presence of BEA or other biliary abnormalities, uncontrolled diabetes mellitus, and large centrally located tumors in close proximity to central bile ducts. Larger randomized studies are needed to confirm this hypothesis.

  2. Liver transplant

    Science.gov (United States)

    Hepatic transplant; Transplant - liver; Orthotopic liver transplant; Liver failure - liver transplant; Cirrhosis - liver transplant ... The donated liver may be from: A donor who has recently died and has not had liver injury. This type of ...

  3. Clinical investigation of fatty liver by CT

    International Nuclear Information System (INIS)

    Kato, Katsumoto; Takayama, Tetsuo; Sano, Hiroshi; Katada, Naoyuki; Takeichi, Masayuki

    1984-01-01

    CT findings of 56 cases of diffuse fatty infiltration comfirmed by liver biopsy were investigated and compared with those of chronic hepatitis and liver cirrhosis. We found that the diagnosis of severe fatty infiltration (fatty liver) can be specifically possible when the ratios of CT values of liver to those of spleen are less than 0.85 and it is reasonable criterion for diagnosis of fatty liver by CT. This criterion was satisfied by 197 studies (2.9%), 169 cases with fatty liver (diffuse: 141 cases, focal: 28 cases) of 6800 CT studies of liver. Obesity, diabetes and alcohol abuse were main causative factors in both diffuse and focal fatty liver. The percentage of cases showing no abnormal results in blood chemistry tests was great compared with the previous report based on liver biopsy. The changes of CT values of liver faithfully reflected the improvement of each causal factor and reciprocal changes were observed between diffuse and focal fatty liver in repeated CT examination. So, CT is useful in estimating the effect of treatment as well as in diagnosis of fatty liver. Focal fatty liver is temporary manifestation during the proscess of development or improvement of fatty liver. (author)

  4. Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells

    Directory of Open Access Journals (Sweden)

    Xiang Y. Kong

    2014-03-01

    Full Text Available Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. To gain insight into the physiological function of NCU-G1, mice with no detectable expression of this gene were created using a gene-trap strategy, and Ncu-g1gt/gt mice were successfully characterized. Lysosomal disorders are mainly caused by lack of or malfunctioning of proteins in the endosomal-lysosomal pathway. The clinical symptoms vary, but often include liver dysfunction. Persistent liver damage activates fibrogenesis and, if unremedied, eventually leads to liver fibrosis/cirrhosis and death. We demonstrate that the disruption of Ncu-g1 results in spontaneous liver fibrosis in mice as the predominant phenotype. Evidence for an increased rate of hepatic cell death, oxidative stress and active fibrogenesis were detected in Ncu-g1gt/gt liver. In addition to collagen deposition, microscopic examination of liver sections revealed accumulation of autofluorescent lipofuscin and iron in Ncu-g1gt/gt Kupffer cells. Because only a few transgenic mouse models have been identified with chronic liver injury and spontaneous liver fibrosis development, we propose that the Ncu-g1gt/gt mouse could be a valuable new tool in the development of novel treatments for the attenuation of fibrosis due to chronic liver damage.

  5. The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

    Science.gov (United States)

    Suzery, M.; Cahyono, B.; Astuti, P.

    2017-02-01

    Plants from Lamiaceae family has almost entirely reported having physiological activities. One of them is Hyptis pectinata Poit plant. Research on the toxicity of Hyptis pectinata needs to be done to protect people from the possibility of its harmful effects. This study aim to know the acute toxicity effects of Hyptis pectinata extract (HPE) on liver of Balb/c mice. This research was a laboratory experimental study using the post test only controlled group design. Balb/c mice were randomly divided into 4 groups. K (control group), P1, P2 and P3 (treatment groups; given HPE 200mg/kgBW, 1000 mg/kgBW, and 5000 mg/kgBW, respectively). The extract was orally given with gastric tube on the first day and the mice were terminated at the 8th day then the livers were observed. The Kruskal-Wallis test for macroscopic morphological and volume of the liver showed there were no significant difference with p=0.406 and p=0.054. The highest liver histopathological score was in P3 group. The Kruskal-Wallis test showed significantly difference (p=0.000). Continued with Mann-Withney test that showed a significant difference in K-P1 (p=0.009), K-P2 (p=0.009), K-P3 (p=0.009), P1-P2 (p=0.028), and P1-P3 (p=0.009). In conclusion, the HPE is safe to use which has no complication with liver of mice.

  6. RTG performance on Galileo and Ulysses and Cassini test results

    International Nuclear Information System (INIS)

    Kelly, C. Edward; Klee, Paul M.

    1997-01-01

    Power output from telemetry for the two Galileo RTGs are shown from the 1989 launch to the recent Jupiter encounter. Comparisons of predicted, measured and required performance are shown. Similar comparisons are made for the RTG on the Ulysses spacecraft which completed its planned mission in 1995. Also presented are test results from small scale thermoelectric modules and full scale converters performed for the Cassini program. The Cassini mission to Saturn is scheduled for an October 1997 launch. Small scale module test results on thermoelectric couples from the qualification and flight production runs are shown. These tests have exceeded 19,000 hours are continuing to provide increased confidence in the predicted long term performance of the Cassini RTGs. Test results are presented for full scale units both ETGs (E-6, E-7) and RTGs (F-2, F-5) along with mission power predictions. F-5, fueled in 1985, served as a spare for the Galileo and Ulysses missions and plays the same role in the Cassini program. It has successfully completed all acceptance testing. The ten years storage between thermal vacuum tests is the longest ever experienced by an RTG. The data from this test are unique in providing the effects of long term low temperature storage on power output. All ETG and RTG test results to date indicate that the power requirements of the Cassini spacecraft will be met. BOM and EOM power margins of at least five percent are predicted

  7. RTG performance on Galileo and Ulysses and Cassini test results

    International Nuclear Information System (INIS)

    Kelly, C.E.; Klee, P.M.

    1997-01-01

    Power output from telemetry for the two Galileo RTGs are shown from the 1989 launch to the recent Jupiter encounter. Comparisons of predicted, measured and required performance are shown. Similar comparisons are made for the RTG on the Ulysses spacecraft which completed its planned mission in 1995. Also presented are test results from small scale thermoelectric modules and full scale converters performed for the Cassini program. The Cassini mission to Saturn is scheduled for an October 1997 launch. Small scale module test results on thermoelectric couples from the qualification and flight production runs are shown. These tests have exceeded 19,000 hours are continuing to provide increased confidence in the predicted long term performance of the Cassini RTGs. Test results are presented for full scale units both ETGs (E-6, E-7) and RTGs (F-2, F-5) along with mission power predictions. F-5, fueled in 1985, served as a spare for the Galileo and Ulysses missions and plays the same role in the Cassini program. It has successfully completed all acceptance testing. The ten years storage between thermal vacuum tests is the longest ever experienced by an RTG. The data from this test are unique in providing the effects of long term low temperature storage on power output. All ETG and RTG test results to date indicate that the power requirements of the Cassini spacecraft will be met. BOM and EOM power margins of at least five percent are predicted. copyright 1997 American Institute of Physics

  8. Results of EMC market surveillance tests for UPS systems

    Energy Technology Data Exchange (ETDEWEB)

    Rajamaeki, J. [Safety Technology Authority, Helsinki (Finland)

    1997-12-31

    This paper reports the first wide electromagnetic compatibility (EMC) market surveillance project in Finland in which the uninterruptible power systems (UPS) on the Finnish market are monitored. Altogether 11 UPS units are EMC tested and the results of these tests are described in this paper. The effect of basic characters of UPS on the level of electromagnetic interference are analysed. (orig.) 3 refs.

  9. 7 CFR 91.24 - Reports of test results.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Reports of test results. 91.24 Section 91.24 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS...

  10. Power-cooling mismatch test series. Test PCM-2A; test results report

    International Nuclear Information System (INIS)

    Cawood, G.W.; Holman, G.W.; Martinson, Z.R.; Legrand, B.L.

    1976-09-01

    The report describes the results of an in-pile experimental investigation of pre- and postcritical heat flux (CHF) behavior of a single 36-inch-long, pressurized water reactor (PWR) type, UO 2 -fueled, zircaloy-clad fuel rod. The nominal coolant conditions for pressure and temperature were representative of those found in a commercial PWR. Nine separate departures from nucleate boiling (DNB) cycles were performed by either of two different methods: (a) decreasing the coolant flow rate while the fuel rod power was held constant, or (b) increasing the fuel rod power while the coolant flow rate was held constant. DNB was obtained during eight of the nine cycles performed. For the final flow reduction, the mass flux was decreased to 6.1 x 10 5 lb/hr-ft 2 at a constant peak linear heat generation rate of 17.8 kW/ft. The fuel rod was allowed to remain in film boiling for about 210 seconds during this final flow reduction. The fuel rod remained intact during the test. Results of on-line measurements of the fuel rod behavior are presented together with discussion of instrument performance. A comparison of the data with Fuel Rod Analysis Program-Transient 2 (FRAP-T2) computer code calculations is included

  11. Drug and alcohol testing results 2009 annual report

    Science.gov (United States)

    2013-11-01

    This is the 15th annual report of the results of the Federal Transit Administrations (FTA) Drug and Alcohol Testing Program. This report summarizes the reporting requirements for calendar year 2009, the requirements of the overall drug and alcohol...

  12. Drug and alcohol testing results 2007 annual report

    Science.gov (United States)

    2009-05-01

    This is the 13th annual report of the results of the Federal Transit Administrations (FTA) Drug and Alcohol Testing Program. This report summarizes the reporting requirements for calendar year 2007, the requirements of the overall drug and alcohol...

  13. Drug and Alcohol Testing Results 2008 Annual Report

    Science.gov (United States)

    2010-09-01

    This is the 14th annual report of the results of the Federal Transit Administration's (FTA) Drug and Alcohol Testing : Program. This report summarizes the reporting requirements for calendar year 2008, the requirements of the overall : drug and alcoh...

  14. Drug and alcohol testing results 2006 annual report.

    Science.gov (United States)

    2008-08-01

    This is the 12th annual report of the results of the Federal Transit Administration's (FTA) Drug and Alcohol Testing Program. This report summarizes the reporting requirements for calendar year 2006, the requirements of the overall drug and alcohol t...

  15. Results from tests of the Delphi TPC prototype

    International Nuclear Information System (INIS)

    Vilanova, D.

    1985-01-01

    Results from beam tests of a half-scale sector of the Delphi TPC are presented. The spatial resolution is slightly higher than predicted by Monte Carlo simulations, corresponding to an average value of about 300 μm. (orig.)

  16. Test emission of uranium hexafluoride in atmosphere. Results interpretation

    International Nuclear Information System (INIS)

    Crabol, B.; Deville-Cavelin, G.

    1989-01-01

    To permit the modelization of gaseous uranium hexafluoride behaviour in atmosphere, a validation test has been executed the 10 April 1987. The experimental conditions, the main results and a comparison with a diffusion model are given in this report [fr

  17. Interim results from UO2 fuel oxidation tests in air

    International Nuclear Information System (INIS)

    Campbell, T.K.; Gilbert, E.R.; Thornhill, C.K.; White, G.D.; Piepel, G.F.; Griffin, C.W.j.

    1987-08-01

    An experimental program is being conducted at Pacific Northwest Laboratory (PNL) to extend the characterization of spent fuel oxidation in air. To characterize oxidation behavior of irradiated UO 2 , fuel oxidation tests were performed on declad light-water reactor spent fuel and nonirradited UO 2 pellets in the temperature range of 135 to 250 0 C. These tests were designed to determine the important independent variables that might affect spent fuel oxidation behavior. The data from this program, when combined with the test results from other programs, will be used to develop recommended spent fuel dry-storage temperature limits in air. This report describes interim test results. The initial PNL investigations of nonirradiated and spent fuels identified the important testing variables as temperature, fuel burnup, radiolysis of the air, fuel microstructure, and moisture in the air. Based on these initial results, a more extensive statistically designed test matrix was developed to study the effects of temperature, burnup, and moisture on the oxidation behavior of spent fuel. Oxidation tests were initiated using both boiling-water reactor and pressurized-water reactor fuels from several different reactors with burnups from 8 to 34 GWd/MTU. A 10 5 R/h gamma field was applied to the test ovens to simulate dry storage cask conditions. Nonirradiated fuel was included as a control. This report describes experimental results from the initial tests on both the spent and nonirradiated fuels and results to date on the tests in a 10 5 R/h gamma field. 33 refs., 51 figs., 6 tabs

  18. NNWSI Phase II materials interaction test procedure and preliminary results

    International Nuclear Information System (INIS)

    Bates, J.K.; Gerding, T.J.

    1985-01-01

    The Nevada Nuclear Waste Storage Investigations (NNWSI) project is investigating the volcanic tuff beds of Yucca Mountain, Nevada, as a potential location for a high-level radioactive waste repository. This report describes a test method (Phase II) that has been developed to measure the release of radionuclides from the waste package under simulated repository conditions, and provides information on materials interactions that may occur in the repository. The results of 13 weeks of testing using the method are presented, and an analog test is described that investigates the relationship between the test method and expected repository conditions. 9 references, 10 figures, 11 tables

  19. Recent test results on the ATLAS SCT detector

    International Nuclear Information System (INIS)

    Pernegger, H.

    2003-01-01

    The ATLAS Semiconductor Tracker (SCT) will be a central part of the tracking system of the ATLAS experiment. The SCT, which is currently under construction, will consist of four concentric barrels of silicon detectors as well as two silicon endcap detectors formed by nine disks each. After an overview of the SCT and the detector module layout, the paper will summarize recent test results obtained from silicon detector modules, which have been extensively tested before starting their large series production. The tests presented here cover electrical performance of individual modules, their performance after irradiation, as well as system tests in a multi-module setup

  20. Preliminary results of steel containment vessel model test

    International Nuclear Information System (INIS)

    Matsumoto, T.; Komine, K.; Arai, S.

    1997-01-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11-12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented

  1. Test results on reuse of reclaimed shower water - A summary

    Science.gov (United States)

    Verostko, Charles E.; Garcia, Rafael; Sauer, Richard; Reysa, Richard P.; Linton, Arthur T.

    1989-01-01

    Results are presented from tests to evaluate a microgravity whole body shower and waste water recovery system design for possible use on the Space Station. Several water recovery methods were tested, including phase change distillation, a thermoelectric hollow fiber membrane evaporation subsystem, and a reverse osmosis dynamic membrane system. Consideration is given to the test hardware, the types of soaps evaluated, the human response to showering with reclaimed water, chemical treatment for microbial control, the procedures for providing hygienic water, and the quality of water produced by the systems. All three of the waste water recovery systems tested successfully produced reclaimed water for reuse.

  2. Quantitative magnetic resonance methods for in vivo investigation of the human liver and spleen. Technical aspects and preliminary clinical results

    DEFF Research Database (Denmark)

    Thomsen, C

    1996-01-01

    and a group of patients with benign hyperplasia and patients with splenomegaly secondary to portal hypertension. Volume-selective proton spectroscopy was developed and used to quantify the liver fat concentration. The accuracy of the method was about 3 g/100 g. With the implementation of a second generation...... contribute to the diagnosis of non-focal liver diseases by estimation of liver fat and liver iron and by assessment of portal vein blood flow. Increased T1 relaxation time is a sign of a disease process in the liver rather than specific for any liver disease...

  3. Acoustic radiation force impulse elastography of the liver. Can fat deposition in the liver affect the measurement of liver stiffness?

    International Nuclear Information System (INIS)

    Motosugi, Utaroh; Ichikawa, Tomoaki; Araki, Tsutomu; Niitsuma, Yoshibumi

    2011-01-01

    The aim of this study was to compare acoustic radiation force impulse (ARFI) results between livers with and without fat deposition. We studied 200 consecutive healthy individuals who underwent health checkups at our institution. The subjects were divided into three groups according to the echogenicity of the liver on ultrasonography (US) and the liver-spleen attenuation ratio index (LSR) on computed tomography: normal liver group (n=121, no evidence of bright liver on US and LSR >1); fatty liver group (n=46, bright liver on US and LSR 5 days a week (n=18) were excluded from the analysis. The velocities measured by ARFI in the normal and fatty liver groups were compared using the two one-sided test. The mean (SD) velocity measured in the normal and fatty liver groups were 1.03 (0.12) m/s and 1.02 (0.12) m/s, respectively. The ARFI results of the fatty liver group were similar to those of the normal liver group (P<0.0001). This study suggested that fat deposition in the liver does not affect the liver stiffness measurement determined by ARFI. (author)

  4. Assessment of the variations in fat content in normal liver using a fast MR imaging method in comparison with results obtained by spectroscopic imaging

    International Nuclear Information System (INIS)

    Irwan, Roy; Edens, Mireille A.; Sijens, Paul E.

    2008-01-01

    A recently published Dixon-based MRI method for quantifying liver fat content using dual-echo breath-hold gradient echo imaging was validated by phantom experiments and compared with results of biopsy in two patients (Radiology 2005;237:1048-1055). We applied this method in ten healthy volunteers and compared the outcomes with the results of MR spectroscopy (MRS), the gold standard in quantifying liver fat content. Novel was the use of spectroscopic imaging yielding the variations in fat content across the liver rather than a single value obtained by single voxel MRS. Compared with the results of MRS, liver fat content according to MRI was too high in nine subjects (range 3.3-10.7% vs. 0.9-7.7%) and correct in one (21.1 vs. 21.3%). Furthermore, in one of the ten subjects the MRI fat content according to the Dixon-based MRI method was incorrect due to a (100-x) versus x percent lipid content mix-up. The second problem was fixed by a minor adjustment of the MRI algorithm. Despite systematic overestimation of liver fat contents by MRI, Spearman's correlation between the adjusted MRI liver fat contents with MRS was high (r = 0.927, P < 0.001). Even after correction of the algorithm, the problem remaining with the Dixon-based MRI method for the assessment of liver fat content,is that, at the lower end range, liver fat content is systematically overestimated by 4%. (orig.)

  5. Shared liver-like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors.

    Science.gov (United States)

    Cheng, Jun; Song, Xuekun; Ao, Lu; Chen, Rou; Chi, Meirong; Guo, You; Zhang, Jiahui; Li, Hongdong; Zhao, Wenyuan; Guo, Zheng; Wang, Xianlong

    2018-01-01

    Background & Aims : Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma. Methods: Among the genes up-regulated in normal liver tissues versus normal colorectal tissues, we identified "liver-specific" genes whose expression levels ranked among the bottom 10% ("unexpressed") of all measured genes in both normal colorectal tissues and primary colorectal tumors without metastasis. These liver-specific genes were investigated for their expressions in both the primary tumors and the corresponding liver metastases of seven primary CRC patients with liver metastasis using microdissected samples. Results: Among the 3958 genes detected to be up-regulated in normal liver tissues versus normal colorectal tissues, we identified 12 liver-specific genes and found two of them, ANGPTL3 and CFHR5 , were unexpressed in microdissected primary colorectal tumors without metastasis but expressed in both microdissected liver metastases and corresponding primary colorectal tumors (Fisher's exact test, P colorectal tumors may express some liver-specific genes which may help the tumor cells adapt the liver micro-environment.

  6. Structural fatigue test results for large wind turbine blade sections

    Science.gov (United States)

    Faddoul, J. R.; Sullivan, T. L.

    1982-01-01

    In order to provide quantitative information on the operating life capabilities of wind turbine rotor blade concepts for root-end load transfer, a series of cantilever beam fatigue tests was conducted. Fatigue tests were conducted on a laminated wood blade with bonded steel studs, a low cost steel spar (utility pole) with a welded flange, a utility pole with additional root-end thickness provided by a swaged collar, fiberglass spars with both bonded and nonbonded fittings, and, finally, an aluminum blade with a bolted steel fitting (Lockheed Mod-0 blade). Photographs, data, and conclusions for each of these tests are presented. In addition, the aluminum blade test results are compared to field failure information; these results provide evidence that the cantilever beam type of fatigue test is a satisfactory method for obtaining qualitative data on blade life expectancy and for identifying structurally underdesigned areas (hot spots).

  7. Influence of diet on the results of laboratory tests

    Directory of Open Access Journals (Sweden)

    Kinga Lis

    2013-12-01

    Full Text Available Blood and urine laboratory tests are necessary to diagnose the state of the patient. These tests are also helpful in the assessment of diet and nutritional status of the organism. It is recommended that both blood and urine for laboratory tests be collected in the morning, from fasting patients after an overnight rest. These conditions are defined as the standard conditions for collection of material for laboratory testing. Before testing, patients should follow their natural diet and avoid physical exertion, night work, long-distance travel, as well as consumption of alcohol and drugs. They should also reduce the consumption of synthetic vitamins and herbal remedies and other dietary supplements. Medications should be limited to those that are absolutely necessary. All of these factors can affect the results of laboratory tests.

  8. Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.

    Science.gov (United States)

    Bosselut, Nelly; Taibi, Ludmia; Guéchot, Jérôme; Zarski, Jean-Pierre; Sturm, Nathalie; Gelineau, Marie-Christine; Poggi, Bernard; Thoret, Sophie; Lasnier, Elisabeth; Baudin, Bruno; Housset, Chantal; Vaubourdolle, Michel

    2013-01-16

    Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have been recently developed, i.e. transient elastography (Fibroscan™) and blood tests (Fibrometer®, Fibrotest®, and Hepascore®). In this study, we aimed to design a new score in chronic hepatitis C (CHC) by selecting blood markers in a large panel and we compared its diagnostic performance with those of other noninvasive methods. Sixteen blood tests were performed in 306 untreated CHC patients included in a multicenter prospective study (ANRS HC EP 23 Fibrostar) using METAVIR histological fibrosis stage as reference. The new score was constructed by non linear regression using the most accurate biomarkers. Five markers (alpha-2-macroglobulin, apolipoprotein-A1, AST, collagen IV and osteoprotegerin) were included in the new function called Coopscore©. Using the Obuchowski Index, Coopscore© shows higher diagnostic performances than for Fibrometer®, Fibrotest®, Hepascore® and Fibroscan™ in CHC. Association between Fibroscan™ and Coopscore© might avoid 68% of liver biopsies for the diagnosis of significant fibrosis. Coopscore© provides higher accuracy than other noninvasive methods for the diagnosis of liver fibrosis in CHC. The association of Coopscore© with Fibroscan™ increases its predictive value. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. Results of tests with open fuel in KNK II

    International Nuclear Information System (INIS)

    Schmitz, G.

    1987-03-01

    For the operation of Liquid Metal Cooled Fast Breeder Reactors with cladding failures the consequences of increased contamination by fission products and fuel and the possibility of failure propagation to adjacent fuel pins due to fuel swelling have to be envisaged. To clarify some of these problems a KNK II test program involving open fuel was defined with the first experiments of this program being performed between October 1981 and May 1984. After the description of the test equipment and of the test program, the results will be presented on delayed neutron measurements, fission gas measurements and post irradiation examinations. The report will conclude with a discussion of the results [de

  10. A Fuzzy Logic Based Method for Analysing Test Results

    Directory of Open Access Journals (Sweden)

    Le Xuan Vinh

    2017-11-01

    Full Text Available Network operators must perform many tasks to ensure smooth operation of the network, such as planning, monitoring, etc. Among those tasks, regular testing of network performance, network errors and troubleshooting is very important. Meaningful test results will allow the operators to evaluate network performanceof any shortcomings and to better plan for network upgrade. Due to the diverse and mainly unquantifiable nature of network testing results, there is a needs to develop a method for systematically and rigorously analysing these results. In this paper, we present STAM (System Test-result Analysis Method which employs a bottom-up hierarchical processing approach using Fuzzy logic. STAM is capable of combining all test results into a quantitative description of the network performance in terms of network stability, the significance of various network erros, performance of each function blocks within the network. The validity of this method has been successfully demonstrated in assisting the testing of a VoIP system at the Research Instiute of Post and Telecoms in Vietnam. The paper is organized as follows. The first section gives an overview of fuzzy logic theory the concepts of which will be used in the development of STAM. The next section describes STAM. The last section, demonstrating STAM’s capability, presents a success story in which STAM is successfully applied.

  11. Uprated OMS Engine Status-Sea Level Testing Results

    Science.gov (United States)

    Bertolino, J. D.; Boyd, W. C.

    1990-01-01

    The current Space Shuttle Orbital Maneuvering Engine (OME) is pressure fed, utilizing storable propellants. Performance uprating of this engine, through the use of a gas generator driven turbopump to increase operating pressure, is being pursued by the NASA Johnson Space Center (JSC). Component level design, fabrication, and test activities for this engine system have been on-going since 1984. More recently, a complete engine designated the Integrated Component Test Bed (ICTB), was tested at sea level conditions by Aerojet. A description of the test hardware and results of the sea level test program are presented. These results, which include the test condition operating envelope and projected performance at altitude conditions, confirm the capability of the selected Uprated OME (UOME) configuration to meet or exceed performance and operational requirements. Engine flexibility, demonstrated through testing at two different operational mixture ratios, along with a summary of projected Space Shuttle performance enhancements using the UOME, are discussed. Planned future activities, including ICTB tests at simulated altitude conditions, and recommendations for further engine development, are also discussed.

  12. Local recurrence after laparoscopic radiofrequency ablation of malignant liver tumors: Results of a contemporary series.

    Science.gov (United States)

    Takahashi, Hideo; Akyuz, Muhammet; Aksoy, Erol; Karabulut, Koray; Berber, Eren

    2017-06-01

    The aims of this study were to determine the incidence of Local recurrence (LR) in patients at long-term follow-up after laparoscopic RFA (LRFA) and also to determine the risk factors for LR from a contemporary series. Patients undergoing LRFA between 2005 and 2014 by a single surgeon were reviewed. Demographic and perioperative data were analyzed from a prospective database. LRFA was performed on 316 patients with 901 lesions. Median follow-up was 25 months, with 76% of whom completed at least one year of follow-up. The LR rate was 18.4%. The LR in patients followed for less than 12 months was 13.8%, 20.3% for 12 months, and 19.7% for 18 months (P = 0.02). One-fourth of the LRs developed after the 1st year. Morbidity was 8.9% and mortality 0.3%. Tumor type, size, ablation margin, and surgeon experience affected LR, with tumor type, size, and ablation margin being independent. This study shows that 14% of malignant liver tumors will develop LR within a year after LRFA. Additional 4% of the lesions will demonstrate recurrence within 1 cm of the ablation zone, mostly as part of a multifocal recurrence. Ablation margin is the only parameter that the surgeon can manipulate to decrease LR. © 2017 Wiley Periodicals, Inc.

