WorldWideScience

Sample records for linearity position sensitivity

  1. Linear position sensitive neutron detector using fiber optic encoded scintillators

    International Nuclear Information System (INIS)

    Davidson, P.L.; Wroe, H.

    1983-01-01

    A linear position sensitive slow neutron detector with 3 mm resolution is described. It uses the fiber optic coding principle in which the resolution elements are separate pieces of lithium loaded glass scintillator each coupled by means of flexible polymer optical fibers to a unique combination of 3 photo multipliers (PM's) out of a bank of 12. A decoder circuit repsponds to a triple coincidence between PM outputs and generates a 12 bit work which identifies the scintillator element which stopped the incident neutron. Some details of the construction and decoding electronics are given together with test results obtained using a laboratory isotope neutron source and a monochomated, collimated neutron beam from a reactor. The count rate in the absence of neutron sources is 2 to 3 c min - 1 per element; the element to element variation in response to a uniform flux is a few percent for 95% of the elements; the resolution as measured by a 1 mm wide prode neutron beam is 3 mm; the relative long term stability is about 0.1% over 3 days and the detection efficiency measured by comparison with an end windowed, high pressure gas counter is about 65% at a neutron wavelength of 0.9A 0

  2. Analytical expression for position sensitivity of linear response beam position monitor having inter-electrode cross talk

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Mukesh, E-mail: mukeshk@rrcat.gov.in [Beam Diagnostics Section, Indus Operations, Beam Dynamics & Diagnostics Division, Raja Ramanna Centre for Advanced Technology, Indore, 452013 MP (India); Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400 094 (India); Ojha, A.; Garg, A.D.; Puntambekar, T.A. [Beam Diagnostics Section, Indus Operations, Beam Dynamics & Diagnostics Division, Raja Ramanna Centre for Advanced Technology, Indore, 452013 MP (India); Senecha, V.K. [Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400 094 (India); Ion Source Lab., Proton Linac & Superconducting Cavities Division, Raja Ramanna Centre for Advanced Technology, Indore, 452013 MP (India)

    2017-02-01

    According to the quasi electrostatic model of linear response capacitive beam position monitor (BPM), the position sensitivity of the device depends only on the aperture of the device and it is independent of processing frequency and load impedance. In practice, however, due to the inter-electrode capacitive coupling (cross talk), the actual position sensitivity of the device decreases with increasing frequency and load impedance. We have taken into account the inter-electrode capacitance to derive and propose a new analytical expression for the position sensitivity as a function of frequency and load impedance. The sensitivity of a linear response shoe-box type BPM has been obtained through simulation using CST Studio Suite to verify and confirm the validity of the new analytical equation. Good agreement between the simulation results and the new analytical expression suggest that this method can be exploited for proper designing of BPM.

  3. Design and performance of vacuum capable detector electronics for linear position sensitive neutron detectors

    International Nuclear Information System (INIS)

    Riedel, R.A.; Cooper, R.G.; Funk, L.L.; Clonts, L.G.

    2012-01-01

    We describe the design and performance of electronics for linear position sensitive neutron detectors. The eight tube assembly requires 10 W of power and can be controlled via digital communication links. The electronics can be used without modification in vacuum. Using a transimpedance amplifier and gated integration, we achieve a highly linear system with coefficient of determinations of 0.9999 or better. Typical resolution is one percent of tube length.

  4. Design and performance of vacuum capable detector electronics for linear position sensitive neutron detectors

    Energy Technology Data Exchange (ETDEWEB)

    Riedel, R.A., E-mail: riedelra@ornl.gov [Oak Ridge National Laboratories, Oak Ridge, TN 37830 (United States); Cooper, R.G.; Funk, L.L.; Clonts, L.G. [Oak Ridge National Laboratories, Oak Ridge, TN 37830 (United States)

    2012-02-01

    We describe the design and performance of electronics for linear position sensitive neutron detectors. The eight tube assembly requires 10 W of power and can be controlled via digital communication links. The electronics can be used without modification in vacuum. Using a transimpedance amplifier and gated integration, we achieve a highly linear system with coefficient of determinations of 0.9999 or better. Typical resolution is one percent of tube length.

  5. Experimental dead time corrections for a linear position-sensitive proportional counter

    International Nuclear Information System (INIS)

    Yelon, W.B.; Tompson, C.W.; Mildner, D.F.R.; Berliner, R.; Missouri Univ., Columbia

    1984-01-01

    Two simple counters included in the charge-digitization circuitry of a position-sensitive proportional counter using the charge division method for position encoding have enabled us to determine the dead time losses for the system. An interesting positional dependence of the dead time tau is observed, which agrees with a simple model. The system enables us to correct the experimental data for dead time and to be indifferent to the relatively slow analog-to-digital converters used in the system. (orig.)

  6. Data acquisition system for linear position sensitive detector based neutron diffractometer

    International Nuclear Information System (INIS)

    Pande, S.S.; Borkar, S.P.; Behere, A.; Prafulla, S.; Srivastava, V.D.; Mukhopadhyaya, P.K.; Ghodgaonkar, M.D.; Kataria, S.K.

    2003-03-01

    This data acquisition system is developed to serve the requirements of various linear 1PSD based neutron diffractometers. A neutron diffractometer uses a neutron beam as a probe to study the crystallographic properties of materials. Presently two multi-PSD and two single-PSD diffractometers are commissioned and a few more are being installed in Dhruva. This data acquisition system is installed at each of these - diffractometers. Different requirements of individual diffractometers were studied and reconciled to design a single data acquisition system, which can be easily configured or customized for individual setups. The charge division in a linear PSD is converted to a position output with the help of an RDC (Ratio ADC). The ftont-end electronics, which consist of preamplifiers and shaping amplifiers, provide an interface between a PSD and an RDC. A PC add-on card is designed around a Transputer. It can interface 16 RDCs, a few motor controls and on/off controls. Data acquisition and other controls are implemented in the Transputer program. A front-end Windows98 application merges the raw data of different RDCs to obtain the equiangular data. Through software the data acquisition system can be configured for diffetent diffractometers. Commercially available hardware is also integrated as,a part of the data acquisition system in some of the setups. The data acquisition system is working reliably as a part of two single PSD and two multi-PSD diffractometers. It can handle data rates upto 15 K/Sec without any loss of counts. It has played a significant role in providing improved throughput and utilization ofvarious diffractometers. The'data acquisition system and its different applications are presented in this report. (author)

  7. Successful use of a linear position-sensitive neutron detector in solid state physics and materials science

    International Nuclear Information System (INIS)

    Schefer, J.; Fischer, P.; Heer, H.; Isacson, A.; Koch, M.; Thut, R.

    1991-01-01

    The double axis multicounter diffractometer (DMC) installed at the 10 MW reactor SAPHIR (PSI) has been designed as a good flux-good resolution (presently Δd/d≥4x10 -3 ) neutron poder diffractometer. The detector bank is based on a commercial position-sensitive linear BF 3 detector which may be automatically and precisely positioned on air cushions on inexpensive floors. This detector type has an 80deg angular opening, not allowing any standard collimation in front of the detector. We therefore developed an oscillating collimator system allowing easy use of the instrument even with sample environments such as a dilution cryostat. (orig.)

  8. Stanford Linear Collider magnet positioning

    International Nuclear Information System (INIS)

    Wand, B.T.

    1991-08-01

    For the installation of the Stanford Linear Collider (SLC) the positioning and alignment of the beam line components was performed in several individual steps. In the following the general procedures for each step are outlined. The calculation of ideal coordinates for the magnets in the entire SLC will be discussed in detail. Special emphasis was given to the mathematical algorithms and geometry used in the programs to calculate these ideal positions. 35 refs., 21 figs

  9. Linear positivity and virtual probability

    International Nuclear Information System (INIS)

    Hartle, James B.

    2004-01-01

    We investigate the quantum theory of closed systems based on the linear positivity decoherence condition of Goldstein and Page. The objective of any quantum theory of a closed system, most generally the universe, is the prediction of probabilities for the individual members of sets of alternative coarse-grained histories of the system. Quantum interference between members of a set of alternative histories is an obstacle to assigning probabilities that are consistent with the rules of probability theory. A quantum theory of closed systems therefore requires two elements: (1) a condition specifying which sets of histories may be assigned probabilities and (2) a rule for those probabilities. The linear positivity condition of Goldstein and Page is the weakest of the general conditions proposed so far. Its general properties relating to exact probability sum rules, time neutrality, and conservation laws are explored. Its inconsistency with the usual notion of independent subsystems in quantum mechanics is reviewed. Its relation to the stronger condition of medium decoherence necessary for classicality is discussed. The linear positivity of histories in a number of simple model systems is investigated with the aim of exhibiting linearly positive sets of histories that are not decoherent. The utility of extending the notion of probability to include values outside the range of 0-1 is described. Alternatives with such virtual probabilities cannot be measured or recorded, but can be used in the intermediate steps of calculations of real probabilities. Extended probabilities give a simple and general way of formulating quantum theory. The various decoherence conditions are compared in terms of their utility for characterizing classicality and the role they might play in further generalizations of quantum mechanics

  10. Positive Quasi Linear Operator Formulation

    International Nuclear Information System (INIS)

    Berry, L.A.; Jaeger, E.F.

    2005-01-01

    Expressions for the RF quasi-linear operator are biquadratic sums over the Fourier modes (or FLR equivalent) that describe the RF electric field with a kernel that is a function of the two wave vectors, k-vector L and k-vector R , in the sum. As a result of either an implicit or explicit average over field lines or flux surfaces, this kernel only depends on one parallel wave vector, conventionally k R -vector. When k-vector is an independent component of the representation for E, the sums are demonstrably positive. However, except for closed field line systems, k-vector is dependent on the local direction of the equilibrium magnetic field, and, empirically, the absorbed energy and quasi-linear diffusion coefficients are observed to have negative features. We have formally introduced an independent k-vector sum by Fourier transforming the RF electric field (assuming straight field lines) using a field-line-length coordinate. The resulting expression is positive. We have modeled this approach by calculating the quasi linear operator for 'modes' with fixed k-vector. We form these modes by discretizing k-vector and then assigning all of the Fourier components with k-vectorthat fall within a given k-vector bin to that k-vector mode. Results will be shown as a function of the number of bins. Future work will involve implementing the expressions derived from the Fourier transform and evaluating the dependence on field line length

  11. An apparatus for high speed measurements of small-angle x-ray scattering profiles with a linear position sensitive detector

    International Nuclear Information System (INIS)

    Hashimoto, Takeji; Suehiro, Shoji; Shibayama, Mitsuhiro; Saijo, Kenji; Kawai, Hiromichi

    1981-01-01

    An apparatus for high speed measurements of small-angle X-ray scattering (SAXS) is described. This apparatus utilizes a 12 kW rotating anode X-ray generator, a linear position sensitive proportional counter (multicathode delay line PSPC), and a two-parameter multichannel pulse height analyzer (MCA) with 12 kwords (16 bits/word) memory area available for SAXA intensity data as a function of position (scattering angles) and time slice. The two-parameter MCA is constructed within a microcomputer system, by utilizing its R/W memory for data storage, and the memory incrementing and real-time CRT display is implemented by using two direct memory access (DMA) controllers. The cycle time of the access is about 10 μs. The measuring time for SAXS profiles with this apparatus can be shortened approximately by three orders of magnitude in comparison with the measuring time with SAXS apparatuses utilizing a conventional step-scanning goniometer and a conventional X-ray tube, thus permitting time-resolved analyses of SAXS profiles. Some applications of the apparatus to dynamic SAXS measurements are presented for polymeric systems, the preliminary results of which seem to indicate the possibility of obtaining a new class of data on dynamics in structural transformation, deformation, formation and annihilation in the scale of a few tens to several hundred Angstroms. (author)

  12. Linear quadratic optimization for positive LTI system

    Science.gov (United States)

    Muhafzan, Yenti, Syafrida Wirma; Zulakmal

    2017-05-01

    Nowaday the linear quadratic optimization subject to positive linear time invariant (LTI) system constitute an interesting study considering it can become a mathematical model of variety of real problem whose variables have to nonnegative and trajectories generated by these variables must be nonnegative. In this paper we propose a method to generate an optimal control of linear quadratic optimization subject to positive linear time invariant (LTI) system. A sufficient condition that guarantee the existence of such optimal control is discussed.

  13. Position sensitive x-ray detector

    International Nuclear Information System (INIS)

    Macchione, E.L.A.

    1990-01-01

    A multi ware position sensitive gas counter for X-ray detection was developed in our laboratory, making use of commercial delay-lines for position sensing. Six delay-line chips (50 ns delay each, 40 Mhz cut-off frequency) cover a total sensitive length of 150 mm leading to a delay-risetime ratio that allows for a high-resolution position detection. Tests using the 5,9 keV X-ray line from a 55 Fe source and integral linearity better than 0,1% and a maximal differential linearity of ±4,0% were obtained operating the detector with an Ar-C H 4 (90%-10%) gas mixture at 700 torr. Similar tests were performed, using the 8,04 keV line from a Cu x-ray tube. A total resolution of 330 μm, and the same integral and differential linearities were obtained. (author)

  14. Gas position sensitive x-ray detectors

    International Nuclear Information System (INIS)

    Barbosa, A.F.

    1994-12-01

    The construction of gas x-ray detectors used to count and localize x-ray photons in one and two dimensions is reported. The principles of operation of the detectors are described, as well as the electronic modules comprised in the data acquisition system. Results obtained with detectors built at CBPF are shown, illustrating the performance of the Linear Position Sensitive Detectors. (author). 6 refs, 14 figs

  15. a Continuous-Time Positive Linear System

    Directory of Open Access Journals (Sweden)

    Kyungsup Kim

    2013-01-01

    Full Text Available This paper discusses a computational method to construct positive realizations with sparse matrices for continuous-time positive linear systems with multiple complex poles. To construct a positive realization of a continuous-time system, we use a Markov sequence similar to the impulse response sequence that is used in the discrete-time case. The existence of the proposed positive realization can be analyzed with the concept of a polyhedral convex cone. We provide a constructive algorithm to compute positive realizations with sparse matrices of some positive systems under certain conditions. A sufficient condition for the existence of a positive realization, under which the proposed constructive algorithm works well, is analyzed.

  16. Submicron position-sensitive detector

    Energy Technology Data Exchange (ETDEWEB)

    Pugatch, V M; Rosenfeld, A B; Litovchenko, P G; Barabash, L I; Nemets, O F; Pavlenko, Yu N; Vasiliev, Yu O [Ukrainian Academy of Sciences, Kiev (Ukraine). Inst. for Nuclear Research

    1992-08-01

    A method has been developed to measure precisely the coordinates of charged particles incident between adjacent strips of a strip detector. The position sensitivity of an inter-strip gap has been studied by means of a pulsed laser beam and irradiation by [alpha]-particles of a [sup 226]Ra-source. The capacitive division of charge generated by the incident particle depends on the position of its track. Its coordinates were determined by two-dimensional amplitude analysis of the charges collected by neighbouring strips. This method of coordinate determination applied to studies of spatial and energy distributions of electromagnetic as well as charged particle beams (including radioactive ion beams) of low intensity could provide the highest level of the precision limited by the track dimensions of charged particles, i.e. percents of a micrometer. (orig.).

  17. Position-sensitive superconductor detectors

    International Nuclear Information System (INIS)

    Kurakado, M.; Taniguchi, K.

    2016-01-01

    Superconducting tunnel junction (STJ) detectors and superconducting transition- edge sensors (TESs) are representative superconductor detectors having energy resolutions much higher than those of semiconductor detectors. STJ detectors are thin, thereby making it suitable for detecting low-energy X rays. The signals of STJ detectors are more than 100 times faster than those of TESs. By contrast, TESs are microcalorimeters that measure the radiation energy from the change in the temperature. Therefore, signals are slow and their time constants are typically several hundreds of μs. However, TESs possess excellent energy resolutions. For example, TESs have a resolution of 1.6 eV for 5.9-keV X rays. An array of STJs or TESs can be used as a pixel detector. Superconducting series-junction detectors (SSJDs) comprise multiple STJs and a single-crystal substrate that acts as a radiation absorber. SSJDs are also position sensitive, and their energy resolutions are higher than those of semiconductor detectors. In this paper, we give an overview of position-sensitive superconductor detectors.

  18. Position-sensitive proportional counter

    International Nuclear Information System (INIS)

    Kopp, M.K.

    1980-01-01

    A position-sensitive proportional counter circuit uses a conventional (low-resistance, metal-wire anode) counter for spatial resolution of an ionizing event along the anode, which functions as an RC line. A pair of preamplifiers at the anode ends act as stabilized active-capacitance loads, each comprising a series-feedback, low-noise amplifier and a unity-gain, shunt-feedback amplifier whose output is connected through a feedback capacitor to the series-feedback amplifier input. The stabilized capacitance loading of the anode allows distributed RC-line position encoding and subsequent time difference decoding by sensing the difference in rise times of pulses at the anode ends where the difference is primarily in response to the distributed capacitance along the anode. This allows the use of lower resistance wire anodes for spatial radiation detection which simplifies the counter construction of handling of the anodes, and stabilizes the anode resistivity at high count rates (>10 6 counts/sec). (author)

  19. Positivity of linear maps under tensor powers

    Energy Technology Data Exchange (ETDEWEB)

    Müller-Hermes, Alexander, E-mail: muellerh@ma.tum.de; Wolf, Michael M., E-mail: m.wolf@tum.de [Zentrum Mathematik, Technische Universität München, 85748 Garching (Germany); Reeb, David, E-mail: reeb.qit@gmail.com [Zentrum Mathematik, Technische Universität München, 85748 Garching (Germany); Institute for Theoretical Physics, Leibniz Universität Hannover, 30167 Hannover (Germany)

    2016-01-15

    We investigate linear maps between matrix algebras that remain positive under tensor powers, i.e., under tensoring with n copies of themselves. Completely positive and completely co-positive maps are trivial examples of this kind. We show that for every n ∈ ℕ, there exist non-trivial maps with this property and that for two-dimensional Hilbert spaces there is no non-trivial map for which this holds for all n. For higher dimensions, we reduce the existence question of such non-trivial “tensor-stable positive maps” to a one-parameter family of maps and show that an affirmative answer would imply the existence of non-positive partial transpose bound entanglement. As an application, we show that any tensor-stable positive map that is not completely positive yields an upper bound on the quantum channel capacity, which for the transposition map gives the well-known cb-norm bound. We, furthermore, show that the latter is an upper bound even for the local operations and classical communications-assisted quantum capacity, and that moreover it is a strong converse rate for this task.

  20. Positivity of linear maps under tensor powers

    International Nuclear Information System (INIS)

    Müller-Hermes, Alexander; Wolf, Michael M.; Reeb, David

    2016-01-01

    We investigate linear maps between matrix algebras that remain positive under tensor powers, i.e., under tensoring with n copies of themselves. Completely positive and completely co-positive maps are trivial examples of this kind. We show that for every n ∈ ℕ, there exist non-trivial maps with this property and that for two-dimensional Hilbert spaces there is no non-trivial map for which this holds for all n. For higher dimensions, we reduce the existence question of such non-trivial “tensor-stable positive maps” to a one-parameter family of maps and show that an affirmative answer would imply the existence of non-positive partial transpose bound entanglement. As an application, we show that any tensor-stable positive map that is not completely positive yields an upper bound on the quantum channel capacity, which for the transposition map gives the well-known cb-norm bound. We, furthermore, show that the latter is an upper bound even for the local operations and classical communications-assisted quantum capacity, and that moreover it is a strong converse rate for this task

  1. Position sensitive detector used to detect beam profile

    International Nuclear Information System (INIS)

    Zhao Xiaoyan; Zhao Zhizheng; Zu Kailing; Zheng Jianhua; Wang Yifang

    2003-01-01

    In order to study the detecting system of the residual-gas beam profile, we introduce the principle and construction of the Position Sensitive Detector (PSD). The performance of PSD is tested. Position resolution, position linearity, detection efficiency and background are obtained

  2. Position-sensitive radiation detector

    International Nuclear Information System (INIS)

    Mathieson, E.; Smith, G.C.; Gilvin, P.J.

    1981-01-01

    Apparatus for sensing the position of radiation received has a plurality of receptors spaced in at least one line on which the position is to be determined, their outputs being associated to form at least two groups, the density of the receptors in each group varying along the line. The receptors may comprise cathode arrays of a multiwire proportional counter, with an anode array between, measuring along lines in directions x and y respectively. The density of the wires in the two groups, decreases in opposite directions. A circuit determines the ratio of the output of one group to the sum of the group outputs. In another embodiment a scintillator is viewed by a plurality of light guides, the ends of which adjacent to the scintillator form the receptors, the four groups of which each terminate on a photomultiplier. (author)

  3. Large area two dimensional position sensitive detectors

    International Nuclear Information System (INIS)

    Sann, H.; Olmi, A.; Lynen, U.; Stelzer, H.; Gobbi, A.; Bock, R.

    1979-02-01

    After an introduction, a position-sensitive ionization chamber, a parallel-plate detector, and a multiwire position-sensitive chamber are described. Then the data acquisition and analysis methods are considered. Furthermore, the experimental methods for a multi-parameter experiment are described. Finally, the measurement of gamma-ray and neutron multiplicities and sequential fission is considered, and the results are presented. (HSI) [de

  4. A position sensitive parallel plate avalanche counter

    International Nuclear Information System (INIS)

    Lombardi, M.; Tan Jilian; Potenza, R.; D'amico, V.

    1986-01-01

    A position sensitive parallel plate avalanche counter with a distributed constant delay-line-cathode (PSAC) is described. The strips formed on the printed board were served as the cathode and the delay line for readout of signals. The detector (PSAC) was operated in isobutane gas at the pressure range from 10 to 20 torr. The position resolution is better than 1 mm and the time resolution is about 350 ps, for 252 Cf fission-spectrum source

  5. Signal processors for position-sensitive detectors

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Ken-ichi [Hosei Univ., Koganei, Tokyo (Japan). Coll. of Engineering

    1996-07-01

    Position-sensitive detectors (PSD) are widely used in following various fields: condensed matter studies, material engineering, medical radiology particle physics, astrophysics and industrial applications. X-ray diffraction analysis is one of the field where PSDs are the most important instruments. In this field, many types of PSAs are employed: position-sensitive proportional counters (PSPC), multi-wire proportional chambers (MWPC), imaging plates, image intensifiers combined CCD cameras and semiconductor array devices. Two readout systems used for PSDs, where one is a charge-division type with high stability and the other is an encoder with multiple delay, line readout circuits useful for fast counting, were reported in this paper. The multiple delay line encoding system can be applicable to high counting rate 1D and 2D gas proportional detectors. (G.K.)

  6. Two-dimensional position sensitive neutron detector

    Indian Academy of Sciences (India)

    The detector is a 3He + Kr filled multiwire proportional counter with charge division position readout and has a sensitive area of 345 mm × 345 mm, pixel size 5 mm × 5 mm, active depth 25 mm and is designed for efficiency of 70% for 4 Å neutrons. The detector is tested with 0.5 bar 3He + 1.5 bar krypton gas mixture in active ...

  7. Position-sensitive X-ray detectors

    International Nuclear Information System (INIS)

    Hendrix, J.

    1982-01-01

    In this review of the application of different types of position sensitive detectors to synchrotron radiation, discussion of the proportional counters based on the gas amplification principle forms a major part. Other topics reviewed are detector requirements, multiwire proportional chamber system, drift chamber type detectors, TV detectors, and recent developments, such as that based on a micro-channel plate as the amplifying element, and charge-coupled devices. (U.K.)

  8. Linear Parametric Sensitivity Analysis of the Constraint Coefficient Matrix in Linear Programs

    OpenAIRE

    Zuidwijk, Rob

    2005-01-01

    textabstractSensitivity analysis is used to quantify the impact of changes in the initial data of linear programs on the optimal value. In particular, parametric sensitivity analysis involves a perturbation analysis in which the effects of small changes of some or all of the initial data on an optimal solution are investigated, and the optimal solution is studied on a so-called critical range of the initial data, in which certain properties such as the optimal basis in linear programming are ...

  9. POWRS: position-sensitive motif discovery.

    Directory of Open Access Journals (Sweden)

    Ian W Davis

    Full Text Available Transcription factors and the short, often degenerate DNA sequences they recognize are central regulators of gene expression, but their regulatory code is challenging to dissect experimentally. Thus, computational approaches have long been used to identify putative regulatory elements from the patterns in promoter sequences. Here we present a new algorithm "POWRS" (POsition-sensitive WoRd Set for identifying regulatory sequence motifs, specifically developed to address two common shortcomings of existing algorithms. First, POWRS uses the position-specific enrichment of regulatory elements near transcription start sites to significantly increase sensitivity, while providing new information about the preferred localization of those elements. Second, POWRS forgoes position weight matrices for a discrete motif representation that appears more resistant to over-generalization. We apply this algorithm to discover sequences related to constitutive, high-level gene expression in the model plant Arabidopsis thaliana, and then experimentally validate the importance of those elements by systematically mutating two endogenous promoters and measuring the effect on gene expression levels. This provides a foundation for future efforts to rationally engineer gene expression in plants, a problem of great importance in developing biotech crop varieties.BSD-licensed Python code at http://grassrootsbio.com/papers/powrs/.

  10. Linear Parametric Sensitivity Analysis of the Constraint Coefficient Matrix in Linear Programs

    NARCIS (Netherlands)

    R.A. Zuidwijk (Rob)

    2005-01-01

    textabstractSensitivity analysis is used to quantify the impact of changes in the initial data of linear programs on the optimal value. In particular, parametric sensitivity analysis involves a perturbation analysis in which the effects of small changes of some or all of the initial data on an

  11. Linear Array Ultrasonic Transducers: Sensitivity and Resolution Study

    International Nuclear Information System (INIS)

    Kramb, V.A.

    2005-01-01

    The University of Dayton Research Institute (UDRI) under contract by the US Air Force has designed and integrated a fully automated inspection system for the inspection of turbine engines that incorporates linear phased array ultrasonic transducers. Phased array transducers have been successfully implemented into weld and turbine blade root inspections where the defect types are well known and characterized. Embedded defects in aerospace turbine engine components are less well defined, however. In order to determine the applicability of linear arrays to aerospace inspections the sensitivity of array transducers to embedded defects in engine materials must be characterized. In addition, the implementation of array transducers into legacy inspection procedures must take into account any differences in sensitivity between the array transducer and that of the single element transducer currently used. This paper discusses preliminary results in a study that compares the sensitivity of linear array and conventional single element transducers to synthetic hard alpha defects in a titanium alloy

  12. Position-sensitive X-ray detectors

    International Nuclear Information System (INIS)

    Hendrix, J.

    1982-01-01

    An overview is given of the different types of position-sensitive X-ray detectors used in kinetic studies of biological molecule state changes using X-ray diffraction with synchrotron radiation as a probe. The detector requirements and principles of operation of proportional counters are outlined. Multiwire proportional chamber systems and their readout techniques are described. Other detectors discussed include a drift chamber type detector, microchannel plates, charge-couple devices and, for high count rates, an integrating TV-detector. (U.K.)

  13. Entanglement witnesses arising from exposed positive linear maps

    OpenAIRE

    Ha, Kil-Chan; Kye, Seung-Hyeok

    2011-01-01

    We consider entanglement witnesses arising from positive linear maps which generate exposed extremal rays. We show that every entanglement can be detected by one of these witnesses, and this witness detects a unique set of entanglement among those. Therefore, they provide a minimal set of witnesses to detect all entanglement in a sense. Furthermore, if those maps are indecomposable then they detect large classes of entanglement with positive partial transposes which have nonempty relative int...

  14. Position-sensitive transition-edge sensors

    International Nuclear Information System (INIS)

    Iyomoto, N.; Bandler, S.R.; Brekosky, R.P.; Chervenak, J.A.; Figueroa-Feliciano, E.; Finkbeiner, F.M.; Kelley, R.L.; Kilbourne, C.A.; Lindeman, M.A.; Murphy, K.; Porter, F.S.; Saab, T.; Sadleir, J.E.; Talley, D.J.

    2006-01-01

    We report the latest results from our development of Position-Sensitive Transition-edge sensors (PoSTs), which are one-dimensional imaging spectrometers. In PoSTs with segmented Au absorbers, we obtained 8eV energy resolution on K Kα lines, which is consistent to the baseline energy resolution and the design values, on all of the nine pixels, by choosing the best combination of the thermal conductance in absorbers and in links that connects the absorbers. The pulse decay time of 193μs is fast enough for our purpose. In a PoST with a continuous Bi/Cu absorber, by dividing the events into 63 effective pixels, we obtained energy resolutions of 16eV at the center 'pixel', which is comparable to the baseline energy resolution, and 33eV at the outer 'pixel'. The degradation of the energy resolution in the outer 'pixel' is due to position dependence, which we can cancel out by dividing the events into smaller 'pixels' when we have sufficient X-ray events

  15. Position sensor for linear synchronous motors employing halbach arrays

    Science.gov (United States)

    Post, Richard Freeman

    2014-12-23

    A position sensor suitable for use in linear synchronous motor (LSM) drive systems employing Halbach arrays to create their magnetic fields is described. The system has several advantages over previously employed ones, especially in its simplicity and its freedom from being affected by weather conditions, accumulated dirt, or electrical interference from the LSM system itself.

  16. Ideal Convergence of k-Positive Linear Operators

    Directory of Open Access Journals (Sweden)

    Akif Gadjiev

    2012-01-01

    Full Text Available We study some ideal convergence results of k-positive linear operators defined on an appropriate subspace of the space of all analytic functions on a bounded simply connected domain in the complex plane. We also show that our approximation results with respect to ideal convergence are more general than the classical ones.

  17. An X-ray gas position sensitive detector: construction and characterization

    International Nuclear Information System (INIS)

    Barbosa, A.F.; Gabriel, A.; Gabriel, A.; Craievich, A.

    1988-01-01

    A linear x-ray gas position sensitive detector with delay line readout has been constructed. The detector is described, characterized and used for detecting x-ray diffraction patterns from polycrystals. (author) [pt

  18. Two dimension position sensitive multi-plate PPAC

    International Nuclear Information System (INIS)

    Mao Ruishi; Guo Zhongyan; Xiao Guoqing; Zhan Wenlong; Xu Hushan; Hu Zhengguo; Wang Meng; Sun Zhiyu; Chen Zhiqiang; Chen Lixin; Li Chen; Bai Jie; Zhang Jinxia; Li Cunfan

    2003-01-01

    A two-dimensional positional sensitive multi-plate PPAC with resistance chain readout has been developed for Radioactive Ion Beam Line in Lanzhou (RIBLL). The PPAC has an active area of 100 mm x 100 mm. It consists of an anode plane, a x wire plane, a y wire plane and two cathode planes. The gaps between anode and wire planes are 3 mm. And the gaps between cathodes and wire planes also are 3 mm. When filled with iso-butane at a pressure of 6.5 mb, the 0.58 mm (FWHM) position resolution and >99.2% detection efficiencies and <±50 μm linearity of the PPAC was estimated for 3 components α source

  19. Linear micromechanical stepping drive for pinhole array positioning

    International Nuclear Information System (INIS)

    Endrödy, Csaba; Mehner, Hannes; Hoffmann, Martin; Grewe, Adrian

    2015-01-01

    A compact linear micromechanical stepping drive for positioning a 7 × 5.5 mm 2 optical pinhole array is presented. The system features a step size of 13.2 µm and a full displacement range of 200 µm. The electrostatic inch-worm stepping mechanism shows a compact design capable of positioning a payload 50% of its own weight. The stepping drive movement, step sizes and position accuracy are characterized. The actuated pinhole array is integrated in a confocal chromatic hyperspectral imaging system, where coverage of the object plane, and therefore the useful picture data, can be multiplied by 14 in contrast to a non-actuated array. (paper)

  20. Linear regression and sensitivity analysis in nuclear reactor design

    International Nuclear Information System (INIS)

    Kumar, Akansha; Tsvetkov, Pavel V.; McClarren, Ryan G.

    2015-01-01

    Highlights: • Presented a benchmark for the applicability of linear regression to complex systems. • Applied linear regression to a nuclear reactor power system. • Performed neutronics, thermal–hydraulics, and energy conversion using Brayton’s cycle for the design of a GCFBR. • Performed detailed sensitivity analysis to a set of parameters in a nuclear reactor power system. • Modeled and developed reactor design using MCNP, regression using R, and thermal–hydraulics in Java. - Abstract: The paper presents a general strategy applicable for sensitivity analysis (SA), and uncertainity quantification analysis (UA) of parameters related to a nuclear reactor design. This work also validates the use of linear regression (LR) for predictive analysis in a nuclear reactor design. The analysis helps to determine the parameters on which a LR model can be fit for predictive analysis. For those parameters, a regression surface is created based on trial data and predictions are made using this surface. A general strategy of SA to determine and identify the influential parameters those affect the operation of the reactor is mentioned. Identification of design parameters and validation of linearity assumption for the application of LR of reactor design based on a set of tests is performed. The testing methods used to determine the behavior of the parameters can be used as a general strategy for UA, and SA of nuclear reactor models, and thermal hydraulics calculations. A design of a gas cooled fast breeder reactor (GCFBR), with thermal–hydraulics, and energy transfer has been used for the demonstration of this method. MCNP6 is used to simulate the GCFBR design, and perform the necessary criticality calculations. Java is used to build and run input samples, and to extract data from the output files of MCNP6, and R is used to perform regression analysis and other multivariate variance, and analysis of the collinearity of data

  1. 32 CFR 154.13 - Sensitive positions.

    Science.gov (United States)

    2010-07-01

    ...) Critical-sensitive. (A) Access to Top Secret information. (B) Development or approval of plans, policies... report required in subpart K. (e) Billet control system for Top Secret. (1) To standardize and control the issuance of Top Secret clearances within the Department of Defense, a specific designated billet...

  2. A linear actuator for precision positioning of dual objects

    International Nuclear Information System (INIS)

    Peng, Yuxin; Cao, Jie; Guo, Zhao; Yu, Haoyong

    2015-01-01

    In this paper, a linear actuator for precision positioning of dual objects is proposed based on a double friction drive principle using a single piezoelectric element (PZT). The linear actuator consists of an electromagnet and a permanent magnet, which are connected by the PZT. The electromagnet serves as an object 1, and another object (object 2) is attached on the permanent magnet by the magnetic force. For positioning the dual objects independently, two different friction drive modes can be alternated by an on–off control of the electromagnet. When the electromagnet releases from the guide way, it can be driven by impact friction force generated by the PZT. Otherwise, when the electromagnet clamps on the guide way and remains stationary, the object 2 can be driven based on the principle of smooth impact friction drive. A prototype was designed and constructed and experiments were carried out to test the basic performance of the actuator. It has been verified that with a compact size of 31 mm (L) × 12 mm (W) × 8 mm (H), the two objects can achieve long strokes on the order of several millimeters and high resolutions of several tens of nanometers. Since the proposed actuator allows independent movement of two objects by a single PZT, the actuator has the potential to be constructed compactly. (paper)

  3. Position sensitive detector for X-ray photons

    International Nuclear Information System (INIS)

    Barbosa, A.F.

    1988-01-01

    This work reports the theoretical basis and the details of the construction process, characterization and application of gas X-ray position sensitive detectors. The unidimensional detector consists of a gas camera (argon and CH 4 ), a metallic anode, a cathode and a delay line. Details of the construction process are given in order to allow the reproduction of the detector. It has been characterized by measuring its spatial resolution, homogeneity and linerity. The built linear detector has been used to obtain diffraction diagrams from polycrystalline silicon, C 23 H 48 paraffin and glassy carbon. These diagrams have been compared with those obtained under equivalent conditions with a conventional proportional detector by the step scanning method. It has been shown that the detector provides diffraction diagrams of equivalent quality to those obtained by the step scanning method, in appreciably lower time intervals. (author) [pt

  4. Position sensitive silicon detectors inside the Tevatron collider

    International Nuclear Information System (INIS)

    Apollinari, G.; Bedeschi, F.; Bellettini, G.; Bosi, F.; Bosisio, L.; Cervelli, F.; Del Fabbro, R.; Dell'Orso, M.; Di Virgilio, A.; Focardi, E.; Giannetti, P.; Giorgi, M.; Menzione, A.; Ristori, L.; Scribano, A.; Sestini, P.; Stefanini, A.; Tonelli, G.; Zetti, F.; Bertolucci, S.; Cordelli, M.; Curatolo, M.; Dulach, B.; Esposito, B.; Giromini, P.; Miscetti, S.; Sansoni, A.

    1986-01-01

    Four position sensitive silicon detectors have been tested inside the Tevatron beam pipe at Fermilab. The system is the prototype of the small angle silicon spectrometer designed to study primarily p-anti p elastic and diffractive cross-sections at the Collider of Fermilab (CDF). Particles in the beam halo during p-anti p storage tests were used to study the performance of the detectors. Efficiency, linearity of response and spatial resolution are shown. Measurements performed at different distances from the beam axis have shown that the detectors could be operated at 8.5 mm from the beam with low rates and no disturbance to the circulating beams. This distance corresponds to about 11 times the standard half-width of the local beam envelope. The behaviour of the detectors with the radiation dose has also been investigated. (orig.)

  5. Incomplete factorization technique for positive definite linear systems

    International Nuclear Information System (INIS)

    Manteuffel, T.A.

    1980-01-01

    This paper describes a technique for solving the large sparse symmetric linear systems that arise from the application of finite element methods. The technique combines an incomplete factorization method called the shifted incomplete Cholesky factorization with the method of generalized conjugate gradients. The shifted incomplete Cholesky factorization produces a splitting of the matrix A that is dependent upon a parameter α. It is shown that if A is positive definite, then there is some α for which this splitting is possible and that this splitting is at least as good as the Jacobi splitting. The method is shown to be more efficient on a set of test problems than either direct methods or explicit iteration schemes

  6. Reliability and Validity Assessment of a Linear Position Transducer

    Science.gov (United States)

    Garnacho-Castaño, Manuel V.; López-Lastra, Silvia; Maté-Muñoz, José L.

    2015-01-01

    The objectives of the study were to determine the validity and reliability of peak velocity (PV), average velocity (AV), peak power (PP) and average power (AP) measurements were made using a linear position transducer. Validity was assessed by comparing measurements simultaneously obtained using the Tendo Weightlifting Analyzer Systemi and T-Force Dynamic Measurement Systemr (Ergotech, Murcia, Spain) during two resistance exercises, bench press (BP) and full back squat (BS), performed by 71 trained male subjects. For the reliability study, a further 32 men completed both lifts using the Tendo Weightlifting Analyzer Systemz in two identical testing sessions one week apart (session 1 vs. session 2). Intraclass correlation coefficients (ICCs) indicating the validity of the Tendo Weightlifting Analyzer Systemi were high, with values ranging from 0.853 to 0.989. Systematic biases and random errors were low to moderate for almost all variables, being higher in the case of PP (bias ±157.56 W; error ±131.84 W). Proportional biases were identified for almost all variables. Test-retest reliability was strong with ICCs ranging from 0.922 to 0.988. Reliability results also showed minimal systematic biases and random errors, which were only significant for PP (bias -19.19 W; error ±67.57 W). Only PV recorded in the BS showed no significant proportional bias. The Tendo Weightlifting Analyzer Systemi emerged as a reliable system for measuring movement velocity and estimating power in resistance exercises. The low biases and random errors observed here (mainly AV, AP) make this device a useful tool for monitoring resistance training. Key points This study determined the validity and reliability of peak velocity, average velocity, peak power and average power measurements made using a linear position transducer The Tendo Weight-lifting Analyzer Systemi emerged as a reliable system for measuring movement velocity and power. PMID:25729300

  7. Use of position sensitive detectors in medicine

    International Nuclear Information System (INIS)

    Soussaline, F.

    1982-10-01

    Medical imagery is a field where developments in physics, engineering and instrumentation can be applied directly to human diagnosis and treatment. The need to detect ever-smaller anomalies and to measure increasingly slight variations in metabolic parameters has led to a high degree of complexity in radiographic, echographic and nuclear medicine instrumentation. The wide-spread use of digital circuits and more generally the development of data processing systems and mathematical algorithms has allowed the introduction of new techniques such as emission and transmission tomography, digitalised radiography, synchronised gamma cardiology and nuclear magnetic resonance. For reasons of brevity this article is confined to the presentation of some concepts and results in the field of computer-assisted tomography and a discussion on the main parameters of imagery systems using position detectors

  8. Correction of X-ray diffraction profiles in linear-type PSPC by position factor

    International Nuclear Information System (INIS)

    Takahashi, Toshio

    1992-01-01

    PSPC (Position Sensitive Proportional Counter) makes it possible to obtain one-dimentional diffraction profiles without mechanical scanning. In a linear-type PSPC, the obtained profiles need correcting, because the position factor influences the intensity of the diffracted X-ray beam and the counting rate at each position on PSPC. The distances from the specimen are not the same at the center and at the edge of the detector, and the intensity decreases at the edge because of radiation and absorption. The counting rate varies with the incident angle of the diffracted beam at each position on PSPC. The position factor f i at channel i of the multichannel-analyser is given by f i = cos 4 α i ·exp{-μR(1/cosα i -1)} where R is the distance between the specimen and the center of PSPC, μ is the linear absorption coefficient and α i is the incident angle of the diffracted beam at channel i. The background profiles of silica gel powder were measured with CrKα and CuKα. The parameters of the model function were fitted to the profiles by the non-linear least squares method. The agreement between these parameters and the calculated values shows that the position factor can correct the measured profiles properly. (author)

  9. The linear variable differential transformer (LVDT) position sensor for gravitational wave interferometer low-frequency controls

    Energy Technology Data Exchange (ETDEWEB)

    Tariq, Hareem E-mail: htariq@ligo.caltech.edu; Takamori, Akiteru; Vetrano, Flavio; Wang Chenyang; Bertolini, Alessandro; Calamai, Giovanni; DeSalvo, Riccardo; Gennai, Alberto; Holloway, Lee; Losurdo, Giovanni; Marka, Szabolcs; Mazzoni, Massimo; Paoletti, Federico; Passuello, Diego; Sannibale, Virginio; Stanga, Ruggero

    2002-08-21

    Low-power, ultra-high-vacuum compatible, non-contacting position sensors with nanometer resolution and centimeter dynamic range have been developed, built and tested. They have been designed at Virgo as the sensors for low-frequency modal damping of Seismic Attenuation System chains in Gravitational Wave interferometers and sub-micron absolute mirror positioning. One type of these linear variable differential transformers (LVDTs) has been designed to be also insensitive to transversal displacement thus allowing 3D movement of the sensor head while still precisely reading its position along the sensitivity axis. A second LVDT geometry has been designed to measure the displacement of the vertical seismic attenuation filters from their nominal position. Unlike the commercial LVDTs, mostly based on magnetic cores, the LVDTs described here exert no force on the measured structure.

  10. Linear electrostatic micromotors for nano- and micro-positioning

    Science.gov (United States)

    Baginsky, I. L.; Kostsov, Edvard G.

    2004-05-01

    The functioning of the linear step electrostatic film micromotors with the short controlling pulse (less then 100-200 ´s) is studied to create nano- and micro-positioners. The theoretical study of the step movement of the given mass in this time frame is carried out. The results of the experimental studies of the multipetal reciprocal micromotors created on the basis of La modified Ba0.5Sr0.5Nb2O6 ferroelectric films with 1-3 μm thickness are shown. The petals were made of beryllium bronze. It is shown that the electrostatic rolling can last less than 50 μs, and the process of separating two surfaces (the metal and the ferroelectric) can last less than 1 μs. These parameters allow one to operate the micromotor at 1-10 kHz frequency, and the propulsion force in the beginning (the first 20-100 μs) of the electrostatic rolling can be as high as 1-10 N per 1 mm2 of the rolling surface with the voltage pulse amplitude of 40-50 V. The possibility of obtaining moving plate (MP) step in the nanometer range is studied, as well as the precision of these steps during the continuous MP movement with the different clock frequencies and durations of the voltage pulses. The recommendations are given to improve the accuracy and the speed of the positioning in the nano- and micro-movement range. Possible fields of micromotor application are micromechanics, including precision micromechanics, microelectronics, microrobots, microoptics, microscanners, micropumps (e.g. in the jet printers), micro flying vehicles etc.

  11. Reliability and Validity Assessment of a Linear Position Transducer

    Directory of Open Access Journals (Sweden)

    Manuel V. Garnacho-Castaño

    2015-03-01

    Full Text Available The objectives of the study were to determine the validity and reliability of peak velocity (PV, average velocity (AV, peak power (PP and average power (AP measurements were made using a linear position transducer. Validity was assessed by comparing measurements simultaneously obtained using the Tendo Weightlifting Analyzer Systemi and T-Force Dynamic Measurement Systemr (Ergotech, Murcia, Spain during two resistance exercises, bench press (BP and full back squat (BS, performed by 71 trained male subjects. For the reliability study, a further 32 men completed both lifts using the Tendo Weightlifting Analyzer Systemz in two identical testing sessions one week apart (session 1 vs. session 2. Intraclass correlation coefficients (ICCs indicating the validity of the Tendo Weightlifting Analyzer Systemi were high, with values ranging from 0.853 to 0.989. Systematic biases and random errors were low to moderate for almost all variables, being higher in the case of PP (bias ±157.56 W; error ±131.84 W. Proportional biases were identified for almost all variables. Test-retest reliability was strong with ICCs ranging from 0.922 to 0.988. Reliability results also showed minimal systematic biases and random errors, which were only significant for PP (bias -19.19 W; error ±67.57 W. Only PV recorded in the BS showed no significant proportional bias. The Tendo Weightlifting Analyzer Systemi emerged as a reliable system for measuring movement velocity and estimating power in resistance exercises. The low biases and random errors observed here (mainly AV, AP make this device a useful tool for monitoring resistance training.

  12. A large area two-dimensional position sensitive multiwire proportional detector

    CERN Document Server

    Moura, M M D; Souza, F A; Alonso, E E; Fujii, R J; Meyknecht, A B; Added, N; Aissaoui, N; Cardenas, W H Z; Ferraretto, M D; Schnitter, U; Szanto, E M; Szanto de Toledo, A; Yamamura, M S; Carlin, N

    1999-01-01

    Large area two-dimensional position sensitive multiwire proportional detectors were developed to be used in the study of light heavy-ion nuclear reactions at the University of Sao Paulo Pelletron Laboratory. Each detector has a 20x20 cm sup 2 active area and consists of three grids (X-position, anode and Y-position) made of 25 mu m diameter gold plated tungsten wires. The position is determined through resistive divider chains. Results for position resolution, linearity and efficiency as a function of energy and position for different elements are reported.

  13. Digital position sensitive discrimination for 2-dimensional scintillation detectors

    International Nuclear Information System (INIS)

    Engels, R.; Reinartz, R.; Reinhart, P.

    1996-01-01

    The energy sensitivity of a two-dimensional scintillation gamma detector based on position sensitive photomultipliers has been minimized by a digital differential discrimination unit. Since the photomultiplier gain is position-dependent by 50%, a discrimination unit has been developed where digital upper and lower discrimination levels are set due to the position-dependent photomultiplier gain obtained from calibration measurements. Depending on the spatial resolution there can be up to 65.536 position-sensitive discriminator levels defining energy windows. By this method, narrow discriminator windows can be used for reducing the low and high energy quanta without effecting the sensitivity of the detector. The new discrimination method, its performance and test measurements with gamma rays will be described. Furthermore experimental results are presented

  14. Analytic central path, sensitivity analysis and parametric linear programming

    NARCIS (Netherlands)

    A.G. Holder; J.F. Sturm; S. Zhang (Shuzhong)

    1998-01-01

    textabstractIn this paper we consider properties of the central path and the analytic center of the optimal face in the context of parametric linear programming. We first show that if the right-hand side vector of a standard linear program is perturbed, then the analytic center of the optimal face

  15. Two-dimensional position sensitive Si(Li) detector

    International Nuclear Information System (INIS)

    Walton, J.T.; Hubbard, G.S.; Haller, E.E.; Sommer, H.A.

    1978-11-01

    Circular, large-area two-dimensional Si(Li) position sensitive detectors have been fabricated. The detectors employ a thin lithium-diffused n + resisitive layer for one contact and a boron implanted p + resistive layer for the second contact. A position resolution of the order of 100 μm is indicated

  16. A TWO-DIMENSIONAL POSITION SENSITIVE SI(LI) DETECTOR

    Energy Technology Data Exchange (ETDEWEB)

    Walton, Jack T.; Hubbard, G. Scott; Haller, Eugene E.; Sommer, Heinrich A.

    1978-11-01

    Circular, large-area two-dimensional Si(Li) position sensitive detectors have been fabricated. The detectors employ a thin lithium-diffused n{sup +} resistive layer for one contact and a boron implanted p{sup +} resistive layer for the second contact. A position resolution of the order of 100 {micro}m is indicated.

  17. Vantage sensitivity: individual differences in response to positive experiences.

    Science.gov (United States)

    Pluess, Michael; Belsky, Jay

    2013-07-01

    The notion that some people are more vulnerable to adversity as a function of inherent risk characteristics is widely embraced in most fields of psychology. This is reflected in the popularity of the diathesis-stress framework, which has received a vast amount of empirical support over the years. Much less effort has been directed toward the investigation of endogenous factors associated with variability in response to positive influences. One reason for the failure to investigate individual differences in response to positive experiences as a function of endogenous factors may be the absence of adequate theoretical frameworks. According to the differential-susceptibility hypothesis, individuals generally vary in their developmental plasticity regardless of whether they are exposed to negative or positive influences--a notion derived from evolutionary reasoning. On the basis of this now well-supported proposition, we advance herein the new concept of vantage sensitivity, reflecting variation in response to exclusively positive experiences as a function of individual endogenous characteristics. After distinguishing vantage sensitivity from theoretically related concepts of differential-susceptibility and resilience, we review some recent empirical evidence for vantage sensitivity featuring behavioral, physiological, and genetic factors as moderators of a wide range of positive experiences ranging from family environment and psychotherapy to educational intervention. Thereafter, we discuss genetic and environmental factors contributing to individual differences in vantage sensitivity, potential mechanisms underlying vantage sensitivity, and practical implications. 2013 APA, all rights reserved

  18. Scintillating fibre detectors using position-sensitive photomultipliers

    International Nuclear Information System (INIS)

    Agoritsas, V.; Bergdolt, A.M.; Bing, O.; Bravar, A.; Ditta, J.; Drevenak, R.

    1995-01-01

    Scintillating fibre technology has made substantial progress, and has demonstrated great potential for fast tracking and triggering in high luminosity experiments in Particle Physics. Some recent issues of the RD-17 project at CERN are presented for fast and precise readout of scintillating fibre arrays, as well as for upgrade of position-sensitive photomultipliers. Excellent matching of the scintillating fibre and the position-sensitive photomultiplier, in particular in time characteristics, allowed to achieve excellent detector performances, typically a spatial resolution of ∼ 125 μm with time resolution better than 1 ns and detection efficiency greater than 95%. (author)10 refs.; 25 figs.; 1 tab

  19. A setup for measurement of beam stability and position using position sensitive detector for Indus-1

    International Nuclear Information System (INIS)

    Nathwani, R.K.; Joshi, D.K.; Tyagi, Y.; Soni, R.S.; Puntambekar, T.A.; Pithawa, C.K.

    2009-01-01

    The 450 MeV electron synchrotron radiation source Indus-1 is operational at RRCAT. A set-up has been developed to measure the relative transverse positional stability of the electron beam and its position with microns resolution using position sensitive photodiodes. The set-up has been installed at the diagnostics beam line of Indus-1. Synchrotron light from photo physics beamline was reflected out by inserting a Ni coated mirror and was focused onto a duo-lateral position sensitive photodiode by using two mirrors of 1.25 meter focal length to obtain unity magnification. The set-up consists of a duo-lateral position sensitive detector (PSD), precision processing electronics and a PC based data acquisition system. A computer program captures the processed signals on to a PC using GPIB interface and displays vertical position of the beam in real time. The paper describes the salient features of the setup developed for measurement of beam stability. (author)

  20. Sensitivity of GRETINA position resolution to hole mobility

    Energy Technology Data Exchange (ETDEWEB)

    Prasher, V.S. [Department of Physics, University of Massachusetts Lowell, Lowell, MA 01854 (United States); Cromaz, M. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Merchan, E.; Chowdhury, P. [Department of Physics, University of Massachusetts Lowell, Lowell, MA 01854 (United States); Crawford, H.L. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Lister, C.J. [Department of Physics, University of Massachusetts Lowell, Lowell, MA 01854 (United States); Campbell, C.M.; Lee, I.Y.; Macchiavelli, A.O. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Radford, D.C. [Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Wiens, A. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2017-02-21

    The sensitivity of the position resolution of the gamma-ray tracking array GRETINA to the hole charge-carrier mobility parameter is investigated. The χ{sup 2} results from a fit of averaged signal (“superpulse”) data exhibit a shallow minimum for hole mobilities 15% lower than the currently adopted values. Calibration data on position resolution is analyzed, together with simulations that isolate the hole mobility dependence of signal decomposition from other effects such as electronics cross-talk. The results effectively exclude hole mobility as a dominant parameter for improving the position resolution for reconstruction of gamma-ray interaction points in GRETINA.

  1. Centroid finding method for position-sensitive detectors

    International Nuclear Information System (INIS)

    Radeka, V.; Boie, R.A.

    1979-10-01

    A new centroid finding method for all detectors where the signal charge is collected or induced on strips of wires, or on subdivided resistive electrodes, is presented. The centroid of charge is determined by convolution of the sequentially switched outputs from these subdivisions or from the strips with a linear centroid finding filter. The position line width is inversely proportional to N/sup 3/2/, where N is the number of subdivisions

  2. Centroid finding method for position-sensitive detectors

    International Nuclear Information System (INIS)

    Radeka, V.; Boie, R.A.

    1980-01-01

    A new centroid finding method for all detectors where the signal charge is collected or induced on strips or wires, or on subdivided resistive electrodes, is presented. The centroid of charge is determined by convolution of the sequentially switched outputs from these subdivisions or from the strips with a linear centroid finding filter. The position line width is inversely proportional to N 3 sup(/) 2 , where N is the number of subdivisions. (orig.)

  3. Assessing the efficiency position sensitive gaseous X-rays detectors

    International Nuclear Information System (INIS)

    Almeida, Gevaldo L. de; Souza, Maria Ines Silvani; Lopes, Ricardo T.

    2009-01-01

    Full text: The efficiency of gaseous X-ray detectors can be evaluated from tabulated data, but this approach assumes that the whole detector volume is permeated by the electrostatic field produced by the anode-cathode. Indeed, the usual detectors are comprised by a cylindrical hull acting as cathode containing a wire at its axis as anode, a configuration which foods the space between them with the electrostatic field. Some specially designed detectors, however, as Position Sensitive Detectors, contain regions which are not submitted to the electrostatic field, and hence, their efficiency could not be assessed from the tabulated data. Direct measurements of this efficiency would require a mono-chromator or set of pure mono-energetic X-rays sources. As only very few of them are really mono-energetic, the detector response to a given energy would be spoiled by to the concomitant contribution of other energies. Yet, the information would not be completely lost, but only concealed due to the convolution carried out by the detector. Therefore, a proper unfolding would be capable to recover the information, yielding the individual detector efficiency for each of the contributing energies. The degraded information is retrieved in this work through a proper mathematical unfolding of the detector response, when exposed to Bremsstrahlung spectra from an X-ray tube submitted to different voltages. For this purpose, Lorentzian functions have been fitted to these spectra - obtained with a NaI(Tl) spectrometer - in order to characterize them with proper parameters. The mathematical convolution of these functions with a theoretical detector efficiency curve yields, after integration, values which, confronted with those experimentally measured, allow the determination of the parameters of the efficiency curve. As some parameters of this curve are well known, it is possible to represent it by proper functions. For argon-filled detectors, for instance, this efficiency has a

  4. Long bunch trains measured using a prototype cavity beam position monitor for the Compact Linear Collider

    Directory of Open Access Journals (Sweden)

    F. J. Cullinan

    2015-11-01

    Full Text Available The Compact Linear Collider (CLIC requires beam position monitors (BPMs with 50 nm spatial resolution for alignment of the beam line elements in the main linac and beam delivery system. Furthermore, the BPMs must be able to make multiple independent measurements within a single 156 ns long bunch train. A prototype cavity BPM for CLIC has been manufactured and tested on the probe beam line at the 3rd CLIC Test Facility (CTF3 at CERN. The transverse beam position is determined from the electromagnetic resonant modes excited by the beam in the two cavities of the pickup, the position cavity and the reference cavity. The mode that is measured in each cavity resonates at 15 GHz and has a loaded quality factor that is below 200. Analytical expressions for the amplitude, phase and total energy of signals from long trains of bunches have been derived and the main conclusions are discussed. The results of the beam tests are presented. The variable gain of the receiver electronics has been characterized using beam excited signals and the form of the signals for different beam pulse lengths with the 2/3  ns bunch spacing has been observed. The sensitivity of the reference cavity signal to charge and the horizontal position signal to beam offset have been measured and are compared with theoretical predictions based on laboratory measurements of the BPM pickup and the form of the resonant cavity modes as determined by numerical simulation. Finally, the BPM was calibrated so that the beam position jitter at the BPM location could be measured. It is expected that the beam jitter scales linearly with the beam size and so the results are compared to predicted values for the latter.

  5. Long bunch trains measured using a prototype cavity beam position monitor for the Compact Linear Collider

    Science.gov (United States)

    Cullinan, F. J.; Boogert, S. T.; Farabolini, W.; Lefevre, T.; Lunin, A.; Lyapin, A.; Søby, L.; Towler, J.; Wendt, M.

    2015-11-01

    The Compact Linear Collider (CLIC) requires beam position monitors (BPMs) with 50 nm spatial resolution for alignment of the beam line elements in the main linac and beam delivery system. Furthermore, the BPMs must be able to make multiple independent measurements within a single 156 ns long bunch train. A prototype cavity BPM for CLIC has been manufactured and tested on the probe beam line at the 3rd CLIC Test Facility (CTF3) at CERN. The transverse beam position is determined from the electromagnetic resonant modes excited by the beam in the two cavities of the pickup, the position cavity and the reference cavity. The mode that is measured in each cavity resonates at 15 GHz and has a loaded quality factor that is below 200. Analytical expressions for the amplitude, phase and total energy of signals from long trains of bunches have been derived and the main conclusions are discussed. The results of the beam tests are presented. The variable gain of the receiver electronics has been characterized using beam excited signals and the form of the signals for different beam pulse lengths with the 2 /3 ns bunch spacing has been observed. The sensitivity of the reference cavity signal to charge and the horizontal position signal to beam offset have been measured and are compared with theoretical predictions based on laboratory measurements of the BPM pickup and the form of the resonant cavity modes as determined by numerical simulation. Finally, the BPM was calibrated so that the beam position jitter at the BPM location could be measured. It is expected that the beam jitter scales linearly with the beam size and so the results are compared to predicted values for the latter.

  6. Position sensitivity of the first SmartPET HPGe detector

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, R.J. [Department of Physics, University of Liverpool, Liverpool (United Kingdom)]. E-mail: rjc@ns.ph.liv.ac.uk; Turk, G. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Boston, A.J. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Boston, H.C. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Cresswell, J.R. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Mather, A.R. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Nolan, P.J. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Hall, C.J. [CCLRC Daresbury, Warrington, Cheshire (United Kingdom); Lazarus, I. [CCLRC Daresbury, Warrington, Cheshire (United Kingdom); Simpson, J. [CCLRC Daresbury, Warrington, Cheshire (United Kingdom); Berry, A. [School of Physics and materials Engineering, Monash University, Melbourne (Australia); Beveridge, T. [School of Physics and materials Engineering, Monash University, Melbourne (Australia); Gillam, J. [School of Physics and materials Engineering, Monash University, Melbourne (Australia); Lewis, R.A. [School of Physics and materials Engineering, Monash University, Melbourne (Australia)

    2007-04-01

    In this paper we discuss the Smart Positron Emission Tomography (PET) imaging system being developed by University of Liverpool in conjunction with CCLRC Daresbury Laboratory. We describe the motivation for the development of a semiconductor-based PET system and the advantages it will offer over current tomographs. Details of the detectors and associated electronics are discussed and results of high precision scans are presented. Analysis of this scan data has facilitated full characterization of the detector response function and calibration of the three-dimensional position sensitivity. This work presents the analysis of the depth sensitivity of the detector.

  7. Depression reduces perceptual sensitivity for positive words and pictures.

    Science.gov (United States)

    Atchley, Ruth Ann; Ilardi, Stephen S; Young, Keith M; Stroupe, Natalie N; O'Hare, Aminda J; Bistricky, Steven L; Collison, Elizabeth; Gibson, Linzi; Schuster, Jonathan; Lepping, Rebecca J

    2012-01-01

    There is evidence of maladaptive attentional biases for lexical information (e.g., Atchley, Ilardi, & Enloe, 2003; Atchley, Stringer, Mathias, Ilardi, & Minatrea, 2007) and for pictographic stimuli (e.g., Gotlib, Krasnoperova, Yue, & Joormann, 2004) among patients with depression. The current research looks for depressotypic processing biases among depressed out-patients and non-clinical controls, using both verbal and pictorial stimuli. A d' measure (sensitivity index) was used to examine each participant's perceptual sensitivity threshold. Never-depressed controls evidenced a detection bias for positive picture stimuli, while depressed participants had no such bias. With verbal stimuli, depressed individuals showed specific decrements in the detection of positive person-referent words (WINNER), but not with positive non-person-referent words (SUNSHINE) or with negative words. Never-depressed participants showed no such differences across word types. In the current study, depression is characterised both by an absence of the normal positivistic biases seen in individuals without mood disorders (consistent with McCabe & Gotlib, 1995), and by a specific reduction in sensitivity for person-referent positive information that might be inconsistent with depressotypic self-schemas.

  8. Sensitivity theory for general non-linear algebraic equations with constraints

    International Nuclear Information System (INIS)

    Oblow, E.M.

    1977-04-01

    Sensitivity theory has been developed to a high state of sophistication for applications involving solutions of the linear Boltzmann equation or approximations to it. The success of this theory in the field of radiation transport has prompted study of possible extensions of the method to more general systems of non-linear equations. Initial work in the U.S. and in Europe on the reactor fuel cycle shows that the sensitivity methodology works equally well for those non-linear problems studied to date. The general non-linear theory for algebraic equations is summarized and applied to a class of problems whose solutions are characterized by constrained extrema. Such equations form the basis of much work on energy systems modelling and the econometrics of power production and distribution. It is valuable to have a sensitivity theory available for these problem areas since it is difficult to repeatedly solve complex non-linear equations to find out the effects of alternative input assumptions or the uncertainties associated with predictions of system behavior. The sensitivity theory for a linear system of algebraic equations with constraints which can be solved using linear programming techniques is discussed. The role of the constraints in simplifying the problem so that sensitivity methodology can be applied is highlighted. The general non-linear method is summarized and applied to a non-linear programming problem in particular. Conclusions are drawn in about the applicability of the method for practical problems

  9. Stability Tests of Positive Fractional Continuous-time Linear Systems with Delays

    Directory of Open Access Journals (Sweden)

    Tadeusz Kaczorek

    2013-06-01

    Full Text Available Necessary and sufficient conditions for the asymptotic stability of positive fractional continuous-time linear systems with many delays are established. It is shown that: 1 the asymptotic stability of the positive fractional system is independent of their delays, 2 the checking of the asymptotic stability of the positive fractional systems with delays can be reduced to checking of the asymptotic stability of positive standard linear systems without delays.

  10. Position-sensitive gaseous photomultipliers research and applications

    CERN Document Server

    Francke, Tom; Peskov, Vladimir

    2016-01-01

    Gaseous photomultipliers are defined as gas-filled devices capable of recording single ultraviolet (UV) and visible photons with high position resolution. Used in a variety of research areas, these detectors can be paired with computers to treat and store imaging information of UV-light. Position-Sensitive Gaseous Photomultipliers: Research and Applications explores the advancement of gaseous detectors as applied for single photon detection. Emphasizing emerging perspectives and new ways to apply gaseous detectors across research fields, this research-based publication is an essential reference source for engineers, physicists, graduate-level students, and researchers.

  11. Cylinder gauge measurement using a position sensitive detector

    International Nuclear Information System (INIS)

    St John, W. Doyle

    2007-01-01

    A position sensitive detector (PSD) has been used to determine the diameter of cylindrical pins based on the shift in a laser beam's centroid. The centroid of the light beam is defined here as the weighted average of position by the local intensity. A shift can be observed in the centroid of an otherwise axially symmetric light beam, which is partially obstructed. Additionally, the maximum shift in the centroid is a unique function of the obstructing cylinder diameter. Thus to determine the cylinder diameter, one only needs to detect this maximum shift as the cylinder is swept across the beam

  12. Structural Investigations using a position sensitive Neutron Detector

    International Nuclear Information System (INIS)

    Fruchart, D.; Anne, M.; Wolfers, P.; Lartigue, C.; Roudaut, E.

    1986-01-01

    In the accurate determination of the location of lights atoms such as hydrogen in a metal matrix, several types of difficulty may be encountered. Experimentally, neutron diffraction is the most convenient method for such a structure determination. The use of Position Sensitive Detectors is discussed, and selected examples illustrate the advantages and drawbacks of this type of instrument. Judging from present results, significant improvements in recording technique, data collection and reduction, and structure refinement may be obtained in the near future

  13. A novel method for assessing position-sensitive detector performance

    International Nuclear Information System (INIS)

    Clinthorne, N.H.; Rogers, W.L.; Shao, L.; Hero, A.O. III; Koral, K.F.

    1989-01-01

    A marked point process model of a position-sensitive detector is developed which includes the effects of detector efficiency, spatial response, energy response, and source statistics. The average mutual information between the incident distribution of γ rays and the detector response is derived and used as a performance index for detector optimization. A brief example is presented which uses this figure-of-merit for optimization of light guide dimensions for a modular scintillation camera

  14. POSITIVE SOLUTIONS TO SEMI-LINEAR SECOND-ORDER ORDINARY DIFFERENTIAL EQUATIONS IN BANACH SPACE

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper,we study the existence of positive periodic solution to some second- order semi-linear differential equation in Banach space.By the fixed point index theory, we prove that the semi-linear differential equation has two positive periodic solutions.

  15. Development of a sub-nanometer positioning device: combining a new linear motor with linear motion ball guide ways

    International Nuclear Information System (INIS)

    Otsuka, J; Tanaka, T; Masuda, I

    2010-01-01

    A new type of linear motor described in this note has some advantages compared with conventional motors. The attractive magnetic force between the stator (permanent magnets) and mover (armature) is diminished almost to zero. The efficiency is better because the magnetic flux leakage is very small, the size of motor is smaller and detent (force ripple) is smaller than for conventional motors. Therefore, we think that this motor is greatly suitable for ultra-precision positioning as an actuator. An ultra-precision positioning device using this motor and linear motion ball guide ways is newly developed by making the device very rigid and using a suitable control method. Moreover, the positioning performance is evaluated by a positioning resolution, and deviation and dispersion errors. As a result of repeated step response tests, the positioning resolution is 0.3 nm, with the deviation error and dispersion error (3σ) being sub-nanometer. Consequently, the positioning device achieves sub-nanometer positioning. (technical design note)

  16. Sensitivity analysis of linear programming problem through a recurrent neural network

    Science.gov (United States)

    Das, Raja

    2017-11-01

    In this paper we study the recurrent neural network for solving linear programming problems. To achieve optimality in accuracy and also in computational effort, an algorithm is presented. We investigate the sensitivity analysis of linear programming problem through the neural network. A detailed example is also presented to demonstrate the performance of the recurrent neural network.

  17. Definition of a reference metrology network for the positioning of a large linear accelerator

    International Nuclear Information System (INIS)

    Becker, F.

    2003-12-01

    This thesis is a study of the Compact Linear Collider (CLIC) alignment system, a project of linear accelerator of about 30 km long of the European Organization for Nuclear Research (CERN). The pre-alignment tolerance on the transverse positions of the components of the CLIC linacs is typically ten microns over distances of 200 m. This research is a consequence of 10 years work, where several sets of special sensors dedicated to metrology have been adapted for the CLIC project. Most of these sensors deliver measurements linked to geometric references sensitive to gravity fluctuation. An important part of this work is therefore dedicated to study the gravity disruptions as a high level of accuracy is required. The parameters to take into account in the use of the hydrostatic leveling have thus been highlighted. A proposal of configuration of the system alignment based on a selection of sensors has also been given in this research. Computer models of different possible configurations have been presented. As the existing computing software was inappropriate, a new object oriented software package has been developed, to ensure future upgrades. An optimized configuration of the network has been defined from a set of simulations. Finally, due to problems in the use of hydrostatic leveling systems, a solution based on the use of a long laser beam as an alternative solution is discussed. (author)

  18. Position-Sensitive Organic Scintillation Detectors for Nuclear Material Accountancy

    International Nuclear Information System (INIS)

    Hausladen, P.; Newby, J.; Blackston, M.

    2015-01-01

    Recent years have seen renewed interest in fast organic scintillators with pulse shape properties that enable neutron-gamma discrimination, in part because of the present shortage of He3, but primarily because of the diagnostic value of timing and pulse height information available from such scintillators. Effort at Oak Ridge National Laboratory (ORNL) associated with fast organic scintillators has concentrated on development of position-sensitive fast-neutron detectors for imaging applications. Two aspects of this effort are of interest. First, the development has revisited the fundamental limitations on pulseshape measurement imposed by photon counting statistics, properties of the scintillator, and properties of photomultiplier amplification. This idealized limit can then be used to evaluate the performance of the detector combined with data acquisition and analysis such as free-running digitizers with embedded algorithms. Second, the development of position sensitive detectors has enabled a new generation of fast-neutron imaging instruments and techniques with sufficient resolution to give new capabilities relevant to safeguards. Toward this end, ORNL has built and demonstrated a number of passive and active fast-neutron imagers, including a proof-of-concept passive imager capable of resolving individual fuel pins in an assembly via their neutron emanations. This presentation will describe the performance and construction of position-sensing fast-neutron detectors and present results of imaging measurements. (author)

  19. Reduction of digital errors of digital charge division type position-sensitive detectors

    International Nuclear Information System (INIS)

    Uritani, A.; Yoshimura, K.; Takenaka, Y.; Mori, C.

    1994-01-01

    It is well known that ''digital errors'', i.e. differential non-linearity, appear in a position profile of radiation interactions when the profile is obtained with a digital charge-division-type position-sensitive detector. Two methods are presented to reduce the digital errors. They are the methods using logarithmic amplifiers and a weighting function. The validities of these two methods have been evaluated mainly by computer simulation. These methods can considerably reduce the digital errors. The best results are obtained when both methods are applied. ((orig.))

  20. Computed tomography with thermal neutrons and gaseous position sensitive detector

    International Nuclear Information System (INIS)

    Souza, Maria Ines Silvani

    2001-12-01

    A third generation tomographic system using a parallel thermal neutron beam and gaseous position sensitive detector has been developed along three discrete phases. At the first one, X-ray tomographic images of several objects, using a position sensitive detector designed and constructed for this purpose have been obtained. The second phase involved the conversion of that detector for thermal neutron detection, by using materials capable to convert neutrons into detectable charged particles, testing afterwards its performance in a tomographic system by evaluation the quality of the image arising from several test-objects containing materials applicable in the engineering field. High enriched 3 He, replacing the argon-methane otherwise used as filling gas for the X-ray detection, as well as, a gadolinium foil, have been utilized as converters. Besides the pure enriched 3 He, its mixture with argon-methane and later on with propane, have been also tested, in order to evaluate the detector efficiency and resolution. After each gas change, the overall performance of the tomographic system using the modified detector, has been analyzed through measurements of the related parameters. This was done by analyzing the images produced by test-objects containing several materials having well known attenuation coefficients for both thermal neutrons and X-rays. In order to compare the performance of the position sensitive detector as modified to detect thermal neutrons, with that of a conventional BF 3 detector, additional tomographs have been conducted using the last one. The results have been compared in terms of advantages, handicaps and complementary aspects for different kinds of radiation and materials. (author)

  1. Application of position-sensitive detectors to positron imaging

    International Nuclear Information System (INIS)

    Yamashita, Takaji; Uchida, Hiroshi; Watanabe, Mitsuo; Omura, Tomohide

    1994-01-01

    Positron imaging including positron emission tomography (PET) is expected to be a promising tool for basic and clinical research, because it makes possible the study of regional chemistry within multiple organs of the body in living human beings and experimental animals. New schemes of high resolution block detectors have been developed to improve the performance of positron imaging systems, which employ small segments of bismuth germanate (BGO) arrays and position-sensitive photomultiplier tubes (PS-PMT). The coincidence detector resolution of less than 2.0 mm in full width at half maximum was achieved with the detectors, which is very close to the theoretical resolution limit in positron imaging. (author)

  2. Fast readout of scintillating fibres using position-sensitive photomultipliers

    International Nuclear Information System (INIS)

    Agoritsas, V.; Akchurin, N.; Bergdolt, A.M.; Bing, O.; Bravar, A.; Ditta, J.; Dufournaud, J.; Dyachenko, V.A.; Giacomich, R.; Gorin, A.M.; Kuroda, K.; Magaudda, D.; Newsom, C.; Okada, K.; Onel, Y.; Penzo, A.; Rakhmatov, V.Ye.; Rykalin, V.I.; Salvato, G.; Savin, A.A.; Schiavon, P.; Sillou, D.; Solovyov, Yu.A.; Takeutchi, F.; Tareb-Reyes, M.; Vasilchenko, V.G.; Yoshida, T.; Zaychenko, A.A.

    1994-01-01

    Major progress has recently been achieved in the fast readout of scintillating fibres using position-sensitive photomultipliers (PSPMs). Experimental results obtained with commercially available PSPMs already show a space resolution better than 200 μm, a time resolution of about 1.5 ns with a detection efficiency higher than 90%, and the possibility of separating double hits with a minimum distance of ∼3 mm. An upgrade of PSPMs based on new dynode structures is also in progress. Results obtained with one new PSPM prototype in a magnetic field are also presented. (orig.)

  3. Emulation workbench for position sensitive gaseous scintillation detectors

    International Nuclear Information System (INIS)

    Pereira, L.; Margato, L.M.S.; Morozov, A.; Solovov, V.; Fraga, F. A. F.

    2015-01-01

    Position sensitive detectors based on gaseous scintillation proportional counters with Anger-type readout are being used in several research areas such as neutron detection, search for dark matter and neutrinoless double beta decay. Design and optimization of such detectors are complex and time consuming tasks. Simulations, while being a powerful tool, strongly depend on the light transfer models and demand accurate knowledge of many parameters, which are often not available. Here we describe an alternative approach based on the experimental evaluation of a detector using an isotropic point-like light source with precisely controllable light emission properties, installed on a 3D positioning system. The results obtained with the developed setup at validation conditions, when the scattered light is strongly suppressed show good agreement with simulations

  4. First investigation of a novel 2D position-sensitive

    CERN Document Server

    Bassignana, D; Jaramillo, R; Lozano, M; Munoz, F J; Pellegrini, G; Quirion, D; Vila, I

    2012-01-01

    This paper presents a first study of the performance of a novel 2D position-sensitive microstrip detector, where the resistive charge division method was implemented by replacing the metallic electrodes with resistive electrodes made of polycrystalline silicon. A characterization of two proof-of-concept prototypes with different values of the electrode resistivity was carried out using a pulsed Near Infra-Red laser. The experimental data were compared with the electrical simulation of the sensor equivalent circuit coupled to simple electronics readout circuits. The good agreement between experimental and simulation results establishes the soundness of resistive charge division method in silicon microstrip sensors and validates the developed simulation as a tool for the optimization of future sensor prototypes. Spatial resolution in the strip length direction depends on the ionizing event position. The average value obtained from the protype analysis is close to 1.2% of the strip length for a 6 MIP signal.

  5. Beam test of the 2D position sensitive neutron detector

    International Nuclear Information System (INIS)

    Tian Lichao; Chen Yuanbo; Sun Zhijia; Tang Bin; Zhou Jianrong; Qi Huirong; Liu Rongguang; Zhang Jian; Yang Guian; Xu Hong

    2014-01-01

    China Spallation Neutron Source (CSNS), one of the Major scientific apparatuses of the national Eleventh Five-Year Plane, is under construction and three spectrumeters will be constructed in the first phase of the project. A 2D position sensitive neutron detector has been constructed for the Multifunctional Reflect spectrumeter (MR) in Institute of High Energy Physics (IHEP). The basic operation principle of the detector and the test on the residual stress diffractometer of Chinese Advanced Research Reactor (CARR) in China Institute of Atomic Energy (CIAE) is introduced in this paper. The results show that it has a good position resolution of l.18 mm (FWHM) for the neutrons of l.37 A and 2D imaging ability, which is consistent with the theory. It can satisfy the requirements of MR and lays the foundation for the construction of larger neutron detectors. (authors)

  6. On the Linearized Darboux Equation Arising in Isometric Embedding of the Alexandrov Positive Annulus

    Institute of Scientific and Technical Information of China (English)

    Chunhe LI

    2013-01-01

    In the present paper,the solvability condition of the linearized Gauss-Codazzi system and the solutions to the homogenous system are given.In the meantime,the Solvability of a relevant linearized Darboux equation is given.The equations are arising in a geometric problem which is concerned with the realization of the Alexandrov's positive annulus in R3.

  7. Flat Panel PMT: advances in position sensitive photodetection

    International Nuclear Information System (INIS)

    Pani, R.; Pellegrini, R.; Trotta, C.; Cinti, M.N.; Bennati, P.; Trotta, G.; Iurlaro, G.; Montani, L.; Ridolfi, S.; Cusanno, F.; Garibaldi, F.

    2003-01-01

    Over the last ten years there was being a strong advancement in photodetection. Different application fields are involved in their use in particular high energy physics, astrophysics and nuclear medicine. They usually work by coupling a scintillation crystal and more recent scintillation arrays with pixel size as small as 0.5 mm. PSPMT represents today the most ready technology for photodetection with large detection areas and very high spatial resolution. Flat panel PMT represents the last technological advancement. Its dimension is 50x50 mm 2 with a narrow peripheral dead zone (0.5 mm final goal). Its compactness allow to assemble different modules closely packed, achieving large detection areas with an effective active area of 97%. In this paper we analyze the imaging performances of PSPMT by coupling two scintillation arrays and by light spot scanning of photocathode to evaluate the linearity position response, spatial resolution and uniformity gain response as a function of light distribution spread and the number of photoelectrons generated on photocathode. The results point out a very narrow PMT intrinsic charge spread and low cross-talk between anodes. Energy resolution and spatial resolution show a good linearity with DRF variation. An unexpected intra-anode gain variation is carried out. In this paper we present the results obtained with this PSPMT regarding imaging performances principally addressed to nuclear medicine application

  8. Non-monotone positive solutions of second-order linear differential equations: existence, nonexistence and criteria

    Directory of Open Access Journals (Sweden)

    Mervan Pašić

    2016-10-01

    Full Text Available We study non-monotone positive solutions of the second-order linear differential equations: $(p(tx'' + q(t x = e(t$, with positive $p(t$ and $q(t$. For the first time, some criteria as well as the existence and nonexistence of non-monotone positive solutions are proved in the framework of some properties of solutions $\\theta (t$ of the corresponding integrable linear equation: $(p(t\\theta''=e(t$. The main results are illustrated by many examples dealing with equations which allow exact non-monotone positive solutions not necessarily periodic. Finally, we pose some open questions.

  9. Linear quadratic Gaussian controller design for plasma current, position and shape control system in ITER

    International Nuclear Information System (INIS)

    Belyakov, V.; Kavin, A.; Rumyantsev, E.; Kharitonov, V.; Misenov, B.; Ovsyannikov, A.; Ovsyannikov, D.; Veremei, E.; Zhabko, A.; Mitrishkin, Y.

    1999-01-01

    This paper is focused on the linear quadratic Gaussian (LQG) controller synthesis methodology for the ITER plasma current, position and shape control system as well as power derivative management system. It has been shown that some poloidal field (PF) coils have less influence on reference plasma-wall gaps control during plasma disturbances and hence they have been used to reduce total control power derivative by means of the additional non-linear feedback. The design has been done on the basis of linear models. Simulation was provided for non-linear model and results are presented and discussed. (orig.)

  10. A characterization of positive linear maps and criteria of entanglement for quantum states

    International Nuclear Information System (INIS)

    Hou Jinchuan

    2010-01-01

    Let H and K be (finite- or infinite-dimensional) complex Hilbert spaces. A characterization of positive completely bounded normal linear maps from B(H) into B(K) is given, which particularly gives a characterization of positive elementary operators including all positive linear maps between matrix algebras. This characterization is then applied to give a representation of quantum channels (operations) between infinite-dimensional systems. A necessary and sufficient criterion of separability is given which shows that a state ρ on HxK is separable if and only if (ΦxI)ρ ≥ 0 for all positive finite-rank elementary operators Φ. Examples of NCP and indecomposable positive linear maps are given and are used to recognize some entangled states that cannot be recognized by the PPT criterion and the realignment criterion.

  11. A characterization of positive linear maps and criteria of entanglement for quantum states

    Science.gov (United States)

    Hou, Jinchuan

    2010-09-01

    Let H and K be (finite- or infinite-dimensional) complex Hilbert spaces. A characterization of positive completely bounded normal linear maps from {\\mathcal B}(H) into {\\mathcal B}(K) is given, which particularly gives a characterization of positive elementary operators including all positive linear maps between matrix algebras. This characterization is then applied to give a representation of quantum channels (operations) between infinite-dimensional systems. A necessary and sufficient criterion of separability is given which shows that a state ρ on HotimesK is separable if and only if (ΦotimesI)ρ >= 0 for all positive finite-rank elementary operators Φ. Examples of NCP and indecomposable positive linear maps are given and are used to recognize some entangled states that cannot be recognized by the PPT criterion and the realignment criterion.

  12. High resolution, position sensitive detector for energetic particle beams

    International Nuclear Information System (INIS)

    Marsh, E.P.; Strathman, M.D.; Reed, D.A.; Odom, R.W.; Morse, D.H.; Pontau, A.E.

    1993-01-01

    The performance and design of an imaging position sensitive, particle beam detector will be presented. The detector is minimally invasive, operates a wide dynamic range (>10 10 ), and exhibits high spatial resolution. The secondary electrons produced when a particle beam passes through a thin foil are imaged using stigmatic ion optics onto a two-dimensional imaging detector. Due to the low scattering cross section of the 6 nm carbon foil the detector is a minimal perturbation on the primary beam. A prototype detector with an image resolution of approximately 5 μm for a field of view of 1 mm has been reported. A higher resolution detector for imaging small beams (<50 μm) with an image resolution of better than 0.5 μm has since been developed and its design is presented. (orig.)

  13. High resolution, position sensitive detector for energetic particle beams

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, E P [Charles Evans and Associates, Redwood City, CA (United States); Strathman, M D [Charles Evans and Associates, Redwood City, CA (United States); Reed, D A [Charles Evans and Associates, Redwood City, CA (United States); Odom, R W [Charles Evans and Associates, Redwood City, CA (United States); Morse, D H [Sandia National Labs., Livermore, CA (United States); Pontau, A E [Sandia National Labs., Livermore, CA (United States)

    1993-05-01

    The performance and design of an imaging position sensitive, particle beam detector will be presented. The detector is minimally invasive, operates a wide dynamic range (>10[sup 10]), and exhibits high spatial resolution. The secondary electrons produced when a particle beam passes through a thin foil are imaged using stigmatic ion optics onto a two-dimensional imaging detector. Due to the low scattering cross section of the 6 nm carbon foil the detector is a minimal perturbation on the primary beam. A prototype detector with an image resolution of approximately 5 [mu]m for a field of view of 1 mm has been reported. A higher resolution detector for imaging small beams (<50 [mu]m) with an image resolution of better than 0.5 [mu]m has since been developed and its design is presented. (orig.)

  14. One-dimensional position sensitive detector based on photonic crystals

    International Nuclear Information System (INIS)

    Xi Feng; Qin Lan; Xue Lian; Duan Ying

    2013-01-01

    Position sensitive detectors (PSDs) are an important class of optical sensors which utilizes the lateral photovoltaic effect (LPVE). According to the operation principle of PSD, we demonstrate that LPVE can be enhanced by lengthening the lifetime of photo-generated carriers. A PSD based on photonic crystals (PCs) composed of MgF 2 and InP is proposed and designed. The transmittances of the defect PC and the reflectance of the perfect PC in the PSD are obtained with transfer matrix method. The theoretical research on the designed device shows that LPVE is enhanced by improving the transmittance of the defect PC and the reflectance of the perfect PC to lengthen the lifetime of photo-generated carriers. (authors)

  15. Position sensitive detection of neutrons in high radiation background field.

    Science.gov (United States)

    Vavrik, D; Jakubek, J; Pospisil, S; Vacik, J

    2014-01-01

    We present the development of a high-resolution position sensitive device for detection of slow neutrons in the environment of extremely high γ and e(-) radiation background. We make use of a planar silicon pixelated (pixel size: 55 × 55 μm(2)) spectroscopic Timepix detector adapted for neutron detection utilizing very thin (10)B converter placed onto detector surface. We demonstrate that electromagnetic radiation background can be discriminated from the neutron signal utilizing the fact that each particle type produces characteristic ionization tracks in the pixelated detector. Particular tracks can be distinguished by their 2D shape (in the detector plane) and spectroscopic response using single event analysis. A Cd sheet served as thermal neutron stopper as well as intensive source of gamma rays and energetic electrons. Highly efficient discrimination was successful even at very low neutron to electromagnetic background ratio about 10(-4).

  16. Delay-Line Three-Dimensional Position Sensitive Radiation Detection

    Science.gov (United States)

    Jeong, Manhee

    High-resistivity silicon(Si) in large volumes and with good charge carrier transport properties has been produced and achieved success as a radiation detector material over the past few years due to its relatively low cost as well as the availability of well-established processing technologies. One application of that technology is in the fabrication of various position-sensing topologies from which the incident radiation's direction can be determined. We have succeeded in developing the modeling tools for investigating different position-sensing schemes and used those tools to examine both amplitude-based and time-based methods, an assessment that indicates that fine position-sensing can be achieved with simpler readout designs than are conventionally deployed. This realization can make ubiquitous and inexpensive deployment of special nuclear materials (SNM) detecting technology becomes more feasible because if one can deploy position-sensitive semiconductor detectors with only one or two contacts per side. For this purpose, we have described the delay-line radiation detector and its optimized fabrication. The semiconductor physics were simulated, the results from which guided the fabrication of the guard ring structure and the detector electrode, both of which included metal-field-plates. The measured improvement in the leakage current was confirmed with the fabricated devices, and the structures successfully suppressed soft-breakdown. We also demonstrated that fabricating an asymmetric strip-line structure successfully minimizing the pulse shaping and increases the distance through which one can propagate the information of the deposited charge distribution. With fabricated delay-line detectors we can acquire alpha spectra (Am-241) and gamma spectra (Ba-133, Co-57 and Cd-109). The delay-line detectors can therefore be used to extract the charge information from both ion and gamma-ray interactions. Furthermore, standard charge-sensitive circuits yield high SNR

  17. Giant negative linear compression positively coupled to massive thermal expansion in a metal-organic framework.

    Science.gov (United States)

    Cai, Weizhao; Katrusiak, Andrzej

    2014-07-04

    Materials with negative linear compressibility are sought for various technological applications. Such effects were reported mainly in framework materials. When heated, they typically contract in the same direction of negative linear compression. Here we show that this common inverse relationship rule does not apply to a three-dimensional metal-organic framework crystal, [Ag(ethylenediamine)]NO3. In this material, the direction of the largest intrinsic negative linear compression yet observed in metal-organic frameworks coincides with the strongest positive thermal expansion. In the perpendicular direction, the large linear negative thermal expansion and the strongest crystal compressibility are collinear. This seemingly irrational positive relationship of temperature and pressure effects is explained and the mechanism of coupling of compressibility with expansivity is presented. The positive coupling between compression and thermal expansion in this material enhances its piezo-mechanical response in adiabatic process, which may be used for designing new artificial composites and ultrasensitive measuring devices.

  18. Contribution to the study of position sensitive detectors with high spatial resolution for thermal neutron detection

    International Nuclear Information System (INIS)

    Idrissi Fakhr-Eddine, Abdellah.

    1978-01-01

    With a view to improving the spatial resolution of the localization of thermal neutrons, the work covers four position sensitive detectors: - 800 cell multi-detectors (1 dimension), - linear 'Jeu de Jacquet' detectors (1 dimension) - Multi-detector XYP 128x128 (2 dimensions), - 'Jeu de Jacquet' detector with 2 dimensions. Mention is made of the various position finding methods known so far, as well as the reasons for selecting BF 3 as detector gas. A study is then made of the parameters of the multiwire chamber whose principle will form the basis of most of the position detecting appliances subsequently dealt with. Finally, a description is given of the detection tests of the thermal neutrons in the multiwire chamber depending on the pressure, a parameter that greatly affects the accuracy of the position finding. The single dimension position tests on two kinds of appliance, the 800 cell multi-detector for the wide angle diffraction studies, and the linear 'Jeu de Jacquet' detector designed for small angle diffraction are mentioned. A description is then given of two position appliances with two dimensions; the multi-detector XYP 128x128 and the two dimensional 'Jeu de Jacquet' detector. In the case of this latter detector, only the hoped for characteristics are indicated [fr

  19. Comparing light sensitivity, linearity and step response of electronic cameras for ophthalmology.

    Science.gov (United States)

    Kopp, O; Markert, S; Tornow, R P

    2002-01-01

    To develop and test a procedure to measure and compare light sensitivity, linearity and step response of electronic cameras. The pixel value (PV) of digitized images as a function of light intensity (I) was measured. The sensitivity was calculated from the slope of the P(I) function, the linearity was estimated from the correlation coefficient of this function. To measure the step response, a short sequence of images was acquired. During acquisition, a light source was switched on and off using a fast shutter. The resulting PV was calculated for each video field of the sequence. A CCD camera optimized for the near-infrared (IR) spectrum showed the highest sensitivity for both, visible and IR light. There are little differences in linearity. The step response depends on the procedure of integration and read out.

  20. Position-sensitive proportional counters using resistance-capacitance position encoding

    International Nuclear Information System (INIS)

    Kopp, M.K.; Borkowski, C.J.

    1975-12-01

    A new method was developed for encoding the position of individual photons, neutrons, or charged particles in proportional counters by using the distributed RC line characteristics of these counters. The signal processing is described and guidelines for the design and operation of these position sensitive proportional counters (PSPCs) are given. Using these guidelines, several prototypic PSPCs were constructed to improve the spatial resolution and shorten the signal processing time; for example, the intrinsic spatial uncertainty was reduced to 28 μ fwhm for alpha particles and 100 μ fwhm for low-energy x rays (2 to 6 keV). Also, the signal processing time was reduced to 0.6 μsec without seriously degrading the spatial resolution. These results have opened new fields of application of the RC position encoding method in imaging distributions of photons, charged particles, or neutrons in nuclear medicine, physics, and radiography

  1. A study on virtual source position for electron beams from a Mevatron MD linear accelerator

    International Nuclear Information System (INIS)

    Ravindran, B.P.

    1999-01-01

    The virtual source position (VSP) for electron beams of energies 5, 7, 9 10, 12 and 14 MeV and for the applicators (cones) available in the department have been measured for a Mevatron MD class linear accelerator. Different methods of obtaining the virtual source position for electron beams have been investigated in the present study. The results obtained have been compared with those of other workers. It is observed that the VSP is very much machine dependent and needs to be measured for each linear accelerator. The effect of shielding on virtual source position for the type of applicators available in the department has also been investigated. (author)

  2. Beam position monitor sensitivity for low-β beams

    International Nuclear Information System (INIS)

    Shafer, R.E.

    1993-01-01

    At low velocities, the EM field of a particle in a conducting beam tube is no longer a TEM wave, but has a finite longitudinal extent. The net effect of this is to reduce the coupling of the high-frequency Fourier components of the beam current to BPM (beam position monitor) electrodes, which modifies the BPM sensitivity to beam displacement. This effect is especially pronounced for high-frequency, large-aperture pickups used for low-β beams. Non-interceptive beam position monitors used in conjunction with high frequency RFQ (radio-frequency-quadrupole) and DTL (drift-tube-linac) accelerators fall into this category. When testing a BPM with a thin wire excited with either pulses or high-frequency sinusoidal currents, the EM wave represents the principal (TEM) mode in a coaxial transmission line, which is equivalent to a highly relativistic (β = 1) beam. Thus wire measurements are not suitable for simulating slow particle beams in high bandwidth diagnostic devices that couple to the image currents in the beam tube wall. Attempts to load the tin wire either capacitively or inductively to slow the EM wave down have met with limited success. In general, the equations used to represent the 2-D response of cylindrical-geometry BPMs to charged-particle beams make several assumptions: (1) the BPM electrodes are flush with and grounded to the surface of the conducting beam tube; (2) the beam is a line source (pencil beam); (3) the longitudinal extent of the EM field of a beam particle at the beam tube wall is zero, corresponding to a highly relativistic beam. The purpose of this paper is to make some quantitative estimates of the corrections to the conventional approximations when a BPM is used to measure the position of low velocity (low-β) beams

  3. Epidermis Microstructure Inspired Graphene Pressure Sensor with Random Distributed Spinosum for High Sensitivity and Large Linearity.

    Science.gov (United States)

    Pang, Yu; Zhang, Kunning; Yang, Zhen; Jiang, Song; Ju, Zhenyi; Li, Yuxing; Wang, Xuefeng; Wang, Danyang; Jian, Muqiang; Zhang, Yingying; Liang, Renrong; Tian, He; Yang, Yi; Ren, Tian-Ling

    2018-03-27

    Recently, wearable pressure sensors have attracted tremendous attention because of their potential applications in monitoring physiological signals for human healthcare. Sensitivity and linearity are the two most essential parameters for pressure sensors. Although various designed micro/nanostructure morphologies have been introduced, the trade-off between sensitivity and linearity has not been well balanced. Human skin, which contains force receptors in a reticular layer, has a high sensitivity even for large external stimuli. Herein, inspired by the skin epidermis with high-performance force sensing, we have proposed a special surface morphology with spinosum microstructure of random distribution via the combination of an abrasive paper template and reduced graphene oxide. The sensitivity of the graphene pressure sensor with random distribution spinosum (RDS) microstructure is as high as 25.1 kPa -1 in a wide linearity range of 0-2.6 kPa. Our pressure sensor exhibits superior comprehensive properties compared with previous surface-modified pressure sensors. According to simulation and mechanism analyses, the spinosum microstructure and random distribution contribute to the high sensitivity and large linearity range, respectively. In addition, the pressure sensor shows promising potential in detecting human physiological signals, such as heartbeat, respiration, phonation, and human motions of a pushup, arm bending, and walking. The wearable pressure sensor array was further used to detect gait states of supination, neutral, and pronation. The RDS microstructure provides an alternative strategy to improve the performance of pressure sensors and extend their potential applications in monitoring human activities.

  4. Simulation and sensitivity analysis for heavy linear paraffins production in LAB production Plant

    Directory of Open Access Journals (Sweden)

    Karimi Hajir

    2014-12-01

    Full Text Available Linear alkyl benzene (LAB is vastly utilized for the production of biodegradable detergents and emulsifiers. Predistillation unit is a part of LAB production plant in which that produced heavy linear paraffins (nC10-nC13. In this study, a mathematical model has been developed for heavy linear paraffins production in distillation columns, which has been solved using a commercial code. The models have been validated by the actual data. The effects of process parameters such as reflux rate, and reflux temperature using Gradient Search technique has been investigated. The sensitivity analysis shows that optimum reflux in columns are achieved.

  5. Vantage Sensitivity: Environmental Sensitivity to Positive Experiences as a Function of Genetic Differences.

    Science.gov (United States)

    Pluess, Michael

    2017-02-01

    A large number of gene-environment interaction studies provide evidence that some people are more likely to be negatively affected by adverse experiences as a function of specific genetic variants. However, such "risk" variants are surprisingly frequent in the population. Evolutionary analysis suggests that genetic variants associated with increased risk for maladaptive development under adverse environmental conditions are maintained in the population because they are also associated with advantages in response to different contextual conditions. These advantages may include (a) coexisting genetic resilience pertaining to other adverse influences, (b) a general genetic susceptibility to both low and high environmental quality, and (c) a coexisting propensity to benefit disproportionately from positive and supportive exposures, as reflected in the recent framework of vantage sensitivity. After introducing the basic properties of vantage sensitivity and highlighting conceptual similarities and differences with diathesis-stress and differential susceptibility patterns of gene-environment interaction, selected and recent empirical evidence for the notion of vantage sensitivity as a function of genetic differences is reviewed. The unique contribution that the new perspective of vantage sensitivity may make to our understanding of social inequality will be discussed after suggesting neurocognitive and molecular mechanisms hypothesized to underlie the propensity to benefit disproportionately from benevolent experiences. © 2015 Wiley Periodicals, Inc.

  6. Antimicrobial sensitivity pattern of gram positive CSF isolates in ...

    African Journals Online (AJOL)

    100%) to Linezolid, Vancomycin and Piperacillin-Tazobactam. However, Staphylococcus aureus were 100% sensitive to Linezolid and Vancomycin but were only 87.5% sensitive to Piperacillin-Tazobactam combination. The Streptococcus ...

  7. Speed Sensorless mixed sensitivity linear parameter variant H_inf control of the induction motor

    NARCIS (Netherlands)

    Toth, R.; Fodor, D.

    2004-01-01

    The paper shows the design of a robust control structure for the speed sensorless vector control of the IM, based on the mixed sensitivity (MS) linear parameter variant (LPV) H8 control theory. The controller makes possible the direct control of the flux and speed of the motor with torque adaptation

  8. Micosoft Excel Sensitivity Analysis for Linear and Stochastic Program Feed Formulation

    Science.gov (United States)

    Sensitivity analysis is a part of mathematical programming solutions and is used in making nutritional and economic decisions for a given feed formulation problem. The terms, shadow price and reduced cost, are familiar linear program (LP) terms to feed formulators. Because of the nonlinear nature of...

  9. Evaluation of the accuracy of linear and angular measurements on panoramic radiographs taken at different positions

    Energy Technology Data Exchange (ETDEWEB)

    Nikneshan, Sima; Emadi, Naghmeh [Dept. of Oral and Maxillofacial Radiology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran (Iran, Islamic Republic of); Sharafi, Mohamad [Dept. of Oral and Maxillofacial Radiology, Dental School, Ilam University of Medical Sciences, Ilam (Iran, Islamic Republic of)

    2013-09-15

    This study assessed the accuracy of linear and angular measurements on panoramic radiographs taken at different positions in vitro. Two acrylic models were fabricated from a cast with normal occlusion. Straight and 75 degree mesially and lingually angulated pins were placed, and standardized panoramic radiographs were taken at standard position, at an 8 degree downward tilt of the occlusal plane compared to the standard position, at an 8 degree upward tilt of the anterior occlusal plane, and at a 10 degree downward tilt of the right and left sides of the model. On the radiographs, the length of the pins above (crown) and below (root) the occlusal plane, total pin length, crown-to-root ratio, and angulation of pins relative to the occlusal plane were calculated. The data were subjected to repeated measures ANOVA and LSD multiple comparisons tests. Significant differences were noted between the radiographic measurements and true values in different positions on both models with linear (P<0.001) and those with angulated pins (P<0.005). No statistically significant differences were observed between the angular measurements and baselines of the natural head posture at different positions for the linear and angulated pins. Angular measurements on panoramic radiographs were sufficiently accurate and changes in the position of the occlusal plane equal to or less than 10 degree had no significant effect on them. Some variations could exist in the pin positioning (head positioning), and they were tolerable while taking panoramic radiographs. Linear measurements showed the least errors in the standard position and 8 degree upward tilt of the anterior part of the occlusal plane compared to other positions.

  10. Position Control of Linear Synchronous Motor Drives with Exploitation of Forced Dynamics Control Principles

    Directory of Open Access Journals (Sweden)

    Jan Vittek

    2004-01-01

    Full Text Available Closed-loop position control of mechanisms directly driven by linear synchronous motors with permanent magnets is presented. The control strategy is based on forced dynamic control, which is a form of feedback linearisation, yielding a non-liner multivariable control law to obtain a prescribed linear speed dynamics together with the vector control condition of mutal orthogonality between the stator current and magnetic flux vectors (assuming perfect estimates of the plant parameters. Outer position control loop is closed via simple feedback with proportional gain. Simulations of the design control sysstem, including the drive with power electronic switching, predict the intended drive performance.

  11. Sensitivity-based virtual fields for the non-linear virtual fields method

    Science.gov (United States)

    Marek, Aleksander; Davis, Frances M.; Pierron, Fabrice

    2017-09-01

    The virtual fields method is an approach to inversely identify material parameters using full-field deformation data. In this manuscript, a new set of automatically-defined virtual fields for non-linear constitutive models has been proposed. These new sensitivity-based virtual fields reduce the influence of noise on the parameter identification. The sensitivity-based virtual fields were applied to a numerical example involving small strain plasticity; however, the general formulation derived for these virtual fields is applicable to any non-linear constitutive model. To quantify the improvement offered by these new virtual fields, they were compared with stiffness-based and manually defined virtual fields. The proposed sensitivity-based virtual fields were consistently able to identify plastic model parameters and outperform the stiffness-based and manually defined virtual fields when the data was corrupted by noise.

  12. Mover Position Detection for PMTLM Based on Linear Hall Sensors through EKF Processing.

    Science.gov (United States)

    Yan, Leyang; Zhang, Hui; Ye, Peiqing

    2017-04-06

    Accurate mover position is vital for a permanent magnet tubular linear motor (PMTLM) control system. In this paper, two linear Hall sensors are utilized to detect the mover position. However, Hall sensor signals contain third-order harmonics, creating errors in mover position detection. To filter out the third-order harmonics, a signal processing method based on the extended Kalman filter (EKF) is presented. The limitation of conventional processing method is first analyzed, and then EKF is adopted to detect the mover position. In the EKF model, the amplitude of the fundamental component and the percentage of the harmonic component are taken as state variables, and they can be estimated based solely on the measured sensor signals. Then, the harmonic component can be calculated and eliminated. The proposed method has the advantages of faster convergence, better stability and higher accuracy. Finally, experimental results validate the effectiveness and superiority of the proposed method.

  13. Linearization of Positional Response Curve of a Fiber-optic Displacement Sensor

    Science.gov (United States)

    Babaev, O. G.; Matyunin, S. A.; Paranin, V. D.

    2018-01-01

    Currently, the creation of optical measuring instruments and sensors for measuring linear displacement is one of the most relevant problems in the area of instrumentation. Fiber-optic contactless sensors based on the magneto-optical effect are of special interest. They are essentially contactless, non-electrical and have a closed optical channel not subject to contamination. The main problem of this type of sensors is the non-linearity of their positional response curve due to the hyperbolic nature of the magnetic field intensity variation induced by moving the magnetic source mounted on the controlled object relative to the sensing element. This paper discusses an algorithmic method of linearizing the positional response curve of fiber-optic displacement sensors in any selected range of the displacements to be measured. The method is divided into two stages: 1 - definition of the calibration function, 2 - measurement and linearization of the positional response curve (including its temperature stabilization). The algorithm under consideration significantly reduces the number of points of the calibration function, which is essential for the calibration of temperature dependence, due to the use of the points that randomly deviate from the grid points with uniform spacing. Subsequent interpolation of the deviating points and piecewise linear-plane approximation of the calibration function reduces the microcontroller storage capacity for storing the calibration function and the time required to process the measurement results. The paper also presents experimental results of testing real samples of fiber-optic displacement sensors.

  14. Flexible Ferroelectric Sensors with Ultrahigh Pressure Sensitivity and Linear Response over Exceptionally Broad Pressure Range.

    Science.gov (United States)

    Lee, Youngoh; Park, Jonghwa; Cho, Soowon; Shin, Young-Eun; Lee, Hochan; Kim, Jinyoung; Myoung, Jinyoung; Cho, Seungse; Kang, Saewon; Baig, Chunggi; Ko, Hyunhyub

    2018-04-24

    Flexible pressure sensors with a high sensitivity over a broad linear range can simplify wearable sensing systems without additional signal processing for the linear output, enabling device miniaturization and low power consumption. Here, we demonstrate a flexible ferroelectric sensor with ultrahigh pressure sensitivity and linear response over an exceptionally broad pressure range based on the material and structural design of ferroelectric composites with a multilayer interlocked microdome geometry. Due to the stress concentration between interlocked microdome arrays and increased contact area in the multilayer design, the flexible ferroelectric sensors could perceive static/dynamic pressure with high sensitivity (47.7 kPa -1 , 1.3 Pa minimum detection). In addition, efficient stress distribution between stacked multilayers enables linear sensing over exceptionally broad pressure range (0.0013-353 kPa) with fast response time (20 ms) and high reliability over 5000 repetitive cycles even at an extremely high pressure of 272 kPa. Our sensor can be used to monitor diverse stimuli from a low to a high pressure range including weak gas flow, acoustic sound, wrist pulse pressure, respiration, and foot pressure with a single device.

  15. Approximation of functions in two variables by some linear positive operators

    Directory of Open Access Journals (Sweden)

    Mariola Skorupka

    1995-12-01

    Full Text Available We introduce some linear positive operators of the Szasz-Mirakjan type in the weighted spaces of continuous functions in two variables. We study the degree of the approximation of functions by these operators. The similar results for functions in one variable are given in [5]. Some operators of the Szasz-Mirakjan type are examined also in [3], [4].

  16. Investigation of the pulse shape analysis for the position sensitive γ-ray spectrometer AGATA

    Energy Technology Data Exchange (ETDEWEB)

    Lewandowski, Lars; Birkenbach, Benedikt; Reiter, Peter [Institut fuer Kernphysik Koeln (Germany); Collaboration: AGATA-Collaboration

    2015-07-01

    The next generation of γ-ray spectrometers like AGATA will provide high quality γ-ray spectra by the new Gamma-Ray Tracking technique (GRT). Position sensitive HPGe detectors will allow for precise Doppler correction and small broadening of lines for spectroscopy at relativistic energies. GRT is based on the interaction position of the γ-rays within the volume of the highly segmented germanium detectors provided by Pulse Shape Analysis (PSA) methods. The proof of principle of GRT was already demonstrated with great success however systematic deviations from expected results occur. The parameterization of the following detector properties and their impact on PSA were thoroughly investigated and optimized: electron and hole mobility, crystal axis orientation, space charge distributions, crystal impurities, response functions of preamplifiers and digitizers, linear and differential crosstalk, time alignment of pulses and the distance metric. Results of an improved PSA performance are presented.

  17. Instrumentation for Position Sensitive Detector-Powder diffractometer at CENM-Maamora

    International Nuclear Information System (INIS)

    Messous, M.-Y.; Belhorma, B.; Labrim, H.; El-Bakkari, B.; Jabri, H.

    2013-06-01

    Linear position sensitive detectors are widely used to configure neutron diffractometer and other instruments. Necessary front-end electronics and data acquisition system was developed to fulfil such instruments built around the research reactor. In this paper, the front-end electronics dedicated to the neutron powder diffractometer which will be installed in the axial beam port of the Triga Mark II research reactor (Center of Nuclear Studies of Maamora) is described. It consists of High voltage power supply, a Position-decoder and a Multichannel analyzer and data acquisition software. The 3 He-PSD detector response exposed to the neutron flow emitted by 252 Cf source held in paraffin spheres with distinct thicknesses for moderation effect, is shown. Monte-Carlo N Particles code (MCNP) simulations were also performed to study both the detector performance and the paraffin efficiency. (authors)

  18. Predictive IP controller for robust position control of linear servo system.

    Science.gov (United States)

    Lu, Shaowu; Zhou, Fengxing; Ma, Yajie; Tang, Xiaoqi

    2016-07-01

    Position control is a typical application of linear servo system. In this paper, to reduce the system overshoot, an integral plus proportional (IP) controller is used in the position control implementation. To further improve the control performance, a gain-tuning IP controller based on a generalized predictive control (GPC) law is proposed. Firstly, to represent the dynamics of the position loop, a second-order linear model is used and its model parameters are estimated on-line by using a recursive least squares method. Secondly, based on the GPC law, an optimal control sequence is obtained by using receding horizon, then directly supplies the IP controller with the corresponding control parameters in the real operations. Finally, simulation and experimental results are presented to show the efficiency of proposed scheme. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  19. A Monolithic CMOS Magnetic Hall Sensor with High Sensitivity and Linearity Characteristics.

    Science.gov (United States)

    Huang, Haiyun; Wang, Dejun; Xu, Yue

    2015-10-27

    This paper presents a fully integrated linear Hall sensor by means of 0.8 μm high voltage complementary metal-oxide semiconductor (CMOS) technology. This monolithic Hall sensor chip features a highly sensitive horizontal switched Hall plate and an efficient signal conditioner using dynamic offset cancellation technique. An improved cross-like Hall plate achieves high magnetic sensitivity and low offset. A new spinning current modulator stabilizes the quiescent output voltage and improves the reliability of the signal conditioner. The tested results show that at the 5 V supply voltage, the maximum Hall output voltage of the monolithic Hall sensor microsystem, is up to ±2.1 V and the linearity of Hall output voltage is higher than 99% in the magnetic flux density range from ±5 mT to ±175 mT. The output equivalent residual offset is 0.48 mT and the static power consumption is 20 mW.

  20. Chemical networks with inflows and outflows: a positive linear differential inclusions approach.

    Science.gov (United States)

    Angeli, David; De Leenheer, Patrick; Sontag, Eduardo D

    2009-01-01

    Certain mass-action kinetics models of biochemical reaction networks, although described by nonlinear differential equations, may be partially viewed as state-dependent linear time-varying systems, which in turn may be modeled by convex compact valued positive linear differential inclusions. A result is provided on asymptotic stability of such inclusions, and applied to a ubiquitous biochemical reaction network with inflows and outflows, known as the futile cycle. We also provide a characterization of exponential stability of general homogeneous switched systems which is not only of interest in itself, but also plays a role in the analysis of the futile cycle. 2009 American Institute of Chemical Engineers

  1. Stability, performance and sensitivity analysis of I.I.D. jump linear systems

    Science.gov (United States)

    Chávez Fuentes, Jorge R.; González, Oscar R.; Gray, W. Steven

    2018-06-01

    This paper presents a symmetric Kronecker product analysis of independent and identically distributed jump linear systems to develop new, lower dimensional equations for the stability and performance analysis of this type of systems than what is currently available. In addition, new closed form expressions characterising multi-parameter relative sensitivity functions for performance metrics are introduced. The analysis technique is illustrated with a distributed fault-tolerant flight control example where the communication links are allowed to fail randomly.

  2. Development of a new signal processor for tetralateral position sensitive detector based on single-chip microcomputer

    International Nuclear Information System (INIS)

    Huang Meizhen; Shi Longzhao; Wang Yuxing; Ni Yi; Li Zhenqing; Ding Haifeng

    2006-01-01

    An inherently nonlinear relation between the output current of the tetralateral position sensitive detector (PSD) and the position of the incident light spot has been found theoretically. Based on single-chip microcomputer and the theoretical relation between output current and position, a new signal processor capable of correcting nonlinearity and reducing position measurement deviation of tetralateral PSD was developed. A tetralateral PSD (S1200, 13x13 mm 2 , Hamamatsu Photonics K.K.) was measured with the new signal processor, a linear relation between the output position of the PSD, and the incident position of the light spot was obtained. In the 60% range of a 13x13 mm 2 active area, the position nonlinearity (rms) was 0.15% and the position measurement deviation (rms) was ±20 μm. Compared with traditional analog signal processor, the new signal processor is of better compatibility, lower cost, higher precision, and easier to be interfaced

  3. Positivity and job burnout in emergency personnel: examining linear and curvilinear relationship

    Directory of Open Access Journals (Sweden)

    Basińska Beata Aleksandra

    2017-06-01

    Full Text Available The aim of this study was to examine whether the relationship between the ratio of job-related positive to negative emotions (positivity ratio and job burnout is best described as linear or curvilinear. Participants were 89 police officers (12% women and 86 firefighters. The positivity ratio was evaluated using the Job-related Affective Wellbeing Scale (Van Katwyk, Fox, Spector, & Kelloway, 2000. Exhaustion and disengagement, two components of job burnout, were measured using the Oldenburg Burnout Inventory (Demerouti, Mostert, & Bakker, 2010. The results of regression analysis revealed that curvilinear relationships between the positivity ratio and two components of job burnout appeared to better fit the data than linear relationships. The relationship between the positivity ratio and exhaustion was curvilinear with a curve point at around 2.1. A similar curvilinear relationship, but with a lower curve point, i.e., around 1.8, was observed for disengagement. It seems that beyond certain values there may be hidden costs of maintaining positive emotions at work. Also, the unequal curve points for subscales suggest that different dimensions of work-related functioning are variously prone to such costs.

  4. Wireless Positioning Based on a Segment-Wise Linear Approach for Modeling the Target Trajectory

    DEFF Research Database (Denmark)

    Figueiras, Joao; Pedersen, Troels; Schwefel, Hans-Peter

    2008-01-01

    Positioning solutions in infrastructure-based wireless networks generally operate by exploiting the channel information of the links between the Wireless Devices and fixed networking Access Points. The major challenge of such solutions is the modeling of both the noise properties of the channel...... measurements and the user mobility patterns. One class of typical human being movement patterns is the segment-wise linear approach, which is studied in this paper. Current tracking solutions, such as the Constant Velocity model, hardly handle such segment-wise linear patterns. In this paper we propose...... a segment-wise linear model, called the Drifting Points model. The model results in an increased performance when compared with traditional solutions....

  5. Position, Energy, and Transit Time Distributions in a Hemispherical Deflector Analyzer with Position Sensitive Detector

    Directory of Open Access Journals (Sweden)

    Omer Sise

    2015-01-01

    Full Text Available Practical analytic equations, for the ideal field, and numerical results from SIMION simulations, for the fringing field, are presented for the exit radius rπ and transit time tπ of electrons in a hemispherical deflector analyzer (HDA over a wide range of analyzer parameters. Results are presented for a typically dimensioned HDA with mean radius R-=101.6 mm and interradial separation ΔR=R2-R1=58.4 mm able to accommodate a 40 mm diameter position sensitive detector (PSD. Results for three different entry positions R0 are compared: R0=R- (the conventional central entry and two displaced (paracentric entries: R0=82.55 mm and R0=116 mm. Exit spreads Δrπ, Δtπ and base energy resolution ΔEB are computed for HDA pass energies E0=10, 100, 500, and 1000 eV, entry aperture sizes Δr0≤1.5 mm, entry angular spreads |αmax|≤5°, and an electron beam with relative energy spread δE/E0≤0.4%. Overall, under realistic conditions, both paracentric entries demonstrate near ideal field behavior and clear superiority over the conventional entry at R0=R-. The R0=82.55 mm entry has better absolute energy and time spread resolutions, while the R0=116 mm has better relative energy resolutions, both offering attractive alternatives for time-of-flight and coincidence applications where both energy and timing resolutions are important.

  6. Approximation Theorems for q- Analouge of a Linear Positive Operator by A. Lupas

    Directory of Open Access Journals (Sweden)

    Karunesh Kumar Singh

    2016-08-01

    Full Text Available The purpose of the present paper is to introduce $q-$ analouge of a sequence of linear and positive operators which was introduced by A. Lupas [2]. First, we estimate moments of the operators and then prove a basic convergence theorem. Next, a local direct approximation theorem is established. Further, we study the rate of convergence and point-wise estimate using the Lipschitz type maximal function.

  7. The effect of mechanical stress on lateral-effect position-sensitive detector characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, H.A. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden)]. E-mail: Henrik.Andersson@miun.se; Mattsson, C.G. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden); Thungstroem, G. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden); Lundgren, A. [SiTek Electro Optics, Ogaerdesvaegen 13A 433 30 Partille (Sweden); Nilsson, H.-E. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden)

    2006-07-01

    Position-sensitive detectors (PSDs) are widely used in noncontact measurement systems. In order to minimize the size of such systems, interest has increased in mounting the PSD chip directly onto printed circuit boards (PCBs). Stress may be induced in the PSD because of the large differences in thermal expansion coefficients, as well as the long-term geometrical stability of the chip packaging. Mechanical stress has previously been shown to have an effect on the performance of semiconductors. The accuracy, or linearity, of a lateral effect PSD is largely dependent on the homogeneity of the resistive layer. Variations of the resistivity over the active area of the PSD will result in an uneven distribution of photo-generated current, and hence an error in the readout position. In this work experiments were performed to investigate the influence of anisotropic mechanical stress in terms of nonlinearity. PSD chips of 60x3 mm active area were subjected, respectively, to different amounts of compressive and tensile stress to determine the influence on the linearity.

  8. Asynchronous L1-gain control of uncertain switched positive linear systems with dwell time.

    Science.gov (United States)

    Li, Yang; Zhang, Hongbin

    2018-04-01

    In this paper, dwell time (DT) stability, L 1 -gain performance analysis and asynchronous L 1 -gain controller design problems of uncertain switched positive linear systems (SPLSs) are investigated. Via a time-scheduled multiple linear co-positive Lyapunov function (TSMLCLF) approach, convex sufficient conditions of DT stability and L 1 -gain performance of SPLSs with interval and polytopic uncertainties are presented. Furthermore, by utilizing the feature that the TSMLCLF keeps decreasing even if the controller is running asynchronously with the system, the asynchronous L 1 -gain controller design problem of SPLSs with interval and polytopic uncertainties is investigated. Convex sufficient conditions of the existence of time-varying asynchronous state-feedback controller which can ensure the closed-loop system's positivity, stability and L 1 -gain performance are established, and the controller gain matrices can be calculated instantaneously online. The obtained L 1 -gain in the paper is standard. All the results are presented in terms of linear programming. A practical example is provided to show the effectiveness of the results. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  9. Ventilatory sensitivity to mild asphyxia: prone versus supine sleep position

    OpenAIRE

    Galland, B; Bolton, D; Taylor, B; Sayers, R; Williams, S

    2000-01-01

    AIMS—To compare the effects of prone and supine sleep position on the main physiological responses to mild asphyxia: increase in ventilation and arousal.
METHODS—Ventilatory and arousal responses to mild asphyxia (hypercapnia/hypoxia) were measured in 53 healthy infants at newborn and 3 months of age, during quiet sleep (QS) and active sleep (AS), and in supine and prone sleep positions. The asphyxial test mimicked face down rebreathing by slowly altering the inspired air: C...

  10. Position sensitive proportional counters as focal plane detectors

    International Nuclear Information System (INIS)

    Ford, J.L.C. Jr.

    1979-01-01

    The rise time and charge division techniques for position decoding with RC-line proportional counters are reviewed. The advantages that these detectors offer as focal plane counters for nuclear spectroscopy performed with magnetic spectrographs are discussed. The theory of operation of proportional counters as position sensing devices is summarized, as well as practical aspects affecting their application. Factors limiting the position and energy resolutions obtainable with a focal plane proportional counter are evaluated and measured position and energy loss values are presented for comparison. Detector systems capable of the multiparameter measurements required for particle identification, background suppression and ray-tracing are described in order to illustrate the wide applicability of proportional counters within complex focal plane systems. Examples of the use of these counters other than with magnetic spectrographs are given in order to demonstrate their usefulness in not only nuclear physics but also in fields such as solid state physics, biology, and medicine. The influence of the new focal plane detector systems on future magnetic spectrograph designs is discussed. (Auth.)

  11. Motion sickness and otolith sensitivity - A pilot study of habituation to linear acceleration

    Science.gov (United States)

    Potvin, A. R.; Sadoff, M.; Billingham, J.

    1977-01-01

    Astronauts, particularly in Skylab flights, experienced varying degrees of motion sickness lasting 3-5 days. One possible mechanism for this motion sickness adaptation is believed to be a reduction in otolith sensitivity with an attendant reduction in sensory conflict. In an attempt to determine if this hypothesis is valid, a ground-based pilot study was conducted on a vertical linear accelerator. The extent of habituation to accelerations which initially produced motion sickness was evaluated, along with the possible value of habituation training to minimize the space motion sickness problem. Results showed that habituation occurred for 6 of the 8 subjects tested. However, in tests designed to measure dynamic and static otolith function, no significant differences between pre- and post-habituation tests were observed. Cross habituation effects to a standard Coriolis acceleration test were not significant. It is unlikely that ground-based pre-habituation to linear accelerations of the type examined would alter susceptibility to space motion sickness.

  12. Effects of socioeconomic position and social mobility on linear growth from early childhood until adolescence

    Directory of Open Access Journals (Sweden)

    Ana Paula Muraro

    Full Text Available ABSTRACT: Objective: To assess the effect of socioeconomic position (SEP in childhood and social mobility on linear growth through adolescence in a population-based cohort. Methods: Children born in Cuiabá-MT, central-western Brazil, were evaluated during 1994 - 1999. They were first assessed during 1999 - 2000 (0 - 5 years and again during 2009 - 2011 (10 - 17 years, and their height-for-age was evaluated during these two periods.Awealth index was used to classify the SEP of each child’s family as low, medium, or high. Social mobility was categorized as upward mobility or no upward mobility. Linear mixed models were used. Results: We evaluated 1,716 children (71.4% of baseline after 10 years, and 60.6% of the families showed upward mobility, with a higher percentage among the lowest economic classes. A higher height-for-age was also observed among those from families with a high SEP both in childhood (low SEP= -0.35 z-score; high SEP= 0.15 z-score, p < 0.01 and adolescence (low SEP= -0.01 z-score; high SEP= 0.45 z-score, p < 0.01, whereas upward mobility did not affect their linear growth. Conclusion: Expressive social mobility was observed, but SEP in childhood and social mobility did not greatly influence linear growth through childhood in this central-western Brazilian cohort.

  13. Gamma ray polarimetry using a position sensitive germanium detector

    CERN Document Server

    Kroeger, R A; Kurfess, J D; Phlips, B F

    1999-01-01

    Imaging gamma-ray detectors make sensitive polarimeters in the Compton energy regime by measuring the scatter direction of gamma rays. The principle is to capitalize on the angular dependence of the Compton scattering cross section to polarized gamma rays and measure the distribution of scatter directions within the detector. This technique is effective in a double-sided germanium detector between roughly 50 keV and 1 MeV. This paper reviews device characteristics important to the optimization of a Compton polarimeter, and summarizes measurements we have made using a device with a 5x5 cm active area, 1 cm thickness, and strip-electrodes on a 2 mm pitch.

  14. Solar receiver heliostat reflector having a linear drive and position information system

    Science.gov (United States)

    Horton, Richard H.

    1980-01-01

    A heliostat for a solar receiver system comprises an improved drive and control system for the heliostat reflector assembly. The heliostat reflector assembly is controllably driven in a predetermined way by a light-weight drive system so as to be angularly adjustable in both elevation and azimuth to track the sun and efficiently continuously reflect the sun's rays to a focal zone, i.e., heat receiver, which forms part of a solar energy utilization system, such as a solar energy fueled electrical power generation system. The improved drive system includes linear stepping motors which comprise low weight, low cost, electronic pulse driven components. One embodiment comprises linear stepping motors controlled by a programmed, electronic microprocessor. Another embodiment comprises a tape driven system controlled by a position control magnetic tape.

  15. Subcellular localization for Gram positive and Gram negative bacterial proteins using linear interpolation smoothing model.

    Science.gov (United States)

    Saini, Harsh; Raicar, Gaurav; Dehzangi, Abdollah; Lal, Sunil; Sharma, Alok

    2015-12-07

    Protein subcellular localization is an important topic in proteomics since it is related to a protein׳s overall function, helps in the understanding of metabolic pathways, and in drug design and discovery. In this paper, a basic approximation technique from natural language processing called the linear interpolation smoothing model is applied for predicting protein subcellular localizations. The proposed approach extracts features from syntactical information in protein sequences to build probabilistic profiles using dependency models, which are used in linear interpolation to determine how likely is a sequence to belong to a particular subcellular location. This technique builds a statistical model based on maximum likelihood. It is able to deal effectively with high dimensionality that hinders other traditional classifiers such as Support Vector Machines or k-Nearest Neighbours without sacrificing performance. This approach has been evaluated by predicting subcellular localizations of Gram positive and Gram negative bacterial proteins. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. An adaptive feedback controller for transverse angle and position jitter correction in linear particle beam accelerators

    International Nuclear Information System (INIS)

    Barr, D.S.

    1993-01-01

    It is desired to design a position and angle jitter control system for pulsed linear accelerators that will increase the accuracy of correction over that achieved by currently used standard feedback jitter control systems. Interpulse or pulse-to-pulse correction is performed using the average value of each macropulse. The configuration of such a system resembles that of a standard feedback correction system with the addition of an adaptive controller that dynamically adjusts the gain-phase contour of the feedback electronics. The adaptive controller makes changes to the analog feedback system between macropulses. A simulation of such a system using real measured jitter data from the Stanford Linear Collider was shown to decrease the average rms jitter by over two and a half times. The system also increased and stabilized the correction at high frequencies; a typical problem with standard feedback systems

  17. An adaptive feedback controller for transverse angle and position jitter correction in linear particle beam accelerators

    International Nuclear Information System (INIS)

    Barr, D.S.

    1992-01-01

    It is desired to design a position and angle jitter control system for pulsed linear accelerators that will increase the accuracy of correction over that achieved by currently used standard feedback jitter control systems. Interpulse or pulse-to-pulse correction is performed using the average value of each macropulse. The configuration of such a system resembles that of a standard feedback correction system with the addition of an adaptive controller that dynamically adjusts the gain-phase contour of the feedback electronics. The adaptive controller makes changes to the analog feedback system between macropulses. A simulation of such a system using real measured jitter data from the Stanford Linear Collider was shown to decrease the average rms jitter by over two and a half times. The system also increased and stabilized the correction at high frequencies; a typical problem with standard feedback systems

  18. Computer modelling of position-sensitive scintillator detectors

    International Nuclear Information System (INIS)

    Schelten, J.; Kurz, R.; Kernforschungsanlage Juelich G.m.b.H.

    1983-01-01

    The essential properties of a two-dimensional PSD consisting of 7 x 7 circular PMs of diameter D = 68 mm, optically coupled to a glass block disperser of thickness H, and of a thin glass scintillator which is optically decoupled from the disperser are analyzed by computer-simulation of the detector geometry which determines the light distribution on rows and columns of PMs for a neutron capture event and the electronic signal handling which leads to the response function Q(x,y). The computer simulations were performed in order to investigate geometrical variations, such as PMs with a square photo-cathode, a hexagonal arrangement, the effect of the disperser thickness and of conical condensers in front of the PMs and edge-effects due to the finite size of the disperser. The linearity of the detector can be optimised by adjusting three smoothing parameters S, S' and S''. These parameters can be introduced if the signal processing, which determines a neutron event, is based on a course selection of three PM columns and three rows followed by a weighted pulse height division for a final determination of the x and y coordinates. This paper briefly describes the simulations and presents the calculated results which refer closely to the two-dimensional PSD which is being built in the Laboratory. (author)

  19. Recent improvements to RC-line encoded position-sensitive proportional counters

    International Nuclear Information System (INIS)

    Borkowski, C.J.; Kopp, M.K.

    1977-01-01

    Continuing research on the principles of position encoding with RC lines has advanced the design of position-sensitive proportional counters (PSPCs) to meet the requirements for high count rates (>10 5 counts/sec) and good spatial resolution (>10 4 spatial elements) in small-angle scattering experiments with x rays and neutrons. Low-noise preamplifiers were developed with pole-zero cancellation in the feedback circuit and modular linear amplifiers with passive RCL shaping which, compared to previous designs, reduce output saturation at high count rates approx.20 times and shorten the position signal processing time to 2 ) for low-energy ( 800 x 800 mm 2 ) for the measurement of small-angle scattering with neutrons. The method of electronic thickness discrimination was applied to change the effective thickness of an area PSPC from 12 to 2 cm whenever the molybdenum target of an x-ray generator was changed to a copper target. This thickness adjustment increased the signal-to-background ratio by a factor of approx.6 for the 8-keV photons from the copper target, while maintaining a >90% detection efficiency

  20. Position and out-of-straightness measurement of a precision linear air-bearing stage by using a two-degree-of-freedom linear encoder

    International Nuclear Information System (INIS)

    Kimura, Akihide; Gao, Wei; Lijiang, Zeng

    2010-01-01

    This paper presents measurement of the X-directional position and the Z-directional out-of-straightness of a precision linear air-bearing stage with a two-degree-of-freedom (two-DOF) linear encoder, which is an optical displacement sensor for simultaneous measurement of the two-DOF displacements. The two-DOF linear encoder is composed of a reflective-type one-axis scale grating and an optical sensor head. A reference grating is placed perpendicular to the scale grating in the optical sensor head. Two-DOF displacements can be obtained from interference signals generated by the ±1 order diffracted beams from two gratings. A prototype two-DOF linear encoder employing the scale grating with the grating period of approximately 1.67 µm measured the X-directional position and the Z-directional out-of-straightness of the linear air-bearing stage

  1. Comparison of BiLinearly Interpolated Subpixel Sensitivity Mapping and Pixel-Level Decorrelation

    Science.gov (United States)

    Challener, Ryan C.; Harrington, Joseph; Cubillos, Patricio; Foster, Andrew S.; Deming, Drake; WASP Consortium

    2016-10-01

    Exoplanet eclipse signals are weaker than the systematics present in the Spitzer Space Telescope's Infrared Array Camera (IRAC), and thus the correction method can significantly impact a measurement. BiLinearly Interpolated Subpixel Sensitivity (BLISS) mapping calculates the sensitivity of the detector on a subpixel grid and corrects the photometry for any sensitivity variations. Pixel-Level Decorrelation (PLD) removes the sensitivity variations by considering the relative intensities of the pixels around the source. We applied both methods to WASP-29b, a Saturn-sized planet with a mass of 0.24 ± 0.02 Jupiter masses and a radius of 0.84 ± 0.06 Jupiter radii, which we observed during eclipse twice with the 3.6 µm and once with the 4.5 µm channels of IRAC aboard Spitzer in 2010 and 2011 (programs 60003 and 70084, respectively). We compared the results of BLISS and PLD, and comment on each method's ability to remove time-correlated noise. WASP-29b exhibits a strong detection at 3.6 µm and no detection at 4.5 µm. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  2. Low-sensitivity H ∞ filter design for linear delta operator systems with sampling time jitter

    Science.gov (United States)

    Guo, Xiang-Gui; Yang, Guang-Hong

    2012-04-01

    This article is concerned with the problem of designing H ∞ filters for a class of linear discrete-time systems with low-sensitivity to sampling time jitter via delta operator approach. Delta-domain model is used to avoid the inherent numerical ill-condition resulting from the use of the standard shift-domain model at high sampling rates. Based on projection lemma in combination with the descriptor system approach often used to solve problems related to delay, a novel bounded real lemma with three slack variables for delta operator systems is presented. A sensitivity approach based on this novel lemma is proposed to mitigate the effects of sampling time jitter on system performance. Then, the problem of designing a low-sensitivity filter can be reduced to a convex optimisation problem. An important consideration in the design of correlation filters is the optimal trade-off between the standard H ∞ criterion and the sensitivity of the transfer function with respect to sampling time jitter. Finally, a numerical example demonstrating the validity of the proposed design method is given.

  3. Plastic scintillators utilization in position sensitive detection systems

    International Nuclear Information System (INIS)

    Garcia, Marcelo Bernardes; Soares, Adalberto Jose; Baptista Filho, Benedito Dias

    2002-01-01

    This paper shows the viability of using a plastic scintillator detector to determine the one dimension position of a radioactive source. The experiments were performed using collimated 99m Tc sources of several activities supplied by the Centro de Radiofarmacia (from IPEN), and a 15 cm long plastic scintillator with diameter 5,08 cm, produced by the Centro de Tecnologia das Radiacoes (also from IPEN). The spectrum was obtained using the Genie 2000 software, and the results processed using a neural network specially developed for the proposed application. The final results demonstrate the viability of the proposed application. (author)

  4. Sliding-Mode Observer for Speed and Position Sensorless Control of Linear-PMSM

    Directory of Open Access Journals (Sweden)

    Kazraji Saeed Masoumi

    2014-05-01

    Full Text Available The paper presents a sliding-mode observer that utilizes sigmoid function for speed and position sensorless control of permanent-magnet linear synchronous motor (PMLSM. In conventional sliding mode observer method there are the chattering phenomenon and the phase lag. Thus, in order to avoid the usage of the low pass filter and the phase compensator based on back EMF, in this paper a sliding mode observer with sigmoid function for detecting the back EMF in a PMLSM is designed to estimate the speed and the position of the rotor. Most of conventional sliding mode observers use sign or saturation functions which need low pass filter in order to detect back electromotive force (back EMF. In this paper a sigmoid function is used instead of discontinuous sign function to decrease undesirable chattering phenomenon. By reducing the chattering, detecting of the back EMF can be made directly from switching signal without any low pass filter. Thus the delay time in the proposed observer is eliminated because of the low pass filter. Furthermore, there is no need to compensate phase fault in position and speed estimating of linear-PMSM. Advantages of the proposed observer have been shown by simulation with MATLAB software.

  5. Characterization and linear array LA48 Commissioner for measuring the position of the multi leaf collimator

    International Nuclear Information System (INIS)

    Conles Picos, I.; Cenizo de Castro, E.; Aparicio martin, A. R.; Barrio Lazo, F.; Cesteros Morante, M. J.

    2011-01-01

    The protocol of Quality Control of electron accelerators for medical use of SEFM proposed for multi leaf collimation system (MLC) to verify the positioning of the blades connect. To do this you must find a system with sufficient accuracy and precision and, if possible, easy to assemble and offers real-time results. One of these teams is the Linear Array of PTW-Freiburg (LA48), which consists of a row of 47 ionization chambers, of 0008 cc and 8 mm apart from each other. In this paper, we describe our process of characterization and LA48 commissioner. (Author)

  6. Minimum Energy Control of 2D Positive Continuous-Discrete Linear Systems

    Directory of Open Access Journals (Sweden)

    Kaczorek Tadeusz

    2014-09-01

    Full Text Available The minimum energy control problem for the 2D positive continuous-discrete linear systems is formulated and solved. Necessary and sufficient conditions for the reachability at the point of the systems are given. Sufficient conditions for the existence of solution to the problem are established. It is shown that if the system is reachable then there exists an optimal input that steers the state from zero boundary conditions to given final state and minimizing the performance index for only one step (q = 1. A procedure for solving of the problem is proposed and illustrated by a numerical example.

  7. The development of an algebraic multigrid algorithm for symmetric positive definite linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Vanek, P.; Mandel, J.; Brezina, M. [Univ. of Colorado, Denver, CO (United States)

    1996-12-31

    An algebraic multigrid algorithm for symmetric, positive definite linear systems is developed based on the concept of prolongation by smoothed aggregation. Coarse levels are generated automatically. We present a set of requirements motivated heuristically by a convergence theory. The algorithm then attempts to satisfy the requirements. Input to the method are the coefficient matrix and zero energy modes, which are determined from nodal coordinates and knowledge of the differential equation. Efficiency of the resulting algorithm is demonstrated by computational results on real world problems from solid elasticity, plate blending, and shells.

  8. Sensitivity Analysis of Linear Programming and Quadratic Programming Algorithms for Control Allocation

    Science.gov (United States)

    Frost, Susan A.; Bodson, Marc; Acosta, Diana M.

    2009-01-01

    The Next Generation (NextGen) transport aircraft configurations being investigated as part of the NASA Aeronautics Subsonic Fixed Wing Project have more control surfaces, or control effectors, than existing transport aircraft configurations. Conventional flight control is achieved through two symmetric elevators, two antisymmetric ailerons, and a rudder. The five effectors, reduced to three command variables, produce moments along the three main axes of the aircraft and enable the pilot to control the attitude and flight path of the aircraft. The NextGen aircraft will have additional redundant control effectors to control the three moments, creating a situation where the aircraft is over-actuated and where a simple relationship does not exist anymore between the required effector deflections and the desired moments. NextGen flight controllers will incorporate control allocation algorithms to determine the optimal effector commands and attain the desired moments, taking into account the effector limits. Approaches to solving the problem using linear programming and quadratic programming algorithms have been proposed and tested. It is of great interest to understand their relative advantages and disadvantages and how design parameters may affect their properties. In this paper, we investigate the sensitivity of the effector commands with respect to the desired moments and show on some examples that the solutions provided using the l2 norm of quadratic programming are less sensitive than those using the l1 norm of linear programming.

  9. A Monolithic CMOS Magnetic Hall Sensor with High Sensitivity and Linearity Characteristics

    Directory of Open Access Journals (Sweden)

    Haiyun Huang

    2015-10-01

    Full Text Available This paper presents a fully integrated linear Hall sensor by means of 0.8 μm high voltage complementary metal-oxide semiconductor (CMOS technology. This monolithic Hall sensor chip features a highly sensitive horizontal switched Hall plate and an efficient signal conditioner using dynamic offset cancellation technique. An improved cross-like Hall plate achieves high magnetic sensitivity and low offset. A new spinning current modulator stabilizes the quiescent output voltage and improves the reliability of the signal conditioner. The tested results show that at the 5 V supply voltage, the maximum Hall output voltage of the monolithic Hall sensor microsystem, is up to ±2.1 V and the linearity of Hall output voltage is higher than 99% in the magnetic flux density range from ±5 mT to ±175 mT. The output equivalent residual offset is 0.48 mT and the static power consumption is 20 mW.

  10. Cellular automaton-based position sensitive detector equalization

    Energy Technology Data Exchange (ETDEWEB)

    Ferrando, Nestor [Grupo de Diseno de Sistemas Digitales, Instituto de Aplicaciones de las Tecnologias de la Informacion y de las Comunicaciones Avanzadas, Universidad Politecnica de Valencia, Camino de Vera s/n, 46022 Valencia (Spain)], E-mail: nesferjo@upvnet.upv.es; Herrero, V.; Cerda, J.; Lerche, C.W.; Colom, R.J.; Gadea, R.; Martinez, J.D.; Monzo, J.M.; Mateo, F.; Sebastia, A.; Benlloch, J.M. [Grupo de Diseno de Sistemas Digitales, Instituto de Aplicaciones de las Tecnologias de la Informacion y de las Comunicaciones Avanzadas, Universidad Politecnica de Valencia, Camino de Vera s/n, 46022 Valencia (Spain)

    2009-06-01

    Indirect position detectors based on scintillator crystals lack of spacial uniformity in their response. This happens due to crystal inhomogeneities and gain differences among the photomultiplier anodes. In order to solve this, PESIC, an integrated front-end for multianode photomultiplier based nuclear imaging devices was created. One of its main features is the digitally programmable gain adjustment for every photomultiplier output. On another front, cellular automata have been proved to be a useful method for dynamic system modeling. In this paper, a cellular automaton which emulates the behavior of the scintillator crystal, the photomultiplier and the front-end is introduced. Thanks to this model, an automatic energy-based calibration of the detector can be done by configuring the cellular automaton with experimental data and making it evolve up to an stable state. This can be useful as a precalibration method of the detector.

  11. Three-dimensional, position-sensitive radiation detection

    Science.gov (United States)

    He, Zhong; Zhang, Feng

    2010-04-06

    Disclosed herein is a method of determining a characteristic of radiation detected by a radiation detector via a multiple-pixel event having a plurality of radiation interactions. The method includes determining a cathode-to-anode signal ratio for a selected interaction of the plurality of radiation interactions based on electron drift time data for the selected interaction, and determining the radiation characteristic for the multiple-pixel event based on both the cathode-to-anode signal ratio and the electron drift time data. In some embodiments, the method further includes determining a correction factor for the radiation characteristic based on an interaction depth of the plurality of radiation interactions, a lateral distance between the selected interaction and a further interaction of the plurality of radiation interactions, and the lateral positioning of the plurality of radiation interactions.

  12. 1-D position sensitive single carrier semiconductor detectors

    International Nuclear Information System (INIS)

    Zhong He; Knoll, G.F.; Wehe, D.K.; Rojeski, R.; Mastrangelo, C.H.; Hammig, M.; Barrett, C.; Uritani, A.

    1996-01-01

    A single polarity charge sensing method has been studied using coplanar electrodes on 5 mm cubes of CdZnTe γ-ray detectors. This method can ameliorate the hole trapping problem of room-temperature semiconductor detectors. Our experimental results confirm that the energy resolution is dramatically improved compared with that obtained using the conventional readout method, but is still about an order of magnitude worse than the theoretical limit. A method to obtain the γ-ray interaction depth between the cathode and the anode is presented here. This technique could be used to correct for the electron trapping as a function of distance from the coplanar electrodes. Experimental results showed that a position resolution of about 0.9 mm FWHM at 122 keV can be obtained. These results will be of interest in the design of higher performance room-temperature semiconductor γ-ray detectors. (orig.)

  13. Cellular automaton-based position sensitive detector equalization

    International Nuclear Information System (INIS)

    Ferrando, Nestor; Herrero, V.; Cerda, J.; Lerche, C.W.; Colom, R.J.; Gadea, R.; Martinez, J.D.; Monzo, J.M.; Mateo, F.; Sebastia, A.; Benlloch, J.M.

    2009-01-01

    Indirect position detectors based on scintillator crystals lack of spacial uniformity in their response. This happens due to crystal inhomogeneities and gain differences among the photomultiplier anodes. In order to solve this, PESIC, an integrated front-end for multianode photomultiplier based nuclear imaging devices was created. One of its main features is the digitally programmable gain adjustment for every photomultiplier output. On another front, cellular automata have been proved to be a useful method for dynamic system modeling. In this paper, a cellular automaton which emulates the behavior of the scintillator crystal, the photomultiplier and the front-end is introduced. Thanks to this model, an automatic energy-based calibration of the detector can be done by configuring the cellular automaton with experimental data and making it evolve up to an stable state. This can be useful as a precalibration method of the detector.

  14. 2D position sensitive microstrip sensors with charge division along the strip Studies on the position measurement error

    CERN Document Server

    Bassignana, D; Fernandez, M; Jaramillo, R; Lozano, M; Munoz, F.J; Pellegrini, G; Quirion, D; Vila, I; Vitorero, F

    2013-01-01

    Position sensitivity in semiconductor detectors of ionizing radiation is usually achieved by the segmentation of the sensing diode junction in many small sensing elements read out separately as in the case of conventional microstrips and pixel detectors. Alternatively, position sensitivity can be obtained by splitting the ionization signal collected by one single electrode amongst more than one readout channel with the ratio of the collected charges depending on the position where the signal was primary generated. Following this later approach, we implemented the charge division method in a conventional microstrip detector to obtain position sensitivity along the strip. We manufactured a proofof-concept demonstrator where the conventional aluminum electrodes were replaced by slightly resistive electrodes made of strongly doped poly-crystalline silicon and being readout at both strip ends. Here, we partially summarize the laser characterization of this first proof-of-concept demonstrator with special emphasis ...

  15. The Validity and Reliability of the Gymaware Linear Position Transducer for Measuring Counter-Movement Jump Performance in Female Athletes

    Science.gov (United States)

    O'Donnell, Shannon; Tavares, Francisco; McMaster, Daniel; Chambers, Samuel; Driller, Matthew

    2018-01-01

    The current study aimed to assess the validity and test-retest reliability of a linear position transducer when compared to a force plate through a counter-movement jump in female participants. Twenty-seven female recreational athletes (19 ± 2 years) performed three counter-movement jumps simultaneously using the linear position transducer and…

  16. Characterization of the order relation on the set of completely n-positive linear maps between C*-algebras

    Directory of Open Access Journals (Sweden)

    Maria Joita

    2007-12-01

    Full Text Available In this paper we characterize the order relation on the set of all nondegenerate completely n-positive linear maps between C*-algebras in terms of a self-dual Hilbert module induced by each completely n-positive linear map.

  17. Influence of a high vacuum on the precise positioning using an ultrasonic linear motor.

    Science.gov (United States)

    Kim, Wan-Soo; Lee, Dong-Jin; Lee, Sun-Kyu

    2011-01-01

    This paper presents an investigation of the ultrasonic linear motor stage for use in a high vacuum environment. The slider table is driven by the hybrid bolt-clamped Langevin-type ultrasonic linear motor, which is excited with its different modes of natural frequencies in both lateral and longitudinal directions. In general, the friction behavior in a vacuum environment becomes different from that in an environment of atmospheric pressure and this difference significantly affects the performance of the ultrasonic linear motor. In this paper, to consistently provide stable and high power of output in a high vacuum, frequency matching was conducted. Moreover, to achieve the fine control performance in the vacuum environment, a modified nominal characteristic trajectory following control method was adopted. Finally, the stage was operated under high vacuum condition, and the operating performances were investigated compared with that of a conventional PI compensator. As a result, robustness of positioning was accomplished in a high vacuum condition with nanometer-level accuracy.

  18. Influence of a high vacuum on the precise positioning using an ultrasonic linear motor

    International Nuclear Information System (INIS)

    Kim, Wan-Soo; Lee, Dong-Jin; Lee, Sun-Kyu

    2011-01-01

    This paper presents an investigation of the ultrasonic linear motor stage for use in a high vacuum environment. The slider table is driven by the hybrid bolt-clamped Langevin-type ultrasonic linear motor, which is excited with its different modes of natural frequencies in both lateral and longitudinal directions. In general, the friction behavior in a vacuum environment becomes different from that in an environment of atmospheric pressure and this difference significantly affects the performance of the ultrasonic linear motor. In this paper, to consistently provide stable and high power of output in a high vacuum, frequency matching was conducted. Moreover, to achieve the fine control performance in the vacuum environment, a modified nominal characteristic trajectory following control method was adopted. Finally, the stage was operated under high vacuum condition, and the operating performances were investigated compared with that of a conventional PI compensator. As a result, robustness of positioning was accomplished in a high vacuum condition with nanometer-level accuracy.

  19. Effects of socioeconomic position and social mobility on linear growth from early childhood until adolescence.

    Science.gov (United States)

    Muraro, Ana Paula; Souza, Rita Adriana Gomes de; Rodrigues, Paulo Rogério Melo; Ferreira, Márcia Gonçalves; Sichieri, Rosely

    2017-01-01

    To assess the effect of socioeconomic position (SEP) in childhood and social mobility on linear growth through adolescence in a population-based cohort. Children born in Cuiabá-MT, central-western Brazil, were evaluated during 1994 - 1999. They were first assessed during 1999 - 2000 (0 - 5 years) and again during 2009 - 2011 (10 - 17 years), and their height-for-age was evaluated during these two periods.Awealth index was used to classify the SEP of each child's family as low, medium, or high. Social mobility was categorized as upward mobility or no upward mobility. Linear mixed models were used. We evaluated 1,716 children (71.4% of baseline) after 10 years, and 60.6% of the families showed upward mobility, with a higher percentage among the lowest economic classes. A higher height-for-age was also observed among those from families with a high SEP both in childhood (low SEP= -0.35 z-score; high SEP= 0.15 z-score, p childhood and social mobility did not greatly influence linear growth through childhood in this central-western Brazilian cohort.

  20. Linear chemically sensitive electron tomography using DualEELS and dictionary-based compressed sensing

    Energy Technology Data Exchange (ETDEWEB)

    AlAfeef, Ala, E-mail: a.al-afeef.1@research.gla.ac.uk [SUPA School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); School of Computing Science, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Bobynko, Joanna [SUPA School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Cockshott, W. Paul. [School of Computing Science, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Craven, Alan J. [SUPA School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Zuazo, Ian; Barges, Patrick [ArcelorMittal Maizières Research, Maizières-lès-Metz 57283 (France); MacLaren, Ian, E-mail: ian.maclaren@glasgow.ac.uk [SUPA School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom)

    2016-11-15

    We have investigated the use of DualEELS in elementally sensitive tilt series tomography in the scanning transmission electron microscope. A procedure is implemented using deconvolution to remove the effects of multiple scattering, followed by normalisation by the zero loss peak intensity. This is performed to produce a signal that is linearly dependent on the projected density of the element in each pixel. This method is compared with one that does not include deconvolution (although normalisation by the zero loss peak intensity is still performed). Additionally, we compare the 3D reconstruction using a new compressed sensing algorithm, DLET, with the well-established SIRT algorithm. VC precipitates, which are extracted from a steel on a carbon replica, are used in this study. It is found that the use of this linear signal results in a very even density throughout the precipitates. However, when deconvolution is omitted, a slight density reduction is observed in the cores of the precipitates (a so-called cupping artefact). Additionally, it is clearly demonstrated that the 3D morphology is much better reproduced using the DLET algorithm, with very little elongation in the missing wedge direction. It is therefore concluded that reliable elementally sensitive tilt tomography using EELS requires the appropriate use of DualEELS together with a suitable reconstruction algorithm, such as the compressed sensing based reconstruction algorithm used here, to make the best use of the limited data volume and signal to noise inherent in core-loss EELS. - Highlights: • DualEELS is essential for chemically sensitive electron tomography using EELS. • A new compressed sensing based algorithm (DLET) gives high fidelity reconstruction. • This combination of DualEELS and DLET will give reliable results from few projections.

  1. A 3D Printed Linear Pneumatic Actuator for Position, Force and Impedance Control

    Directory of Open Access Journals (Sweden)

    Jeremy Krause

    2018-05-01

    Full Text Available Although 3D printing has the potential to provide greater customization and to reduce the costs of creating actuators for industrial applications, the 3D printing of actuators is still a relatively new concept. We have developed a pneumatic actuator with 3D-printed parts and placed sensors for position and force control. So far, 3D printing has been used to create pneumatic actuators of the bellows type, thus having a limited travel distance, utilizing low pressures for actuation and being capable of only limited force production and response rates. In contrast, our actuator is linear with a large travel distance and operating at a relatively higher pressure, thus providing great forces and response rates, and this the main novelty of the work. We demonstrate solutions to key challenges that arise during the design and fabrication of 3D-printed linear actuators. These include: (1 the strategic use of metallic parts in high stress areas (i.e., the piston rod; (2 post-processing of the inner surface of the cylinder for smooth finish; (3 piston head design and seal placement for strong and leak-proof action; and (4 sensor choice and placement for position and force control. A permanent magnet placed in the piston head is detected using Hall effect sensors placed along the length of the cylinder to measure the position, and pressure sensors placed at the supply ports were used for force measurement. We demonstrate the actuator performing position, force and impedance control. Our work has the potential to open new avenues for creating less expensive, customizable and capable actuators for industrial and other applications.

  2. A two-dimensional low energy gamma-ray position sensitive detector

    International Nuclear Information System (INIS)

    Charalambous, P.M.; Dean, A.J.; Drane, M.; Gil, A.; Stephen, J.B.; Young, N.G.S.; Barbareschi, L.; Perotti, F.; Villa, G.; Badiali, M.; La Padula, C.; Polcaro, F.; Ubertini, P.

    1984-01-01

    An array of 1-dimensional position sensitive detectors designed to operate over the photon energy range 0.2-10.0 MeV, so as to form an efficient 2-dimensional position sensitive detection plane is described. A series of experimental tests has been carried out to evaluate and confirm the computed capabilities. (orig.)

  3. Development of an ultrasonic linear motor with ultra-positioning capability and four driving feet.

    Science.gov (United States)

    Zhu, Cong; Chu, Xiangcheng; Yuan, Songmei; Zhong, Zuojin; Zhao, Yanqiang; Gao, Shuning

    2016-12-01

    This paper presents a novel linear piezoelectric motor which is suitable for rapid ultra-precision positioning. The finite element analysis (FEA) was applied for optimal design and further analysis, then experiments were conducted to investigate its performance. By changing the input signal, the proposed motor was found capable of working in the fast driving mode as well as in the precision positioning mode. When working in the fast driving mode, the motor acts as an ultrasonic motor with maximum no-load speed up to 181.2mm/s and maximum thrust of 1.7N at 200Vp-p. Also, when working in precision positioning mode, the motor can be regarded as a flexible hinge piezoelectric actuator with arbitrary motion in the range of 8μm. The measurable minimum output displacement was found to be 0.08μm, but theoretically, can be even smaller. More importantly, the motor can be quickly and accurately positioned in a large stroke. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. A position-sensitive scintillation detector for two-dimensional angular correlation of annihilation radiation using metal-package position-sensitive photomultiplier tubes

    International Nuclear Information System (INIS)

    Inoue, Koji; Nagai, Yasuyoshi; Saito, Haruo; Nagashima, Yasuyuki; Hyodo, Toshio; Muramatsu, Shinichi; Nagai, Shota

    1999-01-01

    We have constructed and tested a prototype of a new position sensitive γ-ray detector which consists of an array of 2.6x2.6x18 mm 3 BGO scintillator blocks, a light guide, and four metal-package position-sensitive photomultiplier tubes (R5900-00-C8) recently developed by Hamamatsu Photonics Co. Ltd. Scalability of the detector of this type makes it possible to construct a larger detector using many PS-PMTs, which will be useful for the two-dimensional angular correlation of annihilation radiation apparatus

  5. The AOLI Non-Linear Curvature Wavefront Sensor: High sensitivity reconstruction for low-order AO

    Science.gov (United States)

    Crass, Jonathan; King, David; Mackay, Craig

    2013-12-01

    Many adaptive optics (AO) systems in use today require bright reference objects to determine the effects of atmospheric distortions on incoming wavefronts. This requirement is because Shack Hartmann wavefront sensors (SHWFS) distribute incoming light from reference objects into a large number of sub-apertures. Bright natural reference objects occur infrequently across the sky leading to the use of laser guide stars which add complexity to wavefront measurement systems. The non-linear curvature wavefront sensor as described by Guyon et al. has been shown to offer a significant increase in sensitivity when compared to a SHWFS. This facilitates much greater sky coverage using natural guide stars alone. This paper describes the current status of the non-linear curvature wavefront sensor being developed as part of an adaptive optics system for the Adaptive Optics Lucky Imager (AOLI) project. The sensor comprises two photon-counting EMCCD detectors from E2V Technologies, recording intensity at four near-pupil planes. These images are used with a reconstruction algorithm to determine the phase correction to be applied by an ALPAO 241-element deformable mirror. The overall system is intended to provide low-order correction for a Lucky Imaging based multi CCD imaging camera. We present the current optical design of the instrument including methods to minimise inherent optical effects, principally chromaticity. Wavefront reconstruction methods are discussed and strategies for their optimisation to run at the required real-time speeds are introduced. Finally, we discuss laboratory work with a demonstrator setup of the system.

  6. Markov Jump Linear Systems-Based Position Estimation for Lower Limb Exoskeletons

    Directory of Open Access Journals (Sweden)

    Samuel L. Nogueira

    2014-01-01

    Full Text Available In this paper, we deal with Markov Jump Linear Systems-based filtering applied to robotic rehabilitation. The angular positions of an impedance-controlled exoskeleton, designed to help stroke and spinal cord injured patients during walking rehabilitation, are estimated. Standard position estimate approaches adopt Kalman filters (KF to improve the performance of inertial measurement units (IMUs based on individual link configurations. Consequently, for a multi-body system, like a lower limb exoskeleton, the inertial measurements of one link (e.g., the shank are not taken into account in other link position estimation (e.g., the foot. In this paper, we propose a collective modeling of all inertial sensors attached to the exoskeleton, combining them in a Markovian estimation model in order to get the best information from each sensor. In order to demonstrate the effectiveness of our approach, simulation results regarding a set of human footsteps, with four IMUs and three encoders attached to the lower limb exoskeleton, are presented. A comparative study between the Markovian estimation system and the standard one is performed considering a wide range of parametric uncertainties.

  7. Use of Opioid Medications for Employees in Critical Safety or Security Positions and Positions with Safety Sensitive Duties

    Science.gov (United States)

    2017-01-30

    can cause harm) to the physical well-being of or jeopardize the security of the employee , co-workers, customers or the general public through a lapse...DEPARTMENT OF THE ARMY US ARMY PUBLIC HEALTH CENTER 5158 BLACKHAWK ROAD ABERDEEN PROVING GROUND MARYLAND 21010-5403 Directorate of Clinical... Employees in Critical Safety or Security Positions and Positions with Safety Sensitive Duties. 1. REFERENCES. A. Army Regulation 40-5, Preventive

  8. Linear Analytical Solutions of Mechanical Sensitivity in Large Deflection of Unsymmetrically Layered Piezoelectric Plate under Pretension

    Directory of Open Access Journals (Sweden)

    Chun-Fu Chen

    2014-03-01

    Full Text Available Linear analytical study on the mechanical sensitivity in large deflection of unsymmetrically layered and laterally loaded piezoelectric plate under pretension is conducted. von Karman plate theory for large deflection is utilized but extended to the case of an unsymmetrically layered plate embedded with a piezoelectric layer. The governing equations thus obtained are simplified by omitting the arising nonlinear terms, yielding a Bessel or modified Bessel equation for the lateral slope. Depending on the relative magnitude of the piezoelectric effect, for both cases, analytical solutions of various geometrical responses are developed and formulated via Bessel and modified Bessel functions. The associated ultimate radial stresses are further derived following lamina constitutive law to evaluate the mechanical sensitivity of the considered plate. For a nearly monolithic plate under a very low applied voltage, the results are in good agreement with those for a single-layered case due to pure mechanical load available in literature, and thus the present approach is checked. For a two-layered unsymmetric plate made of typical silicon-based materials, a sound piezoelectric effect is illustrated particularly in a low pretension condition.

  9. Prototype of high resolution PET using resistive electrode position sensitive CdTe detectors

    International Nuclear Information System (INIS)

    Kikuchi, Yohei; Ishii, Keizo; Matsuyama, Shigeo; Yamazaki, Hiromichi

    2008-01-01

    Downsizing detector elements makes it possible that spatial resolutions of positron emission tomography (PET) cameras are improved very much. From this point of view, semiconductor detectors are preferable. To obtain high resolution, the pixel type or the multi strip type of semiconductor detectors can be used. However, in this case, there is a low packing ratio problem, because a dead area between detector arrays cannot be neglected. Here, we propose the use of position sensitive semiconductor detectors with resistive electrode. The CdTe detector is promising as a detector for PET camera because of its high sensitivity. In this paper, we report development of prototype of high resolution PET using resistive electrode position sensitive CdTe detectors. We made 1-dimensional position sensitive CdTe detectors experimentally by changing the electrode thickness. We obtained 750 A as an appropriate thickness of position sensitive detectors, and evaluated the performance of the detector using a collimated 241 Am source. A good position resolution of 1.2 mm full width half maximum (FWHM) was obtained. On the basis of the fundamental development of resistive electrode position sensitive detectors, we constructed a prototype of high resolution PET which was a dual head type and was consisted of thirty-two 1-dimensional position sensitive detectors. In conclusion, we obtained high resolutions which are 0.75 mm (FWHM) in transaxial, and 1.5 mm (FWHM) in axial. (author)

  10. Two-dimensional position sensitive silicon photodiode as a charged particle detector

    International Nuclear Information System (INIS)

    Kovacevic, K.; Zadro, M.

    1999-01-01

    A two-dimensional position sensitive silicon photodiode has been tested for measurement of position and energy of charged particles. Position nonlinearity and resolution, as well as energy resolution and ballistic deficit were measured for 5.486 MeV α-particles. The results obtained for different pulse shaping time constants are presented

  11. A position-sensitive start detector for time-of-flight measurement

    International Nuclear Information System (INIS)

    Ikezoe, Hiroshi; Shikazono, Naomoto; Isoyama, Goro.

    1978-08-01

    A position-sensitive start detector for a time-of-flight measurement is described. In this detector microchannel plates were used to obtain time and position signals simultaneously. A time resolution of 121 psec FWHM and a position resolution of 0.28 mm FWHM were obtained for α-particles from an 241 Am source. (auth.)

  12. POSSuMUS: a position sensitive scintillating muon SiPM detector

    CERN Document Server

    Ruschke, Alexander

    The development of a modular designed large scale scintillation detector with a two-dimensional position sensitivity is presented in this thesis. This novel POsition Sensitive Scintillating MUon SiPM Detector is named POSSuMUS. The POSSuMUS detector is capable to determine the particle’s position in two space dimensions with a fast trigger capability. Each module is constructed from two trapezoidal shaped plastic scintillators to form one rectangular shaped detector module. Both trapezoids are optically insulated against each other. In both trapezoids the scintillation light is collected by plastic fibers and guided towards silicon photomultipliers (SiPMs). SiPMs are light sensors which are capable to detect even smallest amounts of light. By combining several detector modules, position sensitive areas from 100 cm2 to few m2 are achievable with few readout channels. Therefore, POSSuMUS provides a cost effective detector concept. The position sensitivity along the trapezoidal geometry of one detector module ...

  13. The measurement of the radioactive aerosol diameter by position sensitive detectors, 3

    International Nuclear Information System (INIS)

    Murakami, Hiroyuki; Nakamoto, Atsushi; Kanamori, Masashi; Seki, Akio.

    1981-10-01

    The measurement of the diameter of radioactive aerosol, in particular plutonium aerosol, is very important for the internal dose estimation. Determination of the diameter of radioactive aerosol is performed by using the position sensitive detectors. Position sensitive semiconductor detectors and Scintillation detectors with IIT tube are used as the position sensitive detector. The filter paper with the radioactive aerosols is contacted to the PSD which is connected to the data processor so that the diameter of the aerosol is calculated from the measured radioactivity. (author)

  14. An Automated Magnet Positioning System For Use in the Next Linear Collider

    International Nuclear Information System (INIS)

    Viola, Robert J.

    2006-01-01

    The Next Linear Collider (NLC) is conceived as the world's most powerful electron-positron particle accelerator. Throughout the NLC, the beam itself will be used to measure errors in the positions of the lattice elements. This beam-based alignment strategy is an essential element of the NLC's design and precision adjustment systems have been identified as a critical enabling technology. Square One proposes a new type of precision manipulator that could be adapted for applications throughout the accelerator. As envisioned, this ''Tri-Sphere'' Adjustment System will possess up to six, non-redundant degrees of freedom, be capable of sub-micron resolutions and have ultimate load capacities in excess of 10,000 kg. The system will accommodate thermal expansions and contractions of the objects being supported and can be either motorized or manually actuated. Phase I development tasks will include detailed manipulator design, solution of the associated kinematic equations of motion and evaluation of actuators, gear reducers and transmission systems. The Phase I effort will culminate in the fabrication and full evaluation of a system prototype. A successfully developed Tri-Sphere manipulator could also be used to actively position critical fusion optics, adjust communication dishes or perform parts handling tasks in harsh manufacturing environments

  15. Filter Selection for Optimizing the Spectral Sensitivity of Broadband Multispectral Cameras Based on Maximum Linear Independence.

    Science.gov (United States)

    Li, Sui-Xian

    2018-05-07

    Previous research has shown that the effectiveness of selecting filter sets from among a large set of commercial broadband filters by a vector analysis method based on maximum linear independence (MLI). However, the traditional MLI approach is suboptimal due to the need to predefine the first filter of the selected filter set to be the maximum ℓ₂ norm among all available filters. An exhaustive imaging simulation with every single filter serving as the first filter is conducted to investigate the features of the most competent filter set. From the simulation, the characteristics of the most competent filter set are discovered. Besides minimization of the condition number, the geometric features of the best-performed filter set comprise a distinct transmittance peak along the wavelength axis of the first filter, a generally uniform distribution for the peaks of the filters and substantial overlaps of the transmittance curves of the adjacent filters. Therefore, the best-performed filter sets can be recognized intuitively by simple vector analysis and just a few experimental verifications. A practical two-step framework for selecting optimal filter set is recommended, which guarantees a significant enhancement of the performance of the systems. This work should be useful for optimizing the spectral sensitivity of broadband multispectral imaging sensors.

  16. Filter Selection for Optimizing the Spectral Sensitivity of Broadband Multispectral Cameras Based on Maximum Linear Independence

    Directory of Open Access Journals (Sweden)

    Sui-Xian Li

    2018-05-01

    Full Text Available Previous research has shown that the effectiveness of selecting filter sets from among a large set of commercial broadband filters by a vector analysis method based on maximum linear independence (MLI. However, the traditional MLI approach is suboptimal due to the need to predefine the first filter of the selected filter set to be the maximum ℓ2 norm among all available filters. An exhaustive imaging simulation with every single filter serving as the first filter is conducted to investigate the features of the most competent filter set. From the simulation, the characteristics of the most competent filter set are discovered. Besides minimization of the condition number, the geometric features of the best-performed filter set comprise a distinct transmittance peak along the wavelength axis of the first filter, a generally uniform distribution for the peaks of the filters and substantial overlaps of the transmittance curves of the adjacent filters. Therefore, the best-performed filter sets can be recognized intuitively by simple vector analysis and just a few experimental verifications. A practical two-step framework for selecting optimal filter set is recommended, which guarantees a significant enhancement of the performance of the systems. This work should be useful for optimizing the spectral sensitivity of broadband multispectral imaging sensors.

  17. A general technique for characterizing x-ray position sensitive arrays

    International Nuclear Information System (INIS)

    Dufresne, E.; Bruning, R.; Sutton, M.; Stephenson, G.B.

    1994-03-01

    We present a general statistical technique for characterizing x-ray sensitive linear diode arrays and CCD arrays. We apply this technique to characterize the response of a linear diode array, Princeton Instrument model X-PDA, and a virtual phase CCD array, TI 4849, to direct illumination by x-rays. We find that the response of the linear array is linearly proportional to the incident intensity and uniform over its length to within 2 %. Its quantum efficiency is 38 % for Cu K α x-rays. The resolution function is evaluated from the spatial autocorrelation function and falls to 10 % of its peak value after one pixel. On the other hand, the response of the CCD detecting system to direct x-ray exposure is non-linear. To properly quantify the scattered x-rays, one must correct for the non- linearity. The resolution is two pixels along the serial transfer direction. We characterize the noise of the CCD and propose a model that takes into account the non-linearity and the resolution function to estimate the quantum efficiency of the detector. The quantum efficiency is 20 %

  18. Hybrid organic/inorganic position-sensitive detectors based on PEDOT:PSS/n-Si

    Science.gov (United States)

    Javadi, Mohammad; Gholami, Mahdiyeh; Torbatiyan, Hadis; Abdi, Yaser

    2018-03-01

    Various configurations like p-n junctions, metal-semiconductor Schottky barriers, and metal-oxide-semiconductor structures have been widely used in position-sensitive detectors. In this report, we propose a PEDOT:PSS/n-Si heterojunction as a hybrid organic/inorganic configuration for position-sensitive detectors. The influence of the thickness of the PEDOT:PSS layer, the wavelength of incident light, and the intensity of illumination on the device performance are investigated. The hybrid PSD exhibits very high sensitivity (>100 mV/mm), excellent nonlinearity (0.995) with a response time of heterojunction are very promising for developing a new class of position-sensitive detectors based on the hybrid organic/inorganic junctions.

  19. A digital divider with extension bits for position-sensitive detectors

    International Nuclear Information System (INIS)

    Koike, Masaki; Hasegawa, Ken-ichi

    1988-01-01

    Digitizing errors produced in a digital divider for position-sensitive detectors have been reduced by adding extension bits to data bits. A relation between the extension bits and the data bits to obtain perfect position uniformity is also given. A digital divider employing 10 bit ADCs and 6 bit extension circuits has been constructed. (orig.)

  20. Positive solution of non-square fully Fuzzy linear system of equation in general form using least square method

    Directory of Open Access Journals (Sweden)

    Reza Ezzati

    2014-08-01

    Full Text Available In this paper, we propose the least square method for computing the positive solution of a non-square fully fuzzy linear system. To this end, we use Kaffman' arithmetic operations on fuzzy numbers \\cite{17}. Here, considered existence of exact solution using pseudoinverse, if they are not satisfy in positive solution condition, we will compute fuzzy vector core and then we will obtain right and left spreads of positive fuzzy vector by introducing constrained least squares problem. Using our proposed method, non-square fully fuzzy linear system of equations always has a solution. Finally, we illustrate the efficiency of proposed method by solving some numerical examples.

  1. Laser-engraved carbon nanotube paper for instilling high sensitivity, high stretchability, and high linearity in strain sensors

    KAUST Repository

    Xin, Yangyang

    2017-06-29

    There is an increasing demand for strain sensors with high sensitivity and high stretchability for new applications such as robotics or wearable electronics. However, for the available technologies, the sensitivity of the sensors varies widely. These sensors are also highly nonlinear, making reliable measurement challenging. Here we introduce a new family of sensors composed of a laser-engraved carbon nanotube paper embedded in an elastomer. A roll-to-roll pressing of these sensors activates a pre-defined fragmentation process, which results in a well-controlled, fragmented microstructure. Such sensors are reproducible and durable and can attain ultrahigh sensitivity and high stretchability (with a gauge factor of over 4.2 × 10(4) at 150% strain). Moreover, they can attain high linearity from 0% to 15% and from 22% to 150% strain. They are good candidates for stretchable electronic applications that require high sensitivity and linearity at large strains.

  2. Mehar Methods for Fuzzy Optimal Solution and Sensitivity Analysis of Fuzzy Linear Programming with Symmetric Trapezoidal Fuzzy Numbers

    Directory of Open Access Journals (Sweden)

    Sukhpreet Kaur Sidhu

    2014-01-01

    Full Text Available The drawbacks of the existing methods to obtain the fuzzy optimal solution of such linear programming problems, in which coefficients of the constraints are represented by real numbers and all the other parameters as well as variables are represented by symmetric trapezoidal fuzzy numbers, are pointed out, and to resolve these drawbacks, a new method (named as Mehar method is proposed for the same linear programming problems. Also, with the help of proposed Mehar method, a new method, much easy as compared to the existing methods, is proposed to deal with the sensitivity analysis of the same type of linear programming problems.

  3. Maternal sensitivity and latency to positive emotion following challenge: pathways through effortful control.

    Science.gov (United States)

    Conway, Anne; McDonough, Susan C; Mackenzie, Michael; Miller, Alison; Dayton, Carolyn; Rosenblum, Katherine; Muzik, Maria; Sameroff, Arnold

    2014-01-01

    The ability to self-generate positive emotions is an important component of emotion regulation. In this study, we focus on children's latency to express positive emotions following challenging situations and assess whether this ability operates through early maternal sensitivity and children's effortful control. Longitudinal relations between maternal sensitivity, infant negative affect, effortful control, and latency to positive emotion following challenge were examined in 156 children who were 33 months of age. Structural equation models supported the hypothesis that maternal sensitivity during infancy predicted better effortful control and, in turn, shorter latencies to positive emotions following challenge at 33 months. Directions for future research are discussed. © 2014 Michigan Association for Infant Mental Health.

  4. Pixel-Level Decorrelation and BiLinearly Interpolated Subpixel Sensitivity applied to WASP-29b

    Science.gov (United States)

    Challener, Ryan; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Deming, Drake

    2017-10-01

    Measured exoplanet transit and eclipse depths can vary significantly depending on the methodology used, especially at the low S/N levels in Spitzer eclipses. BiLinearly Interpolated Subpixel Sensitivity (BLISS) models a physical, spatial effect, which is independent of any astrophysical effects. Pixel-Level Decorrelation (PLD) uses the relative variations in pixels near the target to correct for flux variations due to telescope motion. PLD is being widely applied to all Spitzer data without a thorough understanding of its behavior. It is a mathematical method derived from a Taylor expansion, and many of its parameters do not have a physical basis. PLD also relies heavily on binning the data to remove short time-scale variations, which can artifically smooth the data. We applied both methods to 4 eclipse observations of WASP-29b, a Saturn-sized planet, which was observed twice with the 3.6 µm and twice with the 4.5 µm channels of Spitzer's IRAC in 2010, 2011 and 2014 (programs 60003, 70084, and 10054, respectively). We compare the resulting eclipse depths and midpoints from each model, assess each method's ability to remove correlated noise, and discuss how to choose or combine the best data analysis methods. We also refined the orbit from eclipse timings, detecting a significant nonzero eccentricity, and we used our Bayesian Atmospheric Radiative Transfer (BART) code to retrieve the planet's atmosphere, which is consistent with a blackbody. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  5. POSSuMUS. A position sensitive scintillating muon SiPM detector

    International Nuclear Information System (INIS)

    Ruschke, Alexander

    2014-01-01

    The development of a modular designed large scale scintillation detector with a two-dimensional position sensitivity is presented in this thesis. This novel POsition Sensitive Scintillating MUon SiPM Detector is named POSSuMUS. The POSSuMUS detector is capable to determine the particle's position in two space dimensions with a fast trigger capability. Each module is constructed from two trapezoidal shaped plastic scintillators to form one rectangular shaped detector module. Both trapezoids are optically insulated against each other. In both trapezoids the scintillation light is collected by plastic fibers and guided towards silicon photomultipliers (SiPMs). SiPMs are light sensors which are capable to detect even smallest amounts of light. By combining several detector modules, position sensitive areas from 100 cm 2 to few m 2 are achievable with few readout channels. Therefore, POSSuMUS provides a cost effective detector concept. The position sensitivity along the trapezoidal geometry of one detector module is achieved by the path length dependent amount of detected light for crossing particles. The ratio of the light yields in both trapezoids is calculated. This value corresponds to the position of the particle traversing the detector. A spatial resolution in the order of several mm is foreseen. The position sensitivity along the scintillator module is determined by the propagation time of light to the SiPMs located on opposite sides of the detector. A spatial resolution of few cm is expected for this direction. The POSSuMUS detector is applicable as large area trigger detector with a two dimensional position information of crossing particles. This is suitable in detector tests of large area precesion detectors or for measuring the small angle scattering of cosmic muons. At the beginning of this thesis, the determination of important SiPM characteristics like the breakdown voltage is presented. In the course of this work the detector principle is proven by

  6. Position-Sensitive Detector with Depth-of-Interaction Determination for Small Animal PET

    CERN Document Server

    Fedorov, A; Kholmetsky, A L; Korzhik, M V; Lecoq, P; Lobko, A S; Missevitch, O V; Tkatchev, A

    2002-01-01

    Crystal arrays made of LSO and LuAP crystals 2x2x10 mm pixels were manufactured for evaluation of detector with depth-of-interaction (DOI) determination capability intended for small animal positron emission tomograph. Position-sensitive LSO/LuAP phoswich DOI detector based on crystal 8x8 arrays and HAMAMATSU R5900-00-M64 position-sensitive multi-anode photomultiplier tube was developed and evaluated. Time resolution was found to be not worse than 1.0 ns FWHM for both layers, and spatial resolution mean value was 1.5 mm FWHM for the center of field-of-view.

  7. Development of 2D-ACAR apparatus using position-sensitive photomultiplier tubes

    Energy Technology Data Exchange (ETDEWEB)

    Nagai, Yasuyoshi; Saito, Haruo; Iwata, Tetsuya; Nagashima, Yasuyuki; Hyodo, Toshio [Tokyo Univ. (Japan). Coll. of Arts and Sciences; Uchida, Hiroshi; Omura, Tomohide

    1997-03-01

    A new two-dimensional angular correlation of annihilation radiation apparatus is described. Position-sensitive photomultiplier tubes coupled with two-dimensional arrays of small BGO scintillator blocks make simple and compact position-sensitive {gamma}-ray detectors. With a sample-detector distance of 5m, an angular resolution of 1.1 mrad FWHM and a coincidence count rate of {approx}2.4 c.p.s. per mCi are obtained. Its performance is demonstrated by the result of a test measurement for KI crystal in which non-localized positronium exists at low temperatures. (author)

  8. Kalman filter with a linear state model for PDR+WLAN positioning and its application to assisting a particle filter

    Science.gov (United States)

    Raitoharju, Matti; Nurminen, Henri; Piché, Robert

    2015-12-01

    Indoor positioning based on wireless local area network (WLAN) signals is often enhanced using pedestrian dead reckoning (PDR) based on an inertial measurement unit. The state evolution model in PDR is usually nonlinear. We present a new linear state evolution model for PDR. In simulated-data and real-data tests of tightly coupled WLAN-PDR positioning, the positioning accuracy with this linear model is better than with the traditional models when the initial heading is not known, which is a common situation. The proposed method is computationally light and is also suitable for smoothing. Furthermore, we present modifications to WLAN positioning based on Gaussian coverage areas and show how a Kalman filter using the proposed model can be used for integrity monitoring and (re)initialization of a particle filter.

  9. A high count rate one-dimensional position sensitive detector and a data acquisition system for time resolved X-ray scattering studies

    International Nuclear Information System (INIS)

    Pernot, P.

    1982-01-01

    A curved multiwire proportional drift chamber has been built as a general purpose instrument for X-ray scattering and X-ray diffraction experiments with synchrotron radiation. This parallaxe-free one-dimensional linear position sensitive detector has a parallel readout with a double hit logic. The data acquisition system, installed as a part of the D11 camera at LURE-DCI, is designed to perform time slicing and cyclic experiments; it has been used with either the fast multiwire chamber or a standard position sensitive detector with delay line readout [fr

  10. Performance of high-resolution position-sensitive detectors developed for storage-ring decay experiments

    International Nuclear Information System (INIS)

    Yamaguchi, T.; Suzaki, F.; Izumikawa, T.; Miyazawa, S.; Morimoto, K.; Suzuki, T.; Tokanai, F.; Furuki, H.; Ichihashi, N.; Ichikawa, C.; Kitagawa, A.; Kuboki, T.; Momota, S.; Nagae, D.; Nagashima, M.; Nakamura, Y.; Nishikiori, R.; Niwa, T.; Ohtsubo, T.; Ozawa, A.

    2013-01-01

    Highlights: • Position-sensitive detectors were developed for storage-ring decay spectroscopy. • Fiber scintillation and silicon strip detectors were tested with heavy ion beams. • A new fiber scintillation detector showed an excellent position resolution. • Position and energy detection by silicon strip detectors enable full identification. -- Abstract: As next generation spectroscopic tools, heavy-ion cooler storage rings will be a unique application of highly charged RI beam experiments. Decay spectroscopy of highly charged rare isotopes provides us important information relevant to the stellar conditions, such as for the s- and r-process nucleosynthesis. In-ring decay products of highly charged RI will be momentum-analyzed and reach a position-sensitive detector set-up located outside of the storage orbit. To realize such in-ring decay experiments, we have developed and tested two types of high-resolution position-sensitive detectors: silicon strips and scintillating fibers. The beam test experiments resulted in excellent position resolutions for both detectors, which will be available for future storage-ring experiments

  11. A position sensitive parallel plate avalanche fission detector for use in particle induced fission coincidence measurements

    NARCIS (Netherlands)

    Plicht, J. van der

    1980-01-01

    A parallel plate avalanche detector developed for the detection of fission fragments in particle induced fission reactions is described. The active area is 6 × 10 cm2; it is position sensitive in one dimension with a resolution of 2.5 mm. The detector can withstand a count rate of 25000 fission

  12. Face Inversion Disproportionately Disrupts Sensitivity to Vertical over Horizontal Changes in Eye Position

    Science.gov (United States)

    Crookes, Kate; Hayward, William G.

    2012-01-01

    Presenting a face inverted (upside down) disrupts perceptual sensitivity to the spacing between the features. Recently, it has been shown that this disruption is greater for vertical than horizontal changes in eye position. One explanation for this effect proposed that inversion disrupts the processing of long-range (e.g., eye-to-mouth distance)…

  13. Sensitivity Analyses of Alternative Methods for Disposition of High-Level Salt Waste: A Position Statement

    International Nuclear Information System (INIS)

    Harris, S.P.; Tuckfield, R.C.

    1998-01-01

    This position paper provides the approach and detail pertaining to a sensitivity analysis for the Phase II definition of weighted evaluation criteria weights and utility function values on the total utility scores for each Initial List alternative due to uncertainty and bias in engineering judgment

  14. Method and apparatus for formation logging using position sensitive neutron detectors

    International Nuclear Information System (INIS)

    Gadken, L.L.

    1986-01-01

    This patent describes a method for logging earth formations using position sensitive neutron detectors. The method consists of: 1) Irradiation of earth formations in the vicinity of a well borehole with a source of fast neutrons. 2) At four longitudinally spaced distances from the neutron source in the borehole, the epithermal neutron population is detected. Each of the four separate populations is detected in an epithermally sensitive and substantially thermally insensitive portion of the same position sensitive neutron detector. A representative signal from each is then individually generated. 3) First, second, third, and fourth neutron population representative signals are combined. They derive a simultaneous measurement signal. This signal is functionally related to the porosity and also a signal functionally related to a neutron characteristic length of the earth formations in the vicinity of the borehole

  15. Linear antenna of an arbitrary orientation and position in cylindric screen

    International Nuclear Information System (INIS)

    Prijmenko, S.D.; Papkovich, V.G.; Khizhnyak, N.A.

    1991-01-01

    An equation of the linear antenna in cylindric screen is formulated. Using the averaging method a solution of this equation for the antenna of arbitrary orientation which does not contact the screen walls or contacts them in one or two ends is received. The obtained asymptotic expression for stream permits to describe in a single manner the case of resonance and non-resonance scattering. These results may be applied in design of UHF and accelerating installations using cylindric screens charged with linear vibrators. 9 refs. (author)

  16. A new technique for extracting the red edge position from hyperspectral data : the linear extrapolation method

    NARCIS (Netherlands)

    Cho, M.A.; Skidmore, A.K.

    2006-01-01

    There is increasing interest in using hyperspectral data for quantitative characterization of vegetation in spatial and temporal scopes. Many spectral indices are being developed to improve vegetation sensitivity by minimizing the background influence. The chlorophyll absorption continuum index

  17. The design of a position-sensitive thermal-neutron detector

    International Nuclear Information System (INIS)

    Zhang Yi; Chen Ziyu; Shen Ji

    2007-01-01

    We design a type of position-sensitive thermal-neutron detector. The design is based on the nuclear reaction 10 B(n, α) 7 Li, and solid boron-10 is used as the target material while the alpha and lithium-7 particles from the reaction are caught as the source of position information of the original neutrons. With the help of MCNP software, we simulate the distribution of alpha particles in the boron target, which leads to the optimal thickness of target, physical efficiency and position resolution. (authors)

  18. Tests of crossed-wire position sensitive photomultipliers for scintillating fiber particle tracking

    International Nuclear Information System (INIS)

    Perdrisat, C.F.; Koechner, D.; Majewski, S.; Pourang, R.; Wilson, C.D.; Zorn, C.

    1995-01-01

    Several applications of two Hamamatsu position sensitive photomultiplier tubes to the detection of high energy particles with scintillating fibers are discussed. The PMTs are of the multiwire anode grid design, type R2486 and R4135. These tubes were tested with both single samples and arrays of 2 and 3 mm diameter scintillating fibers. Measurements of position resolution of the PMTs using either the charge digitization or the delay line readout techniques were made. The results indicate an intrinsic inability of the technique to reconstruct the actual position of a fiber on the photocathode when its location falls halfway between two grid wires. A way to overcome this limit is suggested. (orig.)

  19. Bayesian linear regression : different conjugate models and their (in)sensitivity to prior-data conflict

    NARCIS (Netherlands)

    Walter, G.M.; Augustin, Th.; Kneib, Thomas; Tutz, Gerhard

    2010-01-01

    The paper is concerned with Bayesian analysis under prior-data conflict, i.e. the situation when observed data are rather unexpected under the prior (and the sample size is not large enough to eliminate the influence of the prior). Two approaches for Bayesian linear regression modeling based on

  20. Sensitivity of the Positive and Negative Syndrome Scale (PANSS) in Detecting Treatment Effects via Network Analysis.

    Science.gov (United States)

    Esfahlani, Farnaz Zamani; Sayama, Hiroki; Visser, Katherine Frost; Strauss, Gregory P

    2017-12-01

    Objective: The Positive and Negative Syndrome Scale is a primary outcome measure in clinical trials examining the efficacy of antipsychotic medications. Although the Positive and Negative Syndrome Scale has demonstrated sensitivity as a measure of treatment change in studies using traditional univariate statistical approaches, its sensitivity to detecting network-level changes in dynamic relationships among symptoms has yet to be demonstrated using more sophisticated multivariate analyses. In the current study, we examined the sensitivity of the Positive and Negative Syndrome Scale to detecting antipsychotic treatment effects as revealed through network analysis. Design: Participants included 1,049 individuals diagnosed with psychotic disorders from the Phase I portion of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. Of these participants, 733 were clinically determined to be treatment-responsive and 316 were found to be treatment-resistant. Item level data from the Positive and Negative Syndrome Scale were submitted to network analysis, and macroscopic, mesoscopic, and microscopic network properties were evaluated for the treatment-responsive and treatment-resistant groups at baseline and post-phase I antipsychotic treatment. Results: Network analysis indicated that treatment-responsive patients had more densely connected symptom networks after antipsychotic treatment than did treatment-responsive patients at baseline, and that symptom centralities increased following treatment. In contrast, symptom networks of treatment-resistant patients behaved more randomly before and after treatment. Conclusions: These results suggest that the Positive and Negative Syndrome Scale is sensitive to detecting treatment effects as revealed through network analysis. Its findings also provide compelling new evidence that strongly interconnected symptom networks confer an overall greater probability of treatment responsiveness in patients with

  1. Positioning of the rf potential minimum line of a linear Paul trap with micrometer precision

    DEFF Research Database (Denmark)

    Herskind, Peter Fønss; Dantan, Aurélien; Albert, Magnus

    2009-01-01

    We demonstrate a general technique to achieve a precise radial displacement of the nodal line of the radiofrequency (rf) field in a linear Paul trap. The technique relies on the selective adjustment of the load capacitance of the trap electrodes, achieved through the addition of capacitors...... to the basic resonant rf circuit used to drive the trap. Displacements of up to ~100 µm with micrometer precision are measured using a combination of fluorescence images of ion Coulomb crystals and coherent coupling of such crystals to a mode of an optical cavity. The displacements are made without measurable...

  2. A multi-component nanocomposite screen-printed ink with non-linear touch sensitive electrical conductivity

    International Nuclear Information System (INIS)

    Webb, Alexander J; Szablewski, Marek; Bloor, David; Atkinson, Del; Graham, Adam; Laughlin, Paul; Lussey, David

    2013-01-01

    Printable electronics is an innovative area of technology with great commercial potential. Here, a screen-printed functional ink, comprising a combination of semiconducting acicular particles, electrically insulating nanoparticles and a base polymer ink, is described that exhibits pronounced pressure sensitive electrical properties for applications in sensing and touch sensitive surfaces. The combination of these components in the as-printed ink yield a complex structure and a large and reproducible touch pressure sensitive resistance range. In contrast to the case for some composite systems, the resistance changes occur down to applied pressures of 13 Pa. Current–voltage measurements at fixed pressures show monotonic non-linear behaviour, which becomes more Ohmic at higher pressures and in all cases shows some hysteresis. The physical basis for conduction, particularly in the low pressure regime, can be described in terms of field assisted quantum mechanical tunnelling. (paper)

  3. A multi-component nanocomposite screen-printed ink with non-linear touch sensitive electrical conductivity.

    Science.gov (United States)

    Webb, Alexander J; Szablewski, Marek; Bloor, David; Atkinson, Del; Graham, Adam; Laughlin, Paul; Lussey, David

    2013-04-26

    Printable electronics is an innovative area of technology with great commercial potential. Here, a screen-printed functional ink, comprising a combination of semiconducting acicular particles, electrically insulating nanoparticles and a base polymer ink, is described that exhibits pronounced pressure sensitive electrical properties for applications in sensing and touch sensitive surfaces. The combination of these components in the as-printed ink yield a complex structure and a large and reproducible touch pressure sensitive resistance range. In contrast to the case for some composite systems, the resistance changes occur down to applied pressures of 13 Pa. Current-voltage measurements at fixed pressures show monotonic non-linear behaviour, which becomes more Ohmic at higher pressures and in all cases shows some hysteresis. The physical basis for conduction, particularly in the low pressure regime, can be described in terms of field assisted quantum mechanical tunnelling.

  4. A multi-component nanocomposite screen-printed ink with non-linear touch sensitive electrical conductivity

    Science.gov (United States)

    Webb, Alexander J.; Szablewski, Marek; Bloor, David; Atkinson, Del; Graham, Adam; Laughlin, Paul; Lussey, David

    2013-04-01

    Printable electronics is an innovative area of technology with great commercial potential. Here, a screen-printed functional ink, comprising a combination of semiconducting acicular particles, electrically insulating nanoparticles and a base polymer ink, is described that exhibits pronounced pressure sensitive electrical properties for applications in sensing and touch sensitive surfaces. The combination of these components in the as-printed ink yield a complex structure and a large and reproducible touch pressure sensitive resistance range. In contrast to the case for some composite systems, the resistance changes occur down to applied pressures of 13 Pa. Current-voltage measurements at fixed pressures show monotonic non-linear behaviour, which becomes more Ohmic at higher pressures and in all cases shows some hysteresis. The physical basis for conduction, particularly in the low pressure regime, can be described in terms of field assisted quantum mechanical tunnelling.

  5. Ultrafast Readout of Scintillating Fibres Using Upgraded Position-Sensitive Photomultipliers

    CERN Multimedia

    2002-01-01

    % RD-17 \\\\ \\\\To design a high rate topological trigger device for the future DIRAC Experiment at CERN an extensive work is in progress on a scintillating-fibre detector using a position-sensitive photomultiplier. Several detector prototypes with different lengths ($<$~50~cm) of sensitive area have been tested at T7S~PS beam. \\\\ \\\\With 0.5~mm diameter fibres a spatial resolution of $\\sim$125~$\\mu$m was obtained with a detection efficiency higher than 95\\%. The time resolution is $\\sim$600~ps, and the track position is properly digitized in real time (about 10~ns) by multi-channel peak sensing circuit. Based on experimental data simulations were also performed a comparison of different types of front-end electronics for multi-channel readout.

  6. Cerium doped GSO scintillators and its application to position sensitive detectors

    International Nuclear Information System (INIS)

    Ishibashi, H.; Shimizu, K.; Susa, K.; Kubota, S.

    1989-01-01

    The dependence of the light output and the decay times of Ce doped Gd/sub 2/SiO/sub 5/ on Ce concentration is measured. By using the difference in decay times on Ce concentration for GSO(Ce), the combination of different concentration of GSO(Ce) scintillators is shown to be useful as position sensitive detectors. A Ce doped Gd/sub 2/SiO/sub 5/ (GSO(Ce)) single crystal is an excellent scintillator featuring, a large light output, a short decay time and a high absorption coefficient. Further investigation aimed at its implementation to scintillators has been carried out previously. An application of the GSO(Ce) scintillators to the gamma-ray detectors of positron emission computed tomography has also been shown. The authors have investigated the dependence of its scintillation properties on the Ce concentration and its application to position sensitive detectors

  7. Position sensitive proportional counter for measurement of tritium labelled gas movement

    International Nuclear Information System (INIS)

    Mori, Chizuo; Nakamoto, Makihiko; Uritani, Akira; Watanabe, Tamaki

    1984-01-01

    A position sensitive proportional counter of a charge division type with a single resistive anode wire was constructed for the measurement of the movement of 3 H labelled gas which is flowing or diffusing in a pipe. The introduction of resistors between the anode wire and pre-amplifiers brought a uniform detection efficiency for 3 H β-rays throughout the counter. The position resolution was 3.1 mm FWHM. Detection efficiency was almost 100% uniformly over about 700 mm in the total anode length of 740 mm. The movement of 3 H labelled gas could be measured effectively. (author)

  8. Coplanar-grid CdZnTe detector with three-dimensional position sensitivity

    International Nuclear Information System (INIS)

    Luke, P.N.; Amman, M.; Lee, J.S.; Yaver, H.

    1998-06-01

    A 3-dimensional position-sensitive coplanar-grid detector design for use with compound semiconductors is described. This detector design maintains the advantage of a coplanar-grid detector in which good energy resolution can be obtained from materials with poor charge transport. Position readout in two dimensions is accomplished using proximity-sensing electrodes adjacent to the electron-collecting grid electrode of the detector. Additionally, depth information is obtained by taking the ratio of the amplitudes of the collecting grid signal and the cathode signal. Experimental results from a prototype CdZnTe detector are presented

  9. High speed USB data logger for position sensitive detector data acquisition

    International Nuclear Information System (INIS)

    Poudel, S.K.; Kulkarni, V.B.; Kumar, Santosh; Chandak, R.M.; Krishna, P.S.R.; Mukhopadhyay, R.

    2010-01-01

    Ratio ADC (RDC) module used in neutron Position Sensitive Detector (PSD) data acquisition, gives digital code signifying the position of neutron event. A High Speed USB based RDC Data Logger card has been made for logging data from multiple RDCs to PC. A CPLD on the card continuously polls the RDCs for data, and fills it in the FIFO memory of a high speed USB microcontroller. A VC++ program for neutron scattering experiments reads event codes from FIFO of microcontroller and builds spectrum on PC. This program sweeps physical parameters of sample and collects PSD data for pre-determined monitor counts. (author)

  10. Linear rheology of cross-linked polypropylene oxide as a pressure sensitive adhesive

    DEFF Research Database (Denmark)

    Jensen, Mette Krog; Bach, A.; Hassager, Ole

    2009-01-01

    are carefully considered. Two main mechanisms must be considered when studying adhesives, that is the debonding and bonding mechanisms. Linear rheology is used to study the debonding mechanisms to gain better understanding of the peeling process of the PSAs. A variety of PSAs are prepared by mixing a linear......-linked networks. The adhesive performance was tested with 90 degrees peel tests at three peel rates and thicknesses, and it was observed that the peel force varies with r, M and f and also the peel rate. The fundamental viscoelastic parameters that govern the PSA performance of cross-linked systems were used...... to state an empirical relation for the peel force. The relation is combining the peel force with the loss tangent at the peel frequency and the equilibrium modulus. Based on this, basic guidelines for selecting the appropriate polymer/cross-linker system to achieve the target performance are given....

  11. Sensitivity Analysis of Multicarrier Digital Pre-distortion/ Equalization Techniques for Non-linear Satellite Channels

    OpenAIRE

    Piazza, Roberto; Shankar, Bhavani; Zenteno, Efrain; Ronnow, Daniel; Liolis, Kostantinos; Zimmer, Frank; Grasslin, Michael; Berheide, Tobias; Cioni, Stefano

    2013-01-01

    On-board joint power amplification of multiple-carrier DVB-S2 signals using a single High-Power Amplifier (HPA) is an emerging configuration that aims to reduce flight hardware and weight. However, effects specific to such a scenario degrade power and spectral efficiencies with increased Adjacent Channel Interference caused by non-linear characteristic of the HPA and power efficiency loss due to the increased Peak to Average Power Ratio (PAPR). The paper studies signal processing techniques ...

  12. A new position-sensitive detector for thermal and epithermal neutrons

    International Nuclear Information System (INIS)

    Jeavons, A.P.; Ford, N.L.; Lindberg, B.; Sachot, R.

    1977-01-01

    A new two-dimensional position-sensitive neutron detector is described. It is based on (n,γ) neutron resonance capture in a foil with subsequent detection of internal conversion electrons with a high-density proportional chamber. Large-area detectors with a 1 mm spatial resolution are feasible. A detection efficiency of 50% is possible for thermal neutrons using gadolinium-157 foil and for epithermal neutrons using hafnium-177. (Auth.)

  13. Angle-resolved ion TOF spectrometer with a position sensitive detector

    Energy Technology Data Exchange (ETDEWEB)

    Saito, Norio [Electrotechnical Lab., Tsukuba, Ibaraki (Japan); Heiser, F; Wieliczec, K; Becker, U

    1996-07-01

    A angle-resolved ion time-of-flight mass spectrometer with a position sensitive anode has been investigated. Performance of this spectrometer has been demonstrated by measuring an angular distribution of a fragment ion pair, C{sup +} + O{sup +}, from CO at the photon energy of 287.4 eV. The obtained angular distribution is very close to the theoretically expected one. (author)

  14. The local lymph node assay: current position in the regulatory classification of skin sensitizing chemicals.

    Science.gov (United States)

    Basketter, David A; Gerberick, G Frank; Kimber, Ian

    2007-01-01

    The local lymph node assay (LLNA) is being used increasingly in the identification of skin sensitizing chemicals for regulatory purposes. In the context of new chemicals legislation (REACH) in Europe, it is the preferred assay. The rationale for this is that the LLNA quantitative and objective approach to skin sensitization testing allied with the important animal welfare benefits that the method offers. However, as with certain guinea pig sensitization tests before it, this increasing use also brings experience with an increasingly wide range of industrial and other chemicals where the outcome of the assay does not always necessarily meet with the expectations of those conducting it. Sometimes, the result appears to be a false negative, but rather more commonly, the complaint is that the chemical represents a false positive. Against this background we have here reviewed a number of instances where false positive and false negative results have been described and have sought to reconcile science with expectation. Based on these analyses, it is our conclusion that false positives and false negatives do occur in the LLNA, as they do with any other skin sensitization assay (and indeed with all tests used for hazard identification), and that this occurs for a number of reasons. We further conclude, however, that false positive results in the LLNA, as with the guinea pig maximization test, arise most commonly via failure to distinguish what is scientifically correct from that which is unpalatable. The consequences of this confusion are discussed in the article, particularly in relation to the need to integrate both potency measurement and risk assessments into classification and labelling schemes that aim to manage potential risks to human health.

  15. Test of a position-sensitive photomultiplier for fast scintillating fiber detector read-out

    International Nuclear Information System (INIS)

    Baehr, J.; Hoffmann, B.; Luedecke, H.; Nahnhauer, R.; Pohl, M.; Roloff, H.E.

    1993-01-01

    A position-sensitive photomultiplier with 256 anode pixels has been used to read out scintillating fibers excited by light emitting diodes, electrons from a β-source and a 5 GeV electron beam. Measurements have been done within a magnetic field up to 0.6 T. Tracking and electromagnetic shower detection capabilities of a simple fiber detector have been studied. (orig.)

  16. On the consistency of adjoint sensitivity analysis for structural optimization of linear dynamic problems

    DEFF Research Database (Denmark)

    Jensen, Jakob Søndergaard; Nakshatrala, Praveen B.; Tortorelli, Daniel A.

    2014-01-01

    Gradient-based topology optimization typically involves thousands or millions of design variables. This makes efficient sensitivity analysis essential and for this the adjoint variable method (AVM) is indispensable. For transient problems it has been observed that the traditional AVM, based on a ...

  17. DIAGNOSIS OF CULTURE POSITIVE URINARY TRACT INFECTIONS AND THEIR ANTIMICROBIAL SENSITIVITY PROFILE IN TERTIARY CARE CENTRE

    Directory of Open Access Journals (Sweden)

    Prince Sreekumar Pius

    2016-12-01

    Full Text Available BACKGROUND Urinary tract infection is very common all over the world and in India more than 10 million cases are reported per year. It is one of the common infections diagnosed in the outpatients as well as the hospitalised patients. Empirical treatment of community acquired urinary tract infections are determined by the antibiotic sensitivity in a population. This study was conducted to determine the antimicrobial sensitivity amongst the uropathogens to help establish local guidelines on treatment of urinary tract infection. MATERIALS AND METHODS In this study, we collected 1306 samples from patients in whom we suspected to have urinary tract infection based on clinical signs and symptoms (e.g. with fever (greater than 38°C without another explanation or from a patient who had at least one urinary symptom (dysuria, urgency, frequency, or suprapubic pain or tenderness in our hospital during January 2016-June 2016. RESULTS Urine cultures were positive for 18% of the patients. Among these cultures, Klebsiella pneumonia (41%, Escherichia coli (35% and Pseudomonas aeruginosa (7% were the common organisms found. Highest antimicrobial sensitivity amongst these pathogens was found with cefoperazone/sulbactam and amikacin. CONCLUSION Cefoperazone/sulbactam and amikacin were the highly sensitive systemic antibiotics while ciprofloxacin and norfloxacin were the sensitive oral antibiotics in our locality.

  18. Range position and climate sensitivity: The structure of among-population demographic responses to climatic variation

    Science.gov (United States)

    Amburgey, Staci M.; Miller, David A. W.; Grant, Evan H. Campbell; Rittenhouse, Tracy A. G.; Benard, Michael F.; Richardson, Jonathan L.; Urban, Mark C.; Hughson, Ward; Brand, Adrianne B,; Davis, Christopher J.; Hardin, Carmen R.; Paton, Peter W. C.; Raithel, Christopher J.; Relyea, Rick A.; Scott, A. Floyd; Skelly, David K.; Skidds, Dennis E.; Smith, Charles K.; Werner, Earl E.

    2018-01-01

    Species’ distributions will respond to climate change based on the relationship between local demographic processes and climate and how this relationship varies based on range position. A rarely tested demographic prediction is that populations at the extremes of a species’ climate envelope (e.g., populations in areas with the highest mean annual temperature) will be most sensitive to local shifts in climate (i.e., warming). We tested this prediction using a dynamic species distribution model linking demographic rates to variation in temperature and precipitation for wood frogs (Lithobates sylvaticus) in North America. Using long-term monitoring data from 746 populations in 27 study areas, we determined how climatic variation affected population growth rates and how these relationships varied with respect to long-term climate. Some models supported the predicted pattern, with negative effects of extreme summer temperatures in hotter areas and positive effects on recruitment for summer water availability in drier areas. We also found evidence of interacting temperature and precipitation influencing population size, such as extreme heat having less of a negative effect in wetter areas. Other results were contrary to predictions, such as positive effects of summer water availability in wetter parts of the range and positive responses to winter warming especially in milder areas. In general, we found wood frogs were more sensitive to changes in temperature or temperature interacting with precipitation than to changes in precipitation alone. Our results suggest that sensitivity to changes in climate cannot be predicted simply by knowing locations within the species’ climate envelope. Many climate processes did not affect population growth rates in the predicted direction based on range position. Processes such as species-interactions, local adaptation, and interactions with the physical landscape likely affect the responses we observed. Our work highlights the

  19. A Linear Programming Approach to Routing Control in Networks of Constrained Nonlinear Positive Systems with Concave Flow Rates

    Science.gov (United States)

    Arneson, Heather M.; Dousse, Nicholas; Langbort, Cedric

    2014-01-01

    We consider control design for positive compartmental systems in which each compartment's outflow rate is described by a concave function of the amount of material in the compartment.We address the problem of determining the routing of material between compartments to satisfy time-varying state constraints while ensuring that material reaches its intended destination over a finite time horizon. We give sufficient conditions for the existence of a time-varying state-dependent routing strategy which ensures that the closed-loop system satisfies basic network properties of positivity, conservation and interconnection while ensuring that capacity constraints are satisfied, when possible, or adjusted if a solution cannot be found. These conditions are formulated as a linear programming problem. Instances of this linear programming problem can be solved iteratively to generate a solution to the finite horizon routing problem. Results are given for the application of this control design method to an example problem. Key words: linear programming; control of networks; positive systems; controller constraints and structure.

  20. Positive words or negative words: whose valence strength are we more sensitive to?

    Science.gov (United States)

    Yang, Jiemin; Zeng, Jing; Meng, Xianxin; Zhu, Liping; Yuan, Jiajin; Li, Hong; Yusoff, Nasir

    2013-10-02

    The present study investigates the human brains' sensitivity to the valence strength of emotionally positive and negative chinese words. Event-Related Potentials were recorded, in two different experimental sessions, for Highly Positive (HP), Mildly Positive (MP) and neutral (NP) words and for Highly Negative (HN), Mildly Negative (MN) and neutral (NN) words, while subjects were required to count the number of words, irrespective of word meanings. The results showed a significant emotion effect in brain potentials for both HP and MP words, and the emotion effect occurred faster for HP words than MP words: HP words elicited more negative deflections than NP words in N2 (250-350 ms) and P3 (350-500 ms) amplitudes, while MP words elicited a significant emotion effect in P3, but not in N2, amplitudes. By contrast, HN words elicited larger amplitudes than NN words in N2 but not in P3 amplitudes, whereas MN words produced no significant emotion effect across N2 and P3 components. Moreover, the size of emotion-neutral differences in P3 amplitudes was significantly larger for MP compared to MN words. Thus, the human brain is reactive to both highly and mildly positive words, and this reactivity increased with the positive valence strength of the words. Conversely, the brain is less reactive to the valence of negative relative to positive words. These results suggest that human brains are equipped with increased sensitivity to the valence strength of positive compared to negative words, a type of emotional stimuli that are well known for reduced arousal. © 2013 Elsevier B.V. All rights reserved.

  1. Accretion of Fat-Free Mass Rather Than Fat Mass in Infancy Is Positively Associated with Linear Growth in Childhood.

    Science.gov (United States)

    Admassu, Bitiya; Ritz, Christian; Wells, Jonathan C K; Girma, Tsinuel; Andersen, Gregers S; Belachew, Tefera; Owino, Victor; Michaelsen, Kim F; Abera, Mubarek; Wibaek, Rasmus; Friis, Henrik; Kæstel, Pernille

    2018-04-01

    We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied. This study examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children. In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized accretion rates were obtained by dividing FM and FFM accretion by their respective SD. FFM accretion from 0 to 6 mo of age was positively associated with length at 1 y (β = 0.64; 95% CI: 0.19, 1.09; P = 0.005) and linear growth from 1 to 5 y (β = 0.63; 95% CI: 0.19, 1.07; P = 0.005). The strongest association with FFM accretion was observed at 1 y. The association with linear growth from 1 to 5 y was mainly engendered by the 1-y association. FM accretion from 0 to 4 mo was positively associated with linear growth from 1 to 5 y (β = 0.45; 95% CI: 0.02, 0.88; P = 0.038) in the fully adjusted model. In Ethiopian children, FFM accretion was associated with linear growth at 1 y and no clear additional longitudinal effect from 1 to 5 y was observed. FM accretion showed a weak association from 1 to 5 y. This trial was registered at www.controlled-trials.com as ISRCTN46718296.

  2. SENSITIVITY ANALYSIS AND SHAPE OPTIMIZATION OF GEOMETRICALLY NON-LINEAR STRUCTURES

    OpenAIRE

    EVANDRO PARENTE JUNIOR

    2000-01-01

    Este trabalho propõe uma metodologia para a otimização de forma de estruturas geometricamente não-lineares. O objetivo desta metodologia é evitar os problemas de instabilidade apresentados por estruturas otimizadas de acordo com a formulação clássica. Ela foi implementada para problemas bidimensionais e os resultados obtidos na otimização de diferentes estruturas demonstraram o seu sucesso. Utilizando-se conceitos de modelagem geométrica, a forma da e...

  3. A fast large-area position-sensitive time-of-flight neutron detection system

    International Nuclear Information System (INIS)

    Crawford, R.K.; Haumann, J.R.

    1989-01-01

    A new position-sensitive time-of-flight neutron detection and histograming system has been developed for use at the Intense Pulsed Neutron Source. Spatial resolution of roughly 1 cm x 1 cm and time-of-flight resolution of ∼1 μsec are combined in a detection system which can ultimately be expanded to cover several square meters of active detector area. This system is based on the use of arrays of cylindrical one-dimensional position-sensitive proportional counters, and is capable of collecting the x-y-t data and sorting them into histograms at time-averaged data rates up to ∼300,000 events/sec over the full detector area and with instantaneous data rates up to more than fifty times that. Numerous hardware features have been incorporated to facilitate initial tuning of the position encoding, absolute calibration of the encoded positions, and automatic testing for drifts. 7 refs., 11 figs., 1 tabs

  4. Recent developments and applications of fast position-sensitive gas detectors

    International Nuclear Information System (INIS)

    Sauli, Fabio

    1999-01-01

    The introduction, 30 years ago, of the multiwire proportional chamber initiated a very active and fruitful period of development of fast gas detectors. Performing position-sensitive devices have been perfected, for the needs of elementary particle physics and for applications in medical diagnostics, biology, material analysis. The high rate performance of wire counters, limited by positive ions accumulation, was largely improved with the introduction of the micro-strip gas chamber, capable of achieving position accuracies of few tens of microns at radiation fluxes exceeding 1 MHz/mm 2 . The micro-strip chamber properties have been extensively studied in view of large scale use in high luminosity experiments; some interesting applications in other fields will be described here. Originally conceived as a gain booster to solve reliability problems met with micro-strips, the gas electron multiplier was invented about a year and a half ago. Progress made with high gain models is leading to a new concept in gas detectors, powerful yet cheap and reliable. Possible developments and applications will be discussed: large area position-sensitive photo detectors and X-ray imagers, including devices with non-planar geometry suited to spectrometers and crystal diffraction studies

  5. Head position in the MEG helmet affects the sensitivity to anterior sources.

    Science.gov (United States)

    Marinkovic, K; Cox, B; Reid, K; Halgren, E

    2004-11-30

    Current MEG instruments derive the whole-head coverage by utilizing a helmet-shaped opening at the bottom of the dewar. These helmets, however, are quite a bit larger than most people's heads so subjects commonly lean against the back wall of the helmet in order to maintain a steady position. In such cases the anterior brain sources may be too distant to be picked up by the sensors reliably. Potential "invisibility" of the frontal and anterior temporal sources may be particularly troublesome for the studies of cognition and language, as they are subserved significantly by these areas. We examined the sensitivity of the distributed anatomically-constrained MEG (aMEG) approach to the head position ("front" vs. "back") secured within a helmet with custom-tailored bite-bars during a lexical decision task. The anterior head position indeed resulted in much greater sensitivity to language-related activity in frontal and anterior temporal locations. These results emphasize the need to adjust the head position in the helmet in order to maximize the "visibility" of the sources in the anterior brain regions in cognitive and language tasks.

  6. Optoelectronic device for the measurement of the absolute linear position in the micrometric displacement range

    Science.gov (United States)

    Morlanes, Tomas; de la Pena, Jose L.; Sanchez-Brea, Luis M.; Alonso, Jose; Crespo, Daniel; Saez-Landete, Jose B.; Bernabeu, Eusebio

    2005-07-01

    In this work, an optoelectronic device that provides the absolute position of a measurement element with respect to a pattern scale upon switch-on is presented. That means that there is not a need to perform any kind of transversal displacement after the startup of the system. The optoelectronic device is based on the process of light propagation passing through a slit. A light source with a definite size guarantees the relation of distances between the different elements that constitute our system and allows getting a particular optical intensity profile that can be measured by an electronic post-processing device providing the absolute location of the system with a resolution of 1 micron. The accuracy of this measuring device is restricted to the same limitations of any incremental position optical encoder.

  7. Development of a contactless DC current sensor with high linearity and sensitivity based on the magnetoelectric effect

    Science.gov (United States)

    Castro, N.; Reis, S.; Silva, M. P.; Correia, V.; Lanceros-Mendez, S.; Martins, P.

    2018-06-01

    The magnetoelectric (ME) effect is increasingly being considered an attractive alternative for magnetic field and smart current sensing, being able to sense static and dynamic magnetic fields. This work reports on a contactless DC current sensor device based on a ME PVDF/Metglas composite, a solenoid and the corresponding electronic instrumentation. The ME sample shows a maximum resonant ME coefficient (α 33) of 34.48 V cm‑1 Oe‑1, a linear response (R 2 = 0.998) and a sensitivity of 6.7 mV A‑1. With the incorporation of a charge amplifier, an AC-RMS converter and a microcontroller the linearity is maintained (R 2 = 0.997), the ME output voltage increases to a maximum of 2320 mV and the sensitivity rises to 476.5 mV A‑1. Such features allied to the highest sensitivity reported in the literature on polymer-based ME composites provide to the reported ME sensing device suitable characteristics to be used in non-contact electric current measurement, motor operational status checking, and condition monitoring of rechargeable batteries, among others.

  8. The position dependent influence that sensitivity correction processing gives the signal-to-noise ratio measurement in parallel imaging

    International Nuclear Information System (INIS)

    Murakami, Koichi; Yoshida, Koji; Yanagimoto, Shinichi

    2012-01-01

    We studied the position dependent influence that sensitivity correction processing gave the signal-to-noise ratio (SNR) measurement of parallel imaging (PI). Sensitivity correction processing that referred to the sensitivity distribution of the body coil improved regional uniformity more than the sensitivity uniformity correction filter with a fixed correction factor. In addition, the position dependent influence to give the SNR measurement in PI was different from the sensitivity correction processing. Therefore, if we divide SNR of the sensitivity correction processing image by SNR of the original image in each pixel and calculate SNR ratio, we can show the position dependent influence that sensitivity correction processing gives the SNR measurement in PI. It is with an index of the sensitivity correction processing precision. (author)

  9. Improvements to a neutral radiation detection and position sensitive process and devices

    International Nuclear Information System (INIS)

    Charpak, Georges; Nguyen, N.H.; Policarpo, Armando.

    1977-01-01

    This invention aims to provide a neutral radiation position sensitive process and device providing a spatial radiation satisfactory for most medical applications and an energy radiation that cannot be reached by gas detectors based on proportional counters or by scintillation counters. Only solid state detectors can compete with respect to energy resolution. The detector described enables large areas to be covered which cannot be reached at accessible costs by solid state detectors. With this aim in view, the invention suggests an incident neutral radiation and position sensitive process, particularly soft gamma and X radiations, whereby photoelectrons are made to form by incident radiation action on gas atoms contained in an enclosure. By means of an electric field, the electrons are diverted towards a space undergoing an electric field high enough in value to create photons by exciting gas atoms and returning them to the de-excited state. The photons are collected, through a transparent window, on a layer of a material for converting such photons into scintillations in the near or visible UV spectrum and the barycentre of the scintillations is positioned on the layer, for instance by photomultipliers or ionization detectors. According to another aspect of the invention, it suggests a detection and position sensitive device comprising (generally downstream of a collimator with a grid of inlet holes) a leak tight containment fitted with an inlet window transparent to incident radiations, filled with a gas producing electrons by interaction with the incident radiation, and fitted with electrodes for generating an electric field to divert the electrons to a space for creating secondary photons [fr

  10. Sensitivity, Specificity, and Positivity Predictors of the Pneumococcal Urinary Antigen Test in Community-Acquired Pneumonia.

    Science.gov (United States)

    Molinos, Luis; Zalacain, Rafael; Menéndez, Rosario; Reyes, Soledad; Capelastegui, Alberto; Cillóniz, Catia; Rajas, Olga; Borderías, Luis; Martín-Villasclaras, Juan J; Bello, Salvador; Alfageme, Inmaculada; Rodríguez de Castro, Felipe; Rello, Jordi; Ruiz-Manzano, Juan; Gabarrús, Albert; Musher, Daniel M; Torres, Antoni

    2015-10-01

    Detection of the C-polysaccharide of Streptococcus pneumoniae in urine by an immune-chromatographic test is increasingly used to evaluate patients with community-acquired pneumonia. We assessed the sensitivity and specificity of this test in the largest series of cases to date and used logistic regression models to determine predictors of positivity in patients hospitalized with community-acquired pneumonia. We performed a multicenter, prospective, observational study of 4,374 patients hospitalized with community-acquired pneumonia. The urinary antigen test was done in 3,874 cases. Pneumococcal infection was diagnosed in 916 cases (21%); 653 (71%) of these cases were diagnosed exclusively by the urinary antigen test. Sensitivity and specificity were 60 and 99.7%, respectively. Predictors of urinary antigen positivity were female sex; heart rate≥125 bpm, systolic blood pressureantibiotic treatment; pleuritic chest pain; chills; pleural effusion; and blood urea nitrogen≥30 mg/dl. With at least six of all these predictors present, the probability of positivity was 52%. With only one factor present, the probability was only 12%. The urinary antigen test is a method with good sensitivity and excellent specificity in diagnosing pneumococcal pneumonia, and its use greatly increased the recognition of community-acquired pneumonia due to S. pneumoniae. With a specificity of 99.7%, this test could be used to direct simplified antibiotic therapy, thereby avoiding excess costs and risk for bacterial resistance that result from broad-spectrum antibiotics. We also identified predictors of positivity that could increase suspicion for pneumococcal infection or avoid the unnecessary use of this test.

  11. Non-linear elasticity of extracellular matrices enables contractile cells to communicate local position and orientation.

    Directory of Open Access Journals (Sweden)

    Jessamine P Winer

    2009-07-01

    Full Text Available Most tissue cells grown in sparse cultures on linearly elastic substrates typically display a small, round phenotype on soft substrates and become increasingly spread as the modulus of the substrate increases until their spread area reaches a maximum value. As cell density increases, individual cells retain the same stiffness-dependent differences unless they are very close or in molecular contact. On nonlinear strain-stiffening fibrin gels, the same cell types become maximally spread even when the low strain elastic modulus would predict a round morphology, and cells are influenced by the presence of neighbors hundreds of microns away. Time lapse microscopy reveals that fibroblasts and human mesenchymal stem cells on fibrin deform the substrate by several microns up to five cell lengths away from their plasma membrane through a force limited mechanism. Atomic force microscopy and rheology confirm that these strains locally and globally stiffen the gel, depending on cell density, and this effect leads to long distance cell-cell communication and alignment. Thus cells are acutely responsive to the nonlinear elasticity of their substrates and can manipulate this rheological property to induce patterning.

  12. Compton imaging with a highly-segmented, position-sensitive HPGe detector

    Energy Technology Data Exchange (ETDEWEB)

    Steinbach, T.; Hirsch, R.; Reiter, P.; Birkenbach, B.; Bruyneel, B.; Eberth, J.; Hess, H.; Lewandowski, L. [Universitaet zu Koeln, Institut fuer Kernphysik, Koeln (Germany); Gernhaeuser, R.; Maier, L.; Schlarb, M.; Weiler, B.; Winkel, M. [Technische Universitaet Muenchen, Physik Department, Garching (Germany)

    2017-02-15

    A Compton camera based on a highly-segmented high-purity germanium (HPGe) detector and a double-sided silicon-strip detector (DSSD) was developed, tested, and put into operation; the origin of γ radiation was determined successfully. The Compton camera is operated in two different modes. Coincidences from Compton-scattered γ-ray events between DSSD and HPGe detector allow for best angular resolution; while the high-efficiency mode takes advantage of the position sensitivity of the highly-segmented HPGe detector. In this mode the setup is sensitive to the whole 4π solid angle. The interaction-point positions in the 36-fold segmented large-volume HPGe detector are determined by pulse-shape analysis (PSA) of all HPGe detector signals. Imaging algorithms were developed for each mode and successfully implemented. The angular resolution sensitively depends on parameters such as geometry, selected multiplicity and interaction-point distances. Best results were obtained taking into account the crosstalk properties, the time alignment of the signals and the distance metric for the PSA for both operation modes. An angular resolution between 13.8 {sup circle} and 19.1 {sup circle}, depending on the minimal interaction-point distance for the high-efficiency mode at an energy of 1275 keV, was achieved. In the coincidence mode, an increased angular resolution of 4.6 {sup circle} was determined for the same γ-ray energy. (orig.)

  13. Towards red-edge positions less sensitive to canopy biophysical parameters for leaf chlorophyll estimation using properties optique spectrales des feuilles (PROSPECT) and scattering by arbitrarily inclined leaves (SAILH) simulated data

    NARCIS (Netherlands)

    Cho, M.A.; Skidmore, A.K.; Atzberger, C.

    2008-01-01

    Several methods for extracting the chlorophyll sensitive red-edge position (REP) from hyperspectral data are reported in literature. This study is a continuation of a recent paper published as 'A new technique for extracting the red edge position from hyperspectral data: the linear extrapolation

  14. A high sensitive 66 dB linear dynamic range receiver for 3-D laser radar

    Science.gov (United States)

    Ma, Rui; Zheng, Hao; Zhu, Zhangming

    2017-08-01

    This study presents a CMOS receiver chip realized in 0.18 μm standard CMOS technology and intended for high precision 3-D laser radar. The chip includes an adjustable gain transimpedance pre-amplifier, a post-amplifier and two timing comparators. An additional feedback is employed in the regulated cascode transimpedance amplifier to decrease the input impedance, and a variable gain transimpedance amplifier controlled by digital switches and analog multiplexer is utilized to realize four gain modes, extending the input dynamic range. The measurement shows that the highest transimpedance of the channel is 50 k {{Ω }}, the uncompensated walk error is 1.44 ns in a wide linear dynamic range of 66 dB (1:2000), and the input referred noise current is 2.3 pA/\\sqrt{{Hz}} (rms), resulting in a very low detectable input current of 1 μA with SNR = 5.

  15. Compact very low temperature scanning tunneling microscope with mechanically driven horizontal linear positioning stage.

    Science.gov (United States)

    Suderow, H; Guillamon, I; Vieira, S

    2011-03-01

    We describe a scanning tunneling microscope for operation in a dilution refrigerator with a sample stage which can be moved macroscopically in a range up to a cm and with an accuracy down to the tens of nm. The position of the tip over the sample as set at room temperature does not change more than a few micrometers when cooling down. This feature is particularly interesting for work on micrometer sized samples. Nanostructures can be also localized and studied, provided they are repeated over micrometer sized areas. The same stage can be used to approach a hard single crystalline sample to a knife and cleave it, or break it, in situ. In situ positioning is demonstrated with measurements at 0.1 K in nanofabricated samples. Atomic resolution down to 0.1 K and in magnetic fields of 8 T is demonstrated in NbSe(2). No heat dissipation nor an increase in mechanical noise has been observed at 0.1 K when operating the slider.

  16. A UV-prepared linear polymer electrolyte membrane for dye-sensitized solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Imperiyka, M., E-mail: imperiyka@gmail.com [Faculty of Arts and Sciences, Kufra Campus, University of Benghazi, Al Kufrah (Libya); Ahmad, A.; Hanifah, S.A. [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia); Polymer Research Center, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia); Bella, F. [Center for Space Human Robotics @Polito, Istituto Italiano di Tecnologia, Corso Trento 21, 10129 Torino (Italy); Department of Applied Science and Technology – DISAT, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino (Italy)

    2014-10-01

    The effects of LiClO{sub 4} and LiFS{sub 3}SO{sub 3} on poly(glycidyl methacrylate)-based solid polymer electrolyte and its photoelectrochemical performance in a dye sensitized solar cell consisting of FTO/TiO{sub 2}–dye/P(GMA)–LiClO{sub 4}–EC/Pt were investigated. The electrochemical stability of films was studied by cyclic voltammetry (CV). The highest ionic conductivities obtained were 4.2×10{sup −5} and 3.7×10{sup −6} S cm{sup −1} for the film containing 30 wt% LiClO{sub 4} and 25 wt% LiCF{sub 3}SO{sub 3}, respectively. The polymer electrolytes showed electrochemical stability windows up to 3 V and 2.8 V for LiClO{sub 4} and LiCF{sub 3}SO{sub 3}, respectively. The assembled dye-sensitized solar cell showed a sunlight conversion efficiency of 0.679% (J{sub sc}=3 mA cm{sup −2}, V{sub oc}=0.48 V and FF=0.47), under light intensity of 100 mW cm{sup −2}.

  17. About a Class of Positive Hybrid Dynamic Linear Systems and an Associate Extended Kalman-Yakubovich-Popov Lemma

    Directory of Open Access Journals (Sweden)

    M. De la Sen

    2017-01-01

    Full Text Available This paper formulates an “ad hoc” robust version under parametrical disturbances of the discrete version of the Kalman-Yakubovich-Popov Lemma for a class of positive hybrid dynamic linear systems which consist of a continuous-time system coupled with a discrete-time or a digital one. An extended discrete system, whose state vector contains both the digital one and the discretization of the continuous-time one at sampling instants, is a key analysis element in the formulation. The hyperstability and asymptotic hyperstability properties of the studied class of positive hybrid systems under feedback from any member of a nonlinear (and, eventually, time-varying class of controllers, which satisfies a Popov’s-type inequality, are also investigated as linked to the positive realness of the associated transfer matrices.

  18. Distributed transition-edge sensors for linearized position response in a phonon-mediated X-ray imaging spectrometer

    Science.gov (United States)

    Cabrera, Blas; Brink, Paul L.; Leman, Steven W.; Castle, Joseph P.; Tomada, Astrid; Young, Betty A.; Martínez-Galarce, Dennis S.; Stern, Robert A.; Deiker, Steve; Irwin, Kent D.

    2004-03-01

    For future solar X-ray satellite missions, we are developing a phonon-mediated macro-pixel composed of a Ge crystal absorber with four superconducting transition-edge sensors (TES) distributed on the backside. The X-rays are absorbed on the opposite side and the energy is converted into phonons, which are absorbed into the four TES sensors. By connecting together parallel elements into four channels, fractional total energy absorbed between two of the sensors provides x-position information and the other two provide y-position information. We determine the optimal distribution for the TES sub-elements to obtain linear position information while minimizing the degradation of energy resolution.

  19. A rotation-symmetric, position-sensitive annular detector for maximum counting rates

    International Nuclear Information System (INIS)

    Igel, S.

    1993-12-01

    The Germanium Wall is a semiconductor detector system containing up to four annular position sensitive ΔE-detectors from high purity germanium (HPGe) planned to complement the BIG KARL spectrometer in COSY experiments. The first diode of the system, the Quirl-detector, has a two dimensional position sensitive structure defined by 200 Archimedes' spirals on each side with opposite orientation. In this way about 40000 pixels are defined. Since each spiral element detects almost the same number of events in an experiment the whole system can be optimized for maximal counting rates. This paper describes a test setup for a first prototype of the Quirl-detector and the results of test measurements with an α-source. The detector current and the electrical separation of the spiral elements were measured. The splitting of signals due to the spread of charge carriers produced by an incident ionizing particle on several adjacent elements was investigated in detail and found to be twice as high as expected from calculations. Its influence on energy and position resolution is discussed. Electronic crosstalk via signal wires and the influence of noise from the magnetic spectrometer has been tested under experimental conditions. Additionally, vacuum feedthroughs based on printed Kapton foils pressed between Viton seals were fabricated and tested successfully concerning their vacuum and thermal properties. (orig.)

  20. A large, high performance, curved 2D position-sensitive neutron detector

    CERN Document Server

    Fried, J W; Mahler, G J; Makowiecki, D S; Mead, J A; Radeka, V; Schaknowski, N A; Smith, G C; Yu, B

    2002-01-01

    A new position-sensitive neutron detector has been designed and constructed for a protein crystallography station at LANL's pulsed neutron source. This station will be one of the most advanced instruments at a major neutron user facility for protein crystallography, fiber and membrane diffraction. The detector, based on neutron absorption in sup 3 He, has a large sensitive area of 3000 cm sup 2 , angular coverage of 120 deg. , timing resolution of 1 mu s, rate capability in excess of 10 sup 6 s sup - sup 1 , position resolution of about 1.5 mm FWHM, and efficiency >50% for neutrons of interest in the range 1-10 A. Features that are key to these remarkable specifications are the utilization of eight independently operating segments within a single gas volume, fabrication of the detector vessel and internal segments with a radius of curvature of about 70 cm, optimized position readout based on charge division and signal shaping with gated baseline restoration, and engineering design with high-strength aluminum ...

  1. A new amplifier for improving piezoelectric actuator linearity based on current switching in precision positioning

    International Nuclear Information System (INIS)

    Ru, Changhai; Chen, Liguo; Shao, Bing; Rong, Weibin; Sun, Lining

    2008-01-01

    Piezoelectric actuators have traditionally been driven by voltage amplifiers. When driven at large voltages these actuators exhibit a significant amount of distortion, known as hysteresis, which may reduce the stability robustness of the system in feedback control applications. Piezoelectric transducers are known to exhibit less hysteresis when driven with current or charge rather than voltage. Despite this advantage, such methods have found little practical application due to the poor low frequency response of present current and charge driver designs. In this paper, a new piezoelectric amplifier based on current switching is presented which can reduce hysteresis. Special circuits and a hybrid control algorithm realize quick and precise positioning. Experimental results demonstrate that the amplifier can be used for dynamic and static applications and low frequency bandwidths can also be achieved

  2. Application of digital waveform processing to position-sensitive proportional counter

    International Nuclear Information System (INIS)

    Takenaka, Yasuto; Uritani, Akira; Mori, Chizuo

    1995-01-01

    In a charge-division type position-sensitive proportional counter (PSPC) with an anode wire of small resistance, a reflected component from an opposite end and thermal noise involved in signals deteriorate the position resolution of the PSPC. A digital waveform processing method was applied to the reduction of these undesirable effects by skillfully utilizing their signal characteristics that can be observed as inversely correlative signals between two-output signals from both sides of the PSPC. The digital waveform processing could improve the position resolution compared to a conventional pulse height processing method with analog filters. When the digital waveform processing was applied to signals of an equivalent circuit simulating the PSPC, the position resolutions defined by the full width at half maximum were improved to about 30% of those of conventional analog pulse processing. In the case of an actual PSPC, the position resolutions by the digital waveform processing were improved by 4-10% as compared with those of conventional pulse height processing. (author)

  3. Visualization of Global Sensitivity Analysis Results Based on a Combination of Linearly Dependent and Independent Directions

    Science.gov (United States)

    Davies, Misty D.; Gundy-Burlet, Karen

    2010-01-01

    A useful technique for the validation and verification of complex flight systems is Monte Carlo Filtering -- a global sensitivity analysis that tries to find the inputs and ranges that are most likely to lead to a subset of the outputs. A thorough exploration of the parameter space for complex integrated systems may require thousands of experiments and hundreds of controlled and measured variables. Tools for analyzing this space often have limitations caused by the numerical problems associated with high dimensionality and caused by the assumption of independence of all of the dimensions. To combat both of these limitations, we propose a technique that uses a combination of the original variables with the derived variables obtained during a principal component analysis.

  4. Robust artificial neural network for reliability and sensitivity analyses of complex non-linear systems.

    Science.gov (United States)

    Oparaji, Uchenna; Sheu, Rong-Jiun; Bankhead, Mark; Austin, Jonathan; Patelli, Edoardo

    2017-12-01

    Artificial Neural Networks (ANNs) are commonly used in place of expensive models to reduce the computational burden required for uncertainty quantification, reliability and sensitivity analyses. ANN with selected architecture is trained with the back-propagation algorithm from few data representatives of the input/output relationship of the underlying model of interest. However, different performing ANNs might be obtained with the same training data as a result of the random initialization of the weight parameters in each of the network, leading to an uncertainty in selecting the best performing ANN. On the other hand, using cross-validation to select the best performing ANN based on the ANN with the highest R 2 value can lead to biassing in the prediction. This is as a result of the fact that the use of R 2 cannot determine if the prediction made by ANN is biased. Additionally, R 2 does not indicate if a model is adequate, as it is possible to have a low R 2 for a good model and a high R 2 for a bad model. Hence, in this paper, we propose an approach to improve the robustness of a prediction made by ANN. The approach is based on a systematic combination of identical trained ANNs, by coupling the Bayesian framework and model averaging. Additionally, the uncertainties of the robust prediction derived from the approach are quantified in terms of confidence intervals. To demonstrate the applicability of the proposed approach, two synthetic numerical examples are presented. Finally, the proposed approach is used to perform a reliability and sensitivity analyses on a process simulation model of a UK nuclear effluent treatment plant developed by National Nuclear Laboratory (NNL) and treated in this study as a black-box employing a set of training data as a test case. This model has been extensively validated against plant and experimental data and used to support the UK effluent discharge strategy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. A pulse stacking method of particle counting applied to position sensitive detection

    International Nuclear Information System (INIS)

    Basilier, E.

    1976-03-01

    A position sensitive particle counting system is described. A cyclic readout imaging device serves as an intermediate information buffer. Pulses are allowed to stack in the imager at very high counting rates. Imager noise is completely discriminated to provide very wide dynamic range. The system has been applied to a detector using cascaded microchannel plates. Pulse height spread produced by the plates causes some loss of information. The loss is comparable to the input loss of the plates. The improvement in maximum counting rate is several hundred times over previous systems that do not permit pulse stacking. (Auth.)

  6. A time resolving data acquisition system for multiple high-resolution position sensitive detectors

    International Nuclear Information System (INIS)

    Dimmler, D.G.

    1988-01-01

    An advanced time resolving data collection system for use in neutron and x-ray spectrometry has been implemented and put into routine operation. The system collects data from high-resolution position-sensitive area detectors with a maximum cumulative rate of 10/sup 6/ events per second. The events are sorted, in real-time, into many time-slice arrays. A programmable timing control unit allows for a wide choice of time sequences and time-slice array sizes. The shortest dwell time on a slice may be below 1 ms and the delay to switch between slices is zero

  7. The performance of prototype position-sensitive neutron detectors on SXD at ISIS

    International Nuclear Information System (INIS)

    Wilson, C.C.

    1989-02-01

    The performance of two position-sensitive neutron detector designed for use on the single crystal diffractometer (SXD) at ISIS is assessed. The two detectors examined were the Anger camera 6 Li-glass scintillator PSD and a prototype fibre-optic encoded PSD based on 6 Li-doped ZnS plastic scintillator. The latter detector is found to be both simpler to fabricate and to produce better results on the evidence to date. A summary of some of the expected science from SXD and the performance of the detectors with respect to this is also given. (author)

  8. Ultrafast readout of scintillating fibers using upgraded position-sensitive photomultipliers

    International Nuclear Information System (INIS)

    Onel, Y.

    1994-01-01

    Experimental results obtained with commercially available position-sensitive photomultipliers (PSPM) coupled with 0.5 mm diameter scintillating fiber arrays show some promising performances such as space resolution better than 200 μm and time resolution ∼ 1.5 ns with a detection efficiency higher than 90%. Major progress has also been recently achieved with an upgrade of a PSPM based on new grid dynode structures. Two-track spatial resolution has been studied using the upgraded PSPM. Initial studies demonstrate that two tracks separated by a minimum distance of 3 mm are resolved

  9. Measurement and analysis of field-induced crystallographic texture using curved position-sensitive diffraction detectors

    DEFF Research Database (Denmark)

    Simons, Hugh; Daniels, John E.; Studer, Andrew J.

    2014-01-01

    This paper outlines measurement and analysis methodologies created for determining the structural responses of electroceramics to an electric field. A sample stage is developed to apply electric fields to ceramic materials at elevated temperatures during neutron diffraction experiments. The tested...... employing a curved positive sensitive detector. Methodologies are proposed to account for the geometrical effects when vector fields are applied to textured materials with angularly dispersive detector geometries. Representative results are presented for the ferroelectric (Bi1/2Na1/2)TiO3-6%BaTiO3 (BNT-6BT...

  10. A new position-sensitive transmission detector for epithermal neutron imaging

    International Nuclear Information System (INIS)

    Schooneveld, E M; Kockelmann, W; Rhodes, N; Tardocchi, M; Gorini, G; Perelli Cippo, E; Nakamura, T; Postma, H; Schillebeeckx, P

    2009-01-01

    A new neutron resonant transmission (NRT) detector for epithermal neutron imaging has been designed and built for the ANCIENT CHARM project, which is developing a set of complementary neutron imaging methods for analysis of cultural heritage objects. One of the techniques being exploited is NRT with the aim of performing bulk elemental analysis. The 16-pixel prototype NRT detector consists of independent crystals of 2 x 2 mm pixel size, which allow for 2D position-sensitive transmission measurements with epithermal neutrons. First results obtained at the ISIS pulsed spallation neutron source are presented. (fast track communication)

  11. Conceptual design of elliptical cavities for intensity and position sensitive beam measurements in storage rings

    International Nuclear Information System (INIS)

    Sanjari, M S; Chen, X; Hülsmann, P; Litvinov, Yu A; Nolden, F; Piotrowski, J; Steck, M; Stöhlker, Th

    2015-01-01

    Position sensitive beam monitors are indispensable for the beam diagnostics in storage rings. Apart from their applications in the measurements of beam parameters, they can be used in non-destructive in-ring decay studies of radioactive ion beams as well as enhancing precision in the isochronous mass measurement technique. In this work, we introduce a novel approach based on cavities with elliptical cross-section, in order to compensate the limitations of known designs for the application in ion storage rings. The design is aimed primarily for future heavy ion storage rings of the FAIR project. The conceptual design is discussed together with simulation results. (paper)

  12. Low and high linear energy transfer radiation sensitization of HCC cells by metformin

    International Nuclear Information System (INIS)

    Kim, Eun Ho; Jung, Won-Gyun; Kim, Mi-Sook; Cho, Chul-Koo; Jeong, Youn Kyoung; Jeong, Jae-Hoon

    2014-01-01

    The purpose of this study was to investigate the efficacy of metformin as a radiosensitizer for use in combination therapy for human hepatocellular carcinoma (HCC). Three human HCC cell lines (Huh7, HepG2, Hep3B) and a normal human hepatocyte cell line were treated with metformin alone or with radiation followed by metformin. In vitro tests were evaluated by clonogenic survival assay, FACS analysis, western blotting, immunofluorescence and comet assay. Metformin significantly enhanced radiation efficacy under high and low Linear Energy Transfer (LET) radiation conditions in vitro. In combination with radiation, metformin abrogated G2/M arrest and increased the cell population in the sub-G1 phase and the ROS level, ultimately increasing HCC cellular apoptosis. Metformin inhibits the repair of DNA damage caused by radiation. The radiosensitizing effects of metformin are much higher in neutron (high LET)-irradiated cell lines than in γ (low LET)-irradiated cell lines. Metformin only had a moderate effect in normal hepatocytes. Metformin enhances the radiosensitivity of HCC, suggesting it may have clinical utility in combination cancer treatment with high-LET radiation. (author)

  13. Identifying Moderators of the Link Between Parent and Child Anxiety Sensitivity: The Roles of Gender, Positive Parenting, and Corporal Punishment.

    Science.gov (United States)

    Graham, Rebecca A; Weems, Carl F

    2015-07-01

    A substantial body of literature suggests that anxiety sensitivity is a risk factor for the development of anxiety problems and research has now begun to examine the links between parenting, parent anxiety sensitivity and their child's anxiety sensitivity. However, the extant literature has provided mixed findings as to whether parent anxiety sensitivity is associated with child anxiety sensitivity, with some evidence suggesting that other factors may influence the association. Theoretically, specific parenting behaviors may be important to the development of child anxiety sensitivity and also in understanding the association between parent and child anxiety sensitivity. In this study, 191 families (n = 255 children and adolescents aged 6-17 and their parents) completed measures of child anxiety sensitivity (CASI) and parenting (APQ-C), and parents completed measures of their own anxiety sensitivity (ASI) and their parenting (APQ-P). Corporal punishment was associated with child anxiety sensitivity and the child's report of their parent's positive parenting behaviors moderated the association between parent and child anxiety sensitivity. The child's gender was also found to moderate the association between parent and child anxiety sensitivity, such that there was a positive association between girls' and their parents anxiety sensitivity and a negative association in boys. The findings advance the understanding of child anxiety sensitivity by establishing a link with corporal punishment and by showing that the association between parent and child anxiety sensitivity may depend upon the parenting context and child's gender.

  14. A two-dimensional position sensitive gas chamber with scanned charge transfer readout

    International Nuclear Information System (INIS)

    Gomez, F.; Iglesias, A.; Lobato, R.; Mosquera, J.; Pardo, J.; Pena, J.; Pazos, A.; Pombar, M.; Rodriguez, A.

    2003-01-01

    We have constructed and tested a two-dimensional position sensitive parallel-plate gas ionization chamber with scanned charge transfer readout. The scan readout method described here is based on the development of a new position-dependent charge transfer technique. It has been implemented by using gate strips perpendicularly oriented to the collector strips. This solution reduces considerably the number of electronic readout channels needed to cover large detector areas. The use of a 25 μm thick kapton etched circuit allows high charge transfer efficiency with a low gating voltage, consequently needing a very simple commutating circuit. The present prototype covers 8x8 cm 2 with a pixel size of 1.27x1.27 mm 2 . Depending on the intended use and beam characteristics a smaller effective pixel is feasible and larger active areas are possible. This detector can be used for X-ray or other continuous beam intensity profile monitoring

  15. Penicillin sensitivity among children without a positive history for penicillin allergy.

    Science.gov (United States)

    Cetinkaya, Feyzullah; Cag, Yakup

    2004-06-01

    To establish the prevalence of positive penicillin skin tests among outpatients without any drug reaction history. Skin testing was performed in 147 children (aged 6-13 years) who had had received a penicillin preparation at least three times in the last 12 months without any allergic reaction. Before testing, detailed pediatric and allergy history were learned and then all children were tested with benzyl penicilloyl polylysin (PPL) and mixture of minor antigenic determinants. The test procedures were made epidermally and intradermally subsequently in every subject. The overall frequency of positive skin reactions to penicillin antigens was 10.2%. A mild systemic reaction was observed in one of the children during testing with PPL. We concluded that frequent use of penicillin and other beta-lactam antibiotics leads to sensitization of children in our study population despite these children seem to be asymptomatic during testing time. Copyright 2004 Blackwell Munksgaard

  16. Derivation of the point spread function for zero-crossing-demodulated position-sensitive detectors

    International Nuclear Information System (INIS)

    Nowlin, C.H.

    1976-07-01

    This work is a mathematical derivation of a high-quality approximation to the point spread function for position-sensitive detectors (PSDs) that use pulse-shape modulation and crossover-time demodulation. The approximation is determined as a general function of the input signals to the crossover detectors so as to enable later determination of optimum position-decoding filters for PSDs. This work is precisely applicable to PSDs that use either RC or LC transmission line encoders. The effects of random variables, such as charge collection time, in the encoding process are included. In addition, this work presents a new, rigorous method for the determination of upper and lower bounds for conditional crossover-time distribution functions (closely related to first-passage-time distribution functions) for arbitrary signals and arbitrary noise covariance functions

  17. First Investigation on a novel 2D position sensitive semiconductor detector concept

    CERN Document Server

    Bassignana, D; Jaramillo, R; Lozano, M; Munoz, F.J; Pellegrini, G; Quirion, D; Vila, I

    2012-01-01

    This paper presents a first study of the performance of a novel 2D position-sensitive microstrip detector, where the resistive charge division method was implemented by replacing the metallic electrodes with resistive electrodes made of polycrystalline silicon. A characterization of two proof-of-concept prototypes with different values of the electrode resistivity was carried out using a pulsed Near Infra-Red laser. The experimental data were compared with the electrical simulation of the sensor equivalent circuit coupled to simple electronics readout circuits. The good agreement between experimental and simulation results establishes the soundness of resistive charge division method in silicon microstrip sensors and validates the developed simulation as a tool for the optimization of future sensor prototypes. Spatial resolution in the strip length direction depends on the ionizing event position. The average value obtained from the protype analysis is close to 1.2% of the strip length for a 6 MIP signal.

  18. First results from Position-Sensitive quantum calorimeters using Mo/Au Transition-Edge Sensors

    International Nuclear Information System (INIS)

    Figueroa-Feliciano, Enectali; Chervenak, Jay; Finkbeiner, Fred M.; Li, Mary; Lindeman, Mark A.; Stahle, Caroline K.; Stahle, Carl M.

    2002-01-01

    We report the first results from a high-energy-resolution imaging spectrometer called a Position-Sensitive Transition-Edge Sensor (PoST). A PoST is a quantum calorimeter consisting of two Transition Edge Sensors (TESs) on the ends of a long absorber to do one dimensional imaging spectroscopy. Comparing rise time and energy information, the position of the event in the PoST is determined. Energy is inferred from the sum of the two pulses. We have fabricated 7- and 15-pixel PoSTs using Mo-Au TESs and Au absorbers. We have achieved 32 eV FWHM energy resolution at 1.5 keV with a 7-pixel PoST calorimeter

  19. Correlation of results obtained by in-vivo optical spectroscopy with measured blood oxygen saturation using a positive linear regression fit

    Science.gov (United States)

    McCormick, Patrick W.; Lewis, Gary D.; Dujovny, Manuel; Ausman, James I.; Stewart, Mick; Widman, Ronald A.

    1992-05-01

    Near infrared light generated by specialized instrumentation was passed through artificially oxygenated human blood during simultaneous sampling by a co-oximeter. Characteristic absorption spectra were analyzed to calculate the ratio of oxygenated to reduced hemoglobin. A positive linear regression fit between diffuse transmission oximetry and measured blood oxygenation over the range 23% to 99% (r2 equals .98, p signal was observed in the patient over time. The procedure was able to be performed clinically without difficulty; rSO2 values recorded continuously demonstrate the usefulness of the technique. Using the same instrumentation, arterial input and cerebral response functions, generated by IV tracer bolus, were deconvoluted to measure mean cerebral transit time. Date collected over time provided a sensitive index of changes in cerebral blood flow as a result of therapeutic maneuvers.

  20. Positive alcohol use expectancies moderate the association between anxiety sensitivity and alcohol use across adolescence.

    Science.gov (United States)

    Borges, Allison M; Lejuez, Carl W; Felton, Julia W

    2018-06-01

    Anxiety sensitivity (AS), or the fear of anxious symptoms and the belief that these symptoms may have negative physical, social, and cognitive consequences, is one personality trait that emerges in early adolescence and may be linked to alcohol use. However, findings are equivocal as to whether elevated AS during adolescence directly predicts alcohol use. Adolescents do report increases in positive alcohol use expectancies during this developmental period, and these expectancies have been found to be significantly associated with alcohol use. The current study examined whether positive alcohol use expectancies and AS in early adolescence predicted changes in alcohol use throughout adolescence. This aim was examined via secondary data analyses from a longitudinal study examining the development of risk behaviors in adolescents. Results of univariate latent growth curve modeling suggest that AS alone was not a significant predictor of baseline alcohol use or change in use over time after controlling for gender, age, and self-reported anxiety. However, AS in early adolescence was found to be a significant predictor of increases in alcohol use across adolescence for youth who reported greater positive alcohol use expectancies. These results indicate that beliefs regarding the positive effects of alcohol use are an important moderator in the relation between AS and change in alcohol use during adolescence. Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Serial position effects are sensitive predictors of conversion from MCI to Alzheimer's disease dementia.

    Science.gov (United States)

    Egli, Simone C; Beck, Irene R; Berres, Manfred; Foldi, Nancy S; Monsch, Andreas U; Sollberger, Marc

    2014-10-01

    It is unclear whether the predictive strength of established cognitive variables for progression to Alzheimer's disease (AD) dementia from mild cognitive impairment (MCI) varies depending on time to conversion. We investigated which cognitive variables were best predictors, and which of these variables remained predictive for patients with longer times to conversion. Seventy-five participants with MCI were assessed on measures of learning, memory, language, and executive function. Relative predictive strengths of these measures were analyzed using Cox regression models. Measures of word-list position-namely, serial position scores-together with Short Delay Free Recall of word-list learning best predicted conversion to AD dementia. However, only serial position scores predicted those participants with longer time to conversion. Results emphasize that the predictive strength of cognitive variables varies depending on time to conversion to dementia. Moreover, finer measures of learning captured by serial position scores were the most sensitive predictors of AD dementia. Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

  2. Development of a position-sensitive fission counter and measurement of neutron flux distributions

    International Nuclear Information System (INIS)

    Yamagishi, Hideshi; Soyama, Kazuhiko; Kakuta, Tsunemi

    2001-08-01

    A position-sensitive fission counter (PSFC) that operates in high neutron flux and high gamma-ray background such as at the side of a power reactor vessel has been developed. Neutron detection using the PSFC with a solenoid electrode is based on a delay-line method. The PSFC that has the outer diameter of 25 mm and the sensitive length of 1000 mm was manufactured for investigation of the performances. The PSFC provided output current pulses that were sufficiently higher than the alpha noise, though the PSFC has a solenoid electrode and large electrode-capacitance. The S/N ratio of PSFC outputs proved to be higher than that of ordinary fission counters with 200 mm sensitive length. A performance test to measure neutron flux distributions by a neutron measuring system with the PSFC was carried out by the side of a graphite pile, W2.4 x H1.4 x L1.2 m, with neutron sources, Am-Be 370 GBq x 2. It was confirmed that the neutron flux distribution was well measured with the system. (author)

  3. Sensitivity and offset calibration for the beam position monitors at the Advanced Photon Source

    International Nuclear Information System (INIS)

    Chung, Y.; Barr, D.; Decker, G.; Evans, K. Jr.; Kahana, E.

    1995-01-01

    The beam position monitors (BPMs) play a critically important role in commissioning and operation of accelerators. Accurate determination of the offsets relative to the magnetic axis and sensitivities of individual BPMs is thus needed. We will describe in this paper the schemes for calibrating all of the 360 BPMs for sensitivity and offset in the 7-GeV Advanced Photon Source (APS) storage ring and the results. For the sensitivity calibration, a 2-dimensional map of the BPM response in the aluminum vacuum chamber is obtained theoretically, which is combined with the measured nonlinear response of the BPM electronics. A set of 2-dimensional polynomial coefficients is then obtained to approximate the result analytically. The offset calibration of the BPMs is done relative to the magnetic axis of the quadrupoles using the beam. This avoids the problem arising from various mechanical sources as well as the offset in the processing electronics. The measurement results for the resolution and long-term drift of the BPM electronics shows 0.06-μm/√Hz resolution and 2-μm/hr drift over a period of 1.5 hrs

  4. Development of a geometric uncertainty model describing the accuracy of position-sensitive, coincidence neutron detection

    Energy Technology Data Exchange (ETDEWEB)

    Trivelpiece, Cory L., E-mail: cory@psu.ed [Department of Mechanical and Nuclear Engineering, The Pennsylvania, State University, University Park, PA 16802 (United States); Brenizer, J.S. [Department of Mechanical and Nuclear Engineering, The Pennsylvania, State University, University Park, PA 16802 (United States)

    2011-01-01

    A diameter of uncertainty (D{sub u}) was derived from a geometric uncertainty model describing the error that would be introduced into position-sensitive, coincidence neutron detection measurements by charged-particle transport phenomena and experimental setup. The transport of {alpha} and Li ions, produced by the {sup 10}B(n,{alpha}) {sup 7}Li reaction, through free-standing boro-phosphosilicate glass (BPSG) films was modeled using the Monte Carlo code SRIM, and the results of these simulations were used as input to determine D{sub u} for position-sensitive, coincidence techniques. The results of these calculations showed that D{sub u} is dependent on encoder separation, the angle of charged particle emission, and film thickness. For certain emission scenarios, the magnitude of D{sub u} is larger than the physical size of the neutron converting media that were being modeled. Spheres of uncertainty were developed that describe the difference in flight path times among the bounding-case emission scenarios that were considered in this work. It was shown the overlapping spheres represent emission angles and particle flight path lengths that would be difficult to resolve in terms of particle time-of-flight measurements. However, based on the timing resolution of current nuclear instrumentation, emission events that yield large D{sub u} can be discriminated by logical arguments during spectral deconvolution.

  5. Position-sensitive radiation monitoring (surface contamination monitor). Innovative technology summary report

    International Nuclear Information System (INIS)

    1999-06-01

    The Shonka Research Associates, Inc. Position-Sensitive Radiation Monitor both detects surface radiation and prepares electronic survey map/survey report of surveyed area automatically. The electronically recorded map can be downloaded to a personal computer for review and a map/report can be generated for inclusion in work packages. Switching from beta-gamma detection to alpha detection is relatively simple and entails moving a switch position to alpha and adjusting the voltage level to an alpha detection level. No field calibration is required when switching from beta-gamma to alpha detection. The system can be used for free-release surveys because it meets the federal detection level sensitivity limits requires for surface survey instrumentation. This technology is superior to traditionally-used floor contamination monitor (FCM) and hand-held survey instrumentation because it can precisely register locations of radioactivity and accurately correlate contamination levels to specific locations. Additionally, it can collect and store continuous radiological data in database format, which can be used to produce real-time imagery as well as automated graphics of survey data. Its flexible design can accommodate a variety of detectors. The cost of the innovative technology is 13% to 57% lower than traditional methods. This technology is suited for radiological surveys of flat surfaces at US Department of Energy (DOE) nuclear facility decontamination and decommissioning (D and D) sites or similar public or commercial sites

  6. Position-sensitive radiation monitoring (surface contamination monitor). Innovative technology summary report

    Energy Technology Data Exchange (ETDEWEB)

    1999-06-01

    The Shonka Research Associates, Inc. Position-Sensitive Radiation Monitor both detects surface radiation and prepares electronic survey map/survey report of surveyed area automatically. The electronically recorded map can be downloaded to a personal computer for review and a map/report can be generated for inclusion in work packages. Switching from beta-gamma detection to alpha detection is relatively simple and entails moving a switch position to alpha and adjusting the voltage level to an alpha detection level. No field calibration is required when switching from beta-gamma to alpha detection. The system can be used for free-release surveys because it meets the federal detection level sensitivity limits requires for surface survey instrumentation. This technology is superior to traditionally-used floor contamination monitor (FCM) and hand-held survey instrumentation because it can precisely register locations of radioactivity and accurately correlate contamination levels to specific locations. Additionally, it can collect and store continuous radiological data in database format, which can be used to produce real-time imagery as well as automated graphics of survey data. Its flexible design can accommodate a variety of detectors. The cost of the innovative technology is 13% to 57% lower than traditional methods. This technology is suited for radiological surveys of flat surfaces at US Department of Energy (DOE) nuclear facility decontamination and decommissioning (D and D) sites or similar public or commercial sites.

  7. Ultrafast readout of scintillating fibres using upgraded position-sensitive photomultipliers

    CERN Document Server

    Agoritsas, V; Ditta, J; Dufournaud, J; Giacomich, R; Gorin, A M; Kuroda, K; Meshchanin, A P; Newsom, C R; Nurushev, S B; Önel, Y M; Okada, K; Oshima, N; Pauletta, G; Penzo, Aldo L; Rakhmatov, V E; Rykalin, V I; Salvato, G; Schiavon, R P; Sillou, D; Solovyanov, V L; Takeutchi, F; Vasilev, V; Vasilchenko, V G; Villari, A C C; Yamada, R; Yoshida, T; CERN. Geneva. Detector Research and Development Committee

    1991-01-01

    In view of the new possibilities for event detection and tracking in future multi-TeV collider experiments, we propose to improve the performance of position-sensitive photomultipliers and, with it, to realize an ultrafast readout device of scintillating fibres; this should play a unique role in the complex of a future vertex detector, owing to its inherent subnanosecond resolving time as well as its capability of an extremely high counting rate. Our proposal is first aimed at upgrading the position-sensitive PM, in particular its space and time resolutions. Full advantage of the new phototube will be demonstrated in its immediate application to a generic prototype of a scintillating-fibre detector. Our programme also includes intensive R&D on a real-time digitization of the multihit topology, which should provide an essential back-up to the vertex tracking at extremely high rates, one of the most difficult problems relevant to the expected high performance of the LHC.

  8. Sensitivity and specificity of oral HPV detection for HPV-positive head and neck cancer.

    Science.gov (United States)

    Gipson, Brooke J; Robbins, Hilary A; Fakhry, Carole; D'Souza, Gypsyamber

    2018-02-01

    The incidence of HPV-related head and neck squamous cell carcinoma (HPV-HNSCC) is increasing. Oral samples are easy and non-invasive to collect, but the diagnostic accuracy of oral HPV detection methods for classifying HPV-positive HNSCC tumors has not been well explored. In a systematic review, we identified eight studies of HNSCC patients meeting our eligibility criteria of having: (1) HPV detection in oral rinse or oral swab samples, (2) tumor HPV or p16 testing, (3) a publication date within the last 10 years (January 2007-May 2017, as laboratory methods change), and (4) at least 15 HNSCC cases. Data were abstracted from each study and a meta-analysis performed to calculate sensitivity and specificity. Eight articles meeting inclusion criteria were identified. Among people diagnosed with HNSCC, oral HPV detection has good specificity (92%, 95% CI = 82-97%) and moderate sensitivity (72%, 95% CI = 45-89%) for HPV-positive HNSCC tumor. Results were similar when restricted to studies with only oropharyngeal cancer cases, with oral rinse samples, or testing for HPV16 DNA (instead of any oncogenic HPV) in the oral samples. Among those who already have HNSCC, oral HPV detection has few false-positives but may miss one-half to one-quarter of HPV-related cases (false-negatives). Given these findings in cancer patients, the utility of oral rinses and swabs as screening tests for HPV-HNSCC among healthy populations is probably limited. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Flows of dioxins and furans in coastal food webs: inverse modeling, sensitivity analysis, and applications of linear system theory.

    Science.gov (United States)

    Saloranta, Tuomo M; Andersen, Tom; Naes, Kristoffer

    2006-01-01

    Rate constant bioaccumulation models are applied to simulate the flow of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the coastal marine food web of Frierfjorden, a contaminated fjord in southern Norway. We apply two different ways to parameterize the rate constants in the model, global sensitivity analysis of the models using Extended Fourier Amplitude Sensitivity Test (Extended FAST) method, as well as results from general linear system theory, in order to obtain a more thorough insight to the system's behavior and to the flow pathways of the PCDD/Fs. We calibrate our models against observed body concentrations of PCDD/Fs in the food web of Frierfjorden. Differences between the predictions from the two models (using the same forcing and parameter values) are of the same magnitude as their individual deviations from observations, and the models can be said to perform about equally well in our case. Sensitivity analysis indicates that the success or failure of the models in predicting the PCDD/F concentrations in the food web organisms highly depends on the adequate estimation of the truly dissolved concentrations in water and sediment pore water. We discuss the pros and cons of such models in understanding and estimating the present and future concentrations and bioaccumulation of persistent organic pollutants in aquatic food webs.

  10. A Non-linear Model for Predicting Tip Position of a Pliable Robot Arm Segment Using Bending Sensor Data

    Directory of Open Access Journals (Sweden)

    Elizabeth I. SKLAR

    2016-04-01

    Full Text Available Using pliable materials for the construction of robot bodies presents new and interesting challenges for the robotics community. Within the EU project entitled STIFFness controllable Flexible & Learnable manipulator for surgical Operations (STIFF-FLOP, a bendable, segmented robot arm has been developed. The exterior of the arm is composed of a soft material (silicone, encasing an internal structure that contains air-chamber actuators and a variety of sensors for monitoring applied force, position and shape of the arm as it bends. Due to the physical characteristics of the arm, a proper model of robot kinematics and dynamics is difficult to infer from the sensor data. Here we propose a non-linear approach to predicting the robot arm posture, by training a feed-forward neural network with a structured series of pressures values applied to the arm's actuators. The model is developed across a set of seven different experiments. Because the STIFF-FLOP arm is intended for use in surgical procedures, traditional methods for position estimation (based on visual information or electromagnetic tracking will not be possible to implement. Thus the ability to estimate pose based on data from a custom fiber-optic bending sensor and accompanying model is a valuable contribution. Results are presented which demonstrate the utility of our non-linear modelling approach across a range of data collection procedures.

  11. Development of Position-Sensitive Magnetic Calorimeters for X-Ray Astronomy

    Science.gov (United States)

    Bandler, SImon; Stevenson, Thomas; Hsieh, Wen-Ting

    2011-01-01

    Metallic magnetic calorimeters (MMC) are one of the most promising devices to provide very high energy resolution needed for future astronomical x-ray spectroscopy. MMC detectors can be built to large detector arrays having thousands of pixels. Position-sensitive magnetic (PoSM) microcalorimeters consist of multiple absorbers thermally coupled to one magnetic micro calorimeter. Each absorber element has a different thermal coupling to the MMC, resulting in a distribution of different pulse shapes and enabling position discrimination between the absorber elements. PoSMs therefore achieve the large focal plane area with fewer number of readout channels without compromising spatial sampling. Excellent performance of PoSMs was achieved by optimizing the designs of key parameters such as the thermal conductance among the absorbers, magnetic sensor, and heat sink, as well as the absorber heat capacities. Micro fab ri - cation techniques were developed to construct four-absorber PoSMs, in which each absorber consists of a two-layer composite of bismuth and gold. The energy resolution (FWHM full width at half maximum) was measured to be better than 5 eV at 6 keV x-rays for all four absorbers. Position determination was demonstrated with pulse-shape discrimination, as well as with pulse rise time. X-ray microcalorimeters are usually designed to thermalize as quickly as possible to avoid degradation in energy resolution from position dependence to the pulse shapes. Each pixel consists of an absorber and a temperature sensor, both decoupled from the cold bath through a weak thermal link. Each pixel requires a separate readout channel; for instance, with a SQUID (superconducting quantum interference device). For future astronomy missions where thousands to millions of resolution elements are required, having an individual SQUID readout channel for each pixel becomes difficult. One route to attaining these goals is a position-sensitive detector in which a large continuous or

  12. Preliminary Study of Position-Sensitive Large-Area Radiation Portal Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Chang Hwy; Kim, Hyunok; Moon, Myung Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Jongyul [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Park, Jong Won; Lim, Yong Kon [Korea Institute of Ocean Science and Technology, Daejeon (Korea, Republic of)

    2013-10-15

    An RPM, which is a passive inspection method, is a system for monitoring the movement of radioactive materials at an airport, seaport, border, etc. To detect a γ-ray, an RPM using the plastic scintillator is generally used. The method of γ-ray detection using an RPM with a plastic scintillator is to measure lights generated by an incident γ-ray in the scintillator. Generally, a large-area RPM uses one or two photomultiplier tubes (PMT) for light collection. However, in this study, we developed a 4-ch RPM that can measure the radiation signal using 4 PMTs. The reason for using 4 PMTs is to calculate the position of the radiation source. In addition, we developed an electric device for acquisition of a 4-ch output signal at the same time. To estimate the performance of the developed RPM, we performed an RPM test using a {sup 60}Co γ-ray check source. In this study, we performed the development of a 4-ch RPM. The major function of the typical RPM is to measure the radiation. However, we developed a position-sensitive 4-ch RPM, which can be used to measure the location of the radiation source, as well as the radiation measurement, at the same time. In the future, we plan to develop an algorithm for a position detection of the radiation. In addition, an algorithm will be applied to an RPM.

  13. Simulation and optimisation of a position sensitive scintillation detector with wavelength shifting fibers for thermal neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Herzkamp, Matthias; Engels, Ralf; Kemmerling, Guenter [ZEA-2, Forschungszentrum Juelich (Germany); Brueckel, Thomas [JCNS, Forschungszentrum Juelich (Germany); Stahl, Achim [III. Physikalisches Institut B, RWTH Aachen (Germany); Waasen, Stefan van [ZEA-2, Forschungszentrum Juelich (Germany); Faculty of Engineering, University of Duisburg-Essen (Germany)

    2015-07-01

    In neutron scattering experiments it is important to have position sensitive large scale detectors for thermal neutrons. A detector based on a neutron scintillator with wave length shifting fibers is a new kind of such a detector. We present the simulation of the detector based on the microscopic structure of the scintillation material of the mentioned detector. It consists of a converter and a scintillation powder bound in a matrix. The converter in our case is lithium fluoride with enriched lithium 6, to convert thermal neutrons into high energetic alpha and triton particles. The scintillation material is silver doped zinc sulfide. We show that pulse height spectra obtained by these scintillators can be be explained by the simple model of randomly distributed spheres of zinc sulfide and lithium fluoride. With this model, it is possible to optimise the mass ratio of zinc sulfide to lithium fluoride with respect to detection efficiency and/or energy deposition in zinc sulfide.

  14. Environmental gram-positive mastitis treatment: in vitro sensitivity and bacteriologic cure.

    Science.gov (United States)

    Cattell, M B; Dinsmore, R P; Belschner, A P; Carmen, J; Goodell, G

    2001-09-01

    A clinical trial was conducted in a large dairy herd to determine the efficacy of intramammary pirlimycin hydrochloride administration during lactation for bacteriologic clearance of gram-positive environmental clinical and subclinical mastitis infections. Quarters infected with environmental streptococci that received pirlimycin therapy (13/28) were 1.8 times more likely to resolve infection than untreated quarters (5/14). The small numbers of quarters infected with coagulase-negative staphylococci resulted in inadequate power to assess treatment differences in cure rate. Although the association was not statistically significant, quarters from cows with sensitive environmental streptococci isolates from composite samples (8/13) resolved infection with treatment at approximately twice the rate of treated quarters with resistant isolates (3/10).

  15. A large-area, position-sensitive neutron detector with neutron/γ-ray discrimination capabilities

    International Nuclear Information System (INIS)

    Zecher, P.D.; Galonsky, A.; Kruse, J.J.; Gaff, S.J.; Ottarson, J.; Wang, J.; Seres, Z.; Ieki, K.; Iwata, Y.; Schelin, H.

    1997-01-01

    To further study neutron-rich halo nuclei, we have constructed a neutron detector array. The array consists of two separate banks of detectors, each of area 2 x 2 m 2 and containing 250 l of liquid scintillator. Each bank is position-sensitive to better than 10 cm. For neutron time-of-flight measurements, the time resolution of the detector has been demonstrated to be about 1 ns. By using the scintillator NE-213, we are able to distinguish between neutron and γ-ray signals above 1 MeV electron equivalent energy. Although the detector array was constructed for a particular experiment it has also been used in a number of other experiments. (orig.)

  16. Design and development of 1 mm resolution PET detectors with position-sensitive PMTs

    CERN Document Server

    Shao, Y; Chatziioannou, A F

    2002-01-01

    We report our investigation of a positron emission tomography (PET) detector with 1 m spatial resolution. The prototype detector consists of a 9x9 array of 1x1x10 mm sup 3 lutetium oxyorthosilicate (LSO) scintillator crystals coupled to Hamamatsu R5900-M64 or R5900-C12 position sensitive PMT by either optical fibers or an optical fiber bundle. With a 511 eV gamma source, the intrinsic spatial resolution of this detector was measured to be 0.92 mm. All crystals were well resolved in the flood source histogram. The measured energy and coincidence timing resolutions were around 26% and 4 ns, respectively, demonstrating that sufficient light can be extracted from these small crystals for PET applications.

  17. A large area position-sensitive ionization chamber for heavy-ion-induced reaction studies

    CERN Document Server

    Pant, L M; Dinesh, B V; Thomas, R G; Saxena, A; Sawant, Y S; Choudhury, R K

    2002-01-01

    A large area position-sensitive ionization chamber with a wide dynamic range has been developed to measure the mass, charge and energy of the heavy ions and the fission fragments produced in heavy-ion-induced reactions. The split anode geometry of the detector makes it suitable for both particle identification and energy measurements for heavy ions and fission fragments. The detector has been tested with alpha particles from sup 2 sup 4 sup 1 Am- sup 2 sup 3 sup 9 Pu source, fission fragments from sup 2 sup 5 sup 2 Cf and the heavy-ion beams from the 14UD Mumbai Pelletron accelerator facility. Using this detector, measurements on mass and total kinetic energy distributions in heavy-ion-induced fusion-fission reactions have been carried out for a wide range of excitation energies. Results on deep inelastic collisions and mass-energy correlations on different systems using this detector setup are discussed.

  18. Topological trigger device using scintillating fibers and position-sensitive photomultipliers

    Energy Technology Data Exchange (ETDEWEB)

    Kuroda, Keiichi; Dufournaud, J; Sillou, D [Laboratoire d' Annecy-le-Vieux de Physique des Particules (LAPP), 74 (France); Agoritsas, V [European Organization for Nuclear Research, Geneva (Switzerland); Bystricky, G; Lehar, F; Lesquen, A de [CEN-Saclay, 91 - Gif-sur-Yvette (France); Giacomich, R; Pauletta, G; Penzo, A; Salvato, G; Schiavon, P; Villari, A [INFN, Messina (Italy) INFN, Trieste (Italy) INFN, Udine (Italy); Gorin, A M; Meschanin, A P; Nurushev, S B; Rakhmatov, V E; Rykalin, V L; Solovyanov, V L; Vasiliev, A N; Vasil' chencko, V G [Institute for High Energy Physics, Serpukhov (USSR); Oshima, N; Yamada, R [Fermi National Accelerator Lab., Batavia, IL (USA); Takeutchi, F [Kyoto-Sanyo Univ., Kyoto (Japan); Yoshida, T [Osaka City Univ. (Japan); Akchurin, N; Onel, Y; Newsom, C

    1991-07-01

    An approach to a high quality of the Level-1 Trigger is investigated on the basis of a topological trigger device. It will be realized by using scintillating fibers and position-sensitive photomultipliers, both considered as potential candidates of new detector-components thanks to their excellent time characteristics and high radiation resistances. The device is characterized in particular by its simple concept and reliable operation supported by the mature technologies emploied. The major interests of such a scheme under LHC environments reside in its capability of selcting high pperpendicular to tracks in real time, its optional immunity against low pperpendicular to tracks and loopers, as well as its effective links to other associated devices in the complex of a vertex detector. (orig.).

  19. Depth of interaction detection with enhanced position-sensitive proportional resistor network

    International Nuclear Information System (INIS)

    Lerche, Ch.W.; Benlloch, J.M.; Sanchez, F.; Pavon, N.; Gimenez, N.; Fernandez, M.; Gimenez, M.; Sebastia, A.; Martinez, J.; Mora, F.J.

    2005-01-01

    A new method of determining the depth of interaction of γ-rays in thick inorganic scintillation crystals was tested experimentally. The method uses the strong correlation between the width of the scintillation light distribution within large continuous crystals and the γ-ray's interaction depth. This behavior was successfully reproduced by a theoretical model distribution based on the inverse square law. For the determination of the distribution's width, its standard deviation σ is computed using an enhanced position-sensitive proportional resistor network which is often used in γ-ray-imaging devices. Minor changes of this known resistor network allow the analog and real-time determination of the light distribution's 2nd moment without impairing the measurement of the energy and centroid. First experimental results are presented that confirm that the described method works correctly. Since only some cheap electronic components, but no additional detectors or crystals are required, the main advantage of this method is its low cost

  20. On determining dead layer and detector thicknesses for a position-sensitive silicon detector

    Science.gov (United States)

    Manfredi, J.; Lee, Jenny; Lynch, W. G.; Niu, C. Y.; Tsang, M. B.; Anderson, C.; Barney, J.; Brown, K. W.; Chajecki, Z.; Chan, K. P.; Chen, G.; Estee, J.; Li, Z.; Pruitt, C.; Rogers, A. M.; Sanetullaev, A.; Setiawan, H.; Showalter, R.; Tsang, C. Y.; Winkelbauer, J. R.; Xiao, Z.; Xu, Z.

    2018-04-01

    In this work, two particular properties of the position-sensitive, thick silicon detectors (known as the "E" detectors) in the High Resolution Array (HiRA) are investigated: the thickness of the dead layer on the front of the detector, and the overall thickness of the detector itself. The dead layer thickness for each E detector in HiRA is extracted using a measurement of alpha particles emitted from a 212Pb pin source placed close to the detector surface. This procedure also allows for energy calibrations of the E detectors, which are otherwise inaccessible for alpha source calibration as each one is sandwiched between two other detectors. The E detector thickness is obtained from a combination of elastically scattered protons and an energy-loss calculation method. Results from these analyses agree with values provided by the manufacturer.

  1. Position sensitive detector with semiconductor and image electron tube comprising such a detector

    International Nuclear Information System (INIS)

    Roziere, Guy.

    1977-01-01

    This invention concerns a position sensitive detector comprising a semiconducting substrate. It also concerns the electron tubes in which the detector may be incorporated in order to obtain an image formed at the tube input by an incident flux of particles or radiation. When a charged particle or group of such particles, electrons in particular, enter the space charge region of an inversely biased semiconductor diode, the energy supplied by these particles releases in the diode a certain number of electron-hole pairs which move in the field existing in the area towards the diode contacts. A corresponding current arises in the connections of this diode which constitutes the signal corresponding to the incident energy. Such a tube or chain of tubes is employed in nuclear medicine for observing parts of the human body, particularly by gamma radiation [fr

  2. A position sensitive silicon detector for AEgIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy)

    CERN Multimedia

    Gligorova, A

    2014-01-01

    The AEḡIS experiment (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) is located at the Antiproton Decelerator (AD) at CERN and studies antimatter. The main goal of the AEḡIS experiment is to carry out the first measurement of the gravitational acceleration for antimatter in Earth’s gravitational field to a 1% relative precision. Such a measurement would test the Weak Equivalence Principle (WEP) of Einstein’s General Relativity. The gravitational acceleration for antihydrogen will be determined using a set of gravity measurement gratings (Moiré deflectometer) and a position sensitive detector. The vertical shift due to gravity of the falling antihydrogen atoms will be detected with a silicon strip detector, where the annihilation of antihydrogen will take place. This poster presents part of the development process of this detector.

  3. A microprogrammable high-speed data collection system for position sensitive X-ray detectors

    International Nuclear Information System (INIS)

    Hashizume, H.

    1984-01-01

    A high-speed data acquisition system has been designed which collects digital data from one- and two-dimensional position sensitive X-ray detectors at a maximum average data rate of 1 MHz. The system consists of two separate fast buffer memories, a 64 K word by 20-bit main storage, two timers, a display controller, a computer interface and a keyboard, controlled by a specially designed microprogrammable microprocessor. Data collection is performed by executing a microprogram stored in the control storage; data coming from a detector are first accumulated in a small but fast buffer memory by hardware and transferred to the main storage under control of the microprogram. This design not only permits time-resolved data collections but also provides maximum speed, flexibility and cost-effectiveness simultaneously. The system also accepts data from integrated detectors such as TV cameras. The system has been designed for use in experiments at conventional and synchrotron X-ray sources. (orig.)

  4. Topological trigger device using scintillating fibres and position-sensitive photomultipliers

    CERN Document Server

    Agoritsas, V; Dufournaud, J; Giacomich, R; Gorin, A M; Kuroda, K; Meshchanin, A P; Newsom, C R; Nurushev, S B; Önel, Y M; Oshima, N; Pauletta, G; Penzo, Aldo L; Rakhmatov, V E; Rykalin, V I; Salvato, G; Schiavon, R P; Sillou, D; Solovyanov, V L; Takeutchi, F; Vasilev, V; Vasilchenko, V G; Villari, A C C; Yamada, R; Toshida, T; CERN. Geneva. Detector Research and Development Committee

    1990-01-01

    An approach to a high-quality level-1 trigger is proposed on the basis of a topological device that will be realized by using scintillating fibres and position-sensitive photomultipliers, both of which are considered as potential candidates for new detector components, thanks to their excellent time characteristics and high radiation resistance. The device is characterized, in particular, by its simple concept and reliable functioning, which are a result of the mature technologies employed. In the LHC environment, the major interests of such a scheme reside in its capability to select high ptransv. tracks in real time, in its optional immunity against low ptransv. tracks and loopers, as well as in its effective links to other associated devices within the complex of a vertex detector.

  5. Computational design and characterization of a temperature-sensitive plasmid replicon for gram positive thermophiles

    Directory of Open Access Journals (Sweden)

    Olson Daniel G

    2012-05-01

    Full Text Available Abstract Background Temperature-sensitive (Ts plasmids are useful tools for genetic engineering, but there are currently none compatible with the gram positive, thermophilic, obligate anaerobe, Clostridium thermocellum. Traditional mutagenesis techniques yield Ts mutants at a low frequency, and therefore requires the development of high-throughput screening protocols, which are also not available for this organism. Recently there has been progress in the development of computer algorithms which can predict Ts mutations. Most plasmids currently used for genetic modification of C. thermocellum are based on the replicon of plasmid pNW33N, which replicates using the RepB replication protein. To address this problem, we set out to create a Ts plasmid by mutating the gene coding for the RepB replication protein using an algorithm designed by Varadarajan et al. (1996 for predicting Ts mutants based on the amino-acid sequence of the protein. Results A library of 34 mutant plasmids was designed, synthesized and screened, resulting in 6 mutants which exhibited a Ts phenotype. Of these 6, the one with the most temperature-sensitive phenotype (M166A was compared with the original plasmid. It exhibited lower stability at 48°C and was completely unable to replicate at 55°C. Conclusions The plasmid described in this work could be useful in future efforts to genetically engineer C. thermocellum, and the method used to generate this plasmid may be useful for others trying to make Ts plasmids.

  6. Position sensitive regions in a generic radiation sensor based on single event upsets in dynamic RAMs

    International Nuclear Information System (INIS)

    Darambara, D.G.; Spyrou, N.M.

    1997-01-01

    Modern integrated circuits are highly complex systems and, as such, are susceptible to occasional failures. Semiconductor memory devices, particularly dynamic random access memories (dRAMs), are subject to random, transient single event upsets (SEUs) created by energetic ionizing radiation. These radiation-induced soft failures in the stored data of silicon based memory chips provide the foundation for a new, highly efficient, low cost generic radiation sensor. The susceptibility and the detection efficiency of a given dRAM device to SEUs is a complicated function of the circuit design and geometry, the operating conditions and the physics of the charge collection mechanisms involved. Typically, soft error rates measure the cumulative response of all sensitive regions of the memory by broad area chip exposure in ionizing radiation environments. However, this study shows that many regions of a dynamic memory are competing charge collection centres having different upset thresholds. The contribution to soft fails from discrete regions or individual circuit elements of the memory device is unambiguously separated. Hence the use of the dRAM as a position sensitive radiation detector, with high spatial resolution, is assessed and demonstrated. (orig.)

  7. Linearization of the Principal Component Analysis method for radiative transfer acceleration: Application to retrieval algorithms and sensitivity studies

    International Nuclear Information System (INIS)

    Spurr, R.; Natraj, V.; Lerot, C.; Van Roozendael, M.; Loyola, D.

    2013-01-01

    Principal Component Analysis (PCA) is a promising tool for enhancing radiative transfer (RT) performance. When applied to binned optical property data sets, PCA exploits redundancy in the optical data, and restricts the number of full multiple-scatter calculations to those optical states corresponding to the most important principal components, yet still maintaining high accuracy in the radiance approximations. We show that the entire PCA RT enhancement process is analytically differentiable with respect to any atmospheric or surface parameter, thus allowing for accurate and fast approximations of Jacobian matrices, in addition to radiances. This linearization greatly extends the power and scope of the PCA method to many remote sensing retrieval applications and sensitivity studies. In the first example, we examine accuracy for PCA-derived UV-backscatter radiance and Jacobian fields over a 290–340 nm window. In a second application, we show that performance for UV-based total ozone column retrieval is considerably improved without compromising the accuracy. -- Highlights: •Principal Component Analysis (PCA) of spectrally-binned atmospheric optical properties. •PCA-based accelerated radiative transfer with 2-stream model for fast multiple-scatter. •Atmospheric and surface property linearization of this PCA performance enhancement. •Accuracy of PCA enhancement for radiances and bulk-property Jacobians, 290–340 nm. •Application of PCA speed enhancement to UV backscatter total ozone retrievals

  8. Photodiode array for position-sensitive detection using high X-ray flux provided by synchrotron radiation

    Science.gov (United States)

    Jucha, A.; Bonin, D.; Dartyge, E.; Flank, A. M.; Fontaine, A.; Raoux, D.

    1984-09-01

    Synchrotron radiation provides a high intensity source over a large range of wavelengths. This is the prominent quality that has laid the foundations of the EXAFS development (Extended X-ray Absorption Fine Structure). EXAFS data can be collected in different ways. A full scan requires 5 to 10 min, compared to the one-day data collection of a conventional Bremsstrahlung X-ray tube. Recently, by using the new photodiode array (R 1024 SFX) manufactured by Reticon, it has been possible to reduce the data collection time to less than 100 ms. The key elements of this new EXAFS method are a dispersive optics combined with a position sensitive detector able to work under very high flux conditions. The total aperture of 2500 μm × 25 μm for each pixel is well suited to spectroscopic applications. Besides its high dynamic range (> 10 4) and its linearity, the rapidity of the readout allows a flux of 10 9-10 10 photons/s over the 1024 sensing elements.

  9. A two-dimensional position sensitive gas chamber with scanned charge transfer readout

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, F. E-mail: faustgr@usc.es; Iglesias, A.; Lobato, R.; Mosquera, J.; Pardo, J.; Pena, J.; Pazos, A.; Pombar, M.; Rodriguez, A

    2003-10-21

    We have constructed and tested a two-dimensional position sensitive parallel-plate gas ionization chamber with scanned charge transfer readout. The scan readout method described here is based on the development of a new position-dependent charge transfer technique. It has been implemented by using gate strips perpendicularly oriented to the collector strips. This solution reduces considerably the number of electronic readout channels needed to cover large detector areas. The use of a 25 {mu}m thick kapton etched circuit allows high charge transfer efficiency with a low gating voltage, consequently needing a very simple commutating circuit. The present prototype covers 8x8 cm{sup 2} with a pixel size of 1.27x1.27 mm{sup 2}. Depending on the intended use and beam characteristics a smaller effective pixel is feasible and larger active areas are possible. This detector can be used for X-ray or other continuous beam intensity profile monitoring.

  10. Estimation of Compton Imager Using Single 3D Position-Sensitive LYSO Scintillator: Monte Carlo Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Taewoong; Lee, Hyounggun; Kim, Younghak; Lee, Wonho [Korea University, Seoul (Korea, Republic of)

    2017-07-15

    The performance of a Compton imager using a single three-dimensional position-sensitive LYSO scintillator detector was estimated using a Monte Carlo simulation. The Compton imager consisted of a single LYSO scintillator with a pixelized structure. The size of the scintillator and each pixel were 1.3 × 1.3 × 1.3 cm{sup 3} and 0.3 × 0.3 × 0.3 cm{sup 3}, respectively. The order of γ-ray interactions was determined based on the deposited energies in each detector. After the determination of the interaction sequence, various types of reconstruction algorithms such as simple back-projection, filtered back-projection, and list-mode maximum-likelihood expectation maximization (LM-MLEM) were applied and compared with each other in terms of their angular resolution and signal-tonoise ratio (SNR) for several γ-ray energies. The LM-MLEM reconstruction algorithm exhibited the best performance for Compton imaging in maintaining high angular resolution and SNR. The two sources of {sup 137}Cs (662 keV) could be distinguishable if they were more than 17 ◦ apart. The reconstructed Compton images showed the precise position and distribution of various radiation isotopes, which demonstrated the feasibility of the monitoring of nuclear materials in homeland security and radioactive waste management applications.

  11. Simulation and measurement of short infrared pulses on silicon position sensitive device

    International Nuclear Information System (INIS)

    Krapohl, D; Esebamen, O X; Nilsson, H E; Thungstroem, G

    2011-01-01

    Lateral position sensitive devices (PSD) are important for triangulation, alignment and surface measurements as well as for angle measurements. Large PSDs show a delay on rising and falling edges when irradiated with near infra-red light. This delay is also dependent on the spot position relative to the electrodes. It is however desirable in most applications to have a fast response. We investigated the responsiveness of a Sitek PSD in a mixed mode simulation of a two dimensional full sized detector. For simulation and measurement purposes focused light pulses with a wavelength of 850 nm, duration of 1μs and spot size of 280μm were used. The cause for the slopes of rise and fall time is due to time constants of the device capacitance as well as the photo-generation mechanism itself. To support the simulated results, we conducted measurements of rise and fall times on a physical device. Additionally, we quantified the homogeneity of the device by repositioning a spot of light from a pulsed ir-laser diode on the surface area.

  12. Position-sensitive proportional counter with low-resistance metal-wire anode

    International Nuclear Information System (INIS)

    Kopp, M.K.

    1980-01-01

    A position-sensitive proportional counter circuit is provided which uses a conventional (low-resistance, metal-wire anode) proportional counter for spatial resolution of an ionizing event along the anode of the counther. A pair of specially designed activecapacitance preamplifiers terminate the anode ends wherein the anode is treated as an RC line. The preamplifiers act as stabilized active capacitance loads and each is composed of a series-feedback, lownoise amplifier, a unity-gain, shunt-feedback amplifier whose output is connected through a feedback capacitor to the series-feedback amplifier input. The stabilized capacitance loading of the anode allows distributed RC-line position encoding and subsequent time difference decoding by sensing the difference in rise times of pulses at te anode ends where the difference is primarily in response to the distributed capacitance along the anode. This allows the use of lower resistance wire anodes for spatial radiation detection which simplifies the counter construction and handling of the anodes, and stabilizes the anode resistivity at high count rates

  13. Measurement of spatial dose-rate distribution using a position sensitive detector

    International Nuclear Information System (INIS)

    Emoto, T.; Torii, T.; Nozaki, T.; Ando, H.

    1994-01-01

    Recently, the radiation detectors using plastic scintillation fibers (PSF) have been developed to measure the positions exposed to radiation such as neutrons and high energy charged particles. In particular, the time of flight (TOF) method for measuring the difference of time that two directional signals of scintillation light reach both ends of a PSF is a rather simple method for the measurement of the spatial distribution of fast neutron fluence rate. It is possible to use the PSF in nuclear facility working areas because of its flexibility, small diameter and long length. In order to apply TOF method to measure spatial gamma dose rate distribution, the characteristic tests of a detector using PSFs were carried out. First, the resolution of irradiated positions and the counting efficiency were measured with collimated gamma ray. The sensitivity to unit dose rate was also obtained. The measurement of spatial dose rate distribution was also carried out. The sensor is made of ten bundled PSFs, and the experimental setup is described. The experiment and the results are reported. It was found that the PSF detector has the good performance to measure spatial gamma dose rate distribution. (K.I.)

  14. Semiautomatic imputation of activity travel diaries : use of global positioning system traces, prompted recall, and context-sensitive learning algorithms

    NARCIS (Netherlands)

    Moiseeva, A.; Jessurun, A.J.; Timmermans, H.J.P.; Stopher, P.

    2016-01-01

    Anastasia Moiseeva, Joran Jessurun and Harry Timmermans (2010), ‘Semiautomatic Imputation of Activity Travel Diaries: Use of Global Positioning System Traces, Prompted Recall, and Context-Sensitive Learning Algorithms’, Transportation Research Record: Journal of the Transportation Research Board,

  15. On the use of iterative techniques for feedforward control of transverse angle and position jitter in linear particle beam accelerators

    International Nuclear Information System (INIS)

    Barr, D.S.

    1995-01-01

    It is possible to use feedforward predictive control for transverse position and trajectory-angle jitter correction. The control procedure is straightforward, but creation of the predictive filter is not as obvious. The two process tested were the least mean squares (LMS) and Kalman filter methods. The controller parameters calculated offline are downloaded to a real-time analog correction system between macropulses. These techniques worked well for both interpulse (pulse-to-pulse) correction and intrapulse (within a pulse) correction with the Kalman filter method being the clear winner. A simulation based on interpulse data taken at the Stanford Linear Collider showed an improvement factor of almost three in the average rms jitter over standard feedback techniques for the Kalman filter. An improvement factor of over three was found for the Kalman filter on intrapulse data taken at the Los Alamos Meson Physics Facility. The feedforward systems also improved the correction bandwidth. copyright 1995 American Institute of Physics

  16. On the use of iterative techniques for feedforward control of transverse angle and position jitter in linear particle beam accelerators

    International Nuclear Information System (INIS)

    Barr, D.S.

    1994-01-01

    It is possible to use feedforward predictive control for transverse position and trajectory-angle jitter correction. The control procedure is straightforward, but creation of the predictive filter is not as obvious. The two processes tested were the least mean squares (LMS) and Kalman inter methods. The controller parameters calculated offline are downloaded to a real-time analog correction system between macropulses. These techniques worked well for both interpulse (pulse-to-pulse) correction and intrapulse (within a pulse) correction with the Kalman filter method being the clear winner. A simulation based on interpulse data taken at the Stanford Linear Collider showed an improvement factor of almost three in the average rms jitter over standard feedback techniques for the Kalman filter. An improvement factor of over three was found for the Kalman filter on intrapulse data taken at the Los Alamos Meson Physics Facility. The feedforward systems also improved the correction bandwidth

  17. Large, Linear, and Tunable Positive Magnetoresistance of Mechanically Stable Graphene Foam-Toward High-Performance Magnetic Field Sensors.

    Science.gov (United States)

    Sagar, Rizwan Ur Rehman; Galluzzi, Massimiliano; Wan, Caihua; Shehzad, Khurram; Navale, Sachin T; Anwar, Tauseef; Mane, Rajaram S; Piao, Hong-Guang; Ali, Abid; Stadler, Florian J

    2017-01-18

    Here, we present the first observation of magneto-transport properties of graphene foam (GF) composed of a few layers in a wide temperature range of 2-300 K. Large room-temperature linear positive magnetoresistance (PMR ≈ 171% at B ≈ 9 T) has been detected. The largest PMR (∼213%) has been achieved at 2 K under a magnetic field of 9 T, which can be tuned by the addition of poly(methyl methacrylate) to the porous structure of the foam. This remarkable magnetoresistance may be the result of quadratic magnetoresistance. The excellent magneto-transport properties of GF open a way toward three-dimensional graphene-based magnetoelectronic devices.

  18. Position sensitive photon detectors using epitaxial InGaAs/InAlAs quantum wells

    International Nuclear Information System (INIS)

    Ganbold, T.; Antonelli, M.; Cautero, G.; Jark, H.; Eichert, D.M.; Cucini, R.; Menk, R.H.; Biasiol, G.

    2014-01-01

    This work deals with the investigation of novel position-sensitive devices based on InGaAs/InAlAs quantum wells, which could be applied to several applications of either synchrotron or conventional light sources. Such devices may be used as fast and efficient detectors due to the direct, low-energy band gap and high electron mobility at room temperature. Metamorphic In 0.75 Ga 0.25 As/In 0.75 Al 0.25 As quantum wells containing a two-dimensional electron gas were grown by molecular beam epitaxy. Two devices with size of 5 × 5 mm 2 were prepared by using optical lithography. In the first, the active layers were segmented into four electrically insulated quadrants. Indium ohmic contacts were realized on the corner of each quadrant (for readout) and on the back surface (for bias). In the second, the quantum well was left unsegmented and covered by 400 nm of Al providing a single bias electrode, while four readout electrodes were fabricated on the back side by depositing and segmenting a Ni/Ge/Au layer. Photo-generated carriers can be collected at the readout electrodes by biasing from either the QW side or the back side of the devices during beam exposure. Individual currents obtained from each electrode allow monitoring of both the position and the intensity of the impinging beam for photon energies ranging from visible to hard X-ray. Such detector prototypes were tested with synchrotron radiation. Moreover, the position of the beam can be estimated with a precision of 800 nm in the segmented QW. A lower precision of 10 μm was recorded in the unsegmented QW due to the charge diffusion through the 500-μm-thick wafer, with however a lower electronic noise due to the better uniformity of the contacts

  19. Increased sensitivity to positive social stimuli in monozygotic twins at risk of bipolar vs. unipolar disorder.

    Science.gov (United States)

    Kærsgaard, S; Meluken, I; Kessing, L V; Vinberg, M; Miskowiak, K W

    2018-05-01

    Abnormalities in affective cognition are putative endophenotypes for bipolar and unipolar disorders but it is unclear whether some abnormalities are disorder-specific. We therefore investigated affective cognition in monozygotic twins at familial risk of bipolar disorder relative to those at risk of unipolar disorder and to low-risk twins. Seventy monozygotic twins with a co-twin history of bipolar disorder (n = 11), of unipolar disorder (n = 38) or without co-twin history of affective disorder (n = 21) were included. Variables of interest were recognition of and vigilance to emotional faces, emotional reactivity and -regulation in social scenarios and non-affective cognition. Twins at familial risk of bipolar disorder showed increased recognition of low to moderate intensity of happy facial expressions relative to both unipolar disorder high-risk twins and low-risk twins. Bipolar disorder high-risk twins also displayed supraliminal attentional avoidance of happy faces compared with unipolar disorder high-risk twins and greater emotional reactivity in positive and neutral social scenarios and less reactivity in negative social scenarios than low-risk twins. In contrast with our hypothesis, there was no negative bias in unipolar disorder high-risk twins. There were no differences between the groups in demographic characteristics or non-affective cognition. The modest sample size limited the statistical power of the study. Increased sensitivity and reactivity to positive social stimuli may be a neurocognitive endophenotype that is specific for bipolar disorder. If replicated in larger samples, this 'positive endophenotype' could potentially aid future diagnostic differentiation between unipolar and bipolar disorder. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Theory and Development of Position-Sensitive Quantum Calorimeters. Degree awarded by Stanford Univ.

    Science.gov (United States)

    Figueroa-Feliciano, Enectali; White, Nicholas E. (Technical Monitor)

    2001-01-01

    Quantum calorimeters are being developed as imaging spectrometers for future X-ray astrophysics observatories. Much of the science to be done by these instruments could benefit greatly from larger focal-plane coverage of the detector (without increasing pixel size). An order of magnitude more area will greatly increase the science throughput of these future instruments. One of the main deterrents to achieving this goal is the complexity of the readout schemes involved. We have devised a way to increase the number of pixels from the current baseline designs by an order of magnitude without increasing the number of channels required for readout. The instrument is a high energy resolution, distributed-readout imaging spectrometer called a Position-Sensitive Transition-Edge Sensor (POST). A POST is a quantum calorimeter consisting of two Transition-Edge Sensors (TESS) on the ends of a long absorber capable of one-dimensional imaging spectroscopy. Comparing rise time and energy information from the two TESS, the position of the event in the POST is determined. The energy of the event is inferred from the sum of the two pulses. We have developed a generalized theoretical formalism for distributed-readout calorimeters and apply it to our devices. We derive the noise theory and calculate the theoretical energy resolution of a POST. Our calculations show that a 7-pixel POST with 6 keV saturation energy can achieve 2.3 eV resolution, making this a competitive design for future quantum calorimeter instruments. For this thesis we fabricated 7- and 15-pixel POSTS using Mo/Au TESs and gold absorbers, and moved from concept drawings on scraps of napkins to a 32 eV energy resolution at 1.5 keV, 7-pixel POST calorimeter.

  1. Cherenkov radiation-based three-dimensional position-sensitive PET detector: A Monte Carlo study.

    Science.gov (United States)

    Ota, Ryosuke; Yamada, Ryoko; Moriya, Takahiro; Hasegawa, Tomoyuki

    2018-05-01

    Cherenkov radiation has recently received attention due to its prompt emission phenomenon, which has the potential to improve the timing performance of radiation detectors dedicated to positron emission tomography (PET). In this study, a Cherenkov-based three-dimensional (3D) position-sensitive radiation detector was proposed, which is composed of a monolithic lead fluoride (PbF 2 ) crystal and a photodetector array of which the signals can be readout independently. Monte Carlo simulations were performed to estimate the performance of the proposed detector. The position- and time resolution were evaluated under various practical conditions. The radiator size and various properties of the photodetector, e.g., readout pitch and single photon timing resolution (SPTR), were parameterized. The single photon time response of the photodetector was assumed to be a single Gaussian for the simplification. The photo detection efficiency of the photodetector was ideally 100% for all wavelengths. Compton scattering was included in simulations, but partly analyzed. To estimate the position at which a γ-ray interacted in the Cherenkov radiator, the center-of-gravity (COG) method was employed. In addition, to estimate the depth-of-interaction (DOI) principal component analysis (PCA), which is a multivariate analysis method and has been used to identify the patterns in data, was employed. The time-space distribution of Cherenkov photons was quantified to perform PCA. To evaluate coincidence time resolution (CTR), the time difference of two independent γ-ray events was calculated. The detection time was defined as the first photon time after the SPTR of the photodetector was taken into account. The position resolution on the photodetector plane could be estimated with high accuracy, by using a small number of Cherenkov photons. Moreover, PCA showed an ability to estimate the DOI. The position resolution heavily depends on the pitch of the photodetector array and the radiator

  2. The implications of non-linear biological oscillations on human electrophysiology for electrohypersensitivity (EHS) and multiple chemical sensitivity (MCS).

    Science.gov (United States)

    Sage, Cindy

    2015-01-01

    The 'informational content' of Earth's electromagnetic signaling is like a set of operating instructions for human life. These environmental cues are dynamic and involve exquisitely low inputs (intensities) of critical frequencies with which all life on Earth evolved. Circadian and other temporal biological rhythms depend on these fluctuating electromagnetic inputs to direct gene expression, cell communication and metabolism, neural development, brainwave activity, neural synchrony, a diversity of immune functions, sleep and wake cycles, behavior and cognition. Oscillation is also a universal phenomenon, and biological systems of the heart, brain and gut are dependent on the cooperative actions of cells that function according to principles of non-linear, coupled biological oscillations for their synchrony. They are dependent on exquisitely timed cues from the environment at vanishingly small levels. Altered 'informational content' of environmental cues can swamp natural electromagnetic cues and result in dysregulation of normal biological rhythms that direct growth, development, metabolism and repair mechanisms. Pulsed electromagnetic fields (PEMF) and radiofrequency radiation (RFR) can have the devastating biological effects of disrupting homeostasis and desynchronizing normal biological rhythms that maintain health. Non-linear, weak field biological oscillations govern body electrophysiology, organize cell and tissue functions and maintain organ systems. Artificial bioelectrical interference can give false information (disruptive signaling) sufficient to affect critical pacemaker cells (of the heart, gut and brain) and desynchronize functions of these important cells that orchestrate function and maintain health. Chronic physiological stress undermines homeostasis whether it is chemically induced or electromagnetically induced (or both exposures are simultaneous contributors). This can eventually break down adaptive biological responses critical to health

  3. The Research of Screw Thread Parameter Measurement Based on Position Sensitive Detector and Laser

    International Nuclear Information System (INIS)

    Tong, Q B; Ding, Z L; Chen, J C; Ai, L L; Yuan, F

    2006-01-01

    A technique and system of measuring screw thread parameter based on the theory of laser measurement is presented in this paper, which can be carried out the automated measurement of screw thread parameter. An inspection instrument was designed and produced, which included exterior imaging system of optical path, transverse displacement measurement system, axial displacement measurement system, and a module to deal with, control and assess the data in the upper system. The inspection and estimate of the screw thread contour curve were completed by using position sensitive device (PSD) as photoelectric detector to measure the coordinate data of the screw thread contour curve in the transverse section, and using precise raster to measure the axial displacement of the precision worktable under the screw thread test criterion., computer can gives a measured result according to coordinate data of the screw thread obtained by PSD. The relation between measured spot and image is established, and optimum design of the system organization are introduced, including the image length of receiving lens focal length optical system and the choice of PSD , and some main factor affected measuring precision are analyzed. The experimental results show that the measurement uncertainty of screw thread minor diameter can reach 0. 5μm, which can meet most requests for the measurement of screw thread parameter

  4. Single-Photon Computed Tomography With Large Position-Sensitive Phototubes*

    Science.gov (United States)

    Feldmann, John; Ranck, Amoreena; Saunders, Robert S.; Welsh, Robert E.; Bradley, Eric L.; Saha, Margaret S.; Kross, Brian; Majewski, Stan; Popov, Vladimir; Weisenberger, Andrew G.; Wojcik, Randolph

    2000-10-01

    Position-sensitive photomultiplier tubes (PSPMTs) coupled to pixelated CsI(Tl) scintillators have been used with parallel-hole collimators to view the metabolism in small animals of radiopharmaceuticals tagged with ^125I. We report here our preliminary results analyzed using a tomography program^1 written in IDL programming language. The PSPMTs are mounted on a rotating gantry so as to view the subject animal from any azimuth. Preliminary results to test the tomography algorithm have been obtained by placing a variety of plastic mouse-brain phantoms (loaded with Na^125I) in front of one of the detectors and rotating the phantom in steps through 360 degrees. Results of this simulation taken with a variety of collimator hole sizes will be compared and discussed. Extentions of this technique to the use of very small PSPMTs (Hamamatsu M-64) which are capable of a very close approach to those parts of the animal of greatest interest will be described. *Supported in part by The Department of Energy, The National Science Foundation, The American Diabetes Association, The Howard Hughes Foundation and The Jeffress Trust. 1. Tomography algorithm kindly provided by Dr. S. Meikle of The Royal Prince Albert Hospital, Sydney, Australia

  5. On-line evaluation of position-sensitive detector (PSD) diffraction data

    International Nuclear Information System (INIS)

    Stansfield, R.F.D.; McIntyre, G.J.

    1985-01-01

    The amount of raw data accumulated in a single-crystal diffraction experiment using a two-dimensional Position Sensitive Detector is usually so large that it is impracticable to store it. It is therefore necessary to reduce each local three-dimensional array of counts to a Bragg intensity, in a time not longer than the average time that one reflection is active. The statistically optimum procedure comprises an estimation of the background from a large number of counts, and an integration of peak intensity within a suitable three-dimensional envelope. A typical on-line method is described, using as an example the D19 diffractometer at the Institut Max von Laue - Paul Langevin (ILL) high-flux reactor. Current methods of PSD data reduction are reviewed. These fall into three groups according to the basis of the method used to find the integration envelope: (a) statistical criteria, (b) three-dimensional sigma(I)/I analysis, and (c) pre-calculation of the resolution function. On-line data reduction imposes special requirements on diagnostics to check the precision of the reduced data, especially at the start of an experiment, when any peculiarities must be identified and allowed for in the data-reduction procedure. The diagnostic possibilities resulting from the comparison of local with global characteristics of the background and the integration envelope are discussed. (author)

  6. Peak-shape analysis for protein neutron crystallography with position-sensitive detectors

    International Nuclear Information System (INIS)

    Schoenborn, B.P.

    1983-01-01

    In neutron protein crystallography, the use of position-sensitive detectors controlled by a modern data-acquisition system permits new approaches to data-collection strategies. Instead of dealing with conventional scans, like the theta-2theta scan, that provide an integrated intensity as a function of a rotational parameter, the computer-linked counter can be used to produce a three-dimensional reflection profile. As the crystal steps (δ#betta#) through a reflection, the observed data for each step are stored in an external memory as a function of extent in 2theta and height (y) of a reflection. In this space, the reflection will be a three-dimensional distribution with dimensions determined by such basic geometrical conditions as δlambda, crystal size, mosaic spread, counter-resolution, and beam-collimation parameters. Knowledge of the interaction of these basic parameters will allow the design of optimal beam optics and will permit the delineation of the reflection from the background and permit, therefore, an accurate intensity determination. (Auth.)

  7. Optimal design of a high accuracy photoelectric auto-collimator based on position sensitive detector

    Science.gov (United States)

    Yan, Pei-pei; Yang, Yong-qing; She, Wen-ji; Liu, Kai; Jiang, Kai; Duan, Jing; Shan, Qiusha

    2018-02-01

    A kind of high accuracy Photo-electric auto-collimator based on PSD was designed. The integral structure composed of light source, optical lens group, Position Sensitive Detector (PSD) sensor, and its hardware and software processing system constituted. Telephoto objective optical type is chosen during the designing process, which effectively reduces the length, weight and volume of the optical system, as well as develops simulation-based design and analysis of the auto-collimator optical system. The technical indicators of auto-collimator presented by this paper are: measuring resolution less than 0.05″; a field of view is 2ω=0.4° × 0.4° measuring range is +/-5' error of whole range measurement is less than 0.2″. Measuring distance is 10m, which are applicable to minor-angle precise measuring environment. Aberration analysis indicates that the MTF close to the diffraction limit, the spot in the spot diagram is much smaller than the Airy disk. The total length of the telephoto lens is only 450mm by the design of the optical machine structure optimization. The autocollimator's dimension get compact obviously under the condition of the image quality is guaranteed.

  8. Imaging the electron transfer reaction of Ne2+ with Ar using position-sensitive coincidence spectroscopy

    International Nuclear Information System (INIS)

    Harper, Sarah M; Hu Wanping; Price, Stephen D

    2002-01-01

    A new experiment, employing position-sensitive detection coupled with time-of-flight mass spectrometry, has been used to investigate the single-electron transfer reaction between Ne 2+ and Ar by detecting the resulting pairs of singly charged ions in coincidence. The experimental technique allows the determination of the individual velocity vectors of the ionic products, in the centre-of-mass frame, for each reactive event detected. The experiments show that forward scattering dominates the reactivity, although a bimodal angular distribution is apparent. In addition, the spectra show that at laboratory frame collision energies from 4-14 eV the reactivity is dominated by Ne 2+ (2p 4 , 3 P) accepting an electron from an argon atom to form the ground state of Ne + together with an Ar + ion in an excited electronic level, predominantly arising from the Ar + (3s 2 3p 4 3d) configuration. The form of this reactivity, and the differences between the reactivity observed in these experiments and those performed at higher collision energies, are well reproduced by Landau-Zener theory

  9. An ancient form of position-sensitive detector - the individual counter array

    International Nuclear Information System (INIS)

    Hewat, A.W.

    1983-01-01

    Large position sensitive detectors (PSDs) have been very successful as high efficiency neutron powder diffractometers. Complete powder patterns can be obtained within minutes, making possible real-time measurements of structural changes accompanying chemical and electrochemical reactions. The angular resolution of such machines is determined by the diameter of the sample, and not simply by the resolution of the detector itself. It is argued that since sample diameters are usually 5mm to 10mm, it is possible to use an array of individual counters of similar diameter rather than a true PSD. Such a low to medium resolution individual counter array (ICA) can be made more efficient than the true PSD, produces an identical diffraction pattern, and has several practical advantages, including covering a greater solid angle. For high resolution powder diffraction, it has already been demonstrated that an ICA, in this case associated with Soller collimators, is again the most efficient solution. This is because the sample volume (and intensity) of a high resolution PSD decreases quadratically with the diameter of the sample. The only alternative to very small samples would be a large sample-detector distance, and then large vertical divergences cannot be achieved because of mechanical limitations on gas-filled PSD apertures; again intensity is lost. The resolution and efficiency of the ICA are discussed. (author)

  10. High resolution multiple sampling ionization chamber (MUSIC) sensitive to position coordinates

    International Nuclear Information System (INIS)

    Petrascu, H.; Kumagai, H.; Tanihata, I.; Petrascu, M.

    1999-01-01

    A new type of MUSIC sensitive to position coordinates is reported. The development of the first version of this type of chamber is based on the principles presented by Badhwar in 1973. The present detector will be used in experiments on fusion by using radioactive beams. This chamber due to the high resolution is suitable to identification and tracking of low Z particles. One of our goals, when we started this work, was to reduce as much as possible the Z value of particles that can be 'seen' by an ionization chamber. The resolution of the chamber was significantly improved by connecting the preamplifiers directly to the MUSIC's pads. These preamplifiers are able to work in vacuum and very low gas pressure. In this way the value of signal to noise ratio was increased by a factor of ∼10. The detector is of Frisch grid type, with the anode split into 10 active pads. It is the first model of a MUSIC with the field shared between the position grid and the anode pads. The Frisch grid was necessary because the detector is originally designed for very accurate energy measurements and particle identification. A drawing of this detector is shown. The detector itself consists of four main parts. The first one is the constant field-gradient cage, sandwiched in between the cathode and the Frisch grid. The second is the Frisch grid. The third is the position grid located under the Frisch grid. The last one is the plate with the anode pads. The cage is made of 100 μm Cu-Be wires. Every wire was tensioned with a weight representing half of its breaking limit. The Frisch grid was done on an aluminium frame, on which 20 μm W wires spaced 0.3 mm, were wound. For the position grid, 10 groups of 20 μm gold plated W wires have been used. Each group consisted of 5 wires spaced 0.9 mm and connected in parallel. The anode pads 7.8 x 60 mm 2 were perpendicular to the beam direction. Each pad and each of the position wire groups were connected to a preamplifier. The energy resolution

  11. Modulation of Quorum Sensing in a Gram-Positive Pathogen by Linear Molecularly Imprinted Polymers with Anti-infective Properties.

    Science.gov (United States)

    Motib, Anfal; Guerreiro, Antonio; Al-Bayati, Firas; Piletska, Elena; Manzoor, Irfan; Shafeeq, Sulman; Kadam, Anagha; Kuipers, Oscar; Hiller, Luisa; Cowen, Todd; Piletsky, Sergey; Andrew, Peter W; Yesilkaya, Hasan

    2017-12-22

    We describe the development, characterization, and biological testing of a new type of linear molecularly imprinted polymer (LMIP) designed to act as an anti-infective by blocking the quorum sensing (QS) mechanism and so abrogating the virulence of the pathogen Streptococcus pneumoniae. The LMIP is prepared (polymerized) in presence of a template molecule, but unlike in traditional molecular imprinting approaches, no cross-linker is used. This results in soluble low-molecular-weight oligomers that can act as a therapeutic agent in vitro and in vivo. The LMIP was characterized by mass spectrometry to determine its monomer composition. Fragments identified were then aligned along the peptide template by computer modeling to predict the possible monomer sequence of the LMIP. These findings provide a proof of principle that LMIPs can be used to block QS, thus setting the stage for the development of LMIPs a novel drug-discovery platform and class of materials to target Gram-positive pathogens. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients

    Directory of Open Access Journals (Sweden)

    Pivatelli Flávio

    2012-10-01

    Full Text Available Abstract Background Decreased heart rate variability (HRV is related to higher morbidity and mortality. In this study we evaluated the linear and nonlinear indices of the HRV in stable angina patients submitted to coronary angiography. Methods We studied 77 unselected patients for elective coronary angiography, which were divided into two groups: coronary artery disease (CAD and non-CAD groups. For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 40 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal], NN50 [total number of adjacent RR intervals with a difference of duration greater than 50ms] and RMSSD [root-mean square of differences] and frequency domains ultra-low frequency (ULF ≤ 0,003 Hz, very low frequency (VLF 0,003 – 0,04 Hz, low frequency (LF (0.04–0.15 Hz, and high frequency (HF (0.15–0.40 Hz as well as the ratio between LF and HF components (LF/HF. In relation to the nonlinear indices we evaluated SD1, SD2, SD1/SD2, approximate entropy (−ApEn, α1, α2, Lyapunov Exponent, Hurst Exponent, autocorrelation and dimension correlation. The definition of the cutoff point of the variables for predictive tests was obtained by the Receiver Operating Characteristic curve (ROC. The area under the ROC curve was calculated by the extended trapezoidal rule, assuming as relevant areas under the curve ≥ 0.650. Results Coronary arterial disease patients presented reduced values of SDNN, RMSSD, NN50, HF, SD1, SD2 and -ApEn. HF ≤ 66 ms2, RMSSD ≤ 23.9 ms, ApEn ≤−0.296 and NN50 ≤ 16 presented the best discriminatory power for the presence of significant coronary obstruction. Conclusion We suggest the use of Heart Rate Variability Analysis in linear and nonlinear domains, for prognostic purposes in patients with stable angina pectoris, in view of their overall impairment.

  13. Depth of interaction resolution measurements for a high resolution PET detector using position sensitive avalanche photodiodes

    International Nuclear Information System (INIS)

    Yang Yongfeng; Dokhale, Purushottam A; Silverman, Robert W; Shah, Kanai S; McClish, Mickel A; Farrell, Richard; Entine, Gerald; Cherry, Simon R

    2006-01-01

    We explore dual-ended read out of LSO arrays with two position sensitive avalanche photodiodes (PSAPDs) as a high resolution, high efficiency depth-encoding detector for PET applications. Flood histograms, energy resolution and depth of interaction (DOI) resolution were measured for unpolished LSO arrays with individual crystal sizes of 1.0, 1.3 and 1.5 mm, and for a polished LSO array with 1.3 mm pixels. The thickness of the crystal arrays was 20 mm. Good flood histograms were obtained for all four arrays, and crystals in all four arrays can be clearly resolved. Although the amplitude of each PSAPD signal decreases as the interaction depth moves further from the PSAPD, the sum of the two PSAPD signals is essentially constant with irradiation depth for all four arrays. The energy resolutions were similar for all four arrays, ranging from 14.7% to 15.4%. A DOI resolution of 3-4 mm (including the width of the irradiation band which is ∼2 mm) was obtained for all the unpolished arrays. The best DOI resolution was achieved with the unpolished 1 mm array (average 3.5 mm). The DOI resolution for the 1.3 mm and 1.5 mm unpolished arrays was 3.7 and 4.0 mm respectively. For the polished array, the DOI resolution was only 16.5 mm. Summing the DOI profiles across all crystals for the 1 mm array only degraded the DOI resolution from 3.5 mm to 3.9 mm, indicating that it may not be necessary to calibrate the DOI response separately for each crystal within an array. The DOI response of individual crystals in the array confirms this finding. These results provide a detailed characterization of the DOI response of these PSAPD-based PET detectors which will be important in the design and calibration of a PET scanner making use of this detector approach

  14. Study of capillary tracking detectors with position-sensitive photomultiplier readout

    International Nuclear Information System (INIS)

    Cardini, A.; Cavasinni, V.; Di Girolamo, B.; Dolinsky, S.I.; Flaminio, V.; Golovkin, S.V.; Gorin, A.M.; Medvedkov, A.M.; Pyshev, A.I.; Tyukov, V.E.; Vasilchenko, V.G.; Zymin, K.V.

    1995-01-01

    Measurements have been carried out on light yield and attenuation length in glass capillaries filled with new liquid scintillators (LS) and compared with analogous measurements made on 0.5 mm diameter plastic fibres Kuraray SCSF-38 and 3HF. It is found that, at a distance of 1 m, the light output in the capillary filled with green LS based on 1-methylnaphthalene doped with a new dye 3M15 is greater by a factor of 2 to 3 than for plastic fibres. A tracking detector consisting of a capillary bundle read out by a 100 channel position-sensitive microchannel plate photomultiplier (2MCP-100) has been built and tested in the laboratory using a cosmic ray trigger. A comparison has been made between the performance of such a detector and that of a similar one, read out by a 96 channel Philips XP1724/A photomultiplier. It was found that a bundle made of 20μm diameter capillaries with a tapered end giving a magnification of 2.56, filled with the new IPN+3M15 liquid scintillator, read out by the 2MCP-100, provides a space resolution of σ=170μm, a two-track resolution of the same value and a hit density of n=1.9/mm for tracks crossing the detector at a distance of 20 cm from the photocathode. If the same detector is read out by the Philips XP1724/A, the space resolution becomes 200μm, the two-track resolution 600μm and the hit density n=1.7/mm. The worse performance in the latter case is caused by the larger crosstalk compared with that of the 2MCP-100 PSPM. The results indicate that a LS-filled capillary detector is a very promising device for fast fibre tracking. (orig.)

  15. Sensitivity Range Analysis of Infrared (IR) Transmitter and Receiver Sensor to Detect Sample Position in Automatic Sample Changer

    International Nuclear Information System (INIS)

    Syirrazie Che Soh; Nolida Yussup; Nur Aira Abdul Rahman; Maslina Ibrahim

    2016-01-01

    Sensitivity range of IR Transmitter and Receiver Sensor influences the effectiveness of the sensor to detect position of a sample. Then the purpose of this analysis is to determine the suitable design and specification the electronic driver of the sensor to gain appropriate sensitivity range for required operation. The related activities to this analysis cover electronic design concept and specification, calibration of design specification and evaluation on design specification for required application. (author)

  16. Our Expedition in Linear Neutral Platinum-Acetylide Complexes: The Preparation of Micro/nanostructure Materials, Complicated Topologies, and Dye-Sensitized Solar Cells.

    Science.gov (United States)

    Xu, Lin; Yang, Hai-Bo

    2016-06-01

    During the past few decades, the construction of various kinds of platinum-acetylide complexes has attracted considerable attention, because of their wide applications in photovoltaic cells, non-linear optics, and bio-imaging materials. Among these platinum-acetylide complexes, the linear neutral platinum-acetylide complexes, due to their attractive properties, such as well-defined linear geometry, synthetic accessibility, and intriguing photoproperties, have emerged as a rising star in this field. In this personal account, we will discuss how we entered the field of linear neutral platinum-acetylide chemistry and what we found in this field. The preparation of various types of linear neutral platinum-acetylide complexes and their applications in the areas of micro/nanostructure materials, complicated topologies, and dye-sensitized solar cells will be summarized in this account. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Development of Bundle Position-Wise Linear Model for Predicting the Pressure Tube Diametral Creep in CANDU Reactors

    International Nuclear Information System (INIS)

    Lee, Jae Yong; Na, Man Gyun

    2011-01-01

    Diametral creep of the pressure tube (PT) is one of the principal aging mechanisms governing the heat transfer and hydraulic degradation of a heat transport system. PT diametral creep leads to diametral expansion that affects the thermal hydraulic characteristics of the coolant channels and the critical heat flux. Therefore, it is essential to predict the PT diametral creep in CANDU reactors, which is caused mainly by fast neutron irradiation, reactor coolant temperature and so forth. The currently used PT diametral creep prediction model considers the complex interactions between the effects of temperature and fast neutron flux on the deformation of PT zirconium alloys. The model assumes that long-term steady-state deformation consists of separable, additive components from thermal creep, irradiation creep and irradiation growth. This is a mechanistic model based on measured data. However, this model has high prediction uncertainty. Recently, a statistical error modeling method was developed using plant inspection data from the Bruce B CANDU reactor. The aim of this study was to develop a bundle position-wise linear model (BPLM) to predict PT diametral creep employing previously measured PT diameters and HTS operating conditions. There are twelve bundles in a fuel channel and for each bundle, a linear model was developed by using the dependent variables, such as the fast neutron fluxes and the bundle temperatures. The training data set was selected using the subtractive clustering method. The data of 39 channels that consist of 80 percent of a total of 49 measured channels from Units 2, 3 and 4 were used to develop the BPLM models. The remaining 10 channels' data were used to test the developed BPLM models. The BPLM was optimized by the maximum likelihood estimation method. The developed BPLM to predict PT diametral creep was verified using the operating data gathered from the Units 2,3 and 4 in Korea. Two error components for the BPLM, which are the epistemic

  18. Evaluation of human skin tests for potential dermal irritant and contact sensitizing products: a position paper

    NARCIS (Netherlands)

    Loveren H van; Jong WH de; Garssen J; LPI

    1998-01-01

    Prediction of human cutaneous irritation and sensitization in view of hazard identification has primarily relied on the use of laboratory animals. Such studies in laboratory animals have been very instrumental in the detection of potential contact sensitizing agents. There are however many

  19. Calibration of the OPAL jet chamber with UV laser beams. Measurement of the beam position with position-sensitive silicon diodes (PSD)

    International Nuclear Information System (INIS)

    Koch, J.

    1990-03-01

    The OPAL jet chamber is calibrated with tracks produced by UV laser beams. Lateral effect diodes are used for monitoring the laser beam location in the detector. These position sensitive detectors locate the point of impact in two dimensions by the charge division method. Measurements on several diodes were carried out in order to calibrate these devices and to investigate to observed pin-cushion distortion. Using the telegraphers equation suitable expressions were obtained for describing the observed behaviour. It was shown that the magnetic field of OPAL as well as the UV laser wavelength and puls duration had no influence on the position information. (orig.)

  20. Modeling of a Low-Background Spectroscopic Position-Sensitive Neutron Detector

    Energy Technology Data Exchange (ETDEWEB)

    Postovarova, Daria; Evsenin, Alexey; Gorshkov, Igor; Kuznetsov, Andrey; Osetrov, Oleg; Vakhtin, Dmitry; Yurmanov, Pavel [V.G. Khlopin Radium Institute, 194021, 28, 2nd Murinsky pr., Saint-Petersburg (Russian Federation)

    2011-12-13

    A new low-background spectroscopic direction-sensitive neutron detector that would allow one to reduce the neutron background component in passive and active neutron detection techniques is proposed. The detector is based on thermal neutron detectors surrounded by a fast neutron scintillation detector, which serves at the same time as a neutron moderator. Direction sensitivity is achieved by coincidence/anticoincidence analysis between different parts of the scintillator. Results of mathematical modeling of several detector configurations are presented.

  1. Modeling of a Low-Background Spectroscopic Position-Sensitive Neutron Detector

    International Nuclear Information System (INIS)

    Postovarova, Daria; Evsenin, Alexey; Gorshkov, Igor; Kuznetsov, Andrey; Osetrov, Oleg; Vakhtin, Dmitry; Yurmanov, Pavel

    2011-01-01

    A new low-background spectroscopic direction-sensitive neutron detector that would allow one to reduce the neutron background component in passive and active neutron detection techniques is proposed. The detector is based on thermal neutron detectors surrounded by a fast neutron scintillation detector, which serves at the same time as a neutron moderator. Direction sensitivity is achieved by coincidence/anticoincidence analysis between different parts of the scintillator. Results of mathematical modeling of several detector configurations are presented.

  2. Partially slotted crystals for a high-resolution γ-camera based on a position sensitive photomultiplier

    International Nuclear Information System (INIS)

    Giokaris, N.; Loudos, G.; Maintas, D.; Karabarbounis, A.; Lembesi, M.; Spanoudaki, V.; Stiliaris, E.; Boukis, S.; Gektin, A.; Pedash, V.; Gayshan, V.

    2005-01-01

    Partially slotted crystals have been designed and constructed and have been used to evaluate the performance with respect to the spatial resolution of a γ-camera based on a position-sensitive photomultiplier. It is shown that the resolution obtained with such a crystal is only slightly worse than the one obtained with a fully pixelized one whose cost, however, is much higher

  3. A superconducting linear motor drive for a positive displacement bellows pump for use in the g-2 cryogenics system

    International Nuclear Information System (INIS)

    Green, M.A.

    1994-10-01

    Forced two-phase cooling of indirectly cooled magnets requires circulation of liquid helium through the magnet cooling channel. A bellows helium pump is one possible way of providing helium flow to a magnet cooling system. Since the bellows type of helium pump is immersed in liquid helium, a superconducting linear motor drive appears to be an attractive option. This report describes a linear motor drive that employs oriented permanent magnet materials such as samarium-cobalt as the stator magnet system and a superconducting loud speaker voice coil type of drive as the armature of the linear motor. This report examines drive motor requirements for a helium pump

  4. Application of a one-dimensional position-sensitive detector to a Kratky small-angle x-ray camera

    International Nuclear Information System (INIS)

    Russell, T.P.; Stein, R.S.; Kopp, M.K.; Zedler, R.E.; Hendricks, R.W.; Lin, J.S.

    1979-01-01

    A conventional Kratky small-angle collimation system has been modified to allow the use of a one-dimensional position-sensitive x-ray detector. The detector was designed specifically for use with a long-slit camera and has uniform sensitivity over the entire beam in the slit-length direction. Procedures for alignment of the collimation system are given, and a variety of tests of the performance of the system are presented. Among the latter are measurements of electronic noise and parasitic scattering as well as comparisons against samples which were also measured on other cameras. The good agreement of these comparisons demonstrates the success of the use of a position-sensitive detector with the Kratky collimation system

  5. Application of a one-dimensional position-sensitive detector to a Kratky small-angle x-ray camera

    Energy Technology Data Exchange (ETDEWEB)

    Russell, T.P.; Stein, R.S.; Kopp, M.K.; Zedler, R.E.; Hendricks, R.W.; Lin, J.S.

    1979-01-01

    A conventional Kratky small-angle collimation system has been modified to allow the use of a one-dimensional position-sensitive x-ray detector. The detector was designed specifically for use with a long-slit camera and has uniform sensitivity over the entire beam in the slit-length direction. Procedures for alignment of the collimation system are given, and a variety of tests of the performance of the system are presented. Among the latter are measurements of electronic noise and parasitic scattering as well as comparisons against samples which were also measured on other cameras. The good agreement of these comparisons demonstrates the success of the use of a position-sensitive detector with the Kratky collimation system.

  6. Position sensitive detection coupled to high-resolution time-of-flight mass spectrometry: Imaging for molecular beam deflection experiments

    International Nuclear Information System (INIS)

    Abd El Rahim, M.; Antoine, R.; Arnaud, L.; Barbaire, M.; Broyer, M.; Clavier, Ch.; Compagnon, I.; Dugourd, Ph.; Maurelli, J.; Rayane, D.

    2004-01-01

    We have developed and tested a high-resolution time-of-flight mass spectrometer coupled to a position sensitive detector for molecular beam deflection experiments. The major achievement of this new spectrometer is to provide a three-dimensional imaging (X and Y positions and time-of-flight) of the ion packet on the detector, with a high acquisition rate and a high resolution on both the mass and the position. The calibration of the experimental setup and its application to molecular beam deflection experiments are discussed

  7. Accretion of fat-free mass rather than fat mass in infancy is positively associated with linear growth in childhood

    DEFF Research Database (Denmark)

    Admassu Wossen, Bitiya; Ritz, Christian; Wells, Jonathan C K

    2018-01-01

    Background: We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied. Objective: This study...... examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children. Methods: In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth...... to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized...

  8. Musical training and empathy positively impact adults’ sensitivity to infant distress

    Directory of Open Access Journals (Sweden)

    Christine E Parsons

    2014-12-01

    Full Text Available Crying is the most powerful auditory signal of infant need. Adults’ ability to perceive and respond to crying is important for infant survival and in the provision of care. This study investigated a number of listener variables that might impact on adults’ perception of infant cry distress, namely parental status, musical training and empathy. Sensitivity to infant distress was tested using a previously validated task, which experimentally manipulated distress by varying the pitch of infant cries. Parents with musical training showed a significant advantage on this task when compared with parents without. The extent of the advantage was correlated with the amount of self-reported musical training. For non-parents, individual differences in empathy were associated with task performance, with higher empathy scores corresponding to greater sensitivity to infant distress. We suggest that sensitivity to infant distress can be impacted by a number of listener variables, and may be amenable to training.

  9. 78 FR 42982 - Submission for Review: Information Collection; Questionnaire for Non-Sensitive Positions (SF 85)

    Science.gov (United States)

    2013-07-18

    ... Government civilian or military positions, or positions in private entities performing work for the Federal... adjudication. The SF 85 is completed by civilian employees of the Federal Government, military personnel, and... Security Number and provide the results to OPM. Clarifying language was added to the Authorization for...

  10. A high resolution position sensitive X-ray MWPC for small angle X-ray diffraction

    International Nuclear Information System (INIS)

    Bateman, J.E.; Connolly, J.F.; Stephenson, R.; Tappern, G.J.

    1981-02-01

    A small sealed-off delay line readout MWPC X-ray detector has been designed and built for small angle X-ray diffraction applications. Featuring a sensitive area of 100 mm x 25 mm it yields a spatial resolution of 0.13 mm (standard deviation) with a high rate capability and good quantum efficiency for copper K radiation. (author)

  11. An overview of current developments in position-sensitive hybrid photon detectors and photo-multiplier tubes

    CERN Document Server

    Gys, Thierry

    1999-01-01

    Current developments in position-sensitive hybrid photon detectors and photo-multiplier tubes have stimulated increased interest from a variety of fields such as astronomy, biomedical imaging and high- energy physics. These devices are sensitive to single photons over a photon energy spectrum defined by the transmission of the optical entrance window and the photo-cathode type. Their spatial resolution ranges from a few millimeters for pad hybrid photon detectors and multi-anode photo-multiplier tubes down to a few tens of microns for pixel hybrid photon detectors and electron-bombarded charge-coupled devices. Basic technological and design aspects are assessed in this paper. (21 refs).

  12. Existence of 2m-1 Positive Solutions for Sturm-Liouville Boundary Value Problems with Linear Functional Boundary Conditions on the Half-Line

    Directory of Open Access Journals (Sweden)

    Yanmei Sun

    2012-01-01

    Full Text Available By using the Leggett-Williams fixed theorem, we establish the existence of multiple positive solutions for second-order nonhomogeneous Sturm-Liouville boundary value problems with linear functional boundary conditions. One explicit example with singularity is presented to demonstrate the application of our main results.

  13. Improving sensitivity of linear regression-based cell type-specific differential expression deconvolution with per-gene vs. global significance threshold.

    Science.gov (United States)

    Glass, Edmund R; Dozmorov, Mikhail G

    2016-10-06

    The goal of many human disease-oriented studies is to detect molecular mechanisms different between healthy controls and patients. Yet, commonly used gene expression measurements from blood samples suffer from variability of cell composition. This variability hinders the detection of differentially expressed genes and is often ignored. Combined with cell counts, heterogeneous gene expression may provide deeper insights into the gene expression differences on the cell type-specific level. Published computational methods use linear regression to estimate cell type-specific differential expression, and a global cutoff to judge significance, such as False Discovery Rate (FDR). Yet, they do not consider many artifacts hidden in high-dimensional gene expression data that may negatively affect linear regression. In this paper we quantify the parameter space affecting the performance of linear regression (sensitivity of cell type-specific differential expression detection) on a per-gene basis. We evaluated the effect of sample sizes, cell type-specific proportion variability, and mean squared error on sensitivity of cell type-specific differential expression detection using linear regression. Each parameter affected variability of cell type-specific expression estimates and, subsequently, the sensitivity of differential expression detection. We provide the R package, LRCDE, which performs linear regression-based cell type-specific differential expression (deconvolution) detection on a gene-by-gene basis. Accounting for variability around cell type-specific gene expression estimates, it computes per-gene t-statistics of differential detection, p-values, t-statistic-based sensitivity, group-specific mean squared error, and several gene-specific diagnostic metrics. The sensitivity of linear regression-based cell type-specific differential expression detection differed for each gene as a function of mean squared error, per group sample sizes, and variability of the proportions

  14. Sensitivity of equatorial Pacific and Indian Ocean watermasses to the position of the Indonesian Throughflow

    Science.gov (United States)

    Rodgers, Keith B.; Latif, Mojib; Legutke, Stephanie

    2000-09-01

    The sensitivity of the thermal structure of the equatorial Pacific and Indian Ocean pycnoclines to a model's representation of the Indonesian Straits connecting the two basins is investigated. Two integrations are performed using the global HOPE ocean model. The initial conditions and surface forcing for both cases are identical; the only difference between the runs is that one has an opening for the Indonesian Straits which spans the equator on the Pacific side, and the other has an opening which lies fully north of the equator. The resulting sensitivity throughout much of the upper ocean is greater than 0.5°C for both the equatorial Indian and Pacific. A realistic simulation of net Indonesian Throughflow (ITF) transport (measured in Sverdrups) is not sufficient for an adequate simulation of equatorial watermasses. The ITF must also contain a realistic admixture of northern and southern Pacific source water.

  15. A fast position sensitive photodetector based on a CsI reflective photocathode

    International Nuclear Information System (INIS)

    Arnold, R.; Christophel, E.; Guyonnet, J.L.

    1991-01-01

    A fast detector was built for UV photon detection that depends on a CsI sensitized pad cathode. The rapidity of the detector is compared with that of a more classical chamber filled with photosensitive gases such as TEA or TMAE. Estimates of the quantum yield of the photocathode at 160 and 200 nm are given. The performances obtained make it a good photodetector candidate to be operated at high luminosity accelerators. (author) 7 refs., 19 figs

  16. Robust approach to maximize the range and accuracy of force application in atomic force microscopes with nonlinear position-sensitive detectors

    International Nuclear Information System (INIS)

    Silva, E C C M; Vliet, K J van

    2006-01-01

    The atomic force microscope is used increasingly to investigate the mechanical properties of materials via sample displacement under an applied force. However, both the extent of forces attainable and the accuracy of those forces measurements are significantly limited by the optical lever configuration that is commonly used to infer nanoscale deflection of the cantilever. We present a robust and general approach to characterize and compensate for the nonlinearity of the position-sensitive optical device via data processing, requiring no modification of existing instrumentation. We demonstrate that application of this approach reduced the maximum systematic error on the gradient of a force-displacement response from 50% to 5%, and doubled the calibrated force application range. Finally, we outline an experimental protocol that optimizes the use of the quasi-linear range of the most commonly available optical feedback configurations and also accounts for the residual systematic error, allowing the user to benefit from the full detection range of these indirect force sensors

  17. Automatic control system of a linear actuator for positioning samples to neutron irradiation using low cost open-hardware boards

    International Nuclear Information System (INIS)

    Cunya, Eduardo; Chan, Renzo; Pacheco, Adison

    2015-01-01

    This paper describes the design criteria and implementation of an automatic control system based on embedded electronic circuits (microcontrollers) of different architectures (RISC, ARM) and open source framework software CanFestival, to develop user applications. Electronic devices are autonomous and support the functionality required for communication and remote control of the linear actuator. (author)

  18. Modulation of Quorum Sensing in a Gram Positive Pathogen by Linear Imprinted Copolymers with anti-Infective Properties

    NARCIS (Netherlands)

    Motib, Anfal; Guerreiro, Antonio; Al-Bayati, Firas; Piletska, Elena; Manzoor, Irfan; Shafeeq, Sulman; Kadam, Anagha; Kuipers, Oscar; Hiller, Luisa; Cowen, Todd; Piletsky, Sergey; Andrew, Peter; Yesilkaya, Hasan

    2017-01-01

    Here we describe the development, characterization and biological testing of a new type of linear molecularly imprinted polymer (LMIP) designed to act as anti-infective by blocking the quorum sensing (QS) mechanism and so preventing virulence of the pathogen Streptococcus pneumoniae. The LMIP is

  19. Sensitivity of peak positions to flight-path parameters in a deep-inelastic scattering neutron TOF spectrometer

    International Nuclear Information System (INIS)

    Gray, E.MacA.; Chatzidimitriou-Dreismann, C.A.; Blach, T.P.

    2012-01-01

    The effects of small changes in flight-path parameters (primary and secondary flight paths, detector angles), and of displacement of the sample along the beam axis away from its ideal position, are examined for an inelastic time-of-flight (TOF) neutron spectrometer, emphasising the deep-inelastic regime. The aim was to develop a rational basis for deciding what measured shifts in the positions of spectral peaks could be regarded as reliable in the light of the uncertainties in the calibrated flight-path parameters. Uncertainty in the length of the primary or secondary flight path has the least effect on the positions of the peaks of H, D and He, which are dominated by the accuracy of the calibration of the detector angles. This aspect of the calibration of a TOF spectrometer therefore demands close attention to achieve reliable outcomes where the position of the peaks is of significant scientific interest and is discussed in detail. The corresponding sensitivities of the position of peak of the Compton profile, J(y), to flight-path parameters and sample position are also examined, focusing on the comparability across experiments of results for H, D and He. We show that positioning the sample to within a few mm of the ideal position is required to ensure good comparability between experiments if data from detectors at high forward angles are to be reliably interpreted.

  20. Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs.

    Science.gov (United States)

    Bossu, Alexandre; Kostense, Amée; Beekman, Henriette D M; Houtman, Marien J C; van der Heyden, Marcel A G; Vos, Marc A

    2018-05-10

    Current inotropic agents in heart failure therapy associate with low benefit and significant adverse effects, including ventricular arrhythmias. Istaroxime, a novel Na + /K + -transporting ATPase inhibitor, also stimulates SERCA2a activity, which would confer improved inotropic and lusitropic properties with less proarrhythmic effects. We investigated hemodynamic, electrophysiological and potential proarrhythmic and antiarrhythmic effects of istaroxime in control and chronic atrioventricular block (CAVB) dogs sensitive to drug-induced Torsades de Pointes arrhythmias (TdP). In isolated normal canine ventricular cardiomyocytes, istaroxime (0.3-10 μM) evoked no afterdepolarizations and significantly shortened action potential duration (APD) at 3 and 10 μM. Istaroxime at 3 μg/kg/min significantly increased left ventricular (LV) contractility (dP/dt + ) and relaxation (dP/dt-) respectively by 81 and 94% in anesthetized control dogs (n = 6) and by 61 and 49% in anesthetized CAVB dogs (n = 7) sensitive to dofetilide-induced TdP. While istaroxime induced no ventricular arrhythmias in control conditions, only single ectopic beats occurred in 2/7 CAVB dogs, which were preceded by increase of short-term variability of repolarization (STV) and T wave alternans in LV unipolar electrograms. Istaroxime pre-treatment (3 μg/kg/min for 60 min) did not alleviate dofetilide-induced increase in repolarization and STV, and mildly reduced incidence of TdP from 6/6 to 4/6 CAVB dogs. In six CAVB dogs with dofetilide-induced TdP, administration of istaroxime (90 μg/kg/5 min) suppressed arrhythmic episodes in two animals. Taken together, inotropic and lusitropic properties of istaroxime in CAVB dogs were devoid of significant proarrhythmic effects in sensitive CAVB dogs, and istaroxime provides a moderate antiarrhythmic efficacy in prevention and suppression of dofetilide-induced TdP. Copyright © 2018. Published by Elsevier Ltd.

  1. Design and Performance Analysis of Laser Displacement Sensor Based on Position Sensitive Detector (PSD)

    International Nuclear Information System (INIS)

    Song, H X; Wang, X D; Ma, L Q; Cai, M Z; Cao, T Z

    2006-01-01

    By using PSD as sensitive element, and laser diode as emitting element, laser displacement sensor based on triangulation method has been widely used. From the point of view of design, sensor and its performance were studied. Two different sensor configurations were described. Determination of the dimension, sensing resolution and comparison of the two different configurations were presented. The factors affecting the performance of the laser displacement sensor were discussed and two methods, which can eliminate the affection of dark current and environment light, are proposed

  2. A detector system for two-dimensional, position-sensitive detection of neutrons and gamma quanta

    International Nuclear Information System (INIS)

    Scholz, A.

    1988-08-01

    While the well-known Anger Camera utilizes a large number of photomultiplier tubes, which are arranged in a regular array behind a scintillation crystal, the new detector system makes use of electron optics to transfer the scintillation image of a large scintillation crystal (Li-6-glass) onto a small position detector. Because of this, only few photodetectors are required for position readout, associated with only a small number of amplifier chains and a very simple position reconstruction algorithm. The reduced complexity of the readout electronics ultimately leads to an improved maintainability and reliability of the detector system. A prototype of the new detector system was built and tested. After giving an overview on already known and realized detector configurations, the basic considerations, which led to the final detector design, will be explained. Different methods of detector readout and position determination are discussed. Measurement results which were obtained with the prototype detector system are presented and explained by means of simulation calculations. (orig./HP) [de

  3. Positive detection of exfoliated colon cancer cells on linear stapler cartridges was associated with depth of tumor invasion and preoperative bowel preparation in colon cancer.

    Science.gov (United States)

    Ikehara, Kishiko; Endo, Shungo; Kumamoto, Kensuke; Hidaka, Eiji; Ishida, Fumio; Tanaka, Jun-Ichi; Kudo, Shin-Ei

    2016-08-31

    The aim of this study was to investigate exfoliated cancer cells (ECCs) on linear stapler cartridges used for anastomotic sites in colon cancer. We prospectively analyzed ECCs on linear stapler cartridges used for anastomosis in 100 colon cancer patients who underwent colectomy. Having completed the functional end-to-end anastomosis, the linear stapler cartridges were irrigated with saline, which was collected for cytological examination and cytological diagnoses were made by board-certified pathologists based on Papanicolaou staining. The detection rate of ECCs on the linear stapler cartridges was 20 %. Positive detection of ECCs was significantly associated with depth of tumor invasion (p = 0.012) and preoperative bowel preparation (p = 0.003). There were no marked differences between ECC-positive and ECC-negative groups in terms of the operation methods, tumor location, histopathological classification, and surgical margins. Since ECCs were identified on the cartridge of the linear stapler used for anastomosis, preoperative mechanical bowel preparation using polyethylene glycol solution and cleansing at anastomotic sites using tumoricidal agents before anastomosis may be necessary to decrease ECCs in advanced colon cancer.

  4. Optimal design of a double-sided linear motor with a multi-segmented trapezoidal magnet array for a high precision positioning system

    International Nuclear Information System (INIS)

    Lee, Moon G.; Gweon, Dae-Gab

    2004-01-01

    A comparative analysis is performed for linear motors adopting conventional and multi-segmented trapezoidal (MST) magnet arrays, respectively, for a high-precision positioning system. The proposed MST magnet array is a modified version of a Halbach magnet array. The MST array has trapezoidal magnets with variable shape and dimensions while the Halbach magnet array generally has a rectangular magnet with identical dimensions. We propose a new model that can describe the magnetic field resulting from the complex-shaped magnets. The model can be applied to both MST and conventional magnet arrays. Using the model, a design optimization of the two types of linear motors is performed and compared. The magnet array with trapezoidal magnets can produce more force than one with rectangular magnets when they are arrayed in a linear motor where there is a yoke with high permeability. After the optimization and comparison, we conclude that the linear motor with the MST magnet array can generate more actuating force per volume than the motor with the conventional array. In order to satisfy the requirements of next generation systems such as high resolution, high speed, and long stroke, the use of a linear motor with a MST array as an actuator in a high precision positioning system is recommended from the results obtained here

  5. Endocrine sensitivity of the receptor-positive T61 human breast carcinoma serially grown in nude mice

    DEFF Research Database (Denmark)

    Brünner, N; Spang-Thomsen, M; Skovgaard Poulsen, H

    1985-01-01

    A study was made on the effect of ovariectomy, 17 beta-oestradiol, and tamoxifen on the oestrogen and progesterone receptor-positive T61 human breast carcinoma grown in nude mice. The effect of the treatment was evaluated by the specific growth delay calculated on the basis of Gompertz growth cur...... but is not a sufficiently clear marker to allow prediction of the endocrine sensitivity of individual breast tumours....

  6. Position sensitive X-ray or X-ray detector and 3-D-tomography using same

    International Nuclear Information System (INIS)

    1975-01-01

    A fan-shaped beam of penetrating radiation, such as X-ray or γ-ray radiation, is directed through a slice of the body to be analyzed into a position sensitive detector for deriving a shadowgraph of transmission or absorption of the penetrating radiation by the body. A number of such shadowgraphs are obtained for different angles of rotation of the fan-shaped beam relative to the center of the slice being analyzed. The detected fan beam shadowgraph data is reordered into shadowgraph data corresponding to sets of parallel paths of radiation through the body. The reordered parallel path shadowgraph data is then convoluted in accordance with a 3-D reconstruction method by convolution in a computer to derive a 3-D reconstructed tomograph of the body under analysis. In a preferred embodiment, the position sensitive detector comprises a multiwire detector wherein the wires are arrayed parallel to the direction of the divergent penetrating rays to be detected. A focussed grid collimator is interposed between the body and the position sensitive detector for collimating the penetrating rays to be detected. The source of penetrating radiation is preferably a monochromatic source

  7. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Laboratory, Upton, Long Island, NY 11973 (United States); Huang, Xiaobiao, E-mail: xiahuang@slac.stanford.edu [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

    2016-08-21

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

  8. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, Xiaobiao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-08-01

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. Furthermore, the fitting results are used for lattice correction. Our method has been successfully demonstrated on the NSLS-II storage ring.

  9. Position sensitivity of the proposed segmented germanium detectors for the DESPEC project

    International Nuclear Information System (INIS)

    Khaplanov, A.; Tashenov, S.; Cederwall, B.

    2009-01-01

    The DESPEC HPGe array is a part of the NuSTAR project at FAIR, Germany. It is aimed at the spectroscopy of the stopped decaying exotic nuclei. Segmented γ-ray tracking detectors are proposed for this array in order to maximize detection efficiency and background suppression when searching for very rare events. Two types of detector modules-stacks of three 16-fold segmented planar crystals and 12- and 16-fold segmented clover detectors-have been investigated and compared from the point of view of the achievable position resolution using pulse shape analysis (PSA). To this end, detector signals from realistic γ-ray interactions have been calculated. These signals were treated by PSA in order to reconstruct the photon interaction locations. Comparing the initial interaction locations to the reconstructed ones, it was found that the double-sided strip planar detector yielded position reconstruction errors at least a factor 2 lower than the other detectors considered.

  10. Position sensitive photon detectors for nuclear physics, particle physics and healthcare applications

    International Nuclear Information System (INIS)

    Seitz, B

    2012-01-01

    Modern experiments in hadronic physics require detector systems capable of identifying and reconstructing all final-state particles and their momentum vectors. Imaging Cherenkov counters (RICH and DIRC) are frequently employed in nuclear and particle physics experiments. These detectors require high-rate, single-photon capable light detection system with sufficient granularity and position resolution. Several candidate systems are available, ranging from multi-anode photomultiplier tubes to micro-channel plate systems to silicon photomultipliers. Each of these detection solutions has particular advantages and disadvantages. Detailed studies of rate dependence, cross-talk, time-resolution and position resolution for a range of available photon detection solutions are presented. These properties make these photon detection systems ideal for radionuclide imaging applications. Cherenkov radiation can also be used for medical imaging applications. Two different applications using the Cherenkov effect for radionuclide imaging will be reviewed.

  11. Two-dimensional position-sensitive detectors for small-angle neutron scattering

    International Nuclear Information System (INIS)

    McElhaney, S.A.; Vandermolen, R.I.

    1990-05-01

    In this paper, various detectors available for small angle neutron scattering (SANS) are discussed, along with some current developments being actively pursued. A section has been included to outline the various methodologies of position encoding/decoding with discussions on trends and limitations. Computer software/hardware vary greatly from institute and experiment and only a general discussion is given to this area. 85 refs., 33 figs

  12. Output pulse-shapes of position-sensitive proportional counters using high resistance single wire

    International Nuclear Information System (INIS)

    Iwatani, Kazuo; Nishiyama, Fumitaka; Hasai, Hiromi

    1980-01-01

    The measurements and model analysis of the output pulse-shapes from a single wire proportional counter (SWPC) which has a high resistance anode are described. The characteristics of the observed pulse-shapes are determined by only one parameter which is a function of anode resistance and load resistance and they are reproduced by a simple model. Using this model, the methods for position read-out are discussed in a systematical way. (author)

  13. Time-of-flight position-sensitive x-ray detection

    International Nuclear Information System (INIS)

    Mowat, J.W.

    1981-01-01

    A new method for recording beam-foil time-of-flight data is described. A stationary, side-window, position-senstive proportional counter, oriented with anode wire parallel to the ion beam, views the decay in flight of excited ions through a Soller slit x-ray collimator. In contrast to the standard method, the exciter foil, placed within or upstream from the field of view, is not moved during the acquisition of a decay curve. Each point on the anode acts like an independent detector seeing a unique segment of the ion beam. The correspondence between the downstream distance at which an ion decays and the position along the anode at which the x-ray is detected makes a pulse-height spectrum of position pulses equivalent to a time-of-flight decay curve. Thus an entire decay curve can now be acquired without moving the foil. Increased efficiency is the most significant improvement over the standard method in which the radiation detector views only a small segment of the flight path at any one time. Experiments using translating foils are subject to a spurious dependence of x-ray intensity on foil position if the foil is non-uniform (or non-uniformly aged) and wobbles as it moves. This effect is eliminated here. Foil aging effects which influence excitation rates and introduce a slowly varying time dependence of the x-ray intensity are automatically normalized by this multichannel technique. The application of this method to metastable x-ray emitting states of low-Z ions are discussed

  14. Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma

    Science.gov (United States)

    Mai-Prochnow, Anne; Clauson, Maryse; Hong, Jungmi; Murphy, Anthony B.

    2016-12-01

    Cold atmospheric-pressure plasma (CAP) is a relatively new method being investigated for antimicrobial activity. However, the exact mode of action is still being explored. Here we report that CAP efficacy is directly correlated to bacterial cell wall thickness in several species. Biofilms of Gram positive Bacillus subtilis, possessing a 55.4 nm cell wall, showed the highest resistance to CAP, with less than one log10 reduction after 10 min treatment. In contrast, biofilms of Gram negative Pseudomonas aeruginosa, possessing only a 2.4 nm cell wall, were almost completely eradicated using the same treatment conditions. Planktonic cultures of Gram negative Pseudomonas libanensis also had a higher log10 reduction than Gram positive Staphylococcus epidermidis. Mixed species biofilms of P. aeruginosa and S. epidermidis showed a similar trend of Gram positive bacteria being more resistant to CAP treatment. However, when grown in co-culture, Gram negative P. aeruginosa was more resistant to CAP overall than as a mono-species biofilm. Emission spectra indicated OH and O, capable of structural cell wall bond breakage, were present in the plasma. This study indicates that cell wall thickness correlates with CAP inactivation times of bacteria, but cell membranes and biofilm matrix are also likely to play a role.

  15. Shear-Induced Phase Separation in Aqueous Polymer Solutions: Temperature-Sensitive Microgels and Linear Polymer Chains

    NARCIS (Netherlands)

    Stieger, M.A.; Richtering, W.

    2003-01-01

    The influence of shear flow on the phase separation of aqueous poly(N-isopropylacrylamide) (PNiPAM) microgel suspensions was investigated by means of rheo-turbidity and rheo-small angle neutron scattering (rheo-SANS) and compared to the behavior of linear PNiPAM macromolecules. The rheological

  16. Linear gate

    International Nuclear Information System (INIS)

    Suwono.

    1978-01-01

    A linear gate providing a variable gate duration from 0,40μsec to 4μsec was developed. The electronic circuity consists of a linear circuit and an enable circuit. The input signal can be either unipolar or bipolar. If the input signal is bipolar, the negative portion will be filtered. The operation of the linear gate is controlled by the application of a positive enable pulse. (author)

  17. The reliability of linear position transducer, force plate and combined measurement of explosive power-time variables during a loaded jump squat in elite athletes.

    Science.gov (United States)

    Hansen, Keir T; Cronin, John B; Newton, Michael J

    2011-03-01

    The purpose of this study was to determine the between day reliability of power-time measures calculated with data collected using the linear position transducer or the force plate independently, or a combination of the two technologies. Twenty-five male rugby union players performed three jump squats on two occasions one week apart. Ground reaction forces were measured via a force plate and position data were collected using a linear position transducer. From these data, a number of power-time variables were calculated for each method. The force plate, linear position transducer and a combined method were all found to be a reliable means of measuring peak power (ICC = 0.87-0.95, CV = 3.4%-8.0%). The absolute consistency of power-time measures varied between methods (CV = 8.0%-53.4%). Relative consistency of power-time measures was generally comparable between methods and measures, and for many variables was at an acceptable level (ICC = 0.77-0.94). Although a number of time-dependent power variables can be reliably calculated from data acquired from the three methods investigated, the reliability of a number of these measures is below that which is acceptable for use in research and for practical applications.

  18. Current status and requirements for position-sensitive detectors in medicine

    CERN Document Server

    Speller, R

    2002-01-01

    This review considers the current status of detector developments for medical imaging using ionising radiation. This field is divided into two major areas; the use of X-rays for transmission imaging and the use of radioactive tracers in emission imaging (nuclear medicine). Until recently, most detector developments were for applications in nuclear medicine. However, in the past 5 years new developments in large area, X-ray-sensitive detectors have meant that both application domains are equally served. In X-ray imaging, work in CT and mammography are chosen as examples of sensor developments. Photodiode arrays in multi-slice spiral CT acquisitions are described and for mammography the use of amorphous silicon flat panel arrays is considered. The latter is an excellent example where new detector developments have required a re-think of traditional imaging methods. In gamma-ray imaging the recent developments in small area, task-specific cameras are described. Their limitations and current proposals to overcome...

  19. Amazingly resilient Indigenous people! Using transformative learning to facilitate positive student engagement with sensitive material.

    Science.gov (United States)

    Jackson, Debra; Power, Tamara; Sherwood, Juanita; Geia, Lynore

    2013-12-01

    If health professionals are to effectively contribute to improving the health of Indigenous people, understanding of the historical, political, and social disadvantage that has lead to health disparity is essential. This paper describes a teaching and learning experience in which four Australian Indigenous academics in collaboration with a non-Indigenous colleague delivered an intensive workshop for masters level post-graduate students. Drawing upon the paedagogy of Transformative Learning, the objectives of the day included facilitating students to explore their existing understandings of Indigenous people, the impact of ongoing colonisation, the diversity of Australia's Indigenous people, and developing respect for alternative worldviews. Drawing on a range of resources including personal stories, autobiography, film and interactive sessions, students were challenged intellectually and emotionally by the content. Students experienced the workshop as a significant educational event, and described feeling transformed by the content, better informed, more appreciative of other worldviews and Indigenous resilience and better equipped to contribute in a more meaningful way to improving the quality of health care for Indigenous people. Where this workshop differs from other Indigenous classes was in the involvement of an Indigenous teaching team. Rather than a lone academic who can often feel vulnerable teaching a large cohort of non-Indigenous students, an Indigenous teaching team reinforced Indigenous authority and created an emotionally and culturally safe space within which students were allowed to confront and explore difficult truths. Findings support the value of multiple teaching strategies underpinned by the theory of transformational learning, and the potential benefits of facilitating emotional as well as intellectual student engagement when presenting sensitive material.

  20. Modern trends in position-sensitive neutron detectors development for condensed matter research

    International Nuclear Information System (INIS)

    Belushkin, A.V.

    2007-01-01

    Detecting neutrons is a more complicated task compared to the detection of ionizing particles or ionizing radiation. This is why the variety of neutron detectors is much more limited. Meanwhile, different types of neutron experiments pose specific and often contradictory requirements for detector characteristics. For experiments on the high-intensity neutron sources, the high counting rate is one of the key issues. This is very important, for example, for small-angle neutron scattering and neutron reflectometry. For other experiments, characteristics like detection efficiency, high position resolution, high time resolution, neutron/gamma discrimination, large-area imaging, or compactness, are very important. Today, the cost of the detector also became one of the most important factors. There is no single type of detector which satisfies all the above criteria. Therefore, compromise is inevitable and some of the characteristics are trade off in favor of others. The present report gives an overview of detector systems presently operating at the leading neutron scattering facilities as well as some development work around the globe

  1. Position sensitive plastic scintillating fibre-detectors for heavy ion detection

    Energy Technology Data Exchange (ETDEWEB)

    Scholl, Sebastian; Tscheuschner, Joachim; Paschalis, Stefanos; Aumann, Thomas; Scheit, Heiko [Institut fuer Kernphysik, Technische Universitaet Darmstadt (Germany)

    2016-07-01

    The R{sup 3}B (Reactions with Relativistic Radioactive Beams) experiment at FAIR will be able to perform kinematically complete measurements of reactions with relativistic heavy-ion beams up to 1 AGeV. In order to track the beam before the target and to determine the mass number of the scattered nucleus after the reaction, five fibre detectors with sizes between 10.24 x 10.24 cm{sup 2} and 120 x 80 cm{sup 2} are going to be built for the R{sup 3}B setup. These fibre detectors will provide x-y-position of the trajectory of charged particles after the reaction target. The light from the fibre detector is sensed using MPPCs (Multi Pixel Photon Counter). For the readout of the MPPCs we test different electronics. In this contribution we present results obtained using an α-source and a LED light source to generate light in the fibre and use the PADI-VFTX for readout.

  2. HbA1c Measured in Stored Erythrocytes Is Positively Linearly Associated with Mortality in Individuals with Diabetes Mellitus

    Science.gov (United States)

    Sluik, Diewertje; Boeing, Heiner; Montonen, Jukka; Kaaks, Rudolf; Lukanova, Annekatrin; Sandbaek, Annelli; Overvad, Kim; Arriola, Larraitz; Ardanaz, Eva; Saieva, Calogero; Grioni, Sara; Tumino, Rosario; Sacerdote, Carlotta; Mattiello, Amalia; Spijkerman, Annemieke M. W.; van der A, Daphne L.; Beulens, Joline W. J.; van Dieren, Susan; Nilsson, Peter M.; Groop, Leif C.; Franks, Paul W.; Rolandsson, Olov; Bueno-de-Mesquita, Bas; Nöthlings, Ute

    2012-01-01

    Introduction Observational studies have shown that glycated haemoglobin (HbA1c) is related to mortality, but the shape of the association is less clear. Furthermore, disease duration and medication may modify this association. This observational study explored the association between HbA1c measured in stored erythrocytes and mortality. Secondly, it was assessed whether disease duration and medication use influenced the estimates or were independently associated with mortality. Methods Within the European Prospective Investigation into Cancer and Nutrition a cohort was analysed of 4,345 individuals with a confirmed diagnosis of diabetes at enrolment. HbA1c was measured in blood samples stored up to 19 years. Multivariable Cox proportional hazard regression models for all-cause mortality investigated HbA1c in quartiles as well as per 1% increment, diabetes medication in seven categories of insulin and oral hypoglycaemic agents, and disease duration in quartiles. Results After a median follow-up of 9.3 years, 460 participants died. Higher HbA1c was associated with higher mortality: Hazard Ratio for 1%-increase was 1.11 (95% CI 1.06, 1.17). This association was linear (P-nonlinearity =0.15) and persistent across categories of medication use, disease duration, and co-morbidities. Compared with metformin, other medication types were not associated with mortality. Longer disease duration was associated with mortality, but not after adjustment for HbA1c and medication. Conclusion This prospective study showed that persons with lower HbA1c had better survival than those with higher HbA1c. The association was linear and independent of disease duration, type of medication use, and presence of co-morbidities. Any improvement of HbA1c appears to be associated with reduced mortality risk. PMID:22719972

  3. A novel resveratrol-salinomycin combination sensitizes ER-positive breast cancer cells to apoptosis.

    Science.gov (United States)

    Venkatadri, Rajkumar; Iyer, Anand Krishnan V; Kaushik, Vivek; Azad, Neelam

    2017-08-01

    Resveratrol is a dietary compound that has been widely reported for its anticancer activities. However, successful extrapolation of its effects to pre-clinical studies is met with limited success due to inadequate bioavailability. We investigated the potential of combination therapy to improve the efficacy of resveratrol in a more physiologically relevant dose range. The effect of resveratrol on canonical Wnt signaling was evaluated by Western blotting. Wnt modulators HLY78 (activator) and salinomycin (inhibitor) were evaluated in combination with resveratrol for their effect on breast cancer cell viability (MTT assay), cell cycle progression and apoptosis (Western blotting). Bliss independency model was used to evaluate combinatorial effects of resveratrol-salinomycin combination. Resveratrol downregulated canonical Wnt signaling proteins in treated breast cancer cells (MCF-7, MDA-MB-231 and MDA-MB-468) in the dose range of 50-200μM, which also affected cellular viability. However, at very low doses (0-50μM), resveratrol exhibited no cellular toxicity. Co-treatment with salinomycin significantly potentiated the anti-cancer effects of resveratrol, whereas HLY78 co-treatment had minimal effect. Bliss independency model revealed that Wnt inhibition synergistically potentiates the effects of resveratrol in MCF-7 and BT474 cells. Significantly downregulated canonical Wnt signaling proteins and marker of epithelial-mesenchymal transition (EMT), vimentin were observed in cells treated with resveratrol-salinomycin combination. Cell cycle arrest, caspase activation and apoptosis induction in cells treated with resveratrol-salinomycin combination further confirmed the efficacy of the combination. We report a novel resveratrol-salinomycin combination for targeting ER-positive breast cancer cells and present evidence for successful pre-clinical implementation of resveratrol. Copyright © 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban

  4. A primary scintillation gated high pressure position sensitive gas scintillation proportional counter (HPGSPC) for applications to x-ray astronomy

    International Nuclear Information System (INIS)

    Giarrusso, S.; Manzo, G.; Re, S.

    1985-01-01

    The authors describe a new instrument for x-ray astronomy. The instrument, based on a high pressure (5 atm.), xenon filled, position sensitive Gas Scintillation Proportional counter (HPGSPC) is expected to feature an energy resolution better than 4% at 60 keV, an angular resolution of approximately 20 arc-minutes over the full energy range (4 to 100 keV) and a field of view (FOV) of up to 30x30 degrees. A prototype flight unit of the gas cell on which the instrument is based is presently under technological development in the framework of the SAX project

  5. Electrophoresis of biomass decomposition products and position sensitive detection of the separated C-14 labelled substrates by plastic scintillator measurements

    International Nuclear Information System (INIS)

    Gruenwald, M.

    1985-12-01

    The subject of this work is separation and analysis of hydrothermally decomposed biomass solution by zone electrophoresis of charged hydrocarbon-borate complexes. The first half is dedicated to the electrophoresis. The second half describes a new evaluation method for chromatographs and electropherograms by position sensitive detection of C-14 β radiation in a 1 mm thick plastic scintillator. This method is applied to hydrothermally decomposed (U-C-14)-D glucose solutions and the results are compared to conventional chromatography. Performance numbers of the method are given. Extension to isoelectrically focused gels is also considered. (G.Q.)

  6. Design and Parametric Study of the Magnetic Sensor for Position Detection in Linear Motor Based on Nonlinear Parametric model order reduction.

    Science.gov (United States)

    Paul, Sarbajit; Chang, Junghwan

    2017-07-01

    This paper presents a design approach for a magnetic sensor module to detect mover position using the proper orthogonal decomposition-dynamic mode decomposition (POD-DMD)-based nonlinear parametric model order reduction (PMOR). The parameterization of the sensor module is achieved by using the multipolar moment matching method. Several geometric variables of the sensor module are considered while developing the parametric study. The operation of the sensor module is based on the principle of the airgap flux density distribution detection by the Hall Effect IC. Therefore, the design objective is to achieve a peak flux density (PFD) greater than 0.1 T and total harmonic distortion (THD) less than 3%. To fulfill the constraint conditions, the specifications for the sensor module is achieved by using POD-DMD based reduced model. The POD-DMD based reduced model provides a platform to analyze the high number of design models very fast, with less computational burden. Finally, with the final specifications, the experimental prototype is designed and tested. Two different modes, 90° and 120° modes respectively are used to obtain the position information of the linear motor mover. The position information thus obtained are compared with that of the linear scale data, used as a reference signal. The position information obtained using the 120° mode has a standard deviation of 0.10 mm from the reference linear scale signal, whereas the 90° mode position signal shows a deviation of 0.23 mm from the reference. The deviation in the output arises due to the mechanical tolerances introduced into the specification during the manufacturing process. This provides a scope for coupling the reliability based design optimization in the design process as a future extension.

  7. Characterization and linear array LA48 Commissioner for measuring the position of the multi leaf collimator; Caracterizacion y comisionado del linear array LA48 para medir el posicionamiento del colimador multilaminas

    Energy Technology Data Exchange (ETDEWEB)

    Conles Picos, I.; Cenizo de Castro, E.; Aparicio martin, A. R.; Barrio Lazo, F.; Cesteros Morante, M. J.

    2011-07-01

    The protocol of Quality Control of electron accelerators for medical use of SEFM proposed for multi leaf collimation system (MLC) to verify the positioning of the blades connect. To do this you must find a system with sufficient accuracy and precision and, if possible, easy to assemble and offers real-time results. One of these teams is the Linear Array of PTW-Freiburg (LA48), which consists of a row of 47 ionization chambers, of 0008 cc and 8 mm apart from each other. In this paper, we describe our process of characterization and LA48 commissioner. (Author)

  8. Front-end circuit for position sensitive silicon and vacuum tube photomultipliers with gain control and depth of interaction measurement

    International Nuclear Information System (INIS)

    Herrero, Vicente; Colom, Ricardo; Gadea, Rafael; Lerche, Christoph W.; Cerda, Joaquin; Sebastia, Angel; Benlloch, Jose M.

    2007-01-01

    Silicon Photomultipliers, though still under development for mass production, may be an alternative to traditional Vacuum Photomultipliers Tubes (VPMT). As a consequence, electronic front-ends initially designed for VPMT will need to be modified. In this simulation, an improved architecture is presented which is able to obtain impact position and depth of interaction of a gamma ray within a continuous scintillation crystal, using either kind of PM. A current sensitive preamplifier stage with individual gain adjustment interfaces the multi-anode PM outputs with a current division resistor network. The preamplifier stage allows to improve front-end processing delay and temporal resolution behavior as well as to increase impact position calculation resolution. Depth of interaction (DOI) is calculated from the width of the scintillation light distribution, which is related to the sum of voltages in resistor network input nodes. This operation is done by means of a high-speed current mode scheme

  9. Sensitivity of the corneal-plane refractive compensation to change in power and axial position of an intraocular lens

    Directory of Open Access Journals (Sweden)

    W. F. Harris

    2009-12-01

    Full Text Available If an intraocular lens is displaced or if its power is changed what are the consequences for the refractive compensation of the eye?  Gaussian optics is used to obtain explicit formulae for the sensitivityof the corneal-plane refractive compensation (also called the refraction, refractive state, etc to change in power and axial displacement of a thin intraocular lens implanted in a simple eye.  In particular, for a pseudophakic Gullstrand simplified eye with intraocular lens placed 5 mm behind the cornea the sensitivity to errors in the power of the intraocular lens is about  71 . 0 − 71 for an intraocular lens of power   for an intraocular lens of power 20 D, that is, the refractive compensation decreases by about 0.71 dioptres per dioptre increase in the power of the intraocular lens.  More generally the sensitivity is approximately  ( m   0037 . 0 63 . 0 F − − 0.63 ( 003 . 0 63 . 0 − − (0.0037mF where FI is the power of the intraocular lens.  Also for Gullstrand’s simplified eye the sensitivity of refractive compensation to axial displacement of the intraocular lens is approximately linear in FI about  (64D FI, in fact.  That is, for each dioptre of the power of the intraocular lens the refractive compensation increases by about 0.064 dioptres per millimetre of axial displacement towards the retina. 

  10. High Dynamics and Precision Optical Measurement Using a Position Sensitive Detector (PSD in Reflection-Mode: Application to 2D Object Tracking over a Smart Surface

    Directory of Open Access Journals (Sweden)

    Ioan Alexandru Ivan

    2012-12-01

    Full Text Available When related to a single and good contrast object or a laser spot, position sensing, or sensitive, detectors (PSDs have a series of advantages over the classical camera sensors, including a good positioning accuracy for a fast response time and very simple signal conditioning circuits. To test the performance of this kind of sensor for microrobotics, we have made a comparative analysis between a precise but slow video camera and a custom-made fast PSD system applied to the tracking of a diffuse-reflectivity object transported by a pneumatic microconveyor called Smart-Surface. Until now, the fast system dynamics prevented the full control of the smart surface by visual servoing, unless using a very expensive high frame rate camera. We have built and tested a custom and low cost PSD-based embedded circuit, optically connected with a camera to a single objective by means of a beam splitter. A stroboscopic light source enhanced the resolution. The obtained results showed a good linearity and a fast (over 500 frames per second response time which will enable future closed-loop control by using PSD.

  11. Linear Dispersion Relation and Depth Sensitivity to Swell Parameters: Application to Synthetic Aperture Radar Imaging and Bathymetry

    Directory of Open Access Journals (Sweden)

    Valentina Boccia

    2015-01-01

    Full Text Available Long gravity waves or swell dominating the sea surface is known to be very useful to estimate seabed morphology in coastal areas. The paper reviews the main phenomena related to swell waves propagation that allow seabed morphology to be sensed. The linear dispersion is analysed and an error budget model is developed to assess the achievable depth accuracy when Synthetic Aperture Radar (SAR data are used. The relevant issues and potentials of swell-based bathymetry by SAR are identified and discussed. This technique is of particular interest for characteristic regions of the Mediterranean Sea, such as in gulfs and relatively close areas, where traditional SAR-based bathymetric techniques, relying on strong tidal currents, are of limited practical utility.

  12. Evaluation of prediction capability, robustness, and sensitivity in non-linear landslide susceptibility models, Guantánamo, Cuba

    Science.gov (United States)

    Melchiorre, C.; Castellanos Abella, E. A.; van Westen, C. J.; Matteucci, M.

    2011-04-01

    This paper describes a procedure for landslide susceptibility assessment based on artificial neural networks, and focuses on the estimation of the prediction capability, robustness, and sensitivity of susceptibility models. The study is carried out in the Guantanamo Province of Cuba, where 186 landslides were mapped using photo-interpretation. Twelve conditioning factors were mapped including geomorphology, geology, soils, landuse, slope angle, slope direction, internal relief, drainage density, distance from roads and faults, rainfall intensity, and ground peak acceleration. A methodology was used that subdivided the database in 3 subsets. A training set was used for updating the weights. A validation set was used to stop the training procedure when the network started losing generalization capability, and a test set was used to calculate the performance of the network. A 10-fold cross-validation was performed in order to show that the results are repeatable. The prediction capability, the robustness analysis, and the sensitivity analysis were tested on 10 mutually exclusive datasets. The results show that by means of artificial neural networks it is possible to obtain models with high prediction capability and high robustness, and that an exploration of the effect of the individual variables is possible, even if they are considered as a black-box model.

  13. SU-G-BRB-03: Assessing the Sensitivity and False Positive Rate of the Integrated Quality Monitor (IQM) Large Area Ion Chamber to MLC Positioning Errors

    Energy Technology Data Exchange (ETDEWEB)

    Boehnke, E McKenzie; DeMarco, J; Steers, J; Fraass, B [Cedars-Sinai Medical Center, Los Angeles, CA (United States)

    2016-06-15

    Purpose: To examine both the IQM’s sensitivity and false positive rate to varying MLC errors. By balancing these two characteristics, an optimal tolerance value can be derived. Methods: An un-modified SBRT Liver IMRT plan containing 7 fields was randomly selected as a representative clinical case. The active MLC positions for all fields were perturbed randomly from a square distribution of varying width (±1mm to ±5mm). These unmodified and modified plans were measured multiple times each by the IQM (a large area ion chamber mounted to a TrueBeam linac head). Measurements were analyzed relative to the initial, unmodified measurement. IQM readings are analyzed as a function of control points. In order to examine sensitivity to errors along a field’s delivery, each measured field was divided into 5 groups of control points, and the maximum error in each group was recorded. Since the plans have known errors, we compared how well the IQM is able to differentiate between unmodified and error plans. ROC curves and logistic regression were used to analyze this, independent of thresholds. Results: A likelihood-ratio Chi-square test showed that the IQM could significantly predict whether a plan had MLC errors, with the exception of the beginning and ending control points. Upon further examination, we determined there was ramp-up occurring at the beginning of delivery. Once the linac AFC was tuned, the subsequent measurements (relative to a new baseline) showed significant (p <0.005) abilities to predict MLC errors. Using the area under the curve, we show the IQM’s ability to detect errors increases with increasing MLC error (Spearman’s Rho=0.8056, p<0.0001). The optimal IQM count thresholds from the ROC curves are ±3%, ±2%, and ±7% for the beginning, middle 3, and end segments, respectively. Conclusion: The IQM has proven to be able to detect not only MLC errors, but also differences in beam tuning (ramp-up). Partially supported by the Susan Scott Foundation.

  14. Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells

    International Nuclear Information System (INIS)

    Baumann, Jan; Wong, Jason; Sun, Yan; Conklin, Douglas S.

    2016-01-01

    CHOP-dependent apoptosis as well as a partial activation of the ER stress response network via XBP1 and ATF6. This response appears to be a general feature of HER2/neu-positive breast cancer cells but not cells that overexpress only HER2/neu. Exogenous palmitate reduces HER2 and HER3 protein levels without changes in phosphorylation and sensitizes HER2/neu-positive breast cancer cells to treatment with the HER2-targeted therapy trastuzumab. Several studies have shown that HER2, FASN and fatty acid synthesis are functionally linked. Exogenous palmitate exerts its toxic effects in part through inducing ER stress, reducing HER2 expression and thereby sensitizing cells to trastuzumab. These data provide further evidence that HER2 signaling and fatty acid metabolism are highly integrated processes that may be important for disease development and progression. The online version of this article (doi:10.1186/s12885-016-2611-8) contains supplementary material, which is available to authorized users

  15. HIV symptom distress and anxiety sensitivity in relation to panic, social anxiety, and depression symptoms among HIV-positive adults.

    Science.gov (United States)

    Gonzalez, Adam; Zvolensky, Michael J; Parent, Justin; Grover, Kristin W; Hickey, Michael

    2012-03-01

    Although past work has documented relations between HIV/AIDS and negative affective symptoms and disorders, empirical work has only just begun to address explanatory processes that may underlie these associations. The current investigation sought to test the main and interactive effects of HIV symptom distress and anxiety sensitivity in relation to symptoms of panic disorder (PD), social anxiety disorder (SA), and depression among people with HIV/AIDS. Participants were 164 adults with HIV/AIDS (17.1% women; mean age, 48.40) recruited from AIDS service organizations (ASOs) in Vermont/New Hampshire and New York City. The sample identified as 40.9% white/Caucasian, 31.1% black, 22.0% Hispanic, and 6.1% mixed/other; with more than half (56.7%) reporting an annual income less than or equal to $10,000. Both men and women reported unprotected sex with men as the primary route of HIV transmission (64.4% and 50%, respectively). HIV symptom distress and anxiety sensitivity (AS) were significantly positively related to PD, SA, and depression symptoms. As predicted, there was a significant interaction between HIV symptom distress and anxiety sensitivity in terms of PD and SA symptoms, but not depressive symptoms. Results suggest that anxiety sensitivity and HIV symptom distress are clinically relevant factors to consider in terms of anxiety and depression among people living with HIV/AIDS. It may be important to evaluate these factors among patients with HIV/AIDS to identify individuals who may be at a particularly high risk for anxiety and depression problems. Limitations included recruitment from ASOs, cross-sectional self-report data, and lack of a clinical diagnostic assessment.

  16. Methodology to reduce 6D patient positional shifts into a 3D linear shift and its verification in frameless stereotactic radiotherapy

    Science.gov (United States)

    Sarkar, Biplab; Ray, Jyotirmoy; Ganesh, Tharmarnadar; Manikandan, Arjunan; Munshi, Anusheel; Rathinamuthu, Sasikumar; Kaur, Harpreet; Anbazhagan, Satheeshkumar; Giri, Upendra K.; Roy, Soumya; Jassal, Kanan; Kalyan Mohanti, Bidhu

    2018-04-01

    The aim of this article is to derive and verify a mathematical formulation for the reduction of the six-dimensional (6D) positional inaccuracies of patients (lateral, longitudinal, vertical, pitch, roll and yaw) to three-dimensional (3D) linear shifts. The formulation was mathematically and experimentally tested and verified for 169 stereotactic radiotherapy patients. The mathematical verification involves the comparison of any (one) of the calculated rotational coordinates with the corresponding value from the 6D shifts obtained by cone beam computed tomography (CBCT). The experimental verification involves three sets of measurements using an ArcCHECK phantom, when (i) the phantom was not moved (neutral position: 0MES), (ii) the position of the phantom shifted by 6D shifts obtained from CBCT (6DMES) from neutral position and (iii) the phantom shifted from its neutral position by 3D shifts reduced from 6D shifts (3DMES). Dose volume histogram and statistical comparisons were made between ≤ft and ≤ft . The mathematical verification was performed by a comparison of the calculated and measured yaw (γ°) rotation values, which gave a straight line, Y  =  1X with a goodness of fit as R 2  =  0.9982. The verification, based on measurements, gave a planning target volume receiving 100% of the dose (V100%) as 99.1  ±  1.9%, 96.3  ±  1.8%, 74.3  ±  1.9% and 72.6  ±  2.8% for the calculated treatment planning system values TPSCAL, 0MES, 3DMES and 6DMES, respectively. The statistical significance (p-values: paired sample t-test) of V100% were found to be 0.03 for the paired sample ≤ft and 0.01 for ≤ft . In this paper, a mathematical method to reduce 6D shifts to 3D shifts is presented. The mathematical method is verified by using well-matched values between the measured and calculated γ°. Measurements done on the ArcCHECK phantom also proved that the proposed methodology is correct. The post-correction of the

  17. Compton scatter in germanium and its effect on imaging with gamma-ray position-sensitive detectors

    International Nuclear Information System (INIS)

    Sherman, I.S.; Strauss, M.G.; Brenner, R.

    1978-01-01

    The spatial spread due to Compton scatter in Ge was measured to study the reduction in image contrast and signal-to-noise ratio (S/N) resulting from erroneous readout in Ge position-sensitive detectors. The step response revealing this spread was obtained by scanning with a 122 keV γ-ray beam across a boundary of two sectors of a slotted coaxial Ge(Li) detector that is 40 mm diameter by 22 mm long. The derived line-spread function at 140 keV (/sup 99m/Tc) exhibits much shorter but thicker tails than those due to scatter in tissue as observed with a NaI detector through 5.5 cm of scattering material. Convolutions of rectangular profiles of voids with the Ge(Li) line-spread function show marked deterioration in contrast for voids less than 10 mm across, which in turn results in even greater deterioration of the S/N. As a result, the contrast for voids in Ge images is only 20 to 30 percent higher than that in NaI and the S/N is only comparable for equal detector areas. The degradation in image contrast due to scatter in Ge detectors can be greatly reduced by either using thin detectors (approximately 5 mm), where scatter virtually does not exist, or by using thicker detectors and rejecting scatter electronically. To reduce the effects of scatter on the S/N as well as on contrast, the erroneous position readouts must actually be corrected. A more realizable approach to achieving the ultimate potential of Ge detectors may be a scanning array of discrete detectors (not position sensitive) in which readout is not affected by scatter

  18. Sensitivity analysis for linear structural equation models, longitudinal mediation with latent growth models and blended learning in biostatistics education

    Science.gov (United States)

    Sullivan, Adam John

    In chapter 1, we consider the biases that may arise when an unmeasured confounder is omitted from a structural equation model (SEM) and sensitivity analysis techniques to correct for such biases. We give an analysis of which effects in an SEM are and are not biased by an unmeasured confounder. It is shown that a single unmeasured confounder will bias not just one but numerous effects in an SEM. We present sensitivity analysis techniques to correct for biases in total, direct, and indirect effects when using SEM analyses, and illustrate these techniques with a study of aging and cognitive function. In chapter 2, we consider longitudinal mediation with latent growth curves. We define the direct and indirect effects using counterfactuals and consider the assumptions needed for identifiability of those effects. We develop models with a binary treatment/exposure followed by a model where treatment/exposure changes with time allowing for treatment/exposure-mediator interaction. We thus formalize mediation analysis with latent growth curve models using counterfactuals, makes clear the assumptions and extends these methods to allow for exposure mediator interactions. We present and illustrate the techniques with a study on Multiple Sclerosis(MS) and depression. In chapter 3, we report on a pilot study in blended learning that took place during the Fall 2013 and Summer 2014 semesters here at Harvard. We blended the traditional BIO 200: Principles of Biostatistics and created ID 200: Principles of Biostatistics and epidemiology. We used materials from the edX course PH207x: Health in Numbers: Quantitative Methods in Clinical & Public Health Research and used. These materials were used as a video textbook in which students would watch a given number of these videos prior to class. Using surveys as well as exam data we informally assess these blended classes from the student's perspective as well as a comparison of these students with students in another course, BIO 201

  19. Low-sensitivity, low-bounce, high-linearity current-controlled oscillator suitable for single-supply mixed-mode instrumentation system.

    Science.gov (United States)

    Hwang, Yuh-Shyan; Kung, Che-Min; Lin, Ho-Cheng; Chen, Jiann-Jong

    2009-02-01

    A low-sensitivity, low-bounce, high-linearity current-controlled oscillator (CCO) suitable for a single-supply mixed-mode instrumentation system is designed and proposed in this paper. The designed CCO can be operated at low voltage (2 V). The power bounce and ground bounce generated by this CCO is less than 7 mVpp when the power-line parasitic inductance is increased to 100 nH to demonstrate the effect of power bounce and ground bounce. The power supply noise caused by the proposed CCO is less than 0.35% in reference to the 2 V supply voltage. The average conversion ratio KCCO is equal to 123.5 GHz/A. The linearity of conversion ratio is high and its tolerance is within +/-1.2%. The sensitivity of the proposed CCO is nearly independent of the power supply voltage, which is less than a conventional current-starved oscillator. The performance of the proposed CCO has been compared with the current-starved oscillator. It is shown that the proposed CCO is suitable for single-supply mixed-mode instrumentation systems.

  20. BACTERIOLOGICAL STUDY OF COAGULASE-POSITIVE AND COAGULASE-NEGATIVE STAPHYLOCOCCI IN RELATION TO METHICILLIN SENSITIVITY TESTING

    Directory of Open Access Journals (Sweden)

    Padmanabham Yalangi

    2016-10-01

    Full Text Available BACKGROUND Staphylococcus aureus has long been recognised as an important pathogen in human disease. Staphylococci infection occurs regularly in hospitalised patients and has serious consequences despite antibiotic therapy. Shortly after introduction of methicillin after clinical use Methicillin-Resistant Staphylococcus Aureus (MRSA were identified in many countries and become one of the most common causes of nosocomial infections. The aim of the study is to know the methicillin sensitivity of both coagulase-negative and coagulase-positive staphylococci isolated from various samples. MATERIALS AND METHODS 100 strains of staphylococci both coagulase positive and coagulase negative were isolated in the Department of Microbiology from various clinical samples. They were confirmed by morphology, staining methods and by using standard bacteriological procedures and biochemical reactions. Antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion test. RESULTS Predominant species from pus were S. epidermidis (42.42% and from sputum S. haemolyticus (31.81% from blood S. haemolyticus (53.33%. 53% of strains produced beta-lactamase. Majority 47.22% by S. epidermidis from pus followed by S. haemolyticus 23.33% from pus. Beta-lactamase production was least from throat swab (5.55%. Out of 32 coagulase-positive staphylococci tested to methicillin 15 (46.87% were found to be sensitive, 17 (53.13% were found to be resistant. Out of 68 coagulase-negative staphylococci tested, 13 (19.11% were found to sensitive and 55 (80.88% were found to be resistant. 72% of strains were sensitive to novobiocin and 28% resistant to novobiocin. 43% showed drug resistance to 2 drugs. 14% to 3 drugs and 5 drugs. 6% of staphylococci sensitive to all the 10 drugs. CONCLUSION MRSA is a type of bacteria that is resistant to a number of widely used antibiotics. This means MRSA infections can be more difficult to treat than other bacterial infections. In recent years

  1. Simultaneous acquisition of X-ray spectra using a multi-wire, position-sensitive gas flow detector

    International Nuclear Information System (INIS)

    Beaven, Peter A.; Marmotti, Mauro; Kampmann, Reinhard; Knoth, Joachim; Schwenke, Heinrich

    2003-01-01

    A multi-wire, gas-filled position-sensitive detector has been developed for the simultaneous recording of wavelength-dispersed X-ray signals that enables X-ray fluorescence spectrometry with a limited multi-element capability in the low Z element range. Details of the modular construction of the detector are given. The detector performance was characterized using Al-Kα radiation and a variable slit system. The detector has been applied in a laboratory spectrometer equipped with an electron source and a double multilayer mirror device as the wavelength-dispersing element. Spectra from Al and Si obtained in the simultaneous acquisition mode show good agreement with calculations performed using a ray-tracing model

  2. Evaluation of the x-ray response of a position-sensitive microstrip detector with an integrated readout chip

    International Nuclear Information System (INIS)

    Rossington, C.; Jaklevic, J.; Haber, C.; Spieler, H.; Reid, J.

    1990-08-01

    The performance of an SVX silicon microstrip detector and its compatible integrated readout chip have been evaluated in response to Rh Kα x-rays (average energy 20.5 keV). The energy and spatial discrimination capabilities, efficient data management and fast readout rates make it an attractive alternative to the CCD and PDA detectors now being offered for x-ray position sensitive diffraction and EXAFS work. The SVX system was designed for high energy physics applications and thus further development of the existing system is required to optimize it for use in practical x-ray experiments. For optimum energy resolution the system noise must be decreased to its previously demonstrated low levels of 2 keV FWHM at 60 keV or less, and the data handling rate of the computer must be increased. New readout chips are now available that offer the potential of better performance. 15 refs., 7 figs

  3. Measurement of 18O + 10B fusion cross section and construction of a position sensitive ionization chamber

    International Nuclear Information System (INIS)

    Added, N.

    1987-01-01

    The 18 O + 10 B fusion reaction has been investigated within the bombarding energy range of 29,0 MeV lab 0 lab 0 angular range. For this purpose, a high resolution position sensitive ionization chamber has been developed and constructed. Experimental results compared to model predictions and experimental systematics found in the literature allows to reject compound nucleus limitation to the fusion cross section up to energies as high as five times the coulomb barrier. Statistical model fits to the residues elementary distributions reveal a quite difuse partial fusion cross section in the angular momentum space. Systematic analysis of fusion barrier height (V B ) and radius (R B ) for neighbouring nuclei point out the importance of the nuclear matter difuseness in the competition between the fusion and quasi-direct process. Calculations within this framework were performed. (author) [pt

  4. Use of a YAP:Ce matrix coupled to a position-sensitive photomultiplier for high resolution positron emission tomography

    International Nuclear Information System (INIS)

    Del Guerra, A.; Zavattini, G.; Notaristefani, F. de; Giganti, M.; Piffanelli, A.; Pani, R.; Turra, A.

    1996-01-01

    A new scintillation detector system has been designed for application in high resolution Positron Emission Tomography (PET). The detector is a bundle of small YAlO 3 :Ce (YAP) crystals closely packed (0.2 x 0.2 x 3.0 cm 3 ), coupled to a position sensitive photomultiplier tube (PSPMT). The preliminary results obtained for spatial resolution, time resolution, energy resolution and efficiency of two such detectors working in coincidence are presented. These are 1.2 mm for the FWHM spatial resolution, 2.0 ns for the FWHM time resolution and 20% for the FWHM energy resolution at 511 keV. The measured efficiency is (44 ± 3)% with a 150 keV threshold and (20 ± 2)% with a 300 keV threshold

  5. Spatial profile measurements of ion-confining potentials using novel position-sensitive ion-energy spectrometer arrays

    International Nuclear Information System (INIS)

    Yoshida, M.; Cho, T.; Hirata, M.; Ito, H.; Kohagura, J.; Yatsu, K.; Miyoshi, S.

    2003-01-01

    The first experimental demonstration of simultaneous measurements of temporally and spatially resolved ion-confining potentials phi c and end-loss-ion fluxes I ELA has been carried out during a single plasma discharge alone by the use of newly designed ion-energy-spectrometer arrays installed in both end regions of the GAMMA 10 tandem mirror. This position-sensitive ion-detector structure is proposed to obtain precise ion-energy spectra without any perturbations from simultaneously incident energetic electrons into the arrays. The relation between phi c and I ELA is physically interpreted in terms of Pastukhov's potential confinement theory. In particular, the importance of axisymmetric phi c formation is found for the plasma confinement

  6. Overexpression of GbWRKY1 positively regulates the Pi starvation response by alteration of auxin sensitivity in Arabidopsis.

    Science.gov (United States)

    Xu, Li; Jin, Li; Long, Lu; Liu, Linlin; He, Xin; Gao, Wei; Zhu, Longfu; Zhang, Xianlong

    2012-12-01

    Overexpression of a cotton defense-related gene GbWRKY1 in Arabidopsis resulted in modification of the root system by enhanced auxin sensitivity to positively regulate the Pi starvation response. GbWRKY1 was a cloned WRKY transcription factor from Gossypium barbadense, which was firstly identified as a defense-related gene and showed moderate similarity with AtWRKY75 from Arabidopsis thaliana. Overexpression of GbWRKY1 in Arabidopsis resulted in attenuated Pi starvation stress symptoms, including reduced accumulation of anthocyanin and impaired density of lateral roots (LR) in low Pi stress. The study also indicated that overexpression of GbWRKY1 caused plants constitutively exhibited Pi starvation response including increased development of LR, relatively high level of total P and Pi, high expression level of some high-affinity Pi transporters and phosphatases as well as enhanced accumulation of acid phosphatases activity during Pi-sufficient. It was speculated that GbWRKY1 may act as a positive regulator in the Pi starvation response as well as AtWRKY75. GbWRKY1 probably involves in the modulation of Pi homeostasis and participates in the Pi allocation and remobilization but do not accumulate more Pi in Pi-deficient condition, which was different from the fact that AtWRKY75 influenced the Pi status of the plant during Pi deprivation by increasing root surface area and accumulation of more Pi. Otherwise, further study suggested that the overexpression plants were more sensitive to auxin than wild-type and GbWRKY1 may partly influence the LPR1-dependent (low phosphate response 1) Pi starvation signaling pathway and was putatively independent of SUMO E3 ligase SIZ1 and PHR1 (phosphate starvation response 1) in response to Pi starvation.

  7. Influence of multiple sclerosis, age and degree of disability, in the position of the contrast sensitivity curve peak

    Directory of Open Access Journals (Sweden)

    A F Nunes

    2014-01-01

    Full Text Available Context: Contrast sensitivity (CS function is one of the most important tests available for evaluating visual impairment. Multiple sclerosis (MS can produce highly selective losses in visual function and psychophysical studies have demonstrated CS deficits for some spatial frequencies. Aims: This work studies the differences in CS between a group of controls and a group of MS patients, focusing on the location of the maximum sensitivity peak, shape of the curve, and determination of the most affected spatial frequencies. Materials and Methods: Using a sinusoidal stimulus the authors assessed CS function in 28 subjects with definitive relapsing remitting MS, and in 50 controls with acuities of 20/25 or better. The peaks of the CS curves were studied by fitting third degree polynomials to individual sets of data. Results: Compared with the control group, the CS function curve for MS subjects showed more deficits in extreme points (low- and high-spatial frequencies. Our results display significant CS losses, at the high-frequencies band level, in the beginning of the disease. When the disease progresses and the disabilities appear, there are greater losses at the low-frequencies band level. In average, the CS curve peaks for the MS group were shifted in relation to the control group. Conclusions: CS losses in the MS group suggest an association with ageing and disability level in the expanded disability status scale. The position of the CS function peak is influenced by MS, age, and degree of disability.

  8. Development of a highly sensitive current and position monitor with HTS squids and an HTS magnetic shield

    International Nuclear Information System (INIS)

    Watanabe, T.; Ikeda, T.; Kase, M.; Yano, Y.; Watanabe, S.; Sasaki, Y.; Kawaguchi, T.

    2005-01-01

    A highly sensitive current and position monitor with HTS (High-Temperature Superconducting) SQUIDs (Superconducting QUantum Interference Device) and an HTS magnetic shield for the measurement of the intensity of faint beams, such as a radioisotope beam, has been developed for the RIKEN RI beam factory project. The HTS magnetic shield and the HTS current sensor including the HTS SQUID are cooled by a low-vibration pulse-tube refrigerator. Both the HTS magnetic shield and the HTS current sensor were fabricated by dip-coating a thin Bi 2 -Sr 2 -Ca 2 -Cu 3 -O x (Bi-2223) layer on 99.9% MgO ceramic substrates. The HTS technology enables us to develop a system equipped with a downsized and highly sensitive current monitor. Recently, a prototype system was completed and installed in the beam transport line of the RIKEN Ring Cyclotron to measure the DC-current of high-energy heavy-ion beams. As a result, we succeeded in measuring the intensity of the 600 nA 40 Ar 17+ beam (95 MeV/u). We describe the present status of the monitor system and the results of the beam measurements. (author)

  9. Online Kidney Position Verification Using Non-Contrast Radiographs on a Linear Accelerator with on Board KV X-Ray Imaging Capability

    International Nuclear Information System (INIS)

    Willis, David J.; Kron, Tomas; Hubbard, Patricia; Haworth, Annette; Wheeler, Greg; Duchesne, Gillian M.

    2009-01-01

    The kidneys are dose-limiting organs in abdominal radiotherapy. Kilovoltage (kV) radiographs can be acquired using on-board imager (OBI)-equipped linear accelerators with better soft tissue contrast and lower radiation doses than conventional portal imaging. A feasibility study was conducted to test the suitability of anterior-posterior (AP) non-contrast kV radiographs acquired at treatment time for online kidney position verification. Anthropomorphic phantoms were used to evaluate image quality and radiation dose. Institutional Review Board approval was given for a pilot study that enrolled 5 adults and 5 children. Customized digitally reconstructed radiographs (DRRs) were generated to provide a priori information on kidney shape and position. Radiotherapy treatment staff performed online evaluation of kidney visibility on OBI radiographs. Kidney dose measured in a pediatric anthropomorphic phantom was 0.1 cGy for kV imaging and 1.7 cGy for MV imaging. Kidneys were rated as well visualized in 60% of patients (90% confidence interval, 34-81%). The likelihood of visualization appears to be influenced by the relative AP separation of the abdomen and kidneys, the axial profile of the kidneys, and their relative contrast with surrounding structures. Online verification of kidney position using AP non-contrast kV radiographs on an OBI-equipped linear accelerator appears feasible for patients with suitable abdominal anatomy. Kidney position information provided is limited to 2-dimensional 'snapshots,' but this is adequate in some clinical situations and potentially advantageous in respiratory-correlated treatments. Successful clinical implementation requires customized partial DRRs, appropriate imaging parameters, and credentialing of treatment staff.

  10. The 1 Repetition Maximum Mechanics of a High-Handle Hexagonal Bar Deadlift Compared With a Conventional Deadlift as Measured by a Linear Position Transducer.

    Science.gov (United States)

    Lockie, Robert G; Moreno, Matthew R; Lazar, Adrina; Risso, Fabrice G; Liu, Tricia M; Stage, Alyssa A; Birmingham-Babauta, Samantha A; Torne, Ibett A; Stokes, John J; Giuliano, Dominic V; Davis, DeShaun L; Orjalo, Ashley J; Callaghan, Samuel J

    2018-01-01

    Lockie, RG, Moreno, MR, Lazar, A, Risso, FG, Liu, TM, Stage, AA, Birmingham-Babauta, SA, Torne, IA, Stokes, JJ, Giuliano, DV, Davis, DL, Orjalo, AJ, and Callaghan, SJ. The 1 repetition maximum mechanics of a high-handle hexagonal bar deadlift compared with a conventional deadlift as measured by a linear position transducer. J Strength Cond Res 32(1): 150-161, 2018-The high-handle hexagonal bar deadlift (HHBD), a variation of the conventional deadlift (CD), is said to reduce the lift range of motion, which may change the mechanics of the lift. However, no research has investigated this. This study compared the mechanics between a 1 repetition maximum (1RM) CD and HHBD. Thirty-one strength-trained subjects (21 men, 10 women) completed a 1RM CD and HHBD. A linear position transducer measured lift distance, duration, and work; and peak and mean power, velocity, and force. The presence of a sticking region (SR) was determined for each lift. A repeated-measures analysis of variance (ANOVA) calculated differences between 1RM CD and HHBD mechanics. A one-way ANOVA compared the mechanics of each lift between subjects who exhibited an SR or not, and the SR between the CD and HHBD. Significance was set at p mechanics between subjects with or without an SR, and no differences in SR region distance or duration between the CD and HHBD. Greater force can be generated in the HHBD, which could have implications for strength-training adaptations over time.

  11. Measurement and analysis of neutron flux distribution of STACY heterogeneous core by position sensitive proportional counter. Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Murazaki, Minoru; Uno, Yuichi; Miyoshi, Yoshinori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    We have measured neutron flux distribution around the core tank of STACY heterogeneous core by position sensitive proportional counter (PSPC) to develop the method to measure reactivity for subcritical systems. The neutron flux distribution data in the position accuracy of {+-}13 mm have been obtained in the range of uranium concentration of 50g/L to 210g/L both in critical and in subcritical state. The prompt neutron decay constant, {alpha}, was evaluated from the measurement data of pulsed neutron source experiments. We also calculated distribution of neutron flux and {sup 3}He reaction rates at the location of PSPC by using continuous energy Monte Carlo code MCNP. The measurement data was compared with the calculation results. As results of comparison, calculated values agreed generally with measurement data of PSPC with Cd cover in the region above half of solution height, but the difference between calculated value and measurement data was large in the region below half of solution height. On the other hand, calculated value agreed well with measurement data of PSPC without Cd cover. (author)

  12. Measurement and analysis of neutron flux distribution of STACY heterogeneous core by position sensitive proportional counter. Contract research

    CERN Document Server

    Murazaki, M; Uno, Y

    2003-01-01

    We have measured neutron flux distribution around the core tank of STACY heterogeneous core by position sensitive proportional counter (PSPC) to develop the method to measure reactivity for subcritical systems. The neutron flux distribution data in the position accuracy of +-13 mm have been obtained in the range of uranium concentration of 50g/L to 210g/L both in critical and in subcritical state. The prompt neutron decay constant, alpha, was evaluated from the measurement data of pulsed neutron source experiments. We also calculated distribution of neutron flux and sup 3 He reaction rates at the location of PSPC by using continuous energy Monte Carlo code MCNP. The measurement data was compared with the calculation results. As results of comparison, calculated values agreed generally with measurement data of PSPC with Cd cover in the region above half of solution height, but the difference between calculated value and measurement data was large in the region below half of solution height. On the other hand, ...

  13. Improved abundance sensitivity of molecular ions in positive-ion APCI MS analysis of petroleum in toluene.

    Science.gov (United States)

    Kim, Young Hwan; Kim, Sunghwan

    2010-03-01

    Positive-ion atmospheric pressure chemical ionization (APCI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) analyses of petroleum sample were performed with higher sensitivity by switching the solvent composition from toluene and methanol or acetonitrile to a one-component system consisting only of toluene. In solvent blends, molecular ions were more abundant than were protonated ions with increasing percentages of toluene. In 100% toluene, the double-bond equivalence (DBE) distributions of molecular ions obtained by APCI MS for each compound class were very similar to those obtained in dopant assisted atmospheric pressure photo ionization (APPI) MS analyses. Therefore, it was concluded that charge-transfer reaction, which is important in toluene-doped APPI processes, also plays a major role in positive-ion APCI. In the DBE distributions of S(1), S(2), and SO heteroatom classes, a larger enhancement in the relative abundance of molecular ions at fairly specific DBE values was observed as the solvent was progressively switched to toluene. This enhanced abundance of molecular ions was likely dependent on molecular structure. Copyright 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

  14. Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution in Heliconius butterflies

    Science.gov (United States)

    Briscoe, Adriana D.; Bybee, Seth M.; Bernard, Gary D.; Yuan, Furong; Sison-Mangus, Marilou P.; Reed, Robert D.; Warren, Andrew D.; Llorente-Bousquets, Jorge; Chiao, Chuan-Chin

    2010-01-01

    The butterfly Heliconius erato can see from the UV to the red part of the light spectrum with color vision proven from 440 to 640 nm. Its eye is known to contain three visual pigments, rhodopsins, produced by an 11-cis-3-hydroxyretinal chromophore together with long wavelength (LWRh), blue (BRh) and UV (UVRh1) opsins. We now find that H. erato has a second UV opsin mRNA (UVRh2)—a previously undescribed duplication of this gene among Lepidoptera. To investigate its evolutionary origin, we screened eye cDNAs from 14 butterfly species in the subfamily Heliconiinae and found both copies only among Heliconius. Phylogeny-based tests of selection indicate positive selection of UVRh2 following duplication, and some of the positively selected sites correspond to vertebrate visual pigment spectral tuning residues. Epi-microspectrophotometry reveals two UV-absorbing rhodopsins in the H. erato eye with λmax = 355 nm and 398 nm. Along with the additional UV opsin, Heliconius have also evolved 3-hydroxy-DL-kynurenine (3-OHK)-based yellow wing pigments not found in close relatives. Visual models of how butterflies perceive wing color variation indicate this has resulted in an expansion of the number of distinguishable yellow colors on Heliconius wings. Functional diversification of the UV-sensitive visual pigments may help explain why the yellow wing pigments of Heliconius are so colorful in the UV range compared to the yellow pigments of close relatives lacking the UV opsin duplicate. PMID:20133601

  15. Observations of Local Positive Low Cloud Feedback Patterns and Their Role in Internal Variability and Climate Sensitivity

    Science.gov (United States)

    Yuan, Tianle; Oreopoulos, Lazaros; Platnick, Steven E.; Meyer, Kerry

    2018-05-01

    Modeling studies have shown that cloud feedbacks are sensitive to the spatial pattern of sea surface temperature (SST) anomalies, while cloud feedbacks themselves strongly influence the magnitude of SST anomalies. Observational counterparts to such patterned interactions are still needed. Here we show that distinct large-scale patterns of SST and low-cloud cover (LCC) emerge naturally from objective analyses of observations and demonstrate their close coupling in a positive local SST-LCC feedback loop that may be important for both internal variability and climate change. The two patterns that explain the maximum amount of covariance between SST and LCC correspond to the Interdecadal Pacific Oscillation and the Atlantic Multidecadal Oscillation, leading modes of multidecadal internal variability. Spatial patterns and time series of SST and LCC anomalies associated with both modes point to a strong positive local SST-LCC feedback. In many current climate models, our analyses suggest that SST-LCC feedback strength is too weak compared to observations. Modeled local SST-LCC feedback strength affects simulated internal variability so that stronger feedback produces more intense and more realistic patterns of internal variability. To the extent that the physics of the local positive SST-LCC feedback inferred from observed climate variability applies to future greenhouse warming, we anticipate significant amount of delayed warming because of SST-LCC feedback when anthropogenic SST warming eventually overwhelm the effects of internal variability that may mute anthropogenic warming over parts of the ocean. We postulate that many climate models may be underestimating both future warming and the magnitude of modeled internal variability because of their weak SST-LCC feedback.

  16. Evaluation of moderately cooled pure NaI as a scintillator for position-sensitive PET detectors

    International Nuclear Information System (INIS)

    Wear, J.A.; Karp, J.S.; Haigh, A.T.; Freifelder, R.

    1996-01-01

    A new evaluation of pure NaI has been performed to determine if moderate cooling would lead to better performance than that of existing, activated NaI(Tl) position-sensitive detectors, particularly at high countrates. Using a freezer, an initial effort was performed to cool the crystal assembly to -90 C (183 K). At this temperature, pure NaI has a decay constant of 35 nsec, a light output which is about 20% that of room temperature NaI(Tl), and an energy resolution of 15%. For the PET applications the signal of room temperature (25 C) NaI(Tl) is normally pulse clipped, reducing the light output to 40% of the unclipped signal and yielding an energy resolution of 10.5%. Since the long decay of NaI(Tl) causes it to suffer more significantly than pure NaI from pre-pulse pileup, the difference in energy resolution between the two crystals at high countrates will be reduced. Also, a significantly shorter trigger deadtime with pure NaI will lead to a reduction in coincidence deadtime losses in PET. Computer simulations of large-area crystals operating at high countrates have been performed to quantify their trigger deadtime behavior and position resolution as a function of light output and pulse decay time. Having gained experience with the practical issues of cooling large crystals, measurements of position resolution have been performed with a NaI bar detector of similar geometry to the NaI(Tl) detectors in use in the PENN-PET scanner

  17. Sensitivity analysis of the influence of the medium energy and initial fluence FWHM of electron determining a Bremsstrahlung photon spectrum of a linear accelerator

    International Nuclear Information System (INIS)

    Juste, B.; Miro, R.; Verdu, G.; Diez, S.; Campayo, J. M.

    2012-01-01

    A correct dose calculation in patient under radiotherapy treatments requires and accurate description of the radiation source. The main goal of the present work is to study the effects of initial electron beam characteristics on Monte Carlo calculated absorbed dose distribution for a 6 MeV linac photon beam. To that, we propose a methodology to determine the initial electron fluence before hitting the accelerator target for an Elektra Precisa medical linear accelerator. The method used for the electron radiation source description is based on a Software for Uncertainty and Sensitivity Analysis (SUSA) and Monte Carlo simulations using the MCNP5 transport code. This electron spectrum has been validated by means of comparison of its resulting depth dose curve in a water cube with experimental data being the mean difference below the 1%. (Author)

  18. Definition of a reference metrology network for the positioning of a large linear accelerator; Definition d'un reseau de reference metrologique pour le positionnement d'un grand accelerateur lineaire

    Energy Technology Data Exchange (ETDEWEB)

    Becker, F

    2003-12-15

    This thesis is a study of the Compact Linear Collider (CLIC) alignment system, a project of linear accelerator of about 30 km long of the European Organization for Nuclear Research (CERN). The pre-alignment tolerance on the transverse positions of the components of the CLIC linacs is typically ten microns over distances of 200 m. This research is a consequence of 10 years work, where several sets of special sensors dedicated to metrology have been adapted for the CLIC project. Most of these sensors deliver measurements linked to geometric references sensitive to gravity fluctuation. An important part of this work is therefore dedicated to study the gravity disruptions as a high level of accuracy is required. The parameters to take into account in the use of the hydrostatic leveling have thus been highlighted. A proposal of configuration of the system alignment based on a selection of sensors has also been given in this research. Computer models of different possible configurations have been presented. As the existing computing software was inappropriate, a new object oriented software package has been developed, to ensure future upgrades. An optimized configuration of the network has been defined from a set of simulations. Finally, due to problems in the use of hydrostatic leveling systems, a solution based on the use of a long laser beam as an alternative solution is discussed. (author)

  19. A sensitive one-step real-time PCR for detection of avian influenza viruses using a MGB probe and an internal positive control

    Directory of Open Access Journals (Sweden)

    Delogu Mauro

    2006-05-01

    Full Text Available Abstract Background Avian influenza viruses (AIVs are endemic in wild birds and their introduction and conversion to highly pathogenic avian influenza virus in domestic poultry is a cause of serious economic losses as well as a risk for potential transmission to humans. The ability to rapidly recognise AIVs in biological specimens is critical for limiting further spread of the disease in poultry. The advent of molecular methods such as real time polymerase chain reaction has allowed improvement of detection methods currently used in laboratories, although not all of these methods include an Internal Positive Control (IPC to monitor for false negative results. Therefore we developed a one-step reverse transcription real time PCR (RRT-PCR with a Minor Groove Binder (MGB probe for the detection of different subtypes of AIVs. This technique also includes an IPC. Methods RRT-PCR was developed using an improved TaqMan technology with a MGB probe to detect AI from reference viruses. Primers and probe were designed based on the matrix gene sequences from most animal and human A influenza virus subtypes. The specificity of RRT-PCR was assessed by detecting influenza A virus isolates belonging to subtypes from H1–H13 isolated in avian, human, swine and equine hosts. The analytical sensitivity of the RRT-PCR assay was determined using serial dilutions of in vitro transcribed matrix gene RNA. The use of a rodent RNA as an IPC in order not to reduce the efficiency of the assay was adopted. Results The RRT-PCR assay is capable to detect all tested influenza A viruses. The detection limit of the assay was shown to be between 5 and 50 RNA copies per reaction and the standard curve demonstrated a linear range from 5 to 5 × 108 copies as well as excellent reproducibility. The analytical sensitivity of the assay is 10–100 times higher than conventional RT-PCR. Conclusion The high sensitivity, rapidity, reproducibility and specificity of the AIV RRT-PCR with

  20. Design, construction, and in vivo feasibility of a positioning device for irradiation of mice brains using a clinical linear accelerator and intensity modulated radiation therapy.

    Science.gov (United States)

    Rancilio, Nicholas J; Dahl, Shaun; Athanasiadi, Ilektra; Perez-Torres, Carlos J

    2017-12-01

    The goal of this study was to design a positioning device that would allow for selective irradiation of the mouse brain with a clinical linear accelerator. We designed and fabricated an immobilization fixture that incorporates three functions: head stabilizer (through ear bars and tooth bar), gaseous anesthesia delivery and scavenging, and tissue mimic/bolus. Cohorts of five mice were irradiated such that each mouse in the cohort received a unique dose between 1000 and 3000 cGy. DNA damage immunohistochemistry was used to validate an increase in biological effect as a function of radiation dose. Mice were then followed with hematoxylin and eosin (H&E) and anatomical magnetic resonance imaging (MRI). There was evidence of DNA damage throughout the brain proportional to radiation dose. Radiation-induced damage at the prescribed doses, as depicted by H&E, appeared to be constrained to the white matter consistent with radiological observation in human patients. The severity of the damage correlated with the radiation dose as expected. We have designed and manufactured a device that allows us to selectively irradiate the mouse brain with a clinical linear accelerator. However, some off-target effects are possible with large prescription doses.

  1. On the use of the autocorrelation and covariance methods for feedforward control of transverse angle and position jitter in linear particle beam accelerators

    International Nuclear Information System (INIS)

    Barr, D.S.

    1994-01-01

    It is desired to design a predictive feedforward transverse jitter control system to control both angle and position jitter in pulsed linear accelerators. Such a system will increase the accuracy and bandwidth of correction over that of currently available feedback correction systems. Intrapulse correction is performed. An offline process actually ''learns'' the properties of the jitter, and uses these properties to apply correction to the beam. The correction weights calculated offline are downloaded to a real-time analog correction system between macropulses. Jitter data were taken at the Los Alamos National Laboratory (LANL) Ground Test Accelerator (GTA) telescope experiment at Argonne National Laboratory (ANL). The experiment consisted of the LANL telescope connected to the ANL ZGS proton source and linac. A simulation of the correction system using this data was shown to decrease the average rms jitter by a factor of two over that of a comparable standard feedback correction system. The system also improved the correction bandwidth

  2. On the use of the autocorrelation and covariance methods for feedforward control of transverse angle and position jitter in linear particle beam accelerators

    International Nuclear Information System (INIS)

    Barr, D.S.

    1993-01-01

    It is desired to design a predictive feedforward transverse jitter control system to control both angle and position jitter in pulsed linear accelerators. Such a system will increase the accuracy and bandwidth of correction over that of currently available feedback correction systems. Intrapulse correction is performed. An offline process actually open-quotes learnsclose quotes the properties of the jitter, and uses these properties to apply correction to the beam. The correction weights calculated offline are downloaded to a real-time analog correction system between macropulses. Jitter data were taken at the Los Alamos National Laboratory (LANL) Ground Test Accelerator (GTA) telescope experiment at Argonne National Laboratory (ANL). The experiment consisted of the LANL telescope connected to the ANL ZGS proton source and linac. A simulation of the correction system using this data was shown to decrease the average rms jitter by a factor of two over that of a comparable standard feedback correction system. The system also improved the correction bandwidth

  3. A study of an optimal technological solution for the electronics of particle position sensitive gas detectors (multiwire proportional chambers)

    International Nuclear Information System (INIS)

    Zojceski, Z.

    1997-01-01

    This work aims at optimizing the electronics for position sensitive gas detectors. The first part is a review of proportional chamber operation principles and presents the different possibilities for the architecture of the electronics. The second part involves electronic signal processing for best signal-to-noise ratio. We present a time-variant filter based on a second order base line restorer.It allows a simple pole-zero and tail cancellation at high counting rates. Also, various interpolating algorithms for cathode strip chambers have been studied. The last part reports the development of a complete electronic system, from the preamplifiers up to the readout and control interface, for the cathode strip chambers in the focal plane of the BBS Spectrometer at KVI, Holland. The system is based on application specific D-size VXI modules. In all modules, the 16-bit ADCs and FIFO memory are followed by a Digital Signal Processor, which performs data filtering and cathode induced charge interpolation. Very good analog noise performance is obtained in a multi-processor environment. (author)

  4. Novel single-cell mega-size chambers for electrochemical etching of panorama position-sensitive polycarbonate ion image detectors

    Science.gov (United States)

    Sohrabi, Mehdi

    2017-11-01

    A novel development is made here by inventing panorama single-cell mega-size electrochemical etching (MS-ECE) chamber systems for processing panorama position-sensitive mega-size polycarbonate ion image detectors (MS-PCIDs) of potential for many neutron and ion detection applications in particular hydrogen ions or proton tracks and images detected for the first time in polycarbonates in this study. The MS-PCID is simply a large polycarbonate sheet of a desired size. The single-cell MS-ECE invented consists of two large equally sized transparent Plexiglas sheets as chamber walls holding a MS-PCID and the ECE chamber components tightly together. One wall has a large flat stainless steel electrode (dry cell) attached to it which is directly in contact with the MS-PCID and the other wall has a rod electrode with two holes to facilitate feeding and draining out the etching solution from the wet cell. A silicon rubber washer plays the role of the wet cell to hold the etchant and the electrical insulator to isolate the dry cell from the wet cell. A simple 50 Hz-HV home-made generator provides an adequate field strength through the two electrodes across the MS-ECE chamber. Two panorama single-cell MS-ECE chamber systems (circular and rectangular shapes) constructed were efficiently applied to processing the MS-PCIDs for 4π ion emission image detection of different gases in particular hydrogen ions or protons in a 3.5 kJ plasma focus device (PFD as uniquely observed by the unaided eyes). The panorama MS-PCID/MS-ECE image detection systems invented are novel with high potential for many applications in particular as applied to 4π panorama ion emission angular distribution image detection studies in PFD space, some results of which are presented and discussed.

  5. A Hybrid Model through the Fusion of Type-2 Fuzzy Logic Systems and Sensitivity-Based Linear Learning Method for Modeling PVT Properties of Crude Oil Systems

    Directory of Open Access Journals (Sweden)

    Ali Selamat

    2012-01-01

    Full Text Available Sensitivity-based linear learning method (SBLLM has recently been used as a predictive tool due to its unique characteristics and performance, particularly its high stability and consistency during predictions. However, the generalisation capability of SBLLM is sometimes limited depending on the nature of the dataset, particularly on whether uncertainty is present in the dataset or not. Since it made use of sensitivity analysis in relation to the data sets used, it is surely very prone to being affected by the nature of the dataset. In order to reduce the effects of uncertainties in SBLLM prediction and improve its generalisation ability, this paper proposes a hybrid system through the unique combination of type-2 fuzzy logic systems (type-2 FLSs and SBLLM; thereafter the hybrid system was used to model PVT properties of crude oil systems. Type-2 FLS has been choosen in order to better handle uncertainties existing in datasets beyond the capability of type-1 fuzzy logic systems. In the proposed hybrid, the type-2 FLS is used to handle uncertainties in reservoir data so that the cleaned data from type-2 FLS is then passed to the SBLLM for training and then final prediction using testing dataset follows. Comparative studies have been carried out to compare the performance of the newly proposed T2-SBLLM hybrid system with each of the constituent type-2 FLS and SBLLM. Empirical results from simulation show that the proposed T2-SBLLM hybrid system has greatly improved upon the performance of SBLLM, while also maintaining a better performance above that of the type-2 FLS.

  6. Sensitivity of Surface Temperature to Oceanic Forcing via q-Flux Green’s Function Experiments. Part I: Linear Response Function

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Fukai; Lu, Jian; Garuba, Oluwayemi A.; Leung, Lai-Yung; Luo, Yiyong; Wan, Xiuquan

    2018-05-01

    This paper explores the use of linear response function (LRF) to relate the mean sea surface temperature (SST) response to prescribed ocean heat convergence (q-flux) forcings. Two methods for constructing the LRF based on the fluctuation-dissipation theorem (FDT) and Green’s function (GRF) are examined. A 900-year preindustrial simulation from the Community Earth System Model with a slab ocean (CESM-SOM) is used to estimate the LRF using FDT. For GRF, 106 pairs of CESM-SOM simulations with warm and cold q-flux patches are performed. FDT is found to have skill in estimating the SST response to a q-flux forcing when the local SST response is strong, but it fails in inverse estimation of the q-flux forcing for a given SST pattern. In contrast, GRF is shown to be reasonably accurate in estimating both SST response and q-flux forcing. Possible degradation in FDT may be attributed to insufficient data sampling, significant departures of the SST data from Gaussian, and the non-normality of the constructed operator. The accurately estimated GRF-based LRF is used to (i) generate a global surface temperature sensitivity map that shows the q-flux forcing in higher latitudes to be three to four times more effective than in low latitudes in producing global surface warming; (ii) identify the most excitable SST mode (neutral vector) resembling Interdecadal Pacific Oscillation; and (iii) estimate a time-invariant q-flux forcing needed for maintaining the GHG-induced SST warming pattern. The GRF experiments will be used to construct LRF for other variables to further explore climate sensitivities and feedbacks.

  7. Sensitivity and specificity of CT colonography for the detection of colonic neoplasia after positive faecal occult blood testing: systematic review and meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Plumb, Andrew A.; Pendse, Douglas A.; Taylor, Stuart A. [University College London, Centre for Medical Imaging, London (United Kingdom); Halligan, Steve [University College London, Centre for Medical Imaging, London (United Kingdom); University College London, University College Hospital, Centre for Medical Imaging, Podium Level 2, London (United Kingdom); Mallett, Susan [University of Oxford, Department of Primary Care Health Sciences, Oxford (United Kingdom)

    2014-05-15

    CT colonography (CTC) is recommended after positive faecal occult blood testing (FOBt) when colonoscopy is incomplete or infeasible. We aimed to estimate the sensitivity and specificity of CTC for colorectal cancer and adenomatous polyps following positive FOBt via systematic review. The MEDLINE, EMBASE, AMED and Cochrane Library databases were searched for CTC studies reporting sensitivity and specificity for colorectal cancer and adenomatous polyps. Included subjects had tested FOBt-positive by guaiac or immunochemical methods. Per-patient detection rates were summarized via forest plots. Meta-analysis of sensitivity and specificity was conducted using a bivariate random effects model and the average operating point calculated. Of 538 articles considered, 5 met inclusion criteria, describing results from 622 patients. Research study quality was good. CTC had a high per-patient average sensitivity of 88.8 % (95 % CI 83.6 to 92.5 %) for ≥6 mm adenomas or colorectal cancer, with low between-study heterogeneity. Specificity was both more heterogeneous and lower, at an average of 75.4 % (95 % CI 58.6 to 86.8 %). Few studies have investigated CTC in FOBt-positive individuals. CTC is sensitive at a ≥6 mm threshold but specificity is lower and variable. Despite the limited data, these results suggest that CTC may adequately substitute for colonoscopy when the latter is undesirable. (orig.)

  8. Sensitivity and specificity of CT colonography for the detection of colonic neoplasia after positive faecal occult blood testing: systematic review and meta-analysis

    International Nuclear Information System (INIS)

    Plumb, Andrew A.; Pendse, Douglas A.; Taylor, Stuart A.; Halligan, Steve; Mallett, Susan

    2014-01-01

    CT colonography (CTC) is recommended after positive faecal occult blood testing (FOBt) when colonoscopy is incomplete or infeasible. We aimed to estimate the sensitivity and specificity of CTC for colorectal cancer and adenomatous polyps following positive FOBt via systematic review. The MEDLINE, EMBASE, AMED and Cochrane Library databases were searched for CTC studies reporting sensitivity and specificity for colorectal cancer and adenomatous polyps. Included subjects had tested FOBt-positive by guaiac or immunochemical methods. Per-patient detection rates were summarized via forest plots. Meta-analysis of sensitivity and specificity was conducted using a bivariate random effects model and the average operating point calculated. Of 538 articles considered, 5 met inclusion criteria, describing results from 622 patients. Research study quality was good. CTC had a high per-patient average sensitivity of 88.8 % (95 % CI 83.6 to 92.5 %) for ≥6 mm adenomas or colorectal cancer, with low between-study heterogeneity. Specificity was both more heterogeneous and lower, at an average of 75.4 % (95 % CI 58.6 to 86.8 %). Few studies have investigated CTC in FOBt-positive individuals. CTC is sensitive at a ≥6 mm threshold but specificity is lower and variable. Despite the limited data, these results suggest that CTC may adequately substitute for colonoscopy when the latter is undesirable. (orig.)

  9. Novel liquid chromatography method based on linear weighted regression for the fast determination of isoprostane isomers in plasma samples using sensitive tandem mass spectrometry detection.

    Science.gov (United States)

    Aszyk, Justyna; Kot, Jacek; Tkachenko, Yurii; Woźniak, Michał; Bogucka-Kocka, Anna; Kot-Wasik, Agata

    2017-04-15

    A simple, fast, sensitive and accurate methodology based on a LLE followed by liquid chromatography-tandem mass spectrometry for simultaneous determination of four regioisomers (8-iso prostaglandin F 2α , 8-iso-15(R)-prostaglandin F 2α , 11β-prostaglandin F 2α , 15(R)-prostaglandin F 2α ) in routine analysis of human plasma samples was developed. Isoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Validation of method was performed by evaluation of the key analytical parameters such as: matrix effect, analytical curve, trueness, precision, limits of detection and limits of quantification. As a homoscedasticity was not met for analytical data, weighted linear regression was applied in order to improve the accuracy at the lower end points of calibration curve. The detection limits (LODs) ranged from 1.0 to 2.1pg/mL. For plasma samples spiked with the isoprostanes at the level of 50pg/mL, intra-and interday repeatability ranged from 2.1 to 3.5% and 0.1 to 5.1%, respectively. The applicability of the proposed approach has been verified by monitoring of isoprostane isomers level in plasma samples collected from young patients (n=8) subjected to hyperbaric hyperoxia (100% oxygen at 280kPa(a) for 30min) in a multiplace hyperbaric chamber. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. The noise analysis and optimum filtering techniques for a two-dimensional position sensitive orthogonal strip gamma ray detector employing resistive charge division

    International Nuclear Information System (INIS)

    Gerber, M.S.; Muller, D.W.

    1976-01-01

    The analysis of an orthogonal strip, two-dimensional position sensitive high purity germanium gamma ray detector is discussed. Position sensitivity is obtained by connecting each electrode strip on the detector to a resistor network. Charge, entering the network, divides in relation to the resistance between its entry point and the virtual earth points of the charge sensitive preamplifiers located at the end of each resistor network. The difference of the voltage pulses at the output of each preamplifier is proportional to the position at which the charge entered the resistor network and the sum of the pulse is proportional to the energy of the detected gamma ray. The analysis and spatial noise resolution is presented for this type of position sensitive detector. The results of the analysis show that the position resolution is proportional to the square root of the filter amplifier's output pulse time constant and that for energy measurement the resolution is maximized at the filter amplifier's noise corner time constant. The design of the electronic noise filtering system for the prototype gamma ray camera was based on the mathematical energy and spatial resolution equations. For the spatial channel a Gaussian trapezoidal filtering system was developed. Gaussian filtering was used for the energy channel. The detector noise model was verified by taking rms noise measurements of the filtered energy and spatial pulses from resistive readout charge dividing detectors. These measurements were within 10% of theory. (Auth.)

  11. A position sensitive detector using a NaI(Tl)/photomultiplier tube combination for the energy range 200 keV to 10 MeV

    International Nuclear Information System (INIS)

    Court, A.J.; Dean, A.J.; Yearworth, M.; Younis, F.; Chiappetti, L.; Perotti, F.; Villa, G.; Ubertini, P.; La Padula, C.

    1988-01-01

    The performance of the position sensitive detector for the ZEBRA low energy gamma-ray imaging telescope is described. The detector consists of 9 position sensitive NaI(Tl) elements each 5.8x5.0x56.0 cm viewed at either end of the long axis by 2 in. photomultiplier tubes. The total active area is 2470 cm 2 with an average positional resolution of 2.1 cm and energy resolution of 15% FWHM at 661.6 keV. The method of flight calibration is described together with the provision within the on-board electronics to correct for sources of error in the calculation of event energy loss and position. The results presented are obtained from the calibration phase of the ZEBRA telescope project. (orig.)

  12. Relationship between neighbourhood socioeconomic position and neighbourhood public green space availability: An environmental inequality analysis in a large German city applying generalized linear models.

    Science.gov (United States)

    Schüle, Steffen Andreas; Gabriel, Katharina M A; Bolte, Gabriele

    2017-06-01

    The environmental justice framework states that besides environmental burdens also resources may be social unequally distributed both on the individual and on the neighbourhood level. This ecological study investigated whether neighbourhood socioeconomic position (SEP) was associated with neighbourhood public green space availability in a large German city with more than 1 million inhabitants. Two different measures were defined for green space availability. Firstly, percentage of green space within neighbourhoods was calculated with the additional consideration of various buffers around the boundaries. Secondly, percentage of green space was calculated based on various radii around the neighbourhood centroid. An index of neighbourhood SEP was calculated with principal component analysis. Log-gamma regression from the group of generalized linear models was applied in order to consider the non-normal distribution of the response variable. All models were adjusted for population density. Low neighbourhood SEP was associated with decreasing neighbourhood green space availability including 200m up to 1000m buffers around the neighbourhood boundaries. Low neighbourhood SEP was also associated with decreasing green space availability based on catchment areas measured from neighbourhood centroids with different radii (1000m up to 3000 m). With an increasing radius the strength of the associations decreased. Social unequally distributed green space may amplify environmental health inequalities in an urban context. Thus, the identification of vulnerable neighbourhoods and population groups plays an important role for epidemiological research and healthy city planning. As a methodical aspect, log-gamma regression offers an adequate parametric modelling strategy for positively distributed environmental variables. Copyright © 2017 Elsevier GmbH. All rights reserved.

  13. Uncertainty and sensitivity analysis of the effect of the mean energy and FWHM of the initial electron fluence on the Bremsstrahlung photon spectra of linear accelerators

    International Nuclear Information System (INIS)

    Juste, B.; Miró, R.; Verdú, G.; Macián, R.

    2012-01-01

    A calculation of the correct dose in radiation therapy requires an accurate description of the radiation source because uncertainties in characterization of the linac photon spectrum are propagated through the dose calculations. Unfortunately, detailed knowledge of the initial electron beam parameters is not readily available, and many researchers adjust the initial electron fluence values by trial-and-error methods. The main goal of this work was to develop a methodology to characterize the fluence of initial electrons before they hit the tungsten target of an Elekta Precise medical linear accelerator. To this end, we used a Monte Carlo technique to analyze the influence of the characteristics of the initial electron beam on the distribution of absorbed dose from a 6 MV linac photon beam in a water phantom. The technique is based on calculations with Software for Uncertainty and Sensitivity Analysis (SUSA) and Monte Carlo simulations with the MCNP5 transport code. The free parameters used in the SUSA calculations were the mean energy and full-width-at-half-maximum (FWHM) of the initial electron distribution. A total of 93 combinations of these parameters gave initial electron fluence configurations. The electron spectra thus obtained were used in a simulation of the electron transport through the target of the linear accelerator, which produced different photon (Bremsstrahlung) spectra. The simulated photon spectra were compared with the 6-MV photon spectrum provided by the linac manufacturer (Elekta). This comparison revealed how the mean energy and FWHM of the initial electron fluence affect the spectrum of the generated photons. This study has made it possible to fine-tune the examined electron beam parameters to obtain the resulted absorbed doses with acceptable accuracy (error <1%). - Highlights: ► Mean energy and radial spread are important parameters for simulating the incident electron beam in radiation therapy. ► Errors in determining the electron

  14. Low incidence of minor BRAF V600 mutation-positive subclones in primary and metastatic melanoma determined by sensitive and quantitative real-time PCR

    DEFF Research Database (Denmark)

    Kielsgaard Kristensen, Thomas; Clemmensen, Ole; Hoejberg, Lise

    2013-01-01

    BRAF V600 mutation is an important biological marker for therapeutic guidance in melanoma, where mutation-positive cases are candidates for therapy targeting mutant B-Raf. Recent studies showing intratumor variation in BRAF mutation status have caused concern that sensitive mutation analysis can ...

  15. Performance of a position sensitive Si(Li) x-ray detector dedicated to Compton polarimetry of stored and trapped highly-charged ions

    International Nuclear Information System (INIS)

    Weber, G; Braeuning, H; Hess, S; Maertin, R; Spillmann, U; Stoehlker, Th

    2010-01-01

    We report on a novel two-dimensional position sensitive Si(Li) detector dedicated to Compton polarimetry of x-ray radiation arising from highly-charged ions. The performance of the detector system was evaluated in ion-atom collision experiments at the ESR storage ringe at GSI, Darmstadt. Based on the data obtained, the polarimeter efficiency is estimated in this work.

  16. Effect of refraction index and thickness of the light guide in the position-sensitive gamma-ray detector using compact PS-PMTs

    International Nuclear Information System (INIS)

    Inoue, K.; Saito, H.; Nagashima, Y.; Hyodo, T.; Nagai, Y.; Muramatsu, S.; Nagai, S.

    2000-01-01

    We constructed a position-sensitive gamma-ray detector consisting of an array of BGO scintillators, a light guide and compact PS-PMTs. The effects of refractive index and thickness of the light guide of a glass plate on the detector performance were investigated. A light guide with higher refractive index and smaller thickness is found better for a good spatial resolution.

  17. Cardiac biomarkers as sensitive tools to evaluate the impact of xenobiotics on amphibians: the effects of anionic surfactant linear alkylbenzene sulfonate (LAS).

    Science.gov (United States)

    Jones-Costa, Monica; Franco-Belussi, Lilian; Vidal, Felipe Augusto Pinto; Gongora, Nathália Penteado; Castanho, Luciano Mendes; Dos Santos Carvalho, Cleoni; Silva-Zacarin, Elaine Cristina Mathias; Abdalla, Fabio Camargo; Duarte, Iolanda Cristina Silveira; Oliveira, Classius De; de Oliveira, Cristiane Ronchi; Salla, Raquel Fernanda

    2018-04-30

    Amphibian populations have been experiencing a drastic decline worldwide. Aquatic contaminants are among the main factors responsible for this decline, especially in the aquatic environment. The linear alkylbenzene sulfonate (LAS) is of particular concern, since it represents 84% of the anionic surfactants' trade. In Brazil, the maximal LAS concentration allowed in fresh waters is 0.5mgL -1 , but its potential harmful effects in amphibians remain unknown. Therefore, this study aimed to analyze the effects of a sublethal concentration of LAS (0.5mgL -1 ) for 96h on sensitive cardiac biomarkers of bullfrog tadpoles, Lithobates catesbeianus (Shaw, 1802). For this, we measured the activity level (AL - % of animals), in situ heart rate (f H - bpm), relative ventricular mass (RVM - % of body mass), in vitro myocardial contractility and cardiac histology of the ventricles. Tadpoles' AL and f H decreased in LAS group. In contrast, the RVM increased, as a result of a hypertrophy of the myocardium, which was corroborated by the enlargement of the nuclear measures and the increase of myocytes' diameters. These cellular effects resulted in an elevation of the in vitro contractile force of ventricle strips. Acceleration in the contraction (TPT - ms) also occurred, although no alterations in the time to relaxation (THR -ms) were observed. Therefore, it can be concluded that even when exposed to an environmentally safe concentration, this surfactant promotes several alterations in the cardiac function of bullfrog tadpoles that can impair their development, making them more susceptible to predators and less competitive in terms of reproduction success. Thus, LAS concentrations that are considered safe by Brazilian by regulatory agencies must be revised in order to minimize a drastic impact over amphibian populations. This study demonstrates the relevance of employing cardiac biomarkers at different levels (e.g., morphological, physiological and cellular) to evaluate effects of

  18. Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction.

    Science.gov (United States)

    van Winkel, Mark; Peeters, Frenk; van Winkel, Ruud; Kenis, Gunter; Collip, Dina; Geschwind, Nicole; Jacobs, Nele; Derom, Catherine; Thiery, Evert; van Os, Jim; Myin-Germeys, Inez; Wichers, Marieke

    2014-06-01

    A previous study reported that social stress sensitivity is moderated by the brain-derived-neurotrophic-factor(Val66Met) (BDNF rs6265) genotype. Additionally, positive emotions partially neutralize this moderating effect. The current study aimed to: (i) replicate in a new independent sample of subjects with residual depressive symptoms the moderating effect of BDNF(Val66Met) genotype on social stress sensitivity, (ii) replicate the neutralizing impact of positive emotions, (iii) extend these analyses to other variations in the BDNF gene in the new independent sample and the original sample of non-depressed individuals. Previous findings were replicated in an experience sampling method (ESM) study. Negative Affect (NA) responses to social stress were stronger in "Val/Met" carriers of BDNF(Val66Met) compared to "Val/Val" carriers. Positive emotions neutralized the moderating effect of BDNF(Val66Met) genotype on social stress sensitivity in a dose-response fashion. Finally, two of four additional BDNF SNPs (rs11030101, rs2049046) showed similar moderating effects on social stress-sensitivity across both samples. The neutralizing effect of positive emotions on the moderating effects of these two additional SNPs was found in one sample. In conclusion, ESM has important advantages in gene-environment (GxE) research and may attribute to more consistent findings in future GxE research. This study shows how the impact of BDNF genetic variation on depressive symptoms may be explained by its impact on subtle daily life responses to social stress. Further, it shows that the generation of positive affect (PA) can buffer social stress sensitivity and partially undo the genetic susceptibility. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  19. Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis

    NARCIS (Netherlands)

    Hougardy, BMT; Maduro, JH; van der Zee, AGJ; de Groot, DJA; van den Heuvel, FAJ; de Vries, EGE; de Jong, S

    2006-01-01

    In cervical carcinogenesis, the p53 tumor suppressor pathway is disrupted by HPV (human papilloma virus) E6 oncogene expression. E6 targets p53 for rapid proteasome-mediated degradation. We therefore investigated whether proteasome inhibition by MG132 could restore wild-type p53 levels and sensitize

  20. Reflexive Positioning in a Politically Sensitive Situation: Dealing with the Threats of Researching the West Bank Settler Experience

    Science.gov (United States)

    Possick, Chaya

    2009-01-01

    For the past 7 years, the author has conducted qualitative research projects revolving around the experiences of West Bank settlers. The political situation in Israel in general, and the West Bank in particular, has undergone rapid and dramatic political, military, and social changes during this period. In highly politically sensitive situations…

  1. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters

    International Nuclear Information System (INIS)

    Carlson, David J.; Stewart, Robert D.; Semenenko, Vladimir A.

    2006-01-01

    The poor treatment prognosis for tumors with high levels of hypoxia is usually attributed to the decreased sensitivity of hypoxic cells to ionizing radiation. Mechanistic considerations suggest that linear quadratic (LQ) survival model radiosensitivity parameters for hypoxic (H) and aerobic (A) cells are related by α H =α A /oxygen enhancement ratio (OER) and (α/β) H =OER(α/β) A . The OER parameter may be interpreted as the ratio of the dose to the hypoxic cells to the dose to the aerobic cells required to produce the same number of DSBs per cell. The validity of these expressions is tested against survival data for mammalian cells irradiated in vitro with low- and high-LET radiation. Estimates of hypoxic and aerobic radiosensitivity parameters are derived from independent and simultaneous least-squares fits to the survival data. An external bootstrap procedure is used to test whether independent fits to the survival data give significantly better predictions than simultaneous fits to the aerobic and hypoxic data. For low-LET radiation, estimates of the OER derived from the in vitro data are between 2.3 and 3.3 for extreme levels of hypoxia. The estimated range for the OER is similar to the oxygen enhancement ratios reported in the literature for the initial yield of DSBs. The half-time for sublethal damage repair was found to be independent of oxygen concentration. Analysis of patient survival data for cervix cancer suggests an average OER less than or equal to 1.5, which corresponds to a pO 2 of 5 mm Hg (0.66%) in the in vitro experiments. Because the OER derived from the cervix cancer data is averaged over cells at all oxygen levels, cells irradiated in vivo under extreme levels of hypoxia (<0.5 mm Hg) may have an OER substantially higher than 1.5. The reported analyses of in vitro data, as well as mechanistic considerations, provide strong support for the expressions relating hypoxic and aerobic radiosensitivity parameters. The formulas are also useful

  2. Neutral vs positive oral contrast in diagnosing acute appendicitis with contrast-enhanced CT: sensitivity, specificity, reader confidence and interpretation time

    Science.gov (United States)

    Naeger, D M; Chang, S D; Kolli, P; Shah, V; Huang, W; Thoeni, R F

    2011-01-01

    Objective The study compared the sensitivity, specificity, confidence and interpretation time of readers of differing experience in diagnosing acute appendicitis with contrast-enhanced CT using neutral vs positive oral contrast agents. Methods Contrast-enhanced CT for right lower quadrant or right flank pain was performed in 200 patients with neutral and 200 with positive oral contrast including 199 with proven acute appendicitis and 201 with other diagnoses. Test set disease prevalence was 50%. Two experienced gastrointestinal radiologists, one fellow and two first-year residents blindly assessed all studies for appendicitis (2000 readings) and assigned confidence scores (1=poor to 4=excellent). Receiver operating characteristic (ROC) curves were generated. Total interpretation time was recorded. Each reader's interpretation with the two agents was compared using standard statistical methods. Results Average reader sensitivity was found to be 96% (range 91–99%) with positive and 95% (89–98%) with neutral oral contrast; specificity was 96% (92–98%) and 94% (90–97%). For each reader, no statistically significant difference was found between the two agents (sensitivities p-values >0.6; specificities p-values>0.08), in the area under the ROC curve (range 0.95–0.99) or in average interpretation times. In cases without appendicitis, positive oral contrast demonstrated improved appendix identification (average 90% vs 78%) and higher confidence scores for three readers. Average interpretation times showed no statistically significant differences between the agents. Conclusion Neutral vs positive oral contrast does not affect the accuracy of contrast-enhanced CT for diagnosing acute appendicitis. Although positive oral contrast might help to identify normal appendices, we continue to use neutral oral contrast given its other potential benefits. PMID:20959365

  3. Semiautomatic imputation of activity travel diaries : use of global positioning system traces, prompted recall, and context-sensitive learning algorithms

    NARCIS (Netherlands)

    Moiseeva, A.; Jessurun, J.; Timmermans, H.J.P.

    2010-01-01

    The new generation of dynamic activity-based models requires multiday or multiweek activity-travel data. Global Positioning System (GPS) tracers may be a powerful technology to collect such data, but previous applications of this technology to collect data of full activity travel patterns (not just

  4. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results

    DEFF Research Database (Denmark)

    Pastorello, Elide A; Vieths, Stefan; Pravettoni, Valerio

    2002-01-01

    The hazelnut major allergens identified to date are an 18-kd protein homologous to Bet v 1 and a 14-kd allergen homologous to Bet v 2. No studies have reported hazelnut allergens recognized in patients with positive double-blind, placebo-controlled food challenge (DBPCFC) results or in patients...

  5. Design and construction techniques for one-meter position sensitive proportional counters of the helical delay line type

    International Nuclear Information System (INIS)

    Orbesen, S.D.; Sherman, J.D.; Flynn, E.R.

    1976-03-01

    A description is given of the techniques involved in the construction of a one-meter long helical proportional counter which produces excellent position accuracy of 1 mm while yielding particle identification through a measurement of energy loss and total energy

  6. A position sensitive gamma-ray detector which employs photodiode and CsI (T1) crystals

    International Nuclear Information System (INIS)

    Dean, A.J.; Graham, G.; Hopkins, C.J.; Ramsden, D.; Lei, M.

    1987-01-01

    A compact CsI(Tl)/photodiode gamma-ray detector is described which is capable of locating the point of interaction of incident gamma-ray photons in the spectral region around 1 MeV. Laboratory tests are used to quantify both the spectral and positional resolutions of the detectors. Their likely application in space gamma-ray astronomy is also discussed

  7. Assessment of skin sensitization under REACH: A case report on vehicle choice in the LLNA and its crucial role preventing false positive results.

    Science.gov (United States)

    Watzek, Nico; Berger, Franz; Kolle, Susanne Noreen; Kaufmann, Tanja; Becker, Matthias; van Ravenzwaay, Bennard

    2017-04-01

    In the EU, chemicals with a production or import volume in quantities of one metric ton per year or more have to be tested for skin sensitizing properties under the REACH regulation. The murine Local Lymph Node Assay (LLNA) and its modifications are widely used to fulfil the data requirement, as it is currently considered the first-choice method for in vivo testing to cover this endpoint. This manuscript describes a case study highlighting the importance of understanding the chemistry of the test material during testing for 'skin sensitization' of MCDA (mixture of 2,4- and 2,6-diamino-methylcyclohexane) with particular focus on the vehicle used. While the BrdU-ELISA modification of the LLNA using acetone/olive oil (AOO) as vehicle revealed expectable positive results. However, the concentration control analysis unexpectedly revealed an instability of MCDA in the vehicle AOO. Further studies on the reactivity showed MCDA to rapidly react with AOO under formation of various imine structures, which might have caused the positive LLNA result. The repetition of the LLNA using propylene glycol (PG) as vehicle did not confirm the positive results of the LLNA using AOO. Finally, a classification of MCDA as skin sensitizer according to the Globally Harmonized System (GHS) was not justified. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Simulation of Transient Response of Ir-TES for Position-Sensitive TES with Waveform Domain Multiplexing

    Science.gov (United States)

    Minamikawa, Y.; Sato, H.; Mori, F.; Damayanthi, R. M. T.; Takahashi, H.; Ohno, M.

    2008-04-01

    We are developing a new x-ray microcalorimeter based on a superconducting transition edge sensor (TES) as an imaging sensor. Our measurement shows unique waveforms which we consider as an expression of thermal nonuniformity of TES films. This arises from the different thermal responses, so that response signal shapes would vary according to the position of the incident x-ray. This position dependency deteriorate the measured energy resolution, but with appropriate waveform analysis, this would be useful for imaging device. For more inspection, we have developed a simulation code which enables a dynamic simulation to obtain a transient response of the TES by finite differential method. Temperature and electric current distributions are calculated. As a result, we successfully obtained waveform signals. The calculated signal waveforms have similar characteristics to the measured signals. This simulation visualized the transition state of the device and will help to design better detector.

  9. Simulation study of signal formation in position sensitive planar p-on-n silicon detectors after short range charge injection

    International Nuclear Information System (INIS)

    Peltola, T.; Eremin, V.; Verbitskaya, E.; Härkönen, J.

    2017-01-01

    Segmented silicon detectors (micropixel and microstrip) are the main type of detectors used in the inner trackers of Large Hadron Collider (LHC) experiments at CERN. Due to the high luminosity and eventual high fluence of energetic particles, detectors with fast response to fit the short shaping time of 20–25 ns and sufficient radiation hardness are required. Charge collection measurements carried out at the Ioffe Institute have shown a reversal of the pulse polarity in the detector response to short-range charge injection. Since the measured negative signal is about 30–60% of the peak positive signal, the effect strongly reduces the CCE even in non-irradiated detectors. For further investigation of the phenomenon the measurements have been reproduced by TCAD simulations. As for the measurements, the simulation study was applied for the p-on-n strip detectors similar in geometry to those developed for the ATLAS experiment and for the Ioffe Institute designed p-on-n strip detectors with each strip having a window in the metallization covering the p + implant, allowing the generation of electron-hole pairs under the strip implant. Red laser scans across the strips and the interstrip gap with varying laser diameters and Si-SiO 2 interface charge densities ( Q f ) were carried out. The results verify the experimentally observed negative response along the scan in the interstrip gap. When the laser spot is positioned on the strip p + implant the negative response vanishes and the collected charge at the active strip increases respectively. The simulation results offer a further insight and understanding of the influence of the oxide charge density in the signal formation. The main result of the study is that a threshold value of Q f , that enables negligible losses of collected charges, is defined. The observed effects and details of the detector response for different charge injection positions are discussed in the context of Ramo's theorem.

  10. Simulation study of signal formation in position sensitive planar p-on-n silicon detectors after short range charge injection

    Science.gov (United States)

    Peltola, T.; Eremin, V.; Verbitskaya, E.; Härkönen, J.

    2017-09-01

    Segmented silicon detectors (micropixel and microstrip) are the main type of detectors used in the inner trackers of Large Hadron Collider (LHC) experiments at CERN. Due to the high luminosity and eventual high fluence of energetic particles, detectors with fast response to fit the short shaping time of 20-25 ns and sufficient radiation hardness are required. Charge collection measurements carried out at the Ioffe Institute have shown a reversal of the pulse polarity in the detector response to short-range charge injection. Since the measured negative signal is about 30-60% of the peak positive signal, the effect strongly reduces the CCE even in non-irradiated detectors. For further investigation of the phenomenon the measurements have been reproduced by TCAD simulations. As for the measurements, the simulation study was applied for the p-on-n strip detectors similar in geometry to those developed for the ATLAS experiment and for the Ioffe Institute designed p-on-n strip detectors with each strip having a window in the metallization covering the p+ implant, allowing the generation of electron-hole pairs under the strip implant. Red laser scans across the strips and the interstrip gap with varying laser diameters and Si-SiO2 interface charge densities (Qf) were carried out. The results verify the experimentally observed negative response along the scan in the interstrip gap. When the laser spot is positioned on the strip p+ implant the negative response vanishes and the collected charge at the active strip increases respectively. The simulation results offer a further insight and understanding of the influence of the oxide charge density in the signal formation. The main result of the study is that a threshold value of Qf, that enables negligible losses of collected charges, is defined. The observed effects and details of the detector response for different charge injection positions are discussed in the context of Ramo's theorem.

  11. Enriched Boron-Doped Amorphous Selenium Based Position-Sensitive Solid-State Thermal Neutron Detector for MPACT Applications

    Energy Technology Data Exchange (ETDEWEB)

    Mandal, Krishna [Univ. of South Carolina, Columbia, SC (United States)

    2017-09-29

    High-efficiency thermal neutron detectors with compact size, low power-rating and high spatial, temporal and energy resolution are essential to execute non-proliferation and safeguard protocols. The demands of such detector are not fully covered by the current detection system such as gas proportional counters or scintillator-photomultiplier tube combinations, which are limited by their detection efficiency, stability of response, speed of operation, and physical size. Furthermore, world-wide shortage of 3He gas, required for widely used gas detection method, has further prompted to design an alternative system. Therefore, a solid-state neutron detection system without the requirement of 3He will be very desirable. To address the above technology gap, we had proposed to develop new room temperature solidstate thermal neutron detectors based on enriched boron (10B) and enriched lithium (6Li) doped amorphous Se (As- 0.52%, Cl 5 ppm) semiconductor for MPACT applications. The proposed alloy materials have been identified for its many favorable characteristics - a wide bandgap (~2.2 eV at 300 K) for room temperature operation, high glass transition temperature (tg ~ 85°C), a high thermal neutron cross-section (for boron ~ 3840 barns, for lithium ~ 940 barns, 1 barn = 10-24 cm2), low effective atomic number of Se for small gamma ray sensitivity, and high radiation tolerance due to its amorphous structure.

  12. Enriched Boron-Doped Amorphous Selenium Based Position-Sensitive Solid-State Thermal Neutron Detector for MPACT Applications

    International Nuclear Information System (INIS)

    Mandal, Krishna

    2017-01-01

    High-efficiency thermal neutron detectors with compact size, low power-rating and high spatial, temporal and energy resolution are essential to execute non-proliferation and safeguard protocols. The demands of such detector are not fully covered by the current detection system such as gas proportional counters or scintillator-photomultiplier tube combinations, which are limited by their detection efficiency, stability of response, speed of operation, and physical size. Furthermore, world-wide shortage of 3 He gas, required for widely used gas detection method, has further prompted to design an alternative system. Therefore, a solid-state neutron detection system without the requirement of 3 He will be very desirable. To address the above technology gap, we had proposed to develop new room temperature solidstate thermal neutron detectors based on enriched boron ( 10 B) and enriched lithium ( 6 Li) doped amorphous Se (As- 0.52%, Cl 5 ppm) semiconductor for MPACT applications. The proposed alloy materials have been identified for its many favorable characteristics - a wide bandgap (~2.2 eV at 300 K) for room temperature operation, high glass transition temperature (t g ~ 85°C), a high thermal neutron cross-section (for boron ~ 3840 barns, for lithium ~ 940 barns, 1 barn = 10 -24 cm 2 ), low effective atomic number of Se for small gamma ray sensitivity, and high radiation tolerance due to its amorphous structure.

  13. Low Temperature-Induced 30 (LTI30 positively regulates drought stress resistance in Arabidopsis: effect on abscisic acid sensitivity and hydrogen peroxide accumulation

    Directory of Open Access Journals (Sweden)

    Haitao eShi

    2015-10-01

    Full Text Available As a dehydrin belonging to group II late embryogenesis abundant protein (LEA family, Arabidopsis Low Temperature-Induced 30 (LTI30/XERO2 has been shown to be involved in plant freezing stress resistance. However, the other roles of AtLTI30 remain unknown. In this study, we found that the expression of AtLTI30 was largely induced by drought stress and abscisic acid (ABA treatments. Thereafter, AtLTI30 knockout mutants and overexpressing plants were isolated to investigate the possible involvement of AtLTI30 in ABA and drought stress responses. AtLTI30 knockout mutants were less sensitive to ABA-mediated seed germination, while AtLTI30 overexpressing plants were more sensitive to ABA compared with wild type (WT. Consistently, the AtLTI30 knockout mutants displayed decreased drought stress resistance, while the AtLTI30 overexpressing plants showed improved drought stress resistance compared with WT, as evidenced by a higher survival rate and lower leaf water loss than WT after drought stress. Moreover, manipulation of AtLTI30 expression positively regulated the activities of catalases (CATs and endogenous proline content, as a result, negatively regulated drought stress-triggered hydrogen peroxide (H2O2 accumulation. All these results indicate that AtLTI30 is a positive regulator of plant drought stress resistance, partially through the modulation of ABA sensitivity, H2O2 and proline accumulation.

  14. The application in detection the position accuracy of the multi-leaf collimator of Varian linear accelerator with dynamic therapy log files

    International Nuclear Information System (INIS)

    Li Changhu; Xu Liming; Teng Jianjian; Ge Wei; Zhang Jun; Ma Guangdong

    2010-01-01

    Objective: To explorer the application in detection the position accuracy of the multileaf collimator of Varian accelerator with dynamic therapy log files. Methods: A pre-designed MLC format files named PMLC for two Varian accelerators, the dynamic treatment log files were recorded 10 times on a different date, and be converted into the MLC format files named DMLC, compared with the original plan PMLC, so we can analysis two files for each leaf position deviation. In addition, we analysis the repeatability of MLC leaves position accuracy between 10 dynalog files of two accelerators. Results: No statistically significant difference between the average position of the 10 times leaf position of the two accelerators,their were 0.29 -0.29 and 0.29 -0.30 (z = -0.77, P=0.442). About 40%, 30%, 20% and 10% of the leaf position deviation was at ≤0.2 mm, 0.3 mm, 0.5 mm and 0.4 mm, respectively. the maximum value was 0.5 mm. More than 86% of the leaf position are completely coincident between 10 dynamic treatment files of two accelerators. The rate of position deviation no more 0. 05 mm was 96. 6% and 97.3%, respectively. And the maximum value was 0.09 mm. Conclusions: Dynamic treatment log file is a splendid tool in testing the actual position of multi-leaf collimator. The multi-leaf collimator of two accelerators be detected are precise and stabilized. (authors)

  15. Hole-Initiated-Avalanche, Linear-Mode, Single-Photon-Sensitive Avalanche Photodetector with Reduced Excess Noise and Low Dark Count Rate, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A radiation hard, single photon sensitive InGaAs avalanche photodiode (APD) receiver technology will be demonstrated useful for long range space based optical...

  16. Linear algebra

    CERN Document Server

    Shilov, Georgi E

    1977-01-01

    Covers determinants, linear spaces, systems of linear equations, linear functions of a vector argument, coordinate transformations, the canonical form of the matrix of a linear operator, bilinear and quadratic forms, Euclidean spaces, unitary spaces, quadratic forms in Euclidean and unitary spaces, finite-dimensional space. Problems with hints and answers.

  17. Positive association between high-sensitivity C-reactive protein level and diabetes mellitus among US non-Hispanic black adults.

    Science.gov (United States)

    Shankar, A; Li, J

    2008-08-01

    Previous epidemiologic studies have demonstrated a positive association between serum C-reactive protein (CRP) level and diabetes mellitus. However among US race-ethnicities, the putative association between CRP and diabetes mellitus in non-Hispanic Blacks is not clear. We specifically examined the association between high-sensitivity CRP level and diabetes mellitus in a representative sample of US non-Hispanic blacks. Cross-sectional study among 1,479 National Health and Nutrition Examination Survey 1999-2002 non-Hispanic black participants aged > or = 20 years. Main outcome-of-interest was the presence of diabetes mellitus (fasting plasma glucose > or = 126 mg/dL, non-fasting plasma glucose > or = 200 mg/dL, or self-reported current use of oral hypoglycemic medication or insulin) (n=204). Higher CRP levels were positively associated with diabetes mellitus, independent of smoking, waist circumference, hypertension, and other confounders. Multivariable odds ratio (OR) [95% confidence intervals (CI)] comparing elevated CRP level (>3 mg/L) to low CRP level (diabetes mellitus appeared to be present across the full range of CRP, without any threshold effect. Higher serum high-sensitivity CRP levels are positively associated with diabetes mellitus in a sample of US non-Hispanic blacks. Inflammatory processes previously shown to be related to diabetes mellitus in other race-ethnicities may be involved in non-Hispanic blacks also.

  18. School, Supervision and Adolescent-Sensitive Clinic Care: Combination Social Protection and Reduced Unprotected Sex Among HIV-Positive Adolescents in South Africa.

    Science.gov (United States)

    Toska, Elona; Cluver, Lucie D; Boyes, Mark E; Isaacsohn, Maya; Hodes, Rebecca; Sherr, Lorraine

    2017-09-01

    Social protection can reduce HIV-risk behavior in general adolescent populations, but evidence among HIV-positive adolescents is limited. This study quantitatively tests whether social protection is associated with reduced unprotected sex among 1060 ART-eligible adolescents from 53 government facilities in South Africa. Potential social protection included nine 'cash/cash-in-kind' and 'care' provisions. Analyses tested interactive/additive effects using logistic regressions and marginal effects models, controlling for covariates. 18 % of all HIV-positive adolescents and 28 % of girls reported unprotected sex. Lower rates of unprotected sex were associated with access to school (OR 0.52 95 % CI 0.33-0.82 p = 0.005), parental supervision (OR 0.54 95 % CI 0.33-0.90 p = 0.019), and adolescent-sensitive clinic care (OR 0.43 95 % CI 0.25-0.73 p = 0.002). Gender moderated the effect of adolescent-sensitive clinic care. Combination social protection had additive effects amongst girls: without any provisions 49 % reported unprotected sex; with 1-2 provisions 13-38 %; and with all provisions 9 %. Combination social protection has the potential to promote safer sex among HIV-positive adolescents, particularly girls.

  19. Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Juntao; Mao, Zhangfan; Huang, Jie; Xie, Songping; Liu, Tianshu; Mao, Zhifu, E-mail: 48151660@qq.com

    2014-02-21

    Highlights: • Notch signaling pathway members are expressed lower levels in CD133+ cells. • CD133+ cells are not as sensitive as CD133− cells to chemotherapy. • GSI could inhibit the growth of both CD133+ and CD133− cells. • Blockade of Notch signaling pathway enhanced the effect of chemotherapy with CDDP. • DAPT/CDDP co-therapy caused G2/M arrest and elimination in CD133+ cells. - Abstract: Cancer stem cells (CSCs) are believed to play an important role in tumor growth and recurrence. These cells exhibit self-renewal and proliferation properties. CSCs also exhibit significant drug resistance compared with normal tumor cells. Finding new treatments that target CSCs could significantly enhance the effect of chemotherapy and improve patient survival. Notch signaling is known to regulate the development of the lungs by controlling the cell-fate determination of normal stem cells. In this study, we isolated CSCs from the human lung adenocarcinoma cell line A549. CD133 was used as a stem cell marker for fluorescence-activated cell sorting (FACS). We compared the expression of Notch signaling in both CD133+ and CD133− cells and blocked Notch signaling using the γ-secretase inhibitor DAPT (GSI-IX). The effect of combining GSI and cisplatin (CDDP) was also examined in these two types of cells. We observed that both CD133+ and CD133− cells proliferated at similar rates, but the cells exhibited distinctive differences in cell cycle progression. Few CD133+ cells were observed in the G{sub 2}/M phase, and there were half as many cells in S phase compared with the CD133− cells. Furthermore, CD133+ cells exhibited significant resistance to chemotherapy when treated with CDDP. The expression of Notch signaling pathway members, such as Notch1, Notch2 and Hes1, was lower in CD133+ cells. GSI slightly inhibited the proliferation of both cell types and exhibited little effect on the cell cycle. The inhibitory effects of DPP on these two types of cells were

  20. Computed tomography with thermal neutrons and gaseous position sensitive detector; Tomografia computadorizada com neutrons termicos e detetor a gas sensivel a posicao

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Maria Ines Silvani

    2001-12-01

    A third generation tomographic system using a parallel thermal neutron beam and gaseous position sensitive detector has been developed along three discrete phases. At the first one, X-ray tomographic images of several objects, using a position sensitive detector designed and constructed for this purpose have been obtained. The second phase involved the conversion of that detector for thermal neutron detection, by using materials capable to convert neutrons into detectable charged particles, testing afterwards its performance in a tomographic system by evaluation the quality of the image arising from several test-objects containing materials applicable in the engineering field. High enriched {sup 3} He, replacing the argon-methane otherwise used as filling gas for the X-ray detection, as well as, a gadolinium foil, have been utilized as converters. Besides the pure enriched {sup 3} He, its mixture with argon-methane and later on with propane, have been also tested, in order to evaluate the detector efficiency and resolution. After each gas change, the overall performance of the tomographic system using the modified detector, has been analyzed through measurements of the related parameters. This was done by analyzing the images produced by test-objects containing several materials having well known attenuation coefficients for both thermal neutrons and X-rays. In order to compare the performance of the position sensitive detector as modified to detect thermal neutrons, with that of a conventional BF{sub 3} detector, additional tomographs have been conducted using the last one. The results have been compared in terms of advantages, handicaps and complementary aspects for different kinds of radiation and materials. (author)

  1. Data mining methods in the prediction of Dementia: A real-data comparison of the accuracy, sensitivity and specificity of linear discriminant analysis, logistic regression, neural networks, support vector machines, classification trees and random forests

    Directory of Open Access Journals (Sweden)

    Santana Isabel

    2011-08-01

    Full Text Available Abstract Background Dementia and cognitive impairment associated with aging are a major medical and social concern. Neuropsychological testing is a key element in the diagnostic procedures of Mild Cognitive Impairment (MCI, but has presently a limited value in the prediction of progression to dementia. We advance the hypothesis that newer statistical classification methods derived from data mining and machine learning methods like Neural Networks, Support Vector Machines and Random Forests can improve accuracy, sensitivity and specificity of predictions obtained from neuropsychological testing. Seven non parametric classifiers derived from data mining methods (Multilayer Perceptrons Neural Networks, Radial Basis Function Neural Networks, Support Vector Machines, CART, CHAID and QUEST Classification Trees and Random Forests were compared to three traditional classifiers (Linear Discriminant Analysis, Quadratic Discriminant Analysis and Logistic Regression in terms of overall classification accuracy, specificity, sensitivity, Area under the ROC curve and Press'Q. Model predictors were 10 neuropsychological tests currently used in the diagnosis of dementia. Statistical distributions of classification parameters obtained from a 5-fold cross-validation were compared using the Friedman's nonparametric test. Results Press' Q test showed that all classifiers performed better than chance alone (p Conclusions When taking into account sensitivity, specificity and overall classification accuracy Random Forests and Linear Discriminant analysis rank first among all the classifiers tested in prediction of dementia using several neuropsychological tests. These methods may be used to improve accuracy, sensitivity and specificity of Dementia predictions from neuropsychological testing.

  2. On the use of one-dimensional position sensitive detector for x-ray diffraction reciprocal space mapping: Data quality and limitations

    International Nuclear Information System (INIS)

    Masson, Olivier; Boulle, Alexandre; Guinebretiere, Rene; Lecomte, Andre; Dauger, Alain

    2005-01-01

    A homemade x-ray diffractometer using one-dimensional position sensitive detector (PSD) and well suited to the study of thin epitaxial layer systems is presented. It is shown how PSDs can be advantageously used to allow fast reciprocal space mapping, which is especially interesting when analyzing poor crystalline and defective layers as usually observed with oxides and ceramics films. The quality of the data collected with such a setup and the limitations of PSDs in comparison with the use of analyzer crystals are discussed. In particular, the effects of PSD on angular precision, instrument resolution and corrections that must be applied to raw data are presented

  3. The use of a position sensitive detector or of a multidetector for the measurement of pole figures by neutron time-of-flight technique

    International Nuclear Information System (INIS)

    Walther, K.

    1990-01-01

    The neutron flux of even high flux reactors is weak in comparison with the quantum flux of X-ray tubes and therefore in order to decrease the expense on measuring time more and more neutron diffractometers are equipped with position sensitive detectors or multidetectors. In this paper the peculiarities of the use of such detecting devices are discussed for the measurement of pole figures. A special arrangement of a multidetector is proposed which will allow one to scan the whole pole figure by rotating the sample about only one axis and considerably will save measuring time. 4 refs.; 5 figs

  4. Study on TVD parameters sensitivity of a crankshaft using multiple scale and state space method considering quadratic and cubic non-linearities

    Directory of Open Access Journals (Sweden)

    R. Talebitooti

    Full Text Available In this paper the effect of quadratic and cubic non-linearities of the system consisting of the crankshaft and torsional vibration damper (TVD is taken into account. TVD consists of non-linear elastomer material used for controlling the torsional vibration of crankshaft. The method of multiple scales is used to solve the governing equations of the system. Meanwhile, the frequency response of the system for both harmonic and sub-harmonic resonances is extracted. In addition, the effects of detuning parameters and other dimensionless parameters for a case of harmonic resonance are investigated. Moreover, the external forces including both inertia and gas forces are simultaneously applied into the model. Finally, in order to study the effectiveness of the parameters, the dimensionless governing equations of the system are solved, considering the state space method. Then, the effects of the torsional damper as well as all corresponding parameters of the system are discussed.

  5. Production of positive pions from polarized protons by linearly polarized photons in the energy region 300--420 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Get' man, V.A.; Gorbenko, V.G.; Grushin, V.F.; Derkach, A.Y.; Zhebrovskii, Y.V.; Karnaukhov, I.M.; Kolesnikov, L.Y.; Luchanin, A.A.; Rubashkin, A.L.; Sanin, V.M.; Sorokin, P.V.; Sporov, E.A.; Telegin, Y.N.; Shalatskii, S.V.

    1980-10-01

    A technique for measurement of the polarization observables ..sigma.., P, and T for the reaction ..gamma..p..-->..n..pi../sup +/ in a doubly polarized experiment (polarized proton target + linearly polarized photon beam) is described. Measurements of the angular distributions of these observables in the range of pion emission angles 30--150/sup 0/ are presented for four photon energies from 300 to 420 MeV. Inclusion of the new experimental data in an energy-independent multipole analysis of photoproduction from protons permits a more reliable selection of solutions to be made.

  6. Sensitivity, specificity and predictive probability values of serum agglutination test titres for the diagnosis of Salmonella Dublin culture-positive bovine abortion and stillbirth.

    Science.gov (United States)

    Sánchez-Miguel, C; Crilly, J; Grant, J; Mee, J F

    2018-06-01

    The objective of this study was to determine the diagnostic value of maternal serology for the diagnosis of Salmonella Dublin bovine abortion and stillbirth. A retrospective, unmatched, case-control study was carried out using twenty year's data (1989-2009) from bovine foetal submissions to an Irish government veterinary laboratory. Cases (n = 214) were defined as submissions with a S. Dublin culture-positive foetus from a S. Dublin unvaccinated dam where results of maternal S. Dublin serology were available. Controls (n = 415) were defined as submissions where an alternative diagnosis other than S. Dublin was made in a foetus from an S. Dublin unvaccinated dam where the results of maternal S. Dublin serology were available. A logistic regression model was fitted to the data: the dichotomous dependent variable was the S. Dublin foetal culture result, and the independent variables were the maternal serum agglutination test (SAT) titre results. Salmonella serology correctly classified 87% of S. Dublin culture-positive foetuses at a predicted probability threshold of 0.44 (cut-off at which sensitivity and specificity are at a maximum, J = 0.67). The sensitivity of the SAT at the same threshold was 73.8% (95% CI: 67.4%-79.5%), and the specificity was 93.2% (95% CI: 90.3%-95.4%). The positive and negative predictive values were 84.9% (95% CI: 79.3%-88.6%) and 87.3% (95% CI: 83.5%-91.3%), respectively. This study illustrates that the use of predicted probability values, rather than the traditional arbitrary breakpoints of negative, inconclusive and positive, increases the diagnostic value of the maternal SAT. Veterinary laboratory diagnosticians and veterinary practitioners can recover from the test results, information previously categorized, particularly from those results declared to be inconclusive. © 2017 Blackwell Verlag GmbH.

  7. Effects of blood-feeding on olfactory sensitivity of the malaria mosquito Anopheles gambiae: application of mixed linear models to account for repeated measurements

    NARCIS (Netherlands)

    Qiu, Y.T.; Gort, G.; Torricelli, A.; Takken, W.; Loon, van J.J.A.

    2013-01-01

    Olfaction plays an important role in the host-seeking behavior of the malaria mosquito Anopheles gambiae. After a complete blood meal, female mosquitoes will not engage in host-seeking behavior until oviposition has occurred. We investigated if peripheral olfactory sensitivity changed after a blood

  8. Simultaneous resolution of spectral and temporal properties of UV and visible fluorescence using single-photon counting with a position-sensitive detector

    International Nuclear Information System (INIS)

    Kelly, L.A.; Trunk, J.G.; Polewski, K.; Sutherland, J.C.

    1995-01-01

    A new fluorescence spectrometer has been assembled at the U9B beamline of the National Synchrotron Light Source to allow simultaneous multiwavelength and time-resolved fluorescence detection, as well as spatial imaging of the sample fluorescence. The spectrometer employs monochromatized, tunable UV and visible excitation light from a synchrotron bending magnet and an imaging spectrograph equipped with a single-photon sensitive emission detector. The detector is comprised of microchannel plates in series, with a resistive anode for encoding the position of the photon-derived current. The centroid position of the photon-induced electron cascade is derived in a position analyzer from the four signals measured at the corners of the resistive anode. Spectral information is obtained by dispersing the fluorescence spectrum across one dimension of the detector photocathode. Timing information is obtained by monitoring the voltage divider circuit at the last MCP detector. The signal from the MCP is used as a ''start'' signal to perform a time-correlated single photon counting experiment. The analog signal representing the position, and hence wavelength, is digitized concomitantly with the start/stop time difference and stored in the two-dimensional histogramming memory of a multiparameter analyzer

  9. In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species.

    Science.gov (United States)

    Farrell, David J; Robbins, Marion; Rhys-Williams, William; Love, William G

    2010-06-01

    The antibacterial activity of XF-73, a dicationic porphyrin drug, was investigated against a range of Gram-positive and Gram-negative bacteria with known antibiotic resistance profiles, including resistance to cell wall synthesis, protein synthesis, and DNA and RNA synthesis inhibitors as well as cell membrane-active antibiotics. Antibiotic-sensitive strains for each of the bacterial species tested were also included for comparison purposes. XF-73 was active [minimum inhibitory concentration (MIC) 0.25-4 mg/L] against all of the Gram-positive bacteria tested, irrespective of the antibiotic resistance profile of the isolates, suggesting that the mechanism of action of XF-73 is unique compared with the major antibiotic classes. Gram-negative activity was lower (MIC 1 mg/L to > 64 mg/L). Minimum bactericidal concentration data confirmed that the activity of XF-73 was bactericidal. Time-kill kinetics against healthcare-associated and community-associated meticillin-resistant Staphylococcus aureus isolates demonstrated that XF-73 was rapidly bactericidal, with > 5 log(10) kill obtained after 15 min at 2 x MIC, the earliest time point sampled. The post-antibiotic effect (PAE) for XF-73 under conditions where the PAE for vancomycin was 5.4 h. XF-73 represents a novel broad-spectrum Gram-positive antibacterial drug with potentially beneficial characteristics for the treatment and prevention of Gram-positive bacterial infections. 2010. Published by Elsevier B.V.

  10. Comparison of multi-pole shaping and delay line clipping pre-amplifiers for position sensitive NaI(Tl) detectors

    International Nuclear Information System (INIS)

    Freifelder, R.; Karp, J.S.; Wear, J.A.; Lockyer, N.S.; Newcomer, F.M.; Surti, S.; Berg, R. van

    1998-01-01

    NaI(Tl) position sensitive detectors have been used in medical imaging for many years. For PET applications without collimators, the high counting rates place severe demands on such large area detectors. The NaI(Tl) detectors in the PENN-PET scanners are read-out via photomultiplier tubes and preamplifiers. Those preamplifiers use a delay-line clipping technique to shorten the characteristic 240 ns fall time of the NaI(Tl) signal. As an alternative, the authors have investigated a pole-zero network to shorten the signal followed by a multi-pole shaper to produce a symmetric signal suitable for high counting rates. This has been compared to the current design by measuring the energy and spatial resolution of a single detector as a function of different preamplifier designs. Data were taken over a range of ADC integration times and countrates. The new design shows improved energy resolution with short integration times. Effects on spatial resolution and deadtime are reported for large position sensitive detectors at different countrates

  11. Evolutionary Analysis Predicts Sensitive Positions of MMP20 and Validates Newly- and Previously-Identified MMP20 Mutations Causing Amelogenesis Imperfecta.

    Science.gov (United States)

    Gasse, Barbara; Prasad, Megana; Delgado, Sidney; Huckert, Mathilde; Kawczynski, Marzena; Garret-Bernardin, Annelyse; Lopez-Cazaux, Serena; Bailleul-Forestier, Isabelle; Manière, Marie-Cécile; Stoetzel, Corinne; Bloch-Zupan, Agnès; Sire, Jean-Yves

    2017-01-01

    Amelogenesis imperfecta (AI) designates a group of genetic diseases characterized by a large range of enamel disorders causing important social and health problems. These defects can result from mutations in enamel matrix proteins or protease encoding genes. A range of mutations in the enamel cleavage enzyme matrix metalloproteinase-20 gene ( MMP20 ) produce enamel defects of varying severity. To address how various alterations produce a range of AI phenotypes, we performed a targeted analysis to find MMP20 mutations in French patients diagnosed with non-syndromic AI. Genomic DNA was isolated from saliva and MMP20 exons and exon-intron boundaries sequenced. We identified several homozygous or heterozygous mutations, putatively involved in the AI phenotypes. To validate missense mutations and predict sensitive positions in the MMP20 sequence, we evolutionarily compared 75 sequences extracted from the public databases using the Datamonkey webserver. These sequences were representative of mammalian lineages, covering more than 150 million years of evolution. This analysis allowed us to find 324 sensitive positions (out of the 483 MMP20 residues), pinpoint functionally important domains, and build an evolutionary chart of important conserved MMP20 regions. This is an efficient tool to identify new- and previously-identified mutations. We thus identified six functional MMP20 mutations in unrelated families, finding two novel mutated sites. The genotypes and phenotypes of these six mutations are described and compared. To date, 13 MMP20 mutations causing AI have been reported, making these genotypes and associated hypomature enamel phenotypes the most frequent in AI.

  12. MHSP with position detection capability

    Energy Technology Data Exchange (ETDEWEB)

    Natal da Luz, H. [Physics Dept., University of Aveiro, 3810-193 Aveiro (Portugal); Physics Dept., University of Coimbra, 3004-516 Coimbra (Portugal); Veloso, J.F.C.A. [Physics Dept., University of Aveiro, 3810-193 Aveiro (Portugal) and Physics Dept., University of Coimbra, 3004-516 Coimbra (Portugal)]. E-mail: jveloso@fis.ua.pt; Mendes, N.F.C. [Physics Dept., University of Coimbra, 3004-516 Coimbra (Portugal); Santos, J.M.F. dos [Physics Dept., University of Coimbra, 3004-516 Coimbra (Portugal); Mir, J.A. [CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11 0QX (United Kingdom)

    2007-04-01

    The first implementation of a position sensitive readout for a Micro Hole and Strip Plate (MHSP) is described and tested. The readout consists on a resistive layer crossing the anodes and connected to a preamplifier on each side. By weighing the charge pulses on both preamplifiers it is possible to determine the interaction point. A 100-200 {omega} resistance layer between consecutive strips was found to be the best compromise between position linearity and energy resolution. Preliminary results using 22.1 keV X-rays present a good linearity between the measured and the actual position with a mean deviation of about 0.15 mm and a position resolution of 1.6 mm full-width at half-maximum (FWHM), being limited by the analogue division electronic circuit. The performance of the MHSP position detector will be presented and discussed for 1D readout.

  13. Characterization of a new dosimeter for the development of a position-sensitive detector of radioactive sources in industrial NDT equipment

    Science.gov (United States)

    Kim, K. T.; Kim, J. H.; Han, M. J.; Heo, Y. J.; Park, S. K.

    2018-02-01

    Imaging technology based on gamma-ray sources has been extensively used in non-destructive testing (NDT) to detect any possible internal defects in products without changing their shapes or functions. However, such technology has been subject to increasingly stricter regulations, and an international radiation-safety management system has been recently established. Consequently, radiation source location in NDT systems has become an essential process, given that it can prevent radiation accidents. In this study, we focused on developing a monitoring system that can detect, in real time, the position of a radioactive source in the source guide tube of a projector. We fabricated a lead iodide (PbI2) dosimeter based on the particle-in-binder method, which has a high production yield and facilitates thickness and shape adjustment. Using a gamma-ray source, we then tested the reproducibility, linearity of the dosimeter response, and the dosimeter's percentage interval distance (PID). It was found that the fabricated PbI2 dosimeter yields highly accurate, reproducible, and linear dose measurements. The PID analysis—conducted to investigate the possibility of developing a monitoring system based on the proposed dosimeter—indicated that the valid detection distance was approximately 11.3 cm. The results of this study are expected to contribute to the development of an easily usable radiation monitoring system capable of significantly reducing the risk of radiation accidents.

  14. Effect of removing the common mode errors on linear regression analysis of noise amplitudes in position time series of a regional GPS network & a case study of GPS stations in Southern California

    Science.gov (United States)

    Jiang, Weiping; Ma, Jun; Li, Zhao; Zhou, Xiaohui; Zhou, Boye

    2018-05-01

    The analysis of the correlations between the noise in different components of GPS stations has positive significance to those trying to obtain more accurate uncertainty of velocity with respect to station motion. Previous research into noise in GPS position time series focused mainly on single component evaluation, which affects the acquisition of precise station positions, the velocity field, and its uncertainty. In this study, before and after removing the common-mode error (CME), we performed one-dimensional linear regression analysis of the noise amplitude vectors in different components of 126 GPS stations with a combination of white noise, flicker noise, and random walking noise in Southern California. The results show that, on the one hand, there are above-moderate degrees of correlation between the white noise amplitude vectors in all components of the stations before and after removal of the CME, while the correlations between flicker noise amplitude vectors in horizontal and vertical components are enhanced from un-correlated to moderately correlated by removing the CME. On the other hand, the significance tests show that, all of the obtained linear regression equations, which represent a unique function of the noise amplitude in any two components, are of practical value after removing the CME. According to the noise amplitude estimates in two components and the linear regression equations, more accurate noise amplitudes can be acquired in the two components.

  15. Rapid and sensitive determination of major polyphenolic components in Euphoria longana Lam. seeds using matrix solid-phase dispersion extraction and UHPLC with hybrid linear ion trap triple quadrupole mass spectrometry.

    Science.gov (United States)

    Rathore, Atul S; Sathiyanarayanan, L; Deshpande, Shreekant; Mahadik, Kakasaheb R

    2016-11-01

    A rapid and sensitive method for the extraction and determination of four major polyphenolic components in Euphoria longana Lam. seeds is presented for the first time based on matrix solid-phase dispersion extraction followed by ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. Matrix solid-phase dispersion method was designed for the extraction of Euphoria longana seed constituents and compared with microwave-assisted extraction and ultrasonic-assisted extraction methods. An Ultra high performance liquid chromatography with hybrid triple quadrupole linear ion-trap mass spectrometry method was developed for quantitative analysis in multiple-reaction monitoring mode in negative electrospray ionization. The chromatographic separation was accomplished using an ACQUITY UPLC BEH C 18 (2.1 mm × 50 mm, 1.7 μm) column with gradient elution of 0.1% aqueous formic acid and 0.1% formic acid in acetonitrile. The developed method was validated with acceptable linearity (r 2 > 0.999), precision (RSD ≤ 2.22%) and recovery (RSD ≤ 2.35%). The results indicated that matrix solid-phase dispersion produced comparable extraction efficiency compared with other methods nevertheless was more convenient and time-saving with reduced requirements on sample and solvent volumes. The proposed method is rapid and sensitive in providing a promising alternative for extraction and comprehensive determination of active components for quality control of Euphoria longana products. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Competitive inhibition can linearize dose-response and generate a linear rectifier.

    Science.gov (United States)

    Savir, Yonatan; Tu, Benjamin P; Springer, Michael

    2015-09-23

    Many biological responses require a dynamic range that is larger than standard bi-molecular interactions allow, yet the also ability to remain off at low input. Here we mathematically show that an enzyme reaction system involving a combination of competitive inhibition, conservation of the total level of substrate and inhibitor, and positive feedback can behave like a linear rectifier-that is, a network motif with an input-output relationship that is linearly sensitive to substrate above a threshold but unresponsive below the threshold. We propose that the evolutionarily conserved yeast SAGA histone acetylation complex may possess the proper physiological response characteristics and molecular interactions needed to perform as a linear rectifier, and we suggest potential experiments to test this hypothesis. One implication of this work is that linear responses and linear rectifiers might be easier to evolve or synthetically construct than is currently appreciated.

  17. Hybrid integrated sensor for position measurement

    International Nuclear Information System (INIS)

    Schmidt, B.; Schott, H.; Just, H.-J.

    1986-01-01

    The design, fabrication and performance of an integrated two-dimensional position sensitive photodetector are presented. The optoelectronic device used as sensitive element in the circuit is a full area position sensitive photodiode (PPD) with high linearity over the full sensitive area. The PPD is integrated with the analog electronics in a hybrid circuit using thick film technology. The analog electronics includes the signal amplification and the signal conditioning to form the output signals proportional to the light beam center position at the sensor surface and an output signal proportional to the light beam intensity. Using hybrid integration a new position sensitive transducer is developed giving output signals, transmiting in large distances without problems and driving directly actuators in any control system

  18. A combined stretching-tilting mechanism produces negative, zero and positive linear thermal expansion in a semi-flexible Cd(II)-MOF.

    Science.gov (United States)

    Lama, Prem; Das, Raj Kumar; Smith, Vincent J; Barbour, Leonard J

    2014-06-21

    A novel semi-flexible Cd(II)-MOF has been synthesized and characterized by variable temperature powder and single-crystal X-ray diffraction. The material displays an unusual combination of thermal expansion (TE) i.e. negative, zero and positive, which is an extremely rare finding, especially for metal-organic frameworks as a result of a combined stretching-tilting mechanism.

  19. Measurable position-sensitive wide-angle interference effects of single photons radiated by a nitrogen-vacancy center in diamond

    International Nuclear Information System (INIS)

    Sandor Varro

    2014-01-01

    Single-photon wide-angle interference phenomena have been studied theoretically for glass-diamond-oil (air) layered structures. As a single optical radiator, one NV-center has been assumed close to the upper surface of a diamond plate, and it was represented by a Hertzian dipole of arbitrary orientation. It has been shown that the far-field interference pattern (of 3/5 or 100% visibility) is sensitive to the vertical position of the NV-center, to that extent that ∼2 nm difference in distance from the upper surface of the diamond results in ∼0.01 degree shift of the pattern, which should be a measurable effect. (author)

  20. Source Apportionment of PM2.5 Mass and Optical Attenuation Over an Ecologically Sensitive Zone in Central India by Positive Matrix Factorization

    Science.gov (United States)

    Nirmalkar, J.; Raman, R. S.

    2016-12-01

    Ambient PM2.5 samples (N=366) were collected over an ecologically sensitive zone (Van Vihar National Park) in Bhopal, Central India for two years (01 January, 2012 to 31 December, 2013). Samples were collected using three co-located Mini-Vol® samplers on Teflon, Nylon, and Quartz filter substrates. The aerosol was then chemically characterized for water-soluble inorganic ions, elements, and carbon fractions (elemental carbon and organic carbon) using ion chromatography, ED-XRF, and thermal-optical EC/OC analyzer, respectively. The optical attenuation (at 370 nm and 800 nm) of PM2.5 aerosols was also determined by optical transmissometry (OT-21). The application of Positive matrix factorization (PMF) to a combination of PM2.5 mass, its ions, elements, carbon fractions, and optical attenuation and its outcomes will be discussed.

  1. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee; Costa, Pedro; Borgnat, Pierre

    2015-01-01

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ CEP varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  2. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    Energy Technology Data Exchange (ETDEWEB)

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee [Universite Claude Bernard de Lyon, Institut de Physique Nucleaire de Lyon, CNRS/IN2P3, Villeurbanne Cedex (France); Costa, Pedro [Universidade de Coimbra, Centro de Fisica Computacional, Departamento de Fisica, Coimbra (Portugal); Borgnat, Pierre [CNRS, l' Ecole normale superieure de Lyon, Laboratoire de Physique, Lyon Cedex 07 (France)

    2015-09-15

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ {sub CEP} varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  3. Fault tolerant linear actuator

    Science.gov (United States)

    Tesar, Delbert

    2004-09-14

    In varying embodiments, the fault tolerant linear actuator of the present invention is a new and improved linear actuator with fault tolerance and positional control that may incorporate velocity summing, force summing, or a combination of the two. In one embodiment, the invention offers a velocity summing arrangement with a differential gear between two prime movers driving a cage, which then drives a linear spindle screw transmission. Other embodiments feature two prime movers driving separate linear spindle screw transmissions, one internal and one external, in a totally concentric and compact integrated module.

  4. Hyperfunctioning parathyroid tumours in patients with thyroid nodules. Sensitivity and positive predictive value of high-resolution ultrasonography and 99mTc-sestamibi scintigraphy.

    Science.gov (United States)

    Lumachi, F; Marzola, M C; Zucchetta, P; Tregnaghi, A; Cecchin, D; Bui, F

    2003-09-01

    A series of 112 consecutive patients with primary hyperparathyroidism who underwent both high-resolution neck ultrasonography (US) and 99mTc-sestamibi/99mTc-pertechnetate subtraction scintigraphy (SS) prior to successful parathyroidectomy was reviewed. There were 29 (25.9%) men and 83 (74.1%) women, with a median age of 58 years (range 13-78 years). Patients were divided into two groups, according to the preoperative US findings: group A (87 patients, 77.7%) without thyroid diseases, and group B (25 patients, 22.3%) with either multinodular goitre or a solitary nontoxic thyroid nodule. In group B patients partial or total thyroidectomy was also performed, according to the intraoperative findings and frozen-section examination results. Final histopathology showed 99 (88.4%) solitary parathyroid (PT) adenomas and 3 (2.7%) PT carcinomas, while 10 (8.9%) patients had a multiglandular disease. The sensitivity and positive predictive value (PPV) were (group A vs group B) 79.8% vs 70.8% (P=0.25) and 95.7% vs 94.4% (P=0.58) for US, and 83.3% vs 87.0% (P=0.47) and 95.9% vs 90.9% (P=0.32) for SS respectively. Better but similar (P=not significant) results were obtained in patients with solitary PT tumours: 81.5% vs 77.8% (US) and 85.0 vs 94.1% (SS) sensitivity; 97.1% vs 93.3% (US) and 95.8% vs 88.9% (SS) PPV. Overall, the combination of US and SS was 92.9% sensitive (group A=93.1%, group B=92.0%; P=0.55), and the PPV reached 100% in each group. In conclusion, in patients with primary hyperparathyroidism the results of both US and SS are independent of coexistent thyroid disease, especially in patients with solitary PT tumours.

  5. Evolutionary Analysis Predicts Sensitive Positions of MMP20 and Validates Newly- and Previously-Identified MMP20 Mutations Causing Amelogenesis Imperfecta

    Directory of Open Access Journals (Sweden)

    Barbara Gasse

    2017-06-01

    Full Text Available Amelogenesis imperfecta (AI designates a group of genetic diseases characterized by a large range of enamel disorders causing important social and health problems. These defects can result from mutations in enamel matrix proteins or protease encoding genes. A range of mutations in the enamel cleavage enzyme matrix metalloproteinase-20 gene (MMP20 produce enamel defects of varying severity. To address how various alterations produce a range of AI phenotypes, we performed a targeted analysis to find MMP20 mutations in French patients diagnosed with non-syndromic AI. Genomic DNA was isolated from saliva and MMP20 exons and exon-intron boundaries sequenced. We identified several homozygous or heterozygous mutations, putatively involved in the AI phenotypes. To validate missense mutations and predict sensitive positions in the MMP20 sequence, we evolutionarily compared 75 sequences extracted from the public databases using the Datamonkey webserver. These sequences were representative of mammalian lineages, covering more than 150 million years of evolution. This analysis allowed us to find 324 sensitive positions (out of the 483 MMP20 residues, pinpoint functionally important domains, and build an evolutionary chart of important conserved MMP20 regions. This is an efficient tool to identify new- and previously-identified mutations. We thus identified six functional MMP20 mutations in unrelated families, finding two novel mutated sites. The genotypes and phenotypes of these six mutations are described and compared. To date, 13 MMP20 mutations causing AI have been reported, making these genotypes and associated hypomature enamel phenotypes the most frequent in AI.

  6. Development of 2-d position-sensitive neutron detector with individual readout. Operation test and establishment of detection system by means of neutron beam

    International Nuclear Information System (INIS)

    Tanaka, Hiroki; Yamagishi, Hideshi; Nakamura, Tatsuya; Soyama, Kazuhiko; Aizawa, Kazuya

    2005-04-01

    We have been developing the 2-d position-sensitive neutron detector with individual readout as next-generation-type detector system for neutron scattering experiments using intense pulsed neutron source. The detection system is designed to fulfill the specifications required for each neutron spectrometer, such as a count rate, efficiency, neutron/gamma-ray ratio, a spatial resolution and a size, by using suitable detector heads. The fundamental and imaging performances of the developed system assembled with a Multi-wire proportional counter head were evaluated using a collimated neutron beam. The system worked stably for long hours at the 4 He gas pressure of 5 atm with a mixture of 30% C 2 H 6 (0.26 atom 3 He) at gas gain of 450. The spatial resolutions were 1.4, 1.6 mm (FWHM) for a cathode- and a back strip- direction, respectively, considering a beam size. It was also confirmed that the spatial uniformity of the detection efficiency over the whole sensitive detection area was rather good, ±8% deviation from the average with the optimum discrimination level. (author)

  7. Therapy-refractory Panton Valentine Leukocidin-positive community-acquired methicillin-sensitive Staphylococcus aureus sepsis with progressive metastatic soft tissue infection: a case report

    Directory of Open Access Journals (Sweden)

    Schefold Joerg C

    2007-12-01

    Full Text Available Abstract We report a case of fulminant multiple organ failure including the Acute Respiratory Distress Syndrome (ARDS, haemodynamic, and renal failure due to community-acquired methicillin-sensitive Panton Valentine Leukocidin (PVL positive spa-type 284 (ST121 Staphylococcus aureus septic shock. The patient's first clinical symptom was necrotizing pneumonia. Despite organism-sensitive triple antibiotic therapy with linezolid, imipenem and clindamycin from the first day of treatment, progressive abscess formation in multiple skeletal muscles was observed. As a result, repeated surgical interventions became necessary. Due to progressive soft tissue infection, the anti-microbial therapy was changed to a combination of clindamycin and daptomycin. Continued surgical and antimicrobial therapy finally led to a stabilisation of the patients' condition. The clinical course of our patient underlines the existence of a "PVL-syndrome" which is independent of in vitro Staphylococcus aureus susceptibility. The PVL-syndrome should not only be considered in patients with soft tissue or bone infection, but also in patients with pneumonia. Such a condition, which may easily be mistaken for uncomplicated pneumonia, should be treated early, aggressively and over a long period of time in order to avoid relapsing infection.

  8. Linear equations and rap battles: how students in a wired classroom utilized the computer as a resource to coordinate personal and mathematical positional identities in hybrid spaces

    Science.gov (United States)

    Langer-Osuna, Jennifer

    2015-03-01

    This paper draws on the constructs of hybridity, figured worlds, and cultural capital to examine how a group of African-American students in a technology-driven, project-based algebra classroom utilized the computer as a resource to coordinate personal and mathematical positional identities during group work. Analyses of several vignettes of small group dynamics highlight how hybridity was established as the students engaged in multiple on-task and off-task computer-based activities, each of which drew on different lived experiences and forms of cultural capital. The paper ends with a discussion on how classrooms that make use of student-led collaborative work, and where students are afforded autonomy, have the potential to support the academic engagement of students from historically marginalized communities.

  9. Linear Accelerators

    International Nuclear Information System (INIS)

    Vretenar, M

    2014-01-01

    The main features of radio-frequency linear accelerators are introduced, reviewing the different types of accelerating structures and presenting the main characteristics aspects of linac beam dynamics

  10. Linearization Method and Linear Complexity

    Science.gov (United States)

    Tanaka, Hidema

    We focus on the relationship between the linearization method and linear complexity and show that the linearization method is another effective technique for calculating linear complexity. We analyze its effectiveness by comparing with the logic circuit method. We compare the relevant conditions and necessary computational cost with those of the Berlekamp-Massey algorithm and the Games-Chan algorithm. The significant property of a linearization method is that it needs no output sequence from a pseudo-random number generator (PRNG) because it calculates linear complexity using the algebraic expression of its algorithm. When a PRNG has n [bit] stages (registers or internal states), the necessary computational cost is smaller than O(2n). On the other hand, the Berlekamp-Massey algorithm needs O(N2) where N(≅2n) denotes period. Since existing methods calculate using the output sequence, an initial value of PRNG influences a resultant value of linear complexity. Therefore, a linear complexity is generally given as an estimate value. On the other hand, a linearization method calculates from an algorithm of PRNG, it can determine the lower bound of linear complexity.

  11. Improving the precision of linear optics measurements based on turn-by-turn beam position monitor data after a pulsed excitation in lepton storage rings

    Directory of Open Access Journals (Sweden)

    L. Malina

    2017-08-01

    Full Text Available Beam optics control is of critical importance for machine performance and protection. Nowadays, turn-by-turn (TbT beam position monitor (BPM data are increasingly exploited as they allow for fast and simultaneous measurement of various optics quantities. Nevertheless, so far the best documented uncertainty of measured β-functions is of about 10‰ rms. In this paper we compare the β-functions of the ESRF storage ring measured from two different TbT techniques—the N-BPM and the Amplitude methods—with the ones inferred from a measurement of the orbit response matrix (ORM. We show how to improve the precision of TbT techniques by refining the Fourier transform of TbT data with properly chosen excitation amplitude. The precision of the N-BPM method is further improved by refining the phase advance measurement. This represents a step forward compared to standard TbT measurements. First experimental results showing the precision of β-functions pushed down to 4‰ both in TbT and ORM techniques are reported and commented.

  12. Linear algebra

    CERN Document Server

    Said-Houari, Belkacem

    2017-01-01

    This self-contained, clearly written textbook on linear algebra is easily accessible for students. It begins with the simple linear equation and generalizes several notions from this equation for the system of linear equations and introduces the main ideas using matrices. It then offers a detailed chapter on determinants and introduces the main ideas with detailed proofs. The third chapter introduces the Euclidean spaces using very simple geometric ideas and discusses various major inequalities and identities. These ideas offer a solid basis for understanding general Hilbert spaces in functional analysis. The following two chapters address general vector spaces, including some rigorous proofs to all the main results, and linear transformation: areas that are ignored or are poorly explained in many textbooks. Chapter 6 introduces the idea of matrices using linear transformation, which is easier to understand than the usual theory of matrices approach. The final two chapters are more advanced, introducing t...

  13. Sensitive monitoring of monoterpene metabolites in human urine using two-step derivatisation and positive chemical ionisation-tandem mass spectrometry

    International Nuclear Information System (INIS)

    Schmidt, Lukas; Belov, Vladimir N.; Göen, Thomas

    2013-01-01

    Highlights: •Sensitive monitoring of 10 metabolites of (R)-limonene, α-pinene, and Δ 3 -carene in human urine samples. •Fast and simple sample preparation and derivatisation procedure using two-step silylation for unreactive tertiary hydroxyl groups. •Synthesis of reference substances and isotopically labelled internal standards of (R)-limonene, α-pinene, and Δ 3 -carene metabolites. •Study on (R)-limonene, α-pinene, and Δ 3 -carene metabolite background exposure of 36 occupationally unexposed volunteers. -- Abstract: A gas chromatographic–positive chemical ionisation-tandem mass spectrometric (GC–PCI-MS/MS) method for the simultaneous determination of 10 oxidative metabolites of the monoterpenoid hydrocarbons α-pinene, (R)-limonene, and Δ 3 -carene ((+)-3-carene) in human urine was developed and tested for the monoterpene biomonitoring of the general population (n = 36). The method involves enzymatic cleavage of the glucuronides followed by solid-supported liquid–liquid extraction and derivatisation using a two-step reaction with N,O-bis(trimethylsilyl)-trifluoroacetamide and N-(trimethylsilyl)imidazole. The method proved to be both sensitive and reliable with detection limits ranging from 0.1 to 0.3 μg L −1 . In contrast to the frequent and distinct quantities of (1S,2S,4R)-limonene-1,2-diol, the (1R,2R,4R)-stereoisomer could not be detected. The expected metabolite of (+)-3-carene, 3-caren-10-ol was not detected in any of the samples. All other metabolites were detected in almost all urine samples. The procedure enables for the first time the analysis of trace levels of a broad spectrum of mono- and bicyclic monoterpenoid metabolites (alcohols, diols, and carboxylic acids) in human urine. This analytical procedure is a powerful tool for population studies as well as for the discovery of human metabolism and toxicokinetics of monoterpenes

  14. Mechanistic study on lowering the sensitivity of positive atmospheric pressure photoionization mass spectrometric analyses: size-dependent reactivity of solvent clusters.

    Science.gov (United States)

    Ahmed, Arif; Choi, Cheol Ho; Kim, Sunghwan

    2015-11-15

    Understanding the mechanism of atmospheric pressure photoionization (APPI) is important for studies employing APPI liquid chromatography/mass spectrometry (LC/MS). In this study, the APPI mechanism for polyaromatic hydrocarbon (PAH) compounds dissolved in toluene and methanol or water mixture was investigated by use of MS analysis and quantum mechanical simulation. In particular, four different mechanisms that could contribute to the signal reduction were considered based on a combination of MS data and quantum mechanical calculations. The APPI mechanism is clarified by combining MS data and density functional theory (DFT) calculations. To obtain MS data, a positive-mode (+) APPI Q Exactive Orbitrap mass spectrometer was used to analyze each solution. DFT calculations were performed using the general atomic and molecular electronic structure system (GAMESS). The experimental results indicated that methanol significantly reduced the signal in (+) APPI, but no significative signal reduction was observed when water was used as a co-solvent with toluene. The signal reduction is more significant especially for molecular ions than for protonated ions. Therefore, important information about the mechanism of methanol-induced signal reduction in (+) APPI-MS can be gained due its negative impact on APPI efficiency. The size-dependent reactivity of methanol clusters ((CH3 OH)n , n = 1-8) is an important factor in determining the sensitivity of (+) APPI-MS analyses. Clusters can compete with toluene radical ions for electrons. The reactivity increases as the sizes of the methanol clusters increase and this effect can be caused by the size-dependent ionization energy of the solvent clusters. The resulting increase in cluster reactivity explains the flow rate and temperature-dependent signal reduction observed in the analytes. Based on the results presented here, minimizing the sizes of methanol clusters can improve the sensitivity of LC/(+)-APPI-MS. Copyright © 2015 John

  15. Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets.

    Science.gov (United States)

    Huang, Jiung-Pang; Cheng, Mei-Ling; Hung, Cheng-Yu; Wang, Chao-Hung; Hsieh, Po-Shiuan; Shiao, Ming-Shi; Chen, Jan-Kan; Li, Dai-Er; Hung, Li-Man

    2017-10-01

    The aim of the present study was to compare insulin resistance and metabolic changes using a global lipidomic approach. Rats were fed a high-fat diet (HFD) or a high-fructose diet (HFrD) for 12 weeks to induce insulin resistance (IR) syndrome. After 12 weeks feeding, physiological and biochemical parameters were examined. Insulin sensitivity and plasma metabolites were evaluated using a euglycemic-hyperinsulinemic clamp and mass spectrometry, respectively. Pearson's correlation coefficient was used to investigate the strength of correlations. Rats on both diets developed IR syndrome, characterized by hypertension, hyperlipidemia, hyperinsulinemia, impaired fasting glucose, and IR. Compared with HFrD-fed rats, non-esterified fatty acids were lower and body weight and plasma insulin levels were markedly higher in HFD-fed rats. Adiposity and plasma leptin levels were increased in both groups. However, the size of adipocytes was greater in HFD- than HFrD-fed rats. Notably, the lipidomic heat map revealed metabolites exhibiting greater differences in HFD- and HFrD-fed rats compared with controls. Plasma adrenic acid levels were higher in HFD- than HFrD-fed rats. Nevertheless, linoleic and arachidonic acid levels decreased in HFrD-fed rats compared with controls. Plasma concentrations of docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) were significantly reduced after feeding of both diets, particularly the HFrD. There was a strong positive correlation between these two fatty acids and the insulin sensitivity index. The systemic lipidomic analysis indicated that a reduction in DHA and DPA was strongly correlated with IR in rats under long-term overnutrition. These results provide a potential therapeutic target for IR and metabolic syndrome. © 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

  16. Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression

    Energy Technology Data Exchange (ETDEWEB)

    Li, Luchuan; Lv, Bin; Chen, Bo [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Guan, Ming [Department of General Surgery, Qihe People' s Hospital, Qihe, Shandong 251100 (China); Sun, Yongfeng [Department of General Surgery, Licheng District People' s Hospital, Jinan, Shandong 250115 (China); Li, Haipeng [Department of General Surgery, Caoxian People' s Hospital, Caoxian, Shandong 274400 (China); Zhang, Binbin; Ding, Changyuan; He, Shan [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Zeng, Qingdong, E-mail: qingdz0201@163.com [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China)

    2015-07-10

    Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the role of miRNAs in RAIU has not been generally investigated. Based on recent studies about miRNA expression in papillary or follicular thyroid carcinomas, the expression profiles of several thyroid relative miRNAs were investigated in one DTC cell line, derived from normal DTC cells by radioiodine treatment. The top candidate miR-146b, with the most significant overexpression profiles in dedifferentiated cells, was picked up. Further research found that miR-146b could be negatively regulated by histone deacetylase 3 (HDAC3) in normal cells, indicating the correlation between miR-146b and Na{sup +}/I{sup −} symporter (NIS)-mediated RAIU. Fortunately, it was confirmed that miR-146b could regulate NIS expression/activity; what is more important, miR-146b interference would contribute to the recovery of radioiodine-sensitivity in dedifferentiated cells via positively regulating NIS. In the present study, it was concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma (PDTC). - Highlights: • Significant upregulated miR-146b was picked up from thyroid relative miRNAs in DTC. • MiR-146b was negatively regulated by HDAC3 in normal thyroid carcinoma cells. • NIS activity and expression could be regulated by miR-146b in thyroid carcinoma. • MiR-146b inhibition could recover the decreased radioiodine-sensitivity of DTC cells.

  17. A combination of positive dielectrophoresis driven on-line enrichment and aptamer-fluorescent silica nanoparticle label for rapid and sensitive detection of Staphylococcus aureus.

    Science.gov (United States)

    Shangguan, Jingfang; Li, Yuhong; He, Dinggeng; He, Xiaoxiao; Wang, Kemin; Zou, Zhen; Shi, Hui

    2015-07-07

    Staphylococcus aureus (S. aureus) is an important human pathogen that causes several diseases ranging from superficial skin infections to life-threatening diseases. Here, a method combining positive dielectrophoresis (pDEP) driven on-line enrichment and aptamer-fluorescent silica nanoparticle label has been developed for the rapid and sensitive detection of S. aureus in microfluidic channels. An aptamer, having high affinity to S. aureus, is used as the molecular recognition tool and immobilized onto chloropropyl functionalized fluorescent silica nanoparticles through a click chemistry approach to obtain S. aureus aptamer-nanoparticle bioconjugates (Apt(S.aureus)/FNPs). The pDEP driven on-line enrichment technology was used for accumulating the Apt(S.aureus)/FNP labeled S. aureus. After incubating with S. aureus, the mixture of Apt(S.aureus)/FNP labeled S. aureus and Apt(S.aureus)/FNPs was directly introduced into the pDEP-based microfluidic system. By applying an AC voltage in a pDEP frequency region, the Apt(S.aureus)/FNP labelled S. aureus moved to the electrodes and accumulated in the electrode gap, while the free Apt(S.aureus)/FNPs flowed away. The signal that came from the Apt(S.aureus)/FNP labelled S. aureus in the focused detection areas was then detected. Profiting from the specificity of aptamer, signal amplification of FNP label and pDEP on-line enrichment, this assay can detect as low as 93 and 270 cfu mL(-1)S. aureus in deionized water and spiked water samples, respectively, with higher sensitivities than our previously reported Apt(S.aureus)/FNP based flow cytometry. Moreover, without the need for separation and washing steps usually required for FNP label involved bioassays, the total assay time including sample pretreatment was within 2 h.

  18. Linear algebra

    CERN Document Server

    Stoll, R R

    1968-01-01

    Linear Algebra is intended to be used as a text for a one-semester course in linear algebra at the undergraduate level. The treatment of the subject will be both useful to students of mathematics and those interested primarily in applications of the theory. The major prerequisite for mastering the material is the readiness of the student to reason abstractly. Specifically, this calls for an understanding of the fact that axioms are assumptions and that theorems are logical consequences of one or more axioms. Familiarity with calculus and linear differential equations is required for understand

  19. Linear programming

    CERN Document Server

    Solow, Daniel

    2014-01-01

    This text covers the basic theory and computation for a first course in linear programming, including substantial material on mathematical proof techniques and sophisticated computation methods. Includes Appendix on using Excel. 1984 edition.

  20. Linear algebra

    CERN Document Server

    Liesen, Jörg

    2015-01-01

    This self-contained textbook takes a matrix-oriented approach to linear algebra and presents a complete theory, including all details and proofs, culminating in the Jordan canonical form and its proof. Throughout the development, the applicability of the results is highlighted. Additionally, the book presents special topics from applied linear algebra including matrix functions, the singular value decomposition, the Kronecker product and linear matrix equations. The matrix-oriented approach to linear algebra leads to a better intuition and a deeper understanding of the abstract concepts, and therefore simplifies their use in real world applications. Some of these applications are presented in detailed examples. In several ‘MATLAB-Minutes’ students can comprehend the concepts and results using computational experiments. Necessary basics for the use of MATLAB are presented in a short introduction. Students can also actively work with the material and practice their mathematical skills in more than 300 exerc...

  1. Linear algebra

    CERN Document Server

    Berberian, Sterling K

    2014-01-01

    Introductory treatment covers basic theory of vector spaces and linear maps - dimension, determinants, eigenvalues, and eigenvectors - plus more advanced topics such as the study of canonical forms for matrices. 1992 edition.

  2. Linear Models

    CERN Document Server

    Searle, Shayle R

    2012-01-01

    This 1971 classic on linear models is once again available--as a Wiley Classics Library Edition. It features material that can be understood by any statistician who understands matrix algebra and basic statistical methods.

  3. LINEAR ACCELERATOR

    Science.gov (United States)

    Christofilos, N.C.; Polk, I.J.

    1959-02-17

    Improvements in linear particle accelerators are described. A drift tube system for a linear ion accelerator reduces gap capacity between adjacent drift tube ends. This is accomplished by reducing the ratio of the diameter of the drift tube to the diameter of the resonant cavity. Concentration of magnetic field intensity at the longitudinal midpoint of the external sunface of each drift tube is reduced by increasing the external drift tube diameter at the longitudinal center region.

  4. Efficacy of the Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline in Twin Families (VIPP-Twins): Study protocol for a randomized controlled trial.

    Science.gov (United States)

    Euser, Saskia; Bakermans-Kranenburg, Marian J; van den Bulk, Bianca G; Linting, Mariëlle; Damsteegt, Rani C; Vrijhof, Claudia I; van Wijk, Ilse C; Crone, Eveline A; van IJzendoorn, Marinus H

    2016-06-06

    Intervention programs with the aim of enhancing parenting quality have been found to be differentially effective in decreasing negative child outcomes such as externalizing behavioral problems, resulting in modest overall effect sizes. Here we present the protocol for a randomized controlled trial to examine the efficacy of the Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline for Twin Families (VIPP-Twins) on parenting quality and children's behavioral control and social competence. In addition, we aim to test the differential susceptibility theory; we examine differential efficacy of the intervention based on genetic make-up or temperament for both parents and children. Lastly, we explore neurobiological mechanisms underlying intervention effects on children's developmental outcomes. The original VIPP-SD was adapted for use in families with twins. The VIPP-Twins consists of five biweekly sessions in which the families are visited at home, parent-child interactions are videotaped and parents receive positive feedback on selected video fragments. Families (N = 225) with a same sex twin (mean age = 3.6 years) were recruited to participate in the study. The study consists of four assessments. After two baseline assessments in year 1 and year 2, a random 40 % of the sample will receive the VIPP-Twins program. The first post-test assessment will be carried out one month after the intervention and there will be a long term follow-up assessment two years after the intervention. Measures include observational assessments of parenting and children's social competence and behavioral control, and neurobiological assessments (i.e., hormonal functioning and neural (re-)activity). Results of the study will provide insights in the efficacy of the VIPP-Twins and reveal moderators and mediators of program efficacy. Overall the randomized controlled trial is an experimental test of the differential susceptibility theory. Dutch Trial

  5. Multi-class geospatial object detection based on a position-sensitive balancing framework for high spatial resolution remote sensing imagery

    Science.gov (United States)

    Zhong, Yanfei; Han, Xiaobing; Zhang, Liangpei

    2018-04-01

    Multi-class geospatial object detection from high spatial resolution (HSR) remote sensing imagery is attracting increasing attention in a wide range of object-related civil and engineering applications. However, the distribution of objects in HSR remote sensing imagery is location-variable and complicated, and how to accurately detect the objects in HSR remote sensing imagery is a critical problem. Due to the powerful feature extraction and representation capability of deep learning, the deep learning based region proposal generation and object detection integrated framework has greatly promoted the performance of multi-class geospatial object detection for HSR remote sensing imagery. However, due to the translation caused by the convolution operation in the convolutional neural network (CNN), although the performance of the classification stage is seldom influenced, the localization accuracies of the predicted bounding boxes in the detection stage are easily influenced. The dilemma between translation-invariance in the classification stage and translation-variance in the object detection stage has not been addressed for HSR remote sensing imagery, and causes position accuracy problems for multi-class geospatial object detection with region proposal generation and object detection. In order to further improve the performance of the region proposal generation and object detection integrated framework for HSR remote sensing imagery object detection, a position-sensitive balancing (PSB) framework is proposed in this paper for multi-class geospatial object detection from HSR remote sensing imagery. The proposed PSB framework takes full advantage of the fully convolutional network (FCN), on the basis of a residual network, and adopts the PSB framework to solve the dilemma between translation-invariance in the classification stage and translation-variance in the object detection stage. In addition, a pre-training mechanism is utilized to accelerate the training procedure

  6. High-Energy 3D Calorimeter based on position-sensitive virtual Frisch-grid CdZnTe detectors for use in Gamma-ray Astronomy

    Energy Technology Data Exchange (ETDEWEB)

    Bolotnikov, Alexey [Brookhaven National Lab. (BNL), Upton, NY (United States); De Geronimo, GianLuigi [Brookhaven National Lab. (BNL), Upton, NY (United States); Vernon, Emerson [Brookhaven National Lab. (BNL), Upton, NY (United States); Hays, Elizabeth [NASA Goddard Space Flight Center (GSFC), Greenbelt, MD (United States); Thompson, David [NASA Goddard Space Flight Center (GSFC), Greenbelt, MD (United States); James, Ralph [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Moiseev, Alexander [Center for Research and Exploration; Technology, NASA Goddard Space Flight Center (GSFC) and Univ. of Maryland, Greenbelt, MD (United States)

    2017-08-12

    We present a concept for a calorimeter based on a novel approach of 3D position-sensitive virtual Frischgrid CZT detectors. This calorimeter aims to measure photons with energies from ~100 keV to 10 (goal 50) MeV. The expected energy resolution at 662 keV is ~1% FWHM, and the photon interaction positionmeasurement accuracy is ~1 mm in all 3 dimensions. Each CZT bar is a rectangular prism with typical cross-section of 6x6 mm2 and length of 2-4 cm. The bars are arranged in modules of 4 x 4 bars, and the modules themselves can be assembled into a larger array. The 3D virtual voxel approach solves a long-standing problem with CZT detectors associated with material imperfections that limit the performance and usefulness of relatively thick detectors (i.e., > 1 cm). Also, it allows us to relax the requirements on the quality of the crystals, maintaining good energy resolution and significantly reducing the instrument cost. Such a calorimeter can be successfully used in space telescopes that use Compton scattering of γ rays, such as AMEGO, serving as part of its calorimeter and providing the position and energy measurement for Compton-scattered photons. Also, it could provide suitable energy resolution to allow for spectroscopic measurements of γ-ray lines from nuclear decays. Another viable option is to use this calorimeter as a focal plane to conduct spectroscopic measurements of cosmic γ-ray events. In combination with a coded-aperture mask, it potentially could provide mapping of the 511-keV radiation from the Galactic Center region.

  7. In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate

    Science.gov (United States)

    Groman, Stephanie M.; James, Alex S.; Seu, Emanuele; Tran, Steven; Clark, Taylor A.; Harpster, Sandra N.; Crawford, Maverick; Burtner, Joanna Lee; Feiler, Karen; Roth, Robert H.; Elsworth, John D.; London, Edythe D.

    2014-01-01

    For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human brain; this technique has revealed important relationships between dopamine D2-like receptors and dimensions of normal behavior, such as human impulsivity, and psychopathology, particularly behavioral addictions. Nevertheless, PET is an indirect estimate that lacks cellular and functional resolution and, in some cases, is not entirely pharmacologically specific. To identify the relationships between PET estimates of D2-like receptor availability and direct in vitro measures of receptor number, affinity, and function, we conducted neuroimaging and behavioral and molecular pharmacological assessments in a group of adult male vervet monkeys. Data gathered from these studies indicate that variation in D2-like receptor PET measurements is related to reversal-learning performance and sensitivity to positive feedback and is associated with in vitro estimates of the density of functional dopamine D2-like receptors. Furthermore, we report that a simple behavioral measure, eyeblink rate, reveals novel and crucial links between neuroimaging assessments and in vitro measures of dopamine D2 receptors. PMID:25339755

  8. Improved sensitivity of ochratoxin A analysis in coffee using high-performance liquid chromatography with hybrid triple quadrupole-linear ion trap mass spectrometry (LC-QqQLIT-MS/MS).

    Science.gov (United States)

    Kokina, Aija; Pugajeva, Iveta; Bartkevics, Vadims

    2016-01-01

    A novel and sensitive method utilising high-performance liquid chromatography coupled to triple quadrupole-linear ion trap mass spectrometry (LC-QqQLIT-MS/MS) was developed in order to analyse the content of ochratoxin A (OTA) in coffee samples. The introduction of the triple-stage MS scanning mode (MS(3)) has been shown to increase greatly sensitivity and selectivity by eliminating the high chromatographic baseline caused by interference of complex coffee matrices. The analysis included the sample preparation procedure involving extraction of OTA using a methanol-water mixture and clean-up by immunoaffinity columns and detection using the MS(3) scanning mode of LC-QqQLIT-MS/MS. The proposed method offered a good linear correlation (r(2) > 0.998), excellent precision (RSD coffee beans and espresso beverages was 0.010 and 0.003 µg kg(-1), respectively. The developed procedure was compared with traditional methods employing liquid chromatography coupled to fluorescent and tandem quadrupole detectors in conjunction with QuEChERS and solid-phase extraction. The proposed method was successfully applied to the determination of OTA in 15 samples of coffee beans and in 15 samples of espresso coffee beverages obtained from the Latvian market. OTA was found in 10 samples of coffee beans and in two samples of espresso in the ranges of 0.018-1.80 µg kg(-1) and 0.020-0.440 µg l(-1), respectively. No samples exceeded the maximum permitted level of OTA in the European Union (5.0 µg kg(-1)).

  9. Sensitive monitoring of monoterpene metabolites in human urine using two-step derivatisation and positive chemical ionisation-tandem mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Lukas [Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054 Erlangen (Germany); Belov, Vladimir N. [Max Planck Institute for Biophysical Chemistry, Facility for Synthetic Chemistry, Am Fassberg 11, 37077 Göttingen (Germany); Göen, Thomas, E-mail: Thomas.Goeen@ipasum.med.uni-erlangen.de [Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054 Erlangen (Germany)

    2013-09-02

    Highlights: •Sensitive monitoring of 10 metabolites of (R)-limonene, α-pinene, and Δ{sup 3}-carene in human urine samples. •Fast and simple sample preparation and derivatisation procedure using two-step silylation for unreactive tertiary hydroxyl groups. •Synthesis of reference substances and isotopically labelled internal standards of (R)-limonene, α-pinene, and Δ{sup 3}-carene metabolites. •Study on (R)-limonene, α-pinene, and Δ{sup 3}-carene metabolite background exposure of 36 occupationally unexposed volunteers. -- Abstract: A gas chromatographic–positive chemical ionisation-tandem mass spectrometric (GC–PCI-MS/MS) method for the simultaneous determination of 10 oxidative metabolites of the monoterpenoid hydrocarbons α-pinene, (R)-limonene, and Δ{sup 3}-carene ((+)-3-carene) in human urine was developed and tested for the monoterpene biomonitoring of the general population (n = 36). The method involves enzymatic cleavage of the glucuronides followed by solid-supported liquid–liquid extraction and derivatisation using a two-step reaction with N,O-bis(trimethylsilyl)-trifluoroacetamide and N-(trimethylsilyl)imidazole. The method proved to be both sensitive and reliable with detection limits ranging from 0.1 to 0.3 μg L{sup −1}. In contrast to the frequent and distinct quantities of (1S,2S,4R)-limonene-1,2-diol, the (1R,2R,4R)-stereoisomer could not be detected. The expected metabolite of (+)-3-carene, 3-caren-10-ol was not detected in any of the samples. All other metabolites were detected in almost all urine samples. The procedure enables for the first time the analysis of trace levels of a broad spectrum of mono- and bicyclic monoterpenoid metabolites (alcohols, diols, and carboxylic acids) in human urine. This analytical procedure is a powerful tool for population studies as well as for the discovery of human metabolism and toxicokinetics of monoterpenes.

  10. Linear regression

    CERN Document Server

    Olive, David J

    2017-01-01

    This text covers both multiple linear regression and some experimental design models. The text uses the response plot to visualize the model and to detect outliers, does not assume that the error distribution has a known parametric distribution, develops prediction intervals that work when the error distribution is unknown, suggests bootstrap hypothesis tests that may be useful for inference after variable selection, and develops prediction regions and large sample theory for the multivariate linear regression model that has m response variables. A relationship between multivariate prediction regions and confidence regions provides a simple way to bootstrap confidence regions. These confidence regions often provide a practical method for testing hypotheses. There is also a chapter on generalized linear models and generalized additive models. There are many R functions to produce response and residual plots, to simulate prediction intervals and hypothesis tests, to detect outliers, and to choose response trans...

  11. Linear Colliders

    International Nuclear Information System (INIS)

    Alcaraz, J.

    2001-01-01

    After several years of study e''+ e''- linear colliders in the TeV range have emerged as the major and optimal high-energy physics projects for the post-LHC era. These notes summarize the present status form the main accelerator and detector features to their physics potential. The LHC era. These notes summarize the present status, from the main accelerator and detector features to their physics potential. The LHC is expected to provide first discoveries in the new energy domain, whereas an e''+ e''- linear collider in the 500 GeV-1 TeV will be able to complement it to an unprecedented level of precision in any possible areas: Higgs, signals beyond the SM and electroweak measurements. It is evident that the Linear Collider program will constitute a major step in the understanding of the nature of the new physics beyond the Standard Model. (Author) 22 refs

  12. Linear algebra

    CERN Document Server

    Edwards, Harold M

    1995-01-01

    In his new undergraduate textbook, Harold M Edwards proposes a radically new and thoroughly algorithmic approach to linear algebra Originally inspired by the constructive philosophy of mathematics championed in the 19th century by Leopold Kronecker, the approach is well suited to students in the computer-dominated late 20th century Each proof is an algorithm described in English that can be translated into the computer language the class is using and put to work solving problems and generating new examples, making the study of linear algebra a truly interactive experience Designed for a one-semester course, this text adopts an algorithmic approach to linear algebra giving the student many examples to work through and copious exercises to test their skills and extend their knowledge of the subject Students at all levels will find much interactive instruction in this text while teachers will find stimulating examples and methods of approach to the subject

  13. Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea.

    Directory of Open Access Journals (Sweden)

    Valeria Zampini

    Full Text Available Hearing relies on faithful signal transmission by cochlear inner hair cells (IHCs onto auditory fibres over a wide frequency and intensity range. Exocytosis at IHC ribbon synapses is triggered by Ca(2+ inflow through Ca(V1.3 (L-type Ca(2+ channels. We investigated the macroscopic (whole-cell and elementary (cell-attached properties of Ca(2+ currents in IHCs positioned at the middle turn (frequency ∼ 2 kHz of the adult gerbil cochlea, which is their most sensitive hearing region. Using near physiological recordings conditions (body temperature and a Na(+ based extracellular solution, we found that the macroscopic Ca(2+ current activates and deactivates very rapidly (time constant below 1 ms and inactivates slowly and only partially. Single-channel recordings showed an elementary conductance of 15 pS, a sub-ms latency to first opening, and a very low steady-state open probability (Po: 0.024 in response to 500-ms depolarizing steps at ∼-18 mV. The value of Po was significantly larger (0.06 in the first 40 ms of membrane depolarization, which corresponds to the time when most Ca(2+ channel openings occurred clustered in bursts (mean burst duration: 19 ms. Both the Po and the mean burst duration were smaller than those previously reported in high-frequency basal IHCs. Finally, we found that middle turn IHCs are likely to express about 4 times more Ca(2+ channels per ribbon than basal cells. We propose that middle-turn IHCs finely-tune Ca(V1.3 Ca(2+ channel gating in order to provide reliable information upon timing and intensity of lower-frequency sounds.

  14. Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea.

    Science.gov (United States)

    Zampini, Valeria; Johnson, Stuart L; Franz, Christoph; Knipper, Marlies; Holley, Matthew C; Magistretti, Jacopo; Russo, Giancarlo; Marcotti, Walter; Masetto, Sergio

    2014-01-01

    Hearing relies on faithful signal transmission by cochlear inner hair cells (IHCs) onto auditory fibres over a wide frequency and intensity range. Exocytosis at IHC ribbon synapses is triggered by Ca(2+) inflow through Ca(V)1.3 (L-type) Ca(2+) channels. We investigated the macroscopic (whole-cell) and elementary (cell-attached) properties of Ca(2+) currents in IHCs positioned at the middle turn (frequency ∼ 2 kHz) of the adult gerbil cochlea, which is their most sensitive hearing region. Using near physiological recordings conditions (body temperature and a Na(+) based extracellular solution), we found that the macroscopic Ca(2+) current activates and deactivates very rapidly (time constant below 1 ms) and inactivates slowly and only partially. Single-channel recordings showed an elementary conductance of 15 pS, a sub-ms latency to first opening, and a very low steady-state open probability (Po: 0.024 in response to 500-ms depolarizing steps at ∼-18 mV). The value of Po was significantly larger (0.06) in the first 40 ms of membrane depolarization, which corresponds to the time when most Ca(2+) channel openings occurred clustered in bursts (mean burst duration: 19 ms). Both the Po and the mean burst duration were smaller than those previously reported in high-frequency basal IHCs. Finally, we found that middle turn IHCs are likely to express about 4 times more Ca(2+) channels per ribbon than basal cells. We propose that middle-turn IHCs finely-tune Ca(V)1.3 Ca(2+) channel gating in order to provide reliable information upon timing and intensity of lower-frequency sounds.

  15. Reduced sensitivity of the N400 and late positive component to semantic congruity and word repetition in left temporal lobe epilepsy.

    Science.gov (United States)

    Olichney, John M; Riggins, Brock R; Hillert, Dieter G; Nowacki, Ralph; Tecoma, Evelyn; Kutas, Marta; Iragui, Vicente J

    2002-07-01

    We studied 14 patients with well-characterized refractory temporal lobe epilepsy (TLE), 7 with right temporal lobe epilepsy (RTE) and 7 with left temporal lobe epilepsy (LTE), on a word repetition ERP experiment. Much prior literature supports the view that patients with left TLE are more likely to develop verbal memory deficits, often attributable to left hippocampal sclerosis. Our main objectives were to test if abnormalities of the N400 or Late Positive Component (LPC, P600) were associated with a left temporal seizure focus, or left temporal lobe dysfunction. A minimum of 19 channels of EEG/EOG data were collected while subjects performed a semantic categorization task. Auditory category statements were followed by a visual target word, which were 50% "congruous" (category exemplars) and 50% "incongruous" (non-category exemplars) with the preceding semantic context. These auditory-visual pairings were repeated pseudo-randomly at time intervals ranging from approximately 10-140 seconds later. The ERP data were submitted to repeated-measures ANOVAs, which showed the RTE group had generally normal effects of word repetition on the LPC and the N400. Also, the N400 component was larger to incongruous than congruous new words, as is normally the case. In contrast, the LTE group did not have statistically significant effects of either word repetition or congruity on their ERPs (N400 or LPC), suggesting that this ERP semantic categorization paradigm is sensitive to left temporal lobe dysfunction. Further studies are ongoing to determine if these ERP abnormalities predict hippocampal sclerosis on histopathology, or outcome after anterior temporal lobectomy.

  16. Position encoder

    International Nuclear Information System (INIS)

    Goursky, Vsevolod

    1975-01-01

    A circuitry for deriving the quotient of signal delivered by position-sensitive detectors is described. Digital output is obtained in the form of 10- to 12-bit words. Impact position may be determined with 0.25% accuracy when the dynamic range of the energy signal is less 1:10, and 0.5% accuracy when the dynamic range is 1:20. The division requires an average time of 5μs for 10-bit words

  17. Position encoder

    International Nuclear Information System (INIS)

    Goursky, V.

    1975-05-01

    This paper describes circuitry for deriving the quotient of signals delivered by position-sensitive detectors. Digital output is obtained in the form of 10 to 12 bit words. Impact position may be determined with 0.25% accuracy when the dynamic range of the energy signal is less than 1:10, and 0.5% accuracy when the dynamic range is 1:20. The division requires an average time of 5μs for 10-bit words [fr

  18. Linear programming

    CERN Document Server

    Karloff, Howard

    1991-01-01

    To this reviewer’s knowledge, this is the first book accessible to the upper division undergraduate or beginning graduate student that surveys linear programming from the Simplex Method…via the Ellipsoid algorithm to Karmarkar’s algorithm. Moreover, its point of view is algorithmic and thus it provides both a history and a case history of work in complexity theory. The presentation is admirable; Karloff's style is informal (even humorous at times) without sacrificing anything necessary for understanding. Diagrams (including horizontal brackets that group terms) aid in providing clarity. The end-of-chapter notes are helpful...Recommended highly for acquisition, since it is not only a textbook, but can also be used for independent reading and study. —Choice Reviews The reader will be well served by reading the monograph from cover to cover. The author succeeds in providing a concise, readable, understandable introduction to modern linear programming. —Mathematics of Computing This is a textbook intend...

  19. Linear mass reflectron

    International Nuclear Information System (INIS)

    Mamyrin, B.A.; Shmikk, D.V.

    1979-01-01

    A description and operating principle of a linear mass reflectron with V-form trajectory of ion motion -a new non-magnetic time-of-flight mass spectrometer with high resolution are presented. The ion-optical system of the device consists of an ion source with ionization by electron shock, of accelerating gaps, reflector gaps, a drift space and ion detector. Ions move in the linear mass refraction along the trajectories parallel to the axis of the analyzer chamber. The results of investigations into the experimental device are given. With an ion drift length of 0.6 m the device resolution is 1200 with respect to the peak width at half-height. Small-sized mass spectrometric transducers with high resolution and sensitivity may be designed on the base of the linear mass reflectron principle

  20. Development of LLNA:DAE: a new local lymph node assay that includes the elicitation phase, discriminates borderline-positive chemicals, and is useful for cross-sensitization testing.

    Science.gov (United States)

    Yamashita, Kunihiko; Shinoda, Shinsuke; Hagiwara, Saori; Itagaki, Hiroshi

    2014-02-01

    We developed a new local lymph node assay (LLNA) that includes the elicitation phase termed LLNA:DAE for discrimination of borderline-positive chemicals as classified by the LLNA modified by Daicel based on ATP content (LLNA:DA) and for cross-sensitization testing. Although the LLNA:DA method could help identify skin sensitizers, some skin irritants classified as non-sensitizers by the LLNA were classified as borderline positive. In addition, the evaluation for the cross-sensitization potential between chemicals was impossible. In the LLNA:DAE procedure, test group of mice received four applications of chemicals on the dorsum of the right ear for induction and one application on the dorsum of the left ear for elicitation. Control group of mice received one chemical application on the dorsum of the left ear. We evaluated the sensitizing potential by comparing the weights of the lymph nodes from the left ears between the two groups. The results of using the LLNA:DAE method to examine 24 chemicals, which contained borderline-positive chemicals, were consistent with those from the LLNA method, except for nickel chloride (NiCl2). Two chemical pairs, 2,4-dinitrochlorobenzene (DNCB) with 2,4-dinitrofluorobenzene (DNFB) and hydroquinone (HQ) with p-benzoquinone (p-BQ), showed clear cross-sensitization with each other, while another chemical pair, DNFB with hexylcinnamic aldehyde (HCA) did not. Taken together, our results suggest that the LLNA:DAE method is useful for discriminating borderline-positive chemicals and for determining chemical cross-sensitization.