WorldWideScience

Sample records for link establishment ale

  1. Measuring Extinction with ALE

    Science.gov (United States)

    Zimmer, Peter C.; McGraw, J. T.; Gimmestad, G. G.; Roberts, D.; Stewart, J.; Smith, J.; Fitch, J.

    2007-12-01

    ALE (Astronomical LIDAR for Extinction) is deployed at the University of New Mexico's (UNM) Campus Observatory in Albuquerque, NM. It has begun a year-long testing phase prior deployment at McDonald Observatory in support of the CCD/Transit Instrument II (CTI-II). ALE is designed to produce a high-precision measurement of atmospheric absorption and scattering above the observatory site every ten minutes of every moderately clear night. LIDAR (LIght Detection And Ranging) is the VIS/UV/IR analog of radar, using a laser, telescope and time-gated photodetector instead of a radio transmitter, dish and receiver. In the case of ALE -- an elastic backscatter LIDAR -- 20ns-long, eye-safe laser pulses are launched 2500 times per second from a 0.32m transmitting telescope co-mounted with a 50mm short-range receiver on an alt-az mounted 0.67m long-range receiver. Photons from the laser pulse are scattered and absorbed as the pulse propagates through the atmosphere, a portion of which are scattered into the field of view of the short- and long-range receiver telescopes and detected by a photomultiplier. The properties of a given volume of atmosphere along the LIDAR path are inferred from both the altitude-resolved backscatter signal as well as the attenuation of backscatter signal from altitudes above it. We present ALE profiles from the commissioning phase and demonstrate some of the astronomically interesting atmospheric information that can be gleaned from these data, including, but not limited to, total line-of-sight extinction. This project is funded by NSF Grant 0421087.

  2. An Invariant-Preserving ALE Method for Solids under Extreme Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Sambasivan, Shiv Kumar [Los Alamos National Laboratory; Christon, Mark A [Los Alamos National Laboratory

    2012-07-17

    We are proposing a fundamentally new approach to ALE methods for solids undergoing large deformation due to extreme loading conditions. Our approach is based on a physically-motivated and mathematically rigorous construction of the underlying Lagrangian method, vector/tensor reconstruction, remapping, and interface reconstruction. It is transformational because it deviates dramatically from traditionally accepted ALE methods and provides the following set of unique attributes: (1) a three-dimensional, finite volume, cell-centered ALE framework with advanced hypo-/hyper-elasto-plastic constitutive theories for solids; (2) a new physically and mathematically consistent reconstruction method for vector/tensor fields; (3) advanced invariant-preserving remapping algorithm for vector/tensor quantities; (4) moment-of-fluid (MoF) interface reconstruction technique for multi-material problems with solids undergoing large deformations. This work brings together many new concepts, that in combination with emergent cell-centered Lagrangian hydrodynamics methods will produce a cutting-edge ALE capability and define a new state-of-the-art. Many ideas in this work are new, completely unexplored, and hence high risk. The proposed research and the resulting algorithms will be of immediate use in Eulerian, Lagrangian and ALE codes under the ASC program at the lab. In addition, the research on invariant preserving reconstruction/remap of tensor quantities is of direct interest to ongoing CASL and climate modeling efforts at LANL. The application space impacted by this work includes Inertial Confinement Fusion (ICF), Z-pinch, munition-target interactions, geological impact dynamics, shock processing of powders and shaped charges. The ALE framework will also provide a suitable test-bed for rapid development and assessment of hypo-/hyper-elasto-plastic constitutive theories. Today, there are no invariant-preserving ALE algorithms for treating solids with large deformations. Therefore

  3. Deposition of HgTe by electrochemical atomic layer epitaxy (EC-ALE)

    CSIR Research Space (South Africa)

    Venkatasamy, V

    2006-04-01

    Full Text Available This paper describes the first instance of HgTe growth by electrochemical atomic layer epitaxy (EC-ALE). EC-ALE is the electrochemical analog of atomic layer epitaxy (ALE) and atomic layer deposition (ALD), all of which are based on the growth...

  4. An AMR capable finite element diffusion solver for ALE hydrocodes [An AMR capable diffusion solver for ALE-AMR

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, A. C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bailey, D. S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kaiser, T. B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Eder, D. C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gunney, B. T. N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Masters, N. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Koniges, A. E. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Anderson, R. W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-02-01

    Here, we present a novel method for the solution of the diffusion equation on a composite AMR mesh. This approach is suitable for including diffusion based physics modules to hydrocodes that support ALE and AMR capabilities. To illustrate, we proffer our implementations of diffusion based radiation transport and heat conduction in a hydrocode called ALE-AMR. Numerical experiments conducted with the diffusion solver and associated physics packages yield 2nd order convergence in the L2 norm.

  5. ALE3D: An Arbitrary Lagrangian-Eulerian Multi-Physics Code

    Energy Technology Data Exchange (ETDEWEB)

    Noble, Charles R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Anderson, Andrew T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Barton, Nathan R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bramwell, Jamie A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Capps, Arlie [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chang, Michael H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chou, Jin J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dawson, David M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Diana, Emily R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dunn, Timothy A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Faux, Douglas R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fisher, Aaron C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Greene, Patrick T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinz, Ines [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kanarska, Yuliya [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Khairallah, Saad A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Liu, Benjamin T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Margraf, Jon D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Nichols, Albert L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Nourgaliev, Robert N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Puso, Michael A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reus, James F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Robinson, Peter B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Shestakov, Alek I. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Solberg, Jerome M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Taller, Daniel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Tsuji, Paul H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); White, Christopher A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); White, Jeremy L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-05-23

    ALE3D is a multi-physics numerical simulation software tool utilizing arbitrary-Lagrangian- Eulerian (ALE) techniques. The code is written to address both two-dimensional (2D plane and axisymmetric) and three-dimensional (3D) physics and engineering problems using a hybrid finite element and finite volume formulation to model fluid and elastic-plastic response of materials on an unstructured grid. As shown in Figure 1, ALE3D is a single code that integrates many physical phenomena.

  6. The LOCAL attack: Cryptanalysis of the authenticated encryption scheme ALE

    DEFF Research Database (Denmark)

    Khovratovich, Dmitry; Rechberger, Christian

    2014-01-01

    We show how to produce a forged (ciphertext, tag) pair for the scheme ALE with data and time complexity of 2102 ALE encryptions of short messages and the same number of authentication attempts. We use a differential attack based on a local collision, which exploits the availability of extracted...

  7. Time-discrete higher order ALE formulations: a priori error analysis

    KAUST Repository

    Bonito, Andrea

    2013-03-16

    We derive optimal a priori error estimates for discontinuous Galerkin (dG) time discrete schemes of any order applied to an advection-diffusion model defined on moving domains and written in the Arbitrary Lagrangian Eulerian (ALE) framework. Our estimates hold without any restrictions on the time steps for dG with exact integration or Reynolds\\' quadrature. They involve a mild restriction on the time steps for the practical Runge-Kutta-Radau methods of any order. The key ingredients are the stability results shown earlier in Bonito et al. (Time-discrete higher order ALE formulations: stability, 2013) along with a novel ALE projection. Numerical experiments illustrate and complement our theoretical results. © 2013 Springer-Verlag Berlin Heidelberg.

  8. Time-Discrete Higher-Order ALE Formulations: Stability

    KAUST Repository

    Bonito, Andrea

    2013-01-01

    Arbitrary Lagrangian Eulerian (ALE) formulations deal with PDEs on deformable domains upon extending the domain velocity from the boundary into the bulk with the purpose of keeping mesh regularity. This arbitrary extension has no effect on the stability of the PDE but may influence that of a discrete scheme. We examine this critical issue for higher-order time stepping without space discretization. We propose time-discrete discontinuous Galerkin (dG) numerical schemes of any order for a time-dependent advection-diffusion-model problem in moving domains, and study their stability properties. The analysis hinges on the validity of the Reynold\\'s identity for dG. Exploiting the variational structure and assuming exact integration, we prove that our conservative and nonconservative dG schemes are equivalent and unconditionally stable. The same results remain true for piecewise polynomial ALE maps of any degree and suitable quadrature that guarantees the validity of the Reynold\\'s identity. This approach generalizes the so-called geometric conservation law to higher-order methods. We also prove that simpler Runge-Kutta-Radau methods of any order are conditionally stable, that is, subject to a mild ALE constraint on the time steps. Numerical experiments corroborate and complement our theoretical results. © 2013 Society for Industrial and Applied Mathematics.

  9. History of the pharmacies in the town of Aleşd, Bihor county.

    Science.gov (United States)

    Paşca, Manuela Bianca; Gîtea, Daniela; Moisa, Corina

    2013-01-01

    In 1848 pharmacist Horváth Mihály established the first pharmacy in Aleşd, called Speranţa (Remény). Following the brief history of this pharmacy we will notice that in 1874 the pharmacy comes into the possession of Kocsiss József. In 1906 the personal rights of the pharmacy are transcribed to Kocsiss Béla, and since 1938 the his son, Kocsiss Dezső, pharmacist, became the new owner. In 1949 the pharmacy was nationalized and became the property of the Pharmaceutical Office Oradea, the pharmacy got the name Farmacia nr. 22 of Aleşd, and continued its activity throughout the whole communist period. Starting with the year 1991 it entered into private system as Angefarm, as the property of Mermeze Gheorghe, pharmacist, and from 2003 until now works under the name Vitalogy 3, as the property of Ghitea Sorin. A second pharmacy, Sfântul Anton was founded in 1937 by pharmacist Herceg Dobreanu Atena, which however had no continuity during the communist period.

  10. Affective mapping: An activation likelihood estimation (ALE) meta-analysis.

    Science.gov (United States)

    Kirby, Lauren A J; Robinson, Jennifer L

    2017-11-01

    Functional neuroimaging has the spatial resolution to explain the neural basis of emotions. Activation likelihood estimation (ALE), as opposed to traditional qualitative meta-analysis, quantifies convergence of activation across studies within affective categories. Others have used ALE to investigate a broad range of emotions, but without the convenience of the BrainMap database. We used the BrainMap database and analysis resources to run separate meta-analyses on coordinates reported for anger, anxiety, disgust, fear, happiness, humor, and sadness. Resultant ALE maps were compared to determine areas of convergence between emotions, as well as to identify affect-specific networks. Five out of the seven emotions demonstrated consistent activation within the amygdala, whereas all emotions consistently activated the right inferior frontal gyrus, which has been implicated as an integration hub for affective and cognitive processes. These data provide the framework for models of affect-specific networks, as well as emotional processing hubs, which can be used for future studies of functional or effective connectivity. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Simulating Small-Scale Experiments of In-Tunnel Airblast Using STUN and ALE3D

    Energy Technology Data Exchange (ETDEWEB)

    Neuscamman, Stephanie [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, Lewis [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Schebler, Gregory [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McMichael, Larry [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glascoe, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-09-12

    This report details continuing validation efforts for the Sphere and Tunnel (STUN) and ALE3D codes. STUN has been validated previously for blast propagation through tunnels using several sets of experimental data with varying charge sizes and tunnel configurations, including the MARVEL nuclear driven shock tube experiment (Glenn, 2001). The DHS-funded STUNTool version is compared to experimental data and the LLNL ALE3D hydrocode. In this particular study, we compare the performance of the STUN and ALE3D codes in modeling an in-tunnel airblast to experimental results obtained by Lunderman and Ohrt in a series of small-scale high explosive experiments (1997).

  12. Coastal Improvements for Tide Models: The Impact of ALES Retracker

    Directory of Open Access Journals (Sweden)

    Gaia Piccioni

    2018-05-01

    Full Text Available Since the launch of the first altimetry satellites, ocean tide models have been improved dramatically for deep and shallow waters. However, issues are still found for areas of great interest for climate change investigations: the coastal regions. The purpose of this study is to analyze the influence of the ALES coastal retracker on tide modeling in these regions with respect to a standard open ocean retracker. The approach used to compute the tidal constituents is an updated and along-track version of the Empirical Ocean Tide model developed at DGFI-TUM. The major constituents are derived from a least-square harmonic analysis of sea level residuals based on the FES2014 tide model. The results obtained with ALES are compared with the ones estimated with the standard product. A lower fitting error is found for the ALES solution, especially for distances closer than 20 km from the coast. In comparison with in situ data, the root mean squared error computed with ALES can reach an improvement larger than 2 cm at single locations, with an average impact of over 10% for tidal constituents K 2 , O 1 , and P 1 . For Q 1 , the improvement is over 25%. It was observed that improvements to the root-sum squares are larger for distances closer than 10 km to the coast, independently on the sea state. Finally, the performance of the solutions changes according to the satellite’s flight direction: for tracks approaching land from open ocean root mean square differences larger than 1 cm are found in comparison to tracks going from land to ocean.

  13. Supersymmetric 3-branes on smooth ALE manifolds with flux

    International Nuclear Information System (INIS)

    Bertolini, M.; Campos, V.L.; Ferretti, G.; Fre, P.; Salomonson, P.; Trigiante, M.

    2001-01-01

    We construct a new family of classical BPS solutions of type IIB supergravity describing 3-branes transverse to a 6-dimensional space with topology R 2 xALE. They are characterized by a non-trivial flux of the supergravity 2-forms through the homology 2-cycles of a generic smooth ALE manifold. Our solutions have two Killing spinors and thus preserve N=2 supersymmetry. They are expressed in terms of a quasi harmonic function H (the 'warp factor'), whose properties we study in the case of the simplest ALE, namely the Eguchi-Hanson manifold. The equation for H is identified as an instance of the confluent Heun equation. We write explicit power series solutions and solve the recurrence relation for the coefficients, discussing also the relevant asymptotic expansions. While, as in all such N=2 solutions, supergravity breaks down near the brane, the smoothing out of the vacuum geometry has the effect that the warp factor is regular in a region near the cycle. We interpret the behavior of the warp factor as describing a three-brane charge 'smeared' over the cycle and consider the asymptotic form of the geometry in that region, showing that conformal invariance is broken even when the complex type IIB 3-form field strength is assumed to vanish. We conclude with a discussion of the basic features of the gauge theory dual

  14. Magneto-Hydrodynamic Simulations of a Magnetic Flux Compression Generator Using ALE3D

    Science.gov (United States)

    2017-07-01

    3 Fig. 3 Half- plane view of the geometry used in ALE3D simulation showing the materials...to LLNL’s SESAME data.8 Fig. 3 Half- plane view of the geometry used in ALE3D simulation showing the materials There are 2 broad approaches to...of mesh can be time- consuming . Since MFCGs have a cylindrical geometry, a high-resolution mesh is not required; one can use a conformal mesh and

  15. Time-discrete higher order ALE formulations: a priori error analysis

    KAUST Repository

    Bonito, Andrea; Kyza, Irene; Nochetto, Ricardo H.

    2013-01-01

    We derive optimal a priori error estimates for discontinuous Galerkin (dG) time discrete schemes of any order applied to an advection-diffusion model defined on moving domains and written in the Arbitrary Lagrangian Eulerian (ALE) framework. Our

  16. Viñales Taxonomic Characterization and trophic groups of two communities of birds associated to semideciduos forests and vegetation of Pine-oak of the paths «Marvels of Viñales» and «Valley Ancón» in Viñales National Park

    Directory of Open Access Journals (Sweden)

    Miguel Cué Rivero

    2015-06-01

    Full Text Available The present work was carried out in the months of February to April 2009 in the semideciduos forest «Marvels of Viñales» and the formation pine-encino of the «Valley Ancón» of the Viñales National Park and it pursued as main objective to characterize the taxonomic composition and tropic groups tof two communities of birds associated to semideciduos forest and pine oak vegetation from both -. The method of circular parcels of fixed radio was used in 30 points of counts separated to 150 m one of another. There were detected a total of 44 species of birds (in the semideciduo and 42 in pine-oak contained in 9 orders and 18 families. They registered 23 trophic groups with prevalence of Insectivorous. The communities of birds of the formation of semideciduo forest of the path «Marvels of Viñales» and of the forest of pine oak of «Valley Ancón» presented differences in its taxonomic composition The communities of birds of both vegetable formations showed differences as for their trophiccomposition but so much in one as in other majority of birds consumers of insects and grains was observed.

  17. Odpověď Pavla Janouška Aleši Hamanovi

    Czech Academy of Sciences Publication Activity Database

    Janoušek, Pavel

    2014-01-01

    Roč. 25, č. 2 (2014), s. 18 ISSN 0862-657X Institutional support: RVO:68378068 Keywords : Czech literature * socially engaged art * Haman, Aleš * polemics Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Link establishment criterion and topology optimization for hybrid GPS satellite communications with laser crosslinks

    Science.gov (United States)

    Li, Lun; Wei, Sixiao; Tian, Xin; Hsieh, Li-Tse; Chen, Zhijiang; Pham, Khanh; Lyke, James; Chen, Genshe

    2018-05-01

    In the current global positioning system (GPS), the reliability of information transmissions can be enhanced with the aid of inter-satellite links (ISLs) or crosslinks between satellites. Instead of only using conventional radio frequency (RF) crosslinks, the laser crosslinks provide an option to significantly increase the data throughput. The connectivity and robustness of ISL are needed for analysis, especially for GPS constellations with laser crosslinks. In this paper, we first propose a hybrid GPS communication architecture in which uplinks and downlinks are established via RF signals and crosslinks are established via laser links. Then, we design an optical crosslink assignment criteria considering the practical optical communication factors such as optical line- of-sight (LOS) range, link distance, and angular velocity, etc. After that, to further improve the rationality of establishing crosslinks, a topology control algorithm is formulated to optimize GPS crosslink networks at both physical and network layers. The RF transmission features for uplink and downlink and optical transmission features for crosslinks are taken into account as constraints for the optimization problem. Finally, the proposed link establishment criteria are implemented for GPS communication with optical crosslinks. The designs of this paper provide a potential crosslink establishment and topology control algorithm for the next generation GPS.

  19. Compresión de señales electroencefalográficas epilépticas y normales

    Directory of Open Access Journals (Sweden)

    Fernando Cruz Roldán

    2012-02-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Las señales electroencefalográficas son empleadas en el estudio de varias enfermedades, pero generan volúmenes de datos que dificultan su procesamiento. La compresión de estas señales permite disminuir el volumen de datos adquiridos, facilitando su manipulación.   La epilepsia es una de las más comunes de esas enfermedades y las señales que registran este tipo de anomalía difieren algo de las señales electroencefalográficas comunes. En este trabajo se analiza el comportamiento de la compresión de señales que contienen episodios epilépticos, comparado con otras que no lo contienen. Se establecen un grupo de parámetros de calidad y de compresión para establecer la comparación. Como resultado se obtiene una mejor calidad y una mayor compresión cuando la señal contiene episodios epilépticos. Este resultado se asocia a la sincronización que ocurre en estos casos y la correspondiente contracción de las bandas de frecuencia con mayor contenido de información relevante.

  20. A coupling of empirical explosive blast loads to ALE air domains in LS-DYNA (registered)

    International Nuclear Information System (INIS)

    Slavik, Todd P

    2010-01-01

    A coupling method recently implemented in LS-DYNA (registered) allows empirical explosive blast loads to be applied to air domains treated with the multi-material arbitrary Lagrangian-Eulerian (ALE) formulation. Previously, when simulating structures subjected to blast loads, two methods of analysis were available: a purely Lagrangian approach or one involving the ALE and Lagrangian formulations coupled with a fluid-structure interaction (FSI) algorithm. In the former, air blast pressure is computed with empirical equations and directly applied to Lagrangian elements of the structure. In the latter approach, the explosive as well as the air are explicitly modeled and the blast wave propagating through the ALE air domain impinges on the Lagrangian structure through FSI. Since the purely Lagrangian approach avoids modeling the air between the explosive and structure, a significant computational cost savings can be realized - especially so when large standoff distances are considered. The shortcoming of the empirical blast equations is their inability to account for focusing or shadowing of the blast waves due to their interaction with structures which may intervene between the explosive and primary structure of interest. The new method presented here obviates modeling the explosive and air leading up the structure. Instead, only the air immediately surrounding the Lagrangian structures need be modeled with ALE, while effects of the far-field blast are applied to the outer face of that ALE air domain with the empirical blast equations; thus, focusing and shadowing effects can be accommodated yet computational costs are kept to a minimum. Comparison of the efficiency and accuracy of this new method with other approaches shows that the ability of LS-DYNA (registered) to model a variety of new blast scenarios has been greatly extended.

  1. Establishing Interoperability of a Blog Archive through Linked Open Data

    DEFF Research Database (Denmark)

    Kalb, Hendrik; Lazaridou, Paraskevi; Trier, Matthias

    2013-01-01

    on archived data. However, interoperability among BlogForever archives, as well as with other digital libraries, is necessary in order to avoid silos of data. In this paper, we reveal some of our efforts to establish interoperability through the application of Linked Open data....

  2. La Malakoplakie Rétropéritonéale Pseudotumorale

    African Journals Online (AJOL)

    mn

    gine tuberculeuse et le syndrome de masse rétropéritonéale, faisant discuter en première intention un sarcome des parties molles ou un lymphome5. Microscopiquement, le gra- nulome malakoplasique est caractérisé par la présence des cellules de Van Hansemann4. Ces cellules sont des histiocytes à larges cy-.

  3. Microbial diversity and metabolite composition of Belgian red-brown acidic ales.

    Science.gov (United States)

    Snauwaert, Isabel; Roels, Sanne P; Van Nieuwerburg, Filip; Van Landschoot, Anita; De Vuyst, Luc; Vandamme, Peter

    2016-03-16

    Belgian red-brown acidic ales are sour and alcoholic fermented beers, which are produced by mixed-culture fermentation and blending. The brews are aged in oak barrels for about two years, after which mature beer is blended with young, non-aged beer to obtain the end-products. The present study evaluated the microbial community diversity of Belgian red-brown acidic ales at the end of the maturation phase of three subsequent brews of three different breweries. The microbial diversity was compared with the metabolite composition of the brews at the end of the maturation phase. Therefore, mature brew samples were subjected to 454 pyrosequencing of the 16S rRNA gene (bacteria) and the internal transcribed spacer region (yeasts) and a broad range of metabolites was quantified. The most important microbial species present in the Belgian red-brown acidic ales investigated were Pediococcus damnosus, Dekkera bruxellensis, and Acetobacter pasteurianus. In addition, this culture-independent analysis revealed operational taxonomic units that were assigned to an unclassified fungal community member, Candida, and Lactobacillus. The main metabolites present in the brew samples were L-lactic acid, D-lactic acid, and ethanol, whereas acetic acid was produced in lower quantities. The most prevailing aroma compounds were ethyl acetate, isoamyl acetate, ethyl hexanoate, and ethyl octanoate, which might be of impact on the aroma of the end-products. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Analysis of Thermo-Mechanical Distortions in Sliding Components : An ALE Approach

    NARCIS (Netherlands)

    Owczarek, P.; Geijselaers, H.J.M.

    2008-01-01

    A numerical technique for analysis of heat transfer and thermal distortion in reciprocating sliding components is proposed. In this paper we utilize the Arbitrary Lagrangian Eulerian (ALE) description where the mesh displacement can be controlled independently from the material displacement. A

  5. Aliança estratégica no canal de marketing: o caso ALE Combustíveis S.A. Strategic alliance in the marketing channel: the Ale Combustíveis S.A. case

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Garcia Cotta

    2010-01-01

    Full Text Available O artigo analisa a estratégia utilizada pela ALE Combustíveis em uma operação desenhada para vender lubrificantes automotivos em sua rede de postos. O estudo avalia as alianças efetuadas com a Elf e posteriormente com a AC Delco, revelando as motivações, escolha dos parceiros, desenho do modelo de relacionamento, gestão das alianças e avaliação do modelo adotado, confrontando a experiência prática com as prescrições da literatura. O modelo adotado, denominado broker, caracteriza-se pela preservação da autonomia das marcas, com a ALE aportando sua estrutura e força de vendas, e o parceiro, a logística de reabastecimento e processamento de pedidos. O método do caso foi adotado como estratégia de pesquisa e o relato revela o acerto na escolha do modelo, porém falhas estratégicas na capacidade operacional e posicionamento do produto, na aliança com a Elf, e na relação de forças no canal, na aliança com a AC Delco, conduziram ao fracasso de ambas as tentativas.This paper analyses the strategy adopted by ALE Combustíveis, a Brazilian Company, in an operation designed to sell automotive lubricants at gas stations. This study reviews the alliances made with Elf and later with AC Delco, exposing ALE's motivations, partner selection, design of relationship model, alliance management and assessment of adopted model, confronting practical experience with prescriptions in the published literature. The model, named broker, is characterized by preservation of the brand's autonomy, with ALE contributing its structure and sales force, and its partner, in turn, the fuelling logistics and order processing. The case method was adopted as a research strategy and this report shows how successful the model selection proved, as well as the strategic blunders related to the operational capacity and product positioning, in the alliance with Elf, and in the forces of management interrelations within the channel, in the AC Delco alliance case

  6. Voxel-Based Morphometry ALE meta-analysis of Bipolar Disorder

    Science.gov (United States)

    Magana, Omar; Laird, Robert

    2012-03-01

    A meta-analysis was performed independently to view the changes in gray matter (GM) on patients with Bipolar disorder (BP). The meta-analysis was conducted on a Talairach Space using GingerALE to determine the voxels and their permutation. In order to achieve the data acquisition, published experiments and similar research studies were uploaded onto the online Voxel-Based Morphometry database (VBM). By doing so, coordinates of activation locations were extracted from Bipolar disorder related journals utilizing Sleuth. Once the coordinates of given experiments were selected and imported to GingerALE, a Gaussian was performed on all foci points to create the concentration points of GM on BP patients. The results included volume reductions and variations of GM between Normal Healthy controls and Patients with Bipolar disorder. A significant amount of GM clusters were obtained in Normal Healthy controls over BP patients on the right precentral gyrus, right anterior cingulate, and the left inferior frontal gyrus. In future research, more published journals could be uploaded onto the database and another VBM meta-analysis could be performed including more activation coordinates or a variation of age groups.

  7. Chemistry of magmatic gases from Erta'Ale, Ethiopia

    Energy Technology Data Exchange (ETDEWEB)

    Giggenbach, W.F. (Dept. of Scientific and Industrial Research, Petone, New Zealand); Le Guern, F.

    1976-01-01

    The chemical composition of the gases emitted from a hornito close to the active lava lake of Erta'Ale, Ethiopia, as derived from chemical analyses on 18 samples collected on 23 January 1974, was found to be (in mol-percent): H/sub 2/O: 79.4; CO/sub 2/: 10.4, total S: 7.36, HCl: 0.42, H/sub 2/: 1.49, N/sub 2/: 0.18, Ar: 0.001, CO: 0.46, and COS: 0.009. Thermodynamic considerations, based on the equilibria CO/sub 2/ + H/sub 2/ reversible CO + H/sub 2/O and CO/sub 2/ + 3H/sub 2/ + SO/sub 2/ reversible COS + 3H/sub 2/O show that the analytical values represent the equilibrium composition of a gas mixture at the measured temperature of around 1130/sup 0/C under close to the surface pressure conditions. Comparison of the Erta'Ale gas emissions with those from other volcanoes suggests a close similarity in their chemical composition. This similarity is considered to be due to common processes governing the release of gaseous species from a magma.

  8. Control de brazo electrónico usando señales electromiográficas

    Directory of Open Access Journals (Sweden)

    Jorge Andrés García-Pinzón

    2015-05-01

    Full Text Available Los trabajos enfocados en la extracción de patrones en señales electromiográficas (SEMG han venido creciendo debido a sus múltiples aplicaciones. En este artículo se presenta una aplicación en la cual se implementa un sistema electrónico para el registro de las SEMG de la extremidad superior en un sujeto, con el fin de controlar de forma remota un brazo electrónico. Se realizó una etapa de preprocesamiento de las señales registradas, para eliminar información poco relevante, y reconocimiento de zonas de interés; enseguida se extraen los patrones y se clasifican. Las técnicas utilizadas fueron: análisis wavelet (AW, análisis de componentes principales (ACP, transformada de fourier (TF, transformada del coseno discreta (TDC, energía, máquinas de soporte vectorial (MSV o SVM y redes neuronales (RNA. En este artículo se demuestra que la metodología planteada permite realizar un proceso de clasificación con un rendimiento superior al 95%. Se registraron más de 4000 señales.

  9. Cryptanalysis of the Sodark Family of Cipher Algorithms

    Science.gov (United States)

    2017-09-01

    software project for building three-bit LUT circuit representations of S- boxes is available as a GitHub repository [40]. It contains several improvements...DISTRIBUTION / AVAILABILITY STATEMENT Approved for public release. Distribution is unlimited. 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The...second- and third-generation automatic link establishment (ALE) systems for high frequency radios. Radios utilizing ALE technology are in use by a

  10. El uso de señales en el análisis de coyuntura

    Directory of Open Access Journals (Sweden)

    Eduardo Espinoza

    2012-07-01

    Full Text Available Resumen El análisis y seguimiento de la coyuntura económica resultan ser unas de las principales tareas de las autoridades monetarias y organismos internacionales, de tal manera que las herramientas inherentes a esta tarea deben ser utilizadas en forma apropiada y tener una correcta interpretación. Dentro de este contexto el uso de señales extraídas del comportamiento de las series económicas resulta frecuente en los diversos análisis de coyuntura realizados por los bancos centrales de Centroamérica y República Dominicana. Este documento somete a revisión las principales señales utilizadas en los informes de esos análisis, comparando las ventajas en el uso de tasas de variación mensual, interanual, acumulada, anualizada, entre otras. Todo esto en preámbulo a la recomendación sobre las señales adecuadas para el seguimiento de dos variables fundamentales en la coyuntura económica: los precios y la producción. Palabras Claves: Análisis de coyuntura, extracción de señales, tasas de crecimiento interanual, tasa de crecimiento anualizado. Abstract Analysis and monitoring of any economic situation are the primary tasks of monetary authorities and international organizations and, as such, the tools inherent to this task require appropriate use and interpretation. With this context in mind, the use of extracted behavioral signs in an economic series is common in several conjunctive analyses performed by the central banks in Central America and the Dominican Republic. This document is subject to review of the main signals used in these reports comparing, for example, the advantages in using monthly, inter-annual, cumulative or annualized rates of change, among others. All this is in the preamble to the final recommendation of the appropriate signals to the monitoring of two key variables in the economic conjuncture: prices and production. Keywords: conjuncture analysis, signal extraction, interannual growth rates, annualized growth

  11. Stability profile of flavour-active ester compounds in ale and lager ...

    African Journals Online (AJOL)

    User

    2013-01-30

    Jan 30, 2013 ... Currently, one of the main quality problems of beer is the change of its chemical composition during storage, which alters its sensory properties. In this study, ale and lager beers were produced and aged for three months at two storage temperatures. Concentration of volatile ester compounds (VECs) in the.

  12. Dispositivo de asistencia a discapacitados motores: switch controlado por señales electromiográficas

    OpenAIRE

    Haberman, Marcelo; Spinelli, Enrique Mario

    2013-01-01

    En el presente trabajo, se propone la utilización de señales de EMG. Estas señales tienen su origen en los potenciales eléctricos (potenciales de acción) que se desarrollan en las membranas de las fibras musculares al intentar contraer un músculo. La detección de una contracción muscular, por más débil que sea, permite establecer una vía de comunicación alternativa entre un usuario y su entorno. En este sentido, se ha desarrollo de un sistema completo que, a partir de la detección de una cont...

  13. Free surface modeling of contacting solid metal flows employing the ALE formulation

    NARCIS (Netherlands)

    van der Stelt, A.A.; Bor, Teunis Cornelis; Geijselaers, Hubertus J.M.; Akkerman, Remko; Huetink, Han; Merklein, M.; Hagenah, H.

    2012-01-01

    In this paper, a numerical problem with contacting solid metal flows is presented and solved with an arbitrary Lagrangian-Eulerian (ALE) finite element method. The problem consists of two domains which mechanically interact with each other. For this simulation a new free surface boundary condition

  14. In vitro influence of 2% chlorhexidine on links established at the ...

    African Journals Online (AJOL)

    Cornel Boitor

    2013-03-20

    Mar 20, 2013 ... teeth of each group were subjected to the bonding strength tests after 24 h and ... longevity of composite materials to tooth structure is determined by the links established in the hybrid layer between the network of collagen fibers in dentin and fluid .... a well-known general antibacterial agent for endodontic.

  15. The Relationship between Language Functions and Character Types in "Noon- Valghalam" by Jalal-Ale-Ahmad

    Directory of Open Access Journals (Sweden)

    Dr. S. A. Parsa

    Full Text Available Making harmony among language functions of story characters with their character types, is one of the characteristics and advantages of modern and successful story writing. In traditional storied literature in Iran (prose and verse, this point is not considered important and story characters, generally, tell in narrator or writers way of speaking and since there is the narrators statement, they are not the representativeness of their class and character type. Not paying attention to this subject, causes disorder in either making supposition of reality or personifying, which are both important principals of story telling. This study, identifies the story of " Noon Val Ghalam" of Jalal- Ale- Ahmad who is a contemporary writer aspect. The methodology is qualitative, and data collection is based on content–analysis and document- analysis. As Ale- Ahmad was one of the Iranian contemporary writers and was familiar with western and Iranian writers, he was expected that the language and way of describing story characters he made, be based on the social class. But this study, by stating different proofs, shows that, this writer ignores the relationship necessary for language functions and character type among characters in the story and because of the imposition of his knowledge, statement and political and social view, the independence of the protagonists in his story is not well-concidered. The inflection of political and social thoughts of each writer among his works, is not a shortfall by it self, but representing of speeches in protagonists, in the way which is not in harmony with their characters, lowering the importance of then is based or an instrument for specific social and political representatives. This action not only shows the character. The specific characters, but also disorders the processing of one important issue in story conversation. Since in each language people from different social groups, use almost the same vocabularies that

  16. Flocculation in ale brewing strains of Saccharomyces cerevisiae: re-evaluation of the role of cell surface charge and hydrophobicity.

    Science.gov (United States)

    Holle, Ann Van; Machado, Manuela D; Soares, Eduardo V

    2012-02-01

    Flocculation is an eco-friendly process of cell separation, which has been traditionally exploited by the brewing industry. Cell surface charge (CSC), cell surface hydrophobicity (CSH) and the presence of active flocculins, during the growth of two (NCYC 1195 and NCYC 1214) ale brewing flocculent strains, belonging to the NewFlo phenotype, were examined. Ale strains, in exponential phase of growth, were not flocculent and did not present active flocculent lectins on the cell surface; in contrast, the same strains, in stationary phase of growth, were highly flocculent (>98%) and presented a hydrophobicity of approximately three to seven times higher than in exponential phase. No relationship between growth phase, flocculation and CSC was observed. For comparative purposes, a constitutively flocculent strain (S646-1B) and its isogenic non-flocculent strain (S646-8D) were also used. The treatment of ale brewing and S646-1B strains with pronase E originated a loss of flocculation and a strong reduction of CSH; S646-1B pronase E-treated cells displayed a similar CSH as the non-treated S646-8D cells. The treatment of the S646-8D strain with protease did not reduce CSH. In conclusion, the increase of CSH observed at the onset of flocculation of ale strains is a consequence of the presence of flocculins on the yeast cell surface and not the cause of yeast flocculation. CSH and CSC play a minor role in the auto-aggregation of the ale strains since the degree of flocculation is defined, primarily, by the presence of active flocculins on the yeast cell wall.

  17. ALE Meta-Analysis of Schizophrenics Performing the N-Back Task

    Science.gov (United States)

    Harrell, Zachary

    2010-10-01

    MRI/fMRI has already proven itself as a valuable tool in the diagnosis and treatment of many illnesses of the brain, including cognitive problems. By exploiting the differences in magnetic susceptibility between oxygenated and deoxygenated hemoglobin, fMRI can measure blood flow in various regions of interest within the brain. This can determine the level of brain activity in relation to motor or cognitive functions and provide a metric for tissue damage or illness symptoms. Structural imaging techniques have shown lesions or deficiencies in tissue volumes in schizophrenics corresponding to areas primarily in the frontal and temporal lobes. These areas are currently known to be involved in working memory and attention, which many schizophrenics have trouble with. The ALE (Activation Likelihood Estimation) Meta-Analysis is able to statistically determine the significance of brain area activations based on the post-hoc combination of multiple studies. This process is useful for giving a general model of brain function in relation to a particular task designed to engage the affected areas (such as working memory for the n-back task). The advantages of the ALE Meta-Analysis include elimination of single subject anomalies, elimination of false/extremely weak activations, and verification of function/location hypotheses.

  18. Soil Sampling to Demonstrate Compliance with Department of Energy Radiological Clearance Requirements for the ALE Unit of the Hanford Reach National Monument

    Energy Technology Data Exchange (ETDEWEB)

    Fritz, Brad G.; Dirkes, Roger L.; Napier, Bruce A.

    2007-04-01

    The Hanford Reach National Monument consists of several units, one of which is the Fitzner/Eberhardt Arid Lands Ecology Reserve (ALE) Unit. This unit is approximately 311 km2 of shrub-steppe habitat located to the south and west of Highway 240. To fulfill internal U. S. Department of Energy (DOE) requirements prior to any radiological clearance of land, DOE must evaluate the potential for residual radioactive contamination on this land and determine compliance with the requirements of DOE Order 5400.5. Historical soil monitoring conducted on ALE indicated soil concentrations of radionuclides were well below the Authorized Limits. However, the historical sampling was done at a limited number of sampling locations. Therefore, additional soil sampling was conducted to determine if the concentrations of radionuclides in soil on the ALE Unit were below the Authorized Limits. This report contains the results of 50 additional soil samples. The 50 soil samples collected from the ALE Unit all had concentrations of radionuclides far below the Authorized Limits. The average concentrations for all detectable radionuclides were less than the estimated Hanford Site background. Furthermore, the maximum observed soil concentrations for the radionuclides included in the Authorized Limits would result in a potential annual dose of 0.14 mrem assuming the most probable use scenario, a recreational visitor. This potential dose is well below the DOE 100-mrem per year dose limit for a member of the public. Spatial analysis of the results indicated no observable statistically significant differences between radionuclide concentrations across the ALE Unit. Furthermore, the results of the biota dose assessment screen, which used the ResRad Biota code, indicated that the concentrations of radionuclides in ALE Unit soil pose no significant health risk to biota.

  19. Lagrangian and ALE Formulations For Soil Structure Coupling with Explosive Detonation

    Directory of Open Access Journals (Sweden)

    M Souli

    2017-03-01

    Full Text Available Simulation of Soil-Structure Interaction becomes more and more the focus of computational engineering in civil and mechanical engineering, where FEM (Finite element Methods for structural and soil mechanics and Finite Volume for CFD are dominant. New formulations have been developed for FSI applications using ALE (Arbitrary Lagrangian Eulerian and mesh free methods as SPH method, (Smooth Particle Hydrodynamic. In defence industry, engineers have been developing protection systems for many years to reduce the vulnerability of light armoured vehicles (LAV against mine blast using classical Lagrangian FEM methods. To improve simulations and assist in the development of these protections, experimental tests, and new numerical techniques are performed. To carry out these numerical calculations, initial conditions such as the loading prescribed by a mine on a structure need to be simulated adequately. The effects of blast on structures depend often on how these initial conditions are estimated and applied. In this report, two methods were used to simulate a mine blast: the classical Lagrangian and the ALE formulations. The comparative study was done for a simple and a more complex target. Particle methods as SPH method can also be used for soil structure interaction.

  20. Transformadas Wavelet impacto fundamental en Procesamiento de señales y compresión de imágenes

    OpenAIRE

    González Arboleda, José Rodrigo

    2014-01-01

    En este trabajo se mostrará el concepto de Transformadas de Fourier y Transformadas Wavelet, sus propiedades, teoremas, proposiciones que las soportan. Se mostrará soluciones en series de Fourier que representan a las soluciones de procesamiento de señales y la Transformada Wavelet que permite la compresión de datos e imágenes. En general, el procesamiento de señales y en particular, la compresión de imágenes es una de las necesidades más importantes en aplicaciones como la codificación y ...

  1. Compatible, energy conserving, bounds preserving remap of hydrodynamic fields for an extended ALE scheme

    Science.gov (United States)

    Burton, D. E.; Morgan, N. R.; Charest, M. R. J.; Kenamond, M. A.; Fung, J.

    2018-02-01

    From the very origins of numerical hydrodynamics in the Lagrangian work of von Neumann and Richtmyer [83], the issue of total energy conservation as well as entropy production has been problematic. Because of well known problems with mesh deformation, Lagrangian schemes have evolved into Arbitrary Lagrangian-Eulerian (ALE) methods [39] that combine the best properties of Lagrangian and Eulerian methods. Energy issues have persisted for this class of methods. We believe that fundamental issues of energy conservation and entropy production in ALE require further examination. The context of the paper is an ALE scheme that is extended in the sense that it permits cyclic or periodic remap of data between grids of the same or differing connectivity. The principal design goals for a remap method then consist of total energy conservation, bounded internal energy, and compatibility of kinetic energy and momentum. We also have secondary objectives of limiting velocity and stress in a non-directional manner, keeping primitive variables monotone, and providing a higher than second order reconstruction of remapped variables. In particular, the new contributions fall into three categories associated with: energy conservation and entropy production, reconstruction and bounds preservation of scalar and tensor fields, and conservative remap of nonlinear fields. The paper presents a derivation of the methods, details of implementation, and numerical results for a number of test problems. The methods requires volume integration of polynomial functions in polytopal cells with planar facets, and the requisite expressions are derived for arbitrary order.

  2. ADQUISICIÓN Y PROCESAMIENTO DE SEÑALES EMG PARA CONTROLAR MOVIMIENTO DE UN BRAZO HIDRAULICO

    Directory of Open Access Journals (Sweden)

    Jorge Andrés García Pinzon

    2014-06-01

    Full Text Available En este artículo se presenta el diseño e implementación de un sistema electrónico para el registro de las señales electromiográficas de la extremidad superior del sujeto (humano. Seguidamente al proceso de la implementación del sistema electrónico, en este trabajo se realiza una etapa de pre-procesamiento y procesamiento de las señales registradas, las técnicas utilizadas para éste fin son: análisis wavelet (AW, análisis de componentes principales (ACP, transformada de fourier (TF, transformada del coseno discreta (DCT, máquinas de soporte vectorial (SVM y redes neuronales artificiales (RNA; estas técnicas se usaron para eliminar información poco relevante, reconocer zonas de interés, extraer patrones en cada grupo de señales y clasificar una nueva señal que controle en forma precisa el movimiento que quiere ejecutar el sujeto con el brazo Hidráulico. Dentro de las técnicas de control de procesos Industriales se busca realizar una aplicación con el fin de poder hacer control a dos grados de libertad más el efector final del brazo hidráulico del laboratorio de automatización y mantenimiento de equipos industriales de la Universidad de Pamplona.

  3. La dialyse péritonéale chez les patients de moins de vingt ans ...

    African Journals Online (AJOL)

    La dialyse péritonéale chez les patients de moins de vingt ans: expérience d'un centre hospitalier universitaire marocain. Intissar Haddiya, Hakima Rhou, Fatima Ezaitouni, Naima Ouzeddoun, Rabia Bayahia, Loubna Benamar ...

  4. Magmatic architecture within a rift segment: Articulate axial magma storage at Erta Ale volcano, Ethiopia

    Science.gov (United States)

    Xu, Wenbin; Rivalta, Eleonora; Li, Xing

    2017-10-01

    Understanding the magmatic systems beneath rift volcanoes provides insights into the deeper processes associated with rift architecture and development. At the slow spreading Erta Ale segment (Afar, Ethiopia) transition from continental rifting to seafloor spreading is ongoing on land. A lava lake has been documented since the twentieth century at the summit of the Erta Ale volcano and acts as an indicator of the pressure of its magma reservoir. However, the structure of the plumbing system of the volcano feeding such persistent active lava lake and the mechanisms controlling the architecture of magma storage remain unclear. Here, we combine high-resolution satellite optical imagery and radar interferometry (InSAR) to infer the shape, location and orientation of the conduits feeding the 2017 Erta Ale eruption. We show that the lava lake was rooted in a vertical dike-shaped reservoir that had been inflating prior to the eruption. The magma was subsequently transferred into a shallower feeder dike. We also find a shallow, horizontal magma lens elongated along axis inflating beneath the volcano during the later period of the eruption. Edifice stress modeling suggests the hydraulically connected system of horizontal and vertical thin magmatic bodies able to open and close are arranged spatially according to stresses induced by loading and unloading due to topographic changes. Our combined approach may provide new constraints on the organization of magma plumbing systems beneath volcanoes in continental and marine settings.

  5. Optimization studies of HgSe thin film deposition by electrochemical atomic layer epitaxy (EC-ALE)

    CSIR Research Space (South Africa)

    Venkatasamy, V

    2006-06-01

    Full Text Available Studies of the optimization of HgSe thin film deposition using electrochemical atomic layer epitaxy (EC-ALE) are reported. Cyclic voltammetry was used to obtain approximate deposition potentials for each element. These potentials were then coupled...

  6. FENOMENOLOGIA DELLA RELIGIONE DI ANGELA ALES BELLO (PHENOMENOLOGY OF RELIGION IN THE VISION OF ANGELA ALES BELLO

    Directory of Open Access Journals (Sweden)

    MOBEEN SHAHID

    2015-11-01

    Full Text Available If sacred in any way is a vehicle of religious experience there is nothing new about what it is vehicle of but if we focalize on what sacred is in itself we need a method to do so and in this regard I would mention the need of analyzing what the philosophical school of phenomenology of religion in and from Italy has been working on in the person of Angela Ales Bello as its Maestro in particular in last four decades. Several works of the author have paved the path, considering various points in scientific articles and texts but the main conceptual map is developed in the following three: Culture e religioni. Una lettura fenomenologica, Citta Nuova, Roma, 1997; a co-authored work with me Lineamenti di Antropologia Filosofica: Fenomenologia della religione ed esperienza mistica islamica, Editrice Apes, Roma, 2012; and the latest Il senso del sacro. Dall’arcaicità alla desacralizzazione, Castelvecchi, Roma, 2014.

  7. Establishing a Statistical Link between Network Oscillations and Neural Synchrony.

    Directory of Open Access Journals (Sweden)

    Pengcheng Zhou

    2015-10-01

    Full Text Available Pairs of active neurons frequently fire action potentials or "spikes" nearly synchronously (i.e., within 5 ms of each other. This spike synchrony may occur by chance, based solely on the neurons' fluctuating firing patterns, or it may occur too frequently to be explicable by chance alone. When spike synchrony above chances levels is present, it may subserve computation for a specific cognitive process, or it could be an irrelevant byproduct of such computation. Either way, spike synchrony is a feature of neural data that should be explained. A point process regression framework has been developed previously for this purpose, using generalized linear models (GLMs. In this framework, the observed number of synchronous spikes is compared to the number predicted by chance under varying assumptions about the factors that affect each of the individual neuron's firing-rate functions. An important possible source of spike synchrony is network-wide oscillations, which may provide an essential mechanism of network information flow. To establish the statistical link between spike synchrony and network-wide oscillations, we have integrated oscillatory field potentials into our point process regression framework. We first extended a previously-published model of spike-field association and showed that we could recover phase relationships between oscillatory field potentials and firing rates. We then used this new framework to demonstrate the statistical relationship between oscillatory field potentials and spike synchrony in: 1 simulated neurons, 2 in vitro recordings of hippocampal CA1 pyramidal cells, and 3 in vivo recordings of neocortical V4 neurons. Our results provide a rigorous method for establishing a statistical link between network oscillations and neural synchrony.

  8. Les bienfaits pour la santé et la prédominance du sucre dans les céréales pour déjeuner destinées aux enfants au Canada

    Directory of Open Access Journals (Sweden)

    Monique Potvin Kent

    2017-01-01

    Full Text Available Introduction : Cette étude vise à comparer le contenu nutritionnel et les bienfaits pour la santé des céréales pour déjeuner destinées aux enfants et celles non destinées aux enfants et à évaluer la prédominance du sucre ajouté dans ces produits. Méthodologie : Nous avons recueilli des données sur le contenu nutritionnel de 262 céréales pour déjeuner vendues dans les cinq principales chaînes d’alimentation à Ottawa (Ontario et à Gatineau (Québec. Pour chaque céréale, nous avons pris en note les cinq premiers ingrédients et la quantité de sucres ajoutés indiqués sur la liste des ingrédients. Les diverses marques de céréales ont été ensuite classées en deux catégories, soit « plus saines » ou « moins saines », à l’aide du modèle de profil nutritionnel du Royaume-Uni. Nous avons évalué chaque céréale en fonction de divers critères afin de déterminer si elle était destinée ou non aux enfants. Des comparaisons statistiques ont été établies entre les céréales destinées aux enfants et les autres. Résultats : Sur l'ensemble des céréales pour déjeuner, 19,8 % étaient destinées aux enfants et contenaient beaucoup moins de gras et de gras saturés. Ces céréales avaient une teneur en sodium et en sucre significativement plus élevée et une teneur en fibres et en protéines plus faible, et elles étaient trois fois plus susceptibles d’être classées comme « moins saines » par rapport aux céréales non destinées aux enfants. Aucune des céréales destinées aux enfants n’était sans sucre et, pour 75 % d’entre elles, le sucre occupait le deuxième rang dans la liste des ingrédients. Six entreprises de céréales pour déjeuner possédaient une gamme de produits destinés aux enfants composée entièrement de céréales « moins saines ». Conclusion : Il est nécessaire d’adopter un règlement qui limite le marketing alimentaire ciblant les enfants et les jeunes de moins de 17

  9. The impact of different ale brewer’s yeast strains on the proteome of immature beer

    DEFF Research Database (Denmark)

    Berner, Torben Sune; Jacobsen, Susanne; Arneborg, Nils

    2013-01-01

    BACKGROUND: It is well known that brewer’s yeast affects the taste and aroma of beer. However, the influence of brewer’s yeast on the protein composition of beer is currently unknown. In this study, changes of the proteome of immature beer, i.e. beer that has not been matured after fermentation......, by ale brewer’s yeast strains with different abilities to degrade fermentable sugars were investigated. RESULTS: Beers were fermented from standard hopped wort (13° Plato) using two ale brewer’s yeast (Saccharomyces cerevisiae) strains with different attenuation degrees. Both immature beers had the same....... These three proteins, all derived from yeast, were identified as cell wall associated proteins, that is Exg1 (an exo-β-1,3-glucanase), Bgl2 (an endo-β-1,2-glucanase), and Uth1 (a cell wall biogenesis protein). CONCLUSION: Yeast strain dependent changes in the immature beer proteome were identified, i.e. Bgl2...

  10. Diseño y construcción de un módulo didáctico para la adquisición y análisis de señales ECG, EEG y EMG

    OpenAIRE

    Valencia Brito, Efraín Issrael; Villa Parra, Flavio Fernando

    2013-01-01

    En este documento se describe el desarrollo de un módulo didáctico que permite la adquisición y presentación de la información de las señales ECG, EEG y EMG para el desarrollo de prácticas que se espera aporte a la enseñanza y estudio de las bioseñales a estudiantes de Ingeniería. Para este fin se aplicaron conceptos de adquisición, digitalización, visualización y análisis de señales a nivel de hardware y de software. Las señales se adquieren con electrodos superficiales y para el caso de ...

  11. Brewhouse-resident microbiota are responsible for multi-stage fermentation of American coolship ale.

    Directory of Open Access Journals (Sweden)

    Nicholas A Bokulich

    Full Text Available American coolship ale (ACA is a type of spontaneously fermented beer that employs production methods similar to traditional Belgian lambic. In spite of its growing popularity in the American craft-brewing sector, the fermentation microbiology of ACA has not been previously described, and thus the interface between production methodology and microbial community structure is unexplored. Using terminal restriction fragment length polymorphism (TRFLP, barcoded amplicon sequencing (BAS, quantitative PCR (qPCR and culture-dependent analysis, ACA fermentations were shown to follow a consistent fermentation progression, initially dominated by Enterobacteriaceae and a range of oxidative yeasts in the first month, then ceding to Saccharomyces spp. and Lactobacillales for the following year. After one year of fermentation, Brettanomyces bruxellensis was the dominant yeast population (occasionally accompanied by minor populations of Candida spp., Pichia spp., and other yeasts and Lactobacillales remained dominant, though various aerobic bacteria became more prevalent. This work demonstrates that ACA exhibits a conserved core microbial succession in absence of inoculation, supporting the role of a resident brewhouse microbiota. These findings establish this core microbial profile of spontaneous beer fermentations as a target for production control points and quality standards for these beers.

  12. The Montana ALE (Autonomous Lunar Excavator) Systems Engineering Report

    Science.gov (United States)

    Hull, Bethanne J.

    2012-01-01

    On May 2 1-26, 20 12, the third annual NASA Lunabotics Mining Competition will be held at the Kennedy Space Center in Florida. This event brings together student teams from universities around the world to compete in an engineering challenge. Each team must design, build and operate a robotic excavator that can collect artificial lunar soil and deposit it at a target location. Montana State University, Bozeman, is one of the institutions selected to field a team this year. This paper will summarize the goals of MSU's lunar excavator project, known as the Autonomous Lunar Explorer (ALE), along with the engineering process that the MSU team is using to fulfill these goals, according to NASA's systems engineering guidelines.

  13. Diseño y desarrollo de un sistema para la adquisición de señales de electrocardiografía (ECG)

    OpenAIRE

    BASELGA MEMBRIVE, MARÍA

    2015-01-01

    [ES] Las células excitables de nuestro organismo generan unas señales eléctricas muy importantes (centenares de milivoltios) que, sin embargo, llegan muy atenuadas (microvoltios o pocos milivoltios) a la superficie del cuerpo humano debido a que internamente somos muy buenos conductores. La utilización de señales bioeléctricas como el electrocardiograma ECG, electroencefalograma EEG o electromiograma EMG, entre otras, se ha convertido en una rutina clínica para el diagnóstico de diferentes pa...

  14. Aspecte morfometrice ale meiocitelor şi grăuncioarelor de polen la plantele de floarea–soarelui cu androsterilitate indusă

    Directory of Open Access Journals (Sweden)

    Victoria NECHIFOR

    2017-12-01

    Full Text Available Morphometric characterization is an important element in the study of dynamic cellular behavior in plant responses to biotic and abiotic stimuli. The aim of study was to determine the morphometric parameters of meiocytes and pollen grains in different phases of microsporogenesis in fertile and induced androsterility sunflower plants. Thus, the comparative morphometric analysis revealed the gametocidal effect of gibberellin that is manifested as abnormal changes in shape and volume of cells. These modifications lead to deficiencies in the integrity/rigidity and, respectively, in the functionality of the cell wall, as well as in the physical properties of the protoplasm. The low values of morphometric parameters were also correlated with the degree of sterility of pollen grains. Rezumat. Caracterizarea morfometrică este un element important în studiul proceselor celulare dinamice ca răspuns la stimulii biotici şi abiotici. Scopul studiului constă în determinarea parametrilor morfometrici ai meiocitelor şi grăuncioarelor de polen în diferite faze ale microsporogenezei la plantele de floarea-soarelui fertile şi cu androsterilitate indusă. Astfel, analiza morfometrică comparativă a relevat efectul gametocid al giberelinei exprimat prin schimbările anormale ale formei şi volumului celulelor. Aceste modificări induc deficienţe atât în integritatea/rigiditatea şi, respectiv, în funcţionalitatea peretelui celular, cât şi în proprietăţile fizice ale protoplasmei. De asemenea, valorile scăzute ale parametrilor morfometrici au fost corelate cu gradul de sterilitate al grăuncioarelor de polen.

  15. BOOK REVIEW - Adrian Liviu Ivan, Teorii și practice ale integrării europene [Theories and Practices of European Integration

    Directory of Open Access Journals (Sweden)

    Adrian Daniel STAN

    2016-06-01

    Full Text Available Teorii și practice ale integrării europene [Theories and Practices of European Integration] is a genuine contribution to understanding how the European Union’s particular character has been adjusted in more than half of century of institutional growth and development. Professor Ivan`s key argument for this book is that the European Union has been shaped as a functional project taking into consideration the diverse heritage and traditions of its Member States. The opening chapter of this book focuses on the particularities of international relations discipline after the Second World War in order to introduce the theme of European Integration Process. This chapter must be analysed in a series of contributions dedicated to the European Integration process and to the theories that made this integration possible because professor Ivan has previously published books such as: Statele Unite ale Europei [The United States of Europe], Sub zodia Statelor Unite ale Europei [Under the Sign of the United States of Europe], in which he debates the origins of the European construction and brings forward arguments to support the importance of each theoretical and functional pillar of this “Common European Project”.

  16. VALORI POSTEXPERIMENTALE ALE CULTURII MANAGERIALE ÎN INSTITUŢIA PREŞCOLARĂ

    Directory of Open Access Journals (Sweden)

    Victoria COJOCARU

    2015-12-01

    Full Text Available Prezentul articol reflectă analiza datelor experimentului de control la tema: Valoarea metodologică a culturii mana-geriale în instituţia preşcolară, unde sunt prezentate pe niveluri rezultatele comparative ale grupelor de manageri şi masteranzi implicaţi în experimentul formativ. THE POSTEXPERIMENTAL VALUES OF MANAGERIAL CULTURE IN THE PRESCHOOL INSTITUTIONThis article reflects the analysis control experiment data of subjects The methodological value of managerial culture in preschool, where are presented comparative results of managers and masters by levels of evidence developed at this stage.

  17. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  18. Vajilla de mesa (terra sigillata y cerámica engobada de la ciudad romana de Los Bañales (Uncastillo, Zaragoza = Roman Pottery (terra sigillata and engobada at the archaeological site of Los Bañales (Uncastillo, Zaragoza

    Directory of Open Access Journals (Sweden)

    Elena Lasaosa Pardo

    2014-12-01

    Full Text Available En el presente trabajo se presenta la vajilla de mesa (terra sigillata y cerámica engobada que consta entre los materiales cerámicos de la ciudad romana de Los Bañales (Uncastillo, Zaragoza, recuperados en los años setenta del siglo pasado por Antonio Beltrán Martínez. Con este trabajo se pretende aportar datos que ayuden en el estudio de la antigua ciudad ubicada en el lugar y enriquezcan la investigación que hay en ella y que ha sido retomada en los últimos años para el mejor conocimiento, conservación, puesta en valor y difusión de la ciudad.In the following pages, the material culture results, specifically terra sigillata and engobada pottery, obtained from a series of archaeological interventions undertaken in the 1970’s by the lecturer Antonio Beltrán, at the archeological site of Los Bañales (Uncastillo, Zaragoza, are presented. The aim of this article is to increase the information available on these ceramics and to provide a contribution towards a greater understanding of the historical city of Los Bañales. This study will also assist recent archaeological investigations on this historic site, by providing better information on the form, chronology and use of these ceramics and by communicating the results of this study to both the researchers and the interested public. It will also contribute to the culture heritage of Uncastillo through the conservation of the ceramic evidence and the public display of this material culture.

  19. Overview of SPH-ALE applications for hydraulic turbines in ANDRITZ Hydro

    Science.gov (United States)

    Rentschler, M.; Marongiu, J. C.; Neuhauser, M.; Parkinson, E.

    2018-02-01

    Over the past 13 years, ANDRITZ Hydro has developed an in-house tool based on the SPH-ALE method for applications in flow simulations in hydraulic turbines. The initial motivation is related to the challenging simulation of free surface flows in Pelton turbines, where highly dynamic water jets interact with rotating buckets, creating thin water jets traveling inside the housing and possibly causing disturbances on the runner. The present paper proposes an overview of industrial applications allowed by the developed tool, including design evaluation of Pelton runners and casings, transient operation of Pelton units and free surface flows in hydraulic structures.

  20. The Neural Bases of Difficult Speech Comprehension and Speech Production: Two Activation Likelihood Estimation (ALE) Meta-Analyses

    Science.gov (United States)

    Adank, Patti

    2012-01-01

    The role of speech production mechanisms in difficult speech comprehension is the subject of on-going debate in speech science. Two Activation Likelihood Estimation (ALE) analyses were conducted on neuroimaging studies investigating difficult speech comprehension or speech production. Meta-analysis 1 included 10 studies contrasting comprehension…

  1. Trayectoria religiosa de un clérigo español a principios del siglo xix. La figura de Rafael Crisanto Alesón

    Directory of Open Access Journals (Sweden)

    Rebeca Viguera Ruiz

    2015-01-01

    Full Text Available In the Spanish situation of major transformations that occurred between the eighteenth and nineteenth century, citizens of all social classes and professional occupations were the true architects of all cultural, ideological and political changes that took place. In an attempt to better understand the essence of some of these popular and religious social components, this paper aims to briefly present the most relevant biographical notes about Rafael D. Crisanto Alesón Alesón as a first approach to his life. Alesón was a character who lived between those two centuries which meant the emergence of the Enlightenment firstly and liberalism thereafter, that would eventually overthrow the Old Regime monarchy. A man of the Church, well educated, who enjoyed a comfortable economic status that gave him a good education and high social consideration from his neighbors. These pages seek to define this religious figure who, from a local level and a humble exercise of his religious ministry, helped to spread the message of the Catholic faith at a time of great stress and generalized crisis in Spain.

  2. Diversity and abundance of communities of birds associated to forests semideciduos and pine encino of the National Park Viñales

    Directory of Open Access Journals (Sweden)

    Sael Hanoi Pérez Báez

    2016-06-01

    Full Text Available The present work was carried out in the months of February to April 2009 in the forest semideciduo of the path "Marvel of Viñales" and the formation pine-encino of the Valley Ancón of the National Park Viñales and it pursued as main objective to evaluate the diversity and abundance of the communities of birds and its association grade with both formations. The method of circular parcels of fixed radio was used in 30 points of counts separated to 150 m one of other and for the study of vegetation he/she took like base the methodology proposed by James and Shugart (1970 and Noon (1981 with adaptations, he/she took state fenológico of the vegetable species and they measured different variables of the formation boscosa. They were detected a total of 44 species of birds for the semidesiduo and 42 in Ancón. He/she was association between several species of birds and vegetables of the formations in study, appreciating you increment of S with the Relative Abundance and the decrease of the height of the vegetation with the vegetable density. The communities of birds of the formation of forest semideciduo of the path "Marvels of Viñales" and of the forest of pine encino of "Valley Ancón" presented similar figures of wealth, diversity and equitatividad but they sustained differences in composition and it structures. In both study formations numeric dominancias of Turdus plumbeus and Vireo altiloquus registered and the difference was given by the abundance of Teretistris fernandinae in "Marvels of Viñales" and Tiaris canorus in Valley Ancón. The relationship was demonstrated between ornitocenosis and fitocenosis and several species of birds they associated in more measure to rosy Clusea, Callophilum antillanun, Cuban Quercus, Matayba oppositifolia and Cordovan leathers.

  3. Hypnosis and pain perception: An Activation Likelihood Estimation (ALE) meta-analysis of functional neuroimaging studies.

    Science.gov (United States)

    Del Casale, Antonio; Ferracuti, Stefano; Rapinesi, Chiara; De Rossi, Pietro; Angeletti, Gloria; Sani, Gabriele; Kotzalidis, Georgios D; Girardi, Paolo

    2015-12-01

    Several studies reported that hypnosis can modulate pain perception and tolerance by affecting cortical and subcortical activity in brain regions involved in these processes. We conducted an Activation Likelihood Estimation (ALE) meta-analysis on functional neuroimaging studies of pain perception under hypnosis to identify brain activation-deactivation patterns occurring during hypnotic suggestions aiming at pain reduction, including hypnotic analgesic, pleasant, or depersonalization suggestions (HASs). We searched the PubMed, Embase and PsycInfo databases; we included papers published in peer-reviewed journals dealing with functional neuroimaging and hypnosis-modulated pain perception. The ALE meta-analysis encompassed data from 75 healthy volunteers reported in 8 functional neuroimaging studies. HASs during experimentally-induced pain compared to control conditions correlated with significant activations of the right anterior cingulate cortex (Brodmann's Area [BA] 32), left superior frontal gyrus (BA 6), and right insula, and deactivation of right midline nuclei of the thalamus. HASs during experimental pain impact both cortical and subcortical brain activity. The anterior cingulate, left superior frontal, and right insular cortices activation increases could induce a thalamic deactivation (top-down inhibition), which may correlate with reductions in pain intensity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. A Cell-Centered Multiphase ALE Scheme With Structural Coupling

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Timothy Alan [Univ. of California, Davis, CA (United States)

    2012-04-16

    A novel computational scheme has been developed for simulating compressible multiphase flows interacting with solid structures. The multiphase fluid is computed using a Godunov-type finite-volume method. This has been extended to allow computations on moving meshes using a direct arbitrary-Eulerian- Lagrangian (ALE) scheme. The method has been implemented within a Lagrangian hydrocode, which allows modeling the interaction with Lagrangian structural regions. Although the above scheme is general enough for use on many applications, the ultimate goal of the research is the simulation of heterogeneous energetic material, such as explosives or propellants. The method is powerful enough for application to all stages of the problem, including the initial burning of the material, the propagation of blast waves, and interaction with surrounding structures. The method has been tested on a number of canonical multiphase tests as well as fluid-structure interaction problems.

  5. A DETERMINAÇÃO DOS PRODUTOS AVANÇADOS DE GLICAÇÃO (AGES E DE LIPOXIDAÇÃO (ALES EM ALIMENTOS E EM SISTEMAS BIOLÓGICOS: AVANÇOS, DESAFIOS E PERSPECTIVAS

    Directory of Open Access Journals (Sweden)

    Júnia H. Porto Barbosa

    2016-06-01

    Full Text Available Advanced glycation (AGEs and lipoxidation (ALEs products are formed through specific condensation reactions between nucleophiles (amino groups of free amino acids or their residues in peptides, aminophospholipids or proteins and electrophiles (carbonyls of reducing sugars, oxidized lipids or others generating well-defined sets of covalent adducts. The ε-amino group of the lysine is the most reactive precursor in proteins and the primary target of carbohydrate attacks. AGEs/ALEs accumulation has consequences in the development of vascular, renal, neural and ocular complications, as well as in the triggering of inflammatory and neurodegenerative diseases. Therefore, AGEs/ALEs detection, quantification and, in some cases, the assessment of the extent of glycation in biomolecules of different matrices represent a factor of primary interest for science. Reliable analytical methods are thus required. Together with basic concepts, this review presents the main advances, challenges and prospects of research involving AGEs and ALEs in biological and food systems, exploring practical strategies to ensure greater reliability in the analysis of these compounds in different matrices.

  6. Active life expectancy from annual follow-up data with missing responses.

    Science.gov (United States)

    Izmirlian, G; Brock, D; Ferrucci, L; Phillips, C

    2000-03-01

    Active life expectancy (ALE) at a given age is defined as the expected remaining years free of disability. In this study, three categories of health status are defined according to the ability to perform activities of daily living independently. Several studies have used increment-decrement life tables to estimate ALE, without error analysis, from only a baseline and one follow-up interview. The present work conducts an individual-level covariate analysis using a three-state Markov chain model for multiple follow-up data. Using a logistic link, the model estimates single-year transition probabilities among states of health, accounting for missing interviews. This approach has the advantages of smoothing subsequent estimates and increased power by using all follow-ups. We compute ALE and total life expectancy from these estimated single-year transition probabilities. Variance estimates are computed using the delta method. Data from the Iowa Established Population for the Epidemiologic Study of the Elderly are used to test the effects of smoking on ALE on all 5-year age groups past 65 years, controlling for sex and education.

  7. CARACTERISTICILE GENERALE ALE LIMBAJULUI ŞTIINŢIFIC

    Directory of Open Access Journals (Sweden)

    Galina PLEŞCA

    2016-12-01

    Full Text Available Articolul prezintă un studiu al limbajului ştiinţific ca subsistem al limbajului literar, scopul căruia este de a identifica caracteristicile generale ale acestuia. Limbajul ştiinţific se adresează raţiunii şi logicii, raţiona­mentul fiind caracteristica sa de bază, iar funcţia sa de a transmite informaţii ştiinţifice, utilizate pe baza unor raţionamente logice şi deductive, este una dominantă şi serveşte în scopul informării şi educării – piloni de bază ai oricărui text ştiinţific.GENERAL CHARACTERISTICS OF THE SCIENTIFIC LANGUAGEThe article deals with the study of the scientific language as a literary language subsystem, the aim of which is to identify its general characteristics. The scientific language addresses the reason and logic, reasoning being its basic characteristic feature and its function of rendering scientific and utilitarian information based on logical and deductive reasoning is the dominant one and serves the purpose of informing and educating, basic pillars of any scientific text.

  8. Una técnica de pronóstico de señales basada en redes neuronales

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Ortiz T.

    2001-10-01

    Full Text Available El creciente interés por construir sistemas de procesamiento de señales mediante redes neuronales, especialmente durante los últimos veinte años, se debe a la posibilidad de avances significativos en campos poco explorados y cuyo manejo resulta de naturaleza compleja. Uno de estos campos es la predicción de señales. Una señal es una colección de valores que, generalmente, representan mediciones sucesivas de un evento del mundo real, los valores se toman durante un tiempo específico a intervalos regulares, representando una muestra del evento que se desea estudiar o de las características propias del mismo. La predicción de una señal consiste en obtener un conjunto de valores que, según un margen de error aceptable, constituyen una estimación del comportamiento futuro de la señal. El proceso de predicción es mucho más que la posición simplista de aventurar valores; puesto que requiere la construcción de un modelo adecuado de la dinámica del sistema a tratar.

  9. Teaching and Research: Establishing Link in Studio-Based Education

    Directory of Open Access Journals (Sweden)

    A. Ozdemyr

    2007-09-01

    Full Text Available The compelling ideal of modern architectural education associated with Boyer’s (1990 framework is a scholarly collaboration by a relationship between teaching and research. Research enhances teaching through the introduction of new topics and methodologies. Research-based teaching stimulates better communication between students and lecturers as researchers. Students’ comments and questions can improve the subject of future research. A model of research-based teaching can be structured to teach both research findings and processes. This model can be well integrated to current curriculum with emphasis on research-oriented teaching in which students take part in the research process. In this process, instructors use their research experience during their interactions with students. This paper discusses the establishment of the link between research and teaching in the built environment with cases from studio-based learning in Landscape Architecture discipline. The argument is that studio-based education should be accepted as a pedagogical method to take part in teaching research to make connections between architecture and other disciplines. This effort will position the education into a research-based setting and make proposals to re-orient curriculum so that researchers can teach what and how they research.

  10. Validación de señales vibro-acústicas para el diagnóstico de fallas en rodamientos en un generador síncrono

    OpenAIRE

    Zulma Yadira Medrano Hurtado; Carlos Pérez Tello

    2017-01-01

    En este trabajo se describe el procedimiento y las herramientas utilizados en la medición y diagnóstico de señales de vibración capturadas a través de transductores de aceleración (acelerómetros piezoeléctricos) y acústicos (micrófonos omnidireccionales). Además, se desarrolló un arreglo experimental empleando la metodología Taguchi para validar la información registrada de las señales de vibración para rodamientos sin falla y con falla artificial, respectivamente. La falla artificial consist...

  11. Señales entre hongos patógenos y plantas hospederas resistentes

    Directory of Open Access Journals (Sweden)

    G. Camarena Gutiérrez

    2001-01-01

    Full Text Available Los hongos parásitos obligados obtienen sus nutrimentos de células vivas. Durante su ciclo de vida, se forman tres tipos de estructuras intracelulares (hifa de invasión, haustorio M y haustorio D y cada uno puede afectar de manera diferente la membrana de la célula huésped que le rodea, también cómo afectar otros componentes celulares. Cada estructura intracelular también previene que se disparen defensas no específicas de la planta por la actividad del hongo, posiblemente interfiriendo el sistema de señales más que la expresión de defensa.

  12. Temperature profile data collected from the ALE ANDRO DE HUMBOLDT from 19 September 1971 to 26 September 1971 (NODC Accession 7500942)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using bottle casts from the ALE ANDRO DE HUMBOLDT in the coastal waters of California from 19 September 1971 to 26 September...

  13. Establishing the link between money laundering and tax evasion

    OpenAIRE

    Storm, Ansia

    2013-01-01

    No clear link has yet been made between tax evasion and money laundering although many (or all) of the professionals in this field may have already assumed the relation. The aim of the research that was conducted for the purposes of this article was to explore whether there is a clear link between tax evasion and money laundering. This was done by studying the relevant literature available on both subjects. The findings, that there is a clear link between these two offences, we...

  14. El yacimiento arqueológico de Los Bañales (Uncastillo, Zaragoza : ensayo de actualización

    Directory of Open Access Journals (Sweden)

    María Dolores Lasuén Alegre

    2008-01-01

    Full Text Available Los Bañales es una ciudad romana con sustrato indígena ubicada en un área de intensa romanización en el Valle Medio del Ebro, en la Tarraconensis, y que, entre sus muchas peculiaridades, presenta un sistema de abastecimiento y de aprovechamiento hidráulico con acueducto conservado notablemente singular. El estudio que aquí se presenta —que plantea una revisión arqueológica del conjunto— surge como parte de los trabajos preliminares de puesta en valor del yacimiento y de su Plan de Investigación.Los Bañales is a Roman city with indigenous substract, situated in a very intense romanized area in the middle of the Ebro Valley, in Taraconensis province. Between its important singularities, it also presents a supply and hydric use system with a very singular thermae and aqueduct system. This study —that tryes to do a review of the archeological site— comes out as part of a previous and current research-work, related to the rehabilitation of the archaeological site and with its current Researching Plan.

  15. PROBLEME ACTUALE ALE CERCETĂRII TEXTULUI DE VULGARIZARE MEDICALĂ MEDIATIZAT

    Directory of Open Access Journals (Sweden)

    Aia DAVID

    2018-05-01

    Full Text Available În articol sunt identificate caracteristicile lingvopragmatice ale textului de vulgarizare medicală mediatizat. Din perspectivă lingvistică și interacțională, textul medical prezintă anumite caracteristici identitare, cum ar fi lexicul, obiectivitatea, intertextualitatea specifică etc. Analiza parcursului textelor medicale spre publicul nespecialist permite delimitarea tehnicilor de vulgarizare prin folosirea figurilor de stil, reformulare, folosirea metalimbajului și a substi­tuirilor sinonimice.ACTUAL PROBLEMS IN THE RESEARCH OF THE MEDIATIZED TEXT  OF MEDICAL POPULARIZATIONThe purpose of this article is to identify the linguistic and pragmatic features of the mediatized text of medical popularization. From the linguistic and interactive perspectives, the medical text presents certain identifying features, such as vocabulary, objectivity, specific intertextuality, etc. The analysis of the medical texts course towards the non-specialist public allows delimitation of the popularization techniques using style figures, reformulation, meta-language and synonymous substitutions.

  16. PHYTOPLANKTON - WET WEIGHT and Other Data from ALE ANDRO DE HUMBOLDT From North Pacific Ocean from 19780108 to 19780407 (NODC Accession 9700071)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Phytoplankton data were collected from net tows from the Ale Andro De Humboldt in the North Pacific Ocean from 08 January 1978 to 07 April 1978. Chlorophyll A and...

  17. Inequality in Participation in Adult Learning and Education (ALE): Effects of Micro- and Macro-Level Factors through a Comparative Study

    Science.gov (United States)

    Lee, Jeongwoo

    2017-01-01

    The objectives of this dissertation include describing and analyzing the patterns of inequality in ALE participation at both the micro and macro levels. Special attention is paid to social origins of individual adults and their association with two groups of macro-level factors, social inequality (income, education, and skill inequality) and…

  18. Sobre el uso de técnicas chopper para la reducción del ruido flicker en amplificadores para la captación de señales neuronales

    OpenAIRE

    Pérez Prieto, Norberto

    2016-01-01

    La captación de señales neuronales mediante electrodos conectados a circuitos micro-electrónicos es necesaria para aplicaciones clínicas y para el control de prótesis senso-motoras, entre otras muchas aplicaciones bio-médicas. En todas estas aplicaciones, la preservación de la información contenida en las imágenes captadas depende críticamente de las prestaciones de los amplificadores empleados en la cabecera de la cadena de procesamiento electrónica. El problema es que se trata de señales mu...

  19. Modeling Warm Dense Matter Experiments using the 3D ALE-AMR Code and the Move Toward Exascale Computing

    International Nuclear Information System (INIS)

    Koniges, A.; Eder, E.; Liu, W.; Barnard, J.; Friedman, A.; Logan, G.; Fisher, A.; Masers, N.; Bertozzi, A.

    2011-01-01

    The Neutralized Drift Compression Experiment II (NDCX II) is an induction accelerator planned for initial commissioning in 2012. The final design calls for a 3 MeV, Li+ ion beam, delivered in a bunch with characteristic pulse duration of 1 ns, and transverse dimension of order 1 mm. The NDCX II will be used in studies of material in the warm dense matter (WDM) regime, and ion beam/hydrodynamic coupling experiments relevant to heavy ion based inertial fusion energy. We discuss recent efforts to adapt the 3D ALE-AMR code to model WDM experiments on NDCX II. The code, which combines Arbitrary Lagrangian Eulerian (ALE) hydrodynamics with Adaptive Mesh Refinement (AMR), has physics models that include ion deposition, radiation hydrodynamics, thermal diffusion, anisotropic material strength with material time history, and advanced models for fragmentation. Experiments at NDCX-II will explore the process of bubble and droplet formation (two-phase expansion) of superheated metal solids using ion beams. Experiments at higher temperatures will explore equation of state and heavy ion fusion beam-to-target energy coupling efficiency. Ion beams allow precise control of local beam energy deposition providing uniform volumetric heating on a timescale shorter than that of hydrodynamic expansion. The ALE-AMR code does not have any export control restrictions and is currently running at the National Energy Research Scientific Computing Center (NERSC) at LBNL and has been shown to scale well to thousands of CPUs. New surface tension models that are being implemented and applied to WDM experiments. Some of the approaches use a diffuse interface surface tension model that is based on the advective Cahn-Hilliard equations, which allows for droplet breakup in divergent velocity fields without the need for imposed perturbations. Other methods require seeding or other methods for droplet breakup. We also briefly discuss the effects of the move to exascale computing and related

  20. Señalética como interfaz urbana: estudio de caso en Transmilenio - SITP, Bogotá

    OpenAIRE

    Chacón Chacón, Martha Estela

    2014-01-01

    Este trabajo desarrolla como idea central el rol de la señalética en Transmilenio como elemento fundamental en la relación funcional entre los sistemas de movilidad y de equipamentos planteada en el POT (2003), atendiendo al concepto de accesibilidad perceptual como articulador entre los dos sistemas. La investigación se desarrolló en tres niveles: el primer nivel desarrolla la base conceptual; el segundo nivel analiza documentos oficiales (POT 2003 y Plan Maestro de Movilidad), y bus...

  1. Weak beacon detection for air-to-ground optical wireless link establishment.

    Science.gov (United States)

    Han, Yaoqiang; Dang, Anhong; Tang, Junxiong; Guo, Hong

    2010-02-01

    In an air-to-ground free-space optical communication system, strong background interference seriously affects the beacon detection, which makes it difficult to establish the optical link. In this paper, we propose a correlation beacon detection scheme under strong background interference conditions. As opposed to traditional beacon detection schemes, the beacon is modulated by an m-sequence at the transmitting terminal with a digital differential matched filter (DDMF) array introduced at the receiving end to detect the modulated beacon. This scheme is capable of suppressing both strong interference and noise by correlation reception of the received image sequence. In addition, the DDMF array enables each pixel of the image sensor to have its own DDMF of the same structure to process its received image sequence in parallel, thus it makes fast beacon detection possible. Theoretical analysis and an outdoor experiment have been demonstrated and show that the proposed scheme can realize fast and effective beacon detection under strong background interference conditions. Consequently, the required beacon transmission power can also be reduced dramatically.

  2. An asymptotic preserving multidimensional ALE method for a system of two compressible flows coupled with friction

    Science.gov (United States)

    Del Pino, S.; Labourasse, E.; Morel, G.

    2018-06-01

    We present a multidimensional asymptotic preserving scheme for the approximation of a mixture of compressible flows. Fluids are modelled by two Euler systems of equations coupled with a friction term. The asymptotic preserving property is mandatory for this kind of model, to derive a scheme that behaves well in all regimes (i.e. whatever the friction parameter value is). The method we propose is defined in ALE coordinates, using a Lagrange plus remap approach. This imposes a multidimensional definition and analysis of the scheme.

  3. EFICIENTIZAREA OBŢINERII SEDIMENTELOR FURAJERE B12 -VITAMINIZATE DIN APE REZIDUALE AGROINDUSTRIALE: 2. MODIFICĂRI ALE UTILAJULUI

    Directory of Open Access Journals (Sweden)

    Victor COVALIOV

    2017-03-01

    Full Text Available Prin modificări constructive ale dispozitivelor bioreactorului şi soluţii noi: separarea zonelor acetogenă şi meta­no­genă în interiorul bioreactorului, recircularea CO2 şi suplimentarea acestuia cu H2 exogen, adsorbţia vitaminei B12 din lichidul postfermentare cu diatomită s-a obţinut ridicarea conţinutului de vitamina B12 în sedimentele epurării fermentativ–metanogene (anaerobe a borhotului postalcoolic până la calitatea de con­centrat furajer B12-vitaminizat, concomitent cu intensificarea producerii biometanului, ca elemente ale ridicării eficienţei ecologo-economice a epurării anaerobe a borhotului.MORE EFFICIENT PRODUCITON OF VITAMINIZED FORAGE SLUDGE CONTAINING B12 FROM AGRO-INDUSTRIAL WASTES: 2. EQUIPMENT MODIFICAITON The increase in vitamin B12 contents in the sludge was obtained resulted from the methanogenic (anaerobic digestion of post-distillery vinasse, through the design modifications of bioreactor interiour, CO2 re-circulation and its interaction with additionally dosed exogenic hydrogen. Vitamin B12 was further adsorbed on diatomite surface from the post-digestion liquid, which made it possible to produce the cattle forage concentrate enriched with vitamin B12. At the same time, biomethane production was intensified, being the element of ecologically-economic efficiency of anaerobic treatment of vinasse (agro-industrial waste.

  4. Modeling warm dense matter experiments using the 3D ALE-AMR code and the move toward exascale computing

    International Nuclear Information System (INIS)

    Koniges, A.; Liu, W.; Barnard, J.; Friedman, A.; Logan, G.; Eder, D.; Fisher, A.; Masters, N.; Bertozzi, A.

    2013-01-01

    The Neutralized Drift Compression Experiment II (NDCX II) is an induction accelerator planned for initial commissioning in 2012. The final design calls for a 3 MeV, Li + ion beam, delivered in a bunch with characteristic pulse duration of 1 ns, and transverse dimension of order 1 mm. The NDCX II will be used in studies of material in the warm dense matter (WDM) regime, and ion beam/hydrodynamic coupling experiments relevant to heavy ion based inertial fusion energy. We discuss recent efforts to adapt the 3D ALE-AMR code to model WDM experiments on NDCX II. The code, which combines Arbitrary Lagrangian Eulerian (ALE) hydrodynamics with Adaptive Mesh Refinement (AMR), has physics models that include ion deposition, radiation hydrodynamics, thermal diffusion, anisotropic material strength with material time history, and advanced models for fragmentation. Experiments at NDCX-II will explore the process of bubble and droplet formation (two-phase expansion) of superheated metal solids using ion beams. Experiments at higher temperatures will explore equation of state and heavy ion fusion beam-to-target energy coupling efficiency. Ion beams allow precise control of local beam energy deposition providing uniform volumetric heating on a timescale shorter than that of hydrodynamic expansion. We also briefly discuss the effects of the move to exascale computing and related computational changes on general modeling codes in fusion. (authors)

  5. Influence of provenance on physical and mechanical properties wood of Pinus tropicalis Morelet in Viñales. Pinar del Río. Cuba

    Directory of Open Access Journals (Sweden)

    Yarelys García García

    2013-12-01

    Full Text Available The overall objective of this paper is to analyze the effect of origin on the physical-mechanical Pinus tropicalis Morelet wood, with a view to providing the information necessary for their rational use properties. Five provenances were selected in the experimental plots at the Experimental Station of Viñales, where 10 trees were randomly selected to analyze the dendrometer following variables: diameter at 1.30 total height, crown diameter and crown height. In turn, at the height of 1.30 m a log of 50 cm in length for the study Densities, Total shrinkage in volume, radial contraction, Longitudinal, tangential and compression is obtained. The results obtained state that the origin is not a variable that has a marked influence on the physical - mechanical properties analyzed. Diameter 1.30 and crown diameter dendrometric variables are best levels of correlation present in relation to the properties of the wood examined. Considering the results obtained provenances La Jagua and Viñales must be very careful during drying and commissioning since they have a higher coefficient of anisotropy.

  6. Interfaz humano-computadora basada en señales de electrooculografía para personas con discapacidad motriz

    OpenAIRE

    Daniel Pacheco Bautista; Ignacio Algredo Badillo; David De la Rosa Mejía; Aurelio Horacio Heredia Jiménez

    2014-01-01

    En este trabajo se presenta el desarrollo de un prototipo que asiste, a personas con cierta discapacidad motriz, en la interacción con la computadora de una forma simple y económica, mediante señales de electrooculografía. Esta técnica permite detectar los movimientos oculares basada en el registro de la diferencia de potencial existente entre la córnea y la retina, tal propiedad es aprovechada en este proyecto para controlar el desplazamiento del cursor del ratón de una forma precisa sobre l...

  7. Integración de un sistema de neuroseñales para detectar expresiones en el análisis de material multimedia

    Directory of Open Access Journals (Sweden)

    Luz Ángela Moreno-Cueva

    2014-12-01

    Full Text Available Presenta los avances realizados en la integración de un dispositivo comercial de bajo costo para capturar neuroseñales, con el fin de registrar expresiones de un usuario de material multimedia. Todas las personas adoptan diversos tipos de expresiones al ver televisión, películas, comerciales u otros textos. Ejemplos de estas expresiones son: apretar los dientes en escenas de suspenso; mover la cabeza hacia atrás cuando se da la sensación de arrojar un objeto hacia fuera de la pantalla en películas 3D; desviar la mirada en las escenas de terror; sonreír en comerciales emotivos; dar carcajadas en escenas de humor, e incluso quedarse dormido por el desinterés. La idea general de este sistema es capturar todas estas expresiones en conjunto, con señales emotivas tales como el nivel de atención, frustración y meditación, para que los expertos en creación del material multimedia puedan realizar un análisis y mejorar sus productos. Se presentan pruebas experimentales que evidencian el buen funcionamiento del sistema.

  8. Drawing and writing: An ALE meta-analysis of sensorimotor activations.

    Science.gov (United States)

    Yuan, Ye; Brown, Steven

    2015-08-01

    Drawing and writing are the two major means of creating what are referred to as "images", namely visual patterns on flat surfaces. They share many sensorimotor processes related to visual guidance of hand movement, resulting in the formation of visual shapes associated with pictures and words. However, while the human capacity to draw is tens of thousands of years old, the capacity for writing is only a few thousand years old, and widespread literacy is quite recent. In order to compare the neural activations for drawing and writing, we conducted two activation likelihood estimation (ALE) meta-analyses for these two bodies of neuroimaging literature. The results showed strong overlap in the activation profiles, especially in motor areas (motor cortex, frontal eye fields, supplementary motor area, cerebellum, putamen) and several parts of the posterior parietal cortex. A distinction was found in the left posterior parietal cortex, with drawing showing a preference for a ventral region and writing a dorsal region. These results demonstrate that drawing and writing employ the same basic sensorimotor networks but that some differences exist in parietal areas involved in spatial processing. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Dynamic debonding in layered structures: a coupled ALE-cohesive approach

    Directory of Open Access Journals (Sweden)

    Marco Francesco Funari

    2017-07-01

    Full Text Available . A computational formulation able to simulate crack initiation and growth in layered structural systems is proposed. In order to identify the position of the onset interfacial defects and their dynamic debonding mechanisms, a moving mesh strategy, based on Arbitrary Lagrangian-Eulerian (ALE approach, is combined with a cohesive interface methodology, in which weak based moving connections are implemented by using a finite element formulation. The numerical formulation has been implemented by means of separate steps, concerned, at first, to identify the correct position of the crack onset and, subsequently, the growth by changing the computational geometry of the interfaces. In order to verify the accuracy and to validate the proposed methodology, comparisons with experimental and numerical results are developed. In particular, results, in terms of location and speed of the debonding front, obtained by the proposed model, are compared with the ones arising from the literature. Moreover, a parametric study in terms of geometrical characteristics of the layered structure are developed. The investigation reveals the impact of the stiffening of the reinforced strip and of adhesive thickness on the dynamic debonding mechanisms.

  10. COMPARATIVO DE LOS ALGORITMOS DE DIMENSIÓN FRACTAL HIGUCHI, KATZ Y MULTIRESOLUCIÓN DE CONTEO DE CAJAS EN SEÑALES EEG BASADAS EN POTENCIALES RELACIONADOS POR EVENTOS

    Directory of Open Access Journals (Sweden)

    Santiago Fernández Fraga

    Full Text Available La obtención de información por medio de la medición de señales registradas durante diferentes procesos o condiciones fisiológicas del cerebro es importante para poder desarrollar interfaces computacionales que traduzcan las señales eléctricas cerebrales a comandos computacionales de control. Un electroencefalograma (EEG registra la actividad eléctrica del cerebro en respuesta al recibir diferentes estímulos externos (potenciales por eventos. El análisis de estas señales permite identificar y distinguir estados específicos de la función fisiológica del cerebro. La Dimensión Fractal se ha utilizado como una herramienta para el análisis de formas de ondas biomédicas, en particular se ha utilizado para determinar la medida de la complejidad en series de tiempo generadas por EEG. El presente documento pretende analizar la base de datos HeadIT de series de tiempo biomédicas obtenidas por EEG a las cuales se obtendrán la FD por medio de los métodos Higuchi, Katz y Multi-resolución de Conteo de Cajas, que muestre la relación entre el método para la obtención de la Dimensión Fractal y la condición fisiológica de la señal basada en Potenciales Cerebrales Relacionados por Eventos.

  11. Different patterns and development characteristics of processing written logographic characters and alphabetic words: an ALE meta-analysis.

    Science.gov (United States)

    Zhu, Linlin; Nie, Yaoxin; Chang, Chunqi; Gao, Jia-Hong; Niu, Zhendong

    2014-06-01

    The neural systems for phonological processing of written language have been well identified now, while models based on these neural systems are different for different language systems or age groups. Although each of such models is mostly concordant across different experiments, the results are sensitive to the experiment design and intersubject variability. Activation likelihood estimation (ALE) meta-analysis can quantitatively synthesize the data from multiple studies and minimize the interstudy or intersubject differences. In this study, we performed two ALE meta-analysis experiments: one was to examine the neural activation patterns of the phonological processing of two different types of written languages and the other was to examine the development characteristics of such neural activation patterns based on both alphabetic language and logographic language data. The results of our first meta-analysis experiment were consistent with the meta-analysis which was based on the studies published before 2005. And there were new findings in our second meta-analysis experiment, where both adults and children groups showed great activation in the left frontal lobe, the left superior/middle temporal gyrus, and the bilateral middle/superior occipital gyrus. However, the activation of the left middle/inferior frontal gyrus was found increase with the development, and the activation was found decrease in the following areas: the right claustrum and inferior frontal gyrus, the left inferior/medial frontal gyrus, the left middle/superior temporal gyrus, the right cerebellum, and the bilateral fusiform gyrus. It seems that adults involve more phonological areas, whereas children involve more orthographic areas and semantic areas. Copyright © 2013 Wiley Periodicals, Inc.

  12. Validación de señales vibro-acústicas para el diagnóstico de fallas en rodamientos en un generador síncrono

    Directory of Open Access Journals (Sweden)

    Zulma Yadira Medrano Hurtado

    2017-01-01

    Full Text Available En este trabajo se describe el procedimiento y las herramientas utilizados en la medición y diagnóstico de señales de vibración capturadas a través de transductores de aceleración (acelerómetros piezoeléctricos y acústicos (micrófonos omnidireccionales. Además, se desarrolló un arreglo experimental empleando la metodología Taguchi para validar la información registrada de las señales de vibración para rodamientos sin falla y con falla artificial, respectivamente. La falla artificial consistió en una grieta producida en la jaula de un rodamiento SKF-6303-2RSH.Este método es no invasivo, ya que utiliza micrófonos para analizar la vibración, lo que representa no tener que montar ningún tipo de transductor en la máquina, además de ser sensible a fallas en la jaula.

  13. Establishing a link between vehicular PM sources and PM measurements in urban street canyons.

    Science.gov (United States)

    Eisner, Alfred D; Richmond-Bryant, Jennifer; Wiener, Russell W; Hahn, Intaek; Drake-Richman, Zora E; Ellenson, William D

    2009-12-01

    The Brooklyn Traffic Real-Time Ambient Pollutant Penetration and Environmental Dispersion (B-TRAPPED) study, conducted in Brooklyn, NY, USA, in 2005, was designed with multiple goals in mind, two of which were contaminant source characterization and street canyon transport and dispersion monitoring. In the portion of the study described here, synchronized wind velocity and azimuth as well as particulate matter (PM) concentrations at multiple locations along 33rd Street were used to determine the feasibility of using traffic emissions in a complex urban topography as a sole tracer for studying urban contaminant transport. We demonstrate in this paper that it is possible to link downwind concentrations of contaminants in an urban street canyon to the vehicular traffic cycle using Eigen-frequency analysis. In addition, multivariable circular histograms are used to establish directional frequency maxima for wind velocity and contaminant concentration.

  14. Parallel Dynamic Analysis of a Large-Scale Water Conveyance Tunnel under Seismic Excitation Using ALE Finite-Element Method

    Directory of Open Access Journals (Sweden)

    Xiaoqing Wang

    2016-01-01

    Full Text Available Parallel analyses about the dynamic responses of a large-scale water conveyance tunnel under seismic excitation are presented in this paper. A full three-dimensional numerical model considering the water-tunnel-soil coupling is established and adopted to investigate the tunnel’s dynamic responses. The movement and sloshing of the internal water are simulated using the multi-material Arbitrary Lagrangian Eulerian (ALE method. Nonlinear fluid–structure interaction (FSI between tunnel and inner water is treated by using the penalty method. Nonlinear soil-structure interaction (SSI between soil and tunnel is dealt with by using the surface to surface contact algorithm. To overcome computing power limitations and to deal with such a large-scale calculation, a parallel algorithm based on the modified recursive coordinate bisection (MRCB considering the balance of SSI and FSI loads is proposed and used. The whole simulation is accomplished on Dawning 5000 A using the proposed MRCB based parallel algorithm optimized to run on supercomputers. The simulation model and the proposed approaches are validated by comparison with the added mass method. Dynamic responses of the tunnel are analyzed and the parallelism is discussed. Besides, factors affecting the dynamic responses are investigated. Better speedup and parallel efficiency show the scalability of the parallel method and the analysis results can be used to aid in the design of water conveyance tunnels.

  15. ALE finite volume method for free-surface Bingham plastic fluids with general curvilinear coordinates

    International Nuclear Information System (INIS)

    Nagai, Katsuaki; Ushijima, Satoru

    2010-01-01

    A numerical prediction method has been proposed to predict Bingham plastic fluids with free-surface in a two-dimensional container. Since the linear relationships between stress tensors and strain rate tensors are not assumed for non-Newtonian fluids, the liquid motions are described with Cauchy momentum equations rather than Navier-Stokes equations. The profile of a liquid surface is represented with the two-dimensional curvilinear coordinates which are represented in each computational step on the basis of the arbitrary Lagrangian-Eulerian (ALE) method. Since the volumes of the fluid cells are transiently changed in the physical space, the geometric conservation law is applied to the finite volume discretizations. As a result, it has been shown that the present method enables us to predict reasonably the Bingham plastic fluids with free-surface in a container.

  16. ALE finite volume method for free-surface Bingham plastic fluids with general curvilinear coordinates

    Science.gov (United States)

    Nagai, Katsuaki; Ushijima, Satoru

    2010-06-01

    A numerical prediction method has been proposed to predict Bingham plastic fluids with free-surface in a two-dimensional container. Since the linear relationships between stress tensors and strain rate tensors are not assumed for non-Newtonian fluids, the liquid motions are described with Cauchy momentum equations rather than Navier-Stokes equations. The profile of a liquid surface is represented with the two-dimensional curvilinear coordinates which are represented in each computational step on the basis of the arbitrary Lagrangian-Eulerian (ALE) method. Since the volumes of the fluid cells are transiently changed in the physical space, the geometric conservation law is applied to the finite volume discretizations. As a result, it has been shown that the present method enables us to predict reasonably the Bingham plastic fluids with free-surface in a container.

  17. Estudio comparativo de técnicas de reducción de ruido en señales industriales mediante Transformada Wavelet Discreta y selección adaptativa del umbral

    Directory of Open Access Journals (Sweden)

    Antonio Cedeño Pozo Ing.,

    2013-04-01

    Full Text Available Résumén: Las técnicas de reducción de ruido son ampliamente utilizadas en la grabación de audio, la edición de imágenes y en el procesamiento de señales industriales. La idea es reconstruir los datos originales a partir de la señal ruidosa suprimiendo toda, o casi toda, la distorsión generada por el ruido inherente a los procesos físicos. En el presente trabajo se realiza una comparación de diferentes métodos de supresión de ruido que se basan en la selección adaptativa del umbral. Estas técnicas han sido usadas extensivamente en el procesamiento de imágenes pero el objetivo de este trabajo es evaluar su rendimiento en la reducción de ruido de señales industriales. En particular se analiza el comportamiento de los métodos Bayes Shrink, Normal Shrink, Modified Shrink y Neight Shrink para la reducción de ruido gaussiano en estas señales. A tales efectos se utilizó un conjunto de señales patrón, que incluye a las señales propuestas por Donoho y otras mediciones representativas obtenidas de procesos reales en las plantas de Níquel cubanas. Las pruebas realizadas revelan que el algoritmo Neigh Shrink es el que mejor se comporta en los datos analizados. Abstract: Noise reduction techniques are widely used for audio recording, image editing, and industrial signal processing. The idea is to reconstruct the original data from the noise-corrupted signal suppressing, all or almost all, the distortion caused by the inherent noise of the physical processes. In the present paper, we perform a comparative review of several noise reduction techniques based on adaptive threshold selection. These techniques have been extensively used for image processing. However, we aimed at evaluating their performance for industrial signal noise reduction. In particular, we analyze the behaviour of the Bayes Shrink, Normal Shrink, Modified Shrink, and Neight Shrink methods for the reduction of the

  18. Desarrollo de una interfaz gráfica, drivers y librerías para hardware de adquisición y generación de señales

    OpenAIRE

    Bernardino Perez, Daniel

    2012-01-01

    Projecte realitzat en col·laboració amb Sygnadyne Desarrollo de una interfaz gráfica en C++/Qt, drivers para windows (WDF) y librerías para hardware de adquisición y generación de señales basado en la plataforma PXI.

  19. Hierarchical material models for fragmentation modeling in NIF-ALE-AMR

    International Nuclear Information System (INIS)

    Fisher, A C; Masters, N D; Koniges, A E; Anderson, R W; Gunney, B T N; Wang, P; Becker, R; Dixit, P; Benson, D J

    2008-01-01

    Fragmentation is a fundamental process that naturally spans micro to macroscopic scales. Recent advances in algorithms, computer simulations, and hardware enable us to connect the continuum to microstructural regimes in a real simulation through a heterogeneous multiscale mathematical model. We apply this model to the problem of predicting how targets in the NIF chamber dismantle, so that optics and diagnostics can be protected from damage. The mechanics of the initial material fracture depend on the microscopic grain structure. In order to effectively simulate the fragmentation, this process must be modeled at the subgrain level with computationally expensive crystal plasticity models. However, there are not enough computational resources to model the entire NIF target at this microscopic scale. In order to accomplish these calculations, a hierarchical material model (HMM) is being developed. The HMM will allow fine-scale modeling of the initial fragmentation using computationally expensive crystal plasticity, while the elements at the mesoscale can use polycrystal models, and the macroscopic elements use analytical flow stress models. The HMM framework is built upon an adaptive mesh refinement (AMR) capability. We present progress in implementing the HMM in the NIF-ALE-AMR code. Additionally, we present test simulations relevant to NIF targets

  20. Hierarchical material models for fragmentation modeling in NIF-ALE-AMR

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, A C; Masters, N D; Koniges, A E; Anderson, R W; Gunney, B T N; Wang, P; Becker, R [Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551 (United States); Dixit, P; Benson, D J [University of California San Diego, 9500 Gilman Dr., La Jolla. CA 92093 (United States)], E-mail: fisher47@llnl.gov

    2008-05-15

    Fragmentation is a fundamental process that naturally spans micro to macroscopic scales. Recent advances in algorithms, computer simulations, and hardware enable us to connect the continuum to microstructural regimes in a real simulation through a heterogeneous multiscale mathematical model. We apply this model to the problem of predicting how targets in the NIF chamber dismantle, so that optics and diagnostics can be protected from damage. The mechanics of the initial material fracture depend on the microscopic grain structure. In order to effectively simulate the fragmentation, this process must be modeled at the subgrain level with computationally expensive crystal plasticity models. However, there are not enough computational resources to model the entire NIF target at this microscopic scale. In order to accomplish these calculations, a hierarchical material model (HMM) is being developed. The HMM will allow fine-scale modeling of the initial fragmentation using computationally expensive crystal plasticity, while the elements at the mesoscale can use polycrystal models, and the macroscopic elements use analytical flow stress models. The HMM framework is built upon an adaptive mesh refinement (AMR) capability. We present progress in implementing the HMM in the NIF-ALE-AMR code. Additionally, we present test simulations relevant to NIF targets.

  1. Non-invasive brain-to-brain interface (BBI: establishing functional links between two brains.

    Directory of Open Access Journals (Sweden)

    Seung-Schik Yoo

    Full Text Available Transcranial focused ultrasound (FUS is capable of modulating the neural activity of specific brain regions, with a potential role as a non-invasive computer-to-brain interface (CBI. In conjunction with the use of brain-to-computer interface (BCI techniques that translate brain function to generate computer commands, we investigated the feasibility of using the FUS-based CBI to non-invasively establish a functional link between the brains of different species (i.e. human and Sprague-Dawley rat, thus creating a brain-to-brain interface (BBI. The implementation was aimed to non-invasively translate the human volunteer's intention to stimulate a rat's brain motor area that is responsible for the tail movement. The volunteer initiated the intention by looking at a strobe light flicker on a computer display, and the degree of synchronization in the electroencephalographic steady-state-visual-evoked-potentials (SSVEP with respect to the strobe frequency was analyzed using a computer. Increased signal amplitude in the SSVEP, indicating the volunteer's intention, triggered the delivery of a burst-mode FUS (350 kHz ultrasound frequency, tone burst duration of 0.5 ms, pulse repetition frequency of 1 kHz, given for 300 msec duration to excite the motor area of an anesthetized rat transcranially. The successful excitation subsequently elicited the tail movement, which was detected by a motion sensor. The interface was achieved at 94.0±3.0% accuracy, with a time delay of 1.59±1.07 sec from the thought-initiation to the creation of the tail movement. Our results demonstrate the feasibility of a computer-mediated BBI that links central neural functions between two biological entities, which may confer unexplored opportunities in the study of neuroscience with potential implications for therapeutic applications.

  2. Childhood adverse life events, disordered eating, and body mass index in US Military service members.

    Science.gov (United States)

    Bakalar, Jennifer L; Barmine, Marissa; Druskin, Lindsay; Olsen, Cara H; Quinlan, Jeffrey; Sbrocco, Tracy; Tanofsky-Kraff, Marian

    2018-03-02

    US service members appear to be at high-risk for disordered eating. Further, the military is experiencing unprecedented prevalence of overweight and obesity. US service members also report a high prevalence of childhood adverse life event (ALE) exposure. Despite consistent links between early adversity with eating disorders and obesity, there is a dearth of research examining the association between ALE exposure and disordered eating and weight in military personnel. An online survey study was conducted in active duty personnel to examine childhood ALE history using the Life Stressor Checklist - Revised, disordered eating using the Eating Disorder Examination - Questionnaire total score, and self-reported body mass index (BMI, kg/m 2 ). Among 179 respondents, multiple indices of childhood ALE were positively associated with disordered eating. Traumatic childhood ALE and subjective impact of childhood ALE were associated with higher BMI and these associations were mediated by disordered eating. Findings support evaluating childhood ALE exposure among service members with disordered eating and weight concerns. Moreover, findings support the need for prospective research to elucidate these relationships. © 2018 Wiley Periodicals, Inc.

  3. Algoritmos Wavenet con Aplicaciones en la Aproximación de Señales: un Estudio Comparativo

    Directory of Open Access Journals (Sweden)

    C.R. Domínguez Mayorga

    2012-10-01

    Full Text Available Resumen: En este trabajo de investigación se aplican métodos adaptables en el diseño de algoritmos computacionales, dichos algoritmos emplean redes neuronales y series de wavelets para construir “neuroaproximadores” wavenets. Se muestra cómo las wavenets pueden combinarse con los métodos autosintonizables para obtener el seguimiento de señles complejas que están en función del tiempo. Los algoritmos obtenidos se aplican en la aproximación de señales que representan funciones algebraicas y funciones aleatorias, así como en una señal médica deun ECG. Se muestran los resultados en simulación numérica de dos arquitecturas de neuroaproximadores wavenets: el primero está basado en una wavenet, con el cual se aproximan las señales bajo estudio donde los parámetros de la red neuronal son ajustados en línea; el otro esquema emplea un filtro IIR a la salida de la red wavenet para discriminar las contribuciones de aquellas neuronas que tienen menos peso en la aproximación de la señal, lo que ayuda a reducir el tiempo de convergencia a un error mínimo deseado. Abstract: In this paper adaptable methods for computational algorithms are presented. These algorithms use neural networks and wavelet series to build neuro wavenets approximators. The algorithms obtained are applied to the approximation of signals that represent algebraic functions and random functions, as well as a medical EKG signal. It shows how wavenets can be combined with auto-tuning methods for tracking complex signals that are a function of time. Results are shown in numerical simulation of two architectures of neural approximators wavenets: the first is based on a wavenet with which they approach the signals under study where the parameters of the neural network are adjusted online, the other neuro approximator scheme uses an IIR filter to the output of wavenet, which serves to filter the out- put, in this way

  4. MANIFESTĂRI ALE CONFLICTULUI MUNCĂ-FAMILIE LA ANGAJAȚII DIN DOMENIUL PUBLIC/PRIVAT: DIMENSIUNI COMPARATIVE

    Directory of Open Access Journals (Sweden)

    Viorica ȘAITAN

    2018-03-01

    Full Text Available Una dintre preocupările constante ale cercetărilor organizaționale recente este legată de investigarea problematicii privind conflictul muncă-familie, ce apare ca urmare a incapacității persoanei de a integra în mod optim solicitările rolului familial şi cele ale rolului profesional, având preponderent drept consecințe stări emoționale, cognitive și comportamentale negative. Din această perspectivă, studiul de față prezintă rezultatele comparative privind felul în care este trăit conflictul muncă-familie la angajații din Republica Moldova (în total – 355 de subiecți, 184 de angajați în domeniul public și 171 de angajați în domeniul privat și consecințele acestuia la nivel afectiv (epuizare emoțională, cognitiv (percepția suportului organizațional și percepția satisfacției de viață și comportamental (angajamentul de rol, flexibilitate muncă-familie.MANIFESTATIONS OF THE WORK-FAMILY CONFLICT TO PUBLIC/PRIVATE EMPLOYEES: COMPARATIVE DIMENSIONSOne of the constant concerns of recent organizational research is related to the investigation of the problem of work-family conflict, which arises as a result of the inability of the person to optimally integrate the demands of the family role and those of the professional role, having mainly as a consequence of negative emotional, cognitive and behavioral states. From this perspective, the present study presents comparative results on the way in which the labor-family conflict is experienced by employees in the Republic of Moldova (total – 355 subjects, 184 employees in the public domain and 171 employees in the private domain and its consequences at the affective level (emotional exhaustion, cognitive level (the perception of the organizational support and the perception of life satisfaction and behavioral level (role commitment, work-family flexibility.

  5. Bound-Preserving Reconstruction of Tensor Quantities for Remap in ALE Fluid Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Klima, Matej [Czech Technical Univ. in Prague, Praha (Czech Republic); Kucharik, MIlan [Czech Technical Univ. in Prague, Praha (Czech Republic); Shashkov, Mikhail Jurievich [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Velechovsky, Jan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-06

    We analyze several new and existing approaches for limiting tensor quantities in the context of deviatoric stress remapping in an ALE numerical simulation of elastic flow. Remapping and limiting of the tensor component-by-component is shown to violate radial symmetry of derived variables such as elastic energy or force. Therefore, we have extended the symmetry-preserving Vector Image Polygon algorithm, originally designed for limiting vector variables. This limiter constrains the vector (in our case a vector of independent tensor components) within the convex hull formed by the vectors from surrounding cells – an equivalent of the discrete maximum principle in scalar variables. We compare this method with a limiter designed specifically for deviatoric stress limiting which aims to constrain the J2 invariant that is proportional to the specific elastic energy and scale the tensor accordingly. We also propose a method which involves remapping and limiting the J2 invariant independently using known scalar techniques. The deviatoric stress tensor is then scaled to match this remapped invariant, which guarantees conservation in terms of elastic energy.

  6. SISTEM INFORMATIC ADAPTIV „DETERMINAREA STĂRILOR PROPRII ALE MOLECULELOR DE FULLERENE”

    Directory of Open Access Journals (Sweden)

    Victor CIOBU

    2015-12-01

    Full Text Available În articol sunt studiate comportamentul şi proprietăţile fizice ale fullerenelor. Avantajul tehnologiilor informaţionale inteligente este de a construi automat programul de calcul din specificarea iniţială a problemei slab-structurate şi infor-maţiile de concretizare, furnizate de către beneficiarul problemei în cadrul dialogului cu SSD (parametrii necunoscuţi ai problemei, metoda de calcul, criteriile de optimizare etc.. SSD a fost folosit la cercetarea fullerenelor: C60, C70, C76, C82.ADAPTIVE INFORMATIC SYSTEM „DETERMINATION OF THE EIGENSTATES OF FULLERENE MOLECULES”In the present article the behavior and physical properties of fullerenes are studied. The advantage of intelligent information technologies is to build automatically computer program from the initial specification of a poorly-structured problem and the embodiment information provided by the recipient of the problem through a dialogue with DSS (unknown parameters of the problem, the method of calculation, optimization criteria etc.. DSS was used to research fullerene C60, C70, C76, C82.

  7. CONTRADICTORIALITATEA ÎN CORAPORT CU ALTE PRINCIPII ALE PROCESULUI PENAL

    Directory of Open Access Journals (Sweden)

    Lucia RUSU

    2016-03-01

    Full Text Available În legătură cu reformarea sistemului judiciar şi schimbările intervenite în viaţa social-politică a statului nostru, prin­cipiul contradictorialităţii a obţinut o nouă rezonanţă din considerentul că reforma judiciară şi de drept este legată direct de contradictorialitate. Reforma legii procesual penale trebuie să fie fundamentată pe o temelie teoretică solidă. Contra­dictorialitatea, însă, în calitate de noţiune juridică, este insuficient cercetată în doctrina dreptului procesual penal. La ziua de azi, specialişti notorii în domeniul dreptului procesual penal analizează şi studiază importanţa fundamentelor şi principiilor de bază ale procesului penal şi, în primul rând, contradictorialitatea acestuia. Legea procesual penală a Republicii Moldova cunoaşte o evoluţie şi dezvoltate în sensul democratizării şi lărgirii începuturilor contradictoriale în înfăptuirea justiţiei. Aceasta e şi firesc, deoarece contradictorialitatea are o importanţă enormă pentru întregul sistem al procesului penal, determinând în mare parte statutul juridic şi raporturile dintre participanţii la procesul penal, precum şi relaţiile juridice stabilite între participanţii la acest proces şi instanţa de judecată. CONTRADICTION AND ITS CORRELATION WITH OTHER PRINCIPLES OF THE CRIMINAL PROCEEDINGIn connection with the judiciary system reforming and changes in socio-political life of our state, the adversarial principle has gained a new resonance on the grounds that the judicial and legal reform is directly linked to adversariality. The reform of the criminal procedure law must be based on solid theoretical foundation. However, adversariality, as legal concept, is not enough investigated in the doctrine of the criminal procedure law. Currently, notorious specialists in the field of criminal procedure law examine and study the importance of fundamentals and basic principles of the criminal process and

  8. Meditation-related activations are modulated by the practices needed to obtain it and by the expertise: an ALE meta-analysis study

    Science.gov (United States)

    Tomasino, Barbara; Fregona, Sara; Skrap, Miran; Fabbro, Franco

    2013-01-01

    The brain network governing meditation has been studied using a variety of meditation practices and techniques practices eliciting different cognitive processes (e.g., silence, attention to own body, sense of joy, mantras, etc.). It is very possible that different practices of meditation are subserved by largely, if not entirely, disparate brain networks. This assumption was tested by conducting an activation likelihood estimation (ALE) meta-analysis of meditation neuroimaging studies, which assessed 150 activation foci from 24 experiments. Different ALE meta-analyses were carried out. One involved the subsets of studies involving meditation induced through exercising focused attention (FA). The network included clusters bilaterally in the medial gyrus, the left superior parietal lobe, the left insula and the right supramarginal gyrus (SMG). A second analysis addressed the studies involving meditation states induced by chanting or by repetition of words or phrases, known as “mantra.” This type of practice elicited a cluster of activity in the right SMG, the SMA bilaterally and the left postcentral gyrus. Furthermore, the last analyses addressed the effect of meditation experience (i.e., short- vs. long-term meditators). We found that frontal activation was present for short-term, as compared with long-term experience meditators, confirming that experts are better enabled to sustain attentional focus, rather recruiting the right SMG and concentrating on aspects involving disembodiment. PMID:23316154

  9. Meditation related activations are modulated by the practices needed to obtain it and by the expertise:an ALE meta-analysis study

    Directory of Open Access Journals (Sweden)

    Barbara eTomasino

    2013-01-01

    Full Text Available The brain network governing meditation has been studied using a variety of meditation practices and techniques practices eliciting different cognitive processes (e.g., silence, attention to own body, sense of joy, mantras, etc.. It is very possible that different practices of meditation are subserved by largely, if not entirely, disparate brain networks. This assumption was tested by conducting an activation likelihood estimation (ALE meta-analysis of meditation neuroimaging studies, which assessed 150 activation foci from 24 experiments. Different ALE meta-analyses were carried out. One involved the subsets of studies involving meditation induced through exercising focused attention. The network included clusters bilaterally in the medial gyrus, the left superior parietal lobe, the left insula and the right supramarginal gyrus. A second analysis addressed the studies involving meditation states induced by chanting or by repetition of words or phrases, known as ‘mantra’. This type of practice elicited a cluster of activity in the right supramarginal gyrus, the SMA bilaterally and the left postcentral gyrus. Furthermore, the last analyses addressed the effect of meditation experience (i.e., short- vs. long-term meditators. We found that frontal activation was present for short-term, as compared with long-term experience meditators, confirming that experts are better enabled to sustain attentional focus, rather recruiting the right supramarginal gyrus and concentrating on aspects involving disembodiment.

  10. INTERFAZ CEREBRO COMPUTADOR BASADO EN SEÑALES EEG PARA EL CONTROL DE MOVIMIENTO DE UNA PROTESIS DE MANO USANDO ANFIS

    Directory of Open Access Journals (Sweden)

    Alexandra Bedoya-Rojas

    2014-09-01

    Full Text Available Actualmente, existe un gran número de personas en el mundo que presentan amputación de miembros que son reemplazados usualmente por prótesis mecánicas. Por otro lado las prótesis electrómecanicas han venido tomando fuerza y son apoyadas por diferentes tipos de interfaces como las interfaces cerebro computador que han permitido mejorar la funcionalidad de estas, y a pesar de mostrar resultados representativos para el control de prótesis, aun es un campo abierto de investigación que busca mejorar su eficacia y eficiencia. En este estudio, se presenta una metodología de clasificación de señales electroencefalográficas (EEG para el control del movimiento de una prótesis de mano, basada en el sistema de inferencia neuro-difuso adaptativo (ANFIS aplicado a características obtenidas de la transformada wavelet (TW y los conjuntos difusos rough (FRS a señales EEG obtenidas en el sistema 10-10. De esta forma el rendimiento del sistema propuesto fue medido utilizando validación cruzada 70-30 con 30 repeticiones obteniendo un alto desempeño en términos de precisión, lo que significa que este modelo tiene potencial como clasificador en la detección de los cambios EEG para la generación de comandos para el control del movimiento de la mano

  11. Generador de Señales y Amplificador de Alto Voltaje para una Instalación de Medición del Lazo de Histéresis Ferroeléctrica

    Directory of Open Access Journals (Sweden)

    J. I. Benavides Benitez

    2011-03-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} El siguiente trabajo describe un generador de señales y un amplificador de alto voltaje usados para generar y amplificar las  señales necesarias para  una instalación de obtención del lazo de histéresis en muestras de materiales ferroeléctricos. Se describen también los programas desarrollados para controlar el generador desde la computadora con ayuda de un sistema de adquisición de datos.

  12. Reconocimiento de valvulopatías cardíacas en señales de fonocardiografía empleando la transformada Gabor

    OpenAIRE

    Echeverry Correa, Julián David; López, Andrés Felipe; López, Juan Fernando

    2007-01-01

    Se presenta en este trabajo una metodología de caracterización basada en la representación tiempo frecuencia de las señales fonocardiográficas con el fin de hacer reconocimiento de valvulopatías cardíacas. La naturaleza de estas patologías las hace susceptibles a ser caracterizadas por medio de representaciones en el espacio conjunto tiempo-frecuencia. Se emplea la transformada de Gabor para llevar los registros a este tipo bidimensional de representación. Los porcentajes de clasificación, me...

  13. Application of the 3D Iced-Ale method to equilibrium and stability problems of a magnetically confined plasma

    International Nuclear Information System (INIS)

    Barnes, D.C.; Brackbill, J.U.

    1977-01-01

    A numerical study of the equilibrium and stability properties of the Scyllac experiment at Los Alamos is described. The formulation of the numerical method, which is an extension of the ICED-ALE method to magnetohydrodynamic flow in three dimensions, is given. The properties of the method are discussed, including low computational diffusion, local conservation, and implicit formulation in the time variable. Also discussed are the problems encountered in applying boundary conditions and computing equilibria. The results of numerical computations of equilibria indicate that the helical field amplitudes must be doubled from their design values to produce equilibrium in the Scyllac experiment. This is consistent with other theoretical and experimental results

  14. Numismatic iconography over two evidences of sigillata hispanica from the roman town of Los Bañales (Uncastillo, Zaragoza

    Directory of Open Access Journals (Sweden)

    Javier Andreu Pintado

    2012-09-01

    Full Text Available The following paper presents two new evidences of hispanic sigillata from the roman city of Los Bañales (Uncastillo, Zaragoza, in the center of the Vascones area, that show decorations done with Marcus Aurelius’ coins. Both evidences are analyzed in the context of this habit in the spanish productions of pottery in Tricio firstable in Flavian times and then, briefly, during II century AD. The reflection goes, also, on a interpretative study of the phaenomenon testified in the hispanic sigillata in the first years of Marcus Aurelius and Lucius Verus’ reign offering a plausible explanation of its reasons.

  15. Micro-droplet based directed evolution outperforms conventional laboratory evolution

    DEFF Research Database (Denmark)

    Sjostrom, Staffan L.; Huang, Mingtao; Nielsen, Jens

    2014-01-01

    We present droplet adaptive laboratory evolution (DrALE), a directed evolution method used to improve industrial enzyme producing microorganisms for e.g. feedstock digestion. DrALE is based linking a desired phenotype to growth rate allowing only desired cells to proliferate. Single cells are con...... a whole-genome mutated library of yeast cells for α-amylase activity....

  16. Establishing the link between Ostreopsis cf.ovata blooms and human health impacts using ecology and epidemiology

    Directory of Open Access Journals (Sweden)

    Magda Vila

    2016-09-01

    Full Text Available Blooms of the benthic dinoflagellate Ostreopsis have been related to sporadic acute respiratory symptoms and general malaise in people exposed to marine aerosols on some Mediterranean beaches. However, the direct link between recurrent Ostreopsis blooms and health problems has not been clearly established. In order to establish and elucidate the connection, we conducted a joint ecology and epidemiology study in an Ostreopsis hot spot. Throughout the bloom, which extended from the end of June until the end of October 2013, 81% of the human cohort that we studied experienced at least one Ostreopsis-related symptom. Paradoxically, the time when the effects were greatest was during a short time window in early August. This corresponded to the transition from the exponential growth to the stationary phase of the bloom. Negligible symptoms were reported from August to mid-October, during the stationary period of the proliferation, when O. cf. ovata maintained high concentrations of epiphytic cells. No clear patterns in the landward wind component were noted during the time when health effects were greatest. Our main hypothesis is that the irritants present in the aerosol are produced during a particular physiological phase of the Ostreopsis cells during the bloom.

  17. Prueba chi-cuadrado y enfoque de señales como modelos de alerta temprana de crisis bancarias: aplicación al caso ecuatoriano

    OpenAIRE

    Rumbea Pavisic, Juan Francisco; Ayala Salcedo, Roberto Andres

    2009-01-01

    Este trabajo trata de modelar la crisis bancaria del Ecuador en 1995-1996. Para esto se analiza las situaciones específicas que diferencian a los bancos de otras empresas en una economía de mercado. Luego, se analiza la experiencia de la crisis. Finalmente se elabora un modelo de alerta temprana para la crisis bancaria de 1995-1996 basado en el enfoque de señales y prueba Chi-cuadrado.

  18. Nuevo Enfoque para la Clasificación de Señales EEG usando la Varianza de la Diferencia entre las Clases de un Clasificador Bayesiano

    Directory of Open Access Journals (Sweden)

    Thomaz R. Botelho

    2017-10-01

    Full Text Available Resumen: Los avances en robótica de rehabilitación están beneficiando en gran medida a los pacientes con discapacidad física. Los dispositivos de asistencia y rehabilitación pueden basar su funcionamiento en información fisiológica de los músculos y del cerebro a través de electromiografía (EMG y electroencefalografía (EEG, para detectar la intención de movimiento de los usuarios. En este trabajo se presenta una propuesta de interfaz multimodal para la adquisición, sincronización y procesamiento de señales EEG y de sensores inerciales, para ser aplicada en tareas de rehabilitación con exoesqueletos robóticos. Se realizaron experimentos con individuos sanos con el objetivo de analizar la intención de movimiento, la activación muscular e inicio de movimiento durante los movimientos de extensión de la rodilla. Esta propuesta es un nuevo enfoque para la clasificación de señales EEG usando un clasificador bayesiano tomando en cuenta la varianza de la diferencia entre las clases usadas. El aporte de este trabajo se sustenta con los resultados que muestran un incremento del 30% en la precisión de clasificación con señales EEG en comparación con los enfoques tradicionales de clasificación, en un análisis off-line para el reconocimiento de la intención de movimiento de los miembros inferiores. Abstract: Patients with physical disabilities can benefit from robotic rehabilitation. This improves the efficiency of recovery and, therefore, the rehabilitation of the patient. Assistive and rehabilitation devices can make use of physiological data, such as electromyography (EMG and electroencephalography (EEG, in order to detect movement intentions. This work presents a multimodal interface for signal acquisition, synchronization and processing of EEG and inertial sensors signals, to be applied in rehabilitation robotic exoskeletons. Experiments were performed with healthy individuals executing knee extension. The goal is to analyze

  19. Sistema de detección de señales de tráfico para la localización de intersecciones viales y frenado anticipado

    Directory of Open Access Journals (Sweden)

    Gabriel Villalón-Sepúlveda

    2017-04-01

    Full Text Available Resumen: En este trabajo se presenta un sistema de detección de señales de tráfico aledañas a intersecciones viales y rotondas, y un análisis para conocer su capacidad de detección en función de la distancia. El método propuesto está basado en la segmentación por color sobre el espacio RGB-normalizado (ErEgEb para la generación de regiones de interés (ROIs, la clasificación del tipo de señal usando los espacios YCbCr y ErEgEb para construir una plantilla estadística, donde para eliminar el fondo se ha propuesto una función de distribución de probabilidad que modeliza el color de los objetos de interés. El sistema está especializado en dos tipos de señales: disco Pare y triángulo invertido de Ceda el Paso. Luego se analiza su desempeño, al compararlo con el método de Viola & Jones, donde se verifica la capacidad de detección a diferentes distancias. Para distancias menores a 48 metros, el método propuesto ha logrado una tasa de detección del 87.5% en el caso de la señal de Ceda el Paso, y del 95.4% en el caso del disco Pare, mientras que para distancias inferiores a 30 metros la detección lograda es del 100%. Estos resultados son superiores a los reportados en la mayoría de la literatura existente, la cual a diferencia del presente trabajo no aborda la sensibilidad de los métodos propuestos ante la variación de la distancia a las señales de tráfico aún cuando esto es uno de los principales desafíos en la implementación de sistemas de asistencia al conductor aplicables al mundo real. Los experimentos han sido desarrollados sobre una base de datos de señales de tráfico, generadas a partir de imágenes tomadas en varias calles de la ciudad de Santiago, Región Metropolitana, Chile, usando un vehículo experimental diseñado para desarrollar sistemas inteligentes. Abstract: This paper describes a system for traffic sign detection from surrounding traffic intersections and analysis for the ability of detection

  20. Spent Fuel Ratio Estimates from Numerical Models in ALE3D

    Energy Technology Data Exchange (ETDEWEB)

    Margraf, J. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dunn, T. A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-08-02

    Potential threat of intentional sabotage of spent nuclear fuel storage facilities is of significant importance to national security. Paramount is the study of focused energy attacks on these materials and the potential release of aerosolized hazardous particulates into the environment. Depleted uranium oxide (DUO2) is often chosen as a surrogate material for testing due to the unreasonable cost and safety demands for conducting full-scale tests with real spent nuclear fuel. To account for differences in mechanical response resulting in changes to particle distribution it is necessary to scale the DUO2 results to get a proper measure for spent fuel. This is accomplished with the spent fuel ratio (SFR), the ratio of respirable aerosol mass released due to identical damage conditions between a spent fuel and a surrogate material like depleted uranium oxide (DUO2). A very limited number of full-scale experiments have been carried out to capture this data, and the oft-questioned validity of the results typically leads to overly-conservative risk estimates. In the present work, the ALE3D hydrocode is used to simulate DUO2 and spent nuclear fuel pellets impacted by metal jets. The results demonstrate an alternative approach to estimate the respirable release fraction of fragmented nuclear fuel.

  1. Study of variability in a virtual wedges A.L.E. Primus, measured weekly, for two years; Estudio de la variabilidad de las cunas virtuales en un A. L. E. Primus, medidas semanalmente, dure dos anos

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Segovia, J.; Ruiz Vazquez, M.; Carrera Magarino, F.

    2011-07-01

    We try to analyze the stability of virtual wedges in the daily control of an electron linear accelerator (ALE), measuring weekly each wedge angle and for the two photon energies available on the machine.

  2. The neural basis of kinesthetic and visual imagery in sports: an ALE meta - analysis.

    Science.gov (United States)

    Filgueiras, Alberto; Quintas Conde, Erick Francisco; Hall, Craig R

    2017-12-19

    Imagery is a widely spread technique in the sport sciences that entails the mental rehearsal of a given situation to improve an athlete's learning, performance and motivation. Two modalities of imagery are reported to tap into distinct brain structures, but sharing common components: kinesthetic and visual imagery. This study aimed to investigate the neural basis of those types of imagery with Activation Likelihood Estimation algorithm to perform a meta - analysis. A systematic search was used to retrieve only experimental studies with athletes or sportspersons. Altogether, nine studies were selected and an ALE meta - analysis was performed. Results indicated significant activation of the premotor, somatosensory cortex, supplementary motor areas, inferior and superior parietal lobule, caudate, cingulate and cerebellum in both imagery tasks. It was concluded that visual and kinesthetic imagery share similar neural networks which suggests that combined interventions are beneficial to athletes whereas separate use of those two modalities of imagery may seem less efficient from a neuropsychological approach.

  3. ‘Quadrilateral’ in Philosophy and Bie-modernism (Comments on Aleš Erjavec’s “Zhuyi: From Absence to Bustle? Some Comments on Wang Jianjiang's Article ‘The Bustle and the Absence of Zhuyi’”

    Directory of Open Access Journals (Sweden)

    Wang Jianjiang

    2017-09-01

    Full Text Available Aleš Erjavec proposed the global philosophical quadrilateral, giving Chinese philosophy, aesthetics, and humanities an expectation. However, the realization of this expectation hinges on the question whether Chinese philosophy as well as aesthetics and the humanities can rid themselves of the staggering level of ‘voice’ and develop their ‘speech’. To make ‘speech’, any nation should have its own idea, theory and Zhuyi. How to overcome the embarrassment that ‘quadrilateral’ expectation implies? Time spatialization and four-phase development theories of the Bie-modern, and great leap forward pause theory have provided an answer. The quadrilateral expectation as shown by Aleš Erjavec, is encountering the antagonism between ‘cosmopolitanism’ and ‘nationalism’. The key to resolving this antagonism is ‘my’ original achievement consisting of ‘Chinese traditional philosophy, Western philosophy, Marxism and I (myself’. Bie-modernism is a Zhuyi of self-regulation, self-renewal and self-transcendence and of their practical implementation.   Article received: May 21, 2017; Article accepted: May 24, 2017; Original scholarly paper How to cite this article: Jianjiang, Wang. "‘Quadrilateral’ in Philosophy and Bie-modernism (Comments on Aleš Erjavec’s “Zhuyi: From Absence to Bustle? Some Comments on Wang Jianjiang's Article ‘The Bustle and the Absence of Zhuyi’”." AM Journal of Art and Media Studies 13 (2017: 123-142. doi: 10.25038/am.v0i13.190

  4. Diseño de una matriz de conmutación 8:1 para señales de microondas en banda X.

    OpenAIRE

    DRAGOMIR, ALIN OVIDIU

    2016-01-01

    En el presente trabajo se aborda el diseño, fabricación y validación experimental de una matriz de conmutación de 8 canales para la medida de señales de microondas. Para la realización de una implementación compacta y con elevados tiempos de conmutación, se ha optado por una implementación en tecnología de circuitos impresos (PCB) empleando switches de RF en tecnolotgía Ultra-CMOS. El dispositivo propuesto tendría múltiples aplicaciones, entre las que cabe destacar (dado que se encuentra en e...

  5. Application of cyclic fluorocarbon/argon discharges to device patterning

    International Nuclear Information System (INIS)

    Metzler, Dominik; Uppireddi, Kishore; Bruce, Robert L.; Miyazoe, Hiroyuki; Zhu, Yu; Price, William; Sikorski, Ed S.; Engelmann, Sebastian U.; Joseph, Eric A.; Li, Chen; Oehrlein, Gottlieb S.

    2016-01-01

    With increasing demands on device patterning to achieve smaller critical dimensions and pitches for the 5 nm node and beyond, the need for atomic layer etching (ALE) is steadily increasing. In this work, a cyclic fluorocarbon/Ar plasma is successfully used for ALE patterning in a manufacturing scale reactor. Self-limited etching of silicon oxide is observed. The impact of various process parameters on the etch performance is established. The substrate temperature has been shown to play an especially significant role, with lower temperatures leading to higher selectivity and lower etch rates, but worse pattern fidelity. The cyclic ALE approach established with this work is shown to have great potential for small scale device patterning, showing self-limited etching, improved uniformity and resist mask performance

  6. Application of cyclic fluorocarbon/argon discharges to device patterning

    Energy Technology Data Exchange (ETDEWEB)

    Metzler, Dominik, E-mail: dmetzler@umd.edu [IBM T. J. Watson Research Center, Yorktown Heights, New York 10598 and Department of Materials Science and Engineering, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States); Uppireddi, Kishore; Bruce, Robert L.; Miyazoe, Hiroyuki; Zhu, Yu; Price, William; Sikorski, Ed S.; Engelmann, Sebastian U.; Joseph, Eric A. [IBM T. J. Watson Research Center, Yorktown Heights, New York 10598 (United States); Li, Chen [Department of Physics, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States); Oehrlein, Gottlieb S. [Department of Materials Science and Engineering, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States)

    2016-01-15

    With increasing demands on device patterning to achieve smaller critical dimensions and pitches for the 5 nm node and beyond, the need for atomic layer etching (ALE) is steadily increasing. In this work, a cyclic fluorocarbon/Ar plasma is successfully used for ALE patterning in a manufacturing scale reactor. Self-limited etching of silicon oxide is observed. The impact of various process parameters on the etch performance is established. The substrate temperature has been shown to play an especially significant role, with lower temperatures leading to higher selectivity and lower etch rates, but worse pattern fidelity. The cyclic ALE approach established with this work is shown to have great potential for small scale device patterning, showing self-limited etching, improved uniformity and resist mask performance.

  7. Adquisición, registro y transmisión en tiempo real de señales sismológicas bajo TCP/IP

    Directory of Open Access Journals (Sweden)

    Vargas-jiménez Carlos A.

    2001-08-01

    Full Text Available

    The constant evolution of network technologies has made possible the development of applications facilitating the real time access to the information. This way, it is possible the implementation of remote monitoring systems that using PCs achieves efficient transmission of signals through computer networks. In this work, the procedures system design and implementation procedures are explain in Client/Server environment that, based on TCP/lP, transmits in real time 16 seismological signals over LAN network and the Internet. The server is a PC endowed with an acquisition data card and it is the one in charge of carrying out the signal Analog/Digital conversion, to store in files those that correspond to seismic events and, at the same time, to assist the applications of the different clients. The client's software allows the users to view in real time the signals that the server is acquiring and to carry out a basicn processing to the signals that have been registered in the server.

    Se presenta el desarrollo de un sistema de monitoreo de variables sísmicas, que incluye la adquisición y adecuación de 16 canales simultáneos, el preproceso, la grabación y la transmisión sobre redes IP en tiempo real. EI sistema esta orientado al sistema Windows, para lo cual se emplearon librerías dinámicas orientadas al acceso de dispositivos en tiempo real. Así mismo, el acceso de datos al PC se realiza vfa DMA, para implementar el proceso múltiple de señales en tiempo real. La arquitectura de la red IP de monitoreo sísmico es cliente/servidor, en la cual se tome como servidor un PC dotado de una tarjeta de adquisición de datos, encargado de realizar la conversión an

  8. +2.71 LOD score at zero recombination is not sufficient for establishing linkage between X-linked mental retardation and X-chromosome markers

    Energy Technology Data Exchange (ETDEWEB)

    Robledo, R.; Melis, P.; Siniscalco, M. [and others

    1996-07-12

    Nonspecific X-linked mental retardation (MRX) is the denomination attributed to the familial type of mental retardation compatible with X-linked inheritance but lacking specific phenotypic manifestations. It is thus to be expected that families falling under such broad definition are genetically heterogeneous in the sense that they may be due to different types of mutations occurring, most probably, at distinct X-chromosome loci. To facilitate a genetic classification of these conditions, the Nomenclature Committee of the Eleventh Human Gene Mapping Workshop proposed to assign a unique MRX-serial number to each family where evidence of linkage with one or more X-chromosome markers had been established with a LOD score of at least +2 at zero recombination. This letter is meant to emphasize the inadequacy of this criterion for a large pedigree where the segregation of the disease has been evaluated against the haplotype constitution of the entire X-chromosome carrying the mutation in question. 12 refs., 2 figs., 1 tab.

  9. Caries assessment: establishing mathematical link of clinical and benchtop method

    Science.gov (United States)

    Amaechi, Bennett T.

    2009-02-01

    It is well established that the development of new technologies for early detection and quantitative monitoring of dental caries at its early stage could provide health and economic benefits ranging from timely preventive interventions to reduction of the time required for clinical trials of anti-caries agents. However, the new technologies currently used in clinical setting cannot assess and monitor caries using the actual mineral concentration within the lesion, while a laboratory-based microcomputed tomography (MCT) has been shown to possess this capability. Thus we envision the establishment of mathematical equations relating the measurements of each of the clinical technologies to that of MCT will enable the mineral concentration of lesions detected and assessed in clinical practice to be extrapolated from the equation, and this will facilitate preventitive care in dentistry to lower treatment cost. We utilize MCT and the two prominent clinical caries assessment devices (Quantitative Light-induced Fluorescence [QLF] and Diagnodent) to longitudinally monitor the development of caries in a continuous flow mixed-organisms biofilm model (artificial mouth), and then used the collected data to establish mathematical equation relating the measurements of each of the clinical technologies to that of MCT. A linear correlation was observed between the measurements of MicroCT and that of QLF and Diagnodent. Thus mineral density in a carious lesion detected and measured using QLF or Diagnodent can be extrapolated using the developed equation. This highlights the usefulness of MCT for monitoring the progress of an early caries being treated with therapeutic agents in clinical practice or trials.

  10. ELEMENTELE CONSTITUTIVE ŞI ELEMENTELE CIRCUMSTANŢIALE AGRAVANTE ALE INFRACŢIUNILOR CONTRA PATRIMONIULUI MILITAR

    Directory of Open Access Journals (Sweden)

    Sergiu BRÎNZA

    2016-11-01

    Full Text Available Articolul de faţă este dedicat analizei juridico-penale a infracţiunilor contra patrimoniului militar, prevăzute laart.379-381 CP RM. Sunt examinate elementele constitutive (obiectul, latura obiectivă, latura subiectivă şi subiectul,precum şi elementele circumstanţiale agravante ale acestor infracţiuni. Sunt propuse criterii de delimitare a infracţiunilorspecificate la art.379-381 CP RM în raport cu faptele conexe de factură penală sau nepenală. Printre aspectele de noutateale studiului de faţă trebuie remarcată revizuirea concepţiei de identificare a variantelor-tip şi a variantelor agravate în cazulinfracţiunilor prevăzute la art.379 CP RM. În rezultatul analizei efectuate se ajunge la concluzia că, datorită specificului lor,infracţiunile contra patrimoniului militar nu au victimă. De asemenea, se stabileşte că infracţiunile prevăzute la art.379-381CP RM sunt săvârşite pe calea acţiunii (şi sau inacţiunii. Se arată că, de cele mai dese ori, infracţiunile contra patrimoniului militar au o factură materială. Doar în situaţia infracţiunii prevăzute la alin.(1 art.381 CP RM se atestă existenţa semnelor atât ale unei infracţiuni materiale, cât şi ale unei infracţiuni formale. Se relevă că timpul de război este un semn secundarobligatoriu al laturii obiective în ipoteza infracţiunilor specificate la lit.a alin.(3 art.379, lit.a alin.(2 art.380, lit.a alin.(2şi lit.a alin.(4 art.381 CP RM. Se stabileşte că ambianţa infracţiunii (şi anume – condiţiile de luptă constituie un semnsecundar obligatoriu al laturii obiective în cazul infracţiunilor prevăzute la lit.b alin.(3 art.379, lit.b alin.(2 art.380, lit.balin.(2 şi lit.b alin.(4 art.381 CP RM. Se arată că infracţiunea specificată la art.380 CP RM este săvârşită din imprudenţă.În situaţii de altă natură, făptuitorul manifestă intenţie sau imprudenţă faţă de fapta prejudiciabilă şi numai impruden

  11. Diseño y construcción de un prototipo de electroencefalógrafo para adquisición de señales cerebrales

    OpenAIRE

    Villalba Calvillo, Guillermo

    2016-01-01

    El objetivo del presente proyecto es el desarrollo e implementación de un electroencefalógrafo de pequeñas dimensiones que permita la monitorización y registro de señales cerebrales. El sistema estará compuesto por una etapa analógica que se encargará de acondicionar la señal, una etapa digital, compuesta por un microcontrolador (DAQ) cuyo objetivo es digitalizar la señal que recibe de la etapa analógica, y una interfaz gráfica para visualizar dicha señal, donde se podrá procesar y analizar l...

  12. Comunicación con computador mediante señales cerebrales : aplicación a la tecnología de la rehabilitación

    OpenAIRE

    Martínez Pérez, Jose Luis

    2011-01-01

    Avances recientes en hardware para ordenadores personales y procesamiento de señal ha hecho posible el uso de señales EEG u ondas cerebrales para comunicación entre personas y computadores. Pacientes que sufren de síndromes bloqueantes disponen ahora de una nueva forma de comunicación con el resto del mundo, pero incluso con las más modernas técnicas, estos sistemas aún tienen tasas de comunicación del orden de 2-3 actividades / minuto. En suma, los dispositivos existentes no son diseñados co...

  13. Comunicación con computador mediante señales cerebrales : aplicación a la tecnología de la rehabilitación

    OpenAIRE

    Martínez Pérez, Jose Luis

    2010-01-01

    Avances recientes en hardware para ordenadores personales y procesamiento de señal ha hecho posible el uso de señales EEG u ondas cerebrales para comunicación entre personas y computadores. Pacientes que sufren de síndromes bloqueantes disponen ahora de una nueva forma de comunicación con el resto del mundo, pero incluso con las más modernas técnicas, estos sistemas aún tienen tasas de comunicación del orden de 2-3 actividades / minuto. En suma, los dispositivos existentes no son diseñados co...

  14. Evaluación del uso de señales visuales y de localización por el colibrí cola-ancha (Selasphorus platycercus al visitar flores de Penstemon roseus Evaluation of the use of visual and location cues by the Broad-tailed hummingbird (Selasphorus platycercusforaging in flowers of Penstemon roseus

    Directory of Open Access Journals (Sweden)

    Guillermo Pérez

    2012-03-01

    Full Text Available En los colibríes la memoria espacial desempeña un papel importante durante el forrajeo. Éste se basa en el uso de señales específicas (visuales o en señales espaciales (localización de flores y plantas con néctar. Sin embargo, el uso de estas señales por los colibríes puede variar de acuerdo con la escala espacial que enfrentan cuando visitan flores de una o más plantas durante el forrajeo; ésto se puso a prueba con individuos del colibrí cola-ancha Selasphorus platycercus. Por otro lado, para evaluar la posible variación en el uso de las señales, se llevaron a cabo experimentos en condiciones semi-naturales utilizando flores de la planta Penstemon roseus, nativa del sitio de estudio. A través de la manipulación de la presencia/ausencia de una recompensa (néctar y señales visuales, evaluamos el uso de la memoria espacial durante el forrajeo entre 2 plantas (experimento 1 y dentro de una sola planta (experimento 2. Los resultados demostraron que los colibríes utilizaron la memoria de localización de la planta de cuyas flores obtuvieron recompensa, independientemente de la presencia de señales visuales. Por el contrario, en flores individuales de una sola planta, después de un corto periodo de aprendizaje los colibríes pueden utilizar las señales visuales para guiar su forrajeo y discriminar las flores sin recompensa. Asimismo, en ausencia de señales visuales los individuos basaron su forrajeo en la memoria de localización de la flor con recompensa visitada previamente. Estos resultados sugieren plasticidad en el comportamiento de forrajeo de los colibríes influenciada por la escala espacial y por la información adquirida en visitas previas.In hummingbirds spatial memory plays an important role during foraging. It is based in use of specific cues (visual or spatial cues (location of flowers and plants with nectar. However, use of these cues by hummingbirds may change according to the spatial scale they face when visit

  15. L'endométriose périnéale profonde sur cicatrice d’épisiotomie: à propos d'un cas rare

    OpenAIRE

    Laadioui, Meriem; Alaoui, Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Aabdelilah

    2013-01-01

    Parmi les localisations rares de l'endométriose sur cicatrice, celle du périnée demeure exceptionnelle, l'origine en est souvent iatrogène (épisiotomie). Nous rapportons le cas d'une patiente présentant une douleur cyclique, au niveau de la cicatrice d’épisiotomie. Avec à l'examen clinique une masse de 3,5 cm de grand diamètre au niveau de la cicatrice d’épisiotomie. L’écho périnéale a objectivé une image hypoéchgène hétérogène non vascularisée en regard de la cicatrice d’épisiotomie faisant ...

  16. The probability factor in establishing causation

    International Nuclear Information System (INIS)

    Hebert, J.

    1988-01-01

    This paper discusses the possibilities and limitations of methods using the probability factor in establishing the causal link between bodily injury, whether immediate or delayed, and the nuclear incident presumed to have caused it (NEA) [fr

  17. Establishing a communications link between two different, incompatible, personal computers: with practical examples and illustrations and program code.

    Science.gov (United States)

    Davidson, R W

    1985-01-01

    The increasing need to communicate to exchange data can be handled by personal microcomputers. The necessity for the transference of information stored in one type of personal computer to another type of personal computer is often encountered in the process of integrating multiple sources of information stored in different and incompatible computers in Medical Research and Practice. A practical example is demonstrated with two relatively inexpensive commonly used computers, the IBM PC jr. and the Apple IIe. The basic input/output (I/O) interface chip for serial communication for each computer are joined together using a Null connector and cable to form a communications link. Using BASIC (Beginner's All-purpose Symbolic Instruction Code) Computer Language and the Disk Operating System (DOS) the communications handshaking protocol and file transfer is established between the two computers. The BASIC programming languages used are Applesoft (Apple Personal Computer) and PC BASIC (IBM Personal computer).

  18. Linked data meets ontology matching: enhancing data linking through ontology alignments

    OpenAIRE

    Scharffe , François; Euzenat , Jérôme

    2011-01-01

    scharffe2011b; International audience; The Web of data consists of publishing data on the Web in such a way that they can be connected together and interpreted. It is thus critical to establish links between these data, both for the Web of data and for the Semantic Web that it contributes to feed. We consider here the various techniques which have been developed for that purpose and analyze their commonalities and differences. This provides a general framework that the diverse data linking sy...

  19. Análisis acústico sobre señales de auscultación digital para la detección de soplos cardíacos

    OpenAIRE

    CASTAÑO, ANDRÉS M.; DELGADO T., EDILSON; GODINO, JUANI; CASTELLANOS, GERMÁN

    2009-01-01

    Se presenta la metodología basada en el análisis acústico de señales fonocardiográficas (FCG) par a detectar soplos cardíacos. En primer lugar se desarrolla un sistema de filtración basado en la transformada wavelet para reducir las perturbaciones que usualmente se presentan en la etapa de adquisición, ajustando la calidad del sonido de acuerdo a los requerimientos clínicos y validados por especialistas en semiología. Se propone un algoritmo de segmentación basado en la energía promedio norm...

  20. Investigation of volcanic gas analyses and magma outgassing from Erta' Ale lava lake, Afar, Ethiopia

    Energy Technology Data Exchange (ETDEWEB)

    Gerlach, T.M.

    1980-05-01

    The analyses of 18 volcanic gas samples collected over a two-hour period at 1075/sup 0/C from Erta' Ale lava lake in December 1971 and of 18 samples taken over a half-hour period at 1125 to 1135/sup 0/C in 1974 display moderately to intensely variable compositions. These variations result from imposed modifications caused by (1) atmospheric contamination and oxidation, (2) condensation and re-evaporation of water during collection, (3) analytical errors, and (4) chemical reactions between the erupted gases and a steel lead-in tube. Detailed examinations of the analyses indicate the erupted gases were at chemical equilibrium before collection. This condition was partially destroyed by the imposed modifications. High-temperature reaction equilibria were more completely preserved in the 1974 samples. Numerical procedures based on thermodynamic calculations have been used to restore each analysis to a composition representative of the erupted gases. These procedures have also been used to restore the anhydrous mean compositions reported for two series of collections taken at the lava lake in January 1973.

  1. Effect of Low-Magnitude Whole-Body Vibration Combined with Alendronate in Ovariectomized Rats: A Random Controlled Osteoporosis Prevention Study

    Science.gov (United States)

    Zhong, Zhao-Ming; Wu, Xiu-Hua; Huang, Zhi-Ping; Li, Wei; Ding, Ruo-Ting; Yu, Hui; Chen, Jian-Ting

    2014-01-01

    Background Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats. Methods A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+WBV+ALE). The level of WBV applied was 0.3 g at 45–55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and μCT analysis. Results Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12.Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups. Conclusions Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture. PMID:24796785

  2. Estudio de técnicas de análisis y clasificación de señales EEG en el contexto de sistemas BCI (Brain Computer Interface)

    OpenAIRE

    Henríquez Muñoz, Claudia Nureibis

    2014-01-01

    Máster universitario en Investigación e Innovación en TIC. Las Interfaces Cerebro Computador (BCI) son una tecnología basada en la adquisición y procesamiento de señales cerebrales para el control de diversos dispositivos. Su objetivo principal es proporcionar un nuevo canal de salida al cerebro del usuario que requiere un control adaptativo voluntario. Usualmente los BCI se enfocan en reconocer eventos que son adquiridos por métodos como el Electroencefalograma (EEG). Dicho...

  3. [Autism spectrum disorder and evaluation of perceived stress parents and professionals: Study of the psychometric properties of a French adaptation of the Appraisal of Life Event Scale (ALES-vf)].

    Science.gov (United States)

    Cappe, É; Poirier, N; Boujut, É; Nader-Grosbois, N; Dionne, C; Boulard, A

    2017-08-01

    Autism and related disorders are grouped into the category of « Autism Spectrum Disorder » (ASD) in the DSM-5. This appellation reflects the idea of a dimensional representation of autism that combines symptoms and characteristics that vary in severity and intensity. Despite common characteristics, there are varying degrees in intensity and in the onset of symptoms, ranging from a disability that can be very heavy with a total lack of communication and major disorders associated with the existence of a relative autonomy associated, sometimes, with extraordinary intellectual abilities. Parents are faced with several difficult situations, such as sleep disturbances, agitation, shouting, hetero violence, self-harm, learning difficulties, stereotyping, lack of social and emotional reciprocity, inappropriate behavior, etc. They can feel helpless and may experience stress related to these developmental and behavioral difficulties. The heterogeneity of symptoms, the presence of behavioral problems, the lack of reciprocity and autonomy also represent a challenge for practitioners in institutions and teachers at school. The objective of this research is to present the validation of a French translation of the Appraisal of Life Events Scale (ALES-vf) from Ferguson, Matthex and Cox, specifically adapted to the context of ASD. ALES was originally developed to operationalize the three dimensions of perceived stress (threat, loss and challenge) described by Lazarus and Folkman. ALES-vf was initially translated into French and adapted to the situation of parents of children with ASD. It was subsequently administered to 343 parents, 150 paramedical professionals involved with people with ASD, and 155 teachers from an ordinary school environment and from specialized schools, welcoming in their classroom at least one child with ASD. An exploratory factor analysis performed on data from 170 parents highlighted two exploratory models with four and three factors, slightly different

  4. Dramaturgia wiersza: „wiersz-płacz”. Płakała w nocy, ale nie jej płacz go zbudził

    Directory of Open Access Journals (Sweden)

    Anna Krajewska

    2016-12-01

    Full Text Available The article is an interpretation of the poem “Płakała w nocy, ale nie jej płacz go zbudził” (“She cried at night, but not her cries woke him” written by Stanisław Barańczak. The author focuses on description in this poem – dramatic in shape, philosophical, and according to the narrative of the anthropocentrism crisis. The author considers this poem to be a metaphysical text defining the relationship between the world of human and non-human reality. She compares the poem with those written by Jan Kochanowski (Laments, Cyprian Kamil Norwid (In Verona, Andrew Marvell (Eyes and tears, Szymborska (Apple tree.

  5. Señales de valor de marca de las franquicias en México. Su efecto en el crecimiento del sistema franquiciador

    Directory of Open Access Journals (Sweden)

    Jannett Ayup-González

    2014-04-01

    Full Text Available La valoración de marca en la franquicia es aún insuficiente. Estos negocios estimulan el desarrollo económico de los países emergentes como México. El propósito de este trabajo es analizar las señales de valor de las marcas de franquicias que impulsaron el crecimiento de establecimientos de 2002 a 2008. Se empleó la metodología de datos de panel con 911 firmas operativas en el sistema franquiciador mexicano. Los resultados reflejan un efecto de endogeneidad y crecimiento negativo del sector. La decisión de franquiciar tuvo en cuenta la situación económica y el tamaño entre otros aspectos que confirman los argumentos teóricos.

  6. Establishing a Link Between Prescription Drug Abuse and Illicit Online Pharmacies: Analysis of Twitter Data.

    Science.gov (United States)

    Katsuki, Takeo; Mackey, Tim Ken; Cuomo, Raphael

    2015-12-16

    that directly promoted NUPM by providing a URL that actively marketed the illegal online sale of prescription drugs of abuse. Additional research is needed to further establish the link between Twitter content and NUPM, as well as to help inform future technology-based tools, online health promotion activities, and public policy to combat NUPM online.

  7. Wireless data link for FBTR

    International Nuclear Information System (INIS)

    Sundararajan, M.K.; Prabhakara Rao, G.; Ilango Sambasivan, S.; Swaminathan, P.; Ramakrishna, P.V.

    2004-01-01

    This paper deals with the design and development of a wireless data link for transmission of block pile signals at the Fast Breeder Test Reactor (FBTR) of Indira Gandhi Center for Atomic Research (IGCAR). This link is to establish wireless connectivity, typically at RS232C rates, over distances of the order of 50 m, and is expected to operate under electrically hostile conditions. (author)

  8. Fluorocarbon assisted atomic layer etching of SiO{sub 2} and Si using cyclic Ar/C{sub 4}F{sub 8} and Ar/CHF{sub 3} plasma

    Energy Technology Data Exchange (ETDEWEB)

    Metzler, Dominik; Oehrlein, Gottlieb S., E-mail: oehrlein@umd.edu [Department of Materials Science and Engineering, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States); Li, Chen [Department of Physics, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States); Engelmann, Sebastian; Bruce, Robert L.; Joseph, Eric A. [IBM T. J. Watson Research Center, Yorktown Heights, New York 10598 (United States)

    2016-01-15

    The need for atomic layer etching (ALE) is steadily increasing as smaller critical dimensions and pitches are required in device patterning. A flux-control based cyclic Ar/C{sub 4}F{sub 8} ALE based on steady-state Ar plasma in conjunction with periodic, precise C{sub 4}F{sub 8} injection and synchronized plasma-based low energy Ar{sup +} ion bombardment has been established for SiO{sub 2} [Metzler et al., J. Vac. Sci. Technol. A 32, 020603 (2014)]. In this work, the cyclic process is further characterized and extended to ALE of silicon under similar process conditions. The use of CHF{sub 3} as a precursor is examined and compared to C{sub 4}F{sub 8}. CHF{sub 3} is shown to enable selective SiO{sub 2}/Si etching using a fluorocarbon (FC) film build up. Other critical process parameters investigated are the FC film thickness deposited per cycle, the ion energy, and the etch step length. Etching behavior and mechanisms are studied using in situ real time ellipsometry and x-ray photoelectron spectroscopy. Silicon ALE shows less self-limitation than silicon oxide due to higher physical sputtering rates for the maximum ion energies used in this work, ranged from 20 to 30 eV. The surface chemistry is found to contain fluorinated silicon oxide during the etching of silicon. Plasma parameters during ALE are studied using a Langmuir probe and establish the impact of precursor addition on plasma properties.

  9. Análisis preliminar del cuestionario señales de alerta de recaída (AWARE en drogodependientes peruanos

    Directory of Open Access Journals (Sweden)

    Cristian Solano

    2017-08-01

    Full Text Available RESUMEN: El objetivo del presente estudio fue analizar la estructura interna del cuestionario AWARE 3.0 en drogodependentientes. Fueron evaluados 240 sujetos en tratamiento residencial (hombres n=205 y mujeres n=35 entre 18 y 61 años con la escala de señales de alerta a recaída AWARE. Los análisis confirmaron la existencia de un solo factor, además se probaron cinco modelos confirmatorios incluyendo el factor de método que demostró influir en el modelo original. El análisis de confiabilidad obtuvo puntuaciones adecuadas tanto para variables observadas como variables latentes que representaron igualdad a nivel conceptual y de unidades (modelo congenérico y tau-equivalente. Los resultados indican un mejor ajuste solo con el modelo de ítems directos además de plantearse una versión breve. Estos hallazgos brindan una nueva perspectiva sobre la estructura del instrumento y una nueva versión que ayude a complementar la evaluación en el proceso de evaluación y detección de señales de alerta a recaídas. ABSTRACT: The objective of the present study was to analyze the internal structure of the AWARE 3.0 questionnaire in drug addicts. A total of 240 subjects undergoing residential treatment (males n = 205 and females n = 35 between 18 and 61 years with the AWARE relapse alert scale were evaluated. The analyzes confirmed the existence of a single factor, in addition five confirmatory models were tested including the factor of method that demonstrated to influence in the original model. The reliability analysis obtained adequate scores for both observed and latent variables that represented equality at the conceptual and unit level (congeneric and tau-equivalent models. The results indicate a better fit only with the direct item model in addition to a short version. These findings provide a new perspective on the structure of the instrument and a new version that helps complement the evaluation in the process of evaluation and detection of

  10. Estimating Rain Attenuation In Satellite Communication Links

    Science.gov (United States)

    Manning, R. M.

    1991-01-01

    Attenuation computed with help of statistical model and meteorological data. NASA Lewis Research Center Satellite Link Attenuation Model (SLAM) program QuickBASIC computer program evaluating static and dynamic statistical assessment of impact of rain attenuation on communication link established between Earth terminal and geosynchronous satellite. Application in specification, design, and assessment of satellite communication links for any terminal location in continental United States. Written in Microsoft QuickBASIC.

  11. Interfaz humano-computadora basada en señales de electrooculografía para personas con discapacidad motriz

    Directory of Open Access Journals (Sweden)

    Daniel Pacheco Bautista

    2014-05-01

    Full Text Available En este trabajo se presenta el desarrollo de un prototipo que asiste, a personas con cierta discapacidad motriz, en la interacción con la computadora de una forma simple y económica, mediante señales de electrooculografía. Esta técnica permite detectar los movimientos oculares basada en el registro de la diferencia de potencial existente entre la córnea y la retina, tal propiedad es aprovechada en este proyecto para controlar el desplazamiento del cursor del ratón de una forma precisa sobre la pantalla de la computadora. El prototipo es un diseño compacto alimentado de una fuente única de 5V proveniente del puerto USB y utiliza la circuitería ya implementada en cualquier ratón electromecánico convencional con mínimas modificaciones. El uso de tales dispositivos así como de electrodos convencionales hace el producto de un costo relativamente bajo en relación a las propuestas en otros trabajos.

  12. SEÑALES DE INVERSIÓN BASADAS EN UN ÍNDICE DE AVERSIÓN AL RIESGO

    Directory of Open Access Journals (Sweden)

    Gómez Martínez, Raúl

    2013-09-01

    Full Text Available Las estadísticas de búsquedas en internet constituyen una herramienta que cada vez tiene más peso en la investigación de las ciencias sociales. En este artículo proponemos utilizar las estadísticas de búsquedas en internet, obtenidas a través de la herramienta Google Insights, como indicador del estado de confianza o aversión al riesgo de los inversores. Con esta información elaboramos un índice de aversión al riesgo (IAR a partir del volumen de búsquedas realizadas en Google sobre ciertos términos económicos o financieros que se correlacionan negativamente con la evolución de los mercados. En este artículo demostramos empíricamente a través de un modelo econométrico que las estadísticas de búsquedas en Google aportan información relevante sobre la evolución de los mercados financieros y que el IAR aporta señales de inversión con capacidad predictiva sobre la evolución de los principales índices bursátiles europeos, observándose rentabilidades esperadas negativas si el IAR se incrementa y positivas en caso contrario.

  13. Power unit-cargo space link in transport

    Directory of Open Access Journals (Sweden)

    Radmilović Zoran R.

    2005-01-01

    Full Text Available This paper deals with transportation technology regarding links between power unit and cargo space. These links can be divided into two groups: rigid and flexible. Rigid link, established between power unit and cargo space, is dominant in maritime and road transport (sea ships and trucks, and occasionally in transport on inland waterways (self- propelled barges. Flexible link is used in the railroad transport (systems with trailers and semi trailers, and in inland waterway transport (push - towing and pulling systems, and combinations of the systems. The main goal of this research is determination of possible link types and organization of the means of transportation.

  14. Studiu teoretic al organelor de lucru de tip cuţit-disc ale maşinilor agricole

    Directory of Open Access Journals (Sweden)

    Iurie MELNIC

    2016-12-01

    Full Text Available Such conservation technologies as No-till, Mini-till, Strip-till etc., suppose the use of agricultural machines with rotary cutting units for such cultural practices as preparing the soil for planting, shredding and incorporation of crop residues into the soil and weed control. The paper presents a theoretical study of the operating process of the disc cultivator used for weed control (elaborated by the author with rotary cutting units (dynamic interaction of the rotary blade with the soil, the effect of friction force between the soil and the disc, the coordinates of soil particle relative to mobile coordinate system when rotation is done by an angle a and calculation elements of disc parameters. The main parameter of the developed device is disc diameter (it is chosen depending on the maximum working depth. As a result of the conducted study, we can affirm that the calculated disc diameter (for the working depth of h=0,16 m should be Dcalc=0,55 m. The studied block of rotary blades can be also used in the case of seedling planting machines, seed sowing machines and fertilizer spreading machines. Rezumat. Tehnologiile conservative No-Til, Mini-Till,Strip-Till etc. presupun folosirea maşinilor agricole cu organe de lucru de tip disc rotativ la efectuarea lucrărilor precum pregătirea solului pentru semănat, mărunţirea şi încorporarea în sol a resturilor vegetale şi combaterea buruienilor. În articol este prezentat un studiu teoretic al procesului de lucru al cultivatorului prăşitor (elaborat de autor cu organe de lucru de tip cuţit-disc circular (interacţiunea dinamică a cuţitului disc cu solul, acţiunea forţelor de frecare dintre sol şi disc, coordonatele particulei de sol în raport cu sistemul mobil de coordonate la rotirea sub un unghi a şi elemente de calcul ale parametrilor discului. În construcţia elaborată parametrul principal este diametrul discului (ales în funcţie de adâncimea maximă de lucru. În urma

  15. Establishing a Peer Client-Server Internet Architecture for Virginia's Schools.

    Science.gov (United States)

    Bull, Glen; And Others

    1996-01-01

    Virginia's Public Education Network (PEN) was one of the first statewide public school Internet systems. PEN began as a regional pilot that led to the establishment of a regional prototype, Teacher-LINK. Teacher-LINK in turn became the basis for the statewide K-12 Internet system. Topics include PEN's educational content, Internet services, and…

  16. X-linked hypophosphatemic rickets without 'rickets'

    International Nuclear Information System (INIS)

    Econs, M.J.; Feussner, J.R.; Quarles, L.D.; Veterans Administration Medical Center, Durham, NC; Samsa, G.P.; Veterans Administration Medical Center, Durham, NC; Effman, E.L.; Vogler, J.B.; Martinez, S.; Veterans Administration Medical Center, Durham, NC; Friedman, N.E.; Veterans Administration Medical Center, Durham, NC; Drezner, M.K.; Duke Univ. Medical Center, Durham, NC; Veterans Administration Medical Center, Durham, NC

    1991-01-01

    Wrist and knee radiographs from children with X-linked hypophosphatemic rickets were analyzed and compared with those from normal children and children with established rickets to assess whether radiographically apparent rickets is a consistent abnormality in X-linked hypophosphatemia. The absence or presence of rickets was correctly identified in 94.8% of wrist and knee films from normal and positive controls. In contrast, patients with X-linked hypophosphatemia exhibited rachitic abnormalities in only 5 of 11 wrist and 13 of 15 knee radiographs. Our data indicate that radiographically detectable rickets is a variable abnormality of X-linked hypophosphatemia and does not provide an unambiguous index for the diagnosis of this disease. (orig./GDG)

  17. The Strategic Organization of the Entrepreneurial Established Firm

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Lyngsie, Jacob

    2014-01-01

    The entrepreneurship field predominantly focuses on start-ups, opportunity discovery and single individual. These overall characteristics mean that the field has difficulties conceptualizing and theorizing the entrepreneurial activities of established firms. In particular, the links between organ...

  18. Espadas y puñales del bronce final: el depósito de armas de Puertollano (Ciudad Real

    Directory of Open Access Journals (Sweden)

    Montero Ruiz, Ignacio

    2002-12-01

    Full Text Available This paper deals with the technological study of a new Late Bronce Age hoard found in Puertollano (Ciudad Real. This hoard is a singular found in the context of Iberian Peninsula due to the number of items (14 swords and daggers and 1 fragment of ferrule and all of them are weapons. Elemental analysis by PIXE shows a Copper-Tin alloy with very low impurity pattern. A general comment about the real use of this weapons is included.

    Se presenta el estudio tecnológico de un nuevo depósito del Bronce Final aparecido en Puertollano (Ciudad Real. Compuesto exclusivamente por armas (14 espadas y puñales y un fragmento de regatón constituye un deposito singular entre los conocidos en la Península ibérica. Se incluyen los análisis de composición mediante técnica PIXE que indican que todas las piezas son bronces binarios Cu-Sn con bajo nivel de impurezas. Se discute sobre la funcionalidad y uso práctico de estas producciones armamentísticas.

  19. Site-directed cross-linking: establishing the dimeric structure of the aspartate receptor of bacterial chemotaxis

    International Nuclear Information System (INIS)

    Milligan, D.L.; Koshland, D.E. Jr.

    1988-01-01

    Cysteine residues introduced at specific locations in the aspartate receptor of Salmonella typhimurium provide anchor points for cross-linking and serve as chemical markers for structural studies of this oligomeric receptor. These markers have been used to measure the rate of subunit exchange between oligomeric receptors and to show that ligand binding inhibits this exchange. The cysteine-containing receptors can be oxidatively cross-linked to completion within the oligomeric receptor, indicating that the receptor has an even number of subunits. Based on this observation, a technique has been developed that can be used to determine the oligomeric structure of proteins under a variety of experimental conditions. The technique involves the measurement of the effect of dilution by cysteineless receptor subunits on cross-linking and reveals that the aspartate receptor is dimeric in detergent solution, in a mixed-micelle system, and in reconstituted membrane vesicles. Binding of aspartate does not change the oligomeric structure of the receptor, indicating that transmembrane signaling occurs within an oligomeric receptor of constant size

  20. Análisis estocástico de señales vibratorias de motores de inducción para la detección de fallas usando descomposición de modo empírico

    Directory of Open Access Journals (Sweden)

    Alejandro Rivera Roldán

    2015-04-01

    Full Text Available En este artículo se presenta un análisis de vibraciones en motores de inducción por medio de Modelos Ocultos de Markov (Hidden Markov Model - HMM aplicado a características obtenidas de la Descomposición de Modo Empírico (Empirical Mode Decomposition - EMD y transformada de Hilbert-Huang de señales de vibración obtenidas en las coordenadas x y y, con el fin de detectar fallas de funcionamiento en rodamientos y barras.  Además se presenta un análisis comparativo de la capacidad de las señales de vibración en dirección x y en dirección y, para aportar información en la detección de fallas. Así, un HMM ergódico inicializado y entrenado por medio del algoritmo de máxima esperanza, con convergencia en 10e-7 y un máximo de iteraciones de 100, se aplicó sobre el espacio de características y su desempeño fue determinado mediante validación cruzada 80-20 con 30 fold, obteniendo un alto desempeño para la detección de fallas en términos de exactitud.

  1. Collagen cross-linking in thin corneas

    Directory of Open Access Journals (Sweden)

    Prema Padmanabhan

    2013-01-01

    Full Text Available Collagen cross-linking (CXL has become the standard of care for progressive keratoconus, after numerous clinical studies have established its efficacy and safety in suitably selected eyes. The standard protocol is applicable in eyes which have a minimum corneal thickness of 400 μm after epithelial debridement. This prerequisite was stipulated to protect the corneal endothelium and intraocular tissues from the deleterious effect of ultraviolet-A (UVA radiation. However, patients with keratoconus often present with corneal thickness of less than 400 μm and could have otherwise benefited from this procedure. A few modifications of the standard procedure have been suggested to benefit these patients without a compromise in safety. Transepithelial cross-linking, pachymetry-guided epithelial debridement before cross-linking, and the use of hypoosmolar riboflavin are some of the techniques that have been attempted. Although clinical data is limited at the present time, these techniques are worth considering in patients with thin corneas. Further studies are needed to scientifically establish their efficacy and safety.

  2. The moduli space of instantons on an ALE space from 3d $\\mathcal{N}=4$ field theories

    CERN Document Server

    Mekareeya, Noppadol

    2015-01-01

    The moduli space of instantons on an ALE space is studied using the moduli space of $\\mathcal{N}=4$ field theories in three dimensions. For instantons in a simple gauge group $G$ on $\\mathbb{C}^2/\\mathbb{Z}_n$, the Hilbert series of such an instanton moduli space is computed from the Coulomb branch of the quiver given by the affine Dynkin diagram of $G$ with flavour nodes of unitary groups attached to various nodes of the Dynkin diagram. We provide a simple prescription to determine the ranks and the positions of these flavour nodes from the order of the orbifold $n$ and from the residual subgroup of $G$ that is left unbroken by the monodromy of the gauge field at infinity. For $G$ a simply laced group of type $A$, $D$ or $E$, the Higgs branch of such a quiver describes the moduli space of instantons in projective unitary group $PU(n) \\cong U(n)/U(1)$ on orbifold $\\mathbb{C}^2/\\hat{G}$, where $\\hat{G}$ is the discrete group that is in McKay correspondence to $G$. Moreover, we present the quiver whose Coulomb ...

  3. Establecimiento de una base de datos de señales de vibraciones acústicas e imágenes termográficas infrarrojas para un sistema mecánico rotativo con la combinación de diferentes tipos de fallos y elaboración de guías de prácticas para detección de fallos en engranajes

    OpenAIRE

    Guiracocha Guiracocha, Rómulo Andrés

    2015-01-01

    El proyecto genera bases de datos de señales de emisión acústica, señales de vibración mecánicas e imágenes termográficas sobre un sistema mecánico rotativo que servirán en el diagnóstico de fallos aplicado al monitoreo de la condición y se generan guías de práctica para el análisis de vibraciones mecánicas en caja de engranajes y evaluación térmica de rodamientos. This project generates databases of acoustic emission signals, mechanical vibration signals and thermal images on a rotating m...

  4. Mathematical modelling in volume per hectare of Pinus caribaea Morelet var. caribaea Barret y Golfari at the «Jazmines» silvicultural unit, Viñales

    Directory of Open Access Journals (Sweden)

    Juana Teresa Suárez Sarria

    2013-12-01

    Full Text Available Mathematical modelling constitutes a very useful tool for the planning and administration of the forest ecosystems. With the objective of predicting the behavior of volume by hectare of Pinus caribaea Moreletvar. caribaea. Barret y Golfari plantations at the «Jazmines» Silvicultural Unit, Viñales, seven non-lineal regression models were evaluated. The best goodness of fit model was the volume per hectare was the one designed by Hossfeld I, with a determining coefficient of 63, 9 % with a high significance parameter (P <0.001. The description curves for the annual mean increment with the time (IMA and the annual periodical increment (ICA of this variables were provided.

  5. On the Reproducibility of Label-Free Quantitative Cross-Linking/Mass Spectrometry

    Science.gov (United States)

    Müller, Fränze; Fischer, Lutz; Chen, Zhuo Angel; Auchynnikava, Tania; Rappsilber, Juri

    2018-02-01

    Quantitative cross-linking/mass spectrometry (QCLMS) is an emerging approach to study conformational changes of proteins and multi-subunit complexes. Distinguishing protein conformations requires reproducibly identifying and quantifying cross-linked peptides. Here we analyzed the variation between multiple cross-linking reactions using bis[sulfosuccinimidyl] suberate (BS3)-cross-linked human serum albumin (HSA) and evaluated how reproducible cross-linked peptides can be identified and quantified by LC-MS analysis. To make QCLMS accessible to a broader research community, we developed a workflow that integrates the established software tools MaxQuant for spectra preprocessing, Xi for cross-linked peptide identification, and finally Skyline for quantification (MS1 filtering). Out of the 221 unique residue pairs identified in our sample, 124 were subsequently quantified across 10 analyses with coefficient of variation (CV) values of 14% (injection replica) and 32% (reaction replica). Thus our results demonstrate that the reproducibility of QCLMS is in line with the reproducibility of general quantitative proteomics and we establish a robust workflow for MS1-based quantitation of cross-linked peptides.

  6. Reducción de interferencia de línea de potencia en señales electrocardiográficas mediante el filtro dual de Kalman

    Directory of Open Access Journals (Sweden)

    Luis David Avendaño Valencia

    2007-09-01

    Full Text Available En este artículo se presenta el desarrollo de un filtro para la reducción de la interferencia de línea de potencia en señales electrocardiográficas (ECG, basado en estimación dual de parámetros y de estado, empleando la filtración Kalman, en el cual se consideran modelos independientes entre la interferencia de línea de potencia y la señal ECG. Ambos modelos son combinados para simular la señal ECG medida sobre la que se realiza la estimación de estado para separar la señal de la interferencia. El algoritmo propuesto es sintonizado y comparado en un conjunto de pruebas realizadas sobre la base de datos QT de electrocardiografía. Inicialmente se hacen pruebas de sintonización del algoritmo para el rastreo de la señal ECG limpia, cuyos resultados son utilizados después para las pruebas de filtrado. Luego se llevan a cabo pruebas exhaustivas sobre la base de datos QT en la filtración de interferencia de línea de potencia, la cual ha sido introducida artificialmente en los registros, para una relación de señal a ruido (SNR dada, obteniendo así curvas del desempeño del algoritmo, que permiten a su vez comparar con el desempeño de otros algoritmos de filtración, a saber, un filtro notch recursivo de respuesta infinita al impulso (IIR y un filtro de Kalman, basado en un modelo más simple para la señal ECG. Como resultado, se demuestra que el algoritmo de filtrado obtenido es robusto a los cambios de amplitud de la interferencia; además, conserva sus propiedades para los diferentes tipos de morfologías de señales ECG normales y patológicas.

  7. Anoplastie périnéale simple pour le traitement des malformations anorectales basses chez l'adulte, à propos de deux cas

    Science.gov (United States)

    Echchaoui, Abdelmoughit; Benyachou, Malika; Hafidi, Jawad; Fathi, Nahed; Mohammadine, Elhamid; ELmazouz, Samir; Gharib, Nour-eddine; Abbassi, Abdellah

    2014-01-01

    Les malformations anorectales chez l'adulte sont des anomalies congénitales rares du tube digestif qui prédominent chez le sexe féminin. Notre étude porte sur deux observations de malformation anorectale basses vues et traitées au stade adulte par les 2 équipes (plasticiens et viscéralistes) à l'Hôpital Avicenne à Rabat. Il s'agit d'un homme de 24 ans avec une dyschésie anale l'autre cas est une femme de 18 ans avec une malformation anovulvaire Les caractéristiques cliniques combinées avec les imageries radiologiques (lavement baryté, et la manométrie anorectale) ont confirmé qu'il s'agit d'une malfomation anorectale basse. Les deux cas sont corrigés par une reconstruction sphinctérienne, réimplantation anale avec anoplastie périnéale. Les suites opératoires étaient simples, pas de souffrance cutanée ou nécrose, avec changement de pansement gras chaque jour. Le résultat fonctionnel (la continence) était favorable pour les 2 patients. La présentation des MAR à l’âge adulte est rare, d’étiologie mal connu, elles apparaissent selon le mode sporadique. Les caractéristiques cliniques, couplées à l'imagerie (lavement baryté, IRM pelvienne), l'endoscopie et la manométrie anorectale, permettent de confirmer le diagnostic et classer ces anomalies en 3 types: basses, intermédiaires, et hautes. Les formes basses sont traités d'emblée par une réimplantation anale et anoplastie périnéale simple tels nos deux cas, elles peuvent être traités dans certains cas par un abaissement anorectale associé à une plastie V-Y permettant ainsi un emplacement anatomique correct de l'anus; alors que les formes hautes ou intermédiaires relèvent d'une chirurgie complexe avec souvent une dérivation digestive transitoire. Contrairement aux autres formes, Les formes basses ont un pronostic fonctionnel favorable. PMID:25667689

  8. FACTORI ŞI PARTICULARITĂŢI PSIHOSOCIALE ALE ADAPTĂRII COPIILOR CU CERINŢE EDUCAŢIONALE SPECIALE

    Directory of Open Access Journals (Sweden)

    Segiu TOMA

    2016-12-01

    Full Text Available În articol este abordată problema privind factorii şi particularităţile psihosociale ale adaptării copiilor cu CES în instituţii de învăţământ. Accentul se pune pe analiza factorilor psihologici, sociali, fiind evidenţiată „inteligenţa” ca un mecanism reglator. Alt factor ţine de motivaţia extrinsecă şi cea intrinsecă. Pe larg se analizează nivelul de aspiraţie, afectivitatea, capacitatea de autoreglare, imaginea de sine ca factori determinanţi ai adaptării copiilor cu CES în institu­ţiile de învăţământ.PSYCHOSOCIAL FACTORS AND PECULIARITIES OF ADAPTATION OF CHILDREN WITH SPECIAL EDUCATIONAL REQUIREMENTSThe article does not give address psychosocial factors and peculiarities of adaptation of children with SEN in schools. The focus is on analyzing the psychological, social factors, highlighting the "intelligence" as a regulatory mechanism. Another factor related to the intrinsic and extrinsic motivation extensively analyzed the level of aspiration, affect the ability of self-regulation, self-image, as drivers of adaptation of SEN children in educational institutions.          

  9. [Clinical application of super-link system theory in spinal cord injury patients during rehabilitation stage].

    Science.gov (United States)

    Chen, Hsiao-Yu

    2008-04-01

    The purpose of this paper is to introduce Super-Link System Theory, which is a theory of spinal cord injury rehabilitation. This theory has been developed using the grounded theory research method. By explaining the procedure for establishing a super-link system the paper explains the complex structure of this theory. Super-Link System Theory emphasizes that rehabilitation nurses 'build up their interpersonal relationships' with clients, family caregivers, the interdisciplinary team, and the community, and attempt to 'establish links' among them. They know these links have to be made with appropriate 'timing', and must be able to access the appropriate people when necessary. Super-link systems include the following four links: link to client with spinal cord injury, link to family caregiver, link to interdisciplinary rehabilitation team, and link to community. It can enable rehabilitation nurses to provide a better quality of nursing care to clients and their family caregivers, as well as promote their professional position in the interdisciplinary rehabilitation team.

  10. A DEMODULATOR OF PWM SIGNALS GENERATED FOR A DIGITAL ACCELEROMETER IS DEVELOPED USING A MICROCONTROLLER UN DEMODULADOR DE SEÑALES PWM GENERADAS POR UN ACELERÓMETRO DIGITAL ES DESARROLLADO USANDO UN MICROCONTROLADOR

    Directory of Open Access Journals (Sweden)

    Eduardo Pérez Lobato

    2006-08-01

    Full Text Available This paper presents the use of a microcontroller to demodulate two Pulse Width Modulated (PWM signals which are being generated by a digital accelerometer, to obtain their pulse widths and transmit them serially to a parallel port of a general purpose computer.Esta publicación presenta el uso de un microcontrolador para demodular dos señales PWM que están siendo generadas por un acelerómetro digital, obtener sus anchos y enviarlas en forma serial al puerto paralelo de un computador de propósitos generales.

  11. X-linked hypophosphatemic rickets without 'rickets'

    Energy Technology Data Exchange (ETDEWEB)

    Econs, M.J.; Feussner, J.R.; Quarles, L.D. (Duke Univ. Medical Center, Durham, NC (USA). Dept. of Medicine Veterans Administration Medical Center, Durham, NC (USA). Health Services Research Field Program); Samsa, G.P. (Duke Univ. Medical Center, Durham, NC (USA). Dept. of Biometry Veterans Administration Medical Center, Durham, NC (USA). Health Services Research Field Program); Effman, E.L.; Vogler, J.B.; Martinez, S. (Duke Univ. Medical Center, Durham, NC (USA). Dept. of Radiology Veterans Administration Medical Center, Durham, NC (USA). Health Services Research Field Program); Friedman, N.E. (Duke Univ. Medical Center, Durham, NC (USA). Dept. of Pediatrics Veterans Administration Medical Center, Durham, NC (USA). Health Services Research Field Program); Drezner, M.K. (Duke Univ. Medical Center, Durham, NC (USA). Dept. of Medicine Duke Univ. Medical Center, Durham, NC (USA). Dept. of Cell Biology Veterans Administration Medical Center, Durham, NC (USA). Health Services Research F

    1991-02-01

    Wrist and knee radiographs from children with X-linked hypophosphatemic rickets were analyzed and compared with those from normal children and children with established rickets to assess whether radiographically apparent rickets is a consistent abnormality in X-linked hypophosphatemia. The absence or presence of rickets was correctly identified in 94.8% of wrist and knee films from normal and positive controls. In contrast, patients with X-linked hypophosphatemia exhibited rachitic abnormalities in only 5 of 11 wrist and 13 of 15 knee radiographs. Our data indicate that radiographically detectable rickets is a variable abnormality of X-linked hypophosphatemia and does not provide an unambiguous index for the diagnosis of this disease. (orig./GDG).

  12. MODELUL PROIECTĂRII TRASEELOR INDIVIDUALE DE ÎNVĂŢARE ALE STUDENŢILOR ÎN MEDII DIGITALE

    Directory of Open Access Journals (Sweden)

    Ghenadie CABAC

    2017-03-01

    Full Text Available Abordarea individuală a instruirii, deşi permite a adapta procesul de formare la particularităţile individuale ale stu­denţilor, rămâne o abordare centrată pe profesor, iar calea după care studenţii parcurg o disciplină universitară (traseul de învăţare este una şi aceeaşi. Pentru a implica plenar studenţii în activitatea de învăţare, didactica modernă propune individualizarea instruirii prin construirea de către student a propriului program de formare. În lucrare este descris modelul proiectării traseelor individuale de învăţare ca activitate comună a cadrului didactic şi a studentului.MODEL DESIGN OF INDIVIDUAL LEARNING PATHWAY STUDENTS IN DIGITAL MEDIAAlthough individual approach to training allows to adapt the teaching process to students’ individual character­ristics, it remains a teacher-centered approach, but the path students follow while acquiring an academic discipline (learning path is the same. To fully engage students in learning activities, modern didactics individualizes instruct­tion by building the student's own training programme. The paper describes the model of designing individual learning paths as a joint activity between the teacher and the student.

  13. A Strategic Framework for the Establishment of International Production Facilities

    DEFF Research Database (Denmark)

    Nielsen, A.P.; Riis, Jens Ove

    2000-01-01

    Departing from the empirical observation that there often is a weak link between the corporate internationalisation strategies and the actual establishment of international production facilities. This paper describes a framework to overcome this problem. The basic idea in the framework is the dis...

  14. transformada de Fourier en tiempos cortos utilizada en el análisis de señales de vibración para determinar planos en las ruedas de un tren

    Directory of Open Access Journals (Sweden)

    Elkin Flórez

    2009-01-01

    Full Text Available Uno de los problemas comunes que se presentan en las ruedas de los trenes, es la presencia de planos. Éstos generan un impacto suficiente como para afectar el funcionamiento normal del tren. La detección temprana de planos en las ruedas permite realizar las correcciones necesarias (tornear la superficie de la rueda a fin de evitar daños a los componentes del tren que degraden la prestación del servicio a los usuarios. Aunque existen muchos sensores de vibración en el mercado para detectar vibraciones generadas por el paso de un tren, no hay aún una herramienta estándar que permitan detectar la presencia de planos en las ruedas del mismo. Este estudio presenta la selección apropiada de una ventana temporal para utilizar la Transformada de Fourier en Tiempos Cortos (STFT, por sus siglas en inglés en el análisis de señales de vibración, tomadas al pie del carril y generadas al paso de un tren, que permita determinar la presencia de dichos planos. Para ello, en primer lugar se generó, utilizando la herramienta Matlab, una señal que simule la presencia de un plano y que permita conocer como la STFT, implementando diferentes ventanas temporales (Rectangular, Gauss, Hanning y Chebyshev, permite descubrir la presencia del mismo, en el dominio conjunto tiempo-frecuencia. Seguidamente, se aplica la STFT a señales tomadas en campo. Los resultados obtenidos demuestran que la STFT es una herramienta efectiva para detectar planos en la rueda de los trenes, si la función ventana y sus parámetros se seleccionan correctamente al realizar un análisis tiempo-frecuencia.

  15. DE MUNICIPIOS Y TERRITORIOS: CENTRALIDAD Y MARGINALIDAD EN LA ORGANIZACIÓN DEL TERRITORIO RURAL DEL MUNICIPIO FLAVIO DE LOS BAÑALES (UNCASTILLO, ZARAGOZA

    Directory of Open Access Journals (Sweden)

    Javier Andreu Pintado

    2011-10-01

    Full Text Available El presente trabajo da cuenta de los resultados de la VI Campaña de Prospecciones Arqueológicas llevada a cabo en el marco del Plan de Investigación de la Fundación Uncastillo en la ciudad romana de Los Bañales. A partir de la presentación de siete nuevos yacimientos de carácter rural y de la revisión intensiva del territorio circundante a los mismos se realiza un análisis de los patrones del poblamiento rural en tornoa la ciudad romana a partir de delimitar los que –entre la época de Augusto y la Tardoantigüedad– debieron ser los elementos dinamizadores del poblamiento y los que, por el contrario, explicarían la aparente marginalidad –respecto de la ciudad– de algunos enclaves como el del posible uicus romano de El Zaticón de Biota y otros de la margen izquierda del curso del río Arba.

  16. Transducción de señales generadas a partir del receptor antigénico de los linfocitos T Transduction of signal generated from the antigenic receptor of T lymphocytes

    Directory of Open Access Journals (Sweden)

    Carlos Julio Montoya Guarín

    1999-04-01

    Full Text Available A diferencia de lo observado para los linfocitos B, que reconocen antígenos libres en forma nativa, los linfocitos T han evolucionado para reconocer pequeños péptidos antigénicos presentados por moléculas de histocompatibilidad en la superficie de células presentadoras especializadas o de células diana. Para ello los linfocitos T maduros cuentan con un grupo de proteínas de membrana que en conjunto se denominan complejo TCR. Este grupo de cadenas polipeptídicas se expresan en la membrana de los linfocitos T y cumplen una función doble: reconocer los fragmentos antigénicos presentados por las moléculas de histocompatibilidad y transmitir las señales de ese reconocimiento al interior del linfocito. Las consecuencias de esta señalización pueden variar desde la activación funcional hasta la anergia o la apoptosis. Gracias a una intensa investigación en esta área, en los últimos años se han revelado muchas de las proteínas involucradas en la transducción de señales en los linfocitos T y sus mecanismos de acción. En esta revisión se examinan los modelos que explican la dinámica de la ligación del TCR, las principales vías de transducción de señales, los agentes farmacológicos que han permitido su estudio y dos modelos de enfermedades humanas que presentan entre sus mecanismos fisiopatológicos alteraciones en las vías de señalización a través del TCR. T lymphocytes, in contrast to B lymphocytes which bind free antigens in a native form, recognize little antigenic peptides displayed on histocompatibility molecules in the surface of specialized or target cells. For this, mature T lymphocytes have a group of membrane proteins that together are named TCR complex. This group of polypeptide chains expresses in the membrane and has a double function: to recognize the antigenic fragments bound to histocompatibility molecules and to transmit signals arisen from the recognition to the inner of the lymphocyte. The consequences

  17. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, Jean Philippe; Knebelmann, Bertrand; Giatras, Iannis

    2003-01-01

    Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disease...... in girls and women. A "European Community Alport Syndrome Concerted Action" (ECASCA) group was established to delineate the Alport syndrome phenotype in each gender and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X...... to increase after the age of 60 yr in women. Because of the absence of genotype-phenotype correlation and the large intrafamilial phenotypic heterogeneity, early prognosis of the disease in X-linked Alport syndrome carriers remains moot. Risk factors for developing renal failure have been identified...

  18. Shrub-Steppe Seasons A Natural History of the Mid-Columbia Basin

    Energy Technology Data Exchange (ETDEWEB)

    LE Rogers

    1995-08-01

    This book collects and updates a series of articles about the natural history of the Mid-Columbia region. The articles first appeared as a monthly column titled ''Natural History'' in the Tri-City Herald, beginning in May 1991. My approach has been to condense the best of what is known about the ecology of the region to a manageable length with little in the way of technical language and terms. Admittedly, there is a bias toward those topics and species on which I have either been personally involved or observed as part of the ecology research programs conducted on the Fitzner/Eberhardt Arid Lands Ecology (ALE) Reserve. The ALE Reserve is situated on the northeast-facing flank of the Rattlesnake Hills. Rattlesnake Mountain with a crest of over 3,600 feet is visible throughout much of the Mid-Columbia. Shrub-steppe grasslands once covered a large part of the western United States but most have been converted to other uses. The ALE site is the only remaining sizeable acreage (120 square miles) that is in near pristine condition and provides the only clear indication as to what the early trappers, traders, pioneers, and tribal members may have encountered in their day-to-day activities. In this respect, ALE provides a visible touchstone linking the past with the present for all of us.

  19. A contemporary issue in demography: the rising age at first birth, pros and cons

    NARCIS (Netherlands)

    Beets, G.C.N.

    2011-01-01

    Two decades after Aleš Hrdlička’s death the introduction of effective contraceptives broke the evolutionary link between sexuality and procreation. Since then we decide about having children or not, and if we want them we can also decide about their timing. As a consequence the number of children

  20. Quantum field theory and link invariants

    International Nuclear Information System (INIS)

    Cotta-Ramusino, P.; Guadagnini, E.; Mintchev, M.; Martellini, M.

    1990-01-01

    A skein relation for the expectation values of Wilson line operators in three-dimensional SU(N) Chern-Simons gauge theory is derived at first order in the coupling constant. We use a variational method based on the properties of the three-dimensional field theory. The relationship between the above expectation values and the known link invariants is established. (orig.)

  1. Los suelos del Parque Nacional Viñales, Pinar del Río, Cuba. Condiciones genéticas y ambientales.

    Directory of Open Access Journals (Sweden)

    Efrén Jaimez Salgado

    2006-01-01

    Full Text Available Se realiza la cartografía digital y actualización de la clasificación y diagnóstico de suelos del área del «Parque Nacional Viñales», a partir de la implementación de un Sistema de Información de Suelos (sobre plataforma SIG, para el manejo y consulta oportuna de las correspondientes bases de datos por parte de las autoridades del Parque. Los suelos predominantes por excelencia corresponden al grupo Leptosoles (90%. Están seguidos en segundo lugar por el grupo Acrisoles (4,5%, los que se encuentran en asociación genética con el grupo Alisoles, (4,4% tratándose en ambos casos de suelos con muy alto grado de evolución edáfica, cuyo origen y evolución se deriva de la combinación de materiales parentales ricos en cuarzo y silicatos de aluminio, así como la existencia de períodos climáticos antiguos muy húmedos en esta zona montañosa del occidente de Cuba. Se describen los principales procesos degradantes encontrados en los suelos del Parque y algunas de las medidas más importantes a tomar para atenuarlos.

  2. An auxiliary optimization method for complex public transit route network based on link prediction

    Science.gov (United States)

    Zhang, Lin; Lu, Jian; Yue, Xianfei; Zhou, Jialin; Li, Yunxuan; Wan, Qian

    2018-02-01

    Inspired by the missing (new) link prediction and the spurious existing link identification in link prediction theory, this paper establishes an auxiliary optimization method for public transit route network (PTRN) based on link prediction. First, link prediction applied to PTRN is described, and based on reviewing the previous studies, the summary indices set and its algorithms set are collected for the link prediction experiment. Second, through analyzing the topological properties of Jinan’s PTRN established by the Space R method, we found that this is a typical small-world network with a relatively large average clustering coefficient. This phenomenon indicates that the structural similarity-based link prediction will show a good performance in this network. Then, based on the link prediction experiment of the summary indices set, three indices with maximum accuracy are selected for auxiliary optimization of Jinan’s PTRN. Furthermore, these link prediction results show that the overall layout of Jinan’s PTRN is stable and orderly, except for a partial area that requires optimization and reconstruction. The above pattern conforms to the general pattern of the optimal development stage of PTRN in China. Finally, based on the missing (new) link prediction and the spurious existing link identification, we propose optimization schemes that can be used not only to optimize current PTRN but also to evaluate PTRN planning.

  3. BID links ferroptosis to mitochondrial cell death pathways

    NARCIS (Netherlands)

    Neitemeier, Sandra; Jelinek, Anja; Laino, Vincenzo; Hoffmann, Lena; Eisenbach, Ina; Eying, Roman; Ganjam, Goutham K; Dolga, Amalia M; Oppermann, Sina; Culmsee, Carsten

    2017-01-01

    Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by

  4. Linking main-belt comets to asteroid families

    Science.gov (United States)

    Novakovic, B.; Hsieh, H. H.; Cellino, A.

    2012-09-01

    Here we present our results obtained by applying different methods in order to establish a firm link between the main-belt comets (MBCs) and colisionally-formed asteroid families (AFs), i.e, to possibly find additional line of evidence supporting the hypothesis that MBCs may be preferentially found among the members of young AFs.

  5. Thermally and photostimulated charge transfer on impurities and intrinsic defects in YAlO3

    International Nuclear Information System (INIS)

    Akkerman, V.A.; Bulka, G.P.; Vanshtejn, D.I.

    1989-01-01

    Methods of ESR and thermostimulated luminescence (TSL) were used to study thermo- and photostimulated change of valent state of impurity ions of iron, chromium and oxygen centers in YAlO 3 (YA). On the basis of recovery of ESR O 2 - intensity after pulsed irradiation it was established, that autolocalized holes (ALH) were mobile above 150 K with 0.54 eV activation energy. It is proposed that decay of autolocalized excitons (ALE) in YA is conditioned by thermal mobility of the hole component of ALE. Relationship of TSL with ESL data and results of high-temperature annealing of crystals in vacuum and in the air is discussed

  6. Elastic dynamic research of high speed multi-link precision press considering structural stiffness of rotation joints

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Feng Feng; Sun, Yu; Peng, Bin Bin [School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing (China)

    2016-10-15

    An elastic dynamic model of high-speed multi-link precision press considering structural stiffness of rotation joints was established by the finite element method. In the finite element model, rotation joint was established by four bar elements with equivalent stiffness, and connected link was established by beam element. Then, the elastic dynamics equation of the system was established, and modal superposition method was used to solve the dynamic response. Compared with the traditional elastic dynamic model with perfect constraint of the rotation joints, the elastic dynamic response value of the improved model is larger. To validate the presented new method of elastic dynamics analysis with stiffness of rotation joints, a related test of slider Bottom dead center (BDC) position in different speed was designed. The test shows that the model with stiffness of rotation joints is more reasonable. So it provides a reasonable theory and method for dynamic characteristics research of such a multi-link machine.

  7. Single-step link of the superdeformed band in 143Eu

    International Nuclear Information System (INIS)

    Atac, A.; Bergstroem, M.H.; Nyberg, J.; Persson, J.; Herskind, B.; Joss, D.T.; Lipoglavsek, M.; Tucek, K.

    1996-01-01

    A discrete γ-ray ransition with an energy of 3360.6 keV deexciting the second lowest SD state in 143 Eu has been discovered. It carries 3.2 % of the full intensity of the band and feeds into a nearly spherical state which is above the I = 35/2 (+) , E x =4947 keV level. The exact placement of the single-step link is, however, not established due to the specially complicated level scheme in the region of interest. The energy of the single-step link agrees well with the previously determined two-step links. (orig.)

  8. Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Horvath, Susanne E; Wagner, Andrea; Steyrer, Ernst; Daum, Günther

    2011-12-01

    In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. In the present study we investigated a possible link between TAG and PE metabolism by analyzing the contribution of the four different PE biosynthetic pathways to TAG formation, namely de novo PE synthesis via Psd1p and Psd2p, the CDP-ethanolamine (CDP-Etn) pathway and lyso-PE acylation by Ale1p. In cells grown on the non-fermentable carbon source lactate supplemented with 5mM ethanolamine (Etn) the CDP-Etn pathway contributed most to the cellular TAG level, whereas mutations in the other pathways displayed only minor effects. In cki1∆dpl1∆eki1∆ mutants bearing defects in the CDP-Etn pathway both the cellular and the microsomal levels of PE were markedly decreased, whereas in other mutants of PE biosynthetic routes depletion of this aminoglycerophospholipid was less pronounced in microsomes. This observation is important because Lro1p similar to the enzymes of the CDP-Etn pathway is a component of the ER. We conclude from these results that in cki1∆dpl1∆eki1∆ insufficient supply of PE to the PDAT Lro1p was a major reason for the strongly reduced TAG level. Moreover, we found that Lro1p activity was markedly decreased in cki1∆dpl1∆eki1∆, although transcription of LRO1 was not affected. Our findings imply that (i) TAG and PE syntheses in the yeast are tightly linked; and (ii) TAG formation by the PDAT Lro1p strongly depends on PE synthesis through the CDP-Etn pathway. Moreover, it is very likely that local availability of PE in microsomes is crucial for TAG synthesis through the Lro1p reaction. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, J P; Knebelmann, B; Giatras, I

    2000-01-01

    Alport syndrome (AS) is a type IV collagen hereditary disease characterized by the association of progressive hematuric nephritis, hearing loss, and, frequently, ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease....... Considerable allelic heterogeneity has been observed. A "European Community Alport Syndrome Concerted Action" has been established to delineate accurately the AS phenotype and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X...

  10. Acanthamoeba Species Keratitis in a Soft Contact Lens Wearer Molecularly Linked to Well Water

    Directory of Open Access Journals (Sweden)

    Samira Mubareka

    2006-01-01

    Full Text Available Acanthamoeba species keratitis has been associated with soft contact lens wear. In the present report, an epidemiological link was established between the patient's isolate and well water from the home using molecular methods. To the authors' knowledge, this is the first case in Canada where such a link has been established. Primary care practitioners and specialists, including ophthalmologists and infectious diseases specialists, must maintain a high degree of clinical suspicion in soft contact lens wearers with keratitis unresponsive to conventional topical and systemic treatment.

  11. Formaldehyde cross-linking and structural proteomics: Bridging the gap.

    Science.gov (United States)

    Srinivasa, Savita; Ding, Xuan; Kast, Juergen

    2015-11-01

    Proteins are dynamic entities constantly moving and altering their structures based on their functions and interactions inside and outside the cell. Formaldehyde cross-linking combined with mass spectrometry can accurately capture interactions of these rapidly changing biomolecules while maintaining their physiological surroundings. Even with its numerous established uses in biology and compatibility with mass spectrometry, formaldehyde has not yet been applied in structural proteomics. However, formaldehyde cross-linking is moving toward analyzing tertiary structure, which conventional cross-linkers have already accomplished. The purpose of this review is to describe the potential of formaldehyde cross-linking in structural proteomics by highlighting its applications, characteristics and current status in the field. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. EVALUAREA PROPRIETĂŢILOR DE SUPRAFAŢĂ ALE BENTONITULUI LĂRGUŢA (REPUBLICA MOLDOVA INTERCALAT CU OLIGOMERI DE ALUMINIU

    Directory of Open Access Journals (Sweden)

    Vasile RUSU

    2015-12-01

    Full Text Available Tratarea în prealabil a bentonitului Lărguţa cu soluţie diluată de acid (pH 2, în continuare fiind intercalat cu specii oligomerice de aluminiu, duce la modificarea proprietăţilor de suprafaţă ale adsorbanţilor intercalaţi – a acidităţii lor, a caracteristicilor sorbţional-structurale şi a stabilităţii termice. Cinetica conversiei acidului oleic la esterificarea cu alcool etilic este influenţată de caracterul acid al catalizatorilor utilizaţi. Modelările efectuate relevă că adsorbanţii intercalaţi, obţinuţi pe baza bentonitului Lărguţa, au perspective reale de a fi utilizaţi pentru obţinerea biocombustibilului din uleiuri vegetale.SURFACE PROPERTIES OF PILLARED BENTONITE LARGUTA (R. MOLDOVA PILLARED WITH ALUMINUM OLIGOMERIC SPECIESLarguta bentonite prior treatment with dilute acid (pH 2 further being pillared with aluminum oligomeric species, result in modification of the surface properties of the adsorbents - acidity, sorption-structural characteristics and thermal stability. The kinetics of the conversion of oleic acid to esterification with ethylic alcohol is influenced by the nature of the acid catalysts used. Pillared adsorbents obtained on the basis of bentonite Larguta (RM possess real prospects for obtaining bio-fuel from vegetable oils.

  13. A Study on the Link between Moral Judgment Competences and Critical Thinking Skills

    Science.gov (United States)

    Samanci, Nilay Keskin

    2015-01-01

    Although many studies have established a direct link between moral judgment competences and critical thinking skills, none has been found to reveal the nature of the link between these two skills in the national and international literature. The present study looked at biology and primary education teacher candidates' moral judgment and critical…

  14. Desarrollo de un sistema de adquisición y medición simultáneo de señales de máquinas rotativas empleando emisión acústica, vibraciones mecánicas y velocidad

    OpenAIRE

    Cardona Noreña, Bernardo Andrés

    2013-01-01

    La presente tesis está enfocada en el desarrollo de un sistema de adquisición de diferentes tipos de señales como vibración mecánica, emisión acústica y velocidad para su utilización en el laboratorio de máquinas rotativas de la Universidad Nacional de Colombia Sede Manizales. El sistema permite el monitoreo de condición de una maquina rotativa con la posibilidad de generar un conjunto de bases de datos para el desarrollo de metodologías de análisis orientadas al diagnóstico del estado de la ...

  15. Propagation measurements and multipath channel modelling for line-of-sight links at 19.5 GHz

    CSIR Research Space (South Africa)

    Naicker, K

    2006-06-01

    Full Text Available The research aims to characterise the performance of the link by evaluating the effects of multipath propagation under various meteorological conditions. A LOS link was established between the Howard College and Westville campuses of UKZN and passes...

  16. „Sice to vůbec neruší [...], ale pro mne je to velmi nešikovné.“ Nové souborné vydání Dvořákových děl podněcuje nový výzkum

    Czech Academy of Sciences Publication Activity Database

    Kachlík, Jan

    2011-01-01

    Roč. 19, č. 9 (2011), s. 15-17 ISSN 1210-8081 Institutional research plan: CEZ:AV0Z90580513 Keywords : Antonín Dvořák * The new Dvořák edition Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.muzikus.cz/klasicka-hudba-jazz-clanky/Sice-to-vubec-nerusi-ale-pro-mne-je-to-velmi-nesikovne-nove-souborne-vydani-Dvorakovych-del-podnecuje-novy-vyzkum~20~prosinec~2011/

  17. Crossref an update on article level linking and digital object identifiers

    CERN Multimedia

    2002-01-01

    Description of the CrossRef initiative, "an independent non-profit membership organization that was established by the publishing community to permit article linking based on digital object identifiers (DOIs)" (1 page).

  18. Revisiting the Link between Poverty and Child Labor: The Ghanaian Experience. Working Paper.

    Science.gov (United States)

    Blunch, Niels-Hugo; Verner, Dorte

    The link between poverty and child labor has been regarded as a well established fact, but recent research has questioned the validity of this link. Starting from the premise that child labor is not necessarily harmful, this paper analyzes the determinants of harmful child labor, viewed as labor that directly conflicts with children's human…

  19. Establishing managerial requirements for low-and intermediate-level waste repository

    International Nuclear Information System (INIS)

    Chung, C. W.; Lee, Y. K.; Kim, H. T.; Park, W. J.; Suk, T. W.; Park, S. H.

    2004-01-01

    This paper reviews basic considerations for establishing managerial requirements on the domestic low-and intermediate-level radioactive waste repository and presents the corresponding draft requirements. The draft emphasizes their close linking with the related regulations, standards and safety assessment for the repository. It also proposes a desirable direction towards harmonizing together with the existing waste acceptance requirements for the repository

  20. Forum Renascens (Los Bañales de Uncastillo, Zaragoza: Archaeology of Architecture of the Roman forum in the service of the dissemination through the Virtual Archaeology

    Directory of Open Access Journals (Sweden)

    Pablo Serrano Basterra

    2015-10-01

    Full Text Available An archaeological site concerning the remains of an ancient Roman city, developed mainly from 1st BC to III AD, in the area named "Los Bañales", is located at the south of the current town of Uncastillo (Zaragoza, Spain in Comarca de las Cinco Villas. From 2008 the archaeological site is been studied in a interdisciplinar research project leaded by Fundación Uncastillo under the autorizathion of Gobierno de Aragón. Last seasons of excavation have been focused in the forum, the ancient public square of the roman town, still in process of research. It was a quite small square but following all the requeriments of those type of buildings in Roman Achitecture. Using Blender software, a model of recreation of the forum is being done. The following paper presents a brief summary of the dossier of decissions concerning this recreation result, however, of the interdisciplinar cooperation between historians, archaeologists and architects.

  1. Arbitrary Lagrangian-Eulerian method for non-linear problems of geomechanics

    International Nuclear Information System (INIS)

    Nazem, M; Carter, J P; Airey, D W

    2010-01-01

    In many geotechnical problems it is vital to consider the geometrical non-linearity caused by large deformation in order to capture a more realistic model of the true behaviour. The solutions so obtained should then be more accurate and reliable, which should ultimately lead to cheaper and safer design. The Arbitrary Lagrangian-Eulerian (ALE) method originated from fluid mechanics, but has now been well established for solving large deformation problems in geomechanics. This paper provides an overview of the ALE method and its challenges in tackling problems involving non-linearities due to material behaviour, large deformation, changing boundary conditions and time-dependency, including material rate effects and inertia effects in dynamic loading applications. Important aspects of ALE implementation into a finite element framework will also be discussed. This method is then employed to solve some interesting and challenging geotechnical problems such as the dynamic bearing capacity of footings on soft soils, consolidation of a soil layer under a footing, and the modelling of dynamic penetration of objects into soil layers.

  2. Marketing activities and national development: is there a link ...

    African Journals Online (AJOL)

    The main objective of this study is to establish the link that exists between marketing and national development without losing sight of the intervening variables that might exist between them. The study suggested comparative advantage (CAD), resource-use efficiency (RUET), wealth creation (WECRE) as the possible ...

  3. Protocol for the establishment and operation of LTPP sections

    CSIR Research Space (South Africa)

    Jones, DJ

    2004-03-01

    Full Text Available and responsibilities • Site location and establishment • Data collection • Reporting criteria A set of data capture forms is provided. Keywords: Long term pavement performance, LTPP, APT, HVS Proposals for implementation: None... of pavement performance models used in pavement management systems. It is also recognized that the link between accelerated pavement testing (APT) and in- service pavement performance is through LTPP studies. While APT can, and does, provide significant...

  4. Establishing a common metric for depressive symptoms: linking the BDI-II, CES-D, and PHQ-9 to PROMIS depression.

    Science.gov (United States)

    Choi, Seung W; Schalet, Benjamin; Cook, Karon F; Cella, David

    2014-06-01

    Interest in measuring patient-reported outcomes has increased dramatically in recent decades. This has simultaneously produced numerous assessment options and confusion. In the case of depressive symptoms, there are many commonly used options for measuring the same or a very similar concept. Public and professional reporting of scores can be confused by multiple scale ranges, normative levels, and clinical thresholds. A common reporting metric would have great value and can be achieved when similar instruments are administered to a single sample and then linked to each other to produce cross-walk score tables (e.g., Dorans, 2007; Kolen & Brennan, 2004). Using multiple procedures based on item response theory and equipercentile methods, we produced cross-walk tables linking 3 popular "legacy" depression instruments-the Center for Epidemiologic Studies Depression Scale (Radloff, 1977; N = 747), the Beck Depression Inventory-II (Beck, Steer, & Brown, 1996; N = 748), and the 9-item Patient Health Questionnaire (Kroenke, Spitzer, & Williams, 2001; N = 1,120)-to the depression metric of the National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS; Cella et al., 2010). The PROMIS Depression metric is centered on the U.S. general population, matching the marginal distributions of gender, age, race, and education in the 2000 U.S. census (Liu et al., 2010). The linking relationships were evaluated by resampling small subsets and estimating confidence intervals for the differences between the observed and linked PROMIS scores; in addition, PROMIS cutoff scores for depression severity were estimated to correspond with those commonly used with the legacy measures. Our results allow clinicians and researchers to retrofit existing data of 3 popular depression measures to the PROMIS Depression metric and vice versa.

  5. POLITICI EDUCAȚIONALE – DIMENSIUNE A CONEXIUNII ȘI CONTINUITĂȚII ÎNTRE CICLURI ALE ÎNVĂȚĂMÂNTULUI SUPERIOR

    Directory of Open Access Journals (Sweden)

    Mihail PAIU

    2018-03-01

    Full Text Available În articol sunt abordate unele componente ale politicilor educaţionale ca dimensiune indispensabilă în asigurarea conexiunii şi continuităţii între ciclurile învăţământului superior în contextul necesităţii de a adapta formarea profesio­nală la cerinţele pieţei muncii. Este specificat rolul şi importanţa acordării serviciilor de sprijin în proiectarea carierei, accentul fiind pus pe prioritatea acestora în formarea şi dezvoltarea unei culturi antreprenoriale în cadrul învăţământului universitar.EDUCATIONAL POLICIES – DIMENSION OF CONNECTION AND CONTINUITY BETWEEN HIGHER EDUCATION CYCLESThe article discusses some components of educational policies as an indispensable dimension in ensuring the connection and continuity between higher education cycles in the context of the need to adapt vocational training to the requirements of the labor market, the role and importance of providing career support services such as the necessity and priority for university education in the formation and development of an entrepreneurship culture.

  6. Neuromuscular Alterations After Ankle Sprains: An Animal Model to Establish Causal Links After Injury.

    Science.gov (United States)

    Lepley, Lindsey K; McKeon, Patrick O; Fitzpatrick, Shane G; Beckemeyer, Catherine L; Uhl, Timothy L; Butterfield, Timothy A

    2016-10-01

    The mechanisms that contribute to the development of chronic ankle instability are not understood. Investigators have developed a hypothetical model in which neuromuscular alterations that stem from damaged ankle ligaments are thought to affect periarticular and proximal muscle activity. However, the retrospective nature of these studies does not allow a causal link to be established. To assess temporal alterations in the activity of 2 periarticular muscles of the rat ankle and 2 proximal muscles of the rat hind limb after an ankle sprain. Controlled laboratory study. Laboratory. Five healthy adult male Long Evans rats (age = 16 weeks, mass = 400.0 ± 13.5 g). Indwelling fine-wire electromyography (EMG) electrodes were implanted surgically into the biceps femoris, medial gastrocnemius, vastus lateralis, and tibialis anterior muscles of the rats. We recorded baseline EMG measurements while the rats walked on a motor-driven treadmill and then induced a closed lateral ankle sprain by overextending the lateral ankle ligaments. After ankle sprain, the rats were placed on the treadmill every 24 hours for 7 days, and we recorded postsprain EMG data. Onset time of muscle activity, phase duration, sample entropy, and minimal detectable change (MDC) were assessed and compared with baseline using 2-tailed dependent t tests. Compared with baseline, delayed onset time of muscle activity was exhibited in the biceps femoris (baseline = -16.7 ± 54.0 milliseconds [ms]) on day 0 (5.2 ± 64.1 ms; t 4 = -4.655, P = .043) and tibialis anterior (baseline = 307.0 ± 64.2 ms) muscles on day 3 (362.5 ± 55.9 ms; t 4 = -5.427, P = .03) and day 6 (357.3 ± 39.6 ms; t 4 = -3.802, P = .02). Longer phase durations were observed for the vastus lateralis (baseline = 321.9 ± 92.6 ms) on day 3 (401.3 ± 101.2 ms; t 3 = -4.001, P = .03), day 4 (404.1 ± 93.0 ms; t 3 = -3.320, P = .048), and day 5 (364.6 ± 105.2 ms; t 3 = -3.963, P = .03) and for the tibialis anterior (baseline = 103.9 ± 16.4 ms

  7. Beer identity in Denmark

    DEFF Research Database (Denmark)

    Mejlholm, Ole; Martens, M.

    2006-01-01

    In this study a sensory profiling and a consumer test including 10 commercially Danish beers were conducted. The 10 beer samples covered four types of beer namely; lager, strong lager, ale and wheat beer, representing both new and more established beers on the Danish market. A trained panel consi...

  8. Topology control algorithm for wireless sensor networks based on Link forwarding

    Science.gov (United States)

    Pucuo, Cairen; Qi, Ai-qin

    2018-03-01

    The research of topology control could effectively save energy and increase the service life of network based on wireless sensor. In this paper, a arithmetic called LTHC (link transmit hybrid clustering) based on link transmit is proposed. It decreases expenditure of energy by changing the way of cluster-node’s communication. The idea is to establish a link between cluster and SINK node when the cluster is formed, and link-node must be non-cluster. Through the link, cluster sends information to SINK nodes. For the sake of achieving the uniform distribution of energy on the network, prolongate the network survival time, and improve the purpose of communication, the communication will cut down much more expenditure of energy for cluster which away from SINK node. In the two aspects of improving the traffic and network survival time, we find that the LTCH is far superior to the traditional LEACH by experiments.

  9. Generalización de la teoría de señales y sistemas para su aplicación a la descripción, resolución y parametrización de problemas electromagnéticos

    OpenAIRE

    Heredia Juesas, Juan

    2014-01-01

    La Teoría de Señales y Sistemas (SST) desempeña un papel fundamental en la formación académica y profesional de la ingeniería eléctrica, así como en otras áreas científicas, tales como procesado de señal, electromagnetismo (EM), acústica o mecánica cuántica, por ejemplo. Aunque muchos autores presentan esta teoría siguiendo un esquema que es válido para el análisis general de los sistemas lineales no invariantes, se evita tratar con conceptos más generales que limitan en gran medida las expli...

  10. PhenoLink - a web-tool for linking phenotype to ~omics data for bacteria: application to gene-trait matching for Lactobacillus plantarum strains

    Directory of Open Access Journals (Sweden)

    Bayjanov Jumamurat R

    2012-05-01

    Full Text Available Abstract Background Linking phenotypes to high-throughput molecular biology information generated by ~omics technologies allows revealing cellular mechanisms underlying an organism's phenotype. ~Omics datasets are often very large and noisy with many features (e.g., genes, metabolite abundances. Thus, associating phenotypes to ~omics data requires an approach that is robust to noise and can handle large and diverse data sets. Results We developed a web-tool PhenoLink (http://bamics2.cmbi.ru.nl/websoftware/phenolink/ that links phenotype to ~omics data sets using well-established as well new techniques. PhenoLink imputes missing values and preprocesses input data (i to decrease inherent noise in the data and (ii to counterbalance pitfalls of the Random Forest algorithm, on which feature (e.g., gene selection is based. Preprocessed data is used in feature (e.g., gene selection to identify relations to phenotypes. We applied PhenoLink to identify gene-phenotype relations based on the presence/absence of 2847 genes in 42 Lactobacillus plantarum strains and phenotypic measurements of these strains in several experimental conditions, including growth on sugars and nitrogen-dioxide production. Genes were ranked based on their importance (predictive value to correctly predict the phenotype of a given strain. In addition to known gene to phenotype relations we also found novel relations. Conclusions PhenoLink is an easily accessible web-tool to facilitate identifying relations from large and often noisy phenotype and ~omics datasets. Visualization of links to phenotypes offered in PhenoLink allows prioritizing links, finding relations between features, finding relations between phenotypes, and identifying outliers in phenotype data. PhenoLink can be used to uncover phenotype links to a multitude of ~omics data, e.g., gene presence/absence (determined by e.g.: CGH or next-generation sequencing, gene expression (determined by e.g.: microarrays or RNA

  11. Simulation of Controller Pilot Data Link Communications over VHF Digital Link Mode 3

    Science.gov (United States)

    Bretmersky, Steven C.; Murawski, Robert; Nguyen, Thanh C.; Raghavan, Rajesh S.

    2004-01-01

    The Federal Aviation Administration (FAA) has established an operational plan for the future Air Traffic Management (ATM) system, in which the Controller Pilot Data Link Communications (CPDLC) is envisioned to evolve into digital messaging that will take on an ever increasing role in controller to pilot communications, significantly changing the way the National Airspace System (NAS) is operating. According to FAA, CPDLC represents the first phase of the transition from the current analog voice system to an International Civil Aviation Organization (ICAO) compliant system in which digital communication becomes the alternate and perhaps primary method of routine communication. The CPDLC application is an Air Traffic Service (ATS) application in which pilots and controllers exchange messages via an addressed data link. CPDLC includes a set of clearance, information, and request message elements that correspond to existing phraseology employed by current Air Traffic Control (ATC) procedures. These message elements encompass altitude assignments, crossing constraints, lateral deviations, route changes and clearances, speed assignments, radio frequency assignments, and various requests for information. The pilot is provided with the capability to respond to messages, to request clearances and information, to report information, and to declare/rescind an emergency. A 'free text' capability is also provided to exchange information not conforming to defined formats. This paper presents simulated results of the aeronautical telecommunication application Controller Pilot Data Link Communications over VHF Digital Link Mode 3 (VDL Mode 3). The objective of this simulation study was to determine the impact of CPDLC traffic loads, in terms of timely message delivery and capacity of the VDL Mode 3 subnetwork. The traffic model is based on and is used for generating air/ground messages with different priorities. Communication is modeled for the en route domain of the Cleveland

  12. Disrupting the Dissertation: Linked Data, Enhanced Publication and Algorithmic Culture

    Science.gov (United States)

    Tracy, Frances; Carmichael, Patrick

    2017-01-01

    This article explores how the three aspects of Striphas' notion of algorithmic culture (information, crowds and algorithms) might influence and potentially disrupt established educational practices. We draw on our experience of introducing semantic web and linked data technologies into higher education settings, focussing on extended student…

  13. Experimental evaluation of open-loop UpLink Power Control using ACTS

    Science.gov (United States)

    Dissanayake, Asoka

    1995-01-01

    The present investigation deals with the implementation of open-loop up-link power control using a beacon signal in the down-link frequency band as the control parameter. A power control system was developed and tested using the ACTS satellite. ACTS carries beacon signals in both up- and down-link bands with which the relationship between the up- and down-link fading can be established. A power controlled carrier was transmitted to the ACTS satellite from a NASA operated ground station and the transponded signal was received at COMSAT Laboratories using a terminal that was routinely used to monitor the two ACTS beacon signals. The experiment ran for a period of approximately six months and the collected data were used to evaluate the performance of the power control system. A brief review of propagation factors involved in estimating the up-link fade using a beacon signal in the down-link band are presented. The power controller design and the experiment configuration are discussed. Results of the experiment are discussed.

  14. Low frequency signals and the strategy of customer retention Las señales de baja frecuencia y la estrategia de retención de clientes Sinais de baixa frequência e a estratégia de retenção de clientes

    Directory of Open Access Journals (Sweden)

    Jessé Alves Amâncio

    2010-03-01

    Full Text Available Research results are reported about monitoring various internal company variables, such as Customer Service and Quality Control as related to the strategy for retaining customers. The purpose was to evaluate the ability to identify situations where customers leave during turbulent business environments according to the concepts of low and high frequency signals proposed by Ansoff (1993. Theses signals show, more or less explicitly, situations that require company action to retain customers. Inherently companies are not prepared to detect the low frequency signals, the more important during uncertainties. The case study method investigated a Brazilian freight company with quantitative and qualitative methods. Low frequency signals were not suitably detected while high frequency signals were not sufficient to identify critical customer retention situations. The conclusion was that in turbulent times, greater effort must be applied to monitor low frequency signals in order to implement an effective customer retention strategy.Este trabajo presenta los resultados de una investigación sobre la relación entre el seguimiento de variables internas a la empresa, tales como los registros de los Servicios de Atención al Cliente y de Control de Calidad, y la estrategia de retención de clientes. El objetivo fue evaluar la capacidad de identificación de situaciones de pérdida de clientes en ambientes de negocio turbulentos por medio del concepto de señales de alta y baja frecuencia propuesto por Ansoff (1993. Esas señales indican, de forma más explícita o más implícita, situaciones que necesitan la actuación de la empresa para la retención de los clientes. Se defiende que las empresas no están preparadas para detectar las señales de baja frecuencia, que son las más importantes en ambientes de incertidumbre. La metodología utilizada fue el estudio de caso, realizado en una empresa de servicios de transporte

  15. Principalele instrumente ale politicii de subvenționare a sectorului economic

    Directory of Open Access Journals (Sweden)

    Adrian Mihai INCEU

    2010-06-01

    Full Text Available In this study we make an analysis of the major models for subsidies of the budgetary policy. We illustrate the effects of various models to the financial indicators of a company. The main objective of our analysis is to demonstrate the links between the macroeconomic policies and financial economy at the microeconomic levels.

  16. Efeitos do ruído de tráfego na saúde: para além das "moléstias"

    Directory of Open Access Journals (Sweden)

    Julio Díaz Jiménez

    2015-12-01

    Full Text Available Os transtornos auditivos têm sido tradicionalmente associados ao ruído laboral das pessoas expostas. Recentemente, o ruído produzido nas proximidades de aeroportos foi relacionado com diferentes patologias, sobretudo as cardiovasculares. Nos últimos anos, o ruído ambiental das grandes cidades, principalmente devido ao tráfego, foi relacionado com diversas patologias, tanto de natureza cardiovascular, como respiratória e inclusivamente com diabetes. Neste trabalho, para além se fazer uma breve descrição dos estudos que relacionam o ruído ambiental com a morbilidade e os diferentes mecanismos biológicos implicados, possíveis de explicar nessas associações; apresentam-se os resultados de um conjunto de investigações que, mediante a Análise de Séries Temporais, relacionam o ruído de tráfego na cidade de Madrid com a mortalidade diária por causas circulatórias, respiratórias e diabetes na faixa etária de maiores de 65 anos. Assim como a mortalidade anual atribuída ao ruído de tráfego em Madrid e a sua comparação com a atribuição às PM2,5.

  17. Hypothyroidism and obesity: An intriguing link

    Directory of Open Access Journals (Sweden)

    Debmalya Sanyal

    2016-01-01

    Full Text Available According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients.

  18. ANALISIS KESESUAIAN LAHAN TINGKAT SATUAN PEMUKIMAN MENGGUNAKAN AUTOMATED LAND EVALUATION SYSTEM (ALES: STUDI KASUS RANTAU PANDAN SP-1, PROVINSI JAMBI

    Directory of Open Access Journals (Sweden)

    Widiatmaka Widiatmaka

    2012-07-01

    Full Text Available Landuse planning according to biophysical and economical land suitability as well as basic allocation for transmigration should be done in order to improve the well-being of transmigrants. Suitability should be analyzed for the selection of commodities which are the most appropriate biophysically and profitable economically. The study was done in the settlements unit of Rantau Pandan SP-1, Jambi Province. The study was conducted to determine the suitability of each part of land for cultivation of food crops, vegetables and perennial crops and to see the biophysical suitability and economical feasibility. The goal is to recommend the most appropriate type of cultivation. This study integrate the Arc-View GIS and Automated Land Evaluation System (ALES in the analysis of land suitability. The results showed that four agricultural commodities were observed showing land suitability class domination of S3 (marginally suitable with the most dominant limiting factors were erosion and nutrient retention. The results of the analysis have been used for the determination of land use recommendations in the transmigration sites, presented spatially. Recommendations given based on the results of the analysis were not always in line with the land use recomended by government on dry land transmigration. Nonetheless, these results was suggested to be applied, either by considerations of conservation land and the consideration of economic benefit and farmers welfare. Key words: Land evaluation, transmigration, dry land farming, geographic information system

  19. [X-linked adrenoleukodystrophy: a report of three cases. The importance of early diagnosis].

    Science.gov (United States)

    López Úbeda, Marta; de Arriba Muñoz, Antonio; Ferrer Lozano, Marta; Labarta Aizpún, José I; García Jiménez, María C

    2017-10-01

    X-linked adrenoleukodystrophy is the most common peroxisomal disorder. This disease is caused by a defect in the ABCD1 gen. Saturated very long chain fatty acids are accumulated in serum, adrenal cortex and central nervous system white matter. The clinical spectrum is characterized by progressive neurological dysfunction and adrenal insufficiency with a devastating prognosis. We report a first case of X-linked adrenoleukodystrophy with fatal evolution which identified two asymptomatic family members and established a preventive treatment. Although there is no definitive cure, we stress the importance of family study and evaluation of the individual in situation of risk to establish an early preventive treatment and to give in each particular situation suitable professional advice. Sociedad Argentina de Pediatría.

  20. Overview of atomic layer etching in the semiconductor industry

    International Nuclear Information System (INIS)

    Kanarik, Keren J.; Lill, Thorsten; Hudson, Eric A.; Sriraman, Saravanapriyan; Tan, Samantha; Marks, Jeffrey; Vahedi, Vahid; Gottscho, Richard A.

    2015-01-01

    Atomic layer etching (ALE) is a technique for removing thin layers of material using sequential reaction steps that are self-limiting. ALE has been studied in the laboratory for more than 25 years. Today, it is being driven by the semiconductor industry as an alternative to continuous etching and is viewed as an essential counterpart to atomic layer deposition. As we enter the era of atomic-scale dimensions, there is need to unify the ALE field through increased effectiveness of collaboration between academia and industry, and to help enable the transition from lab to fab. With this in mind, this article provides defining criteria for ALE, along with clarification of some of the terminology and assumptions of this field. To increase understanding of the process, the mechanistic understanding is described for the silicon ALE case study, including the advantages of plasma-assisted processing. A historical overview spanning more than 25 years is provided for silicon, as well as ALE studies on oxides, III–V compounds, and other materials. Together, these processes encompass a variety of implementations, all following the same ALE principles. While the focus is on directional etching, isotropic ALE is also included. As part of this review, the authors also address the role of power pulsing as a predecessor to ALE and examine the outlook of ALE in the manufacturing of advanced semiconductor devices

  1. Overview of atomic layer etching in the semiconductor industry

    Energy Technology Data Exchange (ETDEWEB)

    Kanarik, Keren J., E-mail: keren.kanarik@lamresearch.com; Lill, Thorsten; Hudson, Eric A.; Sriraman, Saravanapriyan; Tan, Samantha; Marks, Jeffrey; Vahedi, Vahid; Gottscho, Richard A. [Lam Research Corporation, 4400 Cushing Parkway, Fremont, California 94538 (United States)

    2015-03-15

    Atomic layer etching (ALE) is a technique for removing thin layers of material using sequential reaction steps that are self-limiting. ALE has been studied in the laboratory for more than 25 years. Today, it is being driven by the semiconductor industry as an alternative to continuous etching and is viewed as an essential counterpart to atomic layer deposition. As we enter the era of atomic-scale dimensions, there is need to unify the ALE field through increased effectiveness of collaboration between academia and industry, and to help enable the transition from lab to fab. With this in mind, this article provides defining criteria for ALE, along with clarification of some of the terminology and assumptions of this field. To increase understanding of the process, the mechanistic understanding is described for the silicon ALE case study, including the advantages of plasma-assisted processing. A historical overview spanning more than 25 years is provided for silicon, as well as ALE studies on oxides, III–V compounds, and other materials. Together, these processes encompass a variety of implementations, all following the same ALE principles. While the focus is on directional etching, isotropic ALE is also included. As part of this review, the authors also address the role of power pulsing as a predecessor to ALE and examine the outlook of ALE in the manufacturing of advanced semiconductor devices.

  2. The costs of electoral fraud: establishing the link between electoral integrity, winning an election, and satisfaction with democracy.

    Science.gov (United States)

    Fortin-Rittberger, Jessica; Harfst, Philipp; Dingler, Sarah C

    2017-07-03

    Previous research has shown that voters' perception of electoral fairness has an impact on their attitudes and behaviors. However, less research has attempted to link objective measurements of electoral integrity on voters' attitudes about the democratic process. Drawing on data from the Comparative Study of Electoral Systems and the Quality of Elections Data, we investigate whether cross-national differences in electoral integrity have significant influences on citizens' level of satisfaction with democracy. We hypothesize that higher levels of observed electoral fraud will have a negative impact on evaluations of the democratic process, and that this effect will be mediated by a respondent's status as a winner or loser of an election. The article's main finding is that high levels of electoral fraud are indeed linked to less satisfaction with democracy. However, we show that winning only matters in elections that are conducted in an impartial way. The moment elections start to display the telltale signs of manipulation and malpractice, winning and losing no longer have different effects on voter's levels of satisfaction with democracy.

  3. Linking Motivation and Commitment through Learning Activities in the Volunteer Sector.

    Science.gov (United States)

    Serafino, Allan

    2001-01-01

    Volunteer motivation and commitment are linked through learning about the organization, the job, and oneself. Volunteer managers should (1) identity volunteer motivations and establish conditions to support them; (2) identify learning activities appropriate for motivations and learning styles; (3) ensure congruence between volunteer learning and…

  4. Teleoperation over low bandwidth communication links

    International Nuclear Information System (INIS)

    Fryer, R.J.; Mair, G.M.; Clark, N.; Heng, J.

    1996-01-01

    Teleoperation is well established for many areas of hazardous environment working. Where such environments are well structured and contained, such as within a working plant, communications bandwidths need not be a constraining factor. However where the worksite is remote, large, poorly structured or damaged communications rapidly become a critical factor in the efficient deployment and use of teleoperation equipment. The paper justifies and describes means which we are exploring to reduce the required communications bandwidth for teleoperation whist retaining full functionality. Techniques involved include incorporation of local intelligence at the worksite, with bandwidth devoted to high-level up-link control signals and down-link feedback, and the use of highly compressed video feeding 'virtual reality type' HMDs to provide maximum system transparency for the operator. The work is drawing on previous experience with an 'anthropomorphic robot heat' for telepresence work, and proprietary algorithms capable of compressing full colour video to standard telephone modem data rates. (Author)

  5. Comparison of DNA-based techniques for differentiation of production strains of ale and lager brewing yeast.

    Science.gov (United States)

    Kopecká, J; Němec, M; Matoulková, D

    2016-06-01

    Brewing yeasts are classified into two species-Saccharomyces pastorianus and Saccharomyces cerevisiae. Most of the brewing yeast strains are natural interspecies hybrids typically polyploids and their identification is thus often difficult giving heterogenous results according to the method used. We performed genetic characterization of a set of the brewing yeast strains coming from several yeast culture collections by combination of various DNA-based techniques. The aim of this study was to select a method for species-specific identification of yeast and discrimination of yeast strains according to their technological classification. A group of 40 yeast strains were characterized using PCR-RFLP analysis of ITS-5·8S, NTS, HIS4 and COX2 genes, multiplex PCR, RAPD-PCR of genomic DNA, mtDNA-RFLP and electrophoretic karyotyping. Reliable differentiation of yeast to the species level was achieved by PCR-RFLP of HIS4 gene. Numerical analysis of the obtained RAPD-fingerprints and karyotype revealed species-specific clustering corresponding with the technological classification of the strains. Taxonomic position and partial hybrid nature of strains were verified by multiplex PCR. Differentiation among species using the PCR-RFLP of ITS-5·8S and NTS region was shown to be unreliable. Karyotyping and RFLP of mitochondrial DNA evinced small inaccuracies in strain categorization. PCR-RFLP of HIS4 gene and RAPD-PCR of genomic DNA are reliable and suitable methods for fast identification of yeast strains. RAPD-PCR with primer 21 is a fast and reliable method applicable for differentiation of brewing yeasts with only 35% similarity of fingerprint profile between the two main technological groups (ale and lager) of brewing strains. It was proved that PCR-RFLP method of HIS4 gene enables precise discrimination among three technologically important Saccharomyces species. Differentiation of brewing yeast to the strain level can be achieved using the RAPD-PCR technique. © 2016 The

  6. Helping Farmers Access Farmland: New Jersey's New Land Link Website

    Science.gov (United States)

    Schilling, Brian J.; Marxen, Lucas J.; Everett, Jeffrey C.; Miller, Camille L.; Kimmel, David A.; Cook, Justine C.

    2015-01-01

    Access to land is a common obstacle for beginning farmers and established farmers seeking to expand their operations. Particularly in urban-influenced areas, leasing farmland is often more financially feasible than fee ownership. Locating available land or the right leasing situation, however, can be difficult. NJ Land Link (http://njlandlink.org)…

  7. Validation of a Newly Developed Instrument Establishing Links Between Motivation and Academic Hardiness

    Directory of Open Access Journals (Sweden)

    Spiridon Kamtsios

    2016-02-01

    Full Text Available The purpose of the study was to establish the reliability, the structural and the convergent validity of the “Dimensions of Academic Hardiness Questionnaire” for late elementary school children. A sample of children (N = 1264 aged 10-12 years completed the questionnaire and the “Athens Coping Scale”. Multiple fit indices provided support that the 9-factor model had a good fit to the data. Reliability coefficients ranged from .68 to .83. The study provided also preliminary evidence of convergent validity of the “Dimensions of Academic Hardiness” scores with one theoretically related measure, the “Athens Coping Scale”. The results enrich the notion of Academic Hardiness in late elementary school children as the role of awareness and the role of children’s previous experiences has been distinguished. The relation between the “Dimensions of Academic Hardiness” and achievement goal orientations in children learning is also noted. These findings are discussed in the context of the relevant literature.

  8. Validation of a Newly Developed Instrument Establishing Links Between Motivation and Academic Hardiness.

    Science.gov (United States)

    Kamtsios, Spiridon; Karagiannopoulou, Evangelia

    2016-02-01

    The purpose of the study was to establish the reliability, the structural and the convergent validity of the "Dimensions of Academic Hardiness Questionnaire" for late elementary school children. A sample of children (N = 1264) aged 10-12 years completed the questionnaire and the "Athens Coping Scale". Multiple fit indices provided support that the 9-factor model had a good fit to the data. Reliability coefficients ranged from .68 to .83. The study provided also preliminary evidence of convergent validity of the "Dimensions of Academic Hardiness" scores with one theoretically related measure, the "Athens Coping Scale". The results enrich the notion of Academic Hardiness in late elementary school children as the role of awareness and the role of children's previous experiences has been distinguished. The relation between the "Dimensions of Academic Hardiness" and achievement goal orientations in children learning is also noted. These findings are discussed in the context of the relevant literature.

  9. Sex linked recessive dystonia parkinsonism of Panay, Philippines (XDP).

    Science.gov (United States)

    Lee, L V; Munoz, E L; Tan, K T; Reyes, M T

    2001-12-01

    Sex linked dystonia parkinsonism (XDP), also referred to as "lubag" in American literature, was described in 1975 occurring endemically in Panay, Philippines. It is an adult onset, sex linked, predominantly male, severe, progressive movement disorder with high penetrance and a high frequency of generalisation. The movement disorder is characterised by dystonic movements, usually starting in the 3rd or 4th decade, spreading to generalisation within two to five years. The dystonia coexists or is replaced by parkinsonism usually beyond the 10th year of illness. No treatment has been found to be effective. Neuroimaging shows caudate and putamenal atrophy in patients reaching the parkinsonian stage. Neuropathology reveals pronounced atrophy of the caudate and putamen, mostly in the cases with long standing illness. The sex linked pattern of inheritance has been established. Genetic studies have located the affected gene (DYT3) to Xq13.1, with one group mapping the XDP gene to a < 350 kb locus in the DXS 7117-DXS 559 region.

  10. Computationally efficient dynamic modeling of robot manipulators with multiple flexible-links using acceleration-based discrete time transfer matrix method

    DEFF Research Database (Denmark)

    Zhang, Xuping; Sørensen, Rasmus; RahbekIversen, Mathias

    2018-01-01

    This paper presents a novel and computationally efficient modeling method for the dynamics of flexible-link robot manipulators. In this method, a robot manipulator is decomposed into components/elements. The component/element dynamics is established using Newton–Euler equations, and then is linea......This paper presents a novel and computationally efficient modeling method for the dynamics of flexible-link robot manipulators. In this method, a robot manipulator is decomposed into components/elements. The component/element dynamics is established using Newton–Euler equations......, and then is linearized based on the acceleration-based state vector. The transfer matrices for each type of components/elements are developed, and used to establish the system equations of a flexible robot manipulator by concatenating the state vector from the base to the end-effector. With this strategy, the size...... manipulators, and only involves calculating and transferring component/element dynamic equations that have small size. The numerical simulations and experimental testing of flexible-link manipulators are conducted to validate the proposed methodologies....

  11. Revegetation Plan for Areas of the Fitzner-Eberhardt Arid Lands Ecology Reserve Affected by Decommissioning of Buildings and Infrastructure and Debris Clean-up Actions

    Energy Technology Data Exchange (ETDEWEB)

    Downs, Janelle L.; Durham, Robin E.; Larson, Kyle B.

    2011-01-01

    The U.S. Department of Energy (DOE), Richland Operations Office is working to remove a number of facilities on the Fitzner Eberhardt Arid Lands Ecology Reserve (ALE), which is part of the Hanford Reach National Monument. Decommissioning and removal of buildings and debris on ALE will leave bare soils and excavated areas that need to be revegetated to prevent erosion and weed invasion. Four main areas within ALE are affected by these activities (DOE 2009;DOE/EA-1660F): 1) facilities along the ridgeline of Rattlesnake Mountain, 2) the former Nike missile base and ALE HQ laboratory buildings, 3) the aquatic research laboratory at Rattlesnake Springs area, and 4) a number of small sites across ALE where various types of debris remain from previous uses. This revegetation plan addresses the revegetation and restoration of those land areas disturbed by decommissioning and removal of buildings, facilities and associated infrastructure or debris removal. The primary objective of the revegetation efforts on ALE is to establish native vegetation at each of the sites that will enhance and accelerate the recovery of the native plant community that naturally persists at that location. Revegetation is intended to meet the direction specified by the Environmental Assessment (DOE 2009; DOE/EA-1660F) and by Stipulation C.7 of the Memorandum of Agreement (MOA) for the Rattlesnake Mountain Combined Community Communication Facility and InfrastructureCleanup on the Fitzner/Eberhardt Arid Lands Ecology Reserve, Hanford Site, Richland Washington(DOE 2009; Appendix B). Pacific Northwest National Laboratory (PNNL) under contract with CH2M Hill Plateau Remediation Company (CPRC) and in consultation with the tribes and DOE-RL developed a site-specific strategy for each of the revegetation units identified within this document. The strategy and implementation approach for each revegetation unit identifies an appropriate native species mix and outlines the necessary site preparation activities

  12. New genetic loci link adipose and insulin biology to body fat distribution

    NARCIS (Netherlands)

    D. Shungin (Dmitry); T.W. Winkler (Thomas W.); D.C. Croteau-Chonka (Damien); T. Ferreira (Teresa); A. Locke (Adam); R. Mägi (Reedik); R.J. Strawbridge (Rona); T.H. Pers (Tune); K. Fischer (Krista); A.E. Justice (Anne); T. Workalemahu (Tsegaselassie); J.M.W. Wu (Joseph M. W.); M.L. Buchkovich (Martin); N.L. Heard-Costa (Nancy); T.S. Roman (Tamara S.); A. Drong (Alexander); C. Song (Ci); S. Gustafsson (Stefan); F.R. Day (Felix); T. Esko (Tõnu); M. Fall (Magnus); Z. Kutalik (Zolta'n); J. Luan; J.C. Randall (Joshua); A. Scherag (Andre); S. Vedantam (Sailaja); A.R. Wood (Andrew); J. Chen (Jin); R.S.N. Fehrmann (Rudolf); J. Karjalainen (Juha); B. Kahali (Bratati); C.-T. Liu (Ching-Ti); E.M. Schmidt (Ellen); D. Absher (Devin); N. Amin (Najaf); M. Beekman (Marian); J.L. Bragg-Gresham (Jennifer L.); S. Buyske (Steven); A. Demirkan (Ayşe); G.B. Ehret (Georg); M.F. Feitosa (Mary Furlan); A. Goel (Anuj); A.U. Jackson (Anne); T. Johnson (Toby); M.E. Kleber (Marcus); K. Kristiansson (Kati); M. Mangino (Massimo); I.M. Leach (Irene Mateo); M.C. Medina-Gomez (Carolina); C. Palmer (Cameron); D. Pasko (Dorota); S. Pechlivanis (Sonali); M.J. Peters (Marjolein); I. Prokopenko (Inga); A. Stanca'kova' (Alena); Y.J. Sung (Yun Ju); T. Tanaka (Toshiko); A. Teumer (Alexander); J.V. van Vliet-Ostaptchouk (Jana); L. Yengo (Loic); W. Zhang (Weihua); E. Albrecht (Eva); J. Ärnlöv (Johan); G.M. Arscott (Gillian M.); S. Bandinelli (Stefania); A. Barrett (Angela); C. Bellis (Claire); A.J. Bennett (Amanda); C. Berne (Christian); M. Blüher (Matthias); S. Böhringer (Stefan); F. Bonnet (Fabrice); Y. Böttcher (Yvonne); M. Bruinenberg (M.); D.B. Carba (Delia B.); I.H. Caspersen (Ida H.); R. Clarke (Robert); E.W. Daw (E. Warwick); J. Deelen (Joris); E. Deelman (Ewa); G. Delgado; A.S.F. Doney (Alex); N. Eklund (Niina); M.R. Erdos (Michael); K. Estrada Gil (Karol); E. Eury (Elodie); N. Friedrich (Nele); M. Garcia (Melissa); V. Giedraitis (Vilmantas); B. Gigante (Bruna); A. Go (Attie); A. Golay (Alain); H. Grallert (Harald); T.B. Grammer (Tanja); J. Gräsler (Jürgen); J. Grewal (Jagvir); C.J. Groves (Christopher); T. Haller (Toomas); G. Hallmans (Göran); C.A. Hartman (Catharina); M. Hassinen (Maija); C. Hayward (Caroline); K. Heikkilä (Kauko); K.H. Herzig; Q. Helmer (Quinta); H.L. Hillege (Hans); O.L. Holmen (Oddgeir); S.C. Hunt (Steven); A. Isaacs (Aaron); T. Ittermann (Till); A.L. James (Alan); I. Johansson (Inger); T. Juliusdottir (Thorhildur); I.-P. Kalafati (Ioanna-Panagiota); L. Kinnunen (Leena); W. Koenig (Wolfgang); I.K. Kooner (Ishminder K.); W. Kratzer (Wolfgang); C. Lamina (Claudia); K. Leander (Karin); N.R. Lee (Nanette R.); P. Lichtner (Peter); L. Lind (Lars); J. Lindström (Jaana); S. Lobbens (Stéphane); M. Lorentzon (Mattias); F. MacH (François); P.K. Magnusson (Patrik); A. Mahajan (Anubha); W.L. McArdle (Wendy); C. Menni (Cristina); S. Merger (Sigrun); E. Mihailov (Evelin); L. Milani (Lili); R. Mills (Rebecca); A. Moayyeri (Alireza); K.L. Monda (Keri); S.P. Mooijaart (Simon); T.W. Mühleisen (Thomas); A. Mulas (Antonella); G. Müller (Gabriele); M. Müller-Nurasyid (Martina); R. Nagaraja (Ramaiah); M.A. Nalls (Michael); N. Narisu (Narisu); N. Glorioso (Nicola); I.M. Nolte (Ilja M.); M. Olden (Matthias); N.W. Rayner (Nigel William); F. Renström (Frida); J.S. Ried (Janina); N.R. Robertson (Neil R.); L.M. Rose (Lynda); S. Sanna (Serena); H. Scharnagl (Hubert); S. Scholtens (Salome); B. Sennblad (Bengt); T. Seufferlein (Thomas); C.M. Sitlani (Colleen); G.D. Smith; K. Stirrups (Kathy); H.M. Stringham (Heather); J. Sundstrom (Johan); M. Swertz (Morris); A.J. Swift (Amy); A.C. Syvanen; B. Tayo (Bamidele); B. Thorand (Barbara); G. Thorleifsson (Gudmar); A. Tomaschitz (Andreas); C. Troffa (Chiara); F.V.A. van Oort (Floor); N. Verweij (Niek); J.M. Vonk (Judith); L. Waite (Lindsay); R. Wennauer (Roman); T. Wilsgaard (Tom); M.K. Wojczynski (Mary ); A. Wong (Andrew); Q. Zhang (Qunyuan); J.H. Zhao (Jing Hua); E.P. Brennan (Eoin P.); M. Choi (Murim); P. Eriksson (Per); L. Folkersen (Lasse); A. Franco-Cereceda (Anders); A.G. Gharavi (Ali G.); A.K. Hedman (Asa); M.-F. Hivert (Marie-France); J. Huang (Jinyan); S. Kanoni (Stavroula); F. Karpe (Fredrik); S. Keildson (Sarah); K. Kiryluk (Krzysztof); L. Liang (Liming); R.P. Lifton (Richard); B. Ma (Baoshan); A.J. McKnight (Amy J.); R. McPherson (Ruth); A. Metspalu (Andres); J.L. Min (Josine L.); M.F. Moffatt (Miriam); G.W. Montgomery (Grant); J. Murabito (Joanne); G. Nicholson (Ggeorge); A.S. Dimas (Antigone); C. Olsson (Christian); J.R.B. Perry (John); E. Reinmaa (Eva); R.M. Salem (Rany); N. Sandholm (Niina); E.E. Schadt (Eric); R.A. Scott (Robert); L. Stolk (Lisette); E.E. Vallejo (Edgar E.); H.J. Westra (Harm-Jan); K.T. Zondervan (Krina); P. Amouyel (Philippe); D. Arveiler (Dominique); S.J.L. Bakker (Stephan); J.P. Beilby (John); R.N. Bergman (Richard); J. Blangero (John); M.J. Brown (Morris); M. Burnier (Michel); H. Campbell (Harry); A. Chakravarti (Aravinda); P.S. Chines (Peter); S. Claudi-Boehm (Simone); F.S. Collins (Francis); D.C. Crawford (Dana); J. Danesh (John); U. de Faire (Ulf); E.J.C. de Geus (Eco); M. Dörr (Marcus); R. Erbel (Raimund); K. Hagen (Knut); M. Farrall (Martin); E. Ferrannini (Ele); J. Ferrieres (Jean); N.G. Forouhi (Nita); T. Forrester (Terrence); O.H. Franco (Oscar); R.T. Gansevoort (Ron); C. Gieger (Christian); V. Gudnason (Vilmundur); C.A. Haiman (Christopher); T.B. Harris (Tamara); A.T. Hattersley (Andrew); M. Heliovaara (Markku); A.A. Hicks (Andrew); A. Hingorani (Aroon); W. Hoffmann (Wolfgang); A. Hofman (Albert); G. Homuth (Georg); S.E. Humphries (Steve); E. Hypponen (Elina); T. Illig (Thomas); M.-R. Jarvelin (Marjo-Riitta); B. Johansen (Berit); P. Jousilahti (Pekka); A. Jula (Antti); J. Kaprio (Jaakko); F. Kee (F.); S. Keinanen-Kiukaanniemi (Sirkka); J.S. Kooner (Jaspal S.); C. Kooperberg (Charles); P. Kovacs (Peter); A. Kraja (Aldi); M. Kumari (Meena); K. Kuulasmaa (Kari); J. Kuusisto (Johanna); T.A. Lakka (Timo); C. Langenberg (Claudia); L. Le Marchand (Loic); T. Lehtimäki (Terho); V. Lyssenko (Valeriya); S. Männistö (Satu); A. Marette (Andre'); T.C. Matise (Tara C.); C.A. McKenzie (Colin A.); B. McKnight (Barbara); A.W. Musk (Arthur); S. Möhlenkamp (Stefan); A.D. Morris (Andrew); M. Nelis (Mari); C. Ohlsson (Claes); A.J. Oldehinkel (Albertine); K.K. Ong (Ken K.); C. Palmer (Cameron); B.W.J.H. Penninx (Brenda); A. Peters (Annette); P.P. Pramstaller (Peter Paul); O. Raitakari (Olli); T. Rankinen (Tuomo); D.C. Rao (Dabeeru C.); T.K. Rice (Treva K.); P.M. Ridker (Paul); M.D. Ritchie (Marylyn D.); I. Rudan (Igor); V. Salomaa (Veikko); N.J. Samani (Nilesh); J. Saramies (Jouko); M.A. Sarzynski (Mark A.); P.E.H. Schwarz (Peter E. H.); A.R. Shuldiner (Alan); J.A. Staessen (Jan); V. Steinthorsdottir (Valgerdur); R.P. Stolk (Ronald); K. Strauch (Konstantin); A. Tönjes (Anke); A. Tremblay (Angelo); E. Tremoli (Elena); M.-C. Vohl (Marie-Claude); U. Völker (Uwe); P. Vollenweider (Peter); J.F. Wilson (James F); J.C.M. Witteman (Jacqueline); L.S. Adair (Linda); M. Bochud (Murielle); B.O. Boehm (Bernhard); S.R. Bornstein (Stefan R.); C. Bouchard (Claude); S. Cauchi (Ste'phane); M. Caulfield (Mark); J.C. Chambers (John C.); D.I. Chasman (Daniel); R.S. Cooper (Richard S.); G.V. Dedoussis (George); L. Ferrucci (Luigi); P. Froguel (Philippe); H.J. Grabe (Hans Jörgen); A. Hamsten (Anders); J. Hui (Jennie); K. Hveem (Kristian); K.-H. Jöckel (Karl-Heinz); M. Kivimaki (Mika); D. Kuh (Diana); M. Laakso (Markku); Y. Liu (YongMei); W. März (Winfried); P. Munroe (Patricia); I. Njølstad (Inger); B.A. Oostra (Ben); C.N.A. Palmer (Colin); N.L. Pedersen (Nancy L.); M. Perola (Markus); L. Perusse (Louis); U. Peters (Ulrike); C. Power (Christopher); T. Quertermous (Thomas); R. Rauramaa (Rainer); F. Rivadeneira Ramirez (Fernando); T. Saaristo (Timo); D. Saleheen; J. Sinisalo (Juha); P.E. Slagboom (Eline); H. Snieder (Harold); T.D. Spector (Timothy); U. Thorsteinsdottir (Unnur); M. Stumvoll (Michael); J. Tuomilehto (Jaakko); A.G. Uitterlinden (André); M. Uusitupa (Matti); P. van der Harst (Pim); G. Veronesi (Giovanni); M. Walker (Mark); N.J. Wareham (Nick); H. Watkins (Hugh); H.E. Wichmann (Heinz Erich); G.R. Abecasis (Gonçalo); T.L. Assimes (Themistocles); S.I. Berndt (Sonja); M. Boehnke (Michael); I.B. Borecki (Ingrid); P. Deloukas (Panagiotis); L. Franke (Lude); T.M. Frayling (Timothy); L. Groop (Leif); D. Hunter (David); R.C. Kaplan (Robert); J.R. O´Connell; L. Qi (Lu); D. Schlessinger (David); D.P. Strachan (David); J-A. Zwart (John-Anker); C.M. van Duijn (Cornelia); C.J. Willer (Cristen); P.M. Visscher (Peter); J. Yang (Joanna); J.N. Hirschhorn (Joel N.); M.C. Zillikens (Carola); M.I. McCarthy (Mark); E.K. Speliotes (Elizabeth); K.E. North (Kari); C.S. Fox (Caroline S.); I.E. Barroso (Inês); P.W. Franks (Paul); D. Anderson (Denise); E. Ingelsson (Erik); I.M. Heid (Iris); R.J.F. Loos (Ruth); L.A. Cupples (Adrienne); A.P. Morris (Andrew); C.M. Lindgren (Cecilia); K.L. Mohlke (Karen)

    2015-01-01

    textabstractBody fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct

  13. The link class project : Collaborative virtual teams between Peru and The Netherlands

    NARCIS (Netherlands)

    Olivos Rossini, L.M.; Rincon, Sandra; Rutkowski, Anne-Francoise

    2015-01-01

    The Link Class Project presented in this article provides an example of established collaborative group activities to negotiate and build a report together in virtual teams composed of students at Universidad ESAN, Lima (Peru) and Tilburg University, Tilburg (Netherlands). It further analyzes the

  14. New genetic loci link adipose and insulin biology to body fat distribution

    DEFF Research Database (Denmark)

    Shungin, Dmitry; Winkler, Thomas W; Croteau-Chonka, Damien C.

    2015-01-01

    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome...

  15. Muscle intermediate filaments and their links to membranes and membranous organelles

    International Nuclear Information System (INIS)

    Capetanaki, Yassemi; Bloch, Robert J.; Kouloumenta, Asimina; Mavroidis, Manolis; Psarras, Stelios

    2007-01-01

    Intermediate filaments (IFs) play a key role in the integration of structure and function of striated muscle, primarily by mediating mechanochemical links between the contractile apparatus and mitochondria, myonuclei, the sarcolemma and potentially the vesicle trafficking apparatus. Linkage of all these membranous structures to the contractile apparatus, mainly through the Z-disks, supports the integration and coordination of growth and energy demands of the working myocyte, not only with force transmission, but also with de novo gene expression, energy production and efficient protein and lipid trafficking and targeting. Desmin, the most abundant and intensively studied muscle intermediate filament protein, is linked to proper costamere organization, myoblast and stem cell fusion and differentiation, nuclear shape and positioning, as well as mitochondrial shape, structure, positioning and function. Similar links have been established for lysosomes and lysosome-related organelles, consistent with the presence of widespread links between IFs and membranous structures and the regulation of their fusion, morphology and stabilization necessary for cell survival

  16. Adquisición de señales electrocardiográficas y características que las deterioran: Resultados experimentales

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Gutiérrez Martínez

    2010-07-01

    Full Text Available ResumenSe presentan en este artículo las características principales de una señal electrocardiográfica y se enuncian características que tienden a deteriorarla, tales como los niveles de DC presentes en el cuerpo, el ruido de alta frecuencia producto de la interferencia electromagnética de radio y el ruido de modo común de 60Hz entre otros. Se presenta el diagrama de bloques del sistema de adquisición de señales electrocardiográficas con conexión vía bluetooth al PC y las interfaces de usuario con las que interactúa el usuario. Se presentan los resultados con los que se evaluó el desempeño del sistema y las conclusiones que se pudieron extraer de dichos resultados.Palabras ClaveSeñal Electrocardiografía, Ancho de banda, Ruido de Modo Común, Retroalimentación de la pierna derecha (RLD, microcontrolador. AbstractThis article presents the main features of an ECG signal and states some characteristics that tend to deteriorate it. Such us, DC levels in the body, the high frequency noise resulting of electromagnetic interference, and common-mode noise 60HZ, among others. It also presents the system block diagrams of ECG signal acquisition via Bluetooth connection to PC and user interfaces with which the user interacts. The outcome of the performance evaluation of the system is expressed as well as the conclusions.Key Words:Electrocardiography signal, bandwidth, common mode noise, right leg feedback, microcontroller.

  17. Too Many Links in the Horizon; What is Next? Linked Views and Linked History

    NARCIS (Netherlands)

    E. Liarou (Erietta); S. Idreos (Stratos)

    2011-01-01

    textabstractThe trend for more online linked data becomes stronger. Foreseeing a future where ``everything" will be online and linked, we ask the critical question; what is next? We envision that managing, querying and storing large amounts of links and data is far from yet another query

  18. The Re-Establishment of Desiccation Tolerance in Germinated Arabidopsis thaliana Seeds and Its Associated Transcriptome

    NARCIS (Netherlands)

    Maia de Oliveira, J.; Dekkers, S.J.W.; Provart, N.J.; Ligterink, W.; Hilhorst, H.W.M.

    2011-01-01

    The combination of robust physiological models with “omics” studies holds promise for the discovery of genes and pathways linked to how organisms deal with drying. Here we used a transcriptomics approach in combination with an in vivo physiological model of re-establishment of desiccation tolerance

  19. Linking EEG signals, brain functions and mental operations: Advantages of the Laplacian transformation.

    Science.gov (United States)

    Vidal, Franck; Burle, Boris; Spieser, Laure; Carbonnell, Laurence; Meckler, Cédric; Casini, Laurence; Hasbroucq, Thierry

    2015-09-01

    Electroencephalography (EEG) is a very popular technique for investigating brain functions and/or mental processes. To this aim, EEG activities must be interpreted in terms of brain and/or mental processes. EEG signals being a direct manifestation of neuronal activity it is often assumed that such interpretations are quite obvious or, at least, straightforward. However, they often rely on (explicit or even implicit) assumptions regarding the structures supposed to generate the EEG activities of interest. For these assumptions to be used appropriately, reliable links between EEG activities and the underlying brain structures must be established. Because of volume conduction effects and the mixture of activities they induce, these links are difficult to establish with scalp potential recordings. We present different examples showing how the Laplacian transformation, acting as an efficient source separation method, allowed to establish more reliable links between EEG activities and brain generators and, ultimately, with mental operations. The nature of those links depends on the depth of inferences that can vary from weak to strong. Along this continuum, we show that 1) while the effects of experimental manipulation can appear widely distributed with scalp potentials, Laplacian transformation allows to reveal several generators contributing (in different manners) to these modulations, 2) amplitude variations within the same set of generators can generate spurious differences in scalp potential topographies, often interpreted as reflecting different source configurations. In such a case, Laplacian transformation provides much more similar topographies, evidencing the same generator(s) set, and 3) using the LRP as an index of response activation most often produces ambiguous results, Laplacian-transformed response-locked ERPs obtained over motor areas allow resolving these ambiguities. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Can Link Analysis Be Applied to Identify Behavioral Patterns in Train Recorder Data?

    Science.gov (United States)

    Strathie, Ailsa; Walker, Guy H

    2016-03-01

    A proof-of-concept analysis was conducted to establish whether link analysis could be applied to data from on-train recorders to detect patterns of behavior that could act as leading indicators of potential safety issues. On-train data recorders capture data about driving behavior on thousands of routine journeys every day and offer a source of untapped data that could be used to offer insights into human behavior. Data from 17 journeys undertaken by six drivers on the same route over a 16-hr period were analyzed using link analysis, and four key metrics were examined: number of links, network density, diameter, and sociometric status. The results established that link analysis can be usefully applied to data captured from on-vehicle recorders. The four metrics revealed key differences in normal driver behavior. These differences have promising construct validity as leading indicators. Link analysis is one method that could be usefully applied to exploit data routinely gathered by on-vehicle data recorders. It facilitates a proactive approach to safety based on leading indicators, offers a clearer understanding of what constitutes normal driving behavior, and identifies trends at the interface of people and systems, which is currently a key area of strategic risk. These research findings have direct applications in the field of transport data monitoring. They offer a means of automatically detecting patterns in driver behavior that could act as leading indicators of problems during operation and that could be used in the proactive monitoring of driver competence, risk management, and even infrastructure design. © 2015, Human Factors and Ergonomics Society.

  1. New genetic loci link adipose and insulin biology to body fat distribution

    NARCIS (Netherlands)

    Shungin, Dmitry; Winkler, Thomas W.; Croteau-Chonka, Damien C.; Ferreira, Teresa; Locke, Adam E.; Mägi, Reedik; Strawbridge, Rona J.; Pers, Tune H.; Fischer, Krista; Justice, Anne E.; Workalemahu, Tsegaselassie; Wu, Joseph M. W.; Buchkovich, Martin L.; Heard-Costa, Nancy L.; Roman, Tamara S.; Drong, Alexander W.; Song, Ci; Gustafsson, Stefan; Day, Felix R.; Esko, Tonu; Fall, Tove; Kutalik, Zoltán; Luan, Jian'an; Randall, Joshua C.; Scherag, André; Vedantam, Sailaja; Wood, Andrew R.; Chen, Jin; Fehrmann, Rudolf; Karjalainen, Juha; Kahali, Bratati; Liu, Ching-Ti; Schmidt, Ellen M.; Absher, Devin; Amin, Najaf; Anderson, Denise; Beekman, Marian; Bragg-Gresham, Jennifer L.; Buyske, Steven; Demirkan, Ayse; Ehret, Georg B.; Feitosa, Mary F.; Goel, Anuj; Jackson, Anne U.; Johnson, Toby; Kleber, Marcus E.; Kristiansson, Kati; Mangino, Massimo; Mateo Leach, Irene; Medina-Gomez, Carolina; Palmer, Cameron D.; Pasko, Dorota; Pechlivanis, Sonali; Peters, Marjolein J.; Prokopenko, Inga; Stančáková, Alena; Ju Sung, Yun; Tanaka, Toshiko; Teumer, Alexander; van Vliet-Ostaptchouk, Jana V.; Yengo, Loïc; Zhang, Weihua; Albrecht, Eva; Ärnlöv, Johan; Arscott, Gillian M.; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J.; Berne, Christian; Blüher, Matthias; Böhringer, Stefan; Bonnet, Fabrice; Böttcher, Yvonne; Bruinenberg, Marcel; Carba, Delia B.; Caspersen, Ida H.; Clarke, Robert; Daw, E. Warwick; Deelen, Joris; Deelman, Ewa; Delgado, Graciela; Doney, Alex S. F.; Eklund, Niina; Erdos, Michael R.; Estrada, Karol; Eury, Elodie; Friedrich, Nele; Garcia, Melissa E.; Giedraitis, Vilmantas; Gigante, Bruna; Go, Alan S.; Golay, Alain; Grallert, Harald; Grammer, Tanja B.; Gräßler, Jürgen; Grewal, Jagvir; Groves, Christopher J.; Haller, Toomas; Hallmans, Goran; Hartman, Catharina A.; Hassinen, Maija; Hayward, Caroline; Heikkilä, Kauko; Herzig, Karl-Heinz; Helmer, Quinta; Hillege, Hans L.; Holmen, Oddgeir; Hunt, Steven C.; Isaacs, Aaron; Ittermann, Till; James, Alan L.; Johansson, Ingegerd; Juliusdottir, Thorhildur; Kalafati, Ioanna-Panagiota; Kinnunen, Leena; Koenig, Wolfgang; Kooner, Ishminder K.; Kratzer, Wolfgang; Lamina, Claudia; Leander, Karin; Lee, Nanette R.; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Mach, François; Magnusson, Patrik K. E.; Mahajan, Anubha; McArdle, Wendy L.; Menni, Cristina; Merger, Sigrun; Mihailov, Evelin; Milani, Lili; Mills, Rebecca; Moayyeri, Alireza; Monda, Keri L.; Mooijaart, Simon P.; Mühleisen, Thomas W.; Mulas, Antonella; Müller, Gabriele; Müller-Nurasyid, Martina; Nagaraja, Ramaiah; Nalls, Michael A.; Narisu, Narisu; Glorioso, Nicola; Nolte, Ilja M.; Olden, Matthias; Rayner, Nigel W.; Renstrom, Frida; Ried, Janina S.; Robertson, Neil R.; Rose, Lynda M.; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Sennblad, Bengt; Seufferlein, Thomas; Sitlani, Colleen M.; Vernon Smith, Albert; Stirrups, Kathleen; Stringham, Heather M.; Sundström, Johan; Swertz, Morris A.; Swift, Amy J.; Syvänen, Ann-Christine; Tayo, Bamidele O.; Thorand, Barbara; Thorleifsson, Gudmar; Tomaschitz, Andreas; Troffa, Chiara; van Oort, Floor V. A.; Verweij, Niek; Vonk, Judith M.; Waite, Lindsay L.; Wennauer, Roman; Wilsgaard, Tom; Wojczynski, Mary K.; Wong, Andrew; Zhang, Qunyuan; Hua Zhao, Jing; Brennan, Eoin P.; Choi, Murim; Eriksson, Per; Folkersen, Lasse; Franco-Cereceda, Anders; Gharavi, Ali G.; Hedman, Åsa K.; Hivert, Marie-France; Huang, Jinyan; Kanoni, Stavroula; Karpe, Fredrik; Keildson, Sarah; Kiryluk, Krzysztof; Liang, Liming; Lifton, Richard P.; Ma, Baoshan; McKnight, Amy J.; McPherson, Ruth; Metspalu, Andres; Min, Josine L.; Moffatt, Miriam F.; Montgomery, Grant W.; Murabito, Joanne M.; Nicholson, George; Nyholt, Dale R.; Olsson, Christian; Perry, John R. B.; Reinmaa, Eva; Salem, Rany M.; Sandholm, Niina; Schadt, Eric E.; Scott, Robert A.; Stolk, Lisette; Vallejo, Edgar E.; Westra, Harm-Jan; Zondervan, Krina T.; Amouyel, Philippe; Arveiler, Dominique; Bakker, Stephan J. L.; Beilby, John; Bergman, Richard N.; Blangero, John; Brown, Morris J.; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chines, Peter S.; Claudi-Boehm, Simone; Collins, Francis S.; Crawford, Dana C.; Danesh, John; de Faire, Ulf; de Geus, Eco J. C.; Dörr, Marcus; Erbel, Raimund; Eriksson, Johan G.; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Forouhi, Nita G.; Forrester, Terrence; Franco, Oscar H.; Gansevoort, Ron T.; Gieger, Christian; Gudnason, Vilmundur; Haiman, Christopher A.; Harris, Tamara B.; Hattersley, Andrew T.; Heliövaara, Markku; Hicks, Andrew A.; Hingorani, Aroon D.; Hoffmann, Wolfgang; Hofman, Albert; Homuth, Georg; Humphries, Steve E.; Hyppönen, Elina; Illig, Thomas; Jarvelin, Marjo-Riitta; Johansen, Berit; Jousilahti, Pekka; Jula, Antti M.; Kaprio, Jaakko; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M.; Kooner, Jaspal S.; Kooperberg, Charles; Kovacs, Peter; Kraja, Aldi T.; Kumari, Meena; Kuulasmaa, Kari; Kuusisto, Johanna; Lakka, Timo A.; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lyssenko, Valeriya; Männistö, Satu; Marette, André; Matise, Tara C.; McKenzie, Colin A.; McKnight, Barbara; Musk, Arthur W.; Möhlenkamp, Stefan; Morris, Andrew D.; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J.; Ong, Ken K.; Palmer, Lyle J.; Penninx, Brenda W.; Peters, Annette; Pramstaller, Peter P.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rice, Treva K.; Ridker, Paul M.; Ritchie, Marylyn D.; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Saramies, Jouko; Sarzynski, Mark A.; Schwarz, Peter E. H.; Shuldiner, Alan R.; Staessen, Jan A.; Steinthorsdottir, Valgerdur; Stolk, Ronald P.; Strauch, Konstantin; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Vohl, Marie-Claude; Völker, Uwe; Vollenweider, Peter; Wilson, James F.; Witteman, Jacqueline C.; Adair, Linda S.; Bochud, Murielle; Boehm, Bernhard O.; Bornstein, Stefan R.; Bouchard, Claude; Cauchi, Stéphane; Caulfield, Mark J.; Chambers, John C.; Chasman, Daniel I.; Cooper, Richard S.; Dedoussis, George; Ferrucci, Luigi; Froguel, Philippe; Grabe, Hans-Jörgen; Hamsten, Anders; Hui, Jennie; Hveem, Kristian; Jöckel, Karl-Heinz; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; März, Winfried; Munroe, Patricia B.; Njølstad, Inger; Oostra, Ben A.; Palmer, Colin N. A.; Pedersen, Nancy L.; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Rivadeneira, Fernando; Saaristo, Timo E.; Saleheen, Danish; Sinisalo, Juha; Slagboom, P. Eline; Snieder, Harold; Spector, Tim D.; Thorsteinsdottir, Unnur; Stumvoll, Michael; Tuomilehto, Jaakko; Uitterlinden, André G.; Uusitupa, Matti; van der Harst, Pim; Veronesi, Giovanni; Walker, Mark; Wareham, Nicholas J.; Watkins, Hugh; Wichmann, H.-Erich; Abecasis, Goncalo R.; Assimes, Themistocles L.; Berndt, Sonja I.; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Franke, Lude; Frayling, Timothy M.; Groop, Leif C.; Hunter, David J.; Kaplan, Robert C.; O'Connell, Jeffrey R.; Qi, Lu; Schlessinger, David; Strachan, David P.; Stefansson, Kari; van Duijn, Cornelia M.; Willer, Cristen J.; Visscher, Peter M.; Yang, Jian; Hirschhorn, Joel N.; Zillikens, M. Carola; McCarthy, Mark I.; Speliotes, Elizabeth K.; North, Kari E.; Fox, Caroline S.; Barroso, Inês; Franks, Paul W.; Ingelsson, Erik; Heid, Iris M.; Loos, Ruth J. F.; Cupples, L. Adrienne; Morris, Andrew P.; Lindgren, Cecilia M.; Mohlke, Karen L.; Dastani, Zari; Timpson, Nicholas; Yuan, Xin; Henneman, Peter; Kizer, Jorge R.; Lyytikainen, Leo-Pekka; Fuchsberger, Christian; Small, Kerrin; Coassin, Stefan; Lohman, Kurt; Pankow, James S.; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J.; Greenwood, Celia M. T.; Ladouceur, Martin; Grimsby, Jonna; Manning, Alisa K.; Kooner, Jaspal; Mooser, Vincent E.; Kapur, Karen A.; Chambers, John; Frants, Rune; Willemsvan-vanDijk, Ko; Willems, Sara M.; Winkler, Thomas; Psaty, Bruce M.; Tracy, Russell P.; Brody, Jennifer; Chen, Ida; Viikari, Jorma; Kähönen, Mika; Evans, David M.; St Pourcain, Beate; Sattar, Naveed; Wood, Andy; Carlson, Olga D.; Egan, Josephine M.; van Heemst, Diana; Kedenko, Lyudmyla; Nuotio, Marja-Liisa; Loo, Britt-Marie; Harris, Tamara; Garcia, Melissa; Kanaya, Alka; Haun, Margot; Klopp, Norman; Wichmann, H. 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    2015-01-01

    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide

  2. Links between nuclear medicine and radiopharmacy

    International Nuclear Information System (INIS)

    Pelegrin, M.; Francois-Joubert, A.; Chassel, M.L.; Desruet, M.D.; Bolot, C.; Lao, S.

    2010-01-01

    Radiopharmaceuticals are nowadays under the responsibility of the radio-pharmacist because of their medicinal product status. Radiopharmacy belongs to the hospital pharmacy department, nevertheless, interactions with nuclear medicine department are important: rooms are included or located near nuclear medicine departments in order to respect radiation protection rules, more over staff, a part of the material and some activities are shared between the two departments. Consequently, it seems essential to formalize links between the radiopharmacy and the nuclear medicine department, setting the goals to avoid conflicts and to ensure patients' security. Modalities chosen for this formalization will depend on the establishment's organization. (authors)

  3. Interrelations and moderators of longitudinal links between marital satisfaction and depressive symptoms among couples in established relationships.

    Science.gov (United States)

    Kouros, Chrystyna D; Papp, Lauren M; Cummings, E Mark

    2008-10-01

    Extending research based on newlywed couples, this study investigated longitudinal associations between marital satisfaction and depressive symptoms in a community sample of 296 couples in established relationships (M = 13.25 years, SD = 5.98) with children (M age = 11.05 years, SD = 2.31). Support was found for reciprocal relations between marital satisfaction and depressive symptoms in couples with established relationships. Further extending previous work, the study showed that relationship length and hostile marital conflict were significant moderators of these linkages. Husbands in longer term relationships were more vulnerable to depressive symptoms in the context of marital problems compared with husbands in shorter term relationships. At higher levels of marital conflict, the negative relationship between marital satisfaction and depressive symptoms was strengthened. Reflecting an unexpected finding, increased conflict buffered spouses from marital dissatisfaction in the context of depressive symptoms. Copyright 2008 APA, all rights reserved.

  4. A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression.

    Science.gov (United States)

    Diener, Carsten; Kuehner, Christine; Brusniak, Wencke; Ubl, Bettina; Wessa, Michèle; Flor, Herta

    2012-07-02

    Major depressive disorder (MDD) is characterized by altered emotional and cognitive functioning. We performed a voxel-based whole-brain meta-analysis of functional neuroimaging data on altered emotion and cognition in MDD. Forty peer-reviewed studies in English-language published between 1998 and 2010 were included, which used functional neuroimaging during cognitive-emotional challenge in adult individuals with MDD and healthy controls. All studies reported between-groups differences for whole-brain analyses in standardized neuroanatomical space and were subjected to Activation Likelihood Estimation (ALE) of brain cluster showing altered responsivity in MDD. ALE resulted in thresholded and false discovery rate corrected hypo- and hyperactive brain regions. Against the background of a complex neural activation pattern, studies converged in predominantly hypoactive cluster in the anterior insular and rostral anterior cingulate cortex linked to affectively biased information processing and poor cognitive control. Frontal areas showed not only similar under- but also over-activation during cognitive-emotional challenge. On the subcortical level, we identified activation alterations in the thalamus and striatum which were involved in biased valence processing of emotional stimuli in MDD. These results for active conditions extend findings from ALE meta-analyses of resting state and antidepressant treatment studies and emphasize the key role of the anterior insular and rostral anterior cingulate cortex for altered emotion and cognition in MDD. Copyright © 2012 Elsevier Inc. All rights reserved.

  5. Consequences of atomic layer etching on wafer scale uniformity in inductively coupled plasmas

    Science.gov (United States)

    Huard, Chad M.; Lanham, Steven J.; Kushner, Mark J.

    2018-04-01

    Atomic layer etching (ALE) typically divides the etching process into two self-limited reactions. One reaction passivates a single layer of material while the second preferentially removes the passivated layer. As such, under ideal conditions the wafer scale uniformity of ALE should be independent of the uniformity of the reactant fluxes onto the wafers, provided all surface reactions are saturated. The passivation and etch steps should individually asymptotically saturate after a characteristic fluence of reactants has been delivered to each site. In this paper, results from a computational investigation are discussed regarding the uniformity of ALE of Si in Cl2 containing inductively coupled plasmas when the reactant fluxes are both non-uniform and non-ideal. In the parameter space investigated for inductively coupled plasmas, the local etch rate for continuous processing was proportional to the ion flux. When operated with saturated conditions (that is, both ALE steps are allowed to self-terminate), the ALE process is less sensitive to non-uniformities in the incoming ion flux than continuous etching. Operating ALE in a sub-saturation regime resulted in less uniform etching. It was also found that ALE processing with saturated steps requires a larger total ion fluence than continuous etching to achieve the same etch depth. This condition may result in increased resist erosion and/or damage to stopping layers using ALE. While these results demonstrate that ALE provides increased etch depth uniformity, they do not show an improved critical dimension uniformity in all cases. These possible limitations to ALE processing, as well as increased processing time, will be part of the process optimization that includes the benefits of atomic resolution and improved uniformity.

  6. Invited Article: Channel performance for indoor and outdoor terahertz wireless links

    Science.gov (United States)

    Ma, Jianjun; Shrestha, Rabi; Moeller, Lothar; Mittleman, Daniel M.

    2018-05-01

    One of the most exciting future applications of terahertz technology is in the area of wireless communications. As 5G systems incorporating a standard for millimeter-wave wireless links approach commercial roll-out, it is becoming clear that even this new infrastructure will not be sufficient to keep pace with the rapidly increasing global demand for bandwidth. One favorable solution that is attracting increasing attention for subsequent generations of wireless technology is to use higher frequencies, above 100 GHz. The implementation of such links will require significant advances in hardware, algorithms, and architecture. Although numerous research groups are exploring aspects of this challenging problem, many basic questions remain unaddressed. Here, we present an experimental effort to characterize THz wireless links in both indoor and outdoor environments. We report measurements at 100, 200, 300, and 400 GHz, using a link with a data rate of 1 Gbit/s. We demonstrate both line-of-sight and non-line-of-sight (specular reflection) links off of interior building walls. This work represents a first step to establish the feasibility of using THz carrier waves for data transmission in diverse situations and environments.

  7. Chronic Inflammation Links Cancer and Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Zhiming eLi

    2016-06-01

    Full Text Available An increasing number of genetic studies suggest that the pathogenesis of Parkinson’s disease (PD and cancer share common genes, pathways, and mechanisms. Despite a disruption in a wide range of similar biological processes, the end result is very different: uncontrolled proliferation and early neurodegeneration. Thus, the links between the molecular mechanisms that cause PD and cancer remain to be elucidated. We propose that chronic inflammation in neurons and tumors contributes to a microenvironment that favors the accumulation of DNA mutations and facilitates disease formation. This article appraises the key role of microglia, establishes the genetic role of COX2 and CARD15 in PD and cancer, and discusses prevention and treatment with this new perspective in mind. We examine the evidence that chronic inflammation is an important link between cancer and PD.

  8. Predicting synergy in atomic layer etching

    Energy Technology Data Exchange (ETDEWEB)

    Kanarik, Keren J. [Lam Research Corp., Fremont, CA (United States); Tan, Samantha [Lam Research Corp., Fremont, CA (United States); Yang, Wenbing [Lam Research Corp., Fremont, CA (United States); Kim, Taeseung [Lam Research Corp., Fremont, CA (United States); Lill, Thorsten [Lam Research Corp., Fremont, CA (United States); Kabansky, Alexander [Lam Research Corp., Fremont, CA (United States); Hudson, Eric A. [Lam Research Corp., Fremont, CA (United States); Ohba, Tomihito [Lam Research Corp., Fremont, CA (United States); Nojiri, Kazuo [Lam Research Corp., Fremont, CA (United States); Yu, Jengyi [Lam Research Corp., Fremont, CA (United States); Wise, Rich [Lam Research Corp., Fremont, CA (United States); Berry, Ivan L. [Lam Research Corp., Fremont, CA (United States); Pan, Yang [Lam Research Corp., Fremont, CA (United States); Marks, Jeffrey [Lam Research Corp., Fremont, CA (United States); Gottscho, Richard A. [Lam Research Corp., Fremont, CA (United States)

    2017-03-27

    Atomic layer etching (ALE) is a multistep process used today in manufacturing for removing ultrathin layers of material. In this article, the authors report on ALE of Si, Ge, C, W, GaN, and SiO2 using a directional (anisotropic) plasma-enhanced approach. The authors analyze these systems by defining an “ALE synergy” parameter which quantifies the degree to which a process approaches the ideal ALE regime. This parameter is inspired by the ion-neutral synergy concept introduced in the 1979 paper by Coburn and Winters. ALE synergy is related to the energetics of underlying surface interactions and is understood in terms of energy criteria for the energy barriers involved in the reactions. Synergistic behavior is observed for all of the systems studied, with each exhibiting behavior unique to the reactant–material combination. By systematically studying atomic layer etching of a group of materials, the authors show that ALE synergy scales with the surface binding energy of the bulk material. This insight explains why some materials are more or less amenable to the directional ALE approach. Furthermore, they conclude that ALE is both simpler to understand than conventional plasma etch processing and is applicable to metals, semiconductors, and dielectrics.

  9. A Glider-Assisted Link Disruption Restoration Mechanism in Underwater Acoustic Sensor Networks.

    Science.gov (United States)

    Jin, Zhigang; Wang, Ning; Su, Yishan; Yang, Qiuling

    2018-02-07

    Underwater acoustic sensor networks (UASNs) have become a hot research topic. In UASNs, nodes can be affected by ocean currents and external forces, which could result in sudden link disruption. Therefore, designing a flexible and efficient link disruption restoration mechanism to ensure the network connectivity is a challenge. In the paper, we propose a glider-assisted restoration mechanism which includes link disruption recognition and related link restoring mechanism. In the link disruption recognition mechanism, the cluster heads collect the link disruption information and then schedule gliders acting as relay nodes to restore the disrupted link. Considering the glider's sawtooth motion, we design a relay location optimization algorithm with a consideration of both the glider's trajectory and acoustic channel attenuation model. The utility function is established by minimizing the channel attenuation and the optimal location of glider is solved by a multiplier method. The glider-assisted restoration mechanism can greatly improve the packet delivery rate and reduce the communication energy consumption and it is more general for the restoration of different link disruption scenarios. The simulation results show that glider-assisted restoration mechanism can improve the delivery rate of data packets by 15-33% compared with cooperative opportunistic routing (OVAR), the hop-by-hop vector-based forwarding (HH-VBF) and the vector based forward (VBF) methods, and reduce communication energy consumption by 20-58% for a typical network's setting.

  10. Linking Strategy-As-Practice Knowledge and Multi-Stakeholder Brand Meaning Co-Creation

    DEFF Research Database (Denmark)

    Vallaster, Christine; von Wallpach, Sylvia

    2014-01-01

    In this paper, we adopt a strategy-as-practice perspective and establish a link to the practices of brand meaning cocreation. We contribute empirical insights gained in the context of a small, non-commercial institution. The results show that brand meaning co-creation is a fluid, social phenomenon...

  11. Linked data management

    CERN Document Server

    Hose, Katja; Schenkel, Ralf

    2014-01-01

    Linked Data Management presents techniques for querying and managing Linked Data that is available on today’s Web. The book shows how the abundance of Linked Data can serve as fertile ground for research and commercial applications. The text focuses on aspects of managing large-scale collections of Linked Data. It offers a detailed introduction to Linked Data and related standards, including the main principles distinguishing Linked Data from standard database technology. Chapters also describe how to generate links between datasets and explain the overall architecture of data integration systems based on Linked Data. A large part of the text is devoted to query processing in different setups. After presenting methods to publish relational data as Linked Data and efficient centralized processing, the book explores lookup-based, distributed, and parallel solutions. It then addresses advanced topics, such as reasoning, and discusses work related to read-write Linked Data for system interoperation. Desp...

  12. Saudi dental hygienists' opinions regarding establishing a professional association.

    Science.gov (United States)

    Joufi, A I; Wilder, R S; Curran, A E; Brame, J L

    2018-02-28

    To assess the opinions of dental hygienists in Saudi Arabia regarding the establishment of a professional association including the role it should have to meet their professional needs. A cross-sectional electronic survey using Qualtrics was utilized. IRB exemption was obtained prior to distribution. Although there are 298 licensed Saudi dental hygienists in Saudi Arabia, email addresses were only available for 101 respondents: those obtained previously by direct contact for the purpose of initiation of a professional association and those referred by the direct contacts. Subjects were emailed a link to the survey. Seventy-seven subjects responded fully to the survey yielding a response rate of 70.3%. Most 91.5% (n = 65) of the respondents favoured the establishment of a Saudi dental hygiene professional association. Eighty-eight per cent (n = 59) responded that such an association would promote development of the profession in the country at least somewhat and 86.6% (n = 58) agreed that their professional needs could be met by its establishment. Interestingly, half of those who did not support the creation of the professional association believed it would promote development of the profession and meet professional needs. A representative sample of dental hygienists in Saudi Arabia support the establishment of a professional association and feel that it would advocate and promote the dental hygiene profession in the country and meet their professional needs. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. S-LINK, a data link interface specification for the LHC era

    International Nuclear Information System (INIS)

    Bij, H.C. van der; McLaren, R.A.; Boyle, O.

    1996-01-01

    In the Technical Proposals for ATLAS, CMS and ALICE there is a requirement for several thousand data links. Although there is an obvious need for standardization, this seems difficult to achieve as the links run at different speeds, over different distances and have various constraints of power consumption, size and radiation hardness. An additional complication is that today we cannot decide which will be the most cost effective technology for the implementation of the final links. Furthermore, we must allow designers of boards at each end of the link, for example readout electronics and input buffers, to work in parallel with the development of the links. The S-LINK is a new concept which should provide the benefits of standardization without the limitations. The S-LINK specification defines, at both ends of the link, a simple FIFO-like user interface which remains independent of the technology used to implement the physical link. The physical link provides transfer of event data and control words, error detection, optional flow control and test facilities. This paper describes the S-LINK specification and gives examples of the use of the S-LINK, the physical links being designed, and the test equipment that is being developed

  14. LinkED: A Novel Methodology for Publishing Linked Enterprise Data

    Directory of Open Access Journals (Sweden)

    Shreyas Suresh Rao

    2017-01-01

    Full Text Available Semantic Web technologies have redefined and strengthened the Enterprise-Web interoperability over the last decade. Linked Open Data (LOD refers to a set of best practices that empower enterprises to publish and interlink their data using existing ontologies on the World Wide Web. Current research in LOD focuses on expert search, the creation of unified information space and augmentation of core data from an enterprise context. However, existing approaches for publication of enterprise data as LOD are domain-specific, ad-hoc and suffer from lack of uniform representation across domains. The paper proposes a novel methodology called LinkED that contributes towards LOD literature in two ways: (a streamlines the publishing process through five stages of cleaning, triplification, interlinking, storage and visualization; (b addresses the latest challenges in LOD publication, namely: inadequate links, inconsistencies in the quality of the dataset and replicability of the LOD publication process. Further, the methodology is demonstrated via the publication of digital repository data as LOD in a university setting, which is evaluated based on two semantic standards: Five-Star model and data quality metrics. Overall, the paper provides a generic LOD publication process that is applicable across various domains such as healthcare, e-governance, banking, and tourism, to name a few.

  15. Feasibility study on the establishment of the IAEA international nuclear university

    International Nuclear Information System (INIS)

    Lee, E. J.; Kim, Y. T.; Nam, Y. M. and others

    2002-09-01

    The purpose of this project is to support 2002-2003 the IAEA project D.4.0.2, facilitating education, training and research in nuclear science and related fields, especially for a feasibility study on the establishment of the Agency sponsored International Nuclear University. Through this project, the abstract principle for a feasibility study on the establishment of the Agency sponsored International Nuclear university, which contains the new concepts and its objectives, principles to achieve the objectives, its curriculum outline and operation system, suggested project activities, was developed and submitted to the Agency. The Korean proposal were presented several times at the IAEA meetings and other international meetings related nuclear human resources development for understanding the necessity of a feasibility study on the establishment of the Agency sponsored international nuclear university with Member States. And the Korean proposal included such as the organization of a worldwide network using information and communication technology among Merber States' research institutes and training/education centers, curriculum outline and operation system of the INU will be produced. Also for further cooperation of the IAEA INU project implementation with the Agency, hosting IAEA INIS mirror site, establishment of the RCA region office, establishment of the INTEC at the Korean Atomic Energy Research Institute, and advanced curriculum of nuclear technology linked with NT, BT, ET, IT were made progress as a part of conceptualizing of the IAEA project

  16. [Links between non-professional agents and the official Veterinary Services in sub-Saharan Africa].

    Science.gov (United States)

    Diop, B A; Bessin, R

    2004-04-01

    Para-professional agents known as auxiliaries, or community animal health workers, provide low-cost basic veterinary services to communities of livestock producers. A 2003 survey of 16 Sub-Saharan African countries, carried out as part of the Pan-African Programme for the Control of Epizootics, showed that in the majority of cases, the official Veterinary Services have no (or very few) links with the auxiliaries, although they are well aware of their existence and in some cases the auxiliaries have been trained by officials of the Veterinary Services. However, there are isolated cases of countries establishing more formal links, for example, recognising the status of an auxiliary, recognising auxiliaries with no definition of a status, attaching auxiliaries to Veterinary Service staff, establishing agreements for the provision of auxiliary services through livestock producer associations, harmonising auxiliary training programmes, issuing professional auxiliary cards, and setting up a consultation framework on the issue of auxiliaries. Unlike private veterinarians, agents of the official services do not generally perceive auxiliaries as competitors, and sometimes collaboration develops at this level. The authors propose several measures to improve links between the official Veterinary Services and auxiliaries, as follows: the fields of competence of auxiliaries should be defined and their curriculum harmonised, the status of auxiliaries should be recognised, a monitoring and assessment mechanism should be established at senior level in the Veterinary Services, training for livestock producers should be improved.

  17. EFICIENȚA APLICĂRII STANDARDELOR INTERNAȚIONALE DE RAPORTARE FINANCIARĂ (IFRS ÎN REPUBLICA MOLDOVA, ÎN CONDIȚIILE ACTUALE ALE ECONOMIEI DE PIAȚĂ

    Directory of Open Access Journals (Sweden)

    Svetlana MIHAILA

    2018-03-01

    Full Text Available În acest articol autorii își propun să furnizeze informații privind aplicabilitatea Standardelor Internaționale de Raportare Financiară (International Financial Reporting Standards (IFRS în Republica Moldova, având în vedere condițiile actuale ale economiei de piață. Mesajul acestui articol este definit de prezentarea unor situații, prin care se observă avantajele potențiale privind implementarea IFRS, privită din punctul de vedere al necesității. Totodată, sunt relatate și unele lacune posibile, în urma aplicării standardelor internaționale, ce s-ar referi la complicitate, costuri și concoradanță a informației.THE EFFICIENCY OF INTERNATIONAL FINANCIAL REPORTING STANDARDS APPLICATION IN REPUBLIC OF MOLDOVA IN THE CURRENT MARKET ECONOMY CONDITIONSIn this article the authors aim to provide information regarding the International Financial Reporting Standards inRepublicofMoldova, taking into account the current market economy conditions. The message of this article is to present some situations, by which can be noted the potential advantages on implementing IFRS, looking in terms of necessity. Also, are reported the possible gaps, after applying international standards, that would mean complicity, costs, and consistency of information. 

  18. Does global warning increase establishment rates of invasive alien species? A centurial time series analysis

    Science.gov (United States)

    Dingcheng Huang; Robert A. Haack; Runzhi. Zhang

    2011-01-01

    The establishment rate of invasive alien insect species has been increasing worldwide during the past century. This trend has been widely attributed to increased rates of international trade and associated species introductions, but rarely linked to environmental change. To better understand and manage the bioinvasion process, it is crucial to understand the...

  19. Sex-linked dominant

    Science.gov (United States)

    Inheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant; Y-linked dominant ... can be either an autosomal chromosome or a sex chromosome. It also depends on whether the trait ...

  20. CONTRACTUL DE VÂNZARE–CUMPĂRARE LA LICITAŢIE, ANALIZA JURIDICĂ A LEGISLAŢIEI NAŢIONALE ŞI INTERNAŢONALE ŞI ACCEPŢIUNILE JURIDICE ALE ACESTUIA

    Directory of Open Access Journals (Sweden)

    Petru Vîrlan

    2016-11-01

    Full Text Available Astăzi vânzarea la licitaţie este foarte des întâlnită în tot mai multe domenii, mai ales în mediul afacerilor, care este unul dinamic, necesită o permanentă dezvoltare şi efectuarea de tranzacţii cât mai eficiente şi în condiţii cât mai avan­ta­joase. Acest tip de vânzare are o istorie de dezvoltare destul de lungă, pe parcursul căreia respectiva instituţie a evoluat tot mai mult, astăzi având numeroase modalităţi şi reguli în acest sens.CONTRACT AUCTION SALE, NATIONAL AND INTERNATONAL LEGAL ANALYSIS AND ITS LEGAL ACCEPTANCEToday we see that auctioning is very common in more and more fields, especially in the business environment is very dynamic and requires a permanent development and trazacţii making the most efficient and more profitable conditions. This stock has a fairly long history of development and along during which this institution has evolved today increasingly having numerous ways and rules in this regard.

  1. Single-step linking transition from superdeformed to spherical states in {sup 143}Eu

    Energy Technology Data Exchange (ETDEWEB)

    Atac, A.; Axelsson, A.; Persson, J. [Uppsala Univ. (Sweden)] [and others

    1996-12-31

    A discrete {gamma}-ray transition which connects the second lowest SD state with a normally deformed one in {sup 143}Eu has been discovered. It has an energy of 3360.6 keV and carries 3.2 % of the full intensity of the SD band. It feeds into a nearly spherical state which is above the I = 35/2{sup +}, E=4947 keV level. The exact placement of the single-step link could, however, not be established due to the especially complicated level scheme in the region of interest. The angular correlation study favours a stretched dipole character for the 3360.6 keV transition. The single-step link agrees well with the previously determined two-step links, both with respect to energy and spin.

  2. Linking mechanistic data to endpoints of regulatory concern using the adverse outcome pathway framework.

    Science.gov (United States)

    In order to increase the uptake and use of high throughput screening data in environmental risk assessment, it is important to establish scientifically credible links between measures of biological pathway perturbation and apical adverse outcomes in humans and wildlife. The adver...

  3. A Glider-Assisted Link Disruption Restoration Mechanism in Underwater Acoustic Sensor Networks

    Directory of Open Access Journals (Sweden)

    Zhigang Jin

    2018-02-01

    Full Text Available Underwater acoustic sensor networks (UASNs have become a hot research topic. In UASNs, nodes can be affected by ocean currents and external forces, which could result in sudden link disruption. Therefore, designing a flexible and efficient link disruption restoration mechanism to ensure the network connectivity is a challenge. In the paper, we propose a glider-assisted restoration mechanism which includes link disruption recognition and related link restoring mechanism. In the link disruption recognition mechanism, the cluster heads collect the link disruption information and then schedule gliders acting as relay nodes to restore the disrupted link. Considering the glider’s sawtooth motion, we design a relay location optimization algorithm with a consideration of both the glider’s trajectory and acoustic channel attenuation model. The utility function is established by minimizing the channel attenuation and the optimal location of glider is solved by a multiplier method. The glider-assisted restoration mechanism can greatly improve the packet delivery rate and reduce the communication energy consumption and it is more general for the restoration of different link disruption scenarios. The simulation results show that glider-assisted restoration mechanism can improve the delivery rate of data packets by 15–33% compared with cooperative opportunistic routing (OVAR, the hop-by-hop vector-based forwarding (HH-VBF and the vector based forward (VBF methods, and reduce communication energy consumption by 20–58% for a typical network’s setting.

  4. Bandwidth enhancement of wireless optical communication link using a near-infrared laser over turbid underwater channel

    KAUST Repository

    Lee, It Ee; Guo, Yujian; Ng, Tien Khee; Park, Kihong; Alouini, Mohamed-Slim; Ooi, Boon S.

    2017-01-01

    Underwater wireless optical communication (UWOC) has been widely studied as a promising alternative to establish reliable short-range marine communication links. Microscopic particulates suspended in various ocean, harbor and natural waters

  5. Active Learning in Engineering Education: A (Re)Introduction

    Science.gov (United States)

    Lima, Rui M.; Andersson, Pernille Hammar; Saalman, Elisabeth

    2017-01-01

    The informal network "Active Learning in Engineering Education" (ALE) has been promoting Active Learning since 2001. ALE creates opportunity for practitioners and researchers of engineering education to collaboratively learn how to foster learning of engineering students. The activities in ALE are centred on the vision that learners…

  6. Linked supramolecular building blocks for enhanced cluster formation

    DEFF Research Database (Denmark)

    McLellan, Ross; Palacios, Maria A.; Beavers, Christine M.

    2015-01-01

    the complex assembly process. The ability to covalently link calix[4]arenes at the methylene bridge provides significantly improved control over the introduction of different metal centres to resulting cluster motifs. Clusters assembled from bis-calix[4]-arenes and transition metal ions or 3d-4 f combinations......(Figure Presented). Methylene-bridged calix[4]arenes have emerged as extremely versatile ligand supports in the formation of new polymetallic clusters possessing fascinating magnetic properties. Metal ion binding rules established for this building block allow one to partially rationalise...

  7. BID links ferroptosis to mitochondrial cell death pathways

    Directory of Open Access Journals (Sweden)

    Sandra Neitemeier

    2017-08-01

    Full Text Available Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by erastin-mediated inhibition of the Xc- system or inhibition of glutathione peroxidase 4 (Gpx4 to an increasing number of oxidative cell death paradigms in cancer cells, neurons or kidney cells, the biochemical pathways of oxidative cell death remained largely unclear. In particular, the role of mitochondrial damage in paradigms of ferroptosis needs further investigation.In the present study, we find that erastin-induced ferroptosis in neuronal cells was accompanied by BID transactivation to mitochondria, loss of mitochondrial membrane potential, enhanced mitochondrial fragmentation and reduced ATP levels. These hallmarks of mitochondrial demise are also established features of oxytosis, a paradigm of cell death induced by Xc- inhibition by millimolar concentrations of glutamate. Bid knockout using CRISPR/Cas9 approaches preserved mitochondrial integrity and function, and mediated neuroprotective effects against both, ferroptosis and oxytosis. Furthermore, the BID-inhibitor BI-6c9 inhibited erastin-induced ferroptosis, and, in turn, the ferroptosis inhibitors ferrostatin-1 and liproxstatin-1 prevented mitochondrial dysfunction and cell death in the paradigm of oxytosis. These findings show that mitochondrial transactivation of BID links ferroptosis to mitochondrial damage as the final execution step in this paradigm of oxidative cell death. Keywords: Ferroptosis, BID, Mitochondria, CRISPR, Oxytosis, Neuronal death

  8. Pesquisaje de señales ateroscleróticas tempranas en niños de 6 a 11 años de una escuela primaria Screening for early atherosclerotic signs in children from 6 to 11 years in a primary school

    Directory of Open Access Journals (Sweden)

    Blanca Paula Morera Rojas

    2013-04-01

    Full Text Available Introducción: la señal aterosclerótica temprana ha sido identificada como una línea prioritaria de investigación para el Centro de Investigaciones y Referencia de Aterosclerosis de la Habana. Objetivo: determinar a través del pesquisaje las señales ateroscleróticas tempranas en niños de 6 a 11 años. Material y método: se realizó un estudio observacional, descriptivo y transversal en 247 niños aparentemente sanos pertenecientes al semi-internado "Salvador González Delgado" del área de salud del Policlínico "Hermanos Cruz" del municipio de Pinar del Río en el período 2009-2010. Los datos fueron almacenados en una base de datos en Microsoft Excel 2003, y procesados mediante el programa Statistica 4.2. Las variables fueron resumidas mediante frecuencias absolutas y relativas porcentuales. Resultados: se halló un 23,9 % de niños sobrepesos y un 39,3 % de obesos, el 73,3% estaban afectados por tabaquismo pasivo. Se identificaron un 24,7% de niños prehipertensos y un 3,2 % de hipertensos. Conclusiones: la presencia demostrada de señales aterogénicas tempranas asociadas al sobrepeso corporal, a la circunferencia de la cintura, a la tensión arterial y al hábito de fumar pasivo, encontrado en niños supuestamente sanos de entre 6 y 11 años por su médico de familia, sus padres y sus maestros, constituyen una señal de alarma para las autoridades de salud y obliga al pesquisaje activo y sistemático de estas señales en todos los niños.Introduction: early atherosclerotic signs have been identified as a top priority of investigation to the Research Center and Reference of Atherosclerosis in Havana Province. Objective: to screen early atherosclerotic signs in children from 6 to 11 years old.Material and Method: an observational, descriptive and cross-sectional study was conducted in 247 children apparently healthy enroll at "Salvador Gonzalez Delgado" elementary school, belonging to "Hermanos Cruz" health area in Pinar del Rio

  9. Linking effects of anthropogenic debris to ecological impacts

    Science.gov (United States)

    Browne, Mark Anthony; Underwood, A. J.; Chapman, M. G.; Williams, Rob; Thompson, Richard C.; van Franeker, Jan A.

    2015-01-01

    Accelerated contamination of habitats with debris has caused increased effort to determine ecological impacts. Strikingly, most work on organisms focuses on sublethal responses to plastic debris. This is controversial because (i) researchers have ignored medical insights about the mechanisms that link effects of debris across lower levels of biological organization to disease and mortality, and (ii) debris is considered non-hazardous by policy-makers, possibly because individuals can be injured or removed from populations and assemblages without ecological impacts. We reviewed the mechanisms that link effects of debris across lower levels of biological organization to assemblages and populations. Using plastic, we show microplastics reduce the ‘health’, feeding, growth and survival of ecosystem engineers. Larger debris alters assemblages because fishing-gear and tyres kill animals and damage habitat-forming plants, and because floating bottles facilitate recruitment and survival of novel taxa. Where ecological linkages are not known, we show how to establish hypothetical links by synthesizing studies to assess the likelihood of impacts. We also consider how population models examine ecological linkages and guide management of ecological impacts. We show that by focusing on linkages to ecological impacts rather than the presence of debris and its sublethal impacts, we could reduce threats posed by debris. PMID:25904661

  10. Deploying Linked Open Vocabulary (LOV to Enhance Library Linked Data

    Directory of Open Access Journals (Sweden)

    Oh, Sam Gyun

    2015-06-01

    Full Text Available Since the advent of Linked Data (LD as a method for building webs of data, there have been many attempts to apply and implement LD in various settings. Efforts have been made to convert bibliographic data in libraries into Linked Data, thereby generating Library Linked Data (LLD. However, when memory institutions have tried to link their data with external sources based on principles suggested by Tim Berners-Lee, identifying appropriate vocabularies for use in describing their bibliographic data has proved challenging. The objective of this paper is to discuss the potential role of Linked Open Vocabularies (LOV in providing better access to various open datasets and facilitating effective linking. The paper will also examine the ways in which memory institutions can utilize LOV to enhance the quality of LLD and LLD-based ontology design.

  11. Availability and Reliability of FSO Links Estimated from Visibility

    Directory of Open Access Journals (Sweden)

    M. Tatarko

    2012-06-01

    Full Text Available This paper is focused on estimation availability and reliability of FSO systems. Shortcut FSO means Free Space Optics. It is a system which allows optical transmission between two steady points. We can say that it is a last mile communication system. It is an optical communication system, but the propagation media is air. This solution of last mile does not require expensive optical fiber and establishing of connection is very simple. But there are some drawbacks which have a bad influence of quality of services and availability of the link. Number of phenomena in the atmosphere such as scattering, absorption and turbulence cause a large variation of receiving optical power and laser beam attenuation. The influence of absorption and turbulence can be significantly reduced by an appropriate design of FSO link. But the visibility has the main influence on quality of the optical transmission channel. Thus, in typical continental area where rain, snow or fog occurs is important to know their values. This article gives a description of device for measuring weather conditions and information about estimation of availability and reliability of FSO links in Slovakia.

  12. Action de I'AlA sur la teneur en azote total et protéinique des graines de céréales cultivées à different niveau de la capacité capillaire en eau

    Directory of Open Access Journals (Sweden)

    Wiesław Nowakowski

    2015-06-01

    Full Text Available L'action de I'AIA sur la teneur en azote total et en azote protéinique des graines du Triticum vulgare, d'Hordeum vulgare et d'Avena sativa cultivés a 30%, 60% et 90% de la capacité capillaire en eau du sable a tété étudiée au cours de trois ans (1969, 1970, 1971. La teneur en g-protéines totales liée au rendement des graines de céréales examinees a été plus élevée dans les conditions de sécheresse (30% de la capacite capillaire en eau à la suite d'un traitement auxinique. La teneur (% en azote total et proteinique ne semble pas etre tellement modifiee dans les graines de cereales à la suite d'un traitement auxinique.

  13. A novel strategy for preparing mechanically robust ionically cross-linked alginate hydrogels

    International Nuclear Information System (INIS)

    Jejurikar, Aparna; Lawrie, Gwen; Groendahl, Lisbeth; Martin, Darren

    2011-01-01

    The properties of alginate films modified using two cross-linker ions (Ca 2+ and Ba 2+ ), comparing two separate cross-linking techniques (the traditional immersion (IM) method and a new strategy in a pressure-assisted diffusion (PD) method), are evaluated. This was achieved through measuring metal ion content, water uptake and film stability in an ionic solution ([Ca 2+ ] = 2 mM). Characterization of the internal structure and mechanical properties of hydrated films were established by cryogenic scanning electron microscopy and tensile testing, respectively. It was found that gels formed by the PD technique possessed greater stability and did not exhibit any delamination after 21 day immersion as compared to gels formed by the IM technique. The Ba 2+ cross-linked gels possessed significantly higher cross-linking density as reflected in lower water content, a more dense internal structure and higher Young's modulus compared to Ca 2+ cross-linked gels. For the Ca 2+ cross-linked gels, a large improvement in the mechanical properties was observed in gels produced by the PD technique and this was attributed to thicker pore walls observed within the hydrogel structure. In contrast, for the Ba 2+ cross-linked gels, the PD technique resulted in gels that had lower tensile strength and strain energy density and this was attributed to phase separation and larger macropores in this gel.

  14. Decodificación de Movimientos Individuales de los Dedos y Agarre a Partir de Señales Mioeléctricas de Baja Densidad

    Directory of Open Access Journals (Sweden)

    John J. Villarejo Mayor

    2017-04-01

    Full Text Available Resumen: Uno de los principales retos en el diseño de prótesis de mano es poder establecer un control intuitivo que reduzca el esfuerzo del usuario durante su entrenamiento. Este trabajo presenta un esquema para identificar tareas de motricidad fina de la mano, agrupadas en movimientos de los dedos individuales y gestos para el agarre de objetos el cual se ha validado con sujetos amputados. Se han comparado diferentes métodos de selección de características y clasificadores para el reconocimiento de patrones mioeléctricos, utilizando cuatro electrodos superficiales. Las características de las señales en el dominio del tiempo y la frecuencia se han combinado con métodos no lineales basados en análisis de fractales, mostrando una diferencia significativa en comparación con los métodos expuestos en la literatura para clasificar tareas de fuerza. Los resultados con amputados mostraron una exactitud de hasta 99,4% en los movimientos individuales de los dedos, superior a la obtenida con los gestos de agarre, de hasta 93,3%. El sistema ha obtenido una tasa de acierto promedio de 86,3% utilizando máquinas de soporte vectorial (SVM, seguido muy de cerca por K-vecinos más cercanos (KNN con 83,4%. Sin embargo, KNN ha obtenido un mejor rendimiento global, debido a que es más rápido que SVM, lo que representa una ventaja para aplicaciones en tiempo real. El método aquí propuesto ofrece una mayor funcionalidad en el control de prótesis de mano, lo que mejoraría su aceptación por parte de los amputados. Abstract: Intuitive prosthesis control is one of the most important challenges in order to reduce the user effort in learning to use an artificial hand. This work presents the development of a myoelectric pattern recognition system for myoelectric weak signals able to discriminate dexterous hand movements using a reduced number of electrodes. The system was evaluated in six forearm amputees and the results were compared with the performance

  15. Advances in the ROBLINKS project on long-range shallow-water robust acoustic communciation links

    NARCIS (Netherlands)

    Gijzen, M.B. van; Walree, P.A. van; Cano, D.; Passerieux, J-M.; Waldhorst, A.; Weber, R.

    2000-01-01

    Within the ROBLINKS project waveforms and algorithms have been developed to establish robust underwater acoustic communication links with high data rates in shallow water. To evaluate the signalling schemes, a wide range of experiments has been performed during a sea trial that has been held in May

  16. Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus.

    Science.gov (United States)

    Kargutkar, Samira; Brijesh, S

    2018-04-01

    Ananas comosus (L.) Merr (Pineapple) is a tropical plant with an edible fruit. In the present study, the potential anti-inflammatory activity of A. comosus leaf extract (ALE) was studied. ALE prepared using soxhlet apparatus was subjected to preliminary qualitative phytochemical analysis and quantitative estimations of flavonoids and tannins. The components present in ALE were identified using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). Inhibitory effects of ALE on protein denaturation, and proteinase activity were assessed. Its effect on secretion of pro-inflammatory cytokines and inflammatory mediators by lipopolysaccharide-stimulated macrophages was also analyzed. Further, its anti-inflammatory activity in carrageenan-induced inflammatory rat model was examined. The preliminary qualitative phytochemical analysis revealed presence of flavonoids, phenols, tannins, carbohydrates, glycosides, and proteins in the extract. Total flavonoids and total tannins were 0.17 ± 0.006 mg equivalent of quercetin/g of ALE and 4.04 ± 0.56 mg equivalent of gallic acid/g of ALE. LC-MS analysis identified the presence of 4-hydroxy pelargonic acid, 3,4,5-trimethoxycinnamic and 4-methoxycinnamic acid, whereas GC-MS analysis identified the presence of campesterol and ethyl isoallocholate that have been previously reported for anti-inflammatory activity. ALE showed significant inhibition of protein denaturation and proteinase activity and also controlled secretion of tumour necrosis factor-α, interleukin-1β and prostaglandins, as well as the generation of reactive oxygen species by activated macrophages. ALE also significantly decreased carrageenan-induced acute paw edema. The study, therefore, identified the components present in ALE that may be responsible for its anti-inflammatory activity and thus demonstrated its potential use against acute inflammatory diseases.

  17. Brokering: a process for establishing long-term and stable links with gay male communities for research and public health education.

    Science.gov (United States)

    Silvestre, A J

    1994-02-01

    The success of efforts to prevent continued transmission of the human immunodeficiency virus (HIV) and to increase compliance with HIV prophylactic interventions among homosexual and bisexual men will depend in part on health care professionals' understanding of and ability to establish linkages with these men. In order to recruit men into a research project and an educational program, staff at the Pitt Men's Study, an epidemiological investigation of HIV infection, developed a process described here as "brokering," which was based on community organizing and marketing principles. Brokering is a dynamic process by which researchers and public health professionals exchange goods and services with formal and informal leaders of the gay community in order to establish strong, long-term linkages. To date, this process yielded 2,989 homosexual and bisexual recruits into the study, which began in 1983. After 8 years, 79% of those still alive continue to return for follow-up. While recruitment techniques will need to vary from city to city, the importance of establishing linkages with the local indigenous leadership remains of major importance.

  18. Variation in the Gender Gap in Inactive and Active Life Expectancy by the Definition of Inactivity Among Older Adults.

    Science.gov (United States)

    Malhotra, Rahul; Chan, Angelique; Ajay, Shweta; Ma, Stefan; Saito, Yasuhiko

    2016-10-01

    To assess variation in gender gap (female-male) in inactive life expectancy (IALE) and active life expectancy (ALE) by definition of inactivity. Inactivity, among older Singaporeans, was defined as follows: Scenario 1-health-related difficulty in activities of daily living (ADLs); Scenario 2-health-related difficulty in ADLs/instrumental ADLs (IADLs); Scenario 3-health-related difficulty in ADLs/IADLs or non-health-related non-performance of IADLs. Multistate life tables computed IALE and ALE at age 60, testing three hypotheses: In all scenarios, life expectancy, absolute and relative IALE, and absolute ALE are higher for females (Hypothesis 1 [H1]); gender gap in absolute and relative IALE expands, and in absolute ALE, it contracts in Scenario 2 versus 1 (Hypothesis 2 [H2]); gender gap in absolute and relative IALE decreases, and in absolute ALE, it increases in Scenario 3 versus 2 (Hypothesis 3 [H3]). H1 was supported in Scenarios 1 and 3 but not Scenario 2. Both H2 and H3 were supported. Definition of inactivity influences gender gap in IALE and ALE. © The Author(s) 2016.

  19. Photo-irradiation effects on GaAs atomic layer epitaxial growth. GaAs no genshiso epitaxial seicho ni okeru hikari reiki koka

    Energy Technology Data Exchange (ETDEWEB)

    Mashita, M.; Kawakyu, Y.; Sasaki, M.; Ishikawa, H. (Toshiba Corp., Kawasaki (Japan). Research and Development Center)

    1990-08-10

    Single atomic layer epitaxy (ALE) aims at controlling a growing film at a precision of single molecular layer. In this article, it is reported that the growth temperature range of ALE was expanded by the vertical irradiation of KrF exima laser (248 nm) onto the substrate for the ALE growth of GaAs using the metalorganic chemical vapor deposition (MOCVD) method. Thanks for the results of the above experiment, it was demonstrated that the irradiation effect was not thermal, but photochemical. In addition, this article studies the possibility of adsorption layer irradiation and surface irradiation as the photo-irradiation mechanism, and points out that coexistence of both irradiation mechanisms can be considered and, in case of exima laser, strong possibility of direct irradiation of the adsorption layer because of its high power density. Hereinafter, by using both optical growth ALE and thermal growth ALE jointly, the degree of freedom of combination of hetero ALE increases and its application to various material systems becomes possible. 16 refs., 6 figs.

  20. Operative Links

    DEFF Research Database (Denmark)

    Wistoft, Karen; Højlund, Holger

    2012-01-01

    educational goals, learning content, or value clarification. Health pedagogy is often a matter of retrospective rationalization rather than the starting point of planning. Health and risk behaviour approaches override health educational approaches. Conclusions: Operational links between health education......, health professionalism, and management strategies pose the foremost challenge. Operational links indicates cooperative levels that facilitate a creative and innovative effort across traditional professional boundaries. It is proposed that such links are supported by network structures, shared semantics...

  1. [Establishment of data warehouse of needling and moxibustion literature based on data mining].

    Science.gov (United States)

    Wang, Jian-Ling; Li, Ren-Ling; Jia, Chun-Sheng

    2012-02-01

    In order to explore the efficacy specificity and valuable rules of clinical application of needling and moxibustion methods in a large quantity of information from literature, a data warehouse needs being established. On the basis of the original databases of red-hot needle therapy and hydro-acupuncture therapy, and the newly-established databases of acupoint catgut embedding therapy, acupoint application therapy, etc., and in accordance with the characteristics of different types of needling-moxibustion literature information, databases on different subjects were established first. These subject databases constitute a general "literature data warehouse on needling moxibustion methods" composing of multi-subjects and multiple dimensions so as to discover useful regularities about clinical treatment and trials collected in the literature by using data mining techniques. In the present paper, the authors introduce the design of the data warehouse, determination of subjects, establishment of subject relations, application of the administration platform, and application of data. This data warehouse will provide a standard data representation mode, enlarge data attributes and create extensive data links among literature information in the network, and may bring us with considerable convenience and profits in clinical application decision making and scientific research about needling-moxibustion techniques.

  2. Analysis by the reductive-cleavage method of linkage positions in a polysaccharide containing 4-linked D-glucopyranosyluronic residues.

    Science.gov (United States)

    Vodonik, S A; Gray, G R

    1988-04-01

    The fate of 4-linked D-glucopyranosyluronic residues under reductive-cleavage conditions was investigated by using the Klebsiella aerogenes type 54 strain A3 capsular polysaccharide. Treatment of the fully methylated polysaccharide with triethylsilane and trimethylsilyl trifluoromethanesulfonate in dichloromethane, followed by in situ acetylation, yielded 1,5-anhydro-2,3,4,6-tetra-O-methyl-D-glucitol, 3,4-di-O-acetyl-1,5-anhydro-2,6-di-O-methyl-D-glucitol, and 3-O-acetyl-1,5-anhydro-2,4-di-O-methyl-L-fucitol, as expected, but the expected product of reductive cleavage of the 4-linked D-glucopyranosyluronic residue, namely, methyl 3-O-acetyl-2,6-anhydro-4,5-di-O-methyl-L-gulonate, was not observed. Instead, methyl 2-O-acetyl-3,6-anhydro-4,5-di-O-methyl-L-gulonate (6) was identified as the sole product of reductive cleavage of the 4-linked D-glucopyranosyluronic residue. That compound 6 arose as a result of rearrangement during reductive cleavage rather than by reductive cleavage of a 5-linked D-glucofuranosyluronic residue, was established by reductive cleavage of the fully methylated polysaccharide following reduction of its ester groups with either lithium aluminum hydride or lithium aluminum deuteride. The products of the latter reductive cleavage were the same as before, except for the absence of 6 and the presence of 4,6-di-O-acetyl-1,5-anhydro-2,3-di-O-methyl-D-glucitol, or its 6,6-dideuterio isomer. Although the reductive-cleavage technique is suitable for the direct analysis of polysaccharides containing 4-linked D-glucopyranosyluronic residues, it does not establish whether the uronic residue is a 4-linked pyranoside or a 5-linked furanoside. The expected product is, however, derived from the 4-linked D-glucopyranosyluronic residue after sequential methylation, reduction of its ester group and reductive cleavage.

  3. Link-N: The missing link towards intervertebral disc repair is species-specific.

    Directory of Open Access Journals (Sweden)

    Frances C Bach

    Full Text Available Degeneration of the intervertebral disc (IVD is a frequent cause for back pain in humans and dogs. Link-N stabilizes proteoglycan aggregates in cartilaginous tissues and exerts growth factor-like effects. The human variant of Link-N facilitates IVD regeneration in several species in vitro by inducing Smad1 signaling, but it is not clear whether this is species specific. Dogs with IVD disease could possibly benefit from Link-N treatment, but Link-N has not been tested on canine IVD cells. If Link-N appears to be effective in canines, this would facilitate translation of Link-N into the clinic using the dog as an in vivo large animal model for human IVD degeneration.This study's objective was to determine the effect of the human and canine variant of Link-N and short (s Link-N on canine chondrocyte-like cells (CLCs and compare this to those on already studied species, i.e. human and bovine CLCs. Extracellular matrix (ECM production was determined by measuring glycosaminoglycan (GAG content and histological evaluation. Additionally, the micro-aggregates' DNA content was measured. Phosphorylated (p Smad1 and -2 levels were determined using ELISA.Human (sLink-N induced GAG deposition in human and bovine CLCs, as expected. In contrast, canine (sLink-N did not affect ECM production in human CLCs, while it mainly induced collagen type I and II deposition in bovine CLCs. In canine CLCs, both canine and human (sLink-N induced negligible GAG deposition. Surprisingly, human and canine (sLink-N did not induce Smad signaling in human and bovine CLCs. Human and canine (sLink-N only mildly increased pSmad1 and Smad2 levels in canine CLCs.Human and canine (sLink-N exerted species-specific effects on CLCs from early degenerated IVDs. Both variants, however, lacked the potency as canine IVD regeneration agent. While these studies demonstrate the challenges of translational studies in large animal models, (sLink-N still holds a regenerative potential for humans.

  4. The link between off-site-emergency planning and plant-internal accident management

    Energy Technology Data Exchange (ETDEWEB)

    Braun, H.; Goertz, R.

    1995-02-01

    A variety of accident management measures has been developed and implemented in the German nuclear power plants. They constitute a fourth level of safety in the defence-in-depth concept. The containment venting system is an important example. A functioning link with well defined lines of communication between plant-internal accident management and off-site disaster emergency planning has been established.

  5. BID links ferroptosis to mitochondrial cell death pathways.

    Science.gov (United States)

    Neitemeier, Sandra; Jelinek, Anja; Laino, Vincenzo; Hoffmann, Lena; Eisenbach, Ina; Eying, Roman; Ganjam, Goutham K; Dolga, Amalia M; Oppermann, Sina; Culmsee, Carsten

    2017-08-01

    Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by erastin-mediated inhibition of the X c - system or inhibition of glutathione peroxidase 4 (Gpx4) to an increasing number of oxidative cell death paradigms in cancer cells, neurons or kidney cells, the biochemical pathways of oxidative cell death remained largely unclear. In particular, the role of mitochondrial damage in paradigms of ferroptosis needs further investigation. In the present study, we find that erastin-induced ferroptosis in neuronal cells was accompanied by BID transactivation to mitochondria, loss of mitochondrial membrane potential, enhanced mitochondrial fragmentation and reduced ATP levels. These hallmarks of mitochondrial demise are also established features of oxytosis, a paradigm of cell death induced by X c - inhibition by millimolar concentrations of glutamate. Bid knockout using CRISPR/Cas9 approaches preserved mitochondrial integrity and function, and mediated neuroprotective effects against both, ferroptosis and oxytosis. Furthermore, the BID-inhibitor BI-6c9 inhibited erastin-induced ferroptosis, and, in turn, the ferroptosis inhibitors ferrostatin-1 and liproxstatin-1 prevented mitochondrial dysfunction and cell death in the paradigm of oxytosis. These findings show that mitochondrial transactivation of BID links ferroptosis to mitochondrial damage as the final execution step in this paradigm of oxidative cell death. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  6. Imitation and speech: commonalities within Broca's area.

    Science.gov (United States)

    Kühn, Simone; Brass, Marcel; Gallinat, Jürgen

    2013-11-01

    The so-called embodiment of communication has attracted considerable interest. Recently a growing number of studies have proposed a link between Broca's area's involvement in action processing and its involvement in speech. The present quantitative meta-analysis set out to test whether neuroimaging studies on imitation and overt speech show overlap within inferior frontal gyrus. By means of activation likelihood estimation (ALE), we investigated concurrence of brain regions activated by object-free hand imitation studies as well as overt speech studies including simple syllable and more complex word production. We found direct overlap between imitation and speech in bilateral pars opercularis (BA 44) within Broca's area. Subtraction analyses revealed no unique localization neither for speech nor for imitation. To verify the potential of ALE subtraction analysis to detect unique involvement within Broca's area, we contrasted the results of a meta-analysis on motor inhibition and imitation and found separable regions involved for imitation. This is the first meta-analysis to compare the neural correlates of imitation and overt speech. The results are in line with the proposed evolutionary roots of speech in imitation.

  7. Light-induced cross-linking and post-cross-linking modification of polyglycidol.

    Science.gov (United States)

    Marquardt, F; Bruns, M; Keul, H; Yagci, Y; Möller, M

    2018-02-08

    The photoinduced radical generation process has received renewed interest due to its economic and ecological appeal. Herein the light-induced cross-linking of functional polyglycidol and its post-cross-linking modification are presented. Linear polyglycidol was first functionalized with a tertiary amine in a two-step reaction. Dimethylaminopropyl functional polyglycidol was cross-linked in a UV-light mediated reaction with camphorquinone as a type II photoinitiator. The cross-linked polyglycidol was further functionalized by quaternization with various organoiodine compounds. Aqueous dispersions of the cross-linked polymers were investigated by means of DLS and zeta potential measurements. Polymer films were evaluated by DSC and XPS.

  8. Linking effects of anthropogenic debris to ecological impacts.

    Science.gov (United States)

    Browne, Mark Anthony; Underwood, A J; Chapman, M G; Williams, Rob; Thompson, Richard C; van Franeker, Jan A

    2015-05-22

    Accelerated contamination of habitats with debris has caused increased effort to determine ecological impacts. Strikingly, most work on organisms focuses on sublethal responses to plastic debris. This is controversial because (i) researchers have ignored medical insights about the mechanisms that link effects of debris across lower levels of biological organization to disease and mortality, and (ii) debris is considered non-hazardous by policy-makers, possibly because individuals can be injured or removed from populations and assemblages without ecological impacts. We reviewed the mechanisms that link effects of debris across lower levels of biological organization to assemblages and populations. Using plastic, we show microplastics reduce the 'health', feeding, growth and survival of ecosystem engineers. Larger debris alters assemblages because fishing-gear and tyres kill animals and damage habitat-forming plants, and because floating bottles facilitate recruitment and survival of novel taxa. Where ecological linkages are not known, we show how to establish hypothetical links by synthesizing studies to assess the likelihood of impacts. We also consider how population models examine ecological linkages and guide management of ecological impacts. We show that by focusing on linkages to ecological impacts rather than the presence of debris and its sublethal impacts, we could reduce threats posed by debris. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  9. Development of research activity support system. 3. Automatic link generation/maintenance on self-evolving database; Kenkyu katsudo shien system no kaihatsu. 3. Jiko zoshokugata database deno bunsho link no jido sakusei/shufuku

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, T.; Futakata, A. [Central Research Institute of Electric Power Industry, Tokyo (Japan)

    1997-04-01

    For a coordinated task to be accomplished in an organization, documents, charts, and data produced by plural workers need to be shared by the plural workers. This information sharing setup will function more effectively when the meanings and purposes of documents, etc., are arranged in good order relative to the other documents and when they are managed as a group of documents organically linked with each other and properly updated as the task approaches completion. In the self-evolving databases proposed so far, five types of document links representing the relations between documents are automatically generated and the documents are unifiedly managed for the documents yielded by coordinated work to be arranged in a proper order. A procedure for automatically generating document links are established on the basis of information received from the document retrieval system and Lotus Notes application. In a self-evolving database, the document on either side of a link is apt to be lost due to users` moving or deleting documents. An automatic procedure is developed in this report which will enable such document links to correctly restore themselves without loss of semantic relations. 12 refs., 11 figs., 3 tabs.

  10. PRICING AND ASSESSING UNIT-LINKED INSURANCE CONTRACTS WITH INVESTMENT GUARANTEES

    Directory of Open Access Journals (Sweden)

    Ciumas Cristina

    2014-07-01

    Full Text Available One of the most interesting life insurance products to have emerged in recent years in the Romanian insurance market has been the unit-linked contract. Unit-linked insurance products are life insurance policies with investment component. A unit-linked life insurance has two important components: protection and investment. The protection component refers to the insured sum in case of the occurrence of insured risks and the investment component refers to the policyholders’ account that represents the present value of the units from the chosen investment funds. Due to the financial instability caused by the Global Crisis and the amplification of market competitiveness, insurers from international markets have started to incorporate guarantees in unit-linked products. So a unit- linked life insurance policy with an asset value guarantee is an insurance policy whose benefit payable on death or at maturity consists of the greater of some guaranteed amount and the value of the units from the investment funds. One of the most challenging issues concerns the pricing of minimum death benefit and maturity benefit guarantees and the establishing of proper reserves for these guarantees. Insurers granting guarantees of this type must estimate the cost and include the cost in the premium. An important component of the activity carried out by the insurance companies is the investment of the premiums paid by policyholders in various types of assets, in order to obtain higher yields than those guaranteed by the insurance contracts, while providing the necessary liquidity for the payment of insurance claims in case of occurrence of the assumed risks. So the guaranteed benefits can be broadly matched or immunized with various types of financial assets, especially with fixed-interest instruments. According to Romanian legislation which regulates the unit-linked life insurance market, unit-linked life insurance contracts pass most of the investment risk to the

  11. Use of link to mammography screening information and link sharing strategies

    DEFF Research Database (Denmark)

    Mukai, Thomas; Bro, Flemming; Olesen, Frede

    2011-01-01

    -43%) reported use of the link. The difference between the two strategies was 15% (95% CI: 8-22%) (Pused the link prior to the screening event, and 37% (95% CI: 30-43%) used the link afterwards. The difference was 9% (95% CI: 0-17%) (P=0.035). Among the GPs in group 1, 40% (95% CI......Introduction: The Internet is increasingly being used for disseminating knowledge in health care. Often this is done through a ‘Uniform Resource Locator’ (URL), better known as a link. There are three ways of sharing a link: verbally, in print or electronically. Furthermore, timing and exposure...... in Central Denmark Region, we constructed a website containing screening programme information for GPs. We inserted the link to this website in different media and divided the GPs into three groups: Group 1 received a letter prior to the screening event and an electronic test result after the screening...

  12. Wallops Low Elevation Link Analysis for the Constellation Launch/Ascent Links

    Science.gov (United States)

    Cheung, Keith; Ho, C.; Kantak, A.; Lee, C.; Tye, R.; Richards, E.; Sham, C.; Schlesinger, A.; Barritt, B.

    2011-01-01

    To execute the President's Vision for Space Exploration, the Constellation Program (CxP) was formed to build the next generation spacecraft Orion and launch vehicles Ares, to transport human and cargo to International Space Station (ISS), moon, and Mars. This paper focuses on the detailed link analysis for Orion/Ares s launch and ascent links with Wallops 11.3m antenna (1) Orion's Dissimilar Voice link: 10.24 Kbps, 2-way (2) Ares Developmental Flight Instrument link, 20 Mbps, downlink. Three launch trajectories are considered: TD7-E, F (Feb), and G (Aug). In certain launch scenarios, the critical events of main engine cutoff (MECO) and Separation occur during the low elevation regime of WFF s downrange -- less than 5 degree elevation angle. The goal of the study is to access if there is enough link margins for WFF to track the DV and DFI links.

  13. Glutaraldehyde Cross-Linking of TendonMechanical Effects at the Level of the Tendon Fascicle and Fibril

    DEFF Research Database (Denmark)

    Hansen, P.; Svensson, R.B.; Aagaard, P.

    2009-01-01

    were examined by atomic force microscopy. Peak forces increased from 1379 to 2622 pN while an extended Hertz fit of force-indentation data showed a 24 fold increase in Young's modulus on indentation. The effect of glutaraldehyde cross-linking on the tensile properties of a single collagen fibril......Conclusive insight into the microscopic principles that govern the strength of tendon and related connective tissues is lacking and the importance of collagen cross-linking has not been firmly established. The combined application of whole-tissue mechanical testing and atomic force spectroscopy...... allowed for a detailed characterization of the effect of cross-linking in rat-tail tendon. The cross-link inducing agent glutaraldehyde augmented the tensile strength of tendon fascicles. Stress at failure increased from 8 MPa to 39 MPa. The mechanical effects of glutaraldehyde at the tendon fibril level...

  14. Relative tracking control of constellation satellites considering inter-satellite link

    Science.gov (United States)

    Fakoor, M.; Amozegary, F.; Bakhtiari, M.; Daneshjou, K.

    2017-11-01

    In this article, two main issues related to the large-scale relative motion of satellites in the constellation are investigated to establish the Inter Satellite Link (ISL) which means the dynamic and control problems. In the section related to dynamic problems, a detailed and effective analytical solution is initially provided for the problem of satellite relative motion considering perturbations. The direct geometric method utilizing spherical coordinates is employed to achieve this solution. The evaluation of simulation shows that the solution obtained from the geometric method calculates the relative motion of the satellite with high accuracy. Thus, the proposed analytical solution will be applicable and effective. In the section related to control problems, the relative tracking control system between two satellites will be designed in order to establish a communication link between the satellites utilizing analytical solution for relative motion of satellites with respect to the reference trajectory. Sliding mode control approach is employed to develop the relative tracking control system for body to body and payload to payload tracking control. Efficiency of sliding mode control approach is compared with PID and LQR controllers. Two types of payload to payload tracking control considering with and without payload degree of freedom are designed and suitable one for practical ISL applications is introduced. Also, Fuzzy controller is utilized to eliminate the control input in the sliding mode controller.

  15. A high-speed 0.35μm CMOS optical communication link

    Science.gov (United States)

    Goosen, Marius E.; Venter, Petrus J.; du Plessis, Monuko; Bogalecki, Alfons W.; Alberts, Antonie C.; Rademeyer, Pieter

    2012-01-01

    The idea of integrating a light emitter and detector in the cost effective and mature technology which is CMOS remains an attractive one. Silicon light emitters, used in avalanche breakdown, are demonstrated to switch at frequencies above 1 GHz whilst still being electrically detected, a three-fold increase on previous reported results. Utilizing novel BEOLstack reflectors and increased array sizes have resulted in an increased power efficiency allowing multi-Mb/s data rates. In this paper we present an all-silicon optical communication link with data rates exceeding 10 Mb/s at a bit error rate of less than 10-12, representing a ten-fold increase over the previous fastest demonstrated silicon data link. Data rates exceeding 40 Mb/s are also presented and evaluated. The quality of the optical link is established using both eye diagram measurements as well as a digital communication system setup. The digital communication system setup comprises the generation of 232-1 random data, 8B/10B encoding and decoding, data recovery and the subsequent bit error counting.

  16. Usher syndrome: molecular links of pathogenesis, proteins and pathways.

    Science.gov (United States)

    Kremer, Hannie; van Wijk, Erwin; Märker, Tina; Wolfrum, Uwe; Roepman, Ronald

    2006-10-15

    Usher syndrome is the most common form of deaf-blindness. The syndrome is both clinically and genetically heterogeneous, and to date, eight causative genes have been identified. The proteins encoded by these genes are part of a dynamic protein complex that is present in hair cells of the inner ear and in photoreceptor cells of the retina. The localization of the Usher proteins and the phenotype in animal models indicate that the Usher protein complex is essential in the morphogenesis of the stereocilia bundle in hair cells and in the calycal processes of photoreceptor cells. In addition, the Usher proteins are important in the synaptic processes of both cell types. The association of other proteins with the complex indicates functional links to a number of basic cell-biological processes. Prominently present is the connection to the dynamics of the actin cytoskeleton, involved in cellular morphology, cell polarity and cell-cell interactions. The Usher protein complex can also be linked to the cadherins/catenins in the adherens junction-associated protein complexes, suggesting a role in cell polarity and tissue organization. A third link can be established to the integrin transmembrane signaling network. The Usher interactome, as outlined in this review, participates in pathways common in inner ear and retina that are disrupted in the Usher syndrome.

  17. Note despre numele proprii în traducerile românești din secolul al XVIII-lea ale Vieții lui Petru (de Antonio Catiforo

    Directory of Open Access Journals (Sweden)

    Cristian Ungureanu

    2017-01-01

    Full Text Available Vita di Pietro este o lucrare alcătuită de grecul Antonio Catiforo în limba italiană, publicată la Veneția, în 1736; o versiune a sa în limba greacă a fost publicată tot la Veneția, un an mai tîrziu, de către Alexandros Kankellarios. Lucrarea conține șase cărți și sintetizează informațiile oferite de surse referitoare la epoca și personalitatea țarului rus. În română, ea a cunoscut mai multe traduceri la jumătatea și în a doua perioadă a secolului al XVIII-lea, în toate cele trei provincii românești. Numărul mare de copii arată interesul de care s-a bucurat această lucrare în epocă.Articolul de față prezintă cîteva particularități ale transferului numelor proprii din limba-sursă în limba-țintă. Am analizat patru tipuri de nume proprii: horonimul Moscovia și etnonimul aferent, horonime occidentale, antroponime rusești, antroponime de alte origini, urmărind felul în care traducătorii se raportează la sursă și diferențele dintre versiuni din acest punct de vedere.

  18. Linking open vocabularies

    CERN Document Server

    Greifender, Elke; Seadle, Michael

    2013-01-01

    Linked Data (LD), Linked Open Data (LOD) and generating a web of data, present the new knowledge sharing frontier. In a philosophical context, LD is an evolving environment that reflects humankinds' desire to understand the world by drawing on the latest technologies and capabilities of the time. LD, while seemingly a new phenomenon did not emerge overnight; rather it represents the natural progression by which knowledge structures are developed, used, and shared. Linked Open Vocabularies is a significant trajectory of LD. Linked Open Vocabularies targets vocabularies that have traditionally b

  19. Infección por el virus de la Lengua azul: activación de señales celulares que inducen apoptosis Bluetongue virus infection: signaling pathway activated during apoptosis

    Directory of Open Access Journals (Sweden)

    E. Mortola

    2009-09-01

    Full Text Available El virus de la Lengua azul (VLA es un ARN virus de doble cadena que induce apoptosis tanto en cultivos celulares como en tejidos blanco. Con el fin de dilucidar el mecanismo de apoptosis en la infección por el VLA, en el presente trabajo examinamos en detalle, por la técnica de Western blot, las señales celulares de caspasas, Bax, citocromo c, Smac/DIABLO y factor nuclear kappa B (NF-kB que se activan en la infección viral. Hemos comprobado que luego de la infección in vitro con el VLA, se detectó la activación de la caspasa 8 y con ello el mecanismo extrínseco de la apoptosis. También detectamos por primera vez no sólo la activación de miembros de la familia Bcl-2 (Bax, sino también la liberación del citocromo c y la proteína Smac/DIABLO, confirmando que en la infección por el VLA está involucrado el mecanismo secuencial intrínseco de la apoptosis. Asimismo, demostramos que la infección por el VLA activa el NF-kB y que la apoptosis es sustancialmente reducida mediante la inhibición del mismo. La activación de las señales celulares tales como Bax, citocromo c, Smac/DIABLO y NF-kB presentados en este trabajo, esclarecen los mecanismos apoptóticos durante la infección por el VLA para una mayor comprensión del papel primario que juega la apoptosis en la patogénesis del virus.Bluetongue (BTV is a double-stranded RNA virus that induces apoptosis both in mammalian cell cultures and in target tissues. To elucidate the apoptosis pathways in BTV infection, we have examined in detail the apoptosis mechanism by examination of caspases, Bax, cytochrome c, Smac/DIABLO and NF-kB signalling pathways. In this report, after cell infection with BTV, the activation of caspase 8 was detected, proving the extrinsic receptor binding apoptotic pathway. Apoptosis followed a sequential pathway involving the detection of activated Bcl-2 family members. Furthermore, its translocation to the mitochondria, as well as the release of cytochrome c and

  20. Differences in effectiveness of the active living every day program for older adults with arthritis.

    Science.gov (United States)

    Sperber, Nina R; Allen, Kelli D; Devellis, Brenda M; Devellis, Robert F; Lewis, Megan A; Callahan, Leigh F

    2013-10-01

    The authors explored whether demographic and psychosocial variables predicted differences in physical activity for participants with arthritis in a trial of Active Living Every Day (ALED). Participants (N = 280) from 17 community sites were randomized into ALED or usual care. The authors assessed participant demographic characteristics, self-efficacy, outcome expectations, pain, fatigue, and depressive symptoms at baseline and physical activity frequency at 20-wk follow-up. They conducted linear regression with interaction terms (Baseline Characteristic × Randomization Group). Being female (p ≤ .05), less depressed (p ≤ .05), or younger (p ≤ .10) was associated with more frequent posttest physical activity for ALED participants than for those with usual care. Higher education was associated with more physical activity for both ALED and usual-care groups. ALED was particularly effective for female, younger, and less depressed participants. Further research should determine whether modifications could produce better outcomes in other subgroups.

  1. Effect of Link Flexibility on tip position of a single link robotic arm

    Science.gov (United States)

    Madhusudan Raju, E.; Siva Rama Krishna, L.; Mouli, Y. Sharath Chandra; Nageswara Rao, V.

    2015-12-01

    The flexible robots are widely used in space applications due to their quick response, lower energy consumption, lower overall mass and operation at high speed compared to conventional industrial rigid link robots. These robots are inherently flexible, so that the kinematics of flexible robots can't be solved with rigid body assumptions. The flexibility in links and joints affects end-point positioning accuracy of the robot. It is important to model the link kinematics with precision which in turn simplifies modelling of dynamics of flexible robots. The main objective of this paper is to evaluate the effect of link flexibility on a tip position of a single link robotic arm for a given motion. The joint is assumed to be rigid and only link flexibility is considered. The kinematics of flexible link problem is evaluated by Assumed Modes Method (AMM) using MAT LAB Programming. To evaluate the effect of link flexibility (with and without payload) of robotic arm, the normalized tip deviation is found for flexible link with respect to a rigid link. Finally, the limiting inertia for payload mass is found if the allowable tip deviation is 5%.

  2. Avaliação de alunos e professores acerca do software "Sinais Vitais" Evaluación de estudiantes y profesores acerca del software "señales vitales" Evaluation of students and teachers concerning the "vital signs" software

    Directory of Open Access Journals (Sweden)

    Marcos Venícios de Oliveira Lopes

    2004-12-01

    Full Text Available Este artigo teve por objetivo levantar as opiniões de alunos e professores sobre o software "Sinais Vitais". O trabalho foi desenvolvido no Departamento de Enfermagem da Universidade Federal do Ceará. Trabalhou-se com um total de seis alunos e três professores, os quais foram submetidos a uma entrevista após a utilização do software. As entrevistas geraram dez categorias, as quais foram separadas em dois temas: Características que estimularam a utilização do software "Sinais Vitais" e Software educacionalmente correto. Concluiu-se que os professores valorizaram a correção do conteúdo, enquanto os alunos enfocaram mais a dinâmica do programa.Este artículo tuvo por objetivo levantar las opiniones de alumnos y profesores sobre el software "Señales Vitales". El trabajo fue desarrollado en el Departamento de Enfermería de la Universidad Federal de Ceará. Se trabajó con un total de 6 alumnos y 3 profesores, los cuales fueron sometidos a una entrevista después de la utilización del software. Las entrevistas generaron 10 categorías, que fueron separadas en dos temas: Características que estimularon la utilización del software "Señales Vitales"; y software educativamente correcto. Se concluyó que los profesores valoraron la corrección del contenido, mientras que los alumnos enfocaron más la dinámica del programa.This article had for objective to get students' and teacher's opinions about "Vital Signals" software. The investigation was developed in the Nursing Department of the Federal University of Ceará. The sample population was a total of 6 students and 3 teachers, who were submitted to an interview after using the software. The interviews generated 10 categories, which were separated in two themes: Features which stimulated the use of the "Vital Signals" software; and software educationally correct. The results showed that the teachers valued the correction of the content, while the students focused more on the dynamics

  3. Linking Data for Mothers and Babies in De-Identified Electronic Health Data.

    Science.gov (United States)

    Harron, Katie; Gilbert, Ruth; Cromwell, David; van der Meulen, Jan

    2016-01-01

    Linkage of longitudinal administrative data for mothers and babies supports research and service evaluation in several populations around the world. We established a linked mother-baby cohort using pseudonymised, population-level data for England. Retrospective linkage study using electronic hospital records of mothers and babies admitted to NHS hospitals in England, captured in Hospital Episode Statistics between April 2001 and March 2013. Of 672,955 baby records in 2012/13, 280,470 (42%) linked deterministically to a maternal record using hospital, GP practice, maternal age, birthweight, gestation, birth order and sex. A further 380,164 (56%) records linked using probabilistic methods incorporating additional variables that could differ between mother/baby records (admission dates, ethnicity, 3/4-character postcode district) or that include missing values (delivery variables). The false-match rate was estimated at 0.15% using synthetic data. Data quality improved over time: for 2001/02, 91% of baby records were linked (holding the estimated false-match rate at 0.15%). The linked cohort was representative of national distributions of gender, gestation, birth weight and maternal age, and captured approximately 97% of births in England. Probabilistic linkage of maternal and baby healthcare characteristics offers an efficient way to enrich maternity data, improve data quality, and create longitudinal cohorts for research and service evaluation. This approach could be extended to linkage of other datasets that have non-disclosive characteristics in common.

  4. Link reliability based hybrid routing for tactical mobile ad hoc network

    Institute of Scientific and Technical Information of China (English)

    Xie Xiaochuan; Wei Gang; Wu Keping; Wang Gang; Jia Shilou

    2008-01-01

    Tactical mobile ad hoc network (MANET) is a collection of mobile nodes forming a temporary network,without the aid of pre-established network infrastructure. The routing protocol has a crucial impact on the networkperformance in battlefields. Link reliability based hybrid routing (LRHR) is proposed, which is a novel hybrid routing protocol, for tactical MANET. Contrary to the traditional single path routing strategy, multiple paths are established between a pair of source-destination nodes. In the hybrid routing strategy, the rate of topological change provides a natural mechanism for switching dynamically between table-driven and on-demand routing. The simulation results indicate that the performances of the protocol in packet delivery ratio, routing overhead, and average end-to-end delay are better than the conventional routing protocol.

  5. Linked Ocean Data

    Science.gov (United States)

    Leadbetter, Adam; Arko, Robert; Chandler, Cynthia; Shepherd, Adam

    2014-05-01

    "Linked Data" is a term used in Computer Science to encapsulate a methodology for publishing data and metadata in a structured format so that links may be created and exploited between objects. Berners-Lee (2006) outlines the following four design principles of a Linked Data system: Use Uniform Resource Identifiers (URIs) as names for things. Use HyperText Transfer Protocol (HTTP) URIs so that people can look up those names. When someone looks up a URI, provide useful information, using the standards (Resource Description Framework [RDF] and the RDF query language [SPARQL]). Include links to other URIs so that they can discover more things. In 2010, Berners-Lee revisited his original design plan for Linked Data to encourage data owners along a path to "good Linked Data". This revision involved the creation of a five star rating system for Linked Data outlined below. One star: Available on the web (in any format). Two stars: Available as machine-readable structured data (e.g. An Excel spreadsheet instead of an image scan of a table). Three stars: As two stars plus the use of a non-proprietary format (e.g. Comma Separated Values instead of Excel). Four stars: As three stars plus the use of open standards from the World Wide Web Commission (W3C) (i.e. RDF and SPARQL) to identify things, so that people can point to your data and metadata. Five stars: All the above plus link your data to other people's data to provide context Here we present work building on the SeaDataNet common vocabularies served by the NERC Vocabulary Server, connecting projects such as the Rolling Deck to Repository (R2R) and the Biological and Chemical Oceanography Data Management Office (BCO-DMO) and other vocabularies such as the Marine Metadata Interoperability Ontology Register and Repository and the NASA Global Change Master Directory to create a Linked Ocean Data cloud. Publishing the vocabularies and metadata in standard RDF XML and exposing SPARQL endpoints renders them five-star Linked

  6. Open Innovation or Innovation in the Open? An Exploration of the Strategy–Innovation Link in Five Scale-Intensive Services

    OpenAIRE

    Breunig, Karl Joachim; Aas, Tor Helge; Hydle, Katja Maria

    2016-01-01

    This chapter explores the strategy–innovation link in open service innovations. The increased attention to the role of the firm's external environment on innovation has important implications for strategy. However, our literature review reveals that the strategy–innovation link is ambiguously treated in extant theory, especially with respect to open- and service-innovations. Therefore, we inductively explore innovation practices in five large scale-intensive service firms to establish the lin...

  7. Multiparametric classification links tumor microenvironments with tumor cell phenotype.

    Directory of Open Access Journals (Sweden)

    Bojana Gligorijevic

    2014-11-01

    Full Text Available While it has been established that a number of microenvironment components can affect the likelihood of metastasis, the link between microenvironment and tumor cell phenotypes is poorly understood. Here we have examined microenvironment control over two different tumor cell motility phenotypes required for metastasis. By high-resolution multiphoton microscopy of mammary carcinoma in mice, we detected two phenotypes of motile tumor cells, different in locomotion speed. Only slower tumor cells exhibited protrusions with molecular, morphological, and functional characteristics associated with invadopodia. Each region in the primary tumor exhibited either fast- or slow-locomotion. To understand how the tumor microenvironment controls invadopodium formation and tumor cell locomotion, we systematically analyzed components of the microenvironment previously associated with cell invasion and migration. No single microenvironmental property was able to predict the locations of tumor cell phenotypes in the tumor if used in isolation or combined linearly. To solve this, we utilized the support vector machine (SVM algorithm to classify phenotypes in a nonlinear fashion. This approach identified conditions that promoted either motility phenotype. We then demonstrated that varying one of the conditions may change tumor cell behavior only in a context-dependent manner. In addition, to establish the link between phenotypes and cell fates, we photoconverted and monitored the fate of tumor cells in different microenvironments, finding that only tumor cells in the invadopodium-rich microenvironments degraded extracellular matrix (ECM and disseminated. The number of invadopodia positively correlated with degradation, while the inhibiting metalloproteases eliminated degradation and lung metastasis, consistent with a direct link among invadopodia, ECM degradation, and metastasis. We have detected and characterized two phenotypes of motile tumor cells in vivo, which

  8. [The impact of hypertension on active life expectancy among senior citizens of Beijing].

    Science.gov (United States)

    Zhang, Zhong-ying; Tang, Zhe; Feng, Ming

    2010-07-01

    The aim of the study is to explore the influence of hypertension on life expectancy (LE), active life expectancy (ALE) and active life expectancy/life expectancy (ALE/LE) among senior citizens in Beijin. The sample derived from Beijing multidimensional longitudinal study on aging, baseline survey consisted of 1847 elderly people aged 60 years and over dwelling in the communities from one urban district (Xuanwu), one suburban country (Daxing) and one mountainous country (Huairou) in Beijing, 2004. Cluster, stratified and randomly selected sampling technique was used and a follow-up program was carried out in 2007. The subjects were invited to fill in questionnaires at home through well-trained interviewers, together with medical history of hypertension and repeated blood pressure measurements adopted. The state of activity was defined according to whether they could perform activities of daily life (ADL). IMaCH software for multi-state life table method was used to calculate the life expectancy (LE), active life expectancy (ALE) and active life expectancy/life expectancy (ALE/LE) in people with hypertension and normal blood tension, as well as on those people with hypertension with or without cardio-cerebral disease. The study manifested that hypertensives were associated with the reduction of LE, ALE and ALE/LE compared to the normotensives. The ALE/LE was descending along with ageing, and the speed of reduction was much faster in the hypertensive group, especially within senile population. LE, ALE and LE/LE among the hypertensives with cardio-cerebral vascular diseases were shorter than the hypertensives without the disease. Difference in ALE/LE was striking in people with virile senility. Hypertension remarkably impacted the active life expectancy on senior citizens living in Beijing, especially for elderly. Hypertensives with cardio-cerebral vascular diseases exerted further influence on active life expectancy, particularly among population of virile senility

  9. Visualisierung von typisierten Links in Linked Data

    Directory of Open Access Journals (Sweden)

    Georg Neubauer

    2017-09-01

    Full Text Available Das Themengebiet der Arbeit behandelt Visualisierungen von typisierten Links in Linked Data. Die wissenschaftlichen Gebiete, die im Allgemeinen den Inhalt des Beitrags abgrenzen, sind das Semantic Web, das Web of Data und Informationsvisualisierung. Das Semantic Web, das von Tim Berners Lee 2001 erfunden wurde, stellt eine Erweiterung zum World Wide Web (Web 2.0 dar. Aktuelle Forschungen beziehen sich auf die Verknüpfbarkeit von Informationen im World Wide Web. Um es zu ermöglichen, solche Verbindungen wahrnehmen und verarbeiten zu können sind Visualisierungen die wichtigsten Anforderungen als Hauptteil der Datenverarbeitung. Im Zusammenhang mit dem Sematic Web werden Repräsentationen von zuhammenhängenden Informationen anhand von Graphen gehandhabt. Der Grund des Entstehens dieser Arbeit ist in erster Linie die Beschreibung der Gestaltung von Linked Data-Visualisierungskonzepten, deren Prinzipien im Rahmen einer theoretischen Annäherung eingeführt werden. Anhand des Kontexts führt eine schrittweise Erweiterung der Informationen mit dem Ziel, praktische Richtlinien anzubieten, zur Vernetzung dieser ausgearbeiteten Gestaltungsrichtlinien. Indem die Entwürfe zweier alternativer Visualisierungen einer standardisierten Webapplikation beschrieben werden, die Linked Data als Netzwerk visualisiert, konnte ein Test durchgeführt werden, der deren Kompatibilität zum Inhalt hatte. Der praktische Teil behandelt daher die Designphase, die Resultate, und zukünftige Anforderungen des Projektes, die durch die Testung ausgearbeitet wurden.

  10. Entropy-Based Model for Interpreting Life Systems in Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Guo-lian Kang

    2008-01-01

    Full Text Available Traditional Chinese medicine (TCM treats qi as the core of the human life systems. Starting with a hypothetical correlation between TCM qi and the entropy theory, we address in this article a holistic model for evaluating and unveiling the rule of TCM life systems. Several new concepts such as acquired life entropy (ALE, acquired life entropy flow (ALEF and acquired life entropy production (ALEP are propounded to interpret TCM life systems. Using the entropy theory, mathematical models are established for ALE, ALEF and ALEP, which reflect the evolution of life systems. Some criteria are given on physiological activities and pathological changes of the body in different stages of life. Moreover, a real data-based simulation shows life entropies of the human body with different ages, Cold and Hot constitutions and in different seasons in North China are coincided with the manifestations of qi as well as the life evolution in TCM descriptions. Especially, based on the comparative and quantitative analysis, the entropy-based model can nicely describe the evolution of life entropies in Cold and Hot individuals thereby fitting the Yin–Yang theory in TCM. Thus, this work establishes a novel approach to interpret the fundamental principles in TCM, and provides an alternative understanding for the complex life systems.

  11. Survey of Revegetated Areas on the Fitzner/Eberhardt Arid Lands Ecology Reserve: Status and Initial Monitoring Results

    Energy Technology Data Exchange (ETDEWEB)

    Downs, Janelle L.; Link, Steven O.; Rozeboom, Latricia L.; Durham, Robin E.; Cruz, Rico O.; Mckee, Sadie A.

    2011-09-01

    During 2010, the U.S. Department of Energy (DOE), Richland Operations Office removed a number of facilities and debris from the Fitzner/Eberhardt Arid Lands Ecology Reserve (ALE), which is part of the Hanford Reach National Monument (HRNM). Revegetation of disturbed sites is necessary to stabilize the soil, reduce invasion of these areas by exotic weeds, and to accelerate re-establishment of native plant communities. Seven revegetation units were identified on ALE based on soils and potential native plant communities at the site. Native seed mixes and plant material were identified for each area based on the desired plant community. Revegetation of locations affected by decommissioning of buildings and debris removal was undertaken during the winter and early spring of 2010 and 2011, respectively. This report describes both the details of planting and seeding for each of the units, describes the sampling design for monitoring, and summarizes the data collected during the first year of monitoring. In general, the revegetation efforts were successful in establishing native bunchgrasses and shrubs on most of the sites within the 7 revegetation units. Invasion of the revegetation areas by exotic annual species was minimal for most sites, but was above initial criteria in 3 areas: the Hodges Well subunit of Unit 2, and Units 6 and 7.

  12. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    DEFF Research Database (Denmark)

    Ngo, Trung Dung

    2012-01-01

    of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link...... optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm...

  13. Evaluation of Average Life Expectancy of Exposed Individuals and their offspring: Population Genetic Approach

    International Nuclear Information System (INIS)

    Telnov, V. I.; Sotnik, N. V.

    2004-01-01

    Average life expectancy (ALE) is a significant integrating indicator of the population health. It can be affected by many factors such as radiation and hereditary ones. A population-genetic analysis of the average life expectancy (ALE) was performed for nuclear workers at the Mayak Production. Association exposed to external and internal radiation over a wide dose range and their offspring. A methodical approach was proposed to determine ALE for individuals with different genotypes and estimate ALE in the population based on genotype distribution. The analysis of a number of genetic markers revealed significant changes in the age-specific pattern of the Hp types in workers over 60 years. Such changes were caused by both radiation and non-radiation (cardiovascular pathology) factors. In the first case ALE decreased as Hp 1-1 > Hp 2-2> Hp2-1 (radiation). In the second case, it decreased as Hp 1-1> Hp-2-1> Hp2-2 (non-radiation). analysis of genetic markers in the workers offspring indicated significant shifts in distribution of the Hp types, especially an increase in the proportion of Hp 2-2 at doses from external γ-rays over 200 cGy to parents by the time of conception. Based on the non-radiation genotype differences in ALE in this group of offspring, the preliminary calculation of ALE was carried out, which indicated its reduction by 0.52 years in comparison with the control. (Author) 21 refs

  14. Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates.

    Science.gov (United States)

    Ali, Khursheed; Dwivedi, Sourabh; Azam, Ameer; Saquib, Quaiser; Al-Said, Mansour S; Alkhedhairy, Abdulaziz A; Musarrat, Javed

    2016-06-15

    ZnO nanoparticles (ZnONPs) were synthesised through a simple and efficient biogenic synthesis approach, exploiting the reducing and capping potential of Aloe barbadensis Miller (A. vera) leaf extract (ALE). ALE-capped ZnO nanoparticles (ALE-ZnONPs) were characterized using UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM) analyses. XRD analysis provided the average size of ZnONPs as 15 nm. FTIR spectral analysis suggested the role of phenolic compounds, terpenoids and proteins present in ALE, in nucleation and stability of ZnONPs. Flow cytometry and atomic absorption spectrophotometry (AAS) data analyses revealed the surface binding and internalization of ZnONPs in Gram +ve (Staphylococcus aureus) and Gram -ve (Escherichia coli) cells, respectively. Significant antibacterial activity of ALE-ZnONPs was observed against extended spectrum beta lactamases (ESBL) positive E. coli, Pseudomonas aeruginosa, and methicillin resistant S. aureus (MRSA) clinical isolates exhibiting the MIC and MBC values of 2200, 2400 μg/ml and 2300, 2700 μg/ml, respectively. Substantial inhibitory effects of ALE-ZnONPs on bacterial growth kinetics, exopolysaccharides and biofilm formation, unequivocally suggested the antibiotic and anti-biofilm potential. Overall, the results elucidated a rapid, environmentally benign, cost-effective, and convenient method for ALE-ZnONPs synthesis, for possible applications as nanoantibiotics or drug carriers. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Ecosystem microbiology of coral reefs: linking genomic, metabolomic, and biogeochemical dynamics from animal symbioses to reefscape processes

    NARCIS (Netherlands)

    Wegley Kelly, L.; Haas, A.F.; Nelson, C.E.

    2018-01-01

    Over the past 2 decades, molecular techniques have established the critical role of both free-living and host-associated microbial partnerships in the environment. Advancing research to link microbial community dynamics simultaneously to host physiology and ecosystem biogeochemistry is required to

  16. Assessment of UVA-Riboflavin Corneal Cross-Linking Using Small Amplitude Oscillatory Shear Measurements.

    Science.gov (United States)

    Aslanides, Ioannis M; Dessi, Claudia; Georgoudis, Panagiotis; Charalambidis, Georgios; Vlassopoulos, Dimitris; Coutsolelos, Athanassios G; Kymionis, George; Mukherjee, Achyut; Kitsopoulos, Theofanis N

    2016-04-01

    The effect of ultraviolet (UV)-riboflavin cross-linking (CXL) has been measured primarily using the strip extensometry technique. We propose a simple and reliable methodology for the assessment of CXL treatment by using an established rheologic protocol based on small amplitude oscillatory shear (SAOS) measurements. It provides information on the average cross-link density and the elastic modulus of treated cornea samples. Three fresh postmortem porcine corneas were used to study the feasibility of the technique, one serving as control and two receiving corneal collagen cross-linking treatment. Subsequently, five pairs of fresh postmortem porcine corneas received corneal collagen cross-linking treatment with riboflavin and UVA-irradiation (370 nm; irradiance of 3 mW/cm2) for 30 minutes (Dresden protocol); the contralateral porcine corneas were used as control samples. After the treatment, the linear viscoelastic moduli of the corneal samples were measured using SAOS measurements and the average cross-linking densities extracted. For all cases investigated, the dynamic moduli of the cross-linked corneas were higher compared to those of the corresponding control samples. The increase of the elastic modulus of the treated samples was between 122% and 1750%. The difference was statistically significant for all tested samples (P = 0.018, 2-tailed t-test). We report a simple and accurate methodology for quantifying the effects of cross-linking on porcine corneas treated with the Dresden protocol by means of SAOS measurements in the linear regime. The measured dynamic moduli, elastic and viscous modulus, represent the energy storage and energy dissipation, respectively. Hence, they provide a means to assess the changing physical properties of the cross-linked collagen networks after CXL treatment.

  17. Wallops' Low Elevation Link Analysis for the Constellation Launch/Ascent Links

    Science.gov (United States)

    Cheung, Kar-Ming; Ho, Christian; Kantak, Anil; Lee, Charles; Tye, Robert; Richards, Edger; Sham, Catherine; Schlesinger, Adam; Barritt, Brian

    2011-01-01

    Prior to the redirection of the Constellation Program, the Wallops 11.3-meter ground station was tasked to support the Orion's Dissimilar Voice (DV) link and the Ares's Development Flight Instrument (DFI) link. Detailed analysis of the launch trajectories indicates that during the launch and ascent operation, the critical events of Orion-Ares main engine cut off (MECO) and Separation occur at low elevation angle. We worked with engineers from both Wallops Flight Facility (WFF) and Johnson Space Center (JSC) to perform an intensive measurement and link analysis campaign on the DV and DFI links. The main results were as follows: (1) The DV links have more than 3 dB margin at MECO and Separation. (2) The DFI links have 0 dB margin at Separation during certain weather condition in summer season. (3) Tropospheric scintillation loss is the major impairment at low elevation angle. (4) The current scintillation models in the Recommendation ITU-R P.618 (Propagation data and prediction methods required for the design of Earth-space telecommunication systems), which are based on limited experimental and theoretical work, exhibit idiosyncratic behaviors. We developed an improved model based on the measurements of recent Shuttle mission launch and ascent links and the ITU propagation data. (5) Due to the attitude uncertainty of the Orion-Ares stack, the high dynamics of the launch and ascent trajectory, and the irregularity of the Orion and Ares antenna patterns, we employed new link analysis approach to model the spacecraft antenna gain. In this paper we discuss the details of the aforementioned results.

  18. Khovanov homology of graph-links

    Energy Technology Data Exchange (ETDEWEB)

    Nikonov, Igor M [M. V. Lomonosov Moscow State University, Faculty of Mechanics and Mathematics, Moscow (Russian Federation)

    2012-08-31

    Graph-links arise as the intersection graphs of turning chord diagrams of links. Speaking informally, graph-links provide a combinatorial description of links up to mutations. Many link invariants can be reformulated in the language of graph-links. Khovanov homology, a well-known and useful knot invariant, is defined for graph-links in this paper (in the case of the ground field of characteristic two). Bibliography: 14 titles.

  19. The Link Class Project: Collaborative virtual teams between Peru and The Netherlands

    OpenAIRE

    Mariella Olivos Rossini; Sandra Rincón; Anne-Francoise Rutkowski

    2015-01-01

    The Link Class Project presented in this article provides an example of established collaborative group activities to negotiate and build a report together in virtual teams composed of students at Universidad ESAN, Lima (Peru) and Tilburg University, Tilburg (Netherlands). It further analyzes the effects of a campus based internationalization strategy supported by the use of technology. Based on previous experiences with virtual classrooms, the authors adhere to the ancient Chinese philosophe...

  20. Establishment of prairies

    International Nuclear Information System (INIS)

    Lotero Cadavid, J.

    2001-01-01

    Are analyzed the establishment of prairies, such as the selection of the species, the factors of the environment, the impact in the establishment and forage production and its relation to the soil, the precipitation, the temperature, the light and the biotic factors. It is indicated that the selection of the species to settle down, is directly related with the climate and the soil and they group to be tolerant to drought, tolerant to flood soils, tolerant to humid soils, tolerant to soils very acids, moderately acids and saline. It is noticed that a bad establishment of the grasses can be due to the bad quality of the seed, a temperature and unfavorable humidity can cause low germination; equally seeds planted very deeply in heavy soils with excess of humidity. Considerations are made about the establishment and growth of the prairies in connection with the germination, cultures, sowing density and sowing on time, as well as for the soil preparation, the sowing in terrestrial mechanic and non mechanic and the use of cultivations forms of low cost and fertilization systems; equally the establishment of leguminous in mixture with gramineous, the renovation of prairies and the establishment of pastures

  1. Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat.

    Science.gov (United States)

    Magielse, Joanna; Verlaet, Annelies; Breynaert, Annelies; Keenoy, Begoña Manuel Y; Apers, Sandra; Pieters, Luc; Hermans, Nina

    2014-01-01

    The in vivo antioxidant activity of a quantified leaf extract of Cynara scolymus (artichoke) was studied. The aqueous artichoke leaf extract (ALE), containing 1.5% caffeoylquinic acid with chlorogenic acid being most abundant (0.30%), and luteolin-7-O-glucoside as major flavonoid (0.15%), was investigated by evaluating the effect on different oxidative stress biomarkers, after 3 wk oral supplementation in the streptozotocin-induced diabetic rat model. Apart from two test groups (0.2 g ALE/kg BW/day and 1 g ALE/kg BW/day, where BW is body weight), a healthy control group, untreated oxidative stress group, and vitamin E treated group (positive control) were included. A 0.2 g/kg BW/day of ALE decreased oxidative stress: malondialdehyde and 8-hydroxydeoxyguanosine levels significantly diminished, whereas erythrocyte glutathione levels significantly increased. A 1.0 g/kg BW/day ALE did not show higher antioxidant activity. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Irradiation studies of multimode optical fibres for use in ATLAS front-end links

    International Nuclear Information System (INIS)

    Mahout, G.; Pearce, M.; Andrieux, M-L.; Arvidsson, C-B.; Charlton, D.G.; Dinkespiler, B.; Dowell, J.D.; Gallin-Martel, L.; Homer, R.J.; Jovanovic, P.; Kenyon, I.R.; Kuyt, G.; Lundquist, J.; Mandic, I.; Martin, O.; Shaylor, H.R.; Stroynowski, R.; Troska, J.; Wastie, R.L.; Weidberg, A.R.; Wilson, J.A.; Ye, J.

    2000-01-01

    The radiation tolerance of three multimode optical fibres has been investigated to establish their suitability for the use in the front-end data links of the ATLAS experiment. Both gamma and neutron irradiation studies are reported. A step-index fibre with a pure silica core showed an induced attenuation of ∼0.05 dB/m at 330 kGy(Si) and 1x10 15 n(1 MeV Si)/cm 2 and is suitable for use with the inner detector links which operate at 40-80 Mb/s. A graded-index fibre with a predominantly germanium-doped core exhibits an induced attenuation of ∼0.1 dB/m at 800 Gy(Si) and 2x10 13 n(1 MeV Si)/cm 2 and is suitable for the calorimeter links which operate at 1.6 Gb/s. Measurements of the dose rate dependence of the induced attenuation indicate that the attenuation in ATLAS will be lower

  3. Alpha thalassaemia-mental retardation, X linked

    Directory of Open Access Journals (Sweden)

    Gibbons Richard

    2006-05-01

    Full Text Available Abstract X-linked alpha thalassaemia mental retardation (ATR-X syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients present with facial hypotonia and a characteristic mouth. Genital abnormalities are observed in 80% of children and range from undescended testes to ambiguous genitalia. Alpha-thalassaemia is not always present. This syndrome is X-linked recessive and results from mutations in the ATRX gene. This gene encodes the widely expressed ATRX protein. ATRX mutations cause diverse changes in the pattern of DNA methylation at heterochromatic loci but it is not yet known whether this is responsible for the clinical phenotype. The diagnosis can be established by detection of alpha thalassaemia, identification of ATRX gene mutations, ATRX protein studies and X-inactivation studies. Genetic counselling can be offered to families. Management is multidisciplinary: young children must be carefully monitored for gastro-oesophageal reflux as it may cause death. A number of individuals with ATR-X are fit and well in their 30s and 40s.

  4. Gene distribution of ABO blood type system on the Dengue Hemorrhagic Fever (DHF) patients in the working area of Puskesmas Bonto Bangun, District of Rilau Ale, Bulukumba

    Science.gov (United States)

    Sjafaraenan; Alvionita, D. N.; Agus, R.; Sabran, A.

    2018-03-01

    This research is about gene distribution of ABO blood type system on the Dengue Hemorrhagic Fever (DHF) patients in the working area of Puskesmas Bonto Bangun, District of Rilau Ale, Bulukumba. This research aimed to determine the blood type which is most affected by DHF using ABO blood type system. In this research, there are 104 samples, 8 of them were attacked by DF and 96 were attacked by DHF. From the 96 patients of DHF, there were 38 patients with A-blood type, 17 patients with B-blood type, 36 patients with O-blood type and 5 patients of AB-blood type. The data were tested using genotype frequency test and the results showed that the percentage of A-homozygous blood type (IAIA) is 0:09%; A heterozygous blood type (IAIo) is 0:36%; B-homozygous blood type (IBIB) is 0.01%; B heterozygous blood type (IB Io) is 0.12%; AB blood type (IAIB) is 0.06% and O blood type (IoIo) is 12:36%. So the biggest frequency of genotype are IAIo (0.36%) and IoIo (0.36%). The results showed that O blood type gene is the most affected by DHF. Then continued by the regression test between blood type and DHF, it is obtained that the correlation value is 1 which indicated that there is a strong relationship.

  5. Quantification of patient specific assay interference in different formats of enzyme linked immunoassays for therapeutic monoclonal antibodies

    NARCIS (Netherlands)

    Grebenchtchikov, N.J.; Geurts-Moespot, A.; Heijmen, L.; Laarhoven, H.W.M. van; Herpen, C.M.L. van; Thijs, A.M.J.; Span, P.N.; Sweep, F.C.

    2014-01-01

    BackgroundThe use of therapeutic monoclonal antibodies for clinical purposes has significantly increased in recent years, and so has the need to monitor antibody concentrations. This may be achieved using the well-established enzyme linked immunoassay (ELISA) methods; however, these assays are

  6. Effectiveness evaluation of double-layered satellite network with laser and microwave hybrid links based on fuzzy analytic hierarchy process

    Science.gov (United States)

    Zhang, Wei; Rao, Qiaomeng

    2018-01-01

    In order to solve the problem of high speed, large capacity and limited spectrum resources of satellite communication network, a double-layered satellite network with global seamless coverage based on laser and microwave hybrid links is proposed in this paper. By analyzing the characteristics of the double-layered satellite network with laser and microwave hybrid links, an effectiveness evaluation index system for the network is established. And then, the fuzzy analytic hierarchy process, which combines the analytic hierarchy process and the fuzzy comprehensive evaluation theory, is used to evaluate the effectiveness of the double-layered satellite network with laser and microwave hybrid links. Furthermore, the evaluation result of the proposed hybrid link network is obtained by simulation. The effectiveness evaluation process of the proposed double-layered satellite network with laser and microwave hybrid links can help to optimize the design of hybrid link double-layered satellite network and improve the operating efficiency of the satellite system.

  7. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine : Linking cognition, brain activity, and psychosis

    NARCIS (Netherlands)

    Corlett, Philip R.; Honey, Garry D.; Aitken, Michael R. F.; Dickinson, Anthony; Shanks, David R.; Absalom, Anthony R.; Lee, Michael; Pomarol-Clotet, Edith; Murray, Graham K.; McKenna, Peter J.; Robbins, Trevor W.; Bullmore, Edward T.; Fletcher, Paul C.

    Context: Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis. Objective: To explore a theoretical model of delusion formation that implicates prediction error - dependent

  8. Tuvan-Mongolian relations and links under the People’s Republic of Tuva

    Directory of Open Access Journals (Sweden)

    Lubov K. Hertek

    2016-09-01

    Full Text Available The article examines the links and relations between Tuva and Mongolia during the two decades of People’s Republic of Tuva (1921-1944. Although some aspects of these relations have been studied by a number of Russian, Mongolian and Chinese scholars, they have so far failed to outline their general tendencies. In this article, we aim to study the Tuvan-Mongolian relations in the PRT period in the light of new archival materials, which will help us trace the main stages of their development and characterize the specific features of each stage. The first stage (1921-1925 opens with the establishment of Tuvan statehood and its non-recognition by Mongolia. Tuvan lamas and noyons retained their links to the highest-profile Mongolian clergy and the rulers of Mongolian aimags in the borderlands. The second stage (1926–1929 begins with the changes in leadership of both states, which led to PRT being officially recognized by the Mongolian People’s Republic. The recognition was followed by signing a Treaty of Friendship between the two states and the restoration of cultural links, given that traditional culture and the Mongolian written language still prevailed in Tuva. We have reconstructed a full list of Tuvan diplomatic envoys in Mongolia and Mongolian envoys in Tuva. The third stage (1930–1944 was marked by the victory of the political left in both Tuva and Mongolia. The new leaders of both states had been educated in Moscow, in Communist University of the Toilers of the East. This helped establish what was deemed ‘truly revolutionary mutual relations’ and build up an interparty network. Indirectly, it also helped enhance economic, trade and cultural links. Our study was based, among other sources, on archival documents from the State Archive of the Republic of Tuva, the research archive of Tuva Institute for Humanities and Applied Socioeconomic Studies, and some published sources from the Mongolian Ministry of Foreign Affairs’ archive

  9. A Novel Dedicated Route Protection Scheme for Survivability of Link Failure in Elastic Optical Networks

    Directory of Open Access Journals (Sweden)

    Sridhar Iyer

    2017-11-01

    Full Text Available The spectrally efficient transportation of the high bit rate(s data is achievable by the Elastic optical networks (EONs. However, in the EONs, owing to the failure occurrence even in an individual simple element, different service(s maybe interrupted. Hence, it is imperative that the schemes for survivability be developed so that the issues due to the possible failure(s can be overcome. In the current work, in view of survivability of the link failure(s in the EONs, we propose the Spectrum Continuity and Contiguity Established DRP (SCC-E-DRP algorithm which is a novel dedicated route protection (DRP scheme that attempts to avoid the problem of trap topology during its exploration for a pair of link disjoint path. Further, to evaluate the link disjoint paths, we resort to the use of the SCC Established Shortest Route (SCC-E-SR algorithm which is a modified Dijkstra’s algorithm based scheme that selects the path(s pair(s based on the end-toend SCC. We conduct extensive simulations considering realistic network topologies, and compare the performance of the SCCE-DRP scheme with the existing techniques. The obtained results show that, compared to the existing schemes, the SCC-E-DRP scheme achieves better results in terms of blocking probability.

  10. Making effective links to decision-making: Key challenges for health impact assessment

    International Nuclear Information System (INIS)

    Elliott, Eva; Francis, Sarah

    2005-01-01

    This paper draws on an exploratory research study to examine the effectiveness of health impact assessments in Wales. Through the review of five case study health impact assessments the research identified a number of benefits of the process in terms of skills and knowledge development amongst participants. The indirect contributions to decision-making were also evident including the way in which health impact assessment provided useful insights into the local community's perspective and raised awareness about the wider determinants of health. The process was also useful in establishing a dialogue between different stakeholders, which indirectly assisted decision-making and implementation. The direct links between health impact assessment and decision-making were more difficult to trace and this paper puts forward a number of suggestions for making those links more transparent. Suggestions include integrating decision-makers and clarifying the intended links to decision-making at the start of the health impact assessment process. Mainstreaming health impact assessment so that it is triggered as a routine part of all decision-making would help ensure it stands the best chance of informing decisions

  11. An algorithm for the diagnosis of X-linked intellectual disability in children

    Directory of Open Access Journals (Sweden)

    V. Yu. Voinova

    2016-01-01

    Full Text Available X-linked intellectual disability (XLID is a clinically and genetically heterogeneous group of hereditary diseases caused by mutations on the X chromosome, which lead to impaired intellectual development. The paper determines for the first time the proportion of X-linked diseases (6.54% in the pattern of intellectual disability in children. A system has been developed to quantify the clinical severity of fragile X mental retardation syndrome and Rett syndrome. A system has been scientifically justified to predict the clinical severity, which is based on an analysis of the impact of genetic and epigenetic factors (mutation type and location, X chromosome inactivation. The authors have determined the contribution of nonrandom X inactivation to the clinical polymorphism of various forms of XLID and established its role as an important diagnostic marker for pathology. It is shown that the study of X chromosome inactivation can identify asymptomatic female carriers of X-linked mutations to provide medical genetic counseling to families. An algorithm has been elaborated to diagnose XLID among the undifferentiated forms of mental developmental abnormalities in children. 

  12. Phosphorylation of human link proteins

    International Nuclear Information System (INIS)

    Oester, D.A.; Caterson, B.; Schwartz, E.R.

    1986-01-01

    Three link proteins of 48, 44 and 40 kDa were purified from human articular cartilage and identified with monoclonal anti-link protein antibody 8-A-4. Two sets of lower molecular weight proteins of 30-31 kDa and 24-26 kDa also contained link protein epitopes recognized by the monoclonal antibody and were most likely degradative products of the intact link proteins. The link proteins of 48 and 40 kDa were identified as phosphoproteins while the 44 kDa link protein did not contain 32 P. The phosphorylated 48 and 40 kDa link proteins contained approximately 2 moles PO 4 /mole link protein

  13. Effect of potential barrier growth of auto-localized excitons decay on radiation defects in AHC at low lattice symmetry

    International Nuclear Information System (INIS)

    Shunkeev, K.; Sagimbaeva, Sh.; Shunkeev, S.

    2007-01-01

    Effect of auto-localized excitons (ALE) luminescence strengthening is conditioned by two mechanisms: either decrease of potential barrier divided of quasi-free states and auto-localized states or decrease of emission-less channel effectiveness of exciton decay on primary radiation defects. In considered range (80 K) all excitons are only in auto-localized state. Therefore a realization of the first mechanism is improbable, For instant, in KI crystal at 80-100 K luminescence of free exciton is completely putting out, and ALE luminescence has maximal intensity. It is known that in the temperature range when ALE luminescence putting out is beginning an effectiveness of radiation defects is beginning to grow. This effect is related with predominating at that time emission-less exciton decay on radiation defects (F-H pairs). Experimentally by luminescence spectroscopy method activation energy of temperature putting out of ALE in AHC under uniaxial deformation. It is revealed, that increase of activation energy value has observed in a number of crystals: KBr→NaCl→KI→Na Br→CsBr→RbI. It is concluded, that effect of ALE intensity building-up and decrease of effectiveness of radiation defect formation are interpreted by growth of potential barrier of ALE decay into radiation defects under low symmetry of AHC lattice of low-temperature uniaxial deformation

  14. Inverse dynamic analysis of general n-link robot manipulators

    International Nuclear Information System (INIS)

    Yih, T.C.; Wang, T.Y.; Burks, B.L.; Babcock, S.M.

    1996-01-01

    In this paper, a generalized matrix approach is derived to analyze the dynamic forces and moments (torques) required by the joint actuators. This method is general enough to solve the problems of any n-link open-chain robot manipulators with joint combinations of R(revolute), P(prismatic), and S(spherical). On the other hand, the proposed matrix solution is applicable to both nonredundant and redundant robotic systems. The matrix notation is formulated based on the Newton-Euler equations under the condition of quasi-static equilibrium. The 4 x 4 homogeneous cylindrical coordinates-Bryant angles (C-B) notation is applied to model the robotic systems. Displacements, velocities, and accelerations of each joint and link center of gravity (CG) are calculated through kinematic analysis. The resultant external forces and moments exerted on the CG of each link are considered as known inputs. Subsequently, a 6n x 6n displacement coefficient matrix and a 6n x 1 external force/moment vector can be established. At last, the joint forces and moments needed for the joint actuators to control the robotic system are determined through matrix inversion. Numerical examples will be illustrated for the nonredundant industrial robots: Bendix AA/CNC (RRP/RRR) and Unimate 2000 spherical (SP/RRR) robots; and the redundant light duty utility arm (LDUA), modified LDUA, and tank waste retrieval manipulator system

  15. CD24 cross-linking induces apoptosis in, and inhibits migration of, MCF-7 breast cancer cells

    International Nuclear Information System (INIS)

    Kim, Jong Bin; Bae, Ji-Yeon; Jee, Hyeon-Gun; Noh, Dong-Young; Ko, Eunyoung; Han, Wonshik; Lee, Jeong Eon; Lee, Kyung-Min; Shin, Incheol; Kim, Sangmin; Lee, Jong Won; Cho, Jihyoung

    2008-01-01

    The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact of CD24 cross-linking on human breast cancer cell line MCF-7. MCF-7 and MDA-MB-231 cells were treated with anti-rabbit polyclonal IgG or anti-human CD24 rabbit polyclonal antibodies to induce cross-linking, and then growth was studied. Changes in cell characteristics such as cell cycle modulation, cell death, survival in three-dimensional cultures, adhesion, and migration ability were assayed after CD24 cross-linking in MCF-7. Expression of CD24 was analyzed by flow cytometry in MDA-MB-231 and MCF-7 cells where 2% and 66% expression frequencies were observed, respectively. CD24 cross-linking resulted in time-dependent proliferation reduction in MCF-7 cells, but no reduction in MDA-MB-231 cells. MCF-7 cell survival was reduced by 15% in three-dimensional culture after CD24 cross-linking. Increased MCF-7 cell apoptosis was observed after CD24 cross-linking, but no cell cycle arrest was observed in that condition. The migration capacity of MCF-7 cells was diminished by 30% after CD24 cross-linking. Our results showed that CD24 cross-linking induced apoptosis and inhibited migration in MCF-7 breast cancer cells. We conclude that CD24 may be considered as a novel therapeutic target for breast cancer

  16. What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents.

    Science.gov (United States)

    van Meer, Floor; van der Laan, Laura N; Adan, Roger A H; Viergever, Max A; Smeets, Paul A M

    2015-01-01

    Food cues are omnipresent and may enhance overconsumption. In the last two decades the prevalence of childhood obesity has increased dramatically all over the world, largely due to overconsumption. Understanding children's neural responses to food may help to develop better interventions for preventing or reducing overconsumption. We aimed to determine which brain regions are concurrently activated in children/adolescents in response to viewing food pictures, and how these relate to adult findings. Two activation likelihood estimation (ALE) meta-analyses were performed: one with studies in normal weight children/adolescents (aged 8-18, 8 studies, 137 foci) and one with studies in normal weight adults (aged 18-45, 16 studies, 178 foci). A contrast analysis was performed for children/adolescents vs. adults. In children/adolescents, the most concurrent clusters were in the left lateral orbitofrontal cortex (OFC), the bilateral fusiform gyrus, and the right superior parietal lobule. In adults, clusters in similar areas were found. Although the number of studies for a direct statistical comparison between the groups was relatively low, there were indications that children/adolescents may not activate areas important for cognitive control. Overall, the number of studies that contributed to the significant clusters was moderate (6-75%). In summary, the brain areas most consistently activated in children/adolescents by food viewing are part of the appetitive brain network and overlap with those found in adults. However, the age range of the children studied was rather broad. This study offers important recommendations for future research; studies making a direct comparison between adults and children in a sufficiently narrow age range would further elucidate how neural responses to food cues change during development. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. A first formal link between the price equation and an optimization program.

    Science.gov (United States)

    Grafen, Alan

    2002-07-07

    The Darwin unification project is pursued. A meta-model encompassing an important class of population genetic models is formed by adding an abstract model of the number of successful gametes to the Price equation under uncertainty. A class of optimization programs are defined to represent the "individual-as-maximizing-agent analogy" in a general way. It is then shown that for each population genetic model there is a corresponding optimization program with which formal links can be established. These links provide a secure logical foundation for the commonplace biological principle that natural selection leads organisms to act as if maximizing their "fitness", provides a definition of "fitness", and clarifies the limitations of that principle. The situations covered do not include frequency dependence or social behaviour, but the approach is capable of extension.

  18. Linking Data for Mothers and Babies in De-Identified Electronic Health Data.

    Directory of Open Access Journals (Sweden)

    Katie Harron

    Full Text Available Linkage of longitudinal administrative data for mothers and babies supports research and service evaluation in several populations around the world. We established a linked mother-baby cohort using pseudonymised, population-level data for England.Retrospective linkage study using electronic hospital records of mothers and babies admitted to NHS hospitals in England, captured in Hospital Episode Statistics between April 2001 and March 2013.Of 672,955 baby records in 2012/13, 280,470 (42% linked deterministically to a maternal record using hospital, GP practice, maternal age, birthweight, gestation, birth order and sex. A further 380,164 (56% records linked using probabilistic methods incorporating additional variables that could differ between mother/baby records (admission dates, ethnicity, 3/4-character postcode district or that include missing values (delivery variables. The false-match rate was estimated at 0.15% using synthetic data. Data quality improved over time: for 2001/02, 91% of baby records were linked (holding the estimated false-match rate at 0.15%. The linked cohort was representative of national distributions of gender, gestation, birth weight and maternal age, and captured approximately 97% of births in England.Probabilistic linkage of maternal and baby healthcare characteristics offers an efficient way to enrich maternity data, improve data quality, and create longitudinal cohorts for research and service evaluation. This approach could be extended to linkage of other datasets that have non-disclosive characteristics in common.

  19. Linking Data for Mothers and Babies in De-Identified Electronic Health Data

    Science.gov (United States)

    Gilbert, Ruth; Cromwell, David; van der Meulen, Jan

    2016-01-01

    Objective Linkage of longitudinal administrative data for mothers and babies supports research and service evaluation in several populations around the world. We established a linked mother-baby cohort using pseudonymised, population-level data for England. Design and Setting Retrospective linkage study using electronic hospital records of mothers and babies admitted to NHS hospitals in England, captured in Hospital Episode Statistics between April 2001 and March 2013. Results Of 672,955 baby records in 2012/13, 280,470 (42%) linked deterministically to a maternal record using hospital, GP practice, maternal age, birthweight, gestation, birth order and sex. A further 380,164 (56%) records linked using probabilistic methods incorporating additional variables that could differ between mother/baby records (admission dates, ethnicity, 3/4-character postcode district) or that include missing values (delivery variables). The false-match rate was estimated at 0.15% using synthetic data. Data quality improved over time: for 2001/02, 91% of baby records were linked (holding the estimated false-match rate at 0.15%). The linked cohort was representative of national distributions of gender, gestation, birth weight and maternal age, and captured approximately 97% of births in England. Conclusion Probabilistic linkage of maternal and baby healthcare characteristics offers an efficient way to enrich maternity data, improve data quality, and create longitudinal cohorts for research and service evaluation. This approach could be extended to linkage of other datasets that have non-disclosive characteristics in common. PMID:27764135

  20. a Task-Driven Disaster Data Link Approach

    Science.gov (United States)

    Qiu, L. Y.; Zhu, Q.; Gu, J. Y.; Du, Z. Q.

    2015-08-01

    With the rapid development of sensor networks and Earth observation technology, a large quantity of disaster-related data is available, such as remotely sensed data, historic data, cases data, simulation data, disaster products and so on. However, the efficiency of current data management and service systems has become increasingly serious due to the task variety and heterogeneous data. For emergency task-oriented applications, data searching mainly relies on artificial experience based on simple metadata index, whose high time-consuming and low accuracy cannot satisfy the requirements of disaster products on velocity and veracity. In this paper, a task-oriented linking method is proposed for efficient disaster data management and intelligent service, with the objectives of 1) putting forward ontologies of disaster task and data to unify the different semantics of multi-source information, 2) identifying the semantic mapping from emergency tasks to multiple sources on the basis of uniform description in 1), 3) linking task-related data automatically and calculating the degree of correlation between each data and a target task. The method breaks through traditional static management of disaster data and establishes a base for intelligent retrieval and active push of disaster information. The case study presented in this paper illustrates the use of the method with a flood emergency relief task.

  1. Quantification of patient-specific assay interference in different formats of enzyme-linked immunoassays for therapeutic monoclonal antibodies

    NARCIS (Netherlands)

    Grebenchtchikov, Nicolai; Geurts-Moespot, Anneke J.; Heijmen, Linda; van Laarhoven, Hanneke W. M.; van Herpen, Carla M. L.; Thijs, Annemarie M. J.; Span, Paul N.; Sweep, Fred C. G. J.

    2014-01-01

    The use of therapeutic monoclonal antibodies for clinical purposes has significantly increased in recent years, and so has the need to monitor antibody concentrations. This may be achieved using the well-established enzyme linked immunoassay (ELISA) methods; however, these assays are subject to a

  2. Factors Linking Childhood Experiences to Adult Romantic Relationships among African Americans

    OpenAIRE

    Simons, Leslie Gordon; Simons, Ronald L.; Landor, Antoinette M.; Bryant, Chalandra M.; Beach, Steven R.H.

    2014-01-01

    It is well known that a high quality relationship with a romantic partner is related to a variety of positive outcomes associated with health and well-being. Establishing such relationships is an important developmental task for young adults and past research indicates that there is a link between experiences in the family of origin and the success of later intimate relationships. It has been suggested that this association can be explained by the acquisition of social competencies (e.g., emo...

  3. Glutaraldehyde cross-linking of tendon mechanical effects at the level of the tendon fascicle and fibril

    DEFF Research Database (Denmark)

    Hansen, Philip; Hassenkam, Tue; Svensson, Rene Bruggebusch

    2009-01-01

    at the tendon fibril level were examined by atomic force microscopy. Peak forces increased from approximately 1379 to approximately 2622 pN while an extended Hertz fit of force-indentation data showed a approximately 24 fold increase in Young's modulus on indentation. The effect of glutaraldehyde cross......Conclusive insight into the microscopic principles that govern the strength of tendon and related connective tissues is lacking and the importance of collagen cross-linking has not been firmly established. The combined application of whole-tissue mechanical testing and atomic force spectroscopy...... allowed for a detailed characterization of the effect of cross-linking in rat-tail tendon. The cross-link inducing agent glutaraldehyde augmented the tensile strength of tendon fascicles. Stress at failure increased from approximately 8 MPa to approximately 39 MPa. The mechanical effects of glutaraldehyde...

  4. Señales físico químicas involucradas en la búsqueda de hospederos y en la inducción de picadura por mosquitos

    Directory of Open Access Journals (Sweden)

    Torres-Estrada José Luis

    2003-01-01

    Full Text Available Las hembras de los mosquitos vectores de enfermedades utilizan señales físicas y químicas para localizar su fuente de alimentación sanguínea en hospederos vertebrados. Los mosquitos zoofílicos responden preferentemente al CO2 y al octenol liberados en la respiración y excreciones, mientras que los mosquitos antropofílicos responden al ácido láctico y a una variedad de compuestos del sudor. Estos compuestos son modificados por microrganismos saprófitos de las glándulas sebáceas de la piel. Otros factores presentes en las viviendas contribuyen a la integración de microsistemas constituidos por olores característicos, que explican los diferentes niveles de atracción de mosquitos y la focalización de la transmisión del paludismo a una porción de casas en localidades de áreas endémicas. La identificación de estos atrayentes químicos y sus moléculas receptoras en mosquitos puede ser utilizada como complemento de nuevos métodos para la vigilancia epidemiológica, para atraer a los mosquitos a trampas de colecta o para incrementar su contacto con insecticidas usados en su control, así como en la manipulación genética para desviar las picaduras de los mosquitos hacia otros hospederos vertebrados.

  5. Carrier detection in X-linked retinitis pigmentosa by multipoint DNA analysis. Problems due to genetic heterogeneity

    NARCIS (Netherlands)

    Bergen, A. A.; Platje, E. J.; Craig, I.; Bakker, E.; Bleeker-Wagemakers, E. M.; van Ommen, G. J.

    1991-01-01

    DNA diagnosis of X-linked retinitis pigmentosa (XLRP) is hampered by its genetic heterogeneity, while a clinical subdivision is almost impossible to make. So far, diagnostic services have been offered only to those families in which linkage to one RP locus (RP2 or RP3) has been clearly established.

  6. Compassionate love as a mechanism linking sacred qualities of marriage to older couples' marital satisfaction.

    Science.gov (United States)

    Sabey, Allen K; Rauer, Amy J; Jensen, Jakob F

    2014-10-01

    Previous work has underscored the robust links between sanctification of marriage and marital outcomes, and recent developments in the literature suggest that compassionate love, which is important for intimate relationships, may act as a mediator of that relationship. Accordingly, the current study used actor-partner interdependence models to examine the relationship between a spiritual cognition (i.e., perceived sacred qualities of marriage) and marital satisfaction, and to determine whether that relationship is mediated by compassionate love, in a sample of older married couples (N = 64). Results revealed that wives' greater sacred qualities of marriage were significantly and positively linked to marital satisfaction on the part of both spouses, and that these links were partially mediated by couples' reports of compassionate love. These findings highlight the importance of moving beyond simply establishing the existence of the link between global markers of involvement of religion and marriage to understanding how specific spiritual cognitions may foster better relationship quality, especially among older couples. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  7. Past, Current, and Future Challenges in Linking Data to Publications

    Science.gov (United States)

    Hanson, B.

    2015-12-01

    Data are the currency of science and assure the integrity of published research. As the ability to collect, analyze, and visualize data has grown beyond what could be included in a publication, and as the value of the data become more clear (or the lack of availability of data was criticized), publishers and the scientific community developed several solutions to enhance access to underlying data. Most leading journals now require authors to agree as a condition of submission that underlying data will be included or made available; indeed, publication is the key leverage point in exposing much scholarly data. Most journals allow PDF or other supplements and links to data sets hosted by authors or labs, or better, data repositories such as Dryad, and some have banned "data not shown" or any reference to unpublished work. Many of these solutions have proven problematic and recent studies have found that large fraction of data are undiscoverable even a few years after publication. The best solution has been dedicated domain repositories collectively supported by publishers, funders, and the scientific community and where deposition is required before or at the time of publication. These provide quality control and curation and facilitate reuse. However, expanding these beyond a few key repositories and developing standardized workflows and functionality among repositories and between them and publishers has been problematic. Addressing these and other data challenges requires collaborative efforts among funders, publishers, repositories, societies, and researchers. One example is the Coalition on Publishing Data in the the Earth and space sciences, where most major publishers and repositories have signed a joint statement of commitment (COPDESS.org), and are starting work to direct and link published data to domain repositories. Much work remains to be done. Major challenges include establishing data curation practices into the workflow of science from data collection

  8. TULIP: A Link-Level Protocol for Improving TCP over Wireless Links

    National Research Council Canada - National Science Library

    Parsa, Christina; Garcia-Luna-Aceves, J. J

    1999-01-01

    We present the transport unaware link improvement protocol (TULIP), which dramatically improves the performance of TCP over lossy wireless links, without competing with or modifying the transport- or network-layer protocols...

  9. Dynamic link: user's manual

    International Nuclear Information System (INIS)

    Harada, Hiroo; Asai, Kiyoshi; Kihara, Kazuhisa.

    1981-09-01

    The purpose of dynamic link facility is to link a load module dynamically only when it is used in execution time. The facility is very useful for development, execution and maintenance of a large scale computer program which is too big to be saved as one load module in main memory, or it is poor economy to save it due to many unused subroutines depending on an input. It is also useful for standardization and common utilization of programs. Standard usage of dynamic link facility of FACOM M-200 computer system, a software tool which analyzes the effect of dynamic link facility and application of dynamic link to nuclear codes are described. (author)

  10. An Adaptive Laboratory Evolution Method to Accelerate Autotrophic Metabolism

    DEFF Research Database (Denmark)

    Zhang, Tian; Tremblay, Pier-Luc

    2018-01-01

    Adaptive laboratory evolution (ALE) is an approach enabling the development of novel characteristics in microbial strains via the application of a constant selection pressure. This method is also an efficient tool to acquire insights on molecular mechanisms responsible for specific phenotypes. ALE...... autotrophically and reducing CO2 into acetate more efficiently. Strains developed via this ALE method were also used to gain knowledge on the autotrophic metabolism of S. ovata as well as other acetogenic bacteria....

  11. establishing a link between adult education and community ...

    African Journals Online (AJOL)

    COMMUNITY DEVELOPMENT FOR IMPROVED TEACHING,. LEARNING AND ... ABSTRACT. Adult education and community development are two areas of practices which development ... life of the people and national development. .... balanced and independent social, ... communal work. .... and maintain cooperative.

  12. Antiallergic Activity of Ethanol Extracts of Arctium lappa L. Undried Roots and Its Active Compound, Oleamide, in Regulating FcεRI-Mediated and MAPK Signaling in RBL-2H3 Cells.

    Science.gov (United States)

    Yang, Woong-Suk; Lee, Sung Ryul; Jeong, Yong Joon; Park, Dae Won; Cho, Young Mi; Joo, Hae Mi; Kim, Inhye; Seu, Young-Bae; Sohn, Eun-Hwa; Kang, Se Chan

    2016-05-11

    The antiallergic potential of Arctium lappa L. was investigated in Sprague-Dawley rats, ICR mice, and RBL-2H3 cells. Ethanol extract (90%) of A. lappa (ALE, 100 μg/mL) inhibited the degranulation rate by 52.9%, determined by the level of β-hexosaminidase. ALE suppressed passive cutaneous anaphylaxis (PCA) in rats and attenuated anaphylaxis and histamine release in mice. To identify the active compound of ALE, we subsequently fractionated and determined the level of β-hexosaminidase in all subfractions. Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-α and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA). Oleamide suppressed FcεRI-tyrosine kinase Lyn-mediated pathway, c-Jun N-terminal kinases (JNK/SAPK), and p38 mitogen-activated protein kinases (p38-MAPKs). These results showed that ALE and oleamide attenuated allergic reactions and should serve as a platform to search for compounds with antiallergic activity.

  13. 71-Mbit/s ultraviolet-B LED communication link based on 8-QAM-OFDM modulation.

    Science.gov (United States)

    Sun, Xiaobin; Zhang, Zhenyu; Chaaban, Anas; Ng, Tien Khee; Shen, Chao; Chen, Rui; Yan, Jianchang; Sun, Haiding; Li, Xiaohang; Wang, Junxi; Li, Jinmin; Alouini, Mohamed-Slim; Ooi, Boon S

    2017-09-18

    A demonstration of ultraviolet-B (UVB) communication link is implemented utilizing quadrature amplitude modulation (QAM) orthogonal frequency-division multiplexing (OFDM). The demonstration is based on a 294-nm UVB-light-emitting-diode (UVB-LED) with a full-width at half-maximum (FWHM) of 9 nm and light output power of 190 μW, at 7 V, with a special silica gel lens on top of it. A -3-dB bandwidth of 29 MHz was measured and a high-speed near-solar-blind communication link with a data rate of 71 Mbit/s was achieved using 8-QAM-OFDM at perfect alignment. 23.6 Mbit/s using 2-QAM-OFDM when the angle subtended by the pointing directions of the UVB-LED and photodetector (PD) is 12 degrees, thus establishing a diffuse-line-of-sight (LOS) link. The measured bit-error rate (BER) of 2.8 ×10 -4 and 2.4 ×10 -4 , respectively, are well below the forward error correction (FEC) criterion of 3.8 ×10 -3 . The demonstrated high data-rate OFDM-based UVB communication link paves the way for realizing high-speed non-line-of-sight free-space optical communications.

  14. Property Values Associated with the Failure of Individual Links in a System with Multiple Weak and Strong Links.

    Energy Technology Data Exchange (ETDEWEB)

    Helton, Jon C. [Arizona State Univ., Tempe, AZ (United States); Brooks, Dusty Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sallaberry, Cedric Jean-Marie. [Engineering Mechanics Corp. of Columbus, OH (United States)

    2018-02-01

    Representations are developed and illustrated for the distribution of link property values at the time of link failure in the presence of aleatory uncertainty in link properties. The following topics are considered: (i) defining properties for weak links and strong links, (ii) cumulative distribution functions (CDFs) for link failure time, (iii) integral-based derivation of CDFs for link property at time of link failure, (iv) sampling-based approximation of CDFs for link property at time of link failure, (v) verification of integral-based and sampling-based determinations of CDFs for link property at time of link failure, (vi) distributions of link properties conditional on time of link failure, and (vii) equivalence of two different integral-based derivations of CDFs for link property at time of link failure.

  15. A comprehensive comparison of network similarities for link prediction and spurious link elimination

    Science.gov (United States)

    Zhang, Peng; Qiu, Dan; Zeng, An; Xiao, Jinghua

    2018-06-01

    Identifying missing interactions in complex networks, known as link prediction, is realized by estimating the likelihood of the existence of a link between two nodes according to the observed links and nodes' attributes. Similar approaches have also been employed to identify and remove spurious links in networks which is crucial for improving the reliability of network data. In network science, the likelihood for two nodes having a connection strongly depends on their structural similarity. The key to address these two problems thus becomes how to objectively measure the similarity between nodes in networks. In the literature, numerous network similarity metrics have been proposed and their accuracy has been discussed independently in previous works. In this paper, we systematically compare the accuracy of 18 similarity metrics in both link prediction and spurious link elimination when the observed networks are very sparse or consist of inaccurate linking information. Interestingly, some methods have high prediction accuracy, they tend to perform low accuracy in identification spurious interaction. We further find that methods can be classified into several cluster according to their behaviors. This work is useful for guiding future use of these similarity metrics for different purposes.

  16. Atomic Layer Etching of Silicon to Solve ARDE-Selectivity-Profile-Uniformity Trade-Offs

    Science.gov (United States)

    Wang, Mingmei; Ranjan, Alok; Ventzek, Peter; Koshiishi, Akira

    2014-10-01

    With shrinking critical dimensions, dry etch faces more and more challenges. Minimizing each of aspect ratio dependent etching (ARDE), bowing, undercut, selectivity, and within die uniformly across a wafer are met by trading off one requirement against another. At the root of the problem is that roles radical flux, ion flux and ion energy play may be both good and bad. Increasing one parameter helps meeting one requirement but hinders meeting the other. Self-limiting processes like atomic layer etching (ALE) promise a way to escape the problem of balancing trade-offs. ALE was realized in the mid-1990s but the industrial implementation has been slow. In recent years interest in ALE has revived. We present how ARDE, bowing/selectivity trade-offs may be overcome by varying radical/ion ratio, byproduct re-deposition. We overcome many of the practical implementation issues associated with ALE by precise passivation process control. The Monte Carlo Feature Profile Model (MCFPM) is used to illustrate realistic scenarios built around an Ar/Cl2 chemistry driven etch of Si masked by SiO2. We demonstrate that ALE can achieve zero ARDE and infinite selectivity. Profile control depends on careful management of the ion energies and angles. For ALE to be realized in production environment, tight control of IAD is a necessary. Experimental results are compared with simulation results to provide context to the work.

  17. Clasificador de Imágenes del Diagnóstico Thomson Scattering del TJ II Basado en Template Matching

    Directory of Open Access Journals (Sweden)

    Jesús A. Vega Sánchez

    2010-07-01

    Full Text Available La automatización del análisis de las señales generadas en un ambiente de fusión nuclear constituye una meta importante. El presente trabajo se encuadra en el contexto del desarrollo de clasificadores automáticos para las señales generadas en el Diagnóstico Thomson Scattering del TJ II, siendo este un ambiente de fusión específico. Dos etapas fundamentales son consideradas en el diseño del clasificador: el procesamiento de las señales y extracción de sus características, por un lado, y la clasificación, por otro. La primera es implementada, en el trabajo, recurriendo a las transformadas wavelet mientras que la segunda es implementada a través de la comparación entre las características de las señales disponibles y las de un conjunto de señales previamente seleccionadas como prototipos (template matching, operación esta que es efectuada utilizando a técnicas de trayectoria de búsqueda óptimas basadas en programación dinámica. En el mismo se muestra que la metodología empleada permite la clasificación de las señales en cuestión y que con un entrenamiento adecuado se puede extraer un buen rendimiento al clasificador desarrollado.

  18. Design and Analysis of Underwater Acoustic Networks with Reflected Links

    Science.gov (United States)

    Emokpae, Lloyd

    Underwater acoustic networks (UWANs) have applications in environmental state monitoring, oceanic profile measurements, leak detection in oil fields, distributed surveillance, and navigation. For these applications, sets of nodes are employed to collaboratively monitor an area of interest and track certain events or phenomena. In addition, it is common to find autonomous underwater vehicles (AUVs) acting as mobile sensor nodes that perform search-and-rescue missions, reconnaissance in combat zones, and coastal patrol. These AUVs are to work cooperatively to achieve a desired goal and thus need to be able to, in an ad-hoc manner, establish and sustain communication links in order to ensure some desired level of quality of service. Therefore, each node is required to adapt to environmental changes and be able to overcome broken communication links caused by external noise affecting the communication channel due to node mobility. In addition, since radio waves are quickly absorbed in the water medium, it is common for most underwater applications to rely on acoustic (or sound) rather than radio channels for mid-to-long range communications. However, acoustic channels pose multiple challenging issues, most notably the high transmission delay due to slow signal propagation and the limited channel bandwidth due to high frequency attenuation. Moreover, the inhomogeneous property of the water medium affects the sound speed profile while the signal surface and bottom reflections leads to multipath effects. In this dissertation, we address these networking challenges by developing protocols that take into consideration the underwater physical layer dynamics. We begin by introducing a novel surface-based reflection scheme (SBR), which takes advantage of the multipath effects of the acoustic channel. SBR works by using reflections from the water surface, and bottom, to establish non-line-of-sight (NLOS) communication links. SBR makes it possible to incorporate both line

  19. Website Policies / Important Links | DOepatents

    Science.gov (United States)

    Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and first) Publication Date (oldest first) Close Clear All Find DOepatents Website Policies / Important Important Links Some links on this page may take you to non-federal websites. Their policies may differ from

  20. Linking neuroethology to the chemical biology of natural products

    DEFF Research Database (Denmark)

    Olivera, Baldomero M.; Raghuraman, Shrinivasan; Schmidt, Eric W.

    2017-01-01

    From a biological perspective, a natural product can be defined as a compound evolved by an organism for chemical interactions with another organism including prey, predator, competitor, pathogen, symbiont or host. Natural products hold tremendous potential as drug leads and have been extensively...... a better understanding of the evolution, biology and biochemistry of natural products will facilitate both neuroscience and the potential for drug leads. The larger goal is to establish a new sub-discipline in the broader field of neuroethology that we refer to as “Chemical Neuroethology”, linking...... the substantial work carried out by chemists on natural products with accelerating advances in neuroethology....

  1. The SAIL databank: linking multiple health and social care datasets.

    Science.gov (United States)

    Lyons, Ronan A; Jones, Kerina H; John, Gareth; Brooks, Caroline J; Verplancke, Jean-Philippe; Ford, David V; Brown, Ginevra; Leake, Ken

    2009-01-16

    Vast amounts of data are collected about patients and service users in the course of health and social care service delivery. Electronic data systems for patient records have the potential to revolutionise service delivery and research. But in order to achieve this, it is essential that the ability to link the data at the individual record level be retained whilst adhering to the principles of information governance. The SAIL (Secure Anonymised Information Linkage) databank has been established using disparate datasets, and over 500 million records from multiple health and social care service providers have been loaded to date, with further growth in progress. Having established the infrastructure of the databank, the aim of this work was to develop and implement an accurate matching process to enable the assignment of a unique Anonymous Linking Field (ALF) to person-based records to make the databank ready for record-linkage research studies. An SQL-based matching algorithm (MACRAL, Matching Algorithm for Consistent Results in Anonymised Linkage) was developed for this purpose. Firstly the suitability of using a valid NHS number as the basis of a unique identifier was assessed using MACRAL. Secondly, MACRAL was applied in turn to match primary care, secondary care and social services datasets to the NHS Administrative Register (NHSAR), to assess the efficacy of this process, and the optimum matching technique. The validation of using the NHS number yielded specificity values > 99.8% and sensitivity values > 94.6% using probabilistic record linkage (PRL) at the 50% threshold, and error rates were SAIL databank represents a research-ready platform for record-linkage studies.

  2. Improving local clustering based top-L link prediction methods via asymmetric link clustering information

    Science.gov (United States)

    Wu, Zhihao; Lin, Youfang; Zhao, Yiji; Yan, Hongyan

    2018-02-01

    Networks can represent a wide range of complex systems, such as social, biological and technological systems. Link prediction is one of the most important problems in network analysis, and has attracted much research interest recently. Many link prediction methods have been proposed to solve this problem with various techniques. We can note that clustering information plays an important role in solving the link prediction problem. In previous literatures, we find node clustering coefficient appears frequently in many link prediction methods. However, node clustering coefficient is limited to describe the role of a common-neighbor in different local networks, because it cannot distinguish different clustering abilities of a node to different node pairs. In this paper, we shift our focus from nodes to links, and propose the concept of asymmetric link clustering (ALC) coefficient. Further, we improve three node clustering based link prediction methods via the concept of ALC. The experimental results demonstrate that ALC-based methods outperform node clustering based methods, especially achieving remarkable improvements on food web, hamster friendship and Internet networks. Besides, comparing with other methods, the performance of ALC-based methods are very stable in both globalized and personalized top-L link prediction tasks.

  3. Evolution of Escherichia coli to 42 °C and Subsequent Genetic Engineering Reveals Adaptive Mechanisms and Novel Mutations

    DEFF Research Database (Denmark)

    Sandberg, Troy E.; Pedersen, Margit; LaCroix, Ryan A.

    2014-01-01

    Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to investigate microbial adaptation to a desired environment. Here, we performed ALE to 42 °C of ten parallel populations of Escherichia coli K-12 MG1655 grown in glucose minimal media. Tightly controlled experimental c...... targets for additional ameliorating mutations. Overall, the results of this study provide insight into the adaptation process and yield lessons important for the future implementation of ALE as a tool for scientific research and engineering....

  4. WO3 and W Thermal Atomic Layer Etching Using "Conversion-Fluorination" and "Oxidation-Conversion-Fluorination" Mechanisms.

    Science.gov (United States)

    Johnson, Nicholas R; George, Steven M

    2017-10-04

    The thermal atomic layer etching (ALE) of WO 3 and W was demonstrated with new "conversion-fluorination" and "oxidation-conversion-fluorination" etching mechanisms. Both of these mechanisms are based on sequential, self-limiting reactions. WO 3 ALE was achieved by a "conversion-fluorination" mechanism using an AB exposure sequence with boron trichloride (BCl 3 ) and hydrogen fluoride (HF). BCl 3 converts the WO 3 surface to a B 2 O 3 layer while forming volatile WO x Cl y products. Subsequently, HF spontaneously etches the B 2 O 3 layer producing volatile BF 3 and H 2 O products. In situ spectroscopic ellipsometry (SE) studies determined that the BCl 3 and HF reactions were self-limiting versus exposure. The WO 3 ALE etch rates increased with temperature from 0.55 Å/cycle at 128 °C to 4.19 Å/cycle at 207 °C. W served as an etch stop because BCl 3 and HF could not etch the underlying W film. W ALE was performed using a three-step "oxidation-conversion-fluorination" mechanism. In this ABC exposure sequence, the W surface is first oxidized to a WO 3 layer using O 2 /O 3 . Subsequently, the WO 3 layer is etched with BCl 3 and HF. SE could simultaneously monitor the W and WO 3 thicknesses and conversion of W to WO 3 . SE measurements showed that the W film thickness decreased linearly with number of ABC reaction cycles. W ALE was shown to be self-limiting with respect to each reaction in the ABC process. The etch rate for W ALE was ∼2.5 Å/cycle at 207 °C. An oxide thickness of ∼20 Å remained after W ALE, but could be removed by sequential BCl 3 and HF exposures without affecting the W layer. These new etching mechanisms will enable the thermal ALE of a variety of additional metal materials including those that have volatile metal fluorides.

  5. Afinitatea şi unele particularităţi fiziologice ale diferitor rase de lupoaie (Orobanche cumana wallr.

    Directory of Open Access Journals (Sweden)

    Maria DUCA

    2016-12-01

    Full Text Available The interaction between sunflower (host and broomrape (parasite is directly influenced by physiological and biochemical characteristics of the pathogen, characterized by affinity, virulence and aggressiveness. The parasitization process of broomrape begins with the germination of seeds and is induced by germination stimulants located in the rhizosphere of sunflower plants. In this study the germination capacity of broomrape seeds (45 populations collected from sunflower and tobacco agrocenosis has been evaluated on exudates obtained from the root system of various sunflower genotypes: the sensitive genotype LMD1 and differential lines resistant to races E, F, G and H. Broomrape seeds from tobacco agrocenosis germinated on all studied exudates, showing a high level of affinity to host plant. Therefore, the germination inductors specific to sunflower induced the germination process of the parasite characteristic for the anthophytoses on tobacco plants. The average germination rate on the root exudate of the sensible genotype LMD1 was 15,2% and on the exudate of the race H differential (HLG 5661 - 17,7%. Indicators significantly lower were noted in the other variants under study. Rezumat. Interacţiunea dintre floarea-soarelui (gazdă şi lupoaie (parazit este direct influenţată de particularităţile fiziologice şi biochimice ale patogenului, caracterizate prin afinitate, virulenţă, agresivitate. Procesul de parazitare a lupoaiei începe cu germinarea seminţelor, indusă de stimulenţi de germinare prezenţi în rizosfera plantelor de floarea soarelui. În acest studiu a fost evaluată capacitatea de germinare a seminţelor de lupoaie (45 de populaţii colectate din agrocenoze de floarea-soarelui şi tutun pe exudate obţinute din sistemul radicular al diferitor genotipuri de floarea-soarelui: genotipul sensibil LMD1 şi linii diferenţiatoare cu rezistenţa cunoscută la rasele de lupoaie E,F, G şi H. Lupoaia din agrocenozele de tutun a

  6. Gamete donors' reasons for, and expectations and experiences of, registration with a voluntary donor linking register.

    Science.gov (United States)

    Blyth, Eric; Crawshaw, Marilyn; Frith, Lucy; van den Akker, Olga

    2017-12-01

    This paper reports on a study of the views and experiences of 21 sperm donors and five egg donors registered with UK DonorLink (UKDL), a voluntary DNA-based contact register established to facilitate contact between adults who wish to identify and locate others to whom they are genetically related following donor conception. Specifically, the paper examines donors' reasons for searching for, or making information about themselves available to donor-conceived offspring. Their expectations of registration with UKDL, experiences of being registered and finally, the experiences of those who had contacted donor-conceived offspring and other genetic relatives are investigated. While most respondents reported largely positive experiences of registration, the study found significant issues relating to concerns about donation, DNA testing, possible linking with offspring and expectations of any relationship that might be established with offspring that have implications for support, mediation and counselling. Research that puts the experiences, perceptions and interests of gamete donors as the central focus of study is a relatively recent phenomenon. This study contributes to this debate and highlights directions for future research in this area.

  7. DC-Link Compensation Method for Slim DC Link Drives Fed by Soft Grid

    DEFF Research Database (Denmark)

    Mathe, Laszlo; Rosendahl Andersen, Henrik; Lazar, Radu

    2010-01-01

    Slim DC-link PWM (AC) drives for lowperformance applications are emerging on the market. Such drives equipped with a small DC-link capacitance exhibit instability tendencies, if installed on a soft line, giving a degraded performance. The total harmonic distortion (THD) and the partially weighted...... harmonic distortion (PWHD) of the line current are degraded, if resonance between the line impedance and the DC-link capacitance occurs. Likewise, the motor performance is affected negatively giving extra torque ripple, vibration and acoustic-noise emission. This paper proposes a novel DC-link compensation...

  8. Links among impossible differential, integral and zero correlation linear cryptanalysis

    DEFF Research Database (Denmark)

    Sun, Bing; Liu, Zhiqiang; Rijmen, Vincent

    2015-01-01

    is to fix this gap and establish links between impossible differential cryptanalysis and integral cryptanalysis. Firstly, by introducing the concept of structure and dual structure, we prove that a → b is an impossible differential of a structure E if and only if it is a zero correlation linear hull...... linear hull always indicates the existence of an integral distinguisher. With this observation we improve the number of rounds of integral distinguishers of Feistel structures, CAST-256, SMS4 and Camellia. Finally, we conclude that an r-round impossible differential of E always leads to an r...

  9. Data linkage in an established longitudinal cohort: the Western Australian Pregnancy Cohort (Raine) Study.

    Science.gov (United States)

    Mountain, Jenny A; Nyaradi, Anett; Oddy, Wendy H; Glauert, Rebecca A; de Klerk, Nick H; Straker, Leon M; Stanley, Fiona J

    2016-07-15

    The Western Australian Data Linkage System is one of a few comprehensive, population-based data linkage systems worldwide, creating links between information from different sources relating to the same individual, family, place or event, while maintaining privacy. The Raine Study is an established cohort study with more than 2000 currently active participants. Individual consent was obtained from participants for information in publicly held databases to be linked to their study data. A waiver of consent was granted where it was impracticable to obtain consent. Approvals to link the datasets were obtained from relevant ethics committees and data custodians. The Raine Study dataset was subsequently linked to academic testing data collected by the Western Australian Department of Education. Examination of diet and academic performance showed that children who were predominantly breastfed for at least 6 months scored higher academically at age 10 than children who were breastfed for less than 6 months. A further study found that better diet quality at ages 1, 2 and 3 years was associated with higher academic scores at ages 10 and 12 years. Examination of nutritional intake at 14 years of age found that a better dietary pattern was associated with higher academic performance. The detailed longitudinal data collected in the Raine Study allowed for adjustment for multiple covariates and confounders. Data linkage reduces the burden on cohort participants by providing additional information without the need to contact participants. It can give information on participants who have been lost to follow-up; provide or complement missing data; give the opportunity for validation studies comparing recall of participants with administrative records; increase the population sample of studies by adding control participants from the general population; and allow for the adjustment of multiple covariates and confounders. The Raine Study dataset is extensive and detailed, and can be

  10. Supervised Agricultural Experience Programmes (SAEP) and Work Linked Education (WLE): Panacea for Empowering Youths and Preventing Joblessness

    Science.gov (United States)

    Famiwole, Remigius O.

    2015-01-01

    Youths from Nigerian schools and tertiary institutions are usually unemployable after schooling because they are not empowered with the required saleable skills to earn them a job or with which to establish as entrepreneurs. This paper examines the relevance of Supervised Agricultural Experience Programme (SAEP) and Work Linked Education (WLE) as…

  11. Linked Data Reactor: a Framework for Building Reactive Linked Data Applications

    NARCIS (Netherlands)

    Khalili, Ali

    2016-01-01

    This paper presents Linked Data Reactor (LD-Reactor or LD-R) as a framework for developing exible and reusable User Interface components for Linked Data applications. LD-Reactor utilizes Facebook's ReactJS components, Flux architecture and Yahoo's Fluxible framework for isomorphic Web applications.

  12. The philosophical and pedagogical underpinnings of Active Learning in Engineering Education

    Science.gov (United States)

    Christie, Michael; de Graaff, Erik

    2017-01-01

    In this paper the authors draw on three sequential keynote addresses that they gave at Active Learning in Engineering Education (ALE) workshops in Copenhagen (2012), Caxias do Sol (2014) and San Sebastian (2015). Active Learning in Engineering Education is an informal international network of engineering educators dedicated to improving engineering education through active learning (http://www.ale-net.org/). The paper reiterates themes from those keynotes, namely, the philosophical and pedagogical underpinnings of Active Learning in Engineering Education, the scholarly questions that inspire engineering educators to go on improving their practice and exemplary models designed to activate the learning of engineering students. This paper aims to uncover the bedrock of established educational philosophies and theories that define and support active learning. The paper does not claim to present any new or innovative educational theory. There is already a surfeit of them. Rather, the aim is to assist Engineering Educators who wish to research how they can best activate the learning of their students by providing a readable, reasonable and solid underpinning for best practice in this field.

  13. EarthCube GeoLink: Semantics and Linked Data for the Geosciences

    Science.gov (United States)

    Arko, R. A.; Carbotte, S. M.; Chandler, C. L.; Cheatham, M.; Fils, D.; Hitzler, P.; Janowicz, K.; Ji, P.; Jones, M. B.; Krisnadhi, A.; Lehnert, K. A.; Mickle, A.; Narock, T.; O'Brien, M.; Raymond, L. M.; Schildhauer, M.; Shepherd, A.; Wiebe, P. H.

    2015-12-01

    The NSF EarthCube initiative is building next-generation cyberinfrastructure to aid geoscientists in collecting, accessing, analyzing, sharing, and visualizing their data and knowledge. The EarthCube GeoLink Building Block project focuses on a specific set of software protocols and vocabularies, often characterized as the Semantic Web and "Linked Data", to publish data online in a way that is easily discoverable, accessible, and interoperable. GeoLink brings together specialists from the computer science, geoscience, and library science domains, and includes data from a network of NSF-funded repositories that support scientific studies in marine geology, marine ecosystems, biogeochemistry, and paleoclimatology. We are working collaboratively with closely-related Building Block projects including EarthCollab and CINERGI, and solicit feedback from RCN projects including Cyberinfrastructure for Paleogeosciences (C4P) and iSamples. GeoLink has developed a modular ontology that describes essential geoscience research concepts; published data from seven collections (to date) on the Web as geospatially-enabled Linked Data using this ontology; matched and mapped data between collections using shared identifiers for investigators, repositories, datasets, funding awards, platforms, research cruises, physical specimens, and gazetteer features; and aggregated the results in a shared knowledgebase that can be queried via a standard SPARQL endpoint. Client applications have been built around the knowledgebase, including a Web/map-based data browser using the Leaflet JavaScript library and a simple query service using the OpenSearch format. Future development will include extending and refining the GeoLink ontology, adding content from additional repositories, developing semi-automated algorithms to enhance metadata, and further work on client applications.

  14. Linked Health Data: how linked data can help provide better health decisions.

    Science.gov (United States)

    Farinelli, Fernanda; Barcellos de Almeida, Maurício; Linhares de Souza, Yóris

    2015-01-01

    This paper provides a brief survey about the use of linked data in healthcare to foster better health decisions and increase health knowledge. We present real cases from the Brazilian experience and emphasize some issues in research. This paper is not intending to be fully comprehensive, we discuss some open issues and research challenges in linked data and the technologies involved. We conclude that even though linked data has been adopted in many countries, some challenges have to be overcome, for example, interoperability between different standards. A defined solution able to foster the semantic interoperability between different standards must be developed. Benefits contributed through linked health data involve better decision making on diagnostics, assertive treatments, knowledge acquisition, improvements in quality healthcare service to citizens.

  15. LinkMind: link optimization in swarming mobile sensor networks.

    Science.gov (United States)

    Ngo, Trung Dung

    2011-01-01

    A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation.

  16. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    Directory of Open Access Journals (Sweden)

    Trung Dung Ngo

    2011-08-01

    Full Text Available A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation.

  17. Active Learning in Engineering Education: a (re)introduction

    DEFF Research Database (Denmark)

    Lima, Rui M.; Andersson, Pernille Hammar; Saalman, Elisabeth

    2017-01-01

    The informal network ‘Active Learning in Engineering Education’ (ALE) has been promoting Active Learning since 2001. ALE creates opportunity for practitioners and researchers of engineering education to collaboratively learn how to foster learning of engineering students. The activities in ALE...... were reviewed by the European Journal of Engineering Education community and this theme issue ended up with eight contributions, which are different both in their research and Active Learning approaches. These different Active Learning approaches are aligned with the different approaches that can...

  18. On the groundstate energy spectrum of magnetic knots and links

    International Nuclear Information System (INIS)

    Ricca, Renzo L; Maggioni, Francesca

    2014-01-01

    By using analytical results for the constrained minimum energy of magnetic knots we determine the influence of internal twist on the minimum magnetic energy levels of knots and links, and by using ropelength data from the RIDGERUNNER tightening algorithm (Ashton et al 2011 Exp. Math. 20 57–90) we obtain the groundstate energy spectra of the first 250 prime knots and 130 prime links. The two spectra are found to follow an almost identical logarithmic law. By assuming that the number of knot types grows exponentially with the topological crossing number, we show that this generic behavior can be justified by a general relationship between ropelength and crossing number, which is in good agreement with former analytical estimates (Buck and Simon 1999 Topol. Appl. 91 245–57, Diao 2003 J. Knot Theory Ramifications 12 1–16). Moreover, by considering the ropelength averaged over a given knot family, we establish a new connection between the averaged ropelength and the topological crossing number of magnetic knots. (paper)

  19. INFORMATION TECHNOLOGY AND ROMANIAN HIGHER EDUCATION - EVIDENCE ON LINKED DYNAMIC

    Directory of Open Access Journals (Sweden)

    Bogdan Nichifor

    2014-07-01

    Full Text Available The link between education, in general, and information technologies is one that does not necessarily have to be demonstrated. But it is interesting to see the specific link that is established between these two components of modern society. In recent years, part-time education forms tend to occupy an increasingly important position in the Romanian higher education from the perspective of the total number of students opting for distance learning or traditional part-time learning. This development occurred amid expansion of information technology - more and more households have Internet access and frequency of its use is increasing from year to year – in the context in which forms of part – time learning require the use of this means of information and communication. On this background more and more people over 25 years become interested in further developing their studies, including employed persons opting for further studies, increasing the share of students over 25 years in total students and the share of employed population over 25 years with higher education in total in respective age group.

  20. A New Remote Communications Link to Reduce Residential PV Solar Costs

    Energy Technology Data Exchange (ETDEWEB)

    King, Randy [Operant Solar Corporation,CA (United States); Sugiyama, Rod [Operant Solar Corporation,CA (United States)

    2017-12-11

    Monitoring of PV/DER site production is expensive to install and unreliable. Among third party systems providers, lost communications links are a growing concern. Nearly 20% of links are failing, provisioning is complex, recovery is expensive, production data is lost, and access is fragmented. FleetLink is a new concept in DER system communications, purpose built for lowering the cost of maintaining active contact with residential end user sites and ensuring that production data is reliably available to third party systems providers. Systems providers require accurate, secure system monitoring and reporting of production data and system faults while driving down overall costs to compete effectively. This plug and play, independently operating communications solution lowers the cost of fleet contact from typically .08 dollars-$.12/W down to .02 dollars -.03/W including installation and maintenance expenses. FleetLink establishes a breakthrough in simplicity that facilitates rapid expansion of residential solar by reducing initial capital outlay and lowering installation labor time and skill levels. The solution also facilitates higher DER installation growth rates by driving down maintenance costs and eliminating communications trouble calls. This is accomplished by the FleetLink’s unique network technology that enables dynamic network configuration for fast changes, and active, self-healing DER site contact for uptime assurance. Using an open source network framework with proprietary, application specific enhancements, FleetLink independently manages connectivity, security, recovery, grid control communications, and fleet expansion while presenting a compliant SunSpec interface to the third party operations centers. The net system cost savings of at least .05 dollars/W supports the SunShot cost goals and the flexibility and scalability of the solution accelerates the velocity and ubiquitous adoption of solar.

  1. Age differences in search of web pages: the effects of link size, link number, and clutter.

    Science.gov (United States)

    Grahame, Michael; Laberge, Jason; Scialfa, Charles T

    2004-01-01

    Reaction time, eye movements, and errors were measured during visual search of Web pages to determine age-related differences in performance as a function of link size, link number, link location, and clutter. Participants (15 young adults, M = 23 years; 14 older adults, M = 57 years) searched Web pages for target links that varied from trial to trial. During one half of the trials, links were enlarged from 10-point to 12-point font. Target location was distributed among the left, center, and bottom portions of the screen. Clutter was manipulated according to the percentage of used space, including graphics and text, and the number of potentially distracting nontarget links was varied. Increased link size improved performance, whereas increased clutter and links hampered search, especially for older adults. Results also showed that links located in the left region of the page were found most easily. Actual or potential applications of this research include Web site design to increase usability, particularly for older adults.

  2. Establishment, maintenance, and re-establishment of the safe and efficient steady-following state

    International Nuclear Information System (INIS)

    Pan Deng; Zheng Ying-Ping

    2015-01-01

    We present an integrated mathematical model of vehicle-following control for the establishment, maintenance, and re-establishment of the previous or new safe and efficient steady-following state. The hyperbolic functions are introduced to establish the corresponding mathematical models, which can describe the behavioral adjustment of the following vehicle steered by a well-experienced driver under complex vehicle following situations. According to the proposed mathematical models, the control laws of the following vehicle adjusting its own behavior can be calculated for its moving in safety, efficiency, and smoothness (comfort). Simulation results show that the safe and efficient steady-following state can be well established, maintained, and re-established by its own smooth (comfortable) behavioral adjustment with the synchronous control of the following vehicle’s velocity, acceleration, and the actual following distance. (paper)

  3. Operative Links

    DEFF Research Database (Denmark)

    Wistoft, Karen; Højlund, Holger

    2012-01-01

    and have been the object of great expectations concerning the ability to incorporate health concerns into every welfare area through health promotion strategies. The paper draws on results and analyses of a collective research project funded by the Danish National Research Council and carried out...... links' that indicate cooperative levels which facilitate a creative and innovative effort in disease prevention and health promotion targeted at children and adolescents - across traditional professional boundaries. It is proposed that such links are supported by network structures, shared semantics...

  4. Link prediction with node clustering coefficient

    Science.gov (United States)

    Wu, Zhihao; Lin, Youfang; Wang, Jing; Gregory, Steve

    2016-06-01

    Predicting missing links in incomplete complex networks efficiently and accurately is still a challenging problem. The recently proposed Cannistrai-Alanis-Ravai (CAR) index shows the power of local link/triangle information in improving link-prediction accuracy. Inspired by the idea of employing local link/triangle information, we propose a new similarity index with more local structure information. In our method, local link/triangle structure information can be conveyed by clustering coefficient of common-neighbors directly. The reason why clustering coefficient has good effectiveness in estimating the contribution of a common-neighbor is that it employs links existing between neighbors of a common-neighbor and these links have the same structural position with the candidate link to this common-neighbor. In our experiments, three estimators: precision, AUP and AUC are used to evaluate the accuracy of link prediction algorithms. Experimental results on ten tested networks drawn from various fields show that our new index is more effective in predicting missing links than CAR index, especially for networks with low correlation between number of common-neighbors and number of links between common-neighbors.

  5. Improving Care And Research Electronic Data Trust Antwerp (iCAREdata): a research database of linked data on out-of-hours primary care.

    Science.gov (United States)

    Colliers, Annelies; Bartholomeeusen, Stefaan; Remmen, Roy; Coenen, Samuel; Michiels, Barbara; Bastiaens, Hilde; Van Royen, Paul; Verhoeven, Veronique; Holmgren, Philip; De Ruyck, Bernard; Philips, Hilde

    2016-05-04

    Primary out-of-hours care is developing throughout Europe. High-quality databases with linked data from primary health services can help to improve research and future health services. In 2014, a central clinical research database infrastructure was established (iCAREdata: Improving Care And Research Electronic Data Trust Antwerp, www.icaredata.eu ) for primary and interdisciplinary health care at the University of Antwerp, linking data from General Practice Cooperatives, Emergency Departments and Pharmacies during out-of-hours care. Medical data are pseudonymised using the services of a Trusted Third Party, which encodes private information about patients and physicians before data is sent to iCAREdata. iCAREdata provides many new research opportunities in the fields of clinical epidemiology, health care management and quality of care. A key aspect will be to ensure the quality of data registration by all health care providers. This article describes the establishment of a research database and the possibilities of linking data from different primary out-of-hours care providers, with the potential to help to improve research and the quality of health care services.

  6. The Role of Plant-Parasitic Nematodes and Soil-Borne Fungi in the Decline of Ammophila-Arenaria (L) Link

    NARCIS (Netherlands)

    De Rooij van der Goes, P.C.E.M.

    1995-01-01

    In coastal foredunes, Ammophila arenaria (L.) Link grows vigorously when it is buried regularly by windblown sand and degenerates at stabilized sites. Nematodes and soil-borne fungi were found to be involved in its decline. In order to establish their role in the disease complex, seedlings of A.

  7. The Bridge: Linking Mood Induction, Self-Report, and Psychophysiology to Vocabulary Learning on a Paired-Associates Learning Task

    Science.gov (United States)

    Fox, Jessica Kate

    2017-01-01

    Researchers in the field of second language acquisition continue to establish links between cognition and emotion (Dewaele, 2013; MacIntyre, 2002; MacIntyre & Gardner, 1989, 1991b, 1994; Segalowitz & Trofimovich, 2011). The purpose of the present study is to investigate to what extent physiological and self-report measures predict…

  8. Dynamic analysis of maritime gasbag-type floating bridge subjected to moving loads

    OpenAIRE

    Huan-huan Wang; Xian-long Jin

    2016-01-01

    This paper studied the dynamic response of a new gasbag-type floating bridge under the effect of a moving load. The arbitrary Lagrangian-Eulerian (ALE) method was used to simulate the movement of seawater and air, and the penalty-based method was used to study the coupling between gasbags and fluid. A three-dimensional finite element model of the floating bridge was established, and the numerical model was verified by comparing with the experimental results. In order to prevent resonance, the...

  9. New three-phase ac-ac converter incorporating three-phase boost integrated ZVT bridge and single-phase HF link

    International Nuclear Information System (INIS)

    Abdelhamid, Tamer H.; Sabzali, Ahmad J.

    2008-01-01

    This paper presents a new zero voltage transition (ZVT), power factor corrected three phase ac-ac converter with single phase high frequency (HF) link. It is a two stage converter; the first stage is a boost integrated bridge converter (combination of a 3 ph boost converter and a bridge converter) operated at fixed frequency and that operates in two modes at ZVT for all switches and establishes a 1 ph square wave HF link. The second stage is a bi-directional pulse width modulation (PWM) 3 ph bridge that converts the 1 ph HF link to a 3 ph voltage using a novel switching strategy. The converter modes of operation and key equations are outlined. Simulation of the overall system is conducted using Simulink. The switching strategy and its corresponding control circuit are clearly described. Experimental verification of the simulation is conducted for a prototype of 100 V, 500 W at 10 kHz link frequency

  10. Energy Link Optimization in a Wireless Power Transfer Grid under Energy Autonomy Based on the Improved Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Zhihao Zhao

    2016-08-01

    Full Text Available In this paper, an optimization method is proposed for the energy link in a wireless power transfer grid, which is a regional smart microgrid comprised of distributed devices equipped with wireless power transfer technology in a certain area. The relevant optimization model of the energy link is established by considering the wireless power transfer characteristics and the grid characteristics brought in by the device repeaters. Then, a concentration adaptive genetic algorithm (CAGA is proposed to optimize the energy link. The algorithm avoided the unification trend by introducing the concentration mechanism and a new crossover method named forward order crossover, as well as the adaptive parameter mechanism, which are utilized together to keep the diversity of the optimization solution groups. The results show that CAGA is feasible and competitive for the energy link optimization in different situations. This proposed algorithm performs better than its counterparts in the global convergence ability and the algorithm robustness.

  11. Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, Cheryl [Michigan State University, East Lansing; Nisbet, Roger [University of California Santa Barbara; Antczak, Philipp [University of Liverpool, UK; Reyero, Natalia [Army Corps of Engineers, Vicksburg; Gergs, Andre [Gaiac; Lika, Dina [University of Crete; Mathews, Teresa J. [ORNL; Muller, Eric [University of California, Santa Barbara; Nacci, Dianne [U.S. Environmental Protection Agency (EPA); Peace, Angela L. [ORNL; Remien, Chris [University of Idaho; Schulz, Irv [Pacific Northwest National Laboratory (PNNL); Watanabe, Karen [Arizona State University

    2018-02-01

    Ecological risk assessment quantifies the likelihood of undesirable impacts of stressors, primarily at high levels of biological organization. Data used to inform ecological risk assessments come primarily from tests on individual organisms or from suborganismal studies, indicating a disconnect between primary data and protection goals. We know how to relate individual responses to population dynamics using individual-based models, and there are emerging ideas on how to make connections to ecosystem services. However, there is no established methodology to connect effects seen at higher levels of biological organization with suborganismal dynamics, despite progress made in identifying Adverse Outcome Pathways (AOPs) that link molecular initiating events to ecologically relevant key events. This chapter is a product of a working group at the National Center for Mathematical and Biological Synthesis (NIMBioS) that assessed the feasibility of using dynamic energy budget (DEB) models of individual organisms as a “pivot” connecting suborganismal processes to higher level ecological processes. AOP models quantify explicit molecular, cellular or organ-level processes, but do not offer a route to linking sub-organismal damage to adverse effects on individual growth, reproduction, and survival, which can be propagated to the population level through individual-based models. DEB models describe these processes, but use abstract variables with undetermined connections to suborganismal biology. We propose linking DEB and quantitative AOP models by interpreting AOP key events as measures of damage-inducing processes in a DEB model. Here, we present a conceptual model for linking AOPs to DEB models and review existing modeling tools available for both AOP and DEB.

  12. Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model.

    Science.gov (United States)

    Chakraborty, Tridib; Bhuniya, Dipak; Chatterjee, Mary; Rahaman, Mosiur; Singha, Dipak; Chatterjee, Baidya Nath; Datta, Subrata; Rana, Ajay; Samanta, Kartick; Srivastawa, Sunil; Maitra, Sankar K; Chatterjee, Malay

    2007-12-28

    To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma (EAC)-bearing murine model. Male Swiss albino mice were divided into four groups: Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal (ip) inoculations of rapidly proliferating 2 x 10(5) viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract (ALE) of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation (ALE control); and Group D was the EAC + ALE-treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein (MT) protein, sister-chromatid exchanges (SCEs), and DNA alterations. Treatment of the EAC-bearing mice with the ALE significantly (P decrement (P single-strand breaks (SSBs) by 38.53% (3.14 +/- 0.31 vs 1.93 +/- 0.23, P < 0.01) in EAC-bearing murine liver. Our data indicate that, ALE is beneficial in restoring haematological and hepatic histological profiles and in lengthening the survival of the animals against the proliferation of ascites tumour in vivo. Finally, the chemopreventive efficacy of the ALE is manifested in limiting MT expression and in preventing DNA alterations in murine liver. The promising results of this study suggest further investigation into the chemopreventive mechanisms of the medicinal plant A. ilicifolius in vivo and in vitro.

  13. Use of Adaptive Laboratory Evolution To Discover Key Mutations Enabling Rapid Growth of Escherichia coli K-12 MG1655 on Glucose Minimal Medium

    DEFF Research Database (Denmark)

    LaCroix, Ryan A.; Sandberg, Troy E.; O'Brien, Edward J.

    2015-01-01

    Adaptive laboratory evolution (ALE) has emerged as an effective tool for scientific discovery and addressing biotechnological needs. Much of ALE's utility is derived from reproducibly obtained fitness increases. Identifying causal genetic changes and their combinatorial effects is challenging...

  14. 71-Mbit/s ultraviolet-B LED communication link based on 8-QAM-OFDM modulation

    KAUST Repository

    Sun, Xiaobin

    2017-09-14

    A demonstration of ultraviolet-B (UVB) communication link is implemented utilizing quadrature amplitude modulation (QAM) orthogonal frequency-division multiplexing (OFDM). The demonstration is based on a 294-nm UVB-light-emitting-diode (UVB-LED) with a full-width at half-maximum (FWHM) of 9 nm and light output power of 190 μW, at 7 V, with a special silica gel lens on top of it. A −3-dB bandwidth of 29 MHz was measured and a high-speed near-solar-blind communication link with a data rate of 71 Mbit/s was achieved using 8-QAM-OFDM at perfect alignment. 23.6 Mbit/s using 2-QAM-OFDM when the angle subtended by the pointing directions of the UVB-LED and photodetector (PD) is 12 degrees, thus establishing a diffuse-line-of-sight (LOS) link. The measured bit-error rate (BER) of 2.8 × 10−4 and 2.4 × 10−4, respectively, are well below the forward error correction (FEC) criterion of 3.8 × 10−3. The demonstrated high data-rate OFDM-based UVB communication link paves the way for realizing high-speed non-line-of-sight free-space optical communications.

  15. 71-Mbit/s ultraviolet-B LED communication link based on 8-QAM-OFDM modulation

    KAUST Repository

    Sun, Xiaobin; Zhang, Zhenyu; Chaaban, Anas; Ng, Tien Khee; Shen, Chao; Chen, Rui; Yan, Jianchang; Sun, Haiding; Li, Xiaohang; Wang, Junxi; Li, Jinmin; Alouini, Mohamed-Slim; Ooi, Boon S.

    2017-01-01

    A demonstration of ultraviolet-B (UVB) communication link is implemented utilizing quadrature amplitude modulation (QAM) orthogonal frequency-division multiplexing (OFDM). The demonstration is based on a 294-nm UVB-light-emitting-diode (UVB-LED) with a full-width at half-maximum (FWHM) of 9 nm and light output power of 190 μW, at 7 V, with a special silica gel lens on top of it. A −3-dB bandwidth of 29 MHz was measured and a high-speed near-solar-blind communication link with a data rate of 71 Mbit/s was achieved using 8-QAM-OFDM at perfect alignment. 23.6 Mbit/s using 2-QAM-OFDM when the angle subtended by the pointing directions of the UVB-LED and photodetector (PD) is 12 degrees, thus establishing a diffuse-line-of-sight (LOS) link. The measured bit-error rate (BER) of 2.8 × 10−4 and 2.4 × 10−4, respectively, are well below the forward error correction (FEC) criterion of 3.8 × 10−3. The demonstrated high data-rate OFDM-based UVB communication link paves the way for realizing high-speed non-line-of-sight free-space optical communications.

  16. GENERAL ASSESMENT OF SEED STANDS OF ORIENTAL SPRUCE (Picea orientalis L. Link.

    Directory of Open Access Journals (Sweden)

    İbrahim Turna

    2001-04-01

    Full Text Available The seeds for afforestation studies with oriental spruce (Picea orientalis L.Link. populations are usually gathered from already established seed stands. This study showed that most of the seed stands were not selected appropriately and some of them were not properly protected and maintained when evaluated according to the “criteria for selection and management of seed stands”. The average slope of seed stands was as high as 43% and the average size varied from 33.5 ha to 147.5 ha Since the stands were open to social disturbances and wind effects, the number of trees per ha decreased 51% and the number of seed trees dropped to a level of 56%. In conclusion, seeds collected from poorly established seed stands will likely jeopardize the success in reforestation studies in the future.

  17. The Independence Pipeline project : ANR's supply link - Independence Pipeline, Transco's market link

    International Nuclear Information System (INIS)

    Persells, T.

    1998-01-01

    An overview of the Independence Pipeline project was presented. The project offers access from Chicago to the U.S. Midwest market, as well as to Ontario via MichCon, Consumers Power, Great Lakes and Panhandle. The project has three components: ANR's Supply Link, the Independence Pipeline and Transco's MarketLink. The three components are budgeted at $ 1.332 billion dollars and projected for completion between Nov 1999 and Nov 2000. Each component (services, access advantages, market links, rates, storage services, etc ) are described separately. figs

  18. Corneal cross-linking in a child with osteogenesis imperfecta syndrome and keratoconus

    Directory of Open Access Journals (Sweden)

    Sergio Kwitko

    2017-07-01

    Full Text Available Cross-linking (CXL is a well-established procedure in children with keratoconus (KC, but cases of CXL and osteogenesis imperfecta (OI have not been published in the literature, despite the association between physiopathology of these diseases. This is the first case, to the best of our knowledge, of a young girl with both OI and KC that underwent a CXL treatment. In this case, CXL was performed at 6-years-old prior to an expected progression, without complications and probably stopped further keratoconus progression.

  19. A link between inflammation and metastasis

    DEFF Research Database (Denmark)

    Hansen, M. T.; Forst, B.; Cremers, N.

    2015-01-01

    S100A4 is implicated in metastasis and chronic inflammation, but its function remains uncertain. Here we establish an S100A4-dependent link between inflammation and metastatic tumor progression. We found that the acute-phase response proteins serum amyloid A (SAA) 1 and SAA3 are transcriptional...... targets of S100A4 via Toll-like receptor 4 (TLR4)/nuclear factor-κB signaling. SAA proteins stimulated the transcription of RANTES (regulated upon activation normal T-cell expressed and presumably secreted), G-CSF (granulocyte-colony-stimulating factor) and MMP2 (matrix metalloproteinase 2), MMP3, MMP9...... and MMP13. We have also shown for the first time that SAA stimulate their own transcription as well as that of proinflammatory S100A8 and S100A9 proteins. Moreover, they strongly enhanced tumor cell adhesion to fibronectin, and stimulated migration and invasion of human and mouse tumor cells...

  20. Control de la mano robot Inmoov-SR mediante casco NeuroSky Mindset

    OpenAIRE

    Hernández Martínez, Antonio

    2017-01-01

    En este trabajo el objetivo es conseguir controlar los movimientos de apertura y cierre de la mano robot InMoov-SR conectada al brazo IRB120 de ABB mediante señales EEG, recogidas por medio del casco NeuroSky Mindset. Las señales son recogidas cuando el sujeto está en estado basal y cuando realiza movimiento con su mano y son procesadas con la ayuda de Matlab para de esta manera conseguir establecer las señales de control necesarias para activar la apertura o el cierre de la mano. Final...

  1. Entropic benefit of a cross-link in protein association.

    Science.gov (United States)

    Zaman, Muhammad H; Berry, R Stephen; Sosnick, Tobin R

    2002-08-01

    We introduce a method to estimate the loss of configurational entropy upon insertion of a cross-link to a dimeric system. First, a clear distinction is established between the loss of entropy upon tethering and binding, two quantities that are often considered to be equivalent. By comparing the probability distribution of the center-to-center distances for untethered and cross-linked versions, we are able to calculate the loss of translational entropy upon cross-linking. The distribution function for the untethered helices is calculated from the probability that a given helix is closer to its partner than to all other helices, the "Nearest Neighbor" method. This method requires no assumptions about the nature of the solvent, and hence resolves difficulties normally associated with calculations for systems in liquids. Analysis of the restriction of angular freedom upon tethering indicates that the loss of rotational entropy is negligible. The method is applied in the context of the folding of a ten turn helical coiled coil with the tether modeled as a Gaussian chain or a flexible amino acid chain. After correcting for loop closure entropy in the docked state, we estimate the introduction of a six-residue tether in the coiled coil results in an effective concentration of the chain to be about 4 or 100 mM, depending upon whether the helices are denatured or pre-folded prior to their association. Thus, tethering results in significant stabilization for systems with millimolar or stronger dissociation constants. Copyright 2002 Wiley-Liss, Inc.

  2. Experience and Its Generation

    Institute of Scientific and Technical Information of China (English)

    Chen Youqing

    2006-01-01

    Experience iS an activity that arouses emotions and generates meanings based on vivid sensation and profound compreh ension.It iS emotional,meaningful,and personal,playing a key role in the course of forming and developing one'S qualities.The psychological process of experience generation consists of such links as sensing things,arousing emotions,promoting comprehension and association,generating insights and meanings,and deepening emotional responses.Undergoing things personally by means of direct sensation,taking part in activities,and living life are the most important preconditions of experience generation.Emotional influence,situational edification,and arts edification ale extemal factors that induce experience generation.

  3. Utilization of the series resonant dc link converter as a conditioning system for SMES

    International Nuclear Information System (INIS)

    Marschke, K.W.; Caldeira, P.P.A.; Lipo, T.A.

    1992-01-01

    In this paper a new superconductive magnetic energy storage (SMES) system utilizes a high-frequency series resonant dc link power converter of high efficiency as the conditioning converter is presented. This system generates a high-frequency (20 kHz or more) resonant current in a series link and switching is done at zero current instants, reducing switching losses to a minimal value. Through the utilization of an adequate control strategy, the input power factor can be fully adjusted during the charging, storing, and discharging modes of the SMES, improving the overall system efficiency. Different semiconductor devices are employed as the switching elements of the resonant converter and switching losses are established for each case. Experimental results from a monophase and three-phase system verified the results obtained from digital simulation

  4. Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness

    DEFF Research Database (Denmark)

    Davidson, Alice E; Cheong, Sek-Shir; Hysi, Pirro G

    2014-01-01

    We describe novel CHRDL1 mutations in ten families with X-linked megalocornea (MGC1). Our mutation-positive cohort enabled us to establish ultrasonography as a reliable clinical diagnostic tool to distinguish between MGC1 and primary congenital glaucoma (PCG). Megalocornea is also a feature of Ne...

  5. Seismic link at plate boundary

    Indian Academy of Sciences (India)

    time series to determine the causality and related orientation. The resulting link ... Triggering causes changes in the Coulomb stress on a specified fault, which is ... work link shows that the alignment of the links is parallel to the Honshu Trench ...

  6. Hacking 360 Link: A hybrid approach

    Directory of Open Access Journals (Sweden)

    John Durno

    2012-10-01

    Full Text Available When the University of Victoria Libraries switched from a locally-hosted link resolver (SFX to a vendor-hosted link resolver (360Link, new strategies were required to effectively integrate the vendor-hosted link resolver with the Libraries' other systems and services. Custom javascript is used to add links to the 360Link page; these links then point at local PHP code running on UVic servers, which can then redirect to appropriate local service or display a form directly. An open source PHP OpenURL parser class is announced. Consideration is given to the importance of maintaining open protocols and standards in the transition to vendor-hosted services.

  7. Establishment and characterization of a hypocatalasemic mouse cell strain

    International Nuclear Information System (INIS)

    Utsumi, Hiroshi; Tano, Keizo; Hashimoto, Mitsumasa W.; Kodama, Seiji; Watanabe, Hiromitsu

    1998-01-01

    Contact-inhibited catalase-deficient fibroblast cell strain has been established from the homozygous hypocatalasemic C3H/Cs b mutant mouse. This cell strain has low level of catalase enzyme activity and has normal level of enzyme activities of both glutathione peroxidase and superoxide dismutase. Catalase-deficient C3H/Cs b mutant cell strain is markedly more sensitive to the toxicity of hydrogen peroxide compared to wild-type C3H/Cs a cell strain. In addition, mutant cell strain is sensitive to X-rays and near-UV compared to wild-type cell strain, but shows the same sensitivities to topoisomerase II inhibitors, adriamycin and 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA), and the DNA cross-linking agents, cis-diamminedichloroplatinum (II) (cis-Pt) and trans-diamminedichloroplatinum (II) (trans-Pt). These cell strains will be of use in the study of the roles which catalase plays in the intracellular prevention of DNA damage induced by oxidative stress. (author)

  8. Radiation cross-linked collagen/dextran dermal scaffolds: effects of dextran on cross-linking and degradation.

    Science.gov (United States)

    Zhang, Yaqing; Zhang, Xiangmei; Xu, Ling; Wei, Shicheng; Zhai, Maolin

    2015-01-01

    Ionizing radiation effectively cross-links collagen into network with enhanced anti-degradability and biocompatibility, while radiation-cross-linked collagen scaffold lacks flexibility, satisfactory surface appearance, and performs poor in cell penetration and ingrowth. To make the radiation-cross-linked collagen scaffold to serve as an ideal artificial dermis, dextran was incorporated into collagen. Scaffolds with the collagen/dextran (Col/Dex) ratios of 10/0, 7/3, and 5/5 were fabricated via (60)Co γ-irradiation cross-linking, followed by lyophilization. The morphology, microstructure, physicochemical, and biological properties were investigated. Compared with pure collagen, scaffolds with dextran demonstrated more porous appearance, enhanced hydrophilicity while the cross-linking density was lower with the consequence of larger pore size, higher water uptake, as well as reduced stiffness. Accelerated degradation was observed when dextran was incorporated in both the in vitro and in vivo assays, which led to earlier integration with cell and host tissue. The effect of dextran on degradation was ascribed to the decreased cross-linking density, looser microstructure, more porous and hydrophilic surface. Considering the better appearance, softness, moderate degradation rate due to controllable cross-linking degree and good biocompatibility as well, radiation-cross-linked collagen/dextran scaffolds are expected to serve as promising artificial dermal substitutes.

  9. Extreme value problems without calculus: a good link with geometry and elementary maths

    Science.gov (United States)

    Ganci, Salvatore

    2016-11-01

    Some classical examples of problem solving, where an extreme value condition is required, are here considered and/or revisited. The search for non-calculus solutions appears pedagogically useful and intriguing as shown through a rich literature. A teacher, who teaches both maths and physics, (as happens in Italian High schools) can find in these kinds of problems a mind stimulating exercise compared with the standard solution obtained by the differential calculus. A good link between the geometric and analytical explanations is so established.

  10. High-resolution 3D laser imaging based on tunable fiber array link

    Science.gov (United States)

    Zhao, Sisi; Ruan, Ningjuan; Yang, Song

    2017-10-01

    Airborne photoelectric reconnaissance system with the bore sight down to the ground is an important battlefield situational awareness system, which can be used for reconnaissance and surveillance of complex ground scene. Airborne 3D imaging Lidar system is recognized as the most potential candidates for target detection under the complex background, and is progressing in the directions of high resolution, long distance detection, high sensitivity, low power consumption, high reliability, eye safe and multi-functional. However, the traditional 3D laser imaging system has the disadvantages of lower imaging resolutions because of the small size of the existing detector, and large volume. This paper proposes a high resolution laser 3D imaging technology based on the tunable optical fiber array link. The echo signal is modulated by a tunable optical fiber array link and then transmitted to the focal plane detector. The detector converts the optical signal into electrical signals which is given to the computer. Then, the computer accomplishes the signal calculation and image restoration based on modulation information, and then reconstructs the target image. This paper establishes the mathematical model of tunable optical fiber array signal receiving link, and proposes the simulation and analysis of the affect factors on high density multidimensional point cloud reconstruction.

  11. Cascade of links in complex networks

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Yeqian; Sun, Bihui [Department of Management Science, School of Government, Beijing Normal University, 100875 Beijing (China); Zeng, An, E-mail: anzeng@bnu.edu.cn [School of Systems Science, Beijing Normal University, 100875 Beijing (China)

    2017-01-30

    Cascading failure is an important process which has been widely used to model catastrophic events such as blackouts and financial crisis in real systems. However, so far most of the studies in the literature focus on the cascading process on nodes, leaving the possibility of link cascade overlooked. In many real cases, the catastrophic events are actually formed by the successive disappearance of links. Examples exist in the financial systems where the firms and banks (i.e. nodes) still exist but many financial trades (i.e. links) are gone during the crisis, and the air transportation systems where the airports (i.e. nodes) are still functional but many airlines (i.e. links) stop operating during bad weather. In this letter, we develop a link cascade model in complex networks. With this model, we find that both artificial and real networks tend to collapse even if a few links are initially attacked. However, the link cascading process can be effectively terminated by setting a few strong nodes in the network which do not respond to any link reduction. Finally, a simulated annealing algorithm is used to optimize the location of these strong nodes, which significantly improves the robustness of the networks against the link cascade. - Highlights: • We propose a link cascade model in complex networks. • Both artificial and real networks tend to collapse even if a few links are initially attacked. • The link cascading process can be effectively terminated by setting a few strong nodes. • A simulated annealing algorithm is used to optimize the location of these strong nodes.

  12. Cascade of links in complex networks

    International Nuclear Information System (INIS)

    Feng, Yeqian; Sun, Bihui; Zeng, An

    2017-01-01

    Cascading failure is an important process which has been widely used to model catastrophic events such as blackouts and financial crisis in real systems. However, so far most of the studies in the literature focus on the cascading process on nodes, leaving the possibility of link cascade overlooked. In many real cases, the catastrophic events are actually formed by the successive disappearance of links. Examples exist in the financial systems where the firms and banks (i.e. nodes) still exist but many financial trades (i.e. links) are gone during the crisis, and the air transportation systems where the airports (i.e. nodes) are still functional but many airlines (i.e. links) stop operating during bad weather. In this letter, we develop a link cascade model in complex networks. With this model, we find that both artificial and real networks tend to collapse even if a few links are initially attacked. However, the link cascading process can be effectively terminated by setting a few strong nodes in the network which do not respond to any link reduction. Finally, a simulated annealing algorithm is used to optimize the location of these strong nodes, which significantly improves the robustness of the networks against the link cascade. - Highlights: • We propose a link cascade model in complex networks. • Both artificial and real networks tend to collapse even if a few links are initially attacked. • The link cascading process can be effectively terminated by setting a few strong nodes. • A simulated annealing algorithm is used to optimize the location of these strong nodes.

  13. Cross-linking of polymeric materials

    International Nuclear Information System (INIS)

    Bloom, L.I.; Du Plessis, T.A.; Meij, G.O.

    1991-01-01

    The invention provides a method of producing a cured polymeric artifact from a polymeric thermoplastic starting material, the material of the artifact having reduced thermoplasticity relative to the starting material and exhibiting an enhanced degree of cross-linking relative to the starting material. The method includes subjecting a polymeric thermoplastic starting material, which is capable of being cross-linked by irradiation, to sufficient irradiation partially to cross-linked the starting material to produce a thermoplastic partially cross-linked intermediate material. The thermoplasticity of the intermediate material is then reduced by heating it to raise its melting point. The invention also provides a method of making a partially cross-linked feedstocks and a master batch for use in making such artifacts

  14. Linking social capital, cultural capital and heterotopia at the folk festival

    Directory of Open Access Journals (Sweden)

    Linda Wilks

    2016-06-01

    Full Text Available This paper investigates the role of folk festivals in transforming interconnections between people, space and culture. It interlinks three sets of theoretical ideas: social capital, cultural capital and heterotopia to suggest a new conceptual framework that will help to frame a deeper understanding of the nature of celebration. Qualitative data were collected at two long-established folk festivals, Sidmouth Folk Festival in southern England and the Feakle Traditional Music Festival in western Ireland, in order to investigate these potential links. Although Foucault did not fully develop the concept of heterotopia, his explanation that heterotopias are counter-sites, which, unlike utopias, are located in real, physical, space-time, has inspired others, including some festival researchers, to build on his ideas. This study concludes that the heterotopian concept of the festival as sacred space, with the stage as umbilicus, may be linked to the building of social capital; while it is suggested that both social capital and appropriate cultural capital are needed to gain full entry to the heterotopia.

  15. The Intensity of Human Body Odors and the MHC: Should We Expect a Link?

    OpenAIRE

    Claus Wedekind; Thomas Seebeck; Florence Bettens; Alexander J. Paepke

    2006-01-01

    It is now well established that genes within the major histocompatibility complex (MHC) somehow affect the production of body odors in several vertebrates, including humans. Here we discuss whether variation in the intensity of body odors may be influenced by the MHC. In order to examine this question, we have to control for MHC-linked odor perception on the smeller's side. Such a control is necessary because the perception of pleasantness and intensity seem to be confounded, a...

  16. Possible configuration of two-knot auto-localized exciton in strainless and deformed alkali halide crystals

    International Nuclear Information System (INIS)

    Dzhumanov, S.; Tulepbergenov, S.K.; Shunkeev, K.Sh.

    2002-01-01

    In the paper molecular component of two-knot auto-localized exciton (TALE) occupying centrosymmetric state in alkali halide crystal cubic lattice with local D 2h symmetry is considered. In is suggested that the symmetry lowering of forming small radius auto-localized exciton (ALE) is realizing in order configuration transformation by the scenario: multi-knot continual ALE (with O h symmetry)→six-halide ALE (with O h symmetry)→TALE (with O h symmetry) or by the scenario O h →D 2h . Then for TALE with local D 2h symmetry normal molecular ion shifts are considered as well

  17. Genetic polymorphism and average life expectancy of exposed individuals and their offspring

    International Nuclear Information System (INIS)

    Telnov, V.I.; Sotnik, N.V.

    2004-01-01

    A population-genetic analysis of the average life expectancy (ALE) was performed for nuclear workers at the Mayak Production Association exposed to external and internal radiation over a wide dose range and their off spring. A methodical approach was proposed to determine ALE for individuals with different genotypes and estimate ALE in the population based on genotype distribution. The analysis has revealed significant shifts in the Hp type distribution of genetic markers in the nuclear workers off spring, especially an increased proportion of Hp 2-2 at parents external g-irradiation doses over 2Gy by the conception time

  18. Investigación y análisis de la tecnología PLC, desde la perspectiva del mercado ecuatoriano

    OpenAIRE

    Rivera Pacheco, Andrea Catalina

    2008-01-01

    Las Comunicaciones por Línea de Poder (PLC) aprovechan el tendido eléctrico existente como un medio de intercambio de señales para propósitos de comunicación. Consiste en acondicionar parte de las actuales infraestructuras eléctricas para que puedan transmitir señales regulares de baja frecuencia y otras por encima de la banda de 1 MHz, sin que se vea afectado el rendimiento eléctrico. Las señales de baja frecuencia (50 ó 60 Hz, según la red eléctrica) son las encargadas de la transmisión ...

  19. Development of a biomimetic enzyme-linked immunosorbent assay based on molecularly imprinted polymers on paper for the detection of carbaryl.

    Science.gov (United States)

    Zhang, Can; Cui, Hanyu; Han, Yufeng; Yu, Fangfang; Shi, Xiaoman

    2018-02-01

    A biomimetic enzyme-linked immunosorbent assay (BELISA) which was based on molecularly imprinted polymers on paper (MIPs-paper) with specific recognition was developed. As a detector, the surface of paper was modified with γ-MAPS by hydrolytic action and anchored the MIP layer on γ-MAPS modified-paper by copolymerization to construct the artificial antibody Through a series of experimentation and verification, we successful got the MIPs-paper and established BELISA for the detection of carbaryl. The development of MIPs-paper based on BELISA was applied to detect carbaryl in real samples and validated by an enzyme-linked immunosorbent assay (ELISA) based on anti-carbaryl biological antibody. The results of these two methods (BELISA and ELISA) were well correlated (R 2 =0.944). The established method of MIPs-paper BELISA exhibits the advantages of low cost, higher stability and being re-generable, which can be applied as a convenient tool for the fast and efficient detection of carbaryl. Copyright © 2017. Published by Elsevier Ltd.

  20. Reinforcement of smoking and drinking: tobacco marketing strategies linked with alcohol in the United States.

    Science.gov (United States)

    Jiang, Nan; Ling, Pamela M

    2011-10-01

    We investigated tobacco companies' knowledge about concurrent use of tobacco and alcohol, their marketing strategies linking cigarettes with alcohol, and the benefits tobacco companies sought from these marketing activities. We performed systematic searches on previously secret tobacco industry documents, and we summarized the themes and contexts of relevant search results. Tobacco company research confirmed the association between tobacco use and alcohol use. Tobacco companies explored promotional strategies linking cigarettes and alcohol, such as jointly sponsoring special events with alcohol companies to lower the cost of sponsorships, increase consumer appeal, reinforce brand identity, and generate increased cigarette sales. They also pursued promotions that tied cigarette sales to alcohol purchases, and cigarette promotional events frequently featured alcohol discounts or encouraged alcohol use. Tobacco companies' numerous marketing strategies linking cigarettes with alcohol may have reinforced the use of both substances. Because using tobacco and alcohol together makes it harder to quit smoking, policies prohibiting tobacco sales and promotion in establishments where alcohol is served and sold might mitigate this effect. Smoking cessation programs should address the effect that alcohol consumption has on tobacco use.

  1. Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats.

    Science.gov (United States)

    El-Boshy, Mohamed; Ashshi, Ahmad; Gaith, Mazen; Qusty, Naeem; Bokhary, Thalat; AlTaweel, Nagwa; Abdelhady, Mohamed

    2017-05-01

    Our objective was to explore the protective effect of artichoke leaf extract (ALE) against cadmium (Cd) toxicity-induced oxidative organ damage in rats. Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2-4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl 2 , 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks. After treatment with Cd, the liver and kidney malondialdehyde (MDA) increased significantly compared with the control rats. The sera interleukin (IL)-1β, tumor necrosis factor (TNF-α), and IL-10, liver transaminase, urea, creatinine, and peripheral neutrophil count were significantly increased in Cd-exposed rats compared to the control group. The reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) decreased in the liver and kidney in Cd-exposed group. In combination treatment, Cd and ALE significantly improved immune response, an antioxidant system, and hepatorenal function with a significant decline in MDA. In conclusion, ALE ameliorates the immunosuppressive and hepatorenal oxidative injury stimulated by Cd in rats. These results suggest that artichoke has shown promising effects against adverse effects of Cd toxicity.

  2. Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation.

    Science.gov (United States)

    Kim, Young-Kyu; Koppula, Sushruta; Shim, Do-Wan; In, Eun-Jung; Kwak, Su-Bin; Kim, Myong-Ki; Yu, Sang-Hyeun; Lee, Kwang-Ho; Kang, Tae-Bong

    2018-01-01

    Arctium lappa (A. lappa) , Compositae, is considered a potential source of nutrition and is used as a traditional medicine in East Asian countries for centuries. Although several studies have shown its biological activities as an anti-inflammatory agent, there have been no reports on A. lappa with regard to regulatory role in inflammasome activation. The purpose of this study was to investigate the inhibitory effects of A. lappa extract (ALE) on NLRP3 inflammasome activation and explore the underlying mechanisms. We found that ALE inhibited IL-1 β secretion from NLRP3 inflammasome activated bone marrow derived macrophages but not that secreted by NLRC4 and AIM2 inflammasomes activation. Mechanistic studies revealed that ALE suppressed the ATPase activity of purified NLRP3 and reduced mitochondrial reactive oxygen species (mROS) generated during NLRP3 activation. Therefore, the inhibitory effect of ALE on NLRP3 inflammasome might be attributed to its ability to inhibit the NLRP3 ATPase function and attenuated the mROS during inflammasome activation. In addition, ALE significantly reduced the LPS-induced increase of plasma IL-1 β in mouse peritonitis model. These results provide evidence of novel anti-inflammatory mechanisms of A. lappa , which might be used for therapeutic applications in the treatment of NLRP3 inflammasome-associated inflammatory disorders.

  3. The link between benign prostatic hyperplasia and prostate cancer

    DEFF Research Database (Denmark)

    Ørsted, David Dynnes; Bojesen, Stig E

    2013-01-01

    Benign prostatic hyperplasia (BPH) and prostate cancer are among the most common diseases of the prostate gland and represent significant burdens for patients and health-care systems in many countries. The two diseases share traits such as hormone-dependent growth and response to antiandrogen...... therapy. Furthermore, risk factors such as prostate inflammation and metabolic disruption have key roles in the development of both diseases. Despite these commonalities, BPH and prostate cancer exhibit important differences in terms of histology and localization. Although large-scale epidemiological...... studies have shown that men with BPH have an increased risk of prostate cancer and prostate-cancer-related mortality, it remains unclear whether this association reflects a causal link, shared risk factors or pathophysiological mechanisms, or detection bias upon statistical analysis. Establishing BPH...

  4. Multi-Functional Fibre-Optic Microwave Links

    DEFF Research Database (Denmark)

    Gliese, Ulrik Bo

    1998-01-01

    The multi-functionality of microwave links based on remote heterodyne detection of signals from a dual-frequency laser transmitter is discussed and experimentally demonstrated in this paper. Typically, direct detection in conjunction with optical intensity modulation is used to implement fibre......-optic microwave links. The resulting links are inherently transparent and mainly used for signal transmission. As opposed to direct detection links, remote heterodyne detection links can directly perform functionalities such as modulation, frequency conversion, and transparent signal recovery in addition...

  5. "Vzhledově neodolatelný", ale "povahově nesnesitelný", czyli o niektórych czeskich przymiotnikach i przysłówkach

    Directory of Open Access Journals (Sweden)

    Irena Bogocz

    2015-12-01

    Full Text Available Visually irresistible, but essentially unbearable, or on some of Czech adjectives and adverbs The present contribution from the field of comparative Slavonic word for­ mation deals with a specific feature of the Czech language, namely its frequent (in comparison to other Slavonic tongues use of adjectives of passive possibility (impossibility, which in Czech usually assume the suffix -telný (or ne-telný, and of so-called viewpoint adverbs, like cenově, vzhledově, and povahově. The article’s main focus is the situation of Czech from a diachronic perspective. Emphasis is also placed upon the differences between particular Slavonic languages as well as in academic traditions of linguistics in particular Slavonic nations. These theoretical remarks are illustrated with examples of different languages conveying the same message with means that are either synthetic (one word, e.g. adjective or adverb or analytic (multi-word phrase.   Vzhledově neodolatelný, ale povahově nesnesitelný, czyli o niektórych czeskich przymiotnikach i przysłówkach Celem artykułu jest zwrócenie uwagi na specyficzną sytuację języka czeskiego, polegającą na wysokiej częstotliwości (w porównaniu z językiem polskim lub innymi językami słowiańskimi tworzenia i używania przymiotników (niemożliwościowych z formantem -telný (ew. ne–telný oraz tzw. przysłówka względu typu cenově, vzhledově, povahově itd. Odwołując się do odpowiedniej literatury fachowej, autorka przedstawia omawiany temat w ujęciu diachronicznym, zwracając równocześnie uwagę na różnice w konkretnych językach słowiańskich oraz w interpretacjach prezentowanego zjawiska w tradycji lin­gwistycznej poszczególnych narodów słowiańskich. Uwagi natury teoretycznej ilustrowane są przykładami wyrażania tej samej treści – w zależności od danego języka – w sposób syntetyczny (w postaci przymiotnika/przysłówka albo analityczny (w postaci konstrukcji

  6. Distribution of physical therapists working on public and private establishments in different levels of complexity of health care in Brazil.

    Science.gov (United States)

    Costa, Larissa R; Costa, José L R; Oishi, Jorge; Driusso, Patricia

    2012-01-01

    The Brazilian Health System is organized on a regional and hierarchical form with three levels of complexity of health care. The Primary Care represents the first element of a continuing health care process, complemented by specialized actions. However, the centrality of the specialized care is still a problem in Brazil, especially in the private sector. Studies on the distribution of professionals in the health system allowing the formulation of appropriate policies are needed. To investigate the distribution of physical therapists in the levels of complexity of health care and between public and private establishments, according to data from the National Register of Health Service Providers (NRHSP). A descriptive cross-sectional study was performed considering NRHSP-national bank data collected in March 2010 and demographic census 2010 data. Data were analyzed through descriptive statistics techniques. We identified 53,181 registries of physical therapists, 60% linked to the private sector. Only 13% of all entries were linked to primary care. The predominance in specialized care occurred in the public sector (65%) and private sector (100%). The specialized establishments of private sector linked to the southeast region (16,043) were the main sites of physical therapists. Only the public sector in the south had a majority in the Primary Care. When considering the sizes of the cities, there is focus on specialist care in bigger cities. This study identified the concentration of physical therapists in the specialized care, mostly in metropolis and big cities and in the private sector, with restricted to participation in the primary care.

  7. Photodissociative Cross-Linking of Non-covalent Peptide-Peptide Ion Complexes in the Gas Phase

    Science.gov (United States)

    Nguyen, Huong T. H.; Andrikopoulos, Prokopis C.; Rulíšek, Lubomír; Shaffer, Christopher J.; Tureček, František

    2018-05-01

    We report a gas-phase UV photodissociation study investigating non-covalent interactions between neutral hydrophobic pentapeptides and peptide ions incorporating a diazirine-tagged photoleucine residue. Phenylalanine (Phe) and proline (Pro) were chosen as the conformation-affecting residues that were incorporated into a small library of neutral pentapeptides. Gas-phase ion-molecule complexes of these peptides with photo-labeled pentapeptides were subjected to photodissociation. Selective photocleavage of the diazirine ring at 355 nm formed short-lived carbene intermediates that underwent cross-linking by insertion into H-X bonds of the target peptide. The cross-link positions were established from collision-induced dissociation tandem mass spectra (CID-MS3) providing sequence information on the covalent adducts. Effects of the amino acid residue (Pro or Phe) and its position in the target peptide sequence were evaluated. For proline-containing peptides, interactions resulting in covalent cross-links in these complexes became more prominent as proline was moved towards the C-terminus of the target peptide sequence. The photocross-linking yields of phenylalanine-containing peptides depended on the position of both phenylalanine and photoleucine. Density functional theory calculations were used to assign structures of low-energy conformers of the (GLPMG + GLL*LK + H)+ complex. Born-Oppenheimer molecular dynamics trajectory calculations were used to capture the thermal motion in the complexes within 100 ps and determine close contacts between the incipient carbene and the H-X bonds in the target peptide. This provided atomic-level resolution of potential cross-links that aided spectra interpretation and was in agreement with experimental data. [Figure not available: see fulltext.

  8. Evaluation of a Pilot Surveillance System: Health and Environment Linked for Information Exchange in Atlanta (HELIX-Atlanta)

    Science.gov (United States)

    Meyer, P.; Shire, J.; Qualters, Judy; Daley, Randolph; Fiero, Leslie Todorov; Autry, Andy; Avchen, Rachel; Stock, Allison; Correa, Adolofo; Siffel, Csaba; hide

    2007-01-01

    CDC and its partners established the Health and Environment Linked for Information Exchange, Atlanta (HELIX-Atlanta) demonstration project, to develop linking and analysis methods that could be used by the National Environmental Public Health Tracking (EPHT) Network. Initiated in October 2003, the Metropolitan Atlanta-based collaborative conducted four projects: asthma and particulate air pollution, birth defects and ozone and particulate air pollution, childhood leukemia and traffic emissions, and children's blood lead testing and neighborhood risk factors for lead poisoning. This report provides an overview of the HELIX-Atlanta projects' goals, methods and outcomes. We discuss priority attributes and common issues and challenges and offer recommendations for implementation of the nascent national environmental public health tracking network.

  9. ITK optical links backup document

    CERN Document Server

    Huffman, B T; The ATLAS collaboration; Flick, T; Ye, J

    2013-01-01

    This document describes the proposed optical links to be used for the ITK in the phase II upgrade. The current R&D for optical links pursued in the Versatile Link group is reviewed. In particular the results demonstrating the radiation tolerance of all the on-detector components are documented. The bandwidth requirements and the resulting numerology are given.

  10. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... for young people, parents and teachers, and the media with links to our latest research findings and news updates. Read on to Learn the Link between ... to this site at: http://www.drugabuse.gov/news-events/public-education-projects/learn-link-drugs-hiv . ... Social Media Send the message to young people and to ...

  11. Let's "Downscale" Linked Data

    NARCIS (Netherlands)

    Gueret, C.D.M.; de Boer, V.; Schlobach, K.S.

    2014-01-01

    Open data policies and linked data publication are powerful tools for increasing transparency, participatory governance, and accountability. The linked data community proudly emphasizes the economic and societal impact such technology shows. But a closer look proves that the design and deployment of

  12. Let's "Downscale" Linked Data

    NARCIS (Netherlands)

    Gueret, Christophe; de Boer, Victor; Schlobach, Stefan

    2014-01-01

    Open data policies and linked data publication are powerful tools for increasing transparency, participatory governance, and accountability. A closer look at linked data technologies, however, proves that their design and deployment exclude the majority of the world’s population. It will take small

  13. Analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices.

    Science.gov (United States)

    Perera, Handunge Kumudu Irani; Handuwalage, Charith Sandaruwan

    2015-06-09

    Protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. Glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method. Methanol extracts of thirteen plants including nine antidiabetic plants and three spices were used. Lysozyme and fructose were incubated at 37 °C in the presence or absence of different concentrations of plant extracts up to 31 days. Standard glycation inhibitor aminoguanidine and other appropriate controls were included. A recently established sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE) method was used to detect the products of protein cross-linking in the incubation mixtures. High molecular weight protein products representing the dimer, trimer and tetramer of lysozyme were detected in the presence of fructose. Among the nine antidiabetic plants, seven showed glycation induced protein cross-linking inhibitory effects namely Ficus racemosa (FR) stem bark, Gymnema sylvestre (GS) leaves, Musa paradisiaca (MP) yam, Phyllanthus debilis (PD) whole plant, Phyllanthus emblica (PE) fruit, Pterocarpus marsupium (PM) latex and Tinospora cordifolia (TC) leaves. Inhibition observed with Coccinia grandis (CG) leaves and Strychnos potatorum (SP) seeds were much low. Leaves of Gymnema lactiferum (GL), the plant without known antidiabetic effects showed the lowest inhibition. All three spices namely Coriandrum sativum (CS) seeds, Cinnamomum zeylanicum (CZ) bark and Syzygium aromaticum (SA) flower buds showed cross-link inhibitory effects with higher effects in CS and SA. PD, PE, PM, CS and SA showed almost complete inhibition on the formation of cross-linking with 25 μg/ml extracts. Methanol extracts of PD, PE, PM, CS and SA have shown promising inhibitory effects on glycation induced protein cross-linking.

  14. The SAIL databank: linking multiple health and social care datasets

    Directory of Open Access Journals (Sweden)

    Ford David V

    2009-01-01

    Full Text Available Abstract Background Vast amounts of data are collected about patients and service users in the course of health and social care service delivery. Electronic data systems for patient records have the potential to revolutionise service delivery and research. But in order to achieve this, it is essential that the ability to link the data at the individual record level be retained whilst adhering to the principles of information governance. The SAIL (Secure Anonymised Information Linkage databank has been established using disparate datasets, and over 500 million records from multiple health and social care service providers have been loaded to date, with further growth in progress. Methods Having established the infrastructure of the databank, the aim of this work was to develop and implement an accurate matching process to enable the assignment of a unique Anonymous Linking Field (ALF to person-based records to make the databank ready for record-linkage research studies. An SQL-based matching algorithm (MACRAL, Matching Algorithm for Consistent Results in Anonymised Linkage was developed for this purpose. Firstly the suitability of using a valid NHS number as the basis of a unique identifier was assessed using MACRAL. Secondly, MACRAL was applied in turn to match primary care, secondary care and social services datasets to the NHS Administrative Register (NHSAR, to assess the efficacy of this process, and the optimum matching technique. Results The validation of using the NHS number yielded specificity values > 99.8% and sensitivity values > 94.6% using probabilistic record linkage (PRL at the 50% threshold, and error rates were Conclusion With the infrastructure that has been put in place, the reliable matching process that has been developed enables an ALF to be consistently allocated to records in the databank. The SAIL databank represents a research-ready platform for record-linkage studies.

  15. Research and Practice of Active Learning in Engineering Education

    NARCIS (Netherlands)

    Graaf, de Erik; Saunders-Smits, Gillian; Nieweg, Michael

    2005-01-01

    Since 2001, the international network Active Learning in Engineering education (ALE) organized a series of international workshops on innovation of engineering education. The papers in this book are selected to reflect the state of the art, based on contributions to the 2005 ALE workshop in Holland.

  16. Weierstrass polynomials for links

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    1997-01-01

    There is a natural way of identifying links in3-space with polynomial covering spaces over thecircle. Thereby any link in 3-space can be definedby a Weierstrass polynomial over the circle. Theequivalence relation for covering spaces over thecircle is, however, completely different from...

  17. FORMELE DE TURISM CARE VALORIFICĂ COMPONENTELE ATRACTIVE ALE DESTINAŢIEI

    Directory of Open Access Journals (Sweden)

    Ina CAVCALIUC

    2015-12-01

    Full Text Available Atractivitatea unei destinaţii depinde de resursele turistice existente şi de modul în care acestea sunt percepute de turişti. Componentele ofertei turistice nu au aceeaşi importanţă în cadrul ierarhiei stabilite de consumatori în vederea satisfacerii motivaţiilor turistice, deoarece permanent există posibilitatea de a le completa, substitui sau compensa unele cu altele, de a modifica ponderea importanţei fiecăruia în cadrul consumului turistic. Componentele de atractivitate a teritoriului stimulează interesul potenţialilor turişti, pentru a le vizita, satisfăcând diferite motivaţii turistice. FORMS OF TOURISM THAT IMPROVE ATTRACTIVE COMPONENTS OF THE DESTINATIONThe attractiveness of a destination depends on the existing tourism resources and how they are perceived by tourists. Tourism supply components have not the same importance in the hierarchy established by consumer in order to satisfy its travel motivations, because there is the possibility of complete, substitute or offset each other, to modify the importance of each in the share of tourism consumption. Attractive components of the territory stimulate interest of potential tourists to visit them, satisfying different travel motivations. 

  18. Establishing a national resource: a health informatics collection to maintain the legacy of health informatics development.

    Science.gov (United States)

    Ellis, Beverley; Roberts, Jean; Cooper, Helen

    2007-01-01

    This case study report of the establishment of a national repository of multi-media materials describes the creation process, the challenges faced in putting it into operation and the opportunities for the future. The initial resource has been incorporated under standard library and knowledge management practices. A collaborative action research method was used with active experts in the domain to determine the requirements and priorities for further development. The National Health Informatics Collection (NatHIC) is now accessible and the further issues are being addressed by inclusion in future University and NHS strategic plans. Ultimately the Collection will link with other facilities that contribute to the description and maintenance of effective informatics in support of health globally. The issues raised about the National Health Informatics Collection as established in the UK have resonance with the challenges of capturing the overall historic development of an emerging discipline in any country.

  19. Establishment of human papillomavirus infection requires cell cycle progression.

    Directory of Open Access Journals (Sweden)

    Dohun Pyeon

    2009-02-01

    Full Text Available Human papillomaviruses (HPVs are DNA viruses associated with major human cancers. As such there is a strong interest in developing new means, such as vaccines and microbicides, to prevent HPV infections. Developing the latter requires a better understanding of the infectious life cycle of HPVs. The HPV infectious life cycle is closely linked to the differentiation state of the stratified epithelium it infects, with progeny virus only made in the terminally differentiating suprabasal compartment. It has long been recognized that HPV must first establish its infection within the basal layer of stratified epithelium, but why this is the case has not been understood. In part this restriction might reflect specificity of expression of entry receptors. However, this hypothesis could not fully explain the differentiation restriction of HPV infection, since many cell types can be infected with HPVs in monolayer cell culture. Here, we used chemical biology approaches to reveal that cell cycle progression through mitosis is critical for HPV infection. Using infectious HPV16 particles containing the intact viral genome, G1-synchronized human keratinocytes as hosts, and early viral gene expression as a readout for infection, we learned that the recipient cell must enter M phase (mitosis for HPV infection to take place. Late M phase inhibitors had no effect on infection, whereas G1, S, G2, and early M phase cell cycle inhibitors efficiently prevented infection. We conclude that host cells need to pass through early prophase for successful onset of transcription of the HPV encapsidated genes. These findings provide one reason why HPVs initially establish infections in the basal compartment of stratified epithelia. Only this compartment of the epithelium contains cells progressing through the cell cycle, and therefore it is only in these cells that HPVs can establish their infection. By defining a major condition for cell susceptibility to HPV infection, these

  20. Integrin-linked kinase: a Scaffold protein unique among its ilk.

    Science.gov (United States)

    Dagnino, Lina

    2011-06-01

    Integrin-linked kinase (ILK) is a scaffolding protein with central roles in tissue development and homeostasis. Much debate has focused on whether ILK is a bona fide or a pseudo- kinase. This aspect of ILK function has been complicated by the large volumes of conflicting observations obtained from a wide variety of experimental approaches, from in vitro models, to analyses in invertebrates and in mammals. Key findings in support or against the notion that ILK is catalytically active are summarized. The importance of ILK as an adaptor protein is well established, and defining its role as a signaling hub will be the next key step to understand its distinct biological roles across tissues and species.

  1. Disentangling plant establishment in sandy coastal systems: biotic and abiotic factors that determine Allagoptera arenaria (Arecaceae germination

    Directory of Open Access Journals (Sweden)

    Luis Fernando Tavares de Menezes

    2017-10-01

    Full Text Available ABSTRACT Germination rate and establishment success of plants in harsh environments depend on the ability of seeds to withstand unfavorable environmental conditions and avoid predators. Brazilian coastal plains, known as restinga, are subject to environmental factors that seriously limit plant establishment and survival (e.g. salinity, desiccation, oligotrophy, flooding, high temperature and radiation levels. We tested, both in field and laboratory experiments, conditions for germination and establishment of Allagoptera arenaria, a palm tree often found in restinga ecosystems of southeastern Brazil, and which have a principal role in plant community dynamics. Our results showed that the absence of mesocarp, high radiation exposure, and temperature were the main drivers of seed germination. In the field, the highest germination rate was linked to nude seeds buried in open areas. High temperatures and/or predation damaged seeds that remained on the soil surface, especially if they were close to the mother plant and alongside dung piles made by dispersers. Under controlled conditions, seeds exhibited optimum germination at 35 ºC. Therefore, the germination and establishment of A. arenaria depend as much on environmental conditions as on a network of interactions including vertebrates and invertebrates, which allow this species to colonize harsh, open areas in restinga ecosystems.

  2. Organization of extracting molecules of the diamide type: link with the extracting properties?

    International Nuclear Information System (INIS)

    Meridiano, Y.

    2009-02-01

    The aim of these studies is to establish a link between the different organizations of diamide extractants (used in the DIAMEX process) and their extracting properties. The effects of the key parameters leading the liquid-liquid extraction (concentration of extractant, nature of solute, activity of the aqueous phase, nature of the diluent and temperature) are studied: 1) at the supramolecular scale, with the characterization of the extractant organizations by vapor-pressure osmometry (VPO) and small angle neutron and X-ray scattering (SANS/SAXS) experiments; 2) at the molecular scale, with the quantification of the extracted solutes (water, nitric acid, metal nitrate) and the determination of extracted complexes stoichiometries by electro-spray mass spectrometry (ESI-MS) experiments. The DMDOHEMA molecule acts as a classical surfactant and forms aggregates of the reverse micelle type. Taking into account the established supramolecular diagrams, a quantitative link between the extractants structures and their extracting properties has been brought to light. To model the europium nitrate extraction, two approaches have been developed: - an approach based on mass action laws. Extractions equilibria have been proposed taking into account the supramolecular speciation; - an innovative approach considering the extracted ions as adsorbed on a specific surface of the extractant molecule which depends on the extractant organization state. The ion extraction can be considered as a sum of isotherms corresponding to the different states of organization. This approach allows to compare the extraction efficiency of an extracting molecule as a function of its organization state. (author)

  3. Japan Link Center (JaLC): link management and DOI assignment for Japanese electronic scholarly contents

    Science.gov (United States)

    Kato, Takafumi; Tsuchiya, Eri; Kubota, Soichi; Miyagawa, Yoshiyuki

    JST, cooperated with several national institutes, is currently developing “Japan Link Center”, which manages Japanese electronic scholarly contents (journal articles, books, dissertations etc.) in an integrated fashion using Digital Object Identifier (DOI). Japan Link Center will manage metadata and whereabouts information of the contents in the digital environment and provide domestic and international linking information, cite/cited information to activate dissemination of S&T information, furthermore, to strengthen transmission of S&T information from Japan. Japan Link Center is expected to be appointed as the 9th DOI registration agency (RA) in the world by the International DOI Foundation (IDF) this spring.

  4. The Missing Link

    DEFF Research Database (Denmark)

    Schultz, Laura Luise

    2014-01-01

    Paper presented at A Valentine to Gertrude Stein. The Reception of Gertrude Stein in the Arts and Humanities, held at the University of Copenhagen 8. - 10. May 2014, in collaboration with the universities of Ghent and Linköping......Paper presented at A Valentine to Gertrude Stein. The Reception of Gertrude Stein in the Arts and Humanities, held at the University of Copenhagen 8. - 10. May 2014, in collaboration with the universities of Ghent and Linköping...

  5. Link til hjemmesider

    DEFF Research Database (Denmark)

    Bervild, Charlotte

    2015-01-01

    Link til læringsobjekter/undervisningsportalhttp://videoportal.ucc.dk/channel/10492641/charlotte-bervilds-undervisninghttp://videoportal.ucc.dk/video/8248508/3d-printer-v-lektor-charlotte-bervildFotoblog:http://charlottebervild.blogspot.dk/2008/10/fotocollager-af-charlotte-bervild.html......Link til læringsobjekter/undervisningsportalhttp://videoportal.ucc.dk/channel/10492641/charlotte-bervilds-undervisninghttp://videoportal.ucc.dk/video/8248508/3d-printer-v-lektor-charlotte-bervildFotoblog:http://charlottebervild.blogspot.dk/2008/10/fotocollager-af-charlotte-bervild.html...

  6. LERC-SLAM - THE NASA LEWIS RESEARCH CENTER SATELLITE LINK ATTENUATION MODEL PROGRAM (MACINTOSH VERSION)

    Science.gov (United States)

    Manning, R. M.

    1994-01-01

    The frequency and intensity of rain attenuation affecting the communication between a satellite and an earth terminal is an important consideration in planning satellite links. The NASA Lewis Research Center Satellite Link Attenuation Model Program (LeRC-SLAM) provides a static and dynamic statistical assessment of the impact of rain attenuation on a communications link established between an earth terminal and a geosynchronous satellite. The program is designed for use in the specification, design and assessment of satellite links for any terminal location in the continental United States. The basis for LeRC-SLAM is the ACTS Rain Attenuation Prediction Model, which uses a log-normal cumulative probability distribution to describe the random process of rain attenuation on satellite links. The derivation of the statistics for the rainrate process at the specified terminal location relies on long term rainfall records compiled by the U.S. Weather Service during time periods of up to 55 years in length. The theory of extreme value statistics is also utilized. The user provides 1) the longitudinal position of the satellite in geosynchronous orbit, 2) the geographical position of the earth terminal in terms of latitude and longitude, 3) the height above sea level of the terminal site, 4) the yearly average rainfall at the terminal site, and 5) the operating frequency of the communications link (within 1 to 1000 GHz, inclusive). Based on the yearly average rainfall at the terminal location, LeRC-SLAM calculates the relevant rain statistics for the site using an internal data base. The program then generates rain attenuation data for the satellite link. This data includes a description of the static (i.e., yearly) attenuation process, an evaluation of the cumulative probability distribution for attenuation effects, and an evaluation of the probability of fades below selected fade depths. In addition, LeRC-SLAM calculates the elevation and azimuth angles of the terminal

  7. Exploring the link between intrinsic motivation and quality

    Science.gov (United States)

    Christy, Steven M.

    1992-12-01

    This thesis proposes that it is workers' intrinsic motivation that leads them to produce quality work. It reviews two different types of evidence- expert opinion and empirical studies--to attempt to evaluate a link between intrinsic motivation and work quality. The thesis reviews the works of Total Quality writers and behavioral scientists for any connection they might have made between intrinsic motivation and quality. The thesis then looks at the works of Deming and his followers in an attempt to establish a match between Deming's motivational assumptions and the four task rewards in the Thomas/Tymon model of intrinsic motivation: choice, competence, meaningfulness, and progress. Based upon this analysis, it is proposed that the four Thomas/Tymon task rewards are a promising theoretical foundation for explaining the motivational basis of quality for workers in Total Quality organizations.

  8. From the genome to the phenome and back: linking genes with human brain function and structure using genetically informed neuroimaging

    DEFF Research Database (Denmark)

    Siebner, H R; Callicott, J H; Sommer, T

    2009-01-01

    In recent years, an array of brain mapping techniques has been successfully employed to link individual differences in circuit function or structure in the living human brain with individual variations in the human genome. Several proof-of-principle studies provided converging evidence that brain...... imaging can establish important links between genes and behaviour. The overarching goal is to use genetically informed brain imaging to pinpoint neurobiological mechanisms that contribute to behavioural intermediate phenotypes or disease states. This special issue on "Linking Genes to Brain Function...... in Health and Disease" provides an overview over how the "imaging genetics" approach is currently applied in the various fields of systems neuroscience to reveal the genetic underpinnings of complex behaviours and brain diseases. While the rapidly emerging field of imaging genetics holds great promise...

  9. Startup activities of established Finnish companies

    OpenAIRE

    Saalasti, Sini

    2016-01-01

    Established companies have collaborated with startups for decades in order to enhance their capabilities in technology and innovation. However, in the recent years, the changes in the business environment have induced established companies to increase their collaboration with startups. Thus, startup activities of established companies have become a timely phenomenon. This study explores the startup activities of established companies by analyzing all the activity established companies conduct...

  10. Establishing a Set of Macroeconomic Factors Explaining Variation Over Time of Performance in Business Sectors

    Directory of Open Access Journals (Sweden)

    Audrius Dzikevičius

    2016-06-01

    Full Text Available With increasing competitiveness of companies and business sectors in the domestic markets of Lithuania, economic units are frequently confronted with the lack of methods for more detailed analysis of external factors explaining the variation over time of corporate financial indicators. The analysis or forecasting of financial indicators is usually linked with the development of a stock market or undertaken to estimate the probability of bankruptcy. However, there is a lack of studies aimed at identifying links between macroeconomic factors and financial performance indicators and explaining their variation over time. To serve that purpose, the factors of the macroeconomic environment that are most significant for certain economic activities have been identified and analysed to enable explaining the variation over time patterns of corporate financial indicators. The analysis covers economic performance, i.e. financial performance indicators and their links with macroeconomic factors, in 89 business sectors of Lithuania at a three-digit level of NACE 2 ed. The findings of the research indicate that the unemployment level in the country, the volume of export and import and the GDP are the most important macroeconomic factors that can be used to forecast different profitability, financial leverage, liquidity and other financial performance indicators of individual business sectors or companies. The research has not unfolded any significant differences between business sectors therefore the above factors are considered generic macroeconomic factors enabling to explain financial performance indicators of the 89 business sectors. Hence, special attention has to be paid to identifying and analysing specific factors and assessing the causal link. When established, the set of such factors provides a framework for building of a model to forecast business sector financial indicators.

  11. Linking the microscopic view of chemistry to real-life experiences: Intertextuality in a high-school science classroom

    Science.gov (United States)

    Wu, Hsin-Kai

    2003-11-01

    Chemistry learning involves establishing conceptual relationships among macroscopic, microscopic, and symbolic representations. Employing the notion of intertextuality to conceptualize these relationships, this study investigates how class members interactionally construct meanings of chemical representations by connecting them to real-life experiences and how the teachers' content knowledge shapes their ways to coconstruct intertextual links with students. Multiple sources of data were collected over 7 weeks with a participation of 25 eleventh graders, an experienced teacher, and a student teacher. An examination of classroom discourse shows that the intertextual links between the microscopic view of chemistry and students' real-life experiences could be initiated by students and instigated by the teachers. The teachers applied several discursive strategies to scaffold students building meaningful links based on their prior knowledge and experiences. Additionally, the experienced teacher with stronger content knowledge tended to present links in both dialogic and monologic discourses. Yet, the relatively limited content knowledge did not necessarily constrain the student teacher's interactions with students. The findings of this study provide a backdrop for further research to explore how chemistry is learned and taught in a class through the social constructivist lens.

  12. Experience is Instrumental in Tuning a Link Between Language and Cognition: Evidence from 6- to 7- Month-Old Infants' Object Categorization.

    Science.gov (United States)

    Perszyk, Danielle R; Waxman, Sandra R

    2017-04-19

    At birth, infants not only prefer listening to human vocalizations, but also have begun to link these vocalizations to cognition: For infants as young as three months of age, listening to human language supports object categorization, a core cognitive capacity. This precocious link is initially broad: At 3 and 4 months, vocalizations of both humans and nonhuman primates support categorization. But by 6 months, infants have narrowed the link: Only human vocalizations support object categorization. Here we ask what guides infants as they tune their initially broad link to a more precise one, engaged only by the vocalizations of our species. Across three studies, we use a novel exposure paradigm to examine the effects of experience. We document that merely exposing infants to nonhuman primate vocalizations enables infants to preserve the early-established link between this signal and categorization. In contrast, exposing infants to backward speech - a signal that fails to support categorization at any age - offers no such advantage. Our findings reveal the power of early experience as infants specify which signals, from an initially broad set, they will continue to link to cognition.

  13. Spatial variability of biotic and abiotic tree establishment constraints across a treeline ecotone in the Alaska range.

    Science.gov (United States)

    Stueve, Kirk M; Isaacs, Rachel E; Tyrrell, Lucy E; Densmore, Roseann V

    2011-02-01

    Throughout interior Alaska (U.S.A.), a gradual warming trend in mean monthly temperatures occurred over the last few decades (approximatlely 2-4 degrees C). The accompanying increases in woody vegetation at many alpine treeline (hereafter treeline) locations provided an opportunity to examine how biotic and abiotic local site conditions interact to control tree establishment patterns during warming. We devised a landscape ecological approach to investigate these relationships at an undisturbed treeline in the Alaska Range. We identified treeline changes between 1953 (aerial photography) and 2005 (satellite imagery) in a geographic information system (GIS) and linked them with corresponding local site conditions derived from digital terrain data, ancillary climate data, and distance to 1953 trees. Logistic regressions enabled us to rank the importance of local site conditions in controlling tree establishment. We discovered a spatial transition in the importance of tree establishment controls. The biotic variable (proximity to 1953 trees) was the most important tree establishment predictor below the upper tree limit, providing evidence of response lags with the abiotic setting and suggesting that tree establishment is rarely in equilibrium with the physical environment or responding directly to warming. Elevation and winter sun exposure were important predictors of tree establishment at the upper tree limit, but proximity to trees persisted as an important tertiary predictor, indicating that tree establishment may achieve equilibrium with the physical environment. However, even here, influences from the biotic variable may obscure unequivocal correlations with the abiotic setting (including temperature). Future treeline expansion will likely be patchy and challenging to predict without considering the spatial variability of influences from biotic and abiotic local site conditions.

  14. [Sex-linked juvenile retinoschisis].

    Science.gov (United States)

    François, P; Turut, P; Soltysik, C; Hache, J C

    1976-02-01

    About 13 observations of sexe linked juvenile retinoschisis, the authors describe the ophthalmoscopic, fluorographic and functional aspects of the disease whose caracteristics are:--its sexe linked recessive heredity; --its clinical characterestics associating: a microcystic macular degeneration, peripheral retinal lesions, vitreous body alterations, --an electroretinogram of the negative type.

  15. ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability

    DEFF Research Database (Denmark)

    Haahr, Peter; Borgermann, Nikoline; Guo, Xiaohu

    2018-01-01

    Deubiquitylating enzymes (DUBs) enhance the dynamics of the versatile ubiquitin (Ub) code by reversing and regulating cellular ubiquitylation processes at multiple levels. Here we discovered that the uncharacterized human protein ZUFSP (zinc finger with UFM1-specific peptidase domain protein/C6orf......113/ZUP1), which has been annotated as a potentially inactive UFM1 protease, and its fission yeast homolog Mug105 define a previously unrecognized class of evolutionarily conserved cysteine protease DUBs. Human ZUFSP selectively interacts with and cleaves long K63-linked poly-Ub chains by means...... establish ZUFSP as a new type of linkage-selective cysteine peptidase DUB with a role in genome maintenance pathways....

  16. Collecting and Connecting the Dots: Leveraging Technology to Enhance the Collection of Information and the Dissemination of Intelligence

    Science.gov (United States)

    2009-09-01

    Terrorism Task Force (JTTF), Joint, Terrorism Analysis Center (JTAC), domestic intelligence 16. PRICE CODE 17. SECURITY CLASSIFICAT ION OF REPORT...on the event and share this with law enforcement partners.  A second case involved a suspicious m ale at a local Starbucks . The m ale was wearing

  17. Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits.

    Science.gov (United States)

    Beurel, E; Jope, R S

    2014-12-16

    Suicide is one of the leading causes of death in the United States, yet it remains difficult to understand the mechanistic provocations and to intervene therapeutically. Stress is recognized as a frequent precursor to suicide. Psychological stress is well established to cause activation of the inflammatory response, including causing neuroinflammation, an increase of inflammatory molecules in the central nervous system (CNS). Neuroinflammation is increasingly recognized as affecting many aspects of CNS functions and behaviors. In particular, much evidence demonstrates that inflammatory markers are elevated in traits that have been linked to suicidal behavior, including aggression, impulsivity and depression. Lithium is recognized as significantly reducing suicidal behavior, is anti-inflammatory and diminishes aggression, impulsivity and depression traits, each of which is associated with elevated inflammation. The anti-inflammatory effects of lithium result from its inhibition of glycogen synthase kinase-3 (GSK3). GSK3 has been demonstrated to strongly promote inflammation, aggressive behavior in rodents and depression-like behaviors in rodents, whereas regulation of impulsivity by GSK3 has not yet been investigated. Altogether, evidence is building supporting the hypothesis that stress activates GSK3, which in turn promotes inflammation, and that inflammation is linked to behaviors associated with suicide, including particularly aggression, impulsivity and depression. Further investigation of these links may provide a clearer understanding of the causes of suicidal behavior and provide leads for the development of effective preventative interventions, which may include inhibitors of GSK3.

  18. Stronger links between CERN and South Africa

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    iThemba LABS in South Africa is a research facility that, about twenty years ago, started to treat oncological patients with particle beams. Its collaboration with CERN has steadily grown over the years. After becoming a member of the ALICE and ATLAS Collaborations, today iThemba LABS is planning to buy a new medical-use cyclotron proton facility, and is seeking to strengthen its links with CERN and Europe also in this field by collaborating with ENLIGHT. The cyclotron will be dedicated to proton therapy – the only one of its kind in the southern hemisphere.   iThemba LABS (Laboratory for Accelerator Based Sciences) was established near Cape Town, South Africa almost 50 years ago as the continent's base for the Southern Universities Nuclear Institute that is now used mainly for material science research. In the 1980s, iThemba built a 200MeV cyclotron and, following its construction, in the early 1990s branched into a new scientific field: radiation and nuclear medicine. ...

  19. Materializing the web of linked data

    CERN Document Server

    Konstantinou, Nikolaos

    2015-01-01

    This book explains the Linked Data domain by adopting a bottom-up approach: it introduces the fundamental Semantic Web technologies and building blocks, which are then combined into methodologies and end-to-end examples for publishing datasets as Linked Data, and use cases that harness scholarly information and sensor data. It presents how Linked Data is used for web-scale data integration, information management and search. Special emphasis is given to the publication of Linked Data from relational databases as well as from real-time sensor data streams. The authors also trace the transformation from the document-based World Wide Web into a Web of Data. Materializing the Web of Linked Data is addressed to researchers and professionals studying software technologies, tools and approaches that drive the Linked Data ecosystem, and the Web in general.

  20. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells.

    Science.gov (United States)

    Li, Huige; Xia, Ning; Brausch, Isolde; Yao, Ying; Förstermann, Ulrich

    2004-09-01

    Nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature. Hence, an enhanced expression of eNOS in response to pharmacological interventions could provide protection against cardiovascular diseases. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs), an artichoke leaf extract (ALE) increased the activity of the human eNOS promoter (determined by luciferase reporter gene assay). An organic subfraction from ALE was more potent in this respect than the crude extract, whereas an aqueous subfraction of ALE was without effect. ALE and the organic subfraction thereof also increased eNOS mRNA expression (measured by an RNase protection assay) and eNOS protein expression (determined by Western blot) both in EA.hy 926 cells and in native HUVECs. NO production (measured by NO-ozone chemiluminescence) was increased by both extracts. In organ chamber experiments, ex vivo incubation (18 h) of rat aortic rings with the organic subfraction of ALE enhanced the NO-mediated vasodilator response to acetylcholine, indicating that the up-regulated eNOS remained functional. Caffeoylquinic acids and flavonoids are two major groups of constituents of ALE. Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, whereas the caffeoylquinic acids cynarin and chlorogenic acid were without effect. Thus, in addition to the lipid-lowering and antioxidant properties of artichoke, an increase in eNOS gene transcription may also contribute to its beneficial cardiovascular profile. Artichoke flavonoids are likely to represent the active ingredients mediating eNOS up-regulation.

  1. Remote operation over low speed, high latency links; Operacao remota confiavel usando circuitos de baixa velocidade e alta latencia

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Marcelo D.; Nunes, Ildemar P. [Transportadora Brasileira Gasoduto Bolivia Brasil S.A., Rio de Janeiro, RJ (Brazil)

    2004-07-01

    Remote Control and monitoring of a compressor station with more than 3000 tags can be a hard task to accomplish over a low speed satellite link. This paper presents Datasync, an application specially developed to provide acceptable performance levels over a VSAT link. One of its main features is to enable the establishment of communication dead bands. The dead bands can be altered while the application is running (no restart is needed), so that the operator is able to increase a specific tag's dead band immediately after detecting that it is reporting too many exceptions, which would cause an increase on the traffic and response times. (author)

  2. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats

    Directory of Open Access Journals (Sweden)

    Chen-Rui Li

    2013-01-01

    Full Text Available Radix Scutellariae (RS, a medicinal herb, is extensively employed in traditional Chinese medicines and modern herbal prescriptions. Two major flavonoids in RS were known to induce osteoblastic differentiation and inhibit osteoclast differentiation, respectively. This study aimed to investigate the effect of Radix Scutellariae extract (RSE against bone loss induced by mechanical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model (TS was established to determine the effect of RSE on bone mineral density and bone microarchitecture. Treatment of RSE at 50 mg/kg/day and alendronate (ALE at 2 mg/kg/day as positive control for 42 days significantly increased the bone mineral density and mechanical strength compared with TS group. Enhanced bone turnover markers by TS treatment were attenuated by RSE and ALE administration. Deterioration of bone trabecula induced by TS was prevented. Moreover, both treatments counteracted the reduction of bone volume fraction, trabecular thickness and number, and connectivity density. In conclusion, RSE was demonstrated for the first time to prevent osteoporosis induced by TS treatment, which suggests the potential application of RSE in the treatment of disuse-induced osteoporosis.

  3. A Study of WLAN Campus in an Educational Establishment

    Directory of Open Access Journals (Sweden)

    Taghareed Abdul-Hameed

    2009-10-01

    Full Text Available the main aim of campus network is to efficiently separate, share and access knowledge among its users. The big demand of such systems of distributed knowledge networks is to be able to handle advanced applications which are the end-user requirements. The main goal of this study is to assess the ability of WLAN campus to dealing with applications request of end users in education establishments and network achievement under different conditions of operation. The study has been conducted in two stages: the first stage was accomplished by conducting a survey, using the Student Village network at Anglia Ruskin University as a case study; the main aim was to determine end-use requirements, gather information about the nature applications running by users and get a view about the likely future applications. The second stage was achieved by conducting experiments to evaluate the WLAN campus network performance under various different scenarios: impact of handover from Access Point (AP to another AP on end-user link performance, network performance in different usage time and network performance in different weather conditions.

  4. The development of retrosynthetic glycan libraries to profile and classify the human serum N-linked glycome.

    Science.gov (United States)

    Kronewitter, Scott R; An, Hyun Joo; de Leoz, Maria Lorna; Lebrilla, Carlito B; Miyamoto, Suzanne; Leiserowitz, Gary S

    2009-06-01

    Annotation of the human serum N-linked glycome is a formidable challenge but is necessary for disease marker discovery. A new theoretical glycan library was constructed and proposed to provide all possible glycan compositions in serum. It was developed based on established glycobiology and retrosynthetic state-transition networks. We find that at least 331 compositions are possible in the serum N-linked glycome. By pairing the theoretical glycan mass library with a high mass accuracy and high-resolution MS, human serum glycans were effectively profiled. Correct isotopic envelope deconvolution to monoisotopic masses and the high mass accuracy instruments drastically reduced the amount of false composition assignments. The high throughput capacity enabled by this library permitted the rapid glycan profiling of large control populations. With the use of the library, a human serum glycan mass profile was developed from 46 healthy individuals. This paper presents a theoretical N-linked glycan mass library that was used for accurate high-throughput human serum glycan profiling. Rapid methods for evaluating a patient's glycome are instrumental for studying glycan-based markers.

  5. Microprocessor-controlled CAMAC data link module

    International Nuclear Information System (INIS)

    Potter, J.M.

    1978-05-01

    Communication between the central control computer and remote, satellite data-acquisition/control stations at the Clinton P. Anderson Meson Physics Facility (LAMPF) is presently accomplished through the use of CAMAC-based Data Link modules. With the advent of the microprocessor, a new philosophy for digital data communications has evolved. Data Link modules containing microprocessor controllers provide link management and communication network protocol through algorithms executed in the Data Link microprocessor. 13 figures

  6. Website Policies / Important Links | Data Explorer

    Science.gov (United States)

    Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important ) Publication Date (oldest first) Close Clear All Find DOE Data Explorer Website Policies / Important Links Science | Office of Scientific and Technical Information Website Policies / Important Links * Site Map

  7. Linked data for libraries, archives and museums how to clean, link and publish your metadata

    CERN Document Server

    Hooland, Seth van

    2014-01-01

    This highly practical handbook teaches you how to unlock the value of your existing metadata through cleaning, reconciliation, enrichment and linking and how to streamline the process of new metadata creation. Libraries, archives and museums are facing up to the challenge of providing access to fast growing collections whilst managing cuts to budgets. Key to this is the creation, linking and publishing of good quality metadata as Linked Data that will allow their collections to be discovered, accessed and disseminated in a sustainable manner. This highly practical handbook teaches you how to unlock the value of your existing metadata through cleaning, reconciliation, enrichment and linking and how to streamline the process of new metadata creation. Metadata experts Seth van Hooland and Ruben Verborgh introduce the key concepts of metadata standards and Linked Data and how they can be practically applied to existing metadata, giving readers the tools and understanding to achieve maximum results with limited re...

  8. COPD and stroke: are systemic inflammation and oxidative stress the missing links?

    Science.gov (United States)

    Austin, Victoria; Crack, Peter J; Bozinovski, Steven; Miller, Alyson A; Vlahos, Ross

    2016-07-01

    Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis of COPD, acute exacerbations of COPD (AECOPD) and cardiovascular comorbidities associated with COPD, in particular stroke. We also highlight and discuss the potential mechanisms underpinning the link between COPD and stroke, with a particular focus on the roles of systemic inflammation and oxidative stress. © 2016 The Author(s).

  9. Linking diversity and distribution to understand biodiversity gradients and inform conservation assessments

    Directory of Open Access Journals (Sweden)

    Fabricio Villalobos

    2014-03-01

    Full Text Available Broad-scale patterns of species richness result from differential coexistence among species in distinct regions of the globe, determined by the species’ ranges and their properties such as size, shape and location. Thus, species richness and ranges are inherently linked. These two biodiversity features also yield primary information for conservation assessments. However, species richness and range size have been usually studied separately and no formal analytical link has been established. In my PhD thesis, I applied and extended a recently developed conceptual and methodological framework to study geographical association among species and similarity among sites. This range–diversity framework, along with stochastic simulation modelling, allowed me to jointly evaluate the relationship between diversity and distribution, to infer potential processes underlying composite patterns of phyllostomid bats, and to use this approach to inform conservation assessments for the Mexican avifauna. I highlight the need to explore composite patterns for understanding biodiversity patterns and show how combining diversity and distributional data can help describe complex biogeographical patterns, providing a transparent and explicit application for initial conservation assessments.

  10. Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking

    DEFF Research Database (Denmark)

    Hartmann-Petersen, R; Tanaka, K; Hendil, K B

    2001-01-01

    and substrate specificity. Among the approximately 18 subunits of PA700 regulator, six are ATPases. The ATPases presumably recognize, unfold, and translocate substrates into the interior of the 26S proteasome. It is generally believed that the ATPases form a hexameric ring. By means of chemical cross......-linking, immunoprecipitation, and blotting, we have determined that the ATPases are organized in the order S6-S6'-S10b-S8-S4-S7. Additionally, we found cross-links between the ATPase S10b and the 20S proteasome subunit alpha6. Together with the previously known interaction between S8 and alpha1 and between S4 and alpha7......, these data establish the relative orientations of ATPases with respect to the 20S proteasome....

  11. Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation

    Directory of Open Access Journals (Sweden)

    Young-Kyu Kim

    2018-01-01

    Full Text Available Arctium lappa (A. lappa, Compositae, is considered a potential source of nutrition and is used as a traditional medicine in East Asian countries for centuries. Although several studies have shown its biological activities as an anti-inflammatory agent, there have been no reports on A. lappa with regard to regulatory role in inflammasome activation. The purpose of this study was to investigate the inhibitory effects of A. lappa extract (ALE on NLRP3 inflammasome activation and explore the underlying mechanisms. We found that ALE inhibited IL-1β secretion from NLRP3 inflammasome activated bone marrow derived macrophages but not that secreted by NLRC4 and AIM2 inflammasomes activation. Mechanistic studies revealed that ALE suppressed the ATPase activity of purified NLRP3 and reduced mitochondrial reactive oxygen species (mROS generated during NLRP3 activation. Therefore, the inhibitory effect of ALE on NLRP3 inflammasome might be attributed to its ability to inhibit the NLRP3 ATPase function and attenuated the mROS during inflammasome activation. In addition, ALE significantly reduced the LPS-induced increase of plasma IL-1β in mouse peritonitis model. These results provide evidence of novel anti-inflammatory mechanisms of A. lappa, which might be used for therapeutic applications in the treatment of NLRP3 inflammasome-associated inflammatory disorders.

  12. Photo-Oxidative Stress-Driven Mutagenesis and Adaptive Evolution on the Marine Diatom Phaeodactylum tricornutum for Enhanced Carotenoid Accumulation

    Directory of Open Access Journals (Sweden)

    Zhiqian Yi

    2015-09-01

    Full Text Available Marine diatoms have recently gained much attention as they are expected to be a promising resource for sustainable production of bioactive compounds such as carotenoids and biofuels as a future clean energy solution. To develop photosynthetic cell factories, it is important to improve diatoms for value-added products. In this study, we utilized UVC radiation to induce mutations in the marine diatom Phaeodactylum tricornutum and screened strains with enhanced accumulation of neutral lipids and carotenoids. Adaptive laboratory evolution (ALE was also used in parallel to develop altered phenotypic and biological functions in P. tricornutum and it was reported for the first time that ALE was successfully applied on diatoms for the enhancement of growth performance and productivity of value-added carotenoids to date. Liquid chromatography-mass spectrometry (LC-MS was utilized to study the composition of major pigments in the wild type P. tricornutum, UV mutants and ALE strains. UVC radiated strains exhibited higher accumulation of fucoxanthin as well as neutral lipids compared to their wild type counterpart. In addition to UV mutagenesis, P. tricornutum strains developed by ALE also yielded enhanced biomass production and fucoxanthin accumulation under combined red and blue light. In short, both UV mutagenesis and ALE appeared as an effective approach to developing desired phenotypes in the marine diatoms via electromagnetic radiation-induced oxidative stress.

  13. Characterization of the degree of cross-linking in radiation cross-linked low and high density polyethylenes

    International Nuclear Information System (INIS)

    Posselt, K.; Haedrich, W.

    1986-01-01

    In practice the cross-linking of irradiated polyethylene is mostly characterized by solubility and thermomechanical data. The irradiation of samples of a LDPE and a HDPE yields very different gel-dose curves. But for a quantitative comparison the complicated connection between the gel values and the corresponding densities of cross-links, especially the dependence on the initial molecular size distribution, has to take into consideration. The analysis of the solubility data according to the statistical theory of cross-linking developed by Inokuti and Saito shows that at equal doses in both investigated PE types in spite of the different gel values nearly the same densities of cross-links are present. That result is confirmed by the densities of cross-links determined from stress-strain measurements at 423 K. (author)

  14. Linking GHG Emission Trading Systems and Markets

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    Several different types of links are possible between different GHG-mitigation systems. These include: Linking two or more emission trading schemes so that emissions trading can occur both within and between different schemes ('direct links'); and Linking emission trading systems to registries/mechanisms and systems that generate offsets from project based mechanisms or from direct purchases/transfers of AAUs ('indirect links').

  15. The Versatile Link Demo Board (VLDB)

    International Nuclear Information System (INIS)

    Lesma, R. Martín; Alessio, F.; Barbosa, J.; Baron, S.; Caplan, C.; Leitao, P.; Porret, D.; Wyllie, K.; Pecoraro, C.

    2017-01-01

    The Versatile Link Demonstrator Board (VLDB) is the evaluation kit for the radiation-hard Optical Link ecosystem, which provides a 4.8 Gbps data transfer link for communication between front-end (FE) and back-end (BE) of the High Energy Physics experiments. It gathers the Versatile link main radiation-hard custom Application-Specific Integrated Circuits (ASICs) and modules: GBTx, GBT-SCA and VTRx/VTTx plus the FeastMP, a radiation-hard in-house designed DC-DC converter. This board is the first design allowing system-level tests of the Link with a complete interconnection of the constitutive components, allowing data acquisition, control and monitoring of FE devices with the GBT-SCA pair.

  16. Restricted linking of emissions trading systems

    NARCIS (Netherlands)

    Schneider, Lambert; Lazarus, Michael; Lee, Carrie; Asselt, van Harro

    2017-01-01

    With over 17 emissions trading systems (ETSs) now in place across four continents, interest in linking ETSs is growing. Linking ETSs offers economic, political, and administrative benefits. It also faces major challenges. Linking can affect overall ambition, financial flows, and the location and

  17. Radiation-induced linking reactions in polyethylene

    International Nuclear Information System (INIS)

    Zoepfl, F.J.

    1983-01-01

    Three types of measurements are reported relating to chemical reactions in polyethylene induced by ionizing radiation: 1) viscometric and low-angle laser light scattering measurements to determine the effect of a radical scavenger on the yield of links; 2) calorimetric measurements to determine the effect of radiation-induced linking on the melting behavior of polyethylene; and 3) high-resolution solution carbon 13 nuclear magnetic resonance (NMR) spectrometry measurements to determine the nature of the links and the method of their formation. The NMR results present the first direct detection of radiation-induced long-chain branching (Y links) in polyethylene, and place an apparent upper limit on the yield of H-shaped crosslinks that are formed when polyethylene is irradiated to low absorbed doses. The effect of radiation-induced linking on the melting behavior of polyethylene was examined using differential scanning calorimetry (DSC). It was found that radiation-induced links do not change the heat of fusion of polythylene crystals, but decrease the melt entropy and increase the fold surface free energy per unit area of the crystals. The carbon 13 NMR results demonstrate that long-chain branches (Y links) are formed much more frequently than H-shaped crosslinks at low absorbed doses. The Y links are produced by reactions of alkyl free radicals with terminal vinyl groups in polyethylene

  18. Establishment of a computer-controlled retroreflection measurement system at the National Metrology Institute of Turkey (UME)

    International Nuclear Information System (INIS)

    Samedov, Farhad; Celikel, Oguz; Bazkir, Ozcan

    2005-01-01

    In order to characterize photometric properties of retroreflectors, a fully automated retroreflector measurement system is designed in National Metrology Institute of Turkey (UME). The system is composed of a lighting projector, a goniometer, filter radiometers, 100 dB transimpedance amplifiers, and 24-bit resolution analog-digital converter card with a special software. The established system provides a new calibration capability to determine the luminous intensity and retroreflection coefficients of the retroreflective materials with the expanded uncertainties of 1.07% and 1.13% (k=2), respectively. The traceability in retroreflection measurements was linked to the detector-based photometric scale of UME

  19. Bartonella spp. - a chance to establish One Health concepts in veterinary and human medicine.

    Science.gov (United States)

    Regier, Yvonne; O Rourke, Fiona; Kempf, Volkhard A J

    2016-05-10

    Infectious diseases remain a remarkable health threat for humans and animals. In the past, the epidemiology, etiology and pathology of infectious agents affecting humans and animals have mostly been investigated in separate studies. However, it is evident, that combined approaches are needed to understand geographical distribution, transmission and infection biology of "zoonotic agents". The genus Bartonella represents a congenial example of the synergistic benefits that can arise from such combined approaches: Bartonella spp. infect a broad variety of animals, are linked with a constantly increasing number of human diseases and are transmitted via arthropod vectors. As a result, the genus Bartonella is predestined to play a pivotal role in establishing a One Health concept combining veterinary and human medicine.

  20. Optimisation of the link volume for weakest link failure prediction in NBG-18 nuclear graphite

    International Nuclear Information System (INIS)

    Hindley, Michael P.; Groenwold, Albert A.; Blaine, Deborah C.; Becker, Thorsten H.

    2014-01-01

    This paper describes the process for approximating the optimal size of a link volume required for weakest link failure calculation in nuclear graphite, with NBG-18 used as an example. As part of the failure methodology, the link volume is defined in terms of two grouping criteria. The first criterion is a factor of the maximum grain size and the second criterion is a function of an equivalent stress limit. A methodology for approximating these grouping criteria is presented. The failure methodology employs finite element analysis (FEA) in order to predict the failure load, at 50% probability of failure. The average experimental failure load, as determined for 26 test geometries, is used to evaluate the accuracy of the weakest link failure calculations. The influence of the two grouping criteria on the failure load prediction is evaluated by defining an error in prediction across all test cases. Mathematical optimisation is used to find the minimum error across a range of test case failure predictions. This minimum error is shown to deliver the most accurate failure prediction across a whole range of components, although some test cases in the range predict conservative failure load. The mathematical optimisation objective function is penalised to account for non-conservative prediction of the failure load for any test case. The optimisation is repeated and a link volume found for conservative failure prediction. The failure prediction for each test case is evaluated, in detail, for the proposed link volumes. Based on the analysis, link design volumes for NBG-18 are recommended for either accurate or conservative failure prediction

  1. Biomine: predicting links between biological entities using network models of heterogeneous databases

    Directory of Open Access Journals (Sweden)

    Eronen Lauri

    2012-06-01

    Full Text Available Abstract Background Biological databases contain large amounts of data concerning the functions and associations of genes and proteins. Integration of data from several such databases into a single repository can aid the discovery of previously unknown connections spanning multiple types of relationships and databases. Results Biomine is a system that integrates cross-references from several biological databases into a graph model with multiple types of edges, such as protein interactions, gene-disease associations and gene ontology annotations. Edges are weighted based on their type, reliability, and informativeness. We present Biomine and evaluate its performance in link prediction, where the goal is to predict pairs of nodes that will be connected in the future, based on current data. In particular, we formulate protein interaction prediction and disease gene prioritization tasks as instances of link prediction. The predictions are based on a proximity measure computed on the integrated graph. We consider and experiment with several such measures, and perform a parameter optimization procedure where different edge types are weighted to optimize link prediction accuracy. We also propose a novel method for disease-gene prioritization, defined as finding a subset of candidate genes that cluster together in the graph. We experimentally evaluate Biomine by predicting future annotations in the source databases and prioritizing lists of putative disease genes. Conclusions The experimental results show that Biomine has strong potential for predicting links when a set of selected candidate links is available. The predictions obtained using the entire Biomine dataset are shown to clearly outperform ones obtained using any single source of data alone, when different types of links are suitably weighted. In the gene prioritization task, an established reference set of disease-associated genes is useful, but the results show that under favorable

  2. Reinforcement of Smoking and Drinking: Tobacco Marketing Strategies Linked With Alcohol in the United States

    Science.gov (United States)

    Jiang, Nan

    2011-01-01

    Objectives. We investigated tobacco companies’ knowledge about concurrent use of tobacco and alcohol, their marketing strategies linking cigarettes with alcohol, and the benefits tobacco companies sought from these marketing activities. Methods. We performed systematic searches on previously secret tobacco industry documents, and we summarized the themes and contexts of relevant search results. Results. Tobacco company research confirmed the association between tobacco use and alcohol use. Tobacco companies explored promotional strategies linking cigarettes and alcohol, such as jointly sponsoring special events with alcohol companies to lower the cost of sponsorships, increase consumer appeal, reinforce brand identity, and generate increased cigarette sales. They also pursued promotions that tied cigarette sales to alcohol purchases, and cigarette promotional events frequently featured alcohol discounts or encouraged alcohol use. Conclusions. Tobacco companies’ numerous marketing strategies linking cigarettes with alcohol may have reinforced the use of both substances. Because using tobacco and alcohol together makes it harder to quit smoking, policies prohibiting tobacco sales and promotion in establishments where alcohol is served and sold might mitigate this effect. Smoking cessation programs should address the effect that alcohol consumption has on tobacco use. PMID:21852637

  3. Examining the Link Between Public Transit Use and Active Commuting

    Directory of Open Access Journals (Sweden)

    Melissa Bopp

    2015-04-01

    Full Text Available Background: An established relationship exists between public transportation (PT use and physical activity. However, there is limited literature that examines the link between PT use and active commuting (AC behavior. This study examines this link to determine if PT users commute more by active modes. Methods: A volunteer, convenience sample of adults (n = 748 completed an online survey about AC/PT patterns, demographic, psychosocial, community and environmental factors. t-test compared differences between PT riders and non-PT riders. Binary logistic regression analyses examined the effect of multiple factors on AC and a full logistic regression model was conducted to examine AC. Results: Non-PT riders (n = 596 reported less AC than PT riders. There were several significant relationships with AC for demographic, interpersonal, worksite, community and environmental factors when considering PT use. The logistic multivariate analysis for included age, number of children and perceived distance to work as negative predictors and PT use, feelings of bad weather and lack of on-street bike lanes as a barrier to AC, perceived behavioral control and spouse AC were positive predictors. Conclusions: This study revealed the complex relationship between AC and PT use. Further research should investigate how AC and public transit use are related.

  4. Establishing endangered species recovery criteria using predictive simulation modeling

    Science.gov (United States)

    McGowan, Conor P.; Catlin, Daniel H.; Shaffer, Terry L.; Gratto-Trevor, Cheri L.; Aron, Carol

    2014-01-01

    Listing a species under the Endangered Species Act (ESA) and developing a recovery plan requires U.S. Fish and Wildlife Service to establish specific and measurable criteria for delisting. Generally, species are listed because they face (or are perceived to face) elevated risk of extinction due to issues such as habitat loss, invasive species, or other factors. Recovery plans identify recovery criteria that reduce extinction risk to an acceptable level. It logically follows that the recovery criteria, the defined conditions for removing a species from ESA protections, need to be closely related to extinction risk. Extinction probability is a population parameter estimated with a model that uses current demographic information to project the population into the future over a number of replicates, calculating the proportion of replicated populations that go extinct. We simulated extinction probabilities of piping plovers in the Great Plains and estimated the relationship between extinction probability and various demographic parameters. We tested the fit of regression models linking initial abundance, productivity, or population growth rate to extinction risk, and then, using the regression parameter estimates, determined the conditions required to reduce extinction probability to some pre-defined acceptable threshold. Binomial regression models with mean population growth rate and the natural log of initial abundance were the best predictors of extinction probability 50 years into the future. For example, based on our regression models, an initial abundance of approximately 2400 females with an expected mean population growth rate of 1.0 will limit extinction risk for piping plovers in the Great Plains to less than 0.048. Our method provides a straightforward way of developing specific and measurable recovery criteria linked directly to the core issue of extinction risk. Published by Elsevier Ltd.

  5. Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin.

    Science.gov (United States)

    Nakaishi, Masayuki; Kajino, Kazunori; Ikesue, Masahiro; Hagiwara, Yoshiaki; Kuwahara, Maki; Mitani, Hiroaki; Horikoshi-Sakuraba, Yuko; Segawa, Tatsuya; Kon, Shigeyuki; Maeda, Masahiro; Wang, Tegexibaiyin; Abe, Masaaki; Yokoyama, Masayoshi; Hino, Okio

    2007-05-01

    By representational difference analysis, we previously identified the rat Erc (Expressed in renal carcinoma) gene that was more abundantly expressed in the renal carcinoma tissues of Eker rats than in the rat normal kidney. In this study, we raised antibodies against the amino-terminal portion of the rat Erc, and demonstrated the existence of a approximately 30-kDa secretory form in the supernatant of cultured cells derived from rat renal carcinoma. The enzyme-linked immunosorbent assay (ELISA) system using these antibodies detected high concentrations of this form in the sera of Eker rats bearing renal carcinomas, and in the sera of rats transplanted with mesothelioma cells. Mesothelin, a human homolog of the rat Erc, was recently reported to be a serum marker of malignant mesothelioma. The prognosis of mesothelioma is poor and there is no effective treatment at present. There are several rat model systems of mesothelioma that may be promising tools in the development of an antimesothelioma treatment. We hope our ELISA to detect the soluble form of rat Erc/Mesothelin is useful in the rat model system to exploit the antimesothelioma therapy to be used in human cases.

  6. REDEN: Named Entity Linking in Digital Literary Editions Using Linked Data Sets

    Directory of Open Access Journals (Sweden)

    Carmen Brando

    2016-07-01

    Full Text Available This paper proposes a graph-based Named Entity Linking (NEL algorithm named REDEN for the disambiguation of authors’ names in French literary criticism texts and scientific essays from the 19th and early 20th centuries. The algorithm is described and evaluated according to the two phases of NEL as reported in current state of the art, namely, candidate retrieval and candidate selection. REDEN leverages knowledge from different Linked Data sources in order to select candidates for each author mention, subsequently crawls data from other Linked Data sets using equivalence links (e.g., owl:sameAs, and, finally, fuses graphs of homologous individuals into a non-redundant graph well-suited for graph centrality calculation; the resulting graph is used for choosing the best referent. The REDEN algorithm is distributed in open-source and follows current standards in digital editions (TEI and semantic Web (RDF. Its integration into an editorial workflow of digital editions in Digital humanities and cultural heritage projects is entirely plausible. Experiments are conducted along with the corresponding error analysis in order to test our approach and to help us to study the weaknesses and strengths of our algorithm, thereby to further improvements of REDEN.

  7. Characterization of a bombesin receptor on Swiss mouse 3T3 cells by affinity cross-linking

    International Nuclear Information System (INIS)

    Sinnett-Smith, J.; Zachary, I.; Rozengurt, E.

    1988-01-01

    We have previously identified by chemical cross-linking a cell surface protein in Swiss 3T3 cells of apparent Mr 75,000-85,000, which may represent a major component of the receptor for peptides of the bombesin family in these cells. Because bombesin-like peptides may interact with other cell surface molecules, it was important to establish the correlation between receptor binding and functions of this complex and further characterize the Mr 75,000-85,000 cross-linked protein. Detailed time courses carried out at different temperatures demonstrated that the Mr 75,000-85,000 affinity-labelled band was the earliest cross-linked complex detected in Swiss 3T3 cells incubated with 125I-labelled gastrin-releasing peptide (125I-GRP). Furthermore, the ability of various nonradioactive bombesin agonists and antagonists to block the formation of the Mr 75,000-85,000 cross-linked complex correlated extremely well (r = 0.994) with the relative capacity of these peptides to inhibit 125I-GRP specific binding. Pretreatment with unlabelled GRP for up to 6 h caused only a slight decrease in both specific 125I-GRP binding and the affinity labelling of the Mr 75,000-85,000 protein. We also show that the cross-linked complex is a glycoprotein. First, solubilized affinity labelled Mr 75,000-85,000 complex applied to wheat germ lectin-sepharose columns was eluted by addition of 0.3 M N-acetyl-D-glucosamine. Second, treatment with endo-beta-N-acetylglucosaminidase F reduced the apparent molecular weight of the affinity-labelled band from 75,000-85,000 to 43,000, indicating the presence of N-linked oligosaccharide groups

  8. Manual de LinkedIn

    OpenAIRE

    Blázquez Sevilla, Alegría; Borrás Gené, Oriol

    2016-01-01

    Manual básico sobre la red profesional LinkedIn, donde se analiza la red y se explica a fondo cómo crear un perfil y gestionarlo. Incluye información sobre las diferentes secciones características de la red LinkedIn y ofrece consejos para la correcta gestión de un perfil, buscando su mejor rendimiento.

  9. The HANDSS-55 Linking Equipment

    International Nuclear Information System (INIS)

    Crosby, S.

    2001-01-01

    The Bucket Translation Unit (BTU) and the Drum Handler are two of the HANDSS-55 subsystems identified as linking components. Both subsystems link other modules together by moving material to or from another module

  10. LERC-SLAM - THE NASA LEWIS RESEARCH CENTER SATELLITE LINK ATTENUATION MODEL PROGRAM (IBM PC VERSION)

    Science.gov (United States)

    Manning, R. M.

    1994-01-01

    The frequency and intensity of rain attenuation affecting the communication between a satellite and an earth terminal is an important consideration in planning satellite links. The NASA Lewis Research Center Satellite Link Attenuation Model Program (LeRC-SLAM) provides a static and dynamic statistical assessment of the impact of rain attenuation on a communications link established between an earth terminal and a geosynchronous satellite. The program is designed for use in the specification, design and assessment of satellite links for any terminal location in the continental United States. The basis for LeRC-SLAM is the ACTS Rain Attenuation Prediction Model, which uses a log-normal cumulative probability distribution to describe the random process of rain attenuation on satellite links. The derivation of the statistics for the rainrate process at the specified terminal location relies on long term rainfall records compiled by the U.S. Weather Service during time periods of up to 55 years in length. The theory of extreme value statistics is also utilized. The user provides 1) the longitudinal position of the satellite in geosynchronous orbit, 2) the geographical position of the earth terminal in terms of latitude and longitude, 3) the height above sea level of the terminal site, 4) the yearly average rainfall at the terminal site, and 5) the operating frequency of the communications link (within 1 to 1000 GHz, inclusive). Based on the yearly average rainfall at the terminal location, LeRC-SLAM calculates the relevant rain statistics for the site using an internal data base. The program then generates rain attenuation data for the satellite link. This data includes a description of the static (i.e., yearly) attenuation process, an evaluation of the cumulative probability distribution for attenuation effects, and an evaluation of the probability of fades below selected fade depths. In addition, LeRC-SLAM calculates the elevation and azimuth angles of the terminal

  11. Fast Link Adaptation for MIMO-OFDM

    DEFF Research Database (Denmark)

    Jensen, Tobias Lindstrøm; Kant, Shashi; Wehinger, Joachim

    2010-01-01

    We investigate link-quality metrics (LQMs) based on raw bit-error-rate, effective signal-to-interference-plus-noise ratio, and mutual information (MI) for the purpose of fast link adaptation (LA) in communication systems employing orthogonal frequency-division multiplexing and multiple-input–mult......We investigate link-quality metrics (LQMs) based on raw bit-error-rate, effective signal-to-interference-plus-noise ratio, and mutual information (MI) for the purpose of fast link adaptation (LA) in communication systems employing orthogonal frequency-division multiplexing and multiple...

  12. Drug Establishments Current Registration Site

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Drug Establishments Current Registration Site (DECRS) is a database of current information submitted by drug firms to register establishments (facilities) which...

  13. The importance of link evidence in Wikipedia

    NARCIS (Netherlands)

    Kamps, J.; Koolen, M.

    2008-01-01

    Wikipedia is one of the most popular information sources on the Web. The free encyclopedia is densely linked. The link structure in Wikipedia differs from the Web at large: internal links in Wikipedia are typically based on words naturally occurring in a page, and link to another semantically

  14. Shuttle/TDRSS modelling and link simulation study

    Science.gov (United States)

    Braun, W. R.; Mckenzie, T. M.; Biederman, L.; Lindsey, W. C.

    1979-01-01

    A Shuttle/TDRSS S-band and Ku-band link simulation package called LinCsim was developed for the evaluation of link performance for specific Shuttle signal designs. The link models were described in detail and the transmitter distortion parameters or user constraints were carefully defined. The overall link degradation (excluding hardware degradations) relative to an ideal BPSK channel were given for various sets of user constraint values. The performance sensitivity to each individual user constraint was then illustrated. The effect of excessive Spacelab clock jitter on the return link BER performance was also investigated as was the problem of subcarrier recovery for the K-band Shuttle return link signal.

  15. Investigation of thin oxide layer removal from Si substrates using an SiO2 atomic layer etching approach: the importance of the reactivity of the substrate

    International Nuclear Information System (INIS)

    Metzler, Dominik; Oehrlein, Gottlieb S; Li, Chen; Lai, C Steven; Hudson, Eric A

    2017-01-01

    The evaluation of a plasma-based atomic layer etching (ALE) approach for native oxide surface removal from Si substrates is described. Objectives include removal of the native oxide while minimizing substrate damage, surface residues and substrate loss. Oxide thicknesses were measured using in situ ellipsometry and surface chemistry was analyzed by x-ray photoelectron spectroscopy. The cyclic ALE approach when used for removal of native oxide SiO 2 from a Si substrate did not remove native oxide to the extent required. This is due to the high reactivity of the silicon substrate during the low-energy (<40 eV) ion bombardment phase of the cyclic ALE approach which leads to reoxidation of the silicon surface. A modified process, which used continuously biased Ar plasma with periodic CF 4 injection, achieved significant oxygen removal from the Si surface, with some residual carbon and fluorine. A subsequent H 2 /Ar plasma exposure successfully removed residual carbon and fluorine while passivating the silicon surface. The combined treatment reduced oxygen and carbon levels to about half compared to as received silicon surfaces. The downside of this process sequence is a net loss of about 40 Å of Si. A generic insight of this work is the importance of the substrate and final surface chemistry in addition to precise etch control of the target film for ALE processes. By a fluorocarbon-based ALE technique, thin SiO 2 layer removal at the Ångstrom level can be precisely performed from an inert substrate, e.g. a thick SiO 2 layer. However, from a reactive substrate, like Si, complete removal of the thin SiO 2 layer is prevented by the high reactivity of low energy Ar + ion bombarded Si. The Si surfaces are reoxidized during the ALE ion bombardment etch step, even for very clean and ultra-low O 2 process conditions. (paper)

  16. The urban density premium across establishments

    OpenAIRE

    R. Jason Faberman; Matthew Freedman

    2013-01-01

    We use longitudinal microdata to estimate the urban density premium for U.S. establishments, controlling for observed establishment characteristics and dynamic establishment behavior. Consistent with previous studies, we estimate a density premium between 6 and 10 percent, even after controlling for establishment composition, local skill mix, and the endogeneity of location choice. More importantly, we find that the estimated density premium is realized almost entirely at birth and is constan...

  17. Helically linked mirror arrangement

    International Nuclear Information System (INIS)

    Ranjan, P.

    1986-08-01

    A scheme is described for helical linking of mirror sections, which endeavors to combine the better features of toroidal and mirror devices by eliminating the longitudinal loss of mirror machines, having moderately high average β and steady state operation. This scheme is aimed at a device, with closed magnetic surfaces having rotational transform for equilibrium, one or more axisymmetric straight sections for reduced radial loss, a simple geometrical axis for the links and an overall positive magnetic well depth for stability. We start by describing several other attempts at linking of mirror sections, made both in the past and the present. Then a description of our helically linked mirror scheme is given. This example has three identical straight sections connected by three sections having helical geometric axes. A theoretical analysis of the magnetic field and single-particle orbits in them leads to the conclusion that most of the passing particles would be confined in the device and they would have orbits independent of pitch angle under certain conditions. Numerical results are presented, which agree well with the theoretical results as far as passing particle orbits are concerned

  18. 77 FR 37881 - 36(b)(1) Arms Sales Notification

    Science.gov (United States)

    2012-06-25

    ...) Sensitivity of Technology: 1. The AN/ALE-47 Counter-Measures Dispensing System (CMDS) is an integrated, threat... internally mounted and may be operated as a stand-alone system or may be integrated with other on-board EW and avionics systems. The AN/ALE-47 uses threat data received over the aircraft interfaces to assess...

  19. The Intensity of Human Body Odors and the MHC: Should We Expect a Link?

    Directory of Open Access Journals (Sweden)

    Claus Wedekind

    2006-01-01

    Full Text Available It is now well established that genes within the major histocompatibility complex (MHC somehow affect the production of body odors in several vertebrates, including humans. Here we discuss whether variation in the intensity of body odors may be influenced by the MHC. In order to examine this question, we have to control for MHC-linked odor perception on the smeller's side. Such a control is necessary because the perception of pleasantness and intensity seem to be confounded, and the causalities are still unsolved. It has previously been found that intense odors are scored as less pleasant if the signaler and the receiver are of MHC-dissimilar type, but not if they are of MHC similar type. We argue, and first data suggest, that an effect of the degree of MHC-heterozygosity and odor intensity is likely (MHC-homozygotes may normally smell more intense, while there is currently no strong argument for other possible links between the MHC and body odor intensity.

  20. Splitting, linking, knotting, and solitonic escape of topological defects in nematic drops with handles.

    Science.gov (United States)

    Tasinkevych, Mykola; Campbell, Michael G; Smalyukh, Ivan I

    2014-11-18

    Topologically nontrivial field excitations, including solitonic, linked, and knotted structures, play important roles in physical systems ranging from classical fluids and liquid crystals, to electromagnetism, classic, and quantum field theories. These excitations can appear spontaneously during symmetry-breaking phase transitions. For example, in cosmological theories, cosmic strings may have formed knotted configurations influencing the Early Universe development, whereas in liquid crystals transient tangled defect lines were observed during isotropic-nematic transitions, eventually relaxing to defect-free states. Knotted and solitonic fields and defects were also obtained using optical manipulation, complex-shaped colloids, and frustrated cholesterics. Here we use confinement of nematic liquid crystal by closed surfaces with varied genus and perpendicular boundary conditions for a robust control of appearance and stability of such field excitations. Theoretical modeling and experiments reveal structure of defect lines as a function of the surface topology and material and geometric parameters, establishing a robust means of controlling solitonic, knotted, linked, and other field excitations.