  13. Cement/bentonite interaction. Results from 16 month laboratory tests

    Energy Technology Data Exchange (ETDEWEB)

    Karnland, O. [Clay Technology AB, Lund (Sweden)

    1997-12-01

    The work concerns possible bentonite clay mineral alteration in constructions with bentonite in close contact with cement, and the effect of such changes on bentonite buffer properties. The investigation comprises a 16 months laboratory test series with hydrothermal cell tests, percolation tests and diffusion tests. MX-80 Wyoming bentonite was used in all tests. Two types of artificial cement pore water solutions were used in the percolation and diffusion tests. The swelling pressure and the hydraulic conductivity were measured continuously in the percolation tests. After termination, the clay was analyzed with respect to changes in element distribution, mineralogy and shear strength. The water solutions were analyzed with respect to pH, cations and major anions. The results concerning chemical and mineralogical changes are in summary: Ion exchange in the montmorillonite until equilibrium with cement pore-water ions was reached; Increase in cation exchange capacity; Dissolution of original cristobalite; Increase in quartz content; Minor increase in illite content; Minor formation of chlorite; Formation of CSH(I); Wash away of CSH-gel into surrounding water. A large decrease in swelling pressure and a moderate increase in hydraulic conductivity were recorded in the samples percolated by SULFACEM pore-water solution. The mineralogical alterations only concerned a minor part of the total bentonite mass and the changes in physical properties were therefore most likely due to the replacement of the original charge balancing cation by cement pore-water cations. Comparisons between the current test result and results from 4 month tests indicate that the rates of illite and chlorite formation were reduced during the tests. The presence of zeolites in the clay could not be ensured. However, the discovery of CSH material is important since CSH is expected to precede the formation of zeolites 5 refs, 48 figs, 11 tabs

  14. ExEP yield modeling tool and validation test results

    Science.gov (United States)

    Morgan, Rhonda; Turmon, Michael; Delacroix, Christian; Savransky, Dmitry; Garrett, Daniel; Lowrance, Patrick; Liu, Xiang Cate; Nunez, Paul

    2017-09-01

    EXOSIMS is an open-source simulation tool for parametric modeling of the detection yield and characterization of exoplanets. EXOSIMS has been adopted by the Exoplanet Exploration Programs Standards Definition and Evaluation Team (ExSDET) as a common mechanism for comparison of exoplanet mission concept studies. To ensure trustworthiness of the tool, we developed a validation test plan that leverages the Python-language unit-test framework, utilizes integration tests for selected module interactions, and performs end-to-end crossvalidation with other yield tools. This paper presents the test methods and results, with the physics-based tests such as photometry and integration time calculation treated in detail and the functional tests treated summarily. The test case utilized a 4m unobscured telescope with an idealized coronagraph and an exoplanet population from the IPAC radial velocity (RV) exoplanet catalog. The known RV planets were set at quadrature to allow deterministic validation of the calculation of physical parameters, such as working angle, photon counts and integration time. The observing keepout region was tested by generating plots and movies of the targets and the keepout zone over a year. Although the keepout integration test required the interpretation of a user, the test revealed problems in the L2 halo orbit and the parameterization of keepout applied to some solar system bodies, which the development team was able to address. The validation testing of EXOSIMS was performed iteratively with the developers of EXOSIMS and resulted in a more robust, stable, and trustworthy tool that the exoplanet community can use to simulate exoplanet direct-detection missions from probe class, to WFIRST, up to large mission concepts such as HabEx and LUVOIR.

  15. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice

    DEFF Research Database (Denmark)

    Yuan, Haixin; Zhang, Hong; Wu, Xunwei

    2009-01-01

    Cdc42, a member of the Rho guanosine triphosphatase (GTPase) family, plays important roles in the regulation of the cytoskeleton, cell proliferation, cell polarity, and cellular transport, but little is known about its specific function in mammalian liver. We investigated the function of Cdc42...... in regulating liver regeneration. Using a mouse model with liver-specific knockout of Cdc42 (Cdc42LK), we studied liver regeneration after partial hepatectomy. Histological analysis, immunostaining, and western blot analysis were performed to characterize Cdc42LK livers and to explore the role of Cdc42 in liver...... regeneration. In control mouse livers, Cdc42 became activated between 3 and 24 hours after partial hepatectomy. Loss of Cdc42 led to a significant delay of liver recovery after partial hepatectomy, which was associated with reduced and delayed DNA synthesis indicated by 5-bromo-2'-deoxyuridine staining...

  16. Results from Testing of Two Rotary Percussive Drilling Systems

    Science.gov (United States)

    Kriechbaum, Kristopher; Brown, Kyle; Cady, Ian; von der Heydt, Max; Klein, Kerry; Kulczycki, Eric; Okon, Avi

    2010-01-01

    The developmental test program for the MSL (Mars Science Laboratory) rotary percussive drill examined the e ect of various drill input parameters on the drill pene- tration rate. Some of the input parameters tested were drill angle with respect to gravity and percussive impact energy. The suite of rocks tested ranged from a high strength basalt to soft Kaolinite clay. We developed a hole start routine to reduce high sideloads from bit walk. The ongoing development test program for the IMSAH (Integrated Mars Sample Acquisition and Handling) rotary percussive corer uses many of the same rocks as the MSL suite. An additional performance parameter is core integrity. The MSL development test drill and the IMSAH test drill use similar hardware to provide rotation and percussion. However, the MSL test drill uses external stabilizers, while the IMSAH test drill does not have external stabilization. In addition the IMSAH drill is a core drill, while the MSL drill uses a solid powdering bit. Results from the testing of these two related drilling systems is examined.

  17. Measurement of ability emotional intelligence: results for two new tests.

    Science.gov (United States)

    Austin, Elizabeth J

    2010-08-01

    Emotional intelligence (EI) has attracted considerable interest amongst both individual differences researchers and those in other areas of psychology who are interested in how EI relates to criteria such as well-being and career success. Both trait (self-report) and ability EI measures have been developed; the focus of this paper is on ability EI. The associations of two new ability EI tests with psychometric intelligence, emotion perception, and the Mayer-Salovey-Caruso EI test (MSCEIT) were examined. The new EI tests were the Situational Test of Emotion Management (STEM) and the Situational Test of Emotional Understanding (STEU). Only the STEU and the MSCEIT Understanding Emotions branch were significantly correlated with psychometric intelligence, suggesting that only understanding emotions can be regarded as a candidate new intelligence component. These understanding emotions tests were also positively correlated with emotion perception tests, and STEM and STEU scores were positively correlated with MSCEIT total score and most branch scores. Neither the STEM nor the STEU were significantly correlated with trait EI tests, confirming the distinctness of trait and ability EI. Taking the present results as a starting-point, approaches to the development of new ability EI tests and models of EI are suggested.

  18. Proposed Interventions to Decrease the Frequency of Missed Test Results

    Science.gov (United States)

    Wahls, Terry L.; Cram, Peter

    2009-01-01

    Numerous studies have identified that delays in diagnosis related to the mishandling of abnormal test results are an import contributor to diagnostic errors. Factors contributing to missed results included organizational factors, provider factors and patient-related factors. At the diagnosis error conference continuing medical education conference…

  19. EOL3 M0 X-ray Tomography Test Results

    CERN Document Server

    Avramidou, R; Bozhko, N; Borisov, A; Goriatchev, V; Goriatchev, S; Gushin, V; Fakhroutdinov, R; Kojine, A; Kononov, A; Larionov, A; Salomatin, Yu I; Schuh, S; Sedykh, Yu; Tchougouev, A

    2001-01-01

    Results of X-ray tomography test of EOL3 module 0 chamber is presented in the note. Peculiarities of the X-ray tomography of the chamber are discussed. Comparison of the tomography results with predictions of the production site measurements is made.

  20. Automated Testing Infrastructure and Result Comparison for Geodynamics Codes

    Science.gov (United States)

    Heien, E. M.; Kellogg, L. H.

    2013-12-01

    The geodynamics community uses a wide variety of codes on a wide variety of both software and hardware platforms to simulate geophysical phenomenon. These codes are generally variants of finite difference or finite element calculations involving Stokes flow or wave propagation. A significant problem is that codes of even low complexity will return different results depending on the platform due to slight differences in hardware, software, compiler, and libraries. Furthermore, changes to the codes during development may affect solutions in unexpected ways such that previously validated results are altered. The Computational Infrastructure for Geodynamics (CIG) is funded by the NSF to enhance the capabilities of the geodynamics community through software development. CIG has recently done extensive work in setting up an automated testing and result validation system based on the BaTLab system developed at the University of Wisconsin, Madison. This system uses 16 variants of Linux and Mac platforms on both 32 and 64-bit processors to test several CIG codes, and has also recently been extended to support testing on the XSEDE TACC (Texas Advanced Computing Center) Stampede cluster. In this work we overview the system design and demonstrate how automated testing and validation occurs and results are reported. We also examine several results from the system from different codes and discuss how changes in compilers and libraries affect the results. Finally we detail some result comparison tools for different types of output (scalar fields, velocity fields, seismogram data), and discuss within what margins different results can be considered equivalent.

  1. Electromagnetic results of the Japanese LCT coil's domestic test

    International Nuclear Information System (INIS)

    Nishi, Masataka; Okuno, Kiyoshi; Takahashi, Yoshikazu; Tsuji, Hiroshi; Ando, Toshinari; Shimamoto, Susumu

    1984-01-01

    The domestic test of the Japanese LCT coil was carried out in 1982. During this test, the coil was charged up to the single coil's 100% state (10.22kA, 6.4T, 106MJ) four times and experienced no quenche. at the 100% charging state, coil stability was tested by using heaters installed in the conductor. A half turn length normal zone (about 5 m) generated by heaters was spontenously disappeared in 2 second. This normalized zone included the highest magnetic field position. The transport current which gives the stable limit is extraporated to be about 12.5kA at 8T by this test result. The dump test was carried out also from the 100% charging state. At that time, about 90% of the coil's stored energy was extracted by the dump resistor and the coil was not damaged. (author)

  2. Test results and operational characteristics of prototype SSCL half cell

    International Nuclear Information System (INIS)

    McInturff, A.D.; Burgett, W.; Carter, H.

    1994-01-01

    The SSCL Accelerator System's String Test (ASST) has had several cool down, subsequent operational test series, and warm up cycles. The first cycle of these was rather limited in scope as mandated by Congress. The subsequent tests have been performed to obtain more complete information about parameters of, or operating experience with, the ensemble of magnets and spools when operating serially as in accelerator operations. The tests and procedures performed to date have emphasized cryogenic, mechanical, and electrical operations. These have included running, as well as upset conditions, i.e., superconducting to normal transition of the string (quench). This paper represents a summary of the operational test results and characteristics seen to date. A limited discussion will be included as to their implications with respect to a successful accelerator operation

  3. Depressurisation studies. Phase 2: results of Tests 127 and 128

    International Nuclear Information System (INIS)

    Edwards, A.R.; Borgartz, B.O.; Goodman, R.M.E.; O'Brien, T.P.; Rawlingson, M.

    1978-06-01

    A basic experimental programme involving the sudden depressurisation of a simple pipe system containing water at 3.45 to 17.24MPa pressure and temperature in the range of 200 to 250 0 C has been concluded. Measurements were made of the transient density, pressure, and temperature variations in a two phase fluid in the system during discharge. Phase 1 tests investigated blowdown from straight pipes 4m long with constant internal diameters of 73 and 32 mm. Phase 2 tests incorporated a reservoir added to the 32mm pipe. In this, the second of three reports on Phase 2 tests, the test assembly, instrumentation and experimental procedure are briefly described. The conditions and results are reported for two of the tests in which the liquid in the long discharge pipe was initially subcooled by 10 0 C and 15 0 C while the reservoir was at saturation conditions with a steam dome present. (UK)

  4. Resultados do transplante hepático em portadores de hepatocarcinoma Results of orthotopic liver transplantation for hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Mônica Beatriz PAROLIN

    2001-10-01

    hepatocarcinoma em fase inicial. Com seleção adequada, o transplante hepático oferece excelentes índices de sobrevida livre de recurrência tumoral.Background - Hepatocellular carcinoma is one of the most common malignancies worldwide. Liver transplantation has emerged as a good option for early-stage hepatocellular carcinoma yielding survival rates as good as for recipients without this type of tumor. Objective - To assess the outcome of cirrhotic patients with hepatocellular carcinoma undergoing liver transplantation at the Liver Transplantation Service of the "Hospital de Clínicas", Federal University of Paraná, Curitiba, PR, Brazil. Methods - Retrospective study of cirrhotic patients with hepatocellular carcinoma undergoing orthotopic liver transplantation at the mentioned Institution between September 1991 and September 2000. The diagnosis of hepatocellular carcinoma was established during the pretransplant workup in five patients and the tumor was an incidental finding in the native liver in three. The indication for liver transplantation was restricted to solitary tumor equal to or less than 5 cm or up to 3 nodules, with each nodule measuring less than 3 cm, and no evidence of vascular invasion or extrahepatic spread. Patient survival and evidence of tumoral recurrence posttransplant were evaluated. Results - The most common cause for pretransplantation liver disease was hepatitis C virus (50%. On examination of the explanted liver, the majority of patients (6/8, 75% had a single lesion; one patient had two nodules and one had a multifocal hepatocellular carcinoma found incidentally in the native liver. Tumor size ranged from 0,2 to 5,0 cm. All cases had neither vascular invasion nor linfonodal envolvement. All patients remained alive and free of tumor recurrence at the time of the study with a mean follow-up of 18,5 months (range, 5-29 months. Conclusion - Liver transplantation is a good therapeutic option for early stage hepatocellular carcinoma arising in

  5. Tensile and fracture toughness test results of neutron irradiated beryllium

    Energy Technology Data Exchange (ETDEWEB)

    Chaouadi, R.; Moons, F.; Puzzolante, J.L. [Centre d`Etude de l`Energie Nucleaire, Mol (Belgium)

    1998-01-01

    Tensile and fracture toughness test results of four Beryllium grades are reported here. The flow and fracture properties are investigated by using small size tensile and round compact tension specimens. Irradiation was performed at the BR2 material testing reactor which allows various temperature and irradiation conditions. The fast neutron fluence (>1 MeV) ranges between 0.65 and 2.45 10{sup 21} n/cm{sup 2}. In the meantime, un-irradiated specimens were aged at the irradiation temperatures to separate if any the effect of temperature from irradiation damage. Test results are analyzed and discussed, in particular in terms of the effects of material grade, test temperature, thermal ageing and neutron irradiation. (author)

  6. COMPARISON OF RESULTS OF THERMAL TESTS OF BALCONY DOORS

    Directory of Open Access Journals (Sweden)

    Golubev Stanislav Sergeevich

    2012-10-01

    Full Text Available Results of thermal tests of balcony doors are presented in the article. In the course of the research project, two types of doors were tested. The first type represents a PVC frame door (width 82 mm; it has a triple glazing (4K-16Ar-4-16Ar-K4; its blank part represents a polystyrene sandwich panel (width 40 mm. The second type represents a PVC frame door (width 82 mm, that has a triple glazing (4K-16Ar-4-16Ar-K4 and composite PVC panels. The testing procedure and processing results are described in the article. The test has demonstrated that the thermal resistance value of the balcony door of the first type exceeds the thermal resistance value of the balcony door of the second type.

  7. Utility of the ELF Test for Detecting Steatohepatitis in Morbid Obese Patients with Suspicion of Nonalcoholic Fatty Liver Disease.

    Science.gov (United States)

    López, Iria Cebreiros; Aroca, Florentina Guzmán; Bernal, Maria Dolores Frutos; Mompeán, Juan Antonio Luján; Bernal, Águeda Bas; Martínez, Antonio Miguel Hernández; Barba, Enrique Martínez; Velasco, Jose Antonio Noguera; Paricio, Pascual Parilla

    2017-09-01

    Morbid obese patients have a high rate of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). NASH is related to the progression and poor evolution of chronic hepatopathy in NAFLD, so that its detection makes it possible to identify the subjects who are most at risk in order to prioritize treatment. The ELF test (Enhanced Liver Fibrosis test; Siemens Diagnostics, NY, USA) has been assessed for its capacity to detect fibrosis in patients with NAFLD, but its capacity for diagnosing NASH has not been checked. Our objective is to determine the utility of the ELF test for detecting NASH in morbid obese patients with suspected NAFLD. ELF values were determined in a cohort of obese patients who underwent bariatric surgery with suspected NAFLD. Liver biopsy was used as the reference standard. The values of ELF were significantly higher in patients with NASH (p = 0.002) and in those who presented with metabolic syndrome (p = 0.047). An ELF cut-off point of 8.72 allows the detection of patients with NASH with a sensitivity of 71.4% and a specificity of 74.1% (AUC = 0.742, p = 0.002). The ELF test is efficient for the identification of obese patients with NAFLD and early signs of steatohepatitis and fibrosis.

  8. Analysis of SCTF/CCTF counterpart test results

    International Nuclear Information System (INIS)

    Okubo, Tsutomu; Sobajima, Makoto; Iwamura, Takamichi; Ohnuki, Akira; Abe, Yutaka; Adachi, Hiromichi; Murao, Yoshio

    1990-06-01

    Slab Core Test Facility (SCTF) and Cylindrical Core Test Facility (CCTF) are large scale experimental facilities of Japan Atomic Energy Research Institute (JAERI) for the investigation of reflooding behavior during a postulated loss-of-coolant accident (LOCA) in PWRs. Although the flow area scaling ratios of both facilities to a 1,000 MWe class PWR are the same and 1/21.4, the SCTF has the same core width as the radius of the reference PWR while the CCTF has a 1/4.5 times shorter core radius. Therefore, a few SCTF/CCTF counterpart tests were conducted in order to investigate the difference in core reflooding behavior between in the SCTF and CCTF tests as well as the effect of core radial length on core two-dimensional thermo-hydrodynamic behavior. This report present the test results and an analysis on them. Major results obtained are: (1) Taking account of the differences in test conditions and facility design, core reflooding behavior is considered to be similar between the SCTF and the CCTF test. Main difference of the facility design is in the effective core flow area and this is considered to result in the difference in core water accumulation behavior. (2) The effect of core radial length on core two-dimensional thermo-hydrodynamic behavior has been observed to be significant and heat transfer enhancement or degradation in radial direction is more significant for the longer radius core. (3) In addition, where the core power varies significantly in the radial direction, significant heat transfer enhancement has been observed in the higher power bundle during the LPCI period. Also, in the peripheral region, heat transfer degradation has been observed more significantly in the outer bundle even they have the same bundle power. (4) Magnitude of these heat transfer enhancement or degradation was larger at the higher elevation than the midplane level in the SCTF test, whereas smaller in the CCTF test. (author)

  9. Improved PFB operations - 400-hour turbine test results

    Science.gov (United States)

    Rollbuhler, R. J.; Benford, S. M.; Zellars, G. R.

    1980-04-01

    The paper deals with a 400-hr small turbine test in the effluent of a pressurized fluidized bed (PFB) at an average temperature of 770 C, an average relative gas velocity of 300 m/sec, and average solid loadings of 200 ppm. Consideration is given to combustion parameters and operating procedure as well as to the turbine system and turbine test operating procedures. Emphasis is placed on erosion/corrosion results.

  10. Test Beam Results of a 3D Diamond Detector

    CERN Document Server

    Dunser, Marc

    2015-01-01

    3D pixel technology has been used successfully in the past with silicon detectors for tracking applications. Recently, a first prototype of the same 3D technology has been produced on a chemical vapour deposited single-crystal diamond sensor. This device has been subsequently tested in a beam test at CERN’s SPS accelerator in a beam of 120 GeV protons. Details on the production and results of testbeam data are presented.

  11. Creep in rock salt with temperature. Testing methods and results

    International Nuclear Information System (INIS)

    Charpentier, J.P.; Berest, P.

    1985-01-01

    The growing interest shown in the delayed behaviour of rocks at elevated temperature has led the Solid Mechanics Laboratory to develop specific equipment designed for creep tests. The design and dimensioning of these units offer the possibility of investigating a wide range of materials. The article describes the test facilities used (uni-axial and tri-axial creep units) and presents the experimental results obtained on samples of Bresse salt [fr

  12. Acoustic results of the Boeing model 360 whirl tower test

    Science.gov (United States)

    Watts, Michael E.; Jordan, David

    1990-09-01

    An evaluation is presented for whirl tower test results of the Model 360 helicopter's advanced, high-performance four-bladed composite rotor system intended to facilitate over-200-knot flight. During these performance measurements, acoustic data were acquired by seven microphones. A comparison of whirl-tower tests with theory indicate that theoretical prediction accuracies vary with both microphone position and the inclusion of ground reflection. Prediction errors varied from 0 to 40 percent of the measured signal-to-peak amplitude.

  13. Results of initial nuclear tests on LWBR (LWBR Development Program)

    International Nuclear Information System (INIS)

    Sarber, W.K.

    1979-06-01

    This report presents and discusses the results of physics tests performed at beginning of life on the Light Water Breeder Reactor (LWBR). These tests have confirmed that movable seed assembly critical positions and reactivity worths, temperature coefficients, xenon transient characteristics, core symmetry, and core shutdown are within the range of values used in the design of the LWBR and its reactor protection analysis. Measured core physics parameters were found to be in good agreement with the calculated values

  14. Wellbore inertial navigation system (WINS) software development and test results

    Energy Technology Data Exchange (ETDEWEB)

    Wardlaw, R. Jr.

    1982-09-01

    The structure and operation of the real-time software developed for the Wellbore Inertial Navigation System (WINS) application are described. The procedure and results of a field test held in a 7000-ft well in the Nevada Test Site are discussed. Calibration and instrumentation error compensation are outlined, as are design improvement areas requiring further test and development. Notes on Kalman filtering and complete program listings of the real-time software are included in the Appendices. Reference is made to a companion document which describes the downhole instrumentation package.

  15. Construction details and test results from RHIC sextupoles

    International Nuclear Information System (INIS)

    Lindner, M.; Anerella, M.; Ganetis, G.

    1993-01-01

    Four 8 cm aperture sextupoles have been built at BNL to verify the magnetic performance of this magnet in the RHIC installation. Two significantly different mechanical configurations have been designed, and two magnets of each design have been built, and successfully tested, and have exceeded the required minimum quench current by a substantial margin. This report describes the assembly details of the second configuration, which is the final production configuration. In addition the first industry built production sextupole has been delivered and tested. This report presents the results of quench tests on all 5 magnets and field measurements on the first production sextupole

  16. Advanced Stirling Convertor Durability Testing: Plans and Interim Results

    Science.gov (United States)

    Meer, David W.; Oriti, Salvatore M.

    2012-01-01

    The U.S. Department of Energy (DOE), Lockheed Martin Corporation (LM), and NASA Glenn Research Center (GRC) have been developing the Advanced Stirling Radioisotope Generator (ASRG) for use as a power system for space science missions. In support of this program, GRC has been involved in testing Stirling convertors, including the Advanced Stirling Convertor (ASC), for use in the ASRG. This testing includes electromagnetic interference/compatibility (EMI/EMC), structural dynamics, advanced materials, organics, and unattended extended operation. The purpose of the durability tests is to experimentally demonstrate the margins in the ASC design. Due to the high value of the hardware, previous ASC tests focused on establishing baseline performance of the convertors within the nominal operating conditions. The durability tests present the first planned extension of the operating conditions into regions beyond those intended to meet the product spec, where the possibility exists of lateral contact, overstroke, or over-temperature events. These tests are not intended to cause damage that would shorten the life of the convertors, so they can transition into extended operation at the conclusion of the tests. This paper describes the four tests included in the durability test sequence: 1) start/stop cycling, 2) exposure to constant acceleration in the lateral and axial directions, 3) random vibration at increased piston amplitude to induce contact events, and 4) overstroke testing to simulate potential failures during processing or during the mission life where contact events could occur. The paper also summarizes the analysis and simulation used to predict the results of each of these tests.

  17. Results of patch testing in 10 patients with peristomal dermatitis.

    Science.gov (United States)

    Landis, Megan N; Keeling, James H; Yiannias, James A; Richardson, Donna M; Nordberg Linehan, Diane L; Davis, Mark D P

    2012-09-01

    Peristomal dermatitis is a common problem in patients with ostomies that is a source of considerable morbidity. Irritant contact dermatitis is most common, but allergic contact dermatitis can also occur. Because of the lack of published reports on patch testing for this indication, we undertook a retrospective study of patch testing results in patients with suspected peristomal allergic contact dermatitis. We sought to describe our patch testing experience with patients referred with peristomal dermatitis. This was a retrospective review of medical records of patients with ostomies and peristomal dermatitis who underwent patch testing in the Mayo Clinic Departments of Dermatology in Jacksonville, FL; Rochester, MN; and Scottsdale, AZ, during a 10-year period (2000-2010). Ten patients with peristomal dermatitis were referred for patch testing (6 in Minnesota, 2 in Florida, and 2 in Arizona). Patients were patch tested to the materials used in their stoma devices, to the standard series, and in some cases to supplemental series. All 10 had at least one allergic patch test reaction, most commonly to stoma paste (3 of 10 patients). Retrospective nature of study via chart review is a limitation. Patch testing is a useful tool for identification of allergens in patients with peristomal dermatitis. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  18. Physical separations soil washing system cold test results

    Energy Technology Data Exchange (ETDEWEB)

    McGuire, J.P.

    1993-07-28

    This test summary describes the objectives, methodology, and results of a physical separations soil-washing system setup and shakedown test using uncontaminated soil. The test is being conducted in preparation for a treatability test to be conducted in the North Pond of the 300-FF-1 Operable Unit. It will be used to assess the feasibility of using a physical separations process to reduce the volume of contaminated soils in the 300-FF-1 Operable Unit. The test is described in DOE-RL (1993). The setup test was conducted at an uncontrolled area located approximately 3.2 km northwest of the 300-FF-1 Operable Unit. The material processed was free of contamination. The physical separation equipment to be used in the test was transferred to the US Department of Energy (DOE) by the US Environmental Protection Agency (EPA) Risk Reduction Engineering Laboratory. On May 13, 1993, soil-washing equipment was moved to the cold test location. Design assistance and recommendation for operation was provided by the EPA.

  19. LWR surveillance dosimetry improvement program: PSF metallurgical blind test results

    International Nuclear Information System (INIS)

    Kam, F.B.K.; Stallmann, F.W.; Guthrie, G.; McElroy, W.N.

    1985-01-01

    The ORR-PSF benchmark experiment was designed to simulate the surveillance capsule-pressure vessel configuration in power reactors and to test the validity of procedures which determine the radiation damage in the vessel from test results in the surveillance capsule. The PSF metallurgical blind test was initiated to give participants an opportunity to test their current embrittlement prediction methodologies. Experimental results were withheld from the participants except for the type of information which is normally contained in surveillance reports. Preliminary analysis of the PSF metallurgical blind test results shows that: (1) current prediction methodologies, as used by the PSF Blind Test participants, are adequate, falling within +- 20 0 C of the measured values for Δ NDT. None of the different methods is clearly superior; (2) the proposed revision of Reg. Guide 1.99 (Rev. 2) gives a better representation of the fluence and chemistry dependency of Δ NDT than the current version (Rev. 1); and (3) fluence rate effects can be seen but not quantified. Fluence spectral effects are too small to be detectable in this experiment. (orig.)

  20. Thermal Analysis of Low Layer Density Multilayer Insulation Test Results

    Science.gov (United States)

    Johnson, Wesley L.

    2011-01-01

    Investigation of the thermal performance of low layer density multilayer insulations is important for designing long-duration space exploration missions involving the storage of cryogenic propellants. Theoretical calculations show an analytical optimal layer density, as widely reported in the literature. However, the appropriate test data by which to evaluate these calculations have been only recently obtained. As part of a recent research project, NASA procured several multilayer insulation test coupons for calorimeter testing. These coupons were configured to allow for the layer density to be varied from 0.5 to 2.6 layer/mm. The coupon testing was completed using the cylindrical Cryostat-l00 apparatus by the Cryogenics Test Laboratory at Kennedy Space Center. The results show the properties of the insulation as a function of layer density for multiple points. Overlaying these new results with data from the literature reveals a minimum layer density; however, the value is higher than predicted. Additionally, the data show that the transition region between high vacuum and no vacuum is dependent on the spacing of the reflective layers. Historically this spacing has not been taken into account as thermal performance was calculated as a function of pressure and temperature only; however the recent testing shows that the data is dependent on the Knudsen number which takes into account pressure, temperature, and layer spacing. These results aid in the understanding of the performance parameters of MLI and help to complete the body of literature on the topic.

  1. Clinical Trial Results Summary for Laypersons: A User Testing Study.

    Science.gov (United States)

    Raynor, D K; Myers, L; Blackwell, K; Kress, B; Dubost, A; Joos, A

    2018-01-01

    To apply "user testing" to maximize readability and acceptability of a Clinical Trial Results Laypersons Summary-a new European requirement. "User testing" (using questionnaire and semistructured interview) assessed whether people could find and understand key points. Findings were used to improve content and design, prior to retesting. Participants had a range of levels of health literacy and there was a higher education group. Participants accessed the summary on screen. In round 1 we tested 12 points of information. In round 2 a revised summary addressing round 1 findings was tested, leading to a third final version. In round 1, 2 of 12 points of information did not reach the target and interviews raised further format and content issues (some distracting technical explanations and inability to find or understand the 2 main study purposes). These findings informed revisions for the version tested in round 2, with 2 different points not reaching the target (inclusion criteria relating to duration of seasonal allergies and how researchers found out about participants' symptoms). Identified problems in both rounds were addressed and reflected in the final version. Despite improvements, participants did not consistently understand that summaries were intended for the public, or to only interpret results of single trials in the context of additional trials. All readers, including those with higher education, found the clear and straightforward language acceptable. Applying "user testing" resulted in a largely health-literate summary suitable for people across a range of backgrounds.

  2. Autoimmune liver disease panel

    Science.gov (United States)

    Liver disease test panel - autoimmune ... Autoimmune disorders are a possible cause of liver disease. The most common of these diseases are autoimmune hepatitis and primary biliary cholangitis (formerly called primary biliary cirrhosis). This group of tests ...

  3. Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.

    Directory of Open Access Journals (Sweden)

    Ben C L van Schaijk

    Full Text Available Difficulties with inducing sterile and long lasting protective immunity against malaria with subunit vaccines has renewed interest in vaccinations with attenuated Plasmodium parasites. Immunizations with sporozoites that are attenuated by radiation (RAS can induce strong protective immunity both in humans and rodent models of malaria. Recently, in rodent parasites it has been shown that through the deletion of a single gene, sporozoites can also become attenuated in liver stage development and, importantly, immunization with these sporozoites results in immune responses identical to RAS. The promise of vaccination using these genetically attenuated sporozoites (GAS depends on translating the results in rodent malaria models to human malaria. In this study, we perform the first essential step in this transition by disrupting, p52, in P. falciparum an ortholog of the rodent parasite gene, p36p, which we had previously shown can confer long lasting protective immunity in mice. These P. falciparum P52 deficient sporozoites demonstrate gliding motility, cell traversal and an invasion rate into primary human hepatocytes in vitro that is comparable to wild type sporozoites. However, inside the host hepatocyte development is arrested very soon after invasion. This study reveals, for the first time, that disrupting the equivalent gene in both P. falciparum and rodent malaria Plasmodium species generates parasites that become similarly arrested during liver stage development and these results pave the way for further development of GAS for human use.

  4. Spent fuel drying system test results (first dry-run)

    International Nuclear Information System (INIS)

    Klinger, G.S.; Oliver, B.M.; Abrefah, J.; Marschman, S.C.; MacFarlan, P.J.; Ritter, G.A.

    1998-07-01

    The water-filled K-Basins in the Hanford 100 Area have been used to store N-Reactor spent nuclear fuel (SNF) since the 1970s. Because some leaks in the basin have been detected and some of the fuel is breached due to handling damage and corrosion, efforts are underway to remove the fuel elements from wet storage. An Integrated Process Strategy (IPS) has been developed to package, dry, transport, and store these metallic uranium fuel elements in an interim storage facility on the Hanford Site. Information required to support the development of the drying processes, and the required safety analyses, is being obtained from characterization tests conducted on fuel elements removed from the K-Basins. A series of whole element drying tests (reported in separate documents, see Section 7.0) have been conducted by Pacific Northwest National Laboratory (PNNL) on several intact and damaged fuel elements recovered from both the K-East and K-West Basins. This report documents the results of the first dry-run test, which was conducted without a fuel element. The empty test apparatus was subjected to a combination of low- and high-temperature vacuum drying treatments that were intended to mimic, wherever possible, the fuel treatment strategies of the IPS. The data from this dry-run test can serve as a baseline for the first two fuel element tests, 1990 (Run 1) and 3128W (Run 2). The purpose of this dry-run was to establish the background levels of hydrogen in the system, and the hydrogen generation and release characteristics attributable to the test system without a fuel element present. This test also serves to establish the background levels of water in the system and the water release characteristics. The system used for the drying test series was the Whole Element Furnace Testing System, described in Section 2.0, which is located in the Postirradiation Testing Laboratory (PTL, 327 Building). The test conditions and methodology are given in section 3.0, and the experimental

  5. Small-Scale Spray Releases: Initial Aerosol Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Mahoney, Lenna A.; Gauglitz, Phillip A.; Kimura, Marcia L.; Brown, Garrett N.; Kurath, Dean E.; Buchmiller, William C.; Smith, Dennese M.; Blanchard, Jeremy; Song, Chen; Daniel, Richard C.; Wells, Beric E.; Tran, Diana N.; Burns, Carolyn A.

    2013-05-29

    One of the events postulated in the hazard analysis at the Waste Treatment and Immobilization Plant (WTP) and other U.S. Department of Energy (DOE) nuclear facilities is a breach in process piping that produces aerosols with droplet sizes in the respirable range. The current approach for predicting the size and concentration of aerosols produced in a spray leak involves extrapolating from correlations reported in the literature. These correlations are based on results obtained from small engineered spray nozzles using pure liquids with Newtonian fluid behavior. The narrow ranges of physical properties on which the correlations are based do not cover the wide range of slurries and viscous materials that will be processed in the WTP and across processing facilities in the DOE complex. Two key technical areas were identified where testing results were needed to improve the technical basis by reducing the uncertainty due to extrapolating existing literature results. The first technical need was to quantify the role of slurry particles in small breaches where the slurry particles may plug and result in substantially reduced, or even negligible, respirable fraction formed by high-pressure sprays. The second technical need was to determine the aerosol droplet size distribution and volume from prototypic breaches and fluids, specifically including sprays from larger breaches with slurries where data from the literature are scarce. To address these technical areas, small- and large-scale test stands were constructed and operated with simulants to determine aerosol release fractions and net generation rates from a range of breach sizes and geometries. The properties of the simulants represented the range of properties expected in the WTP process streams and included water, sodium salt solutions, slurries containing boehmite or gibbsite, and a hazardous chemical simulant. The effect of antifoam agents was assessed with most of the simulants. Orifices included round holes and

  6. The CANopen Controller IP Core: Implementation, Synthesis and Test Results

    Science.gov (United States)

    Caramia, Maurizio; Bolognino, Luca; Montagna, Mario; Tosi, Pietro; Errico, Walter; Bigongiari, Franco; Furano, Gianluca

    2011-08-01

    This paper will describe the implementation and test results of the CANopen Controller IP Core (CCIPC) implemented by Thales Alenia Space and SITAEL Aerospace with the support of ESA in the frame of the EXOMARS Project. The CCIPC is a configurable VHDL implementation of the CANOPEN protocol [1]; it is foreseen to be used as CAN bus slave controller within the EXOMARS Entry Descending and Landing Demonstrato Module (EDM) and Rover Module. The CCIPC features, configuration capability, synthesis and test results will be described and the evidence of the state of maturity of this innovative IP core will be demonstrated.

  7. Large coil task and results of testing US coils

    International Nuclear Information System (INIS)

    Haubenreich, P.N.

    1986-01-01

    The United States, EURATOM, Japan, and Switzerland have collaborated since 1978 in development of superconducting toroidal field coils for fusion reactor applications. The United States provided a test facility nd three coils; the other participants, one coil each. All coils have the same interface dimensions and performance requirements (stable at 8 T), but internal design was decided by each team. Two US coil teams chose bath-cooled NbTi, 10-kA conductors. One developed a Nb 3 Sn conductor, cooled by internal flow, rated at 18 kA. All US coils have diagnostic instrumentation and imbedded heaters that enable stability tests and simulated nuclear heating experiments. In single-coil tests, each coil operated at full current in self-field (6.4 T). In six-coil tests that began in July 1986, one US coil and the Japanese coil hve been successfully operated at full current at 8 T. The other coils have operated as background coils while awaiting their turn as test coil. Coil tests have been informative and results gratifying. The facility has capably supported coil testing and its operation has provided information that will be useful in designing future fusion systems. Coil capabilities beyond nominal design points will be determined

  8. Healthy Efficient New Gas Homes (HENGH) Pilot Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Wanyu R. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Maddalena, Randy L [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Stratton, Chris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hotchi, Toshifumi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singer, Brett C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walker, Iain S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sherman, Max H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-05-01

    The Healthy Efficient New Gas Homes (HENGH) is a field study that will collect data on ventilation systems and indoor air quality (IAQ) in new California homes that were built to 2008 Title 24 standards. A pilot test was performed to help inform the most time and cost effective approaches to measuring IAQ in the 100 test homes that will be recruited for this study. Two occupied, single-family detached homes built to 2008 Title 24 participated in the pilot test. One of the test homes uses exhaust-only ventilation provided by a continuous exhaust fan in the laundry room. The other home uses supply air for ventilation. Measurements of IAQ were collected for two weeks. Time-resolved concentrations of particulate matter (PM), nitrogen dioxide (NO2), carbon dioxide (CO2), carbon monoxide (CO), and formaldehyde were measured. Measurements of IAQ also included time-integrated concentrations of volatile organic compounds (VOCs), volatile aldehydes, and NO2. Three perfluorocarbon tracers (PFTs) were used to estimate the dilution rate of an indoor emitted air contaminant in the two pilot test homes. Diagnostic tests were performed to measure envelope air leakage, duct leakage, and airflow of range hood, exhaust fans, and clothes dryer vent when accessible. Occupant activities, such as cooking, use of range hood and exhaust fans, were monitored using various data loggers. This document describes results of the pilot test.

  9. Test results of the SMES model coil. Pulse performance

    International Nuclear Information System (INIS)

    Hamajima, Takataro; Shimada, Mamoru; Ono, Michitaka

    1998-01-01

    A model coil for superconducting magnetic energy storage (SMES model coil) has been developed to establish the component technologies needed for a small-scale 100 kWh SMES device. The SMES model coil was fabricated, and then performance tests were carried out in 1996. The coil was successfully charged up to around 30 kA and down to zero at the same ramp rate of magnetic field experienced in a 100 kWh SMES device. AC loss in the coil was measured by an enthalpy method as parameters of ramp rate and flat top current. The results were evaluated by an analysis and compared with short-sample test results. The measured hysteresis loss is in good agreement with that estimated from the short-sample results. It was found that the coupling loss of the coil consists of two major coupling time constants. One is a short time constant of about 200 ms, which is in agreement with the test results of a short real conductor. The other is a long time constant of about 30 s, which could not be expected from the short sample test results. (author)

  10. LWR aerosol containment experiments (LACE) program and initial test results

    International Nuclear Information System (INIS)

    Muhlestein, L.D.; Hilliard, R.K.; Bloom, G.R.; McCormack, J.D.; Rahn, F.J.

    1985-01-01

    The LWR aerosol containment experiments (LACE) program is described. The LACE program is being performed at the Hanford Engineer Development Laboratory (operated by Westinghouse Hanford Company) and the initial tests are sponsored by EPRI. The objectives of the LACE program are: to demonstrate, at large-scale, inherent radioactive aerosol retention behavior for postulated high consequence LWR accident situations; and to provide a data base to be used for aerosol behavior . Test results from the first phase of the LACE program are presented and discussed. Three large-scale scoping tests, simulating a containment bypass accident sequence, demonstrated the extent of agglomeration and deposition of aerosols occurring in the pipe pathway and vented auxiliary building under realistic accident conditions. Parameters varied during the scoping tests were aerosol type and steam condensation

  11. Selected Test Results from the Encell Technology Nickel Iron Battery

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Summer Kamal Rhodes [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Advanced Power Sources R& D; Baca, Wes Edmund [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Advanced Power Sources R& D; Avedikian, Kristan [Encell Technology, Alachua, FL (United States)

    2014-09-01

    The performance of the Encell Nickel Iron (NiFe) battery was measured. Tests included capacity, capacity as a function of rate, capacity as a function of temperature, charge retention (28-day), efficiency, accelerated life projection, and water refill evaluation. The goal of this work was to evaluate the general performance of the Encell NiFe battery technology for stationary applications and demonstrate the chemistry's capabilities in extreme conditions. Test results have indicated that the Encell NiFe battery technology can provide power levels up to the 6C discharge rate, ampere-hour efficiency above 70%. In summary, the Encell batteries have met performance metrics established by the manufacturer. Long-term cycle tests are not included in this report. A cycle test at elevated temperature was run, funded by the manufacturer, which Encell uses to predict long-term cycling performance, and which passed their prescribed metrics.

  12. Results of assembly test of HTTR reactor internals

    International Nuclear Information System (INIS)

    Maruyama, S.; Saikusa, A.; Shiozawa, S.; Tsuji, N.; Miki, T.

    1996-01-01

    The assembly test of the HTTR actual reactor internals had been carried out at the works, prior to their installation in the actual reactor pressure vessel(RPV) at the construction site. The assembly test consists of several items such as examining fabricating precision of each component and alignment of piled-up structures, measuring circumferential coolant velocity profile in the passage between the simulated RPV and the reactor internals as well as under the support plates, measuring by-pass flow rate through gaps between the reactor internals, and measuring the binding force of the core restraint mechanism. Results of the test showed good performance of the HTTR reactor internals. Installation of the reactor internals in the actual RPV was started at the construction site of HTTR in April, 1995. In the installation process, main items of the assembly test at the works were repeated to investigate the reproducibility of installation. (author). 5 refs, 11 figs

  13. Small-Scale Spray Releases: Initial Aerosol Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Mahoney, Lenna A.; Gauglitz, Phillip A.; Kimura, Marcia L.; Brown, Garrett N.; Kurath, Dean E.; Buchmiller, William C.; Smith, Dennese M.; Blanchard, Jeremy; Song, Chen; Daniel, Richard C.; Wells, Beric E.; Tran, Diana N.; Burns, Carolyn A.

    2012-11-01

    One of the events postulated in the hazard analysis at the Waste Treatment and Immobilization Plant (WTP) and other U.S. Department of Energy (DOE) nuclear facilities is a breach in process piping that produces aerosols with droplet sizes in the respirable range. The current approach for predicting the size and concentration of aerosols produced in a spray leak involves extrapolating from correlations reported in the literature. These correlations are based on results obtained from small engineered spray nozzles using pure liquids with Newtonian fluid behavior. The narrow ranges of physical properties on which the correlations are based do not cover the wide range of slurries and viscous materials that will be processed in the WTP and across processing facilities in the DOE complex. Two key technical areas were identified where testing results were needed to improve the technical basis by reducing the uncertainty due to extrapolating existing literature results. The first technical need was to quantify the role of slurry particles in small breaches where the slurry particles may plug and result in substantially reduced, or even negligible, respirable fraction formed by high-pressure sprays. The second technical need was to determine the aerosol droplet size distribution and volume from prototypic breaches and fluids, specifically including sprays from larger breaches with slurries where data from the literature are scarce. To address these technical areas, small- and large-scale test stands were constructed and operated with simulants to determine aerosol release fractions and generation rates from a range of breach sizes and geometries. The properties of the simulants represented the range of properties expected in the WTP process streams and included water, sodium salt solutions, slurries containing boehmite or gibbsite, and a hazardous chemical simulant. The effect of anti-foam agents was assessed with most of the simulants. Orifices included round holes and

  14. Wind tunnel test IA300 analysis and results, volume 1

    Science.gov (United States)

    Kelley, P. B.; Beaufait, W. B.; Kitchens, L. L.; Pace, J. P.

    1987-01-01

    The analysis and interpretation of wind tunnel pressure data from the Space Shuttle wind tunnel test IA300 are presented. The primary objective of the test was to determine the effects of the Space Shuttle Main Engine (SSME) and the Solid Rocket Booster (SRB) plumes on the integrated vehicle forebody pressure distributions, the elevon hinge moments, and wing loads. The results of this test will be combined with flight test results to form a new data base to be employed in the IVBC-3 airloads analysis. A secondary objective was to obtain solid plume data for correlation with the results of gaseous plume tests. Data from the power level portion was used in conjunction with flight base pressures to evaluate nominal power levels to be used during the investigation of changes in model attitude, eleveon deflection, and nozzle gimbal angle. The plume induced aerodynamic loads were developed for the Space Shuttle bases and forebody areas. A computer code was developed to integrate the pressure data. Using simplified geometrical models of the Space Shuttle elements and components, the pressure data were integrated to develop plume induced force and moments coefficients that can be combined with a power-off data base to develop a power-on data base.

  15. Potential for false positive HIV test results with the serial rapid HIV testing algorithm

    Directory of Open Access Journals (Sweden)

    Baveewo Steven

    2012-03-01

    Full Text Available Abstract Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold. However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2% were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals.

  16. Test-beam results of a SOI pixel detector prototype

    CERN Document Server

    Bugiel, Roma; Dannheim, Dominik; Fiergolski, Adrian; Hynds, Daniel; Idzik, Marek; Kapusta, P; Kucewicz, Wojciech; Munker, Ruth Magdalena; Nurnberg, Andreas Matthias

    2018-01-01

    This paper presents the test-beam results of a monolithic pixel-detector prototype fabricated in 200 nm Silicon-On-Insulator (SOI) CMOS technology. The SOI detector was tested at the CERN SPS H6 beam line. The detector is fabricated on a 500 μm thick high-resistivity float- zone n-type (FZ-n) wafer. The pixel size is 30 μm × 30 μm and its readout uses a source- follower configuration. The test-beam data are analysed in order to compute the spatial resolution and detector efficiency. The analysis chain includes pedestal and noise calculation, cluster reconstruction, as well as alignment and η-correction for non-linear charge sharing. The results show a spatial resolution of about 4.3 μm.

  17. Guidelines to Interpret Results of Mechanical Blade Test

    International Nuclear Information System (INIS)

    Arias Vega, F.; Sanz Martin, J. C.

    1999-01-01

    This report shows the interpretation of full scale rotor blade test results and describes the engineering testing models and coefficients for any feasible rotor blade design, in order to accept and to certify any final manufactured blade as an allowable product, fit for use and working with a completely security during all the wind turbines lifetime. This work was carried out at the Wind Energy Division of the CIEMAT.DER and it is based on the authors technical experience in this field, after many years working on testing blades. Also, this paper contains results of the European wind turbine Standards II relevant to the European Project: JOULE III R.D. where the Wind Energy Division took part as participant too. (Author)

  18. Guidelines to Interpret Results of Mechanical Blade Test

    Energy Technology Data Exchange (ETDEWEB)

    Arias Vega, F.; Sanz Martin, J. C. [Ciemat, Madrid (Spain)

    2000-07-01

    This report shows the interpretation of full scale rotor blade test results and describes the engineering testing models and coefficients for any feasible rotor blade design, in order to accept and to certify any final manufactured blades as an allowable product, fit for use and working with a completely security during all the windturbine's lifetime. This work was carried out at the Wind Energy Division of the CIEMAT.DER and it is based on the author's technical experience in this field, after many years working on testing blades. Also, this paper contains results of the European wind turbine Standards II relevant to the European Project: JOULE III R.D. where the Wind Energy Division took part as participant too. (Author)

  19. Results for the Brine Evaporation Bag (BEB) Brine Processing Test

    Science.gov (United States)

    Delzeit, Lance; Flynn, Michael; Fisher, John; Shaw, Hali; Kawashima, Brian; Beeler, David; Howard, Kevin

    2015-01-01

    The recent Brine Processing Test compared the NASA Forward Osmosis Brine Dewatering (FOBD), Paragon Ionomer Water Processor (IWP), UMPQUA Ultrasonic Brine Dewatering System (UBDS), and the NASA Brine Evaporation Bag (BEB). This paper reports the results of the BEB. The BEB was operated at 70 deg C and a base pressure of 12 torr. The BEB was operated in a batch mode, and processed 0.4L of brine per batch. Two different brine feeds were tested, a chromic acid-urine brine and a chromic acid-urine-hygiene mix brine. The chromic acid-urine brine, known as the ISS Alternate Pretreatment Brine, had an average processing rate of 95 mL/hr with a specific power of 5kWhr/L. The complete results of these tests will be reported within this paper.

  20. Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.

    Directory of Open Access Journals (Sweden)

    James Fung

    Full Text Available BACKGROUND: For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. AIMS: To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease. METHODS: This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants. RESULTS: Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89. The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p55 years (p=0.001. CONCLUSIONS: The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness.

  1. Preliminary results of testing bioassay analytical performance standards

    International Nuclear Information System (INIS)

    Fisher, D.R.; Robinson, A.V.; Hadley, R.T.

    1983-08-01

    The analytical performance of both in vivo and in vitro bioassay laboratories is being studied to determine the capability of these laboratories to meet the minimum criteria for accuracy and precision specified in the draft ANSI Standard N13.30, Performance Criteria for Radiobioassay. This paper presents preliminary results of the first round of testing

  2. Pattern Of Skin Prick Allergy Test Results In Enugu | Mgbor ...

    African Journals Online (AJOL)

    In this study we report on pattern of allergy prick skin test results found among atopic patients attending the department of otorhinolargngology of the University of Nigeria Teaching Hospital Enugu and Hansa Clinics, Enugu and propose ways of minimizing the exposure of the population to allergens. Material and method

  3. Test Beam Results Obtained with the Q4 Prototype

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Benitez, M.; Alberdi, J.; Cerrada, M.; Colino, N.; Daniel, M.; Fouz, M. c.; Marin, J.; Mocholi, J.; Oller, J. C.; Puerta, J.; Romero, L.; Salicio, J. M.

    2000-07-01

    A prototype of the CMS Barrel Muon Detector incorporating all the features of the final chambers was built at CIEMAT using the mass production assembly procedures and tools. The performance of this prototype was studied in a muon test beam at CERN and the results obtained are presented here. (Author)

  4. Recent results on the RIA test in IGR reactor

    International Nuclear Information System (INIS)

    Asmolov, V.; Yegorova, L.

    1997-01-01

    At the 23d WRSM meeting the data base characterizing results of VVER high burnup fuel rods tests under reactivity-initiated accident (RIA) conditions was presented. Comparison of PWR and VVER failure thresholds was given also. Additional analysis of the obtained results was being carried out during 1996. The results of analysis show that the two different failure mechanisms were observed for PWR and VVER fuel rods. Some factors which can be as the possible reasons of these differences are presented. First of them is the state of preirradiated cladding. Published test data for PWR high burnup fuel rods demonstrated that the PWR high burnup fuel rods failed at the RIA test are characterized by very high level of oxidation and hydriding for the claddings. Corresponding researches were performed at Institute of Atomic Reactors (RLAR, Dimitrovgrad, Russia) for large set of VVER high burnup fuel rods. Results of these investigations show that preirradiated commercial Zr-1%Nb claddings practically keep their initial levels of oxidation and H 2 concentration. Consequently the VVER preirradiated cladding must keep the high level of mechanical properties. The second reason leading to differences between failure mechanisms for two types of high burnup fuel rods can be the test conditions. Now such kind of analysis have been performed by two methods

  5. Interpretation of Chemical Pathology Test Results in Paediatrics ...

    African Journals Online (AJOL)

    At any time we interprete paediatric chemical pathology test results we must take into consideration a number of factors, which are related with and restricted to paediatric patients. Such factors include the paediatric patient's age that may change from prematurity to above 18 years, and the paediatric patient's body weight ...

  6. VEGETABLE OILS AS SUBSTITUTION FOR DIESEL OIL Test results ...

    African Journals Online (AJOL)

    Test results obtained on a Diesel Engine with direct injection. W. Scheer, Professor ... High kinematic viscosities, high flash points and high ... nozzle and in the combustion chamber. This is ... speed, fuel consumption and exhaust tempera· tures. ... it enters the fuel system of the engine. An one ..... Internal publi- cation of ...

  7. SIMS prototype System 3 test results: engineering analysis

    Energy Technology Data Exchange (ETDEWEB)

    1978-08-01

    The results obtained during testing of a closed hydronic drain down solar system designed for space and hot water heating are presented. Data analysis is included which documents the system performance and verifies the suitability of SIMS Prototype System 3 for field installation.

  8. Multi-bundle shashlik calorimeter prototypes beam-test results

    International Nuclear Information System (INIS)

    Badier, J.; Bloch, P.; Bityukov, S.; Bordalo, P.; Busson, P.; Charlot, C.; Dobrzynski, L.; Golutvin, I.; Guschin, E.; Issakov, V.; Ivanchenko, I.; Klimenko, V.; Marin, V.; Moissenz, P.; Obraztsov, V.; Ostankov, A.; Popov, V.; Puljak, I.; Ramos, S.; Seez, C.; Sergueev, S.; Soushkov, V.; Tanaka, R.; Varela, J.; Virdee, T.S.; Zaitchenko, A.; Zamiatin, N.

    1995-01-01

    The first beam-test results for two- and three-bundle shashlik tower prototypes are described. We found that the spatial resolution, the uniformity of energy response, the calorimeter reliability and hermeticity and also two showers separation are improved in multi-bundle design approach. ((orig.))

  9. SIMS prototype system 3 test results: Engineering analysis

    Science.gov (United States)

    1978-01-01

    The results obtained during testing of a closed hydronic drain down solar system designed for space and hot water heating is presented. Data analysis is included which documents the system performance and verifies the suitability of SIMS Prototype System 3 for field installation.

  10. Results of the Intelligence Test for Visually Impaired Children (ITVIC).

    Science.gov (United States)

    Dekker, R.; And Others

    1991-01-01

    Statistical analyses of scores on subtests of the Intelligence Test for Visually Impaired Children were done for two groups of children, either with or without usable vision. Results suggest that the battery has differential factorial and predictive validity. (Author/DB)

  11. Test beam results obtained with the Q4 prototype

    International Nuclear Information System (INIS)

    Aguilar-Benitez, M.; Alberdi, J.; Cerrada, M.; Colino, N.; Daniel, M.; Fouz, M.C.; Marin, J.; Mocholi, J.; Oller, J. C.; Puerta, J.; Romero, L.; Salicio, J. M.; Willmott, C.

    2000-10-01

    A prototype of the CMS Barrel Muon Detector incorporating all the features of the final chambers was built at CIEMAT using the mass production assembly procedures and tools. The performance of this prototype was studied in a muon test beam at CERN and the results obtained are presented here. (Author)

  12. Fibrosis progression under maintenance interferon in hepatitis C is better detected by blood test than liver morphometry.

    Science.gov (United States)

    Calès, P; Zarski, J P; Chapplain, J Marc; Bertrais, S; Sturm, N; Michelet, C; Babany, G; Chaigneau, J; Eddine Charaf, M

    2012-02-01

    We evaluated whether quantitative measurements of liver fibrosis with recently developed diagnostics outperform histological staging in detecting natural or interferon-induced changes. We compared Metavir staging, morphometry (area and fractal dimension) and six blood tests in 157 patients with chronic hepatitis C from two trials testing maintenance interferon for 96 weeks. Paired liver biopsies and blood tests were available for 101 patients, and there was a significant improvement in Metavir activity and a significant increase in blood tests reflecting fibrosis quantity in patients treated with interferon when compared with controls - all per cent changes in histological fibrosis measures were significantly increased in F1 vs F2-4 stages only in the interferon group. For the whole population studied between weeks 0 and 96, there was significant progression only in the area of fibrosis (AOF) (P = 0.026), FibroMeter (P = 0.020) and CirrhoMeter (P = 0.003). With regards to dynamic reproducibility, agreement was good (r(ic) ≥ 0.72) only for Metavir fibrosis score, FibroMeter and CirrhoMeter. The per cent change in AOF was significantly higher than that of fractal dimension (P = 0.003) or Metavir fibrosis score (P = 0.015). CirrhoMeter was the only blood test with a change significantly higher than that of AOF (P = 0.039). AOF and two blood tests, reflecting fibrosis quantity, have high sensitivity and/or reproducibility permitting the detection of a small progression in liver fibrosis over two years. A blood test reflecting fibrosis quantity is more sensitive and reproducible than morphometry. The study also shows that maintenance interferon does not improve fibrosis, whatever its stage. © 2011 Blackwell Publishing Ltd.

  13. Routine Laboratory Blood Tests May Diagnose Significant Fibrosis in Liver Transplant Recipients with Chronic Hepatitis C: A 10 Year Experience.

    Science.gov (United States)

    Sheen, Victoria; Nguyen, Heajung; Jimenez, Melissa; Agopian, Vatche; Vangala, Sitaram; Elashoff, David; Saab, Sammy

    2016-03-28

    The aims of our study were to determine whether routine blood tests, the aspartate aminotransferase (AST) to Platelet Ratio Index (APRI) and Fibrosis 4 (Fib-4) scores, were associated with advanced fibrosis and to create a novel model in liver transplant recipients with chronic hepatitis C virus (HCV). We performed a cross sectional study of patients at The University of California at Los Angeles (UCLA) Medical Center who underwent liver transplantation for HCV. We used linear mixed effects models to analyze association between fibrosis severity and individual biochemical markers and mixed effects logistic regression to construct diagnostic models for advanced fibrosis (METAVIR F3-4). Cross-validation was used to estimate a receiving operator characteristic (ROC) curve for the prediction models and to estimate the area under the curve (AUC). The mean (± standard deviation [SD]) age of our cohort was 55 (±7.7) years, and almost three quarter were male. The mean (±SD) time from transplant to liver biopsy was 19.9 (±17.1) months. The mean (±SD) APRI and Fib-4 scores were 3 (±12) and 7 (±14), respectively. Increased fibrosis was associated with lower platelet count and alanine aminotransferase (ALT) values and higher total bilirubin and Fib-4 scores. We developed a model that takes into account age, gender, platelet count, ALT, and total bilirubin, and this model outperformed APRI and Fib-4 with an AUC of 0.68 (p fibrosis more reliably than APRI and Fib-4 scores. This noninvasive calculation may be used clinically to identify liver transplant recipients with HCV with significant liver damage.

  14. Test-retest reliability of diffusion tensor imaging of the liver at 3.0 T.

    Science.gov (United States)

    Girometti, Rossano; Maieron, Marta; Lissandrello, Giovanni; Bazzocchi, Massimo; Zuiani, Chiara

    2015-06-01

    This study was done to evaluate test-retest reliability of liver diffusion tensor imaging (LDTI). Ten healthy volunteers (median age 23 years) underwent two LDTI scans on a 3.0 T magnet during two imaging sessions separated by 2 weeks (session-1/-2, respectively). Fifteen gradient directions and b values of 0-1,000 s/mm(2) were used. Two radiologists in consensus assessed liver apparent diffusion coefficient (ADC) and fraction of anisotropy (FA) values on ADC and FA maps at four reference levels, namely: right upper level (RUL), right lower level (RLL), left upper level (LUL) and left lower level (LLL). We then assessed (a) whether ADC and FA values overlapped when measured on different levels within the same imaging session or between different imaging sessions; (b) the degree of variability on an intra-session and inter-session basis, respectively, using the coefficient of variation (CV). In sessions 1 and 2, the ADC/FA values were significantly larger in the left liver lobe (LUL/LLL) compared to right liver lobe (RUL/RLL) (p < 0.05/6). Intra-session CVs were 9.51 % (session 1) and 9.73 % (session 2) for ADC, and 12.93 % (session 1) and 11.82 % (session 2) for FA, respectively. When comparing RUL, RLL, LUL and LLL on an inter-session basis, CVs were 6.52, 8.20, 6.52 and 11.06 % for ADC, and 15.42, 15.80, 15.42 and 6.80 % for FA, respectively. LDTI provides consistent and repeatable measurements. However, since larger left lobe ADC/FA values can be attributed to artefacts, right lobe values should be considered the most reliable measurements of water diffusivity within the liver.

  15. Determination of the liver clearance of 131 J-bromosulfophthalein with partially shielded whole-body counter - method and clinical results

    International Nuclear Information System (INIS)

    Heyder, R.

    1980-01-01

    The aim of the study consisted first of all in working out a procedure to determine the liver clearance of 131 J-bromosulfophthalien according to the Oberhausen method and to inquire into the usability and sphere of validity of the Oberhausen approach. Subsequently a collective of patients was to be tested in order to find out whether it is possible with the aid of the clearance value to differentiate between persons with healthy livers and persons with liver disturbances respectively to assess the severity of a functional liver disorder. As the investigations were carried through as a part of the clinical routine, the information obtained by the clearance concept as compared to sequential scintiscanning and compartment analysis was to be investigated at the same time. (orig./MG) [de

  16. Large-Scale Spray Releases: Initial Aerosol Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Schonewill, Philip P.; Gauglitz, Phillip A.; Bontha, Jagannadha R.; Daniel, Richard C.; Kurath, Dean E.; Adkins, Harold E.; Billing, Justin M.; Burns, Carolyn A.; Davis, James M.; Enderlin, Carl W.; Fischer, Christopher M.; Jenks, Jeromy WJ; Lukins, Craig D.; MacFarlan, Paul J.; Shutthanandan, Janani I.; Smith, Dennese M.

    2012-12-01

    One of the events postulated in the hazard analysis at the Waste Treatment and Immobilization Plant (WTP) and other U.S. Department of Energy (DOE) nuclear facilities is a breach in process piping that produces aerosols with droplet sizes in the respirable range. The current approach for predicting the size and concentration of aerosols produced in a spray leak involves extrapolating from correlations reported in the literature. These correlations are based on results obtained from small engineered spray nozzles using pure liquids with Newtonian fluid behavior. The narrow ranges of physical properties on which the correlations are based do not cover the wide range of slurries and viscous materials that will be processed in the WTP and across processing facilities in the DOE complex. Two key technical areas were identified where testing results were needed to improve the technical basis by reducing the uncertainty due to extrapolating existing literature results. The first technical need was to quantify the role of slurry particles in small breaches where the slurry particles may plug and result in substantially reduced, or even negligible, respirable fraction formed by high-pressure sprays. The second technical need was to determine the aerosol droplet size distribution and volume from prototypic breaches and fluids, specifically including sprays from larger breaches with slurries where data from the literature are scarce. To address these technical areas, small- and large-scale test stands were constructed and operated with simulants to determine aerosol release fractions and generation rates from a range of breach sizes and geometries. The properties of the simulants represented the range of properties expected in the WTP process streams and included water, sodium salt solutions, slurries containing boehmite or gibbsite, and a hazardous chemical simulant. The effect of anti-foam agents was assessed with most of the simulants. Orifices included round holes and

  17. Space Launch System Base Heating Test: Experimental Operations & Results

    Science.gov (United States)

    Dufrene, Aaron; Mehta, Manish; MacLean, Matthew; Seaford, Mark; Holden, Michael

    2016-01-01

    NASA's Space Launch System (SLS) uses four clustered liquid rocket engines along with two solid rocket boosters. The interaction between all six rocket exhaust plumes will produce a complex and severe thermal environment in the base of the vehicle. This work focuses on a recent 2% scale, hot-fire SLS base heating test. These base heating tests are short-duration tests executed with chamber pressures near the full-scale values with gaseous hydrogen/oxygen engines and RSRMV analogous solid propellant motors. The LENS II shock tunnel/Ludwieg tube tunnel was used at or near flight duplicated conditions up to Mach 5. Model development was based on the Space Shuttle base heating tests with several improvements including doubling of the maximum chamber pressures and duplication of freestream conditions. Test methodology and conditions are presented, and base heating results from 76 runs are reported in non-dimensional form. Regions of high heating are identified and comparisons of various configuration and conditions are highlighted. Base pressure and radiometer results are also reported.

  18. Graphite electrode arc melter demonstration Phase 2 test results

    International Nuclear Information System (INIS)

    Soelberg, N.R.; Chambers, A.G.; Anderson, G.L.; O'Connor, W.K.; Oden, L.L.; Turner, P.C.

    1996-06-01

    Several U.S. Department of Energy organizations and the U.S. Bureau of Mines have been collaboratively conducting mixed waste treatment process demonstration testing on the near full-scale graphite electrode submerged arc melter system at the Bureau's Albany (Oregon) Research Center. An initial test series successfully demonstrated arc melter capability for treating surrogate incinerator ash of buried mixed wastes with soil. The conceptual treatment process for that test series assumed that buried waste would be retrieved and incinerated, and that the incinerator ash would be vitrified in an arc melter. This report presents results from a recently completed second series of tests, undertaken to determine the ability of the arc melter system to stably process a wide range of open-quotes as-receivedclose quotes heterogeneous solid mixed wastes containing high levels of organics, representative of the wastes buried and stored at the Idaho National Engineering Laboratory (INEL). The Phase 2 demonstration test results indicate that an arc melter system is capable of directly processing these wastes and could enable elimination of an up-front incineration step in the conceptual treatment process

  19. Graphite electrode arc melter demonstration Phase 2 test results

    Energy Technology Data Exchange (ETDEWEB)

    Soelberg, N.R.; Chambers, A.G.; Anderson, G.L.; O`Connor, W.K.; Oden, L.L.; Turner, P.C.

    1996-06-01

    Several U.S. Department of Energy organizations and the U.S. Bureau of Mines have been collaboratively conducting mixed waste treatment process demonstration testing on the near full-scale graphite electrode submerged arc melter system at the Bureau`s Albany (Oregon) Research Center. An initial test series successfully demonstrated arc melter capability for treating surrogate incinerator ash of buried mixed wastes with soil. The conceptual treatment process for that test series assumed that buried waste would be retrieved and incinerated, and that the incinerator ash would be vitrified in an arc melter. This report presents results from a recently completed second series of tests, undertaken to determine the ability of the arc melter system to stably process a wide range of {open_quotes}as-received{close_quotes} heterogeneous solid mixed wastes containing high levels of organics, representative of the wastes buried and stored at the Idaho National Engineering Laboratory (INEL). The Phase 2 demonstration test results indicate that an arc melter system is capable of directly processing these wastes and could enable elimination of an up-front incineration step in the conceptual treatment process.

  20. Comparison of transient PCRV model test results with analysis

    International Nuclear Information System (INIS)

    Marchertas, A.H.; Belytschko, T.B.

    1979-01-01

    Comparisons are made of transient data derived from simple models of a reactor containment vessel with analytical solutions. This effort is a part of the ongoing process of development and testing of the DYNAPCON computer code. The test results used in these comparisons were obtained from scaled models of the British sodium cooled fast breeder program. The test structure is a scaled model of a cylindrically shaped reactor containment vessel made of concrete. This concrete vessel is prestressed axially by holddown bolts spanning the top and bottom slabs along the cylindrical walls, and is also prestressed circumferentially by a number of cables wrapped around the vessel. For test purposes this containment vessel is partially filled with water, which comes in direct contact with the vessel walls. The explosive charge is immersed in the pool of water and is centrally suspended from the top of the vessel. The tests are very similar to the series of tests made for the COVA experimental program, but the vessel here is the prestressed concrete container. (orig.)

  1. 688,112 statistical results: Content mining psychology articles for statistical test results

    OpenAIRE

    Hartgerink, C.H.J.

    2016-01-01

    In this data deposit, I describe a dataset that is the result of content mining 167,318 published articles for statistical test results reported according to the standards prescribed by the American Psychological Association (APA). Articles published by the APA, Springer, Sage, and Taylor & Francis were included (mining from Wiley and Elsevier was actively blocked). As a result of this content mining, 688,112 results from 50,845 articles were extracted. In order to provide a comprehensive set...

  2. Results of MACE tests M0 and M1

    International Nuclear Information System (INIS)

    Spencer, B.W.; Farmer, M.T.; Armstrong, D.R.; Kilsdonk, D.J.; Aeschlimann, R.W.; Fischer, M.

    1992-01-01

    This document discusses the Melt Attack and Coolability Experiment (MACE) Program underway at Argonne National Laboratory under ACE/EPRI sponsorship. The program addresses the efficacy of water to terminate an accident situation if melt progression were to result in a molten core/concrete interaction (MCCI) in the reactor containment. Large-scale experiments are being conducted in parallel with related modeling efforts, involving the addition of water to an MCI already underway. The experiments utilize UO 2 /ZrO 2 /Zr corium mixtures, direct electrical heating for simulation of decay heating, and various types of concrete basemats. Currently the tests involve 430 kg corium mass, 25 cm depth, in a 50 cm square test section. Test MO was a successful scoping test, but the first full size test, Ml, failed to achieve melt-water contact owing to existence of a preexisting bridge crust of corium charge. A heat flux of 3.5 MW/m 2 was measured in MO which removed energy from the corium pool equivalent to its entire heat of solidification prior to abatement by formation of an interfacial crust. The crust subsequently limited heat extraction to 600 kW/m 2 and less. Both tests MO and Ml revealed physical evidence of large pool swelling events which resulted in extrusion (and ejection) of melt into water above the crust, significantly increasing the overall quench and reducing the remaining melt in contact with the concrete. Furthermore, test Ml provided evidence of occasional ''burst mode'' ablation events and one additional important benefit of overlying water -- aerosol capture

  3. Paternity tests in Mexico: Results obtained in 3005 cases.

    Science.gov (United States)

    García-Aceves, M E; Romero Rentería, O; Díaz-Navarro, X X; Rangel-Villalobos, H

    2018-04-01

    National and international reports regarding the paternity testing activity scarcely include information from Mexico and other Latin American countries. Therefore, we report different results from the analysis of 3005 paternity cases analyzed during a period of five years in a Mexican paternity testing laboratory. Motherless tests were the most frequent (77.27%), followed by trio cases (20.70%); the remaining 2.04% included different cases of kinship reconstruction. The paternity exclusion rate was 29.58%, higher but into the range reported by the American Association of Blood Banks (average 24.12%). We detected 65 mutations, most of them involving one-step (93.8% and the remaining were two-step mutations (6.2%) thus, we were able to estimate the paternal mutation rate for 17 different STR loci: 0.0018 (95% CI 0.0005-0.0047). Five triallelic patterns and 12 suspected null alleles were detected during this period; however, re-amplification of these samples with a different Human Identification (HID) kit confirmed the homozygous genotypes, which suggests that most of these exclusions actually are one-step mutations. HID kits with ≥20 STRs detected more exclusions, diminishing the rate of inconclusive results with isolated exclusions (Powerplex 21 kit (20 STRs) and Powerplex Fusion kit (22 STRs) offered similar PI (p = 0.379) and average number of exclusions (PE) (p = 0.339) when a daughter was involved in motherless tests. In brief, besides to report forensic parameters from paternity tests in Mexico, results describe improvements to solve motherless paternity tests using HID kits with ≥20 STRs instead of one including 15 STRs. Copyright © 2018 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  4. Potential for false positive HIV test results with the serial rapid HIV testing algorithm.

    Science.gov (United States)

    Baveewo, Steven; Kamya, Moses R; Mayanja-Kizza, Harriet; Fatch, Robin; Bangsberg, David R; Coates, Thomas; Hahn, Judith A; Wanyenze, Rhoda K

    2012-03-19

    Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals.

  5. Long Term Corrosion/Degradation Test Six Year Results

    Energy Technology Data Exchange (ETDEWEB)

    M. K. Adler Flitton; C. W. Bishop; M. E. Delwiche; T. S. Yoder

    2004-09-01

    The Subsurface Disposal Area (SDA) of the Radioactive Waste Management Complex (RWMC) located at the Idaho National Engineering and Environmental Laboratory (INEEL) contains neutron-activated metals from non-fuel, nuclear reactor core components. The Long-Term Corrosion/Degradation (LTCD) Test is designed to obtain site-specific corrosion rates to support efforts to more accurately estimate the transfer of activated elements to the environment. The test is using two proven, industry-standard methods—direct corrosion testing using metal coupons, and monitored corrosion testing using electrical/resistance probes—to determine corrosion rates for various metal alloys generally representing the metals of interest buried at the SDA, including Type 304L stainless steel, Type 316L stainless steel, Inconel 718, Beryllium S200F, Aluminum 6061, Zircaloy-4, low-carbon steel, and Ferralium 255. In the direct testing, metal coupons are retrieved for corrosion evaluation after having been buried in SDA backfill soil and exposed to natural SDA environmental conditions for times ranging from one year to as many as 32 years, depending on research needs and funding availability. In the monitored testing, electrical/resistance probes buried in SDA backfill soil will provide corrosion data for the duration of the test or until the probes fail. This report provides an update describing the current status of the test and documents results to date. Data from the one-year and three-year results are also included, for comparison and evaluation of trends. In the six-year results, most metals being tested showed extremely low measurable rates of general corrosion. For Type 304L stainless steel, Type 316L stainless steel, Inconel 718, and Ferralium 255, corrosion rates fell in the range of “no reportable” to 0.0002 mils per year (MPY). Corrosion rates for Zircaloy-4 ranged from no measurable corrosion to 0.0001 MPY. These rates are two orders of magnitude lower than those specified in

  6. Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain

    International Nuclear Information System (INIS)

    Duran, Joan; Navarro-Sabate, Aurea; Pujol, Anna; Perales, Jose C.; Manzano, Anna; Obach, Merce; Gomez, Marta; Bartrons, Ramon

    2008-01-01

    Fructose 2,6-bisphosphate (Fru-2,6-P 2 ) is an important metabolite that controls glycolytic and gluconeogenic pathways in several cell types. Its synthesis and degradation are catalyzed by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK-2). Four genes, designated Pfkfb1-4, codify the different PFK-2 isozymes. The Pfkfb3 gene product, ubiquitous PFK-2 (uPFK-2), has the highest kinase/bisphosphatase activity ratio and is associated with proliferation and tumor metabolism. A transgenic mouse model that overexpresses uPFK-2 under the control of the phosphoenolpyruvate carboxykinase promoter was designed to promote sustained and elevated Fru-2,6-P 2 levels in the liver. Our results demonstrate that in diet-induced obesity, high Fru-2,6-P 2 levels in transgenic livers caused changes in hepatic gene expression profiles for key gluconeogenic and lipogenic enzymes, as well as an accumulation of lipids in periportal cells, and weight gain

  7. The TRANSRAPID propulsion system - development and test results

    Energy Technology Data Exchange (ETDEWEB)

    Henning, U [Siemens AG, Erlangen (Germany); Kamp, P G [Siemens AG, Erlangen (Germany); Hochleitner, J [Siemens AG, Erlangen (Germany)

    1996-12-31

    The structure of the propulsion system for the Transrapid comprises a number of components which are located along the guideway. These drive components are temporarily switched together to form the drive control zones necessary to permit maglev operation over the guideway. The paper describes the development of the stationary propulsion converter with GTO thyristors. The drive components are tested under realistic operating conditions. The test results confirm the performance capability as well as verify the suitability of the concept for use in revenue service. (HW)

  8. Thermosyphon Flooding in Reduced Gravity Environments Test Results

    Science.gov (United States)

    Gibson, Marc A.; Jaworske, Donald A.; Sanzi, Jim; Ljubanovic, Damir

    2013-01-01

    The condenser flooding phenomenon associated with gravity aided two-phase thermosyphons was studied using parabolic flights to obtain the desired reduced gravity environment (RGE). The experiment was designed and built to test a total of twelve titanium water thermosyphons in multiple gravity environments with the goal of developing a model that would accurately explain the correlation between gravitational forces and the maximum axial heat transfer limit associated with condenser flooding. Results from laboratory testing and parabolic flights are included in this report as part I of a two part series. The data analysis and correlations are included in a follow on paper.

  9. PISA TESTS IN LATIN AMERICA: RESULTS IN CONTEXT

    Directory of Open Access Journals (Sweden)

    Guillermina Tiramonti

    2014-05-01

    Full Text Available The educational reforms implemented in Latin America in the ‘90s introduced changes in the modes of regulation of educational systems based on the adoption of mechanisms for assessing student achievement. Since 2000, eight Latin-American countries (Argentina, Chile, Uruguay, Colombia, Brazil, Costa Rica, Mexico and Peru are involved in the PISA tests. The article presents a brief review of the social and educational situation of the Region, relevant for the interpretation and comparative analysis of the results of these tests that is presented below.

  10. Test Results of the ALICE-HMPID Detector Commissioning

    CERN Document Server

    Volpe, G

    2008-01-01

    The ALICE High Momentum Particle Identification Detector (HMPID) consists of seven identical proximity focusing RICH counters. It covers in total 11 m2, exploiting large area CsI photocathodes for Cherenkov light imaging. The detector is installed in the ALICE solenoid, ready for the data acquisition. By means of the Detector Control System, the Front-end (FEE) and the Readout (R/O) electronics, the MWPC high voltages, the cooling and the gas system have been tested. The HMPID module gas pressure, temperature, current and voltage trends have been monitored and archived in the ORACLE database. In this paper a comprehensive review on the test results is presented.

  11. Patch Test Results of 775 Patients with Allergic Contact Dermatitis

    Directory of Open Access Journals (Sweden)

    Simin Ada

    2010-12-01

    Full Text Available Background and Design: The allergens responsible for allergic contact dermatitis vary among countries and even between different geographical regions within the same country over time. It is of great importance to perform the patch test at certain intervals, to evaluate the results in different centers and to compare them afterwards. Our aim was to evaluate the patch test results in our patients with allergic contact dermatitis.Material and Method: The records of the patients with allergic contact dermatitis, who had been patch tested between May 1997 and March 2009, were analyzed retrospectively. The demographic features such as age and sex, localization of the contact dermatitis, and the patch test results were recorded. Results: Of the 775 patients, 581 (75.2% were females and 194 (25% males. Of all patients, 735 were patch tested with the European Standard Series, 318 - with both the European Standard Series and cosmetic series, and 40-with cosmetic series alone. Of the patients tested with the European Standard Series, 255 (34.7% had at least one positive reaction. The most frequent allergen in the European Standard Series was nickel sulfate (17.3%, followed by cobalt chloride (7.2%, potassium dichromate (3%, fragrance mix (2.9%, and p-phenylenediamine base (2.6%. Of the 358 patients tested with cosmetic series, 82 (22.9% had at least one positive reaction. The 5 most frequently observed cosmetic series allergens were octyl gallate (3.9%, thimerosal (2.2%, sorbitan sesquioleate (2%, Euxyl K 400 (2% and methyldibromo glutaronitrile (1.4%. Conclusion: Our study shows the contact allergen profile of our center over 12 years. The most common allergens and their frequency differ between centers in various cities in Turkey. Those geographical differences should be re-evaluated by further studies performed in the certain time period. The high frequency of reactions to octyl gallate is an important finding in patients suspected of cosmetic allergy

  12. Liver Function Testing with Nuclear Medicine Techniques Is Coming of Age

    NARCIS (Netherlands)

    Bennink, Roelof J.; Tulchinsky, Mark; de Graaf, Wilmar; Kadry, Zakiyah; van Gulik, Thomas M.

    2012-01-01

    Liver function is a broad term, as the organ participates in a multitude of different physiological and biochemical processes, including metabolic, synthetic, and detoxifying functions. However, it is the function of the hepatocyte that is central to sustaining normal life and dealing with disease

  13. Frequency and Prognostic Significance of Abnormal Liver Function Tests in Patients With Cardiogenic Shock

    DEFF Research Database (Denmark)

    Jäntti, Toni; Tarvasmäki, Tuukka; Harjola, Veli Pekka

    2017-01-01

    Cardiogenic shock (CS) is a cardiac emergency often leading to multiple organ failure and death. Assessing organ dysfunction and appropriate risk stratification are central for the optimal management of these patients. The purpose of this study was to assess the prevalence of abnormal liver funct...

  14. 688,112 statistical results : Content mining psychology articles for statistical test results

    NARCIS (Netherlands)

    Hartgerink, C.H.J.

    2016-01-01

    In this data deposit, I describe a dataset that is the result of content mining 167,318 published articles for statistical test results reported according to the standards prescribed by the American Psychological Association (APA). Articles published by the APA, Springer, Sage, and Taylor & Francis

  15. Phase III Simplified Integrated Test (SIT) results - Space Station ECLSS testing

    Science.gov (United States)

    Roberts, Barry C.; Carrasquillo, Robyn L.; Dubiel, Melissa Y.; Ogle, Kathryn Y.; Perry, Jay L.; Whitley, Ken M.

    1990-01-01

    During 1989, phase III testing of Space Station Freedom Environmental Control and Life Support Systems (ECLSS) began at Marshall Space Flight Center (MSFC) with the Simplified Integrated Test. This test, conducted at the MSFC Core Module Integration Facility (CMIF), was the first time the four baseline air revitalization subsystems were integrated together. This paper details the results and lessons learned from the phase III SIT. Future plans for testing at the MSFC CMIF are also discussed.

  16. Results of the quality assurance testing program for radiopharmaceuticals 1995

    International Nuclear Information System (INIS)

    Baldas, J.; Binnyman, J.; Ivanov, Z.; Lauder, R.

    1996-07-01

    The results of the quality assurance testing conducted by the Australian Radiation Laboratory is summarised. Overall 111 batches of 27 different types of radiopharmaceuticals were tested on samples obtained through normal commercial channels. Failure to meet full specifications was observed in 10 of the 111 batches. All technetium-99m cold kits were reconstituted according to the directions in the package insert using sodium pertechnetate ( 99m Tc) injection. Radionuclidic purity has been determined at the calibration time, except for Thallous [ 201 Tl] Chloride injection where the highest impurity level up to product expiry is quoted. Non-compliance of the vial label was observed in one of the ten batches failing specification and was the sole cause of product failure for this batch. Vial label non-compliance consisted of, absence of volume in the vial. Six batches failed the biodistribution test but in no case did this involve failure of the distribution for the target organs. tabs

  17. Initial CGE Model Results Summary Exogenous and Endogenous Variables Tests

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Brian Keith [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Boero, Riccardo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rivera, Michael Kelly [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-07

    The following discussion presents initial results of tests of the most recent version of the National Infrastructure Simulation and Analysis Center Dynamic Computable General Equilibrium (CGE) model developed by Los Alamos National Laboratory (LANL). The intent of this is to test and assess the model’s behavioral properties. The test evaluated whether the predicted impacts are reasonable from a qualitative perspective. This issue is whether the predicted change, be it an increase or decrease in other model variables, is consistent with prior economic intuition and expectations about the predicted change. One of the purposes of this effort is to determine whether model changes are needed in order to improve its behavior qualitatively and quantitatively.

  18. Results of the quality assurance testing program for radiopharmaceuticals 1995

    Energy Technology Data Exchange (ETDEWEB)

    Baldas, J.; Binnyman, J.; Ivanov, Z.; Lauder, R.

    1996-07-01

    The results of the quality assurance testing conducted by the Australian Radiation Laboratory is summarised. Overall 111 batches of 27 different types of radiopharmaceuticals were tested on samples obtained through normal commercial channels. Failure to meet full specifications was observed in 10 of the 111 batches. All technetium-99m cold kits were reconstituted according to the directions in the package insert using sodium pertechnetate ( {sup 99m}Tc) injection. Radionuclidic purity has been determined at the calibration time, except for Thallous [{sup 201}Tl] Chloride injection where the highest impurity level up to product expiry is quoted. Non-compliance of the vial label was observed in one of the ten batches failing specification and was the sole cause of product failure for this batch. Vial label non-compliance consisted of, absence of volume in the vial. Six batches failed the biodistribution test but in no case did this involve failure of the distribution for the target organs. tabs.

  19. TEST RESULTS FOR LHC INSERTION REGION DEPOLE MAGNETS

    International Nuclear Information System (INIS)

    MURATORE, J.; JAIN, A.; ANERELLA, M.; COSSOLINO, J.

    2005-01-01

    The Superconducting Magnet Division at Brookhaven National Laboratory (BNL) has made 20 insertion region dipoles for the Large Hadron Collider (LHC) at CERN. These 9.45 m-long, 8 cm aperture magnets have the same coil design as the arc dipoles now operating in the Relativistic Heavy Ion Collider (RHIC) at BNL and are of single aperture, twin aperture, and double cold mass configurations. They are required to produce fields up to 4.14 T for operation at 7.56 TeV. Eighteen of these magnets have been tested at 4.5 K using either forced flow supercritical helium or liquid helium. The testing was especially important for the twin aperture models, whose construction was very different from the RHIC dipoles, except for the coil design. This paper reports on the results of these tests, including spontaneous quench performance, verification of quench protection heater operation, and magnetic field quality

  20. Using Large Scale Test Results for Pedagogical Purposes

    DEFF Research Database (Denmark)

    Dolin, Jens

    2012-01-01

    The use and influence of large scale tests (LST), both national and international, has increased dramatically within the last decade. This process has revealed a tension between the legitimate need for information about the performance of the educational system and teachers to inform policy......, and the teachers’ and students’ use of this information for pedagogical purposes in the classroom. We know well how the policy makers interpret and use the outcomes of such tests, but we know less about how teachers make use of LSTs to inform their pedagogical practice. An important question is whether...... there is a contradiction between the political system’s use of LST and teachers’ (possible) pedagogical use of LST. And if yes: What is a contradiction based on? This presentation will give some results from a systematic review on how tests have influenced the pedagogical practice. The research revealed many of the fatal...

  1. SP-100 Fuel Pin Performance: Results from Irradiation Testing

    Science.gov (United States)

    Makenas, Bruce J.; Paxton, Dean M.; Vaidyanathan, Swaminathan; Marietta, Martin; Hoth, Carl W.

    1994-07-01

    A total of 86 experimental fuel pins with various fuel, liner, and cladding candidate materials have been irradiated in the Experimental Breeder Reactor-II (EBR-II) and the Fast Flux Test Facility (FFTF) reactor as part of the SP-100 fuel pin irradiation testing program. Postirradiation examination results from these fuel pins are key in establishing performance correlations and demonstrating the lifetime and safety of the reactor fuel system. This paper provides a brief description of the in-reactor fuel pin tests and presents the most recent irradiation data on the performance of wrought rhenium (Re) liner material and high density UN fuel at goal burnup of 6 atom percent (at. %). It also provides an overview of the significant variety of other fuel/liner/cladding combinations which were irradiated as part of this program and which may be of interest to more advanced efforts.

  2. Containment liner plate anchors and steel embedments test results

    International Nuclear Information System (INIS)

    Chang-Lo, P.L.; Johnson, T.E.; Pfeifer, B.W.

    1977-01-01

    This paper summarizes test data on shear load and deformation capabilities for liner plate line anchors and structural steel embedments in reinforced and prestressed concrete nuclear containments. Reinforced and prestressed nuclear containments designed and constructed in the United States are lined with a minimum of 0.64 cm steel plate. The liner plates are anchored by the use of either studs or structural members (line anchors) which usually run in the vertical direction. This paper will only address line anchors. Static load versus displacement test data is necessary to assure that the design is adequate for the maximum loads. The test program for the liner anchors had the following major objectives: determine load versus displacement data for a variety of anchors considering structural tees and small beams with different weld configurations, from the preceding tests, determine which anchors would lead to an economical and extremely safe design and test these anchors for cyclic loads resulting from thermal fluctuations. Various concrete embeds in the containment and other structures are subjected to loads such as pipe rupture which results in shear. Since many of the loads are transient by nature, it is necessary to know the load-displacement relationship so that the energy absorption can be determined. The test program for the embeds had the following objectives: determine load-displacement relationship for various size anchors from 6.5 cm 2 to 26 cm 2 with maximum capacities of approximately 650 kN; determine the effect of various anchor width-to-thickness ratios for the same shear area

  3. Results of gap conductance tests in the power burst facility

    International Nuclear Information System (INIS)

    Garner, R.W.; Sparks, D.T.

    1977-01-01

    Light water reactor (LWR) fuel rod behavior studies are being conducted by the Thermal Fuels Behavior Program of EG and G Idaho, Inc. These studies are being performed under contract to the Energy Research and Development Adminstration at the Idaho National Engineering Laboratory (INEL), as part of the Nuclear Regulatory Commission's Water Reactor Safety Research Fuel Behavior Program. Experimental data for verification of analytical models developed to predict light water nuclear fuel rod behavior under normal and postulated accident conditions are being obtained from a variety of in-reactor and out-of-reactor experiments. This paper summarizes the results of tests performed in the Power Burst Facility (PBF) to obtain data from which the thermal response, gap conductance, and stored energy of LWR fuel rods can be determined. Primary objectives of the PBF gap conductance test program are (a) to obtain data on a variety of pressurized water reactor (PWR) and boiling water reactor (BWR) fuel rod designs, under a wide range of operating conditions, from which gap conductance values can be determined and (b) to evaluate experimentally the power oscillation method for measuring the gap conductance and thermal response of a fresh or burned LWR fuel rod. Tests have been performed with both irradiated and unirradiated PWR-type fuel and with fresh BWR-type fuel rods. Some PWR rod test results are described, and the thermal response data from BWR rod tests are discussed in greater detail. Comparisons are made of gap conductance values determined by the tests with analytically calculated values using the Fuel Rod Analysis Program-Transient (FRAP-T) computer code. These comparisons provide insight into both the experimental measurements methods and the validity of the gap conductance models

  4. Large-Scale Spray Releases: Additional Aerosol Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, Richard C.; Gauglitz, Phillip A.; Burns, Carolyn A.; Fountain, Matthew S.; Shimskey, Rick W.; Billing, Justin M.; Bontha, Jagannadha R.; Kurath, Dean E.; Jenks, Jeromy WJ; MacFarlan, Paul J.; Mahoney, Lenna A.

    2013-08-01

    One of the events postulated in the hazard analysis for the Waste Treatment and Immobilization Plant (WTP) and other U.S. Department of Energy (DOE) nuclear facilities is a breach in process piping that produces aerosols with droplet sizes in the respirable range. The current approach for predicting the size and concentration of aerosols produced in a spray leak event involves extrapolating from correlations reported in the literature. These correlations are based on results obtained from small engineered spray nozzles using pure liquids that behave as a Newtonian fluid. The narrow ranges of physical properties on which the correlations are based do not cover the wide range of slurries and viscous materials that will be processed in the WTP and in processing facilities across the DOE complex. To expand the data set upon which the WTP accident and safety analyses were based, an aerosol spray leak testing program was conducted by Pacific Northwest National Laboratory (PNNL). PNNL’s test program addressed two key technical areas to improve the WTP methodology (Larson and Allen 2010). The first technical area was to quantify the role of slurry particles in small breaches where slurry particles may plug the hole and prevent high-pressure sprays. The results from an effort to address this first technical area can be found in Mahoney et al. (2012a). The second technical area was to determine aerosol droplet size distribution and total droplet volume from prototypic breaches and fluids, including sprays from larger breaches and sprays of slurries for which literature data are mostly absent. To address the second technical area, the testing program collected aerosol generation data at two scales, commonly referred to as small-scale and large-scale testing. The small-scale testing and resultant data are described in Mahoney et al. (2012b), and the large-scale testing and resultant data are presented in Schonewill et al. (2012). In tests at both scales, simulants were used

  5. Spent fuel drying system test results (second dry-run)

    International Nuclear Information System (INIS)

    Klinger, G.S.; Oliver, B.M.; Abrefah, J.; Marschman, S.C.; MacFarlan, P.J.; Ritter, G.A.

    1998-07-01

    The water-filled K-Basins in the Hanford 100 Area have been used to store N-Reactor spent nuclear fuel (SNF) since the 1970s. Because some leaks have been detected in the basins and some of the fuel is breached due to handling damage and corrosion, efforts are underway to remove the fuel elements from wet storage. An Integrated Process Strategy (IPS) has been developed to package, dry, transport, and store these metallic uranium fuel elements in an interim storage facility on the Hanford Site (WHC 1995). Information required to support the development of the drying processes, and the required safety analyses, is being obtained from characterization tests conducted on fuel elements removed from the K-Basins. A series of whole element drying tests (reported in separate documents, see Section 7.0) have been conducted by Pacific Northwest National Laboratory (PNNL) on several intact and damaged fuel elements recovered from both the K-East and K-West Basins. This report documents the results of the second dry-run test, which was conducted without a fuel element. With the concurrence of project management, the test protocol for this run, and subsequent drying test runs, was modified. These modifications were made to allow for improved data correlation with drying procedures proposed under the IPS. Details of these modifications are discussed in Section 3.0

  6. Experimental Results of Integrated Refrigeration and Storage System Testing

    Science.gov (United States)

    Notardonato, W. U.; Johnson, W. L.; Jumper, K.

    2009-01-01

    Launch operations engineers at the Kennedy Space Center have identified an Integrated Refrigeration and Storage system as a promising technology to reduce launch costs and enable advanced cryogenic operations. This system uses a close cycle Brayton refrigerator to remove energy from the stored cryogenic propellant. This allows for the potential of a zero loss storage and transfer system, as well and control of the state of the propellant through densification or re-liquefaction. However, the behavior of the fluid in this type of system is different than typical cryogenic behavior, and there will be a learning curve associated with its use. A 400 liter research cryostat has been designed, fabricated and delivered to KSC to test the thermo fluid behavior of liquid oxygen as energy is removed from the cryogen by a simulated DC cycle cryocooler. Results of the initial testing phase focusing on heat exchanger characterization and zero loss storage operations using liquid oxygen are presented in this paper. Future plans for testing of oxygen densification tests and oxygen liquefaction tests will also be discussed. KEYWORDS: Liquid Oxygen, Refrigeration, Storage

  7. Results of patch testing with lavender oil in Japan.

    Science.gov (United States)

    Sugiura, M; Hayakawa, R; Kato, Y; Sugiura, K; Hashimoto, R

    2000-09-01

    We report the annual results of patch testing with lavender oil for a 9-year period from 1990 to 1998 in Japan. Using Finn Chambers and Scanpor tape, we performed 2-day closed patch testing with lavender oil 20% pet. on the upper back of each patient suspected of having cosmetic contact dermatitis. We compared the frequency of positive patch tests to lavender oil each year with those to other fragrances. We diagnosed contact allergy when patch test reactions were + or Japan, there has been a trend for aromatherapy using lavender oil. With this trend, placing dried lavender flowers in pillows, drawers, cabinets, or rooms has become a new fashion. We asked patients who showed a positive reaction to lavender oil about their use of dried lavender flowers. We confirmed the use of dried lavender flowers in 5 cases out of 11 positive cases in 1997 and 8 out of 15 positive cases in 1998. We concluded that the increase in patch test positivity rates to lavender oil in 1997 and 1998 was due to the above fashion, rather than due to fragrances in cosmetic products.

  8. Overview of results from 2D airfoil testing at Risoe

    Energy Technology Data Exchange (ETDEWEB)

    Fuglsang, P. [Risoe National Lab., Wind Energy and Atmospheric Physics Dept., Roskilde (Denmark)

    1997-12-31

    This paper gives an overview of the results from two dimensional airfoil testing at Risoe. A two dimensional testing method was recently developed where a test rig is inserted into an open jet flow in a wind tunnel of the close return loop type with an open test section. Pressure measurements provide the lift and drag forces. Both stationary flow and dynamic inflow from pitch motion are possible. The wind tunnel static pressure and total dynamic pressures were calibrated and wind tunnel boundary corrections were found. So far, the testing method was verified by comparison of NACA 63-215 airfoil measurements to numerical predictions and to measurements. Furthermore, the Risoe-1, FFA-W3-241, FFA-W3-301 and NACA 63-430 airfoils were measured. Different types of leading edge roughness and vortex generators were investigated. For all airfoils, good agreements with predictions were obtained on both pressure distribution and on lift coefficient. The drag coefficients were slightly higher than predicted. (eg) 10 refs.

  9. VLT deformable secondary mirror: integration and electromechanical tests results

    Science.gov (United States)

    Biasi, R.; Andrighettoni, M.; Angerer, G.; Mair, C.; Pescoller, D.; Lazzarini, P.; Anaclerio, E.; Mantegazza, M.; Gallieni, D.; Vernet, E.; Arsenault, R.; Madec, P.-Y.; Duhoux, P.; Riccardi, A.; Xompero, M.; Briguglio, R.; Manetti, M.; Morandini, M.

    2012-07-01

    The VLT Deformable secondary is planned to be installed on the VLT UT#4 as part of the telescope conversion into the Adaptive Optics test Facility (AOF). The adaptive unit is based on the well proven contactless, voice coil motor technology that has been already successfully implemented in the MMT, LBT and Magellan adaptive secondaries, and is considered a promising technical choice for the forthcoming ELT-generation adaptive correctors, like the E-ELT M4 and the GMT ASM. The VLT adaptive unit has been recently assembled after the completion of the manufacturing and modular test phases. In this paper, we present the most relevant aspects of the system integration and report the preliminary results of the electromechanical tests performed on the unit. This test campaign is a typical major step foreseen in all similar systems built so far: thanks to the metrology embedded in the system, that allows generating time-dependent stimuli and recording in real time the position of the controlled mirror on all actuators, typical dynamic response quality parameters like modal settling time, overshoot and following error can be acquired without employing optical measurements. In this way the system dynamic and some aspect of its thermal and long term stability can be fully characterized before starting the optical tests and calibrations.

  10. Test Results for the Automated Rendezvous and Capture System

    Science.gov (United States)

    Cruzen, Craig; Dabney, Richard; Lomas, James

    1999-01-01

    The Automated Rendezvous and Capture (AR&C) system was designed and tested at NASA's Marshall Space Flight Center (MSFC) to demonstrate technologies and mission strategies for automated rendezvous and docking of spacecraft in Earth orbit, The system incorporates some of the latest innovations in Global Positioning, System space navigation, laser sensor technologies and automated mission sequencing algorithms. The system's initial design and integration was completed in 1998 and has undergone testing at MSFC. This paper describes the major components of the AR&C system and presents results from the official system tests performed in MSFC's Flight Robotics Laboratory with digital simulations and hardware in the loop tests. The results show that the AR&C system can safely and reliably perform automated rendezvous and docking missions in the absence of system failures with 100 percent success. When system failures are included, the system uses its automated collision avoidance maneuver logic to recover in a safe manner. The primary objective of the AR&C project is to prove that by designing a safe and robust automated system, mission operations cost can be reduced by decreasing the personnel required for mission design, preflight planning and training required for crewed rendezvous and docking missions.

  11. Honeywell Cascade Distiller System Performance Testing Interim Results

    Science.gov (United States)

    Callahan, Michael R.; Sargusingh, Miriam

    2014-01-01

    The ability to recover and purify water through physiochemical processes is crucial for realizing long-term human space missions, including both planetary habitation and space travel. Because of their robust nature, distillation systems have been actively pursued as one of the technologies for water recovery. The Cascade Distillation System (CDS) is a vacuum rotary distillation system with potential for greater reliability and lower energy costs than existing distillation systems. The CDS was previously under development through Honeywell and NASA. In 2009, an assessment was performed to collect data to support down-selection and development of a primary distillation technology for application in a lunar outpost water recovery system. Based on the results of this testing, an expert panel concluded that the CDS showed adequate development maturity, TRL-4, together with the best product water quality and competitive weight and power estimates to warrant further development. The Advanced Exploration Systems (AES) Water Recovery Project (WRP) worked to address weaknesses identified by The Panel; namely bearing design and heat pump power efficiency. Testing at the NASA-JSC Advanced Exploration System Water Laboratory (AES Water Lab) using a prototype Cascade Distillation Subsystem (CDS) wastewater processor (Honeywell International, Torrance, Calif.) with test support equipment and control system developed by Johnson Space Center was performed to evaluate performance of the system with the upgrades. The CDS will also have been challenged with ISS analog waste streams and a subset of those being considered for Exploration architectures. This paper details interim results of the AES WRP CDS performance testing.

  12. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

    Directory of Open Access Journals (Sweden)

    Dan Xu

    2014-04-01

    Full Text Available Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU] developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would be hepatotoxic in humans. Therefore, we investigated whether FIAU-induced liver toxicity could be detected in chimeric TK-NOG mice with humanized livers.Control and chimeric TK-NOG mice with humanized livers were treated orally with FIAU 400, 100, 25, or 2.5 mg/kg/d. The response to drug treatment was evaluated by measuring plasma lactate and liver enzymes, by assessing liver histology, and by electron microscopy. After treatment with FIAU 400 mg/kg/d for 4 d, chimeric mice developed clinical and serologic evidence of liver failure and lactic acidosis. Analysis of liver tissue revealed steatosis in regions with human, but not mouse, hepatocytes. Electron micrographs revealed lipid and mitochondrial abnormalities in the human hepatocytes in FIAU-treated chimeric mice. Dose-dependent liver toxicity was detected in chimeric mice treated with FIAU 100, 25, or 2.5 mg/kg/d for 14 d. Liver toxicity did not develop in control mice that were treated with the same FIAU doses for 14 d. In contrast, treatment with another nucleotide analogue (sofosbuvir 440 or 44 mg/kg/d po for 14 d, which did not cause liver toxicity in human trial participants, did not cause liver toxicity in mice with humanized livers.FIAU-induced liver toxicity could be readily detected using chimeric TK-NOG mice with humanized livers, even when the mice were treated with a FIAU dose that was only 10-fold above the dose used in human participants. The clinical features, laboratory abnormalities, liver histology, and ultra-structural changes observed in FIAU-treated chimeric mice mirrored those of FIAU-treated human participants. The use of chimeric mice in preclinical toxicology

  13. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

    Science.gov (United States)

    Xu, Dan; Nishimura, Toshi; Nishimura, Sachiko; Zhang, Haili; Zheng, Ming; Guo, Ying-Ying; Masek, Marylin; Michie, Sara A; Glenn, Jeffrey; Peltz, Gary

    2014-04-01

    Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would be hepatotoxic in humans. Therefore, we investigated whether FIAU-induced liver toxicity could be detected in chimeric TK-NOG mice with humanized livers. Control and chimeric TK-NOG mice with humanized livers were treated orally with FIAU 400, 100, 25, or 2.5 mg/kg/d. The response to drug treatment was evaluated by measuring plasma lactate and liver enzymes, by assessing liver histology, and by electron microscopy. After treatment with FIAU 400 mg/kg/d for 4 d, chimeric mice developed clinical and serologic evidence of liver failure and lactic acidosis. Analysis of liver tissue revealed steatosis in regions with human, but not mouse, hepatocytes. Electron micrographs revealed lipid and mitochondrial abnormalities in the human hepatocytes in FIAU-treated chimeric mice. Dose-dependent liver toxicity was detected in chimeric mice treated with FIAU 100, 25, or 2.5 mg/kg/d for 14 d. Liver toxicity did not develop in control mice that were treated with the same FIAU doses for 14 d. In contrast, treatment with another nucleotide analogue (sofosbuvir 440 or 44 mg/kg/d po) for 14 d, which did not cause liver toxicity in human trial participants, did not cause liver toxicity in mice with humanized livers. FIAU-induced liver toxicity could be readily detected using chimeric TK-NOG mice with humanized livers, even when the mice were treated with a FIAU dose that was only 10-fold above the dose used in human participants. The clinical features, laboratory abnormalities, liver histology, and ultra-structural changes observed in FIAU-treated chimeric mice mirrored those of FIAU-treated human participants. The use of chimeric mice in preclinical toxicology studies could improve

  14. Postirradiation examination results for the Irradiation Effects Scoping Test 2

    International Nuclear Information System (INIS)

    Mehner, A.S.

    1977-01-01

    The postirradiation examination results are reported for two rods from the second scoping test (IE-ST-2) of the Nuclear Regulatory Commission Irradiation Effects Program. The rods were irradiated in the in-pile test loop of the Power Burst Facility at the Idaho National Engineering Laboratory. Rod IE-005 was fabricated from fresh fuel and cladding previously irradiated in the Saxton Reactor. Rod IE-006, fabricated from fresh fuel and unirradiated cladding, was equipped with six developmental cladding surface thermocouples. The rods were preconditioned, power ramped, and then subjected to film boiling operation. The performance of the rods and the developmental thermocouples are evaluated from the post irradiation examination results. The effects of prior irradiation damage in cladding are discussed in relation to fuel rod behavior during a power ramp and subsequent film boiling operation

  15. Results of a first beam test of hadron blind trackers

    Energy Technology Data Exchange (ETDEWEB)

    Chen, M. (Laboratory for Nuclear Science, MIT, Cambridge, MA (United States)); Luckey, D. (Laboratory for Nuclear Science, MIT, Cambridge, MA (United States)); Smolin, M. (Laboratory for Nuclear Science, MIT, Cambridge, MA (United States)); Sumorok, K. (Laboratory for Nuclear Science, MIT, Cambridge, MA (United States)); Zhang, X. (Laboratory for Nuclear Science, MIT, Cambridge, MA (United States)); Bolozdynya, A. (ITEP, Moscow (Russian Federation)); Belogurov, S. (ITEP, Moscow (Russian Federation)); Churakov, D. (ITEP, Moscow (Russian Federation)); Koutchenkov, A. (ITEP, Moscow (Russian Federation)); Kovalenko, A. (ITEP, Moscow (Russian Federation)); Kuzichev, V. (ITEP, Moscow (Russian Federation)); Lebedenko, V. (ITEP, Moscow (Russian Federation)); Sheinkman, V. (ITEP, Moscow (Russian Federation)); Smirnov, G. (ITEP, Moscow (Russian Federation)); Safronov, G. (ITEP, Moscow (Russian Federation)); Vinogradov, V. (ITEP, Moscow (Russian Federation)); Giomataris, Y. (IPN,

    1994-07-15

    We describe the experimental results of a new type of electron tracker, called Hadron Blind Detector or HBD. An HBD prototype was tested with gas mixtures of CF[sub 4] with He or Ne and a parallel plate avalanche chamber having a CsI photocathode of eight pads. Beam tests confirm the large Cherenkov light bandwidth in the EUV region that can be obtained with such gas mixtures. It results in a large quality factor of about 500 cm[sup -1] which allows HBD operation with a much shorter radiator thickness than conventional Cherenkov counters. Full electron efficiency was obtained, while pions were rejected up to momenta of 9 GeV/c. HBD is unique in measuring electron trajectories near the vertex, vetoing Dalitz pairs, and providing trigger on electrons among heavy hadron background. We discuss the use of such detectors for lepton identification and detection in high energy physics experiments and especially in heavy ion colliders. ((orig.))

  16. Results of a first beam test of hadron blind trackers

    International Nuclear Information System (INIS)

    Chen, M.; Luckey, D.; Smolin, M.; Sumorok, K.; Zhang, X.; Bolozdynya, A.; Belogurov, S.; Churakov, D.; Koutchenkov, A.; Kovalenko, A.; Kuzichev, V.; Lebedenko, V.; Sheinkman, V.; Smirnov, G.; Safronov, G.; Vinogradov, V.; Giomataris, Y.; Joseph, C.; Werlen, M.; Charpak, G.; Blumenfeld, B.; Gougas, A.K.; Steele, D.; Akopyan, M.

    1994-01-01

    We describe the experimental results of a new type of electron tracker, called Hadron Blind Detector or HBD. An HBD prototype was tested with gas mixtures of CF 4 with He or Ne and a parallel plate avalanche chamber having a CsI photocathode of eight pads. Beam tests confirm the large Cherenkov light bandwidth in the EUV region that can be obtained with such gas mixtures. It results in a large quality factor of about 500 cm -1 which allows HBD operation with a much shorter radiator thickness than conventional Cherenkov counters. Full electron efficiency was obtained, while pions were rejected up to momenta of 9 GeV/c. HBD is unique in measuring electron trajectories near the vertex, vetoing Dalitz pairs, and providing trigger on electrons among heavy hadron background. We discuss the use of such detectors for lepton identification and detection in high energy physics experiments and especially in heavy ion colliders. ((orig.))

  17. Determination of liver and spleen perfusion by quantitative sequential scintigraphy: results in normal subjects and in patients with portal hypertension

    International Nuclear Information System (INIS)

    Biersack, H.J.; Torres, J.; Thelen, M.; Monzon, O.; Winkler, C.

    1981-01-01

    Quantitative sequential hepatosplenic scintigraphy was performed to determine the arterial and portal components of the total liver circulation in 135 patients (no liver disease in 20, liver cirrhosis and portal ;hypertension in 115). Portal circulation in healthy patients is calculated to be 70.4 +/- 6.2% of the total liver blood flow, whereas patients with portal hypertension showed a clear reduction of portal perfusion to 20.2 +/- 10.9%. Thirteen of 20 patients having portosystemic shunt surgery showed no portal perfusion. This new, noninvasive diagnostic technique yields vital information particularly useful in ;the surgical evaluation of portal hypertension. Other indications are also discussed

  18. Summary of Test Results for Daya Bay Rock Samples

    International Nuclear Information System (INIS)

    Onishi, Celia Tiemi; Dobson, Patrick; Nakagawa, Seiji

    2004-01-01

    A series of analytical tests was conducted on a suite of granitic rock samples from the Daya Bay region of southeast China. The objective of these analyses was to determine key rock properties that would affect the suitability of this location for the siting of a neutrino oscillation experiment. This report contains the results of chemical analyses, rock property measurements, and a calculation of the mean atomic weight

  19. Seismic II over I Drop Test Program results and interpretation

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, B.

    1993-03-01

    The consequences of non-seismically qualified (Category 2) objects falling and striking essential seismically qualified (Category 1) objects has always been a significant, yet analytically difficult problem, particularly in evaluating the potential damage to equipment that may result from earthquakes. Analytical solutions for impact problems are conservative and available for mostly simple configurations. In a nuclear facility, the {open_quotes}sources{close_quotes} and {open_quotes}targets{close_quotes} requiring evaluation are frequently irregular in shape and configuration, making calculations and computer modeling difficult. Few industry or regulatory rules are available on this topic even though it is a source of considerable construction upgrade costs. A drop test program was recently conducted to develop a more accurate understanding of the consequences of seismic interactions. The resulting data can be used as a means to improve the judgment of seismic qualification engineers performing interaction evaluations and to develop realistic design criteria for seismic interactions. Impact tests on various combinations of sources and targets commonly found in one Savannah River Site (SRS) nuclear facility were performed by dropping the sources from various heights onto the targets. This report summarizes results of the Drop Test Program. Force and acceleration time history data are presented as well as general observations on the overall ruggedness of various targets when subjected to impacts from different types of sources.

  20. Seismic II over I Drop Test Program results and interpretation

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, B.

    1993-03-01

    The consequences of non-seismically qualified (Category 2) objects falling and striking essential seismically qualified (Category 1) objects has always been a significant, yet analytically difficult problem, particularly in evaluating the potential damage to equipment that may result from earthquakes. Analytical solutions for impact problems are conservative and available for mostly simple configurations. In a nuclear facility, the [open quotes]sources[close quotes] and [open quotes]targets[close quotes] requiring evaluation are frequently irregular in shape and configuration, making calculations and computer modeling difficult. Few industry or regulatory rules are available on this topic even though it is a source of considerable construction upgrade costs. A drop test program was recently conducted to develop a more accurate understanding of the consequences of seismic interactions. The resulting data can be used as a means to improve the judgment of seismic qualification engineers performing interaction evaluations and to develop realistic design criteria for seismic interactions. Impact tests on various combinations of sources and targets commonly found in one Savannah River Site (SRS) nuclear facility were performed by dropping the sources from various heights onto the targets. This report summarizes results of the Drop Test Program. Force and acceleration time history data are presented as well as general observations on the overall ruggedness of various targets when subjected to impacts from different types of sources.

  1. Seismic II over I Drop Test Program results and interpretation

    International Nuclear Information System (INIS)

    Thomas, B.

    1993-03-01

    The consequences of non-seismically qualified (Category 2) objects falling and striking essential seismically qualified (Category 1) objects has always been a significant, yet analytically difficult problem, particularly in evaluating the potential damage to equipment that may result from earthquakes. Analytical solutions for impact problems are conservative and available for mostly simple configurations. In a nuclear facility, the open-quotes sourcesclose quotes and open-quotes targetsclose quotes requiring evaluation are frequently irregular in shape and configuration, making calculations and computer modeling difficult. Few industry or regulatory rules are available on this topic even though it is a source of considerable construction upgrade costs. A drop test program was recently conducted to develop a more accurate understanding of the consequences of seismic interactions. The resulting data can be used as a means to improve the judgment of seismic qualification engineers performing interaction evaluations and to develop realistic design criteria for seismic interactions. Impact tests on various combinations of sources and targets commonly found in one Savannah River Site (SRS) nuclear facility were performed by dropping the sources from various heights onto the targets. This report summarizes results of the Drop Test Program. Force and acceleration time history data are presented as well as general observations on the overall ruggedness of various targets when subjected to impacts from different types of sources

  2. Small-Scale Spray Releases: Additional Aerosol Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Schonewill, Philip P.; Gauglitz, Phillip A.; Kimura, Marcia L.; Brown, G. N.; Mahoney, Lenna A.; Tran, Diana N.; Burns, Carolyn A.; Kurath, Dean E.

    2013-08-01

    One of the events postulated in the hazard analysis at the Waste Treatment and Immobilization Plant (WTP) and other U.S. Department of Energy (DOE) nuclear facilities is a breach in process piping that produces aerosols with droplet sizes in the respirable range. The current approach for predicting the size and concentration of aerosols produced in a spray leak involves extrapolating from correlations reported in the literature. These correlations are based on results obtained from small engineered spray nozzles using pure liquids with Newtonian fluid behavior. The narrow ranges of physical properties on which the correlations are based do not cover the wide range of slurries and viscous materials that will be processed in the WTP and across processing facilities in the DOE complex. To expand the data set upon which the WTP accident and safety analyses were based, an aerosol spray leak testing program was conducted by Pacific Northwest National Laboratory (PNNL). PNNL’s test program addressed two key technical areas to improve the WTP methodology (Larson and Allen 2010). The first technical area was to quantify the role of slurry particles in small breaches where slurry particles may plug the hole and prevent high-pressure sprays. The results from an effort to address this first technical area can be found in Mahoney et al. (2012a). The second technical area was to determine aerosol droplet size distribution and total droplet volume from prototypic breaches and fluids, including sprays from larger breaches and sprays of slurries for which literature data are largely absent. To address the second technical area, the testing program collected aerosol generation data at two scales, commonly referred to as small-scale and large-scale. The small-scale testing and resultant data are described in Mahoney et al. (2012b) and the large-scale testing and resultant data are presented in Schonewill et al. (2012). In tests at both scales, simulants were used to mimic the

  3. The first operation of the Delphos plant: Test results

    International Nuclear Information System (INIS)

    Sarno, A.; Noviello, G.; Cordisco, S.; Di Paola, L.; Guerra, M.

    1991-09-01

    The data collected during the O and M of the Delphos plant and the testing results are presented and discussed. Together with the maintenance influence on the operation and production of the plant, the various downtime causes are pointed out. An extensive activity has been carried out to investigate the actual behaviour of the photovoltaic generator and the power conditioning unit. The analysis of the experimental results allows to focus on the different causes of loss and suggest some actions to be taken in order to improve the plant efficiency and increase the energy production. (author)

  4. Reproducibility problems of in-service ultrasonic testing results

    International Nuclear Information System (INIS)

    Honcu, E.

    1974-01-01

    The reproducibility of the results of ultrasonic testing is the basic precondition for its successful application in in-service inspection of changes in the quality of components of nuclear power installations. The results of periodic ultrasonic inspections are not satisfactory from the point of view of reproducibility. Regardless, the ultrasonic pulse-type method is suitable for evaluating the quality of most components of nuclear installations and often the sole method which may be recommended for inspection with regard to its technical and economic aspects. (J.B.)

  5. Test beam results from a scintillating fibers-lead calorimeter

    International Nuclear Information System (INIS)

    Caria, M.

    1991-01-01

    The SpaCal collaboration has built prototypes of lead-scintillating fibers calorimter. The aim is to check predicted performances. Here are briefly mentioned results obtained from prototypes tests in beam of e, π, μ at CERN. Layers 2m long of extruded lead, were equipped with 1mm fibers in an hexagonal geometry. The ratio of scintillator to lead was 1/4. Results are presented on the most appealing features of such a calorimeter: energy resolution, homogeneity, containment and compensation. It is shown, that excellent energy resolution togehter with compensation has been achieved. (orig.)

  6. Postirradiation examination results for the Irradiation Effects Test 2

    International Nuclear Information System (INIS)

    Ploger, S.A.; Kerwin, D.K.; Croucher, D.W.

    1978-01-01

    This report presents the postirradiation examination results of Test IE-2 in the Irradiation Effects Test Series conducted under the Thermal Fuels Behavior Program. The objectives of this test were to evaluate the influence of previous cladding irradiation and fuel-cladding diametral gap on fuel rod behavior during a power ramp and during film boiling operation. Test IE-2, conducted in the Power Burst Facility at the Idaho National Engineering Laboratory, employed two 0.97-m-long pressurized water reactor type fuel rods fabricated from previously irradiated zircaloy-4 cladding and two similar rods fabricated from unirradiated cladding. The four rods were subjected to a preconditioning period, followed by a power ramp to an average peak rod power of 68 kW/m and steady state operation for one hour at an individual rod coolant mass flux of 4880 kg/s . m 2 . After a flow reduction to 2550 kg/s . m 2 , film boiling occurred on three rods. An additional flow reduction to 2245 kg/s . m 2 produced film boiling on the remaining fuel rod. Maximum time in film boiling was 90 s. None of the four fuel rods failed during the test. Damage caused by film boiling, as characterized by oxidation, oxide spalling, and collapse at fuel pellet interfaces, was found on all four rods. Film boiling regions on these rods showed evidence of fuel melting, fuel centerline void formation, and internal cladding oxidation resulting from fuel-cladding reaction. Effects of fuel-cladding diametral gap and cladding irradiation are summarized. Measured temperatures and metallographically estimated temperatures are compared at several axial fuel rod locations

  7. Viability testing and transplantation of marginal livers (VITTAL) using normothermic machine perfusion: study protocol for an open-label, non-randomised, prospective, single-arm trial.

    Science.gov (United States)

    Laing, Richard W; Mergental, Hynek; Yap, Christina; Kirkham, Amanda; Whilku, Manpreet; Barton, Darren; Curbishley, Stuart; Boteon, Yuri L; Neil, Desley A; Hübscher, Stefan G; Perera, M Thamara P R; Muiesan, Paolo; Isaac, John; Roberts, Keith J; Cilliers, Hentie; Afford, Simon C; Mirza, Darius F

    2017-11-28

    The use of marginal or extended criteria donor livers is increasing. These organs carry a greater risk of initial dysfunction and early failure, as well as inferior long-term outcomes. As such, many are rejected due to a perceived risk of use and use varies widely between centres. Ex situ normothermic machine perfusion of the liver (NMP-L) may enable the safe transplantation of organs that meet defined objective criteria denoting their high-risk status and are currently being declined for use by all the UK transplant centres. Viability testing and transplantation of marginal livers is an open-label, non-randomised, prospective, single-arm trial designed to determine whether currently unused donor livers can be salvaged and safely transplanted with equivalent outcomes in terms of patient survival. The procured rejected livers must meet predefined criteria that objectively denote their marginal condition. The liver is subjected to NMP-L following a period of static cold storage. Organs metabolising lactate to ≤2.5 mmol/L within 4 hours of the perfusion commencing in combination with two or more of the following parameters-bile production, metabolism of glucose, a hepatic arterial flow rate ≥150 mL/min and a portal venous flow rate ≥500 mL/min, a pH ≥7.30 and/or maintain a homogeneous perfusion-will be considered viable and transplanted into a suitable consented recipient. The coprimary outcome measures are the success rate of NMP-L to produce a transplantable organ and 90-day patient post-transplant survival. The protocol was approved by the National Research Ethics Service (London-Dulwich Research Ethics Committee, 16/LO/1056), the Medicines and Healthcare Products Regulatory Agency and is endorsed by the National Health Service Blood and Transplant Research, Innovation and Novel Technologies Advisory Group. The findings of this trial will be disseminated through national and international presentations and peer-reviewed publications. NCT02740608

  8. Test results of sodium-water reaction testing in near prototypical LMR steam generator

    International Nuclear Information System (INIS)

    Boardman, C.E.; Hui, M.; Neely, H.H.

    1990-01-01

    An extensive test program has been performed in the United States to investigate the effects of large sodium-water reaction events in LMFBR steam generators. Tests were conducted in the Large Leak Test Rig (LLTR) located at the Energy Technology Engineering Center (ETEC). The program was divided into two phases, Series I and Series II, for the purpose of satisfying near-term and long-term needs. Series II was further subdivided into large and intermediate leak tests. This paper will emphasize the Series II intermediate leak tests and resulting conclusions for steam generator design and operation. 11 figs, 2 tabs

  9. Challenges in interpretation of thyroid hormone test results

    Directory of Open Access Journals (Sweden)

    Lalić Tijana

    2016-01-01

    Full Text Available Introduction. In interpreting thyroid hormones results it is preferable to think of interference and changes in concentration of their carrier proteins. Outline of Cases. We present two patients with discrepancy between the results of thyroid function tests and clinical status. The first case presents a 62-year-old patient with a nodular goiter and Hashimoto thyroiditis. Thyroid function test showed low thyroid-stimulating hormone (TSH and normal to low fT4. By determining thyroid status (ТSH, T4, fT4, T3, fT3 in two laboratories, basal and after dilution, as well as thyroxine-binding globulin (TBG, it was concluded that the thyroid hormone levels were normal. The results were influenced by heterophile antibodies leading to a false lower TSH level and suspected secondary hypothyroidism. The second case, a 40-year-old patient, was examined and followed because of the variable size thyroid nodule and initially borderline elevated TSH, after which thyroid status showed low level of total thyroid hormones and normal TSH. Based on additional analysis it was concluded that low T4 and T3 were a result of low TBG. It is a hereditary genetic disorder with no clinical significance. Conclusion. Erroneous diagnosis of thyroid disorders and potentially harmful treatment could be avoided by proving the interference or TBG deficiency whenever there is a discrepancy between the thyroid function results and the clinical picture.

  10. Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis.

    Science.gov (United States)

    Ogawa, Saori; Moriyasu, Fuminori; Yoshida, Keiko; Oshiro, Hisashi; Kojima, Mayumi; Sano, Takatomo; Furuichi, Yoshihiro; Kobayashi, Yoshiyuki; Nakamura, Ikuo; Sugimoto, Katsutoshi

    2016-07-01

    The aim of the present study was to investigate two methods of determining liver stiffness in rats with various degrees of non-alcoholic steatohepatitis induced by a methionine- and choline-deficient (MCD) diet by comparing each finding with reference to histopathological liver findings. Twenty male Wister rats were fed an MCD diet for up to 32 weeks, and four were fed a normal diet. Ultrasound-based shear wave elastography (SWE) and mechanical compression testing using an Instron Universal Testing machine were performed on each rat at designated time points. After each examination, liver histopathology was analyzed to evaluate the degrees of steatosis, inflammation, and fibrosis based on non-alcoholic fatty liver disease (NAFLD) activity score, and each finding was compared with reference to liver histopathologic findings. Median liver stiffness values measured using SWE showed a stepwise increase with increasing histological inflammation score (P = 0.002), hepatic fibrosis stage (P = 0.029), ballooning score (P = 0.012), and steatosis grade (P = 0.030). Median liver stiffness measured using an Instron machine showed a stepwise increase only with increasing histological fibrosis stage (P = 0.033). Degree of liver stiffness measured by SWE and the Instron machine differed. SWE reflected mainly inflammation, whereas Instron machine-derived values primarily reflected fibrosis. This is the main source of discrepancies between measurements made with these two modalities.

  11. Automation and results of Adjacent Band Emission testing

    Science.gov (United States)

    2015-03-01

    Problem Statement : Multiple groups conduct tests in various ways - Outcomes vary based on test setup and assumptions - No standard has been established to conduct such tests - Spectrum is scarce and the need for compliance testing will only increase...

  12. Postirradiation examination results for the Irradiation Effects Test IE-5

    International Nuclear Information System (INIS)

    Cook, T.F.; Ploger, S.A.; Hobbins, R.R.

    1978-03-01

    The results are presented of the postirradiation examination of four pressurized water reactor type fuel rods which were tested in-pile under a fast power ramp and film boiling operation during Irradiation Effects (IE) Test 5. The major objectives of this test were to evaluate the effects of simulated fission products on fuel rod behavior during a fast power ramp, to determine the effects of high initial internal pressure on a fuel rod during film boiling, and to assess fuel rod property changes that occur during film boiling in a fuel rod with previously irradiated cladding. The overall condition of the rods and changes that occurred in fuel and cladding as a result of the power ramp and film boiling operation, as determined from the postirradiation examination, are reported and analyzed. Effects of the simulated fission products on fuel rod behavior during a power ramp are discussed. The effect of high internal pressure on rod behavior during film boiling is evaluated. Cladding temperatures are estimated at various axial and circumferential locations. Cladding embrittlement by oxidation is also assessed

  13. Benchmark Calculations on Halden IFA-650 LOCA Test Results

    International Nuclear Information System (INIS)

    Ek, Mirkka; Kekkonen, Laura; Kelppe, Seppo; Stengaard, J.O.; Josek, Radomir; Wiesenack, Wolfgang; Aounallah, Yacine; Wallin, Hannu; Grandjean, Claude; Herb, Joachim; Lerchl, Georg; Trambauer, Klaus; Sonnenburg, Heinz-Guenther; Nakajima, Tetsuo; Spykman, Gerold; Struzik, Christine

    2010-01-01

    through several blow-downs and heat-ups and reached peak clad temperatures of more than 1000 C. In the second run, where the rod was sufficiently pre-pressurised, ballooning and burst was obtained. The first benchmark consisted of three rounds of code calculations related to IFA-650.3: 1. Pre-test calculations: Participants were provided with information regarding the setup of the Halden LOCA test facility, data from the commissioning runs, and information about the test pin and power conditions to be applied in the execution of the test. 2. Post-test calculations I: In addition to the information from the first round, participants were provided with the in-pile results from the test. 3. Post-test calculations II, unified thermal-hydraulic boundary conditions: Calculations were repeated using a cladding temperature distribution calculated with ATHLET-CD at GRS. Since the test, when executed, did not produce the expected ballooning and fuel relocation, it was decided to continue with a second benchmark using tests 650.4 and 650.5, this time as post-test calculations. The fourth test of the series, IFA-650.4 conducted in April 2006, caused particular attention in the international nuclear community. The fuel used in the experiment had a high burnup, 92 MWd/kgU, and a low pre-test hydrogen content of about 50 ppm. The cladding burst at about 790 deg. C caused a marked temperature increase at the lower end of the segment and a decrease at the upper end, indicating that fuel relocation had occurred. Subsequent gamma scanning showed that approximately 19 cm (40%) of the fuel stack were missing from the upper part of the rod. PIE at the IFE-Kjeller hot cells corroborated this evidence of substantial fuel relocation. This report presents the results of the codes which participated in the various benchmarks. The two main parts, on benchmark I and II, each start with a brief description of the most important experimental data. Then, the code calculation results follow

  14. Structural damping results from vibration tests of straight piping sections

    International Nuclear Information System (INIS)

    Ware, A.G.; Thinnes, G.L.

    1984-01-01

    EG and G Idaho is assisting the USNRC and the Pressure Vessel Research Committee in supporting a final position on revised damping values for structural analyses of nuclear piping systems. As part of this program, a series of vibrational tests on 76-mm and 203-mm (3-in. amd 8-in.) Schedule 40 carbon steel piping was conducted to determine the changes in structural damping due to various parametric effects. The 10-m (33-ft) straight sections of piping were rigidly supported at the ends. Spring, rod, and constant force hangers, as well as a sway brace and snubbers were included as intermediate supports. Excitation was provided by low-force level hammer inpacts, a hydraulic shaker, and a 445-kN (50-ton) overhead crane. Data was recorded using acceleration, strain, and displacement time histories. This paper presents results from the testing showing the effect of stress level and type of supports on structural damping in piping

  15. LEDA RF distribution system design and component test results

    International Nuclear Information System (INIS)

    Roybal, W.T.; Rees, D.E.; Borchert, H.L.; McCarthy, M.; Toole, L.

    1998-01-01

    The 350 MHz and 700 MHz RF distribution systems for the Low Energy Demonstration Accelerator (LEDA) have been designed and are currently being installed at Los Alamos National Laboratory. Since 350 MHz is a familiar frequency used at other accelerator facilities, most of the major high-power components were available. The 700 MHz, 1.0 MW, CW RF delivery system designed for LEDA is a new development. Therefore, high-power circulators, waterloads, phase shifters, switches, and harmonic filters had to be designed and built for this applications. The final Accelerator Production of Tritium (APT) RF distribution systems design will be based on much of the same technology as the LEDA systems and will have many of the RF components tested for LEDA incorporated into the design. Low power and high-power tests performed on various components of these LEDA systems and their results are presented here

  16. Experimental results of some cluster tests in NSRR

    International Nuclear Information System (INIS)

    Kobayashi, Shinsho; Ohnishi, Nobuaki; Yoshimura, Tomio; Lussie, W.G.

    1978-01-01

    The NSRR programme is in progress in JAERI using a pulsed reactor to evaluate the behavior of reactor fuels under reactivity accident conditions. This report describes briefly the experimental results and preliminary analysis of two cluster tests. In the cluster configuration of five fuel rods, the power distribution in outer fuel rods are not symmetric due to neutron absorption in central fuel rod. The cladding temperature on the exterior boundaries of the cluster is higher than that in interior. Good agreement was obtained between the calculated and measured cladding temperature histories. In the 3.8$ excess reactivity test, cluster averaged energy deposition of 237 cal/g.UO 2 , cladding melting and deformation were limited to the portions of the fuel rods that were on the exterior boundaries of the cluster. (auth.)

  17. Preliminary Results of Testing of Flow Effects on Evaporator Scaling

    Energy Technology Data Exchange (ETDEWEB)

    Hu, M.Z.

    2002-02-15

    This investigation has focused on the effects of fluid flow on solids deposition from solutions that simulate the feed to the 2H evaporator at the Savannah River Site. Literature studies indicate that the fluid flow (or shear) affects particle-particle and particle-surface interactions and thus the phenomena of particle aggregation in solution and particle deposition (i.e., scale formation) onto solid surfaces. Experimental tests were conducted with two configurations: (1) using a rheometer to provide controlled shear conditions and (2) using controlled flow of reactive solution through samples of stainless steel tubing. All tests were conducted at 80 C and at high silicon and aluminum concentrations, 0.133 M each, in solutions containing 4 M sodium hydroxide and 1 A4 each of sodium nitrate and sodium nitrite. Two findings from these experiments are important for consideration in developing approaches for reducing or eliminating evaporator scaling problems: (1) The rheometer tests suggested that for the conditions studied, maximum solids deposition occurs at a moderate shear rate, approximately 12 s{sup -1}. That value is expected to be on the order of shear rates that will occur in various parts of the evaporator system; for instance, a 6 gal/min single-phase liquid flow through the 2-in. lift or gravity drain lines would result in a shear rate of approximately 16 s{sup -1}. These results imply that engineering approaches aimed at reducing deposits through increased mixing would need to generate shear near all surfaces significantly greater than 12 s{sup -1}. However, further testing is needed to set a target value for shear that is applicable to evaporator operation. This is because the measured trend is not statistically significant at the 95% confidence interval due to variability in the results. In addition, testing at higher temperatures and lower concentrations of aluminum and silicon would more accurately represent conditions in the evaporator. Without

  18. LWR surveillance dosimetry improvement program: PSF metallurgical blind test results

    International Nuclear Information System (INIS)

    Kam, F.B.K.; Maerker, R.E.; Stallmann, F.W.

    1984-01-01

    The metallurgical irradiation experiment at the Oak Ridge Research Reactor Poolside Facility (ORR-PSF) was designed as a benchmark to test the accuracy of radiation embrittlement predictions in the pressure vessel wall of light water reactors on the basis of results from surveillance capsules. The PSF metallurgical Blind Test is concerned with the simulated surveillance capsule (SSC) and the simulated pressure vessel capsule (SPVC). The data from the ORR-PSF benchmark experiment are the basis for comparison with the predictions made by participants of the metallurgical ''Blind Test''. The Blind Test required the participants to predict the embrittlement of the irradiated specimen based only on dosimetry and metallurgical data from the SSC1 capsule. This exercise included both the prediction of damage fluence and the prediction of embrittlement based on the predicted fluence. A variety of prediction methodologies was used by the participants. No glaring biases or other deficiencies were found, but neither were any of the methods clearly superior to the others. Closer analysis shows a rather complex and poorly understood relation between fluence and material damage. Many prediction formulas can give an adequate approximation, but further improvement of the prediction methodology is unlikely at this time given the many unknown factors. Instead, attention should be focused on determining realistic uncertainties for the predicted material changes. The Blind Test comparisons provide some clues for the size of these uncertainties. In particular, higher uncertainties must be assigned to materials whose chemical composition lies outside the data set for which the prediction formula was obtained. 16 references, 14 figures, 5 tables

  19. Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats

    NARCIS (Netherlands)

    Fisher, Craig D.; Lickteig, Andrew J.; Augustine, Lisa M.; Oude Elferink, Ronald P. J.; Besselsen, David G.; Erickson, Robert P.; Cherrington, Nathan J.

    2009-01-01

    Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diagnoses ranging from simple fatty liver (SFL), to non-alcoholic steatohepatitis (NASH). This study aimed to determine the effect of moderate and severe NAFLD on hepatic transporter expression and function in vivo. Rats were fed a

  20. Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

    Science.gov (United States)

    Takasawa, Hironao; Suzuki, Hiroshi; Ogawa, Izumi; Shimada, Yasushi; Kobayashi, Kazuo; Terashima, Yukari; Matsumoto, Hirotaka; Aruga, Chinami; Oshida, Keiyu; Ohta, Ryo; Imamura, Tadashi; Miyazaki, Atsushi; Kawabata, Masayoshi; Minowa, Shigenori; Hayashi, Makoto

    2010-04-30

    We have been investigating a liver micronucleus assay to detect genotoxic chemicals using young rats for several years, and had established its advantages with respect to using autonomous proliferation of young rat hepatocytes. Nine chemicals known to induce hepatotoxic effects such as necrosis (2,6-dinitrotolune, bromobenzene, isoniazid, phenacetin, allyl alcohol and thioacetamide), cholestasis (chlorpromazine hydrochloride and alpha-naphthyl isothiocyanate) and oxidative stress (clofibrate) were selected for this study. A liver micronucleus assay was conducted in 4-week-old male F344 rats using two or three dose levels of test chemicals given orally by gavage to evaluate the compound's ability to induce micronucleated hepatocytes. Several of these test chemicals were additionally examined in a peripheral blood micronucleus assay conducted concurrently and in the same animals. The genotoxic rodent hepatocarcinogen, 2,6-dinitrotoluene showed a positive result in the liver micronucleus assay, but the nongenotoxic hepatocarcinogens, clofibrate and thioacetamide gave negative responses. Bromobenzene, known to produce DNA adducts but is noncarcinogenic in rodent liver, was judged equivocal in this assay. alpha-Naphthyl isothiocyanate is noncarcinogenic and showed negative response in the liver. The other four chemicals, known to be either noncarcinogenic or carcinogenic in other non-liver target organs, showed negative results in the liver micronucleus assay. Based on the results in the present study and previous report described above, it was concluded that this technique is able to effectively predict genotoxic rodent hepatocarcinogenicity, and does not give false positives due to hepatotoxicity. Copyright 2010 Elsevier B.V. All rights reserved.

  1. Relationship between hepatic CTGF expression and routine blood tests at the time of liver transplantation for biliary atresia: hope or hype for a biomarker of hepatic fibrosis

    Directory of Open Access Journals (Sweden)

    Haafiz A

    2011-04-01

    Full Text Available Allah Haafiz1, Christian Farrington1, Joel Andres1, Saleem Islam21Hepatology and Liver Transplantation, Division of Pediatric Gastroenterology, Hepatology and Nutrition, 2Division of Pediatric Surgery, University of Florida College of Medicine, Gainesville, FL, USABackground: Progressive hepatic fibrosis (HF is a prominent feature of biliary atresia (BA, the most common indication for liver transplantation (LT in children. Despite its importance in BA, HF is not evaluated in routine patient care because the invasiveness of liver biopsy makes histologic monitoring of fibrosis unfeasible. Therefore, the identification of noninvasive markers to assess HF is desirable especially in children.Purpose: The main goal of this pilot project was to establish an investigational framework correlating hepatic expression of fibrogenic markers with routine blood tests in BA.Methods: Using liver explants from patients with BA (n = 26, immune-expression of connective tissue growth factor (CTGF, a key fibrogenic cytokine was determined using horseradish-labeled antibodies. Expression intensities of lobular (L-CTGF and portal (P-CTGF CTGF were determined by using ImageJ software. These CTGF intensities were correlated with blood tests performed at the time of LT. Correlation coefficients were determined for each blood test variable versus mean L-CTGF and P-CTGF expression intensities. A P-value of less than 0.05 was considered statistically significant.Results: All patients had end-stage liver disease and persistent cholestasis at the time of LT. Kendall tau (t rank correlation coefficient for L-CTGF and white blood cell (WBC was inversed (—0.52; P ≤ 0.02. Similar but statistically nonsignificant inverse relationships were noted between L-CTGF and prothrombin time (PT (—0.15; P ≤ 0.4, international normalized ratio (INR (—0.14; P ≤ 0.5, and platelet count (—0.36; P ≤ 0.09. Inversed (t rank correlation coefficients were also evident between P

  2. Results of Large-Scale Spacecraft Flammability Tests

    Science.gov (United States)

    Ferkul, Paul; Olson, Sandra; Urban, David L.; Ruff, Gary A.; Easton, John; T'ien, James S.; Liao, Ta-Ting T.; Fernandez-Pello, A. Carlos; Torero, Jose L.; Eigenbrand, Christian; hide

    2017-01-01

    For the first time, a large-scale fire was intentionally set inside a spacecraft while in orbit. Testing in low gravity aboard spacecraft had been limited to samples of modest size: for thin fuels the longest samples burned were around 15 cm in length and thick fuel samples have been even smaller. This is despite the fact that fire is a catastrophic hazard for spaceflight and the spread and growth of a fire, combined with its interactions with the vehicle cannot be expected to scale linearly. While every type of occupied structure on earth has been the subject of full scale fire testing, this had never been attempted in space owing to the complexity, cost, risk and absence of a safe location. Thus, there is a gap in knowledge of fire behavior in spacecraft. The recent utilization of large, unmanned, resupply craft has provided the needed capability: a habitable but unoccupied spacecraft in low earth orbit. One such vehicle was used to study the flame spread over a 94 x 40.6 cm thin charring solid (fiberglasscotton fabric). The sample was an order of magnitude larger than anything studied to date in microgravity and was of sufficient scale that it consumed 1.5 of the available oxygen. The experiment which is called Saffire consisted of two tests, forward or concurrent flame spread (with the direction of flow) and opposed flame spread (against the direction of flow). The average forced air speed was 20 cms. For the concurrent flame spread test, the flame size remained constrained after the ignition transient, which is not the case in 1-g. These results were qualitatively different from those on earth where an upward-spreading flame on a sample of this size accelerates and grows. In addition, a curious effect of the chamber size is noted. Compared to previous microgravity work in smaller tunnels, the flame in the larger tunnel spread more slowly, even for a wider sample. This is attributed to the effect of flow acceleration in the smaller tunnels as a result of hot

  3. MRI findings in acute hyperammonemic encephalopathy resulting from decompensated chronic liver disease.

    Science.gov (United States)

    Sureka, Jyoti; Jakkani, Ravi Kanth; Panwar, Sanuj

    2012-06-01

    Hyperammonemic encephalopathy is a type of metabolic encephalopathy with diversified etiology. Hyperammonemia is the end result of several metabolic disorders such as congenital deficiencies of urea cycle enzymes, hepatic encephalopathy, Reye's syndrome and other toxic encephalopathies. Non-specific clinical presentation poses a great challenge in early diagnosis of this entity. Irrespective of the underlying etiology, hyperammonemia causes a distinctive pattern of brain parenchymal injury. The cingulate gyrus and insular cortex are more vulnerable to this type of toxic insult. Characteristic magnetic resonance imaging findings in combination with laboratory parameters can help to differentiate this entity from other metabolic encephalopathy and thus aiding in early diagnosis and treatment.

  4. Automotive RF immunity test set-up analysis : why test results can't compare

    NARCIS (Netherlands)

    Coenen, Mart; Pues, H.; Bousquet, T.

    2011-01-01

    Though the automotive RF emission and RF immunity requirements are highly justifiable, the application of those requirements in an non-intended manner leads to false conclusions and unnecessary redesigns for the electronics involved. When the test results become too dependent upon the test set-up

  5. Expose : procedure and results of the joint experiment verification tests

    Science.gov (United States)

    Panitz, C.; Rettberg, P.; Horneck, G.; Rabbow, E.; Baglioni, P.

    The International Space Station will carry the EXPOSE facility accommodated at the universal workplace URM-D located outside the Russian Service Module. The launch will be affected in 2005 and it is planned to stay in space for 1.5 years. The tray like structure will accomodate 2 chemical and 6 biological PI-experiments or experiment systems of the ROSE (Response of Organisms to Space Environment) consortium. EXPOSE will support long-term in situ studies of microbes in artificial meteorites, as well as of microbial communities from special ecological niches, such as endolithic and evaporitic ecosystems. The either vented or sealed experiment pockets will be covered by an optical filter system to control intensity and spectral range of solar UV irradiation. Control of sun exposure will be achieved by the use of individual shutters. To test the compatibility of the different biological systems and their adaptation to the opportunities and constraints of space conditions a profound ground support program has been developed. The procedure and first results of this joint Experiment Verification Tests (EVT) will be presented. The results will be essential for the success of the EXPOSE mission and have been done in parallel with the development and construction of the final hardware design of the facility. The results of the mission will contribute to the understanding of the organic chemistry processes in space, the biological adaptation strategies to extreme conditions, e.g. on early Earth and Mars, and the distribution of life beyond its planet of origin.

  6. [Liver transplantation].

    Science.gov (United States)

    Pompili, Maurizio; Mirante, Vincenzo Giorgio; Rapaccini, Gian Ludovico; Gasbarrini, Giovanni

    2004-01-01

    Liver transplantation represents the first choice treatment for patients with fulminant acute hepatitis and for patients with chronic liver disease and advanced functional failure. Patients in the waiting list for liver transplantation are classified according to the severity of their clinical conditions (evaluated using staging systems mostly based on hematochemical parameters related to liver function). This classification, together with the blood group and the body size compatibility, remains the main criterion for organ allocation. The main indications for liver transplantation are cirrhosis (mainly HCV-, HBV- and alcohol-related) and hepatocellular carcinoma emerging in cirrhosis in adult patients, biliary atresia and some inborn errors of metabolism in pediatric patients. In adults the overall 5-year survival ranges between 60 and 70%, in both American and European series. Even better results have been reported for pediatric patients: in fact, the 5-year survival rate for children ranges between 70 and 80% in the main published series. In this study we evaluated the main medical problems correlated with liver transplantation such as immunosuppressive treatment, acute and chronic rejection, infectious complications, the recurrence of the liver disease leading to transplantation, and cardiovascular and metabolic complications.

  7. Hanford coring bit temperature monitor development testing results report

    International Nuclear Information System (INIS)

    Rey, D.

    1995-05-01

    Instrumentation which directly monitors the temperature of a coring bit used to retrieve core samples of high level nuclear waste stored in tanks at Hanford was developed at Sandia National Laboratories. Monitoring the temperature of the coring bit is desired to enhance the safety of the coring operations. A unique application of mature technologies was used to accomplish the measurement. This report documents the results of development testing performed at Sandia to assure the instrumentation will withstand the severe environments present in the waste tanks

  8. Solar energy characteristics and some photovoltaic testing results in Jeddah

    Energy Technology Data Exchange (ETDEWEB)

    Mosalam Shaltout, M A

    1986-01-01

    The data for global radiation were analysed to investigate the correlation with climatological factors. Solar cell module testing under Jeddah climatic conditions was initiated in 1984-1985. The goal of this work was to study the performance and reliability of a commercially-available module in outdoor conditions in order to obtain information on solar cell system design, and to observe the influence of our specific climate conditions on module energy output. The use of results obtained for precise system sizing is discussed.

  9. Plutonium immobilization program - Cold pour Phase 1 test results

    International Nuclear Information System (INIS)

    Hamilton, L.

    2000-01-01

    The Plutonium Immobilization Project will disposition excess weapons grade plutonium. It uses the can-in-canister approach that involves placing plutonium-ceramic pucks in sealed cans that are then placed into Defense Waste Processing Facility canisters. These canisters are subsequently filled with high-level radioactive waste glass. This process puts the plutonium in a stable form and makes it unattractive for reuse. A cold (non-radioactive) glass pour program was performed to develop and verify the baseline design for the canister and internal hardware. This paper describes the Phase 1 scoping test results

  10. Preliminary Results of Breakwater Round-Head Tests

    DEFF Research Database (Denmark)

    Burcharth, H. F.; Liu, Z.

    1995-01-01

    The rational design diagram for Dolos armour should incorporate both the hydraulic stability and the structural integrity. The previous tests performed by Aalborg University (AU) made available such design diagram for the trunk of Dolos breakwater without superstructures (Burcharth et al. 1992). ...... layer will be generated. Furthermore, Task IA will give the design diagram for the trunk of Tetrapod breakwaters. The more complete research results on Dolosse can certainly give some insight into the behaviour of Tetrapods armour layer of the breakwaters with superstructure....

  11. Test Beam Results of Geometry Optimized Hybrid Pixel Detectors

    CERN Document Server

    Becks, K H; Grah, C; Mättig, P; Rohe, T

    2006-01-01

    The Multi-Chip-Module-Deposited (MCM-D) technique has been used to build hybrid pixel detector assemblies. This paper summarises the results of an analysis of data obtained in a test beam campaign at CERN. Here, single chip hybrids made of ATLAS pixel prototype read-out electronics and special sensor tiles were used. They were prepared by the Fraunhofer Institut fuer Zuverlaessigkeit und Mikrointegration, IZM, Berlin, Germany. The sensors feature an optimized sensor geometry called equal sized bricked. This design enhances the spatial resolution for double hits in the long direction of the sensor cells.

  12. Test results of the UNK superconducting dipole magnets

    International Nuclear Information System (INIS)

    Ageev, A.I.; Andreev, N.I.; Gridasov, V.I.

    1993-01-01

    Results of studied, training, temperature and velocity dependence of 25 critical current of superconducting magnets (SC), as well as, of dynamic losses of dipole and statical inflows in UNK operating cycle at currents that are higher than critical ones (5250 A), are presented. Service life tests of SC-dipole demonstrated that their design may ensure durable operation of magnets under UNK conditions. Conclusions are made that temperature margin of magnets equal to 0.8 K will enable to ensure their reliable operation under dynamic and radiation heat releases at acceleration and extraction of beam, as well as, under emergency extraction of stored energy. 4 refs.; 5 figs

  13. Plutonium Immobilization Program - Cold pour Phase 1 test results

    International Nuclear Information System (INIS)

    Hamilton, L.

    2000-01-01

    The Plutonium Immobilization Project will disposition excess weapons grade plutonium. It uses the can-in-canister approach that involves placing plutonium-ceramic pucks in sealed cans that are then placed into Defense Waste Processing Facility canisters. These canisters are subsequently filled with high-level radioactive waste glass. This process puts the plutonium in a stable form and makes it unattractive for reuse. A cold (non-radioactive) glass pour program was performed to develop and verify the baseline design for the canister and internal hardware. This paper describes the Phase 1 scoping test results

  14. Results from Field Testing the RIMFAX GPR on Svalbard.

    Science.gov (United States)

    Hamran, S. E.; Amundsen, H. E. F.; Berger, T.; Carter, L. M.; Dypvik, H.; Ghent, R. R.; Kohler, J.; Mellon, M. T.; Nunes, D. C.; Paige, D. A.; Plettemeier, D.; Russell, P.

    2017-12-01

    The Radar Imager for Mars' Subsurface Experiment - RIMFAX is a Ground Penetrating Radar being developed for NASÁs MARS 2020 rover mission. The principal goals of the RIMFAX investigation are to image subsurface structures, provide context for sample sites, derive information regarding subsurface composition, and search for ice or brines. In meeting these goals, RIMFAX will provide a view of the stratigraphic section and a window into the geological and environmental history of Mars. To verify the design an Engineering Model (EM) of the radar was tested in the field in the spring 2017. Different sounding modes on the EM were tested in different types of subsurface geology on Svalbard. Deep soundings were performed on polythermal glaciers down to a couple of hundred meters. Shallow soundings were used to map a ground water table in the firn area of a glacier. A combination of deep and shallow soundings was used to image buried ice under a sedimentary layer of a couple of meters. Subsurface sedimentary layers were imaged down to more than 20 meters in sand stone permafrost. This presentation will give an overview of the RIMFAX investigation, describe the development of the radar system, and show results from field tests of the radar.

  15. Bridge Testing With Ground-Based Interferometric Radar: Experimental Results

    International Nuclear Information System (INIS)

    Chiara, P.; Morelli, A.

    2010-01-01

    The research of innovative non-contact techniques aimed at the vibration measurement of civil engineering structures (also for damage detection and structural health monitoring) is continuously directed to the optimization of measures and methods. Ground-Based Radar Interferometry (GBRI) represents the more recent technique available for static and dynamic control of structures and ground movements.Dynamic testing of bridges and buildings in operational conditions are currently performed: (a) to assess the conformity of the structure to the project design at the end of construction; (b) to identify the modal parameters (i.e. natural frequencies, mode shapes and damping ratios) and to check the variation of any modal parameters over the years; (c) to evaluate the amplitude of the structural response to special load conditions (i.e. strong winds, earthquakes, heavy railway or roadway loads). If such tests are carried out by using a non-contact technique (like GBRI), the classical issues of contact sensors (like accelerometers) are easily overtaken.This paper presents and discusses the results of various tests carried out on full-scale bridges by using a Stepped Frequency-Continuous Wave radar system.

  16. Bridge Testing With Ground-Based Interferometric Radar: Experimental Results

    Science.gov (United States)

    Chiara, P.; Morelli, A.

    2010-05-01

    The research of innovative non-contact techniques aimed at the vibration measurement of civil engineering structures (also for damage detection and structural health monitoring) is continuously directed to the optimization of measures and methods. Ground-Based Radar Interferometry (GBRI) represents the more recent technique available for static and dynamic control of structures and ground movements. Dynamic testing of bridges and buildings in operational conditions are currently performed: (a) to assess the conformity of the structure to the project design at the end of construction; (b) to identify the modal parameters (i.e. natural frequencies, mode shapes and damping ratios) and to check the variation of any modal parameters over the years; (c) to evaluate the amplitude of the structural response to special load conditions (i.e. strong winds, earthquakes, heavy railway or roadway loads). If such tests are carried out by using a non-contact technique (like GBRI), the classical issues of contact sensors (like accelerometers) are easily overtaken. This paper presents and discusses the results of various tests carried out on full-scale bridges by using a Stepped Frequency-Continuous Wave radar system.

  17. Results of Ageing Tests on the Forward MSGC 'BANANA' Prototype

    CERN Document Server

    Boimska, B; Capéans-Garrido, M; Claes, S; Hoch, Michael; Million, Gilbert; Ropelewski, Leszek; Sharma, Abhishek; Shekhtman, L I; Van Doninck, Walter; Van Lancker, Luc

    1996-01-01

    The forward tracker of the CMS experiment at CERN will consist of a large number of MicroStrip Gas Chambers ( MSGCs), expected to operate for several years in the high luminosity environment of LHC with an accumulated dose rate of ~ 10 mC/yr per cm of strip. They are planned to be arranged around the interaction point in modular wheels which contain several MSGCs. The 'open'option of a forward CMS 'banana' module includes the electronics inside the gas volume. Long term tests of one such prototype containing two plates, one with gold and the other with chromium strips on diamond-like coated D263 glass with representative electronics and surface mount components inside the gas volume have been performed; the satisfactory results are reported here. A first test has been made with a gas flow rate of 60 cc/min in the prototype ( corresponding to 5 gas renewals per hour) and has shown no gain drop up to 85 mC/cm of accumulated charge per strip. A second test has been performed with a gas flow rate of 6 cc/min corr...

  18. Hydrologic testing methodology and results from deep basalt boreholes

    International Nuclear Information System (INIS)

    Strait, S.R.; Spane, F.A.; Jackson, R.L.; Pidcoe, W.W.

    1982-05-01

    The objective of the hydrologic field-testing program is to provide data for characterization of the groundwater systems wihin the Pasco Basin that are significant to understanding waste isolation. The effort is directed toward characterizing the areal and vertical distributions of hydraulic head, hydraulic properties, and hydrochemistry. Data obtained from these studies provide input for numerical modeling of groundwater flow and solute transport. These models are then used for evaluating potential waste migration as a function of space and time. The groundwater system beneath the Hanford Site and surrounding area consists of a thick, accordantly layered sequence of basalt flows and associated sedimentary interbed that primarily occur in the upper part of the Columbia River basalt. Permeable horizons of the sequence are associated with the interbeds and the interflow zones within the basalt. The columnar interiors of a flow act as low-permeability aquitards, separating the more-permeable interflows or interbeds. This paper discusses the hydrologic field-gathering activities, specifically, field-testing methodology and test results from deep basalt boreholes

  19. Test results of the AGS Booster low frequency RF system

    International Nuclear Information System (INIS)

    Sanders, R.T.; Cameron, P.; Damm, R.; Dunbar, A.; Goldman, M.; Kasha, D.; McNerney, A.; Meth, M.; Ratti, A.; Spitz, R.

    1993-01-01

    The Band II RF system was originally built to support the Booster operations during the acceleration of heavy ions. Designed to sweep from 0.6 to 2.5 MHz, it was build and successfully tested over a much broader range reaching 4 MHz. Voltages up to more than 20 kV were reached over the design frequency range. The system consists of two stations, each of which is made of one single gap cavity directly driven by a grounded cathode push pull power amplifier. The low Q high permeability ferrites needed in the coaxial cavity in order to reach the lower end of the band make tuning extremely easy. Both systems were thoroughly tested both at single frequencies and on a sweep and are now installed in the ring, ready for operations. Static measurements showed no high-loss effects. The Band 11 system has been fully described in a previous paper; presented here are the results of the ''bench'' tests that lead to important performance improvements

  20. Results of the 1000 Hour Rotary Microfilter Endurance Test

    International Nuclear Information System (INIS)

    Herman, D.

    2010-01-01

    During operation, a primary concern is lifetime of the mechanical seal. Leakage from main shaft mechanical seal is expected to be first indication of wear on rotary filter but will not be the ultimate failure of the filter. Initial clearance inadequate to support thermal expansion resulted in initial scarring of journal. Tolerances adjusted and no journal issues were found during 1000 hour test. Disassembly and inspection of the rotary joint seals showed no unusual wear. No leakage observed during test. Total operation time over 1500 hours. Test summary successfully demonstrated: (1) Filtration of a 'challenging' SRS simulant up to 15 wt % insoluble solids in a 5.6 M salt simulant; (2) Sludge washing; (3) In-situ acid cleaning with dilute acid; (4) Over 1000 hours of operation on new journal material; and (5) Over 1500 hours of operation on all seals. The filter out lasted: 2 air compressors, 2 power outages (one planned), 2 chillers, 1 fire, 1 electrical breaker and 1 feed pump seal.

  1. Relating results from earthworm toxicity tests to agricultural soil

    Science.gov (United States)

    Beyer, W.N.; Greig-Smith, P.W.

    1992-01-01

    The artificial soil tests of the European Economic Community and of the Organization for Economic Cooperation produce data relating earthworm mortality to pesticide concentrations in soil under laboratory conditions. To apply these results to agricultural soils it is necessary to relate these concentrations to amounts of pesticide applied per area. This paper reviews the relevant published literature and suggests a simple relation for regulatory use. Hazards to earthworms from pesticides are suggested to be greatest soon after application, when the pesticides may be concentrated in a soil layer a few millimeters thick. For estimating exposure of earthworms, however, a thicker soil layer should be considered, to account for their movement through soil. During favorable weather conditions, earthworms belonging to species appropriate to the artificial soil test have been reported to confine their activity to a layer about 5 cm. If a 5-cm layer is accepted as relevant for regulatory purposes, then an application of 1 kg/ha would be equivalent to 1-67 ppm (dry) in the artificial soil test.

  2. Radioactive Testing Results in Support of the In-Tank Precipitation Facility - Filtrate Test

    International Nuclear Information System (INIS)

    Hobbs, D.T.

    1998-01-01

    This report documents results investigating the decomposition of excess NaTPB in presence of filtrate from one of the Cycle I Demonstration tests, fulfilling a request by CST Engineering and the ITP Flow Sheet Team

  3. Caltrans accelerated pavement testing (CAL/APT) program - test results: 1993-1996

    CSIR Research Space (South Africa)

    Nokes, WA

    1997-08-01

    Full Text Available By combining the results of both the HVS and laboratory tests, interpretations of pavement performance are described and recommendations for pavement design and construction have been made to Caltrans....

  4. The Space Station Photovoltaic Panels Plasma Interaction Test Program: Test plan and results

    Science.gov (United States)

    Nahra, Henry K.; Felder, Marian C.; Sater, Bernard L.; Staskus, John V.

    1989-01-01

    The Plasma Interaction Test performed on two space station solar array panels is addressed. This includes a discussion of the test requirements, test plan, experimental set-up, and test results. It was found that parasitic current collection was insignificant (0.3 percent of the solar array delivered power). The measured arcing threshold ranged from -210 to -457 V with respect to the plasma potential. Furthermore, the dynamic response of the panels showed the panel time constant to range between 1 and 5 microsec, and the panel capacitance to be between .01 and .02 microF.

  5. The Space Station photovoltaic panels plasma interaction test program - Test plan and results

    Science.gov (United States)

    Nahra, Henry K.; Felder, Marian C.; Sater, Bernard L.; Staskus, John V.

    1990-01-01

    The plasma Interaction Test performed on two space station solar array panels is addressed. This includes a discussion of the test requirements, test plan, experimental set-up, and test results. It was found that parasitic current collection was insignificant (0.3 percent of the solar array delivered power). The measured arcing threshold ranged from -210 to -457 V with respect to the plasma potential. Furthermore, the dynamic response of the panels showed the panel time constant to range between 1 and 5 microsec, and the panel capacitance to be between .01 and .02 microF.

  6. Results from laboratory and field testing of nitrate measuring spectrophotometers

    Science.gov (United States)

    Snazelle, Teri T.

    2015-01-01

    Five ultraviolet (UV) spectrophotometer nitrate analyzers were evaluated by the U.S. Geological Survey (USGS) Hydrologic Instrumentation Facility (HIF) during a two-phase evaluation. In Phase I, the TriOS ProPs (10-millimeter (mm) path length), Hach NITRATAX plus sc (5-mm path length), Satlantic Submersible UV Nitrate Analyzer (SUNA, 10-mm path length), and S::CAN Spectro::lyser (5-mm path length) were evaluated in the HIF Water-Quality Servicing Laboratory to determine the validity of the manufacturer's technical specifications for accuracy, limit of linearity (LOL), drift, and range of operating temperature. Accuracy specifications were met in the TriOS, Hach, and SUNA. The stock calibration of the S::CAN required two offset adjustments before the analyzer met the manufacturer's accuracy specification. Instrument drift was observed only in the S::CAN and was the result of leaching from the optical path insert seals. All tested models, except for the Hach, met their specified LOL in the laboratory testing. The Hach's range was found to be approximately 18 milligrams nitrogen per liter (mg-N/L) and not the manufacturer-specified 25 mg-N/L. Measurements by all of the tested analyzers showed signs of hysteresis in the operating temperature tests. Only the SUNA measurements demonstrated excessive noise and instability in temperatures above 20 degrees Celsius (°C). The SUNA analyzer was returned to the manufacturer at the completion of the Phase II field deployment evaluation for repair and recalibration, and the performance of the sensor improved significantly.

  7. Comparison of transient PCRV model test results with analysis

    International Nuclear Information System (INIS)

    Marchertas, A.H.; Belytschko, T.B.

    1979-01-01

    Comparisons are made of transient data derived from simple models of a reactor containment vessel with analytical solutions. This effort is a part of the ongoing process of development and testing of the DYNAPCON computer code. The test results used in these comparisons were obtained from scaled models of the British sodium cooled fast breeder program. The test structure is a scaled model of a cylindrically shaped reactor containment vessel made of concrete. This concrete vessel is prestressed axially by holddown bolts spanning the top and bottom slabs along the cylindrical walls, and is also prestressed circumferentially by a number of cables wrapped around the vessel. For test purposes this containment vessel is partially filled with water, which comes in direct contact with the vessel walls. The explosive charge is immersed in the pool of water and is centrally suspended from the top of the vessel. The load history was obtained from an ICECO analysis, using the equations of state for the source and the water. A detailed check of this solution was made to assure that the derived loading did provide the correct input. The DYNAPCON code was then used for the analysis of the prestressed concrete containment model. This analysis required the simulation of prestressing and the response of the model to the applied transient load. The calculations correctly predict the magnitudes of displacements of the PCRV model. In addition, the displacement time histories obtained from the calculations reproduce the general features of the experimental records: the period elongation and amplitude increase as compared to an elastic solution, and also the absence of permanent displacement. However, the period still underestimates the experiment, while the amplitude is generally somewhat large

  8. Tc-99 Adsorption on Selected Activated Carbons - Batch Testing Results

    Energy Technology Data Exchange (ETDEWEB)

    Mattigod, Shas V.; Wellman, Dawn M.; Golovich, Elizabeth C.; Cordova, Elsa A.; Smith, Ronald M.

    2010-12-01

    CH2M HILL Plateau Remediation Company (CHPRC) is currently developing a 200-West Area groundwater pump-and-treat system as the remedial action selected under the Comprehensive Environmental Response, Compensation, and Liability Act Record of Decision for Operable Unit (OU) 200-ZP-1. This report documents the results of treatability tests Pacific Northwest National Laboratory researchers conducted to quantify the ability of selected activated carbon products (or carbons) to adsorb technetium-99 (Tc-99) from 200-West Area groundwater. The Tc-99 adsorption performance of seven activated carbons (J177601 Calgon Fitrasorb 400, J177606 Siemens AC1230AWC, J177609 Carbon Resources CR-1240-AW, J177611 General Carbon GC20X50, J177612 Norit GAC830, J177613 Norit GAC830, and J177617 Nucon LW1230) were evaluated using water from well 299-W19-36. Four of the best performing carbons (J177606 Siemens AC1230AWC, J177609 Carbon Resources CR-1240-AW, J177611 General Carbon GC20X50, and J177613 Norit GAC830) were selected for batch isotherm testing. The batch isotherm tests on four of the selected carbons indicated that under lower nitrate concentration conditions (382 mg/L), Kd values ranged from 6,000 to 20,000 mL/g. In comparison. Under higher nitrate (750 mg/L) conditions, there was a measureable decrease in Tc-99 adsorption with Kd values ranging from 3,000 to 7,000 mL/g. The adsorption data fit both the Langmuir and the Freundlich equations. Supplemental tests were conducted using the two carbons that demonstrated the highest adsorption capacity to resolve the issue of the best fit isotherm. These tests indicated that Langmuir isotherms provided the best fit for Tc-99 adsorption under low nitrate concentration conditions. At the design basis concentration of Tc 0.865 µg/L(14,700 pCi/L), the predicted Kd values from using Langmuir isotherm constants were 5,980 mL/g and 6,870 mL/g for for the two carbons. These Kd values did not meet the target Kd value of 9,000 mL/g. Tests

  9. Results of radiofrequency ablation of liver tumors: experience of 134 cases

    Directory of Open Access Journals (Sweden)

    Marcelo Augusto Fontenelle Ribeiro Junior

    2008-12-01

    Full Text Available Objective: To study radiofrequency ablation of primary and metastatic livertumors. Methods: The authors present a series of 134 cases, 63 femalesand 71 males with a mean age of 61.2 years, in whom radiofrequencyablation was used either by laparotomy or percutaneously to treat 203lesions. The group was composed of 51 cases of hepatocellular carcinoma,four cases of cholangiocarcinoma, and cases of hepatic metastases, asfollows: 64 of colorectal cancer, 6 of neuroendocrine tumors, 5 of breastcancer, 1 case of pancreas cancer, 1 of kidney cancer, 1 of endometrialcancer and 1 of leiomyosarcoma. Results: Procedure-associatedmorbidity/mortality was 24.8 and 3.7%, respectively. Recurrence wasobserved in 12.7% within a mean time of 10.5 months. Conclusions:Radiofrequency ablation is a safe procedure and can be used in patientswith impaired hepatic function. For metastatic diseases, it does notreplace surgery but it can be associated with other procedures, such assurgery and transarterial chemoembolization, or after recurrence, leadingto greater probability of remaining disease-free.

  10. First irradiation test results of the ALICE SAMPA ASIC

    CERN Document Server

    Mahmood, Sohail Musa; Winje, Fredrik Lindseth; Velure, Arild

    2018-01-01

    With the continuous scaling of the CMOS technology, the CMOS circuits are considered to be more tolerant to Single event Latchup (SEL) effects due to the reduction in the supply voltages. This paper reports the results from SEL testing performed on the first two prototypes for the new readout ASIC (SAMPA). During RUN 3/RUN 4 at the Large Hadron Collider (LHC), the SAMPA chip will be used for the upgrade of read-out front end electronics of the ALICE (A Large Ion Collider Experiment) Time Projection Chamber (TPC) and Muon Chambers (MCH). The first prototype MPW1 and the second prototype V2 of the SAMPA chip were delivered in 2015 and 2016, respectively. The results are summarized from two different proton beam irradiation campaigns, conducted for SAMPA MPW1 and V2 prototypes at The Svedberg Laboratory (TSL) in Uppsala, and the Center of Advanced Radiation Technology (KVI) in Groningen, respectively.

  11. Assessment of the (/sup 14/C) aminopyrine breath test in liver disease

    Energy Technology Data Exchange (ETDEWEB)

    Galizzi, J; Long, R G; Billing, B H; Sherlock, S [Royal Free Hospital, London (UK)

    1978-01-01

    Different methods of performing the (/sup 14/C) aminopyrine breath test have been assessed. A tracer dose of 2 ..mu..Ci without a loading dose and with a single breath collection at two hours was the method selected, since it gave the best discrimination between patients with hepatocellular diseases and normal subjects (5.2 +- 0.2%, mean - SEM). Reduced values occurred in patients with chronic active hepatitis (with and without cirrhosis) (1.5 +- 0.2%), alcoholic cirrhosis (1.7 +- 0.4%) and hepatitis (2.5 +- 0.3%), and late primary biliary cirrhosis suggesting defective microsomal function with respect to demethylation. Normal results were common in early primary biliary cirrhosis. Two weeks of prednisolone therapy caused some improvement in the breath test in nine of ten patients with chronic active hepatitis. It is concluded that the (/sup 14/C) aminopyrine breath test is a simple test for detecting hepatocellular dysfunction, but has no obvious diagnostic advantage over the determination of serum aspartate transaminase and two hour post-prandial bile-acids.

  12. Test results for fuel cell operation on anaerobic digester gas

    Science.gov (United States)

    Spiegel, R. J.; Preston, J. L.

    EPA, in conjunction with ONSI, embarked on a project to define, design, test, and assess a fuel cell energy recovery system for application at anaerobic digester waste water (sewage) treatment plants. Anaerobic digester gas (ADG) is produced at these plants during the process of treating sewage anaerobically to reduce solids. ADG is primarily comprised of methane (57-66%), carbon dioxide (33-39%), nitrogen (1-10%), and a small amount of oxygen (sulfur-bearing compounds (principally hydrogen sulfide) and halogen compounds (chlorides). The project has addressed two major issues: development of a cleanup system to remove fuel cell contaminants from the gas and testing/assessing of a modified ONSI PC25 C fuel cell power plant operating on the cleaned, but dilute, ADG. Results to date demonstrate that the ADG fuel cell power plant can, depending on the energy content of the gas, produce electrical output levels close to full power (200 kW) with measured air emissions comparable to those obtained by a natural gas fuel cell. The cleanup system results show that the hydrogen sulfide levels are reduced to below 10 ppbv and halides to approximately 30 ppbv.

  13. Test results for cables used in nuclear power plants by a new environmental testing method

    Energy Technology Data Exchange (ETDEWEB)

    Handa, Katsue; Fujimura, Shun-ichi; Hayashi, Toshiyasu; Takano, Keiji; Oya, Shingo

    1982-12-01

    In the nuclear power plants using PWRs or BWRs in Japan, environmental tests are provided, in which simulated LOCA conditions are considered so as to conform with Japanese conditions, and many cables which passed these tests are presently employed. Lately, the new environmental testing, in which a credible accident called MSLB (main steam line breakage) is taken into account, is investigated in PWR nuclear power plants, besides LOCA. This paper reports on the results of evaluating some PWR cables for this new environmental testing conditions. The several cables tested were selected out of PH cables (fire-retardant, ethylene propylene rubber insulated, chlorosulfonated polyethylene sheathed cables) as the cables for safety protecting circuits and to be used in containment vessels where the cables are to be exposed to severe environmental test conditions of 2 x 10/sup 8/ Rad ..gamma..-irradiation and simulated LOCA. All these cables have been accepted after the vertical tray burning test provided in the IEEE Standard 383. The new testing was carried out by sequentially applying thermal deterioration, ..gamma..-irradiation, and the exposure to steam (twice 300 s exposures to 190 deg C superheated steam). After completing each step, tensile strength, elongation, insulation resistance and breakdown voltage were measured, respectively. Every cable tested showed satisfactory breakdown voltage after the exposure to steam, thus it was decided to be acceptable. In future, it is required to investigate the influence of the rate of temperature rise on the cable to be tested in MSLB simulation.

  14. Test results for cables used in nuclear power plants by a new environmental testing method

    International Nuclear Information System (INIS)

    Handa, Katsue; Fujimura, Shun-ichi; Hayashi, Toshiyasu; Takano, Keiji; Oya, Shingo

    1982-01-01

    In the nuclear power plants using PWRs or BWRs in Japan, environmental tests are provided, in which simulated LOCA conditions are considered so as to conform with Japanese conditions, and many cables which passed these tests are presently employed. Lately, the new environmental testing, in which a credible accident called MSLB (main steam line breakage) is taken into account, is investigated in PWR nuclear power plants, besides LOCA. This paper reports on the results of evaluating some PWR cables for this new environmental testing conditions. The several cables tested were selected out of PH cables (fire-retardant, ethylene propylene rubber insulated, chlorosulfonated polyethylene sheathed cables) as the cables for safety protecting circuits and to be used in containment vessels where the cables are to be exposed to severe environmental test conditions of 2 x 10 8 Rad γ-irradiation and simulated LOCA. All these cables have been accepted after the vertical tray burning test provided in the IEEE Standard 383. The new testing was carried out by sequentially applying thermal deterioration, γ-irradiation, and the exposure to steam (twice 300 s exposures to 190 deg C superheated steam). After completing each step, tensile strength, elongation, insulation resistance and breakdown voltage were measured, respectively. Every cable tested showed satisfactory breakdown voltage after the exposure to steam, thus it was decided to be acceptable. In future, it is required to investigate the influence of the rate of temperature rise on the cable to be tested in MSLB simulation. (Wakatsuki, Y.)

  15. Aerodynamic and Acoustic Flight Test Results and Results for the Stratospheric Observatory for Infrared Astronomy

    Science.gov (United States)

    Cumming, Stephen B.; Smith, Mark S.; Cliatt, Larry J.; Frederick, Michael A.

    2014-01-01

    As part of the Stratospheric Observatory for Infrared Astronomy program, a 747SP airplane was modified to carry a 2.5-m telescope in the aft section of the fuselage. The resulting airborne observatory allows for observations above 99 percent of the water vapor in the atmosphere. The open cavity created by the modifications had the potential to significantly affect the airplane in the areas of aerodynamics and acoustics. Several series of flight tests were conducted to clear the operating envelope of the airplane for astronomical observations, planned to be performed between the altitudes of 35,000 ft and 45,000 ft. The flight tests were successfully completed. Cavity acoustics were below design limits, and the overall acoustic characteristics of the cavity were better than expected. The modification did have some effects on the stability and control of the airplane, but these effects were not significant. Airplane air data systems were not affected by the modifications. This paper describes the methods used to examine the aerodynamics and acoustic data from the flight tests and provides a discussion of the flight-test results in the areas of cavity acoustics, stability and control, and air data.

  16. Summary of ROSA-4 LSTF first phase test program and station blackout (TMLB) test results

    International Nuclear Information System (INIS)

    Tasaka, K.; Kukita, Y.; Anoda, Y.

    1990-01-01

    This paper summarizes major test results obtained at the ROSA-4 Large Scale Test Facility (LSTF) during the first phase of the test program. The results from a station blackout (TMLB) test conducted at the end of the first-phase program are described in some detail. The LSTF is an integral test facility being operated by the Japan Atomic Energy Research Institute for simulation of pressurized water reactor (PWR) thermal-hydraulic responses during small-break loss-of-coolant accidents (SBLOCAs) and operational/abnormal transients. It is a 1/48 volumetrically scaled, full-height, full-pressure simulator of a Westinghouse-type 4-loop PWR. The facility includes two symmetric primary loops each one containing an active inverted-U tube steam generator and an active reactor coolant pump. The loop horizontal legs are sized to conserve the scaled (1/24) volumes as well as the length to the square root of the diameter ratio in order to simulate the two-phase flow regime transitions. The primary objective of the LSTF first-phase program was to define the fundamental PWR thermal-hydraulic responses during SBLOCAs and transients. Most of the tests were conducted with simulated component/operator failures, including unavailability of the high pressure injection system and auxiliary feedwater system, as well as operator failure to take corrective actions. The forty-two first phase tests included twenty-nine SBLOCA tests conducted mainly for cold leg breaks, three abnormal transient tests and ten natural circulation tests. Attempts were made in several of the SBLOCA tests to simulate the plant recovery procedures as well as candidate accident management measures for prevention of high-pressure core melt situation. The natural circulation tests simulated the single-phase and two-phase natural circulation as well as reflux condensation behavior in the primary loops in steady or quasi-steady states

  17. Mutagenicity in drug development: interpretation and significance of test results.

    Science.gov (United States)

    Clive, D

    1985-03-01

    The use of mutagenicity data has been proposed and widely accepted as a relatively fast and inexpensive means of predicting long-term risk to man (i.e., cancer in somatic cells, heritable mutations in germ cells). This view is based on the universal nature of the genetic material, the somatic mutation model of carcinogenesis, and a number of studies showing correlations between mutagenicity and carcinogenicity. An uncritical acceptance of this approach by some regulatory and industrial concerns is over-conservative, naive, and scientifically unjustifiable on a number of grounds: Human cancers are largely life-style related (e.g., cigarettes, diet, tanning). Mutagens (both natural and man-made) are far more prevalent in the environment than was originally assumed (e.g., the natural bases and nucleosides, protein pyrolysates, fluorescent lights, typewriter ribbon, red wine, diesel fuel exhausts, viruses, our own leukocytes). "False-positive" (relative to carcinogenicity) and "false-negative" mutagenicity results occur, often with rational explanations (e.g., high threshold, inappropriate metabolism, inadequate genetic endpoint), and thereby confound any straightforward interpretation of mutagenicity test results. Test battery composition affects both the proper identification of mutagens and, in many instances, the ability to make preliminary risk assessments. In vitro mutagenicity assays ignore whole animal protective mechanisms, may provide unphysiological metabolism, and may be either too sensitive (e.g., testing at orders-of-magnitude higher doses than can be ingested) or not sensitive enough (e.g., short-term treatments inadequately model chronic exposure in bioassay). Bacterial systems, particularly the Ames assay, cannot in principle detect chromosomal events which are involved in both carcinogenesis and germ line mutations in man. Some compounds induce only chromosomal events and little or no detectable single-gene events (e.g., acyclovir, caffeine

  18. School results and access test results as indicators of first-year performance at university

    Directory of Open Access Journals (Sweden)

    A Bothma

    2004-06-01

    Full Text Available The goals set by the National Plan for Higher Education, the fact that many schools are still severely disadvantaged as well as far-reaching changes in the school system demand that South African universities urgently reconsider their admission procedures. Redesigning admission procedures calls for a thorough understanding of the interrelationships between school marks, results in existing access tests and first-year university performance. These interrelationships were statistically investigated in the case of the 1999, 2000 and 2001 intake groups, who were compelled to write access tests before being admitted to Stellenbosch University. The results of this investigation confirm an alarming degree of unpreparedness among many prospective students regarding what is expected of them at university. This is aggravated by school marks creating a totally unrealistic expectation of performance in the first year at university. It is emphasised that schools and authorities dealing with admission of prospective students at universities should be cognisant of the findings reported here. Furthermore, the statistical analyses demonstrate several novel techniques for investigating the interrelationship between school marks, access test results and university performance.

  19. Results of industrial tests of carbonate additive to fuel oil

    Science.gov (United States)

    Zvereva, E. R.; Dmitriev, A. V.; Shageev, M. F.; Akhmetvalieva, G. R.

    2017-08-01

    Fuel oil plays an important role in the energy balance of our country. The quality of fuel oil significantly affects the conditions of its transport, storage, and combustion; release of contaminants to atmosphere; and the operation of main and auxiliary facilities of HPPs. According to the Energy Strategy of Russia for the Period until 2030, the oil-refining ratio gradually increases; as a result, the fraction of straight-run fuel oil in heavy fuel oils consistently decreases, which leads to the worsening of performance characteristics of fuel oil. Consequently, the problem of the increase in the quality of residual fuel oil is quite topical. In this paper, it is suggested to treat fuel oil by additives during its combustion, which would provide the improvement of ecological and economic indicators of oil-fired HPPs. Advantages of this method include simplicity of implementation, low energy and capital expenses, and the possibility to use production waste as additives. In the paper, the results are presented of industrial tests of the combustion of fuel oil with the additive of dewatered carbonate sludge, which is formed during coagulation and lime treatment of environmental waters on HPPs. The design of a volume delivery device is developed for the steady additive input to the boiler air duct. The values are given for the main parameters of the condition of a TGM-84B boiler plant. The mechanism of action of dewatered carbonate sludge on sulfur oxides, which are formed during fuel oil combustion, is considered. Results of industrial tests indicate the decrease in the mass fraction of discharged sulfur oxides by 36.5%. Evaluation of the prevented damage from sulfur oxide discharged into atmospheric air shows that the combustion of the fuel oil of 100 brand using carbonate sludge as an additive (0.1 wt %) saves nearly 6 million rubles a year during environmental actions at the consumption of fuel oil of 138240 t/year.

  20. Test Results and Comparison of Triaxial Strength Testing of Waste Isolation Pilot Plant Clean Salt

    Energy Technology Data Exchange (ETDEWEB)

    Buchholz, Stuart A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-12-01

    This memorandum documents laboratory thermomechanical triaxial strength testing of Waste Isolation Pilot Plant (WIPP) clean salt. The limited study completed independent, adjunct laboratory tests in the United States to assist in validating similar testing results being provided by the German facilities. The testing protocol consisted of completing confined triaxial, constant strain rate strength tests of intact WIPP clean salt at temperatures of 25°C and 100°C and at multiple confining pressures. The stratigraphy at WIPP also includes salt that has been labeled “argillaceous.” The much larger test matrix conducted in Germany included both the so-called clean and argillaceous salts. When combined, the total database of laboratory results will be used to develop input parameters for models, assess adequacy of existing models, and predict material behavior. These laboratory studies are also consistent with the goals of the international salt repository research program. The goal of this study was to complete a subset of a test matrix on clean salt from the WIPP undertaken by German research groups. The work was performed at RESPEC in Rapid City, South Dakota. A rigorous Quality Assurance protocol was applied, such that corroboration provides the potential of qualifying all of the test data gathered by German research groups